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Sample records for bipolar led drive

  1. Advanced insulated gate bipolar transistor gate drive

    Science.gov (United States)

    Short, James Evans; West, Shawn Michael; Fabean, Robert J.

    2009-08-04

    A gate drive for an insulated gate bipolar transistor (IGBT) includes a control and protection module coupled to a collector terminal of the IGBT, an optical communications module coupled to the control and protection module, a power supply module coupled to the control and protection module and an output power stage module with inputs coupled to the power supply module and the control and protection module, and outputs coupled to a gate terminal and an emitter terminal of the IGBT. The optical communications module is configured to send control signals to the control and protection module. The power supply module is configured to distribute inputted power to the control and protection module. The control and protection module outputs on/off, soft turn-off and/or soft turn-on signals to the output power stage module, which, in turn, supplies a current based on the signal(s) from the control and protection module for charging or discharging an input capacitance of the IGBT.

  2. Two phase interleaved buck converter for driving high power LEDs

    OpenAIRE

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2011-01-01

    The goal of this paper is to evaluate an interleaved buck topology for driving high current light-emitting diodes. Low output capacitor value allows the use of non-electrolytic capacitors extending the lifetime of the converter. Converter is operated as a constant, regulated current source which increases luminous efficacy of LED compared to PWM dimmed system. Because of the low dynamic resistance of LEDs the duty cycle of the converter does not change greatly with controlled current. By sett...

  3. Design and implementation of a high dimming ratio LED drive controller

    Institute of Scientific and Technical Information of China (English)

    徐孝如; 吴晓波; 赵梦恋; 严晓浪

    2009-01-01

    This paper presents a high dimming ratio light emitting diode (LED) drive controller chip with digital mode dimming (DMD). The chip is composed of a boost power converter and a dimming control block. A novel constant on time (COT) control strategy is proposed for boost converter to achieve high dimming ratio. In addition, a fast enough load transient response of the converter power stage ensures its high dimming ratio. The COT control circuit operates mainly based on two current-capacitor timers and a finite state machine (FSM). The LED drive con-troller chip is designed and fabricated in 1.5μm bipolar CMOS-DMOS (BCD) process with a die area of 1.31 × 1.43 mm2. Experimental results show that the proposed LED drive system works well. And, as expected, the minimum LED dimming on time of 1.0μs and the corresponding dimming ratio of 1000 : 1 at 1 kHz dimming frequency are successfully achieved.

  4. Two phase interleaved buck converter for driving high power LEDs

    DEFF Research Database (Denmark)

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2011-01-01

    The goal of this paper is to evaluate an interleaved buck topology for driving high current light-emitting diodes. Low output capacitor value allows the use of non-electrolytic capacitors extending the lifetime of the converter. Converter is operated as a constant, regulated current source which...... increases luminous efficacy of LED compared to PWM dimmed system. Because of the low dynamic resistance of LEDs the duty cycle of the converter does not change greatly with controlled current. By setting the input voltage of the buck converter to around twice the voltage of diode strings, converter can be...

  5. Control and Driving Methods for LED Based Intelligent Light Sources

    DEFF Research Database (Denmark)

    Beczkowski, Szymon

    High power light-emitting diodes allow the creation of luminaires capable of generating saturated colour light at very high efficacies. Contrary to traditional light sources like incandescent and high-intensity discharge lamps, where colour is generated using filters, LEDs use additive light mixing......, where the intensity of each primary colour diode has to be adjusted to the needed intensity to generate specified colour. The function of LED driver is to supply the diode with power needed to achieve the desired intensity. Typically, the drivers operate as a current source and the intensity of the...... diode is controlled either by varying the magnitude of the current or by driving the LED with a pulsed current and regulate the width of the pulse. It has been shown previously, that these two methods yield different effects on diode's efficacy and colour point. A hybrid dimming strategy has been...

  6. High Efficiency Driving Electronics for General Illumination LED Luminaires

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyay, Anand

    2012-10-31

    New generation of standalone LED driver platforms developed, which are more efficient These LED Drivers are more efficient (≥90%), smaller in size ( 0.15 in3/watt), lower in cost ( 12 cents/watt in high volumes in millions of units). And these products are very reliable having an operating life of over 50,000 hours. This technology will enable growth of LED light sources in the use. This will also help in energy saving and reducing total life cycle cost of LED units. Two topologies selected for next generation of LED drivers: 1) Value engineered single stage Flyback topology. This is suitable for low powered LED drivers up to 50W power. 2) Two stage boost power factor correction (PFC) plus LLC half bridge platform for higher powers. This topology is suitable for 40W to 300W LED drivers. Three new product platforms were developed to cover a wide range of LED drivers: 1) 120V 40W LED driver, 2) Intellivolt 75W LED driver, & 3) Intellivolt 150W LED driver. These are standalone LED drivers for rugged outdoor lighting applications. Based on these platforms number of products are developed and successfully introduced in the market place meeting key performance, size and cost goals.

  7. LED Lighting & Its Driving%LED照明与驱动

    Institute of Scientific and Technical Information of China (English)

    路秋生

    2012-01-01

    This paper mainly introduce LED' s technical properties and its recently lumen deprecation and calculation, LED in using what need to pay attention to, LED driver's properties, the technical requirements for LED driver etc problems. and analysis on the interferences on LED driver. progress, LED in using its the facts which influence Also give an introduction%介绍了LED的主要技术特点和最新技术进展,LED在使用中的光衰和计算,LED驱动中需注意的有关问题,影响LED驱动电路性能的有关因素,LED对驱动电路的有关技术要求等问题。并对LED驱动电路在使用中遇到的各种干扰与特点进行了介绍和分析。

  8. Development of constant-power driving control for light-emitting-diode (LED) luminaire

    KAUST Repository

    Huang, Bin-Juine

    2013-01-01

    The illumination of an LED may be affected by operating temperature even under constant-current condition. A constant-power driving technique is proposed in the present study for LED luminaire. A linear system dynamics model of LED luminaire is first derived and used in the design of the feedback control system. The PI controller was designed and tuned taking into account the control accuracy and robust properties with respect to plant uncertainty and variation of operating conditions. The control system was implemented on a microprocessor and used to control a 150W LED luminaire. The test result shows that the feedback system accurately controls the input power of LED luminaire to within 1.3 per cent error. As the ambient temperature changes from 0 to 40 °C, the LED illumination varies slightly (-1.7%) for constant-power driving, as compared to that of constant-current driving (-12%) and constant-voltage driving (+50%). The constant-power driving has revealed advantage in stabilizing the illumination of LED under large temperature variation. © 2012 Elsevier Ltd. All rights reserved.

  9. Forward Conduction Mode Controlled Piezoelectric Transformer-Based PFC LED Drive

    DEFF Research Database (Denmark)

    Roedgaard, M. S.; Weirich, M.; Andersen, M. A. E.

    2013-01-01

    priced market. In this paper, a new forward conduction mode (FCM) control method for piezoelectric transformer (PT)-based power converters is proposed. A PT-based LED drive facilitating passive PFC is developed, utilizing and validating the FCM control method. The drive utilizes an inductorless half...

  10. SIMULATION ANALYSIS ON PROPORTIONAL INTEGRAL AND DERIVATIVE CONTROL OF CLOSED LOOP DC MOTOR DRIVE WITH BIPOLAR VOLTAGE SWITCHING

    OpenAIRE

    Karpagavalli, P.; A. Ebenezer Jeyakumar

    2013-01-01

    This study presents the performance of a new four quadrant single phase DC drive closed loop system controlled by proportional integral and derivative controller with Pulse Width Modulation (PWM) full bridge DC-DC converter using bipolar voltage switching. The proposed method is found to be more efficient in improving the step response characteristics such as reducing the settling time, rise time, steady state error and maximum overshoot in speed response of the closed loop DC motor drive and...

  11. Self-Excited Single-Stage Power Factor Correction Driving Circuit for LED Lighting

    OpenAIRE

    Yong-Nong Chang

    2014-01-01

    This pa per proposes a self-excited single-stage high power factor LED lighting driving circuit. Being featured with power factor correction capability without needing any control devices, the proposed circuit structure is with low cost and suitable for commercial production. The power factor correction function is accomplished by using inductor in combination with a half-bridge quasi resonant converter to achieve active switching and yield out voltage regulation according to load requirement...

  12. Self-Excited Single-Stage Power Factor Correction Driving Circuit for LED Lighting

    Directory of Open Access Journals (Sweden)

    Yong-Nong Chang

    2014-01-01

    Full Text Available This pa\tper proposes a self-excited single-stage high power factor LED lighting driving circuit. Being featured with power factor correction capability without needing any control devices, the proposed circuit structure is with low cost and suitable for commercial production. The power factor correction function is accomplished by using inductor in combination with a half-bridge quasi resonant converter to achieve active switching and yield out voltage regulation according to load requirement. Furthermore, the zero-voltage switching in the half-bridge converter can be attained to promote the overall performance efficiency of the proposed circuit. Finally, the validity and production availability of the proposed circuit will be verified as well.

  13. SIMULATION ANALYSIS ON PROPORTIONAL INTEGRAL AND DERIVATIVE CONTROL OF CLOSED LOOP DC MOTOR DRIVE WITH BIPOLAR VOLTAGE SWITCHING

    Directory of Open Access Journals (Sweden)

    P. Karpagavalli

    2013-01-01

    Full Text Available This study presents the performance of a new four quadrant single phase DC drive closed loop system controlled by proportional integral and derivative controller with Pulse Width Modulation (PWM full bridge DC-DC converter using bipolar voltage switching. The proposed method is found to be more efficient in improving the step response characteristics such as reducing the settling time, rise time, steady state error and maximum overshoot in speed response of the closed loop DC motor drive and also reduced total harmonics distortion in the AC line current when compared to open loop system. The proposed topologies were simulated using MATLAB/Simulink software package and the results were obtained.

  14. A feasibility study of expert patient and community mental health team led bipolar psychoeducation groups: implementing an evidence based practice

    OpenAIRE

    Coulthard, Katharine; Patel, Dipty; Brizzolara, Clare; Morriss, Richard; Watson, Stuart

    2013-01-01

    Background Group psychoeducation is a cost effective intervention which reduces relapse and improves functioning in bipolar disorder but is rarely implemented. The aim of this study was to identify the acceptability and feasibility of a group psychoeducation programme delivered by community mental health teams (CMHTs) and peer specialist (PS) facilitators. Organisational learning was used to identify and address systematically barriers and enablers, at organisational, health professional and ...

  15. Bidirectional Communication System on Power Line Integrated on Electronic Board for Driving of LED and HID Lamps

    OpenAIRE

    Visconti, P; S. D'Amico; Baschirotto, A.; Romanello, D.; Costantini, P; Ventura, V; Cavalera, G.

    2012-01-01

    We present the bidirectional power line communication system developed in parallel to an electronic board for driving and control of HID (high-intensity discharge) and LED (light-emitting diode) lamps. The communication system, developed to be applied in the sector of public illumination, is been designed to combine high efficiency and reliability with low production costs; it consists indeed of discrete cheap components. The communication system described in this paper implements the techniq...

  16. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob;

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...... the spindle between ParRC complexes on sister plasmids. Using a combination of structural work and total internal reflection fluorescence microscopy, we show that ParRC bound and could accelerate growth at only one end of polar ParM filaments, mechanistically resembling eukaryotic formins. The architecture...... of ParM filaments enabled two ParRC-bound filaments to associate in an antiparallel orientation, forming a bipolar spindle. The spindle elongated as a bundle of at least two antiparallel filaments, thereby pushing two plasmid clusters toward the poles....

  17. Design of Low Power LED Driving Power Supply%低功耗LED驱动电源设计

    Institute of Scientific and Technical Information of China (English)

    朱福超

    2016-01-01

    LED lighting (SSL:Solid State Lighting) has provided new lighting products for the users all over the world. LED needs independent driving power supply to light. It is a trend to replace the traditional lighting with LED. To reduce the cost and power-consumption of LED is a shortcut for LED to replace the traditional lighting. Through analysis and selection of various topologies, this paper chooses driver chip as the case to introduce the design method of low power LED driver.%LED照明(SSL:Solid State Lighting)为全世界用户提供了新的照明产品。LED必须有独立的驱动电源才能使其点亮发光。LED替代传统照明成为一种趋势,如果降低LED成本,降低LED功耗更是顺利替代传统照明的一条捷径。本文通过对各种拓扑结构的分析和选择,从而选择驱动芯片,最后以具体驱动芯片为案例,详细介绍低功耗LED驱动器的设计方法。

  18. 无线LED照明驱动系统方案设计%Drive system design of wireless LED lighting

    Institute of Scientific and Technical Information of China (English)

    唐嘉铭; 郑阳; 李晖; 李志芳

    2014-01-01

    本文主要提出以电磁耦合与电磁共振的方式,为LED提供无线驱动电能。采用高精度的正激变换恒流源驱动LED,并利用光电池进行光照强度采集反馈调整恒流源电流以控制LED发光强度,保证光照恒定。此外该系统还在电网输入端增加有源电力滤波器(Active Power Filter,APF),以减少该装置作为非线性负载而引入电网的高次谐波。本文所述方案能有效地提高LED照明分布的灵活性,解决电力线布线的繁琐,同时在高效管理光照能耗的情况下不影响电网电能质量,因此其具有深厚的实用价值和应用潜力。%This paper mainly introduces a LED drive system with wireless power supply in electromagnet coupling or electromagnetic resonance mode. The high-precision current source is adopted to drive LED (s) whose luminous intensity is controlled by source current according to light intensity feedback via photocell, so as to ensure stable illumination. What’s more, the system also increases active power filter (APF) beside grid input, which may prevent harmonics produced by this nonlinear device from injecting electric network. The program presented can effectively improve the flexibility of LED lighting distribution, and solve the trouble of cable wiring. It may provide efficient management of light energy without affecting power quality of the grid. So that it has profound practical value and application potential.

  19. Types of Bipolar Disorder

    Science.gov (United States)

    ... improve the lives of people who have mood disorders. The Power of Peers DBSA envisions wellness for people who live with depression and bipolar disorder. Because DBSA was created for and is led ...

  20. Design and preliminary results for a fast bipolar resonant discharge pulser using SCR switches for driving the injection bump magnets at the ALS

    International Nuclear Information System (INIS)

    A fast (4.0 μs half period) resonant discharge pulser using SCRs has been designed and constructed to drive the injection bump magnet system at the Advanced Light Source (ALS). The pulser employs a series-parallel arrangement of Silicon Controlled Rectifiers (SCRs) that create a bipolar high voltage (+/- 10 KV), high peak current (6600 amps.) and a high di/dt (6000 amp/μs) switch network that discharges a capacitor bank into the magnet load. Fast recovery diodes in series with the SCRs significantly reduce the SCR turn-off during the negative current cycle of the magnet. The SCR switch provides a very reliable and stable alternative to the gas filled Thyratron. A very low impedance transmission system allows the pulser system to reside completely outside the storage ring shielding wall

  1. Design and preliminary results for a fast bipolar resonant discharge pulser using SCR switches for driving the injection bump magnets at the ALS

    International Nuclear Information System (INIS)

    A fast (4.0 us half period) resonant discharge pulser using SCRs has been designed and constructed to drive the injection bump magnet system at the Advanced Light Source (ALS). The pulser employs a series-parallel arrangement of Silicon Controlled Rectifiers (SCRS) that creates a bipolar high voltage (±10 KV), high peak current (6600 amps.) and a high di/dt (6000 amp/us) switch network that discharges a capacitor bank into the magnet load. Fast recovery diodes in series with the SCRs significantly reduces the SCR turn-off time during the negative current cycle of the magnet. The SCR switch provides a very reliable and stable alternative to the gas filled Thyratron. A very low impedance transmission system allows the pulser system to reside completely outside the storage ring shielding wall

  2. Driving Down HB-LED Costs. Implementation of Process Simulation Tools and Temperature Control Methods of High Yield MOCVD Growth

    Energy Technology Data Exchange (ETDEWEB)

    Quinn, William [Veeco Process Equipment, Inc., Plainview, NY (United States)

    2012-04-30

    The overall objective of this multi-faceted program is to develop epitaxial growth systems that meet a goal of 75% (4X) cost reduction in the epitaxy phase of HB-LED manufacture. A 75% reduction in yielded epitaxy cost is necessary in order to achieve the cost goals for widespread penetration of HB-LED's into back-lighting units (BLU) for LCD panels and ultimately for solid-state lighting (SSL). To do this, the program will address significant improvements in overall equipment Cost of Ownership, or CoO. CoO is a model that includes all costs associated with the epitaxy portion of production. These aspects include cost of yield, capital cost, operational costs, and maintenance costs. We divide the program into three phases where later phases will incorporate the gains of prior phases. Phase one activities are enabling technologies. In collaboration with Sandia National Laboratories we develop a Fluent-compatible chemistry predictive model and a set of mid-infrared and near-ultraviolet pyrometer monitoring tools. Where previously the modeling of the reactor dynamics were studied within FLUENT alone, here, FLUENT and Chemkin are integrated into a comprehensive model of fluid dynamics and the most advanced transport equations developed for Chemkin. Specifically, the Chemkin model offered the key reaction terms for gas-phase nucleation, a key consideration in the optimization of the MOCVD process. This new predictive model is used to design new MOCVD reactors with optimized growth conditions and the newly developed pyrometers are used monitor and control the MOCVD process temperature to within 0.5°C run-to-run and within each wafer. This portion of the grant is in collaboration with partners at Sandia National Laboratories. Phase two activities are continuous improvement projects which extend the current reactor platform along the lines of improved operational efficiency, improved systems control for throughput, and carrier modifications for increased yield

  3. Bipolar Disorder

    Science.gov (United States)

    Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go ... The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. ...

  4. Bipolar Disorder

    Science.gov (United States)

    Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They ... The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in ...

  5. Bipolar Disorder

    Science.gov (United States)

    ... types of psychotherapies. Other Treatment Options Electroconvulsive Therapy (ECT) : ECT can provide relief for people with severe bipolar ... been able to recover with other treatments. Sometimes ECT is used for bipolar symptoms when other medical ...

  6. Bipolar semicopulas

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    Linz: Univesitatsdirektion, JKU Linz, Austria, 2013. s. 63-65. [Linz Seminar on Fuzzy Set Theory /34./. 26.02.2013-02.03.2013, Linz] R&D Projects: GA ČR GAP402/11/0378 Keywords : bipolar integral * bipolar semicopula * bipolar aggregation Subject RIV: BA - General Mathematics http://library.utia.cas.cz/separaty/2013/E/mesiar-0422906.pdf

  7. 100W风光互补LED路灯驱动电路设计%Design of drive circuit for 100 W wind-solar complementary LED street lamp

    Institute of Scientific and Technical Information of China (English)

    杨赫博; 付贤松; 牛萍娟

    2014-01-01

    随着节能环保产品的推广,风光互补LED路灯以其独特的优势走入了人们的视野。风光互补系统和LED路灯的结合对LED驱动电路的设计产生了很大的挑战。目前采用单开关管DC/DC LED驱动控制器进行供电虽然能满足要求,但是功率不能达到很高,并且不能实现输出短路保护功能。为了输出短路保护功能并且达到较高的功率,设计了一种基于LT3791的4开关Buck-Boost DC/DC LED驱动控制器。此电路可由12/24 V蓄电池供电,输出功率可达100 W,恒流精度可达到±6%,效率可高达98.5%。输出能够达到70 V/2 A。该设计经测试能够达到设计要求,在实际生活中应用来满足夜晚照明需求。%With the promotion of energy saving and environmental protection products,the wind-solar complementary LED street lamp has entered people's vision by the aid of its unique advantages. The combination of wind-solar complementation and LED street lamp evoked a great challenge for the design of LED driver circuit. The DC/DC LED drive controller with simple switching tube cannot reach very high power,and can not realize the functon of output short circuit protection though it can meet the power supply requirements currently. In order to achieve output short circuit protection and high power,a 4-switch Buck-Boost DC / DC LED driver controller based on LT3791 was designed in this paper. This circuit can be powered by 12/24 V storage battery,whose output power can be up to 100 W,constant current precision can reach ± 6%,efficiency can be up to 98.5% and output can reach 50 V/2 A. This design was tested. It satisfied the design requirements and the night lighting needs in real life.

  8. Bipolar Disorder.

    Science.gov (United States)

    Spearing, Melissa

    Bipolar disorder, a brain disorder that causes unusual shifts in a person's mood, affects approximately one percent of the population. It commonly occurs in late adolescence and is often unrecognized. The diagnosis of bipolar disorder is made on the basis of symptoms, course of illness, and when possible, family history. Thoughts of suicide are…

  9. Bipolar disorder.

    Science.gov (United States)

    Grande, Iria; Berk, Michael; Birmaher, Boris; Vieta, Eduard

    2016-04-01

    Bipolar disorder is a recurrent chronic disorder characterised by fluctuations in mood state and energy. It affects more than 1% of the world's population irrespective of nationality, ethnic origin, or socioeconomic status. Bipolar disorder is one of the main causes of disability among young people, leading to cognitive and functional impairment and raised mortality, particularly death by suicide. A high prevalence of psychiatric and medical comorbidities is typical in affected individuals. Accurate diagnosis of bipolar disorder is difficult in clinical practice because onset is most commonly a depressive episode and looks similar to unipolar depression. Moreover, there are currently no valid biomarkers for the disorder. Therefore, the role of clinical assessment remains key. Detection of hypomanic periods and longitudinal assessment are crucial to differentiate bipolar disorder from other conditions. Current knowledge of the evolving pharmacological and psychological strategies in bipolar disorder is of utmost importance. PMID:26388529

  10. : Genetic heterogeneity of bipolar disorder

    OpenAIRE

    Mathieu, Flavie; Dizier, Marie-Hélène; Etain, Bruno; Jamain, Stéphane; Rietschel, Marcella; Maier, Wolfgang; Albus, Margot; Mckeon, Patrick; Roche, Siobhan; Blackwood, Douglas; Muir, Walter,; Henry, Chantal; Malafosse, Alain; Preisig, Martin; Ferrero, François

    2010-01-01

    Bipolar disorder has a genetic component, but the mode of inheritance remains unclear. A previous genome scan conducted in 70 European families led to detect eight regions linked to bipolar disease. Here, we present an investigation of whether the phenotypic heterogeneity of the disorder corresponds to genetic heterogeneity in these regions using additional markers and an extended sample of families. The MLS statistic was used for linkage analyses. The predivided sample test and the maximum l...

  11. Bipolar Disorder

    Science.gov (United States)

    ... lows). These aren't the normal periods of happiness and sadness that everyone experiences from time to ... with long-lasting medical conditions (such as asthma , diabetes , or epilepsy ), teens with bipolar disorder need to ...

  12. Bipolar disorder

    OpenAIRE

    Goodwin, Frederick K; Ghaemi, S Nassir

    1999-01-01

    Bipolar disorder's unique combination of three characteristics - clear genetic diathesis, distinctive clinical features, early availability of an effective treatment (lithium) - explains its special place in the history of psychiatry and its contribution to the current explosive growth of neuroscience. This article looks at the state of the art in bipolar disorder from the vantage point of: (i) genetics (possible linkages on chromosomes 18 and 21q, polygenic hypothesis, research into genetic ...

  13. On Bipolar Soft Sets

    OpenAIRE

    Shabir, Muhammad; Naz, Munazza

    2013-01-01

    We have studied the concept of bipolarity of information in the soft sets. We have defined bipolar soft sets and basic operations of union, intersection and complementation for bipolar soft sets. Examples of bipolar soft sets and an application of bipolar soft sets in a decision making problem with general algorithms have also been presented at the end.

  14. Cayley Bipolar Fuzzy Graphs

    OpenAIRE

    Alshehri, Noura O.; Muhammad Akram

    2013-01-01

    We introduce the concept of Cayley bipolar fuzzy graphs and investigate some of their properties. We present some interesting properties of bipolar fuzzy graphs in terms of algebraic structures. We also discuss connectedness in Cayley bipolar fuzzy graphs.

  15. Transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Alda Martin

    1999-01-01

    Full Text Available Os resultados de estudos de famílias sugerem que o transtorno bipolar tenha uma base genética. Essa hipótese foi reforçada em estudos de adoção e de gêmeos. A herança do transtorno bipolar é complexa, envolve vários genes, além de apresentar heterogeneidade e interação entre fatores genéticos e não-genéticos. Achados, que já foram replicados, já implicaram os cromossomos 4, 12, 18 e 21, entre outros, na busca por genes de suscetibilidade. Os resultados mais promissores foram obtidos através de estudos de ligação. Por outro lado, os estudos de associação geraram dados interessantes, mas ainda vagos. Os estudos de populações de pacientes homogêneos e a melhor definição do fenótipo deverão contribuir para avanços futuros. A identificação dos genes relacionados ao transtorno bipolar irá permitir o melhor entendimento e tratamento dessa doença.

  16. Integrated neurobiology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Vladimir eMaletic

    2014-08-01

    Full Text Available From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity—reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition—limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional unified field theory of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial-neuronal interactions. Among these glial elements are microglia—the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the HPA axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of bipolarity is one of the great

  17. LED wireless

    OpenAIRE

    Pang, G.; Kwan, T.; Liu, H; Chan, CH

    2002-01-01

    High-brightness light-emitting diodes (LEDs) are getting more popular and are opening up a number of new applications. In this paper, the novel idea based on the fast switching of LEDs and the modulation of visible light is developed into a new kind of information system. A visible-LED audio system that makes use of visual-light rays to transmit audio messages to a remotely located receiver is described. Such a system made up of high-brightness visible LEDs can provide the function of open sp...

  18. Vacuum interface flashover with bipolar electric fields

    International Nuclear Information System (INIS)

    High energy, compact, particle accelerators require accelerating cavities that have large gradients and operate with high efficiency. The bipolar electric fields necessary in these efficient accelerating cavities place severe requirements on the insulator-vacuum interface. A new interface has been designed and 50 gv/cm bipolar flashover field achieved for a waveform train that lasted 1 μs. This paper discusses the design of this vacuum interface and the evaluation of various materials that led to achieving bipolar flashover fields 50% greater than the authors had previously obtained

  19. Neutrality in bipolar structures

    DEFF Research Database (Denmark)

    Montero, Javier; Rodríguez, J. Tinguaro; Franco, Camilo;

    2014-01-01

    In this paper, we want to stress that bipolar knowledge representation naturally allows a family of middle states which define as a consequence different kinds of bipolar structures. These bipolar structures are deeply related to the three types of bipolarity introduced by Dubois and Prade, but o...

  20. Is There a Bipolar Prodrome Among Children and Adolescents?

    Science.gov (United States)

    Hunt, Jeffrey; Schwarz, Charlotte M; Nye, Paul; Frazier, Elisabeth

    2016-04-01

    Bipolar disorder in youth substantially impairs behavior, family, and social functioning and interferes with developmental course. There is increasing interest in defining a bipolar prodrome similar to that reported in early-onset psychosis that will allow for earlier intervention and reduction in overall morbidity and mortality. Several lines of research have addressed this important issue including studies of offspring of bipolar parents, high-risk cohorts, and longitudinal follow-up of subjects with major depressive disorder (MDD), ADHD, and bipolar spectrum disorder. The development and validation of bipolar prodrome rating scales also shows promise. Recent attempts to intervene at earlier stages of bipolar disorder have led to some positive outcomes. However, a controversy remains concerning the identification and management of the earliest symptoms. Further research is needed to fully validate a bipolar prodrome and to determine the optimal course of action at various stages of illness. PMID:26893233

  1. Discrete bipolar universal integrals

    OpenAIRE

    Greco, Salvatore; Mesiar, Radko; Rindone, Fabio

    2014-01-01

    The concept of universal integral, recently proposed, generalizes the Choquet, Shilkret and Sugeno integrals. Those integrals admit a discrete bipolar formulation, useful in those situations where the underlying scale is bipolar. In this paper we propose the concept of discrete bipolar universal integral, in order to provide a common framework for bipolar discrete integrals, including as special cases the discrete Choquet, Shilkret and Sugeno bipolar integrals. Moreover we provide two differe...

  2. Analysis on Guangdong ’s patent competitive power with LED driving power source%广东省LED驱动电源专利竞争力分析

    Institute of Scientific and Technical Information of China (English)

    蓝燕

    2014-01-01

    Utilizing the internet search database - the SooPat database of the State Intelligence Property Office (SIPO) of the P.R.C, a patent database about LED driving power source is established by retrieving the patent documents applied dating from Jan. 1st 2004 to Feb. 31st 2013. Then using the patent information analysis platform system of the SIPO, a refined and comprehensive analysis on the competitive power of Huizhou ’s patent application is carried out with respect to the application region distribution, the IPC distribution, and the applier distribution. A patent strategy about how to develop the technology of LED driving power source is pro-posed at last.%利用国家知识产权局互联网检索数据库SooPat专利数据库,采集2004年1月1日至2013年12月31日期间的LED驱动电源技术专利文献,建立LED驱动电源专利数据库。再选择国家知识产权局专利信息服务平台分析系统分别从专利申请区域分布、IPC技术类别分布和专利申请人分布等方面,对LED 驱动电源技术专利进行了深入的分析,提出了发展广东省LED驱动电源技术的专利策略。

  3. LED lamp

    Energy Technology Data Exchange (ETDEWEB)

    Galvez, Miguel; Grossman, Kenneth; Betts, David

    2013-11-12

    There is herein described a lamp for providing white light comprising a plurality of light sources positioned on a substrate. Each of said light sources comprises a blue light emitting diode (LED) and a dome that substantially covers said LED. A first portion of said blue light from said LEDs is transmitted through said domes and a second portion of said blue light is converted into a red light by a first phosphor contained in said domes. A cover is disposed over all of said light sources that transmits at least a portion of said red and blue light emitted by said light sources. The cover contains a second phosphor that emits a yellow light in response to said blue light. The red, blue and yellow light combining to form the white light and the white light having a color rendering index (CRI) of at least about 80.

  4. Generalized bipolar product and sum

    OpenAIRE

    Greco, Salvatore; Mesiar, Radko; Rindone, Fabio

    2016-01-01

    Aggregation functions on [0, 1] with annihilator 0 can be seen as a generalized product on [0, 1]. We study the generalized product on the bipolar scale [−1, 1], stressing the axiomatic point of view ( compare also [9]). Based on newly introduced bipolar properties, such as the bipolar increasingness, bipolar unit element, bipolar idempotent element, several kinds of generalized bipolar product are introduced and studied. A special stress is put on bipolar semicopulas, bipolar quasi-copulas a...

  5. Help With Bipolar Disorders

    Science.gov (United States)

    ... a Psychiatrist Patients & Families All Topics Help With Bipolar Disorders Curated and updated for the community by APA Topic Information Bipolar disorders are brain disorders that cause changes in a ...

  6. 基于线性高压恒流驱动的智能LED灯设计%An Intelligent LED Lamp Design Based on Linear High-voltage Constant Current Drive

    Institute of Scientific and Technical Information of China (English)

    徐志春; 徐根达

    2015-01-01

    This paper presents a intelligent LED products, which include Bluetooth 4 BLE module, power module and linear voltage constant current driver chip. Inteligent LED lamp can communicate with smart phones by the embedded Bluetooth 4.0 BLE module,at same time which can obtain th light and the color con⁃trol command through the IIC protocol and the linear voltage constant current drive chip interface.The scheme use non-isolation linear voltage constant and use SM2135 chip to adjust the light and dimme the color of LED lamp. The design of intelligent LED lighting control circuit is simple, high power factor, low cost, flexible control features,which can be flexible to choose the way of lighting and fully reflets the intelligence and per⁃sonality characteristics of intelligent LED lamp.%文章设计了一款智能LED产品,该产品包括了蓝牙4.0 BLE模块、电源模块和线性高压恒流驱动芯片。智能LED灯内嵌的蓝牙4.0 BLE模块实现和智能手机的通信,同时通过IIC协议和线性高压恒流驱动芯片接口,获取LED灯的调光调色控制命令。采用非隔离线性高压恒流驱动方案,利用芯片SM2135的PWM技术实现LED灯的调光调色。该方案设计的智能LED灯具有控制电路简单、功率因数高、成本低、控制灵活的特点,通过具有蓝牙功能的智能手机可以自由选择照明方式,充分体现了智能LED灯的智能化和个性化特点。

  7. Staging Bipolar Disorder.

    OpenAIRE

    Vieta i Pascual, Eduard, 1963-; Reinares, M.; Rosa, A. R.

    2011-01-01

    The purpose of this study was to analyze the evidence supporting a staging model for bipolar disorder. The authors conducted an extensive Medline and Pubmed search of the published literature using a variety of search terms (staging, bipolar disorder, early intervention) to find relevant articles, which were reviewed in detail. Only recently specific proposals have been made to apply clinical staging to bipolar disorder. The staging model in bipolar disorder suggests a progression from prodro...

  8. Cytokines in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Vedel Kessing, Lars

    2012-01-01

    BACKGROUND: Current research and hypothesis regarding the pathophysiology of bipolar disorder suggests the involvement of immune system dysfunction that is possibly related to disease activity. Our objective was to systematically review evidence of cytokine alterations in bipolar disorder according...... to affective state. METHODS: We conducted a systemtic review of studies measuring endogenous cytokine concentrations in patients with bipolar disorder and a meta-analysis, reporting results according to the PRISMA statement. RESULTS: Thirteen studies were included, comprising 556 bipolar disorder...

  9. Management of Bipolar Depression

    OpenAIRE

    Jae Seung Chang; Kyooseob Ha

    2011-01-01

    Patients with bipolar disorder spend more time in a depressed than manic state, even with individualized treatment. To date, bipolar depression is often misdiagnosed and ineffectively managed both for acute episodes and residual symptoms. This review attempts to summarize the current status of available treatment strategies in the treatment of bipolar depression. For acute and prophylactic treatment, a substantial body of evidence supports the antidepressive efficacy of lithium for bipolar di...

  10. Bipolar Fuzzy Integrals

    OpenAIRE

    Greco, Salvatore; Rindone, Fabio

    2012-01-01

    In decision analysis and especially in multiple criteria decision analysis, several non additive integrals have been introduced in the last sixty years. Among them, we remember the Choquet integral, the Shilkret integral and the Sugeno integral. Recently, the bipolar Choquet integral has been proposed for the case in which the underlying scale is bipolar. In this paper we propose the bipolar Shilkret integral and the bipolar Sugeno integral. Moreover, we provide an axiomatic characterization ...

  11. Irregular Bipolar Fuzzy Graphs

    OpenAIRE

    Samanta, Sovan; Pal, Madhumangal

    2012-01-01

    In this paper, we define irregular bipolar fuzzy graphs and its various classifications. Size of regular bipolar fuzzy graphs is derived. The relation between highly and neighbourly irregular bipolar fuzzy graphs are established. Some basic theorems related to the stated graphs have also been presented.

  12. Costs of Bipolar Disorder

    OpenAIRE

    Leah S. Kleinman; Ana Lowin; Emuella Flood; Gian Gandhi; Eric Edgell; Revicki, Dennis A

    2003-01-01

    Bipolar disorder is a chronic affective disorder that causes significant economic burden to patients, families and society. It has a lifetime prevalence of approximately 1.3%. Bipolar disorder is characterised by recurrent mania or hypomania and depressive episodes that cause impairments in functioning and health-related quality of life. Patients require acute and maintenance therapy delivered via inpatient and outpatient treatment. Patients with bipolar disorder often have contact with the s...

  13. Treatment Resistant Bipolar Disorder

    OpenAIRE

    Elvan Ozalp; Ersin Hatice Karslioglu

    2015-01-01

    Many patients diagnosed with bipolar disorder respond incompletely or unsatisfactorily to available treatments. Defining refractoriness in bipolar disorder is a complex issue and should concern and include either every phase and pole or the disorder as a whole. There are only limited and sometimes confusing data on the treatment of refractory bipolar patients. The objective of this paper was to review the evidence for treatment options in treatment resistant patients on depressive, manic atta...

  14. Bipolar Affective Disorder and Migraine

    OpenAIRE

    Birk Engmann

    2012-01-01

    This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and ...

  15. Managing bipolar moods without medication:a qualitative investigation

    OpenAIRE

    Cappleman, Reed; Smith, Ian; Lobban, Fiona

    2015-01-01

    Objectives Although many diagnosed with Bipolar Disorder (BD) choose to manage their moods without medication at some point, their experiences of doing so are not well understood. This paper aims to explore the processes by which people manage bipolar moods without medication. Methods Ten people diagnosed with BD who do not use medication were interviewed. Analysing their accounts using grounded theory methods led to developing a model of how they perceive the processes involved in managing m...

  16. Properties of Bipolar Fuzzy Hypergraphs

    OpenAIRE

    Akram, M.; Dudek, W. A.; Sarwar, S.

    2013-01-01

    In this article, we apply the concept of bipolar fuzzy sets to hypergraphs and investigate some properties of bipolar fuzzy hypergraphs. We introduce the notion of $A-$ tempered bipolar fuzzy hypergraphs and present some of their properties. We also present application examples of bipolar fuzzy hypergraphs.

  17. Neuroinflammation in bipolar disorders

    Directory of Open Access Journals (Sweden)

    Georgios D Kotzalidis

    2015-01-01

    Full Text Available Recent literature based on peripheral immunity findings speculated that neuroinflammation, with its connection to microglial activation, is linked to bipolar disorder. The endorsement of the neuroinflammatory hypotheses of bipolar disorder requires the demonstration of causality, which requires longitudinal studies. We aimed to review the evidence for neuroinflammation as a pathogenic mechanism of the bipolar disorder. We carried out a hyper inclusive PubMed search using all appropriate neuroinflammation-related terms and crossed them with bipolar disorder-related terms. The search produced 310 articles and the number rose to 350 after adding articles from other search engines and reference lists. Twenty papers were included that appropriately tackled the issue of the presence (but not of its pathophysiological role of neuroinflammation in bipolar disorder. Of these, 15 were postmortem and 5 were carried out in living humans. Most articles were consistent with the presence of neuroinflammation in bipolar disorder, but factors such as treatment may mask it. All studies were cross-sectional, preventing causality to be inferred. Thus, no inference can be currently made about the role of neuroinflammation in bipolar disorder, but a link is likely. The issue remains little investigated, despite an excess of reviews on this topic.

  18. Advanced poly-LED displays

    Science.gov (United States)

    Childs, Mark; Nisato, Giovanni; Fish, D.; Giraldo, Andrea; Jenkins, A. J.; Johnson, Mark T.

    2003-05-01

    Philips have been actively developing polymer OLED (poly-LED) displays as a future display technology. Their emissive nature leads to a very attractive visual appearance, with wide viewing angle, high brightness and fast response speed. Whilst the first generation of poly-LED displays are likely to be passive-matrix driven, power reduction and resolution increase will lead to the use of active-matrix poly-LED displays. Philips Research have designed, fabricated and characterized five different designs of active-matrix polymer-LED display. Each of the five displays makes use of a distinct pixel programming- or pixel drive-technique, including current programming, threshold voltage measurement and photodiode feedback. It will be shown that hte simplest voltage-programmed current-source pixel suffers from potentially unacceptable brightness non-uniformity, and that advanced pixel circuits can provide a solution to this. Optical-feedback pixel circuits will be discussed, showing that they can be used to improve uniformity and compensate for image burn-in due to polymer-LED material degradation, improving display lifetime. Philips research has also been active in developing technologies required to implement poly-LED displays on flexible substrates, including materials, processing and testing methods. The fabrication of flexible passive-matrix poly-LED displays will be presented, as well as the ongoing work to assess the suitability of processing flexible next-generation poly-LED displays.

  19. Bipolar membrane characterization

    Czech Academy of Sciences Publication Activity Database

    Richau, K.; Kůdela, Vlastimil

    Enschede : Twente University Press, 2001 - (Kemperman, A.), s. 112-147 ISBN 903651523 R&D Projects: GA MŠk ME 079 Keywords : bipolar membranes * water dissociation * methods for characterisation Subject RIV: CD - Macromolecular Chemistry

  20. 双极式控制直流PWM-M可逆调速系统的建模与仿真%The Modeling and Simulation of Bipolar Reversible PWM-M DC Drive System

    Institute of Scientific and Technical Information of China (English)

    吴祥营; 荣军; 孙敏敏; 朱珊珊; 杨铮

    2013-01-01

      阐述了双极式控制直流PWM-M调速系统的工作原理,并且详细研究了在Matlab/Simulink中的双极式控制直流PWM-M调速系统的建模方法,最后给出了反映系统性能的仿真结果并对其进行了比较分析,对双极式控制直流PWM-M可逆调速系统在实际工程中的应用有很好的借鉴意义。%This paper introduces the working principle of bipolar reversible PWM-M DC speed control system, and makes a detailed study of the modeling method of the speed control system in Matlab/Simulink. At last, the paper gives the simulation results and makes a comparative analysis for reflecting the system performance, which has a good reference for the application of bipolar DC PWM-M reversible speed control system in engineering.

  1. Mechanism on bipolar distribution of Permian brachiopods

    Institute of Scientific and Technical Information of China (English)

    Chengwen WANG; Songmei ZHANG

    2008-01-01

    By reasearch on geographic distribution, nine genera in bipolar distribution are selected from Permian brachiopods. These taxa originated from middle-high latitude areas in the boreal realm, of which five genera were derived from Late Carboniferous, and other four genera originated from Permian. They were all in bipolar distribution during some different stages in Permian. Specific diversity for each genus was high in the boreal realm, whereas in the Gondwana realm was very low. Perdurability was long in the boreal realm, and short in the Gondwana realm. It was the time when these nine genera came to their maximum diversity that these genera appeared in the Gondwana and formed bipolar distribution; while they also migrated to the low latitude from high latitude. This shows very close relationship between several main cooling events in Permian and the migration of genera from the boreal realm to the Gondwana realm through the Tethys. Therefore, the cooling events might be the main drive which caused these cold-water-type brachiopods migrated to the Gondwana realm and being bipolar distribution. In this process, the planula tolerance to warm water would be another important factor.

  2. Variable-speed drive and control systems for rolling mills; Atsuenkiyo drive seigyo system

    Energy Technology Data Exchange (ETDEWEB)

    Kasai, T.; Tochigi, T. [Fuji Electric Co. Ltd., Tokyo (Japan)

    2000-11-10

    The drive systems of large rolling mills is of a cycloconverter type, a GTO (gate turn-off thyristor) type or high-voltage IGBT (insulated gate bipolar transistor) type. Drive systems for bar, rod and pipe mills use three and/or two level IGBT inverters. This paper describes recent technical trends of drives and control systems in rolling mills, including each drive application and the PLC (programmable controller) and HCI (human communication interface) controlling the total rolling mill line. (author)

  3. Vacuum interface flashover with bipolar electric fields

    Energy Technology Data Exchange (ETDEWEB)

    Tucker, W.K.; Anderson, R.A.; Hasti, D.E.; Jones, E.E.; Bennett, L.F.

    1985-05-01

    High energy, compact, particle accelerators require accelerating cavities that have large gradients and operate with high efficiency. The bipolar electric fields required in these efficient accelerating cavities place severe requirements on the vacuum interface. Experimentally, we have found that the bipolar flashover field varies as t/sup -1/2/ for times out to 300 ns and then remains essentially constant at 33 kV/cm for longer duration waveforms, whereas materials subjected to unipolar electric fields follow a t/sup -1/6/ relationship. Furthermore, specific accelerating cavities offer enhancements that may be employed to achieve highly uniform electric fields across the vacuum interface. Using these results and the results of a previously developed theory of unipolar flashover, a new interface has been designed and 50 kV/cm bipolar flashover field achieved for a waveform train that lasted 1 ..mu..s. This paper will discuss the design of this vacuum interface and the evaluation of various materials that led to achieving bipolar flashover fields 50% greater than we had previously obtained for long duration waveforms. 10 refs., 6 figs.

  4. Vacuum interface flashover with bipolar electric fields

    International Nuclear Information System (INIS)

    High energy, compact, particle accelerators require accelerating cavities that have large gradients and operate with high efficiency. The bipolar electric fields required in these efficient accelerating cavities place severe requirements on the vacuum interface. Experimentally, we have found that the bipolar flashover field varies as t/sup -1/2/ for times out to 300 ns and then remains essentially constant at 33 kV/cm for longer duration waveforms, whereas materials subjected to unipolar electric fields follow a t/sup -1/6/ relationship. Furthermore, specific accelerating cavities offer enhancements that may be employed to achieve highly uniform electric fields across the vacuum interface. Using these results and the results of a previously developed theory of unipolar flashover, a new interface has been designed and 50 kV/cm bipolar flashover field achieved for a waveform train that lasted 1 μs. This paper will discuss the design of this vacuum interface and the evaluation of various materials that led to achieving bipolar flashover fields 50% greater than we had previously obtained for long duration waveforms. 10 refs., 6 figs

  5. Reduced Component Count RGB LED Driver

    NARCIS (Netherlands)

    De Pedro, I.; Ackermann, B.

    2008-01-01

    The goal of this master thesis is to develop new drive and contrololutions, for creating white light from mixing the light of different-color LEDs, aiming at a reduced component count resulting in less space required by the electronics and lower cost. It evaluates the LED driver concept proposed in

  6. Bipolar Affective Disorder and Migraine

    Directory of Open Access Journals (Sweden)

    Birk Engmann

    2012-01-01

    Full Text Available This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and bipolar disorder, including both genetic and neuropathological approaches, is broadly discussed. Moreover, bipolar disorder and migraine are often combined with a variety of other affective disorders, and, furthermore, behavioural factors also play a role in the origin and course of the diseases. Approach to treatment options is also difficult. Several papers point out possible remedies, for example, valproate, topiramate, which acts on both diseases, but no first-choice treatments have been agreed upon yet.

  7. Lightweight bipolar storage battery

    Science.gov (United States)

    Rowlette, John J. (Inventor)

    1992-01-01

    An apparatus [10] is disclosed for a lightweight bipolar battery of the end-plate cell stack design. Current flow through a bipolar cell stack [12] is collected by a pair of copper end-plates [16a,16b] and transferred edgewise out of the battery by a pair of lightweight, low resistance copper terminals [28a,28b]. The copper terminals parallel the surface of a corresponding copper end-plate [16a,16b] to maximize battery throughput. The bipolar cell stack [12], copper end-plates [16a,16b] and copper terminals [28a,28b] are rigidly sandwiched between a pair of nonconductive rigid end-plates [20] having a lightweight fiber honeycomb core which eliminates distortion of individual plates within the bipolar cell stack due to internal pressures. Insulating foam [30] is injected into the fiber honeycomb core to reduce heat transfer into and out of the bipolar cell stack and to maintain uniform cell performance. A sealed battery enclosure [ 22] exposes a pair of terminal ends [26a,26b] for connection with an external circuit.

