WorldWideScience

Sample records for biosynthesis app processing

  1. APP processing in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Zhang Yun-wu

    2011-01-01

    Full Text Available Abstract An important pathological feature of Alzheimer's disease (AD is the presence of extracellular senile plaques in the brain. Senile plaques are composed of aggregations of small peptides called β-amyloid (Aβ. Multiple lines of evidence demonstrate that overproduction/aggregation of Aβ in the brain is a primary cause of AD and inhibition of Aβ generation has become a hot topic in AD research. Aβ is generated from β-amyloid precursor protein (APP through sequential cleavages first by β-secretase and then by γ-secretase complex. Alternatively, APP can be cleaved by α-secretase within the Aβ domain to release soluble APPα and preclude Aβ generation. Cleavage of APP by caspases may also contribute to AD pathologies. Therefore, understanding the metabolism/processing of APP is crucial for AD therapeutics. Here we review current knowledge of APP processing regulation as well as the patho/physiological functions of APP and its metabolites.

  2. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

    Directory of Open Access Journals (Sweden)

    Martin Steuble

    2012-06-01

    Endocytosis of amyloid-β precursor protein (APP is thought to represent the major source of substrate for the production of the amyloidogenic Aβ peptide by the β-secretase BACE1. The irreversible nature of proteolytic cleavage implies the existence of an efficient replenishment route for APP from its sites of synthesis to the cell surface. We recently found that APP exits the trans-Golgi network in intimate association with calsyntenin-1, a transmembrane cargo-docking protein for Kinesin-1-mediated vesicular transport. Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, immunocytochemistry, live-imaging, and RNAi. We found that APP is co-transported with calsyntenin-1 along axons to early endosomes in the central region of growth cones in carriers that exclude the α-secretase ADAM10. Intriguingly, calsyntenin-1/APP organelles contained BACE1, suggesting premature cleavage of APP along its anterograde path. However, we found that APP contained in calsyntenin-1/APP organelles was stable. We further analyzed vesicular trafficking of APP in cultured hippocampal neurons, in which calsyntenin-1 was reduced by RNAi. We found a markedly increased co-localization of APP and ADAM10 in axons and growth cones, along with increased proteolytic processing of APP and Aβ secretion in these neurons. This suggested that the reduced capacity for calsyntenin-1-dependent APP transport resulted in mis-sorting of APP into additional axonal carriers and, therefore, the premature encounter of unprotected APP with its ectodomain proteases. In combination, our results characterize calsyntenin-1/APP organelles as carriers for sheltered anterograde axonal transport of APP.

  3. The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.

    Science.gov (United States)

    Sun, Miao; Asghar, Suwaiba Z; Zhang, Huaye

    2016-09-01

    The processing of amyloid precursor protein (APP) into β-amyloid peptide (Aβ) is a key step in the pathogenesis of Alzheimer's disease (AD), and trafficking dysregulations of APP and its secretases contribute significantly to altered APP processing. Here we show that the cell polarity protein Par3 plays an important role in APP processing and trafficking. We found that the expression of full length Par3 is significantly decreased in AD patients. Overexpression of Par3 promotes non-amyloidogenic APP processing, while depletion of Par3 induces intracellular accumulation of Aβ. We further show that Par3 functions by regulating APP trafficking. Loss of Par3 decreases surface expression of APP by targeting APP to the late endosome/lysosome pathway. Finally, we show that the effects of Par3 are mediated through the endocytic adaptor protein Numb, and Par3 functions by interfering with the interaction between Numb and APP. Together, our studies show a novel role for Par3 in regulating APP processing and trafficking.

  4. mHealth Quality: A Process to Seal the Qualified Mobile Health Apps.

    Science.gov (United States)

    Yasini, Mobin; Beranger, Jérôme; Desmarais, Pierre; Perez, Lucas; Marchand, Guillaume

    2016-01-01

    A large number of mobile health applications (apps) are currently available with a variety of functionalities. The user ratings in the app stores seem not to be reliable to determine the quality of the apps. The traditional methods of evaluation are not suitable for fast paced nature of mobile technology. In this study, we propose a collaborative multidimensional scale to assess the quality of mHealth apps. During our process, the app quality is assessed in various aspects including medical reliability, legal consistency, ethical consistency, usability aspects, personal data privacy and IT security. A hypothetico-deductive approach was used in various working groups to define the audit criteria based on the various use cases that an app could provide. These criteria were then implemented into a web based self-administered questionnaires and the generation of automatic reports were considered. This method is on the one hand specific to each app because it allows to assess each health app according to its offered functionalities. On the other hand, this method is automatic, transferable to all apps and adapted to the dynamic nature of mobile technology.

  5. Role of human GKN1 on APP processing in gastric cancer.

    Science.gov (United States)

    Di Stadio, Chiara Stella; Altieri, Filomena; Minopoli, Giuseppina; Miselli, Giuseppina; Rippa, Emilia; Arcari, Paolo

    2017-04-01

    Gastrokine 1 (GKN1) is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in gastric cancer. GKN1 belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. We previously demonstrated that a recombinant human GKN1 protein was able to interact with the amyloid precursor protein (APP) and was endowed with an anti-amyloidogenic property because it inhibited polymerization of the Aβ(1-40) peptide released from APP upon its partial hydrolysis. Here, we report that GKN1 can act as a physiological suppressor of Aβ production in gastric cancer cells. GKN1 blocked the access of γ-secretase to APP, thereby facilitating the cleavage of APP by α- and β-secretases. GKN1 directly interacted with APP C-terminal fragments, C83 and C99. In addition, it did not affect γ-secretase activity in gastric cancer cells because it did not alter Notch1 processing. GKN1-mediated inhibition of APP processing might represent a new approach for the prevention and therapy of Alzheimer's disease (AD).

  6. Implementing Project SIED: Special Education Teachers' Perceptions of a Simplified Technology Decision-Making Process for App Identification and Evaluation

    Science.gov (United States)

    Schmidt, Matthew M.; Lin, Meng-Fen Grace; Paek, Seungoh; MacSuga-Gage, Ashley; Gage, Nicholas A.

    2017-01-01

    The worldwide explosion in popularity of mobile devices has created a dramatic increase in mobile software (apps) that are quick and easy to find and install, cheap, disposable, and usually single purpose. Hence, teachers need an equally streamlined and simplified decision-making process to help them identify educational apps--an approach that…

  7. App Inventor

    CERN Document Server

    Wolber, David; Spertus, Ellen; Looney, Liz

    2011-01-01

    Yes, you can create your own apps for Android phones-and it's easy to do. This extraordinary book introduces App Inventor for Android, a powerful visual tool that lets anyone build apps for Android-based devices. Learn the basics of App Inventor with step-by-step instructions for more than a dozen fun projects, such as creating location-aware apps, data storage, and apps that include decision-making logic. The second half of the book features an Inventor's manual to help you understand the fundamentals of app building and computer science. App Inventor makes an excellent textbook for beginne

  8. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA Proteins Alter Amyloid-β Precursor Protein (APP Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1.

    Directory of Open Access Journals (Sweden)

    Bjoern von Einem

    Full Text Available Proteolytic processing of amyloid-β precursor protein (APP by beta-site APP cleaving enzyme 1 (BACE1 is the initial step in the production of amyloid beta (Aβ, which accumulates in senile plaques in Alzheimer's disease (AD. Essential for this cleavage is the transport and sorting of both proteins through endosomal/Golgi compartments. Golgi-localized γ-ear-containing ARF-binding (GGA proteins have striking cargo-sorting functions in these pathways. Recently, GGA1 and GGA3 were shown to interact with BACE1, to be expressed in neurons, and to be decreased in AD brain, whereas little is known about GGA2. Since GGA1 impacts Aβ generation by confining APP to the Golgi and perinuclear compartments, we tested whether all GGAs modulate BACE1 and APP transport and processing. We observed decreased levels of secreted APP alpha (sAPPα, sAPPβ, and Aβ upon GGA overexpression, which could be reverted by knockdown. GGA-BACE1 co-immunoprecipitation was impaired upon GGA-GAE but not VHS domain deletion. Autoinhibition of the GGA1-VHS domain was irrelevant for BACE1 interaction. Our data suggest that all three GGAs affect APP processing via the GGA-GAE domain.

  9. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.

    Science.gov (United States)

    Kurkinen, Kaisa M A; Marttinen, Mikael; Turner, Laura; Natunen, Teemu; Mäkinen, Petra; Haapalinna, Fanni; Sarajärvi, Timo; Gabbouj, Sami; Kurki, Mitja; Paananen, Jussi; Koivisto, Anne M; Rauramaa, Tuomas; Leinonen, Ville; Tanila, Heikki; Soininen, Hilkka; Lucas, Fiona R; Haapasalo, Annakaisa; Hiltunen, Mikko

    2016-06-01

    Dysfunction and loss of synapses are early pathogenic events in Alzheimer's disease. A central step in the generation of toxic amyloid-β (Aβ) peptides is the cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme (BACE1). Here, we have elucidated whether downregulation of septin (SEPT) protein family members, which are implicated in synaptic plasticity and vesicular trafficking, affects APP processing and Aβ generation. SEPT8 was found to reduce soluble APPβ and Aβ levels in neuronal cells through a post-translational mechanism leading to decreased levels of BACE1 protein. In the human temporal cortex, we identified alterations in the expression of specific SEPT8 transcript variants in a manner that correlated with Alzheimer's-disease-related neurofibrillary pathology. These changes were associated with altered β-secretase activity. We also discovered that the overexpression of a specific Alzheimer's-disease-associated SEPT8 transcript variant increased the levels of BACE1 and Aβ peptides in neuronal cells. These changes were related to an increased half-life of BACE1 and the localization of BACE1 in recycling endosomes. These data suggest that SEPT8 modulates β-amyloidogenic processing of APP through a mechanism affecting the intracellular sorting and accumulation of BACE1.

  10. Streptomycetes biosynthesis processes in the presence of vegetable oils

    Directory of Open Access Journals (Sweden)

    I. V. Zhernosekova

    2012-06-01

    Full Text Available The rise of biosynthesis activity of the strain Streptomyces recifensis var. lyticus 2Р-15 induced by vegetable oil was established. When cultivating the streptomycetes in the mixed medium (glucose and sunflower oil the maximum biomass accumulation and staphylolytic enzymes’ activity of the strain 2P-15 increased by 19 and 20 % respectively in comparison with the streptomycetes grown in the medium of glucose and olive oil. The concentration of exogenic protein was also 9 times more for glucose and sunflower oil substrate. Monosubstrate of sunflower or olive oil didn’t increase the biosynthetic activity of the strain. However, the maximal indices were higher for sunflower oil than for olive one.

  11. Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside.

    Science.gov (United States)

    Cai, Zheng-Xu; Guo, Hui-Shu; Wang, Che; Wei, Min; Cheng, Cheng; Yang, Zhao-Fei; Chen, Yin-Wang; Le, Wei-Dong; Li, Song

    2016-01-01

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is thought to be caused in part by the age-related accumulation of amyloid-β (Aβ) in the brain. Recent findings have revealed that nitric oxide (NO) modulates the processing of amyloid-β precursor protein (APP) and alters Aβ production; however, the previously presented data are contradictory and the underlying molecular mechanisms are still incomplete. Here, using human SH-SY5Y neuroblastoma cells stably transfected with wild-type APPwt695, we found that NO, derived from NO donor sodium nitroprusside (SNP), bi-directionally modulates APP processing in vitro. The data from ELISA and Western blot (WB) tests indicated that SNP at lower concentrations (0.01 and 0.1 μM) inhibits BACE1 expression, thus consequently suppresses APP β-cleavage and decreases Aβ production. In contrast, SNP at higher concentrations (10 and 20 μM) biases the APP processing toward the amyloidogenic pathway as evidenced by an increased BACE1 but a decreased ADAM10 expression, together with an elevated Aβ secretion. This bi-directional modulating activity of SNP on APP processing was completely blocked by specific NO scavenger c-PTIO, indicating NO-dependent mechanisms. Moreover, the anti-amyloidogenic activity of SNP is sGC/cGMP/PKG-dependent as evidenced by its reversal by sGC/PKG inhibitions, whereas the amyloidogenic activity of SNP is peroxynitrite-related and can be reversed by peroxynitrite scavenger uric acid. In summary, these present findings predict a double-edged role of NO in APP processing in vitro. Low (physiological) levels of NO inhibit the amyloidogenic processing of APP, whereas extra-high (pathological) concentrations of NO favor the amyloidogenic pathway of APP processing. This preliminary study may provide further evidence to clarify the molecular roles of NO and NO-related signaling in AD and supply potential molecular targets for AD treatment.

  12. Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease.

    Science.gov (United States)

    Guo, Chuang; Wang, Tao; Zheng, Wei; Shan, Zhong-Yan; Teng, Wei-Ping; Wang, Zhan-You

    2013-02-01

    Increasing evidence indicates that a disturbance of normal iron homeostasis and an amyloid-β (Aβ)-iron interaction may contribute to the pathology of Alzheimer's disease (AD), whereas iron chelation could be an effective therapeutic intervention. In the present study, transgenic mice expressing amyloid precursor protein (APP) and presenilin 1 and watered with high-dose iron served as a model of AD. We evaluated the effects of intranasal administration of the high-affinity iron chelator deferoxamine (DFO) on Aβ neuropathology and spatial learning and memory deficits created in this AD model. The effects of Fe, DFO, and combined treatments were also evaluated in vitro using SHSY-5Y cells overexpressing the human APP Swedish mutation. In vivo, no significant differences in the brain concentrations of iron, copper, or zinc were found among the treatment groups. We found that high-dose iron (deionized water containing 10 mg/mL FeCl(3)) administered to transgenic mice increased protein expression and phosphorylation of APP695, enhanced amyloidogenic APP cleavage and Aβ deposition, and impaired spatial learning and memory. Chelation of iron via intranasal administration of DFO (200 mg/kg once every other day for 90 days) inhibited iron-induced amyloidogenic APP processing and reversed behavioral alterations. DFO treatment reduced the expression and phosphorylation of APP protein by shifting the processing of APP to the nonamyloidogenic pathway, and the reduction was accompanied by attenuating the Aβ burden, and then significantly promoted memory retention in APP/PS1 mice. The effects of DFO on iron-induced amyloidogenic APP cleavage were further confirmed in vitro. Collectively, the present data suggest that intranasal DFO treatment may be useful in AD, and amelioration of iron homeostasis is a potential strategy for prevention and treatment of this disease.

  13. Photo Apps -

    Data.gov (United States)

    Department of Transportation — Images of various facilities used as a tool to eliminate travel time and for immediate access to concerned areas. App thumbnails images 4 per row and allows the user...

  14. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing

    Science.gov (United States)

    Yamaguchi, Tokiaki; Yamauchi, Yoshio; Furukawa, Keiko; Ohmi, Yuhsuke; Ohkawa, Yuki; Zhang, Qing; Okajima, Tetsuya; Furukawa, Koichi

    2016-01-01

    Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by the extracellular accumulation of amyloid β (Aβ) peptides, which are produced by proteolytic cleavages of amyloid precursor protein (APP). Gangliosides are involved in AD pathophysiology including Aβ deposition and APP processing, yet the detailed mechanisms are not fully understood. Here we examined how changes in the carbohydrate moiety of gangliosides alter APP processing in human melanoma cells, neuroectoderm-derived cells. We showed that forced expression of GD2, GM2 or GM1 (by introducing B4GALNT1 cDNA into cells not expressing this glycosyltransferase) results in increases of α- and β-site cleavages of APP with a prominent increase in β-cleavage. We also showed that β-site APP cleaving enzyme 1 (BACE1) protein is highly protected from the degradation in cells expressing these gangliosides, thereby increasing the expression of this protein. Unexpectedly, adding gangliosides exogenously altered neither BACE1 levels nor β-site cleavage. The stabilisation of BACE1 protein led to the increase of this protein in lipid rafts, where BACE1 processes APP. Based on the current results, we propose a hitherto undisclosed link between ganglioside expression and AD; the expression of B4GALNT1 positively regulates the β-site cleavage by mainly inhibiting the lysosomal degradation of BACE1 protein. PMID:27687691

  15. The Role of Gay Identity Confusion and Outness in Sex-Seeking on Mobile Dating Apps Among Men Who Have Sex With Men: A Conditional Process Analysis.

    Science.gov (United States)

    Chan, Lik Sam

    2017-01-01

    Mobile dating apps are now a popular platform for men who have sex with men (MSM) to connect with others. Based on the uses and gratifications (U&G) theory, this study explores the relationship between sex-seeking and the number of casual sex partners met through MSM-based mobile dating apps (Grindr, Jack'd, and SCRUFF). The conditional process analysis (N = 401) shows that this relationship was significant and was mediated by the intensity of app use. That is, sex-seeking indirectly affected the number of casual sex partners through the intensity of app use. Furthermore, gay identity confusion and outness to the world moderated this indirect effect: it was stronger when the user was either more confused about his sexuality or was less out to the world. This research introduces an alternative way to incorporate psychographics variables into the U&G framework.

  16. Natures balancing act: examining biosynthesis de novo, recycling and processing damaged vitamin B metabolites.

    Science.gov (United States)

    Colinas, Maite; Fitzpatrick, Teresa B

    2015-06-01

    Plants use B vitamin compounds as cofactors for metabolism. Biosynthesis de novo of these metabolites in plants is almost fully elucidated. However, salvaging of precursors as well as cofactor derivatives is only being unraveled. Furthermore, processing of these compounds when damaged by cellular activities to prevent deleterious effects on metabolism is emerging. Recent investigations indicate that the role of B vitamins goes beyond metabolism and are being linked with epigenetic traits, specific developmental cues, the circadian clock, as well as abiotic and biotic stress responses. More in depth investigations on the regulation of the provision of these compounds through biosynthesis de novo, salvage and transport is suggesting that plants may share the cost of this load by division of labor.

  17. Distribution of colored carotenoids between light-harvesting complexes in the process of recovering carotenoid biosynthesis in Ectothiorhodospira haloalkaliphila cells.

    Science.gov (United States)

    Ashikhmin, Aleksandr; Makhneva, Zoya; Bolshakov, Maksim; Moskalenko, Andrey

    2014-12-01

    The processes of recovering colored-carotenoid (Car) biosynthesis in Car-less cells of the purple sulfur bacterium Ectothiorhodospira haloalkaliphila grown with diphenylamine (DPA-cells) have been studied. It has been found that (1) the rate of recovering colored-Car biosynthesis in the lag-phase is far ahead of the growth rate of the cells themselves; (2) several Cars (ζ-carotene, neurosporene etc.) act as intermediates in Car biosynthesis; (3) because filling the "empty" Car pockets in the LH1-RC complexes is faster than in LH2, available spirilloxanthin is preferentially incorporated into the nascent LH1-RC core particles; (4) as a consequence of the resulting lack of spirilloxanthin availability, the biosynthetic intermediates (anhydrorhodovibrin, rhodopin and lycopene) fill the empty nascent LH2 Car pockets. In the present report, we further discuss the process of colored Car incorporation into LH complexes during the recovery of Car biosynthesis in the DPA-cells of Ect.haloalkaliphila.

  18. App Savvy Turning Ideas into iPad and iPhone Apps Customers Really Want

    CERN Document Server

    Yarmosh, Ken

    2010-01-01

    How can you make your iPad or iPhone app stand out in the highly competitive App Store? While many books simply explore the technical aspects of iPad and iPhone app design and development, App Savvy also focuses on the business, product, and marketing elements critical to pursuing, completing, and selling your app -- the ingredients for turning a great idea into a genuinely successful product. Whether you're a designer, developer, entrepreneur, or just someone with a unique idea, App Savvy explains every step in the process, with guidelines for planning a solid concept, engaging customers ea

  19. Android app development for dummies

    CERN Document Server

    Burton, Michael

    2015-01-01

    The updated edition of the bestselling guide to Android app development If you have ambitions to build an Android app, this hands-on guide gives you everything you need to dig into the development process and turn your great idea into a reality! In this new edition of Android App Development For Dummies, you'll find easy-to-follow access to the latest programming techniques that take advantage of the new features of the Android operating system. Plus, two programs are provided: a simple program to get you started and an intermediate program that uses more advanced aspects of the Android plat

  20. Biosynthesis of intestinal microvillar proteins. Processing of aminopeptidase N by microsomal membranes

    DEFF Research Database (Denmark)

    Danielsen, E M; Norén, Ove; Sjöström, H

    1983-01-01

    The biosynthesis of small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in a cell-free translation system derived from rabbit reticulocytes. When dog pancreatic microsomal fractions were present during translation, most of the aminopeptidase N synthesized was found in a membrane-bound rat......The biosynthesis of small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in a cell-free translation system derived from rabbit reticulocytes. When dog pancreatic microsomal fractions were present during translation, most of the aminopeptidase N synthesized was found in a membrane......-bound rather than a soluble form, indicating that synthesis of the enzyme takes place on ribosomes attached to the rough endoplasmic reticulum. The microsomal fractions process the Mr-115 000 polypeptide, which is the primary translation product of aminopeptidase N, to a polypeptide of Mr 140 000...... that microsomal fractions should be added before about 25% of the polypeptide was synthesized to ensure processing to the high-mannose glycosylated form. This suggests that the signal sequence is situated in the N-terminal part of the aminopeptidase N. The size of the cell-free translation product in the absence...

  1. Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.

    Science.gov (United States)

    Devi, L; Ohno, M

    2015-10-29

    β-Site APP-cleaving enzyme 1 (BACE1) initiates the generation of amyloid-β (Aβ), thus representing a prime therapeutic target for Alzheimer's disease (AD). Previous work including ours has used BACE1 haploinsufficiency (BACE1(+/-); i.e., 50% reduction) as a therapeutic relevant model to evaluate the efficacy of partial β-secretase inhibition. However, it is unclear whether the extent of Aβ reductions in amyloid precursor protein (APP) transgenic mice with BACE1(+/-) gene ablation may vary with sex or disease progression. Here, we compared the impacts of BACE1 haploinsufficiency on Aβ concentrations and APP processing in 5XFAD Alzheimer mice (1) between males and females and (2) between different stages with moderate and robust Aβ accumulation. First, male and female 5XFAD mice at 6-7 months of age showed equivalent levels of Aβ, BACE1, full-length APP and its metabolites. BACE1 haploinsufficiency significantly lowered soluble Aβ oligomers, total Aβ42 levels and plaque burden in 5XFAD mouse brains irrespective of sex. Furthermore, there was no sex difference in reductions of β-cleavage products of APP (C99 and sAPPβ) found in BACE1(+/-)·5XFAD mice relative to BACE1(+/+)·5XFAD controls. Meanwhile, APP and sAPPα levels in BACE1(+/-)·5XFAD mice were higher than those of 5XFAD controls regardless of sex. Based on these observations, we next combined male and female data to examine the effects of BACE1 haploinsufficiency in 5XFAD mice at 12-14 months of age, as compared with those in 6-7-month-old 5XFAD mice. Oligomeric Aβ and C99 levels were dramatically elevated in older 5XFAD mice. Although the β-metabolites of APP were significantly reduced by BACE1 haploinsufficiency in both age groups, high levels of these toxic amyloidogenic fragments remained in 12-14-month-old BACE1(+/-)·5XFAD mice. The present findings are consistent with our previous behavioral data showing that BACE1 haploinsufficiency rescues memory deficits in 5XFAD mice irrespective of

  2. Apps Developed by Academics

    Science.gov (United States)

    Shing, Sophia; Yuan, Benjamin

    2016-01-01

    In the days of the digital Wild West, developers from all backgrounds have joined in the gold rush trying to profit from the almost unbridled spending of well-to-do parents on educational products. In 2016, the Apple App Store had over 80,000 educational apps. The proliferation of educational apps has happened at a furious pace and more apps are…

  3. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones

    Directory of Open Access Journals (Sweden)

    Azhar Salman

    2010-06-01

    Full Text Available Abstract Steroid hormones regulate diverse physiological functions such as reproduction, blood salt balance, maintenance of secondary sexual characteristics, response to stress, neuronal function and various metabolic processes. They are synthesized from cholesterol mainly in the adrenal gland and gonads in response to tissue-specific tropic hormones. These steroidogenic tissues are unique in that they require cholesterol not only for membrane biogenesis, maintenance of membrane fluidity and cell signaling, but also as the starting material for the biosynthesis of steroid hormones. It is not surprising, then, that cells of steroidogenic tissues have evolved with multiple pathways to assure the constant supply of cholesterol needed to maintain optimum steroid synthesis. The cholesterol utilized for steroidogenesis is derived from a combination of sources: 1 de novo synthesis in the endoplasmic reticulum (ER; 2 the mobilization of cholesteryl esters (CEs stored in lipid droplets through cholesteryl ester hydrolase; 3 plasma lipoprotein-derived CEs obtained by either LDL receptor-mediated endocytic and/or SR-BI-mediated selective uptake; and 4 in some cultured cell systems from plasma membrane-associated free cholesterol. Here, we focus on recent insights into the molecules and cellular processes that mediate the uptake of plasma lipoprotein-derived cholesterol, events connected with the intracellular cholesterol processing and the role of crucial proteins that mediate cholesterol transport to mitochondria for its utilization for steroid hormone production. In particular, we discuss the structure and function of SR-BI, the importance of the selective cholesterol transport pathway in providing cholesterol substrate for steroid biosynthesis and the role of two key proteins, StAR and PBR/TSO in facilitating cholesterol delivery to inner mitochondrial membrane sites, where P450scc (CYP11A is localized and where the conversion of cholesterol to

  4. Best Android Apps

    CERN Document Server

    Hendrickson, Mike

    2010-01-01

    You can choose from thousands of apps to make your Android device do just about anything you can think of -- and probably a few things you'd never imagine. There are so many Android apps available, in fact, that it's been difficult to find the best of the bunch -- until now. Best Android Apps leads you beyond the titles in Android Market's "Top Paid" and "Top Free" bins to showcase apps that will truly delight, empower, and entertain you. The authors have tested and handpicked more than 200 apps and games, each listed with a description and details highlighting the app's valuable tips and sp

  5. Design of Trigonometry Apps for Vocational Education

    DEFF Research Database (Denmark)

    Pedersen, Jens Bjarke; Andersen, Steffen; Majgaard, Gunver

    2012-01-01

    How can smartphones apps enrich the learning of mathematicsin vocational education? This article examines how mathematics teaching can be enriched by apps using smartphone sensors such as gyroscope, compass, camera, and touch screen in a aming context. An iterative and participatory design proces...... talk about our experience in implementing our design process and subsequently summarize the pros and cons of the application and the smartphone platform and how the app developed contributes to vocational mathematics teaching....

  6. Storybook app creation demystified a cast study

    CERN Document Server

    Friedlander, Amy

    2013-01-01

    This case study explains how Wasabi Productions created its first app, Lazy Larry Lizard, and provides insight into the development of soon-to-be-released app, Gorilla Band. Inside, you will find notes on how storybook apps are produced from start to finish, including costs, production process, people, technology, pricing, release cycle, marketing and more. You will also find insights on technology, storyboard development and pricing.

  7. Expert Involvement Predicts mHealth App Downloads: Multivariate Regression Analysis of Urology Apps

    Science.gov (United States)

    Osório, Luís; Cavadas, Vitor; Fraga, Avelino; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Castelo-Branco, Miguel; Roobol, Monique J

    2016-01-01

    Background Urological mobile medical (mHealth) apps are gaining popularity with both clinicians and patients. mHealth is a rapidly evolving and heterogeneous field, with some urology apps being downloaded over 10,000 times and others not at all. The factors that contribute to medical app downloads have yet to be identified, including the hypothetical influence of expert involvement in app development. Objective The objective of our study was to identify predictors of the number of urology app downloads. Methods We reviewed urology apps available in the Google Play Store and collected publicly available data. Multivariate ordinal logistic regression evaluated the effect of publicly available app variables on the number of apps being downloaded. Results Of 129 urology apps eligible for study, only 2 (1.6%) had >10,000 downloads, with half having ≤100 downloads and 4 (3.1%) having none at all. Apps developed with expert urologist involvement (P=.003), optional in-app purchases (P=.01), higher user rating (P<.001), and more user reviews (P<.001) were more likely to be installed. App cost was inversely related to the number of downloads (P<.001). Only data from the Google Play Store and the developers’ websites, but not other platforms, were publicly available for analysis, and the level and nature of expert involvement was not documented. Conclusions The explicit participation of urologists in app development is likely to enhance its chances to have a higher number of downloads. This finding should help in the design of better apps and further promote urologist involvement in mHealth. Official certification processes are required to ensure app quality and user safety. PMID:27421338

  8. Google Apps zijn leuk

    NARCIS (Netherlands)

    den Hollander, Franciscus

    2014-01-01

    Het bericht dat de Rijksuniversiteit Groningen overgaat op de mailvoorziening en agenda van Google Apps for Education bracht een golf van publiciteit teweeg. Mediaberichten naar aanleiding van de overgang naar Google Apps.

  9. Fitter door apps?

    NARCIS (Netherlands)

    Dallinga, Joan; Baart de la Faille-Deutekom, Marije

    2016-01-01

    In deze presentatie komen de volgende onderwerpen aan bod: wie gebruiken apps en wearables, resultaten onderzoek apps en leefstijl/gezondheid, nieuwe projecten waarin technologie ingezet wordt om bewegen te stimuleren en ideeen voor de toekomst.

  10. Google App Inventor

    CERN Document Server

    Roberts, Ralph

    2011-01-01

    This book is written in the Beginner's Guide format that takes the reader through a series of steps to build exciting apps using Google's App Inventor. This book is perfect for people with little or no experience, not just Android developers. No matter your level of experience, you will find plenty of information that you can use to create powerful apps, apps that can be published on Android Market and other places.

  11. The Business of iPhone App Development

    CERN Document Server

    Wooldridge, Dave

    2010-01-01

    The phenomenal success of the iPhone and the iPod touch has ushered in a "gold rush" for developers, but with well over 100,000 apps in the highly competitive App Store, it has become increasingly difficult for new apps to stand out in the crowd. Achieving consumer awareness and sales longevity for your iPhone app requires a lot of organization and some strategic planning. This book will show you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of succeeding in the App Store. The Business

  12. Biosynthesis of intestinal microvillar proteins. Processing of N-linked carbohydrate is not required for surface expression

    DEFF Research Database (Denmark)

    Danielsen, Erik Michael; Cowell, G M

    1986-01-01

    . The proteinase inhibitor leupeptin partially restored the suppressed synthesis, indicating that the majority of the wrongly processed enzymes, probably because of conformational instability, become degraded soon after synthesis rather than being transported to the microvillar membrane.......Castanospermine, an inhibitor of glucosidase I, the initial enzyme in the trimming of N-linked carbohydrate, was used to study the importance of carbohydrate processing in the biosynthesis of microvillar enzymes in organ-cultured pig intestinal explants. For aminopeptidase N (EC 3...

  13. Android apps security

    CERN Document Server

    Gunasekera, Sheran

    2012-01-01

    Android Apps Security provides guiding principles for how to best design and develop Android apps with security in mind. It explores concepts that can be used to secure apps and how developers can use and incorporate these security features into their apps. This book will provide developers with the information they need to design useful, high-performing, and secure apps that expose end-users to as little risk as possible.  Overview of Android OS versions, features, architecture and security.  Detailed examination of areas where attacks on applications can take place and what controls should b

  14. Android Apps for Absolute Beginners

    CERN Document Server

    Jackson, Wallace

    2011-01-01

    Anybody can start building simple apps for the Android platform, and this book will show you how! Android Apps for Absolute Beginners takes you through the process of getting your first Android applications up and running using plain English and practical examples. It cuts through the fog of jargon and mystery that surrounds Android application development, and gives you simple, step-by-step instructions to get you started.* Teaches Android application development in language anyone can understand, giving you the best possible start in Android development * Provides simple, step-by-step exampl

  15. High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice

    Directory of Open Access Journals (Sweden)

    Yunhua ePeng

    2014-08-01

    Full Text Available Osteoporosis is negatively correlated with body mass, whereas both osteoporosis and weight loss occur at higher incidence during the progression of Alzheimer’s disease (AD than the age-matched non-dementia individuals. Given that there is no evidence that overweight associated with AD-type cognitive dysfunction, we hypothesized that moderate weight gain might have a protective effect on the bone loss in AD without exacerbating cognitive dysfunction. In the present study, feeding a high-fat-diet (HFD, 45% calorie from fat to female APP/PS1 transgenic mice, an AD animal model, induced weight gain. The bone mineral density, microarchitecture, and biomechanical properties of the femurs were then evaluated. The results showed that the middle-aged female APP/PS1 transgenic mice were susceptible to osteoporosis of the femoral bones and that weight gain significantly enhanced bone mass and mechanical properties. Notably, HFD was not detrimental to brain insulin signaling and AβPP processing, as well as to exploration ability and working, learning and memory performance of the transgenic mice measured by T maze and water maze, compared with the mice fed a normal fat diet (10% calorie from fat. In addition, the circulating levels of leptin but not estradiol were remarkably elevated in HFD-treated mice. These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin.

  16. Mobile app and app store analysis, testing and optimisation

    OpenAIRE

    Harman, M.; Al-Subaihin, A.; Jia, Y.; Martin, W.; Sarro, F.; Zhang, Y.

    2016-01-01

    This talk presents results on analysis and testing of mobile apps and app stores, reviewing the work of the UCL App Analysis Group (UCLappA) on App Store Mining and Analysis. The talk also covers the work of the UCL CREST centre on Genetic Improvement, applicable to app improvement and optimisation.

  17. Programming Google App Engine

    CERN Document Server

    Sanderson, Dan

    2010-01-01

    As one of today's cloud computing services, Google App Engine does more than provide access to a large system of servers. It also offers you a simple model for building applications that scale automatically to accommodate millions of users. With Programming Google App Engine, you'll get expert practical guidance that will help you make the best use of this powerful platform. Google engineer Dan Sanderson shows you how to design your applications for scalability, including ways to perform common development tasks using App Engine's APIs and scalable services. You'll learn about App Engine's a

  18. In situ biosynthesis of bacterial nanocellulose-CaCO{sub 3} hybrid bionanocomposite: One-step process

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadkazemi, Faranak, E-mail: f_mkazemi@sbu.ac.ir [Department of Cellulose and Paper Technology, Faculty of New Technologies Engineering, Shahid Beheshti University, Science and Research Campus, Zirab, Savadkooh, Mazandaran (Iran, Islamic Republic of); Faria, Marisa; Cordeiro, Nereida [Faculty of Exact Science and Engineering, University of Madeira, Funchal (Portugal)

    2016-08-01

    In this work, a simple and green route to the synthesis of the bacterial nanocellulose-calcium carbonate (BNC/CaCO{sub 3}) hybrid bionanocomposites using one-step in situ biosynthesis was studied. The CaCO{sub 3} was incorporated in the bacterial nanocellulose structure during the cellulose biosynthesis by Gluconacetobacter xylinus PTCC 1734 bacteria. Hestrin-Schramm (HS) and Zhou (Z) culture media were used to the hybrid bionanocomposites production and the effect of ethanol addition was investigated. Attenuated total reflection Fourier transform infrared spectroscopy, field emission scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, inverse gas chromatography and thermogravimetric analysis were used to characterize the samples. The experimental results demonstrated that the ethanol and culture medium play an important role in the BNC/CaCO{sub 3} hybrid bionanocomposites production, structure and properties. The BNC/CaCO{sub 3} biosynthesized in Z culture medium revealed higher O/C ratio and amphoteric surface character, which justify the highest CaCO{sub 3} content incorporation. The CaCO{sub 3} was incorporated into the cellulosic matrix decreasing the bacterial nanocellulose crystallinity. This work reveals the high potential of in situ biosynthesis of BNC/CaCO{sub 3} hybrid bionanocomposites and opens a new way to the high value-added applications of bacterial nanocellulose. - Graphical Abstract: Display Omitted - Highlights: • BNC/CaCO{sub 3} hybrid bionanocomposites were produced using in situ biosynthesis process. • Ethanol and culture medium play an important role in the production and properties. • Z-BNC/CaCO{sub 3} bionanocomposites revealed higher O/C ratio and amphoteric surface character. • CaCO{sub 3} incorporated into the BNC decreased crystallinity.

  19. Sencha Architect app development

    CERN Document Server

    Groner, Loiane

    2013-01-01

    A standard tutorial-based approach for using Sencha Architect to develop applications in Ext JS and Sencha Touch.Sencha Architect App Development is for Ext JS and Sencha Touch developers that are looking to improve their productivity by using Sencha Architect for app development. Basic knowledge of Ext JS and Sencha Touch is required.

  20. Mobile Apps for Librarians

    Science.gov (United States)

    Power, June L.

    2013-01-01

    In an increasing mobile environment, library and reading-related activities often take place on a phone or tablet device. Not only does this mean that library Web sites must keep mobile navigability in mind, but also develop and utilize apps that allow patrons to interact with information and with libraries. While apps do not serve every purpose,…

  1. The Business of iPhone and iPad App Development Making and Marketing Apps That Succeed

    CERN Document Server

    Wooldridge, Dave

    2011-01-01

    The phenomenal success of the iPhone, iPad and the iPod touch has ushered in a "gold rush" for developers, but with well over 300,000 apps in the highly competitive App Store, it has become increasingly difficult for new apps to stand out in the crowd. Achieving consumer awareness and sales longevity for your iOS app requires a lot of organization and some strategic planning. Updated and expanded for iOS 4, this bestselling book will show you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of

  2. Using Google App Engine

    CERN Document Server

    Severance, Charles

    2009-01-01

    Build exciting, scalable web applications quickly and confidently using Google App Engine and this book, even if you have little or no experience in programming or web development. App Engine is perhaps the most appealing web technology to appear in the last year, providing an easy-to-use application framework with basic web tools. While Google's own tutorial assumes significant experience, Using Google App Engine will help anyone get started with this platform. By the end of this book, you'll know how to build complete, interactive applications and deploy them to the cloud using the same s

  3. Akut ultralyd App

    DEFF Research Database (Denmark)

    Todsen, Tobias; Graumann, Ole; Laursen, Christian B.;

    2015-01-01

    Denne app indeholder gennemgang af en række standardiserede ultralydsprotokoller, der kan udføres i forbindelse med undersøgelsen af den akutte patient til besvarelse af binære kliniske spørgsmål. App'en er blevet udviklet i et samarbejde mellem Københavns Universitet, Syddansk Universitet og...... Aarhus Universitet. Projektgruppen repræsenterer læger fra forskellige specialer og har alle beskæftiget sig med undervisning og forskning i klinisk ultralyd. App´en er gratis og kan hestes her: http://akutul.cekuapp.dk/...

  4. APP Metabolism Regulates Tau Proteostasis in Human Cerebral Cortex Neurons

    Directory of Open Access Journals (Sweden)

    Steven Moore

    2015-05-01

    Full Text Available Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD. To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, all of which increase the release of pathogenic Aβ peptides. We identified marked increases in intracellular tau in genetic forms of AD that either mutated APP or increased its dosage, suggesting that APP metabolism is coupled to changes in tau proteostasis. Manipulating APP metabolism by β-secretase and γ-secretase inhibition, as well as γ-secretase modulation, results in specific increases and decreases in tau protein levels. These data demonstrate that APP metabolism regulates tau proteostasis and suggest that the relationship between APP processing and tau is not mediated solely through extracellular Aβ signaling to neurons.

  5. Biosynthesis of intestinal microvillar proteins. Intracellular processing of lactase-phlorizin hydrolase

    DEFF Research Database (Denmark)

    Danielsen, E M; Skovbjerg, H; Norén, Ove

    1984-01-01

    The biosynthesis of pig small intestinal lactase-phlorizin hydrolase (EC 3.2.1.23-62) was studied by labelling of organ cultured mucosal explants with [35S]methionine. The earliest detactable form of the enzyme was an intracellular, membrane-bound polypeptide of Mr 225 000, sensitive to endo H...... 000 polypeptide is of the same size as the mature lactase-phlorizin hydrolase and was the only form expressed in the microvillar membrane. Together, these data are indicative of an intracellular proteolytic cleavage during transport. The presence of leupeptin during labelling prevented the appearance...

  6. Health Apps and How to Market Them

    OpenAIRE

    Hillenbrand, Susanna

    2016-01-01

    In future health apps may become as popular as mobile games and retail shopping apps. Some consumers even think that health app usage is more valuable than making or receiving calls. This multibillion industry of mobile software applications and especially health apps is relatively new. The main research topic was how to market health apps globally. Health apps like fitness, weight loss and wellness apps are new trend in apps business. Healthcare apps are divided into health- and medical apps...

  7. Optimization of process parameters for the rapid biosynthesis of hematite nanoparticles.

    Science.gov (United States)

    Rajendran, Kumar; Sen, Shampa

    2016-06-01

    Hematite (α-Fe2O3) nanoparticles are widely used in various applications including gas sensors, pigments owing to its low cost, environmental friendliness, non-toxicity and high resistance to corrosion. These nanoparticles were generally synthesized by different chemical methods. In the present study, nanoparticles were synthesized rapidly without heat treatment by biosynthesis approach using culture supernatant of Bacillus cereus SVK1. The physiochemical parameters for rapid synthesis were optimized by using UV-visible spectroscopy. The time taken for hematite nanoparticle synthesis was found to increase with the increasing concentration of the precursor. This might be due to the inadequate proportion of quantity of biomolecules present in the culture supernatant to the precursor which led to delayed bioreduction. Greater quantities of culture supernatant with respect to precursor lead to rapid synthesis of hematite nanoparticles. The nucleation of the hematite nucleus happens more easily when the solution pH was less than 10. The optimum parameters identified for the rapid biosynthesis of hematite nanoparticles were pH9, 37°C (temperature) and 1mM ferric chloride as precursor. The particles were well crystallized hexagonal structured hematite nanoparticles and are predominantly (110)-oriented. The synthesized nanoparticles were found to contain predominantly iron (73.47%) and oxygen (22.58%) as evidenced by Energy Dispersive X-ray analysis. Hematite nanoparticles of 15-40nm diameters were biosynthesized in 48h under optimized conditions, compared to 21days before optimization.

  8. New insights into Pseudomonas fluorescens alginate biosynthesis relevant for the establishment of an efficient production process for microbial alginates.

    Science.gov (United States)

    Maleki, Susan; Mærk, Mali; Hrudikova, Radka; Valla, Svein; Ertesvåg, Helga

    2017-07-25

    Alginate denotes a family of linear polysaccharides with a wide range of industrial and pharmaceutical applications. Presently, all commercially available alginates are manufactured from brown algae. However, bacterial alginates have advantages with regard to compositional homogeneity and reproducibility. In order to be able to design bacterial strains that are better suited for industrial alginate production, defining limiting factors for alginate biosynthesis is of vital importance. Our group has been studying alginate biosynthesis in Pseudomonas fluorescens using several complementary approaches. Alginate is synthesised and transported out of the cell by a multiprotein complex spanning from the inner to the outer membrane. We have developed an immunogold labelling procedure in which the porin AlgE, as a part of this alginate factory, could be detected by transmission electron microscopy. No time-dependent correlation between the number of such factories on the cell surface and alginate production level was found in alginate-producing strains. Alginate biosynthesis competes with the central carbon metabolism for the key metabolite fructose 6-phosphate. In P. fluorescens, glucose, fructose and glycerol, are metabolised via the Entner-Doudoroff and pentose phosphate pathways. Mutational analysis revealed that disruption of the glucose 6-phosphate dehydrogenase gene zwf-1 resulted in increased alginate production when glycerol was used as carbon source. Furthermore, alginate-producing P. fluorescens strains cultivated on glucose experience acid stress due to the simultaneous production of alginate and gluconate. The combined results from our studies strongly indicate that the availability of fructose 6-phosphate and energy requires more attention in further research aimed at the development of an optimised alginate production process.

  9. Scientific Opinion on the safety assessment of the process “APPE supercycle CP” used to recycle post-consumer PET into food contact materials

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF

    2014-04-01

    Full Text Available This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety evaluation of the recycling process APPE Supercycle CP (EU register No RECYC066. The input of the process is hot caustic washed and dried PET flakes originating from collected post-consumer PET containers, mainly bottles, containing no more than 5 % of PET from non-food consumer applications. Through this process, washed and dried PET flakes are extruded under vacuum and pelletised (step 2. The pellets are crystallised at high temperature under vacuum (step 3 and further decontaminated in a solid state polymerisation reactor (SSP at high temperature under vacuum. Having examined the challenge test provided, the Panel concluded that the three steps, the extrusion (step 2, the crystallisation (step 3 and the decontamination in the SSP reactor (step 4 are the critical steps for the decontamination efficiency of the process. The operating parameters to control their performance are the temperature, the gas flow, the pressure and the residence time. The operating parameters of these steps in the process are at least as severe as those obtained from the challenge test. Under these conditions, it was demonstrated that the recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below a conservatively modelled migration of 0.1 μg/kg food. Therefore the Panel concluded that the recycled PET obtained from this process intended to be used at up to 100 % for the manufacture of materials and articles for contact with all types of foodstuffs for long term storage at room temperature, with or without hotfill is not considered of safety concern.

  10. Scientific Opinion on the safety assessment of the process "APPE Supercycle B" used to recycle PET for use in food contact materials

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF

    2014-02-01

    Full Text Available This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety assessment of the recycling process APPE Supercycle B (EU register No RECYC065. The input of the process is hot caustic washed and dried PET flakes originating from collected post-consumer PET containers, mainly bottles, containing no more than 5 % of PET from non-food consumer applications. Through this process, washed and dried PET flakes are further dried at high temperature, extruded under vacuum and pelletised. The pellets are crystallised and then solid state polymerised (SSP in a reactor at high temperature under vacuum. Having examined the challenge test provided, the Panel concluded that the two steps, the crystallisation (step 4 and the decontamination in the SSP reactor (step 5 are the critical steps for the decontamination efficiency of the process. The operating parameters to control their performance are the temperature, pressure and residence time. The operating parameters of these steps in the process are at least as severe as those obtained from the challenge test. Under these conditions, it was demonstrated that the recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below a conservatively modelled migration of 0.1 μg/kg food. Therefore the Panel concluded that the recycled PET obtained from this process intended to be used at up to 100 % for the manufacture of materials and articles for contact with all types of foodstuffs for long term storage at room temperature, with or without hotfill is not considered of safety concern.

  11. Designing apps for success developing consistent app design practices

    CERN Document Server

    David, Matthew

    2014-01-01

    In 2007, Apple released the iPhone. With this release came tools as revolutionary as the internet was to businesses and individuals back in the mid- and late-nineties: Apps. Much like websites drove (and still drive) business, so too do apps drive sales, efficiencies and communication between people. But also like web design and development, in its early years and iterations, guidelines and best practices for apps are few and far between.Designing Apps for Success provides web/app designers and developers with consistent app design practices that result in timely, appropriate, and efficiently

  12. High glucose promotes Aβ production by inhibiting APP degradation.

    Directory of Open Access Journals (Sweden)

    Yi Yang

    Full Text Available Abnormal deposition of neuriticplaques is the uniqueneuropathological hallmark of Alzheimer's disease (AD.Amyloid β protein (Aβ, the major component of plaques, is generated from sequential cleavage of amyloidβ precursor protein (APP by β-secretase and γ-secretase complex. Patients with diabetes mellitus (DM, characterized by chronic hyperglycemia,have increased risk of AD development.However, the role of high blood glucose in APP processing and Aβ generation remains elusive. In this study, we investigated the effect of high glucose on APP metabolism and Aβ generation in cultured human cells. We found that high glucose treatment significantly increased APP protein level in both neuronal-like and non-neuronal cells, and promoted Aβ generation. Furthermore, we found that high glucose-induced increase of APP level was not due to enhancement of APP gene transcription but resulted from inhibition of APP protein degradation. Taken together, our data indicated that hyperglycemia could promote AD pathogenesis by inhibiting APP degradation and enhancing Aβ production. More importantly, the elevation of APP level and Aβ generation by high glucose was caused by reduction of APP turnover rate.Thus,our study provides a molecular mechanism of increased risk of developing AD in patients withDMand suggests thatglycemic control might be potentially beneficial for reducing the incidence of AD in diabetic patients and delaying the AD progression.

  13. Popularity Modeling for Mobile Apps: A Sequential Approach.

    Science.gov (United States)

    Zhu, Hengshu; Liu, Chuanren; Ge, Yong; Xiong, Hui; Chen, Enhong

    2015-07-01

    The popularity information in App stores, such as chart rankings, user ratings, and user reviews, provides an unprecedented opportunity to understand user experiences with mobile Apps, learn the process of adoption of mobile Apps, and thus enables better mobile App services. While the importance of popularity information is well recognized in the literature, the use of the popularity information for mobile App services is still fragmented and under-explored. To this end, in this paper, we propose a sequential approach based on hidden Markov model (HMM) for modeling the popularity information of mobile Apps toward mobile App services. Specifically, we first propose a popularity based HMM (PHMM) to model the sequences of the heterogeneous popularity observations of mobile Apps. Then, we introduce a bipartite based method to precluster the popularity observations. This can help to learn the parameters and initial values of the PHMM efficiently. Furthermore, we demonstrate that the PHMM is a general model and can be applicable for various mobile App services, such as trend based App recommendation, rating and review spam detection, and ranking fraud detection. Finally, we validate our approach on two real-world data sets collected from the Apple Appstore. Experimental results clearly validate both the effectiveness and efficiency of the proposed popularity modeling approach.

  14. Endogenous APP accumulates in synapses after BACE1 inhibition.

    Science.gov (United States)

    Nigam, Saket Milind; Xu, Shaohua; Ackermann, Frauke; Gregory, Joshua A; Lundkvist, Johan; Lendahl, Urban; Brodin, Lennart

    2016-08-01

    BACE1-mediated cleavage of APP is a pivotal step in the production of the Alzheimer related Aβ peptide and inhibitors of BACE1 are currently in clinical development for the treatment of Alzheimer disease (AD). While processing and trafficking of APP has been extensively studied in non-neuronal cells, the fate of APP at neuronal synapses and in response to reduced BACE1 activity has not been fully elucidated. Here we examined the consequence of reduced BACE1 activity on endogenous synaptic APP by monitoring N- and C-terminal APP epitopes by immunocytochemistry. In control rodent primary hippocampal neuron cultures, labeling with antibodies directed to N-terminal APP epitopes showed a significant overlap with synaptic vesicle markers (SV2 or synaptotagmin). In contrast, labeling with antibodies directed to C-terminal epitopes of APP showed only a limited overlap with these proteins. In neurons derived from BACE1-deficient mice, and in control neurons treated with a BACE1 inhibitor, both the N-terminal and the C-terminal APP labeling overlapped significantly with synaptic vesicle markers. Moreover, BACE1 inhibition increased the proximity between the APP C-terminus and SV2 as shown by a proximity ligation assay. These results, together with biochemical observations, indicate that BACE1 can regulate the levels of full-length APP at neuronal synapses.

  15. Pro Android Apps Performance Optimization

    CERN Document Server

    Guihot, Hervé

    2012-01-01

    Today's Android apps developers are often running into the need to refine, improve and optimize their apps performances. As more complex apps can be created, it is even more important for developers to deal with this critical issue. Android allows developers to write apps using Java, C or a combination of both with the Android SDK and the Android NDK. Pro Android Apps Performance Optimization reveals how to fine-tune your Android apps, making them more stable and faster. In this book, you'll learn the following: * How to optimize your Java code with the SDK, but also how to write and optimize

  16. GridAPPS-D

    Energy Technology Data Exchange (ETDEWEB)

    2017-03-28

    GridAPPS-D is an open-source, open architecture, standards based platform for development of advanced electric power system planning and operations applications. GridAPPS-D provides a documented data abstraction for the application developer enabling creation of applications that can be run in any compliant system or platform. This enables development of applications that are platform vendor independent applications and applications that take advantage of the possibility of data rich and data driven applications based on deployment of smart grid devices and systems.

  17. Instant AppFog

    CERN Document Server

    Wee, Pau Kiat

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This easy to follow, hands-on guide shows you how to deploy and manage your application within minutes.Instant AppFog Starter is great for developers who are new to AppFog and who are primarily working on code rather than infrastructure. This book is perfect for those who are looking to publish applications without an in-depth knowledge of servers, firewalls, and networking. It is assumed that you will have some experience of web development as

  18. Security Ads in Mobile Apps

    Directory of Open Access Journals (Sweden)

    Manasvi Kalra,

    2016-02-01

    Full Text Available The apps consist of advertisements to promote their products. Not all of them are appropriate to resume. Therefore various algorithms have been used in order to block those apps from existence but none of them is completely successful. In our app we are using an antivirus which can by default block those spy apps and remove them from the web page. The algorithm which has been used makes use of various ant viruses in the background which detect irrelevant and intimate apps and then our algorithm will demolish them. Certain apps are non-trustworthy where one click can spy all the mobile data. They block those apps and works on security. We are working on secure ads for mobile apps. It can also work as a basic antivirus where it detects the viruses like malwares in any of your installed apps or downloads. It will create a popup of discarding or keeping it. Mobile applications can be downloaded from anywhere like amazon, googleplay, apps store etc. There is no rigorous verification of an application when it is uploaded to the market. One can easily develop a malicious application and upload it to the app market. The user itself is responsible for accepting the risk of an app available from secondary markets. Therefore, we have decided to develop this app to make the market more secure and bounded. In future, It will take the mobile market while consuming minimal additional resources and preserving user privacy.

  19. Quantifying App Store Dynamics: Longitudinal Tracking of Mental Health Apps

    Science.gov (United States)

    Nicholas, Jennifer; Christensen, Helen

    2016-01-01

    Background For many mental health conditions, mobile health apps offer the ability to deliver information, support, and intervention outside the clinical setting. However, there are difficulties with the use of a commercial app store to distribute health care resources, including turnover of apps, irrelevance of apps, and discordance with evidence-based practice. Objective The primary aim of this study was to quantify the longevity and rate of turnover of mental health apps within the official Android and iOS app stores. The secondary aim was to quantify the proportion of apps that were clinically relevant and assess whether the longevity of these apps differed from clinically nonrelevant apps. The tertiary aim was to establish the proportion of clinically relevant apps that included claims of clinical effectiveness. We performed additional subgroup analyses using additional data from the app stores, including search result ranking, user ratings, and number of downloads. Methods We searched iTunes (iOS) and the Google Play (Android) app stores each day over a 9-month period for apps related to depression, bipolar disorder, and suicide. We performed additional app-specific searches if an app no longer appeared within the main search Results On the Android platform, 50% of the search results changed after 130 days (depression), 195 days (bipolar disorder), and 115 days (suicide). Search results were more stable on the iOS platform, with 50% of the search results remaining at the end of the study period. Approximately 75% of Android and 90% of iOS apps were still available to download at the end of the study. We identified only 35.3% (347/982) of apps as being clinically relevant for depression, of which 9 (2.6%) claimed clinical effectiveness. Only 3 included a full citation to a published study. Conclusions The mental health app environment is volatile, with a clinically relevant app for depression becoming unavailable to download every 2.9 days. This poses

  20. Smartphone App for Voice Disorders

    Science.gov (United States)

    ... Feature: Taste, Smell, Hearing, Language, Voice, Balance Smartphone App for Voice Disorders Past Issues / Fall 2013 Table ... Center First to Study Minimally Verbal Children / Smartphone App for Voice Disorders / Stop the World from Spinning / ...

  1. CLAS App ML

    NARCIS (Netherlands)

    Maher, Bridget; Hartkopf, Kathleen; Stieger, Lina; Schroeder, Hanna; Sopka, Sasa; Orrego, Carola; Drachsler, Hendrik

    2014-01-01

    This is a multi-language (ML) update of the CLAS App original design by Bridget Maher from the School of Medicine at University College Cork, Ireland. The current version has an improve counting mechanism and has been translated from English to Spanish, Catalan and German languages within the Europe

  2. Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.

    Directory of Open Access Journals (Sweden)

    Yan Zheng

    Full Text Available Alzheimer's disease (AD is the most common progressive neurodegenerative disease known to humankind. It is characterized by brain atrophy, extracellular amyloid plaques, and intracellular neurofibril tangles. β-Amyloid cascade is considered the major causative player in AD. Up until now, the mechanisms underlying the process of Aβ generation and accumulation in the brain have not been well understood. Tyro3 receptor belongs to the TAM receptor subfamily of receptor protein tyrosine kinases (RPTKs. It is specifically expressed in the neurons of the neocortex and hippocampus. In this study, we established a cell model stably expressing APPswe mutants and producing Aβ. We found that overexpression of Tyro3 receptor in the cell model significantly decreased Aβ generation and also down-regulated the expression of β-site amyloid precursor protein cleaving enzyme (BACE1. However, the effects of Tyro3 were inhibited by its natural ligand, Gas6, in a concentration-dependent manner. In order to confirm the role of Tyro3 in the progression of AD development, we generated an AD transgenic mouse model accompanied by Tyro3 knockdown. We observed a significant increase in the number of amyloid plaques in the hippocampus in the mouse model. More plaque-associated clusters of astroglia were also detected. The present study may help researchers determine the role of Tyro3 receptor in the neuropathology of AD.

  3. There's an App for that!

    Science.gov (United States)

    Dutton, Gail

    2011-01-01

    Important as training the sales force is, mobile training apps are being used for much more. Visual Eyes Inc., for example, has developed training apps for the U.S. military's combat medical teams that detail specific medical procedures, such as controlling hemorrhaging. Other apps, developed for corporations and government agencies, pass along…

  4. Oncogene K-Ras Affects the Processing of Amyloid Precursor Protein (APP) Through Regulating Its Phosphorylation at Thr668%原癌基因K-Ras调控APPThr668位点磷酸化及APP的切割

    Institute of Scientific and Technical Information of China (English)

    刘杨; 杨龙雨; 谢勇壮; 张弦; 许华曦; 张云武

    2012-01-01

    The expression of Ras is elevated during early stages of Alzheimer's disease. Here we investigated the effect of K-Ras on the processing of amyloid precursor protein (APP). The results showed that overexpression of K-Ras and its constitutively active mutant K-RasG12V could activate ERK1/2 and JNK pathways and induced phosphorylation of APP at"ftr668. While inhibition of the JNK pathway blocked the phosphorylation of APP. In addition, overexpression of K-Ras reduced the levels of sAPPf) and increased the levels of sAPPa but had no effect on the levels of AD AMI 0 and BACE1. Through biptin labeling experiment, we demonstrated that overexpression of K-Ras increased cell surface levels of APP without affecting the levels of tptal APP. Together, these results suggest that K-Ras can regulate APP phosphorylation and APP trafficking for its processing through the JNK pathway, implying that K-Ras may be a new target/pathway for regulating AD pathologies.%在阿尔茨海默症(Alzheimer's disease,AD)发病的早期,Ras蛋白所在的信号通路被激活,但具体作用机制还不清楚.探讨了K-Ras及其突变体K-RasG12V对淀粉样前体蛋白(amyloid precursor protein,APP)的剪切的影响.Western blot结果显示,过量表达K-Ras能够激活细胞外调节蛋白激酶1/2(extracellular signal-regulated kinase,ERK 1/2)、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)通路,并增加APP在Thr668的磷酸化;抑制JNK通路则阻断了K-Ras过表达所引起的APP Thr668磷酸化.此外,过表达K-Ras造成分泌到细胞外的sAPPα增加,而sAPPβ减少.通过生物素标记实验发现,过表达K-Ras使得APP在细胞膜上的定位增加,而细胞内APP总量没有改变.这些结果表明,过量表达K-Ras可以通过调控JNK的通路,增加APP在Thr668位点的磷酸化,造成APP在细胞膜上水平升高,导致APP向sAPPβ的切割减少,而向sAPPα的切割增加.提示K-Ras对APP切割的影响可能在AD的发病过程中起着一定的应激作用.

  5. Mobile Apps to Support and Assess Foreign Language Learning

    Science.gov (United States)

    Berns, Anke; Palomo-Duarte, Manuel; Dodero, Juan Manuel; Ruiz-Ladrón, Juan Miguel; Márquez, Andrea Calderón

    2015-01-01

    In the last two decades there have been many attempts to integrate all kinds of mobile devices and apps to support formal as well as informal learning processes. However, most of the available apps still support mainly individual learning, using mobile devices to deliver content rather than providing learners with the opportunity to interact with…

  6. Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “in vivo” by P2X7 receptor

    Directory of Open Access Journals (Sweden)

    M. Teresa Miras-Portugal

    2015-01-01

    The in vivo approach was made possible by the use of J20 mice, a transgenic mouse model of familial Alzheimer's disease (FAD expressing human APP mutant protein. This animal exhibits prominent amyloid plaques by six months of age. In vivo inhibition of the P2X7 receptor induced a significant decrease in the number and size of hippocampal amyloid plaques. This reduction is mediated by an increase in the proteolytic processing of APP through α-secretase activity, which correlates with an increase in the phosphorylated form of GSK-3, a less active form of this enzyme. The in vivo findings corroborate the therapeutic potential of P2X7 antagonists in the treatment of FAD.

  7. Optimization of process variables for the biosynthesis of silver nanoparticles by Aspergillus wentii using statistical experimental design

    Science.gov (United States)

    Biswas, Supratim; Mulaba-Bafubiandi, Antoine F.

    2016-12-01

    The present scientific endeavour focuses on the optimization of process parameters using central composite design towards development of an efficient technique for the biosynthesis of silver nanoparticles. The combined effects of three process variables (days of fermentation, duration of incubation, concentration of AgNO3) upon extracellular biological synthesis of silver nanoparticles (AgNPs) by Aspergillus wentii NCIM 667 were studied. A single absorption peak at 455 nm confirming the presence of silver nanoparticles was observed in the UV-visible spectrophotometric graph. Using Fourier transform infrared spectroscopic analysis the presence of proteins as viable reducing agents for the formation AgNPs was recorded. High resolution transmission electron microscopy showed the realization of spherically shaped AgNPs of size 15-40 nm. Biologically formed AgNPs revealed higher antimicrobial activity against gram-negative than gram-positive bacterial strains. We present the enumeration of the properties of biosynthesized nanoparticles which exhibit photocatalysis exhausting an organic dye, the methyl orange, upon exposure to sunlight thereby accomplishing the degradation of almost (88%) the methyl orange dye within 5 h.

  8. Oyster Fisheries App

    Science.gov (United States)

    Perez Guerrero, Geraldo A.; Armstrong, Duane; Underwood, Lauren

    2015-01-01

    This project is creating a cloud-enabled, HTML 5 web application to help oyster fishermen and state agencies apply Earth science to improve the management of this important natural and economic resource. The Oyster Fisheries app gathers and analyzes environmental and water quality information, and alerts fishermen and resources managers about problems in oyster fishing waters. An intuitive interface based on Google Maps displays the geospatial information and provides familiar interactive controls to the users. Alerts can be tailored to notify users when conditions in specific leases or public fishing areas require attention. The app is hosted on the Amazon Web Services cloud. It is being developed and tested using some of the latest web development tools such as web components and Polymer.

  9. Tapworthy Designing Great iPhone Apps

    CERN Document Server

    Clark, Josh

    2010-01-01

    So you've got an idea for an iPhone app -- along with everyone else on the planet. Set your app apart with elegant design, efficient usability, and a healthy dose of personality. This accessible, well-written guide shows you how to design exceptional user experiences for the iPhone and iPod Touch through practical principles and a rich collection of visual examples. Whether you're a designer, programmer, manager, or marketer, Tapworthy teaches you to "think iPhone" and helps you ask the right questions -- and get the right answers -- throughout the design process. You'll explore how consider

  10. Process analysis of macrotetrolide biosynthesis during fermentation by means of direct infusion LC-MS.

    Science.gov (United States)

    Jani, Peter; Emmert, Joachim; Wohlgemuth, Roland

    2008-02-01

    The optimization of the biosynthetic pathways is highly attractive for the large-scale preparation of macrotetrolides, because overall yields in the chemical synthesis of compounds like nonactin have been very low. A key success factor determining the outcome of such optimizations is the adequate process analysis for the envisioned product. The analytical methods for process control involved in the past spectrophotometric and chromatographic measurements. LC-MS offers a modern approach to obtain more detailed data than the spectrophotometric and chromatographic measurements used in the past. In this work, a fast and versatile analytical LC-MS method has been set up, which has proven of much value for the in-process analysis of macrotetrolides during fermentation and which has allowed rapid large-scale bioprocess development.

  11. Biosynthesis of selenium nanoparticles using Klebsiella pneumoniae and their recovery by a simple sterilization process

    Directory of Open Access Journals (Sweden)

    Parisa Jafari Fesharaki

    2010-06-01

    Full Text Available The use of biologically derived metal nanoparticles for various proposes is going to be an issue of considerable importance; thus, appropriate methods should be developed and tested for the biological synthesis and recovery of these nanoparticles from bacterial cells. In this research study, a strain of Klebsiella pneumoniae was tested for its ability to synthesize elemental selenium nanoparticles from selenium chloride. A broth of Klebsiella pneumoniae culture containing selenium nanoparticles was subjected to sterilization at 121ºC and 17 psi for 20 minutes. Released selenium nanoparticles ranged in size from 100 to 550 nm, with an average size of 245 nm. Our study also showed that no chemical changes occurred in selenium nanoparticles during the wet heat sterilization process. Therefore, the wet heat sterilization process can be used successfully to recover elemental selenium from bacterial cells.

  12. Designing of an intensification process for biosynthesis and recovery of menaquinone-7.

    Science.gov (United States)

    Berenjian, Aydin; Mahanama, Raja; Talbot, Andrea; Regtop, Hubert; Kavanagh, John; Dehghani, Fariba

    2014-02-01

    A nutritional food rich in menaquinone-7 has a potential in preventing osteoporosis and cardiovascular diseases. The static fermentation of Bacillus subtilis natto is widely regarded as an optimum process for menaquinone-7 production. The major issues for the bulk production of menaquinone-7 are the low fermentation yield, biofilm formation and the use of organic solvents for the vitamin extraction. In this study, we demonstrate that the dynamic fermentation involving high stirring and aeration rates enhances the yield of fermentation process significantly compared to static system. The menaquinone-7 concentration of 226 mg/L was produced at 1,000 rpm, 5 vvm, 40 °C after 5 days of fermentation. This concentration is 70-fold higher than commercially available food products such as natto. Additionally, it was found that more than 80% of menaquinone-7 was recovered in situ in the vegetable oil that was gradually added to the system as an anti-foaming agent. The intensification process developed in this study has a capacity to produce an oil rich in menaquinone-7 in one step and eliminate the use of organic solvents for recovery of this compound. This oil can, therefore, be used for the preparation of broad range of supplementary and dietary food products rich in menaquinone-7 to reduce the risk of osteoporotic fractures and cardiovascular diseases.

  13. Aflatoxin biosynthesis: current frontiers.

    Science.gov (United States)

    Roze, Ludmila V; Hong, Sung-Yong; Linz, John E

    2013-01-01

    Aflatoxins are among the principal mycotoxins that contaminate economically important food and feed crops. Aflatoxin B1 is the most potent naturally occurring carcinogen known and is also an immunosuppressant. Occurrence of aflatoxins in crops has vast economic and human health impacts worldwide. Thus, the study of aflatoxin biosynthesis has become a focal point in attempts to reduce human exposure to aflatoxins. This review highlights recent advances in the field of aflatoxin biosynthesis and explores the functional connection between aflatoxin biosynthesis, endomembrane trafficking, and response to oxidative stress. Dissection of the regulatory mechanisms involves a complete comprehension of the aflatoxin biosynthetic process and the dynamic network of transcription factors that orchestrates coordinated expression of the target genes. Despite advancements in the field, development of a safe and effective multifaceted approach to solve the aflatoxin food contamination problem is still required.

  14. Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

    Science.gov (United States)

    Mockett, Bruce G.; Richter, Max; Abraham, Wickliffe C.; Müller, Ulrike C.

    2017-01-01

    Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great potential as a therapeutic target. For example, APPsα is neurotrophic, neuroprotective, neurogenic, a stimulator of protein synthesis and gene expression, and enhances long-term potentiation (LTP) and memory. While most early studies have been conducted in vitro, effectiveness in animal models is now being confirmed. These studies have revealed that either upregulating α-secretase activity, acutely administering APPsα or chronic delivery of APPsα via a gene therapy approach can effectively treat mouse models of Alzheimer’s disease (AD) and other disorders such as traumatic head injury. Together these findings suggest the need for intensifying research efforts to harness the therapeutic potential of this multifunctional protein.

  15. Amazing Android Apps For Dummies

    CERN Document Server

    Begun, Daniel A

    2011-01-01

    Find the Android apps that are right for you so you can have fun and get more done!The popularity of Android apps is exploding and this handy guide helps you sort through the thousands of available applications so you can find the ones that are ideal for you. You'll explore a variety of apps in the areas of entertainment, finance, health, food, music, news, weather, photography, reference, dining out, social networking, sports, travel, and more. Author Daniel Begun helps you navigate through this enormous-and potentially overwhelming-array of Android apps.Holds your hand through the oftentimes

  16. Pro Java ME Apps

    CERN Document Server

    Iliescu, Ovidiu

    2011-01-01

    Pro Java ME Apps gives you, the developer, the know-how required for writing sophisticated Java ME applications and for taking advantage of this huge potential market. Java ME is the largest mobile software platform in the world, supported by over 80% of all phones. You'll cover what Java ME is and how it compares to other mobile software platforms, how to properly design and structure Java ME applications, how to think like an experienced Java ME developer, what common problems and pitfalls you may run into, how to optimize your code, and many other key topics. Unlike other Java ME books out

  17. The CLAS App - A training app to improve medical handovers

    NARCIS (Netherlands)

    Maher, Bridget; Drachsler, Hendrik; Kalz, Marco; Marcus, Specht

    2012-01-01

    Maher, B., Drachsler, H., Kalz, M., & Specht, M. (2012, 16-18 October). The CLAS App - A training app to improve medical handovers. Presentation at the 11th World Conference on Mobile and Contextual Learning, Helsinki, Finland. Please see also: http://hdl.handle.net/1820/4613

  18. Governance mechanisms for healthcare apps

    DEFF Research Database (Denmark)

    Manikas, Konstantinos; Hansen, Klaus Marius; Kyng, Morten

    2014-01-01

    The introduction of the `app store' concept has challenged the way software is distributed and marketed: developers have easier access to customers, while customers have easy access to innovative applications. Apps today are increasingly focusing on more "mission-critical" areas like healthcare w...

  19. Residual effects of low oxygen storage of mature green fruit on ripening processes and ester biosynthesis during ripening in bananas

    Science.gov (United States)

    Mature green banana (Musa sapientum L. cv. Cavendish) fruit were stored in 0.5%, 2 %, or 21% O2 for 7 days at 20 °C before ripening was initiated by ethylene. Residual effects of low O2 storage in mature green fruit on ripening and ester biosynthesis in fruit were investigated during ripening period...

  20. Moving Phones Tick Slower: Creating an Android App to Demonstrate Time Dilation

    Science.gov (United States)

    Underwood, Bret; Zhai, Yunxiao

    2016-05-01

    Smartphones and tablets are packed with sensors that allow us to take experimental data, essentially making them mobile physics labs. Apps exist that make it easy to capture and analyze data from these sensors, allowing users to study diverse phenomena such as free fall acceleration, the speed of sound, radioactivity, and many others. Commonly, the use of apps in the physics classroom focuses on existing apps rather than on the creation of apps themselves. This is for a good reason-writing an app usually requires advanced knowledge of programming languages and experience with app design. These skills are generally regarded as beyond the typical physics student. However, there are app development environments, such as MIT App Inventor 2 for Android, which make the process of creating an app and utilizing the sensors much more accessible to students. Putting the ability to create and configure apps within the reach of students can also help integrate computation into the curriculum. In this article, we discuss our creation of an Android app, Time Dilation Calculator, done as part of a senior undergraduate capstone project, which uses App Inventor and a mobile device's global positioning system (GPS) receiver to calculate the time dilation effect of special relativity.

  1. Best iPhone Apps

    CERN Document Server

    Biersdorfer, J

    2010-01-01

    With over 250,000 apps to choose from in Apple's App Store, you can make your iPhone or iPod Touch do just about anything you can imagine -- and almost certainly a few things you would never think of. While it's not hard to find apps, it is frustratingly difficult to find the the best ones. That's where this new edition of Best iPhone Apps comes in. New York Times technology columnist J.D. Biersdorfer has stress-tested hundreds of the App Store's mini-programs and hand-picked more than 200 standouts to help you get work done, play games, stay connected with friends, explore a new city, get i

  2. Your Life in Web Apps

    CERN Document Server

    Turnbull, Giles

    2008-01-01

    What is a web app? It's software that you use right in your web browser. Rather than installing an application on your computer, you visit a web site and sign up as a new user of its software. Instead of storing your files on your own hard disk, the web app stores them for you, online. Is it possible to switch entirely to web apps? To run nothing but a browser for an entire day? In this PDF we'll take you through one day in the life of a web apps-only user and chronicle the pros and cons of living by browser. And if the idea of switching, fully or partially, to web apps sounds appealing to

  3. GPLSI Compendium App

    OpenAIRE

    Jiménez Pérez, Antonio; Lloret, Elena; Gómez Soriano, José Manuel

    2015-01-01

    GPLSI Compendium App se trata de una aplicación móvil que hará las veces de un sistema de gestión y difusión de contenidos digitales, en la que el usuario podrá realizar resúmenes de textos de diferentes webs, tales como artículos o noticias, y posteriormente compartir esos resúmenes en sus redes sociales o a través del correo. Se le proporcionarán varios métodos de resumen, así como las descripciones y un pequeño tutorial de cómo utilizar la aplicación.

  4. Selecting "App"ealing and "App"ropriate Book Apps for Beginning Readers

    Science.gov (United States)

    Cahill, Maria; McGill-Franzen, Anne

    2013-01-01

    Beginning with a brief rationale for selecting quality digital picture book apps for beginning readers, the authors describe the elements of digital picture books and provide a brief review of the instructional benefits of digital picture book use for beginning readers. They then present a detailed taxonomy for selecting quality picture book apps.…

  5. The LibX LibApp Builder

    OpenAIRE

    Vijay, Sony

    2014-01-01

    LibX is a browser extension that provides direct access to library resources. LibX enables users to add additional features to a webpage, such as placing a tutorial video on a digital library homepage. LibX achieves this ability of enhancing web pages through library applications, called LibApps. A LibApp examines a webpage, extracts and processes information of the page, and modifies the web content. It is possible to build an unlimited number of LibApps and enhance web pages in numerous way...

  6. Be smart: Download the app!

    CERN Multimedia

    Katarina Anthony

    2013-01-01

    What’s the closest snack point to the CLIC test facility? How do you get from your current location to SM18? How do you enter the CERN Open Days photo contest? Finding out is simple: there’s an app for that!   The CERN Open Days app is your personal guide to the Laboratory. Developed by expert volunteers from the IT Department, the app provides comprehensive practical information on CERN transport, shops, snack points and toilet facilities along with detailed location information and event timetables. You can also favourite the sites, activities and lectures you plan to see, and tick them off as you go along. More information here.

  7. Getting started with Google Apps

    CERN Document Server

    Darbyshire, Paul

    2012-01-01

    First or one of the first books on now Final version (no longer Beta) of Google Apps with coverage of the new Chrome OS. Google Apps is expected to be a leading suite of ""Office-like"" online applications, free for the consumer and only 50 per year for business licenses. Google Apps already has over 1 Million business users and more consumer users, as of mid 2009 - to be showcased on Chrome enabled Netbooks (3-4) and Android Smart phones (up to 20) at Consumer Electronics Show (CES) in January 2010.

  8. Efficiently, Effectively Detecting Mobile App Bugs with AppDoctor

    Science.gov (United States)

    2014-04-01

    most FPs with a new algorithm that selectively switches between approxi- mate and faithful executions. By coupling these two modes of executions...this problem, AppDoctor again embraces approximation, and employs a novel algorithm and action dependency definition to effec- tively slice out many...devices that do not have AppDoctor installed, providing the same level of diagnosis help to developers as Monkey . FP example. Another approach to test

  9. Smartphone use in neurosurgery? APP-solutely!

    Directory of Open Access Journals (Sweden)

    Michael Zaki

    2014-01-01

    Conclusions: There are a number of neurosurgery-themed apps available to all audiences. There was a lack of patient information apps for nonspinal procedures. Most apps did not have enough reviews to evaluate their quality. There was also a lack of oversight to validate the accuracy of medical information provided in these apps.

  10. Een eigen Bibliotheek-app

    NARCIS (Netherlands)

    den Hollander, Franciscus; Veldkamp, Jan Herman

    2013-01-01

    Al enige tijd bestond bij de Bibliotheek RUG het verlangen om de producten en diensten van de bibliotheek op eigentijdse wijze onder de aandacht te brengen van haar gebruikers. Via een app op de mobiele telefoon, dus.

  11. Python for Google app engine

    CERN Document Server

    Pippi, Massimiliano

    2015-01-01

    If you are a Python developer, whether you have experience in web applications development or not, and want to rapidly deploy a scalable backend service or a modern web application on Google App Engine, then this book is for you.

  12. Instant Citrix XenApp

    CERN Document Server

    Mallett, Andrew

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is a great tool to quickly learn and explore the features offered by XenApp 6.5.Windows system administrators who want a quick lesson on how to install and configure XenApp.

  13. Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP.

    Directory of Open Access Journals (Sweden)

    Maria Merezhko

    Full Text Available Amyloid-β precursor protein (APP plays a central role in pathogenesis of Alzheimer's disease. APP has a short half-life and undergoes complex proteolytic processing that is highly responsive to various stimuli such as changes in cellular lipid or energy homeostasis. Cellular trafficking of APP is controlled by its large protein interactome, including dozens of cytosolic adaptor proteins, and also by interactions with lipids. Currently, cellular regulation of APP is mostly studied based on appearance of APP-derived proteolytic fragments to conditioned media and cellular extracts. Here, we have developed a novel live-cell assay system based on several indirect measures that reflect altered APP trafficking and processing in cells. Protein-fragment complementation assay technology for detection of APP-BACE1 protein-protein interaction forms the core of the new assay. In a multiplex form, the assay can measure four endpoints: total cellular APP level, total secreted sAPP level in media, APP-BACE1 interaction in cells and in exosomes released by the cells. Functional validation of the assay with pharmacological and genetic tools revealed distinct patterns of cellular fates of APP, with immediate mechanistic implications. This new technology will facilitate functional genomics studies of late-onset Alzheimer's disease, drug discovery efforts targeting APP and characterization of the physiological functions of APP and its proteolytic fragments.

  14. Designing platform independent mobile apps and services

    CERN Document Server

    Heckman, Rocky

    2016-01-01

    This book explains how to help create an innovative and future proof architecture for mobile apps by introducing practical approaches to increase the value and flexibility of their service layers and reduce their delivery time. Designing Platform Independent Mobile Apps and Services begins by describing the mobile computing landscape and previous attempts at cross platform development. Platform independent mobile technologies and development strategies are described in chapter two and three. Communication protocols, details of a recommended five layer architecture, service layers, and the data abstraction layer are also introduced in these chapters. Cross platform languages and multi-client development tools for the User Interface (UI) layer, as well as message processing patterns and message routing of the Service Int rface (SI) layer are explained in chapter four and five. Ways to design the service layer for mobile computing, using Command Query Responsibility Segregation (CQRS) and the Data Abstraction La...

  15. The Analysis Of Smartphone Apps In Geomatics Education

    Science.gov (United States)

    Teo, T.-A.; Wu, H.-M.; Shih, T.-Y.; Tsai, F.

    2014-04-01

    Geomatics is a discipline of collecting, processing and analysing geospatial data. Data collection is a core process of geomatics which usually adopt precise equipment to measure geospatial data. With the development of technology, a smartphone in this present era is not simply for communication; several low cost measurement devices such as Global Positioning System (GPS), gyro and camera are assembled in a smartphone. Although the devices assembled in a smartphone could not meet the needs of accuracy requirement for many geomatics applications, millions of mobile applications (Apps) can be downloaded and installed from Google Play and Apple Store freely, and a variety of sensors can be chosen for user. Considering that the popularity and convenience of a smartphone, and assuming that the accuracy of those collected data is acceptable for learning purposes, it is expected that a smartphone can be employed in geomatics for hand-on education. For example, Vespucci OSM Editor is an App to edit the OpenStreetMap on Android. The user may have the hand-on experience on GPS positioning, web services and mapping via Vespucci OSM Editor. The aim of this paper is to collect and analyze different Apps for geomatics education. The Apps are classified into four categories, namely, surveying, remote sensing, GPS and Geographic Information System (GIS). In this paper, more than 20 free Apps are collected and analysed for different hand-on studies in geomatics education. Finally, all the related Apps are listed on a website for updating.

  16. Unlocking how start-ups create business value with mobile applications: Development of an App-enabled Business Innovation Cycle

    NARCIS (Netherlands)

    Ehrenhard, Michel; Wijnhoven, Fons; Broek, van den Tijs; Zinck Stagno, Marc

    2017-01-01

    Little is known about the business value that mobile applications (apps) can create, and how start-ups can leverage this value. We present a multiple-case study to both explain the process of app-enabled value creation and the type of value outcomes associated with the use of apps for business purpo

  17. Unlocking how start-ups create business value with mobile applications: Development of an App-enabled Business Innovation Cycle

    NARCIS (Netherlands)

    Ehrenhard, Michel; Wijnhoven, Fons; Broek, van den Tijs; Zinck Stagno, Marc

    2016-01-01

    Little is known about the business value that mobile applications (apps) can create, and how start-ups can leverage this value. We present a multiple-case study to both explain the process of app-enabled value creation and the type of value outcomes associated with the use of apps for business purpo

  18. FAD-mutation of APP is associated with a loss of its synaptotrophic activity.

    Science.gov (United States)

    Seeger, Gudrun; Gärtner, Ulrich; Ueberham, Uwe; Rohn, Susanne; Arendt, Thomas

    2009-08-01

    Alzheimer's disease (AD) is a chronic neurodegenerative disorder associated with extracellular accumulation of Abeta peptide that derives from the amyloid precursor protein (APP). While amyloidogenic processing of APP has received most attention, the physiological function of APP and the sequelae of potentially impaired APP function are less understood. APP is a transmembrane glycoprotein being widely expressed in neurons in both central and peripheral nervous system. Its physiological function has been associated with neuronal survival, neurite outgrowth and neuronal plasticity. The aim of the present study was to determine whether FAD-linked mutations of APP, known to be associated with early onset of the disease, might impair its synaptotrophic function, potentially contributing to synaptic deficiencies seen in AD. We performed a quantitative electron microscopy study on synapses in well characterized expression-matched transgenic mice lines expressing either wildtype or FAD-mutated hAPP. Using serial electron microscopic sections, we comparatively analyzed by stereological methods the number and sizes of synaptic contacts and the number of synaptic vesicles in the neocortex. We could clearly show a synaptotrophic effect in mice overexpressing wildtype hAPP evidenced by a significant increase in the number of synapses and the number of vesicles per synapse. This effect was abolished when FAD-mutated APP(Sw,Ind) was expressed instead of wildtype APP. The present study demonstrates a synaptotrophic effect of APP which is lost in the presence of a FAD-mutation. This failure could either be due to a synaptotoxic effect of Abeta potentially counteracting the synaptotrophic effect of APP. Alternatively, the FAD-mutation might impair the physiological function of the extracellular domain of APP and its fragments which might be required for the synaptotrophic effect. This suggests that not only "too much Abeta" but also "too less functional intact APP" might be relevant

  19. Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

    Science.gov (United States)

    Breitkopf, Susanne B; Yuan, Min; Helenius, Katja P; Lyssiotis, Costas A; Asara, John M

    2015-11-03

    The combination of metabolomics, lipidomics, and phosphoproteomics that incorporates triple stable isotope labeling by amino acids in cell culture (SILAC) protein labeling, as well as (13)C in vivo metabolite labeling, was demonstrated on BCR-ABL-positive H929 multiple myeloma cells. From 11 880 phosphorylation sites, we confirm that H929 cells are primarily signaling through the BCR-ABL-ERK pathway, and we show that imatinib treatment not only downregulates phosphosites in this pathway but also upregulates phosphosites on proteins involved in RNA expression. Metabolomics analyses reveal that BCR-ABL-ERK signaling in H929 cells drives the pentose phosphate pathway (PPP) and RNA biosynthesis, where pathway inhibition via imatinib results in marked PPP impairment and an accumulation of RNA nucleotides and negative regulation of mRNA. Lipidomics data also show an overall reduction in lipid biosynthesis and fatty acid incorporation with a significant decrease in lysophospholipids. RNA immunoprecipitation studies confirm that RNA degradation is inhibited with short imatinib treatment and transcription is inhibited upon long imatinib treatment, validating the triomics results. These data show the utility of combining mass spectrometry-based "-omics" technologies and reveals that kinase inhibitors may not only downregulate phosphorylation of their targets but also induce metabolic events via increased phosphorylation of other cellular components.

  20. Psych-related iPhone apps.

    Science.gov (United States)

    Harrison, Anthony Mark; Goozee, Rhianna

    2014-02-01

    iPhone apps are a widely utilised technology that have recently been identified as a useful medium for health research, clinical interventions and education. While some researchers have discussed advances in app technology, others promote specific apps that are not free to access. To our knowledge, no study has conducted a review of current, free iPhone apps related to psychology, psychiatry and mental health. Therefore, we conducted a pilot, web-based review exploring free iPhone apps using a replicable search strategy within the iTunes Store search function. A selection of apps were selected and subjectively assessed in terms of their usability, utility, graphics, and associated costs for the consumer. We concluded that the apps reviewed, though novel, are limited in their scope and utility. We also note a significant gap in more scientific, evidence-based app technology, and pose some pertinent ethical questions when developing future psych-related apps.

  1. APP Snrinn Edition Kicks Off

    Institute of Scientific and Technical Information of China (English)

    Tang Rong

    2012-01-01

    When European textile insiders still take delight in talking about the last apparel sourcing show in September 2011, the debut of APP Spring edition bring people back to the Le Bourget Expo Center, with entire passion. The 7th APP Show, sponsored by China National Textile and Apparel Council (CNTAC), organized by the Sub-Council of Textile Industry, China Council for the Promotion of International Trade (CCPIT TEX), China National Garment Association and Messe Frankfurt French Subsidiary, was on display from Feb 13th to 16th 2012,

  2. MIT App Inventor: Enabling Personal Mobile Computing

    OpenAIRE

    Pokress, Shaileen Crawford; Veiga, José Juan Dominguez

    2013-01-01

    MIT App Inventor is a drag-and-drop visual programming tool for designing and building fully functional mobile apps for Android. App Inventor promotes a new era of personal mobile computing in which people are empowered to design, create, and use personally meaningful mobile technology solutions for their daily lives, in endlessly unique situations. App Inventor's intuitive programming metaphor and incremental development capabilities allow the developer to focus on the logic for programming ...

  3. The best 100 free apps for libraries

    CERN Document Server

    Hahn, Jim

    2013-01-01

    Librarian Jim Hahn has carefully culled the over 500,000 available apps down to the 100 that are the absolute best for day-in, day-out library services. The guide covers apps from both Apple and Android devices, including tablets. This guide is intended as an introduction for those with little or no app experience and for those wanting to know more about app uses for information access.

  4. Color Addition and Subtraction Apps

    Science.gov (United States)

    Ruiz, Frances; Ruiz, Michael J.

    2015-01-01

    Color addition and subtraction apps in HTML5 have been developed for students as an online hands-on experience so that they can more easily master principles introduced through traditional classroom demonstrations. The evolution of the additive RGB color model is traced through the early IBM color adapters so that students can proceed step by step…

  5. Electronic Discharge Letter Mobile App

    NARCIS (Netherlands)

    Lezcano, Leonardo; Triana, Michel; Ternier, Stefaan; Hartkopf, Kathleen; Stieger, Lina; Schroeder, Hanna; Sopka, Sasa; Drachsler, Hendrik; Maher, Bridget; Henn, Patrick; Orrego, Carola; Marcus, Specht

    2014-01-01

    The electronic discharge letter mobile app takes advantage of Near Field Communication (NFC) within the PATIENT project and a related post-doc study. NFC enabled phones to read passive RFID tags, but can also use this short-range wireless technology to exchange (small) messages. NFC in that sense co

  6. Capitalizing on App Development Tools and Technologies

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    Instructional developers and others creating apps must choose from a wide variety of app development tools and technologies. Some app development tools have incorporated visual programming features, which enable some drag and drop coding and contextual programming. While those features help novices begin programming with greater ease, questions…

  7. Citrix XenApp performance essentials

    CERN Document Server

    Dentella, Luca

    2013-01-01

    A practical hands-on tutorial including multiple examples on application management using Citrix XenApp 6.5.Citrix XenApp Performance Essentials is intended for IT architects and system administrators who work with Citrix XenApp and who need an agile, practical guide to tune and optimize the performance.

  8. 15 CFR 740.7 - Computers (APP).

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Computers (APP). 740.7 Section 740.7... Computers (APP). (a) Scope—(1) Commodities. License Exception APP authorizes exports and reexports of computers, including “electronic assemblies” and specially designed components therefor controlled by...

  9. App Inventor for Android Build Your Own Apps - No Experience Required!

    CERN Document Server

    Tyler, Jason

    2011-01-01

    Create Android mobile apps, no programming required! Even with limited programming experience, you can easily learn to create apps for the Android platform with this complete guide to App Inventor for Android. App Inventor for Android is a visual language that relies on simple programming blocks that users can drag and drop to create apps. This handy book gives you a series of fully worked-out apps, complete with their programming blocks, which you can customize for your own use or use as a starting point for creating the next killer app. And it's all without writing a single line of code. Don

  10. eFOIA App

    Data.gov (United States)

    Department of Homeland Security — By conveying the online request process to mobile devices, requesters can submit requests and check the status of existing requests anyplace, anytime. The mobile...

  11. Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine.

    Science.gov (United States)

    Marutle, Amelia; Ohmitsu, Masao; Nilbratt, Mats; Greig, Nigel H; Nordberg, Agneta; Sugaya, Kiminobu

    2007-07-24

    In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) may prevent neuronal differentiation of HNSCs. Thus, successful neuroplacement therapy for AD may require regulating APP expression to favorable levels to enhance neuronal differentiation of HNSCs. Phenserine, a recently developed cholinesterase inhibitor (ChEI), has been reported to reduce APP levels in vitro and in vivo. In this study, we found reductions of APP and glial fibrillary acidic protein (GFAP) levels in the hippocampus of APP23 mice after 14 days treatment with (+)-phenserine (25 mg/kg) lacking ChEI activity. No significant change in APP gene expression was detected, suggesting that (+)-phenserine decreases APP levels and reactive astrocytes by posttranscription regulation. HNSCs transplanted into (+)-phenserine-treated APP23 mice followed by an additional 7 days of treatment with (+)-phenserine migrated and differentiated into neurons in the hippocampus and cortex after 6 weeks. Moreover, (+)-phenserine significantly increased neuronal differentiation of implanted HNSCs in hippocampal and cortical regions of APP23 mice and in the CA1 region of control mice. These results indicate that (+)-phenserine reduces APP protein in vivo and increases neuronal differentiation of HNSCs. Combination use of HNSC transplantation and treatment with drugs such as (+)-phenserine that modulate APP levels in the brain may be a useful tool for understanding mechanisms regulating stem cell migration and differentiation during neurodegenerative conditions in AD.

  12. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.

    Science.gov (United States)

    Callahan, D G; Taylor, W M; Tilearcio, M; Cavanaugh, T; Selkoe, D J; Young-Pearse, T L

    2017-03-08

    It is widely accepted that amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's disease. In addition, APP has been proposed to have functions in numerous biological processes including neuronal proliferation, differentiation, migration, axon guidance, and neurite outgrowth, as well as in synapse formation and function. However, germline knockout of APP yields relatively subtle phenotypes, and brain development appears grossly normal. This is thought to be due in part to functional compensation by APP family members and other type I transmembrane proteins. Here, we have generated a conditional mouse knockout for APP that is controlled temporally using Cre(ER) and tamoxifen administration. We show that total cortical expression of APP is reduced following tamoxifen administration during embryonic time points critical for cortical lamination, and that this results in displacement of Reelin-positive cells below the cortical plate with a concurrent elevation in Reelin protein levels. These results support a role for APP in cortical lamination and demonstrate the utility of a conditional knockout approach in which APP can be deleted with temporal control in vivo. This new tool should be useful for many different applications in the study of APP function across the mammalian life span.

  13. Putting education in "educational" apps: lessons from the science of learning.

    Science.gov (United States)

    Hirsh-Pasek, Kathy; Zosh, Jennifer M; Golinkoff, Roberta Michnick; Gray, James H; Robb, Michael B; Kaufman, Jordy

    2015-05-01

    Children are in the midst of a vast, unplanned experiment, surrounded by digital technologies that were not available but 5 years ago. At the apex of this boom is the introduction of applications ("apps") for tablets and smartphones. However, there is simply not the time, money, or resources available to evaluate each app as it enters the market. Thus, "educational" apps-the number of which, as of January 2015, stood at 80,000 in Apple's App Store (Apple, 2015)-are largely unregulated and untested. This article offers a way to define the potential educational impact of current and future apps. We build upon decades of work on the Science of Learning, which has examined how children learn best. From this work, we abstract a set of principles for two ultimate goals. First, we aim to guide researchers, educators, and designers in evidence-based app development. Second, by creating an evidence-based guide, we hope to set a new standard for evaluating and selecting the most effective existing children's apps. In short, we will show how the design and use of educational apps aligns with known processes of children's learning and development and offer a framework that can be used by parents and designers alike. Apps designed to promote active, engaged, meaningful, and socially interactive learning-four "pillars" of learning-within the context of a supported learning goal are considered educational.

  14. Office 2010 Web Apps For Dummies

    CERN Document Server

    Weverka, Peter

    2010-01-01

    Enhance your Microsoft Office 2010 experience with Office 2010 Web Apps!. Office Web Apps complement Office, making it easy to access and edit files from anywhere. It also simplifies collaboration with those who don't have Microsoft Office on their computers. This helpful book shows you the optimum ways you can use Office Web Apps to save time and streamline your work. Veteran For Dummies author Peter Weverka begins with an introduction to Office Web Apps and then goes on to clearly explain how Office Web Apps provide you with easier, faster, more flexible ways to get things done.: Walks you t

  15. A Framework for Mobile Apps in Colleges and Universities: Data Mining Perspective

    Science.gov (United States)

    Singh, Archana; Ranjan, Jayanthi

    2016-01-01

    The Enterprise mobility communication technology provides easy and quick accessibility to data and information integrated into one single touch point device. This device incorporates or integrates all the processes into small applications or App and thus increases the workforce capability of knowledge workers. "App" which is a small set…

  16. Developing Smartphone Apps for Education, Outreach, Science, and Engineering

    Science.gov (United States)

    Weatherwax, A. T.; Fitzsimmons, Z.; Czajkowski, J.; Breimer, E.; Hellman, S. B.; Hunter, S.; Dematteo, J.; Savery, T.; Melsert, K.; Sneeringer, J.

    2010-12-01

    The increased popularity of mobile phone apps provide scientists with a new avenue for sharing and distributing data and knowledge with colleagues, while also providing meaningful education and outreach products for consumption by the general public. Our initial development of iPhone and Android apps centered on the distribution of exciting auroral images taken at the South Pole for education and outreach purposes. These portable platforms, with limited resources when compared to computers, presented a unique set of design and implementation challenges that we will discuss in this presentation. For example, the design must account for limited memory; screen size; processing power; battery life; and potentially high data transport costs. Some of these unique requirements created an environment that enabled undergraduate and high-school students to participate in the creation of these apps. Additionally, during development it became apparent that these apps could also serve as data analysis and engineering tools. Our presentation will further discuss our plans to use apps not only for Education and Public Outreach, but for teaching, science and engineering.

  17. Functional Roles of the Interaction of APP and Lipoprotein Receptors

    Science.gov (United States)

    Pohlkamp, Theresa; Wasser, Catherine R.; Herz, Joachim

    2017-01-01

    The biological fates of the key initiator of Alzheimer’s disease (AD), the amyloid precursor protein (APP), and a family of lipoprotein receptors, the low-density lipoprotein (LDL) receptor-related proteins (LRPs) and their molecular roles in the neurodegenerative disease process are inseparably interwoven. Not only does APP bind tightly to the extracellular domains (ECDs) of several members of the LRP group, their intracellular portions are also connected through scaffolds like the one established by FE65 proteins and through interactions with adaptor proteins such as X11/Mint and Dab1. Moreover, the ECDs of APP and LRPs share common ligands, most notably Reelin, a regulator of neuronal migration during embryonic development and modulator of synaptic transmission in the adult brain, and Agrin, another signaling protein which is essential for the formation and maintenance of the neuromuscular junction (NMJ) and which likely also has critical, though at this time less well defined, roles for the regulation of central synapses. Furthermore, the major independent risk factors for AD, Apolipoprotein (Apo) E and ApoJ/Clusterin, are lipoprotein ligands for LRPs. Receptors and ligands mutually influence their intracellular trafficking and thereby the functions and abilities of neurons and the blood-brain-barrier to turn over and remove the pathological product of APP, the amyloid-β peptide. This article will review and summarize the molecular mechanisms that are shared by APP and LRPs and discuss their relative contributions to AD.

  18. [The inhibitor of free radical processes decrease of protein biosynthesis in gun short wound tissues and weaken development of the general adaptation syndrome].

    Science.gov (United States)

    Todorov, I N; Bogdanov, G N; Mitrokhin, Iu I; Varfolomeev, V N; Sidorenko, L I; Mishchenko, D V

    2006-01-01

    The dynamics of total protein biosynthesis and procollagen biosynthesis in skeletal muscle of injury tissues with the antioxidant BHT (dibunol) treatment and with common healing were studied. The obtained date indicate that the AO treatment reduce the rate of biosynthesis both the total proteins and procollagen at the 3th day of healing. Dibunol also considerably reduce the protein biosynthesis in adrenals and brake of corticosteroids biogenesis as measured by ESR-signals intensity of reduced adrenodoxine. AO treatment also reduce the protein biosynthesis in thymus, spleen and bone marrow. The lowering of functional activity of endocrine and immune systems indicate that the AO significantly inhibit the systemic reactions of organism induced by acute wound affect. It was suggested that as "primary mediator" of stress-reaction may be considered lipoperoxide radicals and decay products of lipohydroperoide.

  19. [Future trend medical apps. From the apps store directly into medical practice?].

    Science.gov (United States)

    Gehring, H; Pramann, O; Imhoff, M; Albrecht, U-V

    2014-12-01

    In day to day medical care, patients, nursing staff and doctors currently face a bewildering and rapidly growing number of health-related apps running on various "smart" devices and there are also uncountable possibilities for the use of such technology. Concerning regulation, a risk-based approach is applied for development and use (including safety and security considerations) of medical and health-related apps. Considering safety-related issues as well as organizational matters, this is a sensible approach but requires honest self-assessment as well as a high degree of responsibility, networking and good quality management by all those involved. This cannot be taken for granted. Apart from regulatory aspects it is important to not only consider what is reasonable, helpful or profitable. Quality aspects, safety matters, data protection and privacy as well as liability issues must also be considered but are often not adequately respected. If software quality is compromised, this endangers patient safety as well as data protection, privacy and data integrity. This can for example result in unwanted advertising or unauthorized access to the stored data by third parties; therefore, local, regional and international regulatory measures need to be applied in order to ensure safe use of medical apps in all possible areas, including the operating room (OR) with its highly specialized demands. Lawmakers need to include impulses from all stakeholders in their considerations and this should include input from existing private initiatives that already deal with the use and evaluation of apps in a medical context. Of course, this process needs to respect pre-existing national, European as well as international (harmonized) standards.

  20. Apps of Steel: Are Exercise Apps Providing Consumers with Realistic Expectations?: A Content Analysis of Exercise Apps for Presence of Behavior Change Theory

    Science.gov (United States)

    Cowan, Logan T.; Van Wagenen, Sarah A.; Brown, Brittany A.; Hedin, Riley J.; Seino-Stephan, Yukiko; Hall, P. Cougar; West, Joshua H.

    2013-01-01

    Objective. To quantify the presence of health behavior theory constructs in iPhone apps targeting physical activity. Methods. This study used a content analysis of 127 apps from Apple's (App Store) "Health & Fitness" category. Coders downloaded the apps and then used an established theory-based instrument to rate each app's inclusion of…

  1. Learning iPhone Programming From Xcode to App Store

    CERN Document Server

    Allan, Alasdair

    2010-01-01

    Get the hands-on experience you need to program for the iPhone and iPod Touch. With this easy-to-follow guide, you'll build several sample applications by learning how to use Xcode tools, the Objective-C programming language, and the core frameworks. Before you know it, you'll not only have the skills to develop your own apps, you'll know how to sail through the process of submitting apps to the iTunes App Store. Whether you're a developer new to Mac programming or an experienced Mac developer ready to tackle the iPhone and iPod Touch, Learning iPhone Programming will give you a head start o

  2. Learning System Center App Controller

    CERN Document Server

    Naeem, Nasir

    2015-01-01

    This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

  3. Popular Nutrition-Related Mobile Apps: A Feature Assessment

    Science.gov (United States)

    Fallaize, Rosalind; Lovegrove, Julie A; Hwang, Faustina

    2016-01-01

    predominantly on energy balance between dietary intake and PA. None of these nine apps offered features directly related to diet plans and motivational coaching. In contrast, the remaining four of the 13 apps focused on these opportunities, but without food diaries. One app—FatSecret—also had an innovative feature for connecting users with health professionals, and another—S Health—provided a nutrient balance score. Conclusions The high number of installs indicates that there is a clear interest and opportunity for diet monitoring and recommendation using mobile apps. All the apps collecting dietary intake used the same nutrition assessment method (ie, food diary record) and technologies for data input (ie, text search and barcode scanner). Emerging technologies, such as image recognition, natural language processing, and artificial intelligence, were not identified. None of the apps had a decision engine capable of providing personalized diet advice. PMID:27480144

  4. 基于移动用户体验的 APP 设计%The Exploration of APP Design based on Mobile User Experience

    Institute of Scientific and Technical Information of China (English)

    陆远蓉

    2014-01-01

    未来的互联网将是以移动网络链接为主的移动互联网,APP 作为移动设备功能的扩展,受到越来越多用户的关注,移动互联网有 APP 化的趋势。从日常产品的用户体验案例分析 APP 设计中用户体验的必要性,说明用户体验、尤其是移动用户体验成为 APP 的竞争软实力,成为衡量产品成功与否的一项指标,也是助力在激烈 APP 市场竞争、趋同的企业间技术突围而出的要素之一。%The future Internet would be the mobile one centerd round mobile network link.There is growing concern about APP,which is taken as the extension to mobile device capabilities,and simultaneously mobile network shows the tendency of APP state.The paper gets help from user experience case of everyday products to analyze the necessity of user experience in the process of APP design,and proves user experience ,especially mobile user experience,has become the competition soft power of APP.Moreover,the mobile user experience is an indicator to judge the success or not of a product,and is al-so one of the elements to gain its predominance in the fierce market competition of APP,as well as under the background of technological convergence between enterprises.

  5. An Android Communication App Forensic Taxonomy.

    Science.gov (United States)

    Azfar, Abdullah; Choo, Kim-Kwang Raymond; Liu, Lin

    2016-09-01

    Due to the popularity of Android devices and applications (apps), Android forensics is one of the most studied topics within mobile forensics. Communication apps, such as instant messaging and Voice over IP (VoIP), are one popular app category used by mobile device users, including criminals. Therefore, a taxonomy outlining artifacts of forensic interest involving the use of Android communication apps will facilitate the timely collection and analysis of evidentiary materials from such apps. In this paper, 30 popular Android communication apps were examined, where a logical extraction of the Android phone images was collected using XRY, a widely used mobile forensic tool. Various information of forensic interest, such as contact lists and chronology of messages, was recovered. Based on the findings, a two-dimensional taxonomy of the forensic artifacts of the communication apps is proposed, with the app categories in one dimension and the classes of artifacts in the other dimension. Finally, the artifacts identified in the study of the 30 communication apps are summarized using the taxonomy. It is expected that the proposed taxonomy and the forensic findings in this paper will assist forensic investigations involving Android communication apps.

  6. Towards Better Understanding of App Functions

    Institute of Scientific and Technical Information of China (English)

    童永昕; 余洁莹; 陈雷

    2015-01-01

    Apps are attracting more and more attention from both mobile and web platforms. Due to the self-organized nature of the current app marketplaces, the descriptions of apps are not formally written and contain a lot of noisy words and sentences. Thus, for most of the apps, the functions of them are not well documented and thus cannot be captured by app search engines easily. In this paper, we study the problem of inferring the real functions of an app by identifying the most informative words in its description. In order to utilize and integrate the diverse information of the app corpus in a proper way, we propose a probabilistic topic model to discover the latent data structure of the app corpus. The outputs of the topic model are further used to identify the function of an app and its most informative words. We verify the effectiveness of the proposed methods through extensive experiments on two real app datasets crawled from Google Play and Windows Phone Store, respectively.

  7. Content Analysis of Diet-Related Mobile Apps: A Self-Regulation Perspective.

    Science.gov (United States)

    Zahry, Nagwan R; Cheng, Ying; Peng, Wei

    2016-10-01

    Diet-related mobile apps hold promise in helping individuals self-regulate their eating behaviors. Nevertheless, little is known about the extent to which diet-related mobile apps incorporate the established behavior change theories and evidence-based practices that promote dietary self-regulation. Guided by the self-regulation aspect of Bandura's social cognitive theory and the Dietary Guidelines for Americans 2010 of the U.S. Department of Agriculture, this study conducts a content analysis of diet-related mobile apps for iPhone (N = 400). In terms of the adherence to the self-regulation aspect of the social cognitive theory, results show that although 72.5% of the apps incorporate at least one theoretical construct, few apps tap all three processes of self-regulation (i.e., self-observation/monitoring, judgment process, and self-reaction). Additionally, outcome expectation is manifested in a majority of the diet-related apps. In terms of the Dietary Guidelines for Americans 2010, while the diet-related apps equally emphasize setting goals for calorie intake or nutrient consumption, more apps feature nutrient tracking than calorie tracking. Implications and limitations are discussed.

  8. Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N

    DEFF Research Database (Denmark)

    Danielsen, E M; Cowell, G M; Norén, Ove

    1983-01-01

    The post-translational processing of pig small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured mucosal explants. Exposure of the explants to swainsonine, an inhibitor of Golgi mannosidase II, resulted in the formation of a Mr-160000 polypeptide, still sensitive to endo...... for the transport of aminopeptidase N to its final destination. A different type of processing was observed to take place in the presence of swainsonine, resulting in a considerable increase in apparent Mr (from 140000 to 160000). This processing could not be ascribed to N-linked glycosylation, since treatment...

  9. Windows 8 app projects XAML and C#

    CERN Document Server

    Vermeir, Nico

    2013-01-01

    Become a leading Windows 8 app developer by using Windows 8 App Projects - XAML and C# Edition to learn techniques, tools, and ideas to create successful, 5-star apps. Windows 8 App Projects - XAML and C# Edition shows you the nuts and bolts of the Windows 8 development ecosystem. Then, through a series of example driven chapters, you'll discover how to leverage the platform's unique features. With each project, you'll be one step closer to building full-featured, responsive, and well designed apps that feel like they're a part of the operating system. Windows 8 App Projects - XAML and C# Edit

  10. Smartphone app design for the wireless control of a neuromuscular electrical stimulator device with integrated randomization allocation process for RCT applications.

    Science.gov (United States)

    Sweeney, Dean; Quinlan, Leo R; OLaighin, Gearoid

    2015-08-01

    The use of NMES has evolved over the last five decades. Technological advancements have transformed these once complex systems into user-friendly devices with enhanced control functions, leading to new applications of NMES being investigated. The use of Randomized Control Trial (RCT) methodology in evaluating the effectiveness of new and existing applications of NMES is a demanding process adding time and cost to a translation into clinical practice. Poor quality trials may result in poor evidence of NMES effectiveness. In this paper some of the key challenges encountered in NMES clinical trials are identified with the aim of purposing a solution to address these challenges through the adoption of Smartphone technology. The design and evaluation of a smartphone application to provide automatic blind randomization control and facilitating the wireless temporal control of a portable Bluetooth enabled NMES is presented.

  11. Learning by Doing: How to Develop a Cross-Platform Web App

    Directory of Open Access Journals (Sweden)

    Minh Q. Huynh

    2015-06-01

    Full Text Available As mobile devices become prevalent, there is always a need for apps.  How hard is it to develop an app especially a cross-platform app? The paper shares an experience in a project involved the development of a student services web app that can be run on cross-platform mobile devices.  The paper first describes the background of the project, the clients, and the proposed solution.  Then, it focuses on the step-by-step development processes and provides the illustration of written codes and techniques used.  The goal is for readers to gain an understanding on how to develop a mobile-friendly web app.  The paper concludes with teaching implications and offers thoughts for further development.

  12. Hypnosis--there's an app for that: a systematic review of hypnosis apps.

    Science.gov (United States)

    Sucala, Madalina; Schnur, Julie B; Glazier, Kimberly; Miller, Sarah J; Green, Joseph P; Montgomery, Guy H

    2013-01-01

    This study systematically reviews the hypnosis apps available via iTunes that were compatible with iPhone or iPad. Of 1455 apps identified on iTunes, 407 met inclusion criteria and were further reviewed. Most common hypnosis app targets were weight loss (23%), boosting self-esteem (20%), and relaxation/stress reduction (19%); 83% of apps delivered hypnosis via audio track, and 37% allowed tailoring. Less than 14% of apps reported disclaimers. None of the apps reported having been tested for efficacy, and none reported being evidence based. Although apps have the potential to enhance hypnosis delivery, it seems as though technology has raced ahead of the supporting science. Recommendations from clinical researchers and policy makers are needed to inform responsible hypnosis app development and use.

  13. APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.

    Science.gov (United States)

    Stanga, Serena; Zanou, Nadège; Audouard, Emilie; Tasiaux, Bernadette; Contino, Sabrina; Vandermeulen, Gaëlle; René, Frédérique; Loeffler, Jean-Philippe; Clotman, Frédéric; Gailly, Philippe; Dewachter, Ilse; Octave, Jean-Noël; Kienlen-Campard, Pascal

    2016-05-01

    Besides its crucial role in the pathogenesis of Alzheimer's disease, the knowledge of amyloid precursor protein (APP) physiologic functions remains surprisingly scarce. Here, we show that APP regulates the transcription of the glial cell line-derived neurotrophic factor (GDNF). APP-dependent regulation of GDNF expression affects muscle strength, muscular trophy, and both neuronal and muscular differentiation fundamental for neuromuscular junction (NMJ) maturation in vivo In a nerve-muscle coculture model set up to modelize NMJ formation in vitro, silencing of muscular APP induces a 30% decrease in secreted GDNF levels and a 40% decrease in the total number of NMJs together with a significant reduction in the density of acetylcholine vesicles at the presynaptic site and in neuronal maturation. These defects are rescued by GDNF expression in muscle cells in the conditions where muscular APP has been previously silenced. Expression of GDNF in muscles of amyloid precursor protein null mice corrected the aberrant synaptic morphology of NMJs. Our findings highlight for the first time that APP-dependent GDNF expression drives the process of NMJ formation, providing new insights into the link between APP gene regulatory network and physiologic functions.-Stanga, S., Zanou, N., Audouard, E., Tasiaux, B., Contino, S., Vandermeulen, G., René, F., Loeffler, J.-P., Clotman, F., Gailly, P., Dewachter, I., Octave, J.-N., Kienlen-Campard, P. APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.

  14. CSS for Windows 8 app development

    CERN Document Server

    Foster, Jeremy

    2013-01-01

    CSS for Windows 8 App Development is your learning guide for CSS - the language of great Windows 8-style apps. Learn the built-in styles that make the built-in controls shine, how to define them, and how to use CSS to give your custom app assets that beautiful Modern UI style. CSS (Cascading Style Sheets) is the clear standard for styling web applications, and with HTML, CSS, and JavaScript now powering apps on Windows 8, it's the clear standard there as well. CSS is a powerful styling and layout language that greatly simplifies the selection of page elements and their visual display, layout,

  15. Building Web Apps for Google TV

    CERN Document Server

    Ferrate, Andres; Lee, Daniels; Ohye, Maile; Carff, Paul; Shen, Shawn; Hines, Steven

    2011-01-01

    By integrating the Web with traditional TV, Google TV offers developers an important new channel for content. But creating apps for Google TV requires learning some new skills-in fact, what you may already know about mobile or desktop web apps isn't entirely applicable. Building Web Apps for Google TV will help you make the transition to Google TV as you learn the tools and techniques necessary to build sophisticated web apps for this platform. This book shows you how Google TV works, how it fits into the web ecosystem, and what the opportunities are for delivering rich content to millions o

  16. Redefining Cheminformatics with Intuitive Collaborative Mobile Apps.

    Science.gov (United States)

    Clark, Alex M; Ekins, Sean; Williams, Antony J

    2012-08-01

    The proliferation of mobile devices such as smartphones and tablet computers has recently been extended to include a growing ecosystem of increasingly sophisticated chemistry software packages, commonly known as apps. The capabilities that these apps can offer to the practicing chemist are approaching those of conventional desktop-based software, but apps tend to be focused on a relatively small range of tasks. To overcome this, chemistry apps must be able to seamlessly transfer data to other apps, and through the network to other devices, as well as to other platforms, such as desktops and servers, using documented file formats and protocols whenever possible. This article describes the development and state of the art with regard to chemistry-aware apps that make use of facile data interchange, and some of the scenarios in which these apps can be inserted into a chemical information workflow to increase productivity. A selection of contemporary apps is used to demonstrate their relevance to pharmaceutical research. Mobile apps represent a novel approach for delivery of cheminformatics tools to chemists and other scientists, and indications suggest that mobile devices represent a disruptive technology for drug discovery, as they have been to many other industries.

  17. APP Causes Hyperexcitability in Fragile X Mice

    Science.gov (United States)

    Westmark, Cara J.; Chuang, Shih-Chieh; Hays, Seth A.; Filon, Mikolaj J.; Ray, Brian C.; Westmark, Pamela R.; Gibson, Jay R.; Huber, Kimberly M.; Wong, Robert K. S.

    2016-01-01

    Amyloid-beta protein precursor (APP) and metabolite levels are altered in fragile X syndrome (FXS) patients and in the mouse model of the disorder, Fmr1KO mice. Normalization of APP levels in Fmr1KO mice (Fmr1KO/APPHET mice) rescues many disease phenotypes. Thus, APP is a potential biomarker as well as therapeutic target for FXS. Hyperexcitability is a key phenotype of FXS. Herein, we determine the effects of APP levels on hyperexcitability in Fmr1KO brain slices. Fmr1KO/APPHET slices exhibit complete rescue of UP states in a neocortical hyperexcitability model and reduced duration of ictal discharges in a CA3 hippocampal model. These data demonstrate that APP plays a pivotal role in maintaining an appropriate balance of excitation and inhibition (E/I) in neural circuits. A model is proposed whereby APP acts as a rheostat in a molecular circuit that modulates hyperexcitability through mGluR5 and FMRP. Both over- and under-expression of APP in the context of the Fmr1KO increases seizure propensity suggesting that an APP rheostat maintains appropriate E/I levels but is overloaded by mGluR5-mediated excitation in the absence of FMRP. These findings are discussed in relation to novel treatment approaches to restore APP homeostasis in FXS. PMID:28018172

  18. Apps for Radiation Oncology. A Comprehensive Review

    Directory of Open Access Journals (Sweden)

    J.J. Calero

    2017-02-01

    Full Text Available Introduction: Software applications executed on a smart-phone or mobile device (“Apps” are increasingly used by oncologists in their daily work. A comprehensive critical review was conducted on Apps specifically designed for Radiation Oncology, which aims to provide scientific support for these tools and to guide users in choosing the most suited to their needs. Material and methods: A systematic search was conducted in mobile platforms, iOS and Android, returning 157 Apps. Excluding those whose purpose did not match the scope of the study, 31 Apps were methodically analyzed by the following items: Objective Features, List of Functionalities, Consistency in Outcomes and Usability. Results: Apps are presented in groups of features, as Dose Calculators (7 Apps, Clinical Calculators (4, Tools for Staging (7, Multipurpose (7 and Others (6. Each App is presented with the list of attributes and a brief comment. A short summary is provided at the end of each group. Discussion and Recommendations: There are numerous Apps with useful tools at the disposal of radiation oncologists. The most advisable Apps do not match the more expensive. Three all-in-one apps seem advisable above all: RadOnc Reference (in English, Easy Oncology (in German and iOncoR (in Spanish. Others recommendations are suggested for specific tasks: dose calculators, treatment-decision and staging.

  19. Mobile App Rating Scale: A New Tool for Assessing the Quality of Health Mobile Apps

    OpenAIRE

    Stoyanov, Stoyan R.; Hides, Leanne; Kavanagh, David John; Zelenko, Oksana; Tjondronegoro, Dian; Mani, Madhavan

    2015-01-01

    Background The use of mobile apps for health and well being promotion has grown exponentially in recent years. Yet, there is currently no app-quality assessment tool beyond “star”-ratings. Objective The objective of this study was to develop a reliable, multidimensional measure for trialling, classifying, and rating the quality of mobile health apps. Methods A literature search was conducted to identify articles containing explicit Web or app quality rating criteria published between January ...

  20. E 社区 APP 设计与开发:体验智能现代社区生活%The APP Design and Development of E Community--Intelligent Modern Community Life Experience

    Institute of Scientific and Technical Information of China (English)

    杨建迪; 黄岚

    2015-01-01

    When the smartphone applications hit among industry, mobile phone APP has entered people's lives every corner. Message clear and concise, convenient interactive way and let the community property APP also ushered in a new growth point. Today, people can never leave home to understand the surrounding commercial information, enjoy the phone APP brings the intelligent way of life. Based on the practical experience in the development community APP process to the function of community type of APP, advantages and disadvantages, and elaborates the development and analysis.%当智能手机应用风靡各个行业时,手机 APP 也随之走进了人们生活的每一个角落。信息传递简洁明了,互动方式灵活方便,让物业社区 APP 也迎来了一个新的增长点。如今,居民可以足不出户了解周边的商业信息,享受手机 APP 带来的智能化生活方式。本文通过在开发社区 APP 过程中的实际经历对社区类 APP 的功能、优缺点及发展状况进行阐述和分析。

  1. ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity

    Directory of Open Access Journals (Sweden)

    Bu Guojun

    2007-07-01

    Full Text Available Abstract Background The generation of the amyloid-β peptide (Aβ through the proteolytic processing of the amyloid precursor protein (APP is a central event in the pathogenesis of Alzheimer's disease (AD. Recent studies highlight APP endocytosis and localization to lipid rafts as important events favoring amyloidogenic processing. However, the precise mechanisms underlying these events are poorly understood. ApoER2 is a member of the low density lipoprotein receptor (LDL-R family exhibiting slow endocytosis rate and a significant association with lipid rafts. Despite the important neurophysiological roles described for ApoER2, little is known regarding how ApoER2 regulates APP trafficking and processing. Results Here, we demonstrate that ApoER2 physically interacts and co-localizes with APP. Remarkably, we found that ApoER2 increases cell surface APP levels and APP association with lipid rafts. The increase of cell surface APP requires the presence of ApoER2 cytoplasmic domain and is a result of decreased APP internalization rate. Unexpectedly, ApoER2 expression correlated with a significant increase in Aβ production and reduced levels of APP-CTFs. The increased Aβ production was dependent on the integrity of the NPxY endocytosis motif of ApoER2. We also found that expression of ApoER2 increased APP association with lipid rafts and increased γ-secretase activity, both of which might contribute to increased Aβ production. Conclusion These findings show that ApoER2 negatively affects APP internalization. However, ApoER2 expression stimulates Aβ production by shifting the proportion of APP from the non-rafts to the raft membrane domains, thereby promoting β-secretase and γ-secretase mediated amyloidogenic processing and also by incrementing the activity of γ-secretase.

  2. A Guide to Help Consumers Choose Apps and Avoid App Overload

    Science.gov (United States)

    Schuster, Ellen; Zimmerman, Lynda

    2014-01-01

    Mobile technology has transformed the way consumers access and use information. The exponential growth of mobile apps makes finding suitable, easy-to-use nutrition and health-related apps challenging. A guide for consumers helps them ask important questions before downloading apps. The guide can be adapted for other Extension disciplines.

  3. Y682 mutation of amyloid precursor protein promotes endo-lysosomal dysfunction by disrupting APP-SorLA interaction

    Directory of Open Access Journals (Sweden)

    Luca Rosario La Rosa

    2015-04-01

    Full Text Available The intracellular transport and localization of amyloid precursor protein (APP are critical determinants of APP processing and β-amyloid peptide production, thus crucially important for the pathophysiology of Alzheimer’s disease (AD. Notably, the C-terminal Y682ENPTY687 domain of APP binds to specific adaptors controlling APP trafficking and sorting in neurons. Mutation on the Y682 residue to glycine (Y682G leads to altered APP sorting in hippocampal neurons that favors its accumulation in intracellular compartments and the release of soluble APPα. Such alterations induce premature aging and learning and cognitive deficits in APP Y682G mutant mice (APPYG/YG. Here, we report that Y682G mutation affects formation of the APP complex with sortilin-related receptor (SorLA, resulting in endo-lysosomal dysfunctions and neuronal degeneration. Moreover, disruption of the APP/SorLA complex changes the trafficking pathway of SorLA, with its consequent increase in secretion outside neurons. Mutations in the SorLA gene are a prognostic factor in AD, and increases in SorLA levels in cerebrospinal fluid are predictive of AD in humans. These results might open new possibilities in comprehending the role played by SorLA in its interaction with APP and in the progression of neuronal degeneration. In addition, they further underline the crucial role played by Y682 residue in controlling APP trafficking in neurons.

  4. ADDITIONAL STREET BERBASIS APP INVENTOR

    Directory of Open Access Journals (Sweden)

    Mohammad Adib Adhi Prabowo

    2013-05-01

    Full Text Available Abstrak Seiring dengan perkembangan sistem operasi android, telah banyak aplikasi yang memanfaatkan fasilitas GPS dan Google Map, seperti untuk mencari rute, mendapatkan peta, mencari lokasi tertentu pada sebuah tempat. Akan tetapi seringkali pengguna perangkat bergerak kesulitan ketika ingin mengetahui beberapa tempat dan lokasi tertentu karena belum ada fasilitas yang menyediakan informasi lokasi suatu tempat. Walaupun ada informasi lokasi pada peta biasanya informasi yang diberikan lokasi tempat berskala besar, misalnya lokasi tempat wisata atau stasiun kereta api. Pengembangan aplikasi untuk skala kecil ini akan memberikan informasi yang dipresentasikan pada google map. Selama ini belum ada yang memberikan sebuah informasi lokasi tempat penting yang berskala kecil. Misalnya informasi lokasi  tambal ban, lokasi warung makan, lokasi laundry, dan lokasi bengkel motor. Oleh karena itu kami mencoba untuk mengembangkan aplikasi additional street berbasis android via App Inventor dengan bantuan google maps. Aplikasi additional street ini dapat memberikan informasi letak objek pada peta serta memberikan informasi jalan menuju lokasi tersebut dan detail informasi lokasi tersebut serta lokasi dari pengguna aplikasi tersebut. Kata Kunci: additional street, android, google maps, app inventor, GPS

  5. Detecting android malicious apps and categorizing benign apps with ensemble of classifiers

    KAUST Repository

    Wang, Wei

    2017-01-17

    Android platform has dominated the markets of smart mobile devices in recent years. The number of Android applications (apps) has seen a massive surge. Unsurprisingly, Android platform has also become the primary target of attackers. The management of the explosively expansive app markets has thus become an important issue. On the one hand, it requires effectively detecting malicious applications (malapps) in order to keep the malapps out of the app market. On the other hand, it needs to automatically categorize a big number of benign apps so as to ease the management, such as correcting an app’s category falsely designated by the app developer. In this work, we propose a framework to effectively and efficiently manage a big app market in terms of detecting malapps and categorizing benign apps. We extract 11 types of static features from each app to characterize the behaviors of the app, and employ the ensemble of multiple classifiers, namely, Support Vector Machine (SVM), K-Nearest Neighbor (KNN), Naive Bayes (NB), Classification and Regression Tree (CART) and Random Forest (RF), to detect malapps and to categorize benign apps. An alarm will be triggered if an app is identified as malicious. Otherwise, the benign app will be identified as a specific category. We evaluate the framework on a large app set consisting of 107,327 benign apps as well as 8,701 malapps. The experimental results show that our method achieves the accuracy of 99.39% in the detection of malapps and achieves the best accuracy of 82.93% in the categorization of benign apps.

  6. Security, Privacy Awareness vs. Utilization of Social Networks and Mobile Apps for Learning: Students` Preparedness

    Directory of Open Access Journals (Sweden)

    Daniel Koloseni

    Full Text Available The application of social networks and mobile apps for learning can improve learning process drastically in Higher learning Institutions as it offers tools and capabilities that creates flexible and convenient learning environment. But the utilization of ...

  7. Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.

    Science.gov (United States)

    Sobol, Anna; Galluzzo, Paola; Liang, Shuang; Rambo, Brittany; Skucha, Sylvia; Weber, Megan J; Alani, Sara; Bocchetta, Maurizio

    2015-05-01

    Hypoxic non-small cell lung cancer (NSCLC) is dependent on Notch-1 signaling for survival. Targeting Notch-1 by means of γ-secretase inhibitors (GSI) proved effective in killing hypoxic NSCLC. Post-mortem analysis of GSI-treated, NSCLC-burdened mice suggested enhanced phosphorylation of 4E-BP1 at threonines 37/46 in hypoxic tumor tissues. In vitro dissection of this phenomenon revealed that Amyloid Precursor Protein (APP) inhibition was responsible for a non-canonical 4E-BP1 phosphorylation pattern rearrangement-a process, in part, mediated by APP regulation of the pseudophosphatase Styx. Upon APP depletion we observed modifications of eIF-4F composition indicating increased recruitment of eIF-4A to the mRNA cap. This phenomenon was supported by the observation that cells with depleted APP were partially resistant to silvestrol, an antibiotic that interferes with eIF-4A assembly into eIF-4F complexes. APP downregulation in dividing human cells increased the rate of global protein synthesis, both cap- and IRES-dependent. Such an increase seemed independent of mTOR inhibition. After administration of Torin-1, APP downregulation and Mechanistic Target of Rapamycin Complex 1 (mTORC-1) inhibition affected 4E-BP1 phosphorylation and global protein synthesis in opposite fashions. Additional investigations indicated that APP operates independently of mTORC-1. Key phenomena described in this study were reversed by overexpression of the APP C-terminal domain. The presented data suggest that APP may be a novel regulator of protein synthesis in dividing human cells, both cancerous and primary. Furthermore, APP appears to affect translation initiation using mechanisms seemingly dissimilar to mTORC-1 regulation of cap-dependent protein synthesis.

  8. Tree Height Calculator: An Android App for Estimating Tree Height

    Science.gov (United States)

    Burca, V. S.; Htet, N. M.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.

    2011-12-01

    Conventionally, measuring tree height requires a collection of different tools - clinometer, transit, pencil, paper, laptop computer. Results are recorded manually and entered into a spreadsheet or database for future calculation and analysis. Tree Height Calculator is a mobile Android app the integrates the various steps in this process thereby improving the accuracy and dramatically reducing the time required to go from taking measurements to analyzing data. Given the user's height and the distance from the base of the tree (which can be downloaded into the app from a server), the app uses the phone's orientation sensor to calculate the angle of elevation. A simple trigonometric formula is then used to calculate and record the tree's height in the phone's database. When the phone has a WiFi connection, the data are transmitted to a server, from where they can be downloaded directly into a spreadsheet. The application was first tested in an Environmental Science laboratory at Trinity College. On the first trial, 103 data samples were collected, stored, and uploaded to the online database with only couple of dropped data points. On the second trial, 98 data samples were gathered with no loss of data. The app combined the individual measurements taken by the students in the lab, reducing the time required to produce a graph of the class's results from days to hours.

  9. MyShake - A smartphone app to detect earthquake

    Science.gov (United States)

    Kong, Q.; Allen, R. M.; Schreier, L.; Kwon, Y. W.

    2015-12-01

    We designed an android app that harnesses the accelerometers in personal smartphones to record earthquake-shaking data for research, hazard information and warnings. The app has the function to distinguish earthquake shakings from daily human activities based on the different patterns behind the movements. It also can be triggered by the traditional earthquake early warning (EEW) system to record for a certain amount of time to collect earthquake data. When the app is triggered by the earthquake-like movements, it sends the trigger information back to our server which contains time and location of the trigger, at the same time, it stores the waveform data on local phone first, and upload to our server later. Trigger information from multiple phones will be processed in real time on the server to find the coherent signal to confirm the earthquakes. Therefore, the app provides the basis to form a smartphone seismic network that can detect earthquake and even provide warnings. A planned public roll-out of MyShake could collect millions of seismic recordings for large earthquakes in many regions around the world.

  10. Smartphone-apps som nyt psykiatrisk behandlingstiltag

    DEFF Research Database (Denmark)

    Dalum, Anette Ellegaard; Arnfred, Sidse

    2014-01-01

    The number of smartphone apps for people with mental health issues is undergoing a dramatical growth in these years. We review the available literature on the topic, discuss opportunities and theoretical considerations using smartphone apps in psychiatric treatment and provide an overview...

  11. Smartphone apps as a new psychiatric treatment

    DEFF Research Database (Denmark)

    Dalum, Anette Ellegaard; Arnfred, Sidse Marie

    2014-01-01

    Søg 1 - 1 ud af 1 Smartphone apps as a new psychiatric treatment. Anette Ellegaard Dalum, Sidse Arnfred, 2014, vol. 176, nummer 34, 2014. Ugeskrift for laeger Artikel Importer Fjern......Søg 1 - 1 ud af 1 Smartphone apps as a new psychiatric treatment. Anette Ellegaard Dalum, Sidse Arnfred, 2014, vol. 176, nummer 34, 2014. Ugeskrift for laeger Artikel Importer Fjern...

  12. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Falkesgaard Slot, Marie; Gissel, Stig Toke; Lorentzen, Rasmus Fink

    2013-01-01

    Artiklen udpeger en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analysere og vurdere hvilke handle- og betydningsmuligheder, der er indbygget i hhv. funktionelle, didaktiske og semantiske apps. Med afsæt i disse begreber gives praksisnære bud på, hvordan apps på for...

  13. The Electronic Discharge Letter Mobile App

    NARCIS (Netherlands)

    Lezcano, Leonardo; Ternier, Stefaan; Drachsler, Hendrik; Kalz, Marco; Specht, Marcus

    2013-01-01

    Lezcano, L., Ternier, S., Drachsler, H., Kalz, M., & Specht, M. (2013, September). The Electronic Discharge Letter Mobile App. In iProceedings of MEDICINE 2.0: 6th World Congress on Social Media, Mobile Apps, Internet/Web 2.0 (pp. 221-222). London, England. Retrieved from http://www.medicine20congre

  14. App Development Paradigms for Instructional Developers

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    To create instructional apps for desktop, laptop and mobile devices, developers must select a development tool. Tool selection is critical and complicated by the large number and variety of app development tools. One important criterion to consider is the type of development environment, which may primarily be visual or symbolic. Those distinct…

  15. Gebruikersdata bij abonnementen in app stores

    NARCIS (Netherlands)

    Roosendaal, A.P.C.; Nieuwenhuis, O.A.

    2013-01-01

    Kranten en tijdschriften bieden tegenwoordig vaak, naast de papieren edities, digitale abonnementen aan. De content wordt in dat geval via een app gelezen op een mobiele device, zoals een smartphone of tablet. Om abonnementen in deze vorm aan te kunnen bieden is het bouwen van een app noodzakelijk.

  16. Will HTML5 Kill the Native App?

    Science.gov (United States)

    Fredette, Michelle

    2013-01-01

    For colleges and universities today, the question is no longer whether to develop a campus app or not. Instead, the debate has shifted to the best--and most cost-efficient--way to make campus applications accessible to the myriad devices and operating systems out there. Schools have a few options: They can develop multiple native app versions;…

  17. Cool Apps: Productivity at Your Fingertips

    Science.gov (United States)

    Flaherty, Bill

    2013-01-01

    In addition to listing apps and their value, this article focuses on ways people can be more productive by adopting certain workflows in several ways. Apps listed herein include those useful in calendaring, printing, photo-editing, image-recognition, image scanning, electronic signatures, and making and sharing lists and notes.

  18. Apps and eating disorders: A systematic clinical appraisal

    OpenAIRE

    Fairburn, Christopher G; Rothwell, Emily R.

    2015-01-01

    ABSTRACT Objective Smartphone applications (apps) are proliferating and health‐related apps are particularly popular. The aim of this study was to identify, characterize, and evaluate the clinical utility of apps designed either for people with eating disorders or for eating disorder professionals. Method A search of the major app stores identified 805 potentially relevant apps, of which 39 were primarily designed for people with eating disorders and five for professionals. Results The apps f...

  19. Popular weight-management apps: Their use and quality

    Directory of Open Access Journals (Sweden)

    Juliana Chen

    2015-09-01

    Conclusions: While greater popularity of apps was associated with higher quality, the overall quality of commercial dietary weight-management apps remains suboptimal. Popular weight-management apps are useful for self-monitoring, however are lacking in the recognised behavioural change techniques that may facilitate changes in health behaviours. With the majority of these apps designed for self-directed management, strategies to improve the rigour of these apps are warranted and commercial app developers could benefit from collaboration with behavioural researchers.

  20. Forensic Taxonomy of Android Social Apps.

    Science.gov (United States)

    Azfar, Abdullah; Choo, Kim-Kwang Raymond; Liu, Lin

    2017-03-01

    An Android social app taxonomy incorporating artifacts that are of forensic interest will enable users and forensic investigators to identify the personally identifiable information (PII) stored by the apps. In this study, 30 popular Android social apps were examined. Artifacts of forensic interest (e.g., contacts lists, chronology of messages, and timestamp of an added contact) were recovered. In addition, images were located, and Facebook token strings used to tie account identities and gain access to information entered into Facebook by a user were identified. Based on the findings, a two-dimensional taxonomy of the forensic artifacts of the social apps is proposed. A comparative summary of existing forensic taxonomies of different categories of Android apps, designed to facilitate timely collection and analysis of evidentiary materials from Android devices, is presented.

  1. Best book on marketing your Android app

    CERN Document Server

    Kim, Eddie

    2012-01-01

    Bestselling Android Dev Eddie Kim Teaches You How To Market Your Android Apps! You've designed the perfect app, and you're wondering why no one is buying it. Our experienced Android developer, Eddie Kim, has been in your shoes, and he knows how stiff the competition can be. Eddie introduces you to the people with the power, your customers, as he walks you through the marketing steps you need to take to make your app stand out from the a sea of similar apps. You're an innovative developer, but when it comes to advertising your app, you don't know how to rally an audience like Billy May

  2. Smart apps for the smart plastic surgeon

    Directory of Open Access Journals (Sweden)

    Aniketh Venkataram

    2015-01-01

    Full Text Available Smartphones have the ability to benefit plastic surgeons in all aspects of patient care and education. With the sheer number of applications available and more being created everyday, it is easy to miss out on apps which could be of great relevance. Moreover, the range of android applications available has not been extensively discussed in the literature. To this end, we have compiled an exhaustive list of android smartphone applications, which we feel can help our day to day functioning. The apps have been extensively reviewed and neatly described along with all their potential uses. In addition, we have made an effort to highlight ′non-medical′ or efficiency apps which can improve departmental functioning. These apps have not been described in prior articles, and their functionality might not be known to all. We believe that the technology savvy plastic surgeon can make maximum use of these apps to his benefit.

  3. Cell biology apps for Apple devices.

    Science.gov (United States)

    Stark, Louisa A

    2012-01-01

    Apps for touch-pad devices hold promise for guiding and supporting learning. Students may use them in the classroom or on their own for didactic instruction, just-in-time learning, or review. Since Apple touch-pad devices (i.e., iPad and iPhone) have a substantial share of the touch-pad device market (Campbell, 2012), this Feature will explore cell biology apps available from the App Store. My review includes iPad and iPhone apps available in June 2012, but does not include courses, lectures, podcasts, audiobooks, texts, or other books. I rated each app on a five-point scale (1 star = lowest; 5 stars = highest) for educational and production values; I also provide an overall score.

  4. The business of iOS app development for iPhone, iPad and iPod Touch

    CERN Document Server

    Wooldridge, Dave

    2014-01-01

    Updated and expanded for the new Apple iOS8, The Business of iOS App Development, Third Edition shows you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of succeeding in the App Store. This book is written by experienced developers with business backgrounds, taking you step-by-step through cost-effective marketing techniques that have proven successful for professional iOS app creators-perfect for independent developers on shoestring budgets. No prior business knowledge is required. The pheno

  5. Oceanographic data at your fingertips: the SOCIB App for smartphones

    Science.gov (United States)

    Lora, Sebastian; Sebastian, Kristian; Troupin, Charles; Pau Beltran, Joan; Frontera, Biel; Gómara, Sonia; Tintoré, Joaquín

    2015-04-01

    The Balearic Islands Coastal Ocean Observing and Forecasting System (SOCIB, http://www.socib.es), is a multi-platform Marine Research Infrastructure that generates data from nearshore to the open sea in the Western Mediterranean Sea. In line with SOCIB principles of discoverable, freely available and standardized data, an application (App) for smartphones has been designed, with the objective of providing an easy access to all the data managed by SOCIB in real-time: underwater gliders, drifters, profiling buoys, research vessel, HF Radar and numerical model outputs (hydrodynamics and waves). The Data Centre, responsible for the aquisition, processing and visualisation of all SOCIB data, developed a REpresentational State Transfer (REST) application programming interface (API) called "DataDiscovery" (http://apps.socib.es/DataDiscovery/). This API is made up of RESTful web services that provide information on : platforms, instruments, deployments of instruments. It also provides the data themselves. In this way, it is possible to integrate SOCIB data in third-party applications, developed either by the Data Center or externally. The existence of a single point for the data distribution not only allows for an efficient management but also makes easier the concepts and data access for external developers, who are not necessarily familiar with the concepts and tools related to oceanographic or atmospheric data. The SOCIB App for Android (https://play.google.com/store/apps/details?id=com.socib) uses that API as a "data backend", in such a way that it is straightforward to manage which information is shown by the application, without having to modify and upload it again. The only pieces of information that do not depend on the services are the App "Sections" and "Screens", but the content displayed in each of them is obtained through requests to the web services. The API is not used only for the smartphone app: presently, most of SOCIB applications for data visualisation

  6. There's an App for That: A Guide for Healthcare Practitioners and Researchers on Smartphone Technology.

    Science.gov (United States)

    Trevena, Lyndal

    2015-01-01

    Smartphone technology is nascent compared to other technologies; however, it has shown an unprecedented uptake amongst lay consumers and professionals. This article presents the history, components, and key features of smartphones, as well as their related concepts and how they work, and it also delineates the process of smartphone applications (apps) development and publishing in the app stores. It also describes and discusses smartphone technology utilisation for health consumers, healthcare professionals, and health researchers, as well as the regulations of health-related apps.

  7. Finding a Depression App: A Review and Content Analysis of the Depression App Marketplace

    Science.gov (United States)

    Shen, Nelson; Levitan, Michael-Jane; Johnson, Andrew; Bender, Jacqueline Lorene; Hamilton-Page, Michelle; Jadad, Alejandro (Alex) R

    2015-01-01

    Background Depression is highly prevalent and causes considerable suffering and disease burden despite the existence of wide-ranging treatment options. Mobile phone apps offer the potential to help close this treatment gap by confronting key barriers to accessing support for depression. Objectives Our goal was to identify and characterize the different types of mobile phone depression apps available in the marketplace. Methods A search for depression apps was conducted on the app stores of the five major mobile phone platforms: Android, iPhone, BlackBerry, Nokia, and Windows. Apps were included if they focused on depression and were available to people who self-identify as having depression. Data were extracted from the app descriptions found in the app stores. Results Of the 1054 apps identified by the search strategy, nearly one-quarter (23.0%, 243/1054) unique depression apps met the inclusion criteria. Over one-quarter (27.7%, 210/758) of the excluded apps failed to mention depression in the title or description. Two-thirds of the apps had as their main purpose providing therapeutic treatment (33.7%, 82/243) or psychoeducation (32.1%, 78/243). The other main purpose categories were medical assessment (16.9%, 41/243), symptom management (8.2%, 20/243), and supportive resources (1.6%, 4/243). A majority of the apps failed to sufficiently describe their organizational affiliation (65.0%, 158/243) and content source (61.7%, 150/243). There was a significant relationship (χ 2 5=50.5, Pbook (20.6%, 50/243), audio therapy (16.9%, 41/243), or screening (16.9%, 41/243) function. Most apps had a dynamic user interface (72.4%, 176/243) and used text as the main type of media (51.9%, 126/243), and over a third (14.4%, 35/243) incorporated more than one form of media. Conclusion Without guidance, finding an appropriate depression app may be challenging, as the search results yielded non-depression–specific apps to depression apps at a 3:1 ratio. Inadequate reporting of

  8. COMBINING REUSABLE TEST CASES AND CONTINUOUS SECURITY TESTING FOR REDUCING WEB APPS SECURITY RISKS

    Directory of Open Access Journals (Sweden)

    Sen-Tarng Lai

    2016-11-01

    Full Text Available In network communication age, information technology is being at the continuous and rapid evolutionprocess. Network access equipment, information system and Web Apps must rapidly and continuouslyupdate to meet the user interested requirements. Major challenge of Web Apps frequent changes is the security of user personal data and transactions information. Vulnerability scanning and penetration testing are the routine methods to improve the security of Web App. However, these two ways not only timeconsuming,but also require too many resources. For coping the continuous changes, in the limitedresources, security testing not only need to be timely completed, but also should concern testing quality.Otherwise, every change maintenance cannot avoid to cause the security risk of new version App. Based on reusable test cases, this paper proposes the continuous security testing procedure (CSTP, using test casesreusability to increase security test efficiency. In Web Apps maintenance process of limited resources, CSTPcan timely handle security testing and quickly identify Web Apps vulnerabilities and defects. Assisting Apps maintainer effectively repair security defects and concretely improve the security of user personal data and transaction information.

  9. Pro JavaScript for web apps

    CERN Document Server

    Freeman, Adam

    2012-01-01

    JavaScript is the engine behind every web app, and a solid knowledge of it is essential for all modern web developers. Pro JavaScript for Web Apps gives you all of the information that you need to create professional, optimized, and efficient JavaScript applications that will run across all devices. It takes you through all aspects of modern JavaScript application creation, showing you how to combine JavaScript with the new features of HTML5 and CSS3 to make the most of the new web technologies. The focus of the book is on creating professional web applications, ensuring that your app provides

  10. Creating mobile apps with Appcelerator Titanium

    CERN Document Server

    Brousseau, Christian

    2013-01-01

    Creating Mobile Apps with Appcelerator Titanium provides a hands-on approach and working examples on creating apps and games as well as embedding them onto a social networking website. Developers can then move on from there to develop their own applications based on the ones they have developed throughout the course of this book.""Creating Mobile Apps with Appcelerator Titanium"" is for developers who have experience with modern languages and development environments. Also, if you are familiar with the concepts of Object-oriented Programming (OOP), reusable components, AJAX closures, and so on

  11. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production

    Science.gov (United States)

    Poksay, Karen S.; Sheffler, Douglas J.; Spilman, Patricia; Campagna, Jesus; Jagodzinska, Barbara; Descamps, Olivier; Gorostiza, Olivia; Matalis, Alex; Mullenix, Michael; Bredesen, Dale E.; Cosford, Nicholas D. P.; John, Varghese

    2017-01-01

    Alzheimer’s disease (AD) is characterized by neuronal and synaptic loss. One process that could contribute to this loss is the intracellular caspase cleavage of the amyloid precursor protein (APP) resulting in release of the toxic C-terminal 31-amino acid peptide APP-C31 along with the production of APPΔC31, full-length APP minus the C-terminal 31 amino acids. We previously found that a mutation in APP that prevents this caspase cleavage ameliorated synaptic loss and cognitive impairment in a murine AD model. Thus, inhibition of this cleavage is a reasonable target for new therapeutic development. In order to identify small molecules that inhibit the generation of APP-C31, we first used an APPΔC31 cleavage site-specific antibody to develop an AlphaLISA to screen several chemical compound libraries for the level of N-terminal fragment production. This antibody was also used to develop an ELISA for validation studies. In both high throughput screening (HTS) and validation testing, the ability of compounds to inhibit simvastatin- (HTS) or cerivastatin- (validation studies) induced caspase cleavage at the APP-D720 cleavage site was determined in Chinese hamster ovary (CHO) cells stably transfected with wildtype (wt) human APP (CHO-7W). Several compounds, as well as control pan-caspase inhibitor Q-VD-OPh, inhibited APPΔC31 production (measured fragment) and rescued cell death in a dose-dependent manner. The effective compounds fell into several classes including SERCA inhibitors, inhibitors of Wnt signaling, and calcium channel antagonists. Further studies are underway to evaluate the efficacy of lead compounds – identified here using cells and tissues expressing wt human APP – in mouse models of AD expressing mutated human APP, as well as to identify additional compounds and determine the mechanisms by which they exert their effects.

  12. Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production.

    Science.gov (United States)

    Poksay, Karen S; Sheffler, Douglas J; Spilman, Patricia; Campagna, Jesus; Jagodzinska, Barbara; Descamps, Olivier; Gorostiza, Olivia; Matalis, Alex; Mullenix, Michael; Bredesen, Dale E; Cosford, Nicholas D P; John, Varghese

    2017-01-01

    Alzheimer's disease (AD) is characterized by neuronal and synaptic loss. One process that could contribute to this loss is the intracellular caspase cleavage of the amyloid precursor protein (APP) resulting in release of the toxic C-terminal 31-amino acid peptide APP-C31 along with the production of APPΔC31, full-length APP minus the C-terminal 31 amino acids. We previously found that a mutation in APP that prevents this caspase cleavage ameliorated synaptic loss and cognitive impairment in a murine AD model. Thus, inhibition of this cleavage is a reasonable target for new therapeutic development. In order to identify small molecules that inhibit the generation of APP-C31, we first used an APPΔC31 cleavage site-specific antibody to develop an AlphaLISA to screen several chemical compound libraries for the level of N-terminal fragment production. This antibody was also used to develop an ELISA for validation studies. In both high throughput screening (HTS) and validation testing, the ability of compounds to inhibit simvastatin- (HTS) or cerivastatin- (validation studies) induced caspase cleavage at the APP-D720 cleavage site was determined in Chinese hamster ovary (CHO) cells stably transfected with wildtype (wt) human APP (CHO-7W). Several compounds, as well as control pan-caspase inhibitor Q-VD-OPh, inhibited APPΔC31 production (measured fragment) and rescued cell death in a dose-dependent manner. The effective compounds fell into several classes including SERCA inhibitors, inhibitors of Wnt signaling, and calcium channel antagonists. Further studies are underway to evaluate the efficacy of lead compounds - identified here using cells and tissues expressing wt human APP - in mouse models of AD expressing mutated human APP, as well as to identify additional compounds and determine the mechanisms by which they exert their effects.

  13. Beyond Self-Tracking and Reminders: Designing Smartphone Apps That Support Habit Formation

    OpenAIRE

    Stawarz, K. M.; Cox, A. L.; Blandford, A.

    2015-01-01

    Habit formation is an important part of behavior change interventions: to ensure an intervention has long-term effects, the new behavior has to turn into a habit and become automatic. Smartphone apps could help with this process by supporting habit formation. To better understand how, we conducted a 4-week study exploring the influence of different types of cues and positive reinforcement on habit formation and reviewed the functionality of 115 habit formation apps. We discovered that relying...

  14. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease.

    Science.gov (United States)

    Triaca, Viviana; Sposato, Valentina; Bolasco, Giulia; Ciotti, Maria Teresa; Pelicci, Piergiuseppe; Bruni, Amalia C; Cupidi, Chiara; Maletta, Raffaele; Feligioni, Marco; Nisticò, Robert; Canu, Nadia; Calissano, Pietro

    2016-08-01

    NGF has been implicated in forebrain neuroprotection from amyloidogenesis and Alzheimer's disease (AD). However, the underlying molecular mechanisms are still poorly understood. Here, we investigated the role of NGF signalling in the metabolism of amyloid precursor protein (APP) in forebrain neurons using primary cultures of septal neurons and acute septo-hippocampal brain slices. In this study, we show that NGF controls the basal level of APP phosphorylation at Thr668 (T668) by downregulating the activity of the Ser/Thr kinase JNK(p54) through the Tyr kinase signalling adaptor SH2-containing sequence C (ShcC). We also found that the specific NGF receptor, Tyr kinase A (TrkA), which is known to bind to APP, fails to interact with the fraction of APP molecules phosphorylated at T668 (APP(pT668) ). Accordingly, the amount of TrkA bound to APP is significantly reduced in the hippocampus of ShcC KO mice and of patients with AD in which elevated APP(pT668) levels are detected. NGF promotes TrkA binding to APP and APP trafficking to the Golgi, where APP-BACE interaction is hindered, finally resulting in reduced generation of sAPPβ, CTFβ and amyloid-beta (1-42). These results demonstrate that NGF signalling directly controls basal APP phosphorylation, subcellular localization and BACE cleavage, and pave the way for novel approaches specifically targeting ShcC signalling and/or the APP-TrkA interaction in AD therapy.

  15. THE POTENTIAL OF BIOCHEMISTRY EDUCATION APPS IN THE FORMATIVE ASSESSMENT

    Directory of Open Access Journals (Sweden)

    M. L. Oliveira

    2015-08-01

    Full Text Available Introduction and objectives: Apps can be designed to provide usage data, and most of them do. These data are usually used to map users interests and to deliver more effective ads that are more likely to result in clicks, and sales. We have applied some of these metrics to understand how can it be used to map students’ behavior and to promote a formative assessment using educational software. The purpose of a formative assessment is to monitor student learning to provide ongoing feedback that can be used by instructors and students to improve the teaching and learning process. Thus, this modality aims to help both students and instructors to identify strengths and weaknesses that need to be developed. This study aimed to describe the potential of educational apps in the formative assessment process. Material and Methods: We have implemented assessment tools embedded in three apps (ARMET, The Cell and 3D Class used to teach: 1 Metabolic Pathways; 2 Scale of the cellular structures, and 3 Concepts from techniques used in a Biochemistry Lab course. The implemented tools allow to verify on what issues there were recurring mistakes, the total number of mistakes presented, which questions they most achieved, how long they took to perform the activity and other relevant information. Results and conclusion: Educational apps can provide transparent and coherent evaluation metrics to enable instructors to systematize more consistent criteria and indicators, reducing the subjectivity of the formative assessment process and the time spent for preparation, tabulation and analysis of assessment data. This approach allows instructors to understand better where students struggle, giving to them a more effective feedback. It also helps instructor to plan interventions to help students to perform better and to achieve the learning objectives.

  16. iOS app development for dummies

    CERN Document Server

    Feiler, Jesse

    2014-01-01

    If you've got incredible iOS ideas, get this book and bring them to life! iOS 7 represents the most significant update to Apple's mobile operating system since the first iPhone was released, and even the most seasoned app developers are looking for information on how to take advantage of the latest iOS 7 features in their app designs. That's where iOS App Development For Dummies comes in! Whether you're a programming hobbyist wanting to build an app for fun or a professional developer looking to expand into the iOS market, this book will walk you through the fundamentals of building a univer

  17. Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.

    Directory of Open Access Journals (Sweden)

    Chun-Yan Wang

    Full Text Available BACKGROUND: Abnormal zinc homeostasis is involved in β-amyloid (Aβ plaque formation and, therefore, the zinc load is a contributing factor in Alzheimer's disease (AD. However, the involvement of zinc in amyloid precursor protein (APP processing and Aβ deposition has not been well established in AD animal models in vivo. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, APP and presenilin 1 (PS1 double transgenic mice were treated with a high dose of zinc (20 mg/ml ZnSO4 in drinking water. This zinc treatment increased APP expression, enhanced amyloidogenic APP cleavage and Aβ deposition, and impaired spatial learning and memory in the transgenic mice. We further examined the effects of zinc overload on APP processing in SHSY-5Y cells overexpressing human APPsw. The zinc enhancement of APP expression and cleavage was further confirmed in vitro. CONCLUSIONS/SIGNIFICANCE: The present data indicate that excess zinc exposure could be a risk factor for AD pathological processes, and alteration of zinc homeostasis is a potential strategy for the prevention and treatment of AD.

  18. APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.

    Science.gov (United States)

    Grimm, Marcus O W; Mett, Janine; Stahlmann, Christoph P; Grösgen, Sven; Haupenthal, Viola J; Blümel, Tamara; Hundsdörfer, Benjamin; Zimmer, Valerie C; Mylonas, Nadine T; Tanila, Heikki; Müller, Ulrike; Grimm, Heike S; Hartmann, Tobias

    2015-01-01

    Alzheimer's disease (AD) is characterized by an accumulation of Amyloid-β (Aβ), released by sequential proteolytic processing of the amyloid precursor protein (APP) by β - and γ-secretase. Aβ peptides can aggregate, leading to toxic Aβ oligomers and amyloid plaque formation. Aβ accumulation is not only dependent on de novo synthesis but also on Aβ degradation. Neprilysin (NEP) is one of the major enzymes involved in Aβ degradation. Here we investigate the molecular mechanism of NEP regulation, which is up to now controversially discussed to be affected by APP processing itself. We found that NEP expression is highly dependent on the APP intracellular domain (AICD), released by APP processing. Mouse embryonic fibroblasts devoid of APP processing, either by the lack of the catalytically active subunit of the γ-secretase complex [presenilin (PS) 1/2] or by the lack of APP and the APP-like protein 2 (APLP2), showed a decreased NEP expression, activity and protein level. Similar results were obtained by utilizing cells lacking a functional AICD domain (APPΔCT15) or expressing mutations in the genes encoding for PS1. AICD supplementation or retransfection with an AICD encoding plasmid could rescue the down-regulation of NEP further strengthening the link between AICD and transcriptional NEP regulation, in which Fe65 acts as an important adaptor protein. Especially AICD generated by the amyloidogenic pathway seems to be more involved in the regulation of NEP expression. In line, analysis of NEP gene expression in vivo in six transgenic AD mouse models (APP and APLP2 single knock-outs, APP/APLP2 double knock-out, APP-swedish, APP-swedish/PS1Δexon9, and APPΔCT15) confirmed the results obtained in cell culture. In summary, in the present study we clearly demonstrate an AICD-dependent regulation of the Aβ-degrading enzyme NEP in vitro and in vivo and elucidate the underlying mechanisms that might be beneficial to develop new therapeutic strategies for the

  19. Development of an app for compressible flow “App4Comp”

    OpenAIRE

    Adam Alberdi, Andrés; Gámez Montero, Pedro Javier

    2015-01-01

    In this paper is discussed the development and operation of a new Android App made through Google’s platform App Inventor 2. This App is focused on solving classic problems related to compressible flow, dealing with the typical cases seen in the subject of Fluid Mechanics of a degree in Aeronautics. It is downloadable from [1], or through the QR code at the end of this paper. The main objective of this project was to bring in a new, useful app about compressible flow to the market, but als...

  20. Melanoma detection using a mobile phone app

    Science.gov (United States)

    Diniz, Luciano E.; Ennser, K.

    2016-03-01

    Mobile phones have had their processing power greatly increased since their invention a few decades ago. As a direct result of Moore's Law, this improvement has made available several applications that were impossible before. The aim of this project is to develop a mobile phone app, integrated with its camera coupled to an amplifying lens, to help distinguish melanoma. The proposed device has the capability of processing skin mole images and suggesting, using a score system, if it is a case of melanoma or not. This score system is based on the ABCDE signs of melanoma, and takes into account the area, the perimeter and the colors present in the nevus. It was calibrated and tested using images from the PH2 Dermoscopic Image Database from Pedro Hispano Hospital. The results show that the system created can be useful, with an accuracy of up to 100% for malign cases and 80% for benign cases (including common and atypical moles), when used in the test group.

  1. A Self-Regulation Theory–Based Asthma Management Mobile App for Adolescents: A Usability Assessment

    Science.gov (United States)

    2017-01-01

    Background Self-regulation theory suggests people learn to influence their own behavior through self-monitoring, goal-setting, feedback, self-reward, and self-instruction, all of which smartphones are now capable of facilitating. Several mobile apps exist to manage asthma; however, little evidence exists about whether these apps employ user-centered design processes that adhere to government usability guidelines for mobile apps. Objective Building upon a previous study that documented adolescent preferences for an asthma self-management app, we employed a user-centered approach to assess the usability of a high-fidelity wireframe for an asthma self-management app intended for use by adolescents with persistent asthma. Methods Individual interviews were conducted with adolescents (ages 11-18 years) with persistent asthma who owned a smartphone (N=8). Adolescents were asked to evaluate a PDF app wireframe consisting of 76 screen shots displaying app features, including log in and home screen, profile setup, settings and info, self-management features, and graphical displays for charting asthma control and medication. Preferences, comments, and suggestions for each set of screen shots were assessed using the audio-recorded interviews. Two coders reached consensus on adolescent evaluations of the following aspects of app features: (1) usability, (2) behavioral intentions to use, (3) confusing aspects, and (4) suggestions for improvement. Results The app wireframe was generally well received, and several suggestions for improvement were recorded. Suggestions included increased customization of charts and notifications, reminders, and alerts. Participants preferred longitudinal data about asthma control and medication use to be displayed using line graphs. All participants reported that they would find an asthma management app like the one depicted in the wireframe useful for managing their asthma. Conclusions Early stage usability tests guided by government usability

  2. Airport Surface Access and Mobile Apps

    Directory of Open Access Journals (Sweden)

    Luis Martin-Domingo

    2015-02-01

    Full Text Available Purpose: Airport Surface Access faces two main opposite issues: (1 cars, being the main transport mode, contribute to the increasing level of congestion and pollution of cities; and (2 simultaneously, parking fees are one important source of airports commercial revenue, creating a dilemma for airports when facing the problem. Following the recent trend of air passengers travelling with Smartphone (78% in 2013, the purpose of this paper is to monitor the adoption of mobile Applications (Apps by airports and to analyze if the information and functions provided in those Apps can help to overcome the above two issues. Design/methodology/approach: 31 iPhone App of some of the largest European airports were evaluated in the lab using the evaluation model of Destinations Mobile Applications (Scolari and Fernández-Cavia 2014 adapted for for the Airport Surface Access on Airport Apps Findings and Originality/value: The Apps evaluated provided a very limited functionality to help passengers to plan and book their trips to/from the airports on public transports and gave high priority to parking information and services. Originality/value: Although Airport Surface Access has been a widely researched, the originality of this paper is the analysis of airport mobile Apps as a potential tool for airports to deal with the surface airport access problems.Access, Airports, Mobile Internet, Commercial Revenues

  3. What makes a good clinical app? Introducing the RCP Health Informatics Unit checklist.

    Science.gov (United States)

    Wyatt, Jeremy C; Thimbleby, Harold; Rastall, Paul; Hoogewerf, Jan; Wooldridge, Darren; Williams, John

    2015-12-01

    Doctors increasingly rely on medical apps running on smart phones or tablet computers to support their work. However, these apps vary hugely in the quality of their data input screens, internal data processing, the methods used to handle sensitive patient data and how they communicate their output to the user. Inspired by Donabedian's approach to assessing quality and the principles of good user interface design, the Royal College of Physicians' Health Informatics Unit has developed and piloted an 18-item checklist to help clinicians assess the structure, functions and impact of medical apps. Use of this checklist should help clinicians to feel more confident about using medical apps themselves, about recommending them to their staff or prescribing them for patients.

  4. The Top Chinese Mobile Health Apps: A Systematic Investigation

    Science.gov (United States)

    Hsu, Jeffrey; Liu, Di; Yu, Ya Min; Zhao, Hui Tong; Chen, Zhi Rou; Li, Jiao

    2016-01-01

    Background China’s mHealth market is on track to become a global leader by industry size. The Chinese mobile app market and health care system have peculiarities that distinguish them from other app markets. To date, Chinese mHealth apps have not been systematically investigated. Objective The objective of this study was to provide an overview of Chinese mHealth apps as of December 2015. Methods We identified and investigated the most downloaded apps from the iOS and Android platforms. For each app, we analyzed and recorded its main service offered, mHealth initiative, disease and specialty focus, app cost, target user, Web app availability, and emphasis on information security. Standard descriptive statistics were used. Results A total of 234 apps met the inclusion criteria and were investigated. The apps targeting nonhealth care professionals focused on providing telemedicine and appointment-making services. The apps targeting health care professionals focused on education and peer reviewed articles. The most common disease-specific apps focused primarily on diabetes, hypertension, and hepatitis management. Most apps were free and available on both iOS and Android platforms. Conclusions The primary mHealth initiatives targeted by the apps reflect Chinese patients’ demand for access to medical care. Disease-specific apps are also representative of disease prevalence in China. Government press releases suggest that new policies on the horizon may shift the industry. PMID:27573724

  5. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.

    Directory of Open Access Journals (Sweden)

    Steve Pedrini

    2005-01-01

    Full Text Available BACKGROUND: Statins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent evidence suggests that statin use may be associated with a decreased risk for Alzheimer disease, although the mechanisms underlying this apparent risk reduction are poorly understood. One popular hypothesis for statin action is related to the drugs' ability to activate alpha-secretase-type shedding of the alpha-secretase-cleaved soluble Alzheimer amyloid precursor protein ectodomain (sAPP(alpha. Statins also inhibit the isoprenoid pathway, thereby modulating the activities of the Rho family of small GTPases-Rho A, B, and C-as well as the activities of Rac and cdc42. Rho proteins, in turn, exert many of their effects via Rho-associated protein kinases (ROCKs. Several cell-surface molecules are substrates for activated alpha-secretase-type ectodomain shedding, and regulation of shedding typically occurs via activation of protein kinase C or extracellular-signal-regulated protein kinases, or via inactivation of protein phosphatase 1 or 2A. However, the possibility that these enzymes play a role in statin-stimulated shedding has been excluded, leading us to investigate whether the Rho/ROCK1 protein phosphorylation pathway might be involved. METHODS AND FINDINGS: We found that both atorvastatin and simvastatin stimulated sAPP(alpha shedding from a neuroblastoma cell line via a subcellular mechanism apparently located upstream of endocytosis. A farnesyl transferase inhibitor also increased sAPP(alpha shedding, as did a dominant negative form of ROCK1. Most conclusively, a constitutively active ROCK1 molecule inhibited statin-stimulated sAPP(alpha shedding. CONCLUSION: Together, these data suggest that statins exert their effects on shedding of sAPP(alpha from cultured cells, at least in part, by modulation of the isoprenoid pathway and ROCK1.

  6. "WhatsApp"ening in orthopedic care: a concise report from a 300-bedded tertiary care teaching center.

    Science.gov (United States)

    Khanna, Vishesh; Sambandam, Senthil N; Gul, Arif; Mounasamy, Varatharaj

    2015-07-01

    Smartphones have emerged as essential tools providing assistance in patient care, monitoring, rehabilitation, communication, diagnosis, teaching, research and reference. Among innumerable communication apps, WhatsApp has been widely popular and cost effective. The aim of our study was to report the impact of introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool on (1) awareness of patient-related information, (2) efficiency of the handover process and (3) duration of traditional morning handovers among orthopedic residents in a 300-bedded tertiary care teaching center. Written handovers and paging used for communication at our center led to occasional inefficiencies among residents. Widespread use, low cost, availability and double password protection (phone lock and WhatsApp lock) made WhatsApp's group conversation feature an ideal tool for intradepartmental patient-related communication. Twenty-five consecutive admissions before and after WhatsApp (BW, AW) were included in the study. Eight orthopedic residents attempted fifty randomly arranged questions based on the twenty-five patients in each study period. A null hypothesis that introduction of WhatsApp group would neither increase the awareness of patient-related information nor improve the efficiency of the handovers among residents was assumed. A significant improvement observed in scores obtained by residents in the AW group led to rejection of the null hypothesis. The residents also reported swifter and efficient handovers after the introduction of WhatsApp. Our results indicate that the introduction of a smartphone app "WhatsApp" as an intradepartmental communication tool can bring about an improvement in patient-related awareness, communication and handovers among orthopedic residents.

  7. Epic Allies: Development of a Gaming App to Improve Antiretroviral Therapy Adherence Among Young HIV-Positive Men Who Have Sex With Men

    Science.gov (United States)

    Muessig, Kathryn Elizabeth; McNulty, Tobias; Soni, Karina; Knudtson, Kelly; Lemann, Alex; Nwoko, Nkechinyere; Hightow-Weidman, Lisa B

    2016-01-01

    Background In the United States, the human immunodeficiency virus (HIV) disproportionately affects young men who have sex with men (YMSM). For HIV-positive individuals, adherence to antiretroviral therapy (ART) is critical for achieving optimal health outcomes and reducing secondary transmission of HIV. However, YMSM often struggle with ART adherence. Novel mobile phone apps that incorporate game-based mechanics and social networking elements represent a promising intervention approach for improving ART adherence among YMSM. Objective This study used a multiphase, iterative development process to create an ART adherence app for YMSM. Methods The three-phase development process included: (1) theory-based concept development jointly by public health researchers and the technology team, (2) assessment of the target population’s ART adherence needs and app preferences and development and testing of a clickable app prototype, and (3) development and usability testing of the final app prototype. Results The initial theory-based app concept developed in Phase One included medication reminders, daily ART adherence tracking and visualization, ART educational modules, limited virtual interactions with other app users, and gamification elements. In Phase Two, adherence needs, including those related to information, motivation, and behavioral skills, were identified. Participants expressed preferences for an ART adherence app that was informational, interactive, social, and customizable. Based on the findings from Phase Two, additional gaming features were added in Phase Three, including an interactive battle, superhero app theme, and app storyline. Other features were modified to increase interactivity and customization options and integrate the game theme. During usability testing of the final prototype, participants were able to understand and navigate the app successfully and rated the app favorably. Conclusions An iterative development process was critical for the

  8. Phytochrome-mediated Carotenoids Biosynthesis in Ripening Tomatoes.

    Science.gov (United States)

    Thomas, R L; Jen, J J

    1975-09-01

    Red light induced and far red light inhibited carotenoid biosynthesis in ripening tomatoes (Lycopersicon esculentum Mill.) when compared to controls kept in the dark. Red illumination following far red illumination reversed the inhibitory action of far red light on carotenoid biosynthesis, suggesting a phytochrome-mediated process. Quantitation of individual carotenoids favored the hypothesis of two separate carotenoid biosynthetic pathways in tomatoes.

  9. Good gene, bad gene: new APP variant may be both.

    Science.gov (United States)

    Di Fede, Giuseppe; Catania, Marcella; Morbin, Michela; Giaccone, Giorgio; Moro, Maria Luisa; Ghidoni, Roberta; Colombo, Laura; Messa, Massimo; Cagnotto, Alfredo; Romeo, Margherita; Stravalaci, Matteo; Diomede, Luisa; Gobbi, Marco; Salmona, Mario; Tagliavini, Fabrizio

    2012-12-01

    APP mutations cause Alzheimer disease (AD) with virtually complete penetrance. We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline. It is noteworthy that the heterozygous relatives were not affected, suggesting that this mutation is inherited as an autosomal recessive trait. Studies on molecular events for the recessive mutation in causing disease revealed a double synergistic effect: the A673V APP variant shifts APP processing towards the amyloidogenic pathway with increased production of Aβ peptides and it markedly enhances the aggregation and fibrillogenic properties of both Aβ1-40 and Aβ1-42. However, co-incubation of mutated and wild-type (wt) Aβ species resulted in inhibition of amyloidogenesis, consistent with the observation that heterozygous carriers do not develop the disease. The opposite effects of the A673V mutation in the homozygous and heterozygous state on amyloidogenesis account for the autosomal recessive pattern of inheritance, revealing a new scenario in AD genetics and pathogenesis. The anti-amyloidogenic properties of this novel human Aβ variant may offer grounds for the development of therapeutic strategies for AD based on modified Aβ peptides. Indeed, the interaction between mutated Aβ1-6 and wt full-length Aβ prevents amyloid fibril formation. The anti-amyloidogenic effect is further amplified by the use of a mutated six-mer peptide, constructed entirely from D-amino acids to increase the its stability in vivo. Here we reviewed the studies on pathogenic mechanisms associated with the A673V mutation and the first experimental steps toward the development of a novel disease-modifying therapy for AD.

  10. APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.

    Science.gov (United States)

    Walton, J R; Wang, M-X

    2009-11-01

    Up-regulated expression of amyloid precursor protein (APP) occurs early in the cascade of events that leads to amyloid plaque formation in the human brain. APP gene up-regulation, mediated by activated NF-kappaB, is a response to stress from nM concentrations of aluminum ions, aluminum-disregulated iron ions, reactive-oxygen species, cytokines, and physical trauma. We examined in vivo effects of aluminum on APP in aged rats, obtained from previously-reported longitudinal studies, that chronically ingested aluminum in amounts equivalent to total dietary aluminum levels that Americans routinely ingest. These rats exhibited two outcomes: one group remained cognitively-intact, scoring as well on a memory-discrimination task in old age as in middle age. The other developed cognitive deterioration, obtaining significantly lower mean performance scores in old age than in middle age and exhibiting abnormal behaviors associated with dementia. We compared the expression, distribution and accumulation of APP in hippocampal and cortical tissue of these two rat groups. Compared to results from cognitively-intact rats, hippocampal and cortical tissue from the cognitively-deteriorated rats showed elevated APP gene expression, significantly more dense APP deposits in cytoplasm of neural cells, and APP-immunoreactive neurites that were swollen and varicose. This study shows aluminum routinely derived from chronic oral ingestion, that gradually accumulates in brain regions important for memory-processing, is sufficient to increase APP levels in neural cells of those regions. Aluminum may thus launch the cascade that results in the formation of amyloid plaques in human brain.

  11. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease.

    Science.gov (United States)

    Nalivaeva, Natalia N; Turner, Anthony J

    2016-11-25

    The amyloid precursor protein (APP) and acetylcholinesterase (AChE) are multi-faceted proteins with a wide range of vital functions, both crucially linked with the pathogenesis of Alzheimer's disease (AD). APP is the precursor of the Aβ peptide, the pathological agent in AD, while AChE is linked to its pathogenesis either by increasing cholinergic deficit or exacerbating Aβ fibril formation and toxicity. As such, both proteins are the main targets in AD therapeutics with AChE inhibitors being currently the only clinically available AD drugs. In our studies we have demonstrated an important inter-relation in functioning of these proteins. Both can be released from the cell membrane and we have shown that AChE shedding involves a metalloproteinase-mediated mechanism which, like the α-secretase dependent cleavage of APP, is stimulated by cholinergic agonists. Overexpression of the neuronal specific isoform APP695 in neuronal cells substantially decreased levels of the AChE mRNA, protein and catalytic activity accompanied by a similar decrease in mRNA levels of the AChE membrane anchor, PRiMA (proline rich membrane anchor). We further established that this regulation does not involve APP processing and its intracellular domain (AICD) but requires the E1 region of APP, specifically its copper-binding domain. On the contrary, siRNA knock-down of APP in cholinergic SN56 cells resulted in a significant upregulation of AChE mRNA levels. Hence APP may influence AChE physiology while released AChE may regulate amyloidogenesis through multiple mechanisms suggesting novel therapeutic targets.

  12. The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

    Energy Technology Data Exchange (ETDEWEB)

    S Lee; Y Xue; J Hulbert; Y Wang; X Liu; B Demeler; Y Ha

    2011-12-31

    Amyloid precursor protein (APP) is genetically linked to Alzheimer's disease. APP is a type I membrane protein, and its oligomeric structure is potentially important because this property may play a role in its function or affect the processing of the precursor by the secretases to generate amyloid {beta}-peptide. Several independent studies have shown that APP can form dimers in the cell, but how it dimerizes remains controversial. At least three regions of the precursor, including a centrally located and conserved domain called E2, have been proposed to contribute to dimerization. Here we report two new crystal structures of E2, one from APP and the other from APLP1, a mammalian APP homologue. Comparison with an earlier APP structure, which was determined in a different space group, shows that the E2 domains share a conserved and antiparallel mode of dimerization. Biophysical measurements in solution show that heparin binding induces E2 dimerization. The 2.1 {angstrom} resolution electron density map also reveals phosphate ions that are bound to the protein surface. Mutational analysis shows that protein residues interacting with the phosphate ions are also involved in heparin binding. The locations of two of these residues, Arg-369 and His-433, at the dimeric interface suggest a mechanism for heparin-induced protein dimerization.

  13. Analyzing Remote Server Locations for Personal Data Transfers in Mobile Apps

    Directory of Open Access Journals (Sweden)

    Eskandari Mojtaba

    2017-01-01

    Full Text Available The prevalence of mobile devices and their capability to access high speed internet has transformed them into a portable pocket cloud interface. Being home to a wide range of users’ personal data, mobile devices often use cloud servers for storage and processing. The sensitivity of a user’s personal data demands adequate level of protection at the back-end servers. In this regard, the European Union Data Protection regulations (e.g., article 25.1 impose restriction on the locations of European users’ personal data transfer. The matter of concern, however, is the enforcement of such regulations. The first step in this regard is to analyze mobile apps and identify the location of servers to which personal data is transferred. To this end, we design and implement an app analysis tool, PDTLoc (Personal Data Transfer Location Analyzer, to detect violation of the mentioned regulations. We analyze 1, 498 most popular apps in the EEA using PDTLoc to investigate the data recipient server locations. We found that 16.5% (242 of these apps transfer users’ personal data to servers located at places outside Europe without being under the control of a data protection framework. Moreover, we inspect the privacy policies of the apps revealing that 51% of these apps do not provide any privacy policy while almost all of them contact the servers hosted outside Europe.

  14. CERN Apps meet in a forum

    CERN Multimedia

    Antonella Del Rosso

    2013-01-01

    In the fast-evolving world of mobile apps, creativity and usability are key words. For the time being, the number of CERN apps is quite limited but the situation could quickly change. An information-sharing forum set up by the IT Department is a starting point to channel your creativity with the help of experts, best practices and useful guidelines.   The CAPPS (CERN Apps) Forum was set up about a year ago. Its members come from various departments and meet every two or three months to update each other on the apps that are in preparation, share the latest news on the available software, discuss best practices and so on. “The Forum is open to anybody wanting to develop apps at CERN,” explains David Foster, Deputy Department Head and initiator of the CAPPS Forum. “Developers, communication experts and IT infrastructure experts meet and discuss various topics, from branding-related issues to coding and implementation solutions. The aim is to go forward in a coherent way...

  15. Traumatic Brain Injury Increases the Expression of Nos1, Aβ Clearance, and Epileptogenesis in APP/PS1 Mouse Model of Alzheimer's Disease.

    Science.gov (United States)

    Miszczuk, Diana; Dębski, Konrad J; Tanila, Heikki; Lukasiuk, Katarzyna; Pitkänen, Asla

    2016-12-01

    To test the hypothesis that an amyloidogenic genetic background predisposes to worsening of post-TBI outcome, we investigated whether traumatic brain injury (TBI) in amyloid precursor protein (APP)/PS1 mice aggravates epileptogenesis and/or enhances somatomotor and cognitive impairment. To elaborate the mechanisms of worsening outcomes, we studied changes in the expression of genes involved in APP processing and Tau pathways in the perilesional cortex, ipsilateral thalamus, and ipsilateral hippocampus 16 weeks post-TBI. Mild (mTBI) or severe TBI (sTBI) was triggered using controlled cortical impact in 3-month-old APP/PS1 mice and wild-type (Wt) littermates. Morris water-maze revealed a genotype effect on spatial learning and memory as APP/PS1-sTBI mice performed more poorly than Wt-sTBI mice (p APP/PS1-sTBI mice had epilepsy compared to 11 % in Wt-sTBI (genotype effect p APP/PS1-sham groups (TBI effect p APP/PS1-sTBI mice compared to APP/PS1-sham (p APP/PS1-sTBI mice compared to APP/PS1-sham mice (p < 0.05). The present study provides the first comprehensive evidence of exacerbated epileptogenesis and its molecular mechanisms in Alzheimer's disease (AD)-related genetic background after TBI.

  16. Palmitoylated APP Forms Dimers, Cleaved by BACE1

    OpenAIRE

    Bhattacharyya, Raja; Fenn, Rebecca H.; Barren, Cory; Tanzi, Rudolph E.; Kovacs, Dora M.

    2016-01-01

    A major rate-limiting step for Aβ generation and deposition in Alzheimer’s disease brains is BACE1-mediated cleavage (β-cleavage) of the amyloid precursor protein (APP). We previously reported that APP undergoes palmitoylation at two cysteine residues (Cys186 and Cys187) in the E1-ectodomain. 8–10% of total APP is palmitoylated in vitro and in vivo. Palmitoylated APP (palAPP) shows greater preference for β-cleavage than total APP in detergent resistant lipid rafts. Protein palmitoylation is k...

  17. Biosynthesis of gold nanoparticles: A green approach.

    Science.gov (United States)

    Ahmed, Shakeel; Annu; Ikram, Saiqa; Yudha S, Salprima

    2016-08-01

    Nanotechnology is an immensely developing field due to its extensive range of applications in different areas of technology and science. Different types of methods are employed for synthesis of nanoparticles due to their wide applications. The conventional chemical methods have certain limitations with them either in the form of chemical contaminations during their syntheses procedures or in later applications and use of higher energy. During the last decade research have been focussed on developing simple, clean, non-toxic, cost effective and eco-friendly protocols for synthesis of nanoparticles. In order to get this objective, biosynthesis methods have been developed in order to fill this gap. The biosynthesis of nanoparticles is simple, single step, eco-friendly and a green approach. The biochemical processes in biological agents reduce the dissolved metal ions into nano metals. The various biological agents like plant tissues, fungi, bacteria, etc. are used for biosynthesis for metal nanoparticles. In this review article, we summarised recent literature on biosynthesis of gold nanoparticles which have revolutionised technique of synthesis for their applications in different fields. Due to biocompatibility of gold nanoparticles, it has find its applications in biomedical applications. The protocol and mechanism of biosynthesis of gold nanoparticles along with various applications have also been discussed.

  18. iOS app development portable genius

    CERN Document Server

    Wentk, Richard

    2012-01-01

    The essential skills and technologies needed for iOS development in one handy guide! The unprecedented popularity of iOS devices, such as the iPhone, iPad, and iPod touch, has led to a development boom. If you’re eager to become part of the action, then this is the book for you! Packed with must-have information on iOS development, this handy guide covers Objective-C, Xcode, Frameworks, and sound design principles and explains how to upload an app to the app store and integrate apps with the latest advances that Apple offers developers. The featured tips and tricks will get you up and ru

  19. Erythrocentaurin, Biosynthesis Postulation and Biomimetic Synthesis

    Institute of Scientific and Technical Information of China (English)

    LEI,Jun; YUAN,Xiang-Hui; LIU,Zhu-Lan; LIU,Jian-Li

    2004-01-01

    @@ Erythrocentaurin is a relatively simple nature product isolated from the root of Gentiana macrophylla Pall.[1] The co-existed of gentiopicroside from the same species led to speculation that erythrocentaurin is a biosynthesis product of gentiopicroside. The transformation of secologanin to carbocyclic aglycone under biomimetic condition has already known (Scheme 1).[2,3] The postulated biosynthesis pathway of erythrocentaurin may be in the same way. In the process the cyclic hemiacetal of the aglycone opened to the dialdehyde which then undergoes a vinylogous aldol reaction, and then dehydroxylation and double bond migration to the title compound (Scheme 2).

  20. Nucleoside antibiotics: biosynthesis, regulation, and biotechnology.

    Science.gov (United States)

    Niu, Guoqing; Tan, Huarong

    2015-02-01

    The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply of new antibiotics. It is therefore of great importance to find and create new antibiotics. Nucleoside antibiotics are a large family of natural products with diverse biological functions. Their biosynthesis is a complex process through multistep enzymatic reactions and is subject to hierarchical regulation. Genetic and biochemical studies of the biosynthetic machinery have provided the basis for pathway engineering and combinatorial biosynthesis to create new or hybrid nucleoside antibiotics. Dissection of regulatory mechanisms is leading to strategies to increase the titer of bioactive nucleoside antibiotics.

  1. easyHealthApps: e-Health Apps dynamic generation for smartphones & tablets.

    Science.gov (United States)

    Paschou, Mersini; Sakkopoulos, Evangelos; Tsakalidis, Athanasios

    2013-06-01

    Mobile phones and especially smartphones have been embraced by a rapidly increasing number of people worldwide and this trend is expected to evolve even more in the years to come. There are numerous smartphone Apps that record critical medical data in an effort to solve a particular health issue each time. We studied such applications and not surprisingly, we have found that development and design effort is often repeated. Software patterns have been detected to exist, however re-usability has not been enforced. This leads to lost programming manpower and to increased probability of repeating bugs in Apps. Moreover, at the moment smartphone e-Health Apps demand time, effort and costs for development. Unfortunately even simple data recording Apps are practically impossible to be produced by multiple health domain users who are not developers. In this work, we propose, design and implement a simple and integrated solution which gives healthcare professionals and researchers the ability to create their own data intensive smartphone applications, independent of the desired healthcare domain. The proposed approach applies efficient software techniques that hide development from the users and enable App creation through a simple Web User Interface. The Apps produced are in native format and it is possible to dynamically receive m-Health business logic and the chosen UI. Evaluation of the proposed solution has shown that the generated Apps are functionally and UI equivalent to human-coded Apps according to a number of comparison parameters. Furthermore, e-Health professionals show particular interest in developing Apps on their own for a particular domain they focus on.

  2. User-Centered Design and Augmentative and Alternative Communication Apps for Children With Autism Spectrum Disorders

    Directory of Open Access Journals (Sweden)

    Margaret Lubas

    2014-05-01

    Full Text Available Communication difficulties are among the most frequent characteristics of children with autism spectrum disorders (ASD. Lack of communication can have a significant impact on the child’s life. Augmentative and alternative communication (AAC apps are a common form of AAC interventions that involve a combination of affordable technology with software that can be utilized to assist with communication. While AAC apps have been found to have some impact on improving the communication skills of children with ASD, current research exploring this topic is still limited. Focusing on the design process of AAC apps may provide better insight into improving clinical outcomes and user success. The user-centered design process incorporates a continuous cycle of user feedback to help inform and improve the functions and the capabilities of the technology, and it is an essential component in AAC app development. This article outlines how the user-centered design process could be adopted for the development of AAC apps for children with ASD.

  3. Review of Tour of the Nile [iPad App

    Directory of Open Access Journals (Sweden)

    Helen Strudwick

    2013-07-01

    Full Text Available A review of the iPad app, Tour of the Nile. The app promises 'a virtual journey along the Nile Valley' plus the chance to 'handle' objects through the technology of augmented reality.

  4. Using the FAIMS Mobile App for field data recording

    Science.gov (United States)

    Ballsun-Stanton, Brian; Klump, Jens; Ross, Shawn

    2016-04-01

    Multiple people creating data in the field poses a hard technical problem: our ``web 2.0'' environment presumes constant connectivity, data ``authority'' held by centralised servers, and sees mobile devices as tools for presentation rather than origination. A particular design challenge is the remoteness of the sampling locations, hundreds of kilometres away from network access. The alternative, however, is hand collection with a lengthy, error prone, and expensive digitisation process. This poster will present a field-tested open-source solution to field data recording. This solution, originally created by a community of archaeologists, needed to accommodate diverse recording methodologies. The community could not agree on standard vocabularies, workflows, attributes, or methodologies, but most agreed that at app to ``record data in the field'' was desirable. As a result, the app is generalised for field data collection; not only can it record a range of data types, but it is deeply customisable. The NeCTAR / ARC funded FAIMS Project, therefore, created an app which allows for arbitrary data collection in the field. In order to accomplish this ambitious goal, FAIMS relied heavily on OSS projects including: spatialite and gdal (for GIS support), sqlite (for a lightweight key-attribute-value datastore), Javarosa and Beanshell (for UI and scripting), Ruby, and Linux. Only by standing on the shoulders of giants, FAIMS was able to make a flexible and highly generalisable field data collection system that CSIRO geoscientists were able to customise to suit most of their completely unanticipated needs. While single-task apps (i.e. those commissioned by structural geologists to take strikes and dips) will excel in their domains, other geoscientists (palaeoecologists, palaeontologists, anyone taking samples) likely cannot afford to commission domain- and methodology-specific recording tools for their custom recording needs. FAIMS shows the utility of OSS software

  5. Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae.

    Science.gov (United States)

    Matsuno, Kiyoshi; Yamada, Yasuhiro; Lee, Chang-Kwon; Nihira, Takuya

    2004-01-01

    The Streptomyces virginiae gamma-butyrolactone autoregulator virginiae butanolide is a low-molecular-weight Streptomyces hormone eliciting virginiamycin biosynthesis through its binding to the specific receptor protein, BarA. Immediately downstream of barA lies barB, the transcription of which is tightly repressed by BarA in the absence of virginiae butanolide and derepressed in its presence. Thus, BarB is next to BarA on the virginiae butanolide-BarA signaling cascade. An in-frame 279-bp deletion was introduced into the barB allele, which rendered it inactive by eliminating the majority of the coding region, including the helix-turn-helix DNA-binding motif. No significant change was observed with the Delta barB mutant with respect to the timing or amount of virginiae butanolide production, or the morphological differentiation on solid media, indicating that barB neither participates in virginiae butanolide biosynthesis nor in cytodifferentiation. In contrast, analysis of virginiamycin production in the Delta barB mutant revealed that production of both virginiamycin M(1) and virginiamycin S occurred immediately after virginiae butanolide production, 2-3 h earlier than in the wild-type strain, indicating that BarB participates in the temporal retardation of virginiamycin production after virginiae butanolide inactivates the repressor function of BarA. RT-PCR analysis of the transcription of several genes surrounding barA-barB by the Delta barB mutant indicated that BarB plays a negative regulatory role, directly or indirectly, in the transcription of barZ, vmsR, and orf5 located upstream of barB.

  6. Creating iPhone Apps with Cocoa Touch

    CERN Document Server

    Hockenberry, Craig

    2010-01-01

    Creating iPhone Apps with Cocoa Touch: The Mini Missing Manual walks you through developing your first iPhone App and introduces you to your programming environments and tools: Cocoa Touch, Interface Builder, Xcode, and the Objective-C programming language. If you're a Java or C developer, this eBook is your fast track to App development. This eBook is adapted from parts of iPhone App Development: The Missing Manual.

  7. How to bring compute intensive C++ based apps to Android

    OpenAIRE

    Siggel, Martin

    2014-01-01

    You already have some C++ code for the desktop and you ever wanted to port this to Android? Then you should not wait to come to this talk. We'll guide you through the typical steps and pitfalls in this porting process using a demo application and our open source geometry app TiGL Viewer. The TiGL Viewer desktop application is used at the German Aerospace Center for aircraft design. It is mainly used to display 3D aircraft geometries, which are computed from a parametric description. The c...

  8. Data Exchanges in Mobile News Apps

    DEFF Research Database (Denmark)

    Kammer, Aske; Wallberg, Filip

    This paper maps the flows of data to and from third-party actors when users access content in mobile news apps. This way, it analyzes the strategic networks of collaboration and data exchange that news organizations engage in in the digital economy, expanding the traditional two-sided model...

  9. 77 FR 12796 - Commerce Business Apps Challenge

    Science.gov (United States)

    2012-03-02

    ... the public to develop, using at least one DOC data set, an application (Web, mobile, PC, etc.) that... Office of the Secretary Commerce Business Apps Challenge AGENCY: Office of the Secretary (OS), Department... help U.S. businesses grow and create jobs. Recently, the White House launched the...

  10. Motivating Instruction? There's an App for That!

    Science.gov (United States)

    Bruhn, Allison; Hirsch, Shanna; Vogelgesang, Kari

    2017-01-01

    Keeping students engaged in the curriculum is extremely important when attempting to close the achievement gap for students with and at risk for disabilities. This is particularly important for students with learning disabilities or behavior disorders. This article discusses the use of applications (apps) for mobile technologies that may be used…

  11. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Slot, Marie Falkesgaard; Bundsgaard, Jeppe; Gissel, Stig Toke

    2013-01-01

    Artiklen henvender sig til lærere og konsulenter, som ønsker at kvalificere deres fagsprog i arbejdet med apps og undervisningsdesign. Med udgangspunkt i læremiddeldidaktikken udpeger vi en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analysere og vurdere hvilke hand...

  12. Fra app'ernes planet til klasserummet

    DEFF Research Database (Denmark)

    Hansen, Thomas Illum; Slot, Marie Falkesgaard; Gissel, Stig Toke

    2013-01-01

    Artiklen henvender sig til lærere og konsulenter, som ønsker at kvalificere deres fagsprog i arbejdet med apps og undervisningsdesign. Med udgangspunkt i læremiddeldidaktikken udpeges en række kategorier og begreber, som læreren kan anvende i sit arbejde med at analyserer og vurderer hvilke handl...

  13. Web Content Flexibility through Mobile App

    Directory of Open Access Journals (Sweden)

    Sana Pathan

    2014-03-01

    Full Text Available E-commerce is very efficient & effective, but it needs programming knowledge to manage.many small organizations do not have human resource for this task and cannot support cost for hiring programmers or tech-support.thus, many applications providers create CMS apps to enable the e-commerce website to be created and with friendly UI. By developing iOS app WCFMA, it can handle this dynamic nature of content manipulation. WCFMA is specifically designed to enable non-technical users,to modify the existing contents as and when required in an intuitive and real-time fashion.and instead of downloading or capturing product images to be displayed on websites from separate camera devices,take it from the mobile device(iphone itself and edit the image like never before in the app and once done upload it on the web server. The website will fetch this updated images and display i tat an appropriate location.it will efficiently serve to dynamically manage websites of buisness whitch needs to change their web content at regular intervals where the owner or staff of the organization can handle their website from their iphone app.

  14. The App Squad: SLJ's Advisors Weigh in on Kids' Book Apps

    Science.gov (United States)

    Ishizuka, Kathy

    2011-01-01

    In this article, "School Library Journal's" ("SLJ") advisors talk about book apps for kids. They discuss what they like, what one should look for in discerning the best for kids and teens, and where this all might be headed.

  15. BIOSYNTHESIS OF YEAST CAROTENOIDS

    Science.gov (United States)

    Simpson, Kenneth L.; Nakayama, T. O. M.; Chichester, C. O.

    1964-01-01

    Simpson, Kenneth L. (University of California, Davis), T. O. M. Nakayama, and C. O. Chichester. Biosynthesis of yeast carotenoids. J. Bacteriol. 88:1688–1694. 1964.—The biosynthesis of carotenoids was followed in Rhodotorula glutinis and in a new strain, 62-506. The treatment of the growing cultures by methylheptenone, or ionone, vapors permitted observations of the intermediates in the biosynthetic pathway. On the basis of concentration changes and accumulation in blocked pathways, the sequence of carotenoid formation is postulated as phytoene, phytofluene, ζ-carotene, neurosporene, β-zeacarotene, γ-carotene, torulin, a C40 aldehyde, and torularhodin. Torulin and torularhodin were established as the main carotenoids of 62-506. PMID:14240958

  16. Xyloglucan and its biosynthesis

    Directory of Open Access Journals (Sweden)

    Olga A Zabotina

    2012-06-01

    Full Text Available The hemicellulosic polysaccharide xyloglucan (XyG, found in the primary cell walls of most plant tissues, is important for structural organization of the cell wall and regulation of growth and development. Significant recent progress in structural characterization of XyGs from different plant species has shed light on the diversification of XyG during plant evolution. Also, identification of XyG biosynthetic enzymes and examination of their interactions suggests the involvement of a multiprotein complex in XyG biosynthesis. This mini-review presents an updated overview of the diversity of XyG structures in plant taxa and recent findings on XyG biosynthesis.

  17. English Language Teaching Apps: Positioning Parents and Young Learners

    Science.gov (United States)

    Chik, Alice

    2014-01-01

    Since the introduction of iPads in 2010, the sales of tablet computers and mobile applications (apps) have grown exponentially. iPads and other tablets are marketed as learning tools, and many apps target learners as young as six months old. This article reports on a research project examining the unique features of English learning apps based on…

  18. Hippocampal network oscillations in APP/APLP2-deficient mice.

    Directory of Open Access Journals (Sweden)

    Xiaomin Zhang

    Full Text Available The physiological function of amyloid precursor protein (APP and its two homologues APP-like protein 1 (APLP1 and 2 (APLP2 is largely unknown. Previous work suggests that lack of APP or APLP2 impairs synaptic plasticity and spatial learning. There is, however, almost no data on the role of APP or APLP at the network level which forms a critical interface between cellular functions and behavior. We have therefore investigated memory-related synaptic and network functions in hippocampal slices from three lines of transgenic mice: APPsα-KI (mice expressing extracellular fragment of APP, corresponding to the secreted APPsα ectodomain, APLP2-KO, and combined APPsα-KI/APLP2-KO (APPsα-DM for "double mutants". We analyzed two prominent patterns of network activity, gamma oscillations and sharp-wave ripple complexes (SPW-R. Both patterns were generally preserved in all strains. We find, however, a significantly reduced frequency of gamma oscillations in CA3 of APLP2-KO mice in comparison to APPsα-KI and WT mice. Network activity, basic synaptic transmission and short-term plasticity were unaltered in the combined mutants (APPsα-DM which showed, however, reduced long-term potentiation (LTP. Together, our data indicate that APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations.

  19. App de Citas Médicas desarrollada en Android

    OpenAIRE

    Cantallops Cifre, Francesc

    2017-01-01

    App de Citas Médicas desarrollada en Android que consume datos através de un WebService Medical Dating app developed on Android that consumes data through a WebService App de Cites Mèdiques desenvolupat en Android que consumeix dades a través d'un WebService

  20. Cleaning up That Mess: A Framework for Classifying Educational Apps

    Science.gov (United States)

    Cherner, Todd; Dix , Judy; Lee, Corey

    2014-01-01

    As tablet technologies continue to evolve, the emergence of educational applications (apps) is impacting the work of teacher educators. Beyond online lists of best apps for education and recommendations from colleagues, teacher educators have few resources available to support their teaching of how to select educational apps. In response, this…

  1. Educational Behavior Apps and Wearable Devices: Current Research and Prospects

    Science.gov (United States)

    Lowe, Heather

    2016-01-01

    Dartmouth and MIT have developed educational behavior apps and wearable devices that collect contiguous streams of data from student users. Given the consent of the user, the app collects information about a student's physical activity, sleep patterns, and location to form conjectures about social and academic behavior. These apps have the…

  2. Live Speed Analysis, en app til hastighedsmålinger

    DEFF Research Database (Denmark)

    Bolet, Lars; Christensen, Peter Muhlig; Halskov-Sørensen, Asbjørn;

    2013-01-01

    I et bachelorprojekt har tre studerende udviklet en app, som kan registrere og behandle hastigheder ved den såkaldte spejlmetode. App'en er siden videreudviklet, så registreringerne stedfæstes, tidstemples og uploades til en fæIIes database. App'en er frit tilgængelig. Den kan bruges af...

  3. Using the Modern Technology That Is the "App"

    Science.gov (United States)

    Bernardelli, Alessio

    2013-01-01

    A few years ago, the sight of the letters APP would have made teachers in England think of the Assessing Pupils' Progress assessment approach introduced by the government. Now, when they see those same letters they mostly think about smartphone and tablet applications, shortened to "apps." With the thousands of apps available in the…

  4. Athletic Training Education: There's an App for That

    Science.gov (United States)

    Keeley, Kim; Potteiger, Kelly; Brown, Christopher D.

    2015-01-01

    Context: Mobile applications (apps) are growing in popularity due to the increased use of smartphones. Many available apps are educational in nature and may provide both students and educators freedom for learning to occur outside of the typical classroom environment. Objective: To provide a description of relevant apps along with a brief synopsis…

  5. e-Medication met behulp van apps : Gebruik en gebruikerservaringen

    NARCIS (Netherlands)

    van Kerkhof LWM; van de Laar K; Schooneveldt B; Hegger I; EVG; V& Z

    2015-01-01

    De afgelopen jaren zijn er veel apps voor het gebruik van medicijnen beschikbaar gekomen, voor zowel professionals als burgers. In hoeverre deze apps worden gewaardeerd, hangt vooral af van het gebruiksgemak. Dit blijkt uit onderzoek van het RIVM onder gebruikers van apps die voor diabetici en anest

  6. Low-Budget Apps for Students of All Abilities

    Science.gov (United States)

    VanWeelden, Kimberly; Heath, Julia

    2013-01-01

    With more than 850,000 apps currently on the market, there are multiple apps that can be used to help all students in music education, particularly those with special needs. This article lists low-budget apps useful for the elementary or secondary general music classroom.

  7. Using Apps to Support Disciplinary Literacy and Science Learning

    Science.gov (United States)

    Castek, Jill; Beach, Richard

    2013-01-01

    Apps, specialized programs used on mobile computers, can be used in innovative ways to enhance science and literacy learning. With the skilled guidance of their teachers, students can exploit app affordances for learning and acquire disciplinary literacies unique to science. This article showcases apps that help students to access information,…

  8. Apps and eating disorders: A systematic clinical appraisal

    Science.gov (United States)

    Rothwell, Emily R.

    2015-01-01

    ABSTRACT Objective Smartphone applications (apps) are proliferating and health‐related apps are particularly popular. The aim of this study was to identify, characterize, and evaluate the clinical utility of apps designed either for people with eating disorders or for eating disorder professionals. Method A search of the major app stores identified 805 potentially relevant apps, of which 39 were primarily designed for people with eating disorders and five for professionals. Results The apps for people with eating disorders had four main functions. Most common was the provision of advice, the quality of which ranged from sound to potentially harmful. Five apps included self‐assessment tools but only two used methods that would generally be viewed as reliable. Four apps had the self‐monitoring of eating habits as a major feature. Entering information into these apps could be accomplished with varying degrees of ease, but viewing it was more difficult. One app allowed the transfer of information between patients and clinicians. Discussion The enthusiasm for apps outstrips the evidence supporting their use. Given their popularity, it is suggested that clinicians evaluate app use as part of routine assessment. The clinical utility of the existing apps is not clear. Some are capable of tracking key features over time, but none has the functions required for analytic self‐monitoring as in cognitive behavioral treatments. The full potential of apps has yet to be realized. Specialized apps could be designed to augment various forms of treatment, and there is the possibility that they could deliver an entire personalized intervention. © 2015 The Authors. International Journal of Eating Disorders published by Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:1038–1046) PMID:25728705

  9. Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.

    Science.gov (United States)

    Borreca, Antonella; Gironi, Katia; Amadoro, Giusy; Ammassari-Teule, Martine

    2016-07-01

    Amyloid precursor protein (APP) is overexpressed in familiar and sporadic Alzheimer Disease (AD) patients suggesting that, in addition to abnormalities in APP cleavage, enhanced levels of APP full length might contribute to the pathology. Based on data showing that the two RNA binding proteins (RBPs), Fragile-X Mental Retardation Protein (FMRP) and heteronuclear Ribonucleoprotein C (hnRNP C), exert an opposite control on APP translation, we have analyzed whether expression and translation of these two RBPs vary in relation to changes in APP protein and mRNA levels in the AD brain at 1, 3, and 6 months of age. Here, we show that, as expected, human APP is overexpressed in hippocampal total extract from Tg2576 mice at all age points. APP overexpression, however, is not stable over time but reaches its maximal level in 1-month-old mutants in association with the stronger (i) reduction of FMRP and (ii) augmentation of hnRNP C. APP levels then decrease progressively as a function of age in close relationship with the gradual normalization of FMRP and hnRNP C levels. Consistent with the mouse data, expression of FMRP and hnRNP C are, respectively, decreased and increased in hippocampal synaptosomes from sporadic AD patients. Our findings identify two RBP targets that might be manipulated for reducing abnormally elevated levels of APP in the AD brain, with the hypothesis that acting upstream of amyloidogenic processing might contribute to attenuate the amyloid burden.

  10. Model for implementing cognitive behavioural therapy for smartphone app based smoking cessation program

    Directory of Open Access Journals (Sweden)

    Abdullah Alsharif

    2015-11-01

    Full Text Available Smoking cessation programs are widely implemented to assist smokers in the process of quitting smoking. Cognitive Behavioural Therapy (CBT is a psychological approach that is increasingly used in smoking cessation programs. CBT has also been implemented for smoking cessation programs and has been successful in helping smokers to quit. Another advantage of CBT is that it can be combined with different tools and technologies and hence made to deliver effective health intervention programs. The recent advancements in smartphone technologies have been widely explored to develop smoking cessation apps as tools to assist with quitting smoking. However, most existing smartphone apps lack follow-up and adherence to clinical guidelines for treatment. To date, there are no studies which have explored implementing CBT modules into smoking cessation apps. Therefore, there is a need for implementing behavioural change mechanisms in smoking cessation apps to help smokers quit effectively. In this study, we propose a new approach that combines mobile health technology and CBT methods to provide an effective smoking cessation program. The ubiquitous presence of smartphones and the various communication benefits they provide are utilized by our proposed system to provide a CBT paradigm into smoking cessation app systems and hence enhance their success potential. Currently, the proposed system is at the implementation stage, which is soon to be followed by a clinical trial to study the impact of this system on smoking cessation.

  11. Safety as Net Work: “Apps Against Abuse” and the Digital Labour of Sexual Assault Prevention

    Directory of Open Access Journals (Sweden)

    Brian Beaton

    2015-05-01

    Full Text Available This study examines the results of the 2011 “Apps Against Abuse” app development challenge that was held through Challenge.gov, a popular U.S. government crowdsourcing platform. It highlights promising attributes of the resulting applications, with a focus on their social networking capabilities and the idea of instant evidence. It also highlights troubling aspects of the resulting applications, with a focus on issues of labour, surveillance, and interpersonal judgment. The larger purpose of the study is to begin the work of determining how the resulting applications from the “Apps Against Abuse” app development challenge came to include their specific mix of design features and qualities. Possible influences on the “Apps Against Abuse” app developer crowd include the contest guidelines and framings, but also pre-existing personal security practices. Both are examined in detail. The larger argument put forth is that the “Apps Against Abuse” app developer crowd seems to have been operating inside a general design pathway established by the “Apps Against Abuse” competition but also relatively “on its own” in terms of the crowd’s research and design process. The result of which was a set of applications that promote and encourage a new form of bioconvergence between information, technology, and people—one that de-emphasizes personal vigilance and preparedness, hallmarks of earlier women’s “self-defence” culture, in favour of having users create a networked, “crowd-sourced self.”

  12. App Reviews: Breaking the User and Developer Language Barrier

    KAUST Repository

    Hoon, Leonard

    2015-10-22

    Apple, Google and third party developers offer apps across over twenty categories for various smart mobile devices. Offered exclusively through the App Store and Google Play, each app allows users to review the app and their experience with it. Current literature offers a general statistical picture of these reviews, and a broad overview of the nature of discontent of apps. However, we do not yet have a good framework to classify user reviews against known software quality attributes like performance or usability. In order to close this gap, in this paper, we develop an ontology encompassing software attributes derived from software quality models. This decomposes into approximately five thousand words that users employ to review apps. By identifying a consistent set of vocabulary that users communicate with, we can sanitise large datasets to extract stakeholder actionable information from reviews. The findings offered in this paper assists future app review analysis by bridging end-user communication and software engineering vocabulary.

  13. Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

    Energy Technology Data Exchange (ETDEWEB)

    Kosicek, Marko, E-mail: marko.kosicek@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia); Malnar, Martina, E-mail: martina.malnar@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia); Goate, Alison, E-mail: goate@icarus.wustl.edu [Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110 (United States); Hecimovic, Silva, E-mail: silva.hecimovic@irb.hr [Division of Molecular Medicine, Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb (Croatia)

    2010-03-12

    It has been suggested that cholesterol may modulate amyloid-{beta} (A{beta}) formation, a causative factor of Alzheimer's disease (AD), by regulating distribution of the three key proteins in the pathogenesis of AD ({beta}-amyloid precursor protein (APP), {beta}-secretase (BACE1) and/or presenilin 1 (PS1)) within lipid rafts. In this work we tested whether cholesterol accumulation upon NPC1 dysfunction, which causes Niemann Pick type C disease (NPC), causes increased partitioning of APP into lipid rafts leading to increased CTF/A{beta} formation in these cholesterol-rich membrane microdomains. To test this we used CHO NPC1{sup -/-} cells (NPC cells) and parental CHOwt cells. By sucrose density gradient centrifugation we observed a shift in fl-APP/CTF compartmentalization into lipid raft fractions upon cholesterol accumulation in NPC vs. wt cells. Furthermore, {gamma}-secretase inhibitor treatment significantly increased fl-APP/CTF distribution in raft fractions in NPC vs. wt cells, suggesting that upon cholesterol accumulation in NPC1-null cells increased formation of APP-CTF and its increased processing towards A{beta} occurs in lipid rafts. Our results support that cholesterol overload, such as in NPC disease, leads to increased partitioning of APP/CTF into lipid rafts resulting in increased amyloidogenic processing of APP in these cholesterol-rich membranes. This work adds to the mechanism of the cholesterol-effect on APP processing and the pathogenesis of Alzheimer's disease and supports the role of lipid rafts in these processes.

  14. THELMA: a mobile app for crowdsourcing environmental data

    Science.gov (United States)

    Hintz, Kenneth J.; Hintz, Christopher J.; Almomen, Faris; Adounvo, Christian; D'Amato, Michael

    2014-06-01

    The collection of environmental light pollution data related to sea turtle nesting sites is a laborious and time consuming effort entailing the use of several pieces of measurement equipment, their transportation and calibration, the manual logging of results in the field, and subsequent transfer of the data to a computer for post-collection analysis. Serendipitously, the current generation of mobile smart phones (e.g., iPhone® 5) contains the requisite measurement capability, namely location data in aided GPS coordinates, magnetic compass heading, and elevation at the time an image is taken, image parameter data, and the image itself. The Turtle Habitat Environmental Light Measurement App (THELMA) is a mobile phone app whose graphical user interface (GUI) guides an untrained user through the image acquisition process in order to capture 360° of images with pointing guidance. It subsequently uploads the user-tagged images, all of the associated image parameters, and position, azimuth, elevation metadata to a central internet repository. Provision is also made for the capture of calibration images and the review of images before upload. THELMA allows for inexpensive, highly-efficient, worldwide crowdsourcing of calibratable beachfront lighting/light pollution data collected by untrained volunteers. This data can be later processed, analyzed, and used by scientists conducting sea turtle conservation in order to identify beach locations with hazardous levels of light pollution that may alter sea turtle behavior and necessitate human intervention after hatchling emergence.

  15. Apps for People With Rheumatoid Arthritis to Monitor Their Disease Activity: A Review of Apps for Best Practice and Quality

    Science.gov (United States)

    Townsley, Hermaleigh; White, Bonnie; Langlotz, Tobias; Taylor, William J

    2017-01-01

    Background Rheumatoid arthritis (RA) is a chronic inflammatory arthritis requiring long-term treatment with regular monitoring by a rheumatologist to achieve good health outcomes. Since people with RA may wish to monitor their own disease activity with a smartphone app, it is important to understand the functions and quality of apps for this purpose. Objective The aim of our study was to assess the features and quality of apps to assist people to monitor their RA disease activity by (1) summarizing the available apps, particularly the instruments used for measurement of RA disease activity; (2) comparing the app features with American College of Rheumatology and European League against Rheumatism (ACR and EULAR) guidelines for monitoring of RA disease activity; and (3) rating app quality with the Mobile App Rating Scale (MARS). Methods Systematic searches of the New Zealand iTunes and Google Play app stores were used to identify all apps for monitoring of RA disease activity that could be used by people with RA. The apps were described by both key metadata and app functionality. App adherence with recommendations for monitoring of RA disease activity in clinical practice was evaluated by identifying whether apps included calculation of a validated composite disease activity measure and recorded results for future retrieval. App quality was assessed by 2 independent reviewers using the MARS. Results The search identified 721 apps in the Google Play store and 216 in the iTunes store, of which 19 unique apps met criteria for inclusion (8 from both app stores, 8 iTunes, and 3 Google Play). In total, 14 apps included at least one validated instrument measuring RA disease activity; 7 of 11 apps that allowed users to enter a joint count used the standard 28 swollen and tender joint count; 8 apps included at least one ACR and EULAR-recommended RA composite disease activity (CDA) measure; and 10 apps included data storage and retrieval. Only 1 app, Arthritis Power, included

  16. The iPhone app design manual create perfect designs for effortless coding and app store success

    CERN Document Server

    Brown, Dave

    2014-01-01

    App creation is now a huge, global business, with hundreds of thousands of developers, entrepreneurs, and companies attracted by the potential rewards. But games, functional apps, and promotional apps alike depend on attractive, intuitive design for their appeal, and most fail to find a significant audience. With this book, you'll be able to turn your great app idea into a functioning design ready for coding, or apply graphic design skills to this exciting new field, and create an app that will stand out in a market that is worth over a billion dollars every year. Understand the design proc

  17. Bile acid biosynthesis and its regulation

    Directory of Open Access Journals (Sweden)

    Areta Hebanowska

    2010-10-01

    Full Text Available Bile acid biosynthesis is the main pathway of cholesterol catabolism. Bile acids are more soluble than cholesterol so are easier to excrete. As amphipathic molecules they participate in lipid digestion and absorption in the intestine and they help to excrete free cholesterol with bile. They are also ligands for nuclear receptors regulating the expression of genes involved in cholesterol metabolism. Interconversion of cholesterol into bile acids is an important point of its homeostasis. Seventeen enzymes are engaged in this process and many of them are cytochromes P450. Bile acid synthesis initiation may proceed with the “classical” pathway (starting with cholesterol hydroxylation at the C7α position or the “alternative” pathway (starting with cholesterol hydroxylation at the C27 position. Two additional pathways are possible, though their quantitative significance is small (initiated with cholesterol hydroxylations of C24 and C25 positions. Oxysterols produced are not only intermediates of bile acid biosynthesis but also important regulators of metabolism. Bile acid biosynthesis takes place in the liver, but some enzymes are also present in other organs, where they participate in regulation of cholesterol metabolism. Those enzymes are potential targets for new drugs against cholesterol metabolism disturbances. This article is a brief description of the bile acid biosynthesis pathway and participating enzymes.

  18. A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.

    Science.gov (United States)

    Di Fede, Giuseppe; Catania, Marcella; Morbin, Michela; Rossi, Giacomina; Suardi, Silvia; Mazzoleni, Giulia; Merlin, Marco; Giovagnoli, Anna Rita; Prioni, Sara; Erbetta, Alessandra; Falcone, Chiara; Gobbi, Marco; Colombo, Laura; Bastone, Antonio; Beeg, Marten; Manzoni, Claudia; Francescucci, Bruna; Spagnoli, Alberto; Cantù, Laura; Del Favero, Elena; Levy, Efrat; Salmona, Mario; Tagliavini, Fabrizio

    2009-03-13

    beta-Amyloid precursor protein (APP) mutations cause familial Alzheimer's disease with nearly complete penetrance. We found an APP mutation [alanine-673-->valine-673 (A673V)] that causes disease only in the homozygous state, whereas heterozygous carriers were unaffected, consistent with a recessive Mendelian trait of inheritance. The A673V mutation affected APP processing, resulting in enhanced beta-amyloid (Abeta) production and formation of amyloid fibrils in vitro. Co-incubation of mutated and wild-type peptides conferred instability on Abeta aggregates and inhibited amyloidogenesis and neurotoxicity. The highly amyloidogenic effect of the A673V mutation in the homozygous state and its anti-amyloidogenic effect in the heterozygous state account for the autosomal recessive pattern of inheritance and have implications for genetic screening and the potential treatment of Alzheimer's disease.

  19. The mediatization of public sex cultures in the case of the hook-up app Grindr

    DEFF Research Database (Denmark)

    Jørgensen, Kristian Møller

    The mediatization of public sex cultures in the case of the hook-up app Grindr Along with the normalisation of geo-locative dating and hook-up practices in mainstream publics – through apps like Tinder, Bumble and Happn – imaginations of sexual privacy and indeed publicness seem to be changing...... as the life practices in which they become integral, are addressed. It is argued that mediatization processes mold public sex cultures and non-monogamous relationships in similar ways. Conversely I argue that hook-up apps are simultaneously molded by the cultural systems that they enter. The nudging towards...... certain actions in the affordance structure is taken up or pushed against in ways that reflect the users’ biographically anchored value systems. Theoretically the paper draws on both cultural and material perspectives on mediatization (Lundby, 2014). André Jansson’s division of mediatization into three...

  20. Combining apps targeting professionals and senior citizens to improve housing accessibility and influence housing provision policies

    DEFF Research Database (Denmark)

    Helle, Tina; Iwarsson, Susanne; Lunn, Tine Bieber;

    2015-01-01

    Two separate apps that address the increasingly important issue of accessible housing for senior citizens have been developed in different project settings. One of the apps was developed to facilitate the process for professional raters to assess housing accessibility in the context of individual...... and desires, and for senior citizens to benefit by getting access to a database of professionally rated dwellings. The ultimate goal is the generation of sound knowledge reflecting the needs and desires of senior citizens and professional requirements regarding accessible housing as a means to inform...

  1. Audio App Brings a Better Nights Sleep

    Science.gov (United States)

    2015-01-01

    Neuroscientist Seth Horowitz was part of a NASA-funded team at State University of New York Stony Brook demonstrating that low-amplitude vestibular stimulation could induce sleep. After recognizing the same stimulation could be applied through sound, Horowitz founded Sleep Genius, located in Park City, Utah, and released a mobile app of the same name that helps people to get a more restful sleep.

  2. No app for that? Make it yourself!

    CERN Multimedia

    CERN Bulletin

    2012-01-01

    Are you passionate about science? Do you like communicating that passion to the general public? Then come along to the very first CERN Summer Student Webfest kicking off on Friday 3 August! The Webfest is a grassroots initiative by the summer students, seeking to spark new ideas that could innovate the future of web-based education about CERN, the LHC and particle physics.   The CERN Summer Student Webfest is a weekend of online web-based creativity modelled on the gatherings (sometimes called hackfests or hackathons) that energize many open source communities. You can work with like-minded students and CERN staff to design and build demos of the web apps you would like to see online. Prizes will be awarded to the best apps, with a Grand Prize winner receiving a trip to the Mozilla Festival in London! Participants in the CERN Summer Student Webfest will work in teams and design neat web apps that encourage the public to learn more about science and, in particular, CERN, the LHC and particle physi...

  3. APP as a Protective Factor in Acute Neuronal Insults

    Science.gov (United States)

    Hefter, Dimitri; Draguhn, Andreas

    2017-01-01

    Despite its key role in the molecular pathology of Alzheimer’s disease (AD), the physiological function of amyloid precursor protein (APP) is unknown. Increasing evidence, however, points towards a neuroprotective role of this membrane protein in situations of metabolic stress. A key observation is the up-regulation of APP following acute (stroke, cardiac arrest) or chronic (cerebrovascular disease) hypoxic-ischemic conditions. While this mechanism may increase the risk or severity of AD, APP by itself or its soluble extracellular fragment APPsα can promote neuronal survival. Indeed, different animal models of acute hypoxia-ischemia, traumatic brain injury (TBI) and excitotoxicity have revealed protective effects of APP or APPsα. The underlying mechanisms involve APP-mediated regulation of calcium homeostasis via NMDA receptors (NMDAR), voltage-gated calcium channels (VGCC) or internal calcium stores. In addition, APP affects the expression of survival- or apoptosis-related genes as well as neurotrophic factors. In this review, we summarize the current understanding of the neuroprotective role of APP and APPsα and possible implications for future research and new therapeutic strategies. PMID:28210211

  4. Development of a smartphone app for adolescents with lupus: a collaborative meeting-based methodology inclusive of a wide range of stakeholders.

    Science.gov (United States)

    Herschman, Jessica; Kasenberg, Todd; Levy, Deborah; Ruth, Natasha; Taberner, Christy; Kaufman, Miriam; Regina, Andrea

    2014-01-01

    Traditional challenges of creating a medical app include hearing the voices of various stakeholders as a collective rather than in a consultative process that is sequential. This report describes the development of a mobile (smartphone) app for adolescents with lupus as well as the process that was used to overcome the challenge described above. The development of the smartphone app addressed optimal ways to incorporate information about 1) lupus, including the effects of both the disease and the medications used to treat it; 2) how life choices can affect lupus patients' condition; and 3) ways to increase self-management and communication. The collaborative concept-generating and requirements-gathering methodology was used during a two-day workshop with a range of stakeholders (ages 16 - 59 years) that focused on leveraging user-centered design methods to generate guidance to mobile app developers. The app development process conducted during the workshop included the following steps: 1) recruiting a goal-focused collaborative group, 2) defining app objectives, 3) evaluating potential needs of users, 4) brainstorming app features and use-case modeling, 5) reviewing existing app features and prototypes, 6) refining functionalities, 7) writing user narratives, 8) visualizing navigation and feature design, and 9) identifying content. The use of creative devices such as drawing interfaces fostered fun, engagement, and sustained energy, and the use of a brainstorming technique leveraged methods that ensured an inclusive process so that even participants who were shy, quiet, or easily intimidated by "professionals" felt confident to contribute. In addition to a name change for the app, project outcomes included the selection of the following app features: symptom tracking; appointment and medication reminders; a social media component; a medical summary; easy navigation; informational content; gamification; and personalization (options for customization).

  5. Upstream regulation of mycotoxin biosynthesis.

    Science.gov (United States)

    Alkhayyat, Fahad; Yu, Jae-Hyuk

    2014-01-01

    Mycotoxins are natural contaminants of food and feed products, posing a substantial health risk to humans and animals throughout the world. A plethora of filamentous fungi has been identified as mycotoxin producers and most of these fungal species belong to the genera Aspergillus, Fusarium, and Penicillium. A number of studies have been conducted to better understand the molecular mechanisms of biosynthesis of key mycotoxins and the regulatory cascades controlling toxigenesis. In many cases, the mycotoxin biosynthetic genes are clustered and regulated by one or more pathway-specific transcription factor(s). In addition, as biosynthesis of many secondary metabolites is coordinated with fungal growth and development, there are a number of upstream regulators affecting biosynthesis of mycotoxins in fungi. This review presents a concise summary of the regulation of mycotoxin biosynthesis, focusing on the roles of the upstream regulatory elements governing biosynthesis of aflatoxin and sterigmatocystin in Aspergillus.

  6. Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum

    OpenAIRE

    Kulis-Horn, Robert K; Persicke, Marcus; Kalinowski, Jörn

    2013-01-01

    l-Histidine biosynthesis is an ancient metabolic pathway present in bacteria, archaea, lower eukaryotes, and plants. For decades l-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria. Furthermore, in the last 15 years this pathway has been also investigated intensively in the industrial amino acid-producing bacterium Corynebacterium glutamicum, revealing similarities to E. coli and S. typhimurium...

  7. PoliticAPP: Towards a Categorization of Mobile Apps in Political Communication

    Directory of Open Access Journals (Sweden)

    Pablo VÁZQUEZ SANDE

    2016-06-01

    Full Text Available This article is an analyze of all mobile apps that are available in the field of Spanish political communication, with the aim to develop a pioneering categorization of these platforms according to various criteria as promoters, aims pursued or areas of performance. It includes also a critical review from which it is concluded that these app reproduce classic communication patterns with the voters. That means that the implementation of these channels seems to have been due more to political marketing than to boost democratic participation or to introduce an horizontal outline of a new relationship between politicians and citizens.

  8. In-Application Payment from Mobile Apps : A study of In-App Payment

    OpenAIRE

    Haines, Jøran Christiansen; Hanssen, Alexander

    2013-01-01

    The main purpose of this thesis is to evaluate and compare existing serviceproviders of in-app payment solutions and their APIs, and then concludewhat would be the best choice for hobby developers when deciding on whatservice provider to use for their application.We gained hands-on experience by developing a simple Quiz game appthat featured the implementation of in-app purchase. We took a look atthe major service providers; Apple, Google, PayPal and Windows to getrelevant information and eva...

  9. Development and Testing of a Mobile Phone App for Self-Monitoring of Calcium Intake in Young Women

    Science.gov (United States)

    Tay, Ilona

    2017-01-01

    Background Interventions to prevent osteoporosis by increasing dairy intake or physical activity in young women have been limited to increasing osteoporosis knowledge and awareness. However, findings have shown that this does not always lead to a change in behaviors. Self-monitoring using mobile devices in behavioral interventions has yielded significant and positive outcomes. Yet, to our knowledge, mobile self-monitoring has not been used as an intervention strategy to increase calcium intake, particularly in young women, for better bone health outcomes. Objective As development and testing of mobile app–based interventions requires a sequence of steps, our study focused on testing the acceptability and usability of Calci-app, a dietary app to self-monitor calcium consumption, before it is used in a behavioral change intervention in young women aged 18-25 years. Methods Calci-app development followed 4 steps: (1) conceptualization, (2) development and pretesting, (3) pilot testing, and (4) mixed methods evaluation. Results We present the development process of Calci-app and evaluation of the acceptability and usability of the app in young women. Overall, 78% (31/40) of study participants completed the 5-day food record with high compliance levels (defined as more than 3 days of full or partial completion). There was a significant reduction in the proportion of participants completing all meal entries over the 5 days (P=.01). Participants generally found Calci-app easy and convenient to use, but it was time-consuming and they expressed a lack of motivation to use the app. Conclusions We present a detailed description of the development process of Calci-app and an evaluation of its usability and acceptability to self-monitor dietary calcium intake. The findings from this preliminary study demonstrated acceptable use of Calci-app to self-monitor calcium consumption. However, for regular and long-term use the self-monitoring function in Calci-app could be expanded

  10. 外源性H2S通过调节β-位淀粉样前体蛋白裂解酶1表达对PC12细胞APP/Ap代谢的影响%Effect of Exogenous Hydrogen Sulfide on Amyloid Precursor Protein/β-amyloid Processing Through Regulating Expression of β-site Amyloid Precursor Protein Cleaving Enzyme 1 in Pheochromocytoma Cells

    Institute of Scientific and Technical Information of China (English)

    代政伟; 孟涛; 晏勇

    2011-01-01

    目的 观察外源性硫化氮对啥格细胞瘤细胞p一位淀粉样前体蛋白裂解酶1(BACE1)的调节作用,进而探讨其对淀粉样前体蛋白/β-位淀粉样蛋白代谢途径的影响.方法 用硫氮化钠作外源性HZS供体,实脸设空白对照组、NaHS 50 μmol/L组、NaHS 100μmol/L组和NaHS 200 μmol/L组,按分组浓度处理PC12细胞24 h后,RT-PCR和Western blot法检测细胞内BACEI mRNA及蛋白表达,并用Western blot法继而检测APP代谢过程中关健蛋白APP,C99,C83表达变化,ELISA法检浏细胞培养液中Aβ40和Aβ42水平.结果 NaHS在实脸浓度范围内从基因与蛋白两个水平上呈剂量依赖性下调BACEI表达,并下调C99,Aβ40和Aβ42蛋白表达,上调C83蛋白,各NaHS组分别与对照组比校,差别均有统计学意义(P0.05).结论 外源性HZS具有通过调节PC12细胞BACEI表达下调APP/Ap代谢的作用.%Objective To observe the effect of exogenous hydrogen sulfide on β-site amyioid precursor protein cleaving enzyme 1 ( BACE1 ) and the amyloid precursor protein/β-amyloid (APP/Aβ) processing in pheochromocytoma (PC12) cells. Methods PC12 cells were divided into 4 groups:blank control group,NaHS 50 μmol/L group, NaHS100 μmol/L group and NaHS 200 .μmol/L group. Four groups were treated with 0,50,100 or 200 μmol/L sodium hydrosulfide( NaHS, the homer of exogenous hydrogen sulfide ), respectively. RT-PCR and Western blot were used to detect the levels of BACE1 mRNA and protein expression. Western blot was also used to detect the levels of key proteins in the metabolic process of APP,including APP,C99 and C83. ELISA method was used to analyze the levels of Aβ40 and Aβ42 in cellular culture medium. Results Compared with blank control group, NaHS significantly and dose-dependently decreased BACE1 mRNA and protein expression within experimental concentration rages in NaHS groups. So did the C99, Aβ40 and Aβ42 proteins( all P < 0. 05 ). On the contrary, C83 protein significantly increased

  11. Engineering stories? A narratological approach to children's book apps

    Directory of Open Access Journals (Sweden)

    Hadassah Stichnothe

    2014-01-01

    Full Text Available With the rise of smartphones and tablet pcs, children's book apps have emerged as a new type of children's media. While some of them are based on popular children's books such as Mo Willems’ Pigeon books or Beatrix Potter's Peter Rabbit, others were specifically designed as apps. This paper focuses on examining book apps under the aspects of implied user strategies and narrative structure. Using a narratological framework that also takes into account the unique characteristics of the medium, a terminology for the analysis of book apps will be sketched out. Furthermore, an exemplary analysis of iOS books apps for pre- and grade school children comes to the conclusion that, far from offering the child users room for individual creativity, a large number of apps rather train their users in following prescribed paths of reading.

  12. Microbial biosynthesis of alkanes.

    Science.gov (United States)

    Schirmer, Andreas; Rude, Mathew A; Li, Xuezhi; Popova, Emanuela; del Cardayre, Stephen B

    2010-07-30

    Alkanes, the major constituents of gasoline, diesel, and jet fuel, are naturally produced by diverse species; however, the genetics and biochemistry behind this biology have remained elusive. Here we describe the discovery of an alkane biosynthesis pathway from cyanobacteria. The pathway consists of an acyl-acyl carrier protein reductase and an aldehyde decarbonylase, which together convert intermediates of fatty acid metabolism to alkanes and alkenes. The aldehyde decarbonylase is related to the broadly functional nonheme diiron enzymes. Heterologous expression of the alkane operon in Escherichia coli leads to the production and secretion of C13 to C17 mixtures of alkanes and alkenes. These genes and enzymes can now be leveraged for the simple and direct conversion of renewable raw materials to fungible hydrocarbon fuels.

  13. Engineering of Glucosinolate Biosynthesis

    DEFF Research Database (Denmark)

    Møldrup, Morten Emil; Salomonsen, Bo; Halkier, Barbara Ann

    2012-01-01

    -efficient methods for identification and validation of candidate genes are needed. This chapter covers the methodology we are using for gene discovery in glucosinolate engineering, namely, guilt-by-association-based in silico methods and fast proof-of-function screens by transient expression in Nicotiana...... of glucosinolate biosynthesis, although in planta validation of candidate gene function often is hampered by time-consuming generation of knockout and overexpression lines in Arabidopsis. To better exploit the increasing amount of data available from genomic sequencing, microarray database and RNAseq, time...... benthamiana. Moreover,the lessons learned in the rapid, transient tobacco system are readily translated to our robust, versatile yeast expression platform, where additional genes critical for large-scale microbial production of glucosinolates can be identified. We anticipate that the methodology presented...

  14. Microbial biosynthesis of nontoxic gold nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Roy, Swarup, E-mail: swaruproy@klyuniv.ac.in [Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal (India); Das, Tapan Kumar [Department of Biochemistry and Biophysics, University of Kalyani, Kalyani 741235, West Bengal (India); Maiti, Guru Prasad [Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, West Bengal (India); Department of Anesthesiology, Texas Tech University Health science Center, 3601 4th Street, Lubbock, TX 79430 (United States); Basu, Utpal [Department of Molecular Biology and Biotechnology, University of Kalyani, Kalyani 741235, West Bengal (India)

    2016-01-15

    Graphical abstract: The manuscript deals with the fungus mediated optimized biologically synthesized GNPs using Aspergillus foetidus and characterization of biosynthesized GNPs using various physico-chemical methods. The fairly stable synthesized nanoparticles have size in the range of 10–40 nm. Cytotoxicity study of biosynthesized GNPs on Human lung cancer cell line A549 showed no significant toxicity of GNPs. - Highlights: • A novel biosynthesis process of GNPs using Aspergillus foetidus. • Biosynthesized GNPs are in the range of 10–40 nm as observed from TEM. • This process of synthesis is an optimized biosynthesis process of GNPs. • Biosynthesized GNPs are noncytotoxic against A549 cell line. - Abstract: We study the extracellular biosynthesis of gold nanoparticles (GNPs) using the fungal species Aspergillus foetidus. The formation of GNPs were initially monitored by visual observation and then characterized with the help of various characterization techniques. X-ray diffraction (XRD) results revealed distinctive formation of face centered cubic crystalline GNPs. From field emission scanning electron microscopy (FESEM) the morphology of the nanoparticles were found to be roughly spherical and within the size range of 30–50 nm. The spherical and polydispersed GNPs in the range of 10–40 nm were observed by transmission electron microscopy (TEM) analysis. It was established that alkaline pH, 1 mM gold salt concentration and 75 °C temperature were the respective optimum parameter for biosynthesis of GNPs. Cell cytotoxicity of GNP was compared with that of normal gold salt solution on A549 cell. The A549 cell growth in presence of GNPs was found to be comparatively less toxic than the gold ion.

  15. Mobile Claims Management : Smartphone Apps in Motor Insurance

    OpenAIRE

    Baecker, Oliver; Ackermann, Lukas; Ackermann, Walter; Fleisch, Elgar

    2010-01-01

    As of April 2010, several Swiss motor insurers offer mobile apps that enable customers to submit a loss report. This article discusses the emergence of mobile apps in the insurance industry and the impact of mobile technology on claims management in motor insurance. We also present a demonstrator that goes beyond existing solutions by integrating a mobile app with a commercial claims management enterprise system. The technical aspects are complemented by results from expert interviews on mobi...

  16. Designing, developing, and testing an app for parents being discharged early postnatally

    DEFF Research Database (Denmark)

    Danbjørg, Dorthe Boe; Wagner, Lis; Clemensen, Jane

    2014-01-01

    , and testing of an app as a viable information technology solution. The app was tested with 10 new families. The test results suggest that the new families and the nurses found the app to be viable and the app met the new families' needs for follow-up support. However, the app required refinements and wider...... testing. •We designed, developed, and testet an app for the iPad.•The app was viable, but the app requires refinements and wider testing.•The app met the new families' needs for follow-up support.•There is a potential for ensuring postnatal security with the use of technology....

  17. By the People, for the People: the Crowdsourcing of "STREETBUMP": AN Automatic Pothole Mapping App

    Science.gov (United States)

    Carrera, F.; Guerin, S.; Thorp, J. B.

    2013-05-01

    This paper traces the genesis and development of StreetBump, a smartphone application to map the location of potholes in Boston, Massachusetts. StreetBump belongs to a special category of "subliminal" crowdsourcing mobile applications that turn humans into sensors. Once started, it automatically collects road condition information without any human intervention, using the accelerometers and GPS inside smartphones. The StreetBump app evolved from a hardware device designed and built by WPI's City Lab starting in 2003, which was originally intended to measure and map boat wakes in the city of Venice, Italy (Chiu, 2004). A second version of the custom hardware with onboard GPS and accelerometers was adapted to use in Boston, Massachusetts, to map road damage (potholes) in 2006 (Angelini, 2006). In 2009, Prof. Carrera proposed to the newly created office of New Urban Mechanics in the City of Boston to migrate the concept to Smartphones, based on the Android platform. The first prototype of the mobile app, called StreetBump, was released in 2010 by the authors (Harmon, 2010). In 2011, the app provided the basis for a worldwide Innocentive competition to develop the best postprocessing algorithms to identify the real potholes vs. other phone bumps (Moskowitz, 2011). Starting in 2012, the City of Boston has begun using a subsequent version of the app to operationally manage road repairs based on the data collected by StreetBump. The novelty of this app is not purely technological, but lies also in the top-to-bottom crowdsourcing of all its components. The app was designed to rely on the crowd to confirm the presence of damage though repeat hits (or lack thereof) as more users travel the same roads over time. Moreover, the non-trivial post-processing of the StreetBump data was itself the subject of a crowdsourced competition through an Innocentive challenge for the best algorithm. The release of the StreetBump code as open-source allowed the development of the final

  18. APP physiological and pathophysiological functions:insights from animal models

    Institute of Scientific and Technical Information of China (English)

    Qinxi Guo; Zilai Wang; Hongmei Li; Mary Wiese; Hui Zheng

    2012-01-01

    The amyloid precursor protein (APP) has been under intensive study in recent years,mainly due to its critical role in the pathogenesis of Alzheimer's disease (AD).β-Amyloid (Aβ) peptides generated from APP proteolytic cleavage can aggregate,leading to plaque formation in human AD brains.Point mutations of APP affecting Aβ production are found to be causal for hereditary early onset familial AD.It is very likely that elucidating the physiological properties of APP will greatly facilitate the understanding of its role in AD pathogenesis.A number of APP loss- and gainof-function models have been established in model organisms including Caenorhabditis elegans,Drosophila,zebrafish and mouse.These in vivo models provide us valuable insights into APP physiological functions.In addition,several knock-in mouse models expressing mutant APP at a physiological level are available to allow us to study AD pathogenesis without APP overexpression.This article will review the current physiological and pathophysiological animal models of APP.

  19. Quality of Smartphone Apps Related to Panic Disorder.

    Science.gov (United States)

    Van Singer, Mathias; Chatton, Anne; Khazaal, Yasser

    2015-01-01

    Quality of smartphone apps related to panic: smartphone apps have a growing role in health care. This study assessed the quality of English-language apps for panic disorder (PD) and compared paid and free apps. Keywords related to PD were entered into the Google Play Store search engine. Apps were assessed using the following quality indicators: accountability, interactivity, self-help score (the potential of smartphone apps to help users in daily life), and evidence-based content quality. The Brief DISCERN score and the criteria of the "Health on the Net" label were also used as content quality indicators as well as the number of downloads. Of 247 apps identified, 52 met all inclusion criteria. The content quality and self-help scores of these PD apps were poor. None of the assessed indicators were associated with payment status or number of downloads. Multiple linear regressions showed that the Brief DISCERN score significantly predicted the content quality and self-help scores. Poor content quality and self-help scores of PD smartphone apps highlight the gap between their technological potential and the overall quality of available products.

  20. Security Concerns in Android mHealth Apps

    OpenAIRE

    He, Dongjing; Naveed,Muhammad; Gunter, Carl A.; Nahrstedt, Klara

    2014-01-01

    Mobile Health (mHealth) applications lie outside of regulatory protection such as HIPAA, which requires a baseline of privacy and security protections appropriate to sensitive medical data. However, mHealth apps, particularly those in the app stores for iOS and Android, are increasingly handling sensitive data for both professionals and patients. This paper presents a series of three studies of the mHealth apps in Google Play that show that mHealth apps make widespread use of unsecured Intern...

  1. Apps: a new medium for non-fiction innovation

    Directory of Open Access Journals (Sweden)

    Catherine Allen

    2015-07-01

    Full Text Available Apps are now a dominant content medium: in the US people spend more time on apps than they do watching TV. Non-fiction content is being avidly consumed on mobile devices, but in a completely different way to the book model. This article explores three strands of potential that the app medium holds for non-fiction content, putting forward the case that apps have the power to further weave non-fiction into the fabric of society and life.

  2. Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links.

    Science.gov (United States)

    Sokol, D K; Maloney, B; Long, J M; Ray, B; Lahiri, D K

    2011-04-12

    The present review highlights an association between autism, Alzheimer disease (AD), and fragile X syndrome (FXS). We propose a conceptual framework involving the amyloid-β peptide (Aβ), Aβ precursor protein (APP), and fragile X mental retardation protein (FMRP) based on experimental evidence. The anabolic (growth-promoting) effect of the secreted α form of the amyloid-β precursor protein (sAPPα) may contribute to the state of brain overgrowth implicated in autism and FXS. Our previous report demonstrated that higher plasma sAPPα levels associate with more severe symptoms of autism, including aggression. This molecular effect could contribute to intellectual disability due to repression of cell-cell adhesion, promotion of dense, long, thin dendritic spines, and the potential for disorganized brain structure as a result of disrupted neurogenesis and migration. At the molecular level, APP and FMRP are linked via the metabotropic glutamate receptor 5 (mGluR5). Specifically, mGluR5 activation releases FMRP repression of APP mRNA translation and stimulates sAPP secretion. The relatively lower sAPPα level in AD may contribute to AD symptoms that significantly contrast with those of FXS and autism. Low sAPPα and production of insoluble Aβ would favor a degenerative process, with the brain atrophy seen in AD. Treatment with mGluR antagonists may help repress APP mRNA translation and reduce secretion of sAPP in FXS and perhaps autism.

  3. ‘Gamification’ for Health Behaviour Change in Smartphone Apps

    Directory of Open Access Journals (Sweden)

    Elizabeth Ann Edwards

    2015-09-01

    Full Text Available Background: Gamification techniques are showing promise in promoting healthy behaviours and delivering health promotion advice, however, their use in Mobile-Health is relatively new. Gamification involves using ‘gaming’ elements such as badges, leader boards, health-related challenges, rewards, ability to ‘level up’ and use of avatars to motivate and engage people to change health behavior. Gamification techniques may also overlap with validated health behaviour change techniques (BCTs, however, few apps appear to apply the techniques systematically or to define the BCTs they include. Aim: We aimed a to assess the number apps that incorporate gamification to modify health behaviors, b to examine the BCT repertoire and combinations used in these apps c to consider associations with user satisfaction. Methods: English-language health apps that contain gamification techniques were identified through a systematic search of the official Apple and Google Play store and the NHS health apps library. Top rated free and paid Medical, Health & Wellness, Health & Fitness apps as defined by Apple and Google Play stores were searched. Apps were coded for BCTs according to the Michie et al. taxonomy. The taxonomy comprises 16 categories and 93 individual BCTs. BCT coding was conducted by two trained researchers (EE, JL who scored independently and then cross-checked for discrepancies. BCT numbers, user ratings and app pricing were compared. We explored the association between number of BCTs per app, user and NHS libraries’ ratings and price. We also investigated, which of the 16 BCT categories and the individual 93 BCTs and their combinations were most commonly used. Results: 1,680 Medical, Health & Wellness or Health & Fitness Apps were reviewed and seventy containing gamification techniques were identified. The mean number of BCTs used was 12.5 (range 1-24. There was no correlation between number of BCTs, customer ratings, NHS library app rating or

  4. 3rd MeTrApp Conference

    CERN Document Server

    Lovasz, Erwin-Christian; Hüsing, Mathias

    2015-01-01

    This volume deals with topics such as mechanism and machine design, biomechanics and medical engineering, gears, mechanical transmissions, mechatronics, computational and experimental methods, dynamics of mechanisms and machines, micromechanisms and microactuators, and history of mechanisms and transmissions. Following MeTrApp 2011 and 2013, held under the auspices of the IFToMM, these proceedings of the 3rd Conference on Mechanisms, Transmissions and Applications offer a platform for original research presentations for researchers, scientists, industry experts and students in the fields of mechanisms and transmissions with special emphasis on industrial applications in order to stimulate the exchange of new and innovative ideas.

  5. Teaching Case Design of App Development%App开发教学案例设计

    Institute of Scientific and Technical Information of China (English)

    钟元生; 曹权

    2015-01-01

    为帮助高校更好开设App实践课程,给出一个综合教学案例——"豹考通"App开发的全过程.该教学案例包括App开发流程、服务器端、Android客户端、IOS客户端和数据库端的设计等,不仅适合大学生在项目实验中体会较大规模的App开发全过程,也适合于小组分工协作开发App软件的参照模板.%To help universities better open app practical courses.It gives a comprehensive teaching case-"BaoKaoTong" app whole process of development.The case not only for college students experience a large-scale development of the whole process of app experiment,but also a reference template for group division of labor app software development.

  6. App Factory: A Flexible Approach to Rehabilitation Engineering in an Era of Rapid Technology Advancement.

    Science.gov (United States)

    Jones, Michael; Mueller, James; Morris, John

    2016-08-15

    This article describes a flexible and effective approach to research and development in an era of rapid technological advancement. The approach relies on secondary dispersal of grant funds to commercial developers through a competitive selection process. This "App Factory" model balances the practical reliance on multi-year funding needed to sustain a rehabilitation engineering research center (RERC), with the need for agility and adaptability of development efforts undertaken in a rapidly-changing technology environment. This approach also allows us to take advantage of technical expertise needed to accomplish a particular development task, and provides incentives to deliver successful products in a cost-effective manner. In this article, we describe the App Factory structure, process and results achieved to date; and we discuss the lessons learned and the potential relevance of this approach for other grant-funded research and development efforts. Data presented on the direct costs and number of downloads of the 16 app development projects funded in the App Factory's first 3 years show that it can be an effective means for supporting focused, short-term assistive technology development projects.

  7. Leakiness and Creepiness in App Space: User Perceptions of Privacy and Mobile App Use

    DEFF Research Database (Denmark)

    Shklovski, Irina; Mainwaring, Scott; Skúladóttir, Halla Hrund

    2014-01-01

    Mobile devices are playing an increasingly intimate role in everyday life. However, users can be surprised when in- formed of the data collection and distribution activities of apps they install. We report on two studies of smartphone users in western European countries, in which users were confr...

  8. The App Map: A Tool for Systematic Evaluation of Apps for Early Literacy Learning

    Science.gov (United States)

    Israelson, Madeleine Heins

    2015-01-01

    As portable devices become increasingly available in elementary classrooms teachers are expected to use these new technologies to engage students in both traditional print-based literacy learning and digital literacies practices, such as multimodal composing. Teachers face the daunting task of integrating apps into their current research-based…

  9. The regulation of ascorbate biosynthesis.

    Science.gov (United States)

    Bulley, Sean; Laing, William

    2016-10-01

    We review the regulation of ascorbate (vitamin C) biosynthesis, focusing on the l-galactose pathway. We discuss the regulation of ascorbate biosynthesis at the level of gene transcription (both repression and enhancement) and translation (feedback inhibition of translation by ascorbate concentration) and discuss the eight proteins that have been demonstrated to date to affect ascorbate concentration in plant tissues. GDP-galactose phosphorylase (GGP) and GDP-mannose epimerase are critical steps that regulate ascorbate biosynthesis. These and other biosynthetic genes are controlled at the transcriptional level, while GGP is also controlled at the translational level. Ascorbate feedback on enzyme activity has not been observed unequivocally.

  10. Construction of Recombinant Plasmid Harboring APP717 Mutation and Preliminary Study of APP Proteolysis

    Institute of Scientific and Technical Information of China (English)

    LI Xiaoqing; XUE Zheng; ZHANG Suming

    2007-01-01

    In order to investigate the pathogenesis of Alzheimer disease (AD) and study the enzy-matic progress of amyloid precursor protein (APP), the fluorescent eukaryotic expression plasmid of C99 was constructed containing APP717 mutation. The fragment encoding the last 99-aa of APP(which was named C99 containing APP717 mutation), together with the fragment encoding yellow fluorescence protein (which was named YFP) were amplified by PCR. The two fragments (YFP andC99) were inserted into the vector pcDNA3.0. The recombinant plasmid pcDNA3.0-YFP-C99 was accomplished and its authenticity was confirmed by enzyme digestion and sequencing. Then SH-SY5Y cells were transiently transfected with the recombinant plasmid pcDNA3.0-YFP-C99. The expression of the fusion gene was detected by laser confocalmicroscopy. Amyloid-β (Aβ) was de- tected by both microscopy and immunochemistry. The authenticity of the construct was confirmed by the endonuclease digestion and DNA sequencing. The YFP fluorescence could be seen and proved the expression of fusion gene. Aβ labeled by YFP was detected by confocalmicroscopy and confirmed by immunocytochemistry. It was found that Aβ accumulated and deposited in the intracytoplasm, mem-brane and outside of the cell. Furthermore, Aβ accumulated mainly within the cell ahead of the depo-sition in the cell space and the cell shape was rough. It was suggested that Aβ could be generatedwithin the cells. Aβ accumulated in the cell at the early stage before the deposition outside of the cells.Intracellular Aβ accumulation induced the secondary damage to the cells and caused the cell shape rough. Taken together, the recombinant plasmid, pcDNA3.0-YFP-C99 could be a useful tool to fur-ther study the cleavage mechanism of APP and to explore the pathogenesis of AD.

  11. The Utilization of the iOS Platform to Create LearnENT: An Interactive Educational App in Otolaryngology—Head and Neck Surgery

    Directory of Open Access Journals (Sweden)

    S. Kohlert

    2012-01-01

    Full Text Available LearnENT, an educational app for iOS, was developed to promote a standardized experience otolaryngology in head and neck surgery (OTOHNS for University of Ottawa medical students. Its development was grounded in pedagogical theory including Laurillard’s design process, Honey and Mumford’s learning styles, and Nielsen’s theory of usability. This paper examines LearnENT's design and development processes as well as the role of mobile apps in medical education. Features of the LearnENT app as they apply to Constructivist learning are also highlighted.

  12. App-assisted external ventricular drain insertion.

    Science.gov (United States)

    Eftekhar, Behzad

    2016-09-01

    The freehand technique for insertion of an external ventricular drain (EVD) is based on fixed anatomical landmarks and does not take individual variations into consideration. A patient-tailored approach based on augmented-reality techniques using devices such as smartphones can address this shortcoming. The Sina neurosurgical assist (Sina) is an Android mobile device application (app) that was designed and developed to be used as a simple intraoperative neurosurgical planning aid. It overlaps the patient's images from previously performed CT or MRI studies on the image seen through the device camera. The device is held by an assistant who aligns the images and provides information about the relative position of the target and EVD to the surgeon who is performing EVD insertion. This app can be used to provide guidance and continuous monitoring during EVD placement. The author describes the technique of Sina-assisted EVD insertion into the frontal horn of the lateral ventricle and reports on its clinical application in 5 cases as well as the results of ex vivo studies of ease of use and precision. The technique has potential for further development and use with other augmented-reality devices.

  13. Diverse inhibitors of aflatoxin biosynthesis.

    Science.gov (United States)

    Holmes, Robert A; Boston, Rebecca S; Payne, Gary A

    2008-03-01

    Pre-harvest and post-harvest contamination of maize, peanuts, cotton, and tree nuts by members of the genus Aspergillus and subsequent contamination with the mycotoxin aflatoxin pose a widespread food safety problem for which effective and inexpensive control strategies are lacking. Since the discovery of aflatoxin as a potently carcinogenic food contaminant, extensive research has been focused on identifying compounds that inhibit its biosynthesis. Numerous diverse compounds and extracts containing activity inhibitory to aflatoxin biosynthesis have been reported. Only recently, however, have tools been available to investigate the molecular mechanisms by which these inhibitors affect aflatoxin biosynthesis. Many inhibitors are plant-derived and a few may be amenable to pathway engineering for tissue-specific expression in susceptible host plants as a defense against aflatoxin contamination. Other compounds show promise as protectants during crop storage. Finally, inhibitors with different modes of action could be used in comparative transcriptional and metabolomic profiling experiments to identify regulatory networks controlling aflatoxin biosynthesis.

  14. The fitness of apps: a theory-based examination of mobile fitness app usage over 5 months

    Science.gov (United States)

    Kim, Jinsook

    2017-01-01

    Background There are thousands of fitness-related smartphone applications (“apps”) available for free and purchase, but there is uncertainty if these apps help individuals achieve and maintain personal fitness. Technology usage attrition is also a concern among research studies on health technologies. Methods Usage of three fitness apps was examined over 5 months to assess adherence and effectiveness. Initially, 64 participants downloaded three free apps available on Android and iOS and 47 remained in the study until posttest. With a one group pre-posttest design and checkpoints at months 1, 3, and 5, exercise and exercise with fitness apps were examined in the framework of the Theory of Planned Behavior (TPB) using a validated survey. Apps were selected based on their function from the Functional Triad. Perceived fitness was also measured. T-tests, sign tests, Fisher’s exact tests, and linear and logistic regression were used to compare pre to posttests and users to non-users of the apps. Results Forty-seven participants completed both pre and posttests. Individual item scores indicated no significant change pre to posttest except for decreases observed in usefulness of using apps for exercise (attitude) (−0.78, P<0.01), peer influence on exercise (subjective norm) (−0.51, P<0.05), peer influence on exercise with apps (subjective norm) (−1.02, P<0.01), perceived difficulties in exercising with apps (perceived behavioral control) (−1.29, P<0.001), and the expected frequency of exercise with apps over the next 2 weeks (behavioral intention) (P<0.0001 in a sign test). Subscale total scores indicated significant decreases in subjective norm regarding exercise (−0.72, P<0.05), subjective norm regarding exercise with apps (−1.72, P<0.01), and perceived behavioral control over exercising with apps (−2.56, P<0.01) between pre and posttest. When comparing app users (n=32) to non-users (n=15), there was only a significant difference in subscale total

  15. (IN-PRIVACY IN MOBILE APPS. CUSTOMER OPPORTUNITIES

    Directory of Open Access Journals (Sweden)

    Yu.S. Chemerkina

    2016-01-01

    Full Text Available Subject of Study. The paper presents the results of an investigation of cross-platform mobile applications. This paper focuses on a cross-platform app data investigation in purpose of creating a database that helps to make decisions from data privacy viewpoint. These decisions refer to knowledge about mobile apps that are available to the public, especially on how consumer data is protected while it is stored locally or transferred via network as well as what type of data may leak. Methods. This paper proposes a forensics methodology as a cornerstone of an app data investigation process. The object of research is an application data protection under different security control types among modern mobile OS. The subject of research is a modification of forensics approach and behavioral analysis to examine application data privacy in order to find data that are not properly handled by applications which lead to data leakages, defining protection control type without forensics limits. In addition, this paper relies on using the simplest tools, proposing a limit to examine locally stored data and transmitted over the network to cover all data, excluding memory and code analysis unless it is valuable (behavioral analysis. The research methods of the tasks set in the paper include digital forensics approach methods depending on data conception (at-rest, in-use/memory, in-transit with behavioral analysis of application, and static and dynamic application code analysis. Main Results. The research was carried out for the scope of that thesis, and the following scientific results were obtained. First, the methods used to investigate the privacy of application data allow considering application features and protection code design and flaws in the context of incomplete user awareness about the privacy state due to external activity of the developer. Second, the knowledge set about facts of application data protection that allows making a knowledge database to

  16. App Inventor 2开发手机益智游戏

    Institute of Scientific and Technical Information of China (English)

    黄皓

    2014-01-01

    为了方便非计算机专业的人士也能快速地进行Android移动应用程序开发,谷歌公司研发了App Inventor,这是一种拼图式的应用开发工具。介绍App Inventor 2的在线、离线使用方式,组件设计器和块编辑器的用法,并通过一个100以内四则运算的益智游戏实例对开发过程进行了说明。%In order to facilitate non-computer professional who can quickly make Android mobile application development,Google has developed the App Inventor,which is a puzzle-like application development tools base on Open Blocks. This article introduces online,oflfine use of App Inventor 2,the use of the component designer and the block editor,then describs the development process of an arithmetic game for instances.

  17. Titan: An Enabling Framework for Activity-Aware "Pervasive Apps" in Opportunistic Personal Area Networks

    Directory of Open Access Journals (Sweden)

    Roggen Daniel

    2011-01-01

    Full Text Available Upcoming ambient intelligence environments will boast ever larger number of sensor nodes readily available on body, in objects, and in the user's surroundings. We envision "Pervasive Apps", user-centric activity-aware pervasive computing applications. They use available sensors for activity recognition. They are downloadable from application repositories, much like current Apps for mobile phones. A key challenge is to provide Pervasive Apps in open-ended environments where resource availability cannot be predicted. We therefore introduce Titan, a service-oriented framework supporting design, development, deployment, and execution of activity-aware Pervasive Apps. With Titan, mobile devices inquire surrounding nodes about available services. Internet-based application repositories compose applications based on available services as a service graph. The mobile device maps the service graph to Titan Nodes. The execution of the service graph is distributed and can be remapped at run time upon changing resource availability. The framework is geared to streaming data processing and machine learning, which is key for activity recognition. We demonstrate Titan in a pervasive gaming application involving smart dice and a sensorized wristband. We comparatively present the implementation cost and performance and discuss how novel machine learning methodologies may enhance the flexibility of the mapping of service graphs to opportunistically available nodes.

  18. A study on interaction App platform between expert knowledge and community applied on disaster education

    Science.gov (United States)

    Ruljigaljig, T.; Huang, M. L.

    2015-12-01

    This study development interface for Mobile Application (App) use cloud technology, Web 2.0 and online community of technology to build the Environmental-Geological Disaster Network(EDN). The interaction App platform between expert knowledge and community is developed as a teaching tool, which bases on the open data released by Central Geological Survey. The APP can through Augmented Reality technology to potential hazards position through the camera lens, the real show in real-world environment. The interaction with experts in the community to improve the general public awareness of disaster. Training people to record the occurrence of geological disasters precursor, thereby awakened their to natural disaster consciousness and attention.General users obtain real-time information during travel, mountaineering and teaching process. Using App platform to upload and represent the environmental geological disaster data collected by themselves. It is expected that by public joint the open platform can accumulate environmental geological disaster data effectively, quickly, extensively and correctly. The most important thing of this study is rooting the concept of disaster prevention, reduction, and avoidance through public participation.

  19. BIDS apps: Improving ease of use, accessibility, and reproducibility of neuroimaging data analysis methods

    Science.gov (United States)

    Auer, Tibor; Churchill, Nathan W.; Flandin, Guillaume; Guntupalli, J. Swaroop; Raffelt, David; Quirion, Pierre-Olivier; Smith, Robert E.; Strother, Stephen C.; Varoquaux, Gaël

    2017-01-01

    The rate of progress in human neurosciences is limited by the inability to easily apply a wide range of analysis methods to the plethora of different datasets acquired in labs around the world. In this work, we introduce a framework for creating, testing, versioning and archiving portable applications for analyzing neuroimaging data organized and described in compliance with the Brain Imaging Data Structure (BIDS). The portability of these applications (BIDS Apps) is achieved by using container technologies that encapsulate all binary and other dependencies in one convenient package. BIDS Apps run on all three major operating systems with no need for complex setup and configuration and thanks to the comprehensiveness of the BIDS standard they require little manual user input. Previous containerized data processing solutions were limited to single user environments and not compatible with most multi-tenant High Performance Computing systems. BIDS Apps overcome this limitation by taking advantage of the Singularity container technology. As a proof of concept, this work is accompanied by 22 ready to use BIDS Apps, packaging a diverse set of commonly used neuroimaging algorithms. PMID:28278228

  20. 76 FR 49485 - Announcement of Requirements and Registration for “Lifeline Facebook App Challenge”

    Science.gov (United States)

    2011-08-10

    ... HUMAN SERVICES Announcement of Requirements and Registration for ``Lifeline Facebook App Challenge...: The ``Lifeline Facebook App Challenge'' is a challenge aimed at multidisciplinary teams of technology... Facebook as a platform for connecting individuals together through an application (app) that will...

  1. Transcellular biosynthesis of eicosanoid lipid mediators.

    Science.gov (United States)

    Capra, Valérie; Rovati, G Enrico; Mangano, Paolo; Buccellati, Carola; Murphy, Robert C; Sala, Angelo

    2015-04-01

    The synthesis of oxygenated eicosanoids is the result of the coordinated action of several enzymatic activities, from phospholipase A2 that releases the polyunsaturated fatty acids from membrane phospholipids, to primary oxidative enzymes, such as cyclooxygenases and lipoxygenases, to isomerases, synthases and hydrolases that carry out the final synthesis of the biologically active metabolites. Cells possessing the entire enzymatic machinery have been studied as sources of bioactive eicosanoids, but early on evidence proved that biosynthetic intermediates, albeit unstable, could move from one cell type to another. The biosynthesis of bioactive compounds could therefore be the result of a coordinated effort by multiple cell types that has been named transcellular biosynthesis of the eicosanoids. In several cases cells not capable of carrying out the complete biosynthetic process, due to the lack of key enzymes, have been shown to efficiently contribute to the final production of prostaglandins, leukotrienes and lipoxins. We will review in vitro studies, complex functional models, and in vivo evidences of the transcellular biosynthesis of eicosanoids and the biological relevance of the metabolites resulting from this unique biosynthetic pathway. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA: analysis and biological relevance".

  2. iOS and OS X Apps for Exploring Earthquake Activity

    Science.gov (United States)

    Ammon, C. J.

    2015-12-01

    The U.S. Geological Survey and many other agencies rapidly provide information following earthquakes. This timely information garners great public interest and provides a rich opportunity to engage students in discussion and analysis of earthquakes and tectonics. In this presentation I will describe a suite of iOS and Mac OS X apps that I use for teaching and that Penn State employs in outreach efforts in a small museum run by the College of Earth and Mineral Sciences. The iOS apps include a simple, global overview of earthquake activity, epicentral, designed for a quick review or event lookup. A more full-featured iPad app, epicentral-plus, includes a simple global overview along with views that allow a more detailed exploration of geographic regions of interest. In addition, epicentral-plus allows the user to monitor ground motions using seismic channel lists compatible with the IRIS web services. Some limited seismogram processing features are included to allow focus on appropriate signal bandwidths. A companion web site, which includes background material on earthquakes, and a blog that includes sample images and channel lists appropriate for monitoring earthquakes in regions of recent earthquake activity can be accessed through the a third panel in the app. I use epicentral-plus at the beginning of each earthquake seismology class to review recent earthquake activity and to stimulate students to formulate and to ask questions that lead to discussions of earthquake and tectonic processes. Less interactive OS X versions of the apps are used to display a global map of earthquake activity and seismograms in near real time in a small museum on the ground floor of the building hosting Penn State's Geoscience Department.

  3. An Analysis of WhatsApp Forensics in Android Smartphones

    OpenAIRE

    Shubham Sahu

    2014-01-01

    — WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on Android phones has turned to be goldmine for mobile and computer forensic investigators. This paper focuses on conducting forensic data analysis by extracting useful information from WhatsApp and from similar applications installed on Android platform.

  4. Mobile Distance Learning with Smartphones and Apps in Higher Education

    Science.gov (United States)

    Vázquez-Cano, Esteban

    2014-01-01

    In this paper, the results of researcher' ongoing activities regarding the use of smartphones and a specific subject-app used at the Spanish National University of Distance Education (UNED) have been reported. The purpose of this trial is to assess the app's didactic use and potential to enhance student learning in university subjects in…

  5. Citrix XenApp 7.5 desktop virtualization solutions

    CERN Document Server

    Paul, Andy

    2014-01-01

    If you are a Citrix® engineer, a virtualization consultant, or an IT project manager with prior experience of using Citrix XenApp® and related technologies for desktop virtualization and want to further explore the power of XenApp® for flawless desktop virtualization, then this book is for you.

  6. A Comprehensive Evaluation Rubric for Assessing Instructional Apps

    Science.gov (United States)

    Lee, Cheng-Yuan; Cherner, Todd Sloan

    2015-01-01

    There is a pressing need for an evaluation rubric that examines all aspects of educational apps designed for instructional purposes. In past decades, many rubrics have been developed for evaluating educational computer-based programs; however, rubrics designed for evaluating the instructional implications of educational apps are scarce. When an…

  7. WhatsApp in Clinical Practice: A Literature Review.

    Science.gov (United States)

    Mars, Maurice; Scott, Richard E

    2016-01-01

    Several spontaneous telemedicine services using WhatsApp Messenger have started in South Africa raising issues of confidentiality, data security and storage, record keeping and reporting. This study reviewed the literature on WhatsApp in clinical practice, to determine how it is used, and users' satisfaction.

  8. Availability and quality of mobile health app privacy policies.

    Science.gov (United States)

    Sunyaev, Ali; Dehling, Tobias; Taylor, Patrick L; Mandl, Kenneth D

    2015-04-01

    Mobile health (mHealth) customers shopping for applications (apps) should be aware of app privacy practices so they can make informed decisions about purchase and use. We sought to assess the availability, scope, and transparency of mHealth app privacy policies on iOS and Android. Over 35,000 mHealth apps are available for iOS and Android. Of the 600 most commonly used apps, only 183 (30.5%) had privacy policies. Average policy length was 1755 (SD 1301) words with a reading grade level of 16 (SD 2.9). Two thirds (66.1%) of privacy policies did not specifically address the app itself. Our findings show that currently mHealth developers often fail to provide app privacy policies. The privacy policies that are available do not make information privacy practices transparent to users, require college-level literacy, and are often not focused on the app itself. Further research is warranted to address why privacy policies are often absent, opaque, or irrelevant, and to find a remedy.

  9. Microlearning mApp raises health competence: hybrid service design

    NARCIS (Netherlands)

    Simons, L.P.A.; Foerster, F.; Bruck, P.A.; Motiwalla, L.; Jonker, C.M.

    2015-01-01

    Work place health support interventions can help support our aging work force, with mApps offering cost-effectiveness opportunities. Previous research shows that health support apps should offer users enough newness and relevance each time they are used. Otherwise the ‘eHealth law of attrition’ appl

  10. Smartphone Technology and Apps: Rapidly Changing Health Promotion

    Science.gov (United States)

    Kratzke, Cynthia; Cox, Carolyn

    2012-01-01

    Despite the increased availability of smartphones and health applications (apps), little is known about smartphone technology and apps for implementation in health promotion practice. Smartphones are mobile devices with capabilities for e-mail, text messaging, video viewing, and wireless Internet access. It is essential for health promotion…

  11. Examining Preservice Teachers' Criteria for Evaluating Educational Mobile Apps

    Science.gov (United States)

    Baran, Evrim; Uygun, Erdem; Altan, Tugba

    2017-01-01

    Recent interest in integrating mobile apps into teaching will continue growing. There remains, however, a pressing need to develop methods and resources to support and educate preservice teachers about the use of these technologies. This case study aimed to examine preservice teachers' criteria for evaluating educational mobile apps. Nineteen…

  12. Validation of a Tool Evaluating Educational Apps for Smart Education

    Science.gov (United States)

    Lee, Jeong-Sook; Kim, Sung-Wan

    2015-01-01

    The purpose of this study is to develop and validate an evaluation tool of educational apps for smart education. Based on literature reviews, a potential model for evaluating educational apps was suggested. An evaluation tool consisting of 57 survey items was delivered to 156 students in middle and high schools. An exploratory factor analysis was…

  13. Free Play or Tight Spaces? Mapping Participatory Literacies in Apps

    Science.gov (United States)

    Rowsell, Jennifer; Wohlwend, Karen

    2016-01-01

    Building on existing research applying app maps (Israelson, 2015), the authors take an ideological orientation to broaden app evaluations and consider participatory literacies, social and communicational practices relevant to children's everyday digitally mediated lives. Drawing from their North American elementary classroom studies on children's…

  14. "Apps"--An Innovative Way to Share Extension Knowledge

    Science.gov (United States)

    Dvorak, Joseph S.; Franke-Dvorak, Tanya C.; Price, Randy R.

    2012-01-01

    Extension professionals across the country are continuously seeking innovative ways to reach clientele and to disseminate timely, educational information. A new avenue to reach clientele includes the use of smartphone "apps." The "Machinery Sizing" app, which was developed to ease the estimation of tractor horsepower to…

  15. Using a Mobile Gaming App to Enhance Accounting Education

    Science.gov (United States)

    Seow, Poh-Sun; Wong, Suay-Peng

    2016-01-01

    The authors describe the first mobile gaming app for learning accounting, Accounting Challenge (ACE). On September 30, 2016, ACE had been downloaded 23,230 times, spanning 90 countries, and had won three international teaching awards. The app was motivated by the aim to empower students to learn accounting in a fun way, outside of the classroom.…

  16. Biosynthesis of Nitrogenase FeMoco

    OpenAIRE

    Hu, Yilin; Ribbe, Markus W.

    2011-01-01

    Biosynthesis of nitrogenase FeMoco is a highly complex process that requires, minimally, the participation of nifS, nifU, nifB, nifE, nifN, nifV, nifH, nifD and nifK gene products. Previous genetic analyses have identified the essential factors for the assembly of FeMoco; however, the exact functions of these factors and the precise sequence of events during the assembly process had remained unclear until recently, when a number of the biosynthetic intermediates of FeMoco were identified and ...

  17. GeoMapApp: A Cross-Platform app for Geophysical Data Exploration and Visualisation

    Science.gov (United States)

    Goodwillie, A. M.

    2015-12-01

    Apps that provide convenient, integrated access to a range of geophysical data have wide applicability in both research and teaching. GeoMapApp (http://www.geomapapp.org), a free, map-based data discovery and visualisation tool developed with NSF funding at Lamont-Doherty Earth Observatory provides casual and specialist users alike with intuitive access to hundreds of built-in geoscience data sets covering geophysics, geochemistry, geology, oceanography, and cryospherics. Users can also import their own data tables, spreadsheets, shapefiles, grids, and images. Simple manipulation and analysis tools combined with layering capabilities and engaging visualisations provide a powerful app with which to explore and interrogate geoscience data in its proper geospatial context thus helping users to more easily gain deeper insight and understanding from real-world data. The backbone of GeoMapApp is a regularly-updated multi-resolution elevation base map covering the oceans and continents and includes measurements ranging from Space Shuttle terrestrial data to ultra-high-resolution surveys of coral reefs and seafloor hydrothermal vent fields. Examples of built-in geophysical data sets include interactive earthquake locations and focal mechanism (CMT) solutions; underway cruise track profiles; plate tectonic velocities, seafloor crustal age and heat flow; multi-channel seismic reflection profiles; gravity, magnetic, and geoid anomalies; sidescan; subduction zone interface depths; and, EarthScope station locations. Dynamic links point to data sources and additional information. There are dedicated menus for GeoPRISMS, MARGINS, and Ridge2000 data sets. A versatile profiling tool provides instant access to data cross-sections, and contouring and 3-D views are also offered. Tabular data - both imported and built-in - can be displayed in a variety of ways and users can quickly select data points directly from the map. Layer opacity and on/off toggles allow easy data set

  18. Exploring the materiality of literary apps for children

    DEFF Research Database (Denmark)

    Henkel, Ayoe Qvist

    2016-01-01

    With its possibilities of combining text, music, sound effects, stills, animation movies, verbal language, and, not least, interactivity, children’s literature is increasingly being realized in the app-format. This digital and medial literary development calls for new analytical approaches...... of interaction, this article suggests how a materiality approach can shed light on the formation of meaning in literary apps for children. The analysis is founded on three aspects of materiality of literary apps: its manifestation as text, its embedment in a medium, and its manner of being and interacting...... an understanding for literary apps for children and cross-media reading. Keywords Literary apps for children, materiality, digital literature, N. Katherine Hayles, interface...

  19. Security Concerns in Android mHealth Apps.

    Science.gov (United States)

    He, Dongjing; Naveed, Muhammad; Gunter, Carl A; Nahrstedt, Klara

    2014-01-01

    Mobile Health (mHealth) applications lie outside of regulatory protection such as HIPAA, which requires a baseline of privacy and security protections appropriate to sensitive medical data. However, mHealth apps, particularly those in the app stores for iOS and Android, are increasingly handling sensitive data for both professionals and patients. This paper presents a series of three studies of the mHealth apps in Google Play that show that mHealth apps make widespread use of unsecured Internet communications and third party servers. Both of these practices would be considered problematic under HIPAA, suggesting that increased use of mHealth apps could lead to less secure treatment of health data unless mHealth vendors make improvements in the way they communicate and store data.

  20. Building Android Apps with HTML, CSS, and JavaScript

    CERN Document Server

    Stark, Jonathan

    2010-01-01

    If you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. This hands-on book shows you how to use these open source web standards to design and build apps that can be adapted for any Android device -- without having to use Java. You'll learn how to create an Android-friendly web app on the platform of your choice, and then convert it to a native Android app with the free PhoneGap framework. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and a broader reach. Learn the

  1. PENENTUAN PRODUK OLAHAN APEL UNGGULAN MENGGUNAKAN TEKNIK FUZZY NON NUMERIK AN ANALISIS STRUKTUR SERTA POLA PEMBINAAN KELEMBAGAAN [Determination Prosprctive Appe processing product Using Non-Numeric Fuzzy Method, Analyze Institutional Structure and Develompent Model

    Directory of Open Access Journals (Sweden)

    Imam Santoso 1

    2001-08-01

    Full Text Available Apple and its processing product is one of prospective commodities in Malang, East Java. The article discussed application of fuzzy non-numerik decision making to select prospective apple processing product, analyse institutional structure using ISM method and determine development model using AHP method. The research result showed apple dodol selected as the most prospective product with high category elements of entrepreneur, corporation, and high ediucation are as independent elements; and partnership (46% selected as model of institutional estabilishment.

  2. A Kind of Multifunctional Safety Business Card APP%一种多功能安全名片APP

    Institute of Scientific and Technical Information of China (English)

    郑荣茂; 杨金艳

    2016-01-01

    名片在商务交往或社交活动中经常使用。传统纸质名片存在信息容量低、信息更新后名片即作废、多为一次性用品易造成资源浪费等问题;电子名片存在操作不便、使用过程存在安全隐患等问题。文中针对智能手机强大的运算和灵活的数字通讯功能设计一种多功能安全名片APP,开发Android系统下的APP应用程序。安全名片APP具有信息内容丰富,支持多媒体功能;有多种信息交换功能,信息传递及使用过程中具有安全、便捷、高效等优点有很好的应用和推广价值。%Business cards are frequently used in business communication or social activities. The traditional paper-based business card has many problems, such as the information capacity is low, the business card will be deleted after the renewal of information, the disposable products is easy to cause waste of resources and so on. The electronic business cards have the problems such as the inconvenient operation, the hidden danger in use procedure and so on. This paper designs a kind of multifunctional security card APP, which is based on the functions of powerful computing and flexible digital communication of the intelligent mobile phone, to develop the APP application under the Android system. The security card APP has rich information content, which supports the multimedia function, and has the exchange function of many kinds of information. It is safe, convenient, and high efficiency in the use process and has very good application and promotion value.

  3. Using Mobile App Development Tools to Build a GIS Application

    Science.gov (United States)

    Mital, A.; Catchen, M.; Mital, K.

    2014-12-01

    Our group designed and built working web, android, and IOS applications using different mapping libraries as bases on which to overlay fire data from NASA. The group originally planned to make app versions for Google Maps, Leaflet, and OpenLayers. However, because the Leaflet library did not properly load on Android, the group focused efforts on the other two mapping libraries. For Google Maps, the group first designed a UI for the web app and made a working version of the app. After updating the source of fire data to one which also provided historical fire data, the design had to be modified to include the extra data. After completing a working version of the web app, the group used webview in android, a built in resource which allowed porting the web app to android without rewriting the code for android. Upon completing this, the group found Apple IOS devices had a similar capability, and so decided to add an IOS app to the project using a function similar to webview. Alongside this effort, the group began implementing an OpenLayers fire map using a simpler UI. This web app was completed fairly quickly relative to Google Maps; however, it did not include functionality such as satellite imagery or searchable locations. The group finished the project with a working android version of the Google Maps based app supporting API levels 14-19 and an OpenLayers based app supporting API levels 8-19, as well as a Google Maps based IOS app supporting both old and new screen formats. This project was implemented by high school and college students under an SGT Inc. STEM internship program

  4. Earthquake Early Warning Beta Users: Java, Modeling, and Mobile Apps

    Science.gov (United States)

    Strauss, J. A.; Vinci, M.; Steele, W. P.; Allen, R. M.; Hellweg, M.

    2014-12-01

    Earthquake Early Warning (EEW) is a system that can provide a few to tens of seconds warning prior to ground shaking at a user's location. The goal and purpose of such a system is to reduce, or minimize, the damage, costs, and casualties resulting from an earthquake. A demonstration earthquake early warning system (ShakeAlert) is undergoing testing in the United States by the UC Berkeley Seismological Laboratory, Caltech, ETH Zurich, University of Washington, the USGS, and beta users in California and the Pacific Northwest. The beta users receive earthquake information very rapidly in real-time and are providing feedback on their experiences of performance and potential uses within their organization. Beta user interactions allow the ShakeAlert team to discern: which alert delivery options are most effective, what changes would make the UserDisplay more useful in a pre-disaster situation, and most importantly, what actions users plan to take for various scenarios. Actions could include: personal safety approaches, such as drop cover, and hold on; automated processes and procedures, such as opening elevator or fire stations doors; or situational awareness. Users are beginning to determine which policy and technological changes may need to be enacted, and funding requirements to implement their automated controls. The use of models and mobile apps are beginning to augment the basic Java desktop applet. Modeling allows beta users to test their early warning responses against various scenarios without having to wait for a real event. Mobile apps are also changing the possible response landscape, providing other avenues for people to receive information. All of these combine to improve business continuity and resiliency.

  5. Parent and Clinician Preferences for an Asthma App to Promote Adolescent Self-Management: A Formative Study

    Science.gov (United States)

    Roberts, Courtney A; Sage, Adam J; Coyne-Beasley, Tamera; Sleath, Betsy L; Carpenter, Delesha M

    2016-01-01

    Background Most youth asthma apps are not designed with parent and clinician use in mind, and rarely is the app development process informed by parent or clinician input. Objective This study was conducted to generate formative data on the use, attitudes, and preferences for asthma mHealth app features among parents and clinicians, the important stakeholders who support adolescents with asthma and promote adolescent self-management skills. Methods We conducted a mixed-methods study from 2013 to 2014 employing a user-centered design philosophy to acquire feedback from a convenience sample of 20 parents and 6 clinicians. Participants were given an iPod Touch and asked to evaluate 10 features on 2 existing asthma apps. Participant experiences using the apps were collected from questionnaires and a thematic analysis of audio-recorded and transcribed (verbatim) interviews using MAXQDA. Descriptive statistics were calculated to characterize the study sample and app feature feedback. Independent samples t tests were performed to compare parent and clinician ratings of app feature usefulness (ratings: 1=not at all useful to 5=very useful). Results All parents were female (n=20), 45% were black, 20% had an income ≥US $50,000, and 45% had a bachelor’s degree or higher education. The clinician sample included 2 nurses and 4 physicians with a mean practice time of 13 years. Three main themes provided an understanding of how participants perceived their roles and use of asthma app features to support adolescent asthma self-management: monitoring and supervision, education, and communication/information sharing. Parents rated the doctor report feature highest, and clinicians rated the doctor appointment reminder highest of all evaluated app features on usefulness. The peak flow monitoring feature was the lowest ranked feature by both parents and clinicians. Parents reported higher usefulness for the doctor report (t(10)=2.7, Pdesigned to help support youth asthma management

  6. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD.

    Directory of Open Access Journals (Sweden)

    Sarah Lincoln

    Full Text Available Leucine rich repeat transmembrane protein 3 (LRRTM3 is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3 and resides at the linkage peak for late-onset Alzheimer's disease (LOAD risk and plasma amyloid β (Aβ levels. In-vitro knock-down of LRRTM3 was previously shown to decrease secreted Aβ, although the mechanism of this is unclear. In SH-SY5Y cells overexpressing APP and transiently transfected with LRRTM3 alone or with BACE1, we showed that LRRTM3 co-localizes with both APP and BACE1 in early endosomes, where BACE1 processing of APP occurs. Additionally, LRRTM3 co-localizes with APP in primary neuronal cultures from Tg2576 mice transduced with LRRTM3-expressing adeno-associated virus. Moreover, LRRTM3 co-immunoprecipitates with both endogenous APP and overexpressed BACE1, in HEK293T cells transfected with LRRTM3. SH-SY5Y cells with knock-down of LRRTM3 had lower BACE1 and higher CTNNA3 mRNA levels, but no change in APP. Brain mRNA levels of LRRTM3 showed significant correlations with BACE1, CTNNA3 and APP in ∼400 humans, but not in LRRTM3 knock-out mice. Finally, we assessed 69 single nucleotide polymorphisms (SNPs within and flanking LRRTM3 in 1,567 LOADs and 2,082 controls and identified 8 SNPs within a linkage disequilibrium block encompassing 5'UTR-Intron 1 of LRRTM3 that formed multilocus genotypes (MLG with suggestive global association with LOAD risk (p = 0.06, and significant individual MLGs. These 8 SNPs were genotyped in an independent series (1,258 LOADs and 718 controls and had significant global and individual MLG associations in the combined dataset (p = 0.02-0.05. Collectively, these results suggest that protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD.

  7. Mobile app versus Web app: a comparison using 2008-2012 "PubMed for Handhelds" server data.

    Science.gov (United States)

    Fontelo, Paul; Liu, Fang

    2013-01-01

    Recent surveys show that mobile apps are more popular than Web apps. Apple's iTunes Store, now has about 800,000 apps and reported to have about 40 billion downloads. Android apps, although fewer, is available to the most number of smartphones today. About 40,000 apps are medical or health related. We developed a PubMed4Hh mobile app for iPhone/iPad users to search MEDLINE/PubMed with same features as our Web-based search tools, in use since 2002. Five-year (2008-2012) server data for PubMed4Hh and Web app were analyzed. Searches using the mobile app significantly increased compared to the same five-year time period. Month-by-month comparison showed a 3 to 5-fold increase in queries. The six-month total accesses comparison increased 280% from the previous four-year average. A review of 500 randomly selected queries revealed that the majority of queries were clinical questions ((97.8%) and 61% of these queries are searches related to therapy.

  8. Apps and EFL: A Case Study on the Use of Smartphone Apps to Learn English by Four Japanese University Students

    Science.gov (United States)

    Mindog, Emily

    2016-01-01

    This study explores, describes and analyzes the utilization of smartphone apps by four Japanese university students to support learning English as a Foreign Language (EFL). Findings indicate that intermediate language learners use apps to access content and communicate on SNS and are not keen on studying discrete language parts. Participants…

  9. Instant RubyMotion app development

    CERN Document Server

    Laborde, Gant

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. This book is a practical, task-based, step-by-step tutorial that will get you started with using RubyMotion to quickly and efficiently write iOS apps.To make the most of this book, you should understand the basics of programming concepts and have a basic understanding of a language similar to Ruby. If you are an Objective-C programmer, you'll learn the advantages of RubyMotion which can access the benefits of Cocoapods, but takes everything a st

  10. SimApp 1.8.x

    Energy Technology Data Exchange (ETDEWEB)

    2017-02-21

    System for converting DESIRE (Direct Executing Simulation in Real Time) simulation models to executable code models (C# / C++). These converted models are used as the basis for 2 products, one of which is the focus of this review: an engineering design interface for Fissile Solution Systems. ModelConverter.exe (C#) converts DESIRE model inputs to a C++ plug-in subclass. SimApp.exe (C# / C++) has a C++ dll that is a numerical integration engine that the Converted models plug into. The engineering design interface is a C# GUI that calls on the C++ dll to execute a particular converted model. The GUI allows the user to specify the length of a simulation, run the simulation, view data plots and data tables. Stability plots may also be produced and manipulated. The engineering design interface will be released as source code and executable; the model converter source is also intended for release.

  11. Building Android Apps with HTML, CSS, and JavaScript Making Native Apps with Standards-Based Web Tools

    CERN Document Server

    Stark, Jonathan

    2012-01-01

    It's true: if you know HTML, CSS, and JavaScript, you already have the tools you need to develop Android applications. Now updated for HTML5, the second edition of this hands-on guide shows you how to use open source web standards to design and build apps that can be adapted for any Android device. You'll learn how to create an Android-friendly web app on the platform of your choice, and then use Adobe's free PhoneGap framework to convert it to a native Android app. Discover why device-agnostic mobile apps are the wave of the future, and start building apps that offer greater flexibility and

  12. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease.

    Directory of Open Access Journals (Sweden)

    Celeste Sassi

    Full Text Available The cerebral deposition of Aβ42, a neurotoxic proteolytic derivate of amyloid precursor protein (APP, is a central event in Alzheimer's disease (AD(Amyloid hypothesis. Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and clearance. We then used exome and genome sequencing to investigate the single independent (single-variant association test and cumulative (gene-based association test effect of coding variants in these genes as potential susceptibility factors for AD, in a cohort composed of 332 sporadic and mainly late-onset AD cases and 676 elderly controls from North America and the UK. Our study shows that common coding variability in these genes does not play a major role for the disease development. In the single-variant association analysis, the main hits, none of which statistically significant after multiple testing correction (1.9e-4APP trafficking and recycling (SORL1. These results were partially replicated in the gene-based analysis (c-alpha and SKAT tests, that reports ECE1, LYZ and TTR as nominally associated to AD (1.7e-3 APP-Aβ genes is not a critical factor for AD development and 2 Aβ degradation and clearance, rather than Aβ production, may play a key role in the etiology of sporadic AD.

  13. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease

    Science.gov (United States)

    Sassi, Celeste; Ridge, Perry G.; Nalls, Michael A.; Gibbs, Raphael; Ding, Jinhui; Lupton, Michelle K.; Troakes, Claire; Lunnon, Katie; Al-Sarraj, Safa; Brown, Kristelle S.; Medway, Christopher; Lord, Jenny; Turton, James; Morgan, Kevin; Powell, John F.; Kauwe, John S.; Cruchaga, Carlos; Bras, Jose; Goate, Alison M.; Singleton, Andrew B.; Guerreiro, Rita; Hardy, John

    2016-01-01

    The cerebral deposition of Aβ42, a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer’s disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and clearance. We then used exome and genome sequencing to investigate the single independent (single-variant association test) and cumulative (gene-based association test) effect of coding variants in these genes as potential susceptibility factors for AD, in a cohort composed of 332 sporadic and mainly late-onset AD cases and 676 elderly controls from North America and the UK. Our study shows that common coding variability in these genes does not play a major role for the disease development. In the single-variant association analysis, the main hits, none of which statistically significant after multiple testing correction (1.9e-4APP trafficking and recycling (SORL1). These results were partially replicated in the gene-based analysis (c-alpha and SKAT tests), that reports ECE1, LYZ and TTR as nominally associated to AD (1.7e-3 APP-Aβ genes is not a critical factor for AD development and 2) Aβ degradation and clearance, rather than Aβ production, may play a key role in the etiology of sporadic AD. PMID:27249223

  14. A2O-MBBR工艺在城市污水厂升级改造中的应用%AppIication of A2O-MBBR process for upgrading and reconstruction of urban wastewater treatment pIant

    Institute of Scientific and Technical Information of China (English)

    苏高强; 蒋永丰; 黄东辉; 赵勇

    2015-01-01

    In order to verify the feasibility of the application of A2/O-MBBR process for upgrading and re-construction of an urban wastewater treatment plant, a 1 m3/h pilot scale test on the stimulant wastewater treat-ment by A2/O-MBBR process was investigated. The results of the test showed that, the average mass concentra-tions of CODCr, NH3-N, TN and TP in the effluent from the device reached 37, 0.61, 10, and 0.55 mg/L respec-tively, which could basically meet the specification of grade A class 1 in GB 18918-2002 Discharge Standard of Pollutants for Municipal Wastewater Treatment Plant. It could draw a conclusion that, using A2O-MBBR process to upgrade and reconstruct urban wastewater treatment plant was feasible.%为了验证A2O-MBBR工艺在某城市污水厂提标改造应用的可行性,采用规模为1 m3/h的A2O-MBBR中试装置进行了模拟试验研究。试验结果表明,中试装置出水CODCr、 NH3-N、 TN和TP平均质量浓度可分别达到37、0.61、10、0.55 mg/L,基本满足GB 18918-2002《城镇污水处理厂污染物排放标准》一级A排放标准的要求,采用A2O-MBBR工艺用于城市污水厂提标改造是可行的。

  15. Instant EdgeSight for XenApp

    CERN Document Server

    Hasan, Vaqar

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. Instant EdgeSight for XenApp is a practical, hands-on guide that contains instruction-based examples from basic to advanced level topics. Instant EdgeSight for XenApp will serve as an excellent source of information for Citrix XenApp professionals and novices alike. It is assumed that readers have experience working with Citrix products and have some sort of familiarity with monitoring.

  16. Auxin biosynthesis and storage forms.

    Science.gov (United States)

    Korasick, David A; Enders, Tara A; Strader, Lucia C

    2013-06-01

    The plant hormone auxin drives plant growth and morphogenesis. The levels and distribution of the active auxin indole-3-acetic acid (IAA) are tightly controlled through synthesis, inactivation, and transport. Many auxin precursors and modified auxin forms, used to regulate auxin homeostasis, have been identified; however, very little is known about the integration of multiple auxin biosynthesis and inactivation pathways. This review discusses the many ways auxin levels are regulated through biosynthesis, storage forms, and inactivation, and the potential roles modified auxins play in regulating the bioactive pool of auxin to affect plant growth and development.

  17. Evaluation of COTS Rad Detection Apps

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Eric [National Security Technologies, LLC. (NSTec), Mercury, NV (United States)

    2014-02-01

    Mobile applications are currently under distribution to smart phones utilizing the built-in charge coupled-device (CCD) camera as a radiation detector. The CCD detector has a very low but measurable gamma interaction cross section so the mechanism is feasible, especially for higher dose rate environments. Given that in a large release of radioactive material these ‘crowd sourced’ measurements will be put forth for consideration, a testing and evaluation of the accuracy and uncertainty of the Apps is a critical endeavor. Not only is the accuracy of the reported measurement of concern to the immediate user’s safety, a quantitative uncertainty is required for a government response such as the Federal Radiological Monitoring and Assessment Center (FRMAC) to accept the values for consideration in the determination of regions exceeding protective action guidelines. Already, prompted by the Fukushima nuclear material releases, several repositories of this crowd-sourced data have been created (http://japan.failedrobot.com, http://www.stubbytour.com/nuc/index_en.asp, and http://www.rdtn.org) although the question remains as to the reliability of measurements incorporated into these repositories. In cases of conflict between the real-time published crowd-sourced data and governmental protective actions prepared literature should be on-hand documenting why the difference, if any, exists. Four applications for iOS devices were obtained along with hardware to benchmark their performance. Gamma/X-Ray Detector by Stephan Hotto, Geiger Camera by Senscare, and RadioactivityCounter App by Hotray LTD are all the applications available for distribution within the US that utilize the CCD camera sensor for detection of radiation levels. The CellRad app under development by Idaho National Laboratory for the Android platform was evaluated. In addition, iRad Geiger with the associated hardware accessory was also benchmarked. Radiation fields were generated in a Cs-137 JL Shepherd

  18. The Med AppJam: a model for an interprofessional student-centered mHealth app competition.

    Science.gov (United States)

    Youm, Julie; Wiechmann, Warren

    2015-03-01

    The Med AppJam is a 2-week long competition where students from the University of California, Irvine School of Medicine are partnered with students from the University of California, Irvine School of Information and Computer Sciences in interprofessional teams to develop mobile health applications for use by clinicians and patients. The success of the Med AppJam comes from the unique opportunity for students to mutually contribute their content expertise to improve the clinical landscape while expanding their technology literacy and savvy. Since 2012, about 285 computer science students and over 90 medical students have collaborated to design and develop 53 iOS mHealth apps during the event. The Med AppJam model has been replicated in an Autism AppJam, a competition focused on the needs of a specific population, and with high school students in a mini Pre-Med AppJam using a paper prototyping approach. It is proposed that other medical schools consider implementation of a local Med AppJam as a viable model for engaging students in technology for healthcare.

  19. Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.

    Science.gov (United States)

    Kundu, Arpita; Milosch, Nelli; Antonietti, Patrick; Baumkötter, Frederik; Zymny, Andreas; Müller, Ulrike C; Kins, Stefan; Hajieva, Parvana; Behl, Christian; Kögel, Donat

    2016-11-01

    Maintenance of intracellular proteostasis is essential for neuronal function, and emerging data support the view that disturbed proteostasis plays an important role in brain aging and the pathogenesis of age-related neurodegenerative disorders such as Alzheimer's disease (AD). sAPPalpha (sAPPα), the extracellularly secreted N-terminal alpha secretase cleavage product of the amyloid precursor protein (APP), has an established function in neuroprotection. Recently, we provided evidence that membrane-bound holo-APP functionally cooperates with sAPPα to mediate neuroprotection via activation of the Akt survival signaling pathway and sAPPα directly affects proteostasis. Here, we demonstrate that in addition to its anti-apoptotic function, sAPPα has effects on neuronal proteostasis under conditions of proteasomal stress. In particular, recombinant sAPPα significantly suppressed MG132-triggered expression of the co-chaperone BAG3 and aggresome formation, and it partially rescued proteasomal activity in a dose-dependent manner in SH-SY5Y neuroblastoma cells. In analogy, sAPPα was able to inhibit MG132-induced BAG3 expression in primary hippocampal neurons. Strikingly, these sAPPα-induced changes were unaltered in APP-depleted SH-SY5Y cells and APP-deficient neurons, demonstrating that holo-APP is not required for this particular function of sAPPα. Importantly, recombinant sAPPbeta (sAPPβ) failed to modulate BAG3 expression and proteostasis in APP-proficient wild-type (wt) cells, indicating that these biological effects are highly selective for sAPPα. In conclusion, we demonstrate that modulation of proteostasis is a distinct biological function of sAPPα and does not require surface-bound holo-APP. Our data shed new light on the physiological functions of APP and the interplay between APP processing and proteostasis during brain aging.

  20. 对高校移动图书馆 APP 建设的探讨%Discussion on the Construction of University Mobile Library APP

    Institute of Scientific and Technical Information of China (English)

    任海鹏

    2016-01-01

    本文从我国移动图书馆 APP 建设现状着手,重点分析了移动图书馆 APP 建设中存在的不足,进而探讨了怎样才能真正做好我国高校移动图书馆 APP 建设。%This article,from the current situation of the mobile library APP construction,focuses on the lack of construction in the presence of APP mobile library,and then discusses how to really do a good job moving APP university library construction in China.

  1. Razvoj dnevnika potovanj s pomočjo AppInventorja in AppInventor Java Bridge-a

    OpenAIRE

    Bezjak, Žan

    2016-01-01

    V diplomski nalogi smo proučili in analizirali orodje AppInventor, predstavili njegove osnove podatke, njegove prednosti in na drugi strani tudi slabosti. Poglobili smo se tudi v knjižnico AppInventor Java Bridge, ki deluje na principu že omenjenega orodja, ter v diplomskem delu izpostavili prednosti in slabosti te knjižnice. Skozi nalogo smo zgradili dve enaki aplikaciji, po eno v vsakem izmed omenjenih orodij, in na ta način preučili podobnosti oziroma razlike med orodjem AppInventor ter kn...

  2. The Quality and Accuracy of Mobile Apps to Prevent Driving After Drinking Alcohol

    Science.gov (United States)

    Stoyanov, Stoyan R; Gandabhai, Shailen; Baldwin, Alexander

    2016-01-01

    Background Driving after the consumption of alcohol represents a significant problem globally. Individual prevention countermeasures such as personalized mobile apps aimed at preventing such behavior are widespread, but there is little research on their accuracy and evidence base. There has been no known assessment investigating the quality of such apps. Objective This study aimed to determine the quality and accuracy of apps for drink driving prevention by conducting a review and evaluation of relevant mobile apps. Methods A systematic app search was conducted following PRISMA guidelines. App quality was assessed using the Mobile App Rating Scale (MARS). Apps providing blood alcohol calculators (hereafter “calculators”) were reviewed against current alcohol advice for accuracy. Results A total of 58 apps (30 iOS and 28 Android) met inclusion criteria and were included in the final analysis. Drink driving prevention apps had significantly lower engagement and overall quality scores than alcohol management apps. Most calculators provided conservative blood alcohol content (BAC) time until sober calculations. None of the apps had been evaluated to determine their efficacy in changing either drinking or driving behaviors. Conclusions This novel study demonstrates that most drink driving prevention apps are not engaging and lack accuracy. They could be improved by increasing engagement features, such as gamification. Further research should examine the context and motivations for using apps to prevent driving after drinking in at-risk populations. Development of drink driving prevention apps should incorporate evidence-based information and guidance, lacking in current apps. PMID:27502956

  3. Practical Considerations for Use of Mobile Apps at the Tactical Edge

    Science.gov (United States)

    2014-06-01

    early step toward an app store for the DoD was taken. A competition, called Apps for the Army ( A4A ), was held, and 53 apps were developed and... A4A competition—in Marketplace: 7 doctrine and publications, 4 training, 4 geospatial solutions, and 10 others. Clearly, app supply is a major issue

  4. iPad Apps That Promote Mathematical Knowledge? "Yes, They Exist!"

    Science.gov (United States)

    Larkin, Kevin

    2014-01-01

    Having trouble finding the right app? In this article, Kevin Larkin discusses the difficulties teachers encounter when searching the App Store for high quality, appropriate apps that support students' mathematical learning. Kevin provides a useful link to a collection of over 100 app reviews.

  5. Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs.

    Science.gov (United States)

    González-Tablas, Ana I; Tapiador, Juan E

    2016-05-11

    We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN) composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one to be deployed, with the aim of reusing, and possibly adapting, its security policy. We illustrate our approach through a detailed smartphone ecosystem case study. Our results suggest that the scheme can provide users with a reasonably good policy that is consistent with the user's security preferences implicitly captured by policies already in place.

  6. Bootstrapping Security Policies for Wearable Apps Using Attributed Structural Graphs

    Directory of Open Access Journals (Sweden)

    Ana I. González-Tablas

    2016-05-01

    Full Text Available We address the problem of bootstrapping security and privacy policies for newly-deployed apps in wireless body area networks (WBAN composed of smartphones, sensors and other wearable devices. We introduce a framework to model such a WBAN as an undirected graph whose vertices correspond to devices, apps and app resources, while edges model structural relationships among them. This graph is then augmented with attributes capturing the features of each entity together with user-defined tags. We then adapt available graph-based similarity metrics to find the closest app to a new one to be deployed, with the aim of reusing, and possibly adapting, its security policy. We illustrate our approach through a detailed smartphone ecosystem case study. Our results suggest that the scheme can provide users with a reasonably good policy that is consistent with the user’s security preferences implicitly captured by policies already in place.

  7. Cost Savings Associated With Pharmacy Student Interventions During APPEs

    OpenAIRE

    Shepler, Brian M.

    2014-01-01

    Objective. To quantify the impact of pharmacy students’ clinical interventions in terms of number and cost savings throughout advanced pharmacy practice experiences (APPEs) using a Web-based documentation program.

  8. CELSTEC Learning Labs: Mobile App Development for Education and Training

    NARCIS (Netherlands)

    Specht, Marcus

    2011-01-01

    Specht, M. (2011). CELSTEC Learning Labs: Mobile App Development for Education and Training. Presentation given in Workshop at CELSTEC Learning Lab for Bluetea. February, 21, 2011, Heerlen, The Netherlands.

  9. 那些神一样的App

    Institute of Scientific and Technical Information of China (English)

    金姬; 刘绮黎

    2013-01-01

    2013年5月16日,苹果App Store的App下载量突破500亿次,App数量也高达85万。为了庆祝这一历史时刻,苹果公布了App Store成立5年以来25款最畅销应用榜单。有趣的是,榜单上的许多App是早期推出的,这可能与App Store的盈利模式有关——在App Store上,一款新App下载是通常是免费的,但升级该

  10. Appreneur secrets to success in the app store

    CERN Document Server

    Pierce, Taylor

    2013-01-01

    You are interested in making an app. You have read all of the stories of successful developers and appreneurs. You are determined to get a piece of the pie. The world of apps is the fastest growing market in the world today, and it is here to stay. The best part is you can get in on it! Now what if I told you that without the knowledge contained in this book the odds of you making a profit are slim to none? What if I also told you that you probably wouldn't break even? There is more to apps than most people think. The average person assumes that if they make an app, they will instantly become

  11. Developing mental health mobile apps: Exploring adolescents' perspectives.

    Science.gov (United States)

    Kenny, Rachel; Dooley, Barbara; Fitzgerald, Amanda

    2016-06-01

    Mobile applications or 'apps' have significant potential for use in mental health interventions with adolescents. However, there is a lack of research exploring end users' needs from such technologies. The aim of this study was to explore adolescents' needs and concerns in relation to mental health mobile apps. Five focus groups were conducted with young people aged 15-16 years (N = 34, 60% male). Participants were asked about their views in relation to the use of mental health mobile technologies and were asked to give their responses to a mental health app prototype. Participants identified (1) safety, (2) engagement, (3) functionality, (4) social interaction, (5) awareness, (6) accessibility, (7) gender and (8) young people in control as important factors. Understanding end users' needs and concerns in relation to this topic will inform the future development of youth-oriented mental health apps that are acceptable to young people.

  12. Using apps for learning across the curriculum a literacy-based framework and guide

    CERN Document Server

    Beach, Richard

    2014-01-01

    How can apps be used to foster learning with literacy across the curriculum? This book offers both a theoretical framework for considering app affordances and practical ways to use apps to build students' disciplinary literacies and to foster a wide range of literacy practices.Using Apps for Learning Across the Curriculumpresents a wide range of different apps and also assesses their value features methods for and apps related to planning instruction and assessing student learning identifies favorite apps whose affordances are most likely to foster certain disciplinary literacies includes reso

  13. Transcription factors in alkaloid biosynthesis.

    Science.gov (United States)

    Yamada, Yasuyuki; Sato, Fumihiko

    2013-01-01

    Higher plants produce a large variety of low-molecular weight secondary compounds. Among them, nitrogen-containing alkaloids are the most biologically active and are often used pharmaceutically. Whereas alkaloid chemistry has been intensively investigated, alkaloid biosynthesis, including the relevant biosynthetic enzymes, genes and their regulation, and especially transcription factors, is largely unknown, as only a limited number of plant species produce certain types of alkaloids and they are difficult to study. Recently, however, several groups have succeeded in isolating the transcription factors that are involved in the biosynthesis of several types of alkaloids, including bHLH, ERF, and WRKY. Most of them show Jasmonate (JA) responsiveness, which suggests that the JA signaling cascade plays an important role in alkaloid biosynthesis. Here, we summarize the types and functions of transcription factors that have been isolated in alkaloid biosynthesis, and characterize their similarities and differences compared to those in other secondary metabolite pathways, such as phenylpropanoid and terpenoid biosyntheses. The evolution of this biosynthetic pathway and regulatory network, as well as the application of these transcription factors to metabolic engineering, is discussed.

  14. Biosynthesis and transport of terpenes

    NARCIS (Netherlands)

    Ting, H.M.

    2014-01-01

    Terpenoids are the largest class of natural product that are produced by plants, with functions that range from a role in plant development to direct defence against pathogens and indirect defence against insects through the attraction of natural enemies. While terpene biosynthesis genes have been w

  15. Characterization of the Lactococcus lactis Nisin A Operon Genes nisP, Encoding a Subtilisin-Like Serine Protease Involved in Precursor Processing, and nisR, Encoding a Regulatory Protein Involved in Nisin Biosynthesis

    NARCIS (Netherlands)

    Polman, Joyce; Beerthuyzen, Marke M.; Siezen, Roland J.; Kuipers, Oscar P.; Vos, Willem M. de

    1993-01-01

    Biosynthesis of the lantibiotic peptide nisin by Lactococcus lactis NIZO R5 relies on the presence of the conjugative transposon Tn5276 in the chromosome. A 12-kb DNA fragment of Tn5276 including the nisA gene and about 10 kb of downstream DNA was cloned in L. lactis, resulting in the production of

  16. Specialized Binary Analysis for Vetting Android APPS Using GUI Logic

    Science.gov (United States)

    2016-04-01

    effects on employee productivity and happiness . An employee may want to use a newly released app that offers many attractive timesaving features to...boost productivity . Another employee may want to use an email app she is familiar and happy with rather than using the one officially sanctioned. Both...tradeoff productivity and happiness for security. 3 METHODS, ASSUMPTIONS, AND PROCEDURES 3.1 Descriptor-Based Analysis Android uses a permission system

  17. App Store与Android Market下载排行榜

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    自从App Store中文界面推出之后,国内的Phone用户可谓异常兴奋,因为App Store带来的不仅仅是时尚,更多的是众多或功能强大,或实用有趣的软件和游戏。

  18. AppServ的安全测试

    Institute of Scientific and Technical Information of China (English)

    qapache

    2006-01-01

    AppServ是PHP网页架站工具组合包.这是一名泰国的作者将一些网络上免费的架站资源重新包装起来的安装程序.非常适合初学者快速完成架站。AppServ所包含的软件有Apache、ApacheMonitor、PHP、MYSQL、PHP—Nuke、PHPMYAdmin。

  19. APP metabolism regulates tau proteostasis in human cerebral cortex neurons

    OpenAIRE

    Steven Moore; Evans, Lewis D.B.; Therese Andersson; Erik Portelius; James Smith; Tatyana B. Dias; Nathalie Saurat; Amelia McGlade; Peter Kirwan; Kaj Blennow; John Hardy; Henrik Zetterberg; Frederick J. Livesey

    2015-01-01

    This is the final version. It was first published by Elsevier at http://www.sciencedirect.com/science/article/pii/S2211124715003599. Accumulation of Aβ peptide fragments of the APP protein and neurofibrillary tangles of the microtubule-associated protein tau are the cellular hallmarks of Alzheimer’s disease (AD). To investigate the relationship between APP metabolism and tau protein levels and phosphorylation, we studied human-stem-cell-derived forebrain neurons with genetic forms of AD, a...

  20. iPhone Location Aware Apps by Example - Beginners Guide

    CERN Document Server

    Chawdhary, Zeeshan

    2012-01-01

    Using a By example approach you will master the essentials of location awareness and augmented reality by building five complete apps using easy to follow step by step instructions geared towards newcomers. Novice to professional level iOS programmers who want to master location awareness and augmented reality. Build five practical location-based iOS Apps from scratch, a first for any book, converting learning into actual implementation.

  1. An Analysis of WhatsApp Forensics in Android Smartphones

    Directory of Open Access Journals (Sweden)

    Shubham Sahu

    2014-05-01

    Full Text Available — WhatsApp is mobile application which allows exchange of messages, videos, audio’s and images via Smartphone. The increased use of IM on Android phones has turned to be goldmine for mobile and computer forensic investigators. This paper focuses on conducting forensic data analysis by extracting useful information from WhatsApp and from similar applications installed on Android platform.

  2. Diving In To Sea Level Rise Using The Polar Explorer ';App'

    Science.gov (United States)

    Turrin, M.; Ryan, W. B.; Bell, R. E.; Pfirman, S. L.; Bell, B.; Porter, D. F.

    2013-12-01

    The vast majority of our lifetime is spent learning outside the classroom, yet the major emphasis in developing climate change instructional materials has been the traditional K16 school environment. The Polar Learning and Responding (PoLAR) project of the National Science Foundation supported Climate Change Education Partnership (CCEP) program chose to move beyond the classroom to focus on lifelong learners, in order to engage the adult population in building public understanding about climate change. Yet reaching individuals who make their own decisions about what and how they choose to learn requires a very different approach to developing educational materials. With an adult audience how we deliver content can be as critical as what we deliver. Using materials and platforms that are readily available and familiar to the user is important. With a significant segment of our time spent connected to smart phones and tablets, employing these platforms to deliver content makes sense. Whether at work, home or in transit, portable devices are critical companions and trusted tools in providing information on everything from the latest news to the daily weather. The world of Apps is equally as familiar to the adult user, so developing an engaging climate App for a portable device offers a successful strategy. The 'Polar Explorer - Sea Level Rise (SLR) App', is one of the new interactive products developed as part of the PoLAR project. Modeled after Columbia's Earth Observer App, a data exploration and data visualization tool, the Polar Explorer SLR App includes a wide range of real Earth data from ocean and atmospheric temperatures to depth of ice layers, underlying topography and human impacts. The Polar Explorer SLR App is grounded in the concept that scientists gain insights into climate change and climate processes through directly examining data. With some scaffolding, the public can gain similar insights using the same data. Structured to be 'question driven' the

  3. Molecular Evidences for the Biosynthesis of Pederin by Endosymbiont

    Institute of Scientific and Technical Information of China (English)

    LIU Zhi-ping; WU Xuan; WANG Jin-jun; HUANG Fang

    2009-01-01

    Pederin belongs to a group of antitumor compounds found in terrestrial beetles and marine sponges. It is apparently used by some members of the rove beetle Paederus as a chemical defense against predators. A recent cluster analysis of the putative pederin biosynthesis gene (ped) strongly suggests that pederin is produced by bacterial symbionts. This paper reviewed the criteria for proving symbiontic origin of bioactive metabolite, indirect and molecular evidences for pederin bacterial origin, as well as three sets ofped clusters and putative biosynthesis process of pederin.

  4. Biotin biosynthesis in Mycobacterium tuberculosis: physiology, biochemistry and molecular intervention

    Institute of Scientific and Technical Information of China (English)

    Wanisa Salaemae; Al Azhar; Grant W. Booker; Steven W. Polyak

    2011-01-01

    Biotin is an important micronutrient that serves as an essential enzyme cofactor.Bacteria obtain biotin either through de novo synthesis or by active uptake from exogenous sources.Mycobacteria are unusual amongst bacteria in that their primary source of biotin is through de novo synthesis.Here we review the importance of biotin biosynthesis in the lifecycle of Mycobacteria.Genetic screens designed to identify key metabolic processes have highlighted a role for the biotin biosynthesis in bacilli growth,infection and survival during the latency phase.These studies help to establish the biotin biosynthetic pathway as a potential drug target for new anti-tuberculosis agents.

  5. PSFC: a Pathway Signal Flow Calculator App for Cytoscape [version 1; referees: 2 approved

    Directory of Open Access Journals (Sweden)

    Lilit Nersisyan

    2015-08-01

    Full Text Available Cell signaling pathways are sequences of biochemical reactions that propagate an input signal, such as a hormone binding to a cell-surface receptor, into the cell to trigger a reactive process. Assessment of pathway activities is crucial for determining which pathways play roles in disease versus normal conditions. To date various pathway flow/perturbation assessment tools are available, however they are constrained to specific algorithms and specific data types. There are no accepted standards for evaluation of pathway activities or simulation of flow propagation events in pathways, and the results of different software are difficult to compare. Here we present Pathway Signal Flow Calculator (PSFC, a Cytoscape app for calculation of a pathway signal flow based on the pathway topology and node input data. The app provides a rich framework for customization of different signal flow algorithms to allow users to apply various approaches within a single computational framework.

  6. Smart apps for applied machine learning on mobile devices: the MOMO project

    Science.gov (United States)

    Edlich, Stefan; Vogler, Mathias

    2013-03-01

    The MOMO Project consists of the parts Mobile Computing and ECO Mobility. We present research results from a subproject of the Mobile Computing part. In particular we develop Smart-Apps for modern smartphones. These applications gather data from the owners to be filtered and processed central or distributed. The applications target persons or streams of visitors at events as e.g. concerts, amusement parks or any other official buildings. Smart Apps will work up this data, visualize it and most of all allow an intelligent prediction of the user's behavior together with recommendations. Therefore we discuss visualization strategies and the underlying machine learning concepts and applications on the mobile and on the server-side.

  7. ReadyVax: A new mobile vaccine information app.

    Science.gov (United States)

    Bednarczyk, Robert A; Frew, Paula M; Salmon, Daniel A; Whitney, Ellen; Omer, Saad B

    2017-01-06

    Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (including parents of children). We describe the information content and technical development of ReadyVax. Between the hard launch of the app on February 12, 2015 and October 8, 2016, the app has been downloaded by 5,142 unique users, with 6,841 total app sessions initiated, comprising a total of 15,491 screen views (2.3 screens/session on average). ReadyVax has been downloaded by users in 102 different countries; most users (52%) are from the United States. We are continuing outreach efforts to increase app use, and planning for development of an Android-compatible version of ReadyVax, to increase the available market for the app.

  8. THE ADOPTION STAGES OF MOBILE NAVIGATION TECHNOLOGY WAZE APP AS JAKARTA TRAFFIC JAM SOLUTION

    Directory of Open Access Journals (Sweden)

    NONI NOERKAISAR

    2016-09-01

    Full Text Available This study analyzes the adoption stages of Waze mobile navigation by using a hierarchy of effects models AIDA. Data were obtained through the survey method by means of direct interview using questionnaire instrument assistance. The results showed that there were two groups, one who have already used the Waze application and the other who have not yet used Waze application. The two groups were analyzed to see a series of Waze application adoption process. It can be seen that each stage in the adoption process affects each other. The interest of respondents to the Waze app is affected by the strengthening of awareness regarding the benefits offered by mobile navigation app Waze. The high interest of resondents continues to stage where the respondents are interested in using Waze application. At the final stage it is known that the majority of respondents who were exposed to information on uses and functions of the application Waze are willing to immediately adopt the Waze app as a mobile navigation application while driving

  9. (-)-Menthol biosynthesis and molecular genetics

    Science.gov (United States)

    Croteau, Rodney B.; Davis, Edward M.; Ringer, Kerry L.; Wildung, Mark R.

    2005-12-01

    (-)-Menthol is the most familiar of the monoterpenes as both a pure natural product and as the principal and characteristic constituent of the essential oil of peppermint ( Mentha x piperita). In this paper, we review the biosynthesis and molecular genetics of (-)-menthol production in peppermint. In Mentha species, essential oil biosynthesis and storage is restricted to the peltate glandular trichomes (oil glands) on the aerial surfaces of the plant. A mechanical method for the isolation of metabolically functional oil glands, has provided a system for precursor feeding studies to elucidate pathway steps, as well as a highly enriched source of the relevant biosynthetic enzymes and of their corresponding transcripts with which cDNA libraries have been constructed to permit cloning and characterization of key structural genes. The biosynthesis of (-)-menthol from primary metabolism requires eight enzymatic steps, and involves the formation and subsequent cyclization of the universal monoterpene precursor geranyl diphosphate to the parent olefin (-)-(4 S)-limonene as the first committed reaction of the sequence. Following hydroxylation at C3, a series of four redox transformations and an isomerization occur in a general “allylic oxidation-conjugate reduction” scheme that installs three chiral centers on the substituted cyclohexanoid ring to yield (-)-(1 R, 3 R, 4 S)-menthol. The properties of each enzyme and gene of menthol biosynthesis are described, as are their probable evolutionary origins in primary metabolism. The organization of menthol biosynthesis is complex in involving four subcellular compartments, and regulation of the pathway appears to reside largely at the level of gene expression. Genetic engineering to up-regulate a flux-limiting step and down-regulate a side route reaction has led to improvement in the composition and yield of peppermint oil.

  10. Impact of WhatsApp on Learning and Retention of Collocation Knowledge among Iranian EFL Learners

    Directory of Open Access Journals (Sweden)

    Zahra Ashiyan

    2016-10-01

    Full Text Available During the recent technological years, language learning has been attempted to transform its path from the conventional methods to instrumental applications. Mobile phone provides people to reach and exchange information through chats (WhatsApp. It is a tool or mode that means the facilities are used for main purposes. The unique features of the application are its compatibility to exchange information, enhance communication and relationship. A mobile phone provides to download, upload and store learning materials and information files. The purpose of the current study was to investigate the use and effect of mobile applications such as WhatsApp on school work and out of school work. In this way, Oxford Placement Test (OPT was conducted among 80 learners in order to select intermediate EFL learners.  In total, 60 participants whose scores were 70 or higher were elected as the intermediate level and were divided into experimental and control groups. In order to control the reliability of the collocation pretest, the test was pilot studied on 15 learners. Then, the pretest was conducted to measure the learner’s collocation knowledge in both of the groups. The experimental group frequently installed WhatsApp application in order to learning and practicing new collocations in order to learning and practicing new collocations, while the control group did not use any tool for learning them. An immediate posttest after the treatment was administered. The results in each group were statistically evaluated and the findings manifested that the experimental group who used WhatsApp application in learning collocation significantly outperformed the control group in posttest. Thus usage of WhatsApp application to acquire collocations can reinforce and enhance the process of collocations acquisition and it can guarantee retention of collocations. This study also prepares pedagogical implications for utilizing mobile application as an influential instrument

  11. Exploring Learning Performance toward Cognitive Approaches of a Virtual Companion System in LINE App for m-Learning

    Science.gov (United States)

    Hsieh, Sheng-Wen; Wu, Min-Ping

    2013-01-01

    This paper used a Virtual Companion System (VCS) to examine how specific design variables within virtual learning companion affect the learning process of learners as defined by the cognitive continuum of field-dependent, field-independent and field-mixed learners in LINE app for m-learning. The data were collected from 198 participants in a…

  12. Development of an IOS App Using Situated Learning, Communities of Practice, and Augmented Reality for Autism Spectrum Disorder

    Science.gov (United States)

    Clarkson, Jessica

    2014-01-01

    This paper presents the development process and framework used to construct a transportation app that uses situated learning, augmented reality, and communities of practice. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause social impairments as well as the limit the potential for the individual to achieve independence…

  13. Biosynthesis of Nitrogenase FeMoco.

    Science.gov (United States)

    Hu, Yilin; Ribbe, Markus W

    2011-05-01

    Biosynthesis of nitrogenase FeMoco is a highly complex process that requires, minimally, the participation of nifS, nifU, nifB, nifE, nifN, nifV, nifH, nifD and nifK gene products. Previous genetic analyses have identified the essential factors for the assembly of FeMoco; however, the exact functions of these factors and the precise sequence of events during the assembly process had remained unclear until recently, when a number of the biosynthetic intermediates of FeMoco were identified and characterized by combined biochemical, spectroscopic and structural analyses. This review gives a brief account of the recent progress toward understanding the assembly process of FeMoco, which has identified some important missing pieces of this biosynthetic puzzle.

  14. Mobile telephone apps in mental health practice: uses, opportunities and challenges

    OpenAIRE

    Marley, Justin; Farooq, Saeed

    2015-01-01

    Smartphones are used by patients and clinicians alike. Vast numbers of software applications (apps) run on smartphones and carry out useful functions. Clinician- and patient-oriented mental health apps have been developed. In this article, we provide an overview of apps that are relevant for mental health. We look at clinician-oriented apps that support assessment, diagnosis and treatment as well as patient-oriented apps that support education and self-management. We conclude by looking at th...

  15. mHealth in Urology: A Review of Experts' Involvement in App Development.

    Directory of Open Access Journals (Sweden)

    Nuno Pereira-Azevedo

    Full Text Available Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP and scientific Urology associations in their development.A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development.The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7% and only a third had been developed with a scientific Urology association (34.7%. The lowest percentage of HCP (13.4% and urological association (1.9% involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed.Despite the increasing Mobile Health (mHealth market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation.

  16. The MapApp Virtual Seabed Explorer

    Science.gov (United States)

    Haxby, W. F.; Ryan, W. B.; Carbotte, S. M.

    2003-12-01

    MapApp is a downloadable, open source, prototype client application running in a desktop personal computing environment with the capability to explore two hundred million years of global ocean floor geology and geochemistry. It accomplishes the exploration and discovery in an integrated data environment of bathymetry, gravity, magnetic anomalies, reflection profiles, crustal ages, sediment composition, bedrock petrology and chemistry. Exploration is undertaken in a single visual interface with spawned windowpanes that communicate with each other. These panes provide the viewport for charting subsea landscapes, the spreadsheet for examination and manipulation of data discovered either by direct encounter or by query, the notebook for recording and downloading either original data or derived products, and dialog boxes to set parameters for models. All data are real measurements and their metadata reside in relational databases. The data come from decades of marine geological and geophysical surveys, coring, dredging, deep-sea drilling, and submersible dives. The lessons learned include the importance of rigorous data management, the need for quality-control of data accuracy, the discipline to keep the interface simple and intuitive, and the requirement to be functional over large scales of variable spatial and temporal resolution. A technical challenge is the programming difficulties presented by continuously changing versions of the PC client operating systems. The greatest scientific challenge is cost-effective mining of published textural data and convincing competitive researchers to contribute their data that is often already many years old. To retain and expand the user community of students, educators and researchers, we are discovering that it is equally as important to grow content as to add functionality.

  17. Privacy as Part of the App Decision-Making Process

    Science.gov (United States)

    2013-02-06

    formation through permissions and then sending that data off phone [5]. Vidas et al. also studied how applications request permis- sions, finding...bold, Fisher’s Exact. Comparisons with the Android display were planned contrasts. The final comparison between the permissions inline and privacy...access control. ACM Trans. Comput.-Hum. Interact. 16, 3 (Sept. 2009), 12:1–12:26. 25. Vidas , T., Christin, N., and Cranor, L. F. Curbing android permission creep. In W2SP 2011 (2011). 11

  18. mHealth in Urology: A Review of Experts’ Involvement in App Development

    Science.gov (United States)

    Pereira-Azevedo, Nuno; Carrasquinho, Eduardo; Cardoso de Oliveira, Eduardo; Cavadas, Vitor; Osório, Luís; Fraga, Avelino; Castelo-Branco, Miguel; Roobol, Monique J.

    2015-01-01

    Introduction Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. Material and Methods A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app’s platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. Results The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Conclusions Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation. PMID:25984916

  19. IDEAS and App Development Internship in Hardware and Software Design

    Science.gov (United States)

    Alrayes, Rabab D.

    2016-01-01

    In this report, I will discuss the tasks and projects I have completed while working as an electrical engineering intern during the spring semester of 2016 at NASA Kennedy Space Center. In the field of software development, I completed tasks for the G-O Caching Mobile App and the Asbestos Management Information System (AMIS) Web App. The G-O Caching Mobile App was written in HTML, CSS, and JavaScript on the Cordova framework, while the AMIS Web App is written in HTML, CSS, JavaScript, and C# on the AngularJS framework. My goals and objectives on these two projects were to produce an app with an eye-catching and intuitive User Interface (UI), which will attract more employees to participate; to produce a fully-tested, fully functional app which supports workforce engagement and exploration; to produce a fully-tested, fully functional web app that assists technicians working in asbestos management. I also worked in hardware development on the Integrated Display and Environmental Awareness System (IDEAS) wearable technology project. My tasks on this project were focused in PCB design and camera integration. My goals and objectives for this project were to successfully integrate fully functioning custom hardware extenders on the wearable technology headset to minimize the size of hardware on the smart glasses headset for maximum user comfort; to successfully integrate fully functioning camera onto the headset. By the end of this semester, I was able to successfully develop four extender boards to minimize hardware on the headset, and assisted in integrating a fully-functioning camera into the system.

  20. BIOSYNTHESIS AND ACTION OF JASMONATES IN PLANTS.

    Science.gov (United States)

    Creelman, Robert A.; Mullet, John E.

    1997-06-01

    Jasmonic acid and its derivatives can modulate aspects of fruit ripening, production of viable pollen, root growth, tendril coiling, and plant resistance to insects and pathogens. Jasmonate activates genes involved in pathogen and insect resistance, and genes encoding vegetative storage proteins, but represses genes encoding proteins involved in photosynthesis. Jasmonic acid is derived from linolenic acid, and most of the enzymes in the biosynthetic pathway have been extensively characterized. Modulation of lipoxygenase and allene oxide synthase gene expression in transgenic plants raises new questions about the compartmentation of the biosynthetic pathway and its regulation. The activation of jasmonic acid biosynthesis by cell wall elicitors, the peptide systemin, and other compounds will be related to the function of jasmonates in plants. Jasmonate modulates gene expression at the level of translation, RNA processing, and transcription. Promoter elements that mediate responses to jasmonate have been isolated. This review covers recent advances in our understanding of how jasmonate biosynthesis is regulated and relates this information to knowledge of jasmonate modulated gene expression.

  1. Heparan sulfate biosynthesis

    DEFF Research Database (Denmark)

    Multhaupt, Hinke A B; Couchman, John R

    2012-01-01

    that the synthesis of heparan sulfate is tightly controlled. Although genomics has identified the enzymes involved in glycosaminoglycan synthesis in a number of vertebrates and invertebrates, the regulation of the process is not understood. Moreover, the localization of the various enzymes in the Golgi apparatus has...... not been carried out in a detailed way using high-resolution microscopy. We have begun this process, using well-known markers for the various Golgi compartments, coupled with the use of characterized antibodies and cDNA expression. Laser scanning confocal microscopy coupled with line scanning provides high......-quality resolution of the distribution of enzymes. The EXT2 protein, which when combined as heterodimers with EXT1 comprises the major polymerase in heparan sulfate synthesis, has been studied in depth. All the data are consistent with a cis-Golgi distribution and provide a starting point to establish whether all...

  2. Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks

    Science.gov (United States)

    Wiencko, Heather L.; Bernal-Llinares, Manuel; Bryan, Kenneth; Lynn, David J.

    2016-01-01

    Highly connected nodes (hubs) in biological networks are topologically important to the structure of the network and have also been shown to be preferentially associated with a range of phenotypes of interest. The relative importance of a hub node, however, can change depending on the biological context. Here, we report a Cytoscape app, the Contextual Hub Analysis Tool (CHAT), which enables users to easily construct and visualize a network of interactions from a gene or protein list of interest, integrate contextual information, such as gene expression or mass spectrometry data, and identify hub nodes that are more highly connected to contextual nodes (e.g. genes or proteins that are differentially expressed) than expected by chance. In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. The top 20 degree-based hubs were enriched in pathways related to the cell cycle and cancer, which is likely due to the fact that proteins involved in these processes tend to be highly connected in general. In comparison, the top 20 contextual hubs were enriched in pathways commonly observed in a viral infection including pathways related to the immune response to viral infection. This analysis shows that such contextual hubs are considerably more biologically relevant than degree-based hubs and that analyses which rely on the identification of hubs solely based on their connectivity may be biased towards nodes that are highly connected in general rather than in the specific context of interest. Availability: CHAT is available for Cytoscape 3.0+ and can be installed via the Cytoscape App Store ( http://apps.cytoscape.org/apps/chat). PMID:27853512

  3. Glycosaminoglycan Biosynthesis in Zebrafish

    OpenAIRE

    Filipek-Górniok, Beata

    2015-01-01

    Proteoglycans (PGs) are composed of highly sulfated glycosaminoglycans chains (GAGs) attached to specific core proteins. They are present in extracellular matrices, on the cell surface and in storage granules of hematopoietic cells. Heparan sulfate (HS) and chondroitin/dermatan sulfate (CS/DS) GAGs play indispensable roles in a wide range of biological processes, where they can serve as protein carriers, be involved in growth factor or morphogen gradient formation and act as co-receptors in s...

  4. Gibberellin biosynthesis in Gibberlla fujikuroi

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, S.W.; Coolbaugh, R.C. (Iowa State Univ., Ames (USA))

    1989-04-01

    Gibberellins (GAs) are a group of plant growth hormones which were first isolated from the fungus Gibberella fujikuori. We have examined the biosynthesis of GAs in this fungus in liquid cultures using HPLC followed by GC-MS. Furthermore we have used cell-free enzyme extracts with {sup 14}C-labeled intermediates to examine the regulation of specific parts of the biosynthetic pathway. GA{sub 3} is the predominant GA in well aerated cultures. GA{sub 4} and GA{sub 7}, intermediates in GA{sub 3} biosynthesis, accumulate in cultures with low levels of dissolved oxygen, but are not detectable in more aerated cultures. Light stimulates GA production in G. fujikuroi cultures grown from young stock. Cell-free enzyme studies indicate that light has no effect on incorporation of mevalonic acid into kaurene, but does significantly stimulate the oxidation of kaurenoic acid.

  5. Comparative Proteomic Analysis Reveals Proteins Putatively Involved in Toxin Biosynthesis in the Marine Dinoflagellate Alexandrium catenella

    Directory of Open Access Journals (Sweden)

    Da-Zhi Wang

    2013-01-01

    Full Text Available Alexandrium is a neurotoxin-producing dinoflagellate genus resulting in paralytic shellfish poisonings around the world. However, little is known about the toxin biosynthesis mechanism in Alexandrium. This study compared protein profiles of A. catenella collected at different toxin biosynthesis stages (non-toxin synthesis, initial toxin synthesis and toxin synthesizing coupled with the cell cycle, and identified differentially expressed proteins using 2-DE and MALDI-TOF-TOF mass spectrometry. The results showed that toxin biosynthesis of A. catenella occurred within a defined time frame in the G1 phase of the cell cycle. Proteomic analysis indicated that 102 protein spots altered significantly in abundance (P < 0.05, and 53 proteins were identified using database searching. These proteins were involved in a variety of biological processes, i.e., protein modification and biosynthesis, metabolism, cell division, oxidative stress, transport, signal transduction, and translation. Among them, nine proteins with known functions in paralytic shellfish toxin-producing cyanobacteria, i.e., methionine S-adenosyltransferase, chloroplast ferredoxin-NADP+ reductase, S-adenosylhomocysteinase, adenosylhomocysteinase, ornithine carbamoyltransferase, inorganic pyrophosphatase, sulfotransferase (similar to, alcohol dehydrogenase and arginine deiminase, varied significantly at different toxin biosynthesis stages and formed an interaction network, indicating that they might be involved in toxin biosynthesis in A. catenella. This study is the first step in the dissection of the behavior of the A. catenella proteome during different toxin biosynthesis stages and provides new insights into toxin biosynthesis in dinoflagellates.

  6. Pro iOS Geo building apps with location based services

    CERN Document Server

    Andreucci, Giacomo

    2013-01-01

    Deepen your app development skills with Pro iOS Geo. This book shows you how to use geolocation-based tools to enhance the iOS apps you develop. Author Giacomo Andreucci describes different ways to integrate geo services, depending on the kind of app you're looking to develop: a web app, a hybrid app, or a native app. You'll discover how to use the Google Maps API features to integrate powerful geo capabilities in your apps with a little effort. You'll learn how to: Design geographic features for your apps while respecting usability criteria Design touristic geo apps Use HTML5 and the Google M

  7. APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

    Directory of Open Access Journals (Sweden)

    Hilla Fogel

    2014-06-01

    Full Text Available Accumulation of amyloid-β peptides (Aβ, the proteolytic products of the amyloid precursor protein (APP, induces a variety of synaptic dysfunctions ranging from hyperactivity to depression that are thought to cause cognitive decline in Alzheimer’s disease. While depression of synaptic transmission has been extensively studied, the mechanisms underlying synaptic hyperactivity remain unknown. Here, we show that Aβ40 monomers and dimers augment release probability through local fine-tuning of APP-APP interactions at excitatory hippocampal boutons. Aβ40 binds to the APP, increases the APP homodimer fraction at the plasma membrane, and promotes APP-APP interactions. The APP activation induces structural rearrangements in the APP/Gi/o-protein complex, boosting presynaptic calcium flux and vesicle release. The APP growth-factor-like domain (GFLD mediates APP-APP conformational changes and presynaptic enhancement. Thus, the APP homodimer constitutes a presynaptic receptor that transduces signal from Aβ40 to glutamate release. Excessive APP activation may initiate a positive feedback loop, contributing to hippocampal hyperactivity in Alzheimer’s disease.

  8. Geosocial Networking App Use Among Men Who Have Sex With Men in Serious Romantic Relationships.

    Science.gov (United States)

    Macapagal, Kathryn; Coventry, Ryan; Puckett, Jae A; Phillips, Gregory; Mustanski, Brian

    2016-08-01

    Geosocial networking (GSN) mobile phone applications ("apps") are used frequently among men who have sex with men (MSM) to socialize and meet sexual partners. Though GSN apps are used by some MSM in partnered relationships, little is known about how the use of GSN apps among MSM in serious romantic relationships can influence couples' sexual and relationship health. MSM in serious relationships (N = 323; M age = 40 years) were recruited through a popular GSN app for MSM. Participants completed open-ended items regarding the costs and benefits of app use to their relationships, discussions of app use with their partners, and preferences for relationship education related to app use. Reported benefits of app use included improving sex and communication with one's primary partner and fulfilling unmet sexual needs. Although approximately half had not discussed app use with their partners, citing app use as a "non-issue," many cited various drawbacks to app use, including jealousy and being a distraction from the relationship. Few described sexual health concerns as a drawback to meeting partners through apps. Regarding relationship education preferences, most wanted help with general communication skills and how to express one's sexual needs to a partner. Although GSN app use can enhance relationships and sex among partnered MSM, unclear communication about app use may contribute to negative relationship outcomes and could prevent partners from having sexual needs met. Relationship and sexual health education programs for male couples should consider addressing social media and technology use in their curricula.

  9. The challenges of co-developing a behaviour change app that aimed to make physical activity a habit

    Directory of Open Access Journals (Sweden)

    Alice S Forster

    2016-01-01

    Developers of behaviour change apps must balance the demands of users that will make using the app a habit, while retaining the ingredients necessary for the app to achieve its purpose. Mixed methods provide a rich data set with which to base app development and greater confidence that the app will meet the needs of users in terms of social networking and privacy.

  10. [Biosynthesis of adipic acid].

    Science.gov (United States)

    Han, Li; Chen, Wujiu; Yuan, Fei; Zhang, Yuanyuan; Wang, Qinhong; Ma, Yanhe

    2013-10-01

    Adipic acid is a six-carbon dicarboxylic acid, mainly for the production of polymers such as nylon, chemical fiber and engineering plastics. Its annual demand is close to 3 million tons worldwide. Currently, the industrial production of adipic acid is based on the oxidation of aromatics from non-renewable petroleum resources by chemo-catalytic processes. It is heavily polluted and unsustainable, and the possible alternative method for adipic acid production should be developed. In the past years, with the development of synthetic biology and metabolic engineering, green and clean biotechnological methods for adipic acid production attracted more attention. In this study, the research advances of adipic acid and its precursor production are reviewed, followed by addressing the perspective of the possible new pathways for adipic acid production.

  11. Biosynthesis of pectin

    DEFF Research Database (Denmark)

    Scheller, Henrik Vibe; Jensen, Jacob Krüger; Sørensen, Susanne Oxenbøll

    2007-01-01

    Pectin consists of a group of acidic polysaccharides that constitute a large part of the cell wall of plants. The pectic polysaccharides have a complex structure but can generally be divided into homogalacturonan, rhamnogalacturonan I, rhamnogalacturonan II (RGII) and xylogalacturonan (XGA......). These polysaccharides appear to be present in all cells but their relative abundance and structural details differ between cell types and species. Pectin is synthesized in the Golgi vesicles and its complexity dictates that a large number of enzymes must be involved in the process. The biosynthetic enzymes required...... are glycosyltransferases and decorating enzymes including methyltransferases, acetyltransferases and feruloyltransferases. Biochemical methods successfully led to the recent identification of a pectin biosynthetic galacturonosyltransferase (GAUT1), and recent functional genomics and mutant studies have allowed...

  12. Building cross-platform apps using Titanium, Alloy, and Appcelerator cloud services

    CERN Document Server

    Saunders, Aaron

    2014-01-01

    Skip Objective-C and Java to get your app to market faster, using the skills you already have Building Cross-Platform Apps using Titanium, Alloy, and Appcelerator Cloud Services shows you how to build cross-platform iOS and Android apps without learning Objective-C or Java. With detailed guidance given toward using the Titanium Mobile Platform and Appcelerator Cloud Services, you will quickly develop the skills to build real, native apps- not web apps-using existing HTML, CSS, and JavaScript know-how. This guide takes you step-by-step through the creation of a photo-sharing app that leverages

  13. Android arcade game app a real world project : case study approach

    CERN Document Server

    DiMarzio, Jerome

    2012-01-01

    Apress, the leading Android books publisher, continues to provide you with very hands-on, practical books for teaching and showing app developers how to build and design apps, including game apps, that can be built and deployed in the various Android app stores out there. Android Arcade Game App:  A Real World Project - Case Study Approach is no different in that it walks you through creating an arcade style Prison Break game app-top to bottom-for an Android smartphone or tablet.  This book teaches you the unique characteristics and challenges of creating an Arcade style game And it provides y

  14. Mobile telephone apps in mental health practice: uses, opportunities and challenges.

    Science.gov (United States)

    Marley, Justin; Farooq, Saeed

    2015-12-01

    Smartphones are used by patients and clinicians alike. Vast numbers of software applications (apps) run on smartphones and carry out useful functions. Clinician- and patient-oriented mental health apps have been developed. In this article, we provide an overview of apps that are relevant for mental health. We look at clinician-oriented apps that support assessment, diagnosis and treatment as well as patient-oriented apps that support education and self-management. We conclude by looking at the challenges that apps pose with a discussion of possible solutions.

  15. Start App: a coding experience between primary and secondary school

    Directory of Open Access Journals (Sweden)

    Filippo Bruni

    2016-04-01

    Full Text Available The paper presents a coding experience in primary school (“Colozza” in Campobasso. Within the theoretical framework offered by computational thinking, using App Inventor, it was created a calculator for smartphone in the Android environment. High school students (from a technical secondary school guided the pupils in primary school, making an interesting form of cooperation between primary and secondary schools. Start App: una esperienza di coding tra scuola primaria e scuola secondariaIl contributo presenta una esperienza di coding nella scuola primaria dell’Istituto Comprensivo statale “Colozza” di Campobasso. All’interno della cornice teorica offerta dal pensiero computazionale, utilizzando App Inventor, è stata realizzata una calcolatrice per smartphone in ambiente Android. A guidare gli allievi della primaria sono stati gli studenti dell’Istituto Tecnico Industriale “Marconi” di Campobasso realizzando una interessante forma di collaborazione tra istituti scolastici di ordine diverso.

  16. Topic Space: Rapid Prototyping a Mobile Augmented Reality Recommendation App

    Directory of Open Access Journals (Sweden)

    Jim Hahn

    2015-10-01

    Full Text Available With funding from an Institute of Museum and Library Services (IMLS Sparks! Ignition Grant, researchers from the University of Illinois Library designed and tested a mobile recommender app with augmented reality features. By embedding open source optical character recognition software into a “Topic Space” module, the augmented reality app can recognize call numbers on a book in the library and suggest relevant items that are not shelved nearby. Topic Space can also show users items that are normally shelved in the starting location but that are currently checked out. Using formative UX methods, grant staff shaped app interface and functionality through early user testing. This paper reports results of UX testing; a redesigned mobile interface, and provides considerations on the future development of personalized recommendation functionality.

  17. A Comprehensive Evaluation Rubric for Assessing Instructional Apps

    Directory of Open Access Journals (Sweden)

    Cheng-Yuan Lee

    2015-01-01

    Full Text Available There is a pressing need for an evaluation rubric that examines all aspects of educational apps designed for instructional purposes. In past decades, many rubrics have been developed for evaluating educational computer-based programs; however, rubrics designed for evaluating the instructional implications of educational apps are scarce. When an Internet search for existing rubrics was conducted, only two such rubrics were found, and the evaluation criteria used in those rubrics was not clearly linked to previously conducted research nor were their evaluative dimensions clearly defined. These shortcomings result in reviewers being unable to use those rubrics to provide teachers with a precise analysis of an educational app’s instructional potential. In response, this paper presents a comprehensive rubric with 24-evaluative dimensions tailored specifically to analyze the educational potential of instructional apps.

  18. Hydrogen Sulfide Selectively Inhibits γ-Secretase Activity and Decreases Mitochondrial Aβ Production in Neurons from APP/PS1 Transgenic Mice.

    Science.gov (United States)

    Zhao, Feng-Li; Qiao, Pei-Feng; Yan, Ning; Gao, Dan; Liu, Meng-Jie; Yan, Yong

    2016-05-01

    Hydrogen sulfide (H2S) is now considered to be a gasotransmitter and may be involved in the pathological process of Alzheimer's disease (AD). A majority of APP is associated with mitochondria and is a substrate for the mitochondrial γ-secretase. The mitochondria-associated APP metabolism where APP intracellular domains (AICD) and Aβ are generated locally and may contribute to mitochondrial dysfunction in AD. Here, we aimed to investigate the ability of H2S to mediate APP processing in mitochondria and assessed the possible mechanisms underlying H2S-mediated AD development. We treated neurons from APP/PS1 transgenic mice with a range of sodium hydrosulfide (NaHS) concentrations. NaHS attenuated APP processing and decreased Aβ production in mitochondria. Meanwhile, NaHS did not changed BACE-1 and ADAM10 (a disintegrin and metalloprotease 10) protein levels, but NaHS (30 μM) significantly increased the levels of presenilin 1(PS1), PEN-2, and NCT, as well as improved the γ-secretase activity, while NaHS (50 μM) exhibits the opposing effects. Furthermore, the intracellular ATP and the COX IV activity of APP/PS1 neurons were increased after 30 μM NaHS treatment, while the ROS level was decreased and the MMP was stabilized. The effect of NaHS differs from DAPT (a non-selective γ-secretase inhibitor), and it selectively inhibited γ-secretase in vitro, without interacting with Notch and modulating its cleavage. The results indicated that NaHS decreases Aβ accumulation in mitochondria by selectively inhibiting γ-secretase. Thus, we provide a mechanistic view of NaHS is a potential anti-AD drug candidate and it may decrease Aβ deposition in mitochondria by selectively inhibiting γ-secretase activity and therefore protecting the mitochondrial function during AD conditions.

  19. Realtime Space Weather Forecasts Via Android Phone App

    Science.gov (United States)

    Crowley, G.; Haacke, B.; Reynolds, A.

    2010-12-01

    For the past several years, ASTRA has run a first-principles global 3-D fully coupled thermosphere-ionosphere model in real-time for space weather applications. The model is the Thermosphere-Ionosphere Mesosphere Electrodynamics General Circulation Model (TIMEGCM). ASTRA also runs the Assimilative Mapping of Ionospheric Electrodynamics (AMIE) in real-time. Using AMIE to drive the high latitude inputs to the TIMEGCM produces high fidelity simulations of the global thermosphere and ionosphere. These simulations can be viewed on the Android Phone App developed by ASTRA. The SpaceWeather app for the Android operating system is free and can be downloaded from the Google Marketplace. We present the current status of realtime thermosphere-ionosphere space-weather forcasting and discuss the way forward. We explore some of the issues in maintaining real-time simulations with assimilative data feeds in a quasi-operational setting. We also discuss some of the challenges of presenting large amounts of data on a smartphone. The ASTRA SpaceWeather app includes the broadest and most unique range of space weather data yet to be found on a single smartphone app. This is a one-stop-shop for space weather and the only app where you can get access to ASTRA’s real-time predictions of the global thermosphere and ionosphere, high latitude convection and geomagnetic activity. Because of the phone's GPS capability, users can obtain location specific vertical profiles of electron density, temperature, and time-histories of various parameters from the models. The SpaceWeather app has over 9000 downloads, 30 reviews, and a following of active users. It is clear that real-time space weather on smartphones is here to stay, and must be included in planning for any transition to operational space-weather use.

  20. Biosurfactant Mediated Biosynthesis of Selected Metallic Nanoparticles

    Directory of Open Access Journals (Sweden)

    Grażyna A. Płaza

    2014-08-01

    Full Text Available Developing a reliable experimental protocol for the synthesis of nanomaterials is one of the challenging topics in current nanotechnology particularly in the context of the recent drive to promote green technologies in their synthesis. The increasing need to develop clean, nontoxic and environmentally safe production processes for nanoparticles to reduce environmental impact, minimize waste and increase energy efficiency has become essential in this field. Consequently, recent studies on the use of microorganisms in the synthesis of selected nanoparticles are gaining increased interest as they represent an exciting area of research with considerable development potential. Microorganisms are known to be capable of synthesizing inorganic molecules that are deposited either intra- or extracellularly. This review presents a brief overview of current research on the use of biosurfactants in the biosynthesis of selected metallic nanoparticles and their potential importance.

  1. Lignin biosynthesis and its molecular regulation

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    Lignin biosynthesis has become increasingly highlighted because it plays an important role in the growth and development of plant, in the systematic evolution of plant and in the human life. Due to the progress in the field of lignin studies in recent years, the lignin biosynthesis pathway has been 修订日期:. Here we discuss some genetic engineering approaches on lignin biosynthesis, and conceive strategy to regulate lignin biosynthesis in order to use lignin resource more efficiently in agricultural and industrial productions.

  2. Google Script Adding Functionality to Your Google Apps

    CERN Document Server

    Ferreira, James

    2012-01-01

    How can you extend Google Apps to fit your organization's needs? This concise guide shows you how to use Google Scripts, the JavaScript-based language that provides a complete web-based development platform-with no downloads, configuration, or compiling required. You'll learn how to add functionality to Gmail, spreadsheets, and other Google services, or build data-driven apps that run from a spreadsheet, in a browser window, or within a Google Site. If you have some Java experience, getting started with Google Scripts is easy. Through code examples and step-by-step instructions, you'll learn

  3. A Smartphone APP for Health and Tourism Promotion

    Directory of Open Access Journals (Sweden)

    Ker-Cheng Lin

    2014-01-01

    Full Text Available The main purpose of this study is to develop an APP by integrating GPS to provide the digitized information of local cultural spots to guide tourists for tourism promotion and the digitized information of mountaineering trails to monitor energy expenditure (EE for health promotion. The provided cultural information is also adopted for educational purpose. Extended Technology Acceptance Model (TAM was used to evaluate the usefulness and behavior intention of the provided information and functions in the developed system. Most users agreed that the system is useful for health promotion, tourism promotion, and folk-culture education. They also showed strong intention and positive attitude toward continuous use of the APP.

  4. App Inventor接口开发三例

    Institute of Scientific and Technical Information of China (English)

    杨晓黎

    2016-01-01

    Google App Inventor是一个基于浏览器的在线Android开发编程环境,抛弃复杂的程式代码而使用积木式的堆叠法来完成了Android程式.编程容易,上手快,适合没有任何开发经验的用户.但在使用的过程中,发现有一些局限性,如数据库,动态组件等,通过3个接口案例,大大扩展了App Inventor的功能.

  5. Field Geologist: An Android App for Measuring Rock Outcroppings

    Science.gov (United States)

    Baird, J.; Chiu, M. T.; Huang, X.; de Lanerolle, T. R.; Morelli, R.; Gourley, J. R.

    2011-12-01

    Field geologist is a mobile Android app that measures, plots, and exports strike and data in the field. When the phone is placed on the steepest part of the rock, it automatically detects dip, string, latitude and longitude. It includes a drop-down menu to record the type of rock. The app's initial screen displays a compass with an interior dip/strike symbol that always points toward the dip direction. Tapping the compass stores a data point in the phone's database. The points can be displayed on a Google map and uploaded to a server, from where they can be retrieved in CSV format and imported into a spreadsheet.

  6. Localizing apps a practical guide for translators and translation students

    CERN Document Server

    Roturier, Johann

    2015-01-01

    The software industry has undergone rapid development since the beginning of the twenty-first century. These changes have had a profound impact on translators who, due to the evolving nature of digital content, are under increasing pressure to adapt their ways of working. Localizing Apps looks at these challenges by focusing on the localization of software applications, or apps. In each of the five core chapters, Johann Roturier examines:The role of translation and other linguistic activities in adapting software to the needs of different cultures (localization);The procedures required to prep

  7. Developing a smartphone app to support the nursing community.

    Science.gov (United States)

    Colton, Scott; Hunt, Louise

    2016-02-01

    Healthcare professionals are turning increasingly to the digital sector to access information they need for their work. Mobile technology, such as smartphones and tablets, provides a unique opportunity to place high-quality information directly into users' hands. This article describes the ongoing development of a smartphone app, Preparing for Caring, designed to prepare the future workforce by enabling mentors and nursing students to access supportive material during practice-based learning episodes. The article explores the rationale for designing the app and discusses the challenges and benefits of developing this resource from the perspectives of student, mentor and healthcare manager.

  8. Learn to read and write: app for the literacy learning

    Directory of Open Access Journals (Sweden)

    Raquel GÓMEZ-DÍAZ

    2015-12-01

    Full Text Available Increasing tablets and educational apps aimed at kids made necessary, besides analyzing the advantages and disadvantages of their use in the classroom, have a better understanding of the applications themselves, their characteristics, business models, etc. The article focuses on the apps intended for literacy learning, and offers, along with a typology, and a selection of some of them. Finally, it includes a list of sources that will help teachers in the task of selecting the most suitable for the needs of pupils’ applications.

  9. Exploring the Materiality of Literary Apps for Children

    DEFF Research Database (Denmark)

    Henkel, Ayoe Qvist

    2016-01-01

    Children’s literature is increasingly being realized in app format, with its possibilities of combining text, music, sound effects, stills, animated movies, verbal language, and, not least, interactivity. This digital and medial literary development calls for new analytical approaches to explore...... its manifestation in children’s literature – its materiality in particular. Exploring and analyzing the app Sofus and the Moonmachine by Burup, Jensen, Skovmand, and Vedel (2016), which integrates various art forms and sensory appeals and prompts different reading paths and types of interaction...

  10. Best book on iOS app marketing

    CERN Document Server

    Amerson, Michael

    2012-01-01

    Mike Amerson, Co-Founder and President of WET Productions, Inc., learned the hard lesson that many developers face today: just because you built it, doesn't mean they will come. His game ""My Virtual Girlfriend"" went nine months with only modest sales until late in December of 2010, when he gathered what he'd learned about app discoverability and used it to propel the game to the Top 100 list for its category. Furthermore, the game has only gained momentum, sitting in the Top 25 for over a year. Though Mike overcame the challenges of app development, he knows exactly what it's like for a

  11. Best iPad Apps The Guide for Discriminating Downloaders

    CERN Document Server

    Meyers, Peter

    2010-01-01

    What really wows iPad fans is when their touchscreen does what's impossible on other gadgets: the finger-painting app that turns a cross-country flight into a moving art class, the mini music studio (two-dozen instruments strong, each with motion-induced warble effects), and the portable fireworks display that you sculpt by swiping. Problem is, with tens of thousands of apps available for your iPad, who knows what to download? You can try to sort through a gazillion customer reviews with a mix of 5- and 1-star ratings, but that's a head-hurting time-waster. The stakes are getting higher, too

  12. Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.

    Science.gov (United States)

    Wang, Yajie; Wu, Fengyi; Pan, Haining; Zheng, Wenzhong; Feng, Chi; Wang, Yunfu; Deng, Zixin; Wang, Lianrong; Luo, Jie; Chen, Shi

    2016-02-29

    Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain. Aβ plaques are produced through sequential β/γ cleavage of amyloid precursor protein (APP), of which there are three main APP isoforms: APP695, APP751 and APP770. KPI-APPs (APP751 and APP770) are known to be elevated in AD, but the reason remains unclear. Transcription activator-like (TAL) effector nucleases (TALENs) induce mutations with high efficiency at specific genomic loci, and it is thus possible to knock out specific regions using TALENs. In this study, we designed and expressed TALENs specific for the C-terminus of APP in HeLa cells, in which KPI-APPs are predominantly expressed. The KPI-APP mutants lack a 12-aa region that encompasses a 5-aa trans-membrane (TM) region and 7-aa juxta-membrane (JM) region. The mutated KPI-APPs exhibited decreased mitochondrial localization. In addition, mitochondrial morphology was altered, resulting in an increase in spherical mitochondria in the mutant cells through the disruption of the balance between fission and fusion. Mitochondrial dysfunction, including decreased ATP levels, disrupted mitochondrial membrane potential, increased ROS generation and impaired mitochondrial dehydrogenase activity, was also found. These results suggest that specific regions of KPI-APPs are important for mitochondrial localization and function.

  13. Spatial Thinking and Visualisation of Real-World Concepts using GeoMapApp

    Science.gov (United States)

    Goodwillie, A. M.

    2015-12-01

    Commonly, geoscience data is presented to students in the lab and classroom in the form of data tables, maps and graphs. Successful data interpretation requires learners to become proficient with spatial thinking skills, allowing them to gain insight and understanding of the underlying real-world 3-D processes and concepts. Yet, educators at both the school and university level often witness students having difficulty in performing that translation. As a result, tools and resources that help to bridge that spatial capability gap can have useful application in the educational realm. A free, map-based data discovery and visualisation tool developed with NSF funding at Lamont-Doherty Earth Observatory caters to students and teachers alike by providing a variety of data display and manipulation techniques that enhance geospatial awareness. Called GeoMapApp (http://www.geomapapp.org), the tool provides access to hundreds of built-in authentic geoscience data sets. Examples include earthquake and volcano data, geological maps, lithospheric plate boundary information, geochemical, oceanographic, and environmental data. Barriers to entry are lowered through easy installation, seamless integration of research-grade data sets, intuitive menus, and project-saving continuity. The default base map is a cutting-edge elevation model covering the oceans and land. Dynamic contouring, artificial illumination, 3-D visualisations, data point manipulations, cross-sectional profiles, and other display techniques help students grasp the content and geospatial context of data. Data sets can also be layered for easier comparison. Students may import their own data sets in Excel, ASCII, shapefile, and gridded format, and they can gain a sense of ownership by being able to tailor their data explorations and save their own projects. GeoMapApp is adaptable to a range of learning environments from lab sessions, group projects, and homework assignments to in-class pop-ups. A new Save Session

  14. Visualization and quantification of APP intracellular domain-mediated nuclear signaling by bimolecular fluorescence complementation.

    Directory of Open Access Journals (Sweden)

    Florian Riese

    Full Text Available BACKGROUND: The amyloid precursor protein (APP intracellular domain (AICD is released from full-length APP upon sequential cleavage by either α- or β-secretase followed by γ-secretase. Together with the adaptor protein Fe65 and the histone acetyltransferase Tip60, AICD forms nuclear multiprotein complexes (AFT complexes that function in transcriptional regulation. OBJECTIVE: To develop a medium-throughput machine-based assay for visualization and quantification of AFT complex formation in cultured cells. METHODS: We used cotransfection of bimolecular fluorescence complementation (BiFC fusion constructs of APP and Tip60 for analysis of subcellular localization by confocal microscopy and quantification by flow cytometry (FC. RESULTS: Our novel BiFC-constructs show a nuclear localization of AFT complexes that is identical to conventional fluorescence-tagged constructs. Production of the BiFC signal is dependent on the adaptor protein Fe65 resulting in fluorescence complementation only after Fe65-mediated nuclear translocation of AICD and interaction with Tip60. We applied the AFT-BiFC system to show that the Swedish APP familial Alzheimer's disease mutation increases AFT complex formation, consistent with the notion that AICD mediated nuclear signaling mainly occurs following APP processing through the amyloidogenic β-secretase pathway. Next, we studied the impact of posttranslational modifications of AICD on AFT complex formation. Mutation of tyrosine 682 in the YENPTY motif of AICD to phenylalanine prevents phosphorylation resulting in increased nuclear AFT-BiFC signals. This is consistent with the negative impact of tyrosine phosphorylation on Fe65 binding to AICD. Finally, we studied the effect of oxidative stress. Our data shows that oxidative stress, at a level that also causes cell death, leads to a reduction in AFT-BiFC signals. CONCLUSION: We established a new method for visualization and FC quantification of the interaction between

  15. Brassinosteroids Are Master Regulators of Gibberellin Biosynthesis in Arabidopsis

    Science.gov (United States)

    Unterholzner, Simon J.; Rozhon, Wilfried; Papacek, Michael; Ciomas, Jennifer; Lange, Theo; Kugler, Karl G.; Mayer, Klaus F.; Sieberer, Tobias; Poppenberger, Brigitte

    2015-01-01

    Plant growth and development are highly regulated processes that are coordinated by hormones including the brassinosteroids (BRs), a group of steroids with structural similarity to steroid hormones of mammals. Although it is well understood how BRs are produced and how their signals are transduced, BR targets, which directly confer the hormone’s growth-promoting effects, have remained largely elusive. Here, we show that BRs regulate the biosynthesis of gibberellins (GAs), another class of growth-promoting hormones, in Arabidopsis thaliana. We reveal that Arabidopsis mutants deficient in BR signaling are severely impaired in the production of bioactive GA, which is correlated with defective GA biosynthetic gene expression. Expression of the key GA biosynthesis gene GA20ox1 in the BR signaling mutant bri1-301 rescues many of its developmental defects. We provide evidence that supports a model in which the BR-regulated transcription factor BES1 binds to a regulatory element in promoters of GA biosynthesis genes in a BR-induced manner to control their expression. In summary, our study underscores a role of BRs as master regulators of GA biosynthesis and shows that this function is of major relevance for the growth and development of vascular plants. PMID:26243314

  16. Cholesterol biosynthesis and homeostasis in regulation of the cell cycle.

    Directory of Open Access Journals (Sweden)

    Pushpendra Singh

    Full Text Available The cell cycle is a ubiquitous, multi-step process that is essential for growth and proliferation of cells. The role of membrane lipids in cell cycle regulation is not explored well, although a large number of cytoplasmic and nuclear regulators have been identified. We focus in this work on the role of membrane cholesterol in cell cycle regulation. In particular, we have explored the stringency of the requirement of cholesterol in the regulation of cell cycle progression. For this purpose, we utilized distal and proximal inhibitors of cholesterol biosynthesis, and monitored their effect on cell cycle progression. We show that cholesterol content increases in S phase and inhibition of cholesterol biosynthesis results in cell cycle arrest in G1 phase under certain conditions. Interestingly, G1 arrest mediated by cholesterol biosynthesis inhibitors could be reversed upon metabolic replenishment of cholesterol. Importantly, our results show that the requirement of cholesterol for G1 to S transition is absolute, and even immediate biosynthetic precursors of cholesterol, differing with cholesterol merely in a double bond, could not replace cholesterol for reversing the cell cycle arrest. These results are useful in the context of diseases, such as cancer and Alzheimer's disease, that are associated with impaired cholesterol biosynthesis and homeostasis.

  17. NOAA Climate Data Record (CDR) of AVHRR Polar Pathfinder (APP) Cryosphere

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This NOAA Climate Data Record (CDR) contains the AVHRR Polar Pathfinder (APP) product. APP is a fundamental CDR comprised of calibrated and navigated AVHRR channel...

  18. How to start a home-based mobile app developer business

    CERN Document Server

    Brooks, Chad

    2014-01-01

    With the app market exploding, app designers will need a solid how-to guide to help them start their home-based business. This book will guide the reader through all the steps from design to marketing.

  19. The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells

    Institute of Scientific and Technical Information of China (English)

    SHENG BaiYang; NIU Ying; ZHOU Hui; YAN JiaXin; ZHAO NanMing; ZHANG XiuFang; GONG YanDao

    2009-01-01

    The amyloid precursor protein (APP) is recognized as the source of Aβ, which plays an important role in Alzheimer's disease. However, the biological function of APP is obscure. Previous studies showed that mitochondria could be a target of APP. In this work, APP knockout mouse embryo fibroblast (MEF) cells were used to test if APP plays any role in maintaining the mitochondrial function. As the result, APP knockout MEF cells (APP-/- cells) showed the abnormal mitochondrial function, including slower cell proliferation, lower mitochondrial membrane potential, lower intracellular ROS, higher mitochon-drial membrane fluidity and lower cytochrome c oxidase activity than their wild-type counterparts. However, no change was found in the amount of mitochondria in MEF APP-/- cells.

  20. Expert Involvement and Adherence to Medical Evidence in Medical Mobile Phone Apps

    DEFF Research Database (Denmark)

    Subhi, Yousif; Bube, Sarah Hjartbro; Rolskov Bojsen, Signe

    2015-01-01

    BACKGROUND: Both clinicians and patients use medical mobile phone apps. Anyone can publish medical apps, which leads to contents with variable quality that may have a serious impact on human lives. We herein provide an overview of the prevalence of expert involvement in app development and whether...... or not app contents adhere to current medical evidence. OBJECTIVE: To systematically review studies evaluating expert involvement or adherence of app content to medical evidence in medical mobile phone apps. METHODS: We systematically searched 3 databases (PubMed, The Cochrane Library, and EMBASE......), and included studies evaluating expert involvement or adherence of app content to medical evidence in medical mobile phone apps. Two authors performed data extraction independently. Qualitative analysis of the included studies was performed. RESULTS: Based on inclusion criteria, 52 studies were included...

  1. 76 FR 50481 - Announcement of Requirements and Registration for “Lifeline Facebook App Challenge”; Correction

    Science.gov (United States)

    2011-08-15

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HEALTH AND HUMAN SERVICES Announcement of Requirements and Registration for ``Lifeline Facebook App Challenge... Facebook App Challenge''. DATES: This correction is effective August 15, 2011. FOR FURTHER...

  2. Tell me your apps and I will tell you your mood: Correlation of apps usage with Bipolar Disorder State

    DEFF Research Database (Denmark)

    Alvarez-Lozano, Jorge; Frost, Mads; Osmani, Venet

    2014-01-01

    be captured through the analysis of smartphone usage. We have analysed changes in smartphone usage, specifically app usage and how these changes correlate with the self-reported patient state. We also used psychiatric evaluation scores provided by the clinic to understand correlation of the patient smartphone...... behaviour before the psychiatric evaluation and after the psychiatric evaluation. The results show that patients have strong correlation of patterns of app usage with different aspects of their self-reported state including mood, sleep and irritability. While, on the other hand, the patients’ application...... usage shows discernable changes in the period before and after psychiatric evaluation....

  3. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.

    Science.gov (United States)

    Li, Song; Hou, Huayan; Mori, Takashi; Sawmiller, Darrell; Smith, Adam; Tian, Jun; Wang, Yanjiang; Giunta, Brian; Sanberg, Paul R; Zhang, Sheqing; Tan, Jun

    2015-06-19

    BACE1 initiates amyloid-β (Aβ) generation and the resultant cerebral amyloidosis, as a characteristic of Alzheimer's disease (AD). Thus, inhibition of BACE1 has been the focus of a large body of research. The most recent clinical trials highlight the difficulty involved in this type of anti-AD therapy as evidenced by side effects likely due to the ubiquitous nature of BACE1, which cleaves multiple substrates. The human Swedish mutant form of amyloid protein precursor (APPswe) has been shown to possess a higher affinity for BACE1 compared to wild-type APP (APPwt). We pursued a new approach wherein harnessing this greater affinity to modulate BACE1 APP processing activity. We found that one peptide derived from APPswe, containing the β-cleavage site, strongly inhibits BACE1 activity and thereby reduces Aβ production. This peptide, termed APPswe BACE1 binding site peptide (APPsweBBP), was further conjugated to the fusion domain of the HIV-1 Tat protein (TAT) at the C-terminus to facilitate its biomembrane-penetrating activity. APPwt and APPswe over-expressing CHO cells treated with this TAT-conjugated peptide resulted in a marked reduction of Aβ and a significant increase of soluble APPα. Intraperitoneal administration of this peptide to 5XFAD mice markedly reduced β-amyloid deposits as well as improved hippocampal-dependent learning and memory.

  4. Mobile medical and health apps: state of the art, concerns, regulatory control and certification.

    Science.gov (United States)

    Boulos, Maged N Kamel; Brewer, Ann C; Karimkhani, Chante; Buller, David B; Dellavalle, Robert P

    2014-01-01

    This paper examines the state of the art in mobile clinical and health-related apps. A 2012 estimate puts the number of health-related apps at no fewer than 40,000, as healthcare professionals and consumers continue to express concerns about the quality of many apps, calling for some form of app regulatory control or certification to be put in place. We describe the range of apps on offer as of 2013, and then present a brief survey of evaluation studies of medical and health-related apps that have been conducted to date, covering a range of clinical disciplines and topics. Our survey includes studies that highlighted risks, negative issues and worrying deficiencies in existing apps. We discuss the concept of 'apps as a medical device' and the relevant regulatory controls that apply in USA and Europe, offering examples of apps that have been formally approved using these mechanisms. We describe the online Health Apps Library run by the National Health Service in England and the calls for a vetted medical and health app store. We discuss the ingredients for successful apps beyond the rather narrow definition of 'apps as a medical device'. These ingredients cover app content quality, usability, the need to match apps to consumers' general and health literacy levels, device connectivity standards (for apps that connect to glucometers, blood pressure monitors, etc.), as well as app security and user privacy. 'Happtique Health App Certification Program' (HACP), a voluntary app certification scheme, successfully captures most of these desiderata, but is solely focused on apps targeting the US market. HACP, while very welcome, is in ways reminiscent of the early days of the Web, when many "similar" quality benchmarking tools and codes of conduct for information publishers were proposed to appraise and rate online medical and health information. It is probably impossible to rate and police every app on offer today, much like in those early days of the Web, when people

  5. Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models

    OpenAIRE

    Smith, Karen D.B.; Erica Peethumnongsin; Han Lin; Hui Zheng; Pautler, Robia G.

    2010-01-01

    Amyloid precursor protein (APP) is implicated in axonal elongation, synaptic plasticity, and axonal transport. However, the role of APP on axonal transport in conjunction with the microtubule associated protein tau continues to be debated. Here we measured in vivo axonal transport in APP knockout mice with Manganese Enhanced MRI (MEMRI) to determine whether APP is necessary for maintaining normal axonal transport. We also tested how overexpression and mutations of tau affect axonal transport ...

  6. Making DidFail Succeed: Enhancing the CERT Static Taint Analyzer for Android App Sets

    Science.gov (United States)

    analyzer for sets of Android apps . In addition to improving the analyzer itself, the enhancements include a new testing framework new test apps , and test...use the most current version of FlowDroid and Soot, increasing its success rate from 18% to 68% on our test set of real-world apps . Analytical...features were added for more types of components and shared static fields and new apps developed to test these features. The improved DidFail analyzer and

  7. Learning by Doing: How to Develop a Cross-Platform Web App

    Science.gov (United States)

    Huynh, Minh; Ghimire, Prashant

    2015-01-01

    As mobile devices become prevalent, there is always a need for apps. How hard is it to develop an app, especially a cross-platform app? The paper shares an experience in a project that involved the development of a student services web app that can be run on cross-platform mobile devices. The paper first describes the background of the project,…

  8. Safe Sex Messages Within Dating and Entertainment Smartphone Apps: A Review

    OpenAIRE

    Huang, Evelyn Tzu-Yen; Williams, Henrietta; Hocking, Jane S; Lim, Megan SC

    2016-01-01

    Background Smartphone apps provide a new platform for entertainment, information distribution, and health promotion activities, as well as for dating and casual sexual encounters. Previous research has shown high acceptability of sexual health interventions via smartphone apps; however, sexual health promotion apps were infrequently downloaded and underused. Integrating sexual health promotion into established apps might be a more effective method. Objective The objective of our study was to ...

  9. Behavioral Functionality of Mobile Apps in Health Interventions: A Systematic Review of the Literature

    OpenAIRE

    Payne, Hannah E; Lister, Cameron; West, Josh; Bernhardt, Jay M.

    2015-01-01

    Background Several thousand mobile phone apps are available to download to mobile phones for health and fitness. Mobile phones may provide a unique means of administering health interventions to populations. Objective The purpose of this systematic review was to systematically search and describe the literature on mobile apps used in health behavior interventions, describe the behavioral features and focus of health apps, and to evaluate the potential of apps to disseminate health behavior in...

  10. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

    OpenAIRE

    Katherine R Sadleir; Eimer, William A; Cole, Sarah L.; Vassar, Robert

    2015-01-01

    Background The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer’s disease (AD). Reducing BACE1 activity is an attractive therapeutic approach to AD, but complete inhibition of BACE1 could have mechanism-based side-effects as BACE1−/− mice show deficits in axon guidance, myelination, memory, and other neurological processes. Since BACE1+/− mice appear normal there is interest in determining whether 50% reduction in...

  11. Designing the online oral language learning environment SpeakApps

    NARCIS (Netherlands)

    Nic Giolla Mhichíl, Mairéad; Appel, Christine; Ó Ciardubháin, Colm; Jager, Sake; Prizel-Kania, Adriana

    2015-01-01

    Purpose – The purpose of this paper is to report on SpeakApps, a major collaborative computer-assisted language learning project, developed based on an open source techno-pedagogical solution to facilitate online oral language production and interaction. Design/methodology/approach – A mixed method

  12. Portable Desktop Apps with GitHub Electron

    CERN Document Server

    CERN. Geneva

    2016-01-01

    Wouldn't it be nice if you could develop applications that work everywhere, regardless of Operating System or Platform? Even better, what if you could employ the same front-end technologies you use for your web/mobile apps? Meet GitHub Electron.

  13. Developing mobile educational apps: development strategies, tools and business models

    Directory of Open Access Journals (Sweden)

    Serena Pastore

    Full Text Available The mobile world is a growing and evolving market in all its aspects from hardware, networks, operating systems and applications. Mobile applications or apps are becoming the new frontier of software development, since actual digital users use mobile devi ...

  14. WhatsApp Messaging: Achievements and Success in Academia

    Science.gov (United States)

    Nitza, Davidivitch; Roman, Yavich

    2016-01-01

    In recent years, there has been a significant rise in the use of technological means in general and in academic teaching in particular. Many programs have been developed that include computer-assisted teaching, as well as online courses at educational institutions. The current study focuses on WhatsApp messaging and its use in academia. Studies…

  15. Shaking up Expectations: The OCLS Shake It! App

    Science.gov (United States)

    Shivers, Cassandra

    2012-01-01

    The author, a digital access architect in the information systems department of the Orange County Library System in Florida, was given the challenge of creating a library mobile app around the 2009 holiday season. At that time, Sheri Chambers, digital content manager in the information systems department, and Debbie Moss, assistant director of the…

  16. Mobiele apparaten en apps als versnellers van Open Educational Resources

    NARCIS (Netherlands)

    De Vries, Fred; Thuss, Frank

    2013-01-01

    De Vries, F., & Thuss, F. (2013). Mobiele apparaten en apps als versnellers van Open Educational Resources? In R. Jacobi, H. Jelgerhuis, & N. van der Woert (Eds.), Trendrapport Open Educational Resources 2013 (pp. 51-54). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources S

  17. Helft vleesvarkens vaccineren tegen App. vermindert pleuritis niet

    NARCIS (Netherlands)

    Peet-Schwering, van der C.M.C.; Stockhofe-Zurwieden, N.; Cruijsen, T.; Leengoed, van L.A.M.G.; Raymakers, R.

    2006-01-01

    Door de helft van de varkens op een leeftijd van 6, 10 en 14 weken te vaccineren tegen App. neemt het percentage vleesvarkens met pleuritis op moment van slachten af van 41 naar 35 procent. Dit blijkt uit onderzoek van de PVE, dat in 2005 is uitgevoerd op Praktijkcentrum Sterksel

  18. Apps for Physical Education: Teacher Tested, Kid Approved!

    Science.gov (United States)

    Phillips, Amber; Rodenbeck, Myshel; Clegg, Bethany

    2014-01-01

    Physical education teachers have been encouraged to use technology in their classes to enhance student motivation and learning. The purpose of this article is to share iOS applications (apps) that K-12 physical education teachers and students have found useful.

  19. Exploring Mobile Apps for English Language Teaching and Learning

    Science.gov (United States)

    Zou, Bin; Li, Jiaying

    2015-01-01

    Many recent studies have shown that mobile learning can provide potential possibilities for foreign language learners to practice language skills on their smart mobile phones and tablet PCs (e.g. Chang & Hsu, 2011; Egbert, Akasha, Huff, & Lee, 2011; Hoven & Palalas, 2011; Stockwell, 2010). A number of apps have been created and used…

  20. The APP A673T frequency differs between Nordic countries

    DEFF Research Database (Denmark)

    Mengel-From, Jonas; Jeune, Bernard; Pentti, Tienari;

    2015-01-01

    A coding gene variant A673T (rs63750847) in the APP gene has recently been recognized as a protective variant of late-onset Alzheimer's Disease in a large Icelandic population and has been observed recurrently in populations from Nordic countries. The variant also was related to longevity...

  1. Effects of Using an Ipod App to Manage Recreation Tasks

    Science.gov (United States)

    Uphold, Nicole M.; Douglas, Karen H.; Loseke, Dannell L.

    2016-01-01

    A withdrawal design study evaluated the effectiveness of using constant time delay to teach six adults with a developmental disability to program and use an iPod touch® as an electronic photographic activity schedule (ePAS). The ePAS, created with the First Then Visual Schedule app, consisted of photographs of different exercises to complete…

  2. CERN@school: a new app displays natural radiation data

    CERN Multimedia

    Julio Rosenfeld

    2012-01-01

    A student from the Simon Langton Grammar School for Boys in Kent (UK) has developed an app that displays data recorded by Medipix chips. Created for Android-based devices, the app is a new way for students to visualize the natural radiation in their local area.   James Hurst shows off the Medipix chips at his school's stand at the UK's Royal Society Summer Science Exhibition. James Hurst, 17, developed the app in the framework of the CERN@school project that Becky Parker, a former participant in CERN’s High School Teachers (HST) programme, set up in 2008. “The app is able to display pre-recorded data in both graphic and numeric formats,” explains James. “I am already envisaging further developments, which might include producing the iOS version and eventually a live data-taking system.” CLEAR (