WorldWideScience

Sample records for bipolar field structures

  1. Electric field with bipolar structure during magnetic reconnection without a guide field

    Science.gov (United States)

    Guo, Jun

    2014-05-01

    We present a study on the polarized electric field during the collisionless magnetic reconnection of antiparallel fields using two dimensional particle-in-cell simulations. The simulations demonstrate clearly that electron holes and electric field with bipolar structure are produced during magnetic reconnection without a guide field. The electric field with bipolar structure can be found near the X-line and on the separatrix and the plasma sheet boundary layer, which is consistent with the observations. These structures will elongate electron's time staying in the diffusion region. In addition, the electric fields with tripolar structures are also found in our simulation.

  2. Neutrality in bipolar structures

    DEFF Research Database (Denmark)

    Montero, Javier; Rodríguez, J. Tinguaro; Franco, Camilo

    2014-01-01

    In this paper, we want to stress that bipolar knowledge representation naturally allows a family of middle states which define as a consequence different kinds of bipolar structures. These bipolar structures are deeply related to the three types of bipolarity introduced by Dubois and Prade, but our...... approach offers a systematic explanation of how such bipolar structures appear and can be identified....

  3. Paired structures and bipolar knowledge representation

    DEFF Research Database (Denmark)

    Montero, Javier; Bustince, Humberto; Franco, Camilo

    In this strictly positional paper we propose a general approach to bipolar knowledge representation, where the meaning of concepts can be modelled by examining their decomposition into opposite and neutral categories. In particular, it is the semantic relationship between the opposite categories...... and at the same time the type of neutrality rising in between opposites. Based on this first level of bipolar knowledge representation, paired structures in fact offer the means to characterize a specific bipolar valuation scale depending on the meaning of the concept that has to be verified. In this sense...

  4. Application of Bipolar Fuzzy Sets in Graph Structures

    Directory of Open Access Journals (Sweden)

    Muhammad Akram

    2016-01-01

    Full Text Available A graph structure is a useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we apply the concept of bipolar fuzzy sets to graph structures. We introduce certain notions, including bipolar fuzzy graph structure (BFGS, strong bipolar fuzzy graph structure, bipolar fuzzy Ni-cycle, bipolar fuzzy Ni-tree, bipolar fuzzy Ni-cut vertex, and bipolar fuzzy Ni-bridge, and illustrate these notions by several examples. We study ϕ-complement, self-complement, strong self-complement, and totally strong self-complement in bipolar fuzzy graph structures, and we investigate some of their interesting properties.

  5. Coronal rain in magnetic bipolar weak fields

    Science.gov (United States)

    Xia, C.; Keppens, R.; Fang, X.

    2017-07-01

    Aims: We intend to investigate the underlying physics for the coronal rain phenomenon in a representative bipolar magnetic field, including the formation and the dynamics of coronal rain blobs. Methods: With the MPI-AMRVAC code, we performed three dimensional radiative magnetohydrodynamic (MHD) simulation with strong heating localized on footpoints of magnetic loops after a relaxation to quiet solar atmosphere. Results: Progressive cooling and in-situ condensation starts at the loop top due to radiative thermal instability. The first large-scale condensation on the loop top suffers Rayleigh-Taylor instability and becomes fragmented into smaller blobs. The blobs fall vertically dragging magnetic loops until they reach low-β regions and start to fall along the loops from loop top to loop footpoints. A statistic study of the coronal rain blobs finds that small blobs with masses of less than 1010 g dominate the population. When blobs fall to lower regions along the magnetic loops, they are stretched and develop a non-uniform velocity pattern with an anti-parallel shearing pattern seen to develop along the central axis of the blobs. Synthetic images of simulated coronal rain with Solar Dynamics Observatory Atmospheric Imaging Assembly well resemble real observations presenting dark falling clumps in hot channels and bright rain blobs in a cool channel. We also find density inhomogeneities during a coronal rain "shower", which reflects the observed multi-stranded nature of coronal rain. Movies associated to Figs. 3 and 7 are available at http://www.aanda.org

  6. Theory of Weak Bipolar Fields and Electron Holes with Applications to Space Plasmas

    International Nuclear Information System (INIS)

    Goldman, Martin V.; Newman, David L.; Mangeney, Andre

    2007-01-01

    A theoretical model of weak electron phase-space holes is used to interpret bipolar field structures observed in space. In the limit eφ max /T e max sech 4 (x/α), where φ max depends on the derivative of the trapped distribution at the separatrix, while α depends only on a screening integral over the untrapped distribution. Idealized trapped and passing electron distributions are inferred from the speed, amplitude, and shape of satellite waveform measurements of weak bipolar field structures

  7. Vector optical fields with bipolar symmetry of linear polarization.

    Science.gov (United States)

    Pan, Yue; Li, Yongnan; Li, Si-Min; Ren, Zhi-Cheng; Si, Yu; Tu, Chenghou; Wang, Hui-Tian

    2013-09-15

    We focus on a new kind of vector optical field with bipolar symmetry of linear polarization instead of cylindrical and elliptical symmetries, enriching members of family of vector optical fields. We design theoretically and generate experimentally the demanded vector optical fields and then explore some novel tightly focusing properties. The geometric configurations of states of polarization provide additional degrees of freedom assisting in engineering the field distribution at the focus to the specific applications such as lithography, optical trapping, and material processing.

  8. Optimization Design of Bipolar Plate Flow Field in PEM Stack

    Science.gov (United States)

    Wen, Ming; He, Kanghao; Li, Peilong; Yang, Lei; Deng, Li; Jiang, Fei; Yao, Yong

    2017-12-01

    A new design of bipolar plate flow field in proton exchange membrane (PEM) stack was presented to develop a high-performance transfer efficiency of the two-phase flow. Two different flow fields were studied by using numerical simulations and the performance of the flow fields was presented. the hydrodynamic properties include pressure gap between inlet and outlet, the Reynold’s number of the two types were compared based on the Navier-Stokes equations. Computer aided optimization software was implemented in the design of experiments of the preferable flow field. The design of experiments (DOE) for the favorable concept was carried out to study the hydrodynamic properties when changing the design parameters of the bipolar plate.

  9. Spectrum and the structure of the bipolar nebula S 106

    Energy Technology Data Exchange (ETDEWEB)

    Solf, J [Max-Planck-Institut fuer Astronomie, Heidelberg (Germany, F.R.)

    1980-12-01

    Optically the compact region S 106 appears as a bipolar nebula with the exciting stellar source located between the lobes and embedded in a flat disk of material of high visual extinction. Associated with the nebula is a massive molecular cloud exhibiting a rotating disk-like structure, the axis of rotation being observed in the same direction as the bipolar axis of the nebula. We analyse new optical and near-infrared spectra obtained with an image-tube spectrograph. The emission line spectrum of both lobes resembles that of the Orion nebula and indicates high electron density throughout. The nebular continuum discovered in both lobes is interpreted as originating from an early-type stellar source between the lobes, and scattered by dust particles coexisting with the ionized gas within the lobes. The Hsub(..cap alpha..) radial velocity field indicates supersonic motion of ionized material flowing radially outward through the lobes. The shape and kinematic structure of the lobes are in qualitative agreement with the predictions of the champagne model of Tenorio-Tagle (1979) applied to the case of star formation near the center of a disk-shaped dense cloud.

  10. Adaptive finite-element ballooning analysis of bipolar ionized fields

    International Nuclear Information System (INIS)

    Al-Hamouz, Z.M.

    1995-01-01

    This paper presents an adaptive finite-element iterative method for the analysis of the ionized field around high-voltage bipolar direct-current (HVDC) transmission line conductors without resort to Deutsch's assumption. A new iterative finite-element ballooning technique is proposed to solve Poisson's equation wherein the commonly used artificial boundary around the transmission line conductors is simulated at infinity. Unlike all attempts reported in the literature for the solution of ionized field, the constancy of the conductors' surface field at the corona onset value is directly implemented in the finite-element formulation. In order to investigate the effectiveness of the proposed method, a laboratory model was built. It has been found that the calculated V-I characteristics and the ground-plane current density agreed well with those measured experimentally. The simplicity in computer programming in addition to the low number of iterations required to achieve convergence characterize this method of analysis

  11. Models for the structure and origin of bipolar nebulae

    International Nuclear Information System (INIS)

    Morris, M.

    1981-01-01

    The appearance of bipolar nebulae-symmetric reflection nebulae centered on evolved, mass-losing stars-can most simply be accounted for in terms of an axisymmetric distribution of outflowing dust in which the dust is concentrated towards an equatorial plane and declines monotonically with latitude above that plane. The symmetrically placed ''horns'' that can be seen radiating out of some bipolar nebulae, notably GL 2688, are a natural consequence of such a dust distribution if, at some latitude, the radial optical depth to starlight falls rapidly below unity. Several models of bipolar nebulae are presented. These structural models for bipolar nebulae lead in turn to an investigation of how such a geometry might arise. Although nonradial pulsation, rotationally forced mass ejection by a single star, and mass loss from a common envelope binary are all considered, the most attractive origin for bipolar nebulae is a binary star system in which the primary is evolving up the red giant branch to the point at which its radius approaches its tidal radius. If this occurs before corotation of the primary with the secondary's orbit can be achieved, then matter from the primary's enveloped can be gravitationally ejected from the system by the secondary, the ejected material being concentrated toward the system's equatorial plane. Numerical models of this phenomenon show that gravitational ejection from an asynchronous binary system easily leads to terminal outflow velocities in the observed range (20--50 km s -1 ), and that the rate of mass loss and the time scale over which the mass ejection takes place are consistent with observations if the particle density in the outer layers of the primary's atmosphere from which the material is extracted is in the range 10 14 --10 15 cm -3 . If this hypothesis is applicable, bipolar nebulae will probably become planetary nebulae, as previously suggested on observational grounds

  12. Particle Agglomeration in Bipolar Barb Agglomerator Under AC Electric Field

    International Nuclear Information System (INIS)

    Huang Chao; Ma Xiuqin; Sun Youshan; Wang Meiyan; Zhang Changping; Lou Yueya

    2015-01-01

    The development of an efficient technology for removing fine particles in flue gas is essential as the haze is becoming more and more serious. To improve agglomeration effectiveness of fine particles, a dual zone electric agglomeration device consisting of a charging chamber and an agglomeration chamber with bipolar barb electrodes was developed. The bipolar barb electric agglomerator with a polar distance of 200 mm demonstrates good agglomeration effectiveness for particles with a size less than 8.0 μm under applied AC electric field. An optimal condition for achieving better agglomeration effectiveness was found to be as follows: flue gas flow velocity of 3.00 m/s, particle concentration of 2.00 g/m 3 , output voltage of 35 kV and length of the barb of 16 mm. In addition, 4.0–6.0 μm particles have the best effectiveness with the variation of particle volume occupancy of −3.2. (paper)

  13. Particle Agglomeration in Bipolar Barb Agglomerator Under AC Electric Field

    Science.gov (United States)

    Huang, Chao; Ma, Xiuqin; Sun, Youshan; Wang, Meiyan; Zhang, Changping; Lou, Yueya

    2015-04-01

    The development of an efficient technology for removing fine particles in flue gas is essential as the haze is becoming more and more serious. To improve agglomeration effectiveness of fine particles, a dual zone electric agglomeration device consisting of a charging chamber and an agglomeration chamber with bipolar barb electrodes was developed. The bipolar barb electric agglomerator with a polar distance of 200 mm demonstrates good agglomeration effectiveness for particles with a size less than 8.0 μm under applied AC electric field. An optimal condition for achieving better agglomeration effectiveness was found to be as follows: flue gas flow velocity of 3.00 m/s, particle concentration of 2.00 g/m3, output voltage of 35 kV and length of the barb of 16 mm. In addition, 4.0-6.0 μm particles have the best effectiveness with the variation of particle volume occupancy of -3.2. supported by the Key Technology R&D Program of Hebei, China (No. 13211207D)

  14. Brain Structural Effects of Psychopharmacological Treatment in Bipolar Disorder

    Science.gov (United States)

    McDonald, Colm

    2015-01-01

    Bipolar disorder is associated with subtle neuroanatomical deficits including lateral ventricular enlargement, grey matter deficits incorporating limbic system structures, and distributed white matter pathophysiology. Substantial heterogeneity has been identified by structural neuroimaging studies to date and differential psychotropic medication use is potentially a substantial contributor to this. This selective review of structural neuroimaging and diffusion tensor imaging studies considers evidence that lithium, mood stabilisers, antipsychotic medication and antidepressant medications are associated with neuroanatomical variation. Most studies are negative and suffer from methodological weaknesses in terms of directly assessing medication effects on neuroanatomy, since they commonly comprise posthoc assessments of medication associations with neuroimaging metrics in small heterogenous patient groups. However the studies which report positive findings tend to form a relatively consistent picture whereby lithium and antiepileptic mood stabiliser use is associated with increased regional grey matter volume, especially in limbic structures. These findings are further supported by the more methodologically robust studies which include large numbers of patients or repeated intra-individual scanning in longitudinal designs. Some similar findings of an apparently ameliorative effect of lithium on white matter microstructure are also emerging. There is less support for an effect of antipsychotic or antidepressant medication on brain structure in bipolar disorder, but these studies are further limited by methodological difficulties. In general the literature to date supports a normalising effect of lithium and mood stabilisers on brain structure in bipolar disorder, which is consistent with the neuroprotective characteristics of these medications identified by preclinical studies. PMID:26412064

  15. Tripolar electric field Structure in guide field magnetic reconnection

    Science.gov (United States)

    Fu, Song; Huang, Shiyong; Zhou, Meng; Ni, Binbin; Deng, Xiaohua

    2018-03-01

    It has been shown that the guide field substantially modifies the structure of the reconnection layer. For instance, the Hall magnetic and electric fields are distorted in guide field reconnection compared to reconnection without guide fields (i.e., anti-parallel reconnection). In this paper, we performed 2.5-D electromagnetic full particle simulation to study the electric field structures in magnetic reconnection under different initial guide fields (Bg). Once the amplitude of a guide field exceeds 0.3 times the asymptotic magnetic field B0, the traditional bipolar Hall electric field is clearly replaced by a tripolar electric field, which consists of a newly emerged electric field and the bipolar Hall electric field. The newly emerged electric field is a convective electric field about one ion inertial length away from the neutral sheet. It arises from the disappearance of the Hall electric field due to the substantial modification of the magnetic field and electric current by the imposed guide field. The peak magnitude of this new electric field increases linearly with the increment of guide field strength. Possible applications of these results to space observations are also discussed.

  16. Tripolar electric field Structure in guide field magnetic reconnection

    Directory of Open Access Journals (Sweden)

    S. Fu

    2018-03-01

    Full Text Available It has been shown that the guide field substantially modifies the structure of the reconnection layer. For instance, the Hall magnetic and electric fields are distorted in guide field reconnection compared to reconnection without guide fields (i.e., anti-parallel reconnection. In this paper, we performed 2.5-D electromagnetic full particle simulation to study the electric field structures in magnetic reconnection under different initial guide fields (Bg. Once the amplitude of a guide field exceeds 0.3 times the asymptotic magnetic field B0, the traditional bipolar Hall electric field is clearly replaced by a tripolar electric field, which consists of a newly emerged electric field and the bipolar Hall electric field. The newly emerged electric field is a convective electric field about one ion inertial length away from the neutral sheet. It arises from the disappearance of the Hall electric field due to the substantial modification of the magnetic field and electric current by the imposed guide field. The peak magnitude of this new electric field increases linearly with the increment of guide field strength. Possible applications of these results to space observations are also discussed.

  17. Brain structure and the relationship with neurocognitive functioning in schizophrenia and bipolar disorder : MRI studies

    OpenAIRE

    Hartberg, Cecilie Bhandari

    2011-01-01

    Brain structural abnormalities as well as neurocognitive dysfunction, are found in schizophrenia and in bipolar disorder. Based on the fact that both brain structure and neurocognitive functioning are significantly heritable and affected in both schizophrenia and bipolar disorder, relationships between them are expected. However, previous studies report inconsistent findings. Also, schizophrenia and bipolar disorder are classified as separate disease entities, but demonstrate overlap with reg...

  18. Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder.

    Science.gov (United States)

    Hare, Elizabeth; Contreras, Javier; Raventos, Henriette; Flores, Deborah; Jerez, Alvaro; Nicolini, Humberto; Ontiveros, Alfonso; Almasy, Laura; Escamilla, Michael

    2012-02-01

    Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (-0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (-0.35), conscientiousness (-0.39), and extraversion (-0.44). A positive correlation (0.37) was found with neuroticism. It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on

  19. Charge Yield at Low Electric Fields: Considerations for Bipolar Integrated Circuits

    Science.gov (United States)

    Johnston, A. H.; Swimm, R. T.; Thorbourn, D. O.

    2013-01-01

    A significant reduction in total dose damage is observed when bipolar integrated circuits are irradiated at low temperature. This can be partially explained by the Onsager theory of recombination, which predicts a strong temperature dependence for charge yield under low-field conditions. Reduced damage occurs for biased as well as unbiased devices because the weak fringing field in thick bipolar oxides only affects charge yield near the Si/SiO2 interface, a relatively small fraction of the total oxide thickness. Lowering the temperature of bipolar ICs - either continuously, or for time periods when they are exposed to high radiation levels - provides an additional degree of freedom to improve total dose performance of bipolar circuits, particularly in space applications.

  20. Highly conductive composites for fuel cell flow field plates and bipolar plates

    Science.gov (United States)

    Jang, Bor Z; Zhamu, Aruna; Song, Lulu

    2014-10-21

    This invention provides a fuel cell flow field plate or bipolar plate having flow channels on faces of the plate, comprising an electrically conductive polymer composite. The composite is composed of (A) at least 50% by weight of a conductive filler, comprising at least 5% by weight reinforcement fibers, expanded graphite platelets, graphitic nano-fibers, and/or carbon nano-tubes; (B) polymer matrix material at 1 to 49.9% by weight; and (C) a polymer binder at 0.1 to 10% by weight; wherein the sum of the conductive filler weight %, polymer matrix weight % and polymer binder weight % equals 100% and the bulk electrical conductivity of the flow field or bipolar plate is at least 100 S/cm. The invention also provides a continuous process for cost-effective mass production of the conductive composite-based flow field or bipolar plate.

  1. Bipolar Jets Launched by a Mean-field Accretion Disk Dynamo

    Science.gov (United States)

    Fendt, Christian; Gaßmann, Dennis

    2018-03-01

    By applying magnetohydrodynamic simulations, we investigate the launching of jets driven by a disk magnetic field generated by a mean-field disk dynamo. Extending our earlier studies, we explore the bipolar evolution of the disk α 2Ω-dynamo and the outflow. We confirm that a negative dynamo-α leads to a dipolar field geometry, whereas positive values generate quadrupolar fields. The latter remain mainly confined to the disk and cannot launch outflows. We investigate a parameter range for the dynamo-α ranging from a critical value below which field generation is negligible, {α }0,{crit}=-0.0005, to α 0 = ‑1.0. For weak | {α }0| ≤slant 0.07, two magnetic loop structures with opposite polarity may arise, which leads to reconnection and disturbs the field evolution and accretion-ejection process. For a strong dynamo-α, a higher poloidal magnetic energy is reached, roughly scaling with {E}mag}∼ | {α }0| , which also leads to higher accretion and ejection rates. The terminal jet speed is governed by the available magnetic energy and increases with the dynamo-α. We find jet velocities on the order of the inner disk Keplerian velocity. For a strong dynamo-α, oscillating dynamo modes may occur that can lead to a pulsed ejection. This is triggered by an oscillating mode in the toroidal field component. The oscillation period is comparable to the Keplerian timescale in the launching region, thus too short to be associated with the knots in observed jets. We find a hemispherically asymmetric evolution for the jet and counter-jet in the mass flux and field structure.

  2. Brain structure in schizophrenia vs. psychotic bipolar I disorder: A VBM study.

    Science.gov (United States)

    Nenadic, Igor; Maitra, Raka; Langbein, Kerstin; Dietzek, Maren; Lorenz, Carsten; Smesny, Stefan; Reichenbach, Jürgen R; Sauer, Heinrich; Gaser, Christian

    2015-07-01

    While schizophrenia and bipolar disorder have been assumed to share phenotypic and genotypic features, there is also evidence for overlapping brain structural correlates, although it is unclear whether these relate to shared psychotic features. In this study, we used voxel-based morphometry (VBM8) in 34 schizophrenia patients, 17 euthymic bipolar I disorder patients (with a history of psychotic symptoms), and 34 healthy controls. Our results indicate that compared to healthy controls schizophrenia patients show grey matter deficits (pright dorsolateral prefrontal, as well as bilaterally in ventrolateral prefrontal and insular cortical areas, thalamus (bilaterally), left superior temporal cortex, and minor medial parietal and parietooccipital areas. Comparing schizophrenia vs. bipolar I patients (pleft dorsolateral prefrontal cortex, and left cerebellum. Compared to healthy controls, the deficits in bipolar I patients only reached significance at prights reserved.

  3. Flow field bipolar plates in a proton exchange membrane fuel cell: Analysis & modeling

    International Nuclear Information System (INIS)

    Kahraman, Huseyin; Orhan, Mehmet F.

    2017-01-01

    Highlights: • Covers a comprehensive review of available flow field channel configurations. • Examines the main design considerations and limitations for a flow field network. • Explores the common materials and material properties used for flow field plates. • Presents a case study of step-by-step modeling for an optimum flow field design. - Abstract: This study investigates flow fields and flow field plates (bipolar plates) in proton exchange membrane fuel cells. In this regard, the main design considerations and limitations for a flow field network have been examined, along with a comprehensive review of currently available flow field channel configurations. Also, the common materials and material properties used for flow field plates have been explored. Furthermore, a case study of step-by-step modeling for an optimum flow field design has been presented in-details. Finally, a parametric study has been conducted with respect to many design and performance parameters in a flow field plate.

  4. Factor analysis of regional brain activation in bipolar and healthy individuals reveals a consistent modular structure.

    Science.gov (United States)

    Fleck, David E; Welge, Jeffrey A; Eliassen, James C; Adler, Caleb M; DelBello, Melissa P; Strakowski, Stephen M

    2018-07-01

    The neurophysiological substrates of cognition and emotion, as seen with fMRI, are generally explained using modular structures. The present study was designed to probe the modular structure of cognitive-emotional processing in bipolar and healthy individuals using factor analysis and compare the results with current conceptions of the neurophysiology of bipolar disorder. Exploratory factor analysis was used to assess patterns of covariation among brain regions-of-interest activated during the Continuous Performance Task with Emotional and Neutral Distractors in healthy and bipolar individuals without a priori constraints on the number or composition of latent factors. Results indicated a common cognitive-emotional network consisting of prefrontal, medial temporal, limbic, parietal, anterior cingulate and posterior cingulate modules. However, reduced brain activation to emotional stimuli in the frontal, medial temporal and limbic modules was apparent in the bipolar relative to the healthy group, potentially accounting for emotional dysregulation in bipolar disorder. This study is limited by a relatively small sample size recruited at a single site. The results have yet to be validated on a larger independent sample. Although the modular structure of cognitive-emotional processing is similar in bipolar and healthy individuals, activation in response to emotional/neutral cues varies. These findings are not only consistent with recent conceptions of mood regulation in bipolar disorder, but also suggest that regional activation can be considered within tighter modular structures without compromising data interpretation. This demonstration may serve as a template for data reduction in future region-of-interest analyses to increase statistical power. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Structural brain network analysis in families multiply affected with bipolar I disorder

    NARCIS (Netherlands)

    Forde, Natalie J.; O'Donoghue, Stefani; Scanlon, Cathy; Emsell, Louise; Chaddock, Chris; Leemans, Alexander; Jeurissen, Ben; Barker, Gareth J.; Cannon, Dara M.; Murray, Robin M.; McDonald, Colm

    2015-01-01

    Disrupted structural connectivity is associated with psychiatric illnesses including bipolar disorder (BP). Here we use structural brain network analysis to investigate connectivity abnormalities in multiply affected BP type I families, to assess the utility of dysconnectivity as a biomarker and its

  6. Abnormal white matter integrity as a structural endophenotype for bipolar disorder.

    Science.gov (United States)

    Sarıçiçek, A; Zorlu, N; Yalın, N; Hıdıroğlu, C; Çavuşoğlu, B; Ceylan, D; Ada, E; Tunca, Z; Özerdem, A

    2016-05-01

    Several lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls. A total of 27 euthymic patients with BD type I, 20 unaffected siblings of bipolar patients and 29 healthy controls who did not have any current or past diagnosis of Axis I psychiatric disorders were enrolled in the study. Fractional anisotropy (FA) was significantly lower in BD patients than in the control group in the corpus callosum, fornix, bilateral superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, posterior thalamic radiation, cingulum, uncinate fasciculus, superior corona radiata, anterior corona radiata and left external capsule. In region-of-interest (ROI) analyses, we found that both unaffected siblings and bipolar patients had significantly reduced FA in the left posterior thalamic radiation, the left sagittal stratum, and the fornix compared with healthy controls. Average FA for unaffected siblings was intermediate between the healthy controls and bipolar patients within these ROIs. Decreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.

  7. Brain structural changes in schizoaffective disorder compared to schizophrenia and bipolar disorder.

    Science.gov (United States)

    Amann, B L; Canales-Rodríguez, E J; Madre, M; Radua, J; Monte, G; Alonso-Lana, S; Landin-Romero, R; Moreno-Alcázar, A; Bonnin, C M; Sarró, S; Ortiz-Gil, J; Gomar, J J; Moro, N; Fernandez-Corcuera, P; Goikolea, J M; Blanch, J; Salvador, R; Vieta, E; McKenna, P J; Pomarol-Clotet, E

    2016-01-01

    Brain structural changes in schizoaffective disorder, and how far they resemble those seen in schizophrenia and bipolar disorder, have only been studied to a limited extent. Forty-five patients meeting DSM-IV and RDC criteria for schizoaffective disorder, groups of patients with 45 matched schizophrenia and bipolar disorder, and 45 matched healthy controls were examined using voxel-based morphometry (VBM). Analyses comparing each patient group with the healthy control subjects found that the patients with schizoaffective disorder and the patients with schizophrenia showed widespread and overlapping areas of significant volume reduction, but the patients with bipolar disorder did not. A subsequent analysis compared the combined group of patients with the controls followed by extraction of clusters. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. The findings provide evidence that, in terms of structural gray matter brain abnormality, schizoaffective disorder resembles schizophrenia more than bipolar disorder. © 2015 The Authors. Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd.

  8. The validity and internal structure of the Bipolar Depression Rating Scale: data from a clinical trial of N-acetylcysteine as adjunctive therapy in bipolar disorder.

    Science.gov (United States)

    Berk, Michael; Dodd, Seetal; Dean, Olivia M; Kohlmann, Kristy; Berk, Lesley; Malhi, Gin S

    2010-10-01

    Berk M, Dodd S, Dean OM, Kohlmann K, Berk L, Malhi GS. The validity and internal structure of the Bipolar Depression Rating Scale: data from a clinical trial of N-acetylcysteine as adjunctive therapy in bipolar disorder. The phenomenology of unipolar and bipolar disorders differ in a number of ways, such as the presence of mixed states and atypical features. Conventional depression rating instruments are designed to capture the characteristics of unipolar depression and have limitations in capturing the breadth of bipolar disorder. The Bipolar Depression Rating Scale (BDRS) was administered together with the Montgomery Asberg Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) in a double-blind randomised placebo-controlled clinical trial of N-acetyl cysteine for bipolar disorder (N = 75). A factor analysis showed a two-factor solution: depression and mixed symptom clusters. The BDRS has strong internal consistency (Cronbach's alpha = 0.917), the depression cluster showed robust correlation with the MADRS (r = 0.865) and the mixed subscale correlated with the YMRS (r = 0.750). The BDRS has good internal validity and inter-rater reliability and is sensitive to change in the context of a clinical trial.

  9. Personality in proportion : A bipolar proportional scale for personality assessments and its consequences for trait structure

    NARCIS (Netherlands)

    Hofstee, W.K.B.; Ten Berge, J.M.F.

    2004-01-01

    Trait structures resulting from personality assessments on Likert scales are affected by the additive and multiplicative transformations implied in interval scaling and correlational analysis. The effect comes into view on selecting a plausible alternative scale. To this end, we propose a bipolar

  10. Brain structure-function associations in multi-generational families genetically enriched for bipolar disorder.

    Science.gov (United States)

    Fears, Scott C; Schür, Remmelt; Sjouwerman, Rachel; Service, Susan K; Araya, Carmen; Araya, Xinia; Bejarano, Julio; Knowles, Emma; Gomez-Makhinson, Juliana; Lopez, Maria C; Aldana, Ileana; Teshiba, Terri M; Abaryan, Zvart; Al-Sharif, Noor B; Navarro, Linda; Tishler, Todd A; Altshuler, Lori; Bartzokis, George; Escobar, Javier I; Glahn, David C; Thompson, Paul M; Lopez-Jaramillo, Carlos; Macaya, Gabriel; Molina, Julio; Reus, Victor I; Sabatti, Chiara; Cantor, Rita M; Freimer, Nelson B; Bearden, Carrie E

    2015-07-01

    Recent theories regarding the pathophysiology of bipolar disorder suggest contributions of both neurodevelopmental and neurodegenerative processes. While structural neuroimaging studies indicate disease-associated neuroanatomical alterations, the behavioural correlates of these alterations have not been well characterized. Here, we investigated multi-generational families genetically enriched for bipolar disorder to: (i) characterize neurobehavioural correlates of neuroanatomical measures implicated in the pathophysiology of bipolar disorder; (ii) identify brain-behaviour associations that differ between diagnostic groups; (iii) identify neurocognitive traits that show evidence of accelerated ageing specifically in subjects with bipolar disorder; and (iv) identify brain-behaviour correlations that differ across the age span. Structural neuroimages and multi-dimensional assessments of temperament and neurocognition were acquired from 527 (153 bipolar disorder and 374 non-bipolar disorder) adults aged 18-87 years in 26 families with heavy genetic loading for bipolar disorder. We used linear regression models to identify significant brain-behaviour associations and test whether brain-behaviour relationships differed: (i) between diagnostic groups; and (ii) as a function of age. We found that total cortical and ventricular volume had the greatest number of significant behavioural associations, and included correlations with measures from multiple cognitive domains, particularly declarative and working memory and executive function. Cortical thickness measures, in contrast, showed more specific associations with declarative memory, letter fluency and processing speed tasks. While the majority of brain-behaviour relationships were similar across diagnostic groups, increased cortical thickness in ventrolateral prefrontal and parietal cortical regions was associated with better declarative memory only in bipolar disorder subjects, and not in non-bipolar disorder family

  11. Radiation effects on junction field-effect transistors (JFETS), MOSFETs, and bipolar transistors, as related to SSC circuit design

    International Nuclear Information System (INIS)

    Kennedy, E.J.; Alley, G.T.; Britton, C.L. Jr.; Skubic, P.L.; Gray, B.; Wu, A.

    1990-01-01

    Some results of radiation effects on selected junction field-effect transistors, MOS field-effect transistors, and bipolar junction transistors are presented. The evaluations include dc parameters, as well as capacitive variations and noise evaluations. The tests are made at the low current and voltage levels (in particular, at currents ≤1 mA) that are essential for the low-power regimes required by SSC circuitry. Detailed noise data are presented both before and after 5-Mrad (gamma) total-dose exposure. SPICE radiation models for three high-frequency bipolar processes are compared for a typical charge-sensitive preamplifier

  12. POWER, METALLURGICAL AND CHEMICAL MECHANICAL ENGINEERING THERMOELECTRIC EVENTS IN LIGHT-EMITTING BIPOLAR SEMICONDUCTOR STRUCTURES

    Directory of Open Access Journals (Sweden)

    P. A. Magomedova

    2017-01-01

    Full Text Available Objective. The development of light-emitting bipolar semiconductor structures having a low level of parasitic heat release.Methods. A method for converting thermoelectric heat in bipolar semiconductor structures into optical radiation to divert the excess energy into the environment was developed. At the same time, the cooling effect on thermoelectric junctions remains. Instead of an inertial process of conductive or convective heat transfer, practically instantaneous heat removal from electronic components to the environment takes place.Results. As a result, light-emitting bipolar semiconductor structures will allow more powerful devices with greater speed and degree of integration to be created. It is possible to produce transparent LED matrices with a two-way arrangement of transparent solar cells and mirror metal electrodes along the perimeter. When current is applied, the LED matrix on one of the transitions will absorb thermal energy; on other electrodes, it will emit radiation that is completely recovered into electricity by means of transparent solar cells following repeated reflection between the mirror electrodes. The low efficiency of solar cells will be completely compensated for with the multiple passages of photons through these batteries.Conclusion. Light-emitting bipolar semiconductor structures will not only improve the reliability of electronic components in a wide range of performance characteristics, but also improve energy efficiency through the use of optical radiation recovery. Semiconductor thermoelectric devices using optical phenomena in conjunction with the Peltier effect allow a wide range of energy-efficient components of radio electronic equipment to be realised, both for discrete electronics and for microsystem techniques. Systems for obtaining ultra-low temperatures in order to achieve superconductivity are of particular value. 

  13. Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Leonardo Baldaçara

    Full Text Available ABSTRACT. New evidence suggests that the cerebellum has structural and functional abnormalities in psychiatric disorders. Objective: In this research, the goal was to measure the volume of the cerebellum and its subregions in individuals with psychiatric disorders and to relate these findings to their symptoms. Methods: Patients with different degrees of cognitive impairment (Epidemiology of the Elderly - UNIFESP and patients with post-traumatic stress disorder (PTSD from population studies were analyzed. Also, patients with bipolar disorder from an outpatient clinic (Center for the Study of Mood and Anxiety Disorders, Universidade Federal da Bahia were recruited for this study. All subjects underwent a 1.5T structural magnetic resonance scan. Volumetric measures and symptom measurements, by psychometric scales, were performed and compared between patients and controls. Results: The cerebellum volume was reduced in patients with cognitive impairment without dementia and with dementia, in patients with PTSD, and in patients with bipolar disorder compared to controls. In dementia and PTSD, the left cerebellar hemisphere and vermis volume were reduced. In bipolar disorder, volumes of both hemispheres and the vermis were reduced. In the first two studies, these cerebellar volumetric reductions correlated with symptoms of the disease. Conclusion: The exact nature of cerebellar involvement in mental processes is still not fully understood. However, abnormalities in cerebellar structure and its functions have been reported in some of these diseases. Future studies with larger samples are needed to clarify these findings and investigate whether they are important for treatment and prognosis.

  14. Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder.

    Science.gov (United States)

    Baldaçara, Leonardo; Borgio, João Guilherme Fiorani; Araújo, Célia; Nery-Fernandes, Fabiana; Lacerda, Acioly Luiz Taveres; Moraes, Walter André Dos Santos; Montaño, Maria Beatriz Marcondes Macedo; Rocha, Marlos; Quarantini, Lucas C; Schoedl, Aline; Pupo, Mariana; Mello, Marcelo F; Andreoli, Sergio B; Miranda-Scippa, Angela; Ramos, Luiz Roberto; Mari, Jair J; Bressan, Rodrigo Affonseca; Jackowski, Andrea Parolin

    2012-01-01

    New evidence suggests that the cerebellum has structural and functional abnormalities in psychiatric disorders. In this research, the goal was to measure the volume of the cerebellum and its subregions in individuals with psychiatric disorders and to relate these findings to their symptoms. Patients with different degrees of cognitive impairment (Epidemiology of the Elderly - UNIFESP) and patients with post-traumatic stress disorder (PTSD) from population studies were analyzed. Also, patients with bipolar disorder from an outpatient clinic (Center for the Study of Mood and Anxiety Disorders, Universidade Federal da Bahia) were recruited for this study. All subjects underwent a 1.5T structural magnetic resonance scan. Volumetric measures and symptom measurements, by psychometric scales, were performed and compared between patients and controls. The cerebellum volume was reduced in patients with cognitive impairment without dementia and with dementia, in patients with PTSD, and in patients with bipolar disorder compared to controls. In dementia and PTSD, the left cerebellar hemisphere and vermis volume were reduced. In bipolar disorder, volumes of both hemispheres and the vermis were reduced. In the first two studies, these cerebellar volumetric reductions correlated with symptoms of the disease. The exact nature of cerebellar involvement in mental processes is still not fully understood. However, abnormalities in cerebellar structure and its functions have been reported in some of these diseases. Future studies with larger samples are needed to clarify these findings and investigate whether they are important for treatment and prognosis.

  15. Nine-channel mid-power bipolar pulse generator based on a field programmable gate array

    Energy Technology Data Exchange (ETDEWEB)

    Haylock, Ben, E-mail: benjamin.haylock2@griffithuni.edu.au; Lenzini, Francesco; Kasture, Sachin; Fisher, Paul; Lobino, Mirko [Centre for Quantum Dynamics, Griffith University, Brisbane (Australia); Queensland Micro and Nanotechnology Centre, Griffith University, Brisbane (Australia); Streed, Erik W. [Centre for Quantum Dynamics, Griffith University, Brisbane (Australia); Institute for Glycomics, Griffith University, Gold Coast (Australia)

    2016-05-15

    Many channel arbitrary pulse sequence generation is required for the electro-optic reconfiguration of optical waveguide networks in Lithium Niobate. Here we describe a scalable solution to the requirement for mid-power bipolar parallel outputs, based on pulse patterns generated by an externally clocked field programmable gate array. Positive and negative pulses can be generated at repetition rates up to 80 MHz with pulse width adjustable in increments of 1.6 ns across nine independent outputs. Each channel can provide 1.5 W of RF power and can be synchronised with the operation of other components in an optical network such as light sources and detectors through an external clock with adjustable delay.

  16. Highly conductive, multi-layer composite precursor composition to fuel cell flow field plate or bipolar plate

    Science.gov (United States)

    Jang, Bor Z [Centerville, OH; Zhamu, Aruna [Centerville, OH; Guo, Jiusheng [Centerville, OH

    2011-02-15

    This invention provides a moldable, multiple-layer composite composition, which is a precursor to an electrically conductive composite flow field plate or bipolar plate. In one preferred embodiment, the composition comprises a plurality of conductive sheets and a plurality of mixture layers of a curable resin and conductive fillers, wherein (A) each conductive sheet is attached to at least one resin-filler mixture layer; (B) at least one of the conductive sheets comprises flexible graphite; and (C) at least one resin-filler mixture layer comprises a thermosetting resin and conductive fillers with the fillers being present in a sufficient quantity to render the resulting flow field plate or bipolar plate electrically conductive with a conductivity no less than 100 S/cm and thickness-direction areal conductivity no less than 200 S/cm.sup.2.

  17. Confirmatory factor analysis reveals a latent cognitive structure common to bipolar disorder, schizophrenia, and normal controls.

    Science.gov (United States)

    Schretlen, David J; Peña, Javier; Aretouli, Eleni; Orue, Izaskun; Cascella, Nicola G; Pearlson, Godfrey D; Ojeda, Natalia

    2013-06-01

    We sought to determine whether a single hypothesized latent factor structure would characterize cognitive functioning in three distinct groups. We assessed 576 adults (340 community controls, 126 adults with bipolar disorder, and 110 adults with schizophrenia) using 15 measures derived from nine cognitive tests. Confirmatory factor analysis (CFA) was conducted to examine the fit of a hypothesized six-factor model. The hypothesized factors included attention, psychomotor speed, verbal memory, visual memory, ideational fluency, and executive functioning. The six-factor model provided an excellent fit for all three groups [for community controls, root mean square error of approximation (RMSEA) schizophrenia, RMSEA = 0.06 and CFI = 0.98]. Alternate models that combined fluency with processing speed or verbal and visual memory reduced the goodness of fit. Multi-group CFA results supported factor invariance across the three groups. Confirmatory factor analysis supported a single six-factor structure of cognitive functioning among patients with schizophrenia or bipolar disorder and community controls. While the three groups clearly differ in level of performance, they share a common underlying architecture of information processing abilities. These cognitive factors could provide useful targets for clinical trials of treatments that aim to enhance information processing in persons with neurological and neuropsychiatric disorders. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. The effects of lithium and anticonvulsants on brain structure in bipolar disorder.

    Science.gov (United States)

    Germaná, C; Kempton, M J; Sarnicola, A; Christodoulou, T; Haldane, M; Hadjulis, M; Girardi, P; Tatarelli, R; Frangou, S

    2010-12-01

    To investigate the effect of lithium, anticonvulsants and antipsychotics on brain structure in bipolar disorder (BD). A cross-sectional structural brain magnetic resonance imaging study of 74 remitted patients with BD, aged 18-65, who were receiving long-term prophylactic treatment with lithium or anticonvulsants or antipsychotics. Global and regional grey matter, white matter, and cerebrospinal fluid volumes were compared between treatment groups. Grey matter in the subgenual anterior cingulate gyrus on the right (extending into the hypothalamus) and in the postcentral gyrus, the hippocampus/amygdale complex and the insula on the left was greater in BD patients on lithium treatment compared to all other treatment groups. Lithium treatment in BD has a significant effect on brain structure particularly in limbic/paralimbic regions associated with emotional processing. © 2010 John Wiley & Sons A/S.

  19. BDNF and BMI effects on brain structures of bipolar offspring: results from the global mood and brain science initiative.

    Science.gov (United States)

    Mansur, R B; Brietzke, E; McIntyre, R S; Cao, B; Lee, Y; Japiassú, L; Chen, K; Lu, R; Lu, W; Li, T; Xu, G; Lin, K

    2017-12-01

    To compare brain-derived neurotrophic factor (BDNF) levels between offspring of individuals with bipolar disorders (BD) and healthy controls (HCs) and investigate the effects of BDNF levels and body mass index (BMI) on brain structures. Sixty-seven bipolar offspring and 45 HCs were included (ages 8-28). Structural images were acquired using 3.0 Tesla magnetic resonance imaging. Serum BDNF levels were measured using enzyme-linked immunosorbent assay. Multivariate and univariate analyses of covariance were conducted. Significantly higher BDNF levels were observed among bipolar offspring, relative to HCs (P > 0.025). Offspring status moderated the association between BDNF and BMI (F 1 =4.636, P = 0.034). After adjustment for relevant covariates, there was a trend for a significant interaction of group and BDNF on neuroimaging parameters (Wilks'λ F 56,94 =1.463, P = 0.052), with significant effects on cerebellar white matter and superior and middle frontal regions. Brain volume and BDNF were positively correlated among HCs and negatively correlated among bipolar offspring. Interactions between BDNF and BMI on brain volumes were non-significant among HCs (Wilks'λ F 28,2 =2.229, P = 0.357), but significant among bipolar offspring (Wilks'λ F 28,12 =2.899, P = 0.028). Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  20. Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.

    Science.gov (United States)

    Perry, William; Minassian, Arpi; Henry, Brook; Kincaid, Meegin; Young, Jared W; Geyer, Mark A

    2010-06-30

    It has been suggested that a cardinal symptom of mania is over-activity and exaggerated goal-directed behavior. Nevertheless, few attempts have been made to quantify this behavior objectively in a laboratory environment. Having a methodology to assess over-activity reliably might be useful in distinguishing manic bipolar disorder (BD) from schizophrenia (SCZ) during highly activated states. In the current study, quantifiable measures of object interaction were assessed using a multivariate approach. Additionally, symptom correlates of over-activity were assessed. Patients admitted to an acute care psychiatric hospital for either BD with mania or SCZ (paranoid and non-paranoid subtypes) as well as non-patient comparison (NC) participants were assessed in an open field setting referred to as the human Behavioral Pattern Monitor (hBPM). Activity and interactions with novel and engaging objects were recorded for 15min via a concealed video camera and rated for exploratory behavior. Both BD and SCZ patients spent more time near the objects and exhibited more overall walking compared to NC. In contrast, BD patients exhibited greater physical contact with objects (number of object interactions and time spent with objects) relative to SCZ patients or NC participants, as well as more perseverative and socially disinhibited behaviors, indicating a unique pattern of over-activity and goal-directed behavior. Further analyses revealed a distinction between SCZ patients according to their subtype. The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ.

  1. Relation between Amygdala Structure and Function in Adolescents with Bipolar Disorder

    Science.gov (United States)

    Kalmar, Jessica H.; Wang, Fei; Chepenik, Lara G.; Womer, Fay Y.; Jones, Monique M.; Pittman, Brian; Shah, Maulik P.; Martin, Andres; Constable, R. Todd; Blumberg, Hilary P.

    2009-01-01

    Adolescents with bipolar disorder showed decreased amygdala volume and increased amygdala response to emotional faces. Amygdala volume is inversely related to activation during emotional face processing.

  2. Heat Removal from Bipolar Transistor by Loop Heat Pipe with Nickel and Copper Porous Structures

    Directory of Open Access Journals (Sweden)

    Patrik Nemec

    2014-01-01

    Full Text Available Loop heat pipes (LHPs are used in many branches of industry, mainly for cooling of electrical elements and systems. The loop heat pipe is a vapour-liquid phase-change device that transfers heat from evaporator to condenser. One of the most important parts of the LHP is the porous wick structure. The wick structure provides capillary force to circulate the working fluid. To achieve good thermal performance of LHP, capillary wicks with high permeability and porosity and fine pore radius are expected. The aim of this work was to develop porous structures from copper and nickel powder with different grain sizes. For experiment copper powder with grain size of 50 and 100 μm and nickel powder with grain size of 10 and 25 μm were used. Analysis of these porous structures and LHP design are described in the paper. And the measurements’ influences of porous structures in LHP on heat removal from the insulated gate bipolar transistor (IGBT have been made.

  3. Heat Removal from Bipolar Transistor by Loop Heat Pipe with Nickel and Copper Porous Structures

    Science.gov (United States)

    Smitka, Martin; Malcho, Milan

    2014-01-01

    Loop heat pipes (LHPs) are used in many branches of industry, mainly for cooling of electrical elements and systems. The loop heat pipe is a vapour-liquid phase-change device that transfers heat from evaporator to condenser. One of the most important parts of the LHP is the porous wick structure. The wick structure provides capillary force to circulate the working fluid. To achieve good thermal performance of LHP, capillary wicks with high permeability and porosity and fine pore radius are expected. The aim of this work was to develop porous structures from copper and nickel powder with different grain sizes. For experiment copper powder with grain size of 50 and 100 μm and nickel powder with grain size of 10 and 25 μm were used. Analysis of these porous structures and LHP design are described in the paper. And the measurements' influences of porous structures in LHP on heat removal from the insulated gate bipolar transistor (IGBT) have been made. PMID:24959622

  4. Effect of NiO growth conditions on the bipolar resistance memory switching of Pt/NiO/SRO structure

    International Nuclear Information System (INIS)

    Kurnia, F.; Hadiyawarman, H.; Jung, C. U.; Liu, C. L.; Lee, S. B.; Yang, S. M.; Park, H. W.; Song, S. J.; Hwang, C. S.

    2010-01-01

    We deposited NiO thin films with SrRuO 3 bottom electrodes on SrTiO 3 (001) substrates by using pulsed laser deposition. The growth temperature and the oxygen pressure were varied in order to obtain NiO films with different structural and electrical properties. We investigated the I-V characteristics of the Pt/NiO/SRO structures and observed a strong dependence of bipolar resistance switching on the growth conditions of the NiO thin films. Stable bipolar memory resistance switching was observed only in the devices with NiO films deposited at 400 .deg. C and 10 mTorr of O 2 . The off-state I-V curve of bipolar switching showed a linear fitting to the Schottky effect, indicating its origin in the NiO/SRO interface. Our results suggest that the growth conditions of NiO may affect the bipolar switching behavior through the film's resistance, the film's crystallinity, or the status of the grain boundaries.

  5. Structured-gate organic field-effect transistors

    International Nuclear Information System (INIS)

    Aljada, Muhsen; Pandey, Ajay K; Velusamy, Marappan; Burn, Paul L; Meredith, Paul; Namdas, Ebinazar B

    2012-01-01

    We report the fabrication and electrical characteristics of structured-gate organic field-effect transistors consisting of a gate electrode patterned with three-dimensional pillars. The pillar gate electrode was over-coated with a gate dielectric (SiO 2 ) and solution processed organic semiconductors producing both unipolar p-type and bipolar behaviour. We show that this new structured-gate architecture delivers higher source-drain currents, higher gate capacitance per unit equivalent linear channel area, and enhanced charge injection (electrons and/or holes) versus the conventional planar structure in all modes of operation. For the bipolar field-effect transistor (FET) the maximum source-drain current enhancements in p- and n-channel mode were >600% and 28%, respectively, leading to p and n charge mobilities with the same order of magnitude. Thus, we have demonstrated that it is possible to use the FET architecture to manipulate and match carrier mobilities of material combinations where one charge carrier is normally dominant. Mobility matching is advantageous for creating organic logic circuit elements such as inverters and amplifiers. Hence, the method represents a facile and generic strategy for improving the performance of standard organic semiconductors as well as new materials and blends. (paper)

  6. Structured-gate organic field-effect transistors

    Science.gov (United States)

    Aljada, Muhsen; Pandey, Ajay K.; Velusamy, Marappan; Burn, Paul L.; Meredith, Paul; Namdas, Ebinazar B.

    2012-06-01

    We report the fabrication and electrical characteristics of structured-gate organic field-effect transistors consisting of a gate electrode patterned with three-dimensional pillars. The pillar gate electrode was over-coated with a gate dielectric (SiO2) and solution processed organic semiconductors producing both unipolar p-type and bipolar behaviour. We show that this new structured-gate architecture delivers higher source-drain currents, higher gate capacitance per unit equivalent linear channel area, and enhanced charge injection (electrons and/or holes) versus the conventional planar structure in all modes of operation. For the bipolar field-effect transistor (FET) the maximum source-drain current enhancements in p- and n-channel mode were >600% and 28%, respectively, leading to p and n charge mobilities with the same order of magnitude. Thus, we have demonstrated that it is possible to use the FET architecture to manipulate and match carrier mobilities of material combinations where one charge carrier is normally dominant. Mobility matching is advantageous for creating organic logic circuit elements such as inverters and amplifiers. Hence, the method represents a facile and generic strategy for improving the performance of standard organic semiconductors as well as new materials and blends.

  7. Particle-in-cell simulations of asymmetric guide-field reconnection: quadrupolar structure of Hall magnetic field

    Science.gov (United States)

    Schmitz, R. G.; Alves, M. V.; Barbosa, M. V. G.

    2017-12-01

    One of the most important processes that occurs in Earth's magnetosphere is known as magnetic reconnection (MR). This process can be symmetric or asymmetric, depending basically on the plasma density and magnetic field in both sides of the current sheet. A good example of symmetric reconnection in terrestrial magnetosphere occurs in the magnetotail, where these quantities are similar on the north and south lobes. In the dayside magnetopause MR is asymmetric, since the plasma regimes and magnetic fields of magnetosheath and magnetosphere are quite different. Symmetric reconnection has some unique signatures. For example, the formation of a quadrupolar structure of Hall magnetic field and a bipolar Hall electric field that points to the center of the current sheet. The different particle motions in the presence of asymmetries change these signatures, causing the quadrupolar pattern to be distorted and forming a bipolar structure. Also, the bipolar Hall electric field is modified and gives rise to a single peak pointing toward the magnetosheat, considering an example of magnetopause reconnection. The presence of a guide-field can also distort the quadrupolar pattern, by giving a shear angle across the current sheet and altering the symmetric patterns, according to previous simulations and observations. Recently, a quadrupolar structure was observed in an asymmetric guide-field MR event using MMS (Magnetospheric Multiscale) mission data [Peng et al., JGR, 2017]. This event shows clearly that the density asymmetry and the guide-field were not sufficient to form signatures of asymmetric reconnection. Using the particle-in-cell code iPIC3D [Markidis et al, Mathematics and Computers in Simulation, 2010] with the MMS data from this event used to define input parameters, we found a quadrupolar structure of Hall magnetic field and a bipolar pattern of Hall electric field in ion scales, showing that our results are in an excellent agreement with the MMS observations. To our

  8. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder.

    Science.gov (United States)

    Johnston, Jennifer A Y; Wang, Fei; Liu, Jie; Blond, Benjamin N; Wallace, Amanda; Liu, Jiacheng; Spencer, Linda; Cox Lippard, Elizabeth T; Purves, Kirstin L; Landeros-Weisenberger, Angeli; Hermes, Eric; Pittman, Brian; Zhang, Sheng; King, Robert; Martin, Andrés; Oquendo, Maria A; Blumberg, Hilary P

    2017-07-01

    Bipolar disorder is associated with high risk for suicidal behavior that often develops in adolescence and young adulthood. Elucidation of involved neural systems is critical for prevention. This study of adolescents and young adults with bipolar disorder with and without a history of suicide attempts combines structural, diffusion tensor, and functional MR imaging methods to investigate implicated abnormalities in the morphology and structural and functional connectivity within frontolimbic systems. The study had 26 participants with bipolar disorder who had a prior suicide attempt (the attempter group) and 42 participants with bipolar disorder without a suicide attempt (the nonattempter group). Regional gray matter volume, white matter integrity, and functional connectivity during processing of emotional stimuli were compared between groups, and differences were explored for relationships between imaging modalities and associations with suicide-related symptoms and behaviors. Compared with the nonattempter group, the attempter group showed significant reductions in gray matter volume in the orbitofrontal cortex, hippocampus, and cerebellum; white matter integrity in the uncinate fasciculus, ventral frontal, and right cerebellum regions; and amygdala functional connectivity to the left ventral and right rostral prefrontal cortex. In exploratory analyses, among attempters, there was a significant negative correlation between right rostral prefrontal connectivity and suicidal ideation and between left ventral prefrontal connectivity and attempt lethality. Adolescent and young adult suicide attempters with bipolar disorder demonstrate less gray matter volume and decreased structural and functional connectivity in a ventral frontolimbic neural system subserving emotion regulation. Among attempters, reductions in amygdala-prefrontal functional connectivity may be associated with severity of suicidal ideation and attempt lethality.

  9. The electromagnetic radiation fields of a relativistic electron avalanche with special attention to the origin of narrow bipolar pulses

    Science.gov (United States)

    Cooray, G. V.; Cooray, G. K.

    2011-12-01

    Gurevich et al. [1] postulated that the source of narrow bipolar pulses, a class of high energy pulses that occur during thunderstorms, could be a runaway electron avalanche driven by the intense electric fields of a thunderstorm. Recently, Watson and Marshall [2] used the modified transmission line model to test the mechanism of the source of narrow bipolar pulses. In a recent paper, Cooray and Cooray [3] demonstrated that the electromagnetic fields of accelerating charges could be used to evaluate the electromagnetic fields from electrical discharges if the temporal and spatial variation of the charges in the discharge is known. In the present study, those equations were utilized to evaluate the electromagnetic fields generated by a relativistic electron avalanche. In the analysis it is assumed that all the electrons in the avalanche are moving with the same speed. In other words, the growth or the decay of the number of electrons takes place only at the head of the avalanche. It is shown that the radiation is emanating only from the head of the avalanche where electrons are being accelerated. It is also shown that an analytical expression for the radiation field of the avalanche at any distance can be written directly in terms of the e-folding length of the avalanche. This makes it possible to extract directly the spatial variation of the e-folding length of the avalanche from the measured radiation fields. In the study this model avalanche was used to investigate whether it can be used to describe the measured electromagnetic fields of narrow bipolar pulses. The results obtained are in reasonable agreement with the two station data of Eack [4] for speeds of propagation around (2 - 2.5) x 10^8 m/s and when the propagation effects on the electric fields measured at the distant station is taken into account. [1] Gurevich et al. (2004), Phys. Lett. A., 329, pp. 348 -361. [2] Watson, S. S. and T. C. Marshall (2007), Geophys. Res. Lett., Vol. 34, L04816, doi: 10

  10. Quantifying over-activity in bipolar and schizophrenia patients in a human open field Paradigm

    OpenAIRE

    Perry, William; Minassian, Arpi; Henry, Brook; Kincaid, Meegin; Young, Jared W.; Geyer, Mark A.

    2010-01-01

    It has been suggested that a cardinal symptom of mania is over-activity and exaggerated goal-directed behavior. Nevertheless, few attempts have been made to quantify this behavior objectively in a laboratory environment. Having a methodology to assess over-activity reliably might be useful in distinguishing manic bipolar disorder (BD) from schizophrenia (SCZ) during highly activated states. In the current study, quantifiable measures of object-interaction were assessed using a multivariate ...

  11. Bipolar resistive switching in graphene oxide based metal insulator metal structure for non-volatile memory applications

    Science.gov (United States)

    Singh, Rakesh; Kumar, Ravi; Kumar, Anil; Kashyap, Rajesh; Kumar, Mukesh; Kumar, Dinesh

    2018-05-01

    Graphene oxide based devices have attracted much attention recently because of their possible application in next generation electronic devices. In this study, bipolar resistive switching characteristics of graphene oxide based metal insulator metal structure were investigated for nonvolatile memories. The graphene oxide was prepared by the conventional Hummer's method and deposited on ITO coated glass by spin-coating technique. The dominant mechanism of resistive switching is the formation and rupture of the conductive filament inside the graphene oxide. The conduction mechanism for low and high resistance states are dominated by two mechanism the ohmic conduction and space charge limited current (SCLC) mechanism, respectively. Atomic Force Microscopy, X-ray diffraction, Cyclic-Voltammetry were conducted to observe the morphology, structure and behavior of the material. The fabricated device with Al/GO/ITO structure exhibited reliable bipolar resistive switching with set & reset voltage of -2.3 V and 3V respectively.

  12. Elimination of image flicker in a fringe-field switching liquid crystal display by applying a bipolar voltage wave.

    Science.gov (United States)

    Oh, Seung-Won; Park, Jun-Hee; Lee, Ji-Hoon; Yoon, Tae-Hoon

    2015-09-07

    Recently, low-frequency driving of liquid crystal display (LCD) panels to minimize power consumption has drawn much attention. In the case in which an LCD panel is driven by a fringe-field at a low frequency, the image flickering phenomenon occurs when the sign of the applied electric field is reversed. We investigated image flickering induced by the flexoelectric effect in a fringe-field switching (FFS) liquid crystal cell in terms of the transmittance difference between frames and the ripple phenomenon. Experimental results show that image flicker due to transmittance difference can be eliminated completely and that the ripple phenomena can be reduced significantly by applying a bipolar voltage wave to the FFS cell.

  13. Structural and functional changes in the somatosensory cortex in euthymic females with bipolar disorder.

    Science.gov (United States)

    Minuzzi, Luciano; Syan, Sabrina K; Smith, Mara; Hall, Alexander; Hall, Geoffrey Bc; Frey, Benicio N

    2017-12-01

    Current evidence from neuroimaging data suggests possible dysfunction of the fronto-striatal-limbic circuits in individuals with bipolar disorder. Somatosensory cortical function has been implicated in emotional recognition, risk-taking and affective responses through sensory modalities. This study investigates anatomy and function of the somatosensory cortex in euthymic bipolar women. In total, 68 right-handed euthymic women (bipolar disorder = 32 and healthy controls = 36) between 16 and 45 years of age underwent high-resolution anatomical and functional magnetic resonance imaging during the mid-follicular menstrual phase. The somatosensory cortex was used as a seed region for resting-state functional connectivity analysis. Voxel-based morphometry was used to evaluate somatosensory cortical gray matter volume between groups. We found increased resting-state functional connectivity between the somatosensory cortex and insular cortex, inferior prefrontal gyrus and frontal orbital cortex in euthymic bipolar disorder subjects compared to healthy controls. Voxel-based morphometry analysis showed decreased gray matter in the left somatosensory cortex in the bipolar disorder group. Whole-brain voxel-based morphometry analysis controlled by age did not reveal any additional significant difference between groups. This study is the first to date to evaluate anatomy and function of the somatosensory cortex in a well-characterized sample of euthymic bipolar disorder females. Anatomical and functional changes in the somatosensory cortex in this population might contribute to the pathophysiology of bipolar disorder.

  14. Laminated exfoliated graphite composite-metal compositions for fuel cell flow field plate or bipolar plate applications

    Science.gov (United States)

    Zhamu, Aruna; Shi, Jinjun; Guo, Jiusheng; Jang, Bor Z

    2014-05-20

    An electrically conductive laminate composition for fuel cell flow field plate or bipolar plate applications. The laminate composition comprises at least a thin metal sheet having two opposed exterior surfaces and a first exfoliated graphite composite sheet bonded to the first of the two exterior surfaces of the metal sheet wherein the exfoliated graphite composite sheet comprises: (a) expanded or exfoliated graphite and (b) a binder or matrix material to bond the expanded graphite for forming a cohered sheet, wherein the binder or matrix material is between 3% and 60% by weight based on the total weight of the first exfoliated graphite composite sheet. Preferably, the first exfoliated graphite composite sheet further comprises particles of non-expandable graphite or carbon in the amount of between 3% and 60% by weight based on the total weight of the non-expandable particles and the expanded graphite. Further preferably, the laminate comprises a second exfoliated graphite composite sheet bonded to the second surface of the metal sheet to form a three-layer laminate. Surface flow channels and other desired geometric features can be built onto the exterior surfaces of the laminate to form a flow field plate or bipolar plate. The resulting laminate has an exceptionally high thickness-direction conductivity and excellent resistance to gas permeation.

  15. Structural brain network analysis in families multiply affected with bipolar I disorder.

    Science.gov (United States)

    Forde, Natalie J; O'Donoghue, Stefani; Scanlon, Cathy; Emsell, Louise; Chaddock, Chris; Leemans, Alexander; Jeurissen, Ben; Barker, Gareth J; Cannon, Dara M; Murray, Robin M; McDonald, Colm

    2015-10-30

    Disrupted structural connectivity is associated with psychiatric illnesses including bipolar disorder (BP). Here we use structural brain network analysis to investigate connectivity abnormalities in multiply affected BP type I families, to assess the utility of dysconnectivity as a biomarker and its endophenotypic potential. Magnetic resonance diffusion images for 19 BP type I patients in remission, 21 of their first degree unaffected relatives, and 18 unrelated healthy controls underwent tractography. With the automated anatomical labelling atlas being used to define nodes, a connectivity matrix was generated for each subject. Network metrics were extracted with the Brain Connectivity Toolbox and then analysed for group differences, accounting for potential confounding effects of age, gender and familial association. Whole brain analysis revealed no differences between groups. Analysis of specific mainly frontal regions, previously implicated as potentially endophenotypic by functional magnetic resonance imaging analysis of the same cohort, revealed a significant effect of group in the right medial superior frontal gyrus and left middle frontal gyrus driven by reduced organisation in patients compared with controls. The organisation of whole brain networks of those affected with BP I does not differ from their unaffected relatives or healthy controls. In discreet frontal regions, however, anatomical connectivity is disrupted in patients but not in their unaffected relatives. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  16. The relationship between genetic risk variants with brain structure and function in bipolar disorder

    DEFF Research Database (Denmark)

    Pereira, Licia P; Köhler, Cristiano A; de Sousa, Rafael T

    2017-01-01

    Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases fro...

  17. BUBBLES AND KNOTS IN THE KINEMATICAL STRUCTURE OF THE BIPOLAR PLANETARY NEBULA NGC 2818

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez, Roberto, E-mail: vazquez@astro.unam.mx [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Km 103 Carretera Tijuana-Ensenada, 22860 Ensenada, BC (Mexico)

    2012-06-01

    High-resolution Hubble Space Telescope archive imaging and high-dispersion spectroscopy are used to study the complex morphological and kinematical structure of the planetary nebula, NGC 2818. We analyze narrowband H{alpha}, [O III], [N II], [S II], and He II images, addressing important morphological features. Ground-based long-slit echelle spectra were obtained crossing NGC 2818 at five different positions to precisely determine kinematical features in the structure of the nebula. A distance of 2.5 kpc was used to determine physical scales. Constructing models to fit the data with modern computational tools, we find NGC 2818 is composed of (1) a non-uniform bipolar structure with a semimajor axis of 0.92 pc (75''), possibly deformed by the stellar wind, (2) a 0.17 pc (14'') diameter central region, which is potentially the remnant of an equatorial enhancement, and (3) a great number of cometary knots. These knots are preferentially located inside a radius of 0.24 pc (20'') around the central star. The major axis of the main structure is oriented at i {approx_equal} 60 Degree-Sign with respect to the line of sight and at P.A. = +89 Degree-Sign on the plane of the sky. Expansion velocities of this nebula are V{sub pol} = 105 km s{sup -1} and V{sub eq} = 20 km s{sup -1}, which lead to our estimate of the kinematical age of {tau}{sub k} {approx_equal} 8400 {+-} 3400 yr (assuming homologous expansion). Our observations do not support the idea that high-velocity collimated ejections are responsible for the formation of microstructures inside the nebula. We determine the systemic velocity of NGC 2818 to be V{sub HEL} = +26 {+-} 2 km s{sup -1}.

  18. Differentiating between bipolar and unipolar depression in functional and structural MRI studies.

    Science.gov (United States)

    Han, Kyu-Man; De Berardis, Domenico; Fornaro, Michele; Kim, Yong-Ku

    2018-03-28

    Distinguishing depression in bipolar disorder (BD) from unipolar depression (UD) solely based on clinical clues is difficult, which has led to the exploration of promising neural markers in neuroimaging measures for discriminating between BD depression and UD. In this article, we review structural and functional magnetic resonance imaging (MRI) studies that directly compare UD and BD depression based on neuroimaging modalities including functional MRI studies on regional brain activation or functional connectivity, structural MRI on gray or white matter morphology, and pattern classification analyses using a machine learning approach. Numerous studies have reported distinct functional and structural alterations in emotion- or reward-processing neural circuits between BD depression and UD. Different activation patterns in neural networks including the amygdala, anterior cingulate cortex (ACC), prefrontal cortex (PFC), and striatum during emotion-, reward-, or cognition-related tasks have been reported between BD and UD. A stronger functional connectivity pattern in BD was pronounced in default mode and in frontoparietal networks and brain regions including the PFC, ACC, parietal and temporal regions, and thalamus compared to UD. Gray matter volume differences in the ACC, hippocampus, amygdala, and dorsolateral prefrontal cortex (DLPFC) have been reported between BD and UD, along with a thinner DLPFC in BD compared to UD. BD showed reduced integrity in the anterior part of the corpus callosum and posterior cingulum compared to UD. Several studies performed pattern classification analysis using structural and functional MRI data to distinguish between UD and BD depression using a supervised machine learning approach, which yielded a moderate level of accuracy in classification. Copyright © 2018 Elsevier Inc. All rights reserved.

  19. Bipolar Disorder

    Science.gov (United States)

    Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go ... The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. ...

  20. On Developing Field-Effect-Tunable Nanofluidic Ion Diodes with Bipolar, Induced-Charge Electrokinetics

    Directory of Open Access Journals (Sweden)

    Ye Tao

    2018-04-01

    Full Text Available We introduce herein the induced-charge electrokinetic phenomenon to nanometer fluidic systems; the design of the nanofluidic ion diode for field-effect ionic current control of the nanometer dimension is developed by enhancing internal ion concentration polarization through electrochemical transport of inhomogeneous inducing-counterions resulting from double gate terminals mounted on top of a thin dielectric layer, which covers the nanochannel connected to microfluidic reservoirs on both sides. A mathematical model based on the fully-coupled Poisson-Nernst-Plank-Navier-Stokes equations is developed to study the feasibility of this structural configuration causing effective ionic current rectification. The effect of various physiochemical and geometrical parameters, such as the native surface charge density on the nanochannel sidewalls, the number of gate electrodes (GE, the gate voltage magnitude, and the solution conductivity, permittivity, and thickness of the dielectric coating, as well as the size and position of the GE pair of opposite gate polarity, on the resulted rectification performance of the presented nanoscale ionic device is numerically analyzed by using a commercial software package, COMSOL Multiphysics (version 5.2. Three types of electrohydrodynamic flow, including electroosmosis of 1st kind, induced-charge electroosmosis, and electroosmosis of 2nd kind that were originated by the Coulomb force within three distinct charge layers coexist in the micro/nanofluidic hybrid network and are shown to simultaneously influence the output current flux in a complex manner. The rectification factor of a contrast between the ‘on’ and ‘off’ working states can even exceed one thousand-fold in the case of choosing a suitable combination of several key parameters. Our demonstration of field-effect-tunable nanofluidic ion diodes of double external gate electrodes proves invaluable for the construction of a flexible electrokinetic platform

  1. Tripolar electric field Structure in guide field magnetic reconnection

    OpenAIRE

    S. Fu; S. Huang; M. Zhou; B. Ni; X. Deng

    2018-01-01

    It has been shown that the guide field substantially modifies the structure of the reconnection layer. For instance, the Hall magnetic and electric fields are distorted in guide field reconnection compared to reconnection without guide fields (i.e., anti-parallel reconnection). In this paper, we performed 2.5-D electromagnetic full particle simulation to study the electric field structures in magnetic reconnection under different initial guide fields (Bg). Once the amplit...

  2. Bipolar disorders

    DEFF Research Database (Denmark)

    Vieta, Eduard; Berk, Michael; Schulze, Thomas G

    2018-01-01

    Bipolar disorders are chronic and recurrent disorders that affect >1% of the global population. Bipolar disorders are leading causes of disability in young people as they can lead to cognitive and functional impairment and increased mortality, particularly from suicide and cardiovascular disease...... and accurate diagnosis is difficult in clinical practice as the onset of bipolar disorder is commonly characterized by nonspecific symptoms, mood lability or a depressive episode, which can be similar in presentation to unipolar depression. Moreover, patients and their families do not always understand...... a bipolar disorder from other conditions. Optimal early treatment of patients with evidence-based medication (typically mood stabilizers and antipsychotics) and psychosocial strategies is necessary....

  3. Anisotropic magnetism in field-structured composites

    International Nuclear Information System (INIS)

    Martin, James E.; Venturini, Eugene; Odinek, Judy; Anderson, Robert A.

    2000-01-01

    Magnetic field-structured composites (FSCs) are made by structuring magnetic particle suspensions in uniaxial or biaxial (e.g., rotating) magnetic fields, while polymerizing the suspending resin. A uniaxial field produces chainlike particle structures, and a biaxial field produces sheetlike particle structures. In either case, these anisotropic structures affect the measured magnetic hysteresis loops, with the magnetic remanence and susceptibility increased significantly along the axis of the structuring field, and decreased slightly orthogonal to the structuring field, relative to the unstructured particle composite. The coercivity is essentially unaffected by structuring. We present data for FSCs of magnetically soft particles, and demonstrate that the altered magnetism can be accounted for by considering the large local fields that occur in FSCs. FSCs of magnetically hard particles show unexpectedly large anisotropies in the remanence, and this is due to the local field effects in combination with the large crystalline anisotropy of this material. (c) 2000 The American Physical Society

  4. Bipolar Disorder.

    Science.gov (United States)

    Spearing, Melissa

    Bipolar disorder, a brain disorder that causes unusual shifts in a person's mood, affects approximately one percent of the population. It commonly occurs in late adolescence and is often unrecognized. The diagnosis of bipolar disorder is made on the basis of symptoms, course of illness, and when possible, family history. Thoughts of suicide are…

  5. Structural brain alterations in bipolar disorder II: a combined voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) study.

    Science.gov (United States)

    Ambrosi, Elisa; Rossi-Espagnet, Maria Camilla; Kotzalidis, Georgios D; Comparelli, Anna; Del Casale, Antonio; Carducci, Filippo; Romano, Andrea; Manfredi, Giovanni; Tatarelli, Roberto; Bozzao, Alessandro; Girardi, Paolo

    2013-09-05

    Brain structural changes have been described in bipolar disorder (BP), but usually studies focused on both I and II subtypes indiscriminately and investigated changes in either brain volume or white matter (WM) integrity. We used combined voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) analysis to track changes in the grey matter (GM) and WM in the brains of patients affected by BPII, as compared to healthy controls. Using VBM and DTI, we scanned 20 DSM-IV-TR BPII patients in their euthymic phase and 21 healthy, age- and gender-matched volunteers with no psychiatric history. VBM showed decreases in GM of BPII patients, compared to controls, which were diffuse in nature and most prominent in the right middle frontal gyrus and in the right superior temporal gurus. DTI showed significant and widespread FA reduction in BPII patients in all major WM tracts, including cortico-cortical association tracts. The small sample size limits the generalisability of our findings. Reduced GM volumes and WM integrity changes in BPII patients are not prominent like those previously reported in bipolar disorder type-I and involve cortical structures and their related association tracts. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Bipolar characteristics of AlGaN/AlN/GaN/AlGaN double heterojunction structure with AlGaN as buffer layer

    International Nuclear Information System (INIS)

    Peng, Enchao; Wang, Xiaoliang; Xiao, Hongling; Wang, Cuimei; Yin, Haibo; Chen, Hong; Feng, Chun; Jiang, Lijuan; Hou, Xun; Wang, Zhanguo

    2013-01-01

    Highlights: •2DEG and 2DHG coexist in the AlGaN/AlN/GaN/AlGaN DH-structure. •The sheet densities of 2DEG and 2DHG vary with buffer Al content and GaN thickness. •The conditions for the disappearance of 2DHG are discussed. •Increasing buffer Al content provides better electron confinement. •Dislocation scattering is reduced in the DH-structure. -- Abstract: This is a theoretical study of AlGaN/AlN/GaN/AlGaN double heterojunction (DH) structure with AlGaN as buffer layer. Our calculation shows that as the buffer Al content increases, though two-dimensional electron gas (2DEG) sheet density decreases, the channel back-barrier caused by polarization-induced electric field in GaN provides better electron confinement. And under certain conditions the DH-structure shows bipolar characteristics, with an additional two-dimensional hole gas (2DHG) formed at GaN/AlGaN interface. The influence of the buffer Al content and GaN channel thickness on the 2DEG and 2DHG sheet densities are investigated, and the conditions for the disappearance of 2DHG are discussed. Also, the mobility inhibited by dislocation scattering is enhanced in DH-structure due to the enhancement of screening effect of the 2DEG

  7. Correlations between brain structure and symptom dimensions of psychosis in schizophrenia, schizoaffective, and psychotic bipolar I disorders.

    Science.gov (United States)

    Padmanabhan, Jaya L; Tandon, Neeraj; Haller, Chiara S; Mathew, Ian T; Eack, Shaun M; Clementz, Brett A; Pearlson, Godfrey D; Sweeney, John A; Tamminga, Carol A; Keshavan, Matcheri S

    2015-01-01

    Structural alterations may correlate with symptom severity in psychotic disorders, but the existing literature on this issue is heterogeneous. In addition, it is not known how cortical thickness and cortical surface area correlate with symptom dimensions of psychosis. Subjects included 455 individuals with schizophrenia, schizoaffective, or bipolar I disorders. Data were obtained as part of the Bipolar Schizophrenia Network for Intermediate Phenotypes study. Diagnosis was made through the Structured Clinical Interview for DSM-IV. Positive and negative symptom subscales were assessed using the Positive and Negative Syndrome Scale. Structural brain measurements were extracted from T1-weight structural MRIs using FreeSurfer v5.1 and were correlated with symptom subscales using partial correlations. Exploratory factor analysis was also used to identify factors among those regions correlating with symptom subscales. The positive symptom subscale correlated inversely with gray matter volume (GMV) and cortical thickness in frontal and temporal regions, whereas the negative symptom subscale correlated inversely with right frontal cortical surface area. Among regions correlating with the positive subscale, factor analysis identified four factors, including a temporal cortical thickness factor and frontal GMV factor. Among regions correlating with the negative subscale, factor analysis identified a frontal GMV-cortical surface area factor. There was no significant diagnosis by structure interactions with symptom severity. Structural measures correlate with positive and negative symptom severity in psychotic disorders. Cortical thickness demonstrated more associations with psychopathology than cortical surface area. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  8. On the field-to-current conversion factors for large bipolar lightning discharge events in winter thunderstorms in Japan

    Science.gov (United States)

    Chen, Long; Zhang, Qilin; Hou, Wenhao; Tao, Yulang

    2015-07-01

    In this paper we have simulated the far-field waveform characteristic of large bipolar events (LBEs) occurred in winter thunderstorms in Japan and compared the field-to-current conversion factors (FCCFs) of LBEs with that of the lightning cloud-to-ground (CG) return stroke (RS) in summer thunderstorm. As for the physical process of LBEs, Wu et al. (2014) considered that LBEs may be very similar to the typical lightning RS (RS-like process) or caused by an initial continuous current pulse (ICC-like process) in upward lightning flashes. We assume that the lightning channel length of LBEs ranges from 500 m to 1000 m, and the height of tall object struck by LBEs is from 100 m to 300 m. By using the bouncing wave model, we found that only when the injected current waveform of LBEs is characterized with a symmetric Gaussian pulse, the simulated far-field waveform of LBEs both for RS-like process and ICC-like process is similar to that observed by Wu et al. (2014). For striking tall objects with heights from 100 m and 300 m, the FCCFs of LBEs are positively correlated with its channel length and derivatives of injected current waveform, and the FCCF for RS-like process is about similar to that for ICC-like process. However, the FCCFs of LBEs are very different from lightning RS in summer thunderstorm; that is to say, the FCCFs developed for the well-known lightning RS in summer thunderstorm are not suitable for LBEs.

  9. Two-dimensional spatial survey of the plasma potential and electric field in a pulsed bipolar magnetron discharge

    International Nuclear Information System (INIS)

    Vetushka, A.; Karkari, S.K.; Bradley, J.W.

    2004-01-01

    Emissive and Langmuir probe techniques have been used to obtain two-dimensional (2D) spatial maps of the plasma potential V p , electric field E, and ion trajectories in a pulsed bipolar magnetron discharge. The magnetron was pulsed at a frequency of 100 kHz, with a 50% duty cycle and operated at an argon pressure of 0.74 Pa. The pulse wave form was characterized by three distinct phases: the 'overshoot', 'reverse', and 'on' phases. In the 'on' phase of the pulse, when the cathode voltage is driven to -670 V, the 2D spatial distribution of V p has a similar form to that in dc magnetron, with significant axial and radial electric fields in the bulk plasma, accelerating ions to the sheath edge above the cathode racetrack region. During the 'overshoot' phase (duration 200 ns), V p is raised to values greater than +330 V, more than 100 V above the cathode potential, with E pointing away from the target. In the 'reverse' phase V p has a value of +45 V at all measured positions, 2 V more positive than the target potential. In this phase there is no electric field present in the plasma. In the bulk of the plasma, the results from Langmuir probe and the emissive probe are in good agreement, however, in one particular region of the plasma outside the radius of the cathode, the emissive probe measurements are consistently more positive (up to 45 V in the 'on' time). This discrepancy is discussed in terms of the different frequency response of the probes and their perturbation of the plasma. A simple circuit model of the plasma-probe system has been proposed to explain our results. A brief discussion of the effect of the changing plasma potential distribution on the operation of the magnetron is given

  10. Considerations on field problem structure

    International Nuclear Information System (INIS)

    Pavelescu, M.

    1977-01-01

    A survey of the three field problem types known today: equilibrium, eigen value and propagation problems is presented. The place occupied by neutron field in the nuclear reactor systems both statics and dynamics is shown. The special class of approximate solution method concerning the solving of field and boundary equations is analysed. The residual and variational method and the finite element method which presents a special interest are examined as well. (author)

  11. Factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: Implications for genomic studies.

    Science.gov (United States)

    Harvey, Philip D; Aslan, Mihaela; Du, Mengtian; Zhao, Hongyu; Siever, Larry J; Pulver, Ann; Gaziano, J Michael; Concato, John

    2016-01-01

    Impairments in cognition and everyday functioning are common in schizophrenia and bipolar disorder (BPD). In this article, we present factor analyses of cognitive and functional capacity (FC) measures based on 2 studies of schizophrenia (SCZ) and bipolar I disorder (BPI) using similar methods. The overall goal of these analyses was to determine whether performance-based assessments should be examined individually, or aggregated on the basis of the correlational structure of the tests, as well as to evaluate the similarity of factor structures of SCZ and BPI. Veterans Affairs Cooperative Studies Program Study #572 (Harvey et al., 2014) evaluated cognitive and FC measures among 5,414 BPI and 3,942 SCZ patients. A 2nd study evaluated similar neuropsychological (NP) and FC measures among 368 BPI and 436 SCZ patients. Principal components analysis, as well as exploratory and CFAs, were used to examine the data. Analyses in both datasets suggested that NP and FC measures were explained by a single underlying factor in BPI and SCZ patients, both when analyzed separately or as in a combined sample. The factor structure in both studies was similar, with or without inclusion of FC measures; homogeneous loadings were observed for that single factor across cognitive and FC domains across the samples. The empirically derived factor model suggests that NP performance and FC are best explained as a single latent trait applicable to people with SCZ and BPD. This single measure may enhance the robustness of the analyses relating genomic data to performance-based phenotypes. (c) 2015 APA, all rights reserved).

  12. Brain Structure and Function in Women with Comorbid Bipolar and Premenstrual Dysphoric Disorder

    Directory of Open Access Journals (Sweden)

    Sabrina K. Syan

    2018-01-01

    Full Text Available IntroductionHormonal fluctuations associated with female reproductive life events may precipitate or worsen affective episodes in women with bipolar disorder (BD. Previous studies have shown that women with BD report higher rates of premenstrual dysphoric disorder (PMDD than controls. Further, bipolar women who report premenstrual worsening of mood display a worse course of their bipolar illness. Despite this, the neural correlates of comorbid BD and PMDD have not been investigated.MethodologyEighty-five [CTRL, n = 25; PMDD, n = 20; BD, n = 21; BD with comorbid PMDD (BDPMDD, n = 19], regularly cycling women, not on hormonal contraception, underwent two MRI scans: during their mid-follicular and late luteal menstrual phases. We investigated resting-state functional connectivity (Rs-FC, cortical thickness, and subcortical volumes of brain regions associated with the pathophysiology of BD and PMDD between groups, in the mid-follicular and late luteal phases of the menstrual cycle. All BD subjects were euthymic for at least 2 months prior to study entry.ResultsWomen in the BDPMDD group displayed greater disruption in biological rhythms and more subthreshold depressive and anxious symptoms through the menstrual cycle compared to other groups. Rs-FC was increased between the L-hippocampus and R-frontal cortex and decreased between the R-hippocampus and R-premotor cortex in BDPMDD vs. BD (FDR-corrected, p < 0.05. Cortical thickness analysis revealed decreased cortical thickness of the L-pericalcarine, L-superior parietal, R-middle temporal, R-rostral middle frontal, and L-superior frontal, as well as increased cortical thickness of the L-superior temporal gyri in BDPMDD compared to BD. We also found increased left-caudate volume in BDPMDD vs. BD (pCORR < 0.05.ConclusionWomen with BD and comorbid PMDD display a distinct clinical and neurobiological phenotype of BD, which suggests differential sensitivity to endogenous hormones.

  13. CENP-W plays a role in maintaining bipolar spindle structure.

    Directory of Open Access Journals (Sweden)

    Agnieszka Kaczmarczyk

    Full Text Available The CENP-W/T complex was previously reported to be required for mitosis. HeLa cells depleted of CENP-W displayed profound mitotic defects, with mitotic timing delay, disorganized prometaphases and multipolar spindles as major phenotypic consequences. In this study, we examined the process of multipolar spindle formation induced by CENP-W depletion. Depletion of CENP-W in HeLa cells labeled with histone H2B and tubulin fluorescent proteins induced rapid fragmentation of originally bipolar spindles in a high proportion of cells. CENP-W depletion was associated with depletion of Hec1 at kinetochores. The possibility of promiscuous centrosomal duplication was ruled out by immunofluorescent examination of centrioles. However, centrioles were frequently observed to be abnormally split. In addition, a large proportion of the supernumerary poles lacked centrioles, but were positively stained with different centrosomal markers. These observations suggested that perturbation in spindle force distribution caused by defective kinetochores could contribute to a mechanical mechanism for spindle pole disruption. 'Spindle free' nocodazole arrested cells did not exhibit pole fragmentation after CENP-W depletion, showing that pole fragmentation is microtubule dependent. Inhibition of centrosome separation by monastrol reduced the incidence of spindle pole fragmentation, indicating that Eg5 plays a role in spindle pole disruption. Surprisingly, CENP-W depletion rescued the monopolar spindle phenotype of monastrol treatment, with an increased frequency of bipolar spindles observed after CENP-W RNAi. We overexpressed the microtubule cross-linking protein TPX2 to create spindle poles stabilized by the microtubule cross-linking activity of TPX2. Spindle pole fragmentation was suppressed in a TPX2-dependent fashion. We propose that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction

  14. CENP-W Plays a Role in Maintaining Bipolar Spindle Structure

    Science.gov (United States)

    Kaczmarczyk, Agnieszka; Sullivan, Kevin F.

    2014-01-01

    The CENP-W/T complex was previously reported to be required for mitosis. HeLa cells depleted of CENP-W displayed profound mitotic defects, with mitotic timing delay, disorganized prometaphases and multipolar spindles as major phenotypic consequences. In this study, we examined the process of multipolar spindle formation induced by CENP-W depletion. Depletion of CENP-W in HeLa cells labeled with histone H2B and tubulin fluorescent proteins induced rapid fragmentation of originally bipolar spindles in a high proportion of cells. CENP-W depletion was associated with depletion of Hec1 at kinetochores. The possibility of promiscuous centrosomal duplication was ruled out by immunofluorescent examination of centrioles. However, centrioles were frequently observed to be abnormally split. In addition, a large proportion of the supernumerary poles lacked centrioles, but were positively stained with different centrosomal markers. These observations suggested that perturbation in spindle force distribution caused by defective kinetochores could contribute to a mechanical mechanism for spindle pole disruption. ‘Spindle free’ nocodazole arrested cells did not exhibit pole fragmentation after CENP-W depletion, showing that pole fragmentation is microtubule dependent. Inhibition of centrosome separation by monastrol reduced the incidence of spindle pole fragmentation, indicating that Eg5 plays a role in spindle pole disruption. Surprisingly, CENP-W depletion rescued the monopolar spindle phenotype of monastrol treatment, with an increased frequency of bipolar spindles observed after CENP-W RNAi. We overexpressed the microtubule cross-linking protein TPX2 to create spindle poles stabilized by the microtubule cross-linking activity of TPX2. Spindle pole fragmentation was suppressed in a TPX2-dependent fashion. We propose that CENP-W, by influencing proper kinetochore assembly, particularly microtubule docking sites, can confer spindle pole resistance to traction forces exerted

  15. Multimodal Neuroimaging of Fronto-limbic Structure and Function Associated with Suicide Attempts in Adolescents and Young Adults with Bipolar Disorder

    Science.gov (United States)

    Johnston, Jennifer A. Y.; Wang, Fei; Liu, Jie; Blond, Benjamin N.; Wallace, Amanda; Liu, Jiacheng; Spencer, Linda; Cox Lippard, Elizabeth T.; Purves, Kirstin L.; Landeros-Weisenberger, Angeli; Hermes, Eric; Pittman, Brian; Zhang, Sheng; King, Robert; Martin, Andrés; Oquendo, Maria A.; Blumberg, Hilary P.

    2018-01-01

    Objective Bipolar disorder is associated with high risk for suicide behavior that often develops in adolescence/young adulthood. Elucidation of involved neural systems is critical for prevention. This study of adolescents/young adults with bipolar disorder with and without history of suicide attempts combines structural, diffusion tensor and functional magnetic resonance imaging methods to investigate implicated abnormalities in structural and functional connectivity within fronto-limbic systems. Method Participants with bipolar disorder included 26 with a prior suicide attempt and 42 without attempts. Regional gray matter volume, white matter integrity and functional connectivity during processing of emotional stimuli were compared between groups and differences were explored for relationships between imaging modalities and associations with suicide-related symptoms and behaviors. Results Compared to the non-attempter group, the attempter group showed reductions in gray matter volume in orbitofrontal cortex, hippocampus and cerebellum; white matter integrity in uncinate fasciculus, ventral frontal and right cerebellum regions; and amygdala functional connectivity to left ventral and right rostral prefrontal cortex (pAdolescent/young adult suicide attempters with bipolar disorder demonstrate less gray matter volume and decreased structural and functional connectivity in a ventral fronto-limbic neural system subserving emotion regulation. Among suicide attempters, reductions in amygdala-prefrontal functional connectivity may be associated with severity of suicide ideation and attempt lethality. PMID:28135845

  16. Scientific attitudes towards bipolar disorders

    Directory of Open Access Journals (Sweden)

    Mohammad-Hossein Biglu

    2014-02-01

    Full Text Available Introduction: Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry out day-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, all papers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E database through 2001-2011; second, papers published by the international journal of Bipolar Disorders indexed in SCI-E during a period of 11 years; and third, all papers distributed by the international journal of Bipolar Disorders indexed in MEDLINE during the period of study. Methods: The SCI-E database was used to extract all papers indexed with the topic of Bipolar Disorders as well as all papers published by The International Journal of Bipolar Disorders. Extraction of data from MEDLINE was restricted to the journals name from setting menu. The Science of Science Tool was used to map the co-authorship network of papers published by The International Journal of Bipolar Disorders through 2009-2011. Results: Analysis of data showed that the majority of publications in the subject area of bipolar disorders indexed in SCI-E were published by The International Journal of Bipolar Disorders. Although journal articles consisted of 59% of the total publication type in SCI-E, 65% of publications distributed by The Journal of Bipolar Disorders were in the form of meetingabstracts. Journal articles consisted of only 23% of the total publications. USA was the leading country regarding sharing data in the field of bipolar disorders followed by England, Canada, and Germany. Conclusion: The editorial policy of The International Journal of Bipolar Disorders has been focused on new themes and new ways of researching in the subject area of bipolar disorder. Regarding the selection of papers for indexing, the SCI-E database selects data more comprehensively than MEDLINE. The number of papers

  17. On the Bipolar DC Flow Field-Effect-Transistor for Multifunctional Sample Handing in Microfluidics: A Theoretical Analysis under the Debye–Huckel Limit

    Directory of Open Access Journals (Sweden)

    Weiyu Liu

    2018-02-01

    Full Text Available We present herein a novel method of bipolar field-effect control on DC electroosmosis (DCEO from a physical point of view, in the context of an intelligent and robust operation tool for stratified laminar streams in microscale systems. In this unique design of the DC flow field-effect-transistor (DC-FFET, a pair of face-to-face external gate terminals are imposed with opposite gate-voltage polarities. Diffuse-charge dynamics induces heteropolar Debye screening charge within the diffuse double layer adjacent to the face-to-face oppositely-polarized gates, respectively. A background electric field is applied across the source-drain terminal and forces the face-to-face counterionic charge of reversed polarities into induced-charge electroosmotic (ICEO vortex flow in the lateral direction. The chaotic turbulence of the transverse ICEO whirlpool interacts actively with the conventional plug flow of DCEO, giving rise to twisted streamlines for simultaneous DCEO pumping and ICEO mixing of fluid samples along the channel length direction. A mathematical model in thin-layer approximation and the low-voltage limit is subsequently established to test the feasibility of the bipolar DC-FFET configuration in electrokinetic manipulation of fluids at the micrometer dimension. According to our simulation analysis, an integrated device design with two sets of side-by-side, but upside-down gate electrode pair exhibits outstanding performance in electroconvective pumping and mixing even without any externally-applied pressure difference. Moreover, a paradigm of a microdevice for fully electrokinetics-driven analyte treatment is established with an array of reversed bipolar gate-terminal pairs arranged on top of the dielectric membrane along the channel length direction, from which we can obtain almost a perfect liquid mixture by using a smaller magnitude of gate voltages for causing less detrimental effects at a small Dukhin number. Sustained by theoretical

  18. Magnetostriction of field-structured magnetoelastomers.

    Energy Technology Data Exchange (ETDEWEB)

    Gulley, Gerald L. (Dominican University, River Forest, IL); Read, Douglas H.; Martin, James Ellis; Huber, Dale L.; Anderson, Robert Alan; Frankamp, Benjamin L.

    2005-12-01

    Field-structured magnetic particle composites are an important new class of materials that have great potential as both sensors and actuators. These materials are synthesized by suspending magnetic particles in a polymeric resin and subjecting these to magnetic fields while the resin polymerizes. If a simple uniaxial magnetic field is used, the particles will form chains, yielding composites whose magnetic susceptibility is enhanced along a single direction. A biaxial magnetic field, comprised of two orthogonal ac fields, forms particle sheets, yielding composites whose magnetic susceptibility is enhanced along two principal directions. A balanced triaxial magnetic field can be used to enhance the susceptibility in all directions, and biased heterodyned triaxial magnetic fields are especially effective for producing composites with a greatly enhanced susceptibility along a single axis. Magnetostriction is quadratic in the susceptibility, so increasing the composite susceptibility is important to developing actuators that function well at modest fields. To investigate magnetostriction in these field-structured composites we have constructed a sensitive, constant-stress apparatus capable of 1 ppm strain resolution. The sample geometry is designed to minimize demagnetizing field effects. With this apparatus we have demonstrated field-structured composites with nearly 10,000 ppm strain.

  19. Bipolar Disorder

    Science.gov (United States)

    ... one or other traumatic event Drug or alcohol abuse Complications Left untreated, bipolar disorder can result in serious problems that affect every area of your life, such as: Problems related to drug and alcohol use Suicide or suicide attempts Legal or financial problems Damaged ...

  20. Discharge dynamics of self-oriented microplasma coupling between cross adjacent cavities in micro-structure device driven by a bipolar pulse waveform

    Science.gov (United States)

    Wang, Yaogong; Zhang, Xiaoning; Liu, Lingguang; Zhou, Xuan; Liu, Chunliang; Zhang, Qiaogen

    2018-04-01

    The excitation dynamics and self-oriented plasma coupling of a micro-structure plasma device with a rectangular cross-section are investigated. The device consists of 7 × 7 microcavity arrays, which are blended into a unity by a 50 μm-thick bulk area above them. The device is operated in argon with a pressure of 200 Torr, driven by a bipolar pulse waveform of 20 kHz. The discharge evolution is characterized by means of electrical measurements and optical emission profiles. It has been found that different emission patterns are observed within microcavities. The formation of these patterns induced by the combined action between the applied electric field and surface deactivation is discussed. The microplasma distribution in some specific regions along the diagonal direction of cavities in the bulk area is observed, and self-oriented microplasma coupling is explored, while the plasma interaction occurred between cross adjacent cavities, contributed by the ionization wave propagation. The velocity of ionization wave propagation is measured to be 1.2 km/s to 3.5 km/s. The exploration of this plasma interaction in the bulk area is of value to applications in electromagnetics and signal processing.

  1. Field emission from finite barrier quantum structures

    Energy Technology Data Exchange (ETDEWEB)

    Biswas Sett, Shubhasree, E-mail: shubhasree24@gmail.com [The Institution of Engineers - India, 8, Gokhale Road, Kolkata 700 020 (India); Bose, Chayanika, E-mail: chayanikab@ieee.org [Electronics and Telecommunication Engg. Dept., Jadavpur University, Kolkata 700 032 (India)

    2014-10-01

    We study field emission from various finite barrier quasi-low dimensional structures, taking image force into account. To proceed, we first formulate an expression for field emission current density from a quantum dot. Transverse dimensions of the dot are then increased in turn, to obtain current densities respectively from quantum wire and quantum well with infinite potential energy barriers. To find out field emission from finite barrier structures, the above analysis is followed with a correction in the energy eigen values. In course, variations of field emission current density with strength of the applied electric field and structure dimensions are computed considering n-GaAs and n-GaAs/Al{sub x}Ga{sub 1−x}As as the semiconductor materials. In each case, the current density is found to increase exponentially with the applied field, while it oscillates with structure dimensions. The magnitude of the emission current is less when the image force is not considered, but retains the similar field dependence. In all cases, the field emission from infinite barrier structures exceeds those from respective finite barrier ones.

  2. Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders.

    Science.gov (United States)

    He, Hao; Sui, Jing; Du, Yuhui; Yu, Qingbao; Lin, Dongdong; Drevets, Wayne C; Savitz, Jonathan B; Yang, Jian; Victor, Teresa A; Calhoun, Vince D

    2017-12-01

    Bipolar disorder (BD) and major depressive disorder (MDD) share similar clinical characteristics that often obscure the diagnostic distinctions between their depressive conditions. Both functional and structural brain abnormalities have been reported in these two disorders. However, the direct link between altered functioning and structure in these two diseases is unknown. To elucidate this relationship, we conducted a multimodal fusion analysis on the functional network connectivity (FNC) and gray matter density from MRI data from 13 BD, 40 MDD, and 33 matched healthy controls (HC). A data-driven fusion method called mCCA+jICA was used to identify the co-altered FNC and gray matter components. Comparing to HC, BD exhibited reduced gray matter density in the parietal and occipital cortices, which correlated with attenuated functional connectivity within sensory and motor networks, as well as hyper-connectivity in regions that are putatively engaged in cognitive control. In addition, lower gray matter density was found in MDD in the amygdala and cerebellum. High accuracy in discriminating across groups was also achieved by trained classification models, implying that features extracted from the fusion analysis hold the potential to ultimately serve as diagnostic biomarkers for mood disorders.

  3. Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently?

    Science.gov (United States)

    ... The diagnosis and management of bipolar I and bipolar II disorders: Clinical practice update. Mayo Clinic Proceedings. 2017;92:1532. Haynes PL, et al. Social rhythm therapies for mood disorders: An update. Current Psychiatry Reports. ...

  4. Cortical brain structure and sexual orientation in adult females with bipolar disorder or attention deficit hyperactivity disorder.

    Science.gov (United States)

    Abé, Christoph; Rahman, Qazi; Långström, Niklas; Rydén, Eleonore; Ingvar, Martin; Landén, Mikael

    2018-05-29

    Nonheterosexual individuals have higher risk of psychiatric morbidity. Together with growing evidence for sexual orientation-related brain differences, this raises the concern that sexual orientation may be an important factor to control for in neuroimaging studies of neuropsychiatric disorders. We studied sexual orientation in adult psychiatric patients with bipolar disorder (BD) or ADHD in a large clinical cohort (N = 154). We compared cortical brain structure in exclusively heterosexual women (HEW, n = 29) with that of nonexclusively heterosexual women (nHEW, n = 37) using surface-based reconstruction techniques provided by FreeSurfer. The prevalence of nonheterosexual sexual orientation was tentatively higher than reported in general population samples. Consistent with previously reported cross-sex shifted brain patterns among homosexual individuals, nHEW patients showed significantly larger cortical volumes than HEW in medial occipital brain regions. We found evidence for a sex-reversed difference in cortical volume among nonheterosexual female patients, which provides insights into the neurobiology of sexual orientation, and may provide the first clues toward a better neurobiological understanding of the association between sexual orientation and mental health. We also suggest that sexual orientation is an important factor to consider in future neuroimaging studies of populations with certain mental health disorders. © 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

  5. Field distribution analysis in deflecting structures

    Energy Technology Data Exchange (ETDEWEB)

    Paramonov, V.V. [Joint Inst. for Nuclear Research, Moscow (Russian Federation)

    2013-02-15

    Deflecting structures are used now manly for bunch rotation in emittance exchange concepts, bunch diagnostics and to increase the luminosity. The bunch rotation is a transformation of a particles distribution in the six dimensional phase space. Together with the expected transformations, deflecting structures introduce distortions due to particularities - aberrations - in the deflecting field distribution. The distributions of deflecting fields are considered with respect to non linear additions, which provide emittance deteriorations during a transformation. The deflecting field is treated as combination of hybrid waves HE{sub 1} and HM{sub 1}. The criteria for selection and formation of deflecting structures with minimized level of aberrations are formulated and applied to known structures. Results of the study are confirmed by comparison with results of numerical simulations.

  6. Field distribution analysis in deflecting structures

    International Nuclear Information System (INIS)

    Paramonov, V.V.

    2013-02-01

    Deflecting structures are used now manly for bunch rotation in emittance exchange concepts, bunch diagnostics and to increase the luminosity. The bunch rotation is a transformation of a particles distribution in the six dimensional phase space. Together with the expected transformations, deflecting structures introduce distortions due to particularities - aberrations - in the deflecting field distribution. The distributions of deflecting fields are considered with respect to non linear additions, which provide emittance deteriorations during a transformation. The deflecting field is treated as combination of hybrid waves HE 1 and HM 1 . The criteria for selection and formation of deflecting structures with minimized level of aberrations are formulated and applied to known structures. Results of the study are confirmed by comparison with results of numerical simulations.

  7. Bipolar electrochemistry.

    Science.gov (United States)

    Fosdick, Stephen E; Knust, Kyle N; Scida, Karen; Crooks, Richard M

    2013-09-27

    A bipolar electrode (BPE) is an electrically conductive material that promotes electrochemical reactions at its extremities (poles) even in the absence of a direct ohmic contact. More specifically, when sufficient voltage is applied to an electrolyte solution in which a BPE is immersed, the potential difference between the BPE and the solution drives oxidation and reduction reactions. Because no direct electrical connection is required to activate redox reactions, large arrays of electrodes can be controlled with just a single DC power supply or even a battery. The wireless aspect of BPEs also makes it possible to electrosynthesize and screen novel materials for a wide variety of applications. Finally, bipolar electrochemistry enables mobile electrodes, dubbed microswimmers, that are able to move freely in solution. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Multimodal assessments of the hippocampal formation in schizophrenia and bipolar disorder: Evidences from neurobehavioral measures and functional and structural MRI

    Directory of Open Access Journals (Sweden)

    Christian Knöchel

    2014-01-01

    Full Text Available A potential clinical and etiological overlap between schizophrenia (SZ and bipolar disorder (BD has long been a subject of discussion. Imaging studies imply functional and structural alterations of the hippocampus in both diseases. Thus, imaging this core memory region could provide insight into the pathophysiology of these disorders and the associated cognitive deficits. To examine possible shared alterations in the hippocampus, we conducted a multi-modal assessment, including functional and structural imaging as well as neurobehavioral measures of memory performance in BD and SZ patients compared with healthy controls. We assessed episodic memory performance, using tests of verbal and visual learning (HVLT, BVMT in three groups of participants: BD patients (n = 21, SZ patients (n = 21 and matched (age, gender, education healthy control subjects (n = 21. In addition, we examined hippocampal resting state functional connectivity, hippocampal volume using voxel-based morphometry (VBM and fibre integrity of hippocampal connections using diffusion tensor imaging (DTI. We found memory deficits, changes in functional connectivity within the hippocampal network as well as volumetric reductions and altered white matter fibre integrity across patient groups in comparison with controls. However, SZ patients when directly compared with BD patients were more severely affected in several of the assessed parameters (verbal learning, left hippocampal volumes, mean diffusivity of bilateral cingulum and right uncinated fasciculus. The results of our study suggest a graded expression of verbal learning deficits accompanied by structural alterations within the hippocampus in BD patients and SZ patients, with SZ patients being more strongly affected. Our findings imply that these two disorders may share some common pathophysiological mechanisms. The results could thus help to further advance and integrate current pathophysiological models of SZ and BD.

  9. Structural correlates of creative thinking in patients with bipolar disorder and healthy controls-a voxel-based morphometry study.

    Science.gov (United States)

    Tu, Pei-Chi; Kuan, Yi-Hsuan; Li, Cheng-Ta; Su, Tung-Ping

    2017-06-01

    This study investigated the structural correlates of creative thinking in patients with bipolar disorder (BD) to understand the possible neural mechanism of creative thinking in BD. We recruited 59 patients with BD I or BD II (35.3±8.5 y) and 56 age- and sex-matched controls (HCs; 34±7.4 y). Each participant underwent structural magnetic resonance imaging and evaluation of creative thinking, which was assessed using two validated tools: the Chinese version of the Abbreviated Torrance Test for Adults for divergent thinking and the Chinese Word Remote Associates Test for remote association. Voxel-based morphometry was performed using SPM12. In patients with BD, divergent thinking positively correlated with the gray matter volume (GMV) in right medial frontal gyrus (Brodmann area [BA] 9), and remote association positively correlated with the GMV in the medial prefrontal gyrus (BA 10). In the HCs, divergent thinking negatively correlated with the GMV in left superior frontal gyrus (BA 8) and positively correlated with the GMV in the precuneus and occipital regions, and remote association positively correlated with the GMV in the hippocampus. Patients with BD were receiving various dosages of antipsychotics, antidepressants and mood stabilizer. These medications may confound the GMV-creative thinking relationship in patients with BD. Our findings indicate that medial prefrontal cortex plays a major and positive role in creative thinking in patients with BD. By contrary, creative thinking involves more diverse structures, and the prefrontal cortex may have an opposite effect in HCs. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Alda Martin

    1999-01-01

    Full Text Available Os resultados de estudos de famílias sugerem que o transtorno bipolar tenha uma base genética. Essa hipótese foi reforçada em estudos de adoção e de gêmeos. A herança do transtorno bipolar é complexa, envolve vários genes, além de apresentar heterogeneidade e interação entre fatores genéticos e não-genéticos. Achados, que já foram replicados, já implicaram os cromossomos 4, 12, 18 e 21, entre outros, na busca por genes de suscetibilidade. Os resultados mais promissores foram obtidos através de estudos de ligação. Por outro lado, os estudos de associação geraram dados interessantes, mas ainda vagos. Os estudos de populações de pacientes homogêneos e a melhor definição do fenótipo deverão contribuir para avanços futuros. A identificação dos genes relacionados ao transtorno bipolar irá permitir o melhor entendimento e tratamento dessa doença.

  11. Isolated electrostatic structures observed throughout the Cluster orbit: relationship to magnetic field strength

    Directory of Open Access Journals (Sweden)

    J. S. Pickett

    2004-07-01

    Full Text Available Isolated electrostatic structures are observed throughout much of the 4RE by 19.6RE Cluster orbit. These structures are observed in the Wideband plasma wave instrument's waveform data as bipolar pulses (one positive and one negative peak in the electric field amplitude and tripolar pulses (two positive and one negative peak, or vice versa. These structures are observed at all of the boundary layers, in the solar wind and magnetosheath, and along auroral field lines at 4.5-6.5RE. Using the Wideband waveform data from the various Cluster spacecraft we have carried out a survey of the amplitudes and time durations of these structures and how these quantities vary with the local magnetic field strength. Such a survey has not been carried out before, and it reveals certain characteristics of solitary structures in a finite magnetic field, a topic still inadequately addressed by theories. We find that there is a broad range of electric field amplitudes at any specific magnetic field strength, and there is a general trend for the electric field amplitudes to increase as the strength of the magnetic field increases over a range of 5 to 500nT. We provide a possible explanation for this trend that relates to the structures being Bernstein-Greene-Kruskal mode solitary waves. There is no corresponding dependence of the duration of the structures on the magnetic field strength, although a plot of these two quantities reveals the unexpected result that with the exception of the magnetosheath, all of the time durations for all of the other regions are comparable, whereas the magnetosheath time durations clearly are in a different category of much smaller time duration. We speculate that this implies that the structures are much smaller in size. The distinctly different pulse durations for the magnetosheath pulses indicate the possibility that the pulses are generated by a mechanism which is different from the mechanism operating in other regions.

  12. Gauge field vacuum structure in geometrical aspect

    International Nuclear Information System (INIS)

    Konopleva, N.P.

    2003-01-01

    Vacuum conception is one of the main conceptions of quantum field theory. Its meaning in classical field theory is also very profound. In this case the vacuum conception is closely connected with ideas of the space-time geometry. The global and local geometrical space-time conceptions lead to different vacuum definitions and therefore to different ways of physical theory construction. Some aspects of the gauge field vacuum structure are analyzed. It is shown that in the gauge field theory the vacuum Einstein equation solutions describe the relativistic vacuum as common vacuum of all gauge fields and its sources. Instantons (both usual and hyperbolical) are regarded as nongravitating matter, because they have zero energy-momentum tensors and correspond to vacuum Einstein equations

  13. Jovian cloud structure and velocity fields

    International Nuclear Information System (INIS)

    Mitchell, J.L.; Terrile, R.J.; Collins, S.A.; Smith, B.A.; Muller, J.P.; Ingersoll, A.P.; Hunt, G.E.; Beebe, R.F.

    1979-01-01

    A regional comparison of the cloud structures and velocity fields (meridional as well as zonal velocities) in the jovian atmosphere (scales > 200 km) as observed by the Voyager 1 imaging system is given. It is shown that although both hemispheres of Jupiter show similar patterns of diminishing and alternating eastward and westward jets as one progresses polewards, there is a pronounced asymmetry in the structural appearance of the two hemispheres. (UK)

  14. The Bipolar Field-Effect Transistor: XIII. Physical Realizations of the Transistor and Circuits (One-Two-MOS-Gates on Thin-Thick Pure-Impure Base)

    International Nuclear Information System (INIS)

    Sah, C.-T.; Jie Binbin

    2009-01-01

    This paper reports the physical realization of the Bipolar Field-Effect Transistor (BiFET) and its one-transistor basic building block circuits. Examples are given for the one and two MOS gates on thin and thick, pure and impure base, with electron and hole contacts, and the corresponding theoretical current-voltage characteristics previously computed by us, without generation-recombination-trapping-tunneling of electrons and holes. These examples include the one-MOS-gate on semi-infinite thick impure base transistor (the bulk transistor) and the impurethin-base Silicon-on-Insulator (SOI) transistor and the two-MOS-gates on thin base transistors (the FinFET and the Thin Film Transistor TFT). Figures are given with the cross-section views containing the electron and hole concentration and current density distributions and trajectories and the corresponding DC current-voltage characteristics.

  15. Austerity and geometric structure of field theories

    International Nuclear Information System (INIS)

    Kheyfets, A.

    1986-01-01

    The relation between the austerity idea and the geometric structure of the three basic field theories - electrodynamics, Yang-Mills theory, and general relativity - is studied. One of the most significant manifestations of the austerity idea in field theories is thought to be expressed by the boundary of a boundary principle (BBP). The BBP says that almost all content of the field theories can be deduced from the topological identity of delta dot produced with delta = 0 used twice, at the 1-2-3-dimensional level (providing the homogeneous field equations), and at the 2-3-4-dimensional level (providing the conservation laws for the source currents). There are some difficulties in this line of thought due to the apparent lack of universality in application of the BBP to the three basic modern field theories above. This dissertation: (a) analyzes the difficulties by means of algebraic topology, integration theory, and modern differential geometry based on the concepts of principal bundles and Ehresmann connections: (b) extends the BBP to the unified Kaluza-Klein theory; (c) reformulates the inhomogeneous field equations and the BBP in terms of E. Cartan moment of rotation, in the way universal for the three theories and compatible with the original austerity idea; and (d) underlines the important role of the soldering structure on spacetime, and indicates that the future development of the austerity idea would involve the generalized theories

  16. Static electric field enhancement in nanoscale structures

    Energy Technology Data Exchange (ETDEWEB)

    Lepetit, Bruno, E-mail: bruno.lepetit@irsamc.ups-tlse.fr; Lemoine, Didier, E-mail: didier.lemoine@irsamc.ups-tlse.fr [Université de Toulouse, UPS, Laboratoire Collisions Agrégats Réactivité, IRSAMC, F-31062 Toulouse (France); CNRS, UMR 5589, F-31062 Toulouse (France); Márquez-Mijares, Maykel, E-mail: mmarquez@instec.cu [Université de Toulouse, UPS, Laboratoire Collisions Agrégats Réactivité, IRSAMC, F-31062 Toulouse (France); CNRS, UMR 5589, F-31062 Toulouse (France); Instituto Superior de Tecnologías y Ciencias Aplicadas, Avenida Salvador Allende 1110, Quinta de los Molinos, La Habana (Cuba)

    2016-08-28

    We study the effect of local atomic- and nano-scale protrusions on field emission and, in particular, on the local field enhancement which plays a key role as known from the Fowler-Nordheim model of electronic emission. We study atomic size defects which consist of right angle steps forming an infinite length staircase on a tungsten surface. This structure is embedded in a 1 GV/m ambient electrostatic field. We perform calculations based upon density functional theory in order to characterize the total and induced electronic densities as well as the local electrostatic fields taking into account the detailed atomic structure of the metal. We show how the results must be processed to become comparable with those of a simple homogeneous tungsten sheet electrostatic model. We also describe an innovative procedure to extrapolate our results to nanoscale defects of larger sizes, which relies on the microscopic findings to guide, tune, and improve the homogeneous metal model, thus gaining predictive power. Furthermore, we evidence analytical power laws for the field enhancement characterization. The main physics-wise outcome of this analysis is that limited field enhancement is to be expected from atomic- and nano-scale defects.

  17. The inversion layer of electric fields and electron phase-space-hole structure during two-dimensional collisionless magnetic reconnection

    International Nuclear Information System (INIS)

    Chen Lijen; Lefebvre, Bertrand; Torbert, Roy B.; Daughton, William S.

    2011-01-01

    Based on two-dimensional fully kinetic simulations that resolve the electron diffusion layer in undriven collisionless magnetic reconnection with zero guide field, this paper reports the existence and evolution of an inversion layer of bipolar electric fields, its corresponding phase-space structure (an electron-hole layer), and the implication to collisionless dissipation. The inversion electric field layer is embedded in the layer of bipolar Hall electric field and extends throughout the entire length of the electron diffusion layer. The electron phase-space hole structure spontaneously arises during the explosive growth phase when there exist significant inflows into the reconnection layer, and electrons perform meandering orbits across the layer while being cyclotron-turned toward the outflow directions. The cyclotron turning of meandering electrons by the magnetic field normal to the reconnection layer is shown to be a primary factor limiting the current density in the region where the reconnection electric field is balanced by the gradient (along the current sheet normal) of the off-diagonal electron pressure-tensor.

  18. Integrated neurobiology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Vladimir eMaletic

    2014-08-01

    Full Text Available From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity—reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition—limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional unified field theory of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial-neuronal interactions. Among these glial elements are microglia—the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the HPA axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of bipolarity is one of the great

  19. Particle versus field structure in conformal quantum field theories

    International Nuclear Information System (INIS)

    Schroer, Bert

    2000-06-01

    I show that a particle structure in conformal field theory is incompatible with interactions. As a substitute one has particle-like excitations whose interpolating fields have in addition to their canonical dimension an anomalous contribution. The spectra of anomalous dimension is given in terms of the Lorentz invariant quadratic invariant (compact mass operator) of a conformal generator R μ with pure discrete spectrum. The perturbative reading of R o as a Hamiltonian in its own right, associated with an action in a functional integral setting naturally leads to the Ad S formulation. The formal service role of Ad S in order to access C QFT by a standard perturbative formalism (without being forced to understand first massive theories and then taking their scale-invariant limit) vastly increases the realm of conventionally accessible 4-dim. C QFT beyond those for which one had to use Lagrangians with supersymmetry in order to have a vanishing Beta-function. (author)

  20. Alcoholism and anxiety in bipolar illness : Differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism

    NARCIS (Netherlands)

    Levander, Eric; Frye, Mark A.; McElroy, Susan; Suppes, Trisha; Grunze, Heinz; Nolen, Willem A.; Kupka, Ralph; Keck, Paul E.; Leverich, Gabriele S.; Altshuler, Lori L.; Hwang, Sun; Mintz, Jim; Post, Robert M.

    Introduction: This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD). Methods: Bipolar men and women who entered the Stanley Foundation Bipolar Network (SFBN) underwent a Structured Clinical Interview for

  1. The vector structure of active magnetic fields

    Science.gov (United States)

    Parker, E. N.

    1985-01-01

    Observations are needed to show the form of the strains introduced into the fields above the surface of the Sun. The longitudinal component alone does not provide the basic information, so that it has been necessary in the past to use the filamentary structure observed in H sub alpha to supplement the longitudinal information. Vector measurements provide the additional essential information to determine the strains, with the filamentary structure available as a check for consistency. It is to be expected, then, that vector measurements will permit a direct mapping of the strains imposed on the magnetic fields of active regions. It will be interesting to study the relation of those strains to the emergence of magnetic flux, flares, eruptive prominences, etc. In particular we may hope to study the relaxation of the strains via the dynamical nonequilibrium.

  2. Development of the field of structural physiology

    Science.gov (United States)

    FUJIYOSHI, Yoshinori

    2015-01-01

    Electron crystallography is especially useful for studying the structure and function of membrane proteins — key molecules with important functions in neural and other cells. Electron crystallography is now an established technique for analyzing the structures of membrane proteins in lipid bilayers that closely simulate their natural biological environment. Utilizing cryo-electron microscopes with helium-cooled specimen stages that were developed through a personal motivation to understand the functions of neural systems from a structural point of view, the structures of membrane proteins can be analyzed at a higher than 3 Å resolution. This review covers four objectives. First, I introduce the new research field of structural physiology. Second, I recount some of the struggles involved in developing cryo-electron microscopes. Third, I review the structural and functional analyses of membrane proteins mainly by electron crystallography using cryo-electron microscopes. Finally, I discuss multifunctional channels named “adhennels” based on structures analyzed using electron and X-ray crystallography. PMID:26560835

  3. Magnetic Field Structure in Relativistic Jets

    Directory of Open Access Journals (Sweden)

    Jermak Helen

    2013-12-01

    Full Text Available Relativistic jets are ubiquitous when considering an accreting black hole. Two of the most extreme examples of these systems are blazars and gamma-ray bursts (GRBs, the jets of which are thought to be threaded with a magnetic field of unknown structure. The systems are made up of a black hole accreting matter and producing, as a result, relativistic jets of plasma from the poles of the black hole. Both systems are viewed as point sources from Earth, making it impossible to spatially resolve the jet. In order to explore the structure of the magnetic field within the jet we take polarisation measurements with the RINGO polarimeters on the world’s largest fully autonomous, robotic optical telescope: The Liverpool Telescope. Using the polarisation degree and angle measured by the RINGO polarimeters it is possible to distinguish between global magnetic fields created in the central engine and random tangled magnetic fields produced locally in shocks. We also monitor blazar sources regularly during quiescence with periods of flaring monitored more intensively. Reported here are the early polarisation results for GRBs 060418 and 090102, along with future prospects for the Liverpool Telescope and the RINGO polarimeters.

  4. Integrable structures in quantum field theory

    International Nuclear Information System (INIS)

    Negro, Stefano

    2016-01-01

    This review was born as notes for a lecture given at the Young Researchers Integrability School (YRIS) school on integrability in Durham, in the summer of 2015. It deals with a beautiful method, developed in the mid-nineties by Bazhanov, Lukyanov and Zamolodchikov and, as such, called BLZ. This method can be interpreted as a field theory version of the quantum inverse scattering, also known as the algebraic Bethe ansatz. Starting with the case of conformal field theories (CFTs) we show how to build the field theory analogues of commuting transfer T matrices and Baxter Q -operators of integrable lattice models. These objects contain the complete information of the integrable structure of the theory, viz. the integrals of motion, and can be used, as we will show, to derive the thermodynamic Bethe ansatz and nonlinear integral equations. This same method can be easily extended to the description of integrable structures of certain particular massive deformations of CFTs; these, in turn, can be described as quantum group reductions of the quantum sine-Gordon model and it is an easy step to include this last theory in the framework of BLZ approach. Finally we show an interesting and surprising connection of the BLZ structures with classical objects emerging from the study of classical integrable models via the inverse scattering transform method. This connection goes under the name of ODE/IM correspondence and we will present it for the specific case of quantum sine-Gordon model only. (topical review)

  5. COMPASS magnetic field coils and structure systems

    International Nuclear Information System (INIS)

    Crossland, R.T.; Booth, J.A.; Hayward, R.J.; Keogh, P.; Pratt, A.P.

    1987-01-01

    COMPASS is a new experimental toroidal assembly of compact design and with a wide range of physics objectives. It is required to operate either as a Tokamak or as a Reversed Field Pinch with interchangeable circular and dee-section vacuum vessels. The Toroidal field is produced by 16 rectangular coils of 4 turns with tapered conductors on the inside which nest together to form a vault to resist the centering forces. The coils are designed to produce a maximum field on axis of 2.1T which requires a current of 91 kA per turn. Two central solenoids and five pairs of coils symmetrically positioned above and below the machine equator provide the poloidal field. Both coil systems are supported form a mechanical support structure which surrounds the machine. This is primarily designed to resist out-of-plane forces on the TF coils but also acts as the base support for the PF coils and vacuum vessels. An illustration of the COMPASS Load Assembly is given and shows the D-shaped vacuum vessel, the major components and the various field windings

  6. DeepBipolar: Identifying genomic mutations for bipolar disorder via deep learning.

    Science.gov (United States)

    Laksshman, Sundaram; Bhat, Rajendra Rana; Viswanath, Vivek; Li, Xiaolin

    2017-09-01

    Bipolar disorder, also known as manic depression, is a brain disorder that affects the brain structure of a patient. It results in extreme mood swings, severe states of depression, and overexcitement simultaneously. It is estimated that roughly 3% of the population of the United States (about 5.3 million adults) suffers from bipolar disorder. Recent research efforts like the Twin studies have demonstrated a high heritability factor for the disorder, making genomics a viable alternative for detecting and treating bipolar disorder, in addition to the conventional lengthy and costly postsymptom clinical diagnosis. Motivated by this study, leveraging several emerging deep learning algorithms, we design an end-to-end deep learning architecture (called DeepBipolar) to predict bipolar disorder based on limited genomic data. DeepBipolar adopts the Deep Convolutional Neural Network (DCNN) architecture that automatically extracts features from genotype information to predict the bipolar phenotype. We participated in the Critical Assessment of Genome Interpretation (CAGI) bipolar disorder challenge and DeepBipolar was considered the most successful by the independent assessor. In this work, we thoroughly evaluate the performance of DeepBipolar and analyze the type of signals we believe could have affected the classifier in distinguishing the case samples from the control set. © 2017 Wiley Periodicals, Inc.

  7. Bipolar disorder in adolescence.

    Science.gov (United States)

    DeFilippis, Melissa; Wagner, Karen Dineen

    2013-08-01

    Bipolar disorder is a serious psychiatric condition that may have onset in childhood. It is important for physicians to recognize the symptoms of bipolar disorder in children and adolescents in order to accurately diagnose this illness early in its course. Evidence regarding the efficacy of various treatments is necessary to guide the management of bipolar disorder in youth. For example, several medications commonly used for adults with bipolar disorder have not shown efficacy for children and adolescents with bipolar disorder. This article reviews the prevalence, diagnosis, course, and treatment of bipolar disorder in children and adolescents and provides physicians with information that will aid in diagnosis and treatment.

  8. 2017 Bipolar Plate Workshop Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Kopasz, John P. [Argonne National Lab. (ANL), Argonne, IL (United States); Benjamin, Thomas G. [Argonne National Lab. (ANL), Argonne, IL (United States); Schenck, Deanna [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-08-17

    The Bipolar Plate (BP) Workshop was held at USCAR1 in Southfield, Michigan on February 14, 2017 and included 63 participants from industry, government agencies, universities, and national laboratories with expertise in the relevant fields. The objective of the workshop was to identify research and development (R&D) needs, in particular early-stage R&D, for bipolar plates for polymer electrolyte membrane (PEM) fuel cells for transportation applications. The focus of the workshop was on materials, manufacturing, and design aspects of bipolar plates with the goal of meeting DOE’s 2020 bipolar plate targets. Of special interest was the cost target of ≤$3/kW for the bipolar plate.

  9. Resistive field structures for semiconductor devices and uses therof

    Science.gov (United States)

    Marinella, Matthew; DasGupta, Sandeepan; Kaplar, Robert; Baca, Albert G.

    2017-09-12

    The present disclosure relates to resistive field structures that provide improved electric field profiles when used with a semiconductor device. In particular, the resistive field structures provide a uniform electric field profile, thereby enhancing breakdown voltage and improving reliability. In example, the structure is a field cage that is configured to be resistive, in which the potential changes significantly over the distance of the cage. In another example, the structure is a resistive field plate. Using these resistive field structures, the characteristics of the electric field profile can be independently modulated from the physical parameters of the semiconductor device. Additional methods and architectures are described herein.

  10. Structural alloys for high field superconducting magnets

    International Nuclear Information System (INIS)

    Morris, J.W. Jr.

    1985-08-01

    Research toward structural alloys for use in high field superconducting magnets is international in scope, and has three principal objectives: the selection or development of suitable structural alloys for the magnet support structure, the identification of mechanical phenomena and failure modes that may influence service behavior, and the design of suitable testing procedures to provide engineering design data. This paper reviews recent progress toward the first two of these objectives. The structural alloy needs depend on the magnet design and superconductor type and differ between magnets that use monolithic and those that employ force-cooled or ICCS conductors. In the former case the central requirement is for high strength, high toughness, weldable alloys that are used in thick sections for the magnet case. In the latter case the need is for high strength, high toughness alloys that are used in thin welded sections for the conductor conduit. There is productive current research on both alloy types. The service behavior of these alloys is influenced by mechanical phenomena that are peculiar to the magnet environment, including cryogenic fatigue, magnetic effects, and cryogenic creep. The design of appropriate mechanical tests is complicated by the need for testing at 4 0 K and by rate effects associated with adiabatic heating during the tests. 46 refs

  11. Genetics of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Kerner B

    2014-02-01

    Full Text Available Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a “risk” allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are

  12. Bipolar disorder diagnosis: challenges and future directions

    Science.gov (United States)

    Phillips, Mary L; Kupfer, David J

    2018-01-01

    Bipolar disorder refers to a group of affective disorders, which together are characterised by depressive and manic or hypomanic episodes. These disorders include: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and hypomanic episodes); cyclothymic disorder (hypomanic and depressive symptoms that do not meet criteria for depressive episodes); and bipolar disorder not otherwise specified (depressive and hypomanic-like symptoms that do not meet the diagnostic criteria for any of the aforementioned disorders). Bipolar disorder type II is especially difficult to diagnose accurately because of the difficulty in differentiation of this disorder from recurrent unipolar depression (recurrent depressive episodes) in depressed patients. The identification of objective biomarkers that represent pathophysiologic processes that differ between bipolar disorder and unipolar depression can both inform bipolar disorder diagnosis and provide biological targets for the development of new and personalised treatments. Neuroimaging studies could help the identification of biomarkers that differentiate bipolar disorder from unipolar depression, but the problem in detection of a clear boundary between these disorders suggests that they might be better represented as a continuum of affective disorders. Innovative combinations of neuroimaging and pattern recognition approaches can identify individual patterns of neural structure and function that accurately ascertain where a patient might lie on a behavioural scale. Ultimately, an integrative approach, with several biological measurements using different scales, could yield patterns of biomarkers (biosignatures) to help identify biological targets for personalised and new treatments for all affective disorders. PMID:23663952

  13. Cytokines in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Vedel Kessing, Lars

    2012-01-01

    BACKGROUND: Current research and hypothesis regarding the pathophysiology of bipolar disorder suggests the involvement of immune system dysfunction that is possibly related to disease activity. Our objective was to systematically review evidence of cytokine alterations in bipolar disorder according...... to affective state. METHODS: We conducted a systemtic review of studies measuring endogenous cytokine concentrations in patients with bipolar disorder and a meta-analysis, reporting results according to the PRISMA statement. RESULTS: Thirteen studies were included, comprising 556 bipolar disorder patients...

  14. Abnormal functional-structural cingulum connectivity in mania: combined functional magnetic resonance imaging-diffusion tensor imaging investigation in different phases of bipolar disorder.

    Science.gov (United States)

    Martino, M; Magioncalda, P; Saiote, C; Conio, B; Escelsior, A; Rocchi, G; Piaggio, N; Marozzi, V; Huang, Z; Ferri, F; Amore, M; Inglese, M; Northoff, G

    2016-10-01

    The objective of the study was to investigate the relationship between structural connectivity (SC) and functional connectivity (FC) in the cingulum in bipolar disorder (BD) and its various phases. We combined resting-state functional magnetic resonance imaging and probabilistic tractographic diffusion tensor imaging to investigate FC and SC of the cingulum and its portions, the SC-FC relationship, and their correlations with clinical and neurocognitive measures on sustained attention in manic (n = 21), depressed (n = 20), and euthymic (n = 20) bipolar patients and healthy controls (HC) (n = 42). First, we found decreased FC between the anterior and posterior parts of the cingulum in manic patients when compared to depressed patients and HC. Second, we observed decreased SC of the cingulum bundle, particularly in its anterior part, in manic patients when compared to HC. Finally, alterations in the cingulum FC (but not SC) correlated with clinical severity scores while changes in the cingulum SC (but not FC) were related with neurocognitive deficits in sustained attention in BD. We demonstrate for the first time a reduction in FC and concomitantly in SC of the cingulum in mania, which correlated with psychopathological and neurocognitive parameters, respectively, in BD. This supports the central role of cingulum connectivity specifically in mania. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Method of using triaxial magnetic fields for making particle structures

    Science.gov (United States)

    Martin, James E.; Anderson, Robert A.; Williamson, Rodney L.

    2005-01-18

    A method of producing three-dimensional particle structures with enhanced magnetic susceptibility in three dimensions by applying a triaxial energetic field to a magnetic particle suspension and subsequently stabilizing said particle structure. Combinations of direct current and alternating current fields in three dimensions produce particle gel structures, honeycomb structures, and foam-like structures.

  16. Nutrition and Bipolar Depression.

    Science.gov (United States)

    Beyer, John L; Payne, Martha E

    2016-03-01

    As with physical conditions, bipolar disorder is likely to be impacted by diet and nutrition. Patients with bipolar disorder have been noted to have relatively unhealthy diets, which may in part be the reason they also have an elevated risk of metabolic syndrome and obesity. An improvement in the quality of the diet should improve a bipolar patient's overall health risk profile, but it may also improve their psychiatric outcomes. New insights into biological dysfunctions that may be present in bipolar disorder have presented new theoretic frameworks for understanding the relationship between diet and bipolar disorder. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Isolated electrostatic structures observed throughout the Cluster orbit: relationship to magnetic field strength

    Directory of Open Access Journals (Sweden)

    J. S. Pickett

    2004-07-01

    Full Text Available Isolated electrostatic structures are observed throughout much of the 4RE by 19.6RE Cluster orbit. These structures are observed in the Wideband plasma wave instrument's waveform data as bipolar pulses (one positive and one negative peak in the electric field amplitude and tripolar pulses (two positive and one negative peak, or vice versa. These structures are observed at all of the boundary layers, in the solar wind and magnetosheath, and along auroral field lines at 4.5-6.5RE. Using the Wideband waveform data from the various Cluster spacecraft we have carried out a survey of the amplitudes and time durations of these structures and how these quantities vary with the local magnetic field strength. Such a survey has not been carried out before, and it reveals certain characteristics of solitary structures in a finite magnetic field, a topic still inadequately addressed by theories. We find that there is a broad range of electric field amplitudes at any specific magnetic field strength, and there is a general trend for the electric field amplitudes to increase as the strength of the magnetic field increases over a range of 5 to 500nT. We provide a possible explanation for this trend that relates to the structures being Bernstein-Greene-Kruskal mode solitary waves. There is no corresponding dependence of the duration of the structures on the magnetic field strength, although a plot of these two quantities reveals the unexpected result that with the exception of the magnetosheath, all of the time durations for all of the other regions are comparable, whereas the magnetosheath time durations clearly are in a different category of much smaller time duration. We speculate that this implies that the structures are much smaller in size. The distinctly different pulse durations for the magnetosheath pulses indicate the possibility that the pulses are generated by a mechanism which is different

  18. High-performance silicon nanowire bipolar phototransistors

    Science.gov (United States)

    Tan, Siew Li; Zhao, Xingyan; Chen, Kaixiang; Crozier, Kenneth B.; Dan, Yaping

    2016-07-01

    Silicon nanowires (SiNWs) have emerged as sensitive absorbing materials for photodetection at wavelengths ranging from ultraviolet (UV) to the near infrared. Most of the reports on SiNW photodetectors are based on photoconductor, photodiode, or field-effect transistor device structures. These SiNW devices each have their own advantages and trade-offs in optical gain, response time, operating voltage, and dark current noise. Here, we report on the experimental realization of single SiNW bipolar phototransistors on silicon-on-insulator substrates. Our SiNW devices are based on bipolar transistor structures with an optically injected base region and are fabricated using CMOS-compatible processes. The experimentally measured optoelectronic characteristics of the SiNW phototransistors are in good agreement with simulation results. The SiNW phototransistors exhibit significantly enhanced response to UV and visible light, compared with typical Si p-i-n photodiodes. The near infrared responsivities of the SiNW phototransistors are comparable to those of Si avalanche photodiodes but are achieved at much lower operating voltages. Compared with other reported SiNW photodetectors as well as conventional bulk Si photodiodes and phototransistors, the SiNW phototransistors in this work demonstrate the combined advantages of high gain, high photoresponse, low dark current, and low operating voltage.

  19. Excellent selector performance in engineered Ag/ZrO2:Ag/Pt structure for high-density bipolar RRAM applications

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2017-12-01

    Full Text Available A high-performance selector with bidirectional threshold switching (TS characteristics of Ag/ZrO2/Pt structure was prepared by incorporating metallic Ag into the ZrO2 matrix. The bidirectional TS device exhibited excellent switching uniformity, forming-free behavior, ultra-low off current of <1 nA and adjustable selectivity (from 102 to 107. The experiment results confirmed that metallic Ag clusters were penetrated into the ZrO2 matrix during the annealing process, which would function as an effective active source responsible for the bidirectional TS. The volatile behavior could be explained by the self-dissolution of unstable filaments caused by minimization of the interfacial energy and thermal effect. Furthermore, a bipolar-type one selector-one resistor (1S-1R memory device was successfully fabricated and exhibited significant suppression of the undesired sneak current, indicating the great potential as selector in a cross-point array.

  20. Excellent selector performance in engineered Ag/ZrO2:Ag/Pt structure for high-density bipolar RRAM applications

    Science.gov (United States)

    Wang, Chao; Song, Bing; Zeng, Zhongming

    2017-12-01

    A high-performance selector with bidirectional threshold switching (TS) characteristics of Ag/ZrO2/Pt structure was prepared by incorporating metallic Ag into the ZrO2 matrix. The bidirectional TS device exhibited excellent switching uniformity, forming-free behavior, ultra-low off current of selectivity (from 102 to 107). The experiment results confirmed that metallic Ag clusters were penetrated into the ZrO2 matrix during the annealing process, which would function as an effective active source responsible for the bidirectional TS. The volatile behavior could be explained by the self-dissolution of unstable filaments caused by minimization of the interfacial energy and thermal effect. Furthermore, a bipolar-type one selector-one resistor (1S-1R) memory device was successfully fabricated and exhibited significant suppression of the undesired sneak current, indicating the great potential as selector in a cross-point array.

  1. Integrated Neurobiology of Bipolar Disorder

    Science.gov (United States)

    Maletic, Vladimir; Raison, Charles

    2014-01-01

    From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity – reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition – limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional “unified field theory” of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial–neuronal interactions. Among these glial elements are microglia – the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the hypothalamic–pituitary–adrenal axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway, or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of

  2. Bipolar soft connected, bipolar soft disconnected and bipolar soft compact spaces

    Directory of Open Access Journals (Sweden)

    Muhammad Shabir

    2017-06-01

    Full Text Available Bipolar soft topological spaces are mathematical expressions to estimate interpretation of data frameworks. Bipolar soft theory considers the core features of data granules. Bipolarity is important to distinguish between positive information which is guaranteed to be possible and negative information which is forbidden or surely false. Connectedness and compactness are the most important fundamental topological properties. These properties highlight the main features of topological spaces and distinguish one topology from another. Taking this into account, we explore the bipolar soft connectedness, bipolar soft disconnectedness and bipolar soft compactness properties for bipolar soft topological spaces. Moreover, we introduce the notion of bipolar soft disjoint sets, bipolar soft separation, and bipolar soft hereditary property and study on bipolar soft connected and disconnected spaces. By giving the detailed picture of bipolar soft connected and disconnected spaces we investigate bipolar soft compact spaces and derive some results related to this concept.

  3. Vacuum magnetic field structure of compact torii

    International Nuclear Information System (INIS)

    Sobehart, J.R.

    1990-01-01

    A new class of axisymmetric vacuum field solutions of the Grad--Shafranov equation, which is suitable for describing the field external to a compact torus equilibrium, is presented. In particular, solutions that match straight field lines at infinity are studied

  4. The thermodynamics of bipolarity: a bifurcation model of bipolar illness and bipolar character and its psychotherapeutic applications.

    Science.gov (United States)

    Sabelli, H C; Carlson-Sabelli, L; Javaid, J I

    1990-11-01

    Two models dominate current formulations of bipolar illness: the homeostatic model implicit in Freud's psychodynamics and most neuroamine deficit/excess theories; and the oscillatory model of exaggerated biological rhythms. The homeostatic model is based on the closed systems approach of classic thermodynamics, while the oscillatory model requires the open systems approach of modern thermodynamics. Here we present a thermodynamic model of bipolarity that includes both homeostatic and oscillatory features and adds the most important feature of open systems thermodynamics: the creation of novel structures in bifurcation processes. According to the proposed model, bipolarity is the result of exaggerated biological energy that augments homeostatic, oscillatory and creative psychological processes. Only low-energy closed systems tend to rest ("point attractor") and entropic disorder. Open processes containing and exchanging energy fluctuate between opposite states ("periodic attractors"); they are characteristic of most physiological rhythms and are exaggerated in bipolar subjects. At higher energies, their strong fluctuations destroy pre-existing patterns and structures, produce turbulence ("chaotic attractors"), which sudden switches between opposite states, and create new and more complex structures. Likewise, high-energy bipolars develop high spontaneity, great fluctuations between opposite moods, internal and interpersonal chaos, and enhanced creativity (personal, artistic, professional) as well as psychopathology (personality deviations, psychotic delusions). Offered here is a theoretical explanation of the dual--creative and destructive--nature of bipolarity in terms of the new enantiodromic concept of entropy generalized by process theory. Clinically, this article offers an integrative model of bipolarity that accounts for many clinical features and contributes to a definition of the bipolar personality.

  5. Genetics Home Reference: bipolar disorder

    Science.gov (United States)

    ... Email Facebook Twitter Home Health Conditions Bipolar disorder Bipolar disorder Printable PDF Open All Close All Enable Javascript to view the expand/collapse boxes. Description Bipolar disorder is a mental health condition that causes extreme ...

  6. BIPOLAR DISORDER: A REVIEW

    OpenAIRE

    Pathan Dilnawaz N; Ziyaurrahaman A.R; Bhise K.S.

    2010-01-01

    Bipolar disorder (BD) is a severe psychiatric disorder that results in poor global functioning, reduced quality of life and high relapse rates. Research finds that many adults with bipolar disorder identify the onset of symptoms in childhood and adolescence, indicating the importance of early accurate diagnosis and treatment. Accurate diagnosis of mood disorders is critical for treatment to be effective. Distinguishing between major depression and bipolar disorders, especially the depressed p...

  7. Molecular structure and motion in zero field magnetic resonance

    International Nuclear Information System (INIS)

    Jarvie, T.P.

    1989-10-01

    Zero field magnetic resonance is well suited for the determination of molecular structure and the study of motion in disordered materials. Experiments performed in zero applied magnetic field avoid the anisotropic broadening in high field nuclear magnetic resonance (NMR) experiments. As a result, molecular structure and subtle effects of motion are more readily observed

  8. Bipolar Disorder in Women

    Directory of Open Access Journals (Sweden)

    Sermin Kesebir

    2013-06-01

    Full Text Available The research on gender's role in bipolar disorders has drawn significant interest recently. The presentation and course of bipolar disorder differs between women and men. Women experience depressive episodes, dysphoric mood, mixed states, rapid cycling and seasonal patterns more often than men. Comorbidity, particularly thyroid disease, migraine, obesity, and anxiety disorders laso occur more frequently in women than men. On the other hand men with bipolar disorder are also more likely than women to have problems with drug or alcohol abuse. The pregnancy and postpartum period is a time of high risk for onset and recurrence of bipolar disorder in women.

  9. Bipolar electrochemistry: from materials science to motion and beyond.

    Science.gov (United States)

    Loget, Gabriel; Zigah, Dodzi; Bouffier, Laurent; Sojic, Neso; Kuhn, Alexander

    2013-11-19

    Bipolar electrochemistry, a phenomenon which generates an asymmetric reactivity on the surface of conductive objects in a wireless manner, is an important concept for many purposes, from analysis to materials science as well as for the generation of motion. Chemists have known the basic concept for a long time, but it has recently attracted additional attention, especially in the context of micro- and nanoscience. In this Account, we introduce the fundamentals of bipolar electrochemistry and illustrate its recent applications, with a particular focus on the fields of materials science and dynamic systems. Janus particles, named after the Roman god depicted with two faces, are currently in the heart of many original investigations. These objects exhibit different physicochemical properties on two opposite sides. This makes them a unique class of materials, showing interesting features. They have received increasing attention from the materials science community, since they can be used for a large variety of applications, ranging from sensing to photosplitting of water. So far the great majority of methods developed for the generation of Janus particles breaks the symmetry by using interfaces or surfaces. The consequence is often a low time-space yield, which limits their large scale production. In this context, chemists have successfully used bipolar electrodeposition to break the symmetry. This provides a single-step technique for the bulk production of Janus particles with a high control over the deposit structure and morphology, as well as a significantly improved yield. In this context, researchers have used the bipolar electrodeposition of molecular layers, metals, semiconductors, and insulators at one or both reactive poles of bipolar electrodes to generate a wide range of Janus particles with different size, composition and shape. In using bipolar electrochemistry as a driving force for generating motion, its intrinsic asymmetric reactivity is again the

  10. Conformal transformation and symplectic structure of self-dual fields

    International Nuclear Information System (INIS)

    Yang Kongqing; Luo Yan

    1996-01-01

    Considered two dimensional self-dual fields, the symplectic structure on the space of solutions is given. It is shown that this structure is Poincare invariant. The Lagrangian of two dimensional self-dual field is invariant under infinite one component conformal group, then this symplectic structure is also invariant under this conformal group. The conserved currents in geometrical formalism are also obtained

  11. Suicide attempts and clinical features of bipolar patients

    OpenAIRE

    Berkol, Tongu? D.; ?slam, Serkan; K?rl?, Ebru; P?narba??, Rasim; ?zy?ld?r?m, ?lker

    2016-01-01

    Objectives: To identify clinical predictors of suicide attempts in patients with bipolar disorder. Methods: This study included bipolar patients who were treated in the Psychiatry Department, Haseki Training and Research Hospital, Istanbul, Turkey, between 2013 and 2014; an informed consent was obtained from the participants. Two hundred and eighteen bipolar patients were assessed by using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition...

  12. Preparation of bipolar membranes by electrospinning

    International Nuclear Information System (INIS)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen

    2017-01-01

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  13. Preparation of bipolar membranes by electrospinning

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen, E-mail: twxu@ustc.edu.cn

    2017-01-15

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  14. Mean field approach to nuclear structure

    International Nuclear Information System (INIS)

    Nazarewicz, W.; Tennessee Univ., Knoxville, TN

    1993-01-01

    Several examples of mean-field calculations, relevant to the recent and planned low-spin experimental works, are presented. The perspectives for future studies (mainly related to spectroscopy of exotic nuclei) are reviewd

  15. Enhanced low dose rate radiation effect test on typical bipolar devices

    International Nuclear Information System (INIS)

    Liu Minbo; Chen Wei; Yao Zhibin; He Baoping; Huang Shaoyan; Sheng Jiangkun; Xiao Zhigang; Wang Zujun

    2014-01-01

    Two types of bipolar transistors and nine types bipolar integrated circuit were selected in the irradiation experiment at different "6"0Co γ dose rate. The base current of bipolar transistor and input bias current of amplifier and comparator was measured, low dose enhance factor of test device was obtained. The results show that bipolar device have enhanced low dose rate sensitivity, enhancement factor of bipolar integrated circuit was bigger than that of transistor, and enhanced low dose rate sensitivity greatly varied with different structure and process of bipolar device. (authors)

  16. Comorbidity bipolar disorder and personality disorders.

    Science.gov (United States)

    Latalova, Klara; Prasko, Jan; Kamaradova, Dana; Sedlackova, Jana; Ociskova, Marie

    2013-01-01

    Outcome in bipolar patients can be affected by comorbidity of other psychiatric disorders. Comorbid personality disorders are frequent and may complicate the course of bipolar illness. We have much information about treating patients with uncomplicated bipolar disorder (BD) but much less knowledge about possibilities for patients with the comorbidity of BD and personality disorder. We conducted a series of literature searches using, as key words or as items in indexed fields, bipolar disorder and personality disorder or personality traits. Articles were obtained by searching MEDLINE from 1970 to 2012. In addition, we used other papers cited in articles from these searches, or cited in articles used in our own work. Tests of personality traits indicated that euthymic bipolar patients have higher scores on harm avoidance, reward dependence, and novelty seeking than controls. Elevation of novelty seeking in bipolar patients is associated with substance abuse comorbidity. Comorbidity with personality disorders in BD patients is associated with a more difficult course of illness (such as longer episodes, shorter time euthymic, and earlier age at onset) and an increase in comorbid substance abuse, suicidality and aggression. These problems are particularly pronounced in comorbidity with borderline personality disorder. Comorbidity with antisocial personality disorder elicits a similar spectrum of difficulties; some of the antisocial behavior exhibited by patients with this comorbidity is mediated by increased impulsivity.

  17. [Circadian markers and genes in bipolar disorder].

    Science.gov (United States)

    Yeim, S; Boudebesse, C; Etain, B; Belliviera, F

    2015-09-01

    Bipolar disorder is a severe and complex multifactorial disease, characterized by alternance of acute episodes of depression and mania/hypomania, interspaced by euthymic periods. The etiological determinants of bipolar disorder yet, are still poorly understood. For the last 30 years, chronobiology is an important field of investigation to better understand the pathophysiology of bipolar disorder. We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms. The search critera was presence of word in any field of the article. Quantitative and qualitative circadian abnormalities are associated with bipolar disorders both during acute episodes and euthymic periods, suggesting that these altered circadian rhythms may represent biological trait markers of the disorder. These circadian dysfunctions were assessed by various validated tools including polysomnography, actigraphy, sleep diaries, chronotype assessments and blood melatonin/cortisol measures. Other altered endogenous circadian activities have also been reported in bipolar patients, such as hormones secretion, core body temperature or fibroblasts activity. Moreover, these markers were also altered in healthy relatives of bipolar patients, suggesting a degree of heritability. Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε. Thus, these circadian gene variants may contribute to the genetic susceptibility of the disease. Furthermore, the study of the clock system may help to better understand some phenotypic aspects like the

  18. Structural design of the superconducting toroidal field coils for ITER

    International Nuclear Information System (INIS)

    Wong, F.M.G.; Sborchia, C.; Thome, R.J.; Malkov, A.; Titus, P.H.

    1995-01-01

    Structural design issues and features of the superconducting toroidal field (TF) coils for the International Thermonuclear Experimental Reactor (ITER) will be discussed. Selected analyses of the structural and mechanical behavior of the ITER TF coils will also be presented. (orig.)

  19. Comparative familial aggregation of bipolar disorder in patients with bipolar I and bipolar II disorders.

    Science.gov (United States)

    Parker, Gordon B; Romano, Mia; Graham, Rebecca K; Ricciardi, Tahlia

    2018-05-01

    We sought to quantify the prevalence and differential prevalence of a bipolar disorder among family members of patients with a bipolar I or II disorder. The sample comprised 1165 bipolar and 1041 unipolar patients, with the former then sub-typed as having either a bipolar I or II condition. Family history data was obtained via an online self-report tool. Prevalence of a family member having a bipolar disorder (of either sub-type) was distinctive (36.8%). Patients with a bipolar I disorder reported a slightly higher family history (41.2%) compared to patients with a bipolar II disorder (36.3%), and with both significantly higher than the rate of bipolar disorder in family members of unipolar depressed patients (18.5%). Findings support the view that bipolar disorder is heritable. The comparable rates in the two bipolar sub-types support the positioning of bipolar II disorder as a valid condition with strong genetic underpinnings.

  20. The impact of the CACNA1C risk allele on limbic structures and facial emotions recognition in bipolar disorder subjects and healthy controls.

    Science.gov (United States)

    Soeiro-de-Souza, Márcio Gerhardt; Otaduy, Maria Concepción Garcia; Dias, Carolina Zadres; Bio, Danielle S; Machado-Vieira, Rodrigo; Moreno, Ricardo Alberto

    2012-12-01

    Impairments in facial emotion recognition (FER) have been reported in bipolar disorder (BD) during all mood states. FER has been the focus of functional magnetic resonance imaging studies evaluating differential activation of limbic regions. Recently, the α1-C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene has been described as a risk gene for BD and its Met allele found to increase CACNA1C mRNA expression. In healthy controls, the CACNA1C risk (Met) allele has been reported to increase limbic system activation during emotional stimuli and also to impact on cognitive function. The aim of this study was to investigate the impact of CACNA1C genotype on FER scores and limbic system morphology in subjects with BD and healthy controls. Thirty-nine euthymic BD I subjects and 40 healthy controls were submitted to a FER recognition test battery and genotyped for CACNA1C. Subjects were also examined with a 3D 3-Tesla structural imaging protocol. The CACNA1C risk allele for BD was associated to FER impairment in BD, while in controls nothing was observed. The CACNA1C genotype did not impact on amygdala or hippocampus volume neither in BD nor controls. Sample size. The present findings suggest that a polymorphism in calcium channels interferes FER phenotype exclusively in BD and doesn't interfere on limbic structures morphology. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. Structure provided by parents in middle childhood predicts cortisol reactivity in adolescence among the offspring of parents with bipolar disorder and controls.

    Science.gov (United States)

    Ellenbogen, Mark A; Hodgins, Sheilagh

    2009-06-01

    Recent studies suggest that childhood exposure to adversity influences later functioning of the hypothalamic-pituitary-adrenal (HPA) axis. Parenting style in childhood, a putative moderator of adversity, may be important in determining HPA reactivity in adolescence. As part of a prospective, longitudinal study, saliva was collected at awakening and 30 and 60 min later over 2 days among 27 offspring of parents with bipolar disorder (high risk; 16.7+/-1.5 years) and 26 offspring of parents with no mental disorders (low risk; 16.2+/-1.7 years). In addition, 24 of the high risk and 22 of the low risk adolescents completed the "Trier Social Stress Test" (TSST). Parents had rated their parenting style when their offspring were 6-13 years of age. Low levels of structure (i.e. organization and consistency) provided by parents in middle childhood were predictive of an elevated cortisol response following awakening (beta=-0.36; padolescents' mood and behavior. The level of structure provided by parents in childhood predicted independent measures of cortisol reactivity in adolescence, suggesting that parenting style may regulate different aspects of HPA reactivity.

  2. Meaning Structures in a Contested Issue Field

    DEFF Research Database (Denmark)

    Meyer, Renate; Höllerer, Markus

    2010-01-01

    When organizational concepts spread beyond national and cultural boundaries, they must pass through powerful filters of local cultural and structural opportunities and constraints in order to mobilize legitimacy. Struggles over their meaning are intensified if they challenge the prevailing order...

  3. Bipolar magnetic semiconductor in silicene nanoribbons

    International Nuclear Information System (INIS)

    Farghadan, Rouhollah

    2017-01-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  4. Bipolar magnetic semiconductor in silicene nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Farghadan, Rouhollah, E-mail: rfarghadan@kashanu.ac.ir

    2017-08-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  5. Structure of magnetic field in Tokamaks

    International Nuclear Information System (INIS)

    Heller, M.V.A.P.; Caldas, I.L.

    1990-01-01

    Magnetic surfaces, necessary to plasma confinement, can be extinguished by resonant helical perturbations with small intensities due to plasma oscillations or external helical currents. The mapping of magnetic field is obtained intergrating numerically the differential equation of its lines. Criteria which evaluate the chaotic distribution of lines between resonant magnetic islands are presented. (M.C.K.) [pt

  6. Classification of cognitive performance in bipolar disorder.

    Science.gov (United States)

    Sparding, Timea; Silander, Katja; Pålsson, Erik; Östlind, Josefin; Ekman, Carl Johan; Sellgren, Carl M; Joas, Erik; Hansen, Stefan; Landén, Mikael

    2017-09-01

    To understand the etiology of cognitive impairment associated with bipolar disorder, we need to clarify potential heterogeneity in cognitive functioning. To this end, we used multivariate techniques to study if the correlation structure of cognitive abilities differs between persons with bipolar disorder and controls. Clinically stable patients with bipolar disorder (type I: n = 64; type II: n = 44) and healthy controls (n = 86) were assessed with a wide range of cognitive tests measuring executive function, speed, memory, and verbal skills. Data were analysed with multivariate techniques. A distinct subgroup (∼30%) could be identified that performed significantly poorer on tests concerning memory function. This cognitive phenotype subgroup did not differ from the majority of bipolar disorder patients with respect to other demographic or clinical characteristics. Whereas the majority of patients performed similar to controls, a subgroup of patients with bipolar disorder differed substantially from healthy controls in the correlation pattern of low-level cognitive abilities. This suggests that cognitive impairment is not a general trait in bipolar disorder but characteristic of a cognitive subgroup. This has important clinical implications for cognitive rehabilitation and remediation.

  7. "Is it menopause or bipolar?": a qualitative study of the experience of menopause for women with bipolar disorder.

    Science.gov (United States)

    Perich, Tania; Ussher, Jane; Parton, Chloe

    2017-11-16

    Menopause can be a time of change for women and may be marked by disturbances in mood. For women living with a mental illness, such as bipolar disorder, little is known about how they experience mood changes during menopause. This study aimed to explore how women with bipolar disorder constructed mood changes during menopause and how this impacted on treatment decisions. Semi-structured interviews were undertaken with fifteen women who reported they had been diagnosed with bipolar disorder. Data was analysed using thematic analysis guided by a social constructionist framework. Themes identified included 'Constructions of mood change: menopause or bipolar disorder?',' Life events, bipolar disorder and menopause coming together'; 'Treatment choices for mood change during menopause'. The accounts suggested that women related to the experience of mood changes during menopause through the lens of their existing framework of bipolar disorder, with implications for understanding of self and treatment choices.

  8. Properties of Bipolar Fuzzy Hypergraphs

    OpenAIRE

    Akram, M.; Dudek, W. A.; Sarwar, S.

    2013-01-01

    In this article, we apply the concept of bipolar fuzzy sets to hypergraphs and investigate some properties of bipolar fuzzy hypergraphs. We introduce the notion of $A-$ tempered bipolar fuzzy hypergraphs and present some of their properties. We also present application examples of bipolar fuzzy hypergraphs.

  9. Effects of the magnetic field on the structure of materials

    International Nuclear Information System (INIS)

    Nakajima, Tetsuo

    1984-02-01

    This is a report of the ''Meeting on the effects of a magnetic field on the structure of materials'' held at KEK, Japan. The purpose of the Meeting was to study the diffraction of SR X-ray in a magnetic field. It was found that the effects of a magnetic field have been seen in various substnaces. The effects are due to the Zeeman effect, the Lamor diamagnetism, the Landau diamagnetism, the Meissner effect and the polarization effect. The topics discussed at the Meeting were the structure study of biological specimens by field orientation, the study of cell structure by field orientation, the phase transition under a strong pulse field, the behavior of high molecular liquid crystal in a magnetic field, the change of the f-electron density of the Tb 3+ ions in Tb IG in a magnetic field at low temperature, an electromagnet loaded on a goniometer and an in-situ observation system for the structure of magnetic domain, the control of structural phase transition by a magnetic field, the use of synchrotron orbit radiation for the structural analysis of random systems, and the field effect on chemical reactions. (Kato, T.)

  10. Influence of magnetic fields on structural martensitic transitions

    Energy Technology Data Exchange (ETDEWEB)

    Lashley, J C [Los Alamos National Laboratory; Cooley, J C [Los Alamos National Laboratory; Smith, J L [Los Alamos National Laboratory; Fisher, R A [NON LANL; Modic, K A [Los Alamos National Laboratory; Yang, X- D [TEMPLE UNIV; Riseborough, P S [TEMPLE UNIV.; Opeil, C P [BOSTON COLLEGE; Finlayson, T R [UNIV OF MELBOURNE; Goddard, P A [UNIV OF OXFORD; Silhanek, A V [INPAC

    2009-01-01

    We show evidence that a structural martensitic transition is related to significant changes in the electronic structure, as revealed in thermodynamic measurements made in high-magnetic fields. The magnetic field dependence is considered unusual as many influential investigations of martensitic transitions have emphasized that the structural transitions are primarily lattice dynamical and are driven by the entropy due to the phonons. We provide a theoretical framework which can be used to describe the effect of magnetic field on the lattice dynamics in which the field dependence originates from the dielectric constant.

  11. Hamiltonian structure of gravitational field theory

    International Nuclear Information System (INIS)

    Rayski, J.

    1992-01-01

    Hamiltonian generalizations of Einstein's theory of gravitation introducing a laminar structure of spacetime are discussed. The concepts of general relativity and of quasi-inertial coordinate systems are extended beyond their traditional scope. Not only the metric, but also the coordinate system, if quantized, undergoes quantum fluctuations

  12. Bipolar Disorder in Children

    Science.gov (United States)

    2014-01-01

    Although bipolar disorder historically was thought to only occur rarely in children and adolescents, there has been a significant increase in children and adolescents who are receiving this diagnosis more recently (Carlson, 2005). Nonetheless, the applicability of the current bipolar disorder diagnostic criteria for children, particularly preschool children, remains unclear, even though much work has been focused on this area. As a result, more work needs to be done to further the understanding of bipolar symptoms in children. It is hoped that this paper can assist psychologists and other health service providers in gleaning a snapshot of the literature in this area so that they can gain an understanding of the diagnostic criteria and other behaviors that may be relevant and be informed about potential approaches for assessment and treatment with children who meet bipolar disorder criteria. First, the history of bipolar symptoms and current diagnostic criteria will be discussed. Next, assessment strategies that may prove helpful for identifying bipolar disorder will be discussed. Then, treatments that may have relevance to children and their families will be discussed. Finally, conclusions regarding work with children who may have a bipolar disorder diagnosis will be offered. PMID:24800202

  13. Functional connectivity and neuronal variability of resting state activity in bipolar disorder--reduction and decoupling in anterior cortical midline structures.

    Science.gov (United States)

    Magioncalda, Paola; Martino, Matteo; Conio, Benedetta; Escelsior, Andrea; Piaggio, Niccolò; Presta, Andrea; Marozzi, Valentina; Rocchi, Giulio; Anastasio, Loris; Vassallo, Linda; Ferri, Francesca; Huang, Zirui; Roccatagliata, Luca; Pardini, Matteo; Northoff, Georg; Amore, Mario

    2015-02-01

    The cortical midline structures seem to be involved in the modulation of different resting state networks, such as the default mode network (DMN) and salience network (SN). Alterations in these systems, in particular in the perigenual anterior cingulate cortex (PACC), seem to play a central role in bipolar disorder (BD). However, the exact role of the PACC, and its functional connections to other midline regions (within and outside DMN) still remains unclear in BD. We investigated functional connectivity (FC), standard deviation (SD, as a measure of neuronal variability) and their correlation in bipolar patients (n = 40) versus healthy controls (n = 40), in the PACC and in its connections in different frequency bands (standard: 0.01-0.10 Hz; Slow-5: 0.01-0.027 Hz; Slow-4: 0.027-0.073 Hz). Finally, we studied the correlations between FC alterations and clinical-neuropsychological parameters and we explored whether subgroups of patients in different phases of the illness present different patterns of FC abnormalities. We found in BD decreased FC (especially in Slow-5) from the PACC to other regions located predominantly in the posterior DMN (such as the posterior cingulate cortex (PCC) and inferior temporal gyrus) and in the SN (such as the supragenual anterior cingulate cortex and ventrolateral prefrontal cortex). Second, we found in BD a decoupling between PACC-based FC and variability in the various target regions (without alteration in variability itself). Finally, in our subgroups explorative analysis, we found a decrease in FC between the PACC and supragenual ACC (in depressive phase) and between the PACC and PCC (in manic phase). These findings suggest that in BD the communication, that is, information transfer, between the different cortical midline regions within the cingulate gyrus does not seem to work properly. This may result in dysbalance between different resting state networks like the DMN and SN. A deficit in the anterior DMN-SN connectivity

  14. High-field permanent-magnet structures

    International Nuclear Information System (INIS)

    Leupoid, H.A.

    1989-01-01

    This patent describes a permanent magnet structure. It comprises an azimuthally circumscribed section of a hollow hemispherical magnetic flux source, the magnetic orientation in the section with respect to the polar axis being substantially equal to twice the polar angle, a superconducting planar sheet abutting one flat face of the section along a longitudinal meridian, and at least one other planar sheet of selected material abutting another flat face of the section and perpendicular to the first-mentioned sheet

  15. Quantum field theory and nuclear structure

    International Nuclear Information System (INIS)

    Celenza, L.S.; Goulard, B.; Shakin, C.M.

    1981-01-01

    We discuss recent successful calculations of the properties of nuclear matter within the context of theories exhibiting mass generation through spontaneous symmetry breaking. We start with the sigma model of Gell-Mann and Levy and introduce the nucleon mass (in a vacuum) in the usual manner. We relate the expectation value of the sigma field in a vacuum to a finite value of the scalar density. If the vacuum is now filled with nucleons (nuclear matter) the scalar density is increased and the new value for the nucleon mass must be determined. We exhibit the equation whose solution determines the new mass, and we also define a perturbative scheme for the determination of this mass. This scheme involves an expansion of the various quantities of the theory in terms of matrix elements calculated with positive- and negative-energy spinors parametrized with the vacuum mass. Although the decrease in the mass upon going from vacuum to nuclear matter at the equilibrium density is quite large (approx.400 MeV), we are still able to exhibit a small parameter which allows for a perturbative expansion of the binding energy and other observables. The leading term in such an expansion reproduces the approximation widely used in other calculations of the properties of nuclear matter. The truncation of the expansion at the leading term is inadequate and this fact accounts for the lack of success in previous calculations using the standard formalism. We proceed to make a transformation to the Weinberg Lagrangian retaining the fluctuating parts of the sigma field. We further make a small-oscillation approximation, dropping the nonlinear terms in this Lagrangian

  16. Quantum field theory approaches to meson structure

    International Nuclear Information System (INIS)

    Branz, Tanja

    2011-01-01

    Meson spectroscopy became one of the most interesting topics in particle physics in the last ten years. In particular, the discovery of new unexpected states in the charmonium spectrum which cannot be simply explained by the constituent quark model attracted the interest of many theoretical efforts. In the present thesis we discuss different meson structures ranging from light and heavy quark-antiquark states to bound states of hadrons-hadronic molecules. Here we consider the light scalar mesons f 0 (980) and a 0 (980) and the charmonium-like Y(3940), Y(4140) and Z ± (4430) states. In the discussion of the meson properties like mass spectrum, total and partial decay widths and production rates we introduce three different theoretical methods for the treatment and description of hadronic structure. For the study of bound states of mesons we apply a coupled channel approach which allows for the dynamical generation of meson-meson resonances. The decay properties of meson molecules are further on studied within a second model based on effective Lagrangians describing the interaction of the bound state and its constituents. Besides hadronic molecules the effective Lagrangian approach is also used to study the radiative and strong decay properties of ordinary quark-antiquark (q anti q) states. The AdS/QCD model forms the completion of the three theoretical methods introduced in the present thesis. This holographic model provides a completely different ansatz and is based on extra dimensions and string theory. Within this framework we calculate the mass spectrum of light and heavy mesons and their decay constants.

  17. Structure of the urban moisture field

    International Nuclear Information System (INIS)

    Sisterson, D.L.; Dirks, R.A.

    1975-01-01

    In the 26 July 1974 case study in St. Louis as a part of Project METROMEX, aircraft and surface network stations were used to determine specific humidity and potential temperature patterns near the surface and at two levels within the mixing layer. From the data acquired at these three levels, three-dimensional analyses of the moisture fields in the mixing layer were constructed. The mesoscale dry regions observed throughout the mixing layer correspond to the more impervious surfaces of the urban area. From energy budget considerations, latent heat fluxes are small over these impervious surfaces owing to the large runoff of precipitation and the lack of moisture retention capabilities. Hence, urbanization obviously alters the local energy budget. Surface boundary layer conditions are determined by heat and moisture fluxes. A new internal boundary layer within the city is formed after the breakdown of the radiation inversion in order to compensate for the alteration of sensible heat and latent heat energies. Hence, isolated semistagnant urban air is replenished by moisture only as quickly as evapotranspiration from impervious surfaces will allow. The city surface, therefore, is not a sink of moisture, but rather a reduced source relative to rural areas

  18. What is Bipolar Disorder?

    Science.gov (United States)

    ... down” Have trouble sleeping Think about death or suicide Can someone have bipolar disorder along with other problems? Yes. Sometimes people having very strong mood episodes may have psychotic symptoms. Psychosis affects thoughts ...

  19. Organizational Fields and the Structuration Perspective: Analytical Possibilities

    Directory of Open Access Journals (Sweden)

    Clóvis L. Machado-da-Silva

    2006-07-01

    Full Text Available The concept of the organizational field has been greatly dealt with in the literature on institutional theory in recent years. As the concept of field involves a relational and symbolic dimension, we propose that the theory of structuration, based on the logic of recursiveness between agency and structure should be adapted to theunderstanding of the field dynamically. In this way, the objective of this theoretical essay is to deal with the dynamic of the organizational field using structurationist logic, allowing that from this logic we recall both the importance of the practice in the structuration process of the organizational field and the historical and recursive character which may constrain or enable the actions of social actors. To this end, we revise the concept of field in different perspectives of analysis, reflecting on the implication of the theoretical presuppositions of each approach and then discuss in a critical manner the theoretical foundation of the structuration process of organizational fields based on the structurationist approach. We conclude the paper with propositions pertaining to the revision of the concept of field from a multiparadigmatic viewpoint in which structure and agency are recursively implied.

  20. Novel antipsychotics in bipolar and schizoaffective mania

    NARCIS (Netherlands)

    Slooff, CJ

    Objective: Novel antipsychotics are increasingly used in the treatment of bipolar and schizoaffective mania. This paper presents an overview of the controlled studies in this field. Method: Using cross-references, a computerized search was performed on MEDLINE and EMBASE psychiatry covering the

  1. Algebraic structure of general electromagnetic fields and energy flow

    International Nuclear Information System (INIS)

    Hacyan, Shahen

    2011-01-01

    Highlights: → Algebraic structure of general electromagnetic fields in stationary spacetime. → Eigenvalues and eigenvectors of the electomagnetic field tensor. → Energy-momentum in terms of eigenvectors and Killing vector. → Explicit form of reference frame with vanishing Poynting vector. → Application of formalism to Bessel beams. - Abstract: The algebraic structures of a general electromagnetic field and its energy-momentum tensor in a stationary space-time are analyzed. The explicit form of the reference frame in which the energy of the field appears at rest is obtained in terms of the eigenvectors of the electromagnetic tensor and the existing Killing vector. The case of a stationary electromagnetic field is also studied and a comparison is made with the standard short-wave approximation. The results can be applied to the general case of a structured light beams, in flat or curved spaces. Bessel beams are worked out as example.

  2. Ion transport Modeling in a Bipolar Membrane

    International Nuclear Information System (INIS)

    Kim, Jung Soo; Park, Kwang Heon; Kim, Kwang Wook

    2010-01-01

    The COL(Carbonate-based Oxidative Leaching) process is an environmentally-friendly technique for collecting only uranium from spent fuel with oxidation leaching/ precipitation of carbonate solution. The bipolar membrane used for the electrolyte circulation of the salt used in the COL process is a special form of ion exchange membrane which combines CEM(cation exchange membrane) and AEM(anion exchange membrane). After arranging positive ion exchange layer toward negative terminal and positive ion exchange layer toward positive terminal, then supply electricity, water molecules are decomposed into protons and hydroxyl ions by a strong electric field in the transition region inside bipolar membrane.1) In this study, a theoretical approach to increase the efficiency of Na + and NO3 - ion collecting device using bipolar membrane was taken and simulating using the COMSOL program was tried. The details of results are also discussed

  3. Common and distinct structural features of schizophrenia and bipolar disorder: The European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT study.

    Directory of Open Access Journals (Sweden)

    Eleonora Maggioni

    Full Text Available Although schizophrenia (SCZ and bipolar disorder (BD share elements of pathology, their neural underpinnings are still under investigation. Here, structural Magnetic Resonance Imaging (MRI data collected from a large sample of BD and SCZ patients and healthy controls (HC were analyzed in terms of gray matter volume (GMV using both voxel based morphometry (VBM and a region of interest (ROI approach.The analysis was conducted on two datasets, Dataset1 (802 subjects: 243 SCZ, 176 BD, 383 HC and Dataset2, a homogeneous subset of Dataset1 (301 subjects: 107 HC, 85 BD and 109 SCZ. General Linear Model analyses were performed 1 at the voxel-level in the whole brain (VBM study, 2 at the regional level in the anatomical regions emerged from the VBM study (ROI study. The GMV comparison across groups was integrated with the analysis of GMV correlates of different clinical dimensions.The VBM results of Dataset1 showed 1 in BD compared to HC, GMV deficits in right cingulate, superior temporal and calcarine cortices, 2 in SCZ compared to HC, GMV deficits in widespread cortical and subcortical areas, 3 in SCZ compared to BD, GMV deficits in insula and thalamus (p<0.05, cluster family wise error corrected. The regions showing GMV deficits in the BD group were mostly included in the SCZ ones. The ROI analyses confirmed the VBM results at the regional level in most of the clusters from the SCZ vs. HC comparison (p<0.05, Bonferroni corrected. The VBM and ROI analyses of Dataset2 provided further evidence for the enhanced GMV deficits characterizing SCZ. Based on the clinical-neuroanatomical analyses, we cannot exclude possible confounding effects due to 1 age of onset and medication in BD patients, 2 symptoms severity in SCZ patients.Our study reported both shared and specific neuroanatomical characteristics between the two disorders, suggesting more severe and generalized GMV deficits in SCZ, with a specific role for insula and thalamus.

  4. Common and distinct structural features of schizophrenia and bipolar disorder: The European Network on Psychosis, Affective disorders and Cognitive Trajectory (ENPACT) study

    Science.gov (United States)

    Crespo-Facorro, Benedicto; Nenadic, Igor; Benedetti, Francesco; Gaser, Christian; Sauer, Heinrich; Roiz-Santiañez, Roberto; Poletti, Sara; Marinelli, Veronica; Bellani, Marcella; Perlini, Cinzia; Ruggeri, Mirella; Altamura, A. Carlo; Diwadkar, Vaibhav A.; Brambilla, Paolo

    2017-01-01

    Introduction Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology, their neural underpinnings are still under investigation. Here, structural Magnetic Resonance Imaging (MRI) data collected from a large sample of BD and SCZ patients and healthy controls (HC) were analyzed in terms of gray matter volume (GMV) using both voxel based morphometry (VBM) and a region of interest (ROI) approach. Methods The analysis was conducted on two datasets, Dataset1 (802 subjects: 243 SCZ, 176 BD, 383 HC) and Dataset2, a homogeneous subset of Dataset1 (301 subjects: 107 HC, 85 BD and 109 SCZ). General Linear Model analyses were performed 1) at the voxel-level in the whole brain (VBM study), 2) at the regional level in the anatomical regions emerged from the VBM study (ROI study). The GMV comparison across groups was integrated with the analysis of GMV correlates of different clinical dimensions. Results The VBM results of Dataset1 showed 1) in BD compared to HC, GMV deficits in right cingulate, superior temporal and calcarine cortices, 2) in SCZ compared to HC, GMV deficits in widespread cortical and subcortical areas, 3) in SCZ compared to BD, GMV deficits in insula and thalamus (p<0.05, cluster family wise error corrected). The regions showing GMV deficits in the BD group were mostly included in the SCZ ones. The ROI analyses confirmed the VBM results at the regional level in most of the clusters from the SCZ vs. HC comparison (p<0.05, Bonferroni corrected). The VBM and ROI analyses of Dataset2 provided further evidence for the enhanced GMV deficits characterizing SCZ. Based on the clinical-neuroanatomical analyses, we cannot exclude possible confounding effects due to 1) age of onset and medication in BD patients, 2) symptoms severity in SCZ patients. Conclusion Our study reported both shared and specific neuroanatomical characteristics between the two disorders, suggesting more severe and generalized GMV deficits in SCZ, with a specific role for

  5. Hints for electric-field compensation in multicell resonant structures

    Energy Technology Data Exchange (ETDEWEB)

    Fernandes, P; Parodi, R

    1981-03-31

    We propose a lumped-parameter equivalent circuit for a TM/sub 01/ multicell standing wave accelerating structure with full end cells. By the suggested model we can predict the amount of end cell frequency compensation needed to achieve field flatness in the highest mode of the structure.

  6. Design and Fabrication of the KSTAR Poloidal Field Coil Structure

    International Nuclear Information System (INIS)

    Park, H. K.; Choi, C. H.; Sa, J. W.

    2005-01-01

    The KSTAR magnet system consists of 16 toroidal field(TF) coils. 4 pairs of central solenoid(CS) coils, and 3 pairs of outer poloidal field(PF) coils. The TF coils are encased in a structure to enhance mechanical stability. The CS coil structure is supported on top of the TF coil structure and supplies a vertical compression of 15 MN to prevent lateral movement due to a repulsive force between the CS coils. The PF coil system is vertically symmetry to the machine mid-plane and consists of 6 coils and 80 support structures(i.e, 16 for PF5, 32 for PF6 and 32 fort PF7). All PF coil structures should absorb the thermal contraction difference between TF coil structure and PF coils due to cool down and endure the vertical and radial magnetic forces due to current charging. In order to satisfy these structural requirements. the PF5 coil structure is designed base on hinges and both of PF6 and PF7 coil structures based on flexible plates. The PF coil structures are assembled on the TF coil structure with an individual basement that is welded on the TF coil structure

  7. Bipolar Affective Disorder and Migraine

    Directory of Open Access Journals (Sweden)

    Birk Engmann

    2012-01-01

    Full Text Available This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and bipolar disorder, including both genetic and neuropathological approaches, is broadly discussed. Moreover, bipolar disorder and migraine are often combined with a variety of other affective disorders, and, furthermore, behavioural factors also play a role in the origin and course of the diseases. Approach to treatment options is also difficult. Several papers point out possible remedies, for example, valproate, topiramate, which acts on both diseases, but no first-choice treatments have been agreed upon yet.

  8. Depression and Bipolar Support Alliance

    Science.gov (United States)

    Depression and Bipolar Support Alliance Crisis Hotline Information Coping with a Crisis Suicide Prevention Information Psychiatric Hospitalization ... sign-up Education info, training, events Mood Disorders Depression Bipolar Disorder Anxiety Screening Center Co-occurring Illnesses/ ...

  9. Construction of alternative Hamiltonian structures for field equations

    Energy Technology Data Exchange (ETDEWEB)

    Herrera, Mauricio [Departamento de Fisica, Facultad de Ciencias Fisicas y Matematicas, Universidad de Chile, Santiago (Chile); Hojman, Sergio A. [Departamento de Fisica, Facultad de Ciencias, Universidad de Chile, Santiago (Chile); Facultad de Educacion, Universidad Nacional Andres Bello, Santiago (Chile); Centro de Recursos Educativos Avanzados, CREA, Santiago (Chile)

    2001-08-10

    We use symmetry vectors of nonlinear field equations to build alternative Hamiltonian structures. We construct such structures even for equations which are usually believed to be non-Hamiltonian such as heat, Burger and potential Burger equations. We improve on a previous version of the approach using recursion operators to increase the rank of the Poisson bracket matrices. Cole-Hopf and Miura-type transformations allow the mapping of these structures from one equation to another. (author)

  10. Gauge structure of neutral-vector field theory. [Massive vector fields, massless limits

    Energy Technology Data Exchange (ETDEWEB)

    Kubo, R; Yokoyama, [Hiroshima univ., Takehara (Japan). Research Inst. for Theoretical Physics

    1975-03-01

    General aspects of gauge structure of neutral-vector field theory are investigated from an extended standpoint, where massive vector fields are treated in a form corresponding to the electromagnetic fields in a general gauge formalism reported previously. All results obtained are shown to have unique massless limits. It is shown that a generalized q-number gauge transformation for fields makes the theory invariant in cooperation with a simultaneous transformation for relevant gauge parameters. A method of differentiation with respect to a gauge variable is found to clarify some essential features of the gauge structure. Two possible types of gauge structure also emerge correspondingly to the massless case. A neutral-vector field theory proposed in a preceding paper is included in the present framework as the most preferable case.

  11. [Differences in Subjective Experience Between Unipolar and Bipolar Depression].

    Science.gov (United States)

    Fierro, Marco; Bustos, Andrés; Molina, Carlos

    2016-01-01

    It is important to make distinction between bipolar and unipolar depression because treatment and prognosis are different. Since the diagnosis of the two conditions is purely clinical, find symptomatic differences is useful. Find differences in subjective experience (first person) between unipolar and bipolar depression. Phenomenological-oriented qualitative exploratory study of 12 patients (7 with bipolar depression and 5 with unipolar depression, 3 men and 9 women). We used a semi-structured interview based on Examination of Anomalous Self-Experience (EASE). The predominant mood in bipolar depression is emotional dampening, in unipolar is sadness. The bodily experience in bipolar is of a heavy, tired body; an element that inserts between the desires of acting and performing actions and becomes an obstacle to the movement. In unipolar is of a body that feels more comfortable with the stillness than activity, like laziness of everyday life. Cognition and the stream of consciousness: in bipolar depression, compared with unipolar, thinking is slower, as if to overcome obstacles in their course. There are more difficult to understand what is heard or read. Future perspective: in bipolar depression, hopelessness is stronger and broader than in unipolar, as if the very possibility of hope was lost. Qualitative differences in predominant mood, bodily experience, cognition and future perspective were found between bipolar and unipolar depression. Copyright © 2015 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  12. Bipolar Disorder and Cancer

    Directory of Open Access Journals (Sweden)

    Sermin Kesebir

    2012-06-01

    Full Text Available Prevalence studies and studies on causation relations have shown that the relation between psychiatric disorders and chronic physical diseases is neglected. For heterogeneous diseases an increasing number of susceptibility variants are being defined. Alzheimer disease, bipolar disorder, breast and prostate cancer, coronary artery disease, Chron's disease, systemic lupus eritematosus, type 1 and type 2 diabetes mellitus are mentioned together with epigenetic concept. In acrocentric zone of chromosome 13, breast cancer, retinoblastoma, chronic Iymphocytic leukemia genes with B cells, dopamin loci of bipolar disorder are found together. Among bipolar and healthy individuals, an increase risk of breast cancer in female cases has been resported. On the other hand, psychosocial factors that affect stress and response to stress itself may be important variables in prognosis and progression of different cancer types. During the course of many cancer types –especially brain tumors- and during treatment of chemotherapeutic agents, bipolar symptomatology may appear. In this article, it is reviewed with relevant literature that whether an etiological relation between bipolar disorder and cancer exist and how both diseases affect each other's course and treatment.

  13. A study of genetic and environmental contributions to structural brain changes over time in twins concordant and discordant for bipolar disorder

    NARCIS (Netherlands)

    Bootsman, F.; Brouwer, R. M.; Schnack, H. G.; Kemner, S. M.; Hillegers, M. H. J.; Sarkisyan, G.; van der Schot, A. C.; Vonk, R.; Pol, H. E. Hulshoff; Nolen, W. A.; Kahn, R. S.; van Haren, N. E. M.

    This is the first longitudinal twin study examining genetic and environmental contributions to the association between liability to bipolar disorder (BD) and changes over time in global brain volumes, and global and regional measures of cortical surface area, cortical thickness and cortical volume.

  14. A Built-In Self-Test Structure (BIST) for Resistive RAMs characterization: Application to bipolar OxRRAM

    Science.gov (United States)

    Aziza, H.; Bocquet, M.; Moreau, M.; Portal, J.-M.

    2015-01-01

    Resistive Random Access Memory (RRAM) is a form of nonvolatile storage that operates by changing the resistance of a specially formulated solid dielectric material [1]. Among RRAMs, oxide-based Resistive RAMs (so-called OxRRAMs) are promising candidates due their compatibility with CMOS processes and high ON/OFF resistance ratio. Common problems with OxRRAM are related to high variability in operating conditions and low yield. OxRRAM variability mainly impact ON/OFF resistance ratio. This ratio is a key parameter to determine the overall performance of an OxRRAM memory. In this context, the presented built-in structure allows collecting statistical data related to the OxRRAM memory array (ON/OFF resistance distributions) for reliability assessment of the technology.

  15. Attention deficit hyperactivity disorder and bipolar mood disorder in ...

    African Journals Online (AJOL)

    2009-06-19

    Jun 19, 2009 ... Bipolar mood disorder (BMD) has traditionally been seen as an adult disorder and .... antisocial behaviour, such as conduct disorder.3. In young ... In personality structure and temperament, children with BMD are more likely to ...

  16. The structure of magnetic field in the TEXTOR-DED

    International Nuclear Information System (INIS)

    Finken, K.H.; Abdullaev, S.S.; Jakubowski, M.; Lehnen, M.; Nicolai, A.; Spatschek, K.H.

    2005-01-01

    The main component of the Dynamic Ergodic Divertor (DED) consists of a set of coils installed in the TEXTOR tokamak which creates resonant magnetic perturbations, preferentially at the plasma edge. The main purpose of the DED is to study the effect of the magnetic perturbations on the tokamak plasma. In particular, on the transport of the heat and particles to wall, the plasma confinement and rotation. This report is devoted to the systematic theoretical study of magnetic field and its structure in the TEXTOR-DED. It contains the description of the DED coil system in different operational regimes, the magnetic field created by this coil system, the study of formation of chaotic magnetic field lines and the structure of stochastic (ergodic) zone of field lines at the plasma edge and on the divertor plates, determination of field line diffusion coefficients and the Kolmogorov lengths. The modern mapping method for integration of Hamiltonian field line equations is employed for these studies. A description of the numerical Gourdon code to study the ergodic zone of the DED is also given. The experimental observations of the structure magnetic field lines performed recently in the TEXTOR-DED and their comparison with the modelling are also briefly discussed. (orig.)

  17. Structural stability of interaction networks against negative external fields

    Science.gov (United States)

    Yoon, S.; Goltsev, A. V.; Mendes, J. F. F.

    2018-04-01

    We explore structural stability of weighted and unweighted networks of positively interacting agents against a negative external field. We study how the agents support the activity of each other to confront the negative field, which suppresses the activity of agents and can lead to collapse of the whole network. The competition between the interactions and the field shape the structure of stable states of the system. In unweighted networks (uniform interactions) the stable states have the structure of k -cores of the interaction network. The interplay between the topology and the distribution of weights (heterogeneous interactions) impacts strongly the structural stability against a negative field, especially in the case of fat-tailed distributions of weights. We show that apart from critical slowing down there is also a critical change in the system structure that precedes the network collapse. The change can serve as an early warning of the critical transition. To characterize changes of network structure we develop a method based on statistical analysis of the k -core organization and so-called "corona" clusters belonging to the k -cores.

  18. Coexistence of Cluster Structure and Mean-field-type Structure in Medium-weight Nuclei

    International Nuclear Information System (INIS)

    Taniguchi, Yasutaka; Horiuchi, Hisashi; Kimura, Masaaki

    2006-01-01

    We have studied the coexistence of cluster structure and mean-field-type structure in 20Ne and 40Ca using Antisymmetrized Molecular Dynamics (AMD) + Generator Coordinate Method (GCM). By energy variation with new constraint for clustering, we calculate cluster structure wave function. Superposing cluster structure wave functions and mean-field-type structure wave function, we found that 8Be-12C, α-36Ar and 12C-28Si cluster structure are important components of K π = 0 3 + band of 20Ne, that of normal deformed band of 40Ca and that of super deformed band of 40Ca, respectively

  19. Oxide bipolar electronics: materials, devices and circuits

    International Nuclear Information System (INIS)

    Grundmann, Marius; Klüpfel, Fabian; Karsthof, Robert; Schlupp, Peter; Schein, Friedrich-Leonhard; Splith, Daniel; Yang, Chang; Bitter, Sofie; Von Wenckstern, Holger

    2016-01-01

    We present the history of, and the latest progress in, the field of bipolar oxide thin film devices. As such we consider primarily pn-junctions in which at least one of the materials is a metal oxide semiconductor. A wide range of n-type and p-type oxides has been explored for the formation of such bipolar diodes. Since most oxide semiconductors are unipolar, challenges and opportunities exist with regard to the formation of heterojunction diodes and band lineups. Recently, various approaches have led to devices with high rectification, namely p-type ZnCo 2 O 4 and NiO on n-type ZnO and amorphous zinc-tin-oxide. Subsequent bipolar devices and applications such as photodetectors, solar cells, junction field-effect transistors and integrated circuits like inverters and ring oscillators are discussed. The tremendous progress shows that bipolar oxide electronics has evolved from the exploration of various materials and heterostructures to the demonstration of functioning integrated circuits. Therefore a viable, facile and high performance technology is ready for further exploitation and performance optimization. (topical review)

  20. Fabrication of the KSTAR toroidal field coil structure

    International Nuclear Information System (INIS)

    Choi, C.H.; Sa, J.W.; Park, H.K.; Hong, K.H.; Shin, H.; Kim, H.T.; Bak, J.S.; Lee, G.S.; Kwak, J.H.; Moon, H.G.; Yoon, H.H.; Lee, J.W.; Lee, S.K.; Song, J.Y.; Nam, K.M.; Byun, S.E.; Kim, H.C.; Ha, E.T.; Ahn, H.J.; Kim, D.S.; Lee, J.S.; Park, K.H.; Hong, C.D.

    2005-01-01

    The KSTAR toroidal field (TF) coil structure is under fabrication upon completion of engineering design and prototype construction. The prototype TF coil structure has been fabricated within allowable tolerances. Encasing of the prototype TF coil (TF00) in the prototype structure has been carried out through major processes involving a coil encasing, an enclosing weld, a vacuum pressure impregnation, and an outer surface machining. During the enclosing weld of the TF00 coil structure, we have measured temperatures and stresses on the coil surface. Assembly test had been performed with the TF00 coil structure. We have chosen Type 316LN as material of the TF coil structure. We used the narrow-gap TIG welding method. Doosan Heavy Industries and Construction Company (DHI) will complete the fabrication of the TF coil structure in Feb. 2006. (author)

  1. Distillation and Visualization of Spatiotemporal Structures in Turbulent Flow Fields

    International Nuclear Information System (INIS)

    Hege, Hans-Christian; Hotz, Ingrid; Kasten, Jens

    2011-01-01

    Although turbulence suggests randomness and disorder, organized motions that cause spatiotemporal 'coherent structures' are of particular interest. Revealing such structures in numerically given turbulent or semi-turbulent flows is of interest both for practically working engineers and theoretically oriented physicists. However, as long as there is no common agreement about the mathematical definition of coherent structures, extracting such structures is a vaguely defined task. Instead of searching for a general definition, the data visualization community takes a pragmatic approach and provides various tool chains implemented in flexible software frameworks that allow the user to extract distinct flow field structures. Thus physicists or engineers can select those flow structures which might advance their insight best. We present different approaches to distill important features from turbulent flows and discuss the necessary steps to be taken on the example of Lagrangian coherent structures.

  2. Temperature field simulation of complex structures in fire environment

    International Nuclear Information System (INIS)

    Li Weifen; Hao Zhiming; Li Minghai

    2010-01-01

    In this paper, the typical model of the system of dangerous goods - steel - wood composite structure including components of explosives is used as the research object. Using MARC program, the temperature field of the structure in the fire environment is simulated. Radiation, conduction and convection heat transfer within the gap of the structure are taken into account, contact heat transfer is also considered. The phenomenon of thermal decomposition of wood in high temperature is deal with by equivalent method. The results show that the temperature of the explosives is not high in the fire environment. The timber inside the composite structure has played a very good insulation effect of explosives.

  3. Periodical plasma structures controlled by external magnetic field

    Science.gov (United States)

    Schweigert, I. V.; Keidar, M.

    2017-11-01

    The plasma of Hall thruster type in external magnetic field is studied in 2D3V kinetic simulations using PIC MCC method. The periodical structure with maxima of electron and ion densities is formed and becomes more pronounced with increase of magnetic field incidence angle in the plasma. These ridges of electron and ion densities are aligned with the magnetic field vector and shifted relative each other. This leads to formation of two-dimensional double-layers structure in cylindrical plasma chamber. Depending on Larmor radius and Debye length up to nineteen potential steps appear across the oblique magnetic field. The electrical current gathered on the wall is associated with the electron and ion density ridges.

  4. Longitudinal- and transverse-wake-field effects in dielectric structures

    International Nuclear Information System (INIS)

    Rosing, M.; Gai, W.

    1990-01-01

    A dielectric-loaded circular waveguide structure is a potential high-gradient linear wake-field accelerator. A complete solution is given for the longitudinal electric and magnetic fields excited by a δ function and a Gaussian charge distribution moving parallel to the guide axis. The fields are then given in the limit of particle velocity equal to the speed of light. Example calculations are given for a structure with inner radius of 2 mm, outer radius of 5 mm, dielectric constant of 3, and total charge of 100 nC. Peak wake fields in excess of 200 MV/m are found. Azimuthal modes 0 and 1 are investigated for the particular interest of acceleration and deflection problems

  5. Methodological approaches in estimating anomalous geochemical field structure

    International Nuclear Information System (INIS)

    Gavrilov, R; Rudmin, M

    2015-01-01

    Mathematical statistic methods were applied to analyze the core samples from vertical expendable wells in Chertovo Koryto gold ore field. The following methods were used to analyse gold in samples: assay tests and atomic absorption method (AAS), while emission spectrum semiquantative method was applied to identify traces. The analysis of geochemical association distribution in one central profile demonstrated that bulk metasomatic aureoles are characteristic of concentric zonal structure. The distribution of geochemical associations is correlated to the hydrothermal stages of mineral formation identified in this deposit. It was proved that the processed geochemical data by factor and cluster analyses provided additional information on the anomalous geochemical field structure in gold- bearing black-shale strata. Such methods are effective tools in interpretating specific features of geochemical field structures in analogous potential ore-bearing areas

  6. Combinatorial vector fields and the valley structure of fitness landscapes.

    Science.gov (United States)

    Stadler, Bärbel M R; Stadler, Peter F

    2010-12-01

    Adaptive (downhill) walks are a computationally convenient way of analyzing the geometric structure of fitness landscapes. Their inherently stochastic nature has limited their mathematical analysis, however. Here we develop a framework that interprets adaptive walks as deterministic trajectories in combinatorial vector fields and in return associate these combinatorial vector fields with weights that measure their steepness across the landscape. We show that the combinatorial vector fields and their weights have a product structure that is governed by the neutrality of the landscape. This product structure makes practical computations feasible. The framework presented here also provides an alternative, and mathematically more convenient, way of defining notions of valleys, saddle points, and barriers in landscape. As an application, we propose a refined approximation for transition rates between macrostates that are associated with the valleys of the landscape.

  7. Differential pattern of semantic memory organization between bipolar I and II disorders.

    Science.gov (United States)

    Chang, Jae Seung; Choi, Sungwon; Ha, Kyooseob; Ha, Tae Hyon; Cho, Hyun Sang; Choi, Jung Eun; Cha, Boseok; Moon, Eunsoo

    2011-06-01

    Semantic cognition is one of the key factors in psychosocial functioning. The aim of this study was to explore the differences in pattern of semantic memory organization between euthymic patients with bipolar I and II disorders using the category fluency task. Study participants included 23 euthymic subjects with bipolar I disorder, 23 matched euthymic subjects with bipolar II disorder and 23 matched control subjects. All participants were assessed for verbal learning, recall, learning strategies, and fluency. The combined methods of hierarchical clustering and multidimensional scaling were used to compare the pattern of semantic memory organization among the three groups. Quantitative measures of verbal learning, recall, learning strategies, and fluency did not differ between the three groups. A two-cluster structure of semantic memory organization was identified for the three groups. Semantic structure was more disorganized in the bipolar I disorder group compared to the bipolar II disorder. In addition, patients with bipolar II disorder used less elaborate strategies of semantic memory organization than those of controls. Compared to healthy controls, strategies for categorization in semantic memory appear to be less knowledge-based in patients with bipolar disorders. A differential pattern of semantic memory organization between bipolar I and II disorders indicates a higher risk of cognitive abnormalities in patients with bipolar I disorder compared to patients with bipolar II disorder. Exploring qualitative nature of neuropsychological domains may provide an explanatory insight into the characteristic behaviors of patients with bipolar disorders. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. String field theory. Algebraic structure, deformation properties and superstrings

    International Nuclear Information System (INIS)

    Muenster, Korbinian

    2013-01-01

    This thesis discusses several aspects of string field theory. The first issue is bosonic open-closed string field theory and its associated algebraic structure - the quantum open-closed homotopy algebra. We describe the quantum open-closed homotopy algebra in the framework of homotopy involutive Lie bialgebras, as a morphism from the loop homotopy Lie algebra of closed string to the involutive Lie bialgebra on the Hochschild complex of open strings. The formulation of the classical/quantum open-closed homotopy algebra in terms of a morphism from the closed string algebra to the open string Hochschild complex reveals deformation properties of closed strings on open string field theory. In particular, we show that inequivalent classical open string field theories are parametrized by closed string backgrounds up to gauge transformations. At the quantum level the correspondence is obstructed, but for other realizations such as the topological string, a non-trivial correspondence persists. Furthermore, we proof the decomposition theorem for the loop homotopy Lie algebra of closed string field theory, which implies uniqueness of closed string field theory on a fixed conformal background. Second, the construction of string field theory can be rephrased in terms of operads. In particular, we show that the formulation of string field theory splits into two parts: The first part is based solely on the moduli space of world sheets and ensures that the perturbative string amplitudes are recovered via Feynman rules. The second part requires a choice of background and determines the real string field theory vertices. Each of these parts can be described equivalently as a morphism between appropriate cyclic and modular operads, at the classical and quantum level respectively. The algebraic structure of string field theory is then encoded in the composition of these two morphisms. Finally, we outline the construction of type II superstring field theory. Specific features of the

  9. Unipolar and bipolar diffusion charging of ultrafine particles

    International Nuclear Information System (INIS)

    Adachi, Motoaki; Okuyama, Kikuo; Kousaka, Yasuo.

    1985-01-01

    Unipolar and bipolar diffusion charging of monodisperse ultrafine particles of 4 - 100 nm in diameter has been studied experimentally and theoretically. The particles were charged by unipolar and bipolar ions generated by α-ray irradiation and the charge distribution of particles was directly observed in the electric field after the growth of them by condensation of di-butyl phthalate vapor. In both cases of unipolar and bipolar charging, the experimental results have been found in good agreement with the solution of basic equations where Fuchs' formula is used as the combination probability of an ion with a particle. (author)

  10. Field emission properties of an array of pyramidal structures

    Energy Technology Data Exchange (ETDEWEB)

    De Assis, Thiago A [Departamento de QuImica, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); Borondo, F [Departamento de QuImica, Instituto Mixto de Ciencias Matematicas CSIC-UAM-UC3M-UCM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid (Spain); De Castilho, C M C; Brito Mota, F [Grupo de Fisica de SuperfIcies e Materiais, Instituto de Fisica, Universidade Federal da Bahia, Campus Universitario da Federacao, 40210-340, Salvador, BA (Brazil); Benito, R M, E-mail: t.albuquerque@uam.e, E-mail: f.borondo@uam.e, E-mail: caio@ufba.b, E-mail: fbmota@ufba.b, E-mail: rosamaria.benito@upm.e [Grupo de Sistemas Complejos, Departamento de Fisica y Mecanica, Escuela Tecnica Superior de Ingenieros Agronomos, Universidad Politecnica de Madrid, Ciudad Universitaria, 28040 Madrid (Spain)

    2009-10-07

    The properties and efficiency of the emission current density produced by a metallic array of pyramidal structures are investigated. The theoretical results obtained by numerical integration of the corresponding Laplace equation using a finite differences scheme offer useful information for the optimization of field emission devices based on cathodes with this geometry. Our study shows that the inter-pyramidal distance strongly affects the current density, and even more important for this issue is the protrusion characteristics of these structures. Another relevant, although less important, parameter determining this density is the anode-cathode distance. The effect of the array characteristics on the maximum local electric field intensity is also discussed.

  11. Aerodynamic structures and processes in rotationally augmented flow fields

    DEFF Research Database (Denmark)

    Schreck, S.J.; Sørensen, Niels N.; Robinson, M.C.

    2007-01-01

    . Experimental measurements consisted of surface pressure data statistics used to infer sectional boundary layer state and to quantify normal force levels. Computed predictions included high-resolution boundary layer topologies and detailed above-surface flow field structures. This synergy was exploited...... to reliably identify and track pertinent features in the rotating blade boundary layer topology as they evolved in response to varying wind speed. Subsequently, boundary layer state was linked to above-surface flow field structure and used to deduce mechanisms; underlying augmented aerodynamic force...

  12. Periodical plasma structures controlled by external magnetic field

    Science.gov (United States)

    Schweigert, I. V.; Keidar, M.

    2017-06-01

    The characteristics of two-dimensional periodical structures in a magnetized plasma are studied using kinetic simulations. Ridges (i.e. spikes in electron and ion density) are formed and became more pronounced with an increase of magnetic field incidence angle in the plasma volume in the cylindrical chamber. These ridges are shifted relative to each other, which results in the formation of a two-dimensional double-layer structure. Depending on Larmor radius and Debye length up to 19 potential steps appear across the oblique magnetic field. The electrical current gathered into the channels is associated with the electron and ion density ridges.

  13. Computation of wave fields and soil structure interaction

    International Nuclear Information System (INIS)

    Lysmer, J.W.

    1982-01-01

    The basic message of the lecture is that the determination of the temporal and spatial variation of the free-field motions is the most important part of any soil-structure interaction analysis. Any interaction motions may be considered as small aberrations superimposed on the free-field motions. The current definition of the soil-structure interaction problem implies that superposition must be used, directly or indirectly, in any rational method of analysis of this problem. This implies that the use of nonlinear procedures in any part of a soil-structure interaction analysis must be questioned. Currently the most important part of the soil-structure interaction analysis, the free-field problem, cannot be solved by nonlinear methods. Hence, it does not seem reasonable to spend a large effort on trying to obtain nonlinear solutions for the interaction part of the problem. Even if such solutions are obtained they cannot legally be superimposed on the free-field motions to obtain the total motions of the structure. This of course does not preclude the possibility that such an illegal procedure may lead to solutions which are close enough for engineering purposes. However, further research is required to make a decision on this issue

  14. Temperature dependency of silicon structures for magnetic field gradient sensing

    Science.gov (United States)

    Dabsch, Alexander; Rosenberg, Christoph; Stifter, Michael; Keplinger, Franz

    2018-02-01

    This work describes the temperature dependence of two sensors for magnetic field gradient sensors and demonstrates a structure to compensate for the drift of resonance frequency over a wide temperature range. The temperature effect of the sensing element is based on internal stresses induced by the thermal expansion of material, therefore FEM is used to determine the change of the eigenvalues of the sensing structure. The experimental setup utilizes a Helmholtz coil system to generate the magnetic field and to excite the MEMS structure with Lorentz forces. The MEMS structure is placed on a plate heated with resistors and cooled by a Peltier element to control the plate temperature. In the second part, we describe how one can exploit temperature sensitivity for temperature measurements and we show the opportunity to include the temperature effect to increase the sensitivity of single-crystal silicon made flux density gradient sensors.

  15. Structural analysis of TFTR toroidal field coil conceptual design

    International Nuclear Information System (INIS)

    Smith, R.A.

    1975-10-01

    The conceptual design evaluation of the V-shaped toroidal field coils on the Tokamak Fusion Test Reactor has been performed by detailed structural analysis with the finite element method. The innovation provided by this design and verified in this work is the capability to support toroidal field loads while simultaneously performing the function of twist restraint against the device axial torques resulting from the vertical field loads. The evaluations made for the conceptual design provide predictions for coil deflections and stresses. The results are available for the separate effects from toroidal fields, poloidal fields, and the thermal expansion of the coils as well as for the superposition of the primary loads and the primary plus thermal loads

  16. Investigation of the kinetics of parasitic leakages appearance and their annealing in microelectronic structures with isoplanar insulation; Issledovanie kinetiki vozniknoveniya i otzhiga parazitnykh utechek v miskroehlektronnykh strukturakh

    Energy Technology Data Exchange (ETDEWEB)

    Pershenkov, V S; Chujkin, V V

    1994-12-31

    Structural features of bipolar and CMOS microcircuits using a deep separating oxide are considered. Analysis of leakage occurrence kinetics at the expense of back-displaced transition edge electric field action is conducted.

  17. Torsional structural response from free-field ground motion

    International Nuclear Information System (INIS)

    Lam, P.C.; Scavuzzo, R.J.

    1979-01-01

    Torsional response of structures subjected to the action of both the free-field torsional inputs and external torque is investigated. By expanding the work of Scanlan, both lateral and torsional foundation inputs due to a travelling shear wave are derived from the free-field point motion. These free-field torsional motions are used as the basis of numerical studies. Response for different soil stiffness and structural characteristics are studied, as well as different dynamic models. In one dynamic model the structure is coupled to the soil using a compliance spring matrix and in the second model the structure coupled to an elastic half-space. Results of these two basic models are compared and found to be in good agreement. Finally, torsional structural response caused by torsional inputs is compared with lateral response caused by modified lateral inputs to determine the significance of torsional excitation on the seismic response of building structures. Numerical results show that these torsional seismic loads are as large or larger than those from modified lateral inputs. (orig.)

  18. Confirming the structure of negative beliefs about psychosis and bipolar disorder: A confirmatory factor analysis study of the Personal Beliefs about Experience Questionnaire and Personal Beliefs about Illness Questionnaire.

    Science.gov (United States)

    Taylor, Peter J; Pyle, Melissa; Schwannauer, Matthias; Hutton, Paul; Morrison, Anthony

    2015-11-01

    Negative beliefs about psychosis and other mental health difficulties may contribute to depression and distress in individuals with these experiences. The Personal Beliefs about Experience Questionnaire (PBEQ) and Personal Beliefs about Illness Questionnaire (PBIllQ) are two widely used measures of these beliefs. It is currently uncertain how the items on these measures map onto different underlying factors. This study therefore aimed to test the factor structure of these two measures. Confirmatory factor analysis (CFA) was used to test three alternative, pre-specified, factor structures for the PBIllQ and PBEQ in a sample of individuals diagnosed with bipolar disorder (n = 202) and a sample of individuals with experien-ces of psychosis (n = 362). Associations with depressive symptoms were also examined. A three-factor structure was supported for both measures, which included Negative Expectations/Appraisals (NEA), Internal Shame/Defectiveness (ISD) and External Shame (ES) factors. The NEA and ISD subscales also had consistent independent associations with depressive symptoms. The results suggest that the PBIllQ and PBEQ may capture three distinct sets of negative beliefs in individuals with psychosis or bipolar disorder and that these beliefs may have important consequences for subsequent difficulties in these populations such as depression. Both measures may be helpful in supporting assessment and formulation in clinical practice and in evaluating belief change in intervention trials. However, when used in these settings, the three subscales identified in this study may be the most valid way of calculating scores on these measures. Negative personal beliefs about the causes, meaning and consequences of psychosis and bipolar disorder are associated with greater distress and depression. Two related measures, the PBIllQ and PBEQ, have been developed to assess these beliefs. Our analyses suggest that scores on these questionnaires are best broken down into three

  19. Types of Bipolar Disorder

    Science.gov (United States)

    ... Events Home Science News Meetings and Events Multimedia Social Media Press Resources Newsletters NIMH News Feeds About Us ... has a lot of money, or has special powers. Someone having psychotic symptoms ... Substance Abuse: People with bipolar disorder may also misuse alcohol ...

  20. Discrete bipolar universal integrals

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    2014-01-01

    Roč. 252, č. 1 (2014), s. 55-65 ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * universal integral * Choquet integral Subject RIV: BA - General Mathematics Impact factor: 1.986, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0432224.pdf

  1. El trastorno bipolar

    OpenAIRE

    Freaza Rodríguez, Paula

    2014-01-01

    Se exponen los aspectos más relevantes del trastorno bipolar, entender qué significa este concepto, conocer los tipos que existen, qué otros trastornos suelen aparecer al mismo tiempo y qué tratamientos son los que dan mejores resultados

  2. Geometrical relationship of flare-generated solar wind structures to the magnetic axes of bipolar sunspot groups adjacent to their originating solar flares

    International Nuclear Information System (INIS)

    Ivanov, K.G.; Evdokimova, L.V.; Mikerina, N.V.

    1982-01-01

    Occurrences of interplanetary shock waves near the Earth after the powerful isolated flares of 1957-1978 are investigated. The close connection between the occurrences of shock waves and the positions of magnetic axes of bipolar groups of sunspots is suggested on the basis of a statistical study. The shock waves are principally observed when the Earth finds itself near the planes that are projected through the flares in parallel to the appropriate magnetic axes of the nearest bipolar groups. This regularity is interpreted as an indirect argument for a three-dimensional geometry for the interplanetary shock waves which, when projected on these flattened to corresponding planes, are traces of large circular arcs. The typical angular scales of isolated interplanetary shock waves are estimated as approx. equal to 150 0 and approx. equal to 30 0 parallel and perpendicular, respectively, to the magnetic axes correspondingly. (orig.)

  3. Simulation study of dynamo structure in reversed field pinch

    International Nuclear Information System (INIS)

    Nagata, A.; Sato, K.I.; Ashida, H.; Amano, T.

    1992-10-01

    The dynamo structure in the reversed field pinch (RFP) is studied through the nonlinear dynamics of single-helicity mode. Simulation is concentrated upon the physical structure of nonlinear interactions of the plasma flow and magnetic fluctuation. The result indicates that when the initial equilibrium profile is deformed by resistive diffusion, the radial flow is driven near the core of the plasma. As this flow forms a vortex structure and magnetic fluctuation grows radially, the dynamo electric field is spirally induced just inside the reversal surface and then the toroidal flux is increased. This dynamo electric field correlates to nonlinear evolution of the kinetic energy of m=1 mode, and the increase of the toroidal flux is originated in the growth process of the magnetic energy of this mode. Consequently, the RFP configuration can be sustained by the single-helicity evolution of m=1 mode alone, and the electric field induced by the interactions of the toroidal velocity and the radial magnetic field is the most dominant source on the dynamo action. (author)

  4. A Yang-Mills structure for string field theory

    International Nuclear Information System (INIS)

    Tsousheung Tsun

    1990-01-01

    String theorists believe that one way to achieve a fully quantized theory of string is through string field theory. The other way is to study conformal field theory on Riemann surfaces of different genera, which is the subject of many of the talks at this Conference. In a way, string field theory is the more conservative approach, since it aims just to replace the spacetime points of conventional quantum field theory by string, which are extended objects. However, from this point of view string theory has one rather unsatisfactory aspect, in the sense that although it has been very well developed and minutely studied, we are still rather unclear about its basic structure. We can contrast this to both general relativity, which is based on the geometry of spacetime, and to gauge theory, which is about the structure of various natural bundles over spacetime. And yet string theory is supposed to embody both these two essentially geometric theories. To paraphrase Witten, in string theory we seem to have to work backwards to get at the still unknown basic structure. Some joint work with Chan Hong-Mo is reported in an attempt to gain some understanding in that general direction. It seems that one could in some sense consider string field theory as a generalized Yang-Mills theory. This idea is explored. (author)

  5. Complex Colloidal Structures by Self-assembly in Electric Fields

    NARCIS (Netherlands)

    Vutukuri, H.R.

    2012-01-01

    The central theme of this thesis is exploiting the directed self-assembly of both isotropic and anisotropic colloidal particles to achieve the fabrication of one-, two-, and three-dimensional complex colloidal structures using external electric fields and/or a simple in situ thermal annealing

  6. Fine structure of fields in 2D photonic crystal waveguides

    DEFF Research Database (Denmark)

    Lavrinenko, Andrei; Volkov, V. S.; Bozhevolnyi, S. I.

    2006-01-01

    We resolve fine structure of fields in a single-row missing photonic crystal waveguide by finite-difference time-domain modelling and SNOM measurements. Both linear dispersion and slow-light regimes in proximity of the cutoff are addressed in the analysis....

  7. Giant Magnetic Field Enhancement in Hybridized MIM Structures

    KAUST Repository

    Alrasheed, Salma; Di Fabrizio, Enzo M.

    2017-01-01

    We propose numerically an approach to narrow the plasmon linewidth and enhance the magnetic near field intensity at a magnetic hot spot in a hybridized metal-insulatormetal (MIM) structure. First we insert in part of the dielectric layer of the MIM

  8. From quantum fields to fractal structures: intermittency in particle physics

    International Nuclear Information System (INIS)

    Peschanski, R.

    1991-01-01

    Some features and theoretical interpretations of the intermittency phenomenon observed in high-energy multi-particle production are recalled. One develops on the various connections found with fractal structuration of fluctuations in turbulence, spin-glass physics and aggregation phenomena described by the non-linear Smoluchowski equation. This may lead to a new approach to quantum field properties

  9. Self-consistent mean-field models for nuclear structure

    International Nuclear Information System (INIS)

    Bender, Michael; Heenen, Paul-Henri; Reinhard, Paul-Gerhard

    2003-01-01

    The authors review the present status of self-consistent mean-field (SCMF) models for describing nuclear structure and low-energy dynamics. These models are presented as effective energy-density functionals. The three most widely used variants of SCMF's based on a Skyrme energy functional, a Gogny force, and a relativistic mean-field Lagrangian are considered side by side. The crucial role of the treatment of pairing correlations is pointed out in each case. The authors discuss other related nuclear structure models and present several extensions beyond the mean-field model which are currently used. Phenomenological adjustment of the model parameters is discussed in detail. The performance quality of the SCMF model is demonstrated for a broad range of typical applications

  10. Optical properties of a multibarrier structure under intense laser fields

    Science.gov (United States)

    Ospina, D. A.; Akimov, V.; Mora-Ramos, M. E.; Morales, A. L.; Tulupenko, V.; Duque, C. A.

    2015-11-01

    Using the diagonalization method and within the effective mass and parabolic band approximations, the energy spectrum and the wave functions are investigated in biased multibarrier structure taking into account the effects of nonresonant intense laser fields. We calculated the optical properties from the susceptibility using a nonperturbative formalism recently reported. We study the changes in the intersubband optical absorption coefficients and refraction index for several values of the dressing laser parameter and for some specific values of the electric field applied along the growth direction of the heterostructure. It is concluded from our study that the peaks in the optical absorption spectrum have redshifts or blueshifts as a function of the laser parameter and the electric field. These parameters could be suitable tools for tuning the electronic and optical properties of the multibarrier structure.

  11. Clinical practice recommendations for bipolar disorder.

    Science.gov (United States)

    Malhi, G S; Adams, D; Lampe, L; Paton, M; O'Connor, N; Newton, L A; Walter, G; Taylor, A; Porter, R; Mulder, R T; Berk, M

    2009-01-01

    To provide clinically relevant evidence-based recommendations for the management of bipolar disorder in adults that are informative, easy to assimilate and facilitate clinical decision-making. A comprehensive literature review of over 500 articles was undertaken using electronic database search engines (e.g. MEDLINE, PsychINFO and Cochrane reviews). In addition articles, book chapters and other literature known to the authors were reviewed. The findings were then formulated into a set of recommendations that were developed by a multidisciplinary team of clinicians who routinely deal with mood disorders. These preliminary recommendations underwent extensive consultative review by a broader advisory panel that included experts in the field, clinical staff and patient representatives. The clinical practice recommendations for bipolar disorder (bipolar CPR) summarise evidence-based treatments and provide a synopsis of recommendations relating to each phase of the illness. They are designed for clinical use and have therefore been presented succinctly in an innovative and engaging manner that is clear and informative. These up-to-date recommendations provide an evidence-based framework that incorporates clinical wisdom and consideration of individual factors in the management of bipolar disorder. Further, the novel style and practical approach should promote their uptake and implementation.

  12. Bipolar disorder type I and II show distinct relationships between cortical thickness and executive function.

    Science.gov (United States)

    Abé, C; Rolstad, S; Petrovic, P; Ekman, C-J; Sparding, T; Ingvar, M; Landén, M

    2018-06-15

    Frontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects. Using a vertex-wise whole-brain analysis, we investigated how cortical integrity, as measured by cortical thickness, correlates with executive performance in patients with bipolar disorder type I, II, and controls (N = 160). We found focal associations between executive function and cortical thickness in the medial prefrontal cortex in bipolar II patients and controls, but not in bipolar I disorder. In bipolar II patients, we observed additional correlations in lateral prefrontal and occipital regions. Our findings suggest that bipolar disorder patients show altered structure-function relationships, and importantly that those relationships may differ between bipolar subtypes. The findings are line with studies suggesting subtype-specific neurobiological and cognitive profiles. This study contributes to a better understanding of brain structure-function relationships in bipolar disorder and gives important insights into the neuropathophysiology of diagnostic subtypes. © 2018 The Authors Acta Psychiatrica Scandinavica Published by John Wiley & Sons Ltd.

  13. ON BIPOLAR SINGLE VALUED NEUTROSOPHIC GRAPHS

    OpenAIRE

    Said Broumi; Mohamed Talea; Assia Bakali; Florentin Smarandache

    2016-01-01

    In this article, we combine the concept of bipolar neutrosophic set and graph theory. We introduce the notions of bipolar single valued neutrosophic graphs, strong bipolar single valued neutrosophic graphs, complete bipolar single valued neutrosophic graphs, regular bipolar single valued neutrosophic graphs and investigate some of their related properties.

  14. Implications of confining force field structures in hard hadronic processes

    International Nuclear Information System (INIS)

    Bengtsson, H.-U.

    1983-04-01

    This thesis is centered on the study of confining force field structures in hard scattering processes. Perturbative QCD provides the means of calculating any process on the parton level, but to be able accurately to describe the actual outcome of an event, one still needs a phenomenological model for how quarks and gluons transform into observable hadrons. One such model is based on the assumption that the particles are produced by the confining fields stretched between the partons. The actual particle distributions will then depend on the topology of the confining fields. We have developed a Monte Carlo program to simulate complete events in hard scattering, and we use this to study the properties of the confining field in different trigger situations. We further look at the amount of hard processes that can be expected in experiments that trigger on transverse energy sum (calorimeter experiments). Finally, we investigate charm production within our model. (author)

  15. Scale-up of Carbon/Carbon Bipolar Plates

    Energy Technology Data Exchange (ETDEWEB)

    David P. Haack

    2009-04-08

    This project was focused upon developing a unique material technology for use in PEM fuel cell bipolar plates. The carbon/carbon composite material developed in this program is uniquely suited for use in fuel cell systems, as it is lightweight, highly conductive and corrosion resistant. The project further focused upon developing the manufacturing methodology to cost-effectively produce this material for use in commercial fuel cell systems. United Technology Fuel Cells Corp., a leading fuel cell developer was a subcontractor to the project was interested in the performance and low-cost potential of the material. The accomplishments of the program included the development and testing of a low-cost, fully molded, net-shape carbon-carbon bipolar plate. The process to cost-effectively manufacture these carbon-carbon bipolar plates was focused on extensively in this program. Key areas for cost-reduction that received attention in this program was net-shape molding of the detailed flow structures according to end-user design. Correlations between feature detail and process parameters were formed so that mold tooling could be accurately designed to meet a variety of flow field dimensions. A cost model was developed that predicted the cost of manufacture for the product in near-term volumes and long-term volumes (10+ million units per year). Because the roduct uses lowcost raw materials in quantities that are less than competitive tech, it was found that the cost of the product in high volume can be less than with other plate echnologies, and can meet the DOE goal of $4/kW for transportation applications. The excellent performance of the all-carbon plate in net shape was verified in fuel cell testing. Performance equivalent to much higher cost, fully machined graphite plates was found.

  16. An investigation of coated aluminium bipolar plates for PEMFC

    International Nuclear Information System (INIS)

    Lin, Chien-Hung; Tsai, Sung-Ying

    2012-01-01

    Highlights: ► Coated aluminium bipolar plates demonstrate the hydrophobic property than the raw material. ► The corrosion behaviour of bipolar plate decreases the PEMFC performance severely. ► These PEMFCs are measured by current–voltage (I–V) curve test. ► The oxide film increases the interfacial contact resistance. -- Abstract: The performance of Al-alloy bipolar plates for the PEMFC (proton exchange membrane fuel cell) system is investigated in this paper. The metallic bipolar plates are modified with a Ni–P coating. The performance of the Al-alloy bipolar plates is evaluated by the coating structure, corrosion resistance, contact angle and single cell performance. The results indicate that the coated aluminium bipolar plates demonstrate hydrophobic and anti-corrosive properties. The hydrophobic property increases the contact angle on the surface from 46.08° to 80.51°. Meanwhile, the corrosion rate of the Ni–P coating can be over 1 order of magnitude lower than that of the substrate. Hence, the substrate with the coating maintains superior performance under the long term test. The present study proves that both the hydrophobicity and corrosion resistance significantly affect the metallic bipolar plate.

  17. Suicide attempts and clinical features of bipolar patients.

    Science.gov (United States)

    Berkol, Tonguç D; İslam, Serkan; Kırlı, Ebru; Pınarbaşı, Rasim; Özyıldırım, İlker

    2016-06-01

    To identify clinical predictors of suicide attempts in patients with bipolar disorder. This study included bipolar patients who were treated in the Psychiatry Department, Haseki Training and Research Hospital, Istanbul, Turkey, between 2013 and 2014; an informed consent was obtained from the participants. Two  hundred and eighteen bipolar patients were assessed by using the structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) Axis-I (SCID-I) in order to detect all possible psychiatric comorbid diagnoses. Clinical predictors of suicide attempts were examined in attempters and non-attempters. The study design was retrospective. The lifetime suicide attempt rate for the entire sample was 19.2%. Suicide attempters with bipolar disorder had more lifetime comorbidity of eating disorder. Female gender and family history of mood disorder were significant predictors for suicide attempts. There was no difference between groups in terms of bipolar disorder subtype, onset age of bipolar disorder, total number of episodes, first and predominant episode type, suicide history in first degree relatives, severity of episodes, and hospitalization and being psychotic. Our study revealed that female gender, family history of mood disorder, and eating disorder are more frequent in bipolar patients with at least one suicide attempt.

  18. Structural investigations of Great Basin geothermal fields: Applications and implications

    Energy Technology Data Exchange (ETDEWEB)

    Faulds, James E [Nevada Bureau of Mines and Geology, Univ. of Nevada, Reno, NV (United States); Hinz, Nicholas H. [Nevada Bureau of Mines and Geology, Univ. of Nevada, Reno, NV (United States); Coolbaugh, Mark F [Great Basin Center for Geothermal Energy, Univ. of Nevada, Reno, NV (United States)

    2010-11-01

    Because fractures and faults are commonly the primary pathway for deeply circulating hydrothermal fluids, structural studies are critical to assessing geothermal systems and selecting drilling targets for geothermal wells. Important tools for structural analysis include detailed geologic mapping, kinematic analysis of faults, and estimations of stress orientations. Structural assessments are especially useful for evaluating geothermal fields in the Great Basin of the western USA, where regional extension and transtension combine with high heat flow to generate abundant geothermal activity in regions having little recent volcanic activity. The northwestern Great Basin is one of the most geothermally active areas in the USA. The prolific geothermal activity is probably due to enhanced dilation on N- to NNE-striking normal faults induced by a transfer of NW-directed dextral shear from the Walker Lane to NW-directed extension. Analysis of several geothermal fields suggests that most systems occupy discrete steps in normal fault zones or lie in belts of intersecting, overlapping, and/or terminating faults. Most fields are associated with steeply dipping faults and, in many cases, with Quaternary faults. The structural settings favoring geothermal activity are characterized by subvertical conduits of highly fractured rock along fault zones oriented approximately perpendicular to the WNW-trending least principal stress. Features indicative of these settings that may be helpful in guiding exploration for geothermal resources include major steps in normal faults, interbasinal highs, groups of relatively low discontinuous ridges, and lateral jogs or terminations of mountain ranges.

  19. Structures of water molecules in carbon nanotubes under electric fields

    International Nuclear Information System (INIS)

    Winarto,; Takaiwa, Daisuke; Yamamoto, Eiji; Yasuoka, Kenji

    2015-01-01

    Carbon nanotubes (CNTs) are promising for water transport through membranes and for use as nano-pumps. The development of CNT-based nanofluidic devices, however, requires a better understanding of the properties of water molecules in CNTs because they can be very different from those in the bulk. Using all-atom molecular dynamics simulations, we investigate the effect of axial electric fields on the structure of water molecules in CNTs having diameters ranging from (7,7) to (10,10). The water dipole moments were aligned parallel to the electric field, which increases the density of water inside the CNTs and forms ordered ice-like structures. The electric field induces the transition from liquid to ice nanotubes in a wide range of CNT diameters. Moreover, we found an increase in the lifetime of hydrogen bonds for water structures in the CNTs. Fast librational motion breaks some hydrogen bonds, but the molecular pairs do not separate and the hydrogen bonds reform. Thus, hydrogen bonds maintain the water structure in the CNTs, and the water molecules move collectively, decreasing the axial diffusion coefficient and permeation rate

  20. Structural analyses of ITER toroidal field coils under fault conditions

    International Nuclear Information System (INIS)

    Jong, C.T.J.

    1992-04-01

    ITER (International Thermonuclear Experimental Reactor) is intended to be an experimental thermonuclear tokamak reactor testing the basic physics performance and technologies essential to future fusion reactors. The magnet system of ITER consists essentially of 4 sub-systems, i.e. toroidal field coils (TFCs), poloidal field coils (PFCs), power supplies, and cryogenic supplies. These subsystems do not contain significant radioactivity inventories, but the large energy inventory is a potential accident initiator. The aim of the structural analyses is to prevent accidents from propagating into vacuum vessel, tritium system and cooling system, which all contain significant amounts of radioactivity. As part of design process 3 conditions are defined for PF and TF coils, at which mechanical behaviour has to be analyzed in some detail, viz: normal operating conditions, upset conditions and fault conditions. This paper describes the work carried out by ECN to create a detailed finite element model of 16 TFCs as well as results of some fault condition analyses made with the model. Due to fault conditions, either electrical or mechanical, magnetic loading of TFCs becomes abnormal and further mechanical failure of parts of the overall structure might occur (e.g. failure of coil, gravitational supports, intercoil structure). The analyses performed consist of linear elastic stress analyses and electro-magneto-structural analyses (coupled field analyses). 8 refs.; 5 figs.; 5 tabs

  1. Protein Secondary Structure Prediction Using Deep Convolutional Neural Fields.

    Science.gov (United States)

    Wang, Sheng; Peng, Jian; Ma, Jianzhu; Xu, Jinbo

    2016-01-11

    Protein secondary structure (SS) prediction is important for studying protein structure and function. When only the sequence (profile) information is used as input feature, currently the best predictors can obtain ~80% Q3 accuracy, which has not been improved in the past decade. Here we present DeepCNF (Deep Convolutional Neural Fields) for protein SS prediction. DeepCNF is a Deep Learning extension of Conditional Neural Fields (CNF), which is an integration of Conditional Random Fields (CRF) and shallow neural networks. DeepCNF can model not only complex sequence-structure relationship by a deep hierarchical architecture, but also interdependency between adjacent SS labels, so it is much more powerful than CNF. Experimental results show that DeepCNF can obtain ~84% Q3 accuracy, ~85% SOV score, and ~72% Q8 accuracy, respectively, on the CASP and CAMEO test proteins, greatly outperforming currently popular predictors. As a general framework, DeepCNF can be used to predict other protein structure properties such as contact number, disorder regions, and solvent accessibility.

  2. The local structure of a Liouville vector field

    International Nuclear Information System (INIS)

    Ciriza, E.

    1990-05-01

    In this work we investigate the local structure of a Liouville vector field ξ of a Kaehler manifold (P,Ω) which vanishes on an isotropic submanifold Q of P. Some of the eigenvalues of its linear part at the singular points are zero and the remaining ones are in resonance. We show that there is a C 1 -smooth linearizing conjugation between the Liouville vector field ξ and its linear part. To do this we construct Darboux coordinates adapted to the unstable foliation which is provided by the Centre Manifold Theorem. We then apply recent linearization results due to G. Sell. (author). 11 refs

  3. The fixed point structure of lattice field theories

    International Nuclear Information System (INIS)

    Baier, R.; Reusch, H.J.; Lang, C.B.

    1989-01-01

    Monte-Carlo renormalization group methods allow to analyze lattice regularized quantum field theories. The properties of the quantized field theory in the continuum may be recovered at a critical point of the lattice model. This requires a study of the phase diagram and the renormalization flow structure of the coupling constants. As an example the authors discuss the results of a recent MCRG investigation of the SU(2) adjoint Higgs model, where they find evidence for the existence of a tricritical point at finite values of the inverse gauge coupling β

  4. The bipolar puzzle, adding new pieces. Factors associated with bipolar disorder, Genetic and environmental influences

    NARCIS (Netherlands)

    van der Schot, A.C.

    2009-01-01

    The focus of this thesis is twofold. The first part will discuss the structural brain abnormalities and schoolperformance associated with bipolar disorder and the influence of genetic and/or environmental factors to this association. It is part of a large twin study investigating several potential

  5. Computer modeling of electrical and thermal performance during bipolar pulsed radiofrequency for pain relief

    International Nuclear Information System (INIS)

    Pérez, Juan J.; Pérez-Cajaraville, Juan J.; Muñoz, Víctor; Berjano, Enrique

    2014-01-01

    Purpose: Pulsed RF (PRF) is a nonablative technique for treating neuropathic pain. Bipolar PRF application is currently aimed at creating a “strip lesion” to connect the electrode tips; however, the electrical and thermal performance during bipolar PRF is currently unknown. The objective of this paper was to study the temperature and electric field distributions during bipolar PRF. Methods: The authors developed computer models to study temperature and electric field distributions during bipolar PRF and to assess the possible ablative thermal effect caused by the accumulated temperature spikes, along with any possible electroporation effects caused by the electrical field. The authors also modeled the bipolar ablative mode, known as bipolar Continuous Radiofrequency (CRF), in order to compare both techniques. Results: There were important differences between CRF and PRF in terms of electrical and thermal performance. In bipolar CRF: (1) the initial temperature of the tissue impacts on temperature progress and hence on the thermal lesion dimension; and (2) at 37 °C, 6-min of bipolar CRF creates a strip thermal lesion between the electrodes when these are separated by a distance of up to 20 mm. In bipolar PRF: (1) an interelectrode distance shorter than 5 mm produces thermal damage (i.e., ablative effect) in the intervening tissue after 6 min of bipolar RF; and (2) the possible electroporation effect (electric fields higher than 150 kV m −1 ) would be exclusively circumscribed to a very small zone of tissue around the electrode tip. Conclusions: The results suggest that (1) the clinical parameters considered to be suitable for bipolar CRF should not necessarily be considered valid for bipolar PRF, and vice versa; and (2) the ablative effect of the CRF mode is mainly due to its much greater level of delivered energy than is the case in PRF, and therefore at same applied energy levels, CRF, and PRF are expected to result in same outcomes in terms of thermal

  6. Computer modeling of electrical and thermal performance during bipolar pulsed radiofrequency for pain relief

    Energy Technology Data Exchange (ETDEWEB)

    Pérez, Juan J. [Instituto de Investigación Interuniversitario en Bioingeniería y Tecnología Orientada al Ser Humano, Universitat Politècnica de València, Valencia 46022 (Spain); Pérez-Cajaraville, Juan J. [Pain Unit and Department of Anesthesia and Critical Care, Clínica Universidad de Navarra, University of Navarra, Pamplona 31008 (Spain); Muñoz, Víctor [Neurotherm Spain, Barcelona 08303 (Spain); Berjano, Enrique, E-mail: eberjano@eln.upv.es [Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València 46022 (Spain)

    2014-07-15

    Purpose: Pulsed RF (PRF) is a nonablative technique for treating neuropathic pain. Bipolar PRF application is currently aimed at creating a “strip lesion” to connect the electrode tips; however, the electrical and thermal performance during bipolar PRF is currently unknown. The objective of this paper was to study the temperature and electric field distributions during bipolar PRF. Methods: The authors developed computer models to study temperature and electric field distributions during bipolar PRF and to assess the possible ablative thermal effect caused by the accumulated temperature spikes, along with any possible electroporation effects caused by the electrical field. The authors also modeled the bipolar ablative mode, known as bipolar Continuous Radiofrequency (CRF), in order to compare both techniques. Results: There were important differences between CRF and PRF in terms of electrical and thermal performance. In bipolar CRF: (1) the initial temperature of the tissue impacts on temperature progress and hence on the thermal lesion dimension; and (2) at 37 °C, 6-min of bipolar CRF creates a strip thermal lesion between the electrodes when these are separated by a distance of up to 20 mm. In bipolar PRF: (1) an interelectrode distance shorter than 5 mm produces thermal damage (i.e., ablative effect) in the intervening tissue after 6 min of bipolar RF; and (2) the possible electroporation effect (electric fields higher than 150 kV m{sup −1}) would be exclusively circumscribed to a very small zone of tissue around the electrode tip. Conclusions: The results suggest that (1) the clinical parameters considered to be suitable for bipolar CRF should not necessarily be considered valid for bipolar PRF, and vice versa; and (2) the ablative effect of the CRF mode is mainly due to its much greater level of delivered energy than is the case in PRF, and therefore at same applied energy levels, CRF, and PRF are expected to result in same outcomes in terms of

  7. Computer modeling of electrical and thermal performance during bipolar pulsed radiofrequency for pain relief.

    Science.gov (United States)

    Pérez, Juan J; Pérez-Cajaraville, Juan J; Muñoz, Víctor; Berjano, Enrique

    2014-07-01

    Pulsed RF (PRF) is a nonablative technique for treating neuropathic pain. Bipolar PRF application is currently aimed at creating a "strip lesion" to connect the electrode tips; however, the electrical and thermal performance during bipolar PRF is currently unknown. The objective of this paper was to study the temperature and electric field distributions during bipolar PRF. The authors developed computer models to study temperature and electric field distributions during bipolar PRF and to assess the possible ablative thermal effect caused by the accumulated temperature spikes, along with any possible electroporation effects caused by the electrical field. The authors also modeled the bipolar ablative mode, known as bipolar Continuous Radiofrequency (CRF), in order to compare both techniques. There were important differences between CRF and PRF in terms of electrical and thermal performance. In bipolar CRF: (1) the initial temperature of the tissue impacts on temperature progress and hence on the thermal lesion dimension; and (2) at 37 °C, 6-min of bipolar CRF creates a strip thermal lesion between the electrodes when these are separated by a distance of up to 20 mm. In bipolar PRF: (1) an interelectrode distance shorter than 5 mm produces thermal damage (i.e., ablative effect) in the intervening tissue after 6 min of bipolar RF; and (2) the possible electroporation effect (electric fields higher than 150 kV m(-1)) would be exclusively circumscribed to a very small zone of tissue around the electrode tip. The results suggest that (1) the clinical parameters considered to be suitable for bipolar CRF should not necessarily be considered valid for bipolar PRF, and vice versa; and (2) the ablative effect of the CRF mode is mainly due to its much greater level of delivered energy than is the case in PRF, and therefore at same applied energy levels, CRF, and PRF are expected to result in same outcomes in terms of thermal damage zone dimension.

  8. MAGNETIC FIELD IN ATYPICAL PROMINENCE STRUCTURES: BUBBLE, TORNADO, AND ERUPTION

    Energy Technology Data Exchange (ETDEWEB)

    Levens, P. J.; Labrosse, N. [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow G12 8QQ (United Kingdom); Schmieder, B. [LESIA, Observatoire de Paris, PSL Research University, CNRS, Sorbonne Universités, UPMC Univ. Paris 06, Univ. Paris Diderot, Sorbonne Paris Cité, 5 place Jules Janssen, F-92195 Meudon (France); López Ariste, A. [IRAP—CNRS UMR 5277, 14, Av. E. Belin, F-31400 Toulouse (France); Dalmasse, K. [CISL/HAO, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000 (United States); Gelly, B., E-mail: p.levens.1@research.gla.ac.uk, E-mail: brigitte.schmieder@obspm.fr [CNRS UMR 3718 THEMIS, La Laguna, Tenerife (Spain)

    2016-08-01

    Spectropolarimetric observations of prominences have been obtained with the THEMIS telescope during four years of coordinated campaigns. Our aim is now to understand the conditions of the cool plasma and magnetism in “atypical” prominences, namely when the measured inclination of the magnetic field departs, to some extent, from the predominantly horizontal field found in “typical” prominences. What is the role of the magnetic field in these prominence types? Are plasma dynamics more important in these cases than the magnetic support? We focus our study on three types of “atypical” prominences (tornadoes, bubbles, and jet-like prominence eruptions) that have all been observed by THEMIS in the He i D{sub 3} line, from which the Stokes parameters can be derived. The magnetic field strength, inclination, and azimuth in each pixel are obtained by using the inversion method of principal component analysis on a model of single scattering in the presence of the Hanle effect. The magnetic field in tornadoes is found to be more or less horizontal, whereas for the eruptive prominence it is mostly vertical. We estimate a tendency toward higher values of magnetic field strength inside the bubbles than outside in the surrounding prominence. In all of the models in our database, only one magnetic field orientation is considered for each pixel. While sufficient for most of the main prominence body, this assumption appears to be oversimplified in atypical prominence structures. We should consider these observations as the result of superposition of multiple magnetic fields, possibly even with a turbulent field component.

  9. Secondary Structure of Rat and Human Amylin across Force Fields.

    Directory of Open Access Journals (Sweden)

    Kyle Quynn Hoffmann

    Full Text Available The aggregation of human amylin has been strongly implicated in the progression of Type II diabetes. This 37-residue peptide forms a variety of secondary structures, including random coils, α-helices, and β-hairpins. The balance between these structures depends on the chemical environment, making amylin an ideal candidate to examine inherent biases in force fields. Rat amylin differs from human amylin by only 6 residues; however, it does not form fibrils. Therefore it provides a useful complement to human amylin in studies of the key events along the aggregation pathway. In this work, the free energy of rat and human amylin was determined as a function of α-helix and β-hairpin content for the Gromos96 53a6, OPLS-AA/L, CHARMM22/CMAP, CHARMM22*, Amberff99sb*-ILDN, and Amberff03w force fields using advanced sampling techniques, specifically bias exchange metadynamics. This work represents a first systematic attempt to evaluate the conformations and the corresponding free energy of a large, clinically relevant disordered peptide in solution across force fields. The NMR chemical shifts of rIAPP were calculated for each of the force fields using their respective free energy maps, allowing us to quantitatively assess their predictions. We show that the predicted distribution of secondary structures is sensitive to the choice of force-field: Gromos53a6 is biased towards β-hairpins, while CHARMM22/CMAP predicts structures that are overly α-helical. OPLS-AA/L favors disordered structures. Amberff99sb*-ILDN, AmberFF03w and CHARMM22* provide the balance between secondary structures that is most consistent with available experimental data. In contrast to previous reports, our findings suggest that the equilibrium conformations of human and rat amylin are remarkably similar, but that subtle differences arise in transient alpha-helical and beta-strand containing structures that the human peptide can more readily adopt. We hypothesize that these transient

  10. Structure fields in the solidifying cast iron roll

    Directory of Open Access Journals (Sweden)

    W.S. Wołczyński

    2010-01-01

    Full Text Available Some properties of the rolls depend on the ratio of columnar structure area to equiaxed structure area created during roll solidification. The transition is fundamental phenomenon that can be apply to characterize massive cast iron rolls produced by the casting house. As the first step of simulation, a temperature field for solidifying cast iron roll was created. The convection in the liquid is not comprised since in the first approximation, the convection does not influence the studied occurrence of the (columnar to equiaxed grains transition in the roll. The obtained temperature field allows to study the dynamics of its behavior observed in the middle of the mould thickness. This midpoint of the mould thickness was treated as an operating point for the transition. A full accumulation of the heat in the mould was postulated for the transition. Thus, a plateau at the curve was observed at the midpoint. The range of the plateau existence corresponded to the incubation period , that appeared before fully equiaxed grains formation. At the second step of simulation, behavior of the thermal gradients field was studied. Three ranges within the filed were visible: EC→EC→EC→EC→(tTECtt↔RERCtt↔a/ for the formation of columnar structure (the C – zone: ( and 0>>T&0>>=−>−=REREttGttG.The columnar structure formation was significantly slowed down during incubation period. It resulted from a competition between columnar growth and equiaxed growth expected at that period of time. The 0≈=−=RERCttGttG relationship was postulated to correspond well with the critical thermal gradient, known in the Hunt’s theory. A simulation was performed for the cast iron rolls solidifying as if in industrial condition. Since the incubation divides the roll into two zones: C and E; (the first with columnar structure and the second with fully equiaxed structure some experiments dealing with solidification were made on semi-industrial scale.

  11. Life expectancy in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    OBJECTIVE: Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20 years. These calculations are based on data for individuals at the age of 15 years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later...... onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder. METHODS: Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we...... remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life-years during early and mid-adulthood. CONCLUSIONS: Life expectancy in bipolar disorder is decreased substantially, but less so than previously...

  12. Identifying early indicators in bipolar disorder: a qualitative study.

    Science.gov (United States)

    Benti, Liliane; Manicavasagar, Vijaya; Proudfoot, Judy; Parker, Gordon

    2014-06-01

    The identification of early markers has become a focus for early intervention in bipolar disorder. Using a retrospective, qualitative methodology, the present study compares the early experiences of participants with bipolar disorder to those with unipolar depression up until their first diagnosed episode. The study focuses on differences in early home and school environments as well as putative differences in personality characteristics between the two groups. Finally we a compare and contrast prodromal symptoms in these two populations. Thirty-nine participants, 20 diagnosed with unipolar depression and 19 diagnosed with bipolar disorder, took part in the study. A semi-structured interview was developed to elicit information about participants' experiences prior to their first episode. Participants with bipolar disorder reported disruptive home environments, driven personality features, greater emotion dysregulation and adverse experiences during the school years, whereas participants with depression tended to describe more supportive home environments, and more compliant and introvert personality traits. Retrospective data collection and no corroborative evidence from other family members. No distinction was made between bipolar I and bipolar II disorder nor between melancholic and non-melancholic depression in the sample. Finally the study spanned over a 12-month period which does not allow for the possibility of diagnostic reassignment of some of the bipolar participants to the unipolar condition. These findings indicate that there may be benefits in combining both proximal and distal indicators in identifying a bipolar disorder phenotype which, in turn, may be relevant to the development of early intervention programs for young people with bipolar disorder.

  13. Mean-field theory of nuclear structure and dynamics

    International Nuclear Information System (INIS)

    Negele, J.W.

    1982-01-01

    The physical and theoretical foundations are presented for the mean-field theory of nuclear structure and dynamics. Salient features of the many-body theory of stationary states are reviewed to motivate the time-dependent mean-field approximation. The time-dependent Hartree-Fock approximation and its limitations are discussed and general theoretical formulations are presented which yield time-dependent mean-field equations in lowest approximation and provide suitable frameworks for overcoming various conceptual and practical limitations of the mean-field theory. Particular emphasis is placed on recent developments utilizing functional integral techniques to obtain a quantum mean-field theory applicable to quantized eigenstates, spontaneous fission, the nuclear partition function, and scattering problems. Applications to a number of simple, idealized systems are presented to verify the approximations for solvable problems and to elucidate the essential features of mean-field dynamics. Finally, calculations utilizing moderately realistic geometries and interactions are reviewed which address heavy-ion collisions, fusion, strongly damped collisions, and fission

  14. MAGNETIC FIELD STRUCTURES TRIGGERING SOLAR FLARES AND CORONAL MASS EJECTIONS

    International Nuclear Information System (INIS)

    Kusano, K.; Bamba, Y.; Yamamoto, T. T.; Iida, Y.; Toriumi, S.; Asai, A.

    2012-01-01

    Solar flares and coronal mass ejections, the most catastrophic eruptions in our solar system, have been known to affect terrestrial environments and infrastructure. However, because their triggering mechanism is still not sufficiently understood, our capacity to predict the occurrence of solar eruptions and to forecast space weather is substantially hindered. Even though various models have been proposed to determine the onset of solar eruptions, the types of magnetic structures capable of triggering these eruptions are still unclear. In this study, we solved this problem by systematically surveying the nonlinear dynamics caused by a wide variety of magnetic structures in terms of three-dimensional magnetohydrodynamic simulations. As a result, we determined that two different types of small magnetic structures favor the onset of solar eruptions. These structures, which should appear near the magnetic polarity inversion line (PIL), include magnetic fluxes reversed to the potential component or the nonpotential component of major field on the PIL. In addition, we analyzed two large flares, the X-class flare on 2006 December 13 and the M-class flare on 2011 February 13, using imaging data provided by the Hinode satellite, and we demonstrated that they conform to the simulation predictions. These results suggest that forecasting of solar eruptions is possible with sophisticated observation of a solar magnetic field, although the lead time must be limited by the timescale of changes in the small magnetic structures.

  15. Electric Field Structures in Thin Films: Formation and Properties

    DEFF Research Database (Denmark)

    Cassidy, Andrew; Plekan, Oksana; Balog, Richard

    2014-01-01

    A newly discovered class of molecular materials, so-called “spontelectrics”, display spontaneous electric fields. Here we show that the novel properties of spontelectrics can be used to create composite spontelectrics, illustrating how electric fields in solid films may be structured on the nanoscale...... by combining layers of different spontelectric materials. This is demonstrated using the spontelectric materials nitrous oxide, toluene, isoprene, isopentane, and CF2Cl2. These yield a variety of tailored electric field structures, with individual layers harboring fields between 107 and 108 V/m. Fields may...

  16. The integrable structure of nonrational conformal field theory

    Energy Technology Data Exchange (ETDEWEB)

    Bytsko, A. [Steklov Mathematics Institute, St. Petersburg (Russian Federation); Teschner, J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2009-02-15

    Using the example of Liouville theory, we show how the separation into left- and rightmoving degrees of freedom of a nonrational conformal field theory can be made explicit in terms of its integrable structure. The key observation is that there exist separate Baxter Q-operators for left- and right-moving degrees of freedom. Combining a study of the analytic properties of the Q-operators with Sklyanin's Separation of Variables Method leads to a complete characterization of the spectrum. Taking the continuum limit allows us in particular to rederive the Liouville reflection amplitude using only the integrable structure. (orig.)

  17. [Bipolar disorder in adolescence].

    Science.gov (United States)

    Brunelle, Julie; Milhet, Vanessa; Consoli, Angèle; Cohen, David

    2014-04-01

    Juvenile mania is a concept widely developed but also highly debated since the 1990s. In the heart of this debate, Severe Mood Dysregulation (SMD) and "Temper Dysregulation disorder with Dysphoria" (recently integrated in DSM-5) showed their interest. Actually, the objective is to distinguish two clinical phenotypes in order to avoid confusion between (1) what would raise more of mood dysregulation with chronic manic like symptoms, and (2) bipolar disorder type I with episodic and acute manic episodes. Therapeutic stakes are major. In adolescents, even if DSM adult diagnostic criteria can be used and bipolar disorder type I clearly established, differential diagnostic at onset between acute manic episode and schizophrenia onset remain sometimes difficult to assess. Furthermore, it is crucial to better assess outcome of these adolescents, in terms of morbidity and potential prognosis factors, knowing that a younger age at onset is associated with a poorer outcome according to several adult studies. Therapeutic implications could then be drawn.

  18. Depressive and bipolar disorders

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hansen, Hanne Vibe; Demyttenaere, Koen

    2005-01-01

    of the patients (40-80%) had erroneous views as to the effect of antidepressants. Older patients (over 40 years of age) consistently had a more negative view of the doctor-patient relationship, more erroneous ideas concerning the effect of antidepressants and a more negative view of antidepressants in general....... Moreover, their partners agreed on these negative views. Women had a more negative view of the doctor-patient relationship than men, and patients with a depressive disorder had a more negative view of antidepressants than patients with bipolar disorder. The number of psychiatric hospitalizations......BACKGROUND: There is increasing evidence that attitudes and beliefs are important in predicting adherence to treatment and medication in depressive and bipolar disorders. However, these attitudes have received little study in patients whose disorders were sufficiently severe to require...

  19. Structures of conserved currents and mass spectra for scalar fields

    International Nuclear Information System (INIS)

    Shintani, Meiun.

    1979-05-01

    Considering the commutators between a scalar field and a conserved current, we shall clarify the connection between the mass spectrum for a scalar field and the structures of a current. For a special form of currents involving c-number functions, non-invariance of the vacuum under the corresponding transformation entails the existence of a massive mode. It is shown that once a type of currents is specified, the pole structures for sub(o) depend only on c-number parts of J sub(μ)(x). We shall show that non-vanishing Goldstone commutator does not automatically imply the degeneracy of the vacuum state, and discuss the applicability of the Goldstone theorem. (author)

  20. Bipolar Plates for PEM Systems

    OpenAIRE

    Lædre, Sigrid

    2016-01-01

    Summary of thesis: The Bipolar Plate (BPP) is an important component in both Proton Exchange Membrane Fuel Cells (PEMFCs) and Proton Exchange Membrane Water Electrolyzers (PEMWEs). Bipolar plate material and processing constitutes for a large fraction of the cost and weight of a PEM cell stack. The main tasks for the bipolar plates in both systems are to separate single cell in a stack, conduct current between single cells and remove heat from active areas. In addition, the BPPs distribu...

  1. Magnetic field structures in active compact radio sources

    International Nuclear Information System (INIS)

    Jones, T.W.; Rudnick, L.; Fiedler, R.L.; Aller, H.D.; Aller, M.F.; Hodge, P.E.

    1985-01-01

    The analysis of simultaneous multifrequency linear polarimetry data between 1.4 GHz and 90 GHz for about 20 active, compact radio sources at six epochs from 1977 December 10 1980 July is presented. In addition, monthly 8 Ghz polarization data on the same sources were examined. The general polarization characteristics of these sources can be well described in terms of magnetic fields which are largely turbulent and slightly anisotropic. The magnetic field symmetry axes are generally aligned with the source structural axes on the milli-arcsecond scale (OJ 287 is a notable exception.) Monte Carlo calculations indicate that observed polarization variations and in particular rotator polarization events can be produced in this model as a consequence of random walks generated through evolution of the turbulent magnetic field. 43 references

  2. Giant Magnetic Field Enhancement in Hybridized MIM Structures

    KAUST Repository

    Alrasheed, Salma

    2017-10-23

    We propose numerically an approach to narrow the plasmon linewidth and enhance the magnetic near field intensity at a magnetic hot spot in a hybridized metal-insulatormetal (MIM) structure. First we insert in part of the dielectric layer of the MIM, at its center, another dielectric material of a high refractive index (HRI). This results in an increase in the magnetic near field enhancement of the magnetic plasmon (MP) resonance by 82% compared with the MIM without the HRI material. We then couple this enhanced MP resonance to a propagating surface plasmon polariton (SPP) to achieve a further enhancement of 438%. The strong coupling between the MP and the SPP is demonstrated by the large anti-crossing in the reflection spectra. The resulting maximum magnetic field enhancement at the gap is ~ |H / Hi|² = 3555.

  3. The ontology of quantum field theory: Structural realism vindicated?

    Science.gov (United States)

    Glick, David

    2016-10-01

    In this paper I elicit a prediction from structural realism and compare it, not to a historical case, but to a contemporary scientific theory. If structural realism is correct, then we should expect physics to develop theories that fail to provide an ontology of the sort sought by traditional realists. If structure alone is responsible for instrumental success, we should expect surplus ontology to be eliminated. Quantum field theory (QFT) provides the framework for some of the best confirmed theories in science, but debates over its ontology are vexed. Rather than taking a stand on these matters, the structural realist can embrace QFT as an example of just the kind of theory SR should lead us to expect. Yet, it is not clear that QFT meets the structuralist's positive expectation by providing a structure for the world. In particular, the problem of unitarily inequivalent representations threatens to undermine the possibility of QFT providing a unique structure for the world. In response to this problem, I suggest that the structuralist should endorse pluralism about structure. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. [Creativity and bipolar disorder].

    Science.gov (United States)

    Maçkalı, Zeynep; Gülöksüz, Sinan; Oral, Timuçin

    2014-01-01

    The relationship between creativity and bipolar disorder has been an intriguing topic since ancient times. Early studies focused on describing characteristics of creative people. From the last quarter of the twentieth century, researchers began to focus on the relationship between mood disorders and creativity. Initially, the studies were based on biographical texts and the obtained results indicated a relationship between these two concepts. The limitations of the retrospective studies led the researchers to develop systematic investigations into this area. The systematic studies that have focused on artistic creativity have examined both the prevalence of mood disorders and the creative process. In addition, a group of researchers addressed the relationship in terms of affective temperaments. Through the end of the 90's, the scope of creativity was widened and the notion of everyday creativity was proposed. The emergence of this notion led researchers to investigate the associations of the creative process in ordinary (non-artist) individuals. In this review, the descriptions of creativity and creative process are mentioned. Also, the creative process is addressed with regards to bipolar disorder. Then, the relationship between creativity and bipolar disorder are evaluated in terms of aforementioned studies (biographical, systematic, psychobiographical, affective temperaments). In addition, a new model, the "Shared Vulnerability Model" which was developed to explain the relationship between creativity and psychopathology is introduced. Finally, the methodological limitations and the suggestions for resolving these limitations are included.

  5. Reviewing metallic PEMFC bipolar plates

    Energy Technology Data Exchange (ETDEWEB)

    Wang, H.; Turner, J.A. [National Renewable Energy Laboratory, Golden, CO (United States)

    2010-08-15

    A bipolar plate is one of the most important components in a polymer exchange membrane fuel cell (PEMFC) stack and has multiple functions. Metallic bipolar plate candidates have advantages over composite rivals in excellent electrical and thermal conductivity, good mechanical strength, high chemical stability, very wide alloy choices, low cost and, most importantly, existing pathways for high-volume, high-speed mass production. The challenges with metallic bipolar plates are the higher contact resistance and possible corrosion products, which may contaminate the membrane electrode assembly. This review evaluates the candidate metallic and coating materials for bipolar plates and gives the perspective of the research trends. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  6. STRUCTURE OF PROMINENCE LEGS: PLASMA AND MAGNETIC FIELD

    Energy Technology Data Exchange (ETDEWEB)

    Levens, P. J.; Labrosse, N. [SUPA School of Physics and Astronomy, University of Glasgow, Glasgow, G12 8QQ (United Kingdom); Schmieder, B. [Observatoire de Paris, Meudon, F-92195 (France); Ariste, A. López, E-mail: p.levens.1@research.gla.ac.uk [Institut de Recherche en Astrophysique et Planétologie, Toulouse (France)

    2016-02-10

    We investigate the properties of a “solar tornado” observed on 2014 July 15, and aim to link the behavior of the plasma to the internal magnetic field structure of the associated prominence. We made multi-wavelength observations with high spatial resolution and high cadence using SDO/AIA, the Interface Region Imaging Spectrograph (IRIS) spectrograph, and the Hinode/Solar Optical Telescope (SOT) instrument. Along with spectropolarimetry provided by the Télescope Héliographique pour l’Etude du Magnétisme et des Instabilités Solaires telescope we have coverage of both optically thick emission lines and magnetic field information. AIA reveals that the two legs of the prominence are strongly absorbing structures which look like they are rotating, or oscillating in the plane of the sky. The two prominence legs, which are both very bright in Ca ii (SOT), are not visible in the IRIS Mg ii slit-jaw images. This is explained by the large optical thickness of the structures in Mg ii, which leads to reversed profiles, and hence to lower integrated intensities at these locations than in the surroundings. Using lines formed at temperatures lower than 1 MK, we measure relatively low Doppler shifts on the order of ±10 km s{sup −1} in the tornado-like structure. Between the two legs we see loops in Mg ii, with material flowing from one leg to the other, as well as counterstreaming. It is difficult to interpret our data as showing two rotating, vertical structures that are unrelated to the loops. This kind of “tornado” scenario does not fit with our observations. The magnetic field in the two legs of the prominence is found to be preferentially horizontal.

  7. Self-Referential Thinking, Suicide, and Function of the Cortical Midline Structures and Striatum in Mood Disorders: Possible Implications for Treatment Studies of Mindfulness-Based Interventions for Bipolar Depression

    Directory of Open Access Journals (Sweden)

    William R. Marchand

    2012-01-01

    Full Text Available Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking with functional imaging of CMS and striatal function may help delineate the neurobiological mechanisms of action of these treatments.

  8. Field theoretic approach to structure formation in an anisotropic medium

    International Nuclear Information System (INIS)

    Joy, Minu; Kuriakose, V.C.

    2003-01-01

    Considering a real scalar field distribution which is assumed to be locally anisotropic and coupled to a Bianchi type-I background spacetime, the energy density and pressure associated with the anisotropic matter field distribution are evaluated. The vanishing of the expectation values of the nondiagonal components of T μν allows us to treat the scalar field in complete analogy with the distribution of fluid. The primeval density perturbations produced by the vacuum fluctuations of the scalar field are considered and the Jeans criterion for structure formation is obtained. The metric and matter field perturbations are considered and it is found that for the present anisotropic case the perturbations of the pressure in the radial and tangential directions are different. The Jeans instability is discussed and the Jeans wave number for the present case is evaluated. It is found that for the anisotropic case the Jeans length depends on the velocity of the fluctuations in the radial and transverse directions and thus on the direction of propagation of the perturbations

  9. Structure and evolution of magnetic fields associated with solar eruptions

    International Nuclear Information System (INIS)

    Wang Haimin; Liu Chang

    2015-01-01

    This paper reviews the studies of solar photospheric magnetic field evolution in active regions and its relationship to solar flares. It is divided into two topics, the magnetic structure and evolution leading to solar eruptions and rapid changes in the photospheric magnetic field associated with eruptions. For the first topic, we describe the magnetic complexity, new flux emergence, flux cancelation, shear motions, sunspot rotation and magnetic helicity injection, which may all contribute to the storage and buildup of energy that trigger solar eruptions. For the second topic, we concentrate on the observations of rapid and irreversible changes of the photospheric magnetic field associated with flares, and the implication on the restructuring of the three-dimensional magnetic field. In particular, we emphasize the recent advances in observations of the photospheric magnetic field, as state-of-the-art observing facilities (such as Hinode and Solar Dynamics Observatory) have become available. The linkages between observations, theories and future prospectives in this research area are also discussed. (invited reviews)

  10. Magnetic field effects on the crust structure of neutron stars

    Science.gov (United States)

    Franzon, B.; Negreiros, R.; Schramm, S.

    2017-12-01

    We study the effects of high magnetic fields on the structure and on the geometry of the crust in neutron stars. We find that the crust geometry is substantially modified by the magnetic field inside the star. We build stationary and axis-symmetric magnetized stellar models by using well-known equations of state to describe the neutron star crust, namely, the Skyrme model for the inner crust and the Baym-Pethick-Sutherland equation of state for the outer crust. We show that the magnetic field has a dual role, contributing to the crust deformation via the electromagnetic interaction (manifested in this case as the Lorentz force) and by contributing to curvature due to the energy stored in it. We also study a direct consequence of the crust deformation due to the magnetic field: the thermal relaxation time. This quantity, which is of great importance to the thermal evolution of neutron stars, is sensitive to the crust properties, and, as such, we show that it may be strongly affected by the magnetic field.

  11. Ab initio protein structure assembly using continuous structure fragments and optimized knowledge-based force field.

    Science.gov (United States)

    Xu, Dong; Zhang, Yang

    2012-07-01

    Ab initio protein folding is one of the major unsolved problems in computational biology owing to the difficulties in force field design and conformational search. We developed a novel program, QUARK, for template-free protein structure prediction. Query sequences are first broken into fragments of 1-20 residues where multiple fragment structures are retrieved at each position from unrelated experimental structures. Full-length structure models are then assembled from fragments using replica-exchange Monte Carlo simulations, which are guided by a composite knowledge-based force field. A number of novel energy terms and Monte Carlo movements are introduced and the particular contributions to enhancing the efficiency of both force field and search engine are analyzed in detail. QUARK prediction procedure is depicted and tested on the structure modeling of 145 nonhomologous proteins. Although no global templates are used and all fragments from experimental structures with template modeling score >0.5 are excluded, QUARK can successfully construct 3D models of correct folds in one-third cases of short proteins up to 100 residues. In the ninth community-wide Critical Assessment of protein Structure Prediction experiment, QUARK server outperformed the second and third best servers by 18 and 47% based on the cumulative Z-score of global distance test-total scores in the FM category. Although ab initio protein folding remains a significant challenge, these data demonstrate new progress toward the solution of the most important problem in the field. Copyright © 2012 Wiley Periodicals, Inc.

  12. Scanning near-field infrared microscopy on semiconductor structures

    Energy Technology Data Exchange (ETDEWEB)

    Jacob, Rainer

    2011-01-15

    literature. While the structures of the first system were in the micrometer regime, the capability to probe buried nanostructures is demonstrated at a sample of indium arsenide quantum dots. Those dots are covered by a thick layer of gallium arsenide. For the first time ever, it is shown experimentally that transitions between electron states in single quantum dots can be investigated by near-field microscopy. By monitoring the near-field response of these quantum dots while scanning the wavelength of the incident light beam, it was possible to obtain characteristic near-field signatures of single dots. Near-field contrasts up to 30 % could be measured for resonant excitation of electrons in the conduction band of the indium arsenide dots. (orig.)

  13. Scanning near-field infrared microscopy on semiconductor structures

    International Nuclear Information System (INIS)

    Jacob, Rainer

    2011-01-01

    literature. While the structures of the first system were in the micrometer regime, the capability to probe buried nanostructures is demonstrated at a sample of indium arsenide quantum dots. Those dots are covered by a thick layer of gallium arsenide. For the first time ever, it is shown experimentally that transitions between electron states in single quantum dots can be investigated by near-field microscopy. By monitoring the near-field response of these quantum dots while scanning the wavelength of the incident light beam, it was possible to obtain characteristic near-field signatures of single dots. Near-field contrasts up to 30 % could be measured for resonant excitation of electrons in the conduction band of the indium arsenide dots. (orig.)

  14. Turbulent flow field structure of initially asymmetric jets

    International Nuclear Information System (INIS)

    Kim, Kyung Hoon; Kim, Bong Whan; Kim, Suk Woo

    2000-01-01

    The near field structure of round turbulent jets with initially asymmetric velocity distributions is investigated experimentally. Experiments are carried out using a constant temperature hot-wire anemomentry system to measure streamwise velocity in the jets. The measurements are undertaken across the jet at various streamwise stations in a range starting from the jet exit plane and up to a downstream location of twelve diameters. The experimental results include the distributions of mean and instantaneous velocities, vorticity field, turbulence intensity, and the Reynolds shear stresses. The asymmetry of the jet exit plane was obtained by using circular cross-section pipes with a bend upstream of the exit. Three pipes used here include a straight pipe, and 90 and 160 degree-bend pipes. Therefore, at the upstream of the pipe exit, secondary flow through the bend and mean streamwise velocity distribution could be controlled by changing the curvature of pipes. The jets into the atmosphere have two levels of initial velocity skewness in addition to an axisymmetric jet from a straight pipe. In case of the curved pipe, a six diameterlong straight pipe section follows the bend upstream of the exit. The Reynolds number based on the exit bulk velocity is 13,400. The results indicate that the near field structure is considerably modified by the skewness of an initial mean velocity distribution. As the skewness increases, the decay rate of mean velocity at the centerline also increases

  15. Structural analysis of the NET toroidal field coils and conductor

    International Nuclear Information System (INIS)

    Mitchell, N.; Collier, D.; Gori, R.

    1989-01-01

    The NET toroidal field coils will utilise A15-type superconductor at 4.2 K to generate fields up to 11.5 T. The superconductor strands themselves are sensitive to strain, which causes degradation of their current carrying capacity, and thus the detailed behaviour of the coil conductor must be analysied so that the strian can be minimised. This analysis must include the manufacturing processes of the conductor as well as the normal and abnormal loperational loads. The conductor will be insulated and bonded by glass fibre reinforced epoxy resin, with limited bonding shear strength, and the overall support of the complete coil system must be designed to reduce these shear stresses. The coils will be subjected to pulse loads form the poloidal field coils, and analysis of the slip between the various coil components, such as conductors and the coil case, giving rise to frictional heating and possible loss of superconducting properties is another important factor, which has been investigated by a number of stress analyses. The manufacturing, thermal and normal magnetic loads on the coils and the analysis leading to the proposed structural design are described. In addition to the normal operating conditions, there is a range of abnormal load conditions which could result from electrical or mechanical faults on the coils. The effect of these potential faults has been analysed and the coil design modified to prevent catastrophic structural failure. (author). 13 refs.; 8 figs.; 1 tab

  16. Generation of metal composition gradients by means of bipolar electrodeposition

    International Nuclear Information System (INIS)

    Tisserant, Gwendoline; Fattah, Zahra; Ayela, Cédric; Roche, Jérome; Plano, Bernard; Zigah, Dodzi; Goudeau, Bertrand; Kuhn, Alexander; Bouffier, Laurent

    2015-01-01

    Highlights: • A bipolar electrochemistry approach for the preparation of surface gradients is reported. • Several metals are simultaneously deposited on a bipolar electrode. • The elemental composition and thickness of the deposit varies alongside the bipolar electrode. • The deposit affects the surface properties and exhibits a barcode feature. - Abstract: Bipolar electrochemistry is an unconventional technique that currently encounters a renewal of interest due to modern applications in the fields of analytical chemistry or materials science. The approach is particularly relevant for the preparation of asymmetric objects or surfaces such as Janus particles for example. Bipolar electrochemistry allows spatially controlled deposition of various layers from electroactive precursors, selectively at one side of a bipolar electrode. We report here the concomitant cathodic deposition of up to three different metals at the same time in a single experiment. The deposits were characterized by optical and electron microscopy imaging as well as profilometry and energy dispersive X-ray spectroscopy. As a result, the deposited layer is composed of several areas exhibiting both a composition and a thickness gradient. Such a variation directly modifies the optical and electronic properties alongside the surface and gives access to the design of composite surfaces exhibiting a visual gradient feature.

  17. Filament shape versus coronal potential magnetic field structure

    Science.gov (United States)

    Filippov, B.

    2016-01-01

    Solar filament shape in projection on disc depends on the structure of the coronal magnetic field. We calculate the position of polarity inversion lines (PILs) of coronal potential magnetic field at different heights above the photosphere, which compose the magnetic neutral surface, and compare with them the distribution of the filament material in Hα chromospheric images. We found that the most of the filament material is enclosed between two PILs, one at a lower height close to the chromosphere and one at a higher level, which can be considered as a height of the filament spine. Observations of the same filament on the limb by the Solar Terrestrial Relations Observatory spacecraft confirm that the height of the spine is really very close to the value obtained from the PIL and filament border matching. Such matching can be used for filament height estimations in on-disc observations. Filament barbs are housed within protruding sections of the low-level PIL. On the base of simple model, we show that the similarity of the neutral surfaces in potential and non-potential fields with the same sub-photospheric sources is the reason for the found tendency for the filament material to gather near the potential-field neutral surface.

  18. Photo field emission spectroscopy of the tantalum band structure

    International Nuclear Information System (INIS)

    Kleint, Ch.; Radon, T.

    1978-01-01

    Photo field emission (PFE) currents of clean and barium covered tantalum tips have been measured with single lines of the mercury arc spectrum and phase-sensitive detection. Field strength and work function were determined from Fowler-Nordheim plots of the FE currents. Shoulders in the PFE current-voltage characteristics could be correlated to transitions in the band structure of tantalum according to a recently proposed two-step PFE model. A comparison with the relativistic calculations of Mattheiss and the nonrelativistic bands of Petroff and Viswanathan shows that Mattheiss' bands are more appropriate. Beside direct transitions several nondirect transitions from the different features composing the upper two density of states maxima below the Fermi edge of tantalum have been found. (Auth.)

  19. Magnetic field adjustment structure and method for a tapered wiggler

    Science.gov (United States)

    Halbach, Klaus

    1988-01-01

    An improved method and structure is disclosed for adjusting the magnetic field generated by a group of electromagnet poles spaced along the path of a charged particle beam to compensate for energy losses in the charged particles which comprises providing more than one winding on at least some of the electromagnet poles; connecting one respective winding on each of several consecutive adjacent electromagnet poles to a first power supply, and the other respective winding on the electromagnet pole to a different power supply in staggered order; and independently adjusting one power supply to independently vary the current in one winding on each electromagnet pole in a group whereby the magnetic field strength of each of a group of electromagnet poles may be changed in smaller increments.

  20. Epidemiology in Pediatric Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Caner Mutlu

    2015-12-01

    Full Text Available Childhood and adolescent bipolar disorder diagnosis has been increasing recently. Since studies evaluating attempted suicide rates in children and adolescents have shown bipolarity to be a significant risk factor, diagnosis and treatment of bipolarity has become a very important issue. Since there is a lack of specific diagnostic criteria for especially preadolescent samples and evaluations are made mostly symptomatically, suspicions about false true diagnosis and increased prevalence rates have emerged. This situation leads to controversial data about the prevalence rates of bipolar disorder in children and adolescents. The aim of this article is to review the prevalence of childhood and adolescent bipolar disorder in community, inpatient and outpatient based samples in literature.

  1. Early Intervention in Bipolar Disorder.

    Science.gov (United States)

    Vieta, Eduard; Salagre, Estela; Grande, Iria; Carvalho, André F; Fernandes, Brisa S; Berk, Michael; Birmaher, Boris; Tohen, Mauricio; Suppes, Trisha

    2018-05-01

    Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and usually has its onset during youth. Its chronic course is associated with high rates of morbidity and mortality, making bipolar disorder one of the main causes of disability among young and working-age people. The implementation of early intervention strategies may help to change the outcome of the illness and avert potentially irreversible harm to patients with bipolar disorder, as early phases may be more responsive to treatment and may need less aggressive therapies. Early intervention in bipolar disorder is gaining momentum. Current evidence emerging from longitudinal studies indicates that parental early-onset bipolar disorder is the most consistent risk factor for bipolar disorder. Longitudinal studies also indicate that a full-blown manic episode is often preceded by a variety of prodromal symptoms, particularly subsyndromal manic symptoms, therefore supporting the existence of an at-risk state in bipolar disorder that could be targeted through early intervention. There are also identifiable risk factors that influence the course of bipolar disorder, some of them potentially modifiable. Valid biomarkers or diagnosis tools to help clinicians identify individuals at high risk of conversion to bipolar disorder are still lacking, although there are some promising early results. Pending more solid evidence on the best treatment strategy in early phases of bipolar disorder, physicians should carefully weigh the risks and benefits of each intervention. Further studies will provide the evidence needed to finish shaping the concept of early intervention. AJP AT 175 Remembering Our Past As We Envision Our Future April 1925: Interpretations of Manic-Depressive Phases Earl Bond and G.E. Partridge reviewed a number of patients with manic-depressive illness in search of a unifying endo-psychic conflict. They concluded that understanding either phase of illness was "elusive" and

  2. Novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs

    OpenAIRE

    Muhammad, Akram; Musavarah, Sarwar

    2016-01-01

    In this research study, we introduce the concept of bipolar neutrosophic graphs. We present the dominating and independent sets of bipolar neutrosophic graphs. We describe novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs. We also develop an algorithm for computing domination in bipolar neutrosophic graphs.

  3. The functional neuroanatomy of bipolar disorder: a consensus model

    Science.gov (United States)

    Strakowski, Stephen M; Adler, Caleb M; Almeida, Jorge; Altshuler, Lori L; Blumberg, Hilary P; Chang, Kiki D; DelBello, Melissa P; Frangou, Sophia; McIntosh, Andrew; Phillips, Mary L; Sussman, Jessika E; Townsend, Jennifer D

    2013-01-01

    Objectives Functional neuroimaging methods have proliferated in recent years, such that functional magnetic resonance imaging, in particular, is now widely used to study bipolar disorder. However, discrepant findings are common. A workgroup was organized by the Department of Psychiatry, University of Cincinnati (Cincinnati, OH, USA) to develop a consensus functional neuroanatomic model of bipolar I disorder based upon the participants’ work as well as that of others. Methods Representatives from several leading bipolar disorder neuroimaging groups were organized to present an overview of their areas of expertise as well as focused reviews of existing data. The workgroup then developed a consensus model of the functional neuroanatomy of bipolar disorder based upon these data. Results Among the participants, a general consensus emerged that bipolar I disorder arises from abnormalities in the structure and function of key emotional control networks in the human brain. Namely, disruption in early development (e.g., white matter connectivity, prefrontal pruning) within brain networks that modulate emotional behavior leads to decreased connectivity among ventral prefrontal networks and limbic brain regions, especially amygdala. This developmental failure to establish healthy ventral prefrontal–limbic modulation underlies the onset of mania and ultimately, with progressive changes throughout these networks over time and with affective episodes, a bipolar course of illness. Conclusions This model provides a potential substrate to guide future investigations and areas needing additional focus are identified. PMID:22631617

  4. Filamentary structure and magnetic field orientation in Musca

    Science.gov (United States)

    Cox, N. L. J.; Arzoumanian, D.; André, Ph.; Rygl, K. L. J.; Prusti, T.; Men'shchikov, A.; Royer, P.; Kóspál, Á.; Palmeirim, P.; Ribas, A.; Könyves, V.; Bernard, J.-Ph.; Schneider, N.; Bontemps, S.; Merin, B.; Vavrek, R.; Alves de Oliveira, C.; Didelon, P.; Pilbratt, G. L.; Waelkens, C.

    2016-05-01

    Herschel has shown that filamentary structures are ubiquitous in star-forming regions, in particular in nearby molecular clouds associated with Gould's Belt. High dynamic range far-infrared imaging of the Musca cloud with SPIRE and PACS reveals at least two types of filamentary structures: (1) the main ~10-pc scale high column-density linear filament; and (2) low column-density striations in close proximity to the main filament. In addition, we find features with intermediate column densities (hair-like strands) that appear physically connected to the main filament. We present an analysis of this filamentary network traced by Herschel and explore its connection with the local magnetic field. We find that both the faint dust emission striations and the plane-of-the-sky (POS) magnetic field are locally oriented close to perpendicular to the high-density main filament (position angle ~25-35°). The low-density striations and strands are oriented parallel to the POS magnetic field lines, which are derived previously from optical polarization measurements of background stars and more recently from Planck observations of dust polarized emission. The position angles are 97 ± 25°, 105 ± 7°, and 105 ± 5°. From these observations, we propose a scenario in which local interstellar material in this cloud has condensed into a gravitationally-unstable filament (with "supercritical" mass per unit length) that is accreting background matter along field lines through the striations. We also compare the filamentary structure in Musca with what is seen in similar Herschel observations of the Taurus B211/3 filament system and find that there is significantly less substructure in the Musca main filament than in the B211/3 filament. We suggest that the Musca cloud may represent an earlier evolutionary stage in which the main filament has not yet accreted sufficient mass and energy to develop a multiple system of intertwined filamentary components. Herschel is an ESA space

  5. Magnetic field structure of experimental high beta tokamak equilibria

    International Nuclear Information System (INIS)

    Deniz, A.V.

    1986-01-01

    The magnetic field structure of several low and high β tokamaks in the Columbia High Beta Tokamak (HBT) was determined by high-impedance internal magnetic probes. From the measurement of the magnetic field, the poloidal flux, toroidal flux, toroidal current, and safety factor are calculated. In addition, the plasma position and cross-sectional shape are determined. The extent of the perturbation of the plasma by the probe was investigated and was found to be acceptably small. The tokamaks have major radii of approx.0.24 m, minor radii of approx.0.05 m, toroidal plasma current densities of approx.10 6 A/m 2 , and line-integrated electron densities of approx.10 20 m -2 . The major difference between the low and high β tokamaks is that the high β tokamak was observed to have an outward shift in major radius of both the magnetic center and peak of the toroidal current density. The magnetic center moves inward in major radius after 20 to 30 μsec, presumably because the plasma maintains major radial equilibrium as its pressure decreases from radiation due to impurity atoms. Both the equilibrium and the production of these tokamaks from a toroidal field stabilized z-pinch are modeled computationally. One tokamak evolves from a state with low β features, through a possibly unstable state, to a state with high β features

  6. Characterization of ionizing radiation effects in MOS structures by study of bipolar operation; Caracterisation des effets induits par irradiations ionisantes dans des structures MOS a partir de leur fonctionnement en regime bipolaire

    Energy Technology Data Exchange (ETDEWEB)

    Bakhtiar, H. [Univ. Teknologi Malaysia, Dept. of Physics, Johor (Malaysia); Picard, C.; Brisset, C. [CEA Saclay, Lab. d' Electronique et de Technologie de l' Informatique, LETI, 91 - Gif-sur-Yvette (France); Bakhtiar, H.; Hoffmann, A.; Charles, J.P. [Metz Univ., LICM-CLOES-Supelec, 57 (France)

    1999-07-01

    This work presents an original method to characterize radiation effects of micronic transistors. The characterization includes a study of the transistor substrate-drain junction and current gain variation of the bipolar transistor (drain-substrate-source as emitter-base-collector) for different gate voltages. (author000.

  7. Bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2008-10-21

    A bipolar pulse forming transmission line module for linear induction accelerators having first, second, third, fourth, and fifth planar conductors which form an interleaved stack with dielectric layers between the conductors. Each conductor has a first end, and a second end adjacent an acceleration axis. The first and second planar conductors are connected to each other at the second ends, the fourth and fifth planar conductors are connected to each other at the second ends, and the first and fifth planar conductors are connected to each other at the first ends via a shorting plate adjacent the first ends. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short a high voltage from the first end of the third planar conductor to the first end of the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  8. Radio polarization and magnetic field structure in M 101

    Science.gov (United States)

    Berkhuijsen, E. M.; Urbanik, M.; Beck, R.; Han, J. L.

    2016-04-01

    We observed total and polarized radio continuum emission from the spiral galaxy M 101 at λλ 6.2 cm and 11.1 cm with the Effelsberg telescope. The angular resolutions are 2.´ 5 (=5.4 kpc) and 4.´ 4 (=9.5 kpc), respectively. We use these data to study various emission components in M 101 and properties of the magnetic field. Separation of thermal and non-thermal emission shows that the thermal emission is closely correlated with the spiral arms, while the non-thermal emission is more smoothly distributed indicating diffusion of cosmic ray electrons away from their places of origin. The radial distribution of both emissions has a break near R = 16 kpc (=7.´ 4), where it steepens to an exponential scale length of L ≃ 5 kpc, which is about 2.5 times smaller than at Rchange in the structure of M 101 takes place, which also affects the distributions of the strength of the random and ordered magnetic field. Beyond R = 16 kpc the radial scale length of both fields is about 20 kpc, which implies that they decrease to about 0.3 μG at R = 70 kpc, which is the largest optical extent. The equipartition strength of the total field ranges from nearly 10 μG at Rmechanism. We show that energetic events causing H I shells of mean diameter pitch angles that are about 8° larger than those of H I filaments. Based on observations with the 100 m telescope of the MPIfR at Effelsberg.FITS files of the images are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/588/A114

  9. Variations in soil microbial community structure induced by the conversion from paddy fields to upland fields

    Science.gov (United States)

    Dai, X.

    2015-12-01

    Land-use conversion is an important factor influencing the carbon and nitrogen gas exchange between land and atmosphere, and soil microorganisms is main driver of soil carbon and nitrogen gas production. Understanding the effect of land-use conversion on soil microbial communities and its influencing factor is important for greenhouse gas emission reduction and soil organic carbon and nitrogen sequestration and stability. The influence of land use conversion on soil process was undergoing a dynamic change, but little research has been done to understand the effect on soil microbial communities during the initial years after land conversion. In the study, the influences of land-use conversion from double rice cropping (RR) to maize-maize (MM) and soybean-peanut (SP) double cropping systems on soil physical and chemical properties, and microbial community structure was studied after two years of the conversion in southern China. The results showed that land use conversion significantly changed soil properties, microbial communities and biomass. Soil pH significantly decreased by 0.50 and 0.52 after conversion to MM and SP, respectively. Soil TN and NH4-N also significantly decreased by 9%-15% and 60% after conversion to upland fields, respectively. The total PLFAs, bacterial, gram-positive bacterial (G+), gram-negative bacterial (G-) and actinomycetic PLFAs decreased significantly. The ng g-1 soil concentration of monounsaturated chain PLFAs 16:1ω7c and 18:1ω9t were significantly higher at paddy fields than at upland fields. No significant differences in soil properties, microbial communities and biomass were found between conversed MM and SP. Our results indicated that land use conversion, not crop type conversed had a significant effects on soil properties and microbial communities at the initial of land conversion. And soil pH was the key factor regulating the variations in soil microbial community structure after land use conversion from paddy to upland fields.

  10. Conditional Random Fields for Pattern Recognition Applied to Structured Data

    Directory of Open Access Journals (Sweden)

    Tom Burr

    2015-07-01

    Full Text Available Pattern recognition uses measurements from an input domain, X, to predict their labels from an output domain, Y. Image analysis is one setting where one might want to infer whether a pixel patch contains an object that is “manmade” (such as a building or “natural” (such as a tree. Suppose the label for a pixel patch is “manmade”; if the label for a nearby pixel patch is then more likely to be “manmade” there is structure in the output domain that can be exploited to improve pattern recognition performance. Modeling P(X is difficult because features between parts of the model are often correlated. Therefore, conditional random fields (CRFs model structured data using the conditional distribution P(Y|X = x, without specifying a model for P(X, and are well suited for applications with dependent features. This paper has two parts. First, we overview CRFs and their application to pattern recognition in structured problems. Our primary examples are image analysis applications in which there is dependence among samples (pixel patches in the output domain. Second, we identify research topics and present numerical examples.

  11. Quantum field theory on toroidal topology: Algebraic structure and applications

    Energy Technology Data Exchange (ETDEWEB)

    Khanna, F.C., E-mail: khannaf@uvic.ca [Department of Physics and Astronomy, University of Victoria, Victoria, BC V8P 5C2 (Canada); TRIUMF, Vancouver, BC, V6T 2A3 (Canada); Malbouisson, A.P.C., E-mail: adolfo@cbpf.br [Centro Brasileiro de Pesquisas Físicas/MCT, 22290-180, Rio de Janeiro, RJ (Brazil); Malbouisson, J.M.C., E-mail: jmalboui@ufba.br [Instituto de Física, Universidade Federal da Bahia, 40210-340, Salvador, BA (Brazil); Santana, A.E., E-mail: asantana@unb.br [International Center for Condensed Matter Physics, Instituto de Física, Universidade de Brasília, 70910-900, Brasília, DF (Brazil)

    2014-06-01

    The development of quantum theory on a torus has a long history, and can be traced back to the 1920s, with the attempts by Nordström, Kaluza and Klein to define a fourth spatial dimension with a finite size, being curved in the form of a torus, such that Einstein and Maxwell equations would be unified. Many developments were carried out considering cosmological problems in association with particle physics, leading to methods that are useful for areas of physics, in which size effects play an important role. This interest in finite size effect systems has been increasing rapidly over the last decades, due principally to experimental improvements. In this review, the foundations of compactified quantum field theory on a torus are presented in a unified way, in order to consider applications in particle and condensed matter physics. The theory on a torus Γ{sub D}{sup d}=(S{sup 1}){sup d}×R{sup D−d} is developed from a Lie-group representation and c{sup ∗}-algebra formalisms. As a first application, the quantum field theory at finite temperature, in its real- and imaginary-time versions, is addressed by focusing on its topological structure, the torus Γ{sub 4}{sup 1}. The toroidal quantum-field theory provides the basis for a consistent approach of spontaneous symmetry breaking driven by both temperature and spatial boundaries. Then the superconductivity in films, wires and grains are analyzed, leading to some results that are comparable with experiments. The Casimir effect is studied taking the electromagnetic and Dirac fields on a torus. In this case, the method of analysis is based on a generalized Bogoliubov transformation, that separates the Green function into two parts: one is associated with the empty space–time, while the other describes the impact of compactification. This provides a natural procedure for calculating the renormalized energy–momentum tensor. Self interacting four-fermion systems, described by the Gross–Neveu and Nambu

  12. Quantum field theory on toroidal topology: Algebraic structure and applications

    International Nuclear Information System (INIS)

    Khanna, F.C.; Malbouisson, A.P.C.; Malbouisson, J.M.C.; Santana, A.E.

    2014-01-01

    The development of quantum theory on a torus has a long history, and can be traced back to the 1920s, with the attempts by Nordström, Kaluza and Klein to define a fourth spatial dimension with a finite size, being curved in the form of a torus, such that Einstein and Maxwell equations would be unified. Many developments were carried out considering cosmological problems in association with particle physics, leading to methods that are useful for areas of physics, in which size effects play an important role. This interest in finite size effect systems has been increasing rapidly over the last decades, due principally to experimental improvements. In this review, the foundations of compactified quantum field theory on a torus are presented in a unified way, in order to consider applications in particle and condensed matter physics. The theory on a torus Γ D d =(S 1 ) d ×R D−d is developed from a Lie-group representation and c ∗ -algebra formalisms. As a first application, the quantum field theory at finite temperature, in its real- and imaginary-time versions, is addressed by focusing on its topological structure, the torus Γ 4 1 . The toroidal quantum-field theory provides the basis for a consistent approach of spontaneous symmetry breaking driven by both temperature and spatial boundaries. Then the superconductivity in films, wires and grains are analyzed, leading to some results that are comparable with experiments. The Casimir effect is studied taking the electromagnetic and Dirac fields on a torus. In this case, the method of analysis is based on a generalized Bogoliubov transformation, that separates the Green function into two parts: one is associated with the empty space–time, while the other describes the impact of compactification. This provides a natural procedure for calculating the renormalized energy–momentum tensor. Self interacting four-fermion systems, described by the Gross–Neveu and Nambu–Jona-Lasinio models, are considered. Then

  13. Prevalences of autoimmune diseases in schizophrenia, bipolar I and II disorder, and controls.

    Science.gov (United States)

    Cremaschi, Laura; Kardell, Mathias; Johansson, Viktoria; Isgren, Anniella; Sellgren, Carl M; Altamura, A Carlo; Hultman, Christina M; Landén, Mikael

    2017-12-01

    Previous studies on the relationship between autoimmune diseases, schizophrenia, and bipolar disorder are mainly based on hospital discharge registers with insufficient coverage of outpatient data. Furthermore, data is scant on the prevalence of autoimmune diseases in bipolar subgroups. Here we estimate the self-reported prevalences of autoimmune diseases in schizophrenia, bipolar disorder type I and II, and controls. Lifetime prevalence of autoimmune diseases was assessed through a structured interview in a sample of 9076 patients (schizophrenia N = 5278, bipolar disorder type I N = 1952, type II N = 1846) and 6485 controls. Comparative analyses were performed using logistic regressions. The prevalence of diabetes type 1 did not differ between groups. Hyperthyroidism, hypothyroidism regardless of lithium effects, rheumatoid arthritis, and polymyalgia rheumatica were most common in bipolar disorder. Systemic lupus erythematosus was less common in bipolar disorder than in the other groups. The rate of autoimmune diseases did not differ significantly between bipolar subgroups. We conclude that prevalences of autoimmune diseases show clear differences between schizophrenia and bipolar disorder, but not between the bipolar subgroups. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. Bipolar disorder and the risk of fracture: A nationwide population-based cohort study.

    Science.gov (United States)

    Su, Jian-An; Cheng, Bi-Hua; Huang, Yin-Cheng; Lee, Chuan-Pin; Yang, Yao-Hsu; Lu, Mong-Liang; Hsu, Chung-Yao; Lee, Yena; McIntyre, Roger S; Chin Lin, Tzu; Chin-Hung Chen, Vincent

    2017-08-15

    The co-primary aims are: 1) to compare the risk of fracture between adults with bipolar disorder and those without bipolar disorder; and 2) to assess whether lithium, anticonvulsants and antipsychotics reduce risk of fracture among individuals with bipolar disorder. The analysis herein is a population-based retrospective cohort study, utilizing the National Health Insurance (NHI) medical claims data collected between 1997 and 2013 in Taiwan. We identified 3705 cases with incident diagnoses of bipolar disorder during study period and 37,050 matched controls without bipolar diagnoses. Incident diagnosis of fracture was operationalized as any bone fracture after the diagnosis of bipolar disorder or after the matched index date for controls. Bipolar patients had significantly higher risk of facture when compared to matched controls (17.6% versus 11.7%, respectively pbipolar disorder and a prior history of psychiatric hospitalization were had higher risk for bone fracture than those without prior history of psychiatric hospitalization when compared to match controls. Higher cumulative dose of antipsychotics or mood stabilizers did not increase the risk of fracture. The diagnoses of bipolar disorder were not confirmed with structured clinical interview. Drug adherence, exact exposure dosage, smoking, lifestyle, nutrition and exercise habits were unable to be assessed in our dataset. Bipolar disorder is associated with increased risk of fracture, and higher cumulative dose of mood stabilizers and antipsychotics did not further increase the risk of fracture. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Pituitary gland volumes in bipolar disorder.

    Science.gov (United States)

    Clark, Ian A; Mackay, Clare E; Goodwin, Guy M

    2014-12-01

    Bipolar disorder has been associated with increased Hypothalamic-Pituitary-Adrenal axis function. The mechanism is not well understood, but there may be associated increases in pituitary gland volume (PGV) and these small increases may be functionally significant. However, research investigating PGV in bipolar disorder reports mixed results. The aim of the current study was twofold. First, to assess PGV in two novel samples of patients with bipolar disorder and matched healthy controls. Second, to perform a meta-analysis comparing PGV across a larger sample of patients and matched controls. Sample 1 consisted of 23 established patients and 32 matched controls. Sample 2 consisted of 39 medication-naïve patients and 42 matched controls. PGV was measured on structural MRI scans. Seven further studies were identified comparing PGV between patients and matched controls (total n; 244 patients, 308 controls). Both novel samples showed a small (approximately 20mm(3) or 4%), but non-significant, increase in PGV in patients. Combining the two novel samples showed a significant association of age and PGV. Meta-analysis showed a trend towards a larger pituitary gland in patients (effect size: .23, CI: -.14, .59). While results suggest a possible small difference in pituitary gland volume between patients and matched controls, larger mega-analyses with sample sizes greater even than those used in the current meta-analysis are still required. There is a small but potentially functionally significant increase in PGV in patients with bipolar disorder compared to controls. Results demonstrate the difficulty of finding potentially important but small effects in functional brain disorders. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Interfacial patterns in magnetorheological fluids: Azimuthal field-induced structures.

    Science.gov (United States)

    Dias, Eduardo O; Lira, Sérgio A; Miranda, José A

    2015-08-01

    Despite their practical and academic relevance, studies of interfacial pattern formation in confined magnetorheological (MR) fluids have been largely overlooked in the literature. In this work, we present a contribution to this soft matter research topic and investigate the emergence of interfacial instabilities when an inviscid, initially circular bubble of a Newtonian fluid is surrounded by a MR fluid in a Hele-Shaw cell apparatus. An externally applied, in-plane azimuthal magnetic field produced by a current-carrying wire induces interfacial disturbances at the two-fluid interface, and pattern-forming structures arise. Linear stability analysis, weakly nonlinear theory, and a vortex sheet approach are used to access early linear and intermediate nonlinear time regimes, as well as to determine stationary interfacial shapes at fully nonlinear stages.

  17. Asenapine for bipolar disorder

    Directory of Open Access Journals (Sweden)

    Scheidemantel T

    2015-12-01

    Full Text Available Thomas Scheidemantel,1 Irina Korobkova,2 Soham Rej,3,4 Martha Sajatovic1,2 1University Hospitals Case Medical Center, 2Case Western Reserve University School of Medicine, Cleveland, OH, USA; 3Department of Psychiatry, University of Toronto, Toronto, ON, 4Geri PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada Abstract: Asenapine (Saphris® is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of administration. In this review, we examine and summarize the available literature on the safety, efficacy, and tolerability of asenapine in the treatment of bipolar disorder (BD. Data from randomized, double-blind trials comparing asenapine to placebo or olanzapine in the treatment of acute manic or mixed episodes showed asenapine to be an effective monotherapy treatment in clinical settings; asenapine outperformed placebo and showed noninferior performance to olanzapine based on improvement in the Young Mania Rating Scale scores. There are limited data available on the use of asenapine in the treatment of depressive symptoms of BD, or in the maintenance phase of BD. The available data are inconclusive, suggesting the need for more robust data from prospective trials in these clinical domains. The most commonly reported adverse effect associated with use of asenapine is somnolence. However, the somnolence associated with asenapine use did not cause significant rates of discontinuation. While asenapine was associated with weight gain when compared to placebo, it appeared to be modest when compared to other atypical antipsychotics, and its propensity to cause increases in hemoglobin A1c or serum lipid levels appeared to be

  18. The effective field theory of cosmological large scale structures

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco, John Joseph M. [Stanford Univ., Stanford, CA (United States); Hertzberg, Mark P. [Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States); Senatore, Leonardo [Stanford Univ., Stanford, CA (United States); SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2012-09-20

    Large scale structure surveys will likely become the next leading cosmological probe. In our universe, matter perturbations are large on short distances and small at long scales, i.e. strongly coupled in the UV and weakly coupled in the IR. To make precise analytical predictions on large scales, we develop an effective field theory formulated in terms of an IR effective fluid characterized by several parameters, such as speed of sound and viscosity. These parameters, determined by the UV physics described by the Boltzmann equation, are measured from N-body simulations. We find that the speed of sound of the effective fluid is c2s ≈ 10–6c2 and that the viscosity contributions are of the same order. The fluid describes all the relevant physics at long scales k and permits a manifestly convergent perturbative expansion in the size of the matter perturbations δ(k) for all the observables. As an example, we calculate the correction to the power spectrum at order δ(k)4. As a result, the predictions of the effective field theory are found to be in much better agreement with observation than standard cosmological perturbation theory, already reaching percent precision at this order up to a relatively short scale k ≃ 0.24h Mpc–1.

  19. Review on structured optical field generated from array beams

    Science.gov (United States)

    Hou, Tianyue; Zhou, Pu; Ma, Yanxing; Zhi, Dong

    2018-03-01

    Structured optical field (SOF), which includes vortex beams, non-diffraction beams, cylindrical vector beams and so on, has been under intensive investigation theoretically and experimentally in recent years. Generally, current research focus on the extraordinary properties (non-diffraction propagation, helical wavefront, rotation of electrical field, et al), which can be widely applied in micro-particle manipulation, super-resolution imaging, free-space communication and so on. There are mainly two technical routes, that is, inner-cavity and outer-cavity (spatial light modulators, diffractive phase holograms, q-plates). To date, most of the SOFs generated from both technical routes involves with single monolithic beam. As a novel technical route, SOF based on array beams has the advantage in more flexible freedom degree and power scaling potential. In this paper, research achievements in SOF generation based on array beams are arranged and discussed in detail. Moreover, experiment of generating exotic beam by array beams is introduced, which illustrates that SOF generated from array beams is theoretically valid and experimentally feasible. SOF generated from array beams is also beneficial for capacity increasing and data receiving for free-space optical communication systems at long distance.

  20. Stacks with TiN/titanium as the bipolar plate for PEMFCs

    International Nuclear Information System (INIS)

    Ren, Zhijun; Zhang, Dongming; Wang, Zaiyi

    2012-01-01

    Proton exchange membrane fuel cell (PEMFC) is a potential alternative for the internal combustion engine. But many problems, such as metallic bipolar plate instead of graphite bipolar plate to decrease the cost, should be solved before its application. Based on the previous results that single cell with TiN/Ti as bipolar plates shows high performance and enough long-time durability, the progress on the stacks with TiN/Ti as bipolar plates is reported in this manuscript. Till now seldom report is focused on stacks because of the complicated processing technique, especially for that with TiN/Ti as bipolar plate. The flow field in the plate is punched from titanium deformation, and two plates are welded by laser welding to form one piece of bipolar plate. The adopted processing techniques for stacks with TiN/Ti as bipolar plate exhibit advantage and feasibility in industry. The power density by weight for the stack is as high as 1353 W kg −1 , although it still has space to be improved. Next work should be focused on the design of flow channel parameters and flow field type based on plastic deformation of metal materials. -- Highlights: ► The progress on the stacks with TiN/Ti as bipolar plates is reported. ► The adopted processing techniques exhibit feasibility in industry. ► The power density by weight for the stack is as high as 1353 W kg −1 .

  1. Protein 8-class secondary structure prediction using conditional neural fields.

    Science.gov (United States)

    Wang, Zhiyong; Zhao, Feng; Peng, Jian; Xu, Jinbo

    2011-10-01

    Compared with the protein 3-class secondary structure (SS) prediction, the 8-class prediction gains less attention and is also much more challenging, especially for proteins with few sequence homologs. This paper presents a new probabilistic method for 8-class SS prediction using conditional neural fields (CNFs), a recently invented probabilistic graphical model. This CNF method not only models the complex relationship between sequence features and SS, but also exploits the interdependency among SS types of adjacent residues. In addition to sequence profiles, our method also makes use of non-evolutionary information for SS prediction. Tested on the CB513 and RS126 data sets, our method achieves Q8 accuracy of 64.9 and 64.7%, respectively, which are much better than the SSpro8 web server (51.0 and 48.0%, respectively). Our method can also be used to predict other structure properties (e.g. solvent accessibility) of a protein or the SS of RNA. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Reframing measurement for structural health monitoring: a full-field strategy for structural identification

    Science.gov (United States)

    Dizaji, Mehrdad S.; Harris, Devin K.; Alipour, Mohamad; Ozbulut, Osman E.

    2018-03-01

    Structural health monitoring (SHM) describes a decision-making framework that is fundamentally guided by state change detection of structural systems. This framework typically relies on the use of continuous or semi-continuous monitoring of measured response to quantify this state change in structural system behavior, which is often related to the initiation of some form of damage. Measurement approaches used for traditional SHM are numerous, but most are limited to either describing localized or global phenomena, making it challenging to characterize operational structural systems which exhibit both. In addition to these limitations in sensing, SHM has also suffered from the inherent robustness inherent to most full-scale structural systems, making it challenging to identify local damage. These challenges highlight the opportunity for alternative strategies for SHM, strategies that are able to provide data suitable to translate into rich information. This paper describes preliminary results from a refined structural identification (St-ID) approach using fullfield measurements derived from high-speed 3D Digital Image Correlation (HSDIC) to characterize uncertain parameters (i.e. boundary and constitutive properties) of a laboratory scale structural component. The St-ID approach builds from prior work by supplementing full-field deflection and strain response with vibration response derived from HSDIC. Inclusion of the modal characteristics within a hybrid-genetic algorithm optimization scheme allowed for simultaneous integration of mechanical and modal response, thus enabling a more robust St-ID strategy than could be achieved with traditional sensing techniques. The use of full-field data is shown to provide a more comprehensive representation of the global and local behavior, which in turn increases the robustness of the St-Id framework. This work serves as the foundation for a new paradigm in SHM that emphasizes characterizing structural performance using a

  3. Conductivity-limiting bipolar thermal conductivity in semiconductors

    Science.gov (United States)

    Wang, Shanyu; Yang, Jiong; Toll, Trevor; Yang, Jihui; Zhang, Wenqing; Tang, Xinfeng

    2015-01-01

    Intriguing experimental results raised the question about the fundamental mechanisms governing the electron-hole coupling induced bipolar thermal conduction in semiconductors. Our combined theoretical analysis and experimental measurements show that in semiconductors bipolar thermal transport is in general a “conductivity-limiting” phenomenon, and it is thus controlled by the carrier mobility ratio and by the minority carrier partial electrical conductivity for the intrinsic and extrinsic cases, respectively. Our numerical method quantifies the role of electronic band structure and carrier scattering mechanisms. We have successfully demonstrated bipolar thermal conductivity reduction in doped semiconductors via electronic band structure modulation and/or preferential minority carrier scatterings. We expect this study to be beneficial to the current interests in optimizing thermoelectric properties of narrow gap semiconductors. PMID:25970560

  4. Cortical complexity in bipolar disorder applying a spherical harmonics approach.

    Science.gov (United States)

    Nenadic, Igor; Yotter, Rachel A; Dietzek, Maren; Langbein, Kerstin; Sauer, Heinrich; Gaser, Christian

    2017-05-30

    Recent studies using surface-based morphometry of structural magnetic resonance imaging data have suggested that some changes in bipolar disorder (BP) might be neurodevelopmental in origin. We applied a novel analysis of cortical complexity based on fractal dimensions in high-resolution structural MRI scans of 18 bipolar disorder patients and 26 healthy controls. Our region-of-interest based analysis revealed increases in fractal dimensions (in patients relative to controls) in left lateral orbitofrontal cortex and right precuneus, and decreases in right caudal middle frontal, entorhinal cortex, and right pars orbitalis, and left fusiform and posterior cingulate cortices. While our analysis is preliminary, it suggests that early neurodevelopmental pathologies might contribute to bipolar disorder, possibly through genetic mechanisms. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  5. Modeling suicide in bipolar disorders.

    Science.gov (United States)

    Malhi, Gin S; Outhred, Tim; Das, Pritha; Morris, Grace; Hamilton, Amber; Mannie, Zola

    2018-02-19

    Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative that our current understanding be improved to facilitate prediction of suicide and its prevention. In this review, we provide a new perspective on the process of suicide in bipolar disorder, in the form of a novel integrated model that is derived from extant knowledge and recent evidence. A literature search of articles on suicide in bipolar disorder was conducted in recognized databases such as Scopus, PubMed, and PsycINFO using the keywords "suicide", "suicide in bipolar disorders", "suicide process", "suicide risk", "neurobiology of suicide" and "suicide models". Bibliographies of identified articles were further scrutinized for papers and book chapters of relevance. Risk factors for suicide in bipolar disorders are well described, and provide a basis for a framework of epigenetic mechanisms, moderated by neurobiological substrates, neurocognitive functioning, and social inferences within the environment. Relevant models and theories include the diathesis-stress model, the bipolar model of suicide and the ideation-to-action models, the interpersonal theory of suicide, the integrated motivational-volitional model, and the three-step theory. Together, these models provide a basis for the generation of an integrated model that illuminates the suicidal process, from ideation to action. Suicide is complex, and it is evident that a multidimensional and integrated approach is required to reduce its prevalence. The proposed model exposes and provides access to components of the suicide process that are potentially measurable and may serve as novel and specific therapeutic targets for interventions in the context of bipolar disorder. Thus, this model is useful not only

  6. Bipolar explosion models for hypernovae

    International Nuclear Information System (INIS)

    Maeda, Keiichi; Nomoto, Ken'ichi

    2003-01-01

    Bipolar explosion models for hypernovae (very energetic supernovae) are presented. These models provide a favorable situation to explain some unexpected features in observations of hypernovae, e.g., high velocity matter dominated by Fe and low velocity matter dominated by O. The overall abundance of these models gives a good fit, at least qualitatively, to abundances in extremely metal-poor stars. We suggest hypernovae be driven by bipolar jets and contribute significantly to the early Galactic chemical evolution

  7. Functional remediation for bipolar disorder

    OpenAIRE

    Martínez-Arán, Anabel, 1971-; Torrent, C.; Solé, B.; Bonnín, C.M.; Rosa, A.R.; Sánchez-Moreno, J.; Vieta i Pascual, Eduard, 1963-

    2014-01-01

    Neurocognitive impairment constitutes a core feature of bipolar illness. The main domains affected are verbal memory, attention, and executive functions. Deficits in these areas as well as difficulties to get functional remission seem to be increased associated with illness progression. Several studies have found a strong relationship between neurocognitive impairment and low functioning in bipolar disorder, as previously reported in other illnesses such as schizophrenia. Cognitive remediatio...

  8. A Hamiltonian structure for the linearized Einstein vacuum field equations

    International Nuclear Information System (INIS)

    Torres del Castillo, G.F.

    1991-01-01

    By considering the Einstein vacuum field equations linearized about the Minkowski metric, the evolution equations for the gauge-invariant quantities characterizing the gravitational field are written in a Hamiltonian form. A Poisson bracket between functionals of the field, compatible with the constraints satisfied by the field variables, is obtained (Author)

  9. Size distribution and structure of Barchan dune fields

    Directory of Open Access Journals (Sweden)

    O. Durán

    2011-07-01

    Full Text Available Barchans are isolated mobile dunes often organized in large dune fields. Dune fields seem to present a characteristic dune size and spacing, which suggests a cooperative behavior based on dune interaction. In Duran et al. (2009, we propose that the redistribution of sand by collisions between dunes is a key element for the stability and size selection of barchan dune fields. This approach was based on a mean-field model ignoring the spatial distribution of dune fields. Here, we present a simplified dune field model that includes the spatial evolution of individual dunes as well as their interaction through sand exchange and binary collisions. As a result, the dune field evolves towards a steady state that depends on the boundary conditions. Comparing our results with measurements of Moroccan dune fields, we find that the simulated fields have the same dune size distribution as in real fields but fail to reproduce their homogeneity along the wind direction.

  10. A quantum group structure in integrable conformal field theories

    International Nuclear Information System (INIS)

    Smit, D.J.

    1990-01-01

    We discuss a quantization prescription of the conformal algebras of a class of d=2 conformal field theories which are integrable. We first give a geometrical construction of certain extensions of the classical Virasoro algebra, known as classical W algebras, in which these algebras arise as the Lie algebra of the second Hamiltonian structure of a generalized Korteweg-de Vries hierarchy. This fact implies that the W algebras, obtained as a reduction with respect to the nilpotent subalgebras of the Kac-Moody algebra, describe the intergrability of a Toda field theory. Subsequently we determine the coadjoint operators of the W algebras, and relate these to classical Yang-Baxter matrices. The quantization of these algebras can be carried out using the concept of a so-called quantum group. We derive the condition under which the representations of these quantum groups admit a Hilbert space completion by exploring the relation with the braid group. Then we consider a modification of the Miura transformation which we use to define a quantum W algebra. This leads to an alternative interpretation of the coset construction for Kac-Moody algebras in terms of nonlinear integrable hierarchies. Subsequently we use the connection between the induced braid group representations and the representations of the mapping class group of Riemann surfaces to identify an action of the W algebras on the moduli space of stable curves, and we give the invariants of this action. This provides a generalization of the situation for the Virasoro algebra, where such an invariant is given by the so-called Mumford form which describes the partition function of the bosonic string. (orig.)

  11. Vibrational Properties of High- Superconductors Levitated Above a Bipolar Permanent Magnetic Guideway

    Science.gov (United States)

    Liu, Lu; Wang, Jiasu

    2014-05-01

    A bipolar permanent magnetic guideway (PMG) has a unique magnetic field distribution profile which may introduce a better levitation performance and stability to the high- superconducting (HTS) maglev system. The dynamic vibration properties of multiple YBCO bulks arranged into different arrays positioned above a bipolar PMG and free to levitate were investigated. The acceleration and resonance frequencies were experimentally measured, and the stiffness and damping coefficients were evaluated for dynamic stability. Results indicate that the levitation stiffness is closely related to the field-cooling-height and sample positioning. The damping ratio was found to be low and nonlinear for the Halbach bipolar HTS-PMG system.

  12. Field emission from optimized structure of carbon nanotube field emitter array

    International Nuclear Information System (INIS)

    Chouhan, V.; Noguchi, T.; Kato, S.

    2016-01-01

    The authors report a detail study on the emission properties of field emitter array (FEA) of micro-circular emitters of multiwall carbon nanotubes (CNTs). The FEAs were fabricated on patterned substrates prepared with an array of circular titanium (Ti) islands on titanium nitride coated tantalum substrates. CNTs were rooted into these Ti islands to prepare an array of circular emitters. The circular emitters were prepared in different diameters and pitches in order to optimize their structure for acquiring a high emission current. The pitch was varied from 0 to 600 μm, while a diameter of circular emitters was kept constant to be 50 μm in order to optimize a pitch. For diameter optimization, a diameter was changed from 50 to 200 μm while keeping a constant edge-to-edge distance of 150 μm between the circular emitters. The FEA with a diameter of 50 μm and a pitch of 120 μm was found to be the best to achieve an emission current of 47 mA corresponding to an effective current density of 30.5 A/cm"2 at 7 V/μm. The excellent emission current was attributed to good quality of CNT rooting into the substrate and optimized FEA structure, which provided a high electric field on a whole circular emitter of 50 μm and the best combination of the strong edge effect and CNT coverage. The experimental results were confirmed with computer simulation.

  13. Field emission from optimized structure of carbon nanotube field emitter array

    Energy Technology Data Exchange (ETDEWEB)

    Chouhan, V., E-mail: vchouhan@post.kek.jp, E-mail: vijaychouhan84@gmail.com [School of High Energy Accelerator, The Graduate University for Advanced Studies, Tsukuba 305-0801 (Japan); Noguchi, T. [High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801 (Japan); Kato, S. [School of High Energy Accelerator, The Graduate University for Advanced Studies, Tsukuba 305-0801 (Japan); High Energy Accelerator Research Organization (KEK), Tsukuba 305-0801 (Japan)

    2016-04-07

    The authors report a detail study on the emission properties of field emitter array (FEA) of micro-circular emitters of multiwall carbon nanotubes (CNTs). The FEAs were fabricated on patterned substrates prepared with an array of circular titanium (Ti) islands on titanium nitride coated tantalum substrates. CNTs were rooted into these Ti islands to prepare an array of circular emitters. The circular emitters were prepared in different diameters and pitches in order to optimize their structure for acquiring a high emission current. The pitch was varied from 0 to 600 μm, while a diameter of circular emitters was kept constant to be 50 μm in order to optimize a pitch. For diameter optimization, a diameter was changed from 50 to 200 μm while keeping a constant edge-to-edge distance of 150 μm between the circular emitters. The FEA with a diameter of 50 μm and a pitch of 120 μm was found to be the best to achieve an emission current of 47 mA corresponding to an effective current density of 30.5 A/cm{sup 2} at 7 V/μm. The excellent emission current was attributed to good quality of CNT rooting into the substrate and optimized FEA structure, which provided a high electric field on a whole circular emitter of 50 μm and the best combination of the strong edge effect and CNT coverage. The experimental results were confirmed with computer simulation.

  14. Quetiapine monotherapy for bipolar depression

    Directory of Open Access Journals (Sweden)

    Michael E Thase

    2008-03-01

    Full Text Available Michael E ThaseDepartments of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; and the University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: Bipolar depression is more common, disabling, and difficult-to-treat than the manic and hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” depressions, antidepressants generally are not indicated as monotherapies for bipolar depressions and recent studies suggest that - even when used in combination with traditional mood stabilizers – antidepressants may have questionable value for bipolar depression. The current practice is that mood stabilizers are initiated first as monotherapies; however, the antidepressant efficacy of lithium and valproate is modest at best. Within this context the role of atypical antipsychotics is being evaluated. The combination of olanzapine and the antidepressant fluoxetine was the first treatment to receive regulatory approval in the US specifically for bipolar I depression. Quetiapine was the second medication to be approved for this indication, largely as the result of two pivotal trials known by the acronyms of BOLDER (BipOLar DEpRession I and II. Both studies demonstrated that two doses of quetiapine (300 mg and 600 mg given once daily at bedtime were significantly more effective than placebo, with no increased risk of patients switching into mania. Pooling the two studies, quetiapine was effective for both bipolar I and bipolar II depressions and for patients with (and without a history of rapid cycling. The two doses were comparably effective in both studies. Although the efficacy of quetiapine monotherapy has been established, much additional research is necessary. Further studies are needed to more fully investigate dose-response relationships and comparing quetiapine monotherapy to other mood stabilizers

  15. Evaluation of the impact of two flow field designs with bipolar plate flow on the performance of a PEM fuel cell; Evaluacion del impacto de dos disenos de campo de flujo de placa bipolar en el desempeno de una celda de combustible tipo PEM

    Energy Technology Data Exchange (ETDEWEB)

    Loyola-Morales, F.; Cano-Castillo, U. [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)]. E-mail: feloyola@yahoo.com.mx

    2009-09-15

    The flow field (FF) designs of bipolar plates play a fundamental role in the performance of a set of PEM fuel cells. The FF is directly related with diverse processes that occur inside the cells, such as: feeding and uniform distribution of reactant gases and the handling of water produced by the overall electrochemical reaction. Therefore, a FF design that promotes each one of those processes in an optimal manner is of utmost importance to attain the best performance of a set of fuel cells. The present work evaluated the impact of two different FF on the performance of a fuel cell. The FF designs evaluated were 4 serpentine and parallels (4SP) and 2 serpentine counter flow (SC). The stability tests for the operation of the cell applied to each of the flow fields were: flood tolerance, dehydration tolerance conditions and stoichiometry performance of 1.1, 1.3, 1.5 and 2.5. The 4SP design showed high performance stability during operation with a gradual process of flooding the system and operating at different stoichiometries. Only for the test with dehydration conditions was there a gradual decrease in its performance, of up to 27%. Compared to these results, the SC design showed a rapid fall of 45% in its performance when operating under gradual flooding of the system, a constant fall in its performance (also around 45%) with stoichiometries of 1.1, 1.3 and 1.5 due to accumulation of water, and only with a stoichiometry of 2.5 did it have highly stable performance as a result of good water handling. In the test of operations under dehydration conditions, the performance of the SC design dropped to 40% and remained at this value during the rest of the test. According to these results, the performance of the 4SP design was more stable than the SC design for all of the tests implemented. [Spanish] Los disenos de campo de flujo (CF) de las placas bipolares tienen un papel fundamental en el desempeno de un conjunto de celdas de combustible tipo PEM. Los CF tienen una

  16. Structural aspects of Lorentz-violating quantum field theory

    Science.gov (United States)

    Cambiaso, M.; Lehnert, R.; Potting, R.

    2018-01-01

    In the last couple of decades the Standard Model Extension has emerged as a fruitful framework to analyze the empirical and theoretical extent of the validity of cornerstones of modern particle physics, namely, of Special Relativity and of the discrete symmetries C, P and T (or some combinations of these). The Standard Model Extension allows to contrast high-precision experimental tests with posited alterations representing minute Lorentz and/or CPT violations. To date no violation of these symmetry principles has been observed in experiments, mostly prompted by the Standard-Model Extension. From the latter, bounds on the extent of departures from Lorentz and CPT symmetries can be obtained with ever increasing accuracy. These analyses have been mostly focused on tree-level processes. In this presentation I would like to comment on structural aspects of perturbative Lorentz violating quantum field theory. I will show that some insight coming from radiative corrections demands a careful reassessment of perturbation theory. Specifically I will argue that both the standard renormalization procedure as well as the Lehmann-Symanzik-Zimmermann reduction formalism need to be adapted given that the asymptotic single-particle states can receive quantum corrections from Lorentz-violating operators that are not present in the original Lagrangian.

  17. Coherent drift wave structures in sheared magnetic fields

    International Nuclear Information System (INIS)

    Morrison, P.J.; Horton, W.

    1993-01-01

    For the problem of calculating the coherent drift wave structures in sheared magnetic fields, the authors have found it useful to derive the governing nonlinear pde from a variational principle. The variational principle is based on the free energy functional F[var-phi] = ∫ V F(var-phi, ∇ var-phi, x)dx dy. The method is applied to the vortex with speed u derived in Su et al., given by ∇ 2 var-phi = (1 - v d /u) var-phi - S m 2 /u 2 (x - var-phi/u) (x - var-phi/2u) var-phi where space is measured in units of ρ s , var-phi = (eΦ/T e )(L n /ρ s ) and the magnetic shear parameter is S m . While the linearized problem (var-phi much-lt ux) describes the usual shear induced damping, nonlinear solutions with trapped flow (var-phi > ur 0 ) form nonlinear self-bound states, which are maxima of the free energy F. The authors discuss the analytic properties and the numerical procedures for solving these types of nonlinear pde's

  18. ON Cone Bipolar Cell Axonal Synapses in the OFF Inner Plexiform Layer of the Rabbit Retina

    Science.gov (United States)

    Lauritzen, J. Scott; Anderson, James R.; Jones, Bryan W.; Watt, Carl B.; Mohammed, Shoeb; Hoang, John V.; Marc, Robert E.

    2012-01-01

    Analysis of the rabbit retinal connectome RC1 reveals that the division between the ON and OFF inner plexiform layer (IPL) is not structurally absolute. ON cone bipolar cells make non-canonical axonal synapses onto specific targets and receive amacrine cell synapses in the nominal OFF layer, creating novel motifs, including inhibitory crossover networks. Automated transmission electron microscope (ATEM) imaging, molecular tagging, tracing, and rendering of ≈ 400 bipolar cells reveals axonal ribbons in 36% of ON cone bipolar cells, throughout the OFF IPL. The targets include GABA-positive amacrine cells (γACs), glycine-positive amacrine cells (GACs) and ganglion cells. Most ON cone bipolar cell axonal contacts target GACs driven by OFF cone bipolar cells, forming new architectures for generating ON-OFF amacrine cells. Many of these ON-OFF GACs target ON cone bipolar cell axons, ON γACs and/or ON-OFF ganglion cells, representing widespread mechanisms for OFF to ON crossover inhibition. Other targets include OFF γACs presynaptic to OFF bipolar cells, forming γAC-mediated crossover motifs. ON cone bipolar cell axonal ribbons drive bistratified ON-OFF ganglion cells in the OFF layer and provide ON drive to polarity-appropriate targets such as bistratified diving ganglion cells (bsdGCs). The targeting precision of ON cone bipolar cell axonal synapses shows that this drive incidence is necessarily a joint distribution of cone bipolar cell axonal frequency and target cell trajectories through a given volume of the OFF layer. Such joint distribution sampling is likely common when targets are sparser than sources and when sources are coupled, as are ON cone bipolar cells. PMID:23042441

  19. Mechanisms underlying the benefits of anticonvulsants over lithium in the treatment of bipolar disorder.

    Science.gov (United States)

    Corrado, Alisa C; Walsh, John P

    2016-02-10

    Close to 3% of the world's population suffers from bipolar disease (I and II). Of this 3%, bipolar disease affects largely women (∼ 3 : 2 compared with men). The median age of diagnosis is 25 in women and even lower in men. A diagnosis of bipolar disease is an expensive psychiatric diagnosis, costing patients more than twice as much money as a diagnosis of unipolar depression. Bipolar I is characterized by one or more manic or mixed episodes, with both mania and depression occurring each day for at least 1 week, whereas bipolar II is characterized by one or more major depressive episode and at least one episode of hypomania. Bipolar I is the more severe diagnosis. A wide range of medications are available to help patients maintain a healthy lifestyle, including lithium, antidepressants, and anticonvulsants. Improved methods for identifying bipolar disease, including a more structured approach and a more complete use of medical records, have increased the rate of diagnosis, especially in children, which underscores the need for innovation in development and in practice of new treatment options for treating bipolar disease. Although lithium has been the 'gold standard' for treating bipolar disorder for decades, new research into other forms of treatment has shown anticonvulsants to be a particularly useful therapy for treating bipolar disease. Anticonvulsants have remarkable mood-stabilization abilities and they do not lead to serious side effects, which increases the tolerability, and consequently, patient adherence to this form of treatment. Recent studies have shown that anticonvulsants improve behavior in bipolar disease by modulating the balance of excitatory and inhibitory synapses through a number of complementary molecular cascades that affect gene expression and cell survival.

  20. Perisylvian GABA levels in schizophrenia and bipolar disorder.

    Science.gov (United States)

    Atagün, Murat İlhan; Şıkoğlu, Elif Muazzez; Soykan, Çağlar; Serdar Süleyman, Can; Ulusoy-Kaymak, Semra; Çayköylü, Ali; Algın, Oktay; Phillips, Mary Louise; Öngür, Dost; Moore, Constance Mary

    2017-01-10

    The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy ( 1 H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1 H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [χ 2 =9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r 2 =0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. On the stochastic structure of globally supersymmetric field theories

    International Nuclear Information System (INIS)

    Flume, R.; Lechtenfeld, O.

    1983-09-01

    We reformulate the bosonic sector of globally supersymmetric field theories through a ''fermionisation'' of bosonic Feynman graphs. The recipe for the fermionisation gives an explicit realisation of the Nicolai map. The graphical rules for supersymmetric Yang-Mills fields in the reformulated version turn out to be simpler than those of ordinary Yang-Mills fields. (orig.)

  2. Morphology of bipolar planetary nebulae. I. Two-dimensional spectrophotometry

    International Nuclear Information System (INIS)

    Pascoli, G.

    1990-01-01

    Two-dimensional spectrophotometric observations of bipolar planetary nebulae were performed by using a CCD detector mounted at the Cassegrain focus of either 1.54 m Danish Telescope or 2.2 m German Telescope at La Silla (ESO) in Chile. Emission lines have been selected with the help of narrow band-pass interference filters (Δλ∼ 10 - 20 A). Isophotal maps in various lines Hα, [NII] λ 6584, [OIII] λ 5007 and [SII] λλ 6717-6731 are presented. Particular attention has been given to scrutinize the symmetries inside a few bipolar planetary nebulae, in order to subsequently investigate their space structure

  3. Bipolar Disorder and Alcoholism: Are They Related?

    Science.gov (United States)

    ... Are they related? Is there a connection between bipolar disorder and alcoholism? Answers from Daniel K. Hall-Flavin, M.D. Bipolar disorder and alcoholism often occur together. Although the association ...

  4. Impulse control disorder comorbidity among patients with bipolar I disorder.

    Science.gov (United States)

    Karakus, Gonca; Tamam, Lut

    2011-01-01

    Impulsivity is associated with mood instability, behavioral problems, and action without planning in patients with bipolar disorder. Increased impulsivity levels are reported at all types of mood episodes. This association suggests a high comorbidity between impulse control disorders (ICDs) and bipolar disorder. The aim of this study is to compare the prevalence of ICDs and associated clinical and sociodemographic variables in euthymic bipolar I patients. A total of 124 consecutive bipolar I patients who were recruited from regular attendees from the outpatient clinic of our Bipolar Disorder Unit were included in the study. All patients were symptomatically in remission. Diagnosis of bipolar disorder was confirmed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Impulse control disorders were investigated using the modified version of the Minnesota Impulsive Disorders Interview. Impulsivity was measured with the Barratt Impulsiveness Scale Version 11. Furthermore, all patients completed the Zuckerman Sensation-Seeking Scale Form V. The prevalence rate of all comorbid ICDs in our sample was 27.4% (n = 34). The most common ICD subtype was pathologic skin picking, followed by compulsive buying, intermittent explosive disorder, and trichotillomania. There were no instances of pyromania or compulsive sexual behavior. There was no statistically significant difference between the sociodemographic characteristics of bipolar patients with and without ICDs with regard to age, sex, education level, or marital status. Comorbidity of alcohol/substance abuse and number of suicide attempts were higher in the ICD(+) group than the ICD(-) group. Length of time between mood episodes was higher in the ICD(-) group than the ICD(+) group. There was a statistically significant difference between the total number of mood episodes between the 2 groups, but the number of depressive episodes was higher in the ICD(+) patients

  5. The burden on informal caregivers of people with bipolar disorder.

    Science.gov (United States)

    Ogilvie, Alan D; Morant, Nicola; Goodwin, Guy M

    2005-01-01

    Caregivers of people with bipolar disorder may experience a different quality of burden than is seen with other illnesses. A better understanding of their concerns is necessary to improve the training of professionals working with this population. Conceptualizing caregiver burden in a conventional medical framework may not focus enough on issues important to caregivers, or on cultural and social issues. Perceptions of caregivers about bipolar disorder have important effects on levels of burden experienced. It is important to distinguish between caregivers' experience of this subjective burden and objective burden as externally appraised. Caregivers' previous experiences of health services may influence their beliefs about the illness. Caregiver burden is associated with depression, which affects patient recovery by adding stress to the living environment. The objective burden on caregivers of patients with bipolar disorder is significantly higher than for those with unipolar depression. Caregivers of bipolar patients have high levels of expressed emotion, including critical, hostile, or over-involved attitudes. Several measures have been developed to assess the care burden of patients with depressive disorders, but may be inappropriate for patients with bipolar disorder because of its cyclical nature and the stresses arising from manic and hypomanic episodes. Inter-episode symptoms pose another potential of burden in patients with bipolar disorder. Subsyndromal depressive symptoms are common in this phase of the illness, resulting in severe and widespread impairment of function. Despite the importance of assessing caregiver burden in bipolar disorder, relevant literature is scarce. The specific effects of mania and inter-episode symptoms have not been adequately addressed, and there is a lack of existing measures to assess burden adequately, causing uncertainty regarding how best to structure family interventions to optimally alleviate burden. The relatively few

  6. Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness.

    Science.gov (United States)

    Swann, A C; Lijffijt, M; Lane, S D; Steinberg, J L; Moeller, F G

    2010-06-01

    We investigated trait impulsivity in bipolar disorder and antisocial personality disorder (ASPD) with respect to severity and course of illness. Subjects included 78 controls, 34 ASPD, 61 bipolar disorder without Axis II disorder, and 24 bipolar disorder with ASPD, by Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-I and -II). Data were analyzed using general linear model and probit analysis. Barratt Impulsiveness Scale (BIS-11) scores were higher in ASPD (effect sizes 0.5-0.8) or bipolar disorder (effect size 1.45) than in controls. Subjects with both had more suicide attempts and previous episodes than bipolar disorder alone, and more substance-use disorders and suicide attempts than ASPD alone. BIS-11 scores were not related to severity of crimes. Impulsivity was higher in bipolar disorder with or without ASPD than in ASPD alone, and higher in ASPD than in controls. Adverse effects of bipolar disorder in ASPD, but not of ASPD in bipolar disorder, were accounted for by increased impulsivity.

  7. CarbonNanoTubes (CNT) in bipolar plates for PEM fuel cell applications

    Energy Technology Data Exchange (ETDEWEB)

    Grundler, M.; Derieth, T.; Beckhaus, P.; Heinzel, A. [centre for fuel cell technology ZBT GmbH (Germany)

    2010-07-01

    Using standard mass production techniques for the fabrication of fuel cell components, such as bipolar plates, is a main issue for the commercialisation of PEM fuel cell systems. Bipolar plates contribute significantly to the cost structure of PEM stacks. In an upcoming fuel cell market a large number of bipolar plates with specific high-quality standards will be needed. At the Centre for Fuel Cell Technology (ZBT) together with the University of Duisburg-Essen fuel cell stacks based on injection moulded bipolar plates have been developed and demonstrated successfully [1]. This paper focuses on the interactions between carbon filling materials (graphite, carbon black and carbon nanotubes (CNT)) in compound based bipolar plates and especially the potential of CNTs, which were used in bipolar plates for the first time. The entire value added chain based on the feedstock, the compounding and injection moulding process, the component bipolar plate, up to the operation of a PEM single fuel cell stack with CNT-based bipolar plates is disclosed. (orig.)

  8. Bipolar outflow in B335

    International Nuclear Information System (INIS)

    Hirano, N.; Kameya, O.; Nakayama, M.; Takakubo, K.

    1988-01-01

    The high-velocity (C-12)O (J = 1-0) emission in B335 with a high angular resolution of 16 arcsec has been mapped. The high-velocity emission shows distinct bipolar pattern centered at IRAS 19345+0727, toward which a strong high-velocity (C-12)O emission has been detected. The bipolar lobes delineate remarkable collimation toward the IRAS source, indicating that the flow is focused within 0.02 pc of the driving source. Each lobe is accompanied by significant wing emission with the opposite velocity shift, which clearly shows the association with IRAS 19345+0727. This feature is well explained as a bipolar flow the axis of which is nearly perpendicular to the line of sight. There is no evidence of another evolved bipolar flow which does not associate with any dense core as previously suggested. This suggests that B335 is a site of very recent star formation, containing a single bipolar flow with an age of about 30,000 yr. 15 references

  9. Exercising control over bipolar disorder.

    Science.gov (United States)

    Malhi, Gin S; Byrow, Yulisha

    2016-11-01

    Following extensive research exercise has emerged as an effective treatment for major depressive disorder, and it is now a recognised therapy alongside other interventions. In contrast, there is a paucity of research examining the therapeutic effects of exercise for those with bipolar disorder. Given that dysfunctional reward processing is central to bipolar disorder, research suggests that exercise can perhaps be framed as a reward-related event that may have the potential to precipitate a manic episode. The behavioural activation system (BAS) is a neurobehavioural system that is associated with responding to reward and provides an appropriate framework to theoretically examine and better understand the effects of exercise treatment on bipolar disorder. This article discusses recent research findings and provides an overview of the extant literature related to the neurobiological underpinnings of BAS and exercise as they relate to bipolar disorder. This is important clinically because depending on mood state in bipolar disorder, we postulate that exercise could be either beneficial or deleterious with positive or negative effects on the illness. Clearly, this complicates the evaluation of exercise as a potential treatment in terms of identifying its optimal characteristics in this population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  10. Late Onset Bipolar Disorder: Case Report

    OpenAIRE

    Filipa Araújo; Adriana Horta

    2016-01-01

    Background: Bipolar disorder affects approximately 1% of the population, with diagnosis often being made during late adolescence and early adulthood, and only rarely (0.1%) in the elderly. Late onset bipolar disorder in the elderly has a impact on the nature and course of bipolar disorder. Aims: The authors report a case of bipolar disorder emerging in late life  (76years old) with no cleary identified organic cause. Conclusion: This case highlights the importance of a broad different...

  11. Differences in clinical presentation between bipolar I and II disorders in the early stages of bipolar disorder

    DEFF Research Database (Denmark)

    Vinberg, Maj; Mikkelsen, Rie Lambaek; Kirkegaard, Thomas

    2017-01-01

    Aim In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional...... level, the presence of comorbid personality disorders and coping strategies. Methods Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders. Clinical symptoms were rated with the Young Mania Rating Scale and the Hamilton Depression Rating Scale, and functional status using...... Inventory for Stressful Situations. Results In total, 344 patients were included (BD I (n=163) and BD II (n=181). Patients with BD II presented with significantly more depressive symptoms, more cognitive complaints, lower overall functioning, and a higher prevalence of comorbid personality disorders...

  12. Stochastic field line structures appearing in field line tracing calculations for a helical magnetic limiter on TORE SUPRA

    International Nuclear Information System (INIS)

    Fuchs, G.; Steffen, B.; Blenski, T.; Grosman, A.; Samain, A.

    1985-05-01

    The influence on the structure of the magnetic field of a tokamak produced by small helical currents flowing near the plasma in TORE SUPRA was investigated numerically by drawing Poincare plots. The current in the helical conductors, the pitch of the windings, the rotational transform and the plasma pressure have been varied. The topology of the magnetic field line structure is discussed in some detail and simple examples are given for illustration. (orig.)

  13. Interactions between Radial Electric Field, Transport and Structure in Helical Plasmas

    International Nuclear Information System (INIS)

    Ida, Katsumi and others

    2006-01-01

    Control of the radial electric field is considered to be important in helical plasmas, because the radial electric field and its shear are expected to reduce neoclassical and anomalous transport, respectively. Particle and heat transport, that determines the radial structure of density and electron profiles, sensitive to the structure of radial electric field. On the other hand, the radial electric field itself is determined by the plasma parameters. In general, the sign of the radial electric field is determined by the plasma collisionality, while the magnitude of the radial electric field is determined by the temperature and/or density gradients. Therefore the structure of radial electric field and temperature and density are strongly coupled through the particle and heat transport and formation mechanism of radial electric field. Interactions between radial electric field, transport and structure in helical plasmas is discussed based on the experiments on Large Helical Device

  14. Imunologia do transtorno bipolar Immunology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Izabela Guimarães Barbosa

    2009-01-01

    Full Text Available OBJETIVO: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. MÉTODOS: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. As bases de dados avaliadas foram MedLine e Scopus, entre os anos de 1980 e 2008. RESULTADOS: Foram identificados 28 trabalhos que estudaram alterações imunes em pacientes com transtorno bipolar. Seis artigos investigaram genes relacionados à resposta imune; cinco, autoanticorpos; quatro, populações leucocitárias; 13, citocinas e/ou moléculas relacionadas à resposta imune e seis, leucócitos de pacientes in vitro. CONCLUSÕES: Embora haja evidências na literatura correlacionando o transtorno bipolar a alterações imunes, os dados não são conclusivos. O transtorno bipolar parece estar associado a níveis mais elevados de autoanticorpos circulantes, assim como à tendência à ativação imune com produção de citocinas pró-inflamatórias e redução de parâmetros anti-inflamatórios.OBJECTIVE: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. METHODS: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. RESULTS: Twenty eight works were found. Six studies investigated immune response

  15. Structural aspects of quantum field theory and noncommutative geometry

    CERN Document Server

    Grensing, Gerhard

    2013-01-01

    This book is devoted to the subject of quantum field theory. It is divided into two volumes. The first can serve as a textbook on the main techniques and results of quantum field theory, while the second treats more recent developments, in particular the subject of quantum groups and noncommutative geometry, and their interrelation. The first volume is directed at graduate students who want to learn the basic facts about quantum field theory. It begins with a gentle introduction to classical field theory, including the standard model of particle physics, general relativity, and also supergravity. The transition to quantized fields is performed with path integral techniques, by means of which the one-loop renormalization of a self-interacting scalar quantum field, of quantum electrodynamics, and the asymptotic freedom of quantum chromodynamics is treated. In the last part of the first volume, the application of path integral methods to systems of quantum statistical mechanics is covered. The book ends with a r...

  16. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

    NARCIS (Netherlands)

    Hibar, D. P.; Westlye, L. T.; Doan, N. T.; Jahanshad, N.; Cheung, J. W.; Ching, C. R. K.; Versace, A.; Bilderbeck, A. C.; Uhlmann, A.; Mwangi, B.; Krämer, B.; Overs, B.; Hartberg, C. B.; Abé, C.; Dima, D.; Grotegerd, D.; Sprooten, E.; Bøen, E.; Jimenez, E.; Howells, F. M.; Delvecchio, G.; Temmingh, H.; Starke, J.; Almeida, J. R. C.; Goikolea, J. M.; Houenou, J.; Beard, L. M.; Rauer, L.; Abramovic, L.; Bonnin, M.; Ponteduro, M. F.; Keil, M.; Rive, M. M.; Yao, N.; Yalin, N.; Najt, P.; Rosa, P. G.; Redlich, R.; Trost, S.; Hagenaars, S.; Fears, S. C.; Alonso-Lana, S.; van Erp, T. G. M.; Nickson, T.; Chaim-Avancini, T. M.; Meier, T. B.; Elvsåshagen, T.; Haukvik, U. K.; Lee, W. H.; Schene, A. H.; Lloyd, A. J.; Young, A. H.; Nugent, A.; Dale, A. M.; Pfennig, A.; McIntosh, A. M.; Lafer, B.; Baune, B. T.; Ekman, C. J.; Zarate, C. A.; Bearden, C. E.; Henry, C.; Simhandl, C.; McDonald, C.; Bourne, C.; Stein, D. J.; Wolf, D. H.; Cannon, D. M.; Glahn, D. C.; Veltman, D. J.; Pomarol-Clotet, E.; Vieta, E.; Canales-Rodriguez, E. J.; Nery, F. G.; Duran, F. L. S.; Busatto, G. F.; Roberts, G.; Pearlson, G. D.; Goodwin, G. M.; Kugel, H.; Whalley, H. C.; Ruhe, H. G.; Soares, J. C.; Fullerton, J. M.; Rybakowski, J. K.; Savitz, J.; Chaim, K. T.; Fatjó-Vilas, M.; Soeiro-de-Souza, M. G.; Boks, M. P.; Zanetti, M. V.; Otaduy, M. C. G.; Schaufelberger, M. S.; Alda, M.; Ingvar, M.; Phillips, M. L.; Kempton, M. J.; Bauer, M.; Landén, M.; Lawrence, N. S.; van Haren, N. E. M.; Horn, N. R.; Freimer, N. B.; Gruber, O.; Schofield, P. R.; Mitchell, P. B.; Kahn, R. S.; Lenroot, R.; Machado-Vieira, R.; Ophoff, R. A.; Sarró, S.; Frangou, S.; Satterthwaite, T. D.; Hajek, T.; Dannlowski, U.; Malt, U. F.; Arolt, V.; Gattaz, W. F.; Drevets, W. C.; Caseras, X.; Agartz, I.; Thompson, P. M.; Andreassen, O. A.

    2017-01-01

    Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray

  17. Simulation of Heating of an Oil-Cooled Insulated Gate Bipolar Transistors Converter Model

    National Research Council Canada - National Science Library

    Ovrebo, Gregory

    2004-01-01

    I used SolidWorks a three-dimensional modeling software, and FloWorks, a fluid dynamics analysis tool, to simulate oil flow and heat transfer in a heat sink structure attached to three insulated gate bipolar transistors...

  18. Mathematical models of bipolar disorder

    Science.gov (United States)

    Daugherty, Darryl; Roque-Urrea, Tairi; Urrea-Roque, John; Troyer, Jessica; Wirkus, Stephen; Porter, Mason A.

    2009-07-01

    We use limit cycle oscillators to model bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about 1% of the United States adult population. We consider two non-linear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using weakly-coupled, weakly-damped harmonic oscillators. We discuss how the proposed models can be used as a framework for refined models that incorporate additional biological data. We conclude with a discussion of possible generalizations of our work, as there are several biologically-motivated extensions that can be readily incorporated into the series of models presented here.

  19. String field theory-inspired algebraic structures in gauge theories

    International Nuclear Information System (INIS)

    Zeitlin, Anton M.

    2009-01-01

    We consider gauge theories in a string field theory-inspired formalism. The constructed algebraic operations lead, in particular, to homotopy algebras of the related Batalin-Vilkovisky theories. We discuss an invariant description of the gauge fixing procedure and special algebraic features of gauge theories coupled to matter fields.

  20. Surface structure of quark stars with magnetic fields

    Indian Academy of Sciences (India)

    We investigate the impact of magnetic fields on the electron distribution of the electrosphere of quark stars. For moderately strong magnetic fields of ∼ 1013 G, quantization effects are generally weak due to the large number density of electrons at surface, but can nevertheless affect the photon emission properties of quark ...

  1. Near-Field Optical Microscopy of Fractal Structures

    DEFF Research Database (Denmark)

    Coello, Victor; Bozhevolnyi, Sergey I.

    1999-01-01

    Using a photon scanning tunnelling microscope combined with a shear-force feedback system, we image both topographical and near-field optical images (at the wavelengths of 633 and 594 nm) of silver colloid fractals. Near-field optical imaging is calibrated with a standing evanescent wave pattern...

  2. Structure from the chaos: magnetic fields of cosmic objects

    Energy Technology Data Exchange (ETDEWEB)

    Krause, F

    1987-01-01

    The study deals with phenomenological and theoretical models in order to explain the existence of cosmic magnetic fields. Following aspects are considered: non-linear recursions, the theory of chaotic motions, turbulence, convection, the turbulent dynamo theory and magnetohydrodynamics. In the frame of these model assumptions it is tried to explain the causes of the solar activity cycle and the geomagnetic field.

  3. On the structure of the tail magnetic field

    International Nuclear Information System (INIS)

    Candidi, M.; Orsini, S.; Stokholm, M.; Elphic, R.C.

    1990-01-01

    The authors present a study comparing the magnetic field configuration in the magnetotail lobes with that in the plasma sheet boundary layer. The results indicate a systematic enhancement of the By component of the plasma sheet boundary layer field over that of the lobe. The value of such enhancement increases with distance from the midnight meridian plane and has the same sense in the northern and southern plasma sheet boundary layer. Such a By enhancement corresponds to a smaller rate of flaring of the magnetic field lines in the lobe with respect to the plasma sheet boundary layer. This observation is interpreted as a signature of field-aligned currents at the boundary. The direction of the field-aligned currents agrees with the nightside region 1 current system, which is the most poleward system in the nightside polar ionosphere at low altitude

  4. Effect of the ionic strength of pulsed electric field treatment medium on the physicochemical and structural characteristics of lactoferrin.

    Science.gov (United States)

    Sui, Qian; Roginski, Hubert; Williams, Roderick P W; Wooster, Tim J; Versteeg, Cornelis; Wan, Jason

    2010-11-24

    Pulsed electric field (PEF) treatment (35 kV cm(-1) for 19.2 μs using bipolar 2 μs pulses) was conducted on bovine lactoferrin (LF; 0.4 mg mL(-1)) prepared in simulated milk ultrafiltrate (SMUF), at concentrations between 0.2× and 2× normal strength, with electrical conductivities ranging from 0.17 to 1.04 S m(-1). The physicochemical and structural characteristics (LF content by a spectrophotometric and an ELISA method, surface hydrophobicity, electrophoretic mobility, far-UV circular dichroism spectra, and tryptophan fluorescence) of LF dissolved in SMUF of all strengths tested were not changed after PEF treatment. The PEF treatment of LF in 0.2 strength SMUF did not cause the release of LF-bound ferric ion into the aqueous phase, with a concentration of LF-bound iron being the same as that of the untreated LF control (174 μg L(-1)). However, in treatment media with higher ionic strengths, ferric ion was released from the LF molecule into the aqueous phase. The concentration of LF-bound iron decreased from 174 μg L(-1) for the LF treated in 0.2 strength SMUF to 80 μg L(-1) for that treated in double-strength SMUF. The results suggest that the PEF-induced iron depletion of LF does not appear to cause an appreciable conformational change in LF molecules. PEF treatment could be developed as a novel physical way to produce iron-depleted LF, as an alternative to the existing chemical method.

  5. Is bipolar always bipolar? Understanding the controversy on bipolar disorder in children

    Science.gov (United States)

    Grimmer, Yvonne; Hohmann, Sarah

    2014-01-01

    Dramatically increasing prevalence rates of bipolar disorder in children and adolescents in the United States have provoked controversy regarding the boundaries of manic symptoms in child and adolescent psychiatry. The serious impact of this ongoing debate on the treatment of affected children is reflected in the concomitant increase in prescription rates for antipsychotic medication. A key question in the debate is whether this increase in bipolar disorder in children and adolescents is based on a better detection of early-onset bipolar disorder—which can present differently in children and adolescents—or whether it is caused by an incorrect assignment of symptoms which overlap with other widely known disorders. So far, most findings suggest that the suspected symptoms, in particular chronic, non-episodic irritability (a mood symptom presenting with easy annoyance, temper tantrums and anger) do not constitute a developmental presentation of childhood bipolar disorder. Additional research based on prospective, longitudinal studies is needed to further clarify the developmental trajectories of bipolar disorder and the diagnostic status of chronic, non-episodic irritability. PMID:25580265

  6. Bipolar dislocation of the clavicle

    Directory of Open Access Journals (Sweden)

    Wei Jiang

    2012-01-01

    Full Text Available Bipolar dislocation of the clavicle at acromioclavicular and sternoclavicular joint is an uncommon traumatic injury. The conservative treatments adopted in the past is associated with redislocation dysfunction and deformity. A 41 years old lady with bipolar dislocation of right shoulder is treated surgically by open reduction and internal fixation by oblique T-plate at sternoclavicular joint and Kirschner wire stabilization at acromioclavicular joint. The patient showed satisfactory recovery with full range of motion of the right shoulder and normal muscular strength. The case reported in view of rarity and at 2 years followup.

  7. Transcultural aspects of bipolar disorder

    OpenAIRE

    Sanches, Marsal; Jorge, Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.Cultural variations in the expression of emotions have been described. Consequently, there are cross-cultural influences on the diagnosis and management o...

  8. Bipolar disorders and Wilson’s disease

    Directory of Open Access Journals (Sweden)

    Carta Mauro

    2012-05-01

    Full Text Available Abstract Background The aim of this study was to determine the risk for Bipolar Disorder (BD in Wilson’s disease (WD and to measure the impaired Quality of Life (QL in BD with WD using standardized psychiatric diagnostic tools and a case control design. Methods This was a case control study. The cases were 23 consecutive patients with WD treated at the University Hospital in Cagliari, Italy, and the controls were 92 sex- and age-matched subjects with no diagnosis of WD who were randomly selected from a database used previously for an epidemiological study. Psychiatric diagnoses according to DSM-IV criteria were determined by physicians using structured interview tools (ANTAS-SCID. QL was measured by means of SF-12. Results Compared to controls, WD patients had lower scores on the SF-12 and higher lifetime prevalence of DSM-IV major depressive disorders (OR = 5.7, 95% CI 2.4–17.3 and bipolar disorders (OR = 12.9, 95% CI 3.6–46.3. BD was associated with lower SF-12 in WD patients. Conclusions This study was the first to show an association between BD and WD using standardized diagnostic tools and a case control design. Reports in the literature about increased schizophrenia-like psychosis in WD and a lack of association with bipolar disorders may thus have been based on a more inclusive diagnosis of schizophrenia in the past. Our findings may explain the frequent reports of loss of emotional control, hyperactivity, loss of sexual inhibition, and irritability in WD patients. This study was limited by a small sample size.

  9. Effects of seed magnetic fields on magnetohydrodynamic implosion structure and dynamics

    KAUST Repository

    Mostert, W.; Wheatley, V.; Samtaney, Ravi; Pullin, D. I.

    2014-01-01

    -linearly. We fully characterize these flow structures, examine their axi- and spherisymmetry-breaking behaviour, and provide data on asymmetry evolution for different field strengths and driving pressures for each seed field configuration. We find that out

  10. Vacuum structure of the electroweak theory in high magnetic fields

    International Nuclear Information System (INIS)

    Olesen, P.

    1991-05-01

    In the electroweak theory one can reach the unbroken phase SU(2) x U y (1) by pumping enough magnetic energy into the system. The whole energy is then carried by the fields associated with U y (1), whereas the fields corresponding to SU(2) are in a vacuum state. We show that the vacuum is non-trivial in the sense that it consists of a condensate of zero-field twists which arise in a smooth way from a condensate of vortex lines existing in the broken phase. An explicit vacuum solution is constructed in terms of Weierstrass' elliptic function. (orig.)

  11. Effects of internal structure on equilibrium of field-reversed configuration plasma sustained by rotating magnetic field

    International Nuclear Information System (INIS)

    Yambe, Kiyoyuki; Inomoto, Michiaki; Okada, Shigefumi; Kobayashi, Yuka; Asai, Tomohiko

    2008-01-01

    The effects of an internal structure on the equilibrium of a field-reversed configuration (FRC) plasma sustained by rotating magnetic field is investigated by using detailed electrostatic probe measurements in the FRC Injection Experiment apparatus [S. Okada, et al., Nucl. Fusion. 45, 1094 (2005)]. An internal structure installed axially on the geometrical axis, which simulates Ohmic transformer or external toroidal field coils on the FRC device, brings about substantial changes in plasma density profile. The internal structure generates steep density-gradients not only on the inner side but on the outer side of the torus. The radial electric field is observed to sustain the ion thermal pressure-gradient in the FRC without the internal structure; however, the radial electric field is not sufficient to sustain the increased ion thermal pressure-gradient in the FRC with the internal structure. Spontaneously driven azimuthal ion flow will be accountable for the imbalance of the radial pressure which is modified by the internal structure.

  12. Cognitions in bipolar affective disorder and unipolar depression: imagining suicide.

    Science.gov (United States)

    Hales, Susie A; Deeprose, Catherine; Goodwin, Guy M; Holmes, Emily A

    2011-01-01

    Bipolar disorder has the highest rate of suicide of all the psychiatric disorders. In unipolar depression, individuals report vivid, affect-laden images of suicide or the aftermath of death (flashforwards to suicide) during suicidal ideation but this phenomenon has not been explored in bipolar disorder. Therefore the authors investigated and compared imagery and verbal thoughts related to past suicidality in individuals with bipolar disorder (n = 20) and unipolar depression (n = 20). The study used a quasi-experimental comparative design. The Structured Clinical Interview for DSM-IV was used to confirm diagnoses. Quantitative and qualitative data were gathered through questionnaire measures (e.g., mood and trait imagery use). Individual interviews assessed suicidal cognitions in the form of (i) mental images and (ii) verbal thoughts. All participants reported imagining flashforwards to suicide. Both groups reported greater preoccupation with these suicide-related images than with verbal thoughts about suicide. However, compared to the unipolar group, the bipolar group were significantly more preoccupied with flashforward imagery, rated this imagery as more compelling, and were more than twice as likely to report that the images made them want to take action to complete suicide. In addition, the bipolar group reported a greater trait propensity to use mental imagery in general. Suicidal ideation needs to be better characterized, and mental imagery of suicide has been a neglected but potentially critical feature of suicidal ideation, particularly in bipolar disorder. Our findings suggest that flashforward imagery warrants further investigation for formal universal clinical assessment procedures. © 2011 John Wiley and Sons A/S.

  13. Peak Source Power Associated with Positive Narrow Bipolar Lightning Pulses

    Science.gov (United States)

    Bandara, S. A.; Marshall, T. C.; Karunarathne, S.; Karunarathne, N. D.; Siedlecki, R. D., II; Stolzenburg, M.

    2017-12-01

    During the summer of 2016, we deployed a lightning sensor array in and around Oxford Mississippi, USA. The array system comprised seven lightning sensing stations in a network approximately covering an area of 30 km × 30 km. Each station is equipped with four sensors: Fast antenna (10 ms decay time), Slow antenna (1.0 s decay time)), field derivative sensor (dE/dt) and Log-RF antenna (bandwidth 187-192 MHz). We have observed 319 Positive NBPs and herein we report on comparisons of the NBP properties measured from the Fast antenna data with the Log-RF antenna data. These properties include 10-90% rise time, full width at half maximum, zero cross time, and range-normalized amplitude at 100 km. NBPs were categorized according to the fine structure of the electric field wave shapes into Types A-D, as in Karunarathne et al. [2015]. The source powers of NBPs in each category were determined using single station Log-RF data. Furthermore, we also categorized the NBPs in three other groups: initial event of an IC flash, isolated, and not-isolated (according to their spatiotemporal relationship with other lightning activity). We compared the source powers within each category. Karunarathne, S., T. C. Marshall, M. Stolzenburg, and N. Karunarathna (2015), Observations of positive narrow bipolar pulses, J. Geophys. Res. Atmos., 120, doi:10.1002/2015JD023150.

  14. NUMERICAL SIMULATION OF MAGNETIC FIELD STRUCTURE IN CYLINDRICAL FILM SCREEN

    Directory of Open Access Journals (Sweden)

    G. F. Gromyko

    2016-01-01

    Full Text Available A numerical method for solving the boundary value problem for a nonlinear magnetostatic equation describing the external magnetostatic field penetration through the cylindrical film coating is developed. A mathematical model of the shielding problem based on the use of the boundary conditions of the third kind on the film surface is studied. The nonlinear dependence of the film magnetic permeability on magnetic field conforms with experimental data. The distribution of the magnetic field strength in the film layer and the magnetic permeability of the film material depending on the magnitude of the external magnetic field strength are investigated numerically.

  15. Electronic monitoring in bipolar disorder.

    Science.gov (United States)

    Faurholt-Jepsen, Maria

    2018-03-01

    Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term. Moreover, electronic data could possibly represent candidate markers of diagnosis and illness activity in bipolar disorder and allow for early and individualized intervention for prodromal symptoms outside clinical settings. 
The present dissertation concerns the use of electronic monitoring as a marker and treatment intervention in bipolar disorder and investigated the scientific literature and body of evidence within the area, which includes ten original study reports and two systematic reviews, one of which included a meta-analysis, conducted by the author of the dissertation. 
Taken together, the literature presented in this dissertation illustrates that 1) smartphone-based electronic self-monitoring of mood seems to reflect clinically assessed depressive and manic symptoms and enables the long-term characterization of mood

instability in bipolar disorder; 2) preliminary results suggest that smartphone-based automatically generated data (e.g. the number of text messages sent/day; the number of incoming and outgoing calls/day; the number of changes in cell tower IDs/day; and voice features) seem to reflect clinically assessed depressive and manic symptoms in bipolar disorder; 3) smartphone-based electronic self-monitoring had no effects on the severity of depressive and manic symptoms in bipolar disorder, according to a randomized controlled trial; and 4) electronic monitoring of psychomotor

  16. Disease management apps and technical assistance systems for bipolar disorder: Investigating the patients´ point of view.

    Science.gov (United States)

    Daus, Henning; Kislicyn, Natalia; Heuer, Stephan; Backenstrass, Matthias

    2018-03-15

    Smartphone-based disease management has become increasingly interesting for research in the field of bipolar disorders. This article investigates the attitudes of persons affected by this disorder towards the appropriation of mobile apps or assistance systems for the management of their disease. We conducted two separate studies. Study 1 was an online survey with 88 participants. In study 2 we consulted 15 participants during a semi-structured interview. All the participants had formerly been diagnosed with bipolar disorder. More than half of the participants of study 1 and most participants of study 2 agreed with the use of an app or assistance system for self-ratings, third party ratings and an objective symptom monitoring. Potential interventions that were popular in both groups included a regular feedback, the visualization of monitored data and advice in crises. With study 1 we were not able to ensure correct diagnoses or to interact in a flexible way. In Study 2 those issues were resolved, but the small number of participants raises the question of a possible generalisability of the results. Furthermore, for both studies a selection bias could not be excluded. Our results indicate positive attitudes of bipolar patients towards disease management apps and assistance systems. Even new and innovative features such as partner apps or the analysis of facial expressions in video data were appreciated and daily interactions were favoured. However, the variety of answers calls for flexible systems which allow activating or deactivating certain features. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. Theoretical study of structure of electric field in helical toroidal plasmas

    International Nuclear Information System (INIS)

    Toda, S.; Itoh, K.

    2001-06-01

    A set of transport equations is analyzed, including the bifurcation of the electric field. The structure of the electric field is studied by use of the theoretical model for the anomalous transport diffusivities. The steep gradient of the electric field is obtained at the electric domain. The suppression of the anomalous transport diffusivity is studied in the presence of the strong shear of the electric field. The hard transition with the multiple ambipolar solutions is examined in the structure of the radial electric field. The details of the structure of the electric domain interface are investigated. (author)

  18. FIRST SIMULTANEOUS DETECTION OF MOVING MAGNETIC FEATURES IN PHOTOSPHERIC INTENSITY AND MAGNETIC FIELD DATA

    International Nuclear Information System (INIS)

    Lim, Eun-Kyung; Yurchyshyn, Vasyl; Goode, Philip

    2012-01-01

    The formation and the temporal evolution of a bipolar moving magnetic feature (MMF) was studied with high-spatial and temporal resolution. The photometric properties were observed with the New Solar Telescope at Big Bear Solar Observatory using a broadband TiO filter (705.7 nm), while the magnetic field was analyzed using the spectropolarimetric data obtained by Hinode. For the first time, we observed a bipolar MMF simultaneously in intensity images and magnetic field data, and studied the details of its structure. The vector magnetic field and the Doppler velocity of the MMF were also studied. A bipolar MMF with its positive polarity closer to the negative penumbra formed, accompanied by a bright, filamentary structure in the TiO data connecting the MMF and a dark penumbral filament. A fast downflow (≤2 km s –1 ) was detected at the positive polarity. The vector magnetic field obtained from the full Stokes inversion revealed that a bipolar MMF has a U-shaped magnetic field configuration. Our observations provide a clear intensity counterpart of the observed MMF in the photosphere, and strong evidence of the connection between the MMF and the penumbral filament as a serpentine field.

  19. The second phase of bipolar, nanosecond-range electric pulses determines the electroporation efficiency.

    Science.gov (United States)

    Pakhomov, Andrei G; Grigoryev, Sergey; Semenov, Iurii; Casciola, Maura; Jiang, Chunqi; Xiao, Shu

    2018-03-29

    Bipolar cancellation refers to a phenomenon when applying a second electric pulse reduces ("cancels") cell membrane damage by a preceding electric pulse of the opposite polarity. Bipolar cancellation is a reason why bipolar nanosecond electric pulses (nsEP) cause weaker electroporation than just a single unipolar phase of the same pulse. This study was undertaken to explore the dependence of bipolar cancellation on nsEP parameters, with emphasis on the amplitude ratio of two opposite polarity phases of a bipolar pulse. Individual cells (CHO, U937, or adult mouse ventricular cardiomyocytes (VCM)) were exposed to either uni- or bipolar trapezoidal nsEP, or to nanosecond electric field oscillations (NEFO). The membrane injury was evaluated by time-lapse confocal imaging of the uptake of propidium (Pr) or YO-PRO-1 (YP) dyes and by phosphatidylserine (PS) externalization. Within studied limits, bipolar cancellation showed little or no dependence on the electric field intensity, pulse repetition rate, chosen endpoint, or cell type. However, cancellation could increase for larger pulse numbers and/or for longer pulses. The sole most critical parameter which determines bipolar cancellation was the phase ratio: maximum cancellation was observed with the 2nd phase of about 50% of the first one, whereas a larger 2nd phase could add a damaging effect of its own. "Swapping" the two phases, i.e., delivering the smaller phase before the larger one, reduced or eliminated cancellation. These findings are discussed in the context of hypothetical mechanisms of bipolar cancellation and electroporation by nsEP. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. Social support and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Paula Mendonça Studart

    2015-08-01

    Full Text Available Background Bipolar disorder is a chronic condition that affects the functioning of its carriers in many different ways, even when treated properly. Therefore, it’s also important to identify the psychosocial aspects that could contribute to an improvement of this population’s quality of life.Objective Carry out a literature review on the role of social support in cases of bipolar disorder.Method A research on the following online databases PubMed, Lilacs and SciELO was conducted by using the keywords “social support” or “social networks” and “mood disorders” or “bipolar disorder” or “affective disorder,” with no defined timeline.Results Only 13 studies concerning the topic of social support and BD were found in the search for related articles. Generally speaking, the results show low rates of social support for BD patients.Discussion Despite the growing interest in the overall functioning of patients with bipolar disorder, studies on social support are still rare. Besides, the existing studies on the subject use different methodologies, making it difficult to establish data comparisons.

  1. Electronic monitoring in bipolar disorder

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, Maria

    2018-01-01

    generated data (e.g. the number of text messages sent/day; the number of incoming and outgoing calls/day; the number of changes in cell tower IDs/day; and voice features) seem to reflect clinically assessed depressive and manic symptoms in bipolar disorder; 3) smartphone-based electronic self-monitoring had...

  2. Evolution of the magnetic field structure of the Crab pulsar.

    Science.gov (United States)

    Lyne, Andrew; Graham-Smith, Francis; Weltevrede, Patrick; Jordan, Christine; Stappers, Ben; Bassa, Cees; Kramer, Michael

    2013-11-01

    Pulsars are highly magnetized rotating neutron stars and are well known for the stability of their signature pulse shapes, allowing high-precision studies of their rotation. However, during the past 22 years, the radio pulse profile of the Crab pulsar has shown a steady increase in the separation of the main pulse and interpulse components at 0.62° ± 0.03° per century. There are also secular changes in the relative strengths of several components of the profile. The changing component separation indicates that the axis of the dipolar magnetic field, embedded in the neutron star, is moving toward the stellar equator. This evolution of the magnetic field could explain why the pulsar does not spin down as expected from simple braking by a rotating dipolar magnetic field.

  3. Progressive neurostructural changes in adolescent and adult patients with bipolar disorder.

    Science.gov (United States)

    Lisy, Megan E; Jarvis, Kelly B; DelBello, Melissa P; Mills, Neil P; Weber, Wade A; Fleck, David; Strakowski, Stephen M; Adler, Caleb M

    2011-06-01

    Several lines of evidence suggest that bipolar disorder is associated with progressive changes in gray matter volume (GMV), particularly in brain structures involved in emotional regulation and expression. The majority of these studies however, have been cross-sectional in nature. In this study we compared baseline and follow-up scans in groups of bipolar disorder and healthy subjects. We hypothesized bipolar disorder subjects would demonstrate significant GMV changes over time. A total of 58 bipolar disorder and 48 healthy subjects participated in structural magnetic resonance imaging (MRI). Subjects were rescanned 3-34 months after their baseline MRI. MRI images were segmented, normalized to standard stereotactic space, and compared voxel-by-voxel using statistical parametrical mapping software (SPM2). A model was developed to investigate differences in GMV at baseline, and associated with time and episodes, as well as in comparison to healthy subjects. We observed increases in GMV in bipolar disorder subjects across several brain regions at baseline and over time, including portions of the prefrontal cortex as well as limbic and subcortical structures. Time-related changes differed to some degree between adolescent and adult bipolar disorder subjects. The interval between scans positively correlated with GMV increases in bipolar disorder subjects in portions of the prefrontal cortex, and both illness duration and number of depressive episodes were associated with increased GMV in subcortical and limbic structures. Our findings support suggestions that widely observed progressive neurofunctional changes in bipolar disorder patients may be related to structural brain abnormalities in anterior limbic structures. Abnormalities largely involve regions previously noted to be integral to emotional expression and regulation, and appear to vary by age. © 2011 John Wiley and Sons A/S.

  4. Nelson's stochastic quantization of free linearized gravitational field and its Markovian structure

    International Nuclear Information System (INIS)

    Lim, S.C.

    1983-05-01

    It is shown that by applying Nelson's stochastic quantization scheme to free linearized gravitational field tensor one can associate with the resulting stochastic system a stochastic tensor field which coincides with the ''space'' part of the Riemannian tensor in Euclidean space-time. However, such a stochastic field fails to satisfy the Markov property. Instead, it satisfies the reflection positivity. The Markovian structure of the stochastic fields associated with the electromagnetic field is also discussed. (author)

  5. Eigenmode field structure of the fast magnetosonic wave in a Tokamak and loading impedance of coupling structures

    International Nuclear Information System (INIS)

    Adam, J.; Jacquinot, J.

    1977-04-01

    Detailed calculations concerning the field structure and excitation of the fast magnetosonic wave are presented keeping in mind RF heating of a Tokamak near the ion cyclotron harmonic. The new contributions are - a discussion of the cylindrical problem in an inhomogeneous plasma including surface waves and the splitting of the eigenmodes by the poloidal field - a calculation of the field structure in the toroidal cavity resonator and the application to mode tracking - a formulation of the loading impedance of various coupling structures: array of coils in the low frequency limit or transmission lines in the high frequency case

  6. Molecular-Field Calculation of the Magnetic Structure in Erbium

    DEFF Research Database (Denmark)

    Jensen, J.

    1976-01-01

    A molecular-field calculation of the magnetic configurations in Er is found to reproduce the neutron diffraction results of the three different magnetic phases and to give a reasonable fit to the magnetization data at 4.2K. The two-ion coupling is considered to be described by the inter......-planar coupling parameters deduced from the dispersion of the spin waves in the low temperature conical phases. The four (effective) crystal-field parameters are determined by the fit to the experimental data. Projecting the magnetic moments present in the intermediate phase of Er (18-52.4K) to a common origin...

  7. A new structure for a superconducting field effect transistor

    International Nuclear Information System (INIS)

    Tyc, S.; Schuhl, A.

    1992-01-01

    In this paper a new structure is proposed and described which can solve the most severe drawbacks of current architectures for Josephson FETs. Its advantages are discussed, and several realizations are suggested

  8. A prospective study of diagnostic conversion of major depressive disorder to bipolar disorder in pregnancy and postpartum.

    Science.gov (United States)

    Sharma, Verinder; Xie, Bin; Campbell, M Karen; Penava, Debbie; Hampson, Elizabeth; Mazmanian, Dwight; Pope, Carley J

    2014-02-01

    The aim of the present study was to determine the rate of, and risk factors for, a change in diagnosis from major depressive disorder to bipolar disorder, and from bipolar II disorder to bipolar I disorder in pregnancy and postpartum. Patients with a prior history of major depressive disorder or bipolar II disorder were recruited between 24 and 28 weeks' gestation and followed through to one year postpartum. Diagnostic interviews were conducted using the Structured Clinical Interview for DSM-IV at study intake and repeated using the Mini-International Psychiatric Interview at one, three, six, and 12 months after childbirth. Fisher's exact test was used to assess the association between various risk factors and diagnostic switch. A total of 146 participants completed the intake interview and at least one follow-up interview postpartum. Of these, 92 were diagnosed with major depressive disorder and 54 with bipolar II disorder at intake. Six women (6.52%) experienced a diagnostic change from major depressive disorder to bipolar II disorder during the first six months after childbirth. There were no cases of switching to bipolar I disorder, but in one participant the diagnosis changed from bipolar II disorder to bipolar I disorder during the three months after childbirth. Bipolar switch was associated with a family history of bipolar disorder. The postpartum period appears to be a time of high risk for a new onset of hypomania in women with major depressive disorder. Our rate of diagnostic switching to bipolar II disorder (6.52%) is at least 11- to 18-fold higher than the rates of switching in similar studies conducted in both men and women. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Electropermeabilization by uni- or bipolar nanosecond electric pulses: The impact of extracellular conductivity.

    Science.gov (United States)

    Gianulis, Elena C; Casciola, Maura; Xiao, Shu; Pakhomova, Olga N; Pakhomov, Andrei G

    2018-02-01

    Cellular effects caused by nanosecond electric pulses (nsEP) can be reduced by an electric field reversal, a phenomenon known as bipolar cancellation. The reason for this cancellation effect remains unknown. We hypothesized that assisted membrane discharge is the mechanism for bipolar cancellation. CHO-K1 cells bathed in high (16.1mS/cm; HCS) or low (1.8mS/cm; LCS) conductivity solutions were exposed to either one unipolar (300-ns) or two opposite polarity (300+300-ns; bipolar) nsEP (4-40kV/cm) with increasing interpulse intervals (0.1-50μs). Time-lapse YO-PRO-1 (YP) uptake revealed enhanced membrane permeabilization in LCS compared to HCS at all tested voltages. The time-dependence of bipolar cancellation was similar in both solutions, using either identical (22kV/cm) or isoeffective nsEP treatments (12 and 32kV/cm for LCS and HCS, respectively). However, cancellation was significantly stronger in LCS when the bipolar nsEP had no, or very short (bipolar cancellation was still present with interpulse intervals as long as 50μs, beyond the time expected for membrane discharge. Our findings do not support assisted membrane discharge as the mechanism for bipolar cancellation. Instead they exemplify the sustained action of nsEP that can be reversed long after the initial stimulus. Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Force Structure Matters: The US Field Artillery in Operational Art

    Science.gov (United States)

    2015-05-23

    2003 (Fort Sill, OK: US Army Field Artillery Center, 2004), 62-63. 3 Sean Bateman and Steven Hady, “King of Battle Once Again: An Organizational...To What Ends Military Power?” International Security 4, no. 4 (Spring 1980): 3- 35. Bateman , Sean and Steven Hady. “King of Battle Once Again: An

  11. Learning color receptive fields and color differential structure

    NARCIS (Netherlands)

    ter Haar Romenij, B.M.

    2016-01-01

    In this paper we study the role of brain plasticity, and investigate the emergence and self-emergence of receptive fields from scalar and color natural images by principal component analysis of image patches. We describe the classical experiment on localized PCA on center-surround weighted patches

  12. Algebraic structure of cohomological field theory models and equivariant cohomology

    International Nuclear Information System (INIS)

    Stora, R.; Thuillier, F.; Wallet, J.Ch.

    1994-01-01

    The definition of observables within conventional gauge theories is settled by general consensus. Within cohomological theories considered as gauge theories of an exotic type, that question has a much less obvious answer. It is shown here that in most cases these theories are best defined in terms of equivariant cohomologies both at the field level and at the level of observables. (author). 21 refs

  13. Conformal field theory between supersymmetry and indecomposable structures

    Energy Technology Data Exchange (ETDEWEB)

    Eberle, H.

    2006-07-15

    This thesis considers conformal field theory in its supersymmetric extension as well as in its relaxation to logarithmic conformal field theory. This thesis is concerned with the subspace of K3 compactifications which is not well known yet. In particular, we inspect the intersection point of the Z{sub 2} and Z{sub 4} orbifold subvarieties within the K3 moduli space, explicitly identify the two corresponding points on the subvarieties geometrically, and give an explicit isomorphism of the three conformal field theory models located at that point, a specific Z{sub 2} and Z{sub 4} orbifold model as well as the Gepner model (2){sup 4}. We also prove the orthogonality of the two subvarieties at the intersection point. This is the starting point for the programme to investigate generic points in K3 moduli space. We use the coordinate identification at the intersection point in order to relate the coordinates of both subvarieties and to explicitly calculate a geometric geodesic between the two subvarieties as well as its generator. A generic point in K3 moduli space can be reached by such a geodesic originating at a known model. We also present advances on the conformal field theoretic side of deformations along such a geodesic using conformal deformation theory. Moreover, we regard a relaxation of conformal field theory to logarithmic conformal field theory. In particular, we study general augmented c{sub p,q} minimal models which generalise the well-known (augmented) c{sub p,1} model series. We calculate logarithmic nullvectors in both types of models. But most importantly, we investigate the low lying Virasoro representation content and fusion algebra of two general augmented c{sub p,q} models, the augmented c{sub 2,3}=0 model as well as the augmented Yang-Lee model at c{sub 2,5}=-22/5. In particular, the true vacuum representation is rather given by a rank 1 indecomposable but not irreducible subrepresentation of a rank 2 representation. We generalise these generic

  14. Conformal field theory between supersymmetry and indecomposable structures

    International Nuclear Information System (INIS)

    Eberle, H.

    2006-07-01

    This thesis considers conformal field theory in its supersymmetric extension as well as in its relaxation to logarithmic conformal field theory. This thesis is concerned with the subspace of K3 compactifications which is not well known yet. In particular, we inspect the intersection point of the Z 2 and Z 4 orbifold subvarieties within the K3 moduli space, explicitly identify the two corresponding points on the subvarieties geometrically, and give an explicit isomorphism of the three conformal field theory models located at that point, a specific Z 2 and Z 4 orbifold model as well as the Gepner model (2) 4 . We also prove the orthogonality of the two subvarieties at the intersection point. This is the starting point for the programme to investigate generic points in K3 moduli space. We use the coordinate identification at the intersection point in order to relate the coordinates of both subvarieties and to explicitly calculate a geometric geodesic between the two subvarieties as well as its generator. A generic point in K3 moduli space can be reached by such a geodesic originating at a known model. We also present advances on the conformal field theoretic side of deformations along such a geodesic using conformal deformation theory. Moreover, we regard a relaxation of conformal field theory to logarithmic conformal field theory. In particular, we study general augmented c p,q minimal models which generalise the well-known (augmented) c p,1 model series. We calculate logarithmic nullvectors in both types of models. But most importantly, we investigate the low lying Virasoro representation content and fusion algebra of two general augmented c p,q models, the augmented c 2,3 =0 model as well as the augmented Yang-Lee model at c 2,5 =-22/5. In particular, the true vacuum representation is rather given by a rank 1 indecomposable but not irreducible subrepresentation of a rank 2 representation. We generalise these generic examples to give the representation content and

  15. Alternative bipolar plates design and manufacturing for PEM fuel cell

    International Nuclear Information System (INIS)

    Lee Chang Chuan; Norhamidi Muhamad; Jaafar Sahari

    2006-01-01

    Bipolar plates is one of the important components in fuel cell stack, it comprise up to 80% of the stack volume. Traditionally, these plates have been fabricated from graphite, owing to its chemical nobility, and high electrical and thermal conductivity; but these plates are brittle and relatively thick. Therefore increasing the stack volume and size. Alternatives to graphite are carbon-carbon composite, carbon-polymer composite and metal (aluminum, stainless steel, titanium and nickel based alloy). The use of coated and uncoated metal bipolar plates has received attention recently due to the simplicity of plate manufacturing. The thin nature of the metal substrate allows for smaller stack design with reduced weight. Lightweight coated metals as alternative to graphite plate is being developed. Beside the traditional method of machining and slurry molding, metal foam for bipolar plates fabrication seems to be a good alternative. The plates will be produced with titanium powder by Powder Metallurgy method using space holders technique to produce the meal foam flow-field. This work intends to facilitate the materials and manufacturing process requirements to produce cost effective foamed bipolar plates for fuel cell

  16. Self-organization of physical fields and spin

    International Nuclear Information System (INIS)

    Pestov, I.B.

    2008-01-01

    The subject of the present investigation is the laws of intrinsic self-organization of fundamental physical fields. In the framework of the Theory of Self-Organization the geometrical and physical nature of spin phenomena is uncovered. The key points are spin symmetry (the fundamental realization of the concept of geometrical internal symmetry) and the spinning field (space of defining representation of spin symmetry). It is shown that the essence of spin is the bipolar structure of spin symmetry induced by the gravitational potentials. The bipolar structure provides natural violation of spin symmetry and leads to spinstatics (theory of spinning field outside the time) and spindynamics. The equations of spinstatics and spindynamics are derived. It is shown that Sommerfeld's formula can be derived from the equations of spindynamics and hence the correspondence principle is valid. This means that the Theory of Self-Organization provides the new understanding of spin phenomena

  17. Chiral effective-field theory of the nucleon spin structure

    Science.gov (United States)

    Pascalutsa, Vladimir

    2017-01-01

    I will review the recent chiral EFT calculations of the nucleon (spin) structure functions at low Q2, confronted with the Jefferson Lab measurements. The moments of the structure functions correspond with various polarizabilities, and I will explain why one of them - δLT - is especially interesting. I will also discuss how the spin structure functions at low Q enter in the atomic calculations of the hyperfine splittings and how they are impacting the ongoing experimental program at PSI (Switzerland) to measure the ground-state hyperfine splitting of muonic hydrogen. Partially supported by the Deutsche Forschungsgemeinschaft (DFG) through the Collaborative Research Center SFB 1044 [The Low-Energy Frontier of the Standard Model].

  18. High Field Studies for CLIC Accelerating Structures Development

    CERN Document Server

    Profatilova, I

    2017-01-01

    Compact Linear Collider RF structures need to be able to achieve the very high average accelerating gradient of 100 MV/m. One of the main challenges in reaching such high accelerating gradients is to avoid vacuum electrical breakdown within CLIC accelerating structures. Accelerating structure tests are carried out in the klystron-based test stands known as the XBoxes. In order to investigate vacuum breakdown phenomena and its statistical characteristics in a simpler system and get results in a faster way, pulsed dc systems have been developed at CERN. To acquire sufficient breakdown data in a reasonable period of time, high repetition rate pulse generators are used in the systems for breakdown studies, so-called pulsed dc system. This paper describes the pulsed dc systems and the two high repetition rate circuits, which produce high-voltage pulses for it, available at CERN.

  19. The Field of Foucaultian Discourse Analysis: Structures, Developments and Perspectives

    Directory of Open Access Journals (Sweden)

    Rainer Diaz-Bone

    2007-05-01

    Full Text Available The article outlines the field of FOUCAULTian discourse analysis. The FOUCAULTian concept of discourse is introduced, and methodological positions and methodological developments are sketched. Compared to other qualitative social research approaches, the different researchers and research groups that have adopted the FOUCAULTian concept of discourse are not linked by a fully integrated common research paradigm. However, they share common methodological problems and areas of methodological research resulting from various references to FOUCAULTian positions. In the last decade, different research groups have become aware of these shared commonalities, so that one can speak of an emerging field of FOUCAULTian discourse analysis rather than an emerging paradigm. The article gives insight into the discourse analytic research in selected countries, discusses the internationalisation of FOUCAULTian discourse analysis and highlights current trends and perspectives. URN: urn:nbn:de:0114-fqs0702305

  20. Gravity field and internal structure of Mercury from MESSENGER.

    Science.gov (United States)

    Smith, David E; Zuber, Maria T; Phillips, Roger J; Solomon, Sean C; Hauck, Steven A; Lemoine, Frank G; Mazarico, Erwan; Neumann, Gregory A; Peale, Stanton J; Margot, Jean-Luc; Johnson, Catherine L; Torrence, Mark H; Perry, Mark E; Rowlands, David D; Goossens, Sander; Head, James W; Taylor, Anthony H

    2012-04-13

    Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/MR(2) = 0.353 ± 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(m)/C = 0.452 ± 0.035. A model for Mercury's radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core.

  1. Structure of the magnetic field line diversion in Helias configurations

    International Nuclear Information System (INIS)

    Strumberger, E.

    1991-01-01

    The vacuum magnetic field outside the last closed magnetic surface of Helias configurations is investigated with respect to its field line diversion properties. In a Helias configuration with N periods N half-helix like edges run on the toroidally outward side of the plasma boundary and yield the possibility of separatrix formation due to the coincidence of helical edge and x-points between islands. With the choice N=5, and ι=1 at the plasma boundary, there are five magnetic islands outside the last closed magnetic surface. In the case considered, islands are lying in front of the helical edge at the beginning, in the middle and at the end of this edge, while in positions in between x-points are in front of the helical edge. (author) 3 refs., 5 figs

  2. New foundations for applied electromagnetics the spatial structure of fields

    CERN Document Server

    Mikki, Said

    2016-01-01

    This comprehensive new resource focuses on applied electromagnetics and takes readers beyond the conventional theory with the use of contemporary mathematics to improve the practical use of electromagnetics in emerging areas of field communications, wireless power transfer, metamaterials, MIMO and direction-of-arrival systems. The book explores the existing and novel theories and principles of electromagnetics in order to help engineers analyze and design devices for todays applications in wireless power transfers, NFC, and metamaterials.

  3. The bipolar silicon microstrip detector: A proposal for a novel precision tracking device

    International Nuclear Information System (INIS)

    Horisberger, R.

    1990-01-01

    It is proposed to combine the technology of fully depleted microstrip detectors fabricated on n doped high resistivity silicon with the concept of the bipolar transistor. This is done by adding a n ++ doped region inside the normal p + implanted region of the reverse biased p + n diode. The resulting structure has amplifying properties and is referred to as bipaolar pixel transistor. The simplest readout scheme of a bipolar pixel array by an aluminium strip bus leads to the bipolar microstrip detector. The bipolar pixel structure is expected to give a better signal-to-noise performance for the detection of minimum ionizing charged particle tracks than the normal silicon diode strip detector and therefore should allow in future the fabrication of thinner silicon detectors for precision tracking. (orig.)

  4. A 680 V LDMOS on a thin SOI with an improved field oxide structure and dual field plate

    International Nuclear Information System (INIS)

    Wang Zhongjian; Cheng Xinhong; Xia Chao; Xu Dawei; Cao Duo; Song Zhaorui; Yu Yuehui; Shen Dashen

    2012-01-01

    A 680 V LDMOS on a thin SOI with an improved field oxide (FOX) and dual field plate was studied experimentally. The FOX structure was formed by an 'oxidation-etch-oxidation' process, which took much less time to form, and had a low protrusion profile. A polysilicon field plate extended to the FOX and a long metal field plate was used to improve the specific on-resistance. An optimized drift region implant for linear-gradient doping was adopted to achieve a uniform lateral electric field. Using a SimBond SOI wafer with a 1.5 μm top silicon and a 3 μm buried oxide layer, CMOS compatible SOI LDMOS processes are designed and implemented successfully. The off-state breakdown voltage reached 680 V, and the specific on-resistance was 8.2 Ω·mm 2 . (semiconductor devices)

  5. Use of bipolar radiofrequency catheter ablation in treatment of cardiac arrhythmias.

    Science.gov (United States)

    Soucek, Filip; Starek, Zdenek

    2018-05-23

    Background Arrhythmia management is a complex process involving both pharmacological and non-pharmacological approaches. Radiofrequency ablation is the pillar of non-pharmacological arrhythmia treatment. Unipolar ablation is considered to be the gold standard in the treatment of the majority of arrhythmias; however, its efficacy is limited to specific cases. In particular, the creation of deep or transmural lesions to eliminate intramurally originating arrhythmias remains inadequate. Bipolar ablation is proposed as an alternative to overcome unipolar ablation boundaries. Results Despite promising results gained from in vitro and animal studies showing that bipolar ablation is superior in creating transmural lesions, the use of bipolar ablation in daily clinical practice is limited. Several studies have been published showing that bipolar ablation is effective in the treatment of clinical arrhythmias after failed unipolar ablation, however there is inconsistency regarding safety of bipolar ablation within the available research papers. According to research evidence the most common indications for bipolar ablation use are ventricular originating rhythmic disorders in patients with structural heart disease resistant to standard radiofrequency ablation. Conclusions To allow wider clinical application the efficiency and safety of bipolar ablation need to be verified in future studies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Normal pituitary volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study.

    Science.gov (United States)

    Chen, Hua Hsuan; Nicoletti, Mark; Sanches, Marsal; Hatch, John P; Sassi, Roberto B; Axelson, David; Brambilla, Paolo; Keshavan, Matcheri S; Ryan, Neal; Birmaher, Boris; Soares, Jair C

    2004-01-01

    The volume of the pituitary gland in adults with bipolar disorder has previously been reported to be smaller than that of healthy controls. Such abnormalities would be consistent with the HPA dysfunction reported in this illness. We conducted a study of children and adolescents with bipolar disorder to determine whether size abnormalities in the pituitary gland are already present early in illness course. Magnetic resonance imaging (MRI) morphometric analysis of the pituitary gland was carried out in 16 DSM-IV children and adolescents with bipolar disorder (mean age+/-sd=15.5+/-3.4 years) and 21 healthy controls (mean age+/-sd=16.9+/-3.8 years). Subjects underwent a 1.5 T MRI, with 3-D Spoiled Gradient Recalled (SPGR) acquisition. There was no statistically significant difference between pituitary gland volumes of bipolar patients compared to healthy controls (ANCOVA, age, gender, and ICV as covariates; F=1.77, df=1,32, P=.19). There was a statistically significant direct relationship between age and pituitary gland volume in both groups (r=.59, df=17, P=.007 for healthy controls; r=.61, df=12, P=.008 for bipolar patients). No evidence of size abnormalities in the pituitary gland was found in child and adolescent bipolar patients, contrary to reports involving adult bipolar patients. This suggests that anatomical abnormalities in this structure may develop later in illness course as a result of continued HPA dysfunction. (c) 2005 Wiley-Liss, Inc.

  7. Gray Matter Volume Decrease Distinguishes Schizophrenia From Bipolar Offspring During Childhood and Adolescence.

    Science.gov (United States)

    Sugranyes, Gisela; de la Serna, Elena; Romero, Soledad; Sanchez-Gistau, Vanessa; Calvo, Anna; Moreno, Dolores; Baeza, Inmaculada; Diaz-Caneja, Covadonga M; Sanchez-Gutierrez, Teresa; Janssen, Joost; Bargallo, Nuria; Castro-Fornieles, Josefina

    2015-08-01

    There is increasing support toward the notion that schizophrenia and bipolar disorder share neurodevelopmental underpinnings, although areas of divergence remain. We set out to examine gray matter volume characteristics of child and adolescent offspring of patients with schizophrenia or bipolar disorder comparatively. In this 2-center study, magnetic resonance structural neuroimaging data were acquired in 198 children and adolescents (aged 6-17 years): 38 offspring of patients with schizophrenia, 77 offspring of patients with bipolar disorder, and 83 offspring of community controls. Analyses of global brain volumes and voxel-based morphometry (using familywise error correction) were conducted. There was an effect of group on total cerebral gray matter volume (F = 3.26, p = .041), driven by a decrease in offspring of patients with schizophrenia relative to offspring of controls (p = .035). At a voxel-based level, we observed an effect of group in the left inferior frontal cortex/anterior insula (F = 14.7, p bipolar disorder (p bipolar disorder and offspring of controls in either global or voxel-based gray matter volumes. This first comparative study between offspring of patients with schizophrenia and bipolar disorder suggests that gray matter volume reduction in childhood and adolescence may be specific to offspring of patients with schizophrenia; this may index a greater neurodevelopmental impact of risk for schizophrenia relative to bipolar disorder during youth. Copyright © 2015 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

  8. Seasonal changes, sleep length and circadian preference among twins with bipolar disorder

    Directory of Open Access Journals (Sweden)

    Koskenvuo Markku

    2003-06-01

    Full Text Available Abstract Background We aimed at studying the seasonal changes in mood and behaviour, the distribution of hospital admissions by season, and the persistence of the circadian type in twins with bipolar disorder and their healthy co-twins. Methods All Finnish like-sex twins born from 1940 to 1969 were screened for a diagnosis of bipolar type I disorder. The diagnosis was assessed with a structured research interview, and the study subjects (n = 67 filled in the Seasonal Pattern Assessment Questionnaire (SPAQ and the Morningness-Eveningness Questionnaire (MEQ. For studying the persistence of the habitual sleep length and circadian type, we used data derived from the Finnish Twin Cohort Questionnaire (FTCQ. Bipolar twins were compared with their healthy co-twins. Results Bipolar twins had greater seasonal changes in sleep length (p = 0.01 and mood (p = 0.01, and higher global seasonality scores (p = 0.03 as compared with their co-twins with no mental disorder. Sunny days (p = 0.03 had a greater positive effect on wellbeing in the bipolar than healthy co-twins. Conclusions Our results support the view that bipolar disorder is sensitive to the environmental influence in general and to the seasonal effect in specific. Exposure to natural light appears to have a substantial effect on wellbeing in twins with bipolar disorder.

  9. Structural Mapping Based on Potential Field and Remote Sensing ...

    Indian Academy of Sciences (India)

    52

    exploration program sponsored by oil industries (Bijendra Singh et al. 2009). G-M surveys revealed ... structural details of the basin architecture in order to comprehend the tectonic development of the basin. In this endeavor, we have utilized ..... increasing frequency (Spector and Grant 1970). In this approach, depth to the ...

  10. Braided structure in 4-dimensional conformal quantum field theory

    International Nuclear Information System (INIS)

    Schroer, Bert

    2001-03-01

    Higher dimensional conformal QFT possesses an intersting braided structure which different from the d=1+1 models, is restricted to the timelike region and therefore easily escapes euclidean action methods. It lies behind the spectrum of anamalous which may be viewed as a kind of substitute for a missing particle interpretation in the presence of interactions. (author)

  11. Genetic Relationships Between Schizophrenia, Bipolar Disorder, and Schizoaffective Disorder

    Science.gov (United States)

    Cardno, Alastair G.

    2014-01-01

    There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6. Results of genome-wide association studies are consistent with commonly occurring genetic risk variants, contributing to both the shared and nonshared aspects, while studies of large, rare chromosomal structural variants, particularly copy number variants, show a stronger influence on schizophrenia than bipolar disorder to date. Schizoaffective disorder has been less investigated but shows substantial familial overlap with both schizophrenia and bipolar disorder. A twin analysis is consistent with genetic influences on schizoaffective episodes being entirely shared with genetic influences on schizophrenic and manic episodes, while association studies suggest the possibility of some relatively specific genetic influences on broadly defined schizoaffective disorder, bipolar subtype. Further insights into genetic relationships between these disorders are expected as studies continue to increase in sample size and in technical and analytical sophistication, information on phenotypes beyond clinical diagnoses are increasingly incorporated, and approaches such as next-generation sequencing identify additional types of genetic risk variant. PMID:24567502

  12. Prevention of brittle fracture of steel structures by controlling the local stress and strain fields

    Directory of Open Access Journals (Sweden)

    Moyseychik Evgeniy Alekseevich

    Full Text Available In the article the author offers a classification of the methods to increase the cold resistance of steel structural shapes with a focus on the regulation of local fields of internal stresses and strains to prevent brittle fracture of steel structures. The need of a computer thermography is highlighted not only for visualization of temperature fields on the surface, but also to control the fields of residual stresses and strains in a controlled element.

  13. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder

    NARCIS (Netherlands)

    Wiste, Anna; Robinson, Elise B.; Milaneschi, Yuri; Meier, Sandra; Ripke, Stephan; Clements, Caitlin C.; Fitzmaurice, Garrett M.; Rietschel, Marcella; Penninx, Brenda W.; Smoller, Jordan W.; Perlis, Roy H.

    Objectives Family and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation. Methods A polygenic risk score for bipolar disorder,

  14. Spinors in euclidean field theory, complex structures and discrete symmetries

    International Nuclear Information System (INIS)

    Wetterich, C.

    2011-01-01

    We discuss fermions for arbitrary dimensions and signature of the metric, with special emphasis on euclidean space. Generalized Majorana spinors are defined for d=2,3,4,8,9mod8, independently of the signature. These objects permit a consistent analytic continuation of Majorana spinors in Minkowski space to euclidean signature. Compatibility of charge conjugation with complex conjugation requires for euclidean signature a new complex structure which involves a reflection in euclidean time. The possible complex structures for Minkowski and euclidean signature can be understood in terms of a modulo two periodicity in the signature. The concepts of a real action and hermitean observables depend on the choice of the complex structure. For a real action the expectation values of all hermitean multi-fermion observables are real. This holds for arbitrary signature, including euclidean space. In particular, a chemical potential is compatible with a real action for the euclidean theory. We also discuss the discrete symmetries of parity, time reversal and charge conjugation for arbitrary dimension and signature.

  15. A new support structure for high field magnets

    International Nuclear Information System (INIS)

    Bish, P.S.; Caspi, S.; Dietderich, D.R.; Gourlay, S.A.; Hafalia, R.R.; Hannaford, R.; Lietzke, A.F.; Liggins, N.; McInturff, A.D.; Sabbi, G.L.; Scanlan, R.M.; O'Neill, J.; Swanson, J.H

    2001-01-01

    Pre-stress of superconducting magnets can be applied directly through the magnet yoke structure. We have replaced the collar functionality in our 14 Tesla R and D Nb 3 Sn dipole magnets with an assembly procedure based on an aluminum shell and bladders. Bladders, placed between the coil pack and surrounding yoke inside the shell, are pressurized up to 10 ksi [70 MPa] to create an interference gap. Keys placed into the interference gap replace the bladder functionality. Following the assembly, the bladders are deflated and removed. Strain gauges mounted directly on the shell are used to monitor the stress of the entire magnet structure, thereby providing a high degree of pre-stress control without the need for high tolerances. During assembly, a force of 8.2 x 10 5 lbs/ft [12 MN/m] is generated by the bladders and the stress in the 1.57 inch [40mm] aluminum shell reaches 20.3 ksi [140 MPa]. During cool-down the thermal expansion difference between shell and yoke generates an additional compressive force of 6.85 x 10 5 lbs/ft [10 MN/m], corresponding to a final stress in the shell of 39.2 ksi [270 MPa]. Pre-stress conditions are sufficient for 16 T before the coils separate at the bore. Bladders have now been used in the assembly and disassembly of two 14 T magnets. This paper describes the magnet structure, assembly procedure and test results

  16. Improved Flow-Field Structures for Direct Methanol Fuel Cells

    Energy Technology Data Exchange (ETDEWEB)

    Gurau, Bogdan [Nuvant Systems Inc., Crown Point, IN (United States)

    2013-05-31

    The direct methanol fuel cell (DMFC) is ideal if high energy-density liquid fuels are required. Liquid fuels have advantages over compressed hydrogen including higher energy density and ease of handling. Although state-of-the-art DMFCs exhibit manageable degradation rates, excessive fuel crossover diminishes system energy and power density. Although use of dilute methanol mitigates crossover, the concomitant lowering of the gross fuel energy density (GFED) demands a complex balance-of-plant (BOP) that includes higher flow rates, external exhaust recirculation, etc. An alternative approach is redesign of the fuel delivery system to accommodate concentrated methanol. NuVant Systems Inc. (NuVant) will maximize the GFED by design and assembly of a DMFC that uses near neat methanol. The approach is to tune the diffusion of highly concentrated methanol (to the anode catalytic layer) to the back-diffusion of water formed at the cathode (i.e. in situ generation of dilute methanol at the anode layer). Crossover will be minimized without compromising the GFED by innovative integration of the anode flow-field and the diffusion layer. The integrated flow-field-diffusion-layers (IFDLs) will widen the current and potential DMFC operating ranges and enable the use of cathodes optimized for hydrogen-air fuel cells.

  17. Gravity Field and Internal Structure of Mercury from MESSENGER

    Science.gov (United States)

    Smith, David E.; Zuber, Maria T.; Phillips, Roger J.; Solomon, Sean C.; Hauck, Steven A., II; Lemoine, Frank G.; Mazarico, Erwan; Neumann, Gregory A.; Peale, Stanton J.; Margot, Jean-Luc; hide

    2012-01-01

    Radio tracking of the MESSENGER spacecraft has provided a model of Mercury's gravity field. In the northern hemisphere, several large gravity anomalies, including candidate mass concentrations (mascons), exceed 100 milli-Galileos (mgal). Mercury's northern hemisphere crust is thicker at low latitudes and thinner in the polar region and shows evidence for thinning beneath some impact basins. The low-degree gravity field, combined with planetary spin parameters, yields the moment of inertia C/M(R(exp 2) = 0.353 +/- 0.017, where M and R are Mercury's mass and radius, and a ratio of the moment of inertia of Mercury's solid outer shell to that of the planet of C(sub m)/C = 0.452 +/- 0.035. A model for Mercury s radial density distribution consistent with these results includes a solid silicate crust and mantle overlying a solid iron-sulfide layer and an iron-rich liquid outer core and perhaps a solid inner core.

  18. Brain structure–function associations in multi-generational families genetically enriched for bipolar disorder

    Science.gov (United States)

    Schür, Remmelt; Sjouwerman, Rachel; Service, Susan K.; Araya, Carmen; Araya, Xinia; Bejarano, Julio; Knowles, Emma; Gomez-Makhinson, Juliana; Lopez, Maria C.; Aldana, Ileana; Teshiba, Terri M.; Abaryan, Zvart; Al-Sharif, Noor B.; Navarro, Linda; Tishler, Todd A.; Altshuler, Lori; Bartzokis, George; Escobar, Javier I.; Glahn, David C.; Thompson, Paul M.; Lopez-Jaramillo, Carlos; Macaya, Gabriel; Molina, Julio; Reus, Victor I.; Sabatti, Chiara; Cantor, Rita M.; Freimer, Nelson B.; Bearden, Carrie E.

    2015-01-01

    Recent theories regarding the pathophysiology of bipolar disorder suggest contributions of both neurodevelopmental and neurodegenerative processes. While structural neuroimaging studies indicate disease-associated neuroanatomical alterations, the behavioural correlates of these alterations have not been well characterized. Here, we investigated multi-generational families genetically enriched for bipolar disorder to: (i) characterize neurobehavioural correlates of neuroanatomical measures implicated in the pathophysiology of bipolar disorder; (ii) identify brain–behaviour associations that differ between diagnostic groups; (iii) identify neurocognitive traits that show evidence of accelerated ageing specifically in subjects with bipolar disorder; and (iv) identify brain–behaviour correlations that differ across the age span. Structural neuroimages and multi-dimensional assessments of temperament and neurocognition were acquired from 527 (153 bipolar disorder and 374 non-bipolar disorder) adults aged 18–87 years in 26 families with heavy genetic loading for bipolar disorder. We used linear regression models to identify significant brain–behaviour associations and test whether brain–behaviour relationships differed: (i) between diagnostic groups; and (ii) as a function of age. We found that total cortical and ventricular volume had the greatest number of significant behavioural associations, and included correlations with measures from multiple cognitive domains, particularly declarative and working memory and executive function. Cortical thickness measures, in contrast, showed more specific associations with declarative memory, letter fluency and processing speed tasks. While the majority of brain–behaviour relationships were similar across diagnostic groups, increased cortical thickness in ventrolateral prefrontal and parietal cortical regions was associated with better declarative memory only in bipolar disorder subjects, and not in non-bipolar

  19. Potential Magnetic Field around a Helical Flux-rope Current Structure in the Solar Corona

    OpenAIRE

    Petrie, G. J. D.

    2007-01-01

    We consider the potential magnetic field associated with a helical electric line current flow, idealizing the near-potential coronal field within which a highly localized twisted current structure is embedded. It is found that this field has a significant axial component off the helical magnetic axis where there is no current flow, such that the flux winds around the axis. The helical line current field, in including the effects of flux rope writhe, is therefore more topologically complex tha...

  20. Oxcarbazepine in the maintenance treatment of bipolar disorder.

    Science.gov (United States)

    Vasudev, A; Macritchie, K; Watson, S; Geddes, J R; Young, A H

    2008-01-23

    Some studies have suggested that oxcarbazepine has a role in preventing episode recurrence in bipolar affective disorder. This review attempted to investigate the existing evidence from randomised controlled trials for its use in the maintenance treatment of this illness. To review the efficacy of oxcarbazepine, relative to placebo and other agents, in the prevention of affective episodes of bipolar affective disorder. The efficacy of oxcarbazepine was considered in terms of episode recurrence, general and social functioning. Adverse effects, overall acceptability to participants and mortality were also considered. CCDANCTR-Studies and CCDANCTR-References were searched on 7/11/2007. Medline, CENTRAL, EMBASE and PsycINFO were searched in March 2007. Specialist journals and conference proceedings were handsearched. Reference lists of relevant papers and major textbooks of affective disorder were checked. Authors, experts in the field and pharmaceutical companies were contacted requesting information on published or unpublished trials. Randomised controlled trials comparing oxcarbazepine with placebo or alternative agents, where the stated intent of intervention was the maintenance treatment of bipolar affective disorder were sought. Participants with bipolar disorder, male and female, of all ages, were included. Data were extracted from the original reports individually by two review authors. The methodological quality of included studies was assessed individually by two review authors. The main outcomes were the efficacy of oxcarbazepine maintenance treatment in preventing or attenuating further episodes of bipolar affective disorder (including its efficacy in rapid cycling disorder), the acceptability of oxcarbazepine treatment to participants, the prevalence of side-effects, and mortality, if any, on oxcarbazepine treatment. Where appropriate, data concerning outcome measures and adverse effects were to be extracted from the studies and analysed using Review

  1. An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis.

    Science.gov (United States)

    Oedegaard, Christine H; Berk, Lesley; Berk, Michael; Youngstrom, Eric A; Dilsaver, Steven C; Belmaker, Robert H; Oedegaard, Ketil J; Fasmer, Ole B; Engebretsen, Ingunn M

    2016-11-01

    Clinical management of bipolar disorder patients might be affected by culture and is further dependent on the context of healthcare delivery. There is a need to understand how healthcare best can be delivered in various systems and cultures. The objective of this qualitative study was to gain knowledge about culture-specific values, beliefs and practices in the medical care provided to patients with bipolar disorders from a provider perspective in various areas of the world. The International Society for Bipolar Disorders (ISBD) network provided the framework for this qualitative study. An electronic interview with open-ended questions was administered to 19 international experts on bipolar spectrum disorder representing the International Society for Bipolar Disorders chapter network in 16 countries and six continents. In addition, there were two in-depth interviews with bipolar spectrum disorder experts done prior to the survey. The data were analysed using content analysis, and the information was structured using the software NVivo by QSR International Pty Ltd. All participants described sociocultural factors as important in healthcare delivery to bipolar patients in their part of the world, both in accessing healthcare and in providing culturally appropriate care. Factors that affected the provider's ability to supply good clinical management of patients were access to treatment options and long-term follow-up, as well as general strategies to combat stigma. In some societies, the patients' use of alternative treatments, gender issues and religion were also important factors. Understanding the impact of such culturally specific factors was overall regarded as essential for proper treatment interventions. Sociocultural factors clearly affect the nature and quality of medical services delivered to bipolar patients. Financial, social and cultural factors affect patients' health-seeking behaviour, and this highlights the need for knowledge about such factors in

  2. Prevalence and correlates of bipolar disorders in patients with eating disorders.

    Science.gov (United States)

    Tseng, Mei-Chih Meg; Chang, Chin-Hao; Chen, Kuan-Yu; Liao, Shih-Cheng; Chen, Hsi-Chung

    2016-01-15

    To investigate the prevalence and correlates of bipolar disorders in patients with eating disorders (EDs), and to examine differences in effects between major depressive disorder and bipolar disorder on these patients. Sequential attendees were invited to participate in a two-phase survey for EDs at the general psychiatric outpatient clinics. Patients diagnosed with EDs (n=288) and controls of comparable age, sex, and educational level (n=81) were invited to receive structured interviews for psychiatric co-morbidities, suicide risks, and functional level. All participants also completed several self-administered questionnaires assessing general and eating-related pathology and impulsivity. Characteristics were compared between the control, ED-only, ED with major depressive disorder, and ED with bipolar disorder groups. Patients with all ED subtypes had significantly higher rates of major depressive disorder (range, 41.3-66.7%) and bipolar disorder (range, 16.7-49.3%) than controls did. Compared to patients with only EDs, patients with comorbid bipolar disorder and those with comorbid major depressive disorder had significantly increased suicidality and functional impairments. Moreover, the group with comorbid bipolar disorder had increased risks of weight dysregulation, more impulsive behaviors, and higher rates of psychiatric comorbidities. Participants were selected in a tertiary center of a non-Western country and the sample size of individuals with bipolar disorder in some ED subtypes was small. Bipolar disorders were common in patients with EDs. Careful differentiation between bipolar disorder and major depressive disorder in patients with EDs may help predict associated psychopathology and provide accurate treatment. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. Resilience concepts in psychiatry demonstrated with bipolar disorder.

    Science.gov (United States)

    Angeler, David G; Allen, Craig R; Persson, Maj-Liz

    2018-02-09

    The term resilience describes stress-response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanistic assumptions. Engineering resilience (rebound) is used for describing the ability of subjects to recover from adverse conditions (disturbances), and is the rate of recovery. In contrast, the ecological resilience definition considers a systemic change: when complex systems (including humans) respond to disturbances by reorganizing into a new regime (stable state) where structural and functional aspects have fundamentally changed relative to the prior regime. In this context, resilience is an emergent property of complex systems. We argue that both resilience definitions and uses are appropriate in psychology and psychiatry, but although the differences are subtle, the implications and uses are profoundly different. We borrow from the field of ecology to discuss resilience concepts in the mental health sciences. In psychology and psychiatry, the prevailing view of resilience is adaptation to, coping with, and recovery (engineering resilience) from adverse social and environmental conditions. Ecological resilience may be useful for describing vulnerability, onset, and the irreversibility patterns of mental disorders. We discuss this in the context of bipolar disorder. Rebound, adaptation, and coping are processes that are subsumed within the broader systemic organization of humans, from which ecological resilience emanates. Discerning resilience concepts in psychology and psychiatry has potential for a mechanistically appropriate contextualization of mental disorders at large. This might contribute to a refinement of theory and contextualize clinical practice within the broader systemic functioning of mental illnesses.

  4. Wide bandgap collector III-V double heterojunction bipolar transistors

    International Nuclear Information System (INIS)

    Flitcroft, R.M.

    2000-10-01

    This thesis is devoted to the study and development of Heterojunction Bipolar Transistors (HBTs) designed for high voltage operation. The work concentrates on the use of wide bandgap III-V semiconductor materials as the collector material and their associated properties influencing breakdown, such as impact ionisation coefficients. The work deals with issues related to incorporating a wide bandgap collector into double heterojunction structures such as conduction band discontinuities at the base-collector junction and results are presented which detail, a number of methods designed to eliminate the effects of such discontinuities. In particular the use of AlGaAs as the base material has been successful in eliminating the conduction band spike at this interface. A method of electrically injecting electrons into the collector has been employed to investigate impact ionisation in GaAs, GaInP and AlInP which has used the intrinsic gain of the devices to extract impact ionisation coefficients over a range of electric fields beyond the scope of conventional optical injection techniques. This data has enabled the study of ''dead space'' effects in HBT collectors and have been used to develop an analytical model of impact ionisation which has been incorporated into an existing Ebers-Moll HBT simulator. This simulator has been shown to accurately reproduce current-voltage characteristics in both the devices used in this work and for external clients. (author)

  5. Spin structure factors of Heisenberg spin chain in the presence of anisotropy and magnetic field

    International Nuclear Information System (INIS)

    Rezania, H.

    2017-01-01

    We have theoretically studied the spin structure factors of spin chain in the presence of longitudinal field and transverse anisotropy. The possible effects of easy axis magnetization are investigated in terms of anisotropy in the Heisenberg interactions. This anisotropy is considered for exchange coupling constants perpendicular to magnetic field direction. The original spin model hamiltonian is mapped to a bosonic model via a hard core bosonic transformation where an infinite hard core repulsion is imposed to constrain one boson occupation per site. Using Green's function approach, the energy spectrum of quasiparticle excitation has been obtained. The spectrum of the bosonic gas has been implemented in order to obtain two particle propagator which corresponds to spin structure factor of original Heisenberg chain model Hamiltonian. The results show the position of peak in the longitudinal structure factor at fixed value for anisotropy moves to higher frequency with magnetic field. Also the intensity of dynamical structure factor decreases with magnetic field. A small dependence of longitudinal dynamical spin structure factor on the anisotropy is observed for fixed value of magnetic field. Our results show longitudinal static structure factor is found to be monotonically increasing with magnetic field due to increase of spins aligning along magnetic field. Furthermore the dispersion behaviors of static longitudinal and transverse structure factors for different magnetic fields and anisotropy parameters are addressed. - Highlights: • Theoretical calculation of spin structure factors of Heisenberg chain. • The investigation of the effect of anisotropy spin structure factors of Heisenberg chain. • The investigation of the effect of magnetic field on spin structure factors of Heisenberg chain.

  6. Spin structure factors of Heisenberg spin chain in the presence of anisotropy and magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Rezania, H., E-mail: rezania.hamed@gmail.com

    2017-02-01

    We have theoretically studied the spin structure factors of spin chain in the presence of longitudinal field and transverse anisotropy. The possible effects of easy axis magnetization are investigated in terms of anisotropy in the Heisenberg interactions. This anisotropy is considered for exchange coupling constants perpendicular to magnetic field direction. The original spin model hamiltonian is mapped to a bosonic model via a hard core bosonic transformation where an infinite hard core repulsion is imposed to constrain one boson occupation per site. Using Green's function approach, the energy spectrum of quasiparticle excitation has been obtained. The spectrum of the bosonic gas has been implemented in order to obtain two particle propagator which corresponds to spin structure factor of original Heisenberg chain model Hamiltonian. The results show the position of peak in the longitudinal structure factor at fixed value for anisotropy moves to higher frequency with magnetic field. Also the intensity of dynamical structure factor decreases with magnetic field. A small dependence of longitudinal dynamical spin structure factor on the anisotropy is observed for fixed value of magnetic field. Our results show longitudinal static structure factor is found to be monotonically increasing with magnetic field due to increase of spins aligning along magnetic field. Furthermore the dispersion behaviors of static longitudinal and transverse structure factors for different magnetic fields and anisotropy parameters are addressed. - Highlights: • Theoretical calculation of spin structure factors of Heisenberg chain. • The investigation of the effect of anisotropy spin structure factors of Heisenberg chain. • The investigation of the effect of magnetic field on spin structure factors of Heisenberg chain.

  7. Root Structures of Infinite Gauge Groups and Supersymmetric Field Theories

    International Nuclear Information System (INIS)

    Catto, Sultan; Gürcan, Yasemin; Khalfan, Amish; Kurt, Levent

    2013-01-01

    We show the relationship between critical dimensions of supersymmetric fundamental theories and dimensions of certain Jordan algebras. In our approach position vectors in spacetime or in superspace are endowed with algebraic properties that are present only in those critical dimensions. A uniform construction of super Poincaré groups in these dimensions will be shown. Some applications of these algebraic methods to hidden symmetries present in the covariant and interacting string Lagrangians and to superparticle will be discussed. Algebraic methods we develop will be shown to generate the root structure of some infinite groups that play the role of gauge groups in a second quantized theory of strings

  8. Structure of superheavy elements with Meson field theory and beyond

    International Nuclear Information System (INIS)

    Walter Greiner

    2005-01-01

    The extension of the periodic system into various new areas is investigated. Experiments for the synthesis of superheavy elements and the predictions of magic numbers with modern meson field theories are reviewed. Furtheron, different channels of nuclear decay are discussed including cluster radioactivity, cold fission and cold multifragmentation. A perspective for future research is given. We also study the possibility of producing a new kind of nuclear system that in addition to ordinary nucleons contains a few antibaryons. The properties of such systems are described within the relativistic mean-field model by employing G-parity transformed interactions for antibaryons. Calculations are first done for infinite systems and then for finite nuclei from 4 He to 208 Pb. It is demonstrated that the presence of a real antibaryon leads to a strong rearrangement of a target nucleus, resulting in a significant increase of its binding energy and local compression. Noticeable effects remain even after the antibaryon coupling constants are reduced by a factor of 3-4 compared to G-parity motivated values. We have performed detailed calculations of the antibaryon annihilation rates in the nuclear environment by applying a kinetic approach. It is shown that owing to significant reduction of the reaction Q values, the in-medium annihilation rates should be strongly suppressed, leading to relatively long-lived antibaryon- nucleus systems. Multinucleon annihilation channels are analyzed too. We have also estimated formation probabilities of bound antibaryon-nucleus systems in antiproton- nucleus reactions and have found that their observation will be feasible at the future GSI antiproton facility. Several observable signatures are proposed. The possibility of producing cold multi-quark-antiquark clusters is discussed. This opens the possibility for cold compression of nuclear matter - in contrast to the creation of hot and dense nuclear matter in nuclear shock waves created in

  9. Unsplit bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A [Pleasanton, CA

    2011-05-24

    A bipolar pulse forming transmission line module and system for linear induction accelerators having first, second, third, and fourth planar conductors which form a sequentially arranged interleaved stack having opposing first and second ends, with dielectric layers between the conductors. The first and second planar conductors are connected to each other at the first end, and the first and fourth planar conductors are connected to each other at the second end via a shorting plate. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short at the first end a high voltage from the third planar conductor to the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  10. Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression from Bipolar Disorder Not Otherwise Specified

    Science.gov (United States)

    Axelson, David A.; Birmaher, Boris; Strober, Michael A.; Goldstein, Benjamin I.; Ha, Wonho; Gill, Mary Kay; Goldstein, Tina R.; Yen, Shirley; Hower, Heather; Hunt, Jeffrey I.; Liao, Fangzi; Iyengar, Satish; Dickstein, Daniel; Kim, Eunice; Ryan, Neal D.; Frankel, Erica; Keller, Martin B.

    2011-01-01

    Objective: To determine the rate of diagnostic conversion from an operationalized diagnosis of bipolar disorder not otherwise specified (BP-NOS) to bipolar I disorder (BP-I) or bipolar II disorder (BP-II) in youth over prospective follow-up and to identify factors associated with conversion. Method: Subjects were 140 children and adolescents…

  11. A new support structure for high field magnets

    CERN Document Server

    Hafalia, R R; Caspi, S; Dietderich, D R; Gourlay, S A; Hannaford, R; Lietzke, A F; Liggins, N; McInturff, A D; Sabbi, G L; Scanlan, R M; O'Neill, J; Swanson, J H

    2002-01-01

    Pre-stress of superconducting magnets can be applied directly through the magnet yoke structure. We have replaced the collar functionality in our 14 Tesla R&D Nb//3Sn dipole magnets with an assembly procedure based on an aluminum shell and bladders. Bladders, placed between the coil pack and surrounding yoke inside the shell, are pressurized up to 10 ksi left bracket 70 MPa right bracket to create an interference gap. Keys placed into the interference gap replace the bladder functionality. Following the assembly, the bladders are deflated and removed. Strain gauges mounted directly on the shell are used to monitor the stress of the entire magnet structure, thereby providing a high degree of pre-stress control without the need for high tolerances. During assembly, a force of 8.2 multiplied by 10**5 lbs /ft left bracket 12 MN/m right bracket is generated by the bladders and the stress in the 1.57 double prime left bracket 40 mm right bracket aluminum shell reaches 20.3 ksi left bracket 140 MPa right bracket...

  12. Field-modulation spectroscopy of pentacene thin films using field-effect devices: Reconsideration of the excitonic structure

    Science.gov (United States)

    Haas, Simon; Matsui, Hiroyuki; Hasegawa, Tatsuo

    2010-10-01

    We report pure electric-field effects on the excitonic absorbance of pentacene thin films as measured by unipolar field-effect devices that allowed us to separate the charge accumulation effects. The field-modulated spectra between 1.8 and 2.6 eV can be well fitted with the first derivative curve of Frenkel exciton absorption and its vibronic progression, and at higher energy a field-induced feature appears at around 2.95 eV. The results are in sharp contrast to the electroabsorption spectra reported by Sebastian in previous studies [Chem. Phys. 61, 125 (1981)10.1016/0301-0104(81)85055-0], and leads us to reconsider the excitonic structure including the location of charge-transfer excitons. Nonlinear π -electronic response is discussed based on second-order electro-optic (Kerr) spectra.

  13. Structure and magnetic field of periodic permanent magnetic focusing system with open magnetic rings

    International Nuclear Information System (INIS)

    Peng Long; Li Lezhong; Yang Dingyu; Zhu Xinghua; Li Yuanxun

    2011-01-01

    The magnetic field along the central axis for an axially magnetized permanent magnetic ring was investigated by analytical and finite element methods. For open magnetic rings, both calculated and measured results show that the existence of the radial magnetic field creates a remarkable cosine distribution field along the central axis. A new structure of periodic permanent magnet focusing system with open magnetic rings is proposed. The structure provides a satisfactory magnetic field with a stable peak value of 120 mT for a traveling wave tube system. - Research highlights: → For open magnetic rings, both calculated and measured results show that the existence of the radial magnetic field creates a remarkable cosine distribution field along the central axis. → A new structure of periodic permanent magnet (PPM) focusing system with open magnetic rings is proposed. → The new PPM focusing system with open magnetic rings meets the requirements for TWT system.

  14. Bipolar (spectrum) disorder and mood stabilization: standing at the crossroads?

    OpenAIRE

    De Fruyt, Jurgen; Demyttenaere, Koen

    2007-01-01

    Diagnosis and treatment of bipolar disorder has long been a neglected discipline. Recent years have shown an upsurge in bipolar research. When compared to major depressive disorder, bipolar research still remains limited and more expert based than evidence based. In bipolar diagnosis the focus is shifting from classic mania to bipolar depression and hypomania. There is a search for bipolar signatures in symptoms and course of major depressive episodes. The criteria for hypomania are softened,...

  15. Heliospheric magnetic field polarity inversions driven by radial velocity field structures

    Czech Academy of Sciences Publication Activity Database

    Landi, S.; Hellinger, Petr; Velli, M.

    2006-01-01

    Roč. 33, č. 14 (2006), L14101/1-L14101/5 ISSN 0094-8276 Grant - others:European Commission(XE) HRPN-CT-2001-00310 Institutional research plan: CEZ:AV0Z30420517 Keywords : solar wind * magnetic field polarity inversions * microstreams * turbulence Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.602, year: 2006

  16. [Bipolar disorders in DSM-5].

    Science.gov (United States)

    Severus, E; Bauer, M

    2014-05-01

    In spring 2013 the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) edited by the American Psychiatric Association was published. The DSM-5 has also brought some important changes regarding bipolar disorders. The goal of this manuscript is to review the novelties in DSM-5 and to evaluate the implications of these changes. The diagnostic criteria as well as the additional remarks provided in the running text of DSM-5 were carefully appraised. For the first time diagnostic criteria are provided for disorders which up to now have been considered as subthreshold bipolar disorders. Furthermore, mixed episodes were eliminated and instead a mixed specifier was introduced. An increase in goal-directed activity/energy is now one of the obligatory symptoms for a (hypo)manic episode. Diagnostic guidance is provided as to when a (hypo)manic episode that has developed during treatment with an antidepressant has to be judged to be causally related to antidepressants and when this episode has only occurred coincidentally with antidepressant use. While some of the novelties are clearly useful, e.g. addition of increased goal-directed activity/energy as obligatory symptom for (hypo)manic episodes, this remains to be demonstrated for others, such as the definition of various subthreshold bipolar disorders.

  17. Polar cap electric field structures with a northward interplanetary magnetic field

    International Nuclear Information System (INIS)

    Burke, W.J.; Kelley, M.C.; Sagalyn, R.C.; Smiddy, M.; Lai, S.T.

    1979-01-01

    Polar cap electric fields patterns are presented from times when the S3-2 Satellite was near the dawn-dusk meridian and IMF data were available. With B/sub z/> or =0.7γ, two characteristic types of electric field patterns were measured in the polar cap. In the sunlit polar cap the convection pattern usually consisted of four cells. Two of the cells were confined to the polar cap with sunward convection in the central portion of the cap. The other pair of cells were marked by anti-sunward flow along the flanks of the polar cap and by sunward flow in the auroral oval. These observations are interpreted in terms of a model for magnetic merging at the poleward wall of the dayside polar cusp. The sunward flow in the auroral zone is not predicted by the magnetic model and may be due to a viscous interaction between the solar wind and and magnetosphere. The second type, which was observed in some of the summer hemisphere passes and all of the winter ones, was characterized by an electric field pattern which was very turbulent, and may be related to inhomogeneous merging

  18. Virginia Woolf, neuroprogression, and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Manuela V. Boeira

    2016-01-01

    Full Text Available Family history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also known that patients with early childhood trauma present earlier onset of bipolar disorder, increased number of manic episodes, and more suicide attempts. We have recently reported that childhood trauma partly mediates the effect of family history on bipolar disorder diagnosis. In light of these findings from the scientific literature, we reviewed the work of British writer Virginia Woolf, who allegedly suffered from bipolar disorder. Her disorder was strongly related to her family background. Moreover, Virginia Woolf was sexually molested by her half siblings for nine years. Her bipolar disorder symptoms presented a pernicious course, associated with hospitalizations, suicidal behavioral, and functional impairment. The concept of neuroprogression has been used to explain the clinical deterioration that takes places in a subgroup of bipolar disorder patients. The examination of Virgina Woolf’s biography and art can provide clinicians with important insights about the course of bipolar disorder.

  19. Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity

    Directory of Open Access Journals (Sweden)

    Necla Keskin

    2014-08-01

    Full Text Available The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients. Some genetic variants, neurotransmitters especially serotonergic systems and second-messenger systems are thought to be responsible for its etiology. Bipolar disorder alters the clinical aspects of obsessive compulsive disorder and is associated with poorer outcome. The determination of comorbidity between bipolar disorder and obsessive compulsive disorder is quite important for appropriate clinical management and treatment. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(4.000: 429-437

  20. [Lithium and anticonvulsants in bipolar depression].

    Science.gov (United States)

    Samalin, L; Nourry, A; Llorca, P-M

    2011-12-01

    For decades, lithium and anticonvulsants have been widely used in the treatment of bipolar disorder. Their efficacy in the treatment of mania is recognized. These drugs have been initially evaluated in old and methodologically heterogeneous studies. Their efficacy in bipolar depression has not always been confirmed in more recent and methodologically more reliable studies. Thus, lithium's efficacy as monotherapy was challenged by the study of Young (2008) that showed a lack of efficacy compared with placebo in the treatment of bipolar depression. In two recent meta-analyses, valproate has shown a modest efficacy in the treatment of bipolar depression. As for lithium, valproate appeared to have a larger antimanic effect for acute phase and prophylaxis of bipolar disorder. In contrast, lamotrigine is more effective on the depressive pole of bipolar disorder with better evidence for the prevention of depressive recurrences. The guidelines include these recent studies and recommend lamotrigine as a first-line treatment of bipolar depression and for maintenance treatment. Because of more discordant data concerning lithium and valproate, these two drugs are placed either as first or as second line treatment of bipolar depression. The different safety/efficacy ratios of mood stabilizers underlie the complementarity and the importance of combination between them, or with some second-generation antipsychotics, in the treatment of patients with bipolar disorder. Copyright © 2011 L’Encéphale. Published by Elsevier Masson SAS.. All rights reserved.

  1. Late Onset Bipolar Disorder: Case Report

    Directory of Open Access Journals (Sweden)

    Filipa Araújo

    2016-07-01

    Full Text Available Background: Bipolar disorder affects approximately 1% of the population, with diagnosis often being made during late adolescence and early adulthood, and only rarely (0.1% in the elderly. Late onset bipolar disorder in the elderly has a impact on the nature and course of bipolar disorder. Aims: The authors report a case of bipolar disorder emerging in late life  (76years old with no cleary identified organic cause. Conclusion: This case highlights the importance of a broad differential diagnosis and pharmacologic management when approaching new-onset manic/depressive symptoms among geriatric patients.

  2. Dysfunctional gaze processing in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Cristina Berchio

    2017-01-01

    The present study provides neurophysiological evidence for abnormal gaze processing in BP and suggests dysfunctional processing of direct eye contact as a prominent characteristic of bipolar disorder.

  3. Electric-field effects on electronic tunneling transport in magnetic barrier structures

    International Nuclear Information System (INIS)

    Guo Yong; Wang Hao; Gu Binglin; Kawazoe, Yoshiyuki

    2000-01-01

    Electronic transport properties in magnetic barrier structures under the influence of an electric field have been investigated. The results indicate that the characteristics of transmission resonance are determined not only by the structure and the incident wave vector but also strongly by the electric field. It is shown that the transmission coefficient at resonance in the low-energy range is suppressed by applying the electric field for electron tunneling through the magnetic barrier structure, arranged with identical magnetic barriers and wells. It is also shown that the transmission resonance is first enhanced up to optimal resonance, and then suppressed with further increased electric field for electron tunneling through the magnetic barrier structure, arranged with unidentical building blocks. Strong suppression of the current density is also found in the magnetic barrier structure, arranged with two different building blocks

  4. The origin of fine structure in near-field scanning optical lithography of an electroactive polymer

    International Nuclear Information System (INIS)

    Cotton, Daniel V; Belcher, Warwick J; Dastoor, Paul C; Fell, Christopher J

    2008-01-01

    Near-field scanning optical lithography (NSOL) has been used to produce arbitrary structures of the electroactive polymer polyphenylenevinylene at sizes comparable to optical wavelengths, which are of interest for integrated optical devices. The structures are characterized using AFM and SEM and exhibit interesting fine structure. The characteristic size and shape of the lithographic features and their associated fine structure have been examined in the context of the electric field distribution at the near-field scanning optical microscope tip. In particular, the Bethe-Bouwkamp model for electric field distribution at an aperture has been used in combination with a recently developed model for precursor solubility dependence on UV energy dose to predict the characteristics of lithographic features produced by NSOL. The fine structure in the lithographic features is also investigated and explained. Suggestions for the further improvement of the technique are made.

  5. Peripheral inflammation during abnormal mood states in bipolar I disorder.

    Science.gov (United States)

    Fiedorowicz, Jess G; Prossin, Alan R; Johnson, Casey P; Christensen, Gary E; Magnotta, Vincent A; Wemmie, John A

    2015-11-15

    Bipolar disorder carries a substantive morbidity and mortality burden, particularly related to cardiovascular disease. Abnormalities in peripheral inflammatory markers, which have been commonly reported in case-control studies, potentially link these co-morbidities. However, it is not clear whether inflammatory markers change episodically in response to mood states or are indicative of chronic pro-inflammatory activity, regardless of mood, in bipolar disorder. Investigations focused on comparing concentrations of specific inflammatory cytokines associated with immune activation status (primary outcome=tumor necrosis factor alpha (TNF-α)) in 37 participants with bipolar disorder across 3 mood states (mania N=15, depression N=9, normal mood N=13) and 29 controls without a psychiatric disorder (total N=66). Cytokine levels were also compared to T1ρ, a potential neuroimaging marker for inflammation, in select brain regions in a subsample (N=39). Participants with bipolar disorder and healthy controls did not differ significantly in inflammatory cytokine concentrations. However, compared to cases with normal mood, cases with abnormal mood states (mania and depression) had significantly elevated levels of TNF-α, its soluble receptors (sTNFR1/sTNFR2), other macrophage-derived cytokines (interleukin 1β (IL-1β), IL-6, IL-10, and IL-18) in addition to IL-4, interferon-γ, monocyte chemotactic protein-1, fibroblast growth factor β, and vascular endothelial growth factor. Cytokine levels were not correlated with signals from T1ρ imaging in selected structures (amygdalae, hippocampi, hypothalamus, anterior cingulate gyrus, and middle frontal gyrus). Participants were not followed prospectively across mood states. Activation of inflammatory markers was found in abnormal mood states of bipolar disorder. Longitudinal study of individuals with mood disorders is needed to confirm these findings and to elucidate the time course of any such changes. Copyright © 2015 Elsevier B

  6. Single-field consistency relations of large scale structure

    International Nuclear Information System (INIS)

    Creminelli, Paolo; Noreña, Jorge; Simonović, Marko; Vernizzi, Filippo

    2013-01-01

    We derive consistency relations for the late universe (CDM and ΛCDM): relations between an n-point function of the density contrast δ and an (n+1)-point function in the limit in which one of the (n+1) momenta becomes much smaller than the others. These are based on the observation that a long mode, in single-field models of inflation, reduces to a diffeomorphism since its freezing during inflation all the way until the late universe, even when the long mode is inside the horizon (but out of the sound horizon). These results are derived in Newtonian gauge, at first and second order in the small momentum q of the long mode and they are valid non-perturbatively in the short-scale δ. In the non-relativistic limit our results match with [1]. These relations are a consequence of diffeomorphism invariance; they are not satisfied in the presence of extra degrees of freedom during inflation or violation of the Equivalence Principle (extra forces) in the late universe

  7. Fibre bundles associated with fields of geometric objects and a structure tensor

    International Nuclear Information System (INIS)

    Konderak, J.

    1987-08-01

    A construction of a k th structure tensor of a field of geometric objects is presented here (k is a non-negative integer). For a given field σ we construct a vector bundle H k,2 (σ). The k th structure tensor is defined as a section of H k,2 (σ) generated by the torsion of σ. It is then shown that vanishing of the k th structure tensor is a necessary and sufficient condition for the field to be (k + 1)-flat. (author). 16 refs

  8. Temperature- and field-induced structural transitions in magnetic colloidal clusters

    Science.gov (United States)

    Hernández-Rojas, J.; Calvo, F.

    2018-02-01

    Magnetic colloidal clusters can form chain, ring, and more compact structures depending on their size. In the present investigation we examine the combined effects of temperature and external magnetic field on these configurations by means of extensive Monte Carlo simulations and a dedicated analysis based on inherent structures. Various thermodynamical, geometric, and magnetic properties are calculated and altogether provide evidence for possibly multiple structural transitions at low external magnetic field. Temperature effects are found to overcome the ordering effect of the external field, the melted stated being associated with low magnetization and a greater compactness. Tentative phase diagrams are proposed for selected sizes.

  9. New insight into the parasitic bipolar amplification effect in single event transient production

    International Nuclear Information System (INIS)

    Chen Jian-Jun; Chen Shu-Ming; Liang Bin; Deng Ke-Feng

    2012-01-01

    In this paper, a new method is proposed to study the mechanism of charge collection in single event transient (SET) production in 90 nm bulk complementary metal oxide semiconductor (CMOS) technology. We find that different from the case in the pMOSFET, the parasitic bipolar amplification effect (bipolar effect) in the balanced inverter does not exist in the nMOSFET after the ion striking. The influence of the substrate process on the bipolar effect is also studied in the pMOSFET. We find that the bipolar effect can be effectively mitigated by a buried deep P + -well layer and can be removed by a buried SO 2 layer. (condensed matter: structural, mechanical, and thermal properties)

  10. The Reciprocal Relationship between Bipolar Disorder and Social Interaction: A Qualitative Investigation.

    Science.gov (United States)

    Owen, Rebecca; Gooding, Patricia; Dempsey, Robert; Jones, Steven

    2017-07-01

    Evidence suggests that social support can influence relapse rates, functioning and various clinical outcomes in people with bipolar disorder. Yet 'social support' is a poorly defined construct, and the mechanisms by which it affects illness course in bipolar disorder remain largely unknown. Key aims of this study were to ascertain which facets of social interaction affect mood management in bipolar disorder, and how symptoms of bipolar disorder can influence the level of support received. Semi-structured qualitative interviews were conducted with 20 individuals with bipolar disorder. Questions were designed to elicit: the effects of social interaction upon the management and course of bipolar disorder; and the impact of bipolar disorder upon social relationships. An inductive thematic analysis was used to analyse the data. Empathy and understanding from another person can make it easier to cope with bipolar disorder. Social interaction can also provide opportunities to challenge negative ruminative thoughts and prevent the onset of a major mood episode. The loss of social support, particularly through bereavement, creates a loss of control and can trigger mania or depression. Hypomanic symptoms can facilitate new social connections, whereas disinhibited and risky behaviour exhibited during mania can cause the breakdown of vital relationships. An in-depth clinical formulation of an individual's perceptions of how their illness affects and is affected by social interaction is crucial to understanding psychosocial factors which influence mood management. These results have clear application in interventions which aim to promote improved wellbeing and social functioning in bipolar disorder. Copyright © 2016 John Wiley & Sons, Ltd. The relationship between bipolar-related experiences and social interaction is complex and multi-faceted. Bipolar disorder can damage social relationships and create a loss of social control via extreme mood states, but it can also offer a

  11. Field-induced structures and rheology of a magnetorheological suspension confined between two walls

    International Nuclear Information System (INIS)

    Carletto, P; Bossis, G

    2003-01-01

    We have determined experimentally the parameters characterizing the structures formed in a magnetic colloidal suspension subjected to a unidirectional magnetic field and a rotating field for different cell thicknesses. In this latter case one observes the formation of a periodic structure in parallel sheets situated in the plane of rotation of the field. A theoretical model based on minimization of the energy allows one to find quantitatively the observations obtained in a unidirectional field. On the other hand, in a rotating field, the agreement is quantitative only if we take the surface energy as an adjustable parameter. We explain this fact on the basis of the existence of a substructure made of discs of particles. In a second part we show the influence of the structures on the rheological properties of the suspension by measuring the shear moduli for different kinds of structure. We find that for the same magnetic field, the shear moduli depend strongly on the structure and can be quite well predicted by a mean field theory; also the critical shear strain is determined and is in agreement with the model. Finally we show that, in a regime with a unidirectional oscillating field without shear flow, a new phenomenon appears if the confining walls are not parallel. In this case we observe the formation of anisotropic aggregates which undergo a collective chaotic rotation around the axis of the aggregates

  12. Bipolar mixed features - Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study.

    Science.gov (United States)

    Tohen, Mauricio; Gold, Alexandra K; Sylvia, Louisa G; Montana, Rebecca E; McElroy, Susan L; Thase, Michael E; Rabideau, Dustin J; Nierenberg, Andrew A; Reilly-Harrington, Noreen A; Friedman, Edward S; Shelton, Richard C; Bowden, Charles L; Singh, Vivek; Deckersbach, Thilo; Ketter, Terence A; Calabrese, Joseph R; Bobo, William V; McInnis, Melvin G

    2017-08-01

    DSM-5 changed the criteria from DSM-IV for mixed features in mood disorder episodes to include non-overlapping symptoms of depression and hypomania/mania. It is unknown if, by changing these criteria, the same group would qualify for mixed features. We assessed how those meeting DSM-5 criteria for mixed features compare to those meeting DSM-IV criteria. We analyzed data from 482 adult bipolar patients in Bipolar CHOICE, a randomized comparative effectiveness trial. Bipolar diagnoses were confirmed through the MINI International Neuropsychiatric Interview (MINI). Presence and severity of mood symptoms were collected with the Bipolar Inventory of Symptoms Scale (BISS) and linked to DSM-5 and DSM-IV mixed features criteria. Baseline demographics and clinical variables were compared between mood episode groups using ANOVA for continuous variables and chi-square tests for categorical variables. At baseline, the frequency of DSM-IV mixed episodes diagnoses obtained with the MINI was 17% and with the BISS was 20%. Using DSM-5 criteria, 9% of participants met criteria for hypomania/mania with mixed features and 12% met criteria for a depressive episode with mixed features. Symptom severity was also associated with increased mixed features with a high rate of mixed features in patients with mania/hypomania (63.8%) relative to those with depression (8.0%). Data on mixed features were collected at baseline only and thus do not reflect potential patterns in mixed features within this sample across the study duration. The DSM-5 narrower, non-overlapping definition of mixed episodes resulted in fewer patients who met mixed criteria compared to DSM-IV. Copyright © 2017. Published by Elsevier B.V.

  13. Gravity Field and Interior Structure of Saturn from Cassini Observations

    Science.gov (United States)

    Anderson, J. D.; Schubert, G.

    2007-05-01

    We discuss the sources for a determination of Saturn's external gravitational potential, beginning with a Pioneer 11 flyby in September 1979, two Voyager flybys in November 1980 for Voyager 1 and August 1981 for Voyager 2, four useful close approaches by the Cassini orbiter in May and June 2005, and culminating in an extraordinary close approach for Radio Science in September 2006. Results from the 2006 data are not yet available, but even without them, Cassini offers improvements in accuracy over Pioneer and Voyager by a factor of 37 in the zonal coefficient J2, a factor of 14 in J4, and a factor of 5 in J6. These improvements are important to our understanding of the internal structure of Saturn in particular, and to solar and extrasolar giant planets in general. Basically, Saturn can be modeled as a rapidly rotating planet in hydrostatic equilibrium. Consistent with the limited data available, we express the density distribution as a polynomial of fifth degree in the normalized mean radius β = r/R over the real interval zero to one, where R is the radius of a sphere with density equal to the mean density of Saturn. Then the six coefficients of the polynomial are adjusted by nonlinear least squares until they match the measured even zonal gravity coefficients J2,J4,J6 within a fraction of a standard deviation. The gravity coefficients are computed from the density distribution by the method of level surfaces to the third order in the rotational smallness parameter. Two degrees of freedom are removed by applying the constraints that (1)~the derivative of the density distribution is zero at the center, and (2)~the density is zero at the surface. Further, a unique density distribution is obtained by the method of singular value decomposition truncated at rank three. Given this unique density distribution, the internal pressure can be obtained by numerical integration of the equation of hydrostatic equilibrium, expressed in terms of the single independent parameter

  14. At technique for visualizing electrostatic fields based on their topological structures

    International Nuclear Information System (INIS)

    Handa, Susumu

    2004-01-01

    In molecular science, visualization techniques based on computer graphics are now well established as a tool to interpret simulation results, since molecules are complicated in the structures and mutual interactions. As a probe to study such molecular interactions, electrostatic fields are considered to be useful. However, since they are given as 3D vector fields having complicated distributions, conventional drawing techniques are inadequate. In this article, a new approach based on topological structures in vector fields is presented to visualize the electrostatic fields of molecules. The scheme is to select regions of interest only from the topological structures of the fields. An example in applications to chemical reactions of an amino acid complex is presented to show how the scheme is used. (author)

  15. Structure of magnetic field disturbances under development of disruptive instability in the ''Tokamak-6''

    International Nuclear Information System (INIS)

    Merezhkin, V.G.

    1978-01-01

    The structure and dynamics of disturbances of a poloidal field during the development of the breakaway instability in the Tokamak-6 are investigated. The behaviour of the symmetric and dipole field component, and the peculiarities of the structure of screw disturbances in a minor and major breakaways are analyzed. It was established that the structure of screw disturbances in minor breakaways is unchangeable and that the rearrangement in major breakaways is of a discrete nature. The relationship between the symmetric and screw components of disturbances of the poloidal field at the forward front of the disturbance increase was revealed. Data on the increments, scales and structure of screw disturbances, the ratios between the symmetric and screw components of field disturbances, and also on the magnitude of energy losses in typical breakaways are given

  16. A video-image study of electrolytic flow structure in parallel electric-magnetic fields

    International Nuclear Information System (INIS)

    Gu, Z.H.; Fahidy, T.Z.

    1987-01-01

    The structure of free convective flow propagating from a vertical cathode into the electrolyte bulk has been studied via video-imaging. The enhancing effect of imposed horizontal uniform magnetic fields is manifest by vortex propagation and bifurcating flow

  17. Controlling the dynamics of a self-organized structure using a rf-field

    International Nuclear Information System (INIS)

    Talasman, S.J.; Ignat, M.

    2004-01-01

    We investigate the influence of an external rf-field upon a plasma self-organized structure. We show that depending on the intensity of this field, though it is at very low values, the dynamics of the structure can be easily controlled over a wide range of the state parameters values. This could be considered as a non-feedback method of dynamics control

  18. Crystal structure prediction of flexible molecules using parallel genetic algorithms with a standard force field.

    Science.gov (United States)

    Kim, Seonah; Orendt, Anita M; Ferraro, Marta B; Facelli, Julio C

    2009-10-01

    This article describes the application of our distributed computing framework for crystal structure prediction (CSP) the modified genetic algorithms for crystal and cluster prediction (MGAC), to predict the crystal structure of flexible molecules using the general Amber force field (GAFF) and the CHARMM program. The MGAC distributed computing framework includes a series of tightly integrated computer programs for generating the molecule's force field, sampling crystal structures using a distributed parallel genetic algorithm and local energy minimization of the structures followed by the classifying, sorting, and archiving of the most relevant structures. Our results indicate that the method can consistently find the experimentally known crystal structures of flexible molecules, but the number of missing structures and poor ranking observed in some crystals show the need for further improvement of the potential. Copyright 2009 Wiley Periodicals, Inc.

  19. A wireless sensor network design and evaluation for large structural strain field monitoring

    International Nuclear Information System (INIS)

    Qiu, Zixue; Wu, Jian; Yuan, Shenfang

    2011-01-01

    Structural strain changes under external environmental or mechanical loads are the main monitoring parameters in structural health monitoring or mechanical property tests. This paper presents a wireless sensor network designed for monitoring large structural strain field variation. First of all, a precision strain sensor node is designed for multi-channel strain gauge signal conditioning and wireless monitoring. In order to establish a synchronous strain data acquisition network, the cluster-star network synchronization method is designed in detail. To verify the functionality of the designed wireless network for strain field monitoring capability, a multi-point network evaluation system is developed for an experimental aluminum plate structure for load variation monitoring. Based on the precision wireless strain nodes, the wireless data acquisition network is deployed to synchronously gather, process and transmit strain gauge signals and monitor results under concentrated loads. This paper shows the efficiency of the wireless sensor network for large structural strain field monitoring

  20. Transient Stuttering in Catatonic Bipolar Patients

    Directory of Open Access Journals (Sweden)

    Anthony B. Joseph

    1991-01-01

    Full Text Available Two cases of transient stuttering occurring in association with catatonia and bipolar disorder are described. Affective decompensation has been associated with lateralized cerebral dysfunction, and it is hypothesized that in some bipolar catatonic patients a concomitant disorder of the lateralization of language function may lead to a variety of clinical presentations including aphasia, mutism, and stuttering.

  1. Swimming in Deep Water: Childhood Bipolar Disorder

    Science.gov (United States)

    Senokossoff, Gwyn W.; Stoddard, Kim

    2009-01-01

    The authors focused on one parent's struggles in finding a diagnosis and intervention for a child who had bipolar disorder. The authors explain the process of identification, diagnosis, and intervention of a child who had bipolar disorder. In addition to the personal story, the authors provide information on the disorder and outline strategies…

  2. Bipolar Disorder and Cognitive Therapy: A Commentary

    Science.gov (United States)

    Riskind, John H.

    2005-01-01

    This article comments on the three articles (Leahy, 2005; Newman, 2005; and Reilly-Harrington & Knauz, 2005) that deal with the applications of cognitive therapy to treatment of bipolar disorder. They focus on the uses of cognitive therapy in treating three important facets of the special problems of bipolar patients: rapid cycling, severe…

  3. Perceived parental rearing of bipolar offspring

    NARCIS (Netherlands)

    Reichart, C. G.; van der Ende, J.; Hillegers, M. H. J.; Wals, M.; Bongers, I. L.; Nolen, W. A.; Ormel, J.; Verhulst, F. C.

    Objective: To explore the impact of growing up with a parent with a bipolar disorder. First, we compared parental rearing behavior perceived by young adult offspring of bipolar parents with parental rearing behavior perceived by same aged young adults from the general population. Secondly, we

  4. Cognitive behavioral therapy for bipolar disorders

    OpenAIRE

    Lotufo Neto, Francisco

    2004-01-01

    Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  5. Density functional theory for field emission from carbon nano-structures

    Energy Technology Data Exchange (ETDEWEB)

    Li, Zhibing, E-mail: stslzb@mail.sysu.edu.cn

    2015-12-15

    Electron field emission is understood as a quantum mechanical many-body problem in which an electronic quasi-particle of the emitter is converted into an electron in vacuum. Fundamental concepts of field emission, such as the field enhancement factor, work-function, edge barrier and emission current density, will be investigated, using carbon nanotubes and graphene as examples. A multi-scale algorithm basing on density functional theory is introduced. We will argue that such a first principle approach is necessary and appropriate for field emission of nano-structures, not only for a more accurate quantitative description, but, more importantly, for deeper insight into field emission. - Highlights: • Applications of DFT to electron field emission of nano-structures are reviewed. • Fundamental concepts of field emission are re-visited with emphasis on the many-body effects. • New insights to field emission of nano-structures are obtained by multi-scale DFT calculations. • It is shown that the exchange–correlation effect on the emission barrier is significant. • Spontaneous symmetry breaking in field emission of CNT has been predicted.

  6. Relation of a unified quantum field theory of spinors to the structure of general relativity

    International Nuclear Information System (INIS)

    Kober, Martin

    2009-01-01

    Based on a unified quantum field theory of spinors assumed to describe all matter fields and their interactions we construct the space-time structure of general relativity according to a general connection within the corresponding spinor space. The tetrad field and the corresponding metric field are composed from a space-time dependent basis of spinors within the internal space of the fundamental matter field. Similar to twistor theory the Minkowski signature of the space-time metric is related to this spinor nature of elementary matter, if we assume the spinor space to be endowed with a symplectic structure. The equivalence principle and the property of background independence arise from the fact that all elementary fields are composed from the fundamental spinor field. This means that the structure of space-time according to general relativity seems to be a consequence of a fundamental theory of matter fields and not a presupposition as in the usual setting of relativistic quantum field theories.

  7. Global enhancement and structure formation of the magnetic field in spiral galaxies

    Science.gov (United States)

    Khoperskov, Sergey A.; Khrapov, Sergey S.

    2018-01-01

    In this paper we study numerically large-scale magnetic field evolution and its enhancement in gaseous disks of spiral galaxies. We consider a set of models with the various spiral pattern parameters and the initial magnetic field strength with taking into account gas self-gravity and cooling and heating processes. In agreement with previous studies we find out that galactic magnetic field is mostly aligned with gaseous structures, however small-scale gaseous structures (spurs and clumps) are more chaotic than the magnetic field structure. In spiral arms magnetic field often coexists with the gas distribution, in the inter-arm region we see filamentary magnetic field structure. These filaments connect several isolated gaseous clumps. Simulations reveal the presence of the small-scale irregularities of the magnetic field as well as the reversal of magnetic field at the outer edge of the large-scale spurs. We provide evidences that the magnetic field in the spiral arms has a stronger mean-field component, and there is a clear inverse correlation between gas density and plasma-beta parameter, compared to the rest of the disk with a more turbulent component of the field and an absence of correlation between gas density and plasma-beta. We show the mean field growth up to >3-10 μG in the cold gas during several rotation periods (>500-800 Myr), whereas ratio between azimuthal and radial field is equal to >4/1. We find an enhancement of random and ordered components of the magnetic field. Mean field strength increases by a factor of >1.5-2.5 for models with various spiral pattern parameters. Random magnetic field component can reach up to 25% from the total strength. By making an analysis of the time-dependent evolution of the radial Poynting flux, we point out that the magnetic field strength is enhanced more strongly at the galactic outskirts which is due to the radial transfer of magnetic energy by the spiral arms pushing the magnetic field outward. Our results also

  8. [Disease mongering and bipolar disorder in Japan].

    Science.gov (United States)

    Ihara, Hiroshi

    2011-01-01

    Frequently used in a pejorative sense, "disease mongering" connotes a widening of the diagnostic boundaries of illness. Pharmaceutical companies conduct disease awareness campaigns on the pretext of educating the public about the prevention of illness or the promotion of health. Encouraged by disease awareness advertisements, people gradually become filled with concern that they are ill and need medical treatment. As a result, pharmacotherapy is increasingly being applied to ever-milder conditions, leading to potentially unnecessary medication, wasted resources, and even adverse side effects. Among all fields of clinical medicine, psychiatry is undoubtedly the most vulnerable to the danger of disease mongering. In Japan, depression provides the most drastic example of the impact of disease awareness campaigns on the number of patients seeking treatment. Until the late 1990s, Japanese psychiatrists focused almost exclusively on psychosis and endogenous depression, the latter being severe enough to require conventional forms of antidepressants, known as tricyclic antidepressants, and even hospitalization. At this time, people's attitude toward depression was generally unfavorable. Indeed, the Japanese word for clinical depression, utubyo, has a negative connotation, implying severe mental illness. This situation, however, changed immediately after fluvoxiamine (Luvox-Fujisawa, Depromel-Meiji Seika), the first selective serotonin re-uptake inhibitor (SSRI) to receive approval in Japan, was introduced in 1999. In order to aid the drug's acceptance by the Japanese public, pharmaceutical companies began using the catchphrase kokoro no kaze, which literally means "a cold of the soul". Thus armed with this phrase, the pharmaceutical industry embarked on a campaign to lessen the stigma surrounding depression. According to national data from the Ministry of Health and Welfare, the number of patients with a diagnosis of mood disorder increased from 327,000 in 1999 to 591

  9. High accuracy electromagnetic field solvers for cylindrical waveguides and axisymmetric structures using the finite element method

    International Nuclear Information System (INIS)

    Nelson, E.M.

    1993-12-01

    Some two-dimensional finite element electromagnetic field solvers are described and tested. For TE and TM modes in homogeneous cylindrical waveguides and monopole modes in homogeneous axisymmetric structures, the solvers find approximate solutions to a weak formulation of the wave equation. Second-order isoparametric lagrangian triangular elements represent the field. For multipole modes in axisymmetric structures, the solver finds approximate solutions to a weak form of the curl-curl formulation of Maxwell's equations. Second-order triangular edge elements represent the radial (ρ) and axial (z) components of the field, while a second-order lagrangian basis represents the azimuthal (φ) component of the field weighted by the radius ρ. A reduced set of basis functions is employed for elements touching the axis. With this basis the spurious modes of the curl-curl formulation have zero frequency, so spurious modes are easily distinguished from non-static physical modes. Tests on an annular ring, a pillbox and a sphere indicate the solutions converge rapidly as the mesh is refined. Computed eigenvalues with relative errors of less than a few parts per million are obtained. Boundary conditions for symmetric, periodic and symmetric-periodic structures are discussed and included in the field solver. Boundary conditions for structures with inversion symmetry are also discussed. Special corner elements are described and employed to improve the accuracy of cylindrical waveguide and monopole modes with singular fields at sharp corners. The field solver is applied to three problems: (1) cross-field amplifier slow-wave circuits, (2) a detuned disk-loaded waveguide linear accelerator structure and (3) a 90 degrees overmoded waveguide bend. The detuned accelerator structure is a critical application of this high accuracy field solver. To maintain low long-range wakefields, tight design and manufacturing tolerances are required

  10. Recent Advances in the Study of Bipolar/Rod-Shaped Microglia and their Roles in Neurodegeneration

    Directory of Open Access Journals (Sweden)

    Ngan Pan Bennett Au

    2017-05-01

    Full Text Available Microglia are the resident immune cells of the central nervous system (CNS and they contribute to primary inflammatory responses following CNS injuries. The morphology of microglia is closely associated with their functional activities. Most previous research efforts have attempted to delineate the role of ramified and amoeboid microglia in the pathogenesis of neurodegenerative diseases. In addition to ramified and amoeboid microglia, bipolar/rod-shaped microglia were first described by Franz Nissl in 1899 and their presence in the brain was closely associated with the pathology of infectious diseases and sleeping disorders. However, studies relating to bipolar/rod-shaped microglia are very limited, largely due to the lack of appropriate in vitro and in vivo experimental models. Recent studies have reported the formation of bipolar/rod-shaped microglia trains in in vivo models of CNS injury, including diffuse brain injury, focal transient ischemia, optic nerve transection and laser-induced ocular hypertension (OHT. These bipolar/rod-shaped microglia formed end-to-end alignments in close proximity to the adjacent injured axons, but they showed no interactions with blood vessels or other types of glial cell. Recent studies have also reported on a highly reproducible in vitro culture model system to enrich bipolar/rod-shaped microglia that acts as a powerful tool with which to characterize this form of microglia. The molecular aspects of bipolar/rod-shaped microglia are of great interest in the field of CNS repair. This review article focuses on studies relating to the morphology and transformation of microglia into the bipolar/rod-shaped form, along with the differential gene expression and spatial distribution of bipolar/rod-shaped microglia in normal and pathological CNSs. The spatial arrangement of bipolar/rod-shaped microglia is crucial in the reorganization and remodeling of neuronal and synaptic circuitry following CNS injuries. Finally, we

  11. Direct Visualization of Local Electromagnetic Field Structures by Scanning Transmission Electron Microscopy.

    Science.gov (United States)

    Shibata, Naoya; Findlay, Scott D; Matsumoto, Takao; Kohno, Yuji; Seki, Takehito; Sánchez-Santolino, Gabriel; Ikuhara, Yuichi

    2017-07-18

    The functional properties of materials and devices are critically determined by the electromagnetic field structures formed inside them, especially at nanointerface and surface regions, because such structures are strongly associated with the dynamics of electrons, holes and ions. To understand the fundamental origin of many exotic properties in modern materials and devices, it is essential to directly characterize local electromagnetic field structures at such defect regions, even down to atomic dimensions. In recent years, rapid progress in the development of high-speed area detectors for aberration-corrected scanning transmission electron microscopy (STEM) with sub-angstrom spatial resolution has opened new possibilities to directly image such electromagnetic field structures at very high-resolution. In this Account, we give an overview of our recent development of differential phase contrast (DPC) microscopy for aberration-corrected STEM and its application to many materials problems. In recent years, we have developed segmented-type STEM detectors which divide the detector plane into 16 segments and enable simultaneous imaging of 16 STEM images which are sensitive to the positions and angles of transmitted/scattered electrons on the detector plane. These detectors also have atomic-resolution imaging capability. Using these segmented-type STEM detectors, we show DPC STEM imaging to be a very powerful tool for directly imaging local electromagnetic field structures in materials and devices in real space. For example, DPC STEM can clearly visualize the local electric field variation due to the abrupt potential change across a p-n junction in a GaAs semiconductor, which cannot be observed by normal in-focus bright-field or annular type dark-field STEM imaging modes. DPC STEM is also very effective for imaging magnetic field structures in magnetic materials, such as magnetic domains and skyrmions. Moreover, real-time imaging of electromagnetic field structures can

  12. Ballistic charge carrier transmission through graphene multi-barrier structures in uniform magnetic field

    International Nuclear Information System (INIS)

    Zubarev, A; Dragoman, D

    2014-01-01

    We investigate charge carrier transport in graphene multi-barrier structures placed in a uniform magnetic field. The transmission coefficient is found analytically by generalizing the transfer matrix method for the case of graphene regions subjected to a uniform magnetic field. The transmission coefficient through the structure can be modulated by varying the gate voltages, the magnetic field and/or the width of the gated regions. Such a configuration could be used in multiple-valued logic circuits, since it has several output states with discrete and easily selectable transmission/current values. (paper)

  13. Phase Structure Of Fuzzy Field Theories And Multi trace Matrix Models

    International Nuclear Information System (INIS)

    Tekel, J.

    2015-01-01

    We review the interplay of fuzzy field theories and matrix models, with an emphasis on the phase structure of fuzzy scalar field theories. We give a self-contained introduction to these topics and give the details concerning the saddle point approach for the usual single trace and multi trace matrix models. We then review the attempts to explain the phase structure of the fuzzy field theory using a corresponding random matrix ensemble, showing the strength and weaknesses of this approach. We conclude with a list of challenges one needs to overcome and the most interesting open problems one can try to solve. (author)

  14. The Effect of a Guide Field on the Structures of Magnetic Islands: 2D PIC Simulations

    Science.gov (United States)

    Huang, C.; Lu, Q.; Lu, S.; Wang, P.; Wang, S.

    2014-12-01

    Magnetic island plays an important role in magnetic reconnection. Using a series of 2D PIC simulations, we investigate the magnetic structures of a magnetic island formed during multiple X-line magnetic reconnection, considering the effects of the guide field in symmetric and asymmetric current sheets. In a symmetric current sheet, the current in the direction forms a tripolar structure inside a magnetic island during anti-parallel reconnection, which results in a quadrupole structure of the out-of-plane magnetic field. With the increase of the guide field, the symmetry of both the current system and out-of-plane magnetic field inside the magnetic island is distorted. When the guide field is sufficiently strong, the current forms a ring along the magnetic field lines inside magnetic island. At the same time, the current carried by the energetic electrons accelerated in the vicinity of the X lines forms another ring at the edge of the magnetic island. Such a dual-ring current system enhance the out-of-plane magnetic field inside the magnetic island with a dip in the center of the magnetic island. In an asymmetric current sheet, when there is no guide field, electrons flows toward the X lines along the separatrices from the side with a higher density, and are then directed away from the X lines along the separatrices to the side with a lower density. The formed current results in the enhancement of the out-of-plane magnetic field at one end of the magnetic island, and the attenuation at the other end. With the increase of the guide field, the structures of both the current system and the out-of-plane magnetic field are distorted.

  15. Structural-design considerations for the FED 50-kA equilibrium field coils

    International Nuclear Information System (INIS)

    Buchanan, G.; Bennett, J.G.

    1983-01-01

    The structural support system for two equilibrium field coil conductor concepts is considered for the fusion energy design (FED) 8/10T baseline magnetic-fusion system. Both conductor concepts are discussed. Results indicate that regardless of the conductor concept employed, an external support beam/frame structural system is required to equilibrate the accumulative loadings

  16. Cryogenic magnet case and distributed structural materials for high-field superconducting magnets

    International Nuclear Information System (INIS)

    Summers, L.T.; Miller, J.R.; Kerns, J.A.; Myall, J.O.

    1987-01-01

    The superconducting magnets of the Tokamak Ignition/Burn Experimental Reactor (TIBER II) will generate high magnetic fields over large bores. The resulting electromagnetic forces require the use of large volumes of distributed steel and thick magnet case for structural support. Here we review the design allowables, calculated loads and forces, and structural materials selection for TIBER II. 7 refs., 2 figs., 3 tabs

  17. Characterization of high-power RF structures using time-domain field codes

    International Nuclear Information System (INIS)

    Shang, C.C.; DeFord, J.F.; Swatloski, T.L.

    1992-01-01

    We have modeled gyrotron windows and gyrotron amplifier sever structures for TE modes in the 100--150 GHz range and have computed the reflection and transmission characteristics from the field data. Good agreement with frequency domain codes and analytic analysis have been obtained for some simple geometries. We present results for realistic structures with lousy coatings and describe implementation of microwave diagnostics

  18. Assessment of radiation fields from neutron irradiated structural components of the 40 MW research reactor CIRUS

    International Nuclear Information System (INIS)

    Sankaranarayanan, S.; Sharma, S.K.

    1993-01-01

    The paper summarizes the results of an assessment of the radiation fields from the long-lived neutron activation products (including the decay chain products) in the various structural components of the CIRUS reactor. Special attention is given for the analysis of neutron activation of impurity elements present in the materials of the structure. 16 refs, 4 figs, 4 tabs

  19. Optical and field emission properties of layer-structure GaN nanowires

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Zhen [Science School, Xi’an University of Technology, Xi’an 710048 (China); School of automation and Information Engineering, Xi’an University of Technology, Xi’an 710048 (China); Li, Enling, E-mail: Lienling@xaut.edu.cn [Science School, Xi’an University of Technology, Xi’an 710048 (China); Shi, Wei; Ma, Deming [Science School, Xi’an University of Technology, Xi’an 710048 (China)

    2014-08-15

    Highlights: • The layer-structure GaN nanowires with hexagonal-shaped cross-sections are produced via a process based on the CVD method. • The diameter of the layer-structure GaN nanowire gradually decreases from ∼500 nm to ∼200 nm along the wire axis. • The layer-structure GaN nanowire film possesses good field emission property. - Abstract: A layer-structure gallium nitride (GaN) nanowires, grown on Pt-coated n-type Si (1 1 1) substrate, have been synthesized using chemical vapor deposition (CVD). The results show: (1) SEM indicates that the geometry structure is layer-structure. HRTEM indicates that GaN nanowire’s preferential growth direction is along [0 0 1] direction. (2) The room temperature PL emission spectrum of the layer-structure GaN nanowires has a peak at 375 nm, which proves that GaN nanowires have potential application in light-emitting nano-devices. (3) Field-emission measurements show that the layer-structure GaN nanowires film has a low turn-on field of 4.39 V/μm (at room temperature), which is sufficient for electron emission devices, field emission displays and vacuum nano-electronic devices. The growth mechanism for GaN nanowires has also been discussed briefly.

  20. Sexual risk behaviors among women with bipolar disorder.

    Science.gov (United States)

    Marengo, Eliana; Martino, Diego J; Igoa, Ana; Fassi, Guillermo; Scápola, María; Urtueta Baamonde, Mariana; Strejilevich, Sergio A

    2015-12-30

    The aim of this study was to investigate sexual health and sexual risk behaviors for sexually transmitted infections (STI) among women with bipolar disorder (BDW). Sixty-three euthymic women diagnosed with bipolar disorder type I, II or not otherwise specified were included and matched with a control group of 63 healthy women. Demographic and clinical data, structured sexual health measures and extensive assessment of sexual risk behavior were obtained and compared between groups. BDW had casual partners, were in non-monogamous sexual partnerships and had sex with partners with unknown HIV condition more frequently than healthy control women. History of two or more STI was more frequent among BDW. Inclusion of sexual behavior risk assessment among BDW in treatment is necessary to better identify those women with higher risk for STI and to take measures to improve their sexual health. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  1. A Model for Periodic Nonlinear Electric Field Structures in Space Plasmas

    International Nuclear Information System (INIS)

    Qureshi, M.N.S.; Shi Jiankui; Liu Zhenxing

    2009-01-01

    In this study, we present a physical model to explain the generation mechanism of nonlinear periodic waves with a large amplitude electric field structures propagating obliquely and exactly parallel to the magnetic field. The 'Sagdeev potential' from the MHD equations is derived and the nonlinear electric field waveforms are obtained when the Mach number, direction of propagation, and the initial electric field satisfy certain plasma conditions. For the parallel propagation, the amplitude of the electric field waves with ion-acoustic mode increases with the increase of initial electric field and Mach number but its frequency decreases with the increase of Mach number. The amplitude and frequency of the electric field waves with ion-cyclotron mode decrease with the increase of Mach number and become less spiky, and its amplitude increases with the increase of initial electric field. For the oblique propagation, only periodic electric field wave with an ion-cyclotron mode obtained, its amplitude and frequency increase with the increase of Mach number and become spiky. From our model the electric field structures show periodic, spiky, and saw-tooth behaviours corresponding to different plasma conditions.

  2. European Network of Bipolar Research Expert Centre (ENBREC)

    DEFF Research Database (Denmark)

    Henry, Chantal; Andreassen, Ole A; Barbato, Angelo

    2013-01-01

    Bipolar disorders rank as one of the most disabling illnesses in working age adults worldwide. Despite this, the quality of care offered to patients with this disorder is suboptimal, largely due to limitations in our understanding of the pathology. Improving this scenario requires the development...... centres across Europe can collaborate on a wide range of basic science and clinical programmes using shared protocols. This paper is to describe the network and how it aims to improve the quality and effectiveness of research in a neglected priority area....... of a critical mass of expertise and multicentre collaborative projects. Within the framework of the European FP7 programme, we developed a European Network of Bipolar Research Expert Centres (ENBREC) designed specifically to facilitate EU-wide studies. ENBREC provides an integrated support structure...... facilitating research on disease mechanisms and clinical outcomes across six European countries (France, Germany, Italy, Norway, Spain and the UK). The centres are adopting a standardised clinical assessment that explores multiple aspects of bipolar disorder through a structured evaluation designed to inform...

  3. Diffusion Entropy: A Potential Neuroimaging Biomarker of Bipolar Disorder in the Temporal Pole.

    Science.gov (United States)

    Spuhler, Karl; Bartlett, Elizabeth; Ding, Jie; DeLorenzo, Christine; Parsey, Ramin; Huang, Chuan

    2018-02-01

    Despite much research, bipolar depression remains poorly understood, with no clinically useful biomarkers for its diagnosis. The paralimbic system has become a target for biomarker research, with paralimbic structural connectivity commonly reported to distinguish bipolar patients from controls in tractography-based diffusion MRI studies, despite inconsistent findings in voxel-based studies. The purpose of this analysis was to validate existing findings with traditional diffusion MRI metrics and investigate the utility of a novel diffusion MRI metric, entropy of diffusion, in the search for bipolar depression biomarkers. We performed group-level analysis on 9 un-medicated (6 medication-naïve; 3 medication-free for at least 33 days) bipolar patients in a major depressive episode and 9 matched healthy controls to compare: (1) average mean diffusivity (MD) and fractional anisotropy (FA) and; (2) MD and FA histogram entropy-a statistical measure of distribution homogeneity-in the amygdala, hippocampus, orbitofrontal cortex and temporal pole. We also conducted classification analyses with leave-one-out and separate testing dataset (N = 11) approaches. We did not observe statistically significant differences in average MD or FA between the groups in any region. However, in the temporal pole, we observed significantly lower MD entropy in bipolar patients; this finding suggests a regional difference in MD distributions in the absence of an average difference. This metric allowed us to accurately characterize bipolar patients from controls in leave-one-out (accuracy = 83%) and prediction (accuracy = 73%) analyses. This novel application of diffusion MRI yielded not only an interesting separation between bipolar patients and healthy controls, but also accurately classified bipolar patients from controls. © 2017 Wiley Periodicals, Inc.

  4. Comorbidity of Anxiety Disorders and Substance Abusewith Bipolar Mood Disorders and Relationship with ClinicalCourse

    Directory of Open Access Journals (Sweden)

    Ali Reza Shafiee-Kandjani

    2009-12-01

    Full Text Available "n Objective: Patients with bipolar mood disorder constitute a relatively large number of individuals hospitalized in psychiatric hospitals. This disorder is highly co-morbid with other psychiatric disorders and may effect their clinical course. The goal of this study was to determine the co-occurrence rate of anxiety disorders and substance abuse with bipolar mood disorders and their impact on clinical course. "n Methods: 153 bipolar patients (type I were selected among the hospitalized patients at Razi Psychiatric Hospital in Tabriz, Iran, from September 2007 to October 2008 through convenience sampling method. The participants were evaluated by a structured clinical interview based on DSM-IV criteria (SCID, Hamilton Rating Scale for Depression (HRSD and Young Mania Rating Scale (YMRS. Results: Co-morbidity of anxiety disorders was 43% . Occurrence of anxiety disorders was 26% for obsessive-compulsive disorder, 24.8% for generalized anxiety disorder, 3.9% for phobia and 2% for panic disorder. Co-morbidity of substance abuse was 7.2% and the highest occurrence of substance abuse was 5.2% for alcoholism and 3.9% for opium. No significant difference was observed between the severity of disease and duration of hospitalization in bipolar patients with or without anxiety disorder. The severity of disease and duration of hospitalization in bipolar patients with substance abuse was higher compared to bipolar patients without substance abuse (P<0.05. "nConclusions: This study suggests that there is a high co-morbidity between anxiety disorders and substance abuse with bipolar disorder. Further, this study suggests that co-occurrence of substance abuse disorder with bipolar disorder increases the severity of the disease and duration of hospitalization.

  5. Factor analysis of temperament and personality traits in bipolar patients: Correlates with comorbidity and disorder severity.

    Science.gov (United States)

    Qiu, Frank; Akiskal, Hagop S; Kelsoe, John R; Greenwood, Tiffany A

    2017-01-01

    Temperament and personality traits have been suggested as endophenotypes for bipolar disorder based on several lines of evidence, including heritability. Previous work suggested an anxious-reactive factor identified across temperament and personality inventories that produced significant group discrimination and could potentially be useful in genetic analyses. We have attempted to further characterize this factor structure in a sample of bipolar patients. A sample of 1195 subjects with bipolar I disorder was evaluated, all with complete data available. Dimension reduction across two inventories identified 18 factors explaining 39% of the variance. The two largest factors reflected affective instability and general anxiety/worry, respectively. Subsequent analyses of the clinical features associated with bipolar disorder revealed specificity for the factors in a predictable pattern. Cluster analysis of the factors identified a subgroup defined by a strong lack of general anxiety and low affective instability represented by the first two factors. The remaining subjects could be distinguished into two clusters by the presence of either more positive characteristics, including persistence/drive, spirituality, expressivity, and humor, or more negative characteristics of depression and anxiety. These analyses involved bipolar I subjects only and must be extended to other bipolar spectrum diagnoses, unaffected relatives, and individuals at risk. These results suggest that temperament and personality measures access latent traits associated with important clinical features of bipolar disorder. By translating clinical variables into quantitative traits, we may identify subgroups of bipolar patients with distinct clinical profiles, thereby facilitating both individual treatment strategies and genetic analyses. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Bipolar patients' quality of life in mixed states: a preliminary qualitative study.

    Science.gov (United States)

    Lee Mortensen, Gitte; Vinberg, Maj; Lee Mortensen, Steen; Balslev Jørgensen, Martin; Eberhard, Jonas

    2015-01-01

    Approximately 20% of patients with bipolar disorder experience mixed states. Mixed states are associated with more comorbidity, poorer treatment response and prognosis, increased relapse rate, and decreased functioning. This study aimed to produce in-depth knowledge about bipolar patients' quality of life (QoL) and functioning related to mixed states. This study used qualitative research methods. A semi-structured interview guide based on a literature study was applied in interviews with 6 remitted bipolar I patients having experienced mixed states. A medical anthropological approach was applied to analyse the data. Participants described mixed states as worse than other bipolar disorder states and their residual symptoms were prolonged. Mixed states affected the functioning of patients in key life domains such as self-esteem, family, love and social life, physical well-being, and working capability. Mixed states may severely affect the QoL and functioning of bipolar patients. Our results indicate that improving these should be a main goal of patient treatment. With an aim of adequately identifying and treating mixed states, our findings highlight the need for knowledge about this particularly severe expression of bipolar disorder. These results should be confirmed in a larger sample of patients with varying socioeconomic status.

  7. Association between history of psychosis and cardiovascular disease in bipolar disorder.

    Science.gov (United States)

    Prieto, Miguel L; McElroy, Susan L; Hayes, Sharonne N; Sutor, Bruce; Kung, Simon; Bobo, William V; Fuentes, Manuel E; Cuellar-Barboza, Alfredo B; Crow, Scott; Ösby, Urban; Chauhan, Mohit; Westman, Jeanette; Geske, Jennifer R; Colby, Colin L; Ryu, Euijung; Biernacka, Joanna M; Frye, Mark A

    2015-08-01

    To determine whether clinical features of bipolar disorder, such as history of psychosis, and cardiovascular disease (CVD) risk factors contribute to a higher risk of CVD among patients with bipolar disorder. This cross-sectional study included a sample of 988 patients with bipolar I or bipolar II disorder or schizoaffective bipolar type confirmed by the Structured Clinical Interview for DSM-IV-TR disorders (SCID). Medical comorbidity burden was quantified utilizing the Cumulative Illness Severity Rating Scale (CIRS). This 13-item organ-based scale includes cardiac disease severity quantification. Confirmed by medical record review, patients who scored 1 (current mild or past significant problem) or higher in the cardiac item were compared by logistic regression to patients who scored 0 (no impairment), adjusting for CVD risk factors that were selected using a backwards stepwise approach or were obtained from the literature. In a multivariate model, age [odds ratio (OR) = 3.03, 95% confidence interval (CI): 1.66-5.54, p bipolar disorder may reflect higher illness severity with associated cardiac comorbidity. Further studies are encouraged to clarify the effect of the disease burden (i.e., depression), lifestyle, and treatment interventions (i.e., atypical antipsychotics) on this risk association. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Insight in bipolar mania: evaluation of its heterogeneity and correlation with clinical symptoms.

    Science.gov (United States)

    Silva, Rafael de Assis da; Mograbi, Daniel C; Bifano, Jaqueline; Santana, Cristina M T; Cheniaux, Elie

    2016-07-15

    Studies on insight in bipolar mania are not numerous and usually consider insight as a unitary construct. Evaluate how different facets of insight are affected in bipolar mania and investigate correlations between insight for each specific object in bipolar disorder and manic symptomatology. A group of 165 bipolar patients were followed during a year, with 51 patients having manic episodes according to DSM-IV-TR criteria. Patients underwent a clinical assessment and insight was evaluated through the Insight Scale for Affective Disorders. The study found that insight regarding symptoms is worse than insight of having bipolar disorder, social relationships and self esteem. Moreover, poor global insight (total ISAD) correlates with more severe changes in mood, speech and thought structure, with worse insight about symptoms correlating with the same alterations and also with more severe symptoms of agitation/energy. Although a large sample of bipolar patients was followed up, the final sample composed of patients with at least one manic episode was relatively smaller. Moreover, the fact that the study was performed in a university hospital may have led to selection biases. Results suggest that patients with BD are reasonably capable of identifying that their condition implies consequences but have more impaired awareness of their energy and activity levels. A lower level of insight specifically about symptoms correlates with more severe symptoms of agitation/energy, which suggests a psychomotor nucleus able to impair insight in mania. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. [Everyday stress, routines and bipolar spectrum].

    Science.gov (United States)

    Gindre, C; Swendsen, J

    2010-06-01

    Bipolar patients relapse more frequently under conditions of stress, even when compliant with prescribed medication. Although the biological bases of stress reactivity remain widely debated, the disruption of biological or circadian rhythms has been suggested as one possible mechanism through which stress increases the risk of episodes. This hypothesis has gained support from recent evidence demonstrating that the disruption of social rhythms is particularly implicated in the onset of manic episodes. However, it is currently unknown to what extent bipolar patients may differ from normal controls in terms of the basic prevalence and nature of daily life routines, or if such individuals are more sensitive to the disruption of such rhythms following exposure to stress. Using a dimensional perspective of bipolar disorder, 1728 French university students were first screened concerning diverse psychological and clinical characteristics. Two hundred and twelve individuals at high or low-risk for mood and substance use disorders were then invited to participate in a week-long period of ambulatory monitoring using the experience sampling method (ESM). During this phase, participants were given a preprogrammed PDA microcomputer which provided ambulatory assessments of behaviour and stress at fixed intervals (randomized across participants). At the end of the ESM phase, the microcomputers were collected and structured diagnostic interviews were administered to each participant. For the purposes of the current study, analyses focused on a subsample of 92 individuals, reflecting the 28 participants who met lifetime criteria for a manic (n=15) or hypomanic episode (n=13), and the 64 individuals who were free of any lifetime disorder. Data were analyzed using hierarchical nonlinear (Bernoulli) models for repeated measures. Covariates included age, sex, frequency of substance use and cognitive vulnerabilities assessed at screening. A Bonferroni correction was applied to adjust

  10. Structure and viscosity of a transformer oil-based ferrofluid under an external electric field

    Energy Technology Data Exchange (ETDEWEB)

    Rajnak, M., E-mail: rajnak@saske.sk [Institute of Experimental Physics SAS, Watsonova 47, 04001 Košice (Slovakia); Faculty of Electrical Engineering and Informatics, Technical University of Košice, Letná 9, 04200 Košice (Slovakia); Timko, M.; Kopcansky, P.; Paulovicova, K. [Institute of Experimental Physics SAS, Watsonova 47, 04001 Košice (Slovakia); Tothova, J.; Kurimsky, J.; Dolnik, B.; Cimbala, R. [Faculty of Electrical Engineering and Informatics, Technical University of Košice, Letná 9, 04200 Košice (Slovakia); Avdeev, M.V. [Joint Institute for Nuclear Research, Joliot-Curie 6, Moscow region, 141980 Dubna (Russian Federation); Petrenko, V.I. [Joint Institute for Nuclear Research, Joliot-Curie 6, Moscow region, 141980 Dubna (Russian Federation); Taras Shevchenko Kyiv National University, Volodymyrska Street 64, 01601 Kyiv (Ukraine); Feoktystov, A. [Jülich Centre for Neutron Science (JCNS) at Heinz Maier-Leibnitz Zentrum (MLZ), Forschungszentrum Jülich GmbH, Lichtenbergstr. 1, 85748 Garching (Germany)

    2017-06-01

    Various structural changes of ferrofluids have been intensively studied under external magnetic fields. In this work we present an experimental evidence of similar changes induced by an electric field. In the context of the electric field effect on ferrofluids structure, we studied a simple ferrofluid consisting of iron oxide nanoparticles coated with oleic acid and dispersed in transformer oil. The structural changes have been observed both on macroscopic and microscopic scale. We also demonstrate a remarkable impact of the electric field on the ferrofluid viscosity in relation to the reported structural changes. It was found that the electric field induced viscosity changes are analogous to the magnetoviscous effect. These changes and the electroviscous effect are believed to stem from the dielectric permittivity contrast between the iron oxide nanoparticles and transformer oil, giving rise to the effective electric polarization of the nanoparticles. It is highlighted that this electrorheological effect should be considered in studies of ferrofluids for high voltage engineering applications, as it can have impact on the thermomagnetic convection or the dielectric breakdown performance. - Highlights: • An experimental evidence of the electric field induced structural changes in a ferrofluid is presented. • An electroviscous effect in the transformer oil-based ferrofluid is shown. • The dielectric contrast between the particles and the carrier fluid is the key factor. • The potential impact on the thermomagnetic convection of ferrofluids in power transformers is highlighted.

  11. Virtual Field and Internal Structure of Half-Dressed Extended Particles

    International Nuclear Information System (INIS)

    Compagno, G.; Persico, F.

    1988-01-01

    A new method is proposed to investigate the internal geometrical structure of an extended particle surrounded by an incomplete virtual dressing field. This method involves analysing the time-dependent virtual field at large distances from the particle, without any direct interaction with the latter. As an example, the pulselike, time-dependent virtual field of an extended QED source is investigated using a model which has a well-known counterpart in meson theory. In the framework of nonrelativistic QED it is shown that, contrary to the case of a point source, the pulse has finite width and height. For the case of a spherically symmetric source, it is explicitly shown that the width and shape of the pulse at distance r from the particle depend on the parameters determining the space structure of the source. It is concluded that the study of the field of half-dressed particles may provide a new method to investigate their internal structure

  12. Coherent gradient sensing method for measuring thermal stress field of thermal barrier coating structures

    Directory of Open Access Journals (Sweden)

    Kang Ma

    2017-01-01

    Full Text Available Coherent gradient sensing (CGS method can be used to measure the slope of a reflective surface, and has the merits of full-field, non-contact, and real-time measurement. In this study, the thermal stress field of thermal barrier coating (TBC structures is measured by CGS method. Two kinds of powders were sprayed onto Ni-based alloy using a plasma spraying method to obtain two groups of film–substrate specimens. The specimens were then heated with an oxy-acetylene flame. The resulting thermal mismatch between the film and substrate led to out-of-plane deformation of the specimen. The deformation was measured by the reflective CGS method and the thermal stress field of the structure was obtained through calibration with the help of finite element analysis. Both the experiment and numerical results showed that the thermal stress field of TBC structures can be successfully measured by CGS method.

  13. On the structure of the magnetic field in the large Magellanic Cloud

    International Nuclear Information System (INIS)

    Isserstedt, J.; Reinhardt, M.

    1976-01-01

    The magnetic field structure in the LMC is re-analysed using the polarization data given by Mathewson and Ford and combining them with recent photometric and spectroscopic observations of supergiants. The following results were derived: (i) The ratio of the degree of polarization to absorption is the same as in our Galaxy. (ii) Accepting the galactic foreground correction by Mathewson and Ford after a critical discussion, the existence of a uniform field component in the direction to the SMC is confirmed. The field is roughly perpendicular to the bars of the LMC and SMC. (iii) The magnetic field is not concentrated towards the young spiral arms found by Schmidt-Kaler and Isserstedt. (iv) A radial component of the magnetic field with respect to 30 Dor is discovered. This radial field is dominating the polarizations in the surroundings of 30 Dor up to an angular distance of 1 0 . From the orientations of the polarization vectors the supergiant H II region N 157 is determined as the centre of the magnetic field. (v) The observed radial field is interpreted as a dipole field with the field axis perpendicular to the plane of symmetry of the LMC. The strong and uniform field within N 157 is due to the projection of the field along the dipole axis. (vi) The space orientation and sense of rotation is discussed. It seems that the LMC rotates with leading spiral arms. (author)

  14. Simulations of fine structures on the zero field steps of Josephson tunnel junctions

    DEFF Research Database (Denmark)

    Scheuermann, M.; Chi, C. C.; Pedersen, Niels Falsig

    1986-01-01

    Fine structures on the zero field steps of long Josephson tunnel junctions are simulated for junctions with the bias current injected into the junction at the edges. These structures are due to the coupling between self-generated plasma oscillations and the traveling fluxon. The plasma oscillations...... are generated by the interaction of the bias current with the fluxon at the junction edges. On the first zero field step, the voltages of successive fine structures are given by Vn=[h-bar]/2e(2omegap/n), where n is an even integer. Applied Physics Letters is copyrighted by The American Institute of Physics....

  15. Tailored optical vector fields for ultrashort-pulse laser induced complex surface plasmon structuring.

    Science.gov (United States)

    Ouyang, J; Perrie, W; Allegre, O J; Heil, T; Jin, Y; Fearon, E; Eckford, D; Edwardson, S P; Dearden, G

    2015-05-18

    Precise tailoring of optical vector beams is demonstrated, shaping their focal electric fields and used to create complex laser micro-patterning on a metal surface. A Spatial Light Modulator (SLM) and a micro-structured S-waveplate were integrated with a picosecond laser system and employed to structure the vector fields into radial and azimuthal polarizations with and without a vortex phase wavefront as well as superposition states. Imprinting Laser Induced Periodic Surface Structures (LIPSS) elucidates the detailed vector fields around the focal region. In addition to clear azimuthal and radial plasmon surface structures, unique, variable logarithmic spiral micro-structures with a pitch Λ ∼1μm, not observed previously, were imprinted on the surface, confirming unambiguously the complex 2D focal electric fields. We show clearly also how the Orbital Angular Momentum(OAM) associated with a helical wavefront induces rotation of vector fields along the optic axis of a focusing lens and confirmed by the observed surface micro-structures.

  16. On the structure of a magnetic field and its evolution in the vicinity of sunspots

    International Nuclear Information System (INIS)

    Gopasyuk, S.I.; Kartashova, L.G.

    1981-01-01

    The structure of magnetic field and its evolution around single large sunspots has been studied. For this purpose observational data of the longitudinal magnetic field on the photospheric level and hsub(α) filtergrams for 18 active regions have been used. It is shown that there are characteristic directions corresponding to the transition of the spot field without sign change into an extended region of the same polarity and coinciding with extended (100000-300000 km) systems of filamentary feature chains of the fine chromospheric structure in active region. The horizontal magnetic f+eld component of the spot (systems of filamentary feature chains of the fine chromospheric structure) disappears on an extended region of chromospheric surface in the direction, where the satellite field (the field of opposite polarity) appears near its boundary. On the other hand, when satellite field disappears at some direction from the spot the transversal magnetic field appears on the extended surface region of the chromosphere keeping the same direction. One of the possible causes of disappearance of the transversal magnetic field on an extended region in the chromosphere might be the reconnection of magnetic lines of force [ru

  17. Impact of Brake Pad Structure on Temperature and Stress Fields of Brake Disc

    OpenAIRE

    Wang, Guoshun; Fu, Rong

    2013-01-01

    Utilizing ABAQUS finite element software, the study established the relationship between a brake pad structure and distributions of temperature and thermal stress on brake disc. By introducing radial structure factor and circular structure factor concepts, the research characterized the effect of friction block radial and circumferential arrangement on temperature field of the brake disc. A method was proposed for improving heat flow distribution of the brake disc through optimizing the posit...

  18. 3D Biomimetic Magnetic Structures for Static Magnetic Field Stimulation of Osteogenesis

    OpenAIRE

    Irina Alexandra Paun; Roxana Cristina Popescu; Bogdan Stefanita Calin; Cosmin Catalin Mustaciosu; Maria Dinescu; Catalin Romeo Luculescu

    2018-01-01

    We designed, fabricated and optimized 3D biomimetic magnetic structures that stimulate the osteogenesis in static magnetic fields. The structures were fabricated by direct laser writing via two-photon polymerization of IP-L780 photopolymer and were based on ellipsoidal, hexagonal units organized in a multilayered architecture. The magnetic activity of the structures was assured by coating with a thin layer of collagen-chitosan-hydroxyapatite-magnetic nanoparticles composite. In vitro experime...

  19. Effects of seed magnetic fields on magnetohydrodynamic implosion structure and dynamics

    KAUST Repository

    Mostert, W.

    2014-12-01

    The effects of various seed magnetic fields on the dynamics of cylindrical and spherical implosions in ideal magnetohydrodynamics are investigated. Here, we present a fundamental investigation of this problem utilizing cylindrical and spherical Riemann problems under three seed field configurations to initialize the implosions. The resulting flows are simulated numerically, revealing rich flow structures, including multiple families of magnetohydrodynamic shocks and rarefactions that interact non-linearly. We fully characterize these flow structures, examine their axi- and spherisymmetry-breaking behaviour, and provide data on asymmetry evolution for different field strengths and driving pressures for each seed field configuration. We find that out of the configurations investigated, a seed field for which the implosion centre is a saddle point in at least one plane exhibits the least degree of asymmetry during implosion.

  20. Magnetic field structure near the plasma boundary in helical systems and divertor tokamaks

    International Nuclear Information System (INIS)

    Nagasaki, Kazunobu; Itoh, Kimitaka

    1990-02-01

    Magnetic field structure of the scrape off layer (SOL) region in both helical systems and divertor tokamaks is studied numerically by using model fields. The connection length of the field line to the wall is calculated. In helical systems, the connection length, L, has a logarithmic dependence on the distance from the outermost magnetic surface or that from the residual magnetic islands. The effect of axisymmetric fields on the field structure is also determined. In divertor tokamaks, the connection length also has logarithmic properties near the separatrix. Even when the perturbations, which resonate to rational surfaces near the plasma boundary, are added, logarithmic properties still remain. We compare the connection length of torsatron/helical-heliotron systems with that of divertor tokamaks. It is found that the former is shorter than the latter by one order magnitude with similar aspect ratio. (author)

  1. Radiation effects on JFETS, MOSFETS, and bipolar transistors, as related to SSC circuit design

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, E J; Gray, B; Wu, A [Dept. of Electrical and Computer Engineering, Univ. of Tennessee, Knoxville, TN (United States); Alley, G T; Britton, Jr, C L [Oak Ridge National Lab., TN (United States); Skubic, P L [Univ. of Oklahoma, Dept. of Physics and Astronomy, Norman, OK (United States)

    1991-10-01

    Some results of radiation effects on selected junction field-effect transistors, MOS field-effect transistors, and bipolar junction transistors are presented. The evaluations include dc parameters, as well as capacitive variations and noise evaluations. The tests are made at the low current and voltage levels (in particular at currents {<=} 1 mA) that are essential for the low-power regimes required by SSC circuitry. Detailed noise data are presented both before and after 5-Mrad (gamma) total-dose exposure. SPICE radiation models for three high-frequency bipolar processes are compared for a typical charge-sensitive preamplifier. (orig.).

  2. Steady state models for filamentary plasma structures associated with force free magnetic fields

    International Nuclear Information System (INIS)

    Marklund, G.

    1978-05-01

    This paper presents a model for filamentary plasma structures associated with force-free magnetic fields. A homogenous electric field parallel to the symmetry axis of the magnetic field is assumed. Under the influence of these fields, the plasma will drift radially inwards resulting in an accumulation of plasma in the central region. We assume recombination losses to keep the central plasma density at a finite value, and the recombined plasma i.e. the neutrals to diffuse radially outwards. Plasma density and some neutral gas density distributions for a steady state situation are calculated for various cases

  3. A YinYang bipolar fuzzy cognitive TOPSIS method to bipolar disorder diagnosis.

    Science.gov (United States)

    Han, Ying; Lu, Zhenyu; Du, Zhenguang; Luo, Qi; Chen, Sheng

    2018-05-01

    Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder. Thus, in this paper, a YinYang bipolar fuzzy multi-criteria group decision making method to bipolar disorder clinical diagnosis is developed. Comparing with the existing method, the new one is more comprehensive. The merits of the new method are listed as follows: First of all, multi-criteria group decision making method is introduced into bipolar disorder diagnosis for considering different symptoms and multiple doctors' opinions. Secondly, the discreet diagnosis principle is adopted by the revised TOPSIS method. Last but not the least, YinYang bipolar fuzzy cognitive map is provided for the understanding of interrelations among symptoms. The illustrated case demonstrates the feasibility, validity, and necessity of the theoretical results obtained. Moreover, the comparison analysis demonstrates that the diagnosis result is more accurate, when interrelations about symptoms are considered in the proposed method. In a conclusion, the main contribution of this paper is to provide a comprehensive mathematical approach to improve the accuracy of bipolar disorder clinical diagnosis, in which both bipolarity and complexity are considered. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Staging in bipolar disorder: from theoretical framework to clinical utility.

    Science.gov (United States)

    Berk, Michael; Post, Robert; Ratheesh, Aswin; Gliddon, Emma; Singh, Ajeet; Vieta, Eduard; Carvalho, Andre F; Ashton, Melanie M; Berk, Lesley; Cotton, Susan M; McGorry, Patrick D; Fernandes, Brisa S; Yatham, Lakshmi N; Dodd, Seetal

    2017-10-01

    Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures. These include progressive biochemical, neuroimaging and cognitive changes, and potentially stage-specific differences in response to pharmacological and psychosocial treatments. Mechanistically, staging models imply the presence of an active disease process that, if not remediated, can lead to neuroprogression, a more malignant disease course and functional deterioration. Biological elements thought to be operative in bipolar disorder include a genetic diathesis, physical and psychic trauma, epigenetic changes, altered neurogenesis and apoptosis, mitochondrial dysfunction, inflammation, and oxidative stress. Many available agents, such as lithium, have effects on these targets. Staging models also suggest the utility of stage-specific treatment approaches that may not only target symptom reduction, but also impede illness neuroprogression. These treatment approaches range from prevention for at-risk individuals, to early intervention strategies for prodromal and newly diagnosed individuals, complex combination therapy for rapidly recurrent illness, and palliative-type approaches for those at chronic, late stages of illness. There is hope that prompt initiation of potentially disease modifying therapies may preclude or attenuate the cognitive and structural changes seen in the later stages of bipolar disorder. The aims of this paper are to: a

  5. Verbal Memory Impairment in Patients with Subsyndromal Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Tomiki Sumiyoshi

    2017-09-01

    Full Text Available BackgroundsSeveral domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1 test the criterion-related validity and test–retest reliability of the California Verbal Learning Test (CVLT-II Japanese version, and (2 determine if type of word learning tasks (i.e., with or without a category structure affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder.MethodsThirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS, and Hopkins Verbal Memory Tests-Revised (HVLT-R. We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard or alternate forms of the CVLT-II and HVLT-R 1 month later.ResultsScores on the CVLT-II 1–5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test–retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II.ConclusionThese results suggest the CVLT-II Japanese version is able to discriminate between bipolar

  6. Verbal Memory Impairment in Patients with Subsyndromal Bipolar Disorder.

    Science.gov (United States)

    Sumiyoshi, Tomiki; Toyomaki, Atsuhito; Kawano, Naoko; Kitajima, Tomoko; Kusumi, Ichiro; Ozaki, Norio; Iwata, Nakao; Sueyoshi, Kazuki; Nakagome, Kazuyuki

    2017-01-01

    Several domains of cognitive function, including learning memory and executive function, are impaired in mood disorders. Also, the relationship between disturbances of these two cognitive domains has been suggested. In line with the recent initiative to establish a standard measure of cognitive decline in bipolar disorder, the present study was conducted to (1) test the criterion-related validity and test-retest reliability of the California Verbal Learning Test (CVLT)-II Japanese version, and (2) determine if type of word learning tasks (i.e., with or without a category structure) affects severity of verbal memory deficits in patients with subsyndromal bipolar disorder. Thirty-six patients with bipolar disorder with mild symptoms and 42 healthy volunteers participated in the study. We first compared effect sizes for memory deficits in patients among the CVLT-II, Brief Assessment of Cognition in Schizophrenia (BACS), and Hopkins Verbal Memory Tests-Revised (HVLT-R). We next evaluated the correlations between scores of the CVLT-II vs. those of the BACS and HVLT-R. Bipolar patients were re-assessed with the same (standard) or alternate forms of the CVLT-II and HVLT-R 1 month later. Scores on the CVLT-II 1-5 Free Recall and Long-delay Free Recall, as well as the HVLT-R Immediate Recall, but not the BACS List Learning were significantly lower for patients compared to control subjects. The effect sizes for cognitive decline due to the illness were comparable when measured by the CVLT-II and HVLT-R, ranging from 0.5 to 0.6. CVLT-II scores were significantly correlated with those of the HVLT-R and BACS. Test-retest reliability of the CVLT-II was acceptable, and no significant practice effect was observed when the alternate form was used. There was no consistent relationship between mood symptoms and performance on the CVLT-II. These results suggest the CVLT-II Japanese version is able to discriminate between bipolar disorder patients and healthy controls with good

  7. Nonlinear waves in bipolar complex viscous astroclouds

    Science.gov (United States)

    Karmakar, P. K.; Haloi, A.

    2017-05-01

    A theoretical evolutionary model to analyze the dynamics of strongly nonlinear waves in inhomogeneous complex astrophysical viscous clouds on the gravito-electrostatic scales of space and time is procedurally set up. It compositionally consists of warm lighter electrons and ions (Boltzmanian); and cold massive bi-polar dust grains (inertial fluids) alongside vigorous neutral dynamics in quasi-neutral hydrodynamic equilibrium. Application of the Sagdeev pseudo-potential method reduces the inter-coupled structure equations into a pair of intermixed forced Korteweg-de Vries-Burgers (f-KdVB) equations. The force-terms are self-consistently sourced by inhomogeneous gravito-electrostatic interplay. A numerical illustrative shape-analysis based on judicious astronomical parametric platform shows the electrostatic waves evolving as compressive dispersive shock-like eigen-modes. A unique transition from quasi-monotonic to non-monotonic oscillatory compressive shock-like patterns is found to exist. In contrast, the self-gravitational and effective perturbations grow purely as non-monotonic compressive oscillatory shock-like structures with no such transitory features. It is seen that the referral frame velocity acts as amplitude-reducing agent (stabilizing source) for the electrostatic fluctuations solely. A comparison in the prognostic light of various earlier satellite-based observations and in-situ measurements is presented. The paper ends up with synoptic highlights on the main implications and non-trivial applications in the interstellar space and cosmic plasma environments leading to bounded structure formation.

  8. Fabrication of graphene and ZnO nanocones hybrid structure for transparent field emission device

    Energy Technology Data Exchange (ETDEWEB)

    Zulkifli, Zurita [Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology (Japan); Faculty of Electrical Engineering, Universiti Teknologi Mara (Malaysia); Shinde, Sachin M.; Suguira, Takatoshi [Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology (Japan); Kalita, Golap, E-mail: kalita.golap@nitech.ac.jp [Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology (Japan); Center for Fostering Young and Innovative Researchers, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555 (Japan); Tanemura, Masaki [Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology (Japan)

    2015-11-30

    Graphical abstract: Fabrication of a transparent field emission device with chemical vapor deposited graphene and zinc oxide nanocones showing low turn-on field due to locally enhance electric field. - Highlights: • Demonstrated transparent field emission device with CVD graphene and ZnO nanocones. • Graphene film was coated on carbon doped ZnO nanocone prepared by ion irradiation. • Low turn-on field for the graphene/C:ZnO nanocones hybrid structure is achieved. • Graphene/C:ZnO heterostructure is promising for transparent field emission devices. - Abstract: Fabrication of a transparent and high performance electron emission device is the key challenge for suitable display applications. Here, we demonstrate fabrication of a transparent and efficient field emission device integrating large-area chemical vapor deposited graphene and carbon doped zinc oxide (C:ZnO) nanocones. The ZnO nanocones were obtained with ion irradiation process at room temperature, over which the graphene film was transferred without destroying nanocone tips. Significant enhancement in field emission properties were observed with the transferred graphene film on C:ZnO nanocones. The threshold field for hybrid and pristine C:ZnO nanocones film at current density of 1 μA/cm{sup 2} was obtained as 4.3 V/μm and 6.5 V/μm, respectively. The enhanced field emission properties with low turn-on field for the graphene/C:ZnO nanocones can be attributed to locally enhance electric field. Our finding shows that a graphene/C:ZnO hybridized structure is very promising to fabricate field emission devices without compromising with high transparency.

  9. Autoblocking dose-limiting normal structures within a radiation treatment field: 3-D computer optimization of 'unconventional' field arrangements

    International Nuclear Information System (INIS)

    Bates, Brian A.; Cullip, Timothy J.; Rosenman, Julian G.

    1995-01-01

    Purpose/Objective: To demonstrate that one can obtain a homogeneous dose distribution within a specified gross tumor volume (GTV) while severely limiting the dose to a structure surrounded by that tumor volume. We present three clinical examples below. Materials and Methods: Using planning CT scans from previously treated patients, we designed variety of radiation treatment plans in which the dose-critical normal structure was blocked, even if it meant blocking some of the tumor. To deal with the resulting dose inhomogeneities within the tumor, we introduced 3D compensation. Examples presented here include (1) blocking the spinal cord segment while treating an entire vertebral body, (2) blocking both kidneys while treating the entire peritoneal cavity, and (3) blocking one parotid gland while treating the oropharynx in its entirety along with regional nodes. A series of multiple planar and non-coplanar beam templates with automatic anatomic blocking and field shaping were designed for each scenario. Three-dimensional compensators were designed that gave the most homogeneous dose-distribution for the GTV. For each beam, rays were cast from the beam source through a 2D compensator grid and out through the tumor. The average tumor dose along each ray was then used to adjust the compensator thickness over successive iterations to achieve a uniform average dose. DVH calculations for the GTV, normal structures, and the 'auto-blocked' structure were made and used for inter-plan comparisons. Results: These optimized treatment plans successfully decreased dose to the dose-limiting structure while at the same time preserving or even improving the dose distribution to the tumor volume as compared to traditional treatment plans. Conclusion: The use of 3D compensation allows one to obtain dose distributions that are, theoretically, at least, far superior to those in common clinical use. Sensible beam templates, auto-blocking, auto-field shaping, and 3D compensators form a

  10. Bipolar cloud-to-ground lightning flash observations

    Science.gov (United States)

    Saba, Marcelo M. F.; Schumann, Carina; Warner, Tom A.; Helsdon, John H.; Schulz, Wolfgang; Orville, Richard E.

    2013-10-01

    lightning is usually defined as a lightning flash where the current waveform exhibits a polarity reversal. There are very few reported cases of cloud-to-ground (CG) bipolar flashes using only one channel in the literature. Reports on this type of bipolar flashes are not common due to the fact that in order to confirm that currents of both polarities follow the same channel to the ground, one necessarily needs video records. This study presents five clear observations of single-channel bipolar CG flashes. High-speed video and electric field measurement observations are used and analyzed. Based on the video images obtained and based on previous observations of positive CG flashes with high-speed cameras, we suggest that positive leader branches which do not participate in the initial return stroke of a positive cloud-to-ground flash later generate recoil leaders whose negative ends, upon reaching the branch point, traverse the return stroke channel path to the ground resulting in a subsequent return stroke of opposite polarity.

  11. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants

    NARCIS (Netherlands)

    Altshuler, LL; Suppes, T; Nolen, WA; Leverich, G; Keck, PE; Frye, MA; Kupka, R; McElroy, SL; Grunze, H; Kitchen, CMR; Post, R; Black, D.O.

    Objectives: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. Method: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with

  12. Brief Report: A Family Risk Study Exploring Bipolar Spectrum Problems and Cognitive Biases in Adolescent Children of Bipolar Parents

    Science.gov (United States)

    Espie, Jonathan; Jones, Steven H.; Vance, Yvonne H.; Tai, Sara J.

    2012-01-01

    Children of parents with bipolar disorder are at increased risk of bipolar spectrum diagnoses. This cross-sectional study explores cognitive factors in the prediction of vulnerability to bipolar disorder. Adolescents at high-risk (with a parent with bipolar disorder; n = 23) and age and gender matched adolescents (n = 24) were recruited. Parent…

  13. VALPROATE, BIPOLAR DISORDER AND POLYCYSTIC OVARIAN SYNDROME.

    Science.gov (United States)

    Okanović, Milana; Zivanović, Olga

    2016-01-01

    Polycystic ovarian syndrome is a syndrome of ovarian dysfunction with the principal features of hyperandrogenism and polycystic ovary morphology. A large number of studies conducted on this topic have suggested a possible role of anticonvulsants, particularly valproate, in the pathogenesis or risk factors associated with polycystic ovarian syndrome. Bipolar treatment guidelines from Canada and the United States of America recommend valproate as the first line strategy in the acute treatment of bipolar disorder. Most persons with bipolar disorder require maintenance treatment. Long-term administration of valproate in women with bipolar disorder or epilepsy is believed to result in the increased risk of hyperandrogenism, menstrual abnormalities and polycystic ovaries. Valproate may also increase the risk of infertility and other associated symptoms of polycystic ovarian syndrome. Therefore, particular caution is indicated in the use of valproate in women of reproductive age. The treatment of the female patients with bipolar disorder presents various challenges for the clinician. Every woman of reproductive age needs to know the risk and benefits of her pharmacologic treatment options. Bipolar disorder should be considered chronic disorder, whose development is largely affected by hormonal changes and reproductive cycle in women. These issues should be researched more thoroughly in order to opt for the most appropriate treatment in women with bipolar disorder.

  14. Bipolar plates for PEM fuel cells

    Science.gov (United States)

    Middelman, E.; Kout, W.; Vogelaar, B.; Lenssen, J.; de Waal, E.

    The bipolar plates are in weight and volume the major part of the PEM fuel cell stack, and are also a significant contributor to the stack costs. The bipolar plate is therefore a key component if power density has to increase and costs must come down. Three cell plate technologies are expected to reach targeted cost price levels, all having specific advantages and drawbacks. NedStack has developed a conductive composite materials and a production process for fuel cell plates (bipolar and mono-polar). The material has a high electric and thermal conductivity, and can be processed into bipolar plates by a proprietary molding process. Process cycle time has been reduced to less than 10 s, making the material and process suitable for economical mass production. Other development work to increase material efficiency resulted in thin bipolar plates with integrated cooling channels, and integrated seals, and in two-component bipolar plates. Total thickness of the bipolar plates is now less than 3 mm, and will be reduced to 2 mm in the near future. With these thin integrated plates it is possible to increase power density up to 2 kW/l and 2 kW/kg, while at the same time reducing cost by integrating other functions and less material use.

  15. Distinctions of bipolar disorder symptoms in adolescence.

    Science.gov (United States)

    Gudiene, Devika; Leskauskas, Darius; Markeviciūte, Aurelija; Klimavicius, Dalius; Adomaitiene, Virginija

    2008-01-01

    Bipolar disorder in adolescents is a serious mental illness with problematic diagnosis that adversely affects social, academic, emotional, and family functioning. The objective of this study was to analyze features of premorbid and clinical symptoms, comorbidity, and course of bipolar disorder in adolescence. Data for analysis were collected from all case histories (N=6) of 14-18-year-old patients, hospitalized with diagnosis of bipolar disorder in the Unit of Children's and Adolescents' Psychiatry, Department of Psychiatry, Hospital of Kaunas University of Medicine, during the period from 2000 to 2005. Analysis of bipolar disorder course showed that five patients previously had been diagnosed with an episode of depression. The most frequent symptoms typical to bipolar disorder were disobedience and impulsive behavior, rapid changes of mood. The most common premorbid features were frequent changes of mood, being active in communication, hyperactive behavior. Adolescence-onset bipolar disorder was frequently comorbid with emotionally instable personality disorder, borderline type. Findings of the study confirm the notion that oppositional or impulsive behavior, rapid changes of mood without any reason, dysphoric mood and euphoric mood episodes with increased energy were cardinal symptoms of bipolar disorder with mania in adolescents. Most frequent premorbid features of these patients were quite similar to attention-deficit/hyperactivity disorder making differential diagnosis problematic.

  16. Comparison of clinical and sociodemographic features of bipolar disorder patients with those of social anxiety disorder patients comorbid with bipolar disorder in Turkey

    Directory of Open Access Journals (Sweden)

    Tonguç D. Berkol

    2016-03-01

    Full Text Available Objectives: To assess the impact of social anxiety disorder (SAD comorbidity on the clinical features, illness severity, and response to mood stabilizers in bipolar disorder (BD patients. Methods: This retrospective study included bipolar patients that were treated at the Department of Psychiatry, Haseki Training and Research Hospital, Istanbul, Turkey in 2015, and who provided their informed consents for participation in this study. The study was conducted by assessing patient files retrospectively. Two hundred bipolar patients were assessed using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition axis-I (SCID-I in order to detect all possible comorbid psychiatric diagnoses. The sample was split according to the presence of SAD comorbidity and the groups were compared. Results: The SAD comorbidity was detected in 17.5% (35/200 of the BD patients. The SAD comorbid bipolar patients were more educated, had earlier onset of BD, lower number of manic episodes, and more severe episodes. There was no difference between groups in terms of total number of episodes, hospitalization, suicidality, being psychotic, treatment response to lithium and anticonvulsants. Conclusion: Social anxiety disorder comorbidity may be associated with more severe episodes and early onset of BD. However, SAD comorbidity may not be related to treatment response in bipolar patients.

  17. Screening for bipolar disorders in Spanish-speaking populations: sensitivity and specificity of the Bipolar Spectrum Diagnostic Scale-Spanish Version.

    Science.gov (United States)

    Vázquez, Gustavo Héctor; Romero, Ester; Fabregues, Fernando; Pies, Ronald; Ghaemi, Nassir; Mota-Castillo, Manuel

    2010-01-01

    Bipolar disorder is commonly misdiagnosed, perhaps more so in Latin American and Spanish-speaking populations than in the United States. The Bipolar Spectrum Diagnostic Scale (BSDS) is a 19-item screening instrument designed to assist in screening for all types of bipolar disorder. The authors investigated the sensitivity of a Spanish-language version of the BSDS in a cohort of 65 outpatients with a diagnosis of bipolar disorder, based on a semi-structured interview and Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. To determine specificity, we assessed a control group of 36 outpatients with diagnosis of unipolar major depressive disorder. The overall sensitivity of the BSDS Spanish version with bipolar disorders types I, II, and NOS was 0.70, which was slightly lower than the sensitivity in the study using the English version of the BSDS (0.76). The specificity was 0.89. When the threshold was decreased from 13 to 12, the sensitivity of the Spanish BSDS increased to 0.76 and specificity dropped to 0.81. The Spanish version of the BSDS is promising as a screening instrument in Spanish-speaking populations. Copyright 2010 Elsevier Inc. All rights reserved.

  18. Unidirectional threshold switching in Ag/Si-based electrochemical metallization cells for high-density bipolar RRAM applications

    Science.gov (United States)

    Wang, Chao; Song, Bing; Li, Qingjiang; Zeng, Zhongming

    2018-03-01

    We herein present a novel unidirectional threshold selector for cross-point bipolar RRAM array. The proposed Ag/amorphous Si based threshold selector showed excellent threshold characteristics in positive field, such as high selectivity ( 105), steep slope (type RRAM. By integrating a bipolar RRAM device with the selector, experiments showed that the undesired sneak was significantly suppressed, indicating its potentiality for high-density integrated nonvolatile memory applications.

  19. Bipolar Disorder and Early Affective Trauma.

    Science.gov (United States)

    de Codt, Aloise; Monhonval, Pauline; Bongaerts, Xavier; Belkacemi, Ikram; Tecco, Juan Martin

    2016-09-01

    Bipolar disorder is a chronic psychiatric disease with a high prevalence and is a major psychosocial and medical burden. The exact etiological pathways of bipolar disorder are not fully understood. Genetic factors are known to play an important role in the etiology of bipolar disorder. However, high rates of discordance among identical twins and a growing body of evidence that environmental factors such as early stress can influence the onset and course of psychiatric diseases underline the importance of additional etiological mechanisms of bipolar disorders. There has been little investigation about early trauma in bipolar disorder. The aim of this study was to review the literature on the association between early traumatic interactions like child neglect, mistreatment, abuse or early parental separation and the occurrence of bipolar disorder in adulthood or impact on the course of the disease. Studies investigating associations between child neglect, mistreatment, abuse or early parental separation and occurrence of bipolar disorder in adulthood or impact on the course of the disease were searched in the Pubmed database. More than 700 articles were sorted independently by two of the authors using predefined criteria. Only research articles, reviews and meta-analyses were selected for this review. 53 articles met the inclusion criteria. To date, four systematic reviews partially addressed our research question. Early trauma is more frequently found in the past of bipolar patients than in the general population. Studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a worse prognosis. Early trauma is more often found in the past of bipolar adult patients than the general population and studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a

  20. Ionizing radiations simulation on bipolar components

    International Nuclear Information System (INIS)

    Montagner, X.

    1999-01-01

    This thesis presents the ionizing radiation effects on bipolar components and more specially their behavior facing the total dose. The first part is devoted to the radiation environments with a special attention to the spatial environments and new emergent environments. The specificities of bipolar components are then presented and their behavior facing the interactions. The physical mechanisms bound to the dose rate are also discussed. The second part presents a physical analysis of degradations induced by the cumulated dosimetry on bipolar components and simulation with the ATLAS code. The third part exposes an electric empirical simulation induced by the cumulated dose in static conditions. (A.L.B.)

  1. The Large Scale Structure of the Galactic Magnetic Field and High Energy Cosmic Ray Anisotropy

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez-Muniz, Jaime [Department de Fisica de PartIculas, University de Santiago de Compostela, 15782 Santiago, SPAIN (Spain); Stanev, Todor [Bartol Research Institute, Department of Physics and Astronomy, University of Delaware, Newark, Delaware 19716 (United States)

    2006-10-15

    Measurements of the magnetic field in our Galaxy are complex and usually difficult to interpret. A spiral regular field in the disk is favored by observations, however the number of field reversals is still under debate. Measurements of the parity of the field across the Galactic plane are also very difficult due to the presence of the disk field itself. In this work we demonstrate that cosmic ray protons in the energy range 10{sup 18} to 10{sup 19}eV, if accelerated near the center of the Galaxy, are sensitive to the large scale structure of the Galactic Magnetic Field (GMF). In particular if the field is of even parity, and the spiral field is bi-symmetric (BSS), ultra high energy protons will predominantly come from the Southern Galactic hemisphere, and predominantly from the Northern Galactic hemisphere if the field is of even parity and axi-symmetric (ASS). There is no sensitivity to the BSS or ASS configurations if the field is of odd parity.

  2. Ni-based amorphous alloy-coating for bipolar plate of PEM fuel cell by electrochemical plating

    International Nuclear Information System (INIS)

    Yamaura, S; Kim, S C; Inoue, A

    2013-01-01

    In this study, the Ni-Cr-P amorphous alloy-coated bipolar plates were produced by electro-plating on the Cu base plates with a flow field. The power generation tests of a single fuel cell with those Ni-Cr-P bipolar plates were conducted at 353 K. It was found that the single fuel cell with those Ni-Cr-P bipolar plates showed excellent I-V performance as well as that with the carbon graphite bipolar plates. It was also found that the single cell with those Ni-Cr-P bipolar plates showed better I-V performance than that with the Ni-P amorphous alloy-coated bipolar plates. Furthermore, the long-time operation test was conducted for 440 h with those Ni-Cr-P bipolar plates at the constant current density of 200 mA·cm −2 . As a result, it was found that the cell voltage gradually decreased at the beginning of the measurement before 300 h and then the voltage was kept constant after 300 h.

  3. A novel scale for measuring mixed states in bipolar disorder.

    Science.gov (United States)

    Cavanagh, Jonathan; Schwannauer, Matthias; Power, Mick; Goodwin, Guy M

    2009-01-01

    Conventional descriptions of bipolar disorder tend to treat the mixed state as something of an afterthought. There is no scale that specifically measures the phenomena of the mixed state. This study aimed to test a novel scale for mixed state in a clinical and community population of bipolar patients. The scale included clinically relevant symptoms of both mania and depression in a bivariate scale. Recovered respondents were asked to recall their last manic episode. The scale allowed endorsement of one or more of the manic and depressive symptoms. Internal consistency analyses were carried out using Cronbach alpha. Factor analysis was carried out using a standard Principal Components Analysis followed by Varimax Rotation. A confirmatory factor analytic method was used to validate the scale structure in a representative clinical sample. The reliability analysis gave a Cronbach alpha value of 0.950, with a range of corrected-item-total-scale correlations from 0.546 (weight change) to 0.830 (mood). The factor analysis revealed a two-factor solution for the manic and depressed items which accounted for 61.2% of the variance in the data. Factor 1 represented physical activity, verbal activity, thought processes and mood. Factor 2 represented eating habits, weight change, passage of time and pain sensitivity. This novel scale appears to capture the key features of mixed states. The two-factor solution fits well with previous models of bipolar disorder and concurs with the view that mixed states may be more than the sum of their parts.

  4. Bad on the net, or bipolars' lives on the web: analyzing discussion web pages for individuals with bipolar affective disorder.

    Science.gov (United States)

    Latalova, Klara; Prasko, Jan; Kamaradova, Dana; Ivanova, Katerina; Jurickova, Lubica

    2014-01-01

    The main therapeutic approach in the treatment of bipolar affective disorder is the administration of drugs. The effectiveness of this approach can be increased by specific psychotherapeutic interventions. There is not much knowledge about self-help initiatives in this field. Anonymous internet communication may be beneficial, regardless of the fact that it is non-professional. It offers a chance to confide and share symptoms with other patients, to open up for persons with feelings of shame, and to obtain relevant information without having a direct contact with an expert. Qualitative analysis of web discussions used by patients with bipolar disorder in Czech language was performed. Using key words "diskuze" (discussion), "maniodeprese" (manic depression) and "bipolární porucha" (bipolar disorder), 8 discussions were found, but only 3 of them were anonymous and non-professional. Individual discussion entries were analyzed for basic categories or subcategories, and these were subsequently assessed so that their relationships could be better understood. A total of 436 entries from 3 discussion web pages were analyzed. Subsequently, six categories were identified (participant, diagnosis, relationships, communication, topic and treatment), each having 5-12 subcategories. These were analyzed in terms of relationships and patterns. Czech discussion web pages for people suffering from bipolar disorder are a lively community of users supporting each other, that may be characterized as a compact body open to newcomers. They seem to fulfill patients' needs that are not fully met by health care services. It also has a "self-cleaning" ability, effectively dealing with posts that are inappropriate, provocative, criticizing, aggressive or meaningless.

  5. Effective field study of ising model on a double perovskite structure

    Energy Technology Data Exchange (ETDEWEB)

    Ngantso, G. Dimitri; El Amraoui, Y. [LMPHE, (URAC 12), Faculté des Sciences, Université Mohammed V, Rabat (Morocco); Benyoussef, A. [LMPHE, (URAC 12), Faculté des Sciences, Université Mohammed V, Rabat (Morocco); Center of Materials and Nanomaterials, MAScIR, Rabat (Morocco); Hassan II Academy of Science and Technology, Rabat (Morocco); El Kenz, A., E-mail: elkenz@fsr.ac.ma [LMPHE, (URAC 12), Faculté des Sciences, Université Mohammed V, Rabat (Morocco)

    2017-02-01

    By using the effective field theory (EFT), the mixed spin-1/2 and spin-3/2 Ising ferrimagnetic model adapted to a double perovskite structure has been studied. The EFT calculations have been carried out from Ising Hamiltonian by taking into account first and second nearest-neighbors interactions and the crystal and external magnetic fields. Both first- and second-order phase transitions have been found in phase diagrams of interest. Depending on crystal-field values, the thermodynamic behavior of total magnetization indicated the compensation phenomenon existence. The hysteresis behaviors are studied by investigating the reduced magnetic field dependence of total magnetization and a series of hysteresis loops are shown for different reduced temperatures around the critical one. - Highlights: • Magnetic properties of double perovskite Structure have been studied. • Compensation temperature has been observed below the critical temperature. • Hysteresis behaviors have been studied.

  6. Effective field study of ising model on a double perovskite structure

    International Nuclear Information System (INIS)

    Ngantso, G. Dimitri; El Amraoui, Y.; Benyoussef, A.; El Kenz, A.

    2017-01-01

    By using the effective field theory (EFT), the mixed spin-1/2 and spin-3/2 Ising ferrimagnetic model adapted to a double perovskite structure has been studied. The EFT calculations have been carried out from Ising Hamiltonian by taking into account first and second nearest-neighbors interactions and the crystal and external magnetic fields. Both first- and second-order phase transitions have been found in phase diagrams of interest. Depending on crystal-field values, the thermodynamic behavior of total magnetization indicated the compensation phenomenon existence. The hysteresis behaviors are studied by investigating the reduced magnetic field dependence of total magnetization and a series of hysteresis loops are shown for different reduced temperatures around the critical one. - Highlights: • Magnetic properties of double perovskite Structure have been studied. • Compensation temperature has been observed below the critical temperature. • Hysteresis behaviors have been studied.

  7. Ray calibration and phase mapping for structured-light-field 3D reconstruction.

    Science.gov (United States)

    Cai, Zewei; Liu, Xiaoli; Peng, Xiang; Gao, Bruce Z

    2018-03-19

    In previous work, we presented a structured light field (SLF) method combining light field imaging with structured illumination to perform multi-view depth measurement. However, the previous work just accomplishes depth rather than 3D reconstruction. In this paper, we propose a novel active method involving ray calibration and phase mapping, to achieve SLF 3D reconstruction. We performed the ray calibration for the first time to determine each light field ray with metric spatio-angular parameters, making the SLF realize multi-view 3D reconstruction. Based on the ray parametric equation, we further derived the phase mapping in the SLF that spatial coordinates can be directly mapped from phase. A flexible calibration strategy was correspondently designed to determine mapping coefficients for each light field ray, achieving high-efficiency SLF 3D reconstruction. Experimental results demonstrated that the proposed method was suitable for high-efficiency multi-view 3D reconstruction in the SLF.

  8. Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

    Science.gov (United States)

    Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

    2011-01-01

    Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts. PMID:21668080

  9. 3D Biomimetic Magnetic Structures for Static Magnetic Field Stimulation of Osteogenesis

    Directory of Open Access Journals (Sweden)

    Irina Alexandra Paun

    2018-02-01

    Full Text Available We designed, fabricated and optimized 3D biomimetic magnetic structures that stimulate the osteogenesis in static magnetic fields. The structures were fabricated by direct laser writing via two-photon polymerization of IP-L780 photopolymer and were based on ellipsoidal, hexagonal units organized in a multilayered architecture. The magnetic activity of the structures was assured by coating with a thin layer of collagen-chitosan-hydroxyapatite-magnetic nanoparticles composite. In vitro experiments using MG-63 osteoblast-like cells for 3D structures with gradients of pore size helped us to find an optimum pore size between 20–40 µm. Starting from optimized 3D structures, we evaluated both qualitatively and quantitatively the effects of static magnetic fields of up to 250 mT on cell proliferation and differentiation, by ALP (alkaline phosphatase production, Alizarin Red and osteocalcin secretion measurements. We demonstrated that the synergic effect of 3D structure optimization and static magnetic stimulation enhances the bone regeneration by a factor greater than 2 as compared with the same structure in the absence of a magnetic field.

  10. 3D Biomimetic Magnetic Structures for Static Magnetic Field Stimulation of Osteogenesis.

    Science.gov (United States)

    Paun, Irina Alexandra; Popescu, Roxana Cristina; Calin, Bogdan Stefanita; Mustaciosu, Cosmin Catalin; Dinescu, Maria; Luculescu, Catalin Romeo

    2018-02-07

    We designed, fabricated and optimized 3D biomimetic magnetic structures that stimulate the osteogenesis in static magnetic fields. The structures were fabricated by direct laser writing via two-photon polymerization of IP-L780 photopolymer and were based on ellipsoidal, hexagonal units organized in a multilayered architecture. The magnetic activity of the structures was assured by coating with a thin layer of collagen-chitosan-hydroxyapatite-magnetic nanoparticles composite. In vitro experiments using MG-63 osteoblast-like cells for 3D structures with gradients of pore size helped us to find an optimum pore size between 20-40 µm. Starting from optimized 3D structures, we evaluated both qualitatively and quantitatively the effects of static magnetic fields of up to 250 mT on cell proliferation and differentiation, by ALP (alkaline phosphatase) production, Alizarin Red and osteocalcin secretion measurements. We demonstrated that the synergic effect of 3D structure optimization and static magnetic stimulation enhances the bone regeneration by a factor greater than 2 as compared with the same structure in the absence of a magnetic field.

  11. Infrared polarimetry of dark clouds. Pt. 1. Magnetic field structure in Heiles Cloud 2

    Energy Technology Data Exchange (ETDEWEB)

    Tamura, Motohide; Nagata, Tetsuya; Sato, Shuji; Tanaka, Masuo

    1987-01-15

    The K-band polarization of 18 stars toward Heiles Cloud 2 in the Taurus dark cloud complex has been measured to investigate the structure of the magnetic field in this cloud. The observed polarization vectors are well aligned, with a mean position angle of approx. 50/sup 0/, which is perpendicular to the direction of the elongation of the cloud. This indicates that Heiles Cloud 2 has formed by contraction along the magnetic field, resulting in the flattened shape.

  12. Phase structure of Gross-Neveu model with compactification in the presence of external magnetic field

    International Nuclear Information System (INIS)

    Zhokhov, R.N.; Kolmakov, P. B.; Zhukovsky, V.Ch.; Klimenko, K.G.

    2016-01-01

    In the paper there have been studied Gross-Neveu model in (2+1)-dimensional space-time with one compactified dimension in presence of external magnetic field at finite temperature. Magnetic field is directed along the uncompactified dimension that is along the axis of the cylinder on which the system lives. Chiral symmetry breaking and corresponding phase structure of the model is investigated in the leading order of (1/N) expansion

  13. Field control in a standing wave structure at high average beam power

    International Nuclear Information System (INIS)

    McKeown, J.; Fraser, J.S.; McMichael, G.E.

    1976-01-01

    A 100% duty factor electron beam has been accelerated through a graded-β side-coupled standing wave structure operating in π/2 mode. Three non-interacting control loops are necessary to provide the accelerating field amplitude and phase and to control structure resonance. The principal disturbances have been identified and measured over the beam current range of 0 to 20 mA. Design details are presented of control loops which regulate the accelerating field amplitude to +-0.3% and its phase to +-0.5 deg for 50% beam loading. (author)

  14. Calculation of longitudinal and transverse wake-field effects in dielectric structures

    International Nuclear Information System (INIS)

    Gai, W.

    1989-01-01

    The electro-magnetic radiation of a charged particle passing through a dielectric structure has many applications to accelerator physics. Recently a new acceleration scheme, called the dielectric wake field accelerator, has been proposed. It also can be used as a pick up system for a storage ring because of its slow wave characteristics. In order to study these effects in detail, in this paper we will calculate the wake field effects produced in a dielectric structure by a charged particle. 8 refs., 2 figs

  15. Phase structure of (φ4)3 field theory at finite temperature

    International Nuclear Information System (INIS)

    Efimov, G.V.

    1992-01-01

    Phase structure of φ 4 field theory in the space-time R 3 is investigated at arbitrary coupling constant and temperature. The critical values of the coupling constant and temperature, corresponding to the phase transitions in the system, are calculated by the canonical transformation method within formalism of thermo field dynamics. The Hamiltonians describing the system in each phase are obtained straightforwardly. Comparison with the two-dimensional case shows a crucial influence of higher order renormalization on the phase structure of the model. 13 refs.; 5 figs

  16. Relationship among visual field, blood flow, and neural structure measurements in glaucoma.

    Science.gov (United States)

    Hwang, John C; Konduru, Ranjith; Zhang, Xinbo; Tan, Ou; Francis, Brian A; Varma, Rohit; Sehi, Mitra; Greenfield, David S; Sadda, Srinivas R; Huang, David

    2012-05-17

    To determine the relationship among visual field, neural structural, and blood flow measurements in glaucoma. Case-control study. Forty-seven eyes of 42 patients with perimetric glaucoma were age-matched with 27 normal eyes of 27 patients. All patients underwent Doppler Fourier-domain optical coherence tomography to measure retinal blood flow and standard glaucoma evaluation with visual field testing and quantitative structural imaging. Linear regression analysis was performed to analyze the relationship among visual field, blood flow, and structure, after all variables were converted to logarithmic decibel scale. Retinal blood flow was reduced in glaucoma eyes compared to normal eyes (P flow and structural loss of rim area and retinal nerve fiber layer (RNFL). There was no correlation or paradoxical correlation between blood flow and structure. Multivariate regression analysis revealed that reduced blood flow and structural loss are independent predictors of visual field loss. Each dB decrease in blood flow was associated with at least 1.62 dB loss in mean deviation (P ≤ 0.001), whereas each dB decrease in rim area and RNFL was associated with 1.15 dB and 2.56 dB loss in mean deviation, respectively (P ≤ 0.03). There is a close link between reduced retinal blood flow and visual field loss in glaucoma that is largely independent of structural loss. Further studies are needed to elucidate the causes of the vascular dysfunction and potential avenues for therapeutic intervention. Blood flow measurement may be useful as an independent assessment of glaucoma severity.

  17. Three-dimensional imaging of vortex structure in a ferroelectric nanoparticle driven by an electric field.

    Science.gov (United States)

    Karpov, D; Liu, Z; Rolo, T Dos Santos; Harder, R; Balachandran, P V; Xue, D; Lookman, T; Fohtung, E

    2017-08-17

    Topological defects of spontaneous polarization are extensively studied as templates for unique physical phenomena and in the design of reconfigurable electronic devices. Experimental investigations of the complex topologies of polarization have been limited to surface phenomena, which has restricted the probing of the dynamic volumetric domain morphology in operando. Here, we utilize Bragg coherent diffractive imaging of a single BaTiO 3 nanoparticle in a composite polymer/ferroelectric capacitor to study the behavior of a three-dimensional vortex formed due to competing interactions involving ferroelectric domains. Our investigation of the structural phase transitions under the influence of an external electric field shows a mobile vortex core exhibiting a reversible hysteretic transformation path. We also study the toroidal moment of the vortex under the action of the field. Our results open avenues for the study of the structure and evolution of polar vortices and other topological structures in operando in functional materials under cross field configurations.Imaging of topological states of matter such as vortex configurations has generally been limited to 2D surface effects. Here Karpov et al. study the volumetric structure and dynamics of a vortex core mediated by electric-field induced structural phase transition in a ferroelectric BaTiO 3 nanoparticle.

  18. Differences in clinical presentation between bipolar I and II disorders in the early stages of bipolar disorder: A naturalistic study.

    Science.gov (United States)

    Vinberg, Maj; Mikkelsen, Rie Lambaek; Kirkegaard, Thomas; Christensen, Ellen Margrethe; Kessing, Lars Vedel

    2017-01-15

    In a naturalistic clinical study of patients in the early stages of bipolar disorders the aim was to assess differences between patients with bipolar I (BD I) and bipolar II (BD II) disorders on clinical characteristics including affective symptoms, subjective cognitive complaints, functional level, the presence of comorbid personality disorders and coping strategies. Diagnoses were confirmed using the Structured Clinical Interview for DSM-IV Disorders. Clinical symptoms were rated with the Young Mania Rating Scale and the Hamilton Depression Rating Scale, and functional status using the Functional Assessment Short Test. Cognitive complaints were assessed using the Massachusetts General Hospital Cognitive and Physical Functioning Questionnaire, the presence of comorbid personality disorders using the Standardized Assessment of Personality - Abbreviated Scale and coping style using the Coping Inventory for Stressful Situations. In total, 344 patients were included (BD I (n=163) and BD II (n=181). Patients with BD II presented with significantly more depressive symptoms, more cognitive complaints, lower overall functioning, and a higher prevalence of comorbid personality disorders. Finally, they exhibited a trend towards using less adaptive coping styles. It cannot be omitted that some patients may have progressed from BD II to BD I. Most measures were based on patient self report. Overall, BD II was associated with a higher disease burden. Clinically, it is important to differentiate BD II from BD I and research wise, there is a need for tailoring and testing specific interventions towards BD II. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. A diagnosis of bipolar spectrum disorder predicts diagnostic conversion from unipolar depression to bipolar disorder: a 5-year retrospective study.

    Science.gov (United States)

    Woo, Young Sup; Shim, In Hee; Wang, Hee-Ryung; Song, Hoo Rim; Jun, Tae-Youn; Bahk, Won-Myong

    2015-03-15

    The major aims of this study were to identify factors that may predict the diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BP) and to evaluate the predictive performance of the bipolar spectrum disorder (BPSD) diagnostic criteria. The medical records of 250 patients with a diagnosis of MDD for at least 5 years were retrospectively reviewed for this study. The diagnostic conversion from MDD to BP was observed in 18.4% of 250 MDD patients, and the diagnostic criteria for BPSD predicted this conversion with high sensitivity (0.870) and specificity (0.917). A family history of BP, antidepressant-induced mania/hypomania, brief major depressive episodes, early age of onset, antidepressant wear-off, and antidepressant resistance were also independent predictors of this conversion. This study was conducted using a retrospective design and did not include structured diagnostic interviews. The diagnostic criteria for BPSD were highly predictive of the conversion from MDD to BP, and conversion was associated with several clinical features of BPSD. Thus, the BPSD diagnostic criteria may be useful for the prediction of bipolar diathesis in MDD patients. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Effects of a longitudinal magnetic field on current pulses and fast ionization-wave structure

    International Nuclear Information System (INIS)

    Asinovskii, E.I.; Lagar'kov, A.N.; Markovets, V.V.; Rutkevich, I.M.; Ul'yanov, A.M.; Filyugin, I.V.

    1988-01-01

    A longitudinal magnetic field affects the fast ionization-wave structure in a discharge tube surrounded by a metal screen. The field does not alter the wave speed, but the current amplitude is increased. This is explained from a theory for fast-wave propagation in a cylindrical guide containing an axial field. Numerical solutions have been obtained for the stationary nonlinear waves, which are compared with measurements. A theoretical study has been made on the ionization-wave features for large values of the Hall parameter