  8. LED-LED portable oxygen gas sensor

    OpenAIRE

    Perez de Vargas Sansalvador, Isabel; Fay, Cormac; Fernandez-Ramos, M.D.; Diamond, Dermot; Benito-Lopez, Fernando; Capitan-Vallvey, L.F.

    2012-01-01

    A portable instrument for oxygen determination, based on the quenching of phosphorescent octaethylporphyrin by gaseous O2, has been developed using the fluorimetric paired emitter–detector diode technique (FPEDD). The instrument configuration used consists of two light emitting diodes (LEDs) facing each other including an interchangeable support containing a phosphorescent membrane in between, in which one of the LEDs is used as the light source (emitter LED) and the other working in reverse...

  9. Bipolar battery construction

    Science.gov (United States)

    Rippel, Wally E. (Inventor); Edwards, Dean B. (Inventor)

    1981-01-01

    A lightweight, bipolar battery construction for lead acid batteries in which a plurality of thin, rigid, biplates each comprise a graphite fiber thermoplastic composition in conductive relation to lead stripes plated on opposite flat surfaces of the plates, and wherein a plurality of nonconductive thermoplastic separator plates support resilient yieldable porous glass mats in which active material is carried, the biplates and separator plates with active material being contained and maintained in stacked assembly by axial compression of the stacked assembly. A method of assembling such a bipolar battery construction.

  10. The bipolar universal integral

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    Heidelberg: Springer, 2012 - (Greco, S.; Bouchon-Meunier, B.; Coletti, G.; Fedrizzi, M.; Matarazzo, B.; Yager, R.), s. 360-369. (Communications in Computer and Information Science. 299). ISBN 978-3-642-31717-0. ISSN 1865-0929. [IPMU 2012 /14./. Catania (IT), 09.07.2012-13.07.2012] R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * Choquet integral * universal integral Subject RIV: BA - General Mathematics http://library.utia.cas.cz/separaty/2012/E/mesiar-the%20bipolar%20universal%20integral.pdf

  11. Abordagens psicoterápicas no transtorno bipolar Psychoterapeutic approach in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Paulo Knapp

    2005-01-01

    Full Text Available Embora o tratamento farmacológico seja essencial para o tratamento do transtorno bipolar, apenas 40% de todos os pacientes que aderem às medicações permanecem assintomáticos durante o período de seguimento, o que tem levado ao desenvolvimento de intervenções psicoterápicas associadas. O objetivo deste artigo é examinar as evidências atuais da eficácia de intervenções psicoterápicas no tratamento do transtorno bipolar. Foi realizada uma pesquisa bibliográfica por meio do MedLine, PsychoINFO, Lilacs e Cochrane Data Bank, até o ano de 2004, em que foram procurados artigos originais e revisões sobre as abordagens psicoterápicas utilizadas no tratamento do transtorno bipolar. Há várias abordagens que podem se mostrar úteis no tratamento do transtorno bipolar. A psicoeducação e a terapia cognitivo-comportamental apresentam as evidências mais consistentes e são as técnicas mais amplamente estudadas. As intervenções envolvendo familiares e a terapia interpessoal e de ritmo social se mostram tratamentos eficazes em determinadas situações. Há alguns estudos empregando a terapia psicodinâmica no transtorno bipolar, mas são estudos com limitações metodológicas. Apesar de haver evidências demonstrando a eficácia de determinadas abordagens psicoterápicas no transtorno bipolar, ainda é necessária a realização de estudos posteriores que comprovem tais dados e que desenvolvam tratamentos baseados em modelos etiológicos e que identifiquem tratamentos específicos para as diferentes fases e tipos de transtorno bipolar.Although pharmacological treatment is essential for treating bipolar disorder, less than half of all medication compliant patients are non-symptomatic during follow-up, which has led to developments of adjunctive psychosocial interventions. This paper examines the current evidence for effectiveness of psychotherapeutic interventions in the treatment of bipolar disorder. Searches were undertaken through Med

  12. Bipolar Disorder in Turkey

    Directory of Open Access Journals (Sweden)

    Bulent Kadri Gultekin

    2014-06-01

    Full Text Available Assessment of studies related with bipolar disorder in Turkey did not reveal an epidemiologically qualified field study. Most of the studies are hospital based or clinical studies which did not include a systematical scanning and did not aim to collect any epidemiological data and transfer information to health authorities. The generalizability of these studies to our community is far from being valid and reliable. On the other hand, a profile which will be created by reviewing the findings of these studies performed in various regions of Turkey will have a contribution to knowing the and ldquo;unique to us and rdquo; features of bipolar disorder and determining cultural risk factors. All this information can constitute a basis for formation and development of public mental health services related with bipolar disorder. In Turkey, the need for epidemiologically significant, polycentric, public sampled studies with broad participation is indispensable. Although our psychiatric epidemiology and clinical studies include necessary scientific basis, they are not powerful enough to evaluate the authentic and progressional relations such as rapid urbanization and immigration. The aim of this review is to evaluate and discuss prominent epidemiological findings, deficiencies and possibile future activities related with studies conducted in Turkey about bipolar disorder.. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(2.000: 199-209

  13. Bipolar bozukluklarda intihar

    OpenAIRE

    SAYIL, Işık

    1997-01-01

    Makalede bipolar bozukluklarda intihar olgusuuygulamadan gelen deneyimler doğrultusundagözden geçirilmiştir. İntihar girişimlerinde ilk yardımtartışılmış ve acil serviste kriz ekibinin çalışmasıanlatılmıştır.

  14. Discrete bipolar universal integrals

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    2014-01-01

    Roč. 252, č. 1 (2014), s. 55-65. ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * universal integral * Choquet integral Subject RIV: BA - General Mathematics Impact factor: 1.986, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0432224.pdf

  15. New High Efficiency LED Lighting Solution

    Institute of Scientific and Technical Information of China (English)

    DING Ke; NIU Ping-juan; FU Xian-song

    2008-01-01

    As the quality of power LED improves and the cost of power LED reduces, semiconductor lighting will replace incandescent and fluorescent lighting gradually, causing another revolution on the lighting history. And its driving solution has been greatly accelerated. Based on the white power LED I-V characteristics and the application ambiance, proposed is a new LED lighting solution, suiting indoor and outdoor illumination. According to the test results, the design is optimized, and the electrical efficiency is 95% and the output current deviation is 13.0%.

  16. YINYANG BIPOLAR LATTICES AND L-SETS FOR BIPOLAR KNOWLEDGE FUSION, VISUALIZATION, AND DECISION

    OpenAIRE

    WEN-RAN ZHANG

    2005-01-01

    YinYang bipolar sets, bipolar lattice, bipolar L-crisp sets, and Bipolar L-fuzzy sets are presented for bipolar information/knowledge fusion, visualization, and decision. First, a bipolar lattice B is defined as a 4-tuple (B, ⊕, &, ⊗) in which every pair of elements has a bipolar lub (blub ⊕), a bipolar glb (bglb &), and a cross-pole glb (cglb ⊗). A bipolar L-set (crisp or fuzzy) B = (B-, B+) in X to a bipolar lattice BL is defined as a bipolar equilibrium function or mapping B : X ⇒ BL. A st...

  17. A PSR single-stage flyback LED driver with simple line regulation and quasi-resonant operation

    International Nuclear Information System (INIS)

    A single-stage flyback driving integrated circuit (IC) for light-emitting diodes (LEDs) is proposed. With an average primary-side current estimation and negative feedback networks, the driver operates in the boundary conduction mode (BCM), while the output current can be derived and regulated precisely. By means of a simple external resistor divider, a compensation voltage is produced on the ISEN pin during the turn-on period of the primary MOSFET to improve the line regulation performance. On the other hand, since the delay time between the time that the secondary diode current reaches zero and the turn-on time of the MOSFET can be automatically adjusted, the MOSFET can always turn on at the valley voltage even if the inductance of the primary winding varies with the output power, resulting in quasi-resonant switching for different primary inductances. The driving IC is fabricated in a Dongbu HiTek's 0.35 μm bipolar-CMOS-DMOS process. An 18 W LED driver is finally built and tested. Results show that the driver has an average efficiency larger than 86%, a power factor larger than 0.97, and works under the universal input voltage (85–265 V) with the LED current variation within ±0.5%. (semiconductor integrated circuits)

  18. Shocked molecular hydrogen in the bipolar outflow NGC 2071

    Science.gov (United States)

    Burton, Michael G.; Geballe, T. R.; Brand, P. W. J. L.

    1989-01-01

    Maps of the emission from the v = 1-0 S(1) line of molecular hydrogen in the bipolar outflow of NGC 2071 are presented. The line emission is shown to peak at six positions distributed irregularly along two lobes which are parallel to, but offset about 20 arcsec from, the lobes of the high-velocity CO-line emission. The energetics and composition of the high-velocity gas support a model in which the driving agent is a bipolar atomic wind which arises from the vicinity of the central IR sources and shocks the surrounding molecular cloud, evacuating a cavity within it.

  19. PV power system using hybrid converter for LED indictor applications

    International Nuclear Information System (INIS)

    Highlights: • This paper presents a LED indictor driving circuit with a PV arrays as its power source. • The perturb-and-observe method is adopted to extract the maximum power of PV arrays. • The proposed circuit structure has a less component counts and higher conversion efficiency. • A prototype of LED indictor driving circuit has been implemented to verify its feasibility. • The proposed hybrid converter is suitable for LED inductor applications. - Abstract: This paper presents a LED indictor driving circuit with a PV arrays as its power source. The LED indictor driving circuit includes battery charger and discharger (LED driving circuit). In this research, buck converter is used as a charger, and forward converter with active clamp circuit is adopted as a discharger to drive the LED indictor. Their circuit structures use switch integration technique to simplify them and to form the proposed hybrid converter, which has a less component counts, lighter weight, smaller size, and higher conversion efficiency. Moreover, the proposed hybrid converter uses a perturb-and-observe method to extract the maximum power from PV arrays. Finally, a prototype of an LED indictor driving circuit with output voltage of 10 V and output power of 20 W has been implemented to verify its feasibility. It is suitable for the LED inductor applications

  20. LED Color Characteristics

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-01-01

    Color quality is an important consideration when evaluating LED-based products for general illumination. This fact sheet reviews the basics regarding light and color and summarizes the most important color issues related to white-light LED systems.

  1. A single-chip two-wavelength switchable strained Si{sub 1-x}Ge {sub x}/Si-quantum-well LED

    Energy Technology Data Exchange (ETDEWEB)

    Yasuhara, Nozomu [Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902 (Japan)]. E-mail: cc47925@mail.ecc.u-tokyo.ac.jp; Fukatsu, S. [Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902 (Japan); PRESTO, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012 (Japan)

    2006-06-05

    Voltage-controlled emission wavelength switching (VCEWS) is demonstrated in a light-emitting diode (LED) containing a strained Si{sub 1-x}Ge {sub x}/Si double quantum well (DQW) in the active region. Impact ionization in a reverse-biased Si and SiGe allows the otherwise evasive bipolar VCEWS in LEDs containing type-II anti-electron QWs. A clear spectral dominance switch was observed upon changing the direction of the driving current where electroluminescence (EL) from the QW on the positive electrode side dominated. In transient EL, a 500 kHz bandwidth was obtained, indicating that the impact ionization controls the generation of the carriers.

  2. LEDs for greenhouse lighting

    OpenAIRE

    Nederhoff, E.M.

    2010-01-01

    Light Emitting Diodes (LED's) are a promising technology for greenhouse lighting with their efficiency to activate plant photosynthesis potentially higher in red LEDs than in HPS lamps. Due to their particular light colour, LEDs can initiate special effects in plants or steer plant processes and plant balance

  3. LEDs for greenhouse lighting

    NARCIS (Netherlands)

    Nederhoff, E.M.

    2010-01-01

    Light Emitting Diodes (LED's) are a promising technology for greenhouse lighting with their efficiency to activate plant photosynthesis potentially higher in red LEDs than in HPS lamps. Due to their particular light colour, LEDs can initiate special effects in plants or steer plant processes and pla

  4. BIPOLAR DISORDER IN ADULTS

    Directory of Open Access Journals (Sweden)

    Yadav Jaya

    2013-06-01

    Full Text Available Bipolar disorder is a chronic illness, which may require life-long treatment. Patients will spend 3-5 times more days in the depressed episode then in the manic phase. Due to this variability in episodes, polypharmacy is used quite frequently in practice, though the evidence to do this remains quite limited. Many positive and negative outcomes can occur from this practice. Bipolar disorder is the 6th leading cause of disability in the developed world among those between the ages 15 and 44 years age groups. Serotonin is one of the neurotransmitter in the brain, and one of that strongly affects the person mood. Clozapine (clozaril, olanzapine (zyperexa, risperidone (Risperdal, and ziprasidone (zeldox and the clozapine may be helpful as mood stabilizer for people who do not respond to lithium and anticonvulsant.

  5. Development and testing of a bipolar lead-acid battery for hybrid electric vehicles

    NARCIS (Netherlands)

    Saakes, M.; Kluiters, E.; Schmal, D.; Mourad, S.; Have, P.T.J.H. ten

    1999-01-01

    An 80 V bipolar lead-acid battery was constructed and tested using hybrid electric vehicle (HEV) drive cycles. Drive cycles with a peak power of 6.7 kW, equal to 1/5 of the total power profile required for the HEV studied, were run successfully. Model calculations showed that the 80 V module constru

  6. Life expectancy in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    OBJECTIVE: Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20 years. These calculations are based on data for individuals at the age of 15 years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later...... onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder. METHODS: Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we...... remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life-years during early and mid-adulthood. CONCLUSIONS: Life expectancy in bipolar disorder is decreased substantially, but less so than previously...

  7. Bipolar Disorder and Cancer

    OpenAIRE

    Sermin Kesebir; Arzu Bayrak

    2012-01-01

    Prevalence studies and studies on causation relations have shown that the relation between psychiatric disorders and chronic physical diseases is neglected. For heterogeneous diseases an increasing number of susceptibility variants are being defined. Alzheimer disease, bipolar disorder, breast and prostate cancer, coronary artery disease, Chron's disease, systemic lupus eritematosus, type 1 and type 2 diabetes mellitus are mentioned together with epigenetic concept. In acrocentric zone of chr...

  8. Treatment of bipolar disorder

    OpenAIRE

    Geddes, John R.; Miklowitz, David J.

    2013-01-01

    We review recent developments in the acute and long-term treatment of bipolar disorder and identify promising future routes to therapeutic innovation. Overall, advances in drug treatment remain quite modest. Antipsychotic drugs are effective in the acute treatment of mania; their efficacy in the treatment of depression is variable with the clearest evidence for quetiapine. Despite their widespread use, considerable uncertainty and controversy remains about the use of antidepressant drugs in t...

  9. Development of Bipolar Plate Stack Type Microbial Fuel Cells

    International Nuclear Information System (INIS)

    Microbial fuel cells (MFC) stacked with bipolar plates have been constructed and their performance was tested. In this design, single fuel cell unit was connected in series by bipolar plates where an anode and a cathode were made in one graphite block. Two types of bipolar plate stacked MFCs were constructed. Both utilized the same glucose oxidation reaction catalyzed by Gram negative bacteria, Proteus vulgaris as a biocatalyst in an anodic compartment, but two different cathodic reactions were employed: One with ferricyanide reduction and the other with oxygen reduction reactions. In both cases, the total voltage was the mathematical sum of individual fuel cells and no degradation in performance was found. Electricity from these MFCs was stored in a supercapacitor to drive external loads such as a motor and electric bulb

  10. Bipolar Disorder in Children and Teens

    Science.gov (United States)

    ... is in crisis. What do I do? Share Bipolar Disorder in Children and Teens Download PDF Download ePub ... brochure will give you more information. What is bipolar disorder? Bipolar disorder is a serious brain illness. It ...

  11. Prophylactic treatment in bipolar disorder

    OpenAIRE

    Eroğlu, Meliha Zengin; Özpoyraz, Nurgül; Tamam, Lut

    2014-01-01

    Objective: The aim of this study was to determine the prophylactic treatment response and its relationship between clinical variables among the bipolar disorder patient group followed up in the Bipolar Disorder Unit of Psychiatry Department of Cukurova University Faculty of Medicine. Methods: One hundred patients, in euthymic period, diagnosed as bipolar disorder, were included in this study. “Affective Disorders Patient Registry Form” developed by our unit, SCID-I, Young Mani Rating Scale...

  12. Mathematical models of bipolar disorder

    OpenAIRE

    Daugherty, D; Roque-Urrea, T; Urrea-Roque, J; DE TROYER, J; Wirkus, S; Porter, M. A.

    2009-01-01

    We use limit cycle oscillators to model bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about 1% of the United States adult population. We consider two non-linear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using ...

  13. The Genetics of Bipolar Disorder

    OpenAIRE

    Jennifer H Barnett; Smoller, Jordan W.

    2009-01-01

    Bipolar disorder is a mood disorder characterized by impairing episodes of mania and depression. Twin studies have established that bipolar disorder is among the most heritable of medical disorders and efforts to identify specific susceptibility genes have intensified over the past two decades. The search for genes influencing bipolar disorder has been complicated by a paucity of animal models, limited understanding of pathogenesis, and the genetic and phenotypic complexity of the syndrome. L...

  14. Mathematical Models of Bipolar Disorder

    OpenAIRE

    Daugherty, Darryl; Roque-Urrea, Tairi; Urrea-Roque, John; Snyder, Jessica; Wirkus, Stephen; Mason A. Porter

    2003-01-01

    We use limit cycle oscillators to model Bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about one percent of the United States adult population. We consider two nonlinear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individual...

  15. Childhood trauma in bipolar disorder

    OpenAIRE

    Watson, S; Gallagher, P.; Dougall, D.; R Porter; Moncrieff, J.; Ferrier, I. N.; Young, A. H.

    2014-01-01

    Objective: There has been little investigation of early trauma in bipolar disorder despite evidence that stress impacts on the course of this illness. We aimed to compare the rates of childhood trauma in adults with bipolar disorder to a healthy control group, and to investigate the impact of childhood trauma on the clinical course of bipolar disorder. Methods: Retrospective assessment of childhood trauma was conducted using the Childhood Trauma Questionnaire (CTQ) in 60 outpatients with bipo...

  16. Scientific attitudes towards bipolar disorders

    OpenAIRE

    Mohammad-Hossein Biglu; Sahar Biglu

    2014-01-01

    Introduction: Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry out day-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, all papers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E) database through 2001-2011; second, papers published by the international journal of Bipolar Disorders indexed in SCI-E d...

  17. Pediatrik Bipolar Bozuklukta Epidemiyoloji

    OpenAIRE

    Caner Mutlu; Neslim Guvendeger Doksat; Ayten Erdogan

    2015-01-01

    Çocuk ve ergenlerde bipolar bozukluk tanısı giderek artış göstermektedir. Çocuk ve ergen popülasyonunda intihar girişiminde bulunanların önemli bir oranının bipolar bozukluğu olanlarda ortaya çıkıyor olması, bu hastalığın tanı ve tedavisini daha da önemli kılmaktadır. Özellikle ergenlik dönemi öncesi örneklemlerde açık tanı ölçütlerinin olmaması ve değerlendirmelerin belirtilere dayanılarak yapılmasından dolayı yanlış biçimde bipolar bozukluk tanısı konduğu ve yaygınlık oranlarının oldu-ğunda...

  18. Bipolar Disorder and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Sermin Kesebir

    2010-04-01

    Full Text Available Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders patients should be considered at high risk for diabetes mellitus. The prevalence of diabetes mellitus in bipolar disorder may be three times greater than in the general population. Comorbidity of diabetes causes a pathophysiological overlapping in the neurobiological webs of bipolar cases. Signal mechanisms of glycocorticoid/insulin and immunoinflammatory effector systems are junction points that point out the pathophysiology between bipolar disorder and general medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3 is a serine/treonine kinase and inhibits the transport of glucose stimulated by insulin. It is affected in diabetes, cancer, inflammation, Alzheimer disease and bipolar disorder. Hypoglycemic effect of lithium occurs via inhibiting glycogen synthetase kinase. When comorbid with diabetes, the other disease -for example bipolar disorder, especially during its acute manic episodes-, causes a serious situation that presents its influences for a lifetime. Choosing pharmacological treatment and treatment adherence are another important interrelated areas. The aim of this article is to discuss and review the etiological, clinical and therapeutic properties of diabetes mellitus and bipolar disorder comorbidity.

  19. [Antipsychotics in bipolar disorders].

    Science.gov (United States)

    Vacheron-Trystram, M-N; Braitman, A; Cheref, S; Auffray, L

    2004-01-01

    This article is a review of the various treatments that are currently available, in particular in France, for the treatment of bipolar disorders. This article specifically addresses the use of novel antipsychotic agents as alternative therapy to a lithium therapy and/or the use of conventional antipsychotics. The prevalence of bipolar disorder over a lifetime is around 1% of the general population. Bipolar disorder consists of alternating depressive and manic episodes. It mainly affects younger subjects, and is often associated with alcohol and drug addictions. There are two main subtypes of bipolar disorder. According to the DSM IV-R, type 1 of bipolar disorder is characterised when at least one manic episode (or a mixed episode) has been diagnosed. Type 2 of bipolar disorder is related to patients enduring recurrent depressive episodes but no manic episode. Type 2 affects women more frequently as opposed to type 1 affecting individuals of both sexes. Manic-depressive disorder (or cyclo-thymic disorder) appears in relation to patients who has never suffered manic episode, mixed episode or severe depressive episode but have undergone numerous periods with some symptoms of depression and hypomanic symptoms over a two-year period during which any asymptomatic periods last no longer than two months. The average age of the person going through a first episode (often a depressive one) is 20 years-old. Untreated bipolar patients may endure more than ten manic or depressive episodes. Finally, in relation to 10 to 20% of patients, the bipolar disorder will turn into a fast cycle form, either spontaneously or as a result of certain medical treatments. Psychiatrists are now able to initiate various treating strategies which are most likely to be effective as a result of the identification of clinical subtypes of the bipolar disorder. Lithium therapy has been effectively and acutely used for patients with pure or elated mania and its prophylaxis. However, lithium medication

  20. LED-roulette: LED's vervangen balletje

    OpenAIRE

    Goossens, P

    2007-01-01

    Iedereen waagt wel eens een gokje, in een loterij of misschien ook in een casino. Wie droomt er immers niet van om op een gemakkelijke manier rijk te worden? Met de hier beschreven LED-roulette valt weliswaar weinig te winnen, maar het is wel een uitstekende manier om het roulettespel thuis te beoefenen op een eerlijke manier. Je kunt er namelijk niet mee valsspelen, de microcontroller die de LED’s aanstuurt is, onomkoopbaar.

  1. LED-valaisimien kuormitustaulukointi

    OpenAIRE

    Reinilä, Toni

    2015-01-01

    Opinnäytetyössä perehdyttiin virran käyttäytymiseen LED-valaisimen käynnistyessä. Työssä syvennyttiin LED-valaisimien teoriaan sekä teholähteiden ominaisuuksiin. Työ tehtiin Winled Oy:n pyynnöstä, koska yrityksellä oli tarve LED-valaisimien kuormitustaulukolle. Opinnäytetyön tavoite oli tuottaa lisää tietoa LED-valaisimista ja niiden ominaisuuksista. LED-valaisimen tiedetään ottavan suuria virtoja käynnistyessään. Työn tarkoitus oli laatia LED-valaisimien käynnistysvirroista kuormitustaulukko...

  2. Led-valaistus liikerakennuksessa

    OpenAIRE

    Heikkilä, Juho

    2014-01-01

    Tässä insinöörityössä tutkittiin led-valaistuksen tuomia mahdollisuuksia liikerakennuksien valaistuksessa. Aihetta pohdittiin suunnittelijan näkökulmasta ja painotus oli liikerakennuksen eri tilojen valaistusmahdollisuuksissa. Liikerakennuksissa on tarvetta yleisvalaistukselle, kohdevalaistukselle, sosiaalitilojen sekä pysäköintipaikkojen valaistukselle. Näille tiloille pyrittiin suunnittelemaan optimaalinen valaistus led-valaisimilla. Led-valaisimet ovat korvaamassa valaisimia kaikilla näill...

  3. Genetics of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Kerner B

    2014-02-01

    Full Text Available Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a “risk” allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are

  4. Scientific attitudes towards bipolar disorders

    Directory of Open Access Journals (Sweden)

    Mohammad-Hossein Biglu

    2014-02-01

    Full Text Available Introduction: Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry out day-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, all papers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E database through 2001-2011; second, papers published by the international journal of Bipolar Disorders indexed in SCI-E during a period of 11 years; and third, all papers distributed by the international journal of Bipolar Disorders indexed in MEDLINE during the period of study. Methods: The SCI-E database was used to extract all papers indexed with the topic of Bipolar Disorders as well as all papers published by The International Journal of Bipolar Disorders. Extraction of data from MEDLINE was restricted to the journals name from setting menu. The Science of Science Tool was used to map the co-authorship network of papers published by The International Journal of Bipolar Disorders through 2009-2011. Results: Analysis of data showed that the majority of publications in the subject area of bipolar disorders indexed in SCI-E were published by The International Journal of Bipolar Disorders. Although journal articles consisted of 59% of the total publication type in SCI-E, 65% of publications distributed by The Journal of Bipolar Disorders were in the form of meetingabstracts. Journal articles consisted of only 23% of the total publications. USA was the leading country regarding sharing data in the field of bipolar disorders followed by England, Canada, and Germany. Conclusion: The editorial policy of The International Journal of Bipolar Disorders has been focused on new themes and new ways of researching in the subject area of bipolar disorder. Regarding the selection of papers for indexing, the SCI-E database selects data more comprehensively than MEDLINE. The number of papers

  5. Tobacco Use in Bipolar Disorder

    Science.gov (United States)

    Thomson, Daniel; Berk, Michael; Dodd, Seetal; Rapado-Castro, Marta; Quirk, Shae E.; Ellegaard, Pernille K.; Berk, Lesley; Dean, Olivia M.

    2015-01-01

    Tobacco use in mental health in general and bipolar disorder in particular remains disproportionally common, despite declining smoking rates in the community. Furthermore, interactions between tobacco use and mental health have been shown, indicating the outcomes for those with mental health disorders are impacted by tobacco use. Factors need to be explored and addressed to improve outcomes for those with these disorders and target specific interventions for people with psychiatric illness to cease tobacco smoking. In the context of bipolar disorder, this review explores; the effects of tobacco smoking on symptoms, quality of life, suicidal behaviour, the biological interactions between tobacco use and bipolar disorder, the interactions between tobacco smoking and psychiatric medications, rates and factors surrounding tobacco smoking cessation in bipolar disorder and suggests potential directions for research and clinical translation. The importance of this review is to bring together the current understanding of tobacco use in bipolar disorder to highlight the need for specific intervention. PMID:25912533

  6. Bipolar Disorder and Childhood Trauma

    Directory of Open Access Journals (Sweden)

    Evrim Erten

    2015-06-01

    Full Text Available Bipolar disorder is a chronic disorder in which irregular course of depressive, mania or mixed episodes or a complete recovery between episodes can be observed. The studies about the effects of traumatic events on bipolar disorder showed that they had significant and long-term effects on the symptoms of the disorder. Psychosocial stress might change the neurobiology of bipolar disorder over time. The studies revealed that the traumatic events could influence not only the onset of the disorder but also the course of the disorder and in these patients the rate of suicide attempt and comorbid substance abuse might increase. Bipolar patients who had childhood trauma had an earlier onset, higher number of episodes and comorbid disorders. In this review, the relationship between childhood trauma and bipolar disorder is reviewed. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2015; 7(2: 157-165

  7. Dansk LED - Museumsbelysning

    DEFF Research Database (Denmark)

    Poulsen, Peter Behrensdorff; Dam-Hansen, Carsten; Thorseth, Anders;

    Projektet har til formål at anvende dansk forskning inden for optik og lys til at realisere innovative energieffektive LED lyssystemer til museumsbranchen.......Projektet har til formål at anvende dansk forskning inden for optik og lys til at realisere innovative energieffektive LED lyssystemer til museumsbranchen....

  8. Bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2008-10-21

    A bipolar pulse forming transmission line module for linear induction accelerators having first, second, third, fourth, and fifth planar conductors which form an interleaved stack with dielectric layers between the conductors. Each conductor has a first end, and a second end adjacent an acceleration axis. The first and second planar conductors are connected to each other at the second ends, the fourth and fifth planar conductors are connected to each other at the second ends, and the first and fifth planar conductors are connected to each other at the first ends via a shorting plate adjacent the first ends. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short a high voltage from the first end of the third planar conductor to the first end of the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  9. Complement and Isomorphism on Bipolar Fuzzy Graphs

    Directory of Open Access Journals (Sweden)

    Ali Asghar Talebi

    2014-12-01

    Full Text Available In this paper, we discuss some properties of the self complement and self weak complement bipolar fuzzy graphs, and get a sufficient condition for a bipolar fuzzy graph to be the self weak complement bipolar fuzzy graph. Also we investigate relations between operations union, join, and complement on bipolar fuzzy graphs.

  10. Complement and Isomorphism on Bipolar Fuzzy Graphs

    OpenAIRE

    Ali Asghar Talebi; Hossein Rashmanlou

    2014-01-01

    In this paper, we discuss some properties of the self complement and self weak complement bipolar fuzzy graphs, and get a sufficient condition for a bipolar fuzzy graph to be the self weak complement bipolar fuzzy graph. Also we investigate relations between operations union, join, and complement on bipolar fuzzy graphs.

  11. LED-kasvivalaisin

    OpenAIRE

    Anttila, Toni

    2008-01-01

    LED-teknologian käyttö kasvihuonevalaistuksessa tulee lisääntymään. LED-valaistuksen etuja ovat mahdollisuudet energian säästöön, kasvatustilan vähentäminen ja mahdollisuudet kontrolloida kasvien kasvua. Tulevaisuudessa erityisvalaistuksen määrä kasvien kasvatuksessa tulee lisääntymään. Tässä työssä suunniteltiin ja rakennettiin LED-kasvivalaisin. Työssä käytiin läpi teoreettinen pohja kasvivalotukselle ja esiteltiin suunnittelun ja rakentamisen eri vaiheet ongelmineen ja erityispiirteine...

  12. Spectroradiometry for LED characterization

    DEFF Research Database (Denmark)

    Dam-Hansen, Carsten

    Radiospectroscopy is the absolute measurement of electromagnetic radiation within a specific wavelength range. For characterization of LED components, light sources and lamps we are interested in absolute measurement of the spectral power distribution, SPD, in the visible and near infrared region....... Using integrating spheres for light collection setups for absolute total spectral flux is realized at the LED Light Lab at DTU Fotonik, Risø Campus. From these, both total radiant and luminous flux is determined and through electrical power measurement also the efficiency is determined. From the SPD...... colorimetric quantities like color coordinates, color temperature and color rendering indices are calculated. The facilities and special issues concerning LED measurements compared to traditional light sources are explained and examples from the “LED lighting quality program”, a project supported by the Danish...

  13. Burden of Illness in Bipolar Depression

    OpenAIRE

    Manning, J. Sloan

    2005-01-01

    Bipolar depression is the underrecognized and unappreciated phase of bipolar disorder. Nevertheless, bipolar depression is responsible for much of the morbidity and mortality associated with the disorder. Depressive symptoms are far more prevalent than hypomanic or manic symptoms in bipolar patients, and they are associated with a heavier burden of illness, including reduced functioning, increased risk of suicidal acts, and high economic costs. Because most patients with bipolar disorder pres...

  14. Prospects for LED lighting.

    Energy Technology Data Exchange (ETDEWEB)

    Tsao, Jeffrey Yeenien; Gee, James Martin; Simmons, Jerry Alvon

    2003-08-01

    Solid-state lighting using light-emitting diodes (LEDs) has the potential to reduce energy consumption for lighting by 50% while revolutionizing the way we illuminate our homes, work places, and public spaces. Nevertheless, substantial technical challenges remain in order for solid-state lighting to significantly displace the well-developed conventional lighting technologies. We review the potential of LED solid-state lighting to meet the long-term cost goals.

  15. RS-232 Led Board

    OpenAIRE

    Tskhvaradze, Vladimir

    2007-01-01

    This article demonstrates how to develop a Microchip PIC16F84 based device that supports RS-232 interface with PC. Circuit (LED Board) design and software development will be discussed. PicBasic Pro Compiler from microEngineering Labs, Inc. is used for PIC programming. Development of LED Board Control Console using C/C++ is also briefly discussed. The project requires basic work experience with Microchip PICs, serial communication and programming.

  16. LED facades in urbarchitecture

    OpenAIRE

    Cekić Nikola; Dačić Miloš; Kostić Aleksandra

    2012-01-01

    Rapid development of electronic technologies at the beginning of this century resulted in intensive changes in urbarchitectonic formation of façade planes and physical structures. Advent of LED lights and LED panels made possible that the physical structures in urban agglomerations worldwide, old or new, have opened a new chapter for strategic urbarchitectonic design and different cultural illumination diversity of houses in space. The user relationship towards activities in physical en...

  17. Surface plasmon enhanced LED

    OpenAIRE

    Vučković, Jelena; Lončar, Marko; Painter, Oskar; Scherer, Axel

    2000-01-01

    Summary form only given. We designed and fabricated an LED based on a thin semiconductor membrane (λ/2) with silver mirrors. A large spontaneous emission enhancement and a high modulation speed are obtainable due to the strong localization of the electromagnetic field in the microcavity. The coupling to surface plasmon modes which are subsequently scattered out by means of a grating is used to improve the extraction efficiency of the LED. The bottom mirror is thick and unpatterned. The top mi...

  18. Asenapine for bipolar disorder

    Directory of Open Access Journals (Sweden)

    Scheidemantel T

    2015-12-01

    Full Text Available Thomas Scheidemantel,1 Irina Korobkova,2 Soham Rej,3,4 Martha Sajatovic1,2 1University Hospitals Case Medical Center, 2Case Western Reserve University School of Medicine, Cleveland, OH, USA; 3Department of Psychiatry, University of Toronto, Toronto, ON, 4Geri PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada Abstract: Asenapine (Saphris® is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of administration. In this review, we examine and summarize the available literature on the safety, efficacy, and tolerability of asenapine in the treatment of bipolar disorder (BD. Data from randomized, double-blind trials comparing asenapine to placebo or olanzapine in the treatment of acute manic or mixed episodes showed asenapine to be an effective monotherapy treatment in clinical settings; asenapine outperformed placebo and showed noninferior performance to olanzapine based on improvement in the Young Mania Rating Scale scores. There are limited data available on the use of asenapine in the treatment of depressive symptoms of BD, or in the maintenance phase of BD. The available data are inconclusive, suggesting the need for more robust data from prospective trials in these clinical domains. The most commonly reported adverse effect associated with use of asenapine is somnolence. However, the somnolence associated with asenapine use did not cause significant rates of discontinuation. While asenapine was associated with weight gain when compared to placebo, it appeared to be modest when compared to other atypical antipsychotics, and its propensity to cause increases in hemoglobin A1c or serum lipid levels appeared to be

  19. Bipolar affective disorder: A review of novel forms of therapy

    OpenAIRE

    Dziwota Ewelina; Drapala Barbara; Gaj Magdalena; Skoczen Nikodem; Olajossy Marcin

    2015-01-01

    Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD). Long-term studies on the mechanisms of action of such medications, as well as on the pathogenetic background of BD, have led to the discovery of effective, albeit unconventional pharmacotherapeutic approaches. These methods have the potential to successfully treat mania and depression, as well as to counter affe...

  20. Electric drives

    CERN Document Server

    Boldea, Ion

    2005-01-01

    ENERGY CONVERSION IN ELECTRIC DRIVESElectric Drives: A DefinitionApplication Range of Electric DrivesEnergy Savings Pay Off RapidlyGlobal Energy Savings Through PEC DrivesMotor/Mechanical Load MatchMotion/Time Profile MatchLoad Dynamics and StabilityMultiquadrant OperationPerformance IndexesProblemsELECTRIC MOTORS FOR DRIVESElectric Drives: A Typical ConfigurationElectric Motors for DrivesDC Brush MotorsConventional AC MotorsPower Electronic Converter Dependent MotorsEnergy Conversion in Electric Motors/GeneratorsPOWER ELECTRONIC CONVERTERS (PECs) FOR DRIVESPower Electronic Switches (PESs)The

  1. Creativity and Bipolar Disorder: Igniting a Dialogue.

    Science.gov (United States)

    Johnson, Sheri L; Moezpoor, Michelle; Murray, Greg; Hole, Rachelle; Barnes, Steven J; Michalak, Erin E

    2016-01-01

    Bipolar disorder (BD) has been related to heightened creativity, yet core questions remain unaddressed about this association. We used qualitative methods to investigate how highly creative individuals with BD understand the role of symptoms and treatment in their creativity, and possible mechanisms underpinning this link. Twenty-two individuals self-identified as highly creative and living with BD took part in focus groups and completed quantitative measures of symptoms, quality of life (QoL), and creativity. Using thematic analysis, five themes emerged: the pros and cons of mania for creativity, benefits of altered thinking, the relationship between creativity and medication, creativity as central to one's identity, and creativity's importance in stigma reduction and treatment. Despite reliance on a small sample who self-identified as having BD, findings shed light on previously mixed results regarding the influence of mania and treatment and suggest new directions for the study of mechanisms driving the creative advantage in BD. PMID:25814521

  2. Light Emitting Diodes (LEDs)

    Science.gov (United States)

    1997-01-01

    A special lighting technology was developed for space-based commercial plant growth research on NASA's Space Shuttle. Surgeons have used this technology to treat brain cancer on Earth, in two successful operations. The treatment technique, called Photodynamic Therapy, requires the surgeon to use tiny, pinhead-size Light Emitting Diodes (LEDs) (a source that releases long wavelengths of light ) to activate light-sensitive, tumor-treating drugs. 'A young woman operated on in May 1999 has fully recovered with no complications and no evidence of the tumor coming back,' said Dr. Harry Whelan, a pediatric neurologist at the Medical Hospital of Wisconsin in Milwaukee. Laser light has been used for this type of surgery in the past, but the LED light illuminates through all nearby tissues, reaching parts of a tumor that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. It can be used for hours at a time while still remaining cool to the touch. The LED light source is compact, about the size of a briefcase, and can be purchased for a fraction of the cost of a laser. The LEDs, developed and managed by NASA's Marshall Space Flight Center, have been used on seven Space Shuttle flights inside the Microgravity Astroculture Facility. This technology has also been successfully used to further commercial research in crop growth.

  3. Light Emitting Diode (LED)

    Science.gov (United States)

    1997-01-01

    A special lighting technology was developed for space-based commercial plant growth research on NASA's Space Shuttle. Surgeons have used this technology to treat brain cancer on Earth, in two successful operations. The treatment technique called photodynamic therapy, requires the surgeon to use tiny pinhead-size Light Emitting Diodes (LEDs) (a source releasing long wavelengths of light) to activate light-sensitive, tumor-treating drugs. Laser light has been used for this type of surgery in the past, but the LED light illuminates through all nearby tissues, reaching parts of a tumor that shorter wavelengths of laser light carnot. The new probe is safer because the longer wavelengths of light are cooler than the shorter wavelengths of laser light, making the LED less likely to injure normal brain tissue near the tumor. It can also be used for hours at a time while still remaining cool to the touch. The LED probe consists of 144 tiny pinhead-size diodes, is 9-inches long, and about one-half-inch in diameter. The small balloon aids in even distribution of the light source. The LED light source is compact, about the size of a briefcase, and can be purchased for a fraction of the cost of a laser. The probe was developed for photodynamic cancer therapy by the Marshall Space Flight Center under a NASA Small Business Innovative Research program grant.

  4. Quetiapine monotherapy for bipolar depression

    OpenAIRE

    THASE, MICHAEL E.

    2008-01-01

    Michael E ThaseDepartments of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; and the University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: Bipolar depression is more common, disabling, and difficult-to-treat than the manic and hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” depressions, antidepressants gener...

  5. Sleep Disturbances in Bipolar Disorder

    OpenAIRE

    Cátia Alves Moreira; Pedro Afonso

    2015-01-01

    Background: Bipolar disorder, characterized by episodes of mania, hypomania and depression is associated with sleep disturbances and circadian rhythm disruption. These changes have significant impact on quality of life and in the disease prognosis. Aims: Review of the main sleep disturbances observed in the bipolar disorder, their clinical impact and the hypothetical pathophysiological mechanisms involved. Methods: We conducted a non-systematic review of the literature in English through rese...

  6. Bipolar spectrum disorders. New perspectives.

    OpenAIRE

    Piver, Andre; Yatham, Lakshmi N.; Raymond W. Lam

    2002-01-01

    OBJECTIVE: To review new perspectives on diagnosis, clinical features, epidemiology, and treatment of bipolar II and related disorders. QUALITY OF EVIDENCE: Articles were identified by searching MEDLINE and ClinPSYCH from January 1994 to August 2001 using the key words bipolar disorder, type II or 2; hypomania; spectrum; or variants. Reference lists from articles were reviewed. Overall, the quality of evidence was not high; we found no randomized controlled trials that specifically addressed ...

  7. Semiconducting polymer LEDs

    Directory of Open Access Journals (Sweden)

    David Braun

    2002-06-01

    The field of semiconducting polymers has its root in the 1977 discovery of the semiconducting properties of polyacetylene1. This breakthrough earned Alan Heeger, Alan MacDiarmid, and Hideki Shirakawa the 2000 Nobel Prize in Chemistry for ‘the discovery and development of conductive polymers’2–5. Other review articles capture how more than two decades of developments in the physical and chemical understanding of these novel materials has led to new device applications as active and passive electronic and optoelectronic devices ranging from diodes and transistors to polymer LEDs, photodiodes, lasers, and solar cells6–11. Much interest in plastic devices derives from the opportunities to use clever control of polymer structure combined with relatively economical polymer synthesis and processing techniques to obtain simultaneous control over electronic, optical, chemical, and mechanical features5. This article focuses on the advances leading to polymer LEDs12–14.

  8. Led-sukellusvalaisin

    OpenAIRE

    Saarelainen, Mikko

    2012-01-01

    Opinnäytetyön aiheena on LED ja sen käyttö sukellusvalaisimissa. Työn tarkoitus oli tutkia miten LED toimii ja miten se soveltuu käytettäväksi sukellusvalaisimessa, sekä syventää omaa tietoutta valosta, mitä se on ja miten sitä mitataan. Työssä käydään läpi LEDin ominaisuuksia ja miten se eroaa muista sukellusvalaisimissa käytetyistä lampuista. Työ on toteutettu tutustumalla LEDiin ja valoon käyttämällä erilaisia lähteitä ja päivittämällä nykyinen sukellusvalaisimeni LED-sukellusvalaisime...

  9. Threat sensitivity in bipolar disorder.

    Science.gov (United States)

    Muhtadie, Luma; Johnson, Sheri L

    2015-02-01

    Life stress is a major predictor of the course of bipolar disorder. Few studies have used laboratory paradigms to examine stress reactivity in bipolar disorder, and none have assessed autonomic reactivity to laboratory stressors. In the present investigation we sought to address this gap in the literature. Participants, 27 diagnosed with bipolar I disorder and 24 controls with no history of mood disorder, were asked to complete a complex working memory task presented as "a test of general intelligence." Self-reported emotions were assessed at baseline and after participants were given task instructions; autonomic physiology was assessed at baseline and continuously during the stressor task. Compared to controls, individuals with bipolar disorder reported greater increases in pretask anxiety from baseline and showed greater cardiovascular threat reactivity during the task. Group differences in cardiovascular threat reactivity were significantly correlated with comorbid anxiety in the bipolar group. Our results suggest that a multimethod approach to assessing stress reactivity-including the use of physiological parameters that differentiate between maladaptive and adaptive profiles of stress responding-can yield valuable information regarding stress sensitivity and its associations with negative affectivity in bipolar disorder. (PsycINFO Database Record (c) 2015 APA, all rights reserved). PMID:25688436

  10. Led-tievalaistus

    OpenAIRE

    Parviainen, Samuli

    2015-01-01

    Opinnäytetyön tavoitteena oli tehdä selvitystyö led-tievalaistuksesta. Työssä perehdytään Tiehallinnon vaatimuksiin tievalaistuksesta ja tievalaistuksesta. Työssä keskitytään tarkemmin led-valaistukseen ja sen hyötyihin. Työssä tarkastellaan myös Euroopan Unionin direktiivejä ja säädöksiä, jotka liittyvät valaistukseen ja energian säätämiseen julkisilla paikolla.

  11. LED-tekniikka elokuvavalaisussa

    OpenAIRE

    Laurila, Mika

    2016-01-01

    Opinnäytetyön tavoitteena oli luoda suomenkielinen katsaus led-tekniikan kehityksen tilanteesta vuonna 2016. Työtä varten haastateltiin viittä suomalaista elokuvavalaisijaa, ja siihen kerättiin kirjallista materiaalia sekä elokuva-alan kirjallisuudesta että internetistä. Työllä haluttiin tuoda esille led-tekniikan tuomia hyötyjä elokuvavalaisussa sekä toisaalta haluttiin paneutua myös ledien aiheuttamiin haasteisiin. Haastatteluiden pohjalta huomattiin ledien teknisen tason nousseen jo s...

  12. LED-valot rakentamisessa

    OpenAIRE

    Jokinen, Matti

    2011-01-01

    Tämä sähkövoimatekniikan opinnäytetyö tehtiin Rejlers Oy:lle.Vuonna 1942 perustettu Suomen Rejlers on osa pohjoismaista Rejlerkoncernen yhtiötä. Yhtiö tarjoaa suunnittelua, konsultointia ja turnkey-toimituksia teollisuuden, energian, rakentamisen ja kiinteistöjen sekä infran toimialoilla Suomessa, Ruotsissa, Virossa ja Norjassa. Opinnäytetyön tavoitteena oli tuoda esille LED-tekniikalla toteutettuja valojen käyttömahdollisuuksia rakentamisessa. Työssä tutustuttiin LED-valojen ominaisuuks...

  13. High Power UV LED Industrial Curing Systems

    Energy Technology Data Exchange (ETDEWEB)

    Karlicek, Robert, F., Jr; Sargent, Robert

    2012-05-14

    UV curing is a green technology that is largely underutilized because UV radiation sources like Hg Lamps are unreliable and difficult to use. High Power UV LEDs are now efficient enough to replace Hg Lamps, and offer significantly improved performance relative to Hg Lamps. In this study, a modular, scalable high power UV LED curing system was designed and tested, performing well in industrial coating evaluations. In order to achieve mechanical form factors similar to commercial Hg Lamp systems, a new patent pending design was employed enabling high irradiance at long working distances. While high power UV LEDs are currently only available at longer UVA wavelengths, rapid progress on UVC LEDs and the development of new formulations designed specifically for use with UV LED sources will converge to drive more rapid adoption of UV curing technology. An assessment of the environmental impact of replacing Hg Lamp systems with UV LED systems was performed. Since UV curing is used in only a small portion of the industrial printing, painting and coating markets, the ease of use of UV LED systems should increase the use of UV curing technology. Even a small penetration of the significant number of industrial applications still using oven curing and drying will lead to significant reductions in energy consumption and reductions in the emission of green house gases and solvent emissions.

  14. Quetiapine monotherapy for bipolar depression

    Directory of Open Access Journals (Sweden)

    Michael E Thase

    2008-03-01

    Full Text Available Michael E ThaseDepartments of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; and the University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: Bipolar depression is more common, disabling, and difficult-to-treat than the manic and hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” depressions, antidepressants generally are not indicated as monotherapies for bipolar depressions and recent studies suggest that - even when used in combination with traditional mood stabilizers – antidepressants may have questionable value for bipolar depression. The current practice is that mood stabilizers are initiated first as monotherapies; however, the antidepressant efficacy of lithium and valproate is modest at best. Within this context the role of atypical antipsychotics is being evaluated. The combination of olanzapine and the antidepressant fluoxetine was the first treatment to receive regulatory approval in the US specifically for bipolar I depression. Quetiapine was the second medication to be approved for this indication, largely as the result of two pivotal trials known by the acronyms of BOLDER (BipOLar DEpRession I and II. Both studies demonstrated that two doses of quetiapine (300 mg and 600 mg given once daily at bedtime were significantly more effective than placebo, with no increased risk of patients switching into mania. Pooling the two studies, quetiapine was effective for both bipolar I and bipolar II depressions and for patients with (and without a history of rapid cycling. The two doses were comparably effective in both studies. Although the efficacy of quetiapine monotherapy has been established, much additional research is necessary. Further studies are needed to more fully investigate dose-response relationships and comparing quetiapine monotherapy to other mood stabilizers

  15. Current-voltage model of LED light sources

    OpenAIRE

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2012-01-01

    Amplitude modulation is rarely used for dimming light-emitting diodes in polychromatic luminaires due to big color shifts caused by varying magnitude of LED driving current and nonlinear relationship between intensity of a diode and driving current. Current-voltage empirical model of light-emitting diode devices, presented in this paper, creates a way to estimate diode's colorimetric properties based on driving current and diode's voltage. The accuracy of the model was tested under direct and...

  16. Latest Developments in LED Standards

    OpenAIRE

    Yurtseven, M. Berker; Onaygil, Sermin

    2015-01-01

    The LED light sources can be stated as the most promising technology for the last decade from the lighting technology point of view. In order to compare LED chips and LED products from different manufacturers and achieve reproducible results, all of the manufacturers shall measure their LEDs or LED based products using same methodology. In this study, it is aimed to explain measurement and performance standards for LED chips and LED based Solid State Lighting products.

  17. Impaired Driving

    Science.gov (United States)

    ... help prevent injuries and deaths from alcohol-impaired driving. The Problem Risk Factors BAC Effects Prevention Additional Resources How big is the problem? In 2014, 9,967 people were killed in alcohol-impaired driving crashes, accounting for nearly one-third (31%) of ...

  18. Distracted Driving

    Science.gov (United States)

    ... 18%) in which someone was injured involved distracted driving. 1 What are the risk factors? Activities Some activities—such as texting—take the driver’s attention away from driving more frequently and for longer periods than other ...

  19. Advances in LEDs for automotive applications

    Science.gov (United States)

    Bhardwaj, Jy; Peddada, Rao; Spinger, Benno

    2016-03-01

    High power LEDs were introduced in automotive headlights in 2006-2007, for example as full LED headlights in the Audi R8 or low beam in Lexus. Since then, LED headlighting has become established in premium and volume automotive segments and beginning to enable new compact form factors such as distributed low beam and new functions such as adaptive driving beam. New generations of highly versatile high power LEDs are emerging to meet these application needs. In this paper, we will detail ongoing advances in LED technology that enable revolutionary styling, performance and adaptive control in automotive headlights. As the standards which govern the necessary lumens on the road are well established, increasing luminance enables not only more design freedom but also headlight cost reduction with space and weight saving through more compact optics. Adaptive headlighting is based on LED pixelation and requires high contrast, high luminance, smaller LEDs with high-packing density for pixelated Matrix Lighting sources. Matrix applications require an extremely tight tolerance on not only the X, Y placement accuracy, but also on the Z height of the LEDs given the precision optics used to image the LEDs onto the road. A new generation of chip scale packaged (CSP) LEDs based on Wafer Level Packaging (WLP) have been developed to meet these needs, offering a form factor less than 20% increase over the LED emitter surface footprint. These miniature LEDs are surface mount devices compatible with automated tools for L2 board direct attach (without the need for an interposer or L1 substrate), meeting the high position accuracy as well as the optical and thermal performance. To illustrate the versatility of the CSP LEDs, we will show the results of, firstly, a reflector-based distributed low beam using multiple individual cavities each with only 20mm height and secondly 3x4 to 3x28 Matrix arrays for adaptive full beam. Also a few key trends in rear lighting and impact on LED light

  20. A review of passive thermal management of LED module

    Institute of Scientific and Technical Information of China (English)

    Ye Huaiyu; Sau Koh; Henk van Zeijl; A. W. J. Gielen; Zhang Guoqi

    2011-01-01

    Recently, the high-brighmess LEDs have begun to be designed for illumination application The increased electrical currents used to drive LEDs lead to thermal issues. Thermal management for LED module is a key design parameter as high operation temperature directly affects their maximum light output, quality, reliability and life time In this review, only passive thermal solutions used on LED module will be studied. Moreover, new thermal interface materials and passive thermal solutions applied on electronic equipments are discussed which have high potential to enhance thc thermal performance of LED Module.

  1. Thermal management for LED applications

    CERN Document Server

    Poppe, András

    2014-01-01

    Thermal Management for LED Applications provides state-of-the-art information on recent developments in thermal management as it relates to LEDs and LED-based systems and their applications. Coverage begins with an overview of the basics of thermal management including thermal design for LEDs, thermal characterization and testing of LEDs, and issues related to failure mechanisms and reliability and performance in harsh environments. Advances and recent developments in thermal management round out the book with discussions on advances in TIMs (thermal interface materials) for LED applications, advances in forced convection cooling of LEDs, and advances in heat sinks for LED assemblies. This book also: Presents a comprehensive overview of the basics of thermal management as it relates to LEDs and LED-based systems Discusses both design and thermal management considerations when manufacturing LEDs and LED-based systems Covers reliability and performance of LEDs in harsh environments Has a hands-on applications a...

  2. Promoting student led education

    OpenAIRE

    Kotecha, Meena

    2011-01-01

    This paper will discuss the encouraging outcomes of a small scale study in which students were encouraged to actively contribute to various aspects of their education. It will share an innovative Student Led Education Initiative that emerged by extending the author’s teaching practice. First year undergraduate students were encouraged to actively contribute to various aspects of their education. The rationale behind this was to inspire students to lead the way in their education. ...

  3. Student-led education

    OpenAIRE

    Kotecha, Meena

    2012-01-01

    The author has co-presented this presentation with her students to discuss the findings of her individual initiative in which she has discussed how she encouraged her undergraduates to actively contribute to various aspects of their education. She has shared an innovative Student Led Education Initiative that emerged by extending her teaching practice. The rationale behind this was to inspire students to lead the way in their education. This was the author's response to The Higher Education W...

  4. Targeting astrocytes in bipolar disorder.

    Science.gov (United States)

    Peng, Liang; Li, Baoman; Verkhratsky, Alexei

    2016-06-01

    Astrocytes are homeostatic cells of the central nervous system, which are critical for development and maintenance of synaptic transmission and hence of synaptically connected neuronal ensembles. Astrocytic densities are reduced in bipolar disorder, and therefore deficient astroglial function may contribute to overall disbalance in neurotransmission and to pathological evolution. Classical anti-bipolar drugs (lithium salts, valproic acid and carbamazepine) affect expression of astroglial genes and modify astroglial signalling and homeostatic cascades. Many effects of both antidepressant and anti-bipolar drugs are exerted through regulation of glutamate homeostasis and glutamatergic transmission, through K(+) buffering, through regulation of calcium-dependent phospholipase A2 (that controls metabolism of arachidonic acid) or through Ca(2+) homeostatic and signalling pathways. Sometimes anti-depressant and anti-bipolar drugs exert opposite effects, and some effects on gene expression in drug treated animals are opposite in neurones vs. astrocytes. Changes in the intracellular pH induced by anti-bipolar drugs affect uptake of myo-inositol and thereby signalling via inositoltrisphosphate (InsP3), this being in accord with one of the main theories of mechanism of action for these drugs. PMID:27015045

  5. Development of Wireless Dimming Control System for LED Stage Light

    OpenAIRE

    Wang Hui Qin; Bai Shi Lei

    2016-01-01

    Compared with the existing wire dimming system of LED stage light which uses the heavy light operating console to adjust the brightness of stage light, a portable wireless dimming control system for LED stage lighting is proposed, fabricated and tested in this paper. The scheme with the core of ATmega16L microcontroller is composed of wireless transmission and reception units, constant current driving circuit of LED, and the control circuit between this two modules. Through the system present...

  6. Imunologia do transtorno bipolar Immunology of bipolar disorder

    OpenAIRE

    Izabela Guimarães Barbosa; Rodrigo Barreto Huguet; Fernando Silva Neves; Moisés Evandro Bauer; Antônio Lúcio Teixeira

    2009-01-01

    OBJETIVO: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. MÉTODOS: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. A...

  7. Preliminary investigations of piezoelectric based LED luminary

    DEFF Research Database (Denmark)

    Nielsen, Dennis; Andersen, Michael A. E.; Meyer, Kaspar Sinding

    2011-01-01

    This paper presents a preliminary study of PT (Piezoelectric Transformer) based SMPS’s (Switch Mode Power Supplies) for LED luminary. The unique properties of PTs (efficiency, power density and EMI) make them highly suitable for this application. Power stage topologies, rectifiers circuits......, modulation schemes, LEDs and LED driving conditions are analyzed. A prototype radial mode PT optimized for ZVS (Zero Voltage Switching) is designed. FEM (Final Element Method) and measurements validates the PT design. A prototype PT based AC/DC converter operating from european mains is proposed. The...... prototype constitutes a light source equivalent to the 40 W incandescent bulb. Experimental results shows, that the prototype are capable of ZVS and dimming (the later trough use of burst mode control)....

  8. Mathematical models of bipolar disorder

    Science.gov (United States)

    Daugherty, Darryl; Roque-Urrea, Tairi; Urrea-Roque, John; Troyer, Jessica; Wirkus, Stephen; Porter, Mason A.

    2009-07-01

    We use limit cycle oscillators to model bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about 1% of the United States adult population. We consider two non-linear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using weakly-coupled, weakly-damped harmonic oscillators. We discuss how the proposed models can be used as a framework for refined models that incorporate additional biological data. We conclude with a discussion of possible generalizations of our work, as there are several biologically-motivated extensions that can be readily incorporated into the series of models presented here.

  9. NAPAJALNIK SVETIL LED

    OpenAIRE

    Grešak, Aleksander

    2013-01-01

    Namen Diplomskega dela je bilo izdelati napajalnik svetil LED. Predstavljene so teoretične podlage delovanja napajalnika, njegova izdelava, ter opravljene določene meritve. Napajalnik deluje na principu stikalnega usmernika, ki izmenično napetost pri visoki frekvenci pretvarja v enosmerno. Uporabili smo pretvornik navzdol, ker je želena izhodna napetost nižja od vhodne. Prednosti stikalnega napajalnika so boljši izkoristek vezja, vezje je manjše in posledično tudi lažje.

  10. LED-valaistus kasvihuoneisiin

    OpenAIRE

    Anderson, Janne

    2010-01-01

    Valo on kasvien tärkein energian ja informaation lähde. Kasvihuoneviljelyssä voidaan keinovalaistuksen avulla pidentää kasvukautta sekä tehostaa tuotantoa. Keinovalaistuksen vaatima sähköenergia on merkittävä kuluerä suomalaisessa kasvihuoneviljelyssä. Tässä työssä selvitettiin LED - valaistuksen soveltuvuutta kasvihuoneviljelyyn sekä ledien tuomia etuja nykyisiin järjestelmiin verrattuna. Ledien avulla on mahdollista päästä merkittäviin säästöihin energiankulutuksessa sekä parantaa sado...

  11. Vilkkuva led-uistin

    OpenAIRE

    Korkala, Mika

    2016-01-01

    Opinnäytetyön tarkoituksena oli kehittää oman idean pohjalta vilkkuva led-uistin ja selvittää idean mahdollinen laillisuus ja patentoitavuus. Opinnäytetyöhön tutkittiin kalastusta, siinä käytettäviä apuvälineitä, kalojen värinäköä sekä Suomen kalastuslakia. Opinnäytetyötä varten tutkittiin myös patentointiprosesseja ja patentointiin liittyviä muita asioita, voimassa olevia ja jo vanhentuneita patentteja aiheeseen liittyen. Tutkimusmateriaalina käytettiin saatavissa olevia tutkimuksia,...

  12. Social support and bipolar disorder

    OpenAIRE

    Paula Mendonça Studart; Severino Bezerra Filho; Ana Beatriz Didier Studart; Amanda Galvão-de Almeida; Ângela Miranda-Scippa

    2015-01-01

    Background Bipolar disorder is a chronic condition that affects the functioning of its carriers in many different ways, even when treated properly. Therefore, it’s also important to identify the psychosocial aspects that could contribute to an improvement of this population’s quality of life.Objective Carry out a literature review on the role of social support in cases of bipolar disorder.Method A research on the following online databases PubMed, Lilacs and SciELO was conducted by using the ...

  13. Bipolar dislocation of the clavicle

    Directory of Open Access Journals (Sweden)

    Wei Jiang

    2012-01-01

    Full Text Available Bipolar dislocation of the clavicle at acromioclavicular and sternoclavicular joint is an uncommon traumatic injury. The conservative treatments adopted in the past is associated with redislocation dysfunction and deformity. A 41 years old lady with bipolar dislocation of right shoulder is treated surgically by open reduction and internal fixation by oblique T-plate at sternoclavicular joint and Kirschner wire stabilization at acromioclavicular joint. The patient showed satisfactory recovery with full range of motion of the right shoulder and normal muscular strength. The case reported in view of rarity and at 2 years followup.

  14. Bipolar dislocation of the clavicle.

    Science.gov (United States)

    Jiang, Wei; Gao, Shu-Guang; Li, Yu-Sheng; Lei, Guang-Hua

    2012-11-01

    Bipolar dislocation of the clavicle at acromioclavicular and sternoclavicular joint is an uncommon traumatic injury. The conservative treatments adopted in the past is associated with redislocation dysfunction and deformity. A 41 years old lady with bipolar dislocation of right shoulder is treated surgically by open reduction and internal fixation by oblique T-plate at sternoclavicular joint and Kirschner wire stabilization at acromioclavicular joint. The patient showed satisfactory recovery with full range of motion of the right shoulder and normal muscular strength. The case reported in view of rarity and at 2 years followup. PMID:23325981

  15. Refractory bipolar disorder and neuroprogression.

    Science.gov (United States)

    da Costa, Sabrina C; Passos, Ives C; Lowri, Caroline; Soares, Jair C; Kapczinski, Flavio

    2016-10-01

    Immune activation and failure of physiologic compensatory mechanisms over time have been implicated in the pathophysiology of illness progression in bipolar disorder. Recent evidence suggests that such changes are important contributors to neuroprogression and may mediate the cross-sensitization of episode recurrence, trauma exposure and substance use. The present review aims to discuss the potential factors related to bipolar disorder refractoriness and neuroprogression. In addition, we will discuss the possible impacts of early therapeutic interventions as well as the alternative approaches in late stages of the disorder. PMID:26368941

  16. Driving offences

    OpenAIRE

    Corbett, C

    2010-01-01

    Copyright @ 2010, Taylor & Francis Group. This material is posted on this site with the permission of the publishers. This chapter on driving offences will largely follow the template of earlier chapters except that owing to their vast number, a limited selection only will be examined based on their high volume, seriousness and public concern. The first section will define what driving offences are, how they developed alongside the emerging car culture, and it will consider the contempora...

  17. Epidemiologia do transtorno bipolar Epidemiology of bipolar disorders

    Directory of Open Access Journals (Sweden)

    Maurício Silva de Lima

    2005-01-01

    Full Text Available A formulação de políticas em saúde mental depende essencialmente de informações a respeito da freqüência e distribuição dos transtornos mentais. Nas últimas duas décadas, pesquisas de base populacional em epidemiologia psiquiátrica têm sido conduzidas, gerando informações detalhadas sobre freqüência, fatores de risco, incapacidade social e utilização de serviços de saúde. Neste artigo, dados sobre a epidemiologia do transtorno bipolar (TB são discutidos, a partir de resultados de recentes pesquisas populacionais: o estudo da Área de Captação Epidemiológica do Instituto Nacional de Saúde Mental dos Estados Unidos (ECA-NIMH, a Pesquisa Nacional de Comorbidade (NCS, a Pesquisa de Morbidade Psiquiátrica na Grã-Bretanha (OPCS, o Estudo Brasileiro Multicêntrico de Morbidade Psiquiátrica e os estudos longitudinais conduzidos por Angst, em Zurique. As estimativas de prevalências de transtorno bipolar são relativamente baixas, independentemente do lugar onde a pesquisa foi conduzida, do tipo de instrumento diagnóstico usado e dos períodos de tempo para os quais a prevalência se aplica. A partir da introdução do conceito de espectro bipolar, ampliando as fronteiras diagnósticas do TB, as estimativas de prevalências encontradas são substancialmente mais altas. Tais estimativas, entretanto, ainda carecem de validação em estudos populacionais. O transtorno afetivo bipolar é igualmente prevalente entre homens e mulheres, sendo mais freqüente entre solteiros ou separados. Indivíduos acometidos têm maiores taxas de desemprego e estão mais sujeitos a utilizarem serviços médicos e serem hospitalizados. O custo e a eficácia dos tratamentos do TB devem ser balanceados com o alto custo individual e social associados à enfermidade.Information about the epidemiology of bipolar disorders is essential for providing a framework for the formulation of effective mental health policy. In the last two decades, population

  18. Emotion-relevant impulsivity predicts sustained anger and aggression after remission in bipolar I disorder.

    Science.gov (United States)

    Johnson, Sheri L; Carver, Charles S

    2016-01-01

    Recent evidence suggests that anger and aggression are of concern even during remission for persons with bipolar I disorder, although there is substantial variability in the degree of anger and aggression across individuals. Little research is available to examine psychological models of anger and aggression for those with remitted bipolar disorder, and that was the goal of this study. Participants were 58 persons diagnosed with bipolar I disorder using the Structured Clinical Interview for DSM-IV, who were followed with monthly symptom severity interviews until they achieved remission, and then assessed using the Aggression-Short Form. We examined traditional predictors of clinical parameters and trauma exposure, and then considered three trait domains that have been shown to be elevated in bipolar disorder and have also been linked to aggression outside of bipolar disorder: emotion-relevant impulsivity, approach motivation, and dominance-related constructs. Emotion-relevant impulsivity was related to anger, hostility, verbal aggression, and physical aggression, even after controlling for clinical variables. Findings extend the importance of emotion-relevant impulsivity to another important clinical outcome and suggest the promise of using psychological models to understand the factors driving aggression and anger problems that persist into remission among persons with bipolar disorder. PMID:26437231

  19. Application of Bipolar Fuzzy Sets in Graph Structures

    OpenAIRE

    Muhammad Akram; Rabia Akmal

    2016-01-01

    A graph structure is a useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we apply the concept of bipolar fuzzy sets to graph structures. We introduce certain notions, including bipolar fuzzy graph structure (BFGS), strong bipolar fuzzy graph structure, bipolar fuzzy Ni-cycle, bipolar fuzzy Ni-tree, bipolar fuzzy Ni-cut vertex, and bipolar fuzzy Ni-bridge, and illustrate these notions by several examp...

  20. Sleep Disturbances in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Cátia Alves Moreira

    2015-11-01

    Full Text Available Background: Bipolar disorder, characterized by episodes of mania, hypomania and depression is associated with sleep disturbances and circadian rhythm disruption. These changes have significant impact on quality of life and in the disease prognosis. Aims: Review of the main sleep disturbances observed in the bipolar disorder, their clinical impact and the hypothetical pathophysiological mechanisms involved. Methods: We conducted a non-systematic review of the literature in English through research in PubMed with the keywords “sleep disturbance”, “bipolar disorder”, “polysomnography”. Results and Conclusions: Complaints about sleep pattern changes may occur during any phase of the disease. These in clude frequent night-time awakenings, poor sleep quality, reduction of the total sleeping time and decreased latency and increased density of REM sleep. The treatment of the sleep disturbances observed in bipolar disorder should be considered a priority, since it prevents symptoms recurrence and facilitate the socio-professional integration, thus providing greater success in patient’s rehabilitation and quality of life.

  1. Corrosion resistant metallic bipolar plate

    Science.gov (United States)

    Brady, Michael P.; Schneibel, Joachim H.; Pint, Bruce A.; Maziasz, Philip J.

    2007-05-01

    A corrosion resistant, electrically conductive component such as a bipolar plate for a PEM fuel cell includes 20 55% Cr, balance base metal such as Ni, Fe, or Co, the component having thereon a substantially external, continuous layer of chromium nitride.

  2. [Cognitive deficits in bipolar disorder].

    Science.gov (United States)

    Sachs, Gabriele; Schaffer, Markus; Winklbaur, Bernadette

    2007-01-01

    Bipolar disorders are often associated with cognitive deficits which have an influence on social functioning and the course of the illness. These deficits have an impact on occupational ability and social integration. To date, specific cognitive domains have been found which characterize bipolar affective disorders. However, there is evidence of stable and lasting cognitive impairment in all phases of the disorder, including the remission phase, in the following domains: sustained attention, memory and executive functions (e.g. cognitive flexibility and problem solving). Although their cognitive deficits are comparable the deficits in patients with schizophrenia are more severe than those with bipolar disorder. Recent brain imaging findings indicate structural and functional abnormalities in the cortical and limbic networks of the brain in patients with bipolar disorder compared to healthy controls. Mood stabilizer and atypical antipsychotics may reduce cognitive deficits in certain domains (e.g. executive functions and word fluency) and may have a positive effect on quality of life and social functioning. PMID:17640495

  3. Social support and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Paula Mendonça Studart

    2015-08-01

    Full Text Available Background Bipolar disorder is a chronic condition that affects the functioning of its carriers in many different ways, even when treated properly. Therefore, it’s also important to identify the psychosocial aspects that could contribute to an improvement of this population’s quality of life.Objective Carry out a literature review on the role of social support in cases of bipolar disorder.Method A research on the following online databases PubMed, Lilacs and SciELO was conducted by using the keywords “social support” or “social networks” and “mood disorders” or “bipolar disorder” or “affective disorder,” with no defined timeline.Results Only 13 studies concerning the topic of social support and BD were found in the search for related articles. Generally speaking, the results show low rates of social support for BD patients.Discussion Despite the growing interest in the overall functioning of patients with bipolar disorder, studies on social support are still rare. Besides, the existing studies on the subject use different methodologies, making it difficult to establish data comparisons.

  4. Designing low cost LED display for the billboard

    Science.gov (United States)

    Hong, Yi-Jian; Uang, Chii-Maw; Wang, Ping-Chieh; Ho, Zu-Sheng

    2011-10-01

    With quickly advance of the computer, microelectronics and photonics technologies, LED display panel becomes a new electronic advertising media. It can be used to show any information whatever characters or graphics. Most LED display panels are built of many Light-Emitting Diodes arranged in a matrix form. The display has many advantages such as low power, low cost, long life and high definition. Because the display panel is asked to show rich color, the LED display panel's driving system becomes very complex. The design methodology of LED display panel's driver becomes more and more important to meet the market requirements. Cost is always the most important issue in public market domain. In this paper, we report a design methodology of LED display panel's driver based on the microprocessor control unit (MCU) system and LED display controller IC, HT1632C, to control three colors, RGB, color LED display panel and the modular panel size is 24*16 in matrix form. The HT1632C is a memory mapping LED display controller, it can be used on many applications, such as digital clock, thermometer, counter, voltmeter or other instrumentation readouts. Three pieces of HT1632C are used to drive a 24*16 RGB LED display panel, in our design case. Each HT163C chip is used to control one of the R, G and B color. As the drive mode is driven in DC mode, the RGB display panel can create and totally of seven colors under the control of MCU. The MCU generates the control signal to drive HT1632C. In this study, the software design methodology is adopted with dynamic display principle. When the scan frequency is 60Hz, LED display panel will get the clear picture and be able to display seven colors.

  5. Color tunable LED spot lighting

    Science.gov (United States)

    Hoelen, C.; Ansems, J.; Deurenberg, P.; van Duijneveldt, W.; Peeters, M.; Steenbruggen, G.; Treurniet, T.; Valster, A.; ter Weeme, J. W.

    2006-08-01

    A new trend in illumination is to use dynamic light to set or dynamically vary the ambience of a room or office. For this we need color tunable spots that can reliably vary over at least a wide range of color temperatures, and preferably also more saturated colors. LEDs are in principle ideally suited for this application thanks to their nature of emitting light in a relatively narrow band. For color tunable spot lighting based on the concept of mixing RGB LED colors, the key results have been presented before. Limitations of these 3-intrinsic-color mixing systems with high color rendering properties are found in a limited operating temperature range due to wavelength shifts, a limited color temperature range, and a low maximum operating temperature due to a strong flux decrease with increasing temperature. To overcome these limitations, a 3-color R pcGB system with phosphor-converted red (R pc) and a 4-color RAGB system have been investigated. With both systems, a CRI of at least 80 can be maintained over the relevant color temperature range of approximately 2700 K to 6500 K. In this paper we compare these concepts on overall system aspects and report on the performance of prototype spot lamps. The main features of the RAGB and R pcGB spot lamp concepts can be summarized as: 1) The RAGB spot overcomes CRI and gamut shortcomings of RGB light sources and gives much freedom in wavelength selection, but suffers from temperature sensitivity and complex controls; 2) The R pcGB spot overcomes shortcomings concerning CRI and thermal dependence of RGB sources and enables relatively simple controls, but needs an improved overall red efficacy. With both color concepts, prototype spot lamps have been built. The amber to red emitting nitridosilicate-based phosphors can be wavelength-tuned for optimal performance, which is found at a peak emission around 610 nm for high color quality systems. This results in a simple and very robust system with good color consistency. For the

  6. Bipolar battery plate

    Science.gov (United States)

    Rowlette, John J. (Inventor)

    1987-01-01

    A liquid-impermeable plate (10) having through-plate conductivity with essentially zero resistance comprises an insulator sheet (12) having a series of spaced perforations (14) each of which contains a metal element (16) sealingly received into the perforation (14). A low-cost plate can readily be manufactured by punching a thermoplastic sheet (40) such as polypropylene with a punching tool (52), filling the apertures with led spheres (63) having a diameter smaller than the holes (50) but larger than the thickness of the sheet, sweeping excess spheres (62) off the sheet with a doctor blade (60) and then pressing a heated platen (74) onto the sheet to swage the spheres into a cylindrical shape and melt the surrounding resin to form a liquid-impermeable collar (4) sealing the metal into the sheet.

  7. Mood Disorders in Family Practice: Beyond Unipolarity to Bipolarity

    OpenAIRE

    Manning, J. Sloan; Ahmed, Saeeduddin; McGuire, Hillary C.; Hay, Donald P.

    2002-01-01

    Primary care physicians increasingly have treated depressive disorders over the last decade. Unrecognized bipolar disorder, sometimes misdiagnosed as unipolar depression, may lead to treatment resistance or nonresponse. We describe differences between unipolar and bipolar disorders, focusing on recognition, diagnosis, and treatment of bipolar spectrum disorders such as bipolar I, bipolar II, antidepressant-induced mania, and cyclothymia. Broadening the understanding of these different disorde...

  8. Nicotine dependence and psychosis in Bipolar disorder and Schizoaffective disorder, Bipolar type.

    Science.gov (United States)

    Estrada, Elena; Hartz, Sarah M; Tran, Jeffrey; Hilty, Donald M; Sklar, Pamela; Smoller, Jordan W; Pato, Michele T; Pato, Carlos N

    2016-06-01

    Patients with Bipolar disorder smoke more than the general population. Smoking negatively impacts mortality and clinical course in Bipolar disorder patients. Prior studies have shown contradictory results regarding the impact of psychosis on smoking behavior in Bipolar disorder. We analyzed a large sample of Bipolar disorder and Schizoaffective disorder, Bipolar Type patients and predicted those with a history of psychosis would be more likely to be nicotine dependent. Data from subjects and controls were collected from the Genomic Psychiatry Cohort (GPC). Subjects were diagnosed with Bipolar disorder without psychosis (N = 610), Bipolar disorder with psychosis (N = 1544). Participants were classified with or without nicotine dependence. Diagnostic groups were compared to controls (N = 10065) using logistic regression. Among smokers (N = 6157), those with Bipolar disorder had an increased risk of nicotine dependence (OR = 2.5; P Bipolar disorder with psychosis were more likely to be dependent than Bipolar disorder patients without psychosis (OR = 1.3; P = 0.03). Schizoaffective disorder, Bipolar Type patients had more risk of nicotine dependence when compared to Bipolar disorder patients with or without psychosis (OR = 1.2; P = 0.02). Bipolar disorder patients experiencing more severity of psychosis have more risk of nicotine dependence. © 2015 Wiley Periodicals, Inc. PMID:26467098

  9. Switched-capacitor isolated LED driver

    Energy Technology Data Exchange (ETDEWEB)

    Sanders, Seth R.; Kline, Mitchell

    2016-03-22

    A switched-capacitor voltage converter which is particularly well-suited for receiving a line voltage from which to drive current through a series of light emitting diodes (LEDs). Input voltage is rectified in a multi-level rectifier network having switched capacitors in an ascending-bank configuration for passing voltages in uniform steps between zero volts up to full received voltage V.sub.DC. A regulator section, operating on V.sub.DC, comprises switched-capacitor stages of H-bridge switching and flying capacitors. A current controlled oscillator drives the states of the switched-capacitor stages and changes its frequency to maintain a constant current to the load. Embodiments are described for isolating the load from the mains, utilizing an LC tank circuit or a multi-primary-winding transformer.

  10. Circadian rhythms in the neuorbiology of bipolar of bipolar disorder

    OpenAIRE

    Timothy, Joseph

    2015-01-01

    Daily rhythms of physiology and behaviour in mammals are orchestrated by a hierarchical network of cellular oscillators. The master pacemaker that defines local and systemic timing across the brain and body are the suprachiasmatic nuclei of the hypothalamus (SCN). Disruption to the timing of sleep and daily behavioural activity can manifest in a range of pathologies including neuropsychiatric disorders. Bipolar disorder (BPD) is once such neurological condition that exhibits profound associat...

  11. [Psychopharmacological treatment of bipolar disease].

    Science.gov (United States)

    Licht, Rasmus W; Vestergaard, Per

    2002-05-01

    This paper gives an update on the psychopharmacological treatment of bipolar disorder. The antimanic efficacy of lithium is well documented. The same applies to valproate, which is also efficacious in mixed mania. Conventional antipsychotics act fast in mania and do not require blood tests, but they have considerable neurological side effects. The newer antipsychotics, olanzapine, risperidone, and ziprasidone, have also been shown to have antimanic efficacy. Clozapine is extremely effective, also when other treatment fails. For the treatment of bipolar depression, lithium, lamotrigine, and antidepressants all seem to work, but antidepressants may sometimes precipitate mania or worsen the course of illness. For prophylaxis, lithium is still to be considered the first drug of choice. However, for several reasons, for instance treatment failure or side effects, long-term treatment with antiepileptics may often be necessary. Among the antiepileptics, carbamazepine, valproate, and lamotrigine are the best studied. PMID:12025705

  12. Unsplit bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2011-05-24

    A bipolar pulse forming transmission line module and system for linear induction accelerators having first, second, third, and fourth planar conductors which form a sequentially arranged interleaved stack having opposing first and second ends, with dielectric layers between the conductors. The first and second planar conductors are connected to each other at the first end, and the first and fourth planar conductors are connected to each other at the second end via a shorting plate. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short at the first end a high voltage from the third planar conductor to the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  13. Prepubertal bipolar disorder: available pharmacological treatment options.

    Science.gov (United States)

    Masi, Gabriele

    2005-04-01

    Awareness of bipolar spectrum disorders in children is rapidly increasing, with a more precise definition of their clinical subtypes and early signs. Paediatric bipolar disorder can lead to an important impairment in scholastic, familial and social functioning, and to a higher risk for substance abuse and suicide. In the context of a multimodal approach, the core treatment of early-onset bipolar disorder is pharmacological. This review focuses on the empirical evidence for pharmacotherapy in paediatric bipolar disorder. Mood stabilizers, including lithium, and older and newer anticonvulsivants will be considered, in mono- or polypharmacy. Atypical antipsychotics will be considered in more severe and/or treatment-resistant manic or mixed episodes. Finally, the prophylaxis of intercritical phases and the management of specific challenging conditions, such as bipolar depression and attention deficit hyperactivity disorder, with bipolar comorbidity, will be reviewed. PMID:15934881

  14. Neurocognitive function in bipolar disorder: a comparison between bipolar I and II disorder and matched controls

    OpenAIRE

    Pålsson, Erik; Figueras, Clara; Johansson, Anette GM; Ekman, Carl-Johan; Hultman, Björn; Östlind, Josefin; Landén, Mikael

    2013-01-01

    Background Cognitive deficits have been documented in patients with bipolar disorder. Further, it has been suggested that the degree and type of cognitive impairment differ between bipolar I and bipolar II disorder, but data is conflicting and remains inconclusive. This study aimed to clarify the suggested differences in cognitive impairment between patients with bipolar I and II disorder in a relatively large, clinically stable sample while controlling for potential confounders. Methods 67 p...

  15. Bipolar disorder: staging and neuroprogression

    OpenAIRE

    Rodrigues, Aline André; Rosa, Adriana R.; Kunz, Maurício; Ascoli, Bruna; Kapczinski, Flávio

    2014-01-01

    In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the fact that different interventions may suit different stages of the disorder, and that better outcomes...

  16. Major Ups and Downs: Bipolar Disorder Brings Extreme Mood Swings

    Science.gov (United States)

    ... our exit disclaimer . Subscribe Major Ups and Downs Bipolar Disorder Brings Extreme Mood Swings Most people feel happy ... Strike Out Stroke Wise Choices Links Dealing with Bipolar Disorder If you have bipolar disorder, get treatment and ...

  17. Cognitive Behavioral Therapy in Bipolar Disorder

    OpenAIRE

    Zeynep Mackali; Ahmet Tosun

    2011-01-01

    Bipolar disorder is an early-onset, chronic disorder. It impairs occupational, social, and family functioning, which makes learning to adapt living with the disorder and its treatment critically important. Therefore, it has now become common knowledge that psychosocial interventions are also necessary in the treatment of bipolar disorder adjunctive to pharmacotherapy. Thus, whichever psychosocial interventions are more effective in bipolar disorder is a crucial research question. In this arti...

  18. Adolescent Bipolar Disorder: A Clinical Vignette

    OpenAIRE

    Rodgers, Melissa J.; Zylstra, Robert G.; McKay, Julia B.; Solomon, A. Lee; Choby, Beth A.

    2010-01-01

    Adolescence is a vulnerable developmental phase marked by physical, psychological, and social changes that rapidly expose young people to a wide range of new stressors. When differentiating between bipolar disorder and teenage “acting out,” a careful history is important. Adolescent bipolar disorder is a psychiatric illness characterized by fluctuating episodes of mood elevation and depression that is frequently neither recognized nor formally diagnosed. Adolescents with bipolar disorder ofte...

  19. Risperidone in the treatment of bipolar mania

    OpenAIRE

    Sajatovic, Martha; Subramoniam, Madhusoodanan; Fuller, Matthew A

    2006-01-01

    Atypical antipsychotic medications have assumed growing importance for the treatment of bipolar disorder, an illness that affects approximately 1.2%–3.7% of the general population in a given year. Current practice guidelines for the treatment of bipolar mania support the use of atypical antipsychotic medications as monotherapy or as a component of polytherapy, and in clinical settings the use of atypical antipsychotics to treat bipolar disorder is widespread. Risperidone is an atypical antips...

  20. Biological rhythm disturbance in remitted bipolar patients

    OpenAIRE

    Rosa, Adriane R; Comes, Mercè; Torrent, Carla; Solè, Brisa; Reinares, Maria; Pachiarotti, Isabella; Salamero, Manel; Kapczinski, Flávio; Colom, Francesc; Vieta, Eduard

    2013-01-01

    Background Biological rhythm disturbance is common in bipolar patients and seems to affect the course and prognosis of the illness negatively. The main aim of the current study was to assess biological rhythms in remitted bipolar patients. We also assessed whether there was an association between clinical variables or functioning and biological rhythms in remitted bipolar participants. Methods The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) was used to assess biologi...

  1. Bipolar Experiences and Self-Identity

    OpenAIRE

    Bedford, Rosie

    2012-01-01

    Background: Bipolar II disorder has a prevalence rate of approximately 0.4% in adults and 1.5% in adolescents, with the onset typically around 18 years old (Merikangas & Lamers, 2012). As the age of onset is during adolescent years the impact on identity is of special interest. Although the profound impact bipolar has on an individual’s sense of self has surfaced as a predominant theme in the bipolar literature, there remains a dearth of research directly addressing this impact. ...

  2. Pharmaceutical treatment of acute bipolar depression

    OpenAIRE

    Fountoulakis, Konstantinos N

    2010-01-01

    The treatment of bipolar depression is one of the most challenging fields in contemporary psychiatry. The best data concern the antipsychotics quetiapine and the olanzapine-fluoxetine combination. However, the usefulness of antidepressants in bipolar depression remains controversial; positive data are available for fluoxetine but negative results have been published for paroxetine. Accumulated knowledge so far suggests that bipolar patients need continuous administration of an antimanic agent...

  3. Distinctions between bipolar and unipolar depression

    OpenAIRE

    Cuellar, Amy K.; Johnson, Sheri L.; Winters, Ray

    2005-01-01

    This is a review of the studies comparing unipolar and bipolar depression, with focus on the course, symptomatology, neurobiology, and psychosocial literatures. These are reviewed with one question in mind: does the evidence support diagnosing bipolar and unipolar depressions as the same disorder or different? The current nomenclature of bipolar and unipolar disorders has resulted in research that compares these disorders as a whole, without considering depression separately from mania within...

  4. The common bipolar phenotype in young people

    OpenAIRE

    Rock, Philippa L; Chandler, Rebecca A.; Harmer, Catherine J.; Rogers, Robert D.; Goodwin, Guy M.

    2013-01-01

    Background Mood elevation is common in adolescents and young adults. The aim of this study was to investigate the prevalence of a bipolar diagnosis and co-morbidity in individuals identified by online screening for experience of (hypo)manic symptoms in order to better define the common bipolar phenotype in young people. Methods Survey data regarding experience of (hypo)manic symptoms and occurrence of co-morbidities were analysed for 106 students satisfying criteria for probable bipolar syndr...

  5. AC drives for industrial plants. Plant kudoyo AC drive sochi

    Energy Technology Data Exchange (ETDEWEB)

    Miyazaki, M.; Shibata, M.; Yamada, S. (Toshiba Corp., Tokyo (Japan))

    1992-08-01

    Features and product series of AC drives for industrial plants were outlined. Configurations and features of various types of AC drives were briefly discussed which are put into market to meet various requirements for industrial plants and wide ranges of output voltage and capacity. The following product series were outlined; the power bipolar transistor inverter for 3.5-600 kVA in output capacity, IGBT inverter for AC 400 V in output voltage and 1,000 kVA or less, GTO inverter for AC 600 V and 700-2,000 kVA, and cycloconverter for AC 1,000-3,000 V and 1,000 kW-20 MW. The following subjects were outlined as current technical trends of AC drives for industrial plants; increasing in capacity of voltage-source PWM inverters, downsizing of converters through highly efficient cooling and highly dense mounting, spreading of sensorless vector controls, and development of high-voltage large-capacity PWM inverters. 6 figs., 2 tabs.

  6. Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression from Bipolar Disorder Not Otherwise Specified

    Science.gov (United States)

    Axelson, David A.; Birmaher, Boris; Strober, Michael A.; Goldstein, Benjamin I.; Ha, Wonho; Gill, Mary Kay; Goldstein, Tina R.; Yen, Shirley; Hower, Heather; Hunt, Jeffrey I.; Liao, Fangzi; Iyengar, Satish; Dickstein, Daniel; Kim, Eunice; Ryan, Neal D.; Frankel, Erica; Keller, Martin B.

    2011-01-01

    Objective: To determine the rate of diagnostic conversion from an operationalized diagnosis of bipolar disorder not otherwise specified (BP-NOS) to bipolar I disorder (BP-I) or bipolar II disorder (BP-II) in youth over prospective follow-up and to identify factors associated with conversion. Method: Subjects were 140 children and adolescents…

  7. Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity

    Directory of Open Access Journals (Sweden)

    Necla Keskin

    2014-08-01

    Full Text Available The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients. Some genetic variants, neurotransmitters especially serotonergic systems and second-messenger systems are thought to be responsible for its etiology. Bipolar disorder alters the clinical aspects of obsessive compulsive disorder and is associated with poorer outcome. The determination of comorbidity between bipolar disorder and obsessive compulsive disorder is quite important for appropriate clinical management and treatment. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(4.000: 429-437

  8. Variable frequency drives : energy efficiency guide

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-01

    This paper presented a guide on variable frequency drive (VFD) technology that was developed to provide a better understanding of VFDs and to facilitate their selection, application, and operation. The guide refers to drives as electronic VFDs. It does not cover variable speed drives (VSDs) that have mechanical or hydraulic controls. The main application for the guide is for off-the-shelf, low voltage VFDs used in combination with commercially available alternating current (ac), polyphase, induction motors in the factional to 500 horsepower range that are 600 V or less and have insulated gate bipolar transistors (IGBT) with pulse width modulation. The guide does not address engineered products for special and large motor applications.

  9. Driving things

    DEFF Research Database (Denmark)

    Nevile, Maurice Richard

    2015-01-01

    I explore how participants organise involvement with objects brought into the car, relative to the demands of driving and social activity. Objects in cars commonly include phones or other technologies, food, body care products, texts, clothing, bags and carry items, toys, and even animals....... pp.155 ((http://www.infrastructure.gov.au/roads/safety/publications/2010/pdf/rsgr_2010001.pdf)) Nevile, M., Haddington, P., Heinemann, T., Rauniomaa, M. (Eds.) Interacting with objects: Language, materiality, and social activity. Amsterdam/Philadelphia: John Benjamins. Redshaw, S. (2008). In the...

  10. Poorer sustained attention in bipolar I than bipolar II disorder

    Directory of Open Access Journals (Sweden)

    Chen Shih-Heng

    2010-02-01

    Full Text Available Abstract Background Nearly all information processing during cognitive processing takes place during periods of sustained attention. Sustained attention deficit is among the most commonly reported impairments in bipolar disorder (BP. The majority of previous studies have only focused on bipolar I disorder (BP I, owing to underdiagnosis or misdiagnosis of bipolar II disorder (BP II. With the refinement of the bipolar spectrum paradigm, the goal of this study was to compare the sustained attention of interepisode patients with BP I to those with BP II. Methods In all, 51 interepisode BP patients (22 with BP I and 29 with BP II and 20 healthy controls participated in this study. The severity of psychiatric symptoms was assessed by the 17-item Hamilton Depression Rating Scale and the Young Mania Rating Scale. All participants undertook Conners' Continuous Performance Test II (CPT-II to evaluate sustained attention. Results After controlling for the severity of symptoms, age and years of education, BP I patients had a significantly longer reaction times (F(2,68 = 7.648, P = 0.001, worse detectability (d' values (F(2,68 = 6.313, P = 0.003 and more commission errors (F(2,68 = 6.182, P = 0.004 than BP II patients and healthy controls. BP II patients and controls scored significantly higher than BP I patients for d' (F = 6.313, P = 0.003. No significant difference was found among the three groups in omission errors and no significant correlations were observed between CPT-II performance and clinical characteristics in the three groups. Conclusions These findings suggested that impairments in sustained attention might be more representative of BP I than BP II after controlling for the severity of symptoms, age, years of education and reaction time on the attentional test. A longitudinal follow-up study design with a larger sample size might be needed to provide more information on chronological sustained attention deficit in BP patients, and to illustrate

  11. Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

    OpenAIRE

    Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

    2011-01-01

    Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS)...

  12. Development of high-performance solar LED lighting system

    International Nuclear Information System (INIS)

    The present study developed a high-performance charge/discharge controller for stand-alone solar LED lighting system by incorporating an nMPPO system design, a PWM battery charge control, and a PWM battery discharge control to directly drive the LED. The MPPT controller can then be removed from the stand-alone solar system and the charged capacity of the battery increases 9.7%. For LED driven by PWM current directly from battery, a reliability test for the light decay of LED lamps was performed continuously for 13,200 h. It has shown that the light decay of PWM-driven LED is the same as that of constant-current driven LED. The switching energy loss of the MOSFET in the PWM battery discharge control is less than 1%. Three solar-powered LED lighting systems (18 W, 100 W and 150 W LED) were designed and built. The long-term outdoor field test results have shown that the system performance is satisfactory with the control system developed in the present study. The loss of load probability for the 18 W solar LED system is 14.1% in winter and zero in summer. For the 100 W solar LED system, the loss of load probability is 3.6% in spring.

  13. Development of high-performance solar LED lighting system

    KAUST Repository

    Huang, B.J.

    2010-08-01

    The present study developed a high-performance charge/discharge controller for stand-alone solar LED lighting system by incorporating an nMPPO system design, a PWM battery charge control, and a PWM battery discharge control to directly drive the LED. The MPPT controller can then be removed from the stand-alone solar system and the charged capacity of the battery increases 9.7%. For LED driven by PWM current directly from battery, a reliability test for the light decay of LED lamps was performed continuously for 13,200 h. It has shown that the light decay of PWM-driven LED is the same as that of constant-current driven LED. The switching energy loss of the MOSFET in the PWM battery discharge control is less than 1%. Three solar-powered LED lighting systems (18 W, 100 W and 150 W LED) were designed and built. The long-term outdoor field test results have shown that the system performance is satisfactory with the control system developed in the present study. The loss of load probability for the 18 W solar LED system is 14.1% in winter and zero in summer. For the 100 W solar LED system, the loss of load probability is 3.6% in spring. © 2009 Elsevier Ltd. All rights reserved.

  14. To LED or not to LED up a store

    OpenAIRE

    Quartier, Katelijn

    2013-01-01

    This presentation offers a wide talk about LED's and retail lighting. Questions like 'what might be its benefits regarding store experience', 'how do consumers experience LED-lit stores', 'is the use of coloured lighting in stores just a hype or is it a new condition' will be answered. Good and bad examples are used to illustrate the answers.

  15. Nobel Prize for blue LEDs

    Science.gov (United States)

    Kraftmakher, Yaakov

    2015-05-01

    A brief review of lighting technologies is presented. Unavoidable restrictions for incandescent light bulbs caused by the Planck distribution and properties of the human eye are illustrated. The efficiency and luminous efficacy of thermal radiation are calculated for various temperatures; the results clearly show the limitations for thermal radiators. The only way to overcome these limitations is using non-thermal radiators, such as fluorescent lamps and light-emitting diodes (LEDs). Unique advantages of LEDs undoubtedly made a revolution in this field. A crucial element of this progress is the blue LEDs (Nobel Prize 2014). Some experiments with a blue and a green LED are described: (i) the luminescence triggered in a green-yellow phosphor inside a white LED by the blue LED; (ii) radiant spectra and ‘efficiency droop’ in the LEDs; (iii) modulation of the blue LED up to 4 MHz; and (iv) the h/e ratio from the turn-on voltage of the green LED. The experiments are suitable for undergraduate laboratories and usable as classroom demonstrations.

  16. Comparison of different LED Packages

    Science.gov (United States)

    Dieker, Henning; Miesner, Christian; Püttjer, Dirk; Bachl, Bernhard

    2007-09-01

    In this paper different technologies for LED packaging are compared, focusing on Chip on Board (COB) and SMD technology. The package technology which is used depends on the LED application. A critical fact in LED technology is the thermal management, especially for high brightness LED applications because the thermal management is important for reliability, lifetime and electrooptical performance of the LED module. To design certain and long life LED applications knowledge of the heat flow from LEDs to the complete application is required. High sophisticated FEM simulations are indispensable for modern development of high power LED applications. We compare simulations of various substrate materials and packaging technologies simulated using FLOTHERM software. Thereby different substrates such as standard FR4, ceramic and metal core printed circuit boards are considered. For the verification of the simulated results and the testing of manufactured modules, advanced measurement tools are required. We show different ways to experimentally characterize the thermal behavior of LED modules. The thermal path is determined by the transient thermal analysis using the MicReD T3Ster analyzer. Afterwards it will be compared to the conventional method using thermocouples. The heat distribution over the module is investigated by an IR-Camera. We demonstrate and compare simulation and measurement results of Chip-on-Board (COB) and Sub-Mounted Devices (SMD) technology. The results reveal that for different applications certain packages are ideal.

  17. Next Generation Bipolar Plates for Automotive PEM Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Adrianowycz, Orest; Norley, Julian; Stuart, David J; Flaherty, David; Wayne, Ryan; ; Williams, Warren; Tietze, Roger; Nguyen, Yen-Loan H; Zawodzinski, Tom; Pietrasz, Patrick

    2010-04-15

    The results of a successful U.S. Department of Energy (DoE) funded two-year $2.9 MM program lead by GrafTech International Inc. (GrafTech) are reported and summarized. The program goal was to develop the next generation of high temperature proton exchange membrane (PEM) fuel cell bipolar plates for use in transportation fuel cell applications operating at temperatures up to 120 °C. The bipolar plate composite developed during the program is based on GrafTech’s GRAFCELL resin impregnated flexible graphite technology and makes use of a high temperature Huntsman Advanced Materials resin system which extends the upper use temperature of the composite to the DoE target. High temperature performance of the new composite is achieved with the added benefit of improvements in strength, modulus, and dimensional stability over the incumbent resin systems. Other physical properties, including thermal and electrical conductivity of the new composite are identical to or not adversely affected by the new resin system. Using the new bipolar plate composite system, machined plates were fabricated and tested in high temperature single-cell fuel cells operating at 120 °C for over 1100 hours by Case Western Reserve University. Final verification of performance was done on embossed full-size plates which were fabricated and glued into bipolar plates by GrafTech. Stack testing was done on a 10-cell full-sized stack under a simulated drive cycle protocol by Ballard Power Systems. Freeze-thaw performance was conducted by Ballard on a separate 5-cell stack and shown to be within specification. A third stack was assembled and shipped to Argonne National Laboratory for independent performance verification. Manufacturing cost estimate for the production of the new bipolar plate composite at current and high volume production scenarios was performed by Directed Technologies Inc. (DTI). The production cost estimates were consistent with previous DoE cost estimates performed by DTI for the

  18. High current and voltage effects in heterojunction bipolar transistor collectors

    International Nuclear Information System (INIS)

    The influence of temperature on speed and power applications is important in heterojunction bipolar transistors with the need for high current drive capability, high cutoff frequency and high voltage handling capability. At high current density, the onset of the Kirk effect is often the main power constraint in the bipolar transistor. An analytical model that accurately describes the physics behind the parasitic electron barrier formation in double heterojunction bipolar transistors in the Si/SiGe, GalnP/GaAs and InP/GaAsSb materials systems at the onset of the Kirk effect is presented. A new lateral current spreading effect due to the electron barrier dependence on collector current density is also discussed. The electron saturation velocity in Ga0.52In0.48P has also been measured as a function of temperature, utilising the Kirk effect in double heterojunction bipolar transistors. An AIGaAs base was used to eliminate the conduction band spike and measurements were carefully performed using pulse biasing to minimise device self-heating. Voltage drops across the base and collector series resistances were also taken into account. The measured room temperature saturation velocity of 5.0 x 106 cm/s decreased rapidly to 2.9 x 106 cm/s at 200 deg C. These results are particularly important for the prediction of frequency performance of Ga0.52In0.48P/(Al)GaAs/Ga0.52In0.48P DHBTs. Avalanche multiplication and hence impact ionisation coefficients for In0.53Ga0.47As have been determined from photomultiplication measurements over the temperature range of 20 - 400 K for a series of p-i-n/n-i-p diodes. Negative temperature dependence is observed in both the electron and hole multiplication of In0.53Ga0.47As at electric fields over 200 kV/cm, contrary to the temperature dependence of collector multiplication previously observed in InP/In0.53Ga0.47As heterojunction bipolar transistors. The results also showed that the breakdown voltage for In0.53Ga0.47As is comparable to GaAs at

  19. Developmental staging models in bipolar disorder

    OpenAIRE

    Passos, Ives C; Jansen, Karen; Kapczinski, Flavio

    2015-01-01

    The previous contribution of Duffy and colleagues suggests that a chain of behavioral events starting during childhood precedes the development of full-blown bipolar disorder. In this vein, the recent contribution of Keown-Stoneman and colleagues brings a new perspective to the study of prodromal symptoms of bipolar disorder.

  20. Modeling "Soft" Errors in Bipolar Integrated Circuits

    Science.gov (United States)

    Zoutendyk, J.; Benumof, R.; Vonroos, O.

    1985-01-01

    Mathematical models represent single-event upset in bipolar memory chips. Physics of single-event upset in integrated circuits discussed in theoretical paper. Pair of companion reports present mathematical models to predict critical charges for producing single-event upset in bipolar randomaccess memory (RAM) chips.

  1. Bipolar Disorder and Cognitive Therapy: A Commentary

    Science.gov (United States)

    Riskind, John H.

    2005-01-01

    This article comments on the three articles (Leahy, 2005; Newman, 2005; and Reilly-Harrington & Knauz, 2005) that deal with the applications of cognitive therapy to treatment of bipolar disorder. They focus on the uses of cognitive therapy in treating three important facets of the special problems of bipolar patients: rapid cycling, severe…

  2. Bipolar states of electrons in clusters

    International Nuclear Information System (INIS)

    Conditions are found under which the production of a bipolar state in a cluster consisting of polar molecules is possible. In (H2O)n cluster the bipolar state is possible under n ≥ 630, and in (NH3)n one - under n ≥ 2015. 4 refs

  3. Swimming in Deep Water: Childhood Bipolar Disorder

    Science.gov (United States)

    Senokossoff, Gwyn W.; Stoddard, Kim

    2009-01-01

    The authors focused on one parent's struggles in finding a diagnosis and intervention for a child who had bipolar disorder. The authors explain the process of identification, diagnosis, and intervention of a child who had bipolar disorder. In addition to the personal story, the authors provide information on the disorder and outline strategies…

  4. Bipolar disorder diagnosis: challenges and future directions.

    Science.gov (United States)

    Phillips, Mary L; Kupfer, David J

    2013-05-11

    Bipolar disorder refers to a group of affective disorders, which together are characterised by depressive and manic or hypomanic episodes. These disorders include: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and hypomanic episodes); cyclothymic disorder (hypomanic and depressive symptoms that do not meet criteria for depressive episodes); and bipolar disorder not otherwise specified (depressive and hypomanic-like symptoms that do not meet the diagnostic criteria for any of the aforementioned disorders). Bipolar disorder type II is especially difficult to diagnose accurately because of the difficulty in differentiation of this disorder from recurrent unipolar depression (recurrent depressive episodes) in depressed patients. The identification of objective biomarkers that represent pathophysiologic processes that differ between bipolar disorder and unipolar depression can both inform bipolar disorder diagnosis and provide biological targets for the development of new and personalised treatments. Neuroimaging studies could help the identification of biomarkers that differentiate bipolar disorder from unipolar depression, but the problem in detection of a clear boundary between these disorders suggests that they might be better represented as a continuum of affective disorders. Innovative combinations of neuroimaging and pattern recognition approaches can identify individual patterns of neural structure and function that accurately ascertain where a patient might lie on a behavioural scale. Ultimately, an integrative approach, with several biological measurements using different scales, could yield patterns of biomarkers (biosignatures) to help identify biological targets for personalised and new treatments for all affective disorders. PMID:23663952

  5. Thomson semiconductors bipolar IC strategy to 1986

    Science.gov (United States)

    Dellamussia, J. P.

    1984-04-01

    The strategy to develop and market bipolar integrated circuits through 1986 by thomson semiconductors is discussed. Current technology and future research on prototype microprocessors using bipolar integrated circuits is evaluated. The physical properties of the circuits such as heat dissipation, energy consumption rates and response times are studied.

  6. Bipolar Disorder in School-Age Children

    Science.gov (United States)

    Olson, Patricia M.; Pacheco, Mary Rae

    2005-01-01

    This article examines the individual components of bipolar disorder in children and the behaviors that can escalate as a result of misdiagnosis and treatment. The brain/behavior relationship in bipolar disorders can be affected by genetics, developmental failure, or environmental influences, which can cause an onset of dramatic mood swings and…

  7. White matter microstructure alterations in bipolar disorder

    OpenAIRE

    Bellani, M; Perlini, C.; Ferro, A.; Cerruti, S.; G. Rambaldelli; Isola, M.; CERINI, R.; N. Dusi; N. Andreone; Balestrieri, M.; R. Pozzi Mucelli; Tansella, M; Brambilla, P

    2012-01-01

    Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls.

  8. Management of Bipolar II Disorder

    OpenAIRE

    Michael M.C Wong

    2011-01-01

    Bipolar II disorder (BP II) disorder was recognized as a distinct subtype in the DSM-IV classification. DSM-IV criteria for BP II require the presence or history of one or more major depressive episode, plus at least one hypomanic episode, which, by definition, must last for at least 4 days. Various studies found distinct patterns of symptoms and familial inheritance for BP II disorder. BP II is commonly underdiagnosed or misdiagnosed. Making an early and accurate diagnosis of BP II is utmost...

  9. Bipolar Ag-Zn battery

    Science.gov (United States)

    Giltner, L. John

    1994-02-01

    The silver-zinc (AgZn) battery system has been unique in its ability to safely satisfy high power demand applications with low mass and volume. However, a new generation of defense, aerospace, and commercial applications will impose even higher power demands. These new power demands can be satisfied by the development of a bipolar battery design. In this configuration the power consuming, interelectrode current conductors are eliminated while the current is then conducted via the large cross-section electrode substrate. Negative and positive active materials are applied to opposite sides of a solid silver foil substrate. In addition to reducing the weight and volume required for a specified power level, the output voltage performance is also improved as follows. Reduced weight through: elimination of the plastic cell container; elimination of plate leads and intercell connector; and elimination of internal plate current collector. Increased voltage through: elimination of resistance of current collector; elimination of resistance of plate lead; and elimination of resistance of intercell connector. EPI worked previously on development of a secondary bipolar silver zinc battery. This development demonstrated the electrical capability of the system and manufacturing techniques. One difficulty with this development was mechanical problems with the seals. However, recent improvements in plastics and adhesives should eliminate the major problem of maintaining a seal around the periphery of the bipolar module. The seal problem is not as significant for a primary battery application or for a requirement for only a few discharge cycles. A second difficulty encountered was with activation (introducing electrolyte into the cell) and with venting gas from the cell without loss of electrolyte. During previous work, the following projections for energy density were made from test data for a high power system which demonstrated in excess of 50 discharge/charge cycles. Projected

  10. Thyroid Functions and Bipolar Affective Disorder

    Directory of Open Access Journals (Sweden)

    Subho Chakrabarti

    2011-01-01

    Full Text Available Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder. Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder. The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder. Lithium-treatment has potent antithyroid effects and can induce hypothyroidism or exacerbate a preexisting hypothyroid state. Even minor perturbations of the HPT axis may affect the outcome of bipolar disorder, necessitating careful monitoring of thyroid functions of patients on treatment. Supplementation with high dose thyroxine can be considered in some patients with treatment-refractory bipolar disorder. Neurotransmitter, neuroimaging, and genetic studies have begun to provide clues, which could lead to an improved understanding of the thyroid-bipolar disorder connection, and more optimal ways of managing this potentially disabling condition.

  11. Diagnostic stability in pediatric bipolar disorder

    DEFF Research Database (Denmark)

    Vedel Kessing, Lars; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    BACKGROUND: The diagnostic stability of pediatric bipolar disorder has not been investigated previously. The aim was to investigate the diagnostic stability of the ICD-10 diagnosis of pediatric mania/bipolar disorder.METHODS: All patients below 19 years of age who got a diagnosis of mania....../bipolar disorder at least once in a period from 1994 to 2012 at psychiatric inpatient or outpatient contact in Denmark were identified in a nationwide register.RESULTS: Totally, 354 children and adolescents got a diagnosis of mania/bipolar disorder at least once; a minority, 144 patients (40.7%) got the diagnosis...... at the first contact whereas the remaining patients (210; 59.3%) got the diagnosis at later contacts before age 19. For the latter patients, the median time elapsed from first treatment contact with the psychiatric service system to the first diagnosis with a manic episode/bipolar disorder was nearly...

  12. Compact radio and infrared sources near the centre of the bipolar outflow NGC 2264D

    International Nuclear Information System (INIS)

    A multi-frequency study of the central region of the bipolar outflow NGC 2264D in the Monoceros OB1 molecular cloud has been made in an attempt to localize and understand its driving source. We have detected a weak (≅ 0.6 mJy) radio continuum source at 6 cm, using the VLA; a bright (≅ 270 Jy) H2O maser, using the Haystack Observatory telescope; and near-infrared counterparts to these sources at San Pedro Martir Observatory. Stromgren and JHKL'M photometry of stellar objects in the region was also carried out at this observatory. The star-like object W166, a probable Herbig Be/Ae star, which has strong Hα emission and a near-infrared excess, is located closest to the centroid of the bipolar outflow and is probably its driving source. (author)

  13. New Phosphors for White LEDs

    Institute of Scientific and Technical Information of China (English)

    LIU Ru-Shi

    2004-01-01

    White light-emitting diodes (WLEDs) have matched the emission efficiency of florescent lights and will rapidly spread as light source for homes and offices in the next 5 to 10 years. WLEDs provide a light element having a semiconductor light emitting layer (blue or UV LEDs) and photoluminescence phosphors. GaN-based highly efficient blue InGaN LEDs combined with phosphors can produce white light. These solid-state LED lamps have a number of advantages over conventional incandescent bulbs and halogen lamps, such as high efficiency to convert electrical energy into light, reliability, and long operating lifetime (about 100,000 hours). For the purpose of development of high energy-efficient white light sources, we need to produce highly efficient new phosphors, which can absorb excitation energy from blue or UV LEDs and generate emissions.In this paper, we investigate the development of blue or UV LEDs by the appropriate combination of new phosphors which can lead us to obtain high brightness white light. The criteria of choosing the best phosphors, for blue (380-450 nm) and UV (360-400 nm) LEDs, strongly depends on the absorption and emission of the phosphors. Moreover, the balance light between the light emission from blue LEDs and the yellow YAG:Ce,Gd phosphor is important to obtain white light with high color temperature. The phosphors with high efficiency which can be excited by UV LEDs are important to obtain the white light with high color rendering index.

  14. Drift in LED based Photometer

    DEFF Research Database (Denmark)

    Paasch, Kasper

    1999-01-01

    During the development of a low cost industrial optical sensor an unexpected drift phenomenon has shown to be critical to performance. The sensor is based on LED's as light sources and the main source of error could be tracked to the instability of the spatial radiation pattern of the LED's. This...

  15. Therapeutic Potential of Mood Stabilizers Lithium and Valproic Acid: Beyond Bipolar Disorder

    OpenAIRE

    Chiu, Chi-Tso; Wang, Zhifei; Hunsberger, Joshua G.; Chuang, De-Maw

    2013-01-01

    The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of these drugs in other central nervous system diseases is also gaining support. This article reviews the various mechanisms of action of lithium and VPA gleaned from cellular and animal models of neurologic, neurode...

  16. Design and implementation of fast bipolar clock drivers for CCD imaging systems in space applications

    Science.gov (United States)

    Jayarajan, Jayesh; Kumar, Nishant; Verma, Amarnath; Thaker, Ramkrishna

    2016-05-01

    Drive electronics for generating fast, bipolar clocks, which can drive capacitive loads of the order of 5-10nF are indispensable for present day Charge Coupled Devices (CCDs). Design of these high speed bipolar clocks is challenging because of the capacitive loads that have to be driven and a strict constraint on the rise and fall times. Designing drive electronics circuits for space applications becomes even more challenging due to limited number of available discrete devices, which can survive in the harsh radiation prone space environment. This paper presents the design, simulations and test results of a set of such high speed, bipolar clock drivers. The design has been tested under a thermal cycle of -15 deg C to +55 deg C under vacuum conditions and has been designed using radiation hardened components. The test results show that the design meets the stringent rise/fall time requirements of 50+/-10ns for Multiple Vertical CCD (VCCD) clocks and 20+/-5ns for Horizontal CCD (HCCD) clocks with sufficient design margins across full temperature range, with a pixel readout rate of 6.6MHz. The full design has been realized in flexi-rigid PCB with package volume of 140x160x50 mm3.

  17. Lichtauskopplung aus LEDs mittels Metallnanoteilchen

    OpenAIRE

    Göhler, Tino

    2011-01-01

    Der externe Wirkungsquerschnitt von auf AlGaAs/InGaAlP basierenden Leuchtdioden (LEDs) ist auf Grund von Totalreflexion infolge des hohen Brechungsindex des Halbleitermaterials (n=3...4) beschränkt. Auf die Oberfläche der LED aufgebrachte metallische Nanoteilchen (MNT) können jedoch als Dipolstreuer genutzt werden, um so die Emission der LED zu vergrößern. In dieser Arbeit wurden zunächst einzelne Goldnanoteilchen verschiedener Größe auf einer solchen Leuchtdiode in zwei verschiedenen Der ext...

  18. Phosphors and PDP, LED Technology

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Phosphors for PDP has good prospect for the largepotential of PDP industry. LED technology brings new marketto be developed. Developing phosphors for white LED withhigh efficiency and low light attenuation is an urgent work todo. Application of phosphors in color LED is in initial stage.1. Good Prospect of Phosphors for PDPColor PDP is widely used today. Three-prime-colorphosphor excited by VUV is the key material for color PDP.This makes research on three-prime-color phosphor for colorPDP important. Follow...

  19. Pientalojen energiatehokas led-valaistus

    OpenAIRE

    Viertokangas, Jarmo

    2016-01-01

    Tässä insinöörityössä on tehty tutkimus siitä, miten perinteisen valaistuksen muuttaminen led-valaistukseksi vaikuttaa pientaloenergian kulutukseen. Lisäksi on esimerkkikohteen valaistus- ja sähkösuunnitelma, jossa valaistus on toteutettu energiatehokkaalla led-valaistuksella. Tämä työ on tehty Veikkolan Sähköpalvelu Ky:lle selvitykseksi ja oppaaksi energiatehokkaasta valaistuksesta. Työssä käydään läpi yleisesti erilaisia led-valaistuksen eri vaihtoehtoja pientaloihin sekä mitä mahdollis...

  20. Yleisvalaistuksen muutos LED-valaistukseen

    OpenAIRE

    Heikkinen, Harri

    2015-01-01

    Päättötyön tavoite oli vertailla Mikalo Oy.n asuntokohteiden yleisvalaistuksen nykytilaa mahdolliseen LED-valaistuksella toteutettuun tilaan. Mikalo Oy.n 120.n kohteen yleisvalaistus on merkittävä sähkön kuluttaja, joten selvitys nykyisten valonlähteiden, kuten elohopealamppujen, vaihto voi säästää pitkäai-kaiskäytössä. Uusilla LED-valonlähteillä kulutus saadaan pienennettyä merkittävästi, mutta uusien, tehokkaiden LED-valaisimen hinnat ovat vielä suhteellisen korkealla, ja tämä oli huomi...

  1. Valproate, bipolar disorder and polycystic ovarian syndrome

    Directory of Open Access Journals (Sweden)

    Okanović Milana

    2016-01-01

    Full Text Available Introduction. Polycystic ovarian syndrome is a syndrome of ovarian dysfunction with the principal features of hyperandrogenism and polycystic ovary morphology. A large number of studies conducted on this topic have suggested a possible role of anticonvulsants, particularly valproate, in the pathogenesis or risk factors associated with polycystic ovarian syndrome. Bipolar treatment guidelines from Canada and the United States of America recommend valproate as the first line strategy in the acute treatment of bipolar disorder. Discussion. Most persons with bipolar disorder require maintenance treatment. Long-term administration of valproate in women with bipolar disorder or epilepsy is believed to result in the increased risk of hyperandro­genism, menstrual abnormalities and polycystic ovaries. Valproate may also increase the risk of infertility and other associated symptoms of polycystic ovarian syndrome. Therefore, particular caution is indicated in the use of valproate in women of reproductive age. Conclusion. The treatment of the female patients with bipolar disorder presents various challenges for the clinician. Every woman of reproductive age needs to know the risk and benefits of her pharmacologic treatment options. Bipolar disorder should be considered chronic disorder, whose development is largely affected by hormonal changes and reproductive cycle in women. These issues should be researched more thoroughly in order to opt for the most appropriate treatment in women with bipolar disorder.

  2. Sustainable LED Fluorescent Light Replacement Technology

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-06-30

    Ilumisys and the National Center for Manufacturing Sciences (NCMS) partnered on a three-year project awarded by the United States (U.S.) Department of Energy (DOE), to quantify the impacts of LED lamps, incandescent lamps and fluorescent benchmark lamps over a product lifecycle – i.e. to develop a sustainable design and manufacturing strategy that addresses product manufacturing, use, recycling and disposal scenarios for LED-based lighting. Based on the knowledge gained from extensive product tear-down studies of fluorescent and screw-in lighting products, lifecycle assessment tools, and accelerated lifecycle testing protocols, an interactive Sustainable LED Design Guide has been developed to aid architectural and lighting designers and engineers in making design decisions that consider three important environmental impacts (greenhouse gas emissions, energy use and mercury emission) across all phases of the life of an LED lighting product. Critical information developed for the lifecycle analysis and product feature comparisons is the useful life of the lighting product as well as its performance. The Design Guide is available at www.ncms.org, and was developed based on operational and durability testing of a variety of lighting products including power consumption, light output, and useful life of a lamp in order to allow a more realistic comparison of lamp designs. This report describes the main project tasks, results and innovative features of the lifecycle assessment (LCA)-based design tools, and the key considerations driving the sustainable design of LED lighting systems. The Design Guide incorporates the following three novel features for efficiently evaluating LED lighting features in value-chains: • Bill-of-Materials (BOM) Builder – Designers may import process data for each component and supply functional data for the product, including power, consumption, lumen output and expected useful life. • Environmental Impact Review – Designs are

  3. Brief Report: A Family Risk Study Exploring Bipolar Spectrum Problems and Cognitive Biases in Adolescent Children of Bipolar Parents

    Science.gov (United States)

    Espie, Jonathan; Jones, Steven H.; Vance, Yvonne H.; Tai, Sara J.

    2012-01-01

    Children of parents with bipolar disorder are at increased risk of bipolar spectrum diagnoses. This cross-sectional study explores cognitive factors in the prediction of vulnerability to bipolar disorder. Adolescents at high-risk (with a parent with bipolar disorder; n = 23) and age and gender matched adolescents (n = 24) were recruited. Parent…

  4. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants

    NARCIS (Netherlands)

    Altshuler, LL; Suppes, T; Nolen, WA; Leverich, G; Keck, PE; Frye, MA; Kupka, R; McElroy, SL; Grunze, H; Kitchen, CMR; Post, R; Black, D.O.

    2006-01-01

    Objectives: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. Method: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with bipola

  5. Light pipes for LED measurements

    Science.gov (United States)

    Floyd, S. R.; Thomas, E. F., Jr.

    1976-01-01

    Light pipe directly couples LED optical output to single detector. Small area detector measures total optical output of diode. Technique eliminates thermal measurement problems and channels optical output to remote detector.

  6. Volcanology: Volcanic bipolar disorder explained

    Science.gov (United States)

    Jellinek, Mark

    2014-02-01

    Eruptions come in a range of magnitudes. Numerical simulations and laboratory experiments show that rare, giant super-eruptions and smaller, more frequent events reflect a transition in the essential driving forces for volcanism.

  7. Integrating bipolar electrochemistry and electrochemiluminescence imaging with microdroplets for chemical analysis.

    Science.gov (United States)

    Wu, Suozhu; Zhou, Zhenyu; Xu, Linru; Su, Bin; Fang, Qun

    2014-03-15

    Here we develop a microdroplet sensor based on bipolar electrochemistry and electrochemiluminescence (ECL) imaging. The sensor was constructed with a closed bipolar cell on a hybrid poly(dimethylsioxane) (PDMS)-indium tin oxide (ITO) glass microchip. The ITO microband functions as the bipolar electrode and its two poles are placed in two spatially separate micro-reservoirs predrilled on the PDMS cover. After loading microliter-sized liquid droplets of tris(2,2'-bipyridyl) ruthenium (II)/2-(dibutylamino) ethanol (Ru(bpy)3(2+)/DBAE) and the analyte to the micro-reservoirs, an appropriate external voltage imposed on the driving electrodes could induce the oxidation of Ru(bpy)3(2+)/DBAE and simultaneous reduction of the analyte at the anodic and cathodic poles, respectively. ECL images generated by Ru(bpy)3(2+)/DBAE oxidation at the anodic pole and the electrical current flowing through the bipolar electrode can be recorded for quantitative analyte detection. Several types of quinones were selected as model analytes to demonstrate the sensor performance. Furthermore, the cathodic pole of bipolar electrode can be modified with (3-aminopropyl)triethoxysilane-gold nanoparticles-horseradish peroxidase composites for hydrogen peroxide detection. This microdroplet sensor with a closed bipolar cell can avoid the interference and cross-contamination between analyte solutions and ECL reporting reagents. It is also well adapted for chemical analysis in the incompatible system, e.g., detection of organic compounds insoluble in water by aqueous ECL generation. Moreover, this microdroplet sensor has advantages of simple structure, high sensitivity, fast response and wide dynamic response, providing great promise for chemical and biological analysis. PMID:24140829

  8. Paired structures and bipolar knowledge representation

    DEFF Research Database (Denmark)

    Montero, Javier; Bustince, Humberto; Franco, Camilo;

    In this strictly positional paper we propose a general approach to bipolar knowledge representation, where the meaning of concepts can be modelled by examining their decomposition into opposite and neutral categories. In particular, it is the semantic relationship between the opposite categories...... at the same time the type of neutrality rising in between opposites. Based on this first level of bipolar knowledge representation, paired structures in fact offer the means to characterize a specific bipolar valuation scale depending on the meaning of the concept that has to be verified. In this...

  9. Ionizing radiations simulation on bipolar components

    International Nuclear Information System (INIS)

    This thesis presents the ionizing radiation effects on bipolar components and more specially their behavior facing the total dose. The first part is devoted to the radiation environments with a special attention to the spatial environments and new emergent environments. The specificities of bipolar components are then presented and their behavior facing the interactions. The physical mechanisms bound to the dose rate are also discussed. The second part presents a physical analysis of degradations induced by the cumulated dosimetry on bipolar components and simulation with the ATLAS code. The third part exposes an electric empirical simulation induced by the cumulated dose in static conditions. (A.L.B.)

  10. Research on LED Fishing Light

    OpenAIRE

    Li Tian Hua; Jing Xing

    2013-01-01

    In this study , the semiconductor lighting technology with advantages of energy saving, environmental protection and high rapid response speed is regarded as the fishing light source, which can achieve targets of energy conservation, emission reduction, environmental protection, scientific fishing, etc. Then, the characteristics of LED are described to conduct a comparative analysis with the metal halide light source which has been commonly used in fishing light. The results show that LED is ...

  11. Farbmessung an LED-Systemen

    OpenAIRE

    Herrmann, Franziska

    2013-01-01

    Die Information über die farbliche Abstrahlcharakteristik von LED-Systemen wird immer wichtiger. Durch die zu Glühlampen und Leuchtstofflampen unterschiedliche Erzeugung von weißem Licht kann es bei LED-Systemen zu sichtbaren Farbunterschieden in der Abstrahlcharakteristik kommen. Im Rahmen dieser Arbeit wurde eine Methode zur Darstellung und Beschreibung dieser Farbunterschiede entwickelt, basierend auf gängigen Farbmessmethoden.

  12. Valuing Community-Led Design

    OpenAIRE

    Alexiou, Katerina; Zamenopoulos, Theodore; Alevizou, Giota

    2013-01-01

    The ideas and practice of community-led design, participatory design or co-design have a long-standing tradition, especially in the context of urban design, planning and architecture. Community-led design goes beyond the one-dimensional process of consultation, helping involve people in decision-making throughout the design process, from visioning to implementation. There are many benefits from this approach, from improving civic participation and ensuring more democratic outcomes, to creatin...

  13. Bipolar spintronics: from spin injection to spin-controlled logic

    International Nuclear Information System (INIS)

    An impressive success of spintronic applications has been typically realized in metal-based structures which utilize magnetoresistive effects for substantial improvements in the performance of computer hard drives and magnetic random access memories. Correspondingly, the theoretical understanding of spin-polarized transport is usually limited to a metallic regime in a linear response, which, while providing a good description for data storage and magnetic memory devices, is not sufficient for signal processing and digital logic. In contrast, much less is known about possible applications of semiconductor-based spintronics and spin-polarized transport in related structures which could utilize strong intrinsic nonlinearities in current-voltage characteristics to implement spin-based logic. Here we discuss the challenges for realizing a particular class of structures in semiconductor spintronics: our proposal for bipolar spintronic devices in which carriers of both polarities (electrons and holes) contribute to spin-charge coupling. We formulate the theoretical framework for bipolar spin-polarized transport, and describe several novel effects in two- and three-terminal structures which arise from the interplay between nonequilibrium spin and equilibrium magnetization

  14. Antidepressant chronotherapeutics for bipolar depression.

    Science.gov (United States)

    Benedetti, Francesco

    2012-12-01

    Chronotherapeutics refers to treatments based on the principles of circadian rhythm organization and sleep physiology, which control the exposure to environmental stimuli that act on biological rhythms, in order to achieve therapeutic effects in the treatment of psychiatric conditions. It includes manipulations of the sleep-wake cycle such as sleep deprivation and sleep phase advance, and controlled exposure to light and dark. The antidepressant effects of chronotherapeutics are evident in difficult-to-treat conditions such as bipolar depression, which has been associated with extremely low success rates of antidepressant drugs in naturalistic settings and with stable antidepressant response to chronotherapeutics in more than half of the patients. Recent advances in the study of the effects of chronotherapeutics on neurotransmitter systems, and on the biological clock machinery, allow us to pinpoint its mechanism of action and to transform it from a neglected or "orphan" treatment to a powerful clinical instrument in everyday psychiatric practice. PMID:23393416

  15. Bipolar disorder and neurophysiologic mechanisms

    Directory of Open Access Journals (Sweden)

    Simon M McCrea

    2008-11-01

    Full Text Available Simon M McCreaDepartments of Neurology and Neuroophthalmology, University of British Columbia, 2550 Willow Street, Vancouver, British Columbia, Canada V5Z 3N9Abstract: Recent studies have suggested that some variants of bipolar disorder (BD may be due to hyperconnectivity between orbitofrontal (OFC and temporal pole (TP structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI white matter fiber tractography studies may well be superior to region of interest (ROI DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects.Keywords: bipolar disorder, diffusion tensor imaging, white matter tractography, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, mood dysphoria, creativity, ventral semantic stream, writing ability, artistic aptitude

  16. Cognitive dysfunction in bipolar disorder and schizophrenia

    DEFF Research Database (Denmark)

    Bortolato, Beatrice; Miskowiak, Kamilla W; Köhler, Cristiano A;

    2015-01-01

    Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A neurocognitive profile characterized by widespread cognitive deficits across multiple domains in the context of substantial intellectual impairment, which appears to antedate illness onset, is a replicated...

  17. Internet use by patients with bipolar disorder

    DEFF Research Database (Denmark)

    Bauer, Rita; Conell, Jörn; Glenn, Tasha;

    2016-01-01

    There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with a diagnosis of bipolar disorder in 17 countries completed a paper-based, anonymous...... survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information...... for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage...

  18. White matter microstructure alterations in bipolar disorder

    Science.gov (United States)

    Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Cerruti, Stefania; Rambaldelli, Gianluca; Isola, Miriam; Cerini, Roberto; Dusi, Nicola; Andreone, Nicola; Balestrieri, Matteo; Mucelli, Roberto Pozzi; Tansella, Michele; Brambilla, Paolo

    2012-01-01

    Summary Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls. DWI images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined over regions of interest placed, bilaterally, in the frontal, temporal, parietal, and occipital white matter. Significantly increased ADC values were found in bipolar patients with respect to normal controls in the right temporal lobe, left parietal lobe and bilateral occipital lobes. ADC values did not associate significantly with age or with clinical variables (p>0.05). Diffuse cortical white matter alterations on DWI in bipolar disorder denote widespread disruption of white matter integrity and may be due to altered myelination and/or axonal integrity. PMID:22687164

  19. Are rates of pediatric bipolar disorder increasing?

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2014-01-01

    Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more...... diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all psychiatric hospitals in Denmark, we investigated (1) gender-specific rates of incident pediatric mania/bipolar disorder during a period from 1995 to 2012, (2) whether age and other characteristics for...... pediatric mania/bipolar disorder changed during the calendar period (1995 to 2003 versus 2004 to 2012), and (3) whether the diagnosis is more often made at first psychiatric contact in recent time compared to earlier according to gender. Totally, 346 patients got a main diagnosis of a manic episode (F30) or...

  20. Bipolar Harmonic encoding of CMB correlation patterns

    OpenAIRE

    Joshi, Nidhi; Jhingan, Sanjay; Souradeep, Tarun; Hajian, Amir

    2009-01-01

    Deviations from statistical isotropy can be modeled in various ways, for instance, anisotropic cosmological models (Bianchi models), compact topologies and presence of primordial magnetic field. Signature of anisotropy manifests itself in CMB correlation patterns. Here we explore the symmetries of the correlation function and its implications on the observable measures constructed within the Bipolar harmonic formalism for these variety of models. Different quantifiers within the Bipolar harmo...

  1. Integrating Bipolar Disorder Management in Primary Care

    OpenAIRE

    Kilbourne, Amy M.; Goodrich, David E.; O’Donnell, Allison N.; Miller, Christopher J.

    2012-01-01

    There is growing realization that persons with bipolar disorder may exclusively be seen in primary (general medical) care settings, notably because of limited access to mental health care and stigma in seeking mental health treatment. At least two clinical practice guidelines for bipolar disorder recommend collaborative chronic care models (CCMs) to help integrate mental health care to better manage this illness. CCMs, which include provider guideline support, self-management support, care ma...

  2. Long-term Treatment in Bipolar Disorder

    OpenAIRE

    Meliha Zengin Eroglu; Nurgul Ozpoyraz

    2010-01-01

    Although the importance of long-term prophylactic treatment is certain in bipolar disorder, there is stil debate on how to which patients and evaluate the treatment response. Efficacious long-term treatment can reduce morbidity and mortality significantly and improve quality of life of bipolar patients. The concept of ideal response should also be defined very clearly in order to discuss the difficulties of measuring the effectiveness of the prophylactic treatment. The aims of this paper are ...

  3. QUALITY OF LIFE IN BIPOLAR DISORDER

    OpenAIRE

    Nieznańska, Anna; Baron, Urszula; Jaracz, Krystyna

    2014-01-01

    Background: Among the consequences of bipolar disorder there i s a decreased quality of life, including the deterioration of patients’ social functioning. Material: The paper contains an analysis of 24 major publica tions from the years 2009 to 2014, including 17 related to the assessment of quality of life and 7 articles on the bipolar patients’ social functioning. Results: There were selected 8 factors which are related with the assessment of the quality of life of persons w...

  4. Behavioral Treatment of Insomnia in Bipolar Disorder

    OpenAIRE

    Kaplan, Katherine A; Harvey, Allison G.

    2013-01-01

    Sleep disturbance is common in bipolar disorder. Stimulus control and sleep restriction are powerful, clinically useful behavioral interventions for insomnia, typically delivered as part of cognitive-behavioral therapy for insomnia (CBT-I). Both involve short-term sleep deprivation. The potential for manic or hypomanic symptoms to emerge after sleep deprivation in bipolar disorder raises questions about the appropriateness of these methods for treating insomnia. In a series of patients with b...

  5. A Review of Bipolar Disorder in Adults

    OpenAIRE

    Hilty, Donald M; Leamon, Martin H.; Lim, Russell F.; Kelly, Rosemary H.; Hales, Robert E.

    2006-01-01

    Objective: This article reviews the epidemiology, etiology, assessment, and management of bipolar disorder. Special attention is paid to factors that complicate treatment, including nonadherence, comorbid disorders, mixed mania, and depression. Methods: A Medline search was conducted from January of 1990 through December of 2005 using key terms of bipolar disorder, diagnosis, and treatment. Papers selected for further review included those published in English in peer-reviewed journals, with ...

  6. Bipolar Saline TURP for Large Prostate Glands

    OpenAIRE

    Finley, David S.; Shawn Beck; Szabo, Richard J.

    2007-01-01

    The objective of this study was to evaluate the feasibility of bipolar transurethral resection of the prostate ( TURP) in patients with very large prostate glands and significant comorbidities. Four patients with prostate glands > 160 cc on preoperative volume measurement and ASA class three or higher underwent bipolar TURP with the Gyrus PlasmaKinetic system. Preoperative, operative, and postoperative parameters were studied. The results showed an average ASA class 3.25 (range: 3-4). The ave...

  7. Bipolar cautery forceps: An economical version

    OpenAIRE

    Appukuttan Aswin; Jagadeesh S

    2007-01-01

    Context: Bipolar cautery forceps are an expensive instrument and especially in Government Medical colleges and Government Hospitals, getting a pair is a very tedious and prolonged task due to official reasons. Aims: To make a cheap and easily obtainable bipolar cautery forceps. Settings and Design: The reason for innovation was that the cautery forceps in the department were out of order and we were not getting replacements. Materials and Methods: Made from condemned and damaged forcep...

  8. Homocysteine and cognitive functions in bipolar depression

    OpenAIRE

    Agnieszka Permoda-Osip; Jacek Kisielewski; Jolanta Dorszewska; Janusz Rybakowski

    2014-01-01

    Objectives The aim of the study was to evaluate a relationship between concentrations of hoocysteine (HCY), vitamin B12 and folic acid and disturbances of cognitive functions during acute episode of bipolar depression. Methods 116 patients were studied (93 women, 23 men), aged 20-78 (mean 51±13) years during acute episode of bipolar depression. Depression was evaluated by the 17-item Hamilton’s Depression Rating Scale (HDRS). The following tests measuring cognitive functions were ap...

  9. Bipolar spectrum: Relevant psychological and biological factors

    OpenAIRE

    Terao, Takeshi

    2012-01-01

    The bipolar spectrum is a concept which bridges bipolar I disorder and unipolar depression. As Kraepelin described, there may be continuity across mood disorders. If this is the case, why should we discriminate for drug choice For example, it is generally accepted that mood stabilizers should be used for the bipolar spectrum, whereas antidepressants are for unipolar depression. If these disorders are diagnostically continuous, it is possible that the same drug could be effective in treating b...

  10. O transtorno bipolar na mulher Bipolar disorder in women

    Directory of Open Access Journals (Sweden)

    Alexandro de Borja Gonçalves Guerra

    2005-01-01

    Full Text Available Diferenças sexuais, descritas em vários transtornos psiquiátricos, também parecem estar presentes no transtorno afetivo bipolar (TAB. A prevalência do TAB tipo I se distribui igualmente entre mulheres e homens. Mulheres parecem estar sujeitas a um risco maior de ciclagem rápida e mania mista, condições que fariam do TAB um transtorno com curso mais prejudicial no sexo feminino. Uma diátese depressiva mais marcante, uso excessivo de antidepressivos e diferenças hormonais surgem como hipóteses para explicar essas diferenças fenomenológicas, apesar das quais, mulheres e homens parecem responder igualmente ao tratamento medicamentoso. A indicação de anticonvulsivantes como primeira escolha em mulheres é controversa, a não ser para o tratamento da mania mista e, talvez, da ciclagem rápida. O tratamento do TAB na gravidez deve levar em conta tanto os riscos de exposição aos medicamentos quanto à doença materna. A profilaxia do TAB no puerpério está fortemente indicada em decorrência do grande risco de recorrência da doença nesse período. Embora, de modo geral, as medicações psicotrópicas estejam contra-indicadas durante a amamentação, entre os estabilizadores do humor, a carbamazepina e o valproato são mais seguros do que o lítio. Mais estudos são necessários para a confirmação das diferenças de curso do TAB entre mulheres e homens e a investigação de possíveis diferenças na efetividade dos tratamentos.Gender differences, described in several psychiatric disorders, seem to be also present in bipolar disorder (BD. The prevalence of bipolar I disorder is equally distributed between women and men. Women seem to be at higher risk for rapid cycling and mixed mania, conditions that could make BD a disorder with a more severe course in the female sex. A marked depressive diathesis among women, greatest use of antidepressants and hormonal differences have been mentioned as hypotheses to explain these

  11. Bipolar II compared with bipolar I disorder: baseline characteristics and treatment response to quetiapine in a pooled analysis of five placebo-controlled clinical trials of acute bipolar depression

    OpenAIRE

    Datto, Catherine; Pottorf, William J.; Feeley, Louisa; LaPorte, Scott; Liss, Charlie

    2016-01-01

    Background Bipolar I and II represent the most common and severe subtypes of bipolar disorder. Although bipolar I disorder is relatively well studied, the clinical characteristics and response to treatment of patients with bipolar II disorder are less well understood. Methods To compare the severity and burden of illness of patients with bipolar II versus bipolar I disorder, baseline demographic, clinical, and quality of life data were examined in 1900 patients with bipolar I and 973 patients...

  12. Values-Led Participatory Design

    DEFF Research Database (Denmark)

    Iversen, Ole Sejer; Halskov, Kim; Leong, Tuck Wah

    2012-01-01

    The widespread use of participatory design (PD) has meant that different approaches and conceptualisations exist in this field today. In this article, it is argued that one fruitful approach is to rekindle a concern for values in design, focusing upon values as the engine that drives activities i...

  13. Rumination in bipolar disorder: evidence for an unquiet mind

    Directory of Open Access Journals (Sweden)

    Ghaznavi Sharmin

    2012-01-01

    Full Text Available Abstract Depression in bipolar disorder has long been thought to be a state characterized by mental inactivity. However, recent research demonstrates that patients with bipolar disorder engage in rumination, a form of self-focused repetitive cognitive activity, in depressed as well as in manic states. While rumination has long been associated with depressed states in major depressive disorder, the finding that patients with bipolar disorder ruminate in manic states is unique to bipolar disorder and challenges explanations put forward for why people ruminate. We review the research on rumination in bipolar disorder and propose that rumination in bipolar disorder, in both manic and depressed states, reflects executive dysfunction. We also review the neurobiology of bipolar disorder and recent neuroimaging studies of rumination, which is consistent with our hypothesis that the tendency to ruminate reflects executive dysfunction in bipolar disorder. Finally, we relate the neurobiology of rumination to the neurobiology of emotion regulation, which is disrupted in bipolar disorder.

  14. The development of lurasidone for bipolar depression.

    Science.gov (United States)

    Loebel, Antony; Xu, Jane; Hsu, Jay; Cucchiaro, Josephine; Pikalov, Andrei

    2015-11-01

    Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, either as monotherapy or adjunctive therapy in combination with mood stabilizers. Lurasidone is an atypical antipsychotic drug that was initially developed for the treatment of schizophrenia. Since no previous atypical antipsychotic development program had proceeded directly from work on schizophrenia to bipolar depression, the decision to focus on this indication represented an innovation in central nervous system drug development and was designed to address a clinically significant unmet need. The current review summarizes key results of a clinical development program undertaken to characterize the efficacy and safety of lurasidone in patients diagnosed with bipolar depression. Lurasidone is currently the only treatment for bipolar depression approved in the United States as both a monotherapy and an adjunctive therapy with lithium or valproate. The approval of lurasidone expands available treatment options for patients with bipolar depression and provides a therapy with an overall favorable risk-benefit profile. PMID:26771990

  15. The role of sleep in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Gold AK

    2016-06-01

    Full Text Available Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C functioning and sleep–wake homeostasis (process S on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. Keywords: bipolar disorder, circadian rhythms, sleep–wake homeostasis

  16. Attention and psychomotor functioning in bipolar depression.

    Science.gov (United States)

    Burdick, Katherine E; Gunawardane, Nisali; Goldberg, Joseph F; Halperin, Jeffrey M; Garno, Jessica L; Malhotra, Anil K

    2009-04-30

    The objective of this study was to assess psychomotor functioning and attention in individuals with bipolar disorder during the depressed phase of illness. Measures of attention and psychomotor functioning were administered to a sample of 24 bipolar I and II patients and a matched sample of healthy controls. Relative to the healthy controls, the bipolar sample demonstrated evidence of psychomotor slowing and revealed deficits on measures of effortful attention, yet demonstrated comparable performance on measures of automatic attention. In the bipolar sample, we detected significant correlations among measures of psychomotor functioning and some aspects of attention and a strong relationship between the severity of depression and psychomotor functioning, but no direct relationship between attention deficits and depressive symptomatology. These results suggest an attentional impairment during the depressed phase of bipolar disorder that may be specific to effortful processing, while automatic processes remain relatively intact. Associations among indices of attention deficits and psychomotor slowing may be indicative of similarities in the underlying neurobiology of these frequently co-occurring symptom domains in depressed individuals with bipolar disorder. PMID:19272656

  17. Impurity Influence on Nitride LEDs

    Directory of Open Access Journals (Sweden)

    O.I. Rabinovich

    2014-07-01

    Full Text Available Light emitting diodes (LEDs are widely used nowadays. They are used in major parts of our life. But it is still necessary to improve their characteristics. In this paper the impurity and Indium atoms influence on the LEDs characteristics is investigated by computer simulation. Simulation was carried out in Sim Windows. The program was improved for this purpose by creating new files for AlGaInN heterostructure and devices including more than 25 basic parameters. It was found that characteristics depend on impurity and indium atoms changes a lot. The optimum impurity concentration for doping barriers between quantum wells was achieved. By varying impurity and Indium concentration the distribution in AlGaInN heterostructure LEDs characteristics could be improved.

  18. LED-valaisimen markkinoille saattaminen

    OpenAIRE

    Ahola, Sami

    2015-01-01

    LED-valaisimien käyttö on yleistynyt sisä- ja ulkotilojen valaistuksessa ja niiden käyttö lisääntyy tulevien vuosien aikana nopeasti. LED-tekniikkaa hyödyntäviä valaisimia ja lamppuja on jo tällä hetkellä markkinoilla suuria määriä. Tämän opinnäytetyön tavoite oli laatia yhteenveto sähkölaitteen markkinoille saattamisesta huomioiden LED-valaisimien erityispiirteet. Työssä perehdyttiin sähkölaitteen markkinoille saattamisen prosessiin direktiivien, lainsäädännön ja standardien pohjalta. Ty...

  19. Current-voltage model of LED light sources

    DEFF Research Database (Denmark)

    Beczkowski, Szymon; Munk-Nielsen, Stig

    2012-01-01

    Amplitude modulation is rarely used for dimming light-emitting diodes in polychromatic luminaires due to big color shifts caused by varying magnitude of LED driving current and nonlinear relationship between intensity of a diode and driving current. Current-voltage empirical model of light...... and the actual measured one, is much lower than the just noticeable color difference (mean ΔEab* = 0.15). The model can be used e.g. as a color feedback mechanism in high power trichromatic luminaires such as profile lamps....

  20. Linkages between NAMA - LEDS - MRV

    DEFF Research Database (Denmark)

    Agyemang-Bonsu, William; Benioff, Ron; Cox, Sadie;

    Low Emission Development Strategies (LEDS), Nationally Appropriate Mitigation Actions (NAMAs) and Monitoring, Reporting and Verification (MRV) are three of the key conceptual components emerging as part of the global architecture for a new climate agreement by 2015. The three components are...... how the three components are conceptually interlinked. Identifying the linkages can inform the work on each component and strengthen coordination of work in the context of the three big partnerships; the International Partnership on Mitigation and MRV, the LEDS Global Partnership and the NAMA...

  1. LED-belysning och brukaren

    OpenAIRE

    Adanko, Carina; Küller, Marianne

    2014-01-01

    Ljusforskning är om något diversifierad och omfattar teorier och metoder från skilda discipliner som teknik, medicin och samhällsvetenskap. Det finns också en förväntan att erhållna forskningsresultat skall kunna appliceras direkt i verkliga miljöer. I och med introduktionen av LED har många tidigare studier som behandlat glödlampor, lysrör och andra ljuskällor inaktualiserats. Ny kunskap - och ny forskning - krävs. En inventering av aktuell humanrelaterad LED-forskning genomfördes under 2013...

  2. Temporal order of bipolar cell genesis in the neural retina

    Directory of Open Access Journals (Sweden)

    Chen C-M Amy

    2008-01-01

    Full Text Available Abstract Background Retinal bipolar cells comprise a diverse group of neurons. Cone bipolar cells and rod bipolar cells are so named for their connections with cone and rod photoreceptors, respectively. Morphological criteria have been established that distinguish nine types of cone bipolar cells and one type of rod bipolar cell in mouse and rat. While anatomical and physiological aspects of bipolar types have been actively studied, little is known about the sequence of events that leads to bipolar cell type specification and the potential relationship this process may have with synapse formation in the outer plexiform layer. In this study, we have examined the birth order of rod and cone bipolar cells in the developing mouse and rat in vivo. Results Using retroviral lineage analysis with the histochemical marker alkaline phosphatase, the percentage of cone and rod bipolar cells born on postnatal day 0 (P0, P4, and P6 were determined, based upon the well characterized morphology of these cells in the adult rat retina. In this in vivo experiment, we have demonstrated that cone bipolar genesis clearly precedes rod bipolar genesis. In addition, in the postnatal mouse retina, using a combination of tritiated-thymidine birthdating and immunohistochemistry to distinguish bipolar types, we have similarly found that cone bipolar genesis precedes rod bipolar genesis. The tritiated-thymidine birthdating studies also included quantification of the birth of all postnatally generated retinal cell types in the mouse. Conclusion Using two independent in vivo methodologies in rat and mouse retina, we have demonstrated that there are distinct waves of genesis of the two major bipolar cell types, with cone bipolar genesis preceding rod bipolar genesis. These waves of bipolar genesis correspond to the order of genesis of the presynaptic photoreceptor cell types.

  3. Bipolar affective disorder: A review of novel forms of therapy

    Directory of Open Access Journals (Sweden)

    Dziwota Ewelina

    2015-06-01

    Full Text Available Normothymic, antidepressant and antipsychotic pharmaceutics are, in accordance with international guidelines, employed both in the therapy and the prevention of bipolar disorder (BD. Long-term studies on the mechanisms of action of such medications, as well as on the pathogenetic background of BD, have led to the discovery of effective, albeit unconventional pharmacotherapeutic approaches. These methods have the potential to successfully treat mania and depression, as well as to counter affective episode relapse. Allopurinol - commonly used to treat gout, secondary hyperuricemia and Lesch-Nyhan syndrome, acts by inhibiting the synthesis of uric acid, levels of which are often increased in manic patients. Due to this, an evaluation of the potential effect of allopurinol on the reduction of mania symptoms seems to be reasonable. Additionally, the numerable research papers coming out of research regarding the role of purine neurotransmitters in mood alterations, indicate that adenosine agonists act analogously to dopamine antagonists.

  4. Distractions in Everyday Driving

    Science.gov (United States)

    ... while driving, which is one of the reasons distracted driving is such a big problem. Driver inattention is ... you’re doing any of these things while driving, you become distracted in ways that increase your risk of crashing. ...

  5. Terapia comportamental cognitiva para pessoas com transtorno bipolar Cognitive behavioral therapy for bipolar disorders

    OpenAIRE

    Francisco Lotufo Neto

    2004-01-01

    Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  6. Subcortical Gray Matter Volume Abnormalities in Healthy Bipolar Offspring: Potential Neuroanatomical Risk Marker for Bipolar Disorder?

    Science.gov (United States)

    Ladouceur, Cecile D.; Almeida, Jorge R. C.; Birmaher, Boris; Axelson, David A.; Nau, Sharon; Kalas, Catherine; Monk, Kelly; Kupfer, David J.; Phillips, Mary L.

    2008-01-01

    A study is conducted to examine the extent to which bipolar disorder (BD) is associated with gray matter volume abnormalities in brain regions in healthy bipolar offspring relative to age-matched controls. Results show increased gray matter volume in the parahippocampus/hippocampus in healthy offspring at genetic risk for BD.

  7. Clinical, Demographic, and Familial Correlates of Bipolar Spectrum Disorders among Offspring of Parents with Bipolar Disorder

    Science.gov (United States)

    Goldstein, Benjamin I.; Shamseddeen, Wael; Axelson, David A.; Kalas, Cathy; Monk, Kelly; Brent, David A.; Kupfer, David J.; Birmaher, Boris

    2010-01-01

    Objective: Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). Method: Subjects included 388 offspring, ages 7-17 years,…

  8. Multicolor, High Efficiency, Nanotextured LEDs

    Energy Technology Data Exchange (ETDEWEB)

    Jung Han; Arto Nurmikko

    2011-09-30

    We report on research results in this project which synergize advanced material science approaches with fundamental optical physics concepts pertaining to light-matter interaction, with the goal of solving seminal problems for the development of very high performance light emitting diodes (LEDs) in the blue and green for Solid State Lighting applications. Accomplishments in the duration of the contract period include (i) heteroepitaxy of nitrogen-polar LEDs on sapphire, (ii) heteroepitaxy of semipolar (11{bar 2}2) green LEDs on sapphire, (iii) synthesis of quantum-dot loaded nanoporous GaN that emits white light without phosphor conversion, (iv) demonstration of the highest quality semipolar (11{bar 2}2) GaN on sapphire using orientation-controlled epitaxy, (v) synthesis of nanoscale GaN and InGaN medium, and (vi) development of a novel liftoff process for manufacturing GaN thin-film vertical LEDs. The body of results is presented in this report shows how a solid foundation has been laid, with several noticeable accomplishments, for innovative research, consistent with the stated milestones.

  9. White LED motorcycle headlamp design

    Science.gov (United States)

    Sun, Wen-Shing

    2015-09-01

    The motorcycle headlamp is composed of a white LED module, an elliptical reflector, a parabolic reflector and a toric lens. We use non-sequential ray to improve the optical efficiency of the compound reflectors. Using the toric lens can meet ECE_113 regulation and obtain a good uniformity.

  10. UV-LED photopolymerised monoliths

    Czech Academy of Sciences Publication Activity Database

    Abele, S.; Nie, F.; Foret, František; Paull, B.; Macka, M.

    2008-01-01

    Roč. 133, č. 7 (2008), s. 864-866. ISSN 0003-2654 R&D Projects: GA AV ČR KAN400310651 Institutional research plan: CEZ:AV0Z40310501 Keywords : photopolymerisation * UV- LED * polymethacrylate monolith Subject RIV: CB - Analytical Chemistry, Separation Impact factor: 3.761, year: 2008

  11. MLL5 maintains spindle bipolarity by preventing aberrant cytosolic aggregation of PLK1.

    Science.gov (United States)

    Zhao, Wei; Liu, Jie; Zhang, Xiaoming; Deng, Lih-Wen

    2016-03-28

    Faithful chromosome segregation with bipolar spindle formation is critical for the maintenance of genomic stability. Perturbation of this process often leads to severe mitotic failure, contributing to tumorigenesis. MLL5 has been demonstrated to play vital roles in cell cycle progression and the maintenance of genomic stability. Here, we identify a novel interaction between MLL5 and PLK1 in the cytosol that is crucial for sustaining spindle bipolarity during mitosis. Knockdown of MLL5 caused aberrant PLK1 aggregation that led to acentrosomal microtubule-organizing center (aMTOC) formation and subsequent spindle multipolarity. Further molecular studies revealed that the polo-box domain (PBD) of PLK1 interacted with a binding motif on MLL5 (Thr887-Ser888-Thr889), and this interaction was essential for spindle bipolarity. Overexpression of wild-type MLL5 was able to rescue PLK1 mislocalization and aMTOC formation in MLL5-KD cells, whereas MLL5 mutants incapable of interacting with the PBD failed to do so. We thus propose that MLL5 preserves spindle bipolarity through maintaining cytosolic PLK1 in a nonaggregated form. PMID:27002166

  12. LED lighting. Special issue; Led-verlichting. Themanummer

    Energy Technology Data Exchange (ETDEWEB)

    Adams, T. [Spectrum Advies en Design, Putten (Netherlands); Derksen, A. [Isso, Rotterdam (Netherlands); Van Mil, R.; Van Lieshout, M.; Vollebregt, R.

    2010-10-15

    In four articles in this issue the focus on illuminance by LEDs: interview with the director of Velux Netherlands, expert in skylights and daylight solutions; the influence of lighting on the cognitive performance of students; the use of energy efficient, dynamic lighting; the Isso publication (number 90) 'Energy-efficient lighting and around buildings'; and the promise of the OLED flat skylight. [Dutch] In vier artikelen wordt in deze aflevering aandacht besteed aan verlichting d.m.v. LEDs: (interview met de directeur van Velux Nederland, specialist in dakramen en daglichtoplossingen; de invloed van verlichting op leerprestaties van scholieren; het gebruik van energie efficiente, dynamisch verlichtingssystemen; de Isso-publicatie (nummer 90) 'Energie-efficiente verlichting in en rondom gebouwen; en de belofte van de platvallichtbron Oled.

  13. Processamento cognitivo "Teoria da Mente" no transtorno bipolar Cognitive "Theory of Mind" processing in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Hélio Anderson Tonelli

    2009-12-01

    Full Text Available OBJETIVO: O transtorno afetivo bipolar está associado ao comprometimento funcional persistente. Apesar de muitas pesquisas demonstrarem que bipolares podem apresentar déficits cognitivos, um número menor de trabalhos avaliou o papel de prejuízos no processamento cognitivo social, a Teoria da Mente (relacionado à capacidade de inferir estados mentais, no aparecimento de sintomas e complicações sociais em bipolares. O objetivo deste trabalho é o de revisar sistemática e criticamente a literatura sobre possíveis alterações do processamento Teoria da Mente no transtorno afetivo bipolar. MÉTODO: Foi realizada uma busca na base de dados Medline por trabalhos publicados em língua inglesa, alemã, espanhola ou portuguesa nos últimos 20 anos, utilizando a frase de busca "Bipolar Disorder"[Mesh] AND "Theory of Mind". Foram procurados por estudos clínicos envolvendo indivíduos bipolares e que empregaram uma ou mais tarefas cognitivas desenvolvidas para a avaliação de habilidades Teoria da Mente. Foram excluídos os relatos de caso e cartas ao editor. A busca inicial resultou em cinco artigos, sendo selecionados quatro. Outros quatro foram também selecionados a partir da leitura dos artigos acima. DISCUSSÃO: Os artigos selecionados avaliaram populações de bipolares adultos e pediátricos, incluindo indivíduos eutímicos, maníacos e deprimidos. A maioria dos trabalhos avaliados sugere que existam prejuízos no processamento Teoria da Mente em portadores de transtorno afetivo bipolar e que estes podem estar por trás dos sintomas e dos déficits funcionais do transtorno afetivo bipolar. CONCLUSÃO: Pesquisas futuras a respeito do tema em questão poderão esclarecer muito acerca do papel das alterações sociocognitivas no surgimento dos sintomas do transtorno afetivo bipolar, bem como ajudar no desenvolvimento de estratégias preventivas e terapêuticas do mesmo.OBJECTIVE: Bipolar disorder is associated to persistent functional

  14. LED lamp power management system and method

    Science.gov (United States)

    Gaines, James; Clauberg, Bernd; Van Erp, Josephus A. M.

    2013-03-19

    An LED lamp power management system and method including an LED lamp having an LED controller 58; a plurality of LED channels 60 operably connected to the LED controller 58, each of the plurality of LED channels 60 having a channel switch 62 in series with at least one shunted LED circuit 83, the shunted LED circuit 83 having a shunt switch 68 in parallel with an LED source 80. The LED controller 58 reduces power loss in one of the channel switch 62 and the shunt switch 68 when LED lamp electronics power loss (P.sub.loss) exceeds an LED lamp electronics power loss limit (P.sub.lim); and each of the channel switches 62 receives a channel switch control signal 63 from the LED controller 58 and each of the shunt switches 68 receives a shunt switch control signal 69 from the LED controller 58.

  15. LED lamp color control system and method

    Science.gov (United States)

    Gaines, James; Clauberg, Bernd; Van Erp, Josephus A.M.

    2013-02-05

    An LED lamp color control system and method including an LED lamp having an LED controller 58; and a plurality of LED channels 60 operably connected to the LED controller 58, each of the plurality of LED channels 60 having a channel switch 62 in series with at least one shunted LED circuit 83, the shunted LED circuit 83 having a shunt switch 68 in parallel with an LED source 80. The LED controller 58 determines whether the LED source 80 is in a feedback controllable range, stores measured optical flux for the LED source 80 when the LED source 80 is in the feedback controllable range, and bypasses storing the measured optical flux when the LED source 80 is not in the feedback controllable range.

  16. Low Cost Heart Rate Monitor Using Led-Led Sensor

    OpenAIRE

    Ahmed Mahrous Ragib

    2009-01-01

    A high sensitivity, low power and low cost sensor has been developed for photoplethysmography (PPG) measurement. The PPG principle was applied to follow the dilatation and contraction of skin blood vessels during the cardiac cycle. A standard light emitting diodes (LEDs) has been used as a light emitter and detector, and in order to reduce the space, cost and power, the classical analogue-to-digital converters (ADCs) replaced by the pulse-based signal conversion techniques. A general purpose ...

  17. LedTrix - Led-teknologian osaamispankki : Loppuraportti

    OpenAIRE

    Turunen, Lauri; Mönkkönen, Kari

    2014-01-01

    Tämä julkaisu on Ledtrix – Led-teknologian osaamispankki -hankkeen loppuraportti.Hanke toteutettiin vuosina 2010–2014. Hanketta rahoittivat Innovaatiorahoituskeskus Tekesin (Euroopan aluekehitysrahasto EAKR) lisäksi tutkimusosapuolet sekä yritykset. Hanke toteutettiin kolmena rinnakkaishankkeena, joissa tutkimusosapuolina olivat Karelia-ammattikorkeakoulun Liiketalouden ja tekniikan keskus, Itä-Suomen yliopiston fysiikan ja matematiikan laitos sekä Mikkelin ammattikorkeakoulu (30.3.2013 asti ...

  18. Big data for bipolar disorder.

    Science.gov (United States)

    Monteith, Scott; Glenn, Tasha; Geddes, John; Whybrow, Peter C; Bauer, Michael

    2016-12-01

    The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big data and advances in the ability to analyze these data. The impact of big data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of big data today are electronic medical records (EMR), claims, and registry data from providers and payers. In the near future, data created by patients from active monitoring, passive monitoring of Internet and smartphone activities, and from sensors may be integrated with the EMR. Diverse data sources from outside of medicine, such as government financial data, will be linked for research. Over the long term, genetic and imaging data will be integrated with the EMR, and there will be more emphasis on predictive models. Many technical challenges remain when analyzing big data that relates to size, heterogeneity, complexity, and unstructured text data in the EMR. Human judgement and subject matter expertise are critical parts of big data analysis, and the active participation of psychiatrists is needed throughout the analytical process. PMID:27068058

  19. LED应用%LED Operation

    Institute of Scientific and Technical Information of China (English)

    Michael Krickl

    2004-01-01

    LED(发光二极管)用于状态显示和矩阵面板已经很多年了。现在,可选用的LED包括新开发的蓝光和白光LED(广泛用于便携装置)以及普遍存在的绿光、红光和黄光LED。白光LED可做为彩显的理想背景照明。但是,在为LED设计电源时应注意这些新LED器件的固有特性。本文描述新、老LED的特性以及激励它们所需的电源性能。

  20. Colorimetric characterization of LED luminaires

    Science.gov (United States)

    Costa, C. L. M.; Vieira, R. R.; Pereira, R. C.; Silva, P. V. M.; Oliveira, I. A. A.; Sardinha, A. S.; Viana, D. D.; Barbosa, A. H.; Souza, L. P.; Alvarenga, A. D.

    2015-01-01

    The Optical Metrology Division of Inmetro - National Institute of Metrology, Quality and Technology has recently started the colorimetric characterization of lamps by implementing Correlated Color Temperature (CCT) and Color Rendering Index (CRI) measurements of incandescent lamps, followed by the CFL, and LED lamps and luminaires. Here we present the results for the verification of the color characterization of samples of SSL luminaires for public as well as indoor illumination that are sold in Brazil.

  1. Colorimetric characterization of LED luminaires

    International Nuclear Information System (INIS)

    The Optical Metrology Division of Inmetro – National Institute of Metrology, Quality and Technology has recently started the colorimetric characterization of lamps by implementing Correlated Color Temperature (CCT) and Color Rendering Index (CRI) measurements of incandescent lamps, followed by the CFL, and LED lamps and luminaires. Here we present the results for the verification of the color characterization of samples of SSL luminaires for public as well as indoor illumination that are sold in Brazil

  2. Luminescent ceramics for LED conversion

    Science.gov (United States)

    Raukas, M.; Wei, G.; Bergenek, K.; Kelso, J.; Zink, N.; Zheng, Y.; Hannah, M.; Stough, M.; Wirth, R.; Linkov, A.; Jermann, F.; Eisert, D.

    2011-03-01

    Many LED-based applications would benefit from more efficient and/or high lumen output devices that enable usage in both white and single color illumination schemes. In the present article we briefly review the materials research history leading to optical ceramic converters and discuss their typical characteristics. Recently demonstrated high performance values in terms of efficacy and external quantum efficiency in orange (amber) spectral region are described.

  3. Application of Bipolar Fuzzy Sets in Graph Structures

    Directory of Open Access Journals (Sweden)

    Muhammad Akram

    2016-01-01

    Full Text Available A graph structure is a useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we apply the concept of bipolar fuzzy sets to graph structures. We introduce certain notions, including bipolar fuzzy graph structure (BFGS, strong bipolar fuzzy graph structure, bipolar fuzzy Ni-cycle, bipolar fuzzy Ni-tree, bipolar fuzzy Ni-cut vertex, and bipolar fuzzy Ni-bridge, and illustrate these notions by several examples. We study ϕ-complement, self-complement, strong self-complement, and totally strong self-complement in bipolar fuzzy graph structures, and we investigate some of their interesting properties.

  4. A minimum thermodynamic model for the bipolar seesaw

    DEFF Research Database (Denmark)

    Stocker, Thomas F.; Johnsen, Sigfus Johann

    2003-01-01

    Bipolar seesaw, synchronization of Antarctic and Greenland ice cores, Dansgaard-Oeschger events, north-south connection......Bipolar seesaw, synchronization of Antarctic and Greenland ice cores, Dansgaard-Oeschger events, north-south connection...

  5. Immune activation by casein dietary antigens in bipolar disorder

    NARCIS (Netherlands)

    Severance, E.G.; Dupont, D.; Dickerson, F.B.; Stallings, C.R.; Origoni, A.E.; Krivogorsky, B.; Yang, S.; Haasnoot, W.; Yolken, R.H.

    2010-01-01

    Objectives: Inflammation and other immune processes are increasingly linked to psychiatric diseases. Antigenic triggers specific to bipolar disorder are not yet defined. We tested whether antibodies to bovine milk caseins were associated with bipolar disorder, and whether patients recognized differe

  6. Anticonvulsant Drugs for Nerve Pain, Bipolar Disorder and Fibromyalgia

    Science.gov (United States)

    Anticonvulsant Drugs for Nerve Pain, Bipolar Disorder &Fibromyalgia: Choosing What’sRight for You What are anticonvulsant drugs? Anticonvulsants are drugs used to treat seizures. They are also used to treat bipolar ...

  7. Cytokines in bipolar disorder vs. healthy control subjects

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Braüner, Julie Vestergaard; Kessing, Lars Vedel;

    2013-01-01

    Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states....

  8. Differences between Depression Episodes of Bipolar Disorder I and II

    Directory of Open Access Journals (Sweden)

    Leman Inanc

    2013-09-01

    Full Text Available In 1975 Fieve and Dunner made the distinction between hypomania and mania as hypomania does not usually cause social and occupational impair-ment and hospitalization is not needed, moreover patients do not experience psychosis. Bipolar disorder type I is defined by the presence of manic and depressive episodes and differs from Bipolar disorder type II characterized with hipomanic and depressive episodes. Bipolar disorder type I and II do not differ in their depressive episodes. It is still point of contention whether bipolar type II is a variant of bipolar disorder type I or is positioned on the spectrum between bipolar type I and unipolar disorder. Even there are some similarities in characteristics of depressive episodes and outcome features of different bipolar disorder subtypes, there are differences that can be useful in differential diagnosis and treatment. This paper aims to focus on those differences between bipolar disorder type I and II.

  9. Lithium Beats Newer Meds for Bipolar Disorder, Study Finds

    Science.gov (United States)

    ... for Treatment and Research of Bipolar Disorder at Zucker Hillside Hospital in Glen Oaks, N.Y., and ... Center for Treatment and Research of Bipolar Disorder, Zucker Hillside Hospital, Glen Oaks, N.Y.; May 11, ...

  10. [Non pharmacological treatment for bipolar disorder].

    Science.gov (United States)

    Mirabel-Sarron, Christine; Giachetti, Raphaël

    2012-12-01

    Bipolar disorder is a chronic and recurring disorder associated with significant psychosocial impairment. A number of psychosocial interventions have been developed to address impairment. The consensus makes mood stabilizer the treatment of bipolar disorder. However, numerous patients are not in complete remission despite a controlled observance. Every patient can follow a psycho educational program. What this paper adds. The review identifies that a range of interventions have demonstrated efficacy in extended periods of euthymia, improved social and occupational functioning and alleviation of subsyndromal symptoms. Adjunctive, short-term psychotherapies have been shown to offer fairly consistent benefits to bipolar disorder patients. Cognitive-behavioural therapy, family-focused therapy, and psychoeducation offer the most robust efficacy in regard to relapse prevention. The most complex situations including comorbidities can be helped by behavioral and cognitive therapy for bipolar disorder. Evaluations emphasize positive impact. The psychosocial interventions reviewed provide mental health nurses with evidence-based approaches to improving mental health care for patients with bipolar disorder. There is a need for mental health nurses to conduct high quality trials of the clinical effectiveness of these interventions. PMID:23395231

  11. Bipolar batteries based on Ebonex ® technology

    Science.gov (United States)

    Loyns, A. C.; Hill, A.; Ellis, K. G.; Partington, T. J.; Hill, J. M.

    Continuing work by Atraverda on the production of a composite-laminate form of the Ebonex ® material, that can be cheaply formulated and manufactured to form substrate plates for bipolar lead-acid batteries, is described. Ebonex ® is the registered trade name of a range of titanium suboxide ceramic materials, typically Ti 4O 7 and Ti 5O 9, which combine electrical conductivity with high corrosion and oxidation resistance. Details of the structure of the composite, battery construction techniques and methods for filling and forming of batteries are discussed. In addition, lifetime and performance data obtained by Atraverda from laboratory bipolar lead-acid batteries and cells are presented. Battery production techniques for both conventional monopolar and bipolar batteries are reviewed. The findings indicate that substantial time and cost savings may be realised in the manufacture of bipolar batteries in comparison to conventional designs. This is due to the fewer processing steps required and more efficient formation. The results indicate that the use of Ebonex ® composite material as a bipolar substrate will provide lightweight and durable high-voltage lead-acid batteries suitable for a wide range of applications including advanced automotive, stationary power and portable equipment.

  12. [Pseudocholinesterase activity in type 1 bipolar patients].

    Science.gov (United States)

    Ezzaher, Asma; Haj Mouhamed, Dhouha; Mechri, Anwar; Neffati, Fadoua; Douki, Wahiba; Gaha, Lotfi; Najjar, Mohamed Fadhel

    2012-01-01

    This study aims to investigate the variation of pseudocholinesterase activity (BuChE) in bipolar patients and to explore its relation to the clinical and therapeutic characteristics of this disease. Our study included 105 patients with bipolar disorder and 100 control subjects aged 38.7 ± 12.2 and 36.4 ± 15.7 y, respectively. BuChE was determined by kinetic methods on Cobas Integra 400 plus™. Compared with controls, patients had a significantly higher pseudocholinesterase activity. Moreover, this increase was significantly associated (p = 0.001) with bipolar disorder with sensibility of 58% and specificity of 62% at threshold of 7392 IU/L. There was no significant change in pseudocholinesterase activity in relation to illness episodes and treatment, whereas the lowest values of this activity were seen in euthymic patients and those taking psychotics. Therefore, this activity is a real interest in the biological monitoring of patients as a risk factor for neurodegenerative diseases associated with bipolar disorder. But it would be most useful to evaluate their interest as a predictor of bipolar disorder in patients at risk. PMID:22294139

  13. QUALITY OF LIFE IN BIPOLAR DISORDER

    Directory of Open Access Journals (Sweden)

    Nieznańska, Anna

    2014-12-01

    Full Text Available Background: Among the consequences of bipolar disorder there i s a decreased quality of life, including the deterioration of patients’ social functioning. Material: The paper contains an analysis of 24 major publica tions from the years 2009 to 2014, including 17 related to the assessment of quality of life and 7 articles on the bipolar patients’ social functioning. Results: There were selected 8 factors which are related with the assessment of the quality of life of persons with a diagnosis of bipolar disorder: the presence of depressive symptoms, substance use, sleep deficit, religious activity and social support, internalized stigma, suicide attempts in the past, the perception of emotions and impulsivity. It was defined that social functioning of bipolar patients is dependent on the emotional state of patients, and in particular the presence of depressive symptoms. It is dependent also on patients’ cognitive performance and internalized stigma. Conclusions: Assistance in mastering the first symptoms of a depressive phase can help bipolar patients in their smooth social functioning and quality of life. Taking into account the implementation of appropriate therapy with cognitive exercise and which is aimed at reducing internalized stigma, may contribute to improving the quality of life and improve the patients’ social functioning.

  14. The role of sleep in bipolar disorder

    Science.gov (United States)

    Gold, Alexandra K; Sylvia, Louisa G

    2016-01-01

    Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C) functioning and sleep–wake homeostasis (process S) on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM) sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. PMID:27418862

  15. Therapy for depression in bipolar affective disorder

    Directory of Open Access Journals (Sweden)

    N. A. Tyuvina

    2016-01-01

    Full Text Available Objective: to evaluate the efficiency and safety of different therapy regimens for depression in relation to the clinical type of bipolar affective disorders (BAD and to choose optimal treatment regimens for depression in BAD type I (BADI and BAD type II (BADII.Patients and methods. A total of 65 depressive patients, including 25 with BADI and 37 with BADII, were examined. 212 depressive episodes were analyzed in BAD patients, of them there were 74 with BADI and 138 with BADII. The patients with BADI took a combination of an antidepressant (AD and a normothymic (NT, NT and a neuroleptic (NL, AD, NT and NL. Those with BADII received monotherapy with AD or NL, a combination of AD + NT, AD + NL. The patients' status was clinically evaluated using a specially designed questionnaire and the MADRS and CGI psychometric scales at baseline and then at the end of 1, 2, 4, and 8 weeks of therapy.Results. The AD-containing regimens used to treat patients with BADI proved to be more effective; this therapy led to a more marked reduction in depressive symptoms (55.73% in the AD + NT-treated patients; 54.07% in the AD + NT + NL group versus 33.64% in the NT + NL-treated patients, a higher response to therapy, and a larger number of remissions by the end of the investigation (80.0, 72.7, and 33.3%, respectively. Moreover, the incidence of transient hypomanic symptoms did not significantly differ in these groups (20.0, 27.3, and 8.3%, respectively. The depressive patients with BADII generally responded better to different therapy regimens (the reduction in depressive symptoms was 52.08, 58.82, 58.40, and 53.98% in the AD, NL, AD + NT, and AD + NL groups; the remission index by the end of the investigation was 60.6, 92.9, 77.8, and 69.2%, respectively; these patients were seen to have less frequently symptoms of an antipole during their treatment (18.2, 7.1, 0.0, and 15.4%, respectively.Conclusion. The incorporation of AD into a therapy regimen in BAD patients

  16. Genetic determinants of white matter integrity in bipolar disorder

    OpenAIRE

    Sprooten, Emma

    2012-01-01

    Bipolar disorder is a heritable psychiatric disorder, and several of the genes associated with bipolar disorder and related psychotic disorders are involved in the development and maintenance of white matter in the brain. Patients with bipolar disorder have an increased incidence of white matter hyper-intensities, and quantitative brain imaging studies collectively indicate subtle decreases in white matter density and integrity in bipolar patients. This suggests that genetic vu...

  17. Efficacy of Electroconvulsive Therapy in Bipolar Disorder with Mixed Features

    OpenAIRE

    Miguel Palma; Berta Ferreira; Nuno Borja-Santos; Bruno Trancas; Céu Monteiro; Graça Cardoso

    2016-01-01

    BACKGROUND: The aim of this study was to investigate the effectiveness of electroconvulsive therapy (ECT) in medication-nonresponsive patients with mixed mania and bipolar depression. METHOD: Forty-one patients with mixed mania (DSM-IV diagnosis of bipolar I disorder, most recent episode mixed) and 23 patients with bipolar depression (DSM-IV diagnosis of bipolar I disorder, most recent episode depressed) consecutively assigned to ECT treatment were included in this study. Subjects we...

  18. Electrical coupling between bipolar cells in carp retina

    OpenAIRE

    Kujiraoka, Toru; Saito, Takehiko

    1986-01-01

    Intracellular recordings were made simultaneously from pairs of neighboring bipolar cells by advancing two independent microelectrodes into retinas of carp (Cyprinus carpio). Bipolar cells were identified by their response properties and in several samples were verified by intracellular injection of Lucifer yellow. Current of either polarity injected into one member of the bipolar cell pair elicited a signconserving, sustained potential change in the other bipolar cell without any significant...

  19. Rumination in bipolar disorder: evidence for an unquiet mind

    OpenAIRE

    Ghaznavi Sharmin; Deckersbach Thilo

    2012-01-01

    Abstract Depression in bipolar disorder has long been thought to be a state characterized by mental inactivity. However, recent research demonstrates that patients with bipolar disorder engage in rumination, a form of self-focused repetitive cognitive activity, in depressed as well as in manic states. While rumination has long been associated with depressed states in major depressive disorder, the finding that patients with bipolar disorder ruminate in manic states is unique to bipolar disord...

  20. Experience of Subjective Symptoms in Euthymic Patients with Bipolar Disorder

    OpenAIRE

    Joe, Soohyun; Joo,YeonHo; Kim, Seongyoon

    2008-01-01

    Bipolar patients often experience subjective symptoms even if they do not have active psychotic symptoms in their euthymic state. Most studies about subjective symptoms are conducted in schizophrenia, and there are few studies involving bipolar patients. We examined the nature of the subjective symptoms of bipolar patients in their euthymic state, and we also compared it to that of schizophrenia and normal control. Thirty bipolar patients, 25 patients with schizophrenia, and 21 normal control...

  1. A Review of MR Spectroscopy Studies of Pediatric Bipolar Disorder

    OpenAIRE

    Kondo, D.G.; Hellem, T.L.; Shi, X.-F.; Sung, Y.H.; Prescot, A.P.; Kim, T.S.; Huber, R.S.; Forrest, L.N.; Renshaw, P.F.

    2014-01-01

    Pediatric bipolar disorder is a severe mental illness whose pathophysiology is poorly understood and for which there is an urgent need for improved diagnosis and treatment. MR spectroscopy is a neuroimaging method capable of in vivo measurement of neurochemicals relevant to bipolar disorder neurobiology. MR spectroscopy studies of adult bipolar disorder provide consistent evidence for alterations in the glutamate system and mitochondrial function. In bipolar disorder, these 2 phenomena may be...

  2. The role of lamotrigine in the management of bipolar disorder

    OpenAIRE

    Ng, Felicity; Hallam, Karen; Lucas, Nellie; Berk, Michael

    2007-01-01

    Lamotrigine has emerged with a distinct place in the pharmacological treatment of bipolar disorder, with the potential to treat and prevent bipolar depression, which is the dominant and arguably most disabling and under-treated phase of the illness. This review examines the published clinical trials of lamotrigine in bipolar treatment. While the data supports its tolerability and safety, the strongest evidence for its efficacy lies in the prevention of bipolar depression, with weaker evidence...

  3. TREATMENT OF HYPOTHYROIDISM IS IMPORTANT IN TREATING BIPOLAR AFFECTIVE DISORDER

    OpenAIRE

    Sainath B Reddy; B Deepika; Harish, S

    2014-01-01

    Bipolar affective disorder along with hypothyroidism is well documented. There are few studies regarding hypothyroidism in patients with bipolar affective disorder. Here our main motto is to report such a case who was presented with bipolar affective disorder along with hypothyroidism as a co-morbidity & to provide a brief information regarding association of hypothyroidism in bipolar affective disorder. Treatment approaches in such co-morbid conditions.

  4. Immunocytochemical Evidence that Monkey Rod Bipolar Cells Use GABA

    OpenAIRE

    Lassová, Luisa; Fina, Marie; Sulaiman, Pyroja; Vard, Noga

    2010-01-01

    Certain bipolar cells in most species immunostain for GABA or its synthesizing enzyme, GAD. However it is unknown whether they actually release GABA, and if so, from which cellular compartment, and by what release mechanism. We investigated these questions in monkey retina where rod bipolar cells immunostain for GABA. We found that rod bipolar cells immunostain for one isoform of GAD, GAD65, in their somas, dendrites, and axon terminals. Near the fovea, the somatic stain of rod bipolar cells ...

  5. Extended Driving Impairs Nocturnal Driving Performances

    OpenAIRE

    Patricia Sagaspe; Jacques Taillard; Torbjorn Akerstedt; Virginie Bayon; Stéphane Espié; Guillaume Chaumet; Bernard Bioulac; Pierre Philip

    2008-01-01

    Though fatigue and sleepiness at the wheel are well-known risk factors for traffic accidents, many drivers combine extended driving and sleep deprivation. Fatigue-related accidents occur mainly at night but there is no experimental data available to determine if the duration of prior driving affects driving performance at night. Participants drove in 3 nocturnal driving sessions (3-5 am, 1-5 am and 9 pm-5 am) on open highway. Fourteen young healthy men (mean age [+/-SD] = 23.4 [+/-1.7] years)...

  6. Extended Driving Impairs Nocturnal Driving Performances

    OpenAIRE

    SAGASPE, Patricia; Taillard, Jacques; Åkerstedt, Torbjorn; BAYON, Virginie; Espié, Stéphane; Chaumet, Guillaume; Bioulac, Bernard; Philip, Pierre

    2008-01-01

    Though fatigue and sleepiness at the wheel are well-known risk factors for traffic accidents, many drivers combine extended driving and sleep deprivation. Fatigue-related accidents occur mainly at night but there is no experimental data available to determine if the duration of prior driving affects driving performance at night. Participants drove in 3 nocturnal driving sessions (3–5am, 1–5am and 9pm–5am) on open highway. Fourteen young healthy men (mean age [±SD] = 23.4 [±1.7] years) partici...

  7. Reading Text While Driving

    OpenAIRE

    Liang, Yulan; Horrey, William J.; Hoffman, Joshua D.

    2015-01-01

    Objective In this study, we investigated how drivers adapt secondary-task initiation and time-sharing behavior when faced with fluctuating driving demands. Background Reading text while driving is particularly detrimental; however, in real-world driving, drivers actively decide when to perform the task. Method In a test track experiment, participants were free to decide when to read messages while driving along a straight road consisting of an area with increased driving demands (demand zone)...

  8. HARMONIC DRIVE SELECTION

    Directory of Open Access Journals (Sweden)

    Piotr FOLĘGA

    2014-03-01

    Full Text Available The variety of types and sizes currently in production harmonic drive is a problem in their rational choice. Properly selected harmonic drive must meet certain requirements during operation, and achieve the anticipated service life. The paper discusses the problems associated with the selection of the harmonic drive. It also presents the algorithm correct choice of harmonic drive. The main objective of this study was to develop a computer program that allows the correct choice of harmonic drive by developed algorithm.

  9. Family Functioning and the Course of Adolescent Bipolar Disorder

    Science.gov (United States)

    Sullivan, Aimee E.; Judd, Charles M.; Axelson, David A.; Miklowitz, David J.

    2012-01-01

    The symptoms of bipolar disorder affect and are affected by the functioning of family environments. Little is known, however, about the stability of family functioning among youth with bipolar disorder as they cycle in and out of mood episodes. This study examined family functioning and its relationship to symptoms of adolescent bipolar disorder,…

  10. Review of Evidence for Use of Antidepressants in Bipolar Depression

    OpenAIRE

    McInerney, Shane J.; Kennedy, Sidney H.

    2014-01-01

    Objective: Depressive episodes predominate over the course of bipolar disorder and cause considerable functional impairment. Antidepressants are frequently prescribed in the treatment of bipolar depression, despite concerns about efficacy and risk of switching to mania. This review provides a critical examination of the evidence for and against the use of antidepressants in bipolar depression.

  11. Plain carbon steel bipolar plates for PEMFC

    Institute of Scientific and Technical Information of China (English)

    WANG Jianli; SUN Juncai; TIAN Rujin; XU Jing

    2006-01-01

    Bipolar plates are a multifunctional component of PEMFC. Comparing with the machined graphite and stainless steels, the plain carbon steel is a very cheap commercial metal material. In this paper, the possibility of applying the plain carbon steels in the bipolar plate for PEMFC was exploited. In order to improve the corrosion resistance of the low carbon steel in the PEMFCs' environments,two surface modification processes was developed and then the electrochemical performances and interfacial contact resistance (ICR) of the surface modified plate of plain carbon steel were investigated. The results show that the surface modified steel plates have good corrosion resistance and relatively low contact resistance, and it may be a candidate material as bipolar plate of PEMFC.

  12. A nickel-hydrogen bipolar secondary battery

    Science.gov (United States)

    Chireau, R. F.; Berchielli, A. S.

    A study was conducted to test the concept of using bipolar nickel-hydrogen batteries for an energy storage system that would be compatible with both existing and future electrical generation and distribution equipment. The feasibility of a bipolar nickel-hydrogen rechargeable system was investigated with respect to performance characteristics such as charge acceptance, overcharge capability, cell reversal capability, electrolyte management, and cycle life. Peak specific power figures of over 350 W per kilogram were achieved and the specific energy of the bipolar battery was 60 W-hr/kg at the 3 hr rate of discharge. It was concluded that the new energy storage system would be suitable for load-leveling applications.

  13. Kadınlarda Bipolar Bozukluk

    OpenAIRE

    Sermin Kesebir; Leman Inanc; Cigdem Hazal Bezgin; Fatma Cengiz

    2013-01-01

    Bipolar bozuklukta cinsiyetin etkisini araştıran çalışmalar son yıllarda giderek artmaktadır. Karma atak ve disforik durumlar, depresif atak, hızlı döngülülük, mevsimsel gidiş, hipotiroidi, migren ve obezite başta olmak üzere bedensel hastalık eştanısı bipolar bozukluğu olan kadınlarda erkeklerden daha sık görülmektedir. Alkol ve madde kullanım bozukluğu eş tanısı erkek bipolar bozukluk olgularında daha sık olmakla birlikte, kadınlarda alkol ve madde kullanım bozukluğu geliştirme riski, erkek...

  14. Processamento cognitivo "Teoria da Mente" no transtorno bipolar Cognitive "Theory of Mind" processing in bipolar disorder

    OpenAIRE

    Hélio Anderson Tonelli

    2009-01-01

    OBJETIVO: O transtorno afetivo bipolar está associado ao comprometimento funcional persistente. Apesar de muitas pesquisas demonstrarem que bipolares podem apresentar déficits cognitivos, um número menor de trabalhos avaliou o papel de prejuízos no processamento cognitivo social, a Teoria da Mente (relacionado à capacidade de inferir estados mentais), no aparecimento de sintomas e complicações sociais em bipolares. O objetivo deste trabalho é o de revisar sistemática e criticamente a literatu...

  15. Transtorno bipolar do humor e gênero Bipolar affective disorder and gender

    OpenAIRE

    Rodrigo da Silva Dias; Florence Kerr-Corrêa; Ricardo Cezar Torresan; Carlos Henrique R. dos Santos

    2006-01-01

    Embora o transtorno bipolar (TB) ocorra quase igualmente em ambos os sexos, a fenomenologia e o curso da doença diferem no homem e na mulher. No entanto, há evidências de que mulheres bipolares, mais que os homens, apresentariam início mais tardio (em especial na quinta década de vida), ciclagem rápida, mais episódios depressivos, mais mania disfórica que eufórica, estados mistos e evolução do tipo bipolar II, ainda que os achados nem sempre sejam consistentes. Embora o risco de comorbidades ...

  16. Laser ohjattava led-matriisi

    OpenAIRE

    Harri, Jarkko

    2011-01-01

    Työn alkuperäisenä tavoitteena oli kehittää näyttävä led matriisitaulu, jolla voi myös näyttää kuvia tietokoneen avulla. Matriisitaulua suunnitellessa tuli esiin toive isosta taulusta, jota voisi käyttää mainoksena, voisi piirtää laserosoittimen avulla kuvioita ja sen tulisi soveltua ulkokäyttöön. Matriisitaulu toteutettiin modulaarisena, joka mahdollistaa erikokoisien taulujen rakentamisen helposti. Valon kirkkauden tunnistamiseen käytetään matriisin ledejä. Yhden moduulin suurin tehonkulutu...

  17. LED-ajoneuvovalojen testauslaitteiston suunnittelu

    OpenAIRE

    Moilanen, Vitali

    2013-01-01

    Tässä työssä laajennettiin valmiina olevaa LED-ajovalojen testauslaitteistoa suunnittelemalla uusi käyttöliittymä ja lisäämällä uusia hyödyllisiä ominaisuuksia. Laitteeseen on lisätty tulosten esittelyä ja tarkastelua varten pieni 2-rivinen nestekidenäyttö ja USB:n avulla toteutettu yhteys tietokoneen kanssa. Lisäksi oli suunniteltu tietokoneohjelma Microsoft Visual Basicilla. Ohjelma on tarkoitettu laitteen hallintaan. Testauslaitteen ytimenä toimii Atmelin atMega48PA-mikro-ohjain ja s...

  18. Luokkahuoneen valaistus LED-tekniikalla

    OpenAIRE

    Malassu, Henri

    2013-01-01

    Tämä insinöörityö käsittää Kiinteistö Oy Mäkelän koulun luokkahuoneiden valaistus-selvityksen, jossa tutkittiin, löytyykö markkinoilta energiatehokkaita LED-valaisimia tai valonlähteitä vaihtoehdoiksi luokkahuoneen nykyisille T8-loisteputkivalaisimille. Uuden vaihtoehtoisen valaisimen tai valonlähteen tulisi olla energiatehokkaampi, mutta valaistuksen laadun tulisi kuitenkin pysyä vähintäänkin samana. Työ tehtiin Insinööritoimisto Leo Maaskola Oy:n tilauksesta. Aluksi selvitettiin markkin...

  19. LED-valaistuksen suunnittelu LEKOhalliin

    OpenAIRE

    Alanko, Lauri

    2014-01-01

    Opinnäytetyön tavoitteena oli selvittää, kannattaako nykyinen valaistus LEKOhalleissa vaihtaa LED-valaistukseen, ottaen huomioon sekä taloudellinen että valaistustekninen puoli. Tämän opinnäytetyön tarkoitus on toimia apuna, kun suunnitellaan valaistuksen uudistamista LEKOhalleihin. Opinnäytetyön tekemiselle oli monia syitä, joista yksi oli LEDien nopea kehitys viime vuosina. Lisäksi käyttäjien tyytymättömyys nykyiseen valaistukseen ja mahdollisten säästöjen saaminen olivat painavia syitä opi...

  20. [Bipolar disorders and self-stigma].

    Science.gov (United States)

    Richard-Lepouriel, H

    2015-09-16

    Despite wide media coverage in recent years, the stigmatization of people with bipolar disorder still exists. Bipolar people also have their own tendency to self-stigmatize that is to integrate their beliefs, prejudices and stigmatizing behaviors. The consequences are important: shame, guilt, withdrawal and renunciation to lead one's own life according to personal values increasing therefore the risk of mood relapses. Self-stigma is rarely assessed in clinical practice and few strategies have been designed to face them efficiently. Recognizing self-stigmatizing beliefs and challenging them are the first steps of this vast endeavour. PMID:26591079

  1. Rumination in bipolar disorder: a systematic review

    OpenAIRE

    Érico de M. Silveira Jr.; Marcia Kauer-Sant'Anna

    2015-01-01

    Objective:To conduct a systematic review of the literature about the symptom of rumination in bipolar disorder (BD).Methods:We searched the MEDLINE (PubMed), ISI Web of Knowledge, PsycINFO, and SciELO databases using the descriptors “rumination” and “bipolar disorder” and no time limits. This strategy yielded 105 references, of which 74 were selected. Inclusion criteria were studies involving patients with BD and the use of at least one validated scale for the assessment of rumination. Review...

  2. Low Cost Heart Rate Monitor Using Led-Led Sensor

    Directory of Open Access Journals (Sweden)

    Ahmed Mahrous Ragib

    2009-01-01

    Full Text Available A high sensitivity, low power and low cost sensor has been developed for photoplethysmography (PPG measurement. The PPG principle was applied to follow the dilatation and contraction of skin blood vessels during the cardiac cycle. A standard light emitting diodes (LEDs has been used as a light emitter and detector, and in order to reduce the space, cost and power, the classical analogue-to-digital converters (ADCs replaced by the pulse-based signal conversion techniques. A general purpose microcontroller has been used for the implementation of measurement protocol. The proposed approach leads to better spectral sensitivity, increased resolution, reduction in cost, dimensions and power consumption. The basic sensing configuration presented is capable of detecting the PPG signal from a finger or toe, and it is very simple to extract the heart rate and heart rate variability from such a signal.

  3. A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force

    DEFF Research Database (Denmark)

    Sajatovic, Martha; Strejilevich, Sergio A; Gildengers, Ariel G;

    2015-01-01

    OBJECTIVES: In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD). METHODS...

  4. Generation of short electrical pulses based on bipolar transistorsny

    Directory of Open Access Journals (Sweden)

    M. Gerding

    2004-01-01

    Full Text Available A system for the generation of short electrical pulses based on the minority carrier charge storage and the step recovery effect of bipolar transistors is presented. Electrical pulses of about 90 ps up to 800 ps duration are generated with a maximum amplitude of approximately 7V at 50Ω. The bipolar transistor is driven into saturation and the base-collector and base-emitter junctions become forward biased. The resulting fast switch-off edge of the transistor’s output signal is the basis for the pulse generation. The fast switching of the transistor occurs as a result of the minority carriers that have been injected and stored across the base-collector junction under forward bias conditions. If the saturated transistor is suddenly reverse biased the pn-junction will appear as a low impedance until the stored charge is depleted. Then the impedance will suddenly increase to its normal high value and the flow of current through the junction will turn to zero, abruptly. A differentiation of the output signal of the transistor results in two short pulses with opposite polarities. The differentiating circuit is implemented by a transmission line network, which mainly acts as a high pass filter. Both the transistor technology (pnp or npn and the phase of the transfer function of the differentating circuit influence the polarity of the output pulses. The pulse duration depends on the transistor parameters as well as on the transfer function of the pulse shaping network. This way of generating short electrical pulses is a new alternative for conventional comb generators based on steprecovery diodes (SRD. Due to the three-terminal structure of the transistor the isolation problem between the input and the output signal of the transistor network is drastically simplified. Furthermore the transistor is an active element in contrast to a SRD, so that its current gain can be used to minimize the power of the driving signal.

  5. Unipolar and bipolar fatigue in antiferroelectric lead zirconate thin films and evidences for switching-induced charge injection inducing fatigue

    OpenAIRE

    Lou, X. J.; Wang, J.

    2010-01-01

    For the first time, we show that unipolar fatigue does occur in antiferroelectric capacitors, confirming the predictions of a previous work [Appl. Phys. Lett., 94, 072901 (2009)]. We also show that unipolar fatigue in antiferroelectrics is less severe than bipolar fatigue if the driving field is of the same magnitude. This phenomenon has been attributed to the switching-induced charge injection, the main cause for polarization fatigue in ferroelectric and antiferroelectric materials. Other ev...

  6. Sleep disturbances in pediatric bipolar disorder: A comparison between Bipolar I and Bipolar NOS

    Directory of Open Access Journals (Sweden)

    ArgelindaBaroni

    2012-03-01

    Full Text Available Introduction: The diagnosis of Bipolar Disorder (BD in youths has been controversial, especially for the subtype BD Not Otherwise Specified (BD-NOS. In spite of growing evidence that sleep is a core feature of BD, few studies characterize and compare sleep disturbances in youth with BD type I (BD-I and BD-NOS. Sleep disturbances are frequently reported in clinical descriptions of children and adolescents with BD, however the reporting of the frequency and characteristics of sleep symptoms in youth with BD NOS and BD I during episodes remain poor. This study compares symptom of sleep disturbance as occurring in manic and depressive episodes in BD I and BD NOS youth using KSADS-PL interview data. The study also addresses whether symptoms of sleep disturbance vary in different age groups. Material and Methods: The sample consisted of 70 children and adolescent outpatients at an urban specialty clinic (42M/28F, 10.8±3.6 years old including 24 BP-I and 46 BP-NOS assessed using K-SADS-PL-parent interview. Results: Sleep disturbances including insomnia and decreased need for sleep were reported by 84.3% of the sample. Enuresis was diagnosed in 27% of sample. There were no significant differences in frequency of sleep symptoms between BD-I and BD-NOS. Regardless of BD subtype, current functioning was negatively correlated with decreased need for sleep but not insomnia, and regardless of BD subtype. Conclusion: The majority of youth with BD presents with sleep symptoms during mood episodes. BD NOS presents with the same proportion of sleep symptoms as BD I in our sample.

  7. Clinical variables and implications of the personality on the outcome of bipolar illness: a pilot study

    OpenAIRE

    Casas-Barquero, Nieves; García-López, Olga; Fernández-Argüelles, Pedro; Camacho-Laraña, Manuel

    2007-01-01

    Outcome in bipolar patients is affected by comorbidity. Comorbid personality disorders are frequent and may complicate the course of bipolar illness. This pilot study examined a series of 40 euthymic bipolar patients (DSM-IV criteria) (bipolar I disorder 31, bipolar II disorder 9) to assess the effect of clinical variables and the influence of comorbid personality on the clinical course of bipolar illness. Bipolar patients with a diagnosis of comorbid personality disorder (n = 30) were compar...

  8. BIPOLAR DISORDER AND METABOLIC SYNDROME: COMORBIDITY OR SIDE EFFECTS OF TREATMENT OF BIPOLAR DISORDER

    OpenAIRE

    Babić, Dragan; Maslov, Boris; Nikolić, Katica; Martinac, Marko; Uzun, Suzana; Kozumplik, Oliver

    2010-01-01

    Objective: There is evidence that people with mental disorders are more likely to suffer from metabolic syndrome. In the last decades there has been an increase in interest for researching metabolic syndrome in psychiatric patients and plenty of evidence about their association. However, investigations on the prevalence of metabolic syndrome in patients with bipolar disorder are still surprisingly rare. The aim of this paper is to analyze comorbidity of bipolar disorder and metabolic syndrome...

  9. Commentary on N. Ghaemi's “Hippocratic Psychopharmacology of Bipolar Disorder” Maintenance Treatment in Bipolar Disorder

    OpenAIRE

    Tohen, Mauricio; Lin, Daniel

    2006-01-01

    Bipolar disorder is a chronic recurring condition that is associated with high mortality and severe functional and psychosocial impairments. Treatment strategies that prolong recovery from a mood episode and delay relapse into a new mood episode are essential for long-term improvements in outcomes. Maintenance treatments for bipolar disorder should be evaluated on the strength of the empirical evidence and with the recognition that some treatments may be more effective in preventing relapse i...

  10. Alteración del funcionamiento familiar en el trastorno bipolar Family disruption in bipolar disorder

    OpenAIRE

    Dagmar Holmgren G; Víctor Lermanda S.; Clara Cortés V.; Isabel Cárdenas M.; Karen Aguirre A.; Karem Valenzuela A.

    2005-01-01

    En el curso de los últimos años se ha acumulado abundante evidencia sobre el beneficio de las intervenciones psicosociales en el tratamiento integral del trastorno bipolar. La psicoeducación a pacientes y familiares ha sido reportada por distintos grupos como un medio de reforzar la adherencia al tratamiento. En familias de pacientes bipolares se han descrito alteraciones en el funcionamiento psicosocial intrafamiliar. Nuestro servicio ha desarrollado un programa psicoeducativo aplicando el m...

  11. Thixoforming A356 Aluminum Bipolar Plates at High Solid Fractions

    Science.gov (United States)

    Bolouri, Amir; Jang, Chang Hyun; Kang, Chung Gil

    2014-04-01

    Thixoforming investigations have been developed primarily for the manufacturing of bulk components, and the current knowledge is very limited with respect to the fabrication of thin cross sections of alloys. We studied the effectiveness of thixoforming process for the fabrication of A356 aluminum alloy bipolar plates with microchannels on both sides. Feedstock semisolid slurries, with different solid contents of ~55, 50, and 45 pct, were prepared at 858 K, 863 K, and 868 K (585 °C, 590 °C, and 595 °C), respectively, and were used to thixoform 1.20-mm-thick bipolar thin plates. The microstructures of the thixoformed thin plates consisted of (i) large primary α-Al globular grains, (ii) a quenched liquid phase, and (iii) fine secondary α-Al particles. The fraction and size of the primary α-Al globular grains decreased, and the primary α-Al globular grains became more spherical with the increasing thixoforming temperature. It seemed that these changes in the microstructural features led to the reduction in the agglomeration and interaction among the primary α-Al globular grains surrounded by the liquid matrix during thixoforming. This enabled the semisolid slurry to effectively flow and fill in the sharp corners (such as the microchannels) of the die cavity at higher thixoforming temperatures. The thin plates thixoformed at 868 K (595 °C), consequently, exhibited the highest dimensional stability and the fewest internal defects. The liquid matrix surrounding the primary α-Al grains solidified inside the die cavity after thixoforming. Either the liquid phase was instantly quenched or fine secondary α-Al particles were formed inside the die cavity. The fraction and size of the latter increased with increasing thixoforming temperature. The surface hardness of the thixoformed plates was measured, and the hardness values were correlated with the microstructural features of the thixoformed plates.

  12. Developing Successful International Faculty Led Program

    Science.gov (United States)

    Fabregas Janeiro, Maria G.; Fabre, Ricardo Lopez; Rosete, Rodrigo Tello

    2012-01-01

    Faculty Led Programs are study abroad experiences led by university professors. Faculty Led Programs are considered as an opportunity for college students, especially in the United States to attend a short-term international experience (Mills, 2010). Faculty Led Program is an international experience which is different from the traditional…

  13. Practical lighting design with LEDs

    CERN Document Server

    Lenk, Ron

    2011-01-01

    "This book covers all of the information needed to design LEDs into end-products. It is a practical guide, primarily explaning how things are done by practicing engineers. Equations are used only for practical calculations, and are kept to the level of high-school algebra. There are numerous drawings and schematics showing how things such as measurements are actually made, and showing curcuits that actually work. There are practical notes and examples embedded in the text that give pointers and how-to guides on many of the book's topics. After reading each chapter of the book, readers will have the knowledge to implement practical designs. This book will be kept as a reference tool for years to come"--

  14. [Psychotherapeutic interventions in bipolar disorder: a review].

    Science.gov (United States)

    Hausmann, Armand; Hörtnagl, Christine; Müller, Markus; Waack, Julie; Walpath, Michaela; Conca, Andreas

    2007-01-01

    The treatment of bipolar disorders is a demanding task involving patients, therapists and relatives. As bipolar disorders are associated to multiple psychosocial disturbances, the management of a bipolar disease should focus on psychosocial interventions. Despite an exploding literature on this topic, psychopharmacological interventions applied as a monotherapy have shown unsatisfactory outcomes. In order to enhance outcome, psychotherapy, such as cognitive behavioural therapy (CBT), psychoeducation, a modified form of interpersonal psychotherapy (IPSRT) or family focussed psychotherapy (FFT) were investigated. When used in conjunction with pharmacotherapy, these interventions may prolong time to relapse, reduce symptom severity, and increase medication adherence. These combinations are currently considered being the golden standard in the treatment of bipolar disorders. Psychotherapeutic interventions as an add-on strategy exert better effects when patients are euthymic at entry. Prevention of manic episodes seems to be more successful as compared to the prevention of depressive episodes. There are currently no hints for a method specific efficacy. Efficacy of psychoeducation seems to be rather short lived. Currently not yet evaluated booster-sessions might help. More data are needed in order to identify patients with a putative good response to psychotherapeutic interventions. PMID:17640496

  15. Bipolar disorder: from genes to behavior pathways

    OpenAIRE

    Martinowich, Keri; Schloesser, Robert J; Manji, Husseini K

    2009-01-01

    Bipolar disorder (BPD) is a devastating illness that is characterized by recurrent episodes of mania and depression. In addition to these cyclic episodes, individuals with BPD exhibit changes in psychovegetative function, cognitive performance, and general health and well being. In this article we draw from neuroimaging findings in humans, postmortem data, and human genetic and pharmacological studies as well as ...

  16. Electrostatic Changes Observed with Narrow Bipolar Pulses

    Science.gov (United States)

    Karunarathne, S.; Marshall, T. C.; Stolzenburg, M.; Karunarathna, N.

    2015-12-01

    Narrow bipolar pulses (NBPs) or compact intracloud discharges are impulsive discharges that are considered to be the strongest natural emitters in the HF radio band; they usually occur at high altitudes in some thunderstorms. In the summer of 2011, we collected E-change data with wideband flat-plate antennas (0.16 Hz - 2.5 MHz) at ten stations covering an area of nearly 70 km x 100 km in and around Kennedy Space Center, Florida, USA. On one thunderstorm day, 14 August 2011, we detected 226 positive NBPs, and some observations of these pulses were published in Karunarathne et al. [2015, JGR-atmospheres]. Of these 226 NBPs, 50 (22.1 %) occurred within 10 km horizontally of at least one sensor. All of these closer sensors show electrostatic changes associated with corresponding NBPs, with a net electrostatic change in the main bipolar pulse and with a slower electrostatic change after the bipolar pulse that seems similar to short continuing current immediately after some cloud-to-ground return strokes. Although NBPs have been considered as short duration pulses (10 - 20 microseconds), the electrostatic changes after the main bipolar pulse ranged from 0.7 ms to 34 ms and associated charge moments were calculated. The total duration of the electrostatic E-change was strongly dependent on the distance to the sensors. In this presentation, we will present data for these electrostatic changes, some statistics, and physical background and reasoning for the electrostatic changes.

  17. Bipolar disorder: Evidence for a major locus

    Energy Technology Data Exchange (ETDEWEB)

    Spence, M.A.; Flodman, P.L. [Univ. of California, Irvine, CA (United States); Sadovnick, A.D.; Ameli, H. [Univ. of British Columbia, Vancouver (Canada)] [and others

    1995-10-09

    Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of inheritance. The probands were ascertained from consecutive referrals to the Mood Disorder Service, University Hospital, University of British Columbia and diagnosed by DSM-III-R and Research Diagnostic Criteria. Data were available on over 1,500 first-degree relatives of the 186 Caucasian probands. The purpose of the analyses was to determine if, after correcting for age and birth cohort, there was evidence for a single major locus. Five models were fit to the data using the statistical package SAGE: (1) dominant, (2) recessive, (3) arbitrary mendelian inheritance, (4) environmental, and (5) no major effects. A single dominant, mendelian major locus was the best fitting of these models for the sample of bipolar I and II probands when only bipolar relatives were defined as affected (polygenic inheritance could not be tested). Adding recurrent major depression to the diagnosis {open_quotes}affected{close_quotes} for relatives reduced the evidence for a major locus effect. Our findings support the undertaking of linkage studies and are consistent with the analyses of the National Institutes of Mental Health (NIMH) Collaborative Study data by Rice et al. and Blangero and Elston. 39 refs., 4 tabs.

  18. Homocysteine and cognitive functions in bipolar depression

    Directory of Open Access Journals (Sweden)

    Agnieszka Permoda-Osip

    2014-12-01

    The results obtained show higher HCY concentration in considerable proportion of patients with bipolar depression, especially in men. They also confirm a connect between high homocysteine concentration and worse performance in some neuropsychological tests. Such relationship was more marked in men.

  19. Climatic factors and bipolar affective disorder

    DEFF Research Database (Denmark)

    Christensen, Ellen Margrethe; Larsen, Jens Knud; Gjerris, Annette;

    2008-01-01

    group of patients with at least three previous hospitalizations for bipolar disorder was examined every 3 months for up to 3 years. At each examination an evaluation of the affective phase was made according to the Hamilton Depression Scale (HAM-D(17)), and the Bech-Rafaelsen Mania Rating Scale (MAS...

  20. Udvikling af medicinsk behandling mod bipolar lidelse

    DEFF Research Database (Denmark)

    Ellegaard, Pernille Kempel

    2015-01-01

    Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase....

  1. Bipolar high voltage pulse power generator

    Czech Academy of Sciences Publication Activity Database

    Lukeš, Petr; Člupek, Martin; Babický, Václav; Šunka, Pavel

    Monterey, 2005, s. 44. [IEEE International Pulsed Power Conference/15th./. Portola Plaza Hotel, Monterey, CA, USA (US), 13.06.2005-17.06.2005] R&D Projects: GA AV ČR KSK2043105 Keywords : bipolar * pulse power generator * corona discharge Subject RIV: BL - Plasma and Gas Discharge Physics

  2. Does the X-chromosome carry the gene responsible for bipolar disorder? An offspring with bipolar disorder and coexisting muscular dystrophy from a mother with bipolar disorder

    OpenAIRE

    tuba gokdogan edgunlu; ibrahim duvarci; esin sakali cetin

    2013-01-01

    According to family, twin and adoption studies, which consistently indicate a strong genetic component, the specific genes that are responsible for bipolar disorder remain unclear. While the mode of transmission is poorly characterized, genetic studies suggest that the X-chromosome may be responsible for bipolar disorder. Muscular dystrophy is an X-chromosome linked recessively inherited disorder. In this case, we present a 35 year-old male with bipolar disorder and coexisting muscular dystro...

  3. Dementia and driving

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000028.htm Dementia and driving To use the sharing features on ... please enable JavaScript. If your loved one has dementia, deciding when they can no longer drive may ...

  4. Implementation of PIC Based LED Displays

    OpenAIRE

    Htet Htet Thit San; Chaw Myat Nwe; Hla Myo Tun

    2014-01-01

    This paper explains the project which is a special kind of LED Display Board for performing dance movement according to the rhythm of music. Nowadays, LED display boards are widely used in advertising and other applications. LED display boards can also be used indoors or outdoors. The objective of this system is to design a display panel by using several dozens of LED matrix display. The display pattern can desire to be changed easily and modified by the user. This LED display...

  5. Toward a Valid Animal Model of Bipolar Disorder: How the Research Domain Criteria Help Bridge the Clinical-Basic Science Divide.

    Science.gov (United States)

    Cosgrove, Victoria E; Kelsoe, John R; Suppes, Trisha

    2016-01-01

    Bipolar disorder is a diagnostically heterogeneous disorder, although mania emerges as a distinct phenotype characterized by elevated mood and increased activity or energy. While bipolar disorder's cyclicity is difficult to represent in animals, models of mania have begun to decode its fundamental underlying neurobiology. When psychostimulants such as amphetamine or cocaine are administered to rodents, a resulting upsurge of motor activity is thought to share face and predictive validity with mania in humans. Studying black Swiss mice, which inherently exhibit proclivity for reward seeking and risk taking, also has yielded some insight. Further, translating the biology of bipolar disorder in humans into animal models has led to greater understanding of roles for candidate biological systems such as the GRIK2 and CLOCK genes, as well as the extracellular signal-related kinase pathway involved in the pathophysiology of the illness. The National Institute of Mental Health Research Domain Criteria initiative seeks to identify building blocks of complex illnesses like bipolar disorder in hopes of uncovering the neurobiology of each, as well as how each fits together to produce syndromes like bipolar disorder or why so many mental illnesses co-occur together. Research Domain Criteria-driven preclinical models of isolated behaviors and domains involved in mania and bipolar disorder will ultimately inform movement toward nosology supported by neurobiology. PMID:26531027

  6. Gear bearing drive

    Science.gov (United States)

    Weinberg, Brian (Inventor); Mavroidis, Constantinos (Inventor); Vranish, John M. (Inventor)

    2011-01-01

    A gear bearing drive provides a compact mechanism that operates as an actuator providing torque and as a joint providing support. The drive includes a gear arrangement integrating an external rotor DC motor within a sun gear. Locking surfaces maintain the components of the drive in alignment and provide support for axial loads and moments. The gear bearing drive has a variety of applications, including as a joint in robotic arms and prosthetic limbs.

  7. Universal drive unit

    OpenAIRE

    Sehnálek, Lubomír

    2011-01-01

    This document deal with design of universal driving unit. For the final solution is required driving unit which will be controled with help of sensory unit placed on the chassis of driving unit. In theoretical part of this labour are examined possibilities of a power, electric motor operation by PWM, kind of chassis and odometry which could be taken into account. From this section is finally chosen concrete configuration which is then described in chapter concerned oneself with driving unit d...

  8. Unmet needs of bipolar disorder patients

    Directory of Open Access Journals (Sweden)

    Hajda M

    2016-06-01

    Full Text Available Miroslav Hajda,1 Jan Prasko,1 Klara Latalova,1 Radovan Hruby,2 Marie Ociskova,1 Michaela Holubova,1,3 Dana Kamaradova,1 Barbora Mainerova1 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic; 2Outpatient Psychiatric Department, Martin, Slovak Republic; 3Department of Psychiatry, Regional Hospital Liberec, Liberec, Czech Republic Background: Bipolar disorder (BD is a serious mental illness with adverse impact on the lives of the patients and their caregivers. BD is associated with many limitations in personal and interpersonal functioning and restricts the patients’ ability to use their potential capabilities fully. Bipolar patients long to live meaningful lives, but this goal is hard to achieve for those with poor insight. With progress and humanization of society, the issue of patients’ needs became an important topic. The objective of the paper is to provide the up-to-date data on the unmet needs of BD patients and their caregivers. Methods: A systematic computerized examination of MEDLINE publications from 1970 to 2015, via the keywords “bipolar disorder”, “mania”, “bipolar depression”, and “unmet needs”, was performed. Results: Patients’ needs may differ in various stages of the disorder and may have different origin and goals. Thus, we divided them into five groups relating to their nature: those connected with symptoms, treatment, quality of life, family, and pharmacotherapy. We suggested several implications of these needs for pharmacotherapy and psychotherapy. Conclusion: Trying to follow patients’ needs may be a crucial point in the treatment of BD patients. However, many needs remain unmet due to both medical and social factors. Keywords: bipolar disorder, unmet needs, stigma, treatment, medication, quality of life, family, psychotherapy

  9. Bipolar disorder with comorbid anxiety disorders: impact of comorbidity on treatment outcome in cognitive-behavioral therapy and psychoeducation

    OpenAIRE

    Hawke, Lisa D; Velyvis, Vytas; Parikh, Sagar V.

    2013-01-01

    Background Comorbid anxiety disorders are extremely prevalent in bipolar disorder (BD) and have substantial impact on the course of illness. Limited evidence regarding treatment factors has led to a renewal of research efforts examining both the impact of treatments on comorbid anxiety and the impact of comorbid anxiety on treatments. The current study examines the impact of comorbid anxiety disorders on response to two psychosocial interventions for BD. Methods A sample of 204 patients with ...

  10. Bipolar Molecular Outflows from High-Mass Protostars

    Science.gov (United States)

    Su, Yu-Nung; Zhang, Qizhou; Lim, Jeremy

    2004-03-01

    We report observations of the bipolar molecular outflows associated with the luminous (~2×104 Lsolar) far-IR sources IRAS 21519+5613 and IRAS 22506+5944, as well the dust and molecular gas condensations on which these outflows appear to be centered. The observations were made in 12CO, 13CO, C18O, and continuum at 3 mm with the BIMA array and in 12CO and 13CO with the NRAO 12 m telescope to recover extended emission filtered out by the interferometric array. We find that the outflow associated with each IRAS source shows a clear bipolar morphology in 12CO, with properties (i.e., total mass of order 10-100 Msolar, mass-outflow rate >~10-3 Msolar, dynamical timescale 104-105 yr, and energetics) comparable with those of other massive outflows associated with luminous young stellar objects. Each outflow appears to be centered on a dust and gas condensation with a mass of 200-300 Msolar, likely marking the location of the driving source. The outflow lobes of both sources are fully resolved along their major but not minor axes, and they have collimation factors that may be comparable with young low-mass stars. The mass-velocity diagrams of both outflows change in slope at a velocity of ~10 km s-1, suggesting that the high-velocity component (HVC) may drive the low-velocity component (LVC). Although the HVC of IRAS 21519+5613 shows evidence for deceleration, no such signature is seen in the HVC of IRAS 22506+5944. Neither HVC has a momentum supply rate sufficient to drive their corresponding LVCs, although it is possible that the HVC is more highly excited and hence its thrust underestimated. Like for other molecular outflows the primary driving agent cannot be ionized gas, leaving atomic gas as the other remaining candidate. Neither IRAS 21519+5613 nor IRAS 22506+5944 exhibits detectable free-free emission, which together with the observed properties of their molecular outflows and surrounding condensations make them credible candidates for high-mass protostars. The mass

  11. 中国LED 照明産業の推移と現状

    OpenAIRE

    石田,のり子; 田中,武

    2014-01-01

    LED lighting industry into the new phase in 2013. Unfortunately, has become a driving force are the earthquake and Fukushima nuclear power plant disaster in Japan. The spread of LED lights advanced ahead of the world. So, Japan became the LED light developed country. Put to the coexisting market with OLED Lighting industrial in 2013. On the other hand, the LED light diffusion rate became 3-4% on the basis of amount in China in 2012. In China, Outdoor markets particularly expanded thanks to...

  12. Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers.

    Science.gov (United States)

    Scholey, Jessica E; Nithianantham, Stanley; Scholey, Jonathan M; Al-Bassam, Jawdat

    2014-01-01

    Chromosome segregation during mitosis depends upon Kinesin-5 motors, which display a conserved, bipolar homotetrameric organization consisting of two motor dimers at opposite ends of a central rod. Kinesin-5 motors crosslink adjacent microtubules to drive or constrain their sliding apart, but the structural basis of their organization is unknown. In this study, we report the atomic structure of the bipolar assembly (BASS) domain that directs four Kinesin-5 subunits to form a bipolar minifilament. BASS is a novel 26-nm four-helix bundle, consisting of two anti-parallel coiled-coils at its center, stabilized by alternating hydrophobic and ionic four-helical interfaces, which based on mutagenesis experiments, are critical for tetramerization. Strikingly, N-terminal BASS helices bend as they emerge from the central bundle, swapping partner helices, to form dimeric parallel coiled-coils at both ends, which are offset by 90°. We propose that BASS is a mechanically stable, plectonemically-coiled junction, transmitting forces between Kinesin-5 motor dimers during microtubule sliding. DOI: http://dx.doi.org/10.7554/eLife.02217.001. PMID:24714498

  13. LEDs light up the world

    Energy Technology Data Exchange (ETDEWEB)

    Mather, N.

    2004-06-30

    A lighting system using light-emitting diodes, and privately financed by a Canadian engineering professor at the University of Calgary, has been set up in a village in Nepal in 2000. Since then, through the efforts of the 'Light Up The World' Foundation, established by Dr. Irvine-Halliday, projects have lit up thousands of homes in the Philippines, India, Afghanistan, the Galapagos Islands, Mexico, Sri Lanka, and Angola. Although the goal of the project is primarily to provide lighting for reading and writing for school-children, the project has been the source of many other advantages; creation of enterprise, increased employment, enhanced income, gender equality, and improvements in health and safety among them. Since LED lamps in most cases replace kerosene lamps, the system also has significant environmental benefits. The system as originally envisioned creates electricity by pedal-powered generator, or by solar panels connected to a battery, depending on what is available at each home. Each home is connected to the power supply and supplied with low-energy diode lamps. The lights are extremely efficient and many homes can be equipped with them using less energy than it takes to power a single 100-watt light bulb. 5 photos.

  14. High performance AC drives

    CERN Document Server

    Ahmad, Mukhtar

    2010-01-01

    This book presents a comprehensive view of high performance ac drives. It may be considered as both a text book for graduate students and as an up-to-date monograph. It may also be used by R & D professionals involved in the improvement of performance of drives in the industries. The book will also be beneficial to the researchers pursuing work on multiphase drives as well as sensorless and direct torque control of electric drives since up-to date references in these topics are provided. It will also provide few examples of modeling, analysis and control of electric drives using MATLAB/SIMULIN

  15. Simple Driving Techniques

    DEFF Research Database (Denmark)

    Rosendahl, Mads

    2002-01-01

    -like language. Our aim is to extract a simple notion of driving and show that even in this tamed form it has much of the power of more general notions of driving. Our driving technique may be used to simplify functional programs which use function composition and will often be able to remove intermediate data......Driving was introduced as a program transformation technique by Valentin Turchin in some papers around 1980. It was intended for the programming language REFAL and used in metasystem transitions based on super compilation. In this paper we present one version of driving for a more conventional lisp...

  16. Color temperature tunable white light LED system

    Science.gov (United States)

    Speier, Ingo; Salsbury, Marc

    2006-08-01

    Efficient white light LED systems with continuously tunable color temperature (CT) over a range of 3000 K to 6500 K are reviewed. Typically, white light sources have a fixed CT and color rendering index (CRI). White light with user-specified color temperatures is currently generated by solid-state systems with red green blue ("R/G/B"), red green blue amber ("R/G/B/A"), and warm white cool white ("WW/CW") LED combinations, but their performance is suboptimal for architectural lighting applications. We propose and discuss an LED module with a combination of warm white, green and blue ("WW/G/B") LEDs. In this scenario, the white LEDs have fixed intensity, while the blue and green LED intensities are adjusted to shift the LED module chromaticity along the blackbody locus. We also propose and discuss an LED module with a combination of red, green, blue, and cool white ("R/G/B/CW") LEDs. The white LEDs still have a fixed intensity, while the intensities of the red, green, and blue LEDs are again adjusted to shift the LED module chromaticity along the blackbody locus. The white LEDs ensure that an improved CRI is maintained in comparison to a simple "R/G/B" solution.

  17. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies

    Directory of Open Access Journals (Sweden)

    José Caetano Dell'Aglio Jr.

    2013-01-01

    Full Text Available This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-clinical OR community based. The search yielded a total of 434 papers, but only those published in peer-reviewed journals and with samples aged ≥ 18 years were included, resulting in a final sample of 18 papers. Results revealed rather heterogeneous findings concerning the prevalence of bipolar disorders and bipolar spectrum disorders. Lifetime prevalence of bipolar disorder ranged from 0.1 to 7.5%, whereas lifetime prevalence of bipolar spectrum disorders ranged from 2.4 to 15.1%. Differences in the rates of bipolar disorder and bipolar spectrum disorders may be related to the consideration of subthreshold criteria upon diagnosis. Differences in the prevalence of different subtypes of the disorder are discussed in light of diagnostic criteria and instruments applied.

  18. Fokusgruppeinterview som led i en evalueringsproces

    DEFF Research Database (Denmark)

    Andersen-Mølgaard, Hanna; Harrit, Ole

    2006-01-01

    Teoretiske begrundelser og perspektiver, responsiv-konstruktivistisk evaluering, fokusgruppeinterview som led i BIKVAmodellen, eksempler, vurdering og perspektivering......Teoretiske begrundelser og perspektiver, responsiv-konstruktivistisk evaluering, fokusgruppeinterview som led i BIKVAmodellen, eksempler, vurdering og perspektivering...

  19. Goniometric characterization of LED based greenhouse lighting

    DEFF Research Database (Denmark)

    Thorseth, Anders; Lindén, Johannes; Corell, Dennis Dan;

    2015-01-01

    This paper describes a demonstration of goniospectroradiometry for characterizations of new light emitting diode (LED) based luminaries for enhanced photosynthesis in greenhouses. It highlights the differences between measurement of the traditional high pressure sodium (HPS) luminaries and the LED...... based luminaries. The LED based luminaries are compared to traditional HPS luminaries; in terms of energy efficiency with regard to the photosynthetic photon flux, and the LED luminaries were found to be more effective than the HPS luminaries...

  20. Thermal Design for 5 Watt Power LED

    Institute of Scientific and Technical Information of China (English)

    WANG Cai-feng; NIU Ping-juan; GAO Tie-cheng; YANG Guang-hua; FU Xian-song

    2009-01-01

    With the consideration of the thermal management and heat sink requirements, a cooling device is designed and the thermal resistance of this device is calculated with a single 5 W power LED. The thermal design of a single 5 W power LED is reasonable, effective and the result has been simulated. This design also instruct other power LEDs' thermal design. Provided is a reliable and effective method for the design of power LED illumination lamps and lanterns.

  1. LED Traffic Light as Communication Device

    OpenAIRE

    Kwan, TO; Chan, CH; Liu, HS; Pang, GKH

    1999-01-01

    The visible light from an LED (light emitting diode) traffic light can be modulated and encoded with information. Hence, it can be used for the broadcasting of audio messages or any traffic or road information. Essentially all LED traffic lights can be used as communications devices. The paper focuses on the description of an audio information system made up of high brightness, visible light emitting diodes (LEDs) in which one or more LEDs are modulated and encoded with audio messages. The sy...

  2. ‘No Blue’ White LED

    OpenAIRE

    Ou, Haiyan; Corell, Dennis Dan; Dam-Hansen, Carsten; Petersen, Paul Michael; Friis, Dan

    2010-01-01

    This paper explored the feasibility of making a white LED light source by color mixing method without using the blue color. This ‘no blue’ white LED has potential applications in photolithography room illumination, medical treatment and biophotonics research. A no-blue LED was designed, and the prototype was fabricated. The spectral power distribution of both the LED bulb and the yellow fluorescent tube was measured. Based on that, colorimetric values were calculated and compared on terms of ...

  3. Dual use of LED traffic signal system

    OpenAIRE

    Cheung, SW; Yang, ES; Tam, YY; Man, CW; D. Yang

    1999-01-01

    The dual use, signaling and communication, of LED traffic signal system is described and analyzed. The primary function of a traffic light system is to give traffic and pedestrian signals. A prototype of LED traffic signal head is developed to perform a secondary function: communication. A wireless communication link is set up using the LED traffic signal head as the transmitter. The LEDs are modulated to transmit information-carrying light. The receiver uses a silicon photodiode to detect th...

  4. Long-term Treatment in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Meliha Zengin Eroglu

    2010-08-01

    Full Text Available Although the importance of long-term prophylactic treatment is certain in bipolar disorder, there is stil debate on how to which patients and evaluate the treatment response. Efficacious long-term treatment can reduce morbidity and mortality significantly and improve quality of life of bipolar patients. The concept of ideal response should also be defined very clearly in order to discuss the difficulties of measuring the effectiveness of the prophylactic treatment. The aims of this paper are to determine whether our currently methods and criteria are valid, reliable and sensitive evaluating the efficacy of the treatment response and to briefly inform the clinicians about the drugs used in pharmacologic prophylaxis in accordance with relevant data.

  5. Bipolar zinc/oxygen battery development

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, S. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Schlatter, C. [Swiss Federal Inst. of Technology, Lausanne (Switzerland)

    1997-06-01

    A bipolar electrically rechargeable Zn/O{sub 2} battery has been developed. Reticulated copper foam served as substrate for the zinc deposit on the anodic side, and La{sub 0.6}Ca{sub 0.4}CoO{sub 3}-catalyzed bifunctional oxygen electrodes were used on the cathodic side of the cells. The 100 cm{sup 2} unit cell had an open circuit voltage of 1,4 V(O{sub 2}) in moderately alkaline electrolyte. The open circuit voltage and the peak power measured for a stack containing seven cells were ca. 10V and 90W, respectively. The current-potential behaviour was determined as a function of the number of bipolar cells, and the maximum discharge capacity was determined at different discharge rates. (author) 4 figs., 1 ref.

  6. Current Propagation in Narrow Bipolar Pulses

    Science.gov (United States)

    Watson, S. S.; Marshall, T. C.

    2005-12-01

    We model the observed electric fields of a particular narrow bipolar pulse (NBP) published in Eack [2004]. We assume an exponential growth of current carriers due to a runaway breakdown avalanche and show that this leads to a corresponding increase in current. With specific input values for discharge altitude, length, current, and propagation velocity, the model does a good job of reproducing the observed near and far electric field. The ability of the model to reproduce the observed electric fields is an indication that our assumptions concerning the runaway avalanche may be correct, and this indication is further strengthened by the inability of the simple transmission line model to reproduce simultaneously both the near and far electric fields. Eack, K. B. (2004), Electrical characteristics of narrow bipolar events, Geophys. Res. Lett., 31, L20102, doi:10.1029/2004/GL021117.

  7. Comorbidity of Asperger's syndrome and Bipolar disorder

    Directory of Open Access Journals (Sweden)

    Azzoni Antonella

    2008-11-01

    Full Text Available Abstract Background and objective Asperger's Syndrome (AS is a pervasive developmental disorder that is sometimes unrecognized, especially in the adult psychiatric setting. On the other hand, in patients with an AS diagnosis, comorbid psychiatric disorders may be unrecognized in the juvenile setting. The aim of the paper is to show and discuss some troublesome and complex problems of the management of patients with AS and comorbid Bipolar Disorder (BD. Methods The paper describes three patients affected by AS and bipolar spectrum disorders. Results and conclusion Mood stabilizers and 2nd generation antipsychotics were effective in the treatment of these AS patients with comorbid BD, while the use of antidepressants was associated with worsening of the mood disorder. It is of importance to recognize both the psychiatric diagnoses in order to arrange an exhaustive therapeutic program and to define specific and realistic goals of treatment.

  8. Subjective experiences in schizophrenia and bipolar disorders.

    Science.gov (United States)

    Arduini, Luca; Kalyvoka, Artemis; Stratta, Paolo; Gianfelice, Daniela; Rinaldi, Osvaldo; Rossi, Alessandro

    2002-02-01

    Studies comparing 'subjective experiences' in schizophrenic and affective disorders have reached inconclusive results. We investigated the pattern of 'subjective perceived cognitive disturbances' in a group of 55 schizophrenic patients and 39 bipolar patients hospitalized for an index psychotic episode. The assessment of the subjective experiences was made using the Frankfurter Beschwerde-Fragebogen (FBF). Comparing the two groups on the four FBF factors, schizophrenic patients showed significantly higher scores in the areas of 'central cognitive disturbances', 'perception and motility' other than a significantly higher FBF total score. Our results suggest that cognitive, perception and motility disturbances are the most characteristic subjective experiences of schizophrenic patients in comparison with bipolar patients. This finding need to be further explored in light of the issue of cognitive dysfunction in schizophrenia. PMID:12056578

  9. Bias in emerging biomarkers for bipolar disorder

    DEFF Research Database (Denmark)

    Carvalho, A F; Köhler, C A; Fernandes, B S;

    2016-01-01

    BACKGROUND: To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. METHOD: The Pubmed/Medline, E......BACKGROUND: To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. METHOD: The Pubmed......) was observed in 11 meta-analyses. Heterogeneity was high for (I 2 ⩾ 50%) 16 meta-analyses. Only two biomarkers met criteria for suggestive evidence namely the soluble IL-2 receptor and morning cortisol. The median power of included studies, using the effect size of the largest dataset as the plausible...

  10. Optical orientation in bipolar spintronic devices

    International Nuclear Information System (INIS)

    Optical orientation is a highly efficient tool for the generation of nonequilibrium spin polarization in semiconductors. Combined with spin-polarized transport it offers new functionalities for conventional electronic devices, such as pn junction bipolar diodes or transistors. In nominally nonmagnetic junctions optical orientation can provide a source for spin capacitance—the bias-dependent nonequilibrium spin accumulation—or for spin-polarized current in bipolar spin-polarized solar cells. In magnetic junctions, the nonequilibrium spin polarization generated by spin orientation in the proximity of an equilibrium magnetization gives rise to the spin-voltaic effect (a realization of the Silsbee–Johnson coupling), enabling efficient control of electrical properties such as the I–V characteristics of the junctions by magnetic and optical fields. This paper reviews the main results of investigations of spin-polarized and magnetic pn junctions, from spin capacitance to the spin-voltaic effect

  11. Studies of offspring of parents with bipolar disorder.

    Science.gov (United States)

    Chang, Kiki; Steiner, Hans; Ketter, Terence

    2003-11-15

    Children and adolescents who are the biological offspring of individuals with bipolar disorder (BD) (bipolar offspring) represent a population rich in potential for revealing important aspects in the development of BD. Multiple cross-sectional assessments of psychopathology in bipolar offspring have confirmed high incidences of BD, as well as mood and behavioral disorders, and other psychopathology in this population. Longitudinal studies of offspring have begun to shed light on precursors of BD development. Other assessments of bipolar offspring have included dimensional reports of psychiatric and psychosocial functioning, temperament assessments, and descriptions of family environments and parenting styles. Neurobiological studies in bipolar offspring are just beginning to yield findings that may be related to the underlying neuropathophysiology of BD. The future holds promise for longitudinal studies of bipolar offspring incorporating all of these facets, including genetic analyses, to further elucidate the factors involved in the evolution of BD. PMID:14601034

  12. Unmet needs of bipolar disorder patients

    OpenAIRE

    Hajda M; Prasko J; Latalova K; Hruby R; Ociskova M; Holubova M; Kamaradova D; Mainerova B

    2016-01-01

    Miroslav Hajda,1 Jan Prasko,1 Klara Latalova,1 Radovan Hruby,2 Marie Ociskova,1 Michaela Holubova,1,3 Dana Kamaradova,1 Barbora Mainerova1 1Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, Czech Republic; 2Outpatient Psychiatric Department, Martin, Slovak Republic; 3Department of Psychiatry, Regional Hospital Liberec, Liberec, Czech Republic Background: Bipolar disorder (BD) is a serious mental illness with advers...

  13. Bipolar Outflows and the Evolution of Stars

    OpenAIRE

    Frank, Adam

    1998-01-01

    Hypersonic bipolar outflows are a ubiquitous phenomena associated with both young and highly evolved stars. Observations of Planetary Nebulae, the nebulae surrounding Luminous Blue Variables such as $\\eta$ Carinae, Wolf Rayet bubbles, the circumstellar environment of SN 1987A and Young Stellar Objects all revealed high velocity outflows with a wide range of shapes. In this paper I review the current state of our theoretical understanding of these outflows. Beginning with Planetary Nebulae con...

  14. Paired structures and bipolar knowledge representation

    OpenAIRE

    Montero, Javier; Bustince, H.; Franco, C.; Rodríguez, Juan Tinguaro; Gómez, Daniel; Pagola, Miguel; Fernandez, Javier; Barrenechea, Edurne

    2014-01-01

    In this strictly positional paper we propose a general approach to bipolar knowledge representation, where the meaning of concepts can be modelled by examining their decomposition into opposite and neutral categories. In particular, it is the semantic relationship between the opposite categories which suggests the emergence of a paired structure and its associated type of neutrality, being there three general types of neutral categories, namely indeterminacy, ambivalence and conflict. Hence, ...

  15. Olanzapine Discontinuation Emergent Recurrence in Bipolar Disorder

    OpenAIRE

    Manu Arora; Samir Kumar Praharaj

    2014-01-01

    Objective: The efficacy of atypical antipsychotics including olanzapine in acute treatment of manic episode has been established, whereas its role in maintenance treatment is not clear. Materials and Methods: Thirteen patients of bipolar disorder who were on regular treatment with mood stabilizer and subsequently relapsed into mania or depressive episode after discontinuation of olanzapine were studied for various socio-demographic and clinical factors using retrospective chart review. Result...

  16. The Bipolar Quantum Drift-diffusion Model

    Institute of Scientific and Technical Information of China (English)

    Xiu Qing CHEN; Li CHEN

    2009-01-01

    A fourth order parabolic system, the bipolar quantum drift-diffusion model in semiconductor simulation, with physically motivated Dirichlet-Neumann boundary condition is studied in this paper. By semidiscretization in time and compactness argument, the global existence and semiclassical limit are obtained, in which semiclassical limit describes the relation between quantum and classical drift-diffusion models. Furthermore, in the case of constant doping, we prove the weak solution exponentially approaches its constant steady state as time increases to infinity.

  17. Bipolarity and Ambivalence in Landscape Architecture

    OpenAIRE

    Koh, J.

    2010-01-01

    Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific. Furthermore, within landscape architecture there is a gap between design (as implied by architecture) and planning (implying land-use plan and policy orientation) on one hand, and a similar gap between design (associated with artistic activity, concerned with aesthetics as well as science) and research (considere...

  18. Bipolar electrochemistry for high throughput screening applications

    OpenAIRE

    Munktell, Sara

    2016-01-01

    Bipolar electrochemistry is an interesting concept for high throughput screening techniques due to the ability to induce gradients in a range of materials and their properties, such as composition, particle size, or dopant levels, among many others. One of the key advantages of the method is the ability to test, create or modify materials without the need for a direct electrical connection. In this thesis, the viability of this method has been explored for a range of possible applications, su...

  19. Thought Suppression in Patients With Bipolar Disorder

    OpenAIRE

    Miklowitz, David J.; Alatiq, Yousra; Geddes, John R.; Goodwin, Guy M.; Williams, J. Mark G.

    2010-01-01

    Suppression of negative thoughts has been observed under experimental conditions among patients with major depressive disorder (MDD) but has never been examined among patients with bipolar disorder (BD). Patients with BD (n = 36), patients with MDD (n = 20), and healthy controls (n = 20) completed a task that required unscrambling 6-word strings into 5-word sentences, leaving out 1 word. The extra word allowed the sentences to be completed in a negative, neutral, or “hyperpositive” (manic/goa...

  20. Partial Rodent Genetic Models for Bipolar Disorder

    OpenAIRE

    Chen, Guang; Henter, Ioline D.; Manji, Husseini K

    2011-01-01

    Bipolar disorder (BPD) is a complex clinical phenomenon. This episodic illness comprises at least four features/components: depression, mania, vulnerability to mood swings in euthymic BPD patients, and spontaneous cyclicity in at least some BPD patients. Currently, there is no rodent genetic model capable of encompassing the whole phenotype of BPD exists; however, recent genetic-behavioral studies have delineated partial models for some components of BPD, namely, depression, mania, and vulner...

  1. Comorbidity of Asperger's syndrome and Bipolar disorder

    OpenAIRE

    Azzoni Antonella; Raja Michele

    2008-01-01

    Abstract Background and objective Asperger's Syndrome (AS) is a pervasive developmental disorder that is sometimes unrecognized, especially in the adult psychiatric setting. On the other hand, in patients with an AS diagnosis, comorbid psychiatric disorders may be unrecognized in the juvenile setting. The aim of the paper is to show and discuss some troublesome and complex problems of the management of patients with AS and comorbid Bipolar Disorder (BD). Methods The paper describes three pati...

  2. Bipolar high voltage pulse power generator

    Czech Academy of Sciences Publication Activity Database

    Lukeš, Petr; Člupek, Martin; Babický, Václav; Šunka, Pavel

    Monterey : IEEE, 2007 - (Maenchen, J.; Schamiloglu, E.), s. 1061-1064 ISBN 0-7803-9190-X. [IEEE International Pulsed Power Conference/15th./. Portola Plaza Hotel, Monterey (US), 13.06.2005-17.06.2005] R&D Projects: GA AV ČR KSK2043105 Institutional research plan: CEZ:AV0Z20430508 Keywords : bipolar * pulse power generator * corona discharge Subject RIV: BL - Plasma and Gas Discharge Physics

  3. Circadian secretion of cortisol in bipolar disorder

    Science.gov (United States)

    Cervantes, Pablo; Gelber, Stephen; Kin, François; Nair, Vasavan N.P.; Schwartz, George

    2001-01-01

    Objective To compare the 24-h cortisol secretion profiles of normal control subjects and patients with bipolar disorder who were in the depressive, manic and euthymic phases of the disorder. Participants Eighteen patients, 25–62 years of age, in depressed (n = 5), manic (n = 5) or euthymic (n = 8) phase of bipolar disorder recruited through a psychiatric outpatient clinic, and 5 control subjects, 24–41 years of age, recruited through advertisement or word of mouth. Outcome measures Subjects were interviewed and symptom ratings were obtained using the Hamilton Depression Rating Scale, Beck Depression Inventory and Young Mania Scale. Blood collection began at 0800 and continued at hourly intervals for 24 h. Serum cortisol levels were assayed using a validated commercial radioimmunoassay kit. Results An analysis of variance of the area under the cortisol 24-h time-concentration curve (AUC) revealed a significant difference between the control group and patient groups (F = 3.69, p = 0.03). The mean AUCs of the patients in the depressed (263.4 μg/dL) and hypomanic (262.2 μg/dL) phases were beyond the 95% confidence interval for the controls (120.9–253.3 μg/dL). There were no significant group differences in cosinor acrophase and no significant effects of sex, education, age of illness onset, duration of illness or duration of mood state at time of testing on the cortisol measures. Pearson correlations between symptom rating scores and cortisol secretion variables were not significant. Conclusion The increases in cortisol secretion in patients in both the depressed and manic phases of bipolar disorder suggest that cortisol level is probably not a state marker in bipolar disorder. PMID:11762208

  4. An atmospheric origin of the multi-decadal bipolar seesaw

    Science.gov (United States)

    Wang, Zhaomin; Zhang, Xiangdong; Guan, Zhaoyong; Sun, Bo; Yang, Xin; Liu, Chengyan

    2015-03-01

    A prominent feature of recent climatic change is the strong Arctic surface warming that is contemporaneous with broad cooling over much of Antarctica and the Southern Ocean. Longer global surface temperature observations suggest that this contrasting pole-to-pole change could be a manifestation of a multi-decadal interhemispheric or bipolar seesaw pattern, which is well correlated with the North Atlantic sea surface temperature variability, and thus generally hypothesized to originate from Atlantic meridional overturning circulation oscillations. Here, we show that there is an atmospheric origin for this seesaw pattern. The results indicate that the Southern Ocean surface cooling (warming) associated with the seesaw pattern is attributable to the strengthening (weakening) of the Southern Hemisphere westerlies, which can be traced to Northern Hemisphere and tropical tropospheric warming (cooling). Antarctic ozone depletion has been suggested to be an important driving force behind the recently observed increase in the Southern Hemisphere's summer westerly winds; our results imply that Northern Hemisphere and tropical warming may have played a triggering role at an stage earlier than the first detectable Antarctic ozone depletion, and enhanced Antarctic ozone depletion through decreasing the lower stratospheric temperature.

  5. Suicide attempts and clinical features of bipolar patients

    OpenAIRE

    Berkol, Tonguç D.; İslam, Serkan; Kırlı, Ebru; Pınarbaşı, Rasim; Özyıldırım, İlker

    2016-01-01

    Objectives: To identify clinical predictors of suicide attempts in patients with bipolar disorder. Methods: This study included bipolar patients who were treated in the Psychiatry Department, Haseki Training and Research Hospital, Istanbul, Turkey, between 2013 and 2014; an informed consent was obtained from the participants. Two hundred and eighteen bipolar patients were assessed by using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition...

  6. Quetiapine: A Pharmacoeconomic Review of its Use in Bipolar Disorder

    OpenAIRE

    Greg L. Plosker

    2012-01-01

    This article briefly summarizes the burden of bipolar disorder and the clinical profile of quetiapine (Seroquel) in the management of bipolar disorder, followed by a detailed review of pharmacoeconomic analyses. Quetiapine is an atypical antipsychotic that is available in numerous countries as immediate-release and extended-release tablets for the treatment of major psychiatric disorders, including bipolar disorder. Randomized, double-blind, placebo-controlled trials with quetiapine have demo...

  7. Binary hypotheses for bipolar mass loss in transients

    OpenAIRE

    Fitzpatrick, Benedict John Russell; Podsiadlowski, Philipp

    2012-01-01

    We investigate binary hypotheses for the formation of bipolar nebulae using the smoothed particle hydrodynamics code Gadget-2. In the general case, we present a parameter study of mass loss from very simple common envelope models, which seems to show a strongly bipolar trend for sufficiently oblate envelopes and low enough spiral-in injection energy. The density profiles of the envelopes produce differing structure within the ejecta. We also investigate 3 specific bipolar ma...

  8. The psychoeducational impact on cognitive inhibition among euthymic bipolar patients

    OpenAIRE

    Novak, Tatjana

    2010-01-01

    Across all mood phases of bipolar disorder emotional dysregulation, attentional and cognitive control deficits are being consistently observed. Despite the efficacy of psychoeducational (PE) approaches in stabilising and preventing mood episodes in bipolar disorder, no published studies directly examined the impact of psychosocial interventions on cognition of bipolar patients. Our aim was twofold: to assess the impact of PE intervention on cognitive inhibition measures and to examine emotion...

  9. Family Environment and Suicidal Ideation Among Bipolar Youth

    OpenAIRE

    Goldstein, Tina R; Birmaher, Boris; Axelson, David; Goldstein, Benjamin I.; Gill, Mary Kay; Esposito-Smythers, Christianne; Ryan, Neal D.; Strober, Michael A.; Hunt, Jeffrey; Keller, Martin

    2009-01-01

    The objective of this study was to examine the association between family environment and suicidal ideation among youth with bipolar disorder. Subjects included 446 bipolar (BP) youth (age 7–17) enrolled in the Course and Outcome of Bipolar Youth study. Current suicidal ideation, family functioning and family stress were assessed at intake. BP youth with current suicidal ideation reported more conflict with their mother and less family adaptability. Ideators endorsed more stressful family eve...

  10. Commercialization of Fuel Cell Bipolar Plate Manufacturing by Electromagnetic Forming

    OpenAIRE

    Daehn, G. S.; Hatkevich, S.; Shang, J.; Wilkerson, L.

    2010-01-01

    The cost of manufacturing bipolar plates is a major component to the overall cost structure of a Proton Exchange Membrane (PEM) fuel cell stack. To achieve the commercialization of PEM fuel cells, a high volume and low cost manufacturing process for the bipolar plate must be developed. American Trim has identified high velocity electromagnetic forming as a suitable technology to manufacture metallic fuel cell bipolar plates, because of its low capital cost, flexible tooling and rapid prototyp...

  11. Bipolar Disorder: What Can Psychotherapists Learn From the Cognitive Research?

    OpenAIRE

    Johnson, Sheri; Tran, Tanya

    2007-01-01

    Randomized controlled trials of psychological treatment, principally cognitive therapy, for bipolar disorder have yielded inconsistent results. Given the status of this evidentiary base, we provide a more fine-grained analysis of the cognitive profiles associated with bipolar disorder to inform clinical practice. In this practice-friendly review, we consider evidence that both negative and positive cognitive styles are related to bipolar disorder. Cross-sectional and prospective evidence sugg...

  12. Valproate in Bipolar Disorder: Case Examples From a Family Practice

    OpenAIRE

    Manning, J. Sloan

    1999-01-01

    Valproate, an antiepileptic drug, is useful in the management of various nonepileptic disorders. It is an effective and generally well-tolerated medication for the treatment of bipolar disorder and has been approved by the Food and Drug Administration for use in manic states. Studies also suggest that it is effective in other bipolar spectrum illnesses. This report describes 2 clinical cases of DSM-IV bipolar disorder where valproate provided robust, sustained relief of mood symptoms. In the ...

  13. Altered Neurochemical Ingredient of Hippocampus in Patients with Bipolar Depression

    OpenAIRE

    Murad Atmaca; Hanefi Yildirim

    2012-01-01

    Background. In a number of investigations, hippocampal neurochemicals were evaluated in the patients with bipolar disorder who were on their first episode or euthymic periods. However, we did not meet any investigation in which only patients with bipolar depression were examined. As a consequence, the objective of the present study was to examine both sides of hippocampus of patients with bipolar disorder in depressive episode and healthy controls using 1H-MRS. Methods. Thirteen patients with...

  14. Treating bipolar disorder. Evidence-based guidelines for family medicine.

    OpenAIRE

    McIntyre, Roger S; Mancini, Deborah A.; Lin, Peter; Jordan, John

    2004-01-01

    OBJECTIVE: To provide an evidence-based summary of medications commonly used for bipolar disorders and a practical approach to managing bipolar disorders in the office. QUALITY OF EVIDENCE: Articles from 1990 to 2003 were selected from MEDLINE using the key words "bipolar disorder," "antiepileptics," "antipsychotics," "antidepressants," and "mood stabilizers." Good-quality evidence for many of these treatments comes from randomized trials. Lithium, divalproex, carbamazepine, lamotrigine, oxca...

  15. Bipolar disorder and metabolic syndrome: a systematic review

    OpenAIRE

    Letícia Czepielewski; Ledo Daruy Filho; Elisa Brietzke; Rodrigo Grassi-Oliveira

    2013-01-01

    OBJECTIVE: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). METHODS: A systematic review of the literature was conducted using the Medline, Embase and PsycInfo databases, using the keywords "metabolic syndrome", "insulin resistance" and "metabolic X syndrome" and cross-referencing them with "bipolar disorder" or "mania". The following types of publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed with bipolar disorder or (ii...

  16. The Neurobiology of Bipolar Disorder: An Integrated Approach

    OpenAIRE

    Muneer, Ather

    2016-01-01

    Bipolar disorder is a heterogeneous condition with myriad clinical manifestations and many comorbidities leading to severe disabilities in the biopsychosocial realm. The objective of this review article was to underline recent advances in knowledge regarding the neurobiology of bipolar disorder. A further aim was to draw attention to new therapeutic targets in the treatment of bipolar disorder. To accomplish these goals, an electronic search was undertaken of the PubMed database in August 201...

  17. Broadening the diagnosis of bipolar disorder: benefits vs. risks

    OpenAIRE

    Strakowski, Stephen M.; Fleck, David E.; MAJ, MARIO

    2011-01-01

    There is considerable debate over whether bipolar and related disorders that share common signs and symptoms, but are currently defined as distinct clinical entities in DSM-IV and ICD-10, may be better characterized as falling within a more broadly defined “bipolar spectrum”. With a spectrum view in mind, the possibility of broadening the diagnosis of bipolar disorder has been proposed. This paper discusses some of the rationale for an expanded diagnostic scheme from both cl...

  18. The Bipolar Interactive Psychoeducation (BIPED) study: trial design and protocol

    OpenAIRE

    Jones Ian; Craddock Nick; Cohen David; Hood Kerry; Griffiths Emily; Barnes Emma; Simpson Sharon; Smith Daniel J

    2009-01-01

    Abstract Background Bipolar disorders affect between 3–5% of the population and are associated with considerable lifelong impairment. Since much of the morbidity associated with bipolar disorder is caused by recurrent depressive symptoms, which are often only poorly responsive to antidepressants, there is a need to develop alternative, non-pharmacological interventions. Psychoeducational interventions have emerged as promising long-term therapeutic options for bipolar disorder. Methods/design...

  19. Bipolar Bozukluk Obsesif Kompulsif Bozukluk Birlikteliği

    OpenAIRE

    Necla Keskin; Lut Tamam

    2014-01-01

    The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients. Some genetic variants, neurotransmitters especially serotonergic systems and second-messenger systems are thought to be responsible for its etiology. Bipolar disorder alters the clinical aspects of obsessive compulsive disorder and is associated with poorer outcome. The determination of comorbidity between bip...

  20. Undiagnosed Bipolar Disorder: New Syndromes and New Treatments

    OpenAIRE

    Glick, Ira D.

    2004-01-01

    Recent studies have indicated that bipolar disorder is more common than previously believed. The socioeconomic and personal burdens of this illness are significant, and the lifetime risk of suicide attempts by patients with bipolar II disorder is high. It is not uncommon for patients with bipolar disorder, especially those presenting with depression, to be seen first in a primary care setting; therefore, primary care physicians need to be ready to diagnose and manage patients with these menta...

  1. Cognitive impairment in manic bipolar patients: important, understated, significant aspects

    OpenAIRE

    Vrabie, Mădălina; Marinescu, Victor; Talaşman, Anca; Tăutu, Oana; Drima, Eduard; Micluţia, Ioana

    2015-01-01

    Background Bipolar disorder is a chronic mood disorder with episodic progress and high relapse rate. Growing evidence suggests that individuals with bipolar disorder display cognitive impairment which persists even throughout periods of symptom's remission. Method 137 bipolar patients met the inclusion criteria (depressive episode: DSM-IV-TR criteria for major depressive episode, HAMD score ≥17; manic/hypomanic episode: DSM-IV-TR criteria for manic/hypomanic episode, YMRS score ≥12, euthymic:...

  2. Symptom severity of bipolar disorder during the menopausal transition

    OpenAIRE

    Marsh, Wendy K.; Gershenson, Bernice; Rothschild, Anthony J.

    2015-01-01

    Background Little is known about the mood symptom experience of women with bipolar disorder during the menopausal transition (MT). Yet times of rapid hormonal decline, such as the postpartum, are associated with increased risk of severe mood episodes in bipolar disorder, and the MT is a time of increased risk for unipolar depression in women with or without a history of depression. Methods Enrollment included 56 women 40–60 years old diagnosed in the bipolar spectrum who were experiencing men...

  3. Current and Emerging Therapies for the Management of Bipolar Disorders

    OpenAIRE

    El-Mallakh, Rif S; Elmaadawi, Ahmed Z.; Yonglin Gao; Kavita Lohano; R. Jeannie Roberts

    2011-01-01

    Bipolar disorder is a complex condition to treat because agents that may be effective for a specific phase may not be effective for other phases, or may even worsen the overall course of the illness. Over the last decade there has been an increase in research activity in the treatment of bipolar illness. There are now several agents that are well established for the treatment of acute mania (lithium, divalproex, carbamazepine, nearly all antipsychotics), acute bipolar depression (lamotrigine,...

  4. The relationship between borderline personality disorder and bipolar disorder

    OpenAIRE

    Zimmerman, Mark; Morgan, Theresa A

    2013-01-01

    It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We reviewed the most studied question on the relationship between BPD and bipolar disorder: their diagnostic concordance. Across studies, approximately 10% of patients with BPD had bi...

  5. Bipolarna motnja razpoloženja: Bipolar disorder:

    OpenAIRE

    Dernovšek, Mojca Zvezdana; Frangeš, Tadeja

    2013-01-01

    Bipolar disorder is very prevalent in general population. According to Diagnostic and statistical manual ofmental disorders, fourth revision - DSM-IV, four types ofbipolar disorder are distinguished: bipolar disorder 1, bipolar disorder II, cyclothymia, and other types (not specified otherwise). Etiology of disorder is multifactorial with overlap between genetic, environmental"and neurobiological factors. Due to complexity of clinical features it represents diagnostical and therapeutical chal...

  6. Sex Dependence of Cognitive Functions in Bipolar Disorder

    OpenAIRE

    Aleksandra Suwalska; Dorota Łojko

    2014-01-01

    The objective of the present study was to assess the performance of lithium treated euthymic bipolar patients in tests measuring spatial working memory (SWM), planning, and verbal fluency and to delineate the influence of gender on cognitive functioning. Fifty-nine euthymic bipolar patients, treated with lithium carbonate for at least 5 yr, were studied. Patients and controls underwent a neuropsychological assessment. Bipolar patients had significantly worse results than the healthy controls ...

  7. Olanzapine discontinuation emergent recurrence in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Manu Arora

    2014-01-01

    Full Text Available Objective: The efficacy of atypical antipsychotics including olanzapine in acute treatment of manic episode has been established, whereas its role in maintenance treatment is not clear. Materials and Methods: Thirteen patients of bipolar disorder who were on regular treatment with mood stabilizer and subsequently relapsed into mania or depressive episode after discontinuation of olanzapine were studied for various socio-demographic and clinical factors using retrospective chart review. Results: There was no correlation found between the period of tapering olanzapine, time to recurrence of episode after discontinuation, and the dosage of olanzapine at the time of discontinuation. The predominant early signs of relapse after discontinuation of olanzapine included sleep disturbance (72.7%, lack of insight for change in behavior (72.7%, irritability (54.5%, and elevated mood (45.5%. Conclusion: Mood stabilizer alone as a maintenance therapy of bipolar disorder may be inadequate for long-term management. A low dose of olanzapine along with mood stabilizers might be useful for prevention of recurrence in bipolar disorder.

  8. Bipolar cautery forceps: An economical version

    Directory of Open Access Journals (Sweden)

    Appukuttan Aswin

    2007-01-01

    Full Text Available Context: Bipolar cautery forceps are an expensive instrument and especially in Government Medical colleges and Government Hospitals, getting a pair is a very tedious and prolonged task due to official reasons. Aims: To make a cheap and easily obtainable bipolar cautery forceps. Settings and Design: The reason for innovation was that the cautery forceps in the department were out of order and we were not getting replacements. Materials and Methods: Made from condemned and damaged forceps or from stainless steel nonsurgical forceps which are very low-cost, very cheap and easy to get hold of, especially in a Government institution with limited resources. Results: It has been used for the past one and a half years in our Department for plastic surgical procedures, including microvascular surgery. Initially, it was designed when the cautery forceps in the department were out of order and we were not getting replacements and later on, it became part of the routine set as it was found to be equally good. Conclusions: A very cheap and useful alternative to the commercially available bipolar cautery forceps has been made.

  9. Historical Underpinnings of Bipolar Disorder Diagnostic Criteria

    Directory of Open Access Journals (Sweden)

    Brittany L. Mason

    2016-07-01

    Full Text Available Mood is the changing expression of emotion and can be described as a spectrum. The outermost ends of this spectrum highlight two states, the lowest low, melancholia, and the highest high, mania. These mood extremes have been documented repeatedly in human history, being first systematically described by Hippocrates. Nineteenth century contemporaries Falret and Baillarger described two forms of an extreme mood disorder, with the validity and accuracy of both debated. Regardless, the concept of a cycling mood disease was accepted before the end of the 19th century. Kraepelin then described “manic depressive insanity” and presented his description of a full spectrum of mood dysfunction which could be exhibited through single episodes of mania or depression or a complement of many episodes of each. It was this concept which was incorporated into the first DSM and carried out until DSM-III, in which the description of episodic mood dysfunction was used to build a diagnosis of bipolar disorder. Criticism of this approach is explored through discussion of the bipolar spectrum concept and some recent examinations of the clinical validity of these DSM diagnoses are presented. The concept of bipolar disorder in children is also explored.

  10. Historical Underpinnings of Bipolar Disorder Diagnostic Criteria.

    Science.gov (United States)

    Mason, Brittany L; Brown, E Sherwood; Croarkin, Paul E

    2016-01-01

    Mood is the changing expression of emotion and can be described as a spectrum. The outermost ends of this spectrum highlight two states, the lowest low, melancholia, and the highest high, mania. These mood extremes have been documented repeatedly in human history, being first systematically described by Hippocrates. Nineteenth century contemporaries Falret and Baillarger described two forms of an extreme mood disorder, with the validity and accuracy of both debated. Regardless, the concept of a cycling mood disease was accepted before the end of the 19th century. Kraepelin then described "manic depressive insanity" and presented his description of a full spectrum of mood dysfunction which could be exhibited through single episodes of mania or depression or a complement of many episodes of each. It was this concept which was incorporated into the first DSM and carried out until DSM-III, in which the description of episodic mood dysfunction was used to build a diagnosis of bipolar disorder. Criticism of this approach is explored through discussion of the bipolar spectrum concept and some recent examinations of the clinical validity of these DSM diagnoses are presented. The concept of bipolar disorder in children is also explored. PMID:27429010

  11. Recurrence and Relapse in Bipolar Mood Disorder

    Directory of Open Access Journals (Sweden)

    S Gh Mousavi

    2004-06-01

    Full Text Available Background: Despite the effectiveness of pharmacotherapy in acute phase of bipolar mood disorder, patients often experience relapses or recurrent episodes. Hospitalization of patients need a great deal of financial and humanistic resources which can be saved through understanding more about the rate of relapse and factors affecting this rate. Methods: In a descriptive analytical study, 380 patients with bipolar disorder who were hospitalized in psychiatric emergency ward of Noor hospital, Isfahan, Iran, were followed. Each patient was considered for; the frequency of relapse and recurrence, kind of pharmachotherapy, presence of psychotherapeutic treatments, frequency of visits by psychiatrist and the rank of present episode. Results: The overall prevalence of recurrence was 42.2%. Recurrence was lower in patients using lithium carbonate or sodium valproate or combined therapy (about 40%, compared to those using carbamazepine (80%. Recurrence was higher in patients treated with only pharmacotherapy (44.5% compared to those treated with both pharmacotherapy and psychotherapy (22.2%. Patients who were visited monthy by psychiatrist had lower rate of recurrence compared to those who had irregular visits. Conclusion: The higher rate of recurrence observed in carbamazepine therapy may be due to its adverse reactions and consequently poor compliance to this drug. Lower rates of recurrence with psychotherapy and regular visits may be related to the preventive effects of these procedures and especially to the effective management of stress. Keywords: Bipolar Mood Disorder, Recurrence, Relapse.

  12. A Color LED Driver Implemented by the Active Clamp Forward Converter

    Directory of Open Access Journals (Sweden)

    C. H. Chang

    2013-03-01

    Full Text Available Because light emitting diodes (LEDs have the advantages of dc working voltage, high luminescent efficiency, shortignition time, high reliability and pollution free, they have substituted for incandescent bulbs and fluorescent lampsgradually. In order to simplify circuit complexity, an active clamp forward converter with the sequential color display(SCD control is proposed to drive red, green and blue (RGB LED arrays. The proposed converter has zero-voltageswitching (ZVS operations of both the main switch and the auxiliary switch, resulting in high system efficiency. DrivingRGB LED arrays sequentially by one converter can save components and reduce cost significantly. Additionally, thepulse-width modulation (PWM control is applied to achieve a large chromaticity variation. The circuit operations areanalyzed in detail and the circuit parameters are designed based on the practical considerations. Finally, an illustrativeexample is implemented to demonstrate the feasibility and validity of the proposed LED driver.

  13. Design of the control system for full-color LED display based on MSP430 MCU

    Science.gov (United States)

    Li, Xue; Xu, Hui-juan; Qin, Ling-ling; Zheng, Long-jiang

    2013-08-01

    The LED display incorporate the micro electronic technique, computer technology and information processing as a whole, it becomes the most preponderant of a new generation of display media with the advantages of bright in color, high dynamic range, high brightness and long operating life, etc. The LED display has been widely used in the bank, securities trading, highway signs, airport and advertising, etc. According to the display color, the LED display screen is divided into monochrome screen, double color display and full color display. With the diversification of the LED display's color and the ceaseless rise of the display demands, the LED display's drive circuit and control technology also get the corresponding progress and development. The earliest monochrome screen just displaying Chinese characters, simple character or digital, so the requirements of the controller are relatively low. With the widely used of the double color LED display, the performance of its controller will also increase. In recent years, the full color LED display with three primary colors of red, green, blue and grayscale display effect has been highly attention with its rich and colorful display effect. Every true color pixel includes three son pixels of red, green, blue, using the space colour mixture to realize the multicolor. The dynamic scanning control system of LED full-color display is designed based on MSP430 microcontroller technology of the low power consumption. The gray control technology of this system used the new method of pulse width modulation (PWM) and 19 games show principle are combining. This method in meet 256 level grayscale display conditions, improves the efficiency of the LED light device, and enhances the administrative levels feels of the image. Drive circuit used 1/8 scanning constant current drive mode, and make full use of the single chip microcomputer I/O mouth resources to complete the control. The system supports text, pictures display of 256 grayscale

  14. Superluminal warp drive

    International Nuclear Information System (INIS)

    In this Letter we consider a warp drive spacetime resulting from that suggested by Alcubierre when the spaceship can only travel faster than light. Restricting to the two dimensions that retains most of the physics, we derive the thermodynamic properties of the warp drive and show that the temperature of the spaceship rises up as its apparent velocity increases. We also find that the warp drive spacetime can be exhibited in a manifestly cosmological form

  15. Led-valaistuksen soveltuvuus merentutkimusalus Arandalle

    OpenAIRE

    Vesterinen, Elina

    2015-01-01

    Opinnäytetyön tavoitteena oli selvittää led-valaistuksen soveltuvuutta merentutki-musalus Arandalle, sekä laivaolosuhteisiin yleisesti. Työssä selvitettiin led-valaistuksen mahdollisia energian säästöjä Arandan tämänhetkiseen valaistukseen verrattuna ja tarkasteltiin led-valaistuksen hyviä ja huonoja ominaisuuksia. Sekä led-valaistuksen ominaisuuksien, että luokituslaitosten säädösten perusteella pyrittiin arviomaan led-valaistuksen yleistä soveltuvuutta laivaolosuhteisiin. Lähdeainei...

  16. Modeling of single-event upset in bipolar integrated circuits

    Science.gov (United States)

    Zoutendyk, J. A.

    1983-01-01

    The results of work done on the quantitative characterization of single-event upset (SEU) in bipolar random-access memories (RAMs) have been obtained through computer simulation of SEU in RAM cells that contain circuit models for bipolar transistors. The models include current generators that emulate the charge collected from ion tracks. The computer simulation results are compared with test data obtained from a RAM in a bipolar microprocessor chip. This methodology is applicable to other bipolar integrated circuit constructions in addition to RAM cells.

  17. Family Environment and Suicidal Ideation Among Bipolar Youth

    Science.gov (United States)

    Goldstein, Tina R.; Birmaher, Boris; Axelson, David; Goldstein, Benjamin I.; Gill, Mary Kay; Esposito-Smythers, Christianne; Ryan, Neal D.; Strober, Michael A.; Hunt, Jeffrey; Keller, Martin

    2010-01-01

    The objective of this study was to examine the association between family environment and suicidal ideation among youth with bipolar disorder. Subjects included 446 bipolar (BP) youth (age 7–17) enrolled in the Course and Outcome of Bipolar Youth study. Current suicidal ideation, family functioning and family stress were assessed at intake. BP youth with current suicidal ideation reported more conflict with their mother and less family adaptability. Ideators endorsed more stressful family events over the prior year and higher rates of specific familial stressors. Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss. PMID:19813115

  18. Assessment of basic symptoms in schizophrenia, schizoaffective and bipolar disorders.

    Science.gov (United States)

    Ricca, V; Galassi, F; La Malfa, G; Mannucci, E; Barciulli, E; Cabras, P L

    1997-01-01

    In order to evaluate the basic symptoms differences of schizophrenics, schizoaffectives and bipolar patients, a consecutive series of 72 outpatients participated in the study. According to DSM III-R criteria, 28 had a diagnosis of schizophrenia, 29 of bipolar disorder and 15 of schizoaffective disorder. The assessment of basic symptoms was performed using the Frankfurter Beschwerde-Fragebogen (FBF). Data obtained suggest that perception and thought disturbances are the most characteristic experiences of schizophrenic patients in comparison with bipolar patients. The FBF questionnaire did not highlight a characteristic basic symptoms profile of schizoaffective disorder, when compared with bipolar affective disorder and schizophrenia. PMID:9042683

  19. Universal Drive Train Facility

    Data.gov (United States)

    Federal Laboratory Consortium — This vehicle drive train research facility is capable of evaluating helicopter and ground vehicle power transmission technologies in a system level environment. The...

  20. Antidepressants for bipolar disorder: A meta-analysis of randomized, double-blind, controlled trials

    OpenAIRE

    Zhang, Yingli; Yang, Huan; Yang, Shichang; Liang, Wei; DAI, Ping; Wang, Changhong; Zhang, Yalin

    2013-01-01

    OBJECTIVE: To examine the efficacy and safety of short-term and long-term use of antidepressants in the treatment of bipolar disorder. DATA SOURCES: A literature search of randomized, double-blind, controlled trials published until December 2012 was performed using the PubMed, ISI Web of Science, Medline and Cochrane Central Register of Controlled Trials databases. The keywords “bipolar disorder, bipolar I disorder, bipolar II disorder, bipolar mania, bipolar depression, cyclothymia, mixed ma...

  1. The Mood Disorder Questionnaire: A Simple, Patient-Rated Screening Instrument for Bipolar Disorder

    OpenAIRE

    Hirschfeld, Robert M. A.

    2002-01-01

    Bipolar disorder is frequently encountered in primary care settings, often in the form of poor response to treatment for depression. Although lifetime prevalence of bipolar I disorder is 1%, the prevalence of bipolar spectrum disorders (e.g., bipolar I, bipolar II, and cyclothymia) is much higher, especially among patients with depression. The consequences of misdiagnosis can be devastating. One way to improve recognition of bipolar spectrum disorders is to screen for them. The Mood Disorder ...

  2. Bipolar Fuzzy Soft sets and its applications in decision making problem

    OpenAIRE

    Aslam, Muhammad; Abdullah, Saleem; ullah, Kifayat

    2013-01-01

    In this article, we combine the concept of a bipolar fuzzy set and a soft set. We introduce the notion of bipolar fuzzy soft set and study fundamental properties. We study basic operations on bipolar fuzzy soft set. We define exdended union, intersection of two bipolar fuzzy soft set. We also give an application of bipolar fuzzy soft set into decision making problem. We give a general algorithm to solve decision making problems by using bipolar fuzzy soft set.

  3. Plant growth with Led lighting systems

    International Nuclear Information System (INIS)

    Leds lighting is highly relevant for the horticultural industry. Compared to other light sources used for plant production, leds have several properties which are potentially useful in relation to horticulture. However, although LEDs technology has raised strong interest in research for extraterrestrial agriculture, current LEDs panel costs are still too high for commercial adoption in greenhouse sector, and their electrical efficacies do not compete with those of high-pressure sodium lamps, but several manufactures are working to address these issues. When LEDs become practical, their ability to based light sources specifically suitable for photosynthesis and other horticulturally relevant plant properties (i.e. low radiated heat; lighting from within the canopy) will render the narrow band spectrum of LEDs of particular interest for providing light to greenhouse horticulture. A general description of LEDs application and their technical characteristics is briefly reported.

  4. A Color LED Driver Implemented by the Active Clamp Forward Converter

    OpenAIRE

    C. H. Chang; Cheng, H L; C. A. Cheng; E. C. Chang

    2013-01-01

    Because light emitting diodes (LEDs) have the advantages of dc working voltage, high luminescent efficiency, shortignition time, high reliability and pollution free, they have substituted for incandescent bulbs and fluorescent lampsgradually. In order to simplify circuit complexity, an active clamp forward converter with the sequential color display(SCD) control is proposed to drive red, green and blue (RGB) LED arrays. The proposed converter has zero-voltageswitching (ZVS) operations of both...

  5. Abordagens psicoterápicas no transtorno bipolar Psychoterapeutic approach in bipolar disorder

    OpenAIRE

    Paulo Knapp; Luciano Isolan

    2005-01-01

    Embora o tratamento farmacológico seja essencial para o tratamento do transtorno bipolar, apenas 40% de todos os pacientes que aderem às medicações permanecem assintomáticos durante o período de seguimento, o que tem levado ao desenvolvimento de intervenções psicoterápicas associadas. O objetivo deste artigo é examinar as evidências atuais da eficácia de intervenções psicoterápicas no tratamento do transtorno bipolar. Foi realizada uma pesquisa bibliográfica por meio do MedLine, PsychoINFO, L...

  6. Tratamento da depressão bipolar The treatment of bipolar depression

    OpenAIRE

    Beny Lafer; Marcia Britto de Macedo Soares

    2005-01-01

    O tratamento da depressão bipolar tem sido tema de debate. O uso de antidepressivos, principalmente tricíclicos, nestes pacientes está associado a piores desfechos clínicos. Estudos apontam para uma eficácia limitada de estabilizadores tradicionais como lítio, valproato e carbamazepina no tratamento da depressão bipolar. Em casos de depressão mais grave, há indicativos de que os antidepressivos podem ser úteis, sendo recomendado o uso concomitante de um estabilizador do humor. Novos agentes c...

  7. Implementation of PIC Based LED Displays

    Directory of Open Access Journals (Sweden)

    Htet Htet Thit San

    2014-09-01

    Full Text Available This paper explains the project which is a special kind of LED Display Board for performing dance movement according to the rhythm of music. Nowadays, LED display boards are widely used in advertising and other applications. LED display boards can also be used indoors or outdoors. The objective of this system is to design a display panel by using several dozens of LED matrix display. The display pattern can desire to be changed easily and modified by the user. This LED display board is overall in two major components; which are the microcontroller and LED display panel. Microcontrollers with programs are developed to generate characters and graphics for this module. In this system, when the LED display board is “ON”, it will display the messages and then dance movements by the rhythm of music using a PIC microcontroller. It is not needed to change the LED panel, only to change the input data in PIC program. In this system, LED panel is controlled by a program in microcontroller from serial to parallel shift registers using the scanning method. PIC microcontroller is for generating the output signal to output display board by using a program. Then, it will be run on the LED display board. This is very useful in area like railway platforms, streets, banks, training institutes and other applications to show data information on the large LED boards. As a result, this LED display board is useful as indoors or outdoors as it is also economic. This display consists of maximum 72 bright LEDs which are rotated to show the display. In this system, this display can show data information which will require a whopping 512 LEDs. Therefore hardware and cost minimization is achieved. PIC Basic Pro programming language will be used in PIC microcontroller. The simulation result will be tested with Proteus 8 Electronic Simulation Software.

  8. Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse.

    OpenAIRE

    Yang, X. L.; S. M. Wu

    1991-01-01

    Lateral inhibition is the ubiquitous strategy used by visual neurons for spatial resolution throughout the animal kingdom. It has been a puzzle whether lateral inputs in retinal bipolar cells are mediated by the horizontal cell (HC)-cone feedback synapse, by the HC-bipolar cell feedforward synapse, or by both. By blocking the central inputs of the depolarizing bipolar cells (DBCs) with L-2-amino-4-phosphonobutyrate, we were able to eliminate the contribution of the feedback synapse and to dem...

  9. Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder

    OpenAIRE

    Tzu-Yun Wang; Sheng-Yu Lee; Shiou-Lan Chen; Yun-Hsuan Chang; Liang-Jen Wang; Po See Chen; Shih-Heng Chen; Chun-Hsien Chu; San-Yuan Huang; Nian-Sheng Tzeng; Chia-Ling Li; Yi-Lun Chung; Tsai-Hsin Hsieh; I Hui Lee; Kao Chin Chen

    2016-01-01

    Patients with subthreshold hypomania (SBP; subthreshold bipolar disorder) were indistinguishable from those with bipolar disorder (BP)-II on clinical bipolar validators, but their analyses lacked biological and pharmacological treatment data. Because inflammation and neuroprogression underlies BP, we hypothesized that cytokines and brain-derived neurotrophic factor (BDNF) are biomarkers for BP. We enrolled 41 drug-naïve patients with SBP and 48 with BP-II undergoing 12 weeks of pharmacologica...

  10. Late Onset Bipolar Disorder due to a Lacunar State

    Directory of Open Access Journals (Sweden)

    Elena Antelmi

    2014-01-01

    Full Text Available Objective. To describe a patient with a new onset bipolar disorder (BD type II, secondary to a lacunar state. Background. Poststroke BD is rare and mainly associated with lesion in the prefrontal-striatal-thalamic circuit. Materials and Methods. A 51-year-old woman came to our attention for a mood disorder of recent onset. At 49, she had suffered acute left-sided limb weakness that improved spontaneously four days later. Arterial hypertension was subsequently diagnosed. After 6 months, she began to suffer from alternating brief periods of expansive and elevated mood with longer periods of depressed mood, with a suicide attempt. We performed extensive laboratory and instrumental investigations, as well as, psychiatric consultation, and a cognitive assessment, which was repeated 9 months later. Results. Brain magnetic resonance disclosed leukoaraiosis and a lacunar state of the basal ganglia. Transcranial Doppler showed a patent foramen ovale. A psychiatric consultation led to the diagnosis of BP type II. Neuropsychological evaluation detected deficits in attention/executive functions, verbal fluency, and memory. Nine months later, after specific psychiatric therapy, the psychiatric symptoms were remarkably improved. Conclusion. Our case sheds light on the role of the basal ganglia in mood disorders and the importance of ruling out brain injury in late onset BP.

  11. Análise da eficiência energética, ambiental e econômica entre lâmpadas de LED e convencionais

    OpenAIRE

    Talía Simões dos Santos; Marília Carone Batista; Simone Andréa Pozza; Luciana Savoi Rossi

    2015-01-01

    RESUMO Os Diodos Emissores de Luz, mais conhecidos como LED's, são componentes eletrônicos semicondutores que conseguem transformar a energia elétrica em luz, diferente das lâmpadas convencionais. O LED é um componente bipolar, que quando passa corrente elétrica, a luz é gerada. As lâmpadas modernas utilizam LED em sua formação, as quais liberam menos calor e utilizam menos energia, sendo assim mais econômicas que as incandescentes e as fluorescentes. Além de apresentarem maior durabilidade q...

  12. Flexible resonant tank for a combined converter to achieve an HPS and LED compatible driver

    Institute of Scientific and Technical Information of China (English)

    Jin HU; Hui-pin LIN; Zheng-yu LU; Feng-wu ZHOU

    2015-01-01

    High pressure sodium (HPS) lamp has been widely used in street lighting applications because of its maturity, relia-bility, high lighting efficiency, long life-time, and low cost. Light emitting diode (LED) is expected as the next generation lighting source due to its continuously improving luminous efficacy, better color characteristic, and super long life-time. The two lighting sources may coexist in street lighting applications for a long time. A novel HPS and LED compatible driver is proposed which is rather suitable and flexible for driving HPS and LED in street lighting applications. The proposed driver combines the LLC and LCC resonant circuits into a flexible resonant tank. The flexible resonant tank may change to LLC or isolated LCC circuit ac-cording to the lighting source. It inherits the traditional HPS and LED drivers’ zero voltage switching (ZVS) characteristics and dimmable function. The design of the proposed flexible resonant tank considers the requirements of both HPS and LED. The experiments of driving HPS and LED on a prototype driver show that the driver can drive the two lighting sources flexibly with high efficiency.

  13. Testing Finance-Led, Export-Led and Import-Led Growth Hypotheses on Four Sub-Saharan African Economies

    OpenAIRE

    Evans, Olaniyi

    2013-01-01

    This study carries out an empirical examination of the finance-led, export-led and import-led growth hypothesis for four of the largest Sub-Saharan African economies namely South Africa, Nigeria, Ghana and Kenya. Within a multivariate Vector-Auto Regressive (VAR) framework, the concept of Granger causality is employed to determine the direction of causation between exports and output, duly taking into account the stationarity properties of the time series data. With further substantiation fro...

  14. Piezoelectric drive circuit

    Science.gov (United States)

    Treu, Jr., Charles A.

    1999-08-31

    A piezoelectric motor drive circuit is provided which utilizes the piezoelectric elements as oscillators and a Meacham half-bridge approach to develop feedback from the motor ground circuit to produce a signal to drive amplifiers to power the motor. The circuit automatically compensates for shifts in harmonic frequency of the piezoelectric elements due to pressure and temperature changes.

  15. Fundamentals of electrical drives

    CERN Document Server

    Veltman, André; De Doncker, Rik W

    2007-01-01

    Provides a comprehensive introduction to various aspects of electrical drive systems. This volume provides a presentation of dynamic generic models that cover all major electrical machine types and modulation/control components of a drive as well as dynamic and steady state analysis of transformers and electrical machines.

  16. Electric Vehicle - Economical driving

    DEFF Research Database (Denmark)

    Jensen, VCE, Steen V.; Schøn, Henriette

    1999-01-01

    How do you reduce the energy-wast when driving and loading EV's - or rather: How do I get more km/l out of an EV......How do you reduce the energy-wast when driving and loading EV's - or rather: How do I get more km/l out of an EV...

  17. Design of one large telescope direct drive control system based on TMS320F28xx

    Science.gov (United States)

    Song, Xiao-li; Wang, Da-xing; Zhang, Chao; Zhang, Zhen-chao; Chen, Li-yan; Ren, Chang-zhi

    2014-08-01

    The mount drive control is the key technique which mostly affects astronomical telescope's resolution and its speed. However, the ultra -lower speed and the giant moment of inertia make it very difficult to be controlled. In this paper, one segmented permanent-magnet synchronous motor (PMSM), 4m diameter, is suggested for the mount driving. A method is presented to drive the motor directly, which is based on TMS320F28XX and Insulated Gate Bipolar Transistor (IGBT) , also, HEIDENHAIN tape is used to detect the absolute position of the motor together with the Hall sensor. The segmented PMSM can work stable and the mount drive can realize nice tracking performance at ultra -lower speed with this drive system.

  18. Semiclassical instability of dynamical warp drives

    International Nuclear Information System (INIS)

    Warp drives are very interesting configurations in general relativity: At least theoretically, they provide a way to travel at superluminal speeds, albeit at the cost of requiring exotic matter to exist as solutions of Einstein's equations. However, even if one succeeded in providing the necessary exotic matter to build them, it would still be necessary to check whether they would survive to the switching on of quantum effects. Semiclassical corrections to warp-drive geometries have been analyzed only for eternal warp-drive bubbles traveling at fixed superluminal speeds. Here, we investigate the more realistic case in which a superluminal warp drive is created out of an initially flat spacetime. First of all we analyze the causal structure of eternal and dynamical warp-drive spacetimes. Then we pass to the analysis of the renormalized stress-energy tensor (RSET) of a quantum field in these geometries. While the behavior of the RSET in these geometries has close similarities to that in the geometries associated with gravitational collapse, it shows dramatic differences too. On one side, an observer located at the center of a superluminal warp-drive bubble would generically experience a thermal flux of Hawking particles. On the other side, such Hawking flux will be generically extremely high if the exotic matter supporting the warp drive has its origin in a quantum field satisfying some form of quantum inequalities. Most of all, we find that the RSET will exponentially grow in time close to, and on, the front wall of the superluminal bubble. Consequently, one is led to conclude that the warp-drive geometries are unstable against semiclassical backreaction.

  19. ‘No Blue’ White LED

    DEFF Research Database (Denmark)

    Ou, Haiyan; Corell, Dennis Dan; Dam-Hansen, Carsten;

    2010-01-01

    . Gretagmacbeth color charts were used as a more visual way to compare the two light sources, which shows that our no-blue LED bulb has much better color rendering ability than the YFT. Furthermore, LED solution has design flexibility to improve it further. The prototype has been tested with photoresist SU8......This paper explored the feasibility of making a white LED light source by color mixing method without using the blue color. This ‘no blue’ white LED has potential applications in photolithography room illumination, medical treatment and biophotonics research. A no-blue LED was designed......, and the prototype was fabricated. The spectral power distribution of both the LED bulb and the yellow fluorescent tube was measured. Based on that, colorimetric values were calculated and compared on terms of chromatic coordinates, correlated color temperature, color rendering index, and chromatic deviation...

  20. Neurocognitive profiles in treatment-resistant bipolar I and bipolar II disorder depression

    OpenAIRE

    Kessler, Ute; Schøyen, Helle Kristine; Andreassen, Ole Andreas; Eide, Geir Egil; Hammar, Åsa; Malt, Ulrik Fredrik; Ødegaard, Ketil Joachim; Morken, Gunnar; Sundet, Kjetil Søren; Vaaler, Arne Einar

    2013-01-01

    Background The literature on the neuropsychological profiles in Bipolar disorder (BD) depression is sparse. The aims of the study were to assess the neurocognitive profiles in treatment-resistant, acutely admitted BD depression inpatients, to compare the neurocognitive functioning in patients with BD I and II, and to identify the demographic and clinical illness characteristics associated with cognitive functioning. Met...

  1. System Reliability for LED-Based Products

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J Lynn; Mills, Karmann; Lamvik, Michael; Yaga, Robert; Shepherd, Sarah D; Bittle, James; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy; Johnson, Cortina; Evans, Amy

    2014-04-07

    Results from accelerated life tests (ALT) on mass-produced commercially available 6” downlights are reported along with results from commercial LEDs. The luminaires capture many of the design features found in modern luminaires. In general, a systems perspective is required to understand the reliability of these devices since LED failure is rare. In contrast, components such as drivers, lenses, and reflector are more likely to impact luminaire reliability than LEDs.

  2. LEDs for general and horticultural lighting

    OpenAIRE

    Girón González, Emilio

    2012-01-01

    The work begins with an introductory part about Light Emitting Diode (or LEDs) and how these devices work. This report also shows an overview of different artificial light sources such as incandescent lamps, fluorescents tube and high-intensity discharge (HID) lamps. The LED lighting is more energy-efficient than other artificial lighting, since they require less energy to operate. The following part of the work reports LEDs for General Lighting that describes some basic concepts such as spec...

  3. Wide reflected angle DBR red light LED

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The coupled DBR LED with one DBR for reflecting normal incidence light and the other for reflecting inclined incidence light has been grown by MOCVD. For improving the conventional DBR which was used to increase light extraction efficiency in A1GaInP red light LED is analyzed. At 20 mA Dc injection current, the LED peak wave length is 630 nm, and the light intensity of on axis is 137 mcd. The output light power is 2.32 mW. The light intensity and output light power have been improved compared with the conventional LEDs.

  4. Life-Cycle Assessment of Energy and Environmental Impacts of LED Lighting Products, Part 3: LED Environmental Testing

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, Jason R.; Hollomon, Brad; Dillon, Heather E.; Snowden-Swan, Lesley J.

    2013-03-01

    This report covers the third part of a larger U.S. Department of Energy (DOE) project to assess the life-cycle environmental and resource impacts in the manufacturing, transport, use, and disposal of light-emitting diode (LED) lighting products in relation to incumbent lighting technologies. All three reports are available on the DOE website (www.ssl.energy.gov/tech_reports.html). • Part 1: Review of the Life-Cycle Energy Consumption of Incandescent, Compact Fluorescent and LED Lamps; • Part 2: LED Manufacturing and Performance; • Part 3: LED Environmental Testing. Parts 1 and 2 were published in February and June 2012, respectively. The Part 1 report included a summary of the life-cycle assessment (LCA) process and methodology, provided a literature review of more than 25 existing LCA studies of various lamp types, and performed a meta-analysis comparing LED lamps with incandescent and compact fluorescent lamps (CFLs). Drawing from the Part 1 findings, Part 2 performed a more detailed assessment of the LED manufacturing process and used these findings to provide a comparative LCA taking into consideration a wider range of environmental impacts. Both reports concluded that the life-cycle environmental impact of a given lamp is dominated by the energy used during lamp operation—the upstream generation of electricity drives the total environmental footprint of the product. However, a more detailed understanding of end-of-life disposal considerations for LED products has become increasingly important as their installation base has grown. The Part 3 study (reported herein) was undertaken to augment the LCA findings with chemical analysis of a variety of LED, CFL, and incandescent lamps using standard testing procedures. A total of 22 samples, representing 11 different models, were tested to determine whether any of 17 elements were present at levels exceeding California or Federal regulatory thresholds for hazardous waste. Key findings include: • The selected

  5. Depressive Episode May Not Always Follow Mania in Bipolar Disorder

    Science.gov (United States)

    ... 5.7 million Americans have bipolar disorder, which causes cycles of mania (elevated or irritable mood) and depression. The new findings stem from an analysis of data from more than 34,000 American adults with bipolar disorder. "Although it has long been ...

  6. SEMICLASSICAL LIMIT FOR BIPOLAR QUANTUM DRIFT-DIFFUSION MODEL

    Institute of Scientific and Technical Information of China (English)

    Ju Qiangchang; Chen Li

    2009-01-01

    Semiclassical limit to the solution of transient bipolar quantum drift-diffusion model in semiconductor simulation is discussed. It is proved that the semiclassical limit ofthis solution satisfies the classical bipolar drift-diffusion model. In addition, the authors also prove the existence of weak solution.

  7. Cognitive-Behavioral Therapy for Rapid Cycling Bipolar Disorder

    Science.gov (United States)

    Reilly-Harrington, Noreen A.; Knauz, Robert O.

    2005-01-01

    This article describes the application of cognitive-behavioral therapy (CBT) to the treatment of rapid cycling bipolar disorder. Between 10% and 24% of bipolar patients experience a rapid cycling course, with 4 or more mood episodes occurring per year. Characterized by nonresponse to standard mood-stabilizing medications, rapid cyclers are…

  8. Risperidone Mono - Therapy as Prophylaxis in Bipolar Affective Disorders

    OpenAIRE

    Trivedi, Mohit; Pinto, Denzil; Safeekh, A.T.

    2004-01-01

    Risperidone has been found to be useful in the treatment of acute bipolar disorders. This is a case report where risperidone mono therapy has been found to be effective in prophylaxis of bipolar affective disorder. The pharmacological and clinical implications of risperidone in the management of BPAD are discussed

  9. Pharmacological Management of Bipolar Disorder in a Youth with Diabetes

    Science.gov (United States)

    DelBello, Melissa P.; Correll, Christoph U.; Carlson, Gabrielle A.; Carlson, Harold E.; Kratochvil, Christopher J.

    2007-01-01

    In this article, four clinicians respond to the following case vignette: A 12-year-old girl with insulin-dependent diabetes presents for treatment of her newly diagnosed bipolar disorder. How would you address the bipolar disorder pharmacologically, and how would the presence of diabetes affect your selection of medication and clinical management?

  10. Commentary: Treatment Guidelines for Child and Adolescent Bipolar Disorder

    Science.gov (United States)

    McClellan, Jon

    2005-01-01

    Once considered rare in children, pediatric bipolar disorder is now widely diagnosed in the United States. The illness has become a cultural phenomenon, adorning the cover of Time magazine and headlining national news broadcasts. Kowatch and colleagues, in compiling consensus recommendations for bipolar disorder in children and adolescents, have…

  11. The Enigma of Bipolar Disorder in Children and Adolescents

    Science.gov (United States)

    Hatchett, Gregory T.

    2009-01-01

    In the past decade, there has been a proliferation in the number of children and adolescents diagnosed with bipolar disorder. Except in rare cases, the young people who receive this diagnosis do not meet the strict diagnostic criteria for bipolar disorder I or II in the DSM-IV-TR. Many pediatric psychiatrists insist there are important development…

  12. Olfactocentric Paralimbic Cortex Morphology in Adolescents with Bipolar Disorder

    Science.gov (United States)

    Wang, Fei; Kalmar, Jessica H.; Womer, Fay Y.; Edmiston, Erin E.; Chepenik, Lara G.; Chen, Rachel; Spencer, Linda; Blumberg, Hilary P.

    2011-01-01

    The olfactocentric paralimbic cortex plays a critical role in the regulation of emotional and neurovegetative functions that are disrupted in core features of bipolar disorder. Adolescence is thought to be a critical period in both the maturation of the olfactocentric paralimbic cortex and in the emergence of bipolar disorder pathology. Together,…

  13. Bipolar Disorder in Children: Implications for Speech-Language Pathologists

    Science.gov (United States)

    Quattlebaum, Patricia D.; Grier, Betsy C.; Klubnik, Cynthia

    2012-01-01

    In the United States, bipolar disorder is an increasingly common diagnosis in children, and these children can present with severe behavior problems and emotionality. Many studies have documented the frequent coexistence of behavior disorders and speech-language disorders. Like other children with behavior disorders, children with bipolar disorder…

  14. Pediatric Bipolar Disorder: Evidence for Prodromal States and Early Markers

    Science.gov (United States)

    Luby, Joan L.; Navsaria, Neha

    2010-01-01

    Background: Childhood bipolar disorder remains a controversial but increasingly diagnosed disorder that is associated with significant impairment, chronic course and treatment resistance. Therefore, the search for prodromes or early markers of risk for later childhood bipolar disorder may be of great importance for prevention and/or early…

  15. Bipolar Disorder: not only in the Brain - immunological aspects

    NARCIS (Netherlands)

    E.M. Knijff (Esther)

    2006-01-01

    textabstractThe main objective of this thesis was to obtain more insight in the role of the immune system in the pathogenesis of bipolar disorder by investigating various aberrancies in the immune system of patients with bipolar disorder. In Chapter 1 some general concepts, important for the per

  16. The Ebers-Moll model for magnetic bipolar transistors

    OpenAIRE

    Fabian, J.; Zutic, I.

    2004-01-01

    The equivalent electrical circuit of the Ebers-Moll type is introduced for magnetic bipolar transistors. In addition to conventional diodes and current sources, the new circuit comprises two novel elements due to spin-charge coupling. A classification scheme of the operating modes of magnetic bipolar transistors in the low bias regime is presented.

  17. Polygenic risk scores for schizophrenia and bipolar disorder predict creativity

    NARCIS (Netherlands)

    Power, R.A.; Steinberg, S.; Bjornsdottir, G.; Rietveld, C.A.; Abdellaoui, A.; Nivard, M.M.; Johannesson, M.; Galesloot, T.E.; Hottenga, J.J.; Willemsen, G.; Cesarini, D.; Benjamin, D.J.; Magnusson, P.K.; Ullen, F.; Tiemeier, H.; Hofman, A.; Rooij, F.J. van; Walters, G.B.; Sigurdsson, E.; Thorgeirsson, T.E.; Ingason, A.; Helgason, A.; Kong, A.; Kiemeney, B.; Koellinger, P.; Boomsma, D.I.; Gudbjartsson, D.; Stefansson, H.; Stefansson, K.

    2015-01-01

    We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 x 10(-6) and 3.8 x 10(-6) for schizophrenia and bipolar disorder scores, respectiv

  18. The Relationship Between Bipolar Disorder, Seasonality, and Premenstrual Symptoms

    OpenAIRE

    Kim, Deborah R.; Czarkowski, Kathryn A.; Epperson, C. Neill

    2011-01-01

    Cyclical mood disorders characterized by shifting affective states include bipolar disorder, seasonal affective disorder, and premenstrual syndrome/premenstrual dysphoric disorder. In this article, we explore the relationship between these disorders and bring the reader up to date on the advances made in the past year in understanding the relationship between bipolar disorder, seasonality, and premenstrual symptoms.

  19. The CBCL Bipolar Profile and Attention, Mood, and Behavior Dysregulation

    Science.gov (United States)

    Doerfler, Leonard A.; Connor, Daniel F.; Toscano, Peter F.

    2011-01-01

    Biederman and colleagues reported that a CBCL profile identified youngsters who were diagnosed with bipolar disorder. Some studies found that this CBCL profile does not reliably identify children who present with bipolar disorder, but nonetheless this CBCL does identify youngsters with severe dysfunction. However, the nature of the impairment of…

  20. Cortisol exposure, cognition and clinical course of bipolar disorder

    NARCIS (Netherlands)

    Spijker, Anne Titia

    2012-01-01

    In this dissertation, we aimed to identify the influence of cortisol exposure and cognitive performance on the clinical course of bipolar disorder. Data regarding sociodemographics, disease characteristics and genetic analysis of the cortisol receptors, were collected of 366 patients with bipolar d

  1. [Obesity and dyslipidemia in Tunisian bipolar subjects].

    Science.gov (United States)

    Ezzaher, Asma; Haj Mouhamed, Dhouha; Mechri, Anwar; Neffati, Fadoua; Douki, Wahiba; Gaha, Lotfi; Najjar, Mohamed Fadhel

    2010-01-01

    This study aims to investigate the prevalence of obesity and overweight and their association with lipid parameters in bipolar patients. Our study included 130 patients with bipolar disorder and 130 control subjects aged respectively 37.9 +/- 12.1 and 37.2 +/- 13.1 years. Obesity was evaluated by body mass index (BMI). Concentrations of total cholesterol, triglycerides, cLDL and cHDL were determined by enzymatic methods and ApoA1, ApoB and Lp(a) by techniques immunoturbidimetric. The prevalence of obesity in patients is 30.1% vs 12.3% in controls. A significant increase in BMI was noted in patients compared with controls regardless of sex and tobacco status and in patients aged less than 35 years and those consumers of alcohol. The majority of obese and overweight patients are treated with valproic acid. We found increase in cholesterol (4.41 +/- 1.02 vs 3.90 +/- 0.98 mmol/L), in cLDL (2.13 +/- 1.09 vs 1.29 +/- 0.56 mmol/L) and in Lp(a) (236 +/- 207 vs 163 +/- 150 mg/L) and decrease in HDLc (0.98 +/- 0.28 vs 1.09 +/- 0.36 mmol/L), more frequent at the obese patients and those presenting an overweight. In conclusion, in bipolar patients, obesity and overweight are frequent and associated with perturbations in lipid profile particularly an increase in total cholesterol, cLDL and Lp(a) and decrease in cHDL that increase the risk of cardiovascular disease. PMID:20478770

  2. Bipolar Saline TURP for Large Prostate Glands

    Directory of Open Access Journals (Sweden)

    David S. Finley

    2007-01-01

    Full Text Available The objective of this study was to evaluate the feasibility of bipolar transurethral resection of the prostate (TURP in patients with very large prostate glands and significant comorbidities. Four patients with prostate glands >160 cc on preoperative volume measurement and ASA class three or higher underwent bipolar TURP with the Gyrus PlasmaKinetic system. Preoperative, operative, and postoperative parameters were studied. The results showed an average ASA class 3.25 (range: 3–4. The average preoperative prostate volume was 207.4 cc (range: 163–268. The average preoperative International Prostate Symptom Score (IPSS and bother score was 31 and 6, respectively. Mean resection time was 163 min (range: 129–215. The weight of resected tissue and percentage of vaporized tissue was 80.8 g (range: 62–115 and 10.0% (range: 3.8–15.1, respectively. An average of 61L of saline was used (range: 48–78. The mean change in hemoglobin and serum sodium was 2.1 g/dl (range: 1.4–2.7 and 3.3 meq/l (range: 2–4, respectively. Postoperative catheter time averaged 76 h (range: 40–104. Mean length of hospital stay was 12 h (range: 4–24. The mean postoperative IPSS and bother score was 2.75 and 0.25, respectively. Bipolar TURP is a feasible alternative to simple open prostatectomy in high-risk patients with massive prostate adenomas. Prostate volume is reduced by approximately 10% due to vaporization.

  3. Does bipolar pacemaker current activate blood platelets?

    DEFF Research Database (Denmark)

    Gjesdal, Grunde; Hansen, Annebirthe Bo; Brandes, Axel

    2009-01-01

    platelets and muscle cells contain actin and myosin filaments, and both cells are activated following calcium influx. Muscle cells open their calcium channels and contract when exposed to an electric current. Current through a bipolar pacemaker lead will expose a small volume of blood, including platelets......, to the depolarizing current. Platelet activation may ensue, resulting in aggregation, release reaction, and contraction. In contrast, a unipolar pacemaker system will not depolarize blood, but transmit current directly into the myocardium, and the current afterward passes through other tissues before...

  4. Animal models of recurrent or bipolar depression.

    Science.gov (United States)

    Kato, T; Kasahara, T; Kubota-Sakashita, M; Kato, T M; Nakajima, K

    2016-05-01

    Animal models of mental disorders should ideally have construct, face, and predictive validity, but current animal models do not always satisfy these validity criteria. Additionally, animal models of depression rely mainly on stress-induced behavioral changes. These stress-induced models have limited validity, because stress is not a risk factor specific to depression, and the models do not recapitulate the recurrent and spontaneous nature of depressive episodes. Although animal models exhibiting recurrent depressive episodes or bipolar depression have not yet been established, several researchers are trying to generate such animals by modeling clinical risk factors as well as by manipulating a specific neural circuit using emerging techniques. PMID:26265551

  5. A new bipolar Qtrim power supply system

    International Nuclear Information System (INIS)

    This year marks the 15th run of RHIC (Relativistic Heavy Ion Collider) operations. The reliability of superconducting magnet power supplies is one of the essential factors in the entire accelerator complex. Besides maintaining existing power supplies and their associated equipment, newly designed systems are also required based on the physicist@s latest requirements. A bipolar power supply was required for this year@s main quadruple trim power supply. This paper will explain the design, prototype, testing, installation and operation of this recently installed power supply system.

  6. A new bipolar Qtrim power supply system

    Energy Technology Data Exchange (ETDEWEB)

    Mi, C. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Bruno, D. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Drozd, J. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Nolan, T. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Orsatti, F. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Heppener, G. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Di Lieto, A. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Schultheiss, C. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Samms, T. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Zapasek, R. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.; Sandberg, J. [Brookhaven National Lab. (BNL), Upton, NY (United States). Collider-Accelerator Dept.

    2015-05-03

    This year marks the 15th run of RHIC (Relativistic Heavy Ion Collider) operations. The reliability of superconducting magnet power supplies is one of the essential factors in the entire accelerator complex. Besides maintaining existing power supplies and their associated equipment, newly designed systems are also required based on the physicist’s latest requirements. A bipolar power supply was required for this year’s main quadruple trim power supply. This paper will explain the design, prototype, testing, installation and operation of this recently installed power supply system.

  7. Dose Rate Effects in Linear Bipolar Transistors

    Science.gov (United States)

    Johnston, Allan; Swimm, Randall; Harris, R. D.; Thorbourn, Dennis

    2011-01-01

    Dose rate effects are examined in linear bipolar transistors at high and low dose rates. At high dose rates, approximately 50% of the damage anneals at room temperature, even though these devices exhibit enhanced damage at low dose rate. The unexpected recovery of a significant fraction of the damage after tests at high dose rate requires changes in existing test standards. Tests at low temperature with a one-second radiation pulse width show that damage continues to increase for more than 3000 seconds afterward, consistent with predictions of the CTRW model for oxides with a thickness of 700 nm.

  8. Neurocognitive features in subgroups of bipolar disorder

    OpenAIRE

    Aminoff, Sofie Ragnhild; Hellvin, Tone; Lagerberg, Trine Vik; Berg, Akiah Ottesen; Andreassen, Ole A; Melle, Ingrid

    2013-01-01

    Objective To examine which subgroups of DSM-IV bipolar disorder (BD) [BD type I (BD-I) or BD type II (BD-II), and subgroups based on history of psychosis, presenting polarity, and age at onset] differentiate best regarding neurocognitive measures. Methods A total of 199 patients with BD were characterized by clinical and neurocognitive features. The distribution of subgroups in this sample was: BD-I, 64% and BD-II, 36%; 60% had a history of psychosis; 57% had depression as the presenting pola...

  9. Síntesis de sumadores bipolares

    OpenAIRE

    Mellado Rodríguez, E.; Alonso Rentería, Esther; Tarela Pereiro, José Manuel

    1982-01-01

    La clase de códigos denominada bipolar binaria incluye un amplio conjunto de códigos binarios con ciertas propiedades comunes. Este hecho, así como la circunstancia de que ciertos conjuntos de operadores funcionalmente completos que incluyen al EXOR facilitan la síntesis de funciones, se aplica a la obtención de sumadores generalizados tanto en el sentido de que aceptan más de dos entradas simultáneas como en el sentido de que éstas pudieran pertenecer a códigos diferentes. The class of co...

  10. International Society for Bipolar Disorders Task Force on Suicide

    DEFF Research Database (Denmark)

    Schaffer, Ayal; Isometsä, Erkki T; Tondo, Leonardo;

    2015-01-01

    suicide deaths in bipolar disorder. These findings do not address causation, and the heterogeneity of data sources should limit the direct clinical ranking of correlates. Our results nonetheless support the notion of incorporating diagnosis-specific data in the development of models of understanding......OBJECTIVES: Bipolar disorder is associated with a high risk of suicide attempts and suicide death. The main objective of the present study was to identify and quantify the demographic and clinical correlates of attempted and completed suicide in people with bipolar disorder. METHODS: Within the...... framework of the International Society for Bipolar Disorders Task Force on Suicide, a systematic review of articles published since 1980, characterized by the key terms bipolar disorder and 'suicide attempts' or 'suicide', was conducted, and data extracted for analysis from all eligible articles...

  11. State-related alterations of gene expression in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Berk, Michael;

    2012-01-01

    Munkholm K, Vinberg M, Berk M, Kessing LV. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord 2012: 14: 684-696. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Alterations in gene expression in bipolar disorder...... vulnerability pathways. This review therefore evaluated the evidence for whether gene expression in bipolar disorder is state or trait related. Methods:  A systematic review, using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline for reporting systematic reviews, based...... on comprehensive database searches for studies on gene expression in patients with bipolar disorder in specific mood states, was conducted. We searched Medline, Embase, PsycINFO, and The Cochrane Library, supplemented by manually searching reference lists from retrieved publications. Results:  A...

  12. Neurocognition as a stable endophenotype in bipolar disorder and schizophrenia.

    Science.gov (United States)

    Burdick, Katherine E; Goldberg, Joseph F; Harrow, Martin; Faull, Robert N; Malhotra, Anil K

    2006-04-01

    Linkage and association studies have paid increasing attention to neurocognition as a putative endophenotype. However, there exists little documentation of its trait stability in schizophrenia or bipolar disorder. Our aim was to determine the longitudinal stability of neurocognitive performance in bipolar versus schizophrenia probands. We administered a neurocognitive battery at two time points, approximately 5 years apart, in 16 schizophrenia and 16 bipolar disorder age-matched subjects. There were no significant changes over time on variables including education, estimated IQ, depression, psychosis, global functioning, or medication status. Schizophrenia subjects showed significant deterioration in one measure of executive functioning but no significant changes in seven of eight other domains. Bipolar patients showed stability over time in attentional measures but greater variability in other domains. These preliminary findings suggest that neurocognitive domains appear longitudinally stable across broad domains in schizophrenia. In contrast, stable functioning may be more limited to attentional domains in bipolar disorder. PMID:16614546

  13. Fast wave current drive

    Energy Technology Data Exchange (ETDEWEB)

    Goree, J.; Ono, M.; Colestock, P.; Horton, R.; McNeill, D.; Park, H.

    1985-07-01

    Fast wave current drive is demonstrated in the Princeton ACT-I toroidal device. The fast Alfven wave, in the range of high ion-cyclotron harmonics, produced 40 A of current from 1 kW of rf power coupled into the plasma by fast wave loop antenna. This wave excites a steady current by damping on the energetic tail of the electron distribution function in the same way as lower-hybrid current drive, except that fast wave current drive is appropriate for higher plasma densities.

  14. Driving When You Have Cataracts

    Science.gov (United States)

    ... when they want. I Driving is a complex skill. Our ability to drive safely can be challenged by changes in our ... drive with you to see how well you drive with your cataract. I The ... to improve your driving skills. Improving your skills could help keep you and ...

  15. Gender and Depressive Symptoms in 711 Patients With Bipolar Disorder Evaluated Prospectively in the Stanley Foundation Bipolar Treatment Outcome Network

    NARCIS (Netherlands)

    Altshuler, Lori L.; Kupka, Ralph W.; Hellemann, Gerhard; Frye, Mark A.; Sugar, Catherine A.; McElroy, Susan L.; Nolen, Willem A.; Grunze, Heinz; Leverich, Gabriele S.; Keck, Paul E.; Zermeno, Melanie

    2010-01-01

    Objective: The authors assessed gender differences in the proportion of clinical visits spent depressed, manic, or euthymic in patients with bipolar disorder. Method: Data were analyzed from 711 patients with bipolar I or II disorder who were followed prospectively over 7 years (13,191 visits). The

  16. LED illuminant on the ambient light

    Science.gov (United States)

    Liu, Anqing; Sandipan, Mishra; Shur, Michael

    2014-09-01

    We develop an approach for combining illuminance and spectral power distribution of the LED and ambient light and apply our technique for developing an LED camera flashlight balancing the illuminance contrast between object and background. Our method uses the closed loop, multiobjective optimization comprising: (1) characterizing the lighting task by illuminance, correlated color temperature (CCT), and statistical color quality indices that include a set of Statistical Color Quality Metrics and the Color Rendition Index (CRI) implemented with indexes of S (saturation) or D (dulling); (2) measuring the illuminance and the spectrum of the ambient light on the target lighting surface, which might depend on all the sources proving illumination and on the reflected light; (3) determining the desired illuminance of the LED source on the target lighting surface; (4) calculating the desired luminous flux of the LED source according to the desired illuminance; (5) constituting the SPD of the LED source; (6) calculating the relative spectra counts of the LED source and the ambient light on the target lighting surface (7) calculating the CCT and statistical color quality indexes of the combined light; (8) repeating the above steps until the resulting SPD is close enough to the expectation. Using the above method, an LED camera flashlight has been designed, which works together with usual fluorescent ambient light and generates working lighting environment with high fidelity and high CCT (6000K). The spectrum and luminous flux of the LED lamp is automatically tunable with a change of the ambient light.

  17. Led Zeppelin reklaamib Narvat / Anti Ronk

    Index Scriptorium Estoniae

    Ronk, Anti

    2007-01-01

    Ilmus Narva-teemaline kahest CD-st koosnev album, kus ühel plaadil on 60 minutit videot linna vaatamisväärsuste ja informatsiooniga, teisel - briti rockansambli Led Zeppelini teosed Narva sümfooniaorkestri ja rockansambli Led R esituses

  18. Led-licht biedt mogelijkheden in broeierij

    NARCIS (Netherlands)

    Neefjes, H.; PPO Bomen-bollen,

    2010-01-01

    Onderzoekers van PPO Lisse hebben de mogelijkheden van led-licht verkend bij met name lelie en tulp. Bij lelie bieden leds perspectief in de voortrek. Tulp kan er bijna de hele broeifase van profiteren. Veel licht is niet nodig, maar meerlagenteelt is een voorwaarde.

  19. 100 LPW 800 Lm Warm White LED

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Decai [Philips Lumileds Lighting Company, San Jose, CA (United States)

    2010-10-31

    An illumination grade warm white (WW) LED, having correlated color temperature (CCT) between 2800 K and 3500K and capable of producing 800 lm output at 100 lm/W, has been developed in this program. The high power WW LED is an ideal source for use as replacement for incandescent, and Halogen reflector and general purpose lamps of similar lumen value. Over the two year period, we have made following accomplishments: developed a high power warm white LED product and made over 50% improvements in light output and efficacy. The new high power WW LED product is a die on ceramic surface mountable LED package. It has four 1x1 mm{sup 2} InGaN pump dice flip chip attached to a ceramic submount in 2x2 array, covered by warm white phosphor ceramic platelets called Lumiramica and an overmolded silicone lens encapsulating the LED array. The performance goal was achieved through breakthroughs in following key areas: (1) High efficiency pump LED development through pump LED active region design and epi growth quality improvement (funded by internal programs). (2) Increase in injection efficiency (IE) represented by reduction in forward voltage (V{sub f}) through the improvement of the silver-based p-contact and a reduction in spreading resistance. The injection efficiency was increased from 80% at the start of the program to 96% at the end of the program at 700 mA/mm{sup 2}. (3) Improvement in thermal design as represented by reduction in thermal resistance from junction to case, through improvement of the die to submount connection in the thin film flip chip (TFFC) LED and choosing the submount material of high thermal conductivity. A thermal resistance of 1.72 K/W was demonstrated for the high power LED package. (4) Improvement in extraction efficiency from the LED package through improvement of InGaN die level and package level optical extraction efficiency improvement. (5) Improvement in phosphor system efficiency by improving the lumen equivalent (LE) and phosphor package

  20. High Performance Green LEDs by Homoepitaxial

    Energy Technology Data Exchange (ETDEWEB)

    Wetzel, Christian; Schubert, E Fred

    2009-11-22

    This work's objective was the development of processes to double or triple the light output power from green and deep green (525 - 555 nm) AlGaInN light emitting diode (LED) dies within 3 years in reference to the Lumileds Luxeon II. The project paid particular effort to all aspects of the internal generation efficiency of light. LEDs in this spectral region show the highest potential for significant performance boosts and enable the realization of phosphor-free white LEDs comprised by red-green-blue LED modules. Such modules will perform at and outperform the efficacy target projections for white-light LED systems in the Department of Energy's accelerated roadmap of the SSL initiative.

  1. White LEDs with limit luminous efficacy

    Energy Technology Data Exchange (ETDEWEB)

    Lisitsyn, V. M.; Stepanov, S. A., E-mail: stepanovsa@tpu.ru; Yangyang, Ju [National Research Tomsk Polytechnic University, 30 Lenin Av., Tomsk, 634050 (Russian Federation); Lukash, V. S. [JSC Research Institute of Semiconductor Devices, 99a Krasnoarmeyskaja St., Tomsk, 634050 (Russian Federation)

    2016-01-15

    In most promising widespread gallium nitride based LEDs emission is generated in the blue spectral region with a maximum at about 450 nm which is converted to visible light with the desired spectrum by means of phosphor. The thermal energy in the conversion is determined by the difference in the energies of excitation and emission quanta and the phosphor quantum yield. Heat losses manifest themselves as decrease in the luminous efficacy. LED heating significantly reduces its efficiency and life. In addition, while heating, the emission generation output and the efficiency of the emission conversion decrease. Therefore, the reduction of the energy losses caused by heating is crucial for LED development. In this paper, heat losses in phosphor-converted LEDs (hereinafter chips) during spectrum conversion are estimated. The limit values of the luminous efficacy for white LEDs are evaluated.

  2. An LED pulser for measuring photomultiplier linearity

    CERN Document Server

    Friend, M; Quinn, B

    2011-01-01

    A light-emitting diode (LED) pulser for testing the low-rate response of a photomultiplier tube (PMT) to scintillator-like pulses has been designed, developed, and implemented. This pulser is intended to simulate 80 ns full width at half maximum photon pulses over the dynamic range of the PMT, in order to precisely determine PMT linearity. This particular design has the advantage that, unlike many LED test rigs, it does not require the use of multiple calibrated LEDs, making it insensitive to LED gain drifts. Instead, a finite-difference measurement is made using two LEDs which need not be calibrated with respect to one another. These measurements give a better than 1% mapping of the response function, allowing for the testing and development of particularly linear PMT bases.

  3. An LED pulser for measuring photomultiplier linearity

    International Nuclear Information System (INIS)

    A light-emitting diode (LED) pulser for testing the low-rate response of a photomultiplier tube (PMT) to scintillator-like pulses has been designed, developed, and implemented. This pulser is intended to simulate 85 ns full width at half maximum photon pulses over the dynamic range of the PMT, in order to precisely determine PMT linearity. This particular design has the advantage that, unlike many LED test rigs, it does not require the use of multiple calibrated LEDs, making it insensitive to LED gain drifts. Instead, a finite-difference measurement is made using two LEDs which need not be calibrated with respect to one another. These measurements give a better than 1% mapping of the response function, allowing for the testing and development of particularly linear PMT bases. They also yield a functional form for the response of the PMT to a range of pulse sizes, which can be used in detector simulation.

  4. Using LEDs to reduce energy consumption

    Science.gov (United States)

    Eweni, Chukwuebuka E.

    The most popularly used light bulb in homes is the incandescent. It is also the least energy efficient. The filament in the bulb is so thin that it causes resistance in the electricity, which in turn causes the electricity's energy to form heat. This causes the incandescent to waste a lot of energy forming heat rather than forming the light. It uses 15 lumens per watt of input power. A recorded MATLAB demonstration showcased LED versatility and how it can be used by an Arduino UNO board. The objective of this thesis is to showcase how LEDs can reduce energy consumption through the use of an Arduino UNO board and MATLAB and to discuss the applications of LED. LED will be the future of lighting homes and will eventually completely incandescent bulbs when companies begin to make the necessary improvements to the LED.

  5. Dual drive; Doppelt angetrieben

    Energy Technology Data Exchange (ETDEWEB)

    Wilms, Jan

    2011-09-15

    The Opel Ampera was designed as an everyday car with an alternative drive system. A hybrid concept comprising both an electric motor and a gasoline engine ensures long mileage, but there is still the problem of high purchase cost.

  6. Safe driving for teens

    Science.gov (United States)

    ... for crashes. Drivers and passengers should use automobile safety features at all times. These include: seat belts, shoulder straps, and headrests. Only drive cars that have air bags, padded dashes, safety glass, ...

  7. Structural Flexibility of Large Direct Drive Generators for Wind Turbines

    OpenAIRE

    Shrestha, G.

    2013-01-01

    The trend in wind energy is towards large offshore wind farms. This trend has led to the demand for high reliability and large single unit wind turbines. Different energy conversion topologies such as multiple stage geared generators, single stage geared generators and gearless (direct drive) generators have been coupled to the wind turbine in the last decades. Direct drive generators based on permanent magnet technology have a high efficiency, less components and lower speeds that can transl...

  8. High performance drive circuits for integrated microLED/CMOS arrays for visible light communication (VLC)

    OpenAIRE

    Mahmood Zuhdi, Ahmad Wafi; Zuhdi, Ahmad

    2015-01-01

    Wireless communication is a form of communication that has been around for over hundreds of years and is the fastest growing segment of the communication industry. Today, wireless communication has become an essential part of almost everyone’s daily life, and the number of users has increased exponentially over the last decade with the introduction of the internet, mobile devices and smart phones. Radio Frequency (RF) transmission is arguably the most popular method of communic...

  9. Drunk Driving Campaign

    OpenAIRE

    Christoffersen, Mette Buhl; Vogel, Klara Elisa Pingel

    2014-01-01

    This project evaluates a communication product, consisting of three flush-ad posters against drunk driving. The target group of this campaign is young men in the ages 18-22 in the outskirts of Denmark. The project's scientific theoretical approach is phenomenology which will give insight in the target groups life situation, furthermore the social constructivist perspective is used to understand the target group's opinions in relation to product and subject drunk driving because of the interac...

  10. Drinking and driving

    OpenAIRE

    2003-01-01

    Alcohol misuse generates many health and social problems at a cost that society is increasingly unwilling to sustain. One of the most tragic consequences of alcohol misuse is the result of drinking and driving. Each week, impaired drivers kill 40 Canadian men, women and children and injure 1250 others. The Canadian Medical Association (CMA), in its campaign against drinking and driving, has recommended that a condition of obtaining or renewing a driver's licence include the individual's writt...

  11. Engineering Autonomous Driving Software

    OpenAIRE

    Berger, Christian; Rumpe, Bernhard

    2014-01-01

    A larger number of people with heterogeneous knowledge and skills running a project together needs an adaptable, target, and skill-specific engineering process. This especially holds for a project to develop a highly innovative, autonomously driving vehicle to participate in the 2007 DARPA Urban Challenge. In this contribution, we present essential elements of a software and systems engineering process to develop a so-called artificial intelligence capable of driving autonomously in complex u...

  12. Direct drive wind turbine

    Science.gov (United States)

    Bywaters, Garrett; Danforth, William; Bevington, Christopher; Stowell, Jesse; Costin, Daniel

    2006-07-11

    A wind turbine is provided that minimizes the size of the drive train and nacelle while maintaining the power electronics and transformer at the top of the tower. The turbine includes a direct drive generator having an integrated disk brake positioned radially inside the stator while minimizing the potential for contamination. The turbine further includes a means for mounting a transformer below the nacelle within the tower.

  13. Instant Google Drive starter

    CERN Document Server

    Procopio, Mike

    2013-01-01

    This book is a Starter which teaches you how to use Google Drive practically. This book is perfect for people of all skill levels who want to enjoy the benefits of using Google Drive to safely store their files online and in the cloud. It's also great for anyone looking to learn more about cloud computing in general. Readers are expected to have an Internet connection and basic knowledge of using the internet.

  14. Rumination in bipolar disorder: a systematic review

    Directory of Open Access Journals (Sweden)

    Érico de M. Silveira Jr.

    2015-09-01

    Full Text Available Objective:To conduct a systematic review of the literature about the symptom of rumination in bipolar disorder (BD.Methods:We searched the MEDLINE (PubMed, ISI Web of Knowledge, PsycINFO, and SciELO databases using the descriptors “rumination” and “bipolar disorder” and no time limits. This strategy yielded 105 references, of which 74 were selected. Inclusion criteria were studies involving patients with BD and the use of at least one validated scale for the assessment of rumination. Review articles were excluded. Seventeen articles were ultimately analyzed and included in the review.Results:Rumination is present in all BD phases, is a stable interepisodic symptom, is associated with symptoms of depression, anxiety, and hypomania, and may occur in response to both positive and negative affect. There is no research on rumination and neurobiological findings in patients with BD.Conclusions:Rumination seems to be independent of mood state, but shows close relationship with it. It is possible that rumination has a negative impact on cognitive and executive functions, particularly inhibitory control. Finally, rumination is an important symptom in both phases of BD, and, therefore, may be a useful target for further exploration as a dimensional domain and a transdiagnostic phenomenon in Research Domain Criteria (RDoC projects.

  15. Flyback Topology TEM Bipolar Pulse Transmitter

    Directory of Open Access Journals (Sweden)

    Guo-fu Wang

    2013-09-01

    Full Text Available In the fields of transient electromagnetic (TEM geophysical exploration, it is necessary to create a bipolar pulse current source with decline edge of high linearity, short turn-off time and high stability. In order to improve detection equipment’s practicality, it’s urgently needed to miniaturize and improve the reliability of the detection equipment. In this paper, a clamp and prompt drop bipolar pulse current circuit based on Flyback topology is represented, which can accelerate the decline of load current by clamping the coil load with fixed high voltage in the period of current declining. Also, because of this circuit’s low power consumption and significantly improvement of the transmitter’s energy utilization, chassis’s cooling equipment can be greatly reduced and it’s easier to miniaturize the transmitter. To start with, the principle of this circuit is represented. Then, the method is given to select the optimal values of circuit’s components. Finally, the results of simulation proves the proposed circuit meeting the requirements much better than those reported, with shorter turn-off time, higher linearity, less energy consumption. In general, this circuit has been successfully applied to a new type of detection equipment.

  16. Loopy: The Political Ontology of Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    RACHEL JANE LIEBERT

    2013-01-01

    Full Text Available This essay is at once a critical analysis, an experiment in form, and – with some irony – a cautionary tale. Triggered by the inclusion of prodromal diagnoses in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, and the recent call by the United States’ (U.S. Obama administration for increased mental health screening, I argue that shifts toward identifying and intervening on one’s potential madness, or risk, circulate with/in the contemporary U.S. climate of intensified discipline and terror, and use Bipolar Disorder as a site to critically explore how and with what implications this circulation occurs. Specifically, I weave Massumi’s ‘political ontology of threat’ with the narrative of a woman diagnosed with Bipolar Disorder in order to trace the pre-emptive politics and affective logic of a risk-based approach to madness. I contend that the diagnosing and drugging of potential is a self-perpetuating loop that is personally and politically harmful, and consider alternatives to this burgeoning practice.

  17. The efficacy of Li in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Lozano R

    2013-07-01

    Full Text Available R Lozano,1 R Marín,2 MJ Santacruz,2 I Freire,2 R Gomez21Department of Pharmacy, 2Department of Psychiatry, Hospital Real Nuestra Señora de Gracia, Zaragoza, SpainThe efficacy of lithium (Li for acute mania and as prophylaxis against recurrent episodes of mania in bipolar disorder has been well established, with the minimum effective Li serum concentration for acute mania in the range of 0.6–1.2 mEq/L, although lower maintenance concentrations can prove effective in some patients.1–5Thyroid disorders are also associated with alterations in mood, and patients with hypothyroidism may present with depression and cognitive dysfunction,6–8 while patients with hyperthyroidism may present with anxiety, depression, mood lability,7,9 and manic symptoms.10 However, considering that overt hyperthyroidism is uncommon in bipolar disorder, with a prevalence ≤2% across different studies,11,12 this has been largely attributed to lithium,13 with rates varying from 0 to 47% (average of about 10% among patients on long-term treatment with lithium.13–16

  18. A linkage study of bipolar disorder

    Energy Technology Data Exchange (ETDEWEB)

    Kelsoe, J.R. [Univ. of California, San Diego (United States); Sadovnick, A.D.; Remick, R.A. [Univ. of British Columbia, Vancouver (Canada)] [and others

    1994-09-01

    We are currently surveying the genome with polymorphic DNA markers in search of loci linked to bipolar disorder (manic-depressive illness) in three populations: 20 families (175 subjects) from the general North American population from San Diego (UCSD) and Vancouver (UBC); 3 Icelandic families (55 subjects); and an Old Order Amish pedigree 110 (118 subjects). Over 50 markers on chromosomes 1, 2, 5, 11, 17, 18, 20 and 21 have been examined. All markers have been tested in the Amish and Icelandic families, and a portion of them in the UCSD/UBC families, which we have only recently begun genotyping. The following candidate genes have been examined: {beta}-TSH, dopamine transporter (HDAT), {beta}2 adrenergic receptor (ADRB2), glucocorticoid type II receptor (GRL), D2 dopamine receptor, serotonin transporter (HSERT), and G{alpha}s G protein subunit (GNAS1). Linkage analysis was conducted using an autosomal dominant model with age-dependent reduced penetrance. Subjects with bipolar, schizoaffective, or recurrent major depressive disorders were considered affected. No significant evidence for linkage was obtained. Mildly positive lods ranging between 1.1 and 1.6 were obtained for three loci: D11S29, HDAT, and GRL.

  19. The last deglaciation: timing the bipolar seesaw

    Directory of Open Access Journals (Sweden)

    J. B. Pedro

    2011-01-01

    Full Text Available Precise information on the relative timing of north-south climate variations is a key to resolving questions concerning the mechanisms that force and couple climate changes between the hemispheres. We present a new composite record made from five well-resolved Antarctic ice core records that robustly represents the timing of regional Antarctic climate change during the last deglaciation. Using fast variations in global methane gas concentrations as time markers, the Antarctic composite is directly compared to Greenland ice core records, allowing a detailed mapping of the inter-hemispheric sequence of climate changes. Consistent with prior studies the synchronized records show that warming (and cooling trends in Antarctica closely match cold (and warm periods in Greenland on millennial timescales. For the first time, we also identify a sub-millennial component to the inter-hemispheric coupling: within the Antarctic Cold Reversal the strongest Antarctic cooling occurs during the pronounced northern warmth of the Bølling; warming then resumes in Antarctica during the Intra-Allerød Cold Period i.e. prior to the Younger Dryas stadial. There is little-to-no time lag between climate transitions in Greenland and opposing changes in Antarctica. Our results lend support to fast acting inter-hemispheric coupling mechanisms including recently proposed bipolar atmospheric teleconnections and/or rapid bipolar ocean teleconnections.

  20. The last deglaciation: timing the bipolar seesaw

    Directory of Open Access Journals (Sweden)

    J. B. Pedro

    2011-06-01

    Full Text Available Precise information on the relative timing of north-south climate variations is a key to resolving questions concerning the mechanisms that force and couple climate changes between the hemispheres. We present a new composite record made from five well-resolved Antarctic ice core records that robustly represents the timing of regional Antarctic climate change during the last deglaciation. Using fast variations in global methane gas concentrations as time markers, the Antarctic composite is directly compared to Greenland ice core records, allowing a detailed mapping of the inter-hemispheric sequence of climate changes. Consistent with prior studies the synchronized records show that warming (and cooling trends in Antarctica closely match cold (and warm periods in Greenland on millennial timescales. For the first time, we also identify a sub-millennial component to the inter-hemispheric coupling. Within the Antarctic Cold Reversal the strongest Antarctic cooling occurs during the pronounced northern warmth of the Bølling. Warming then resumes in Antarctica, potentially as early as the Intra-Allerød Cold Period, but with dating uncertainty that could place it as late as the onset of the Younger Dryas stadial. There is little-to-no time lag between climate transitions in Greenland and opposing changes in Antarctica. Our results lend support to fast acting inter-hemispheric coupling mechanisms, including recently proposed bipolar atmospheric teleconnections and/or rapid bipolar ocean teleconnections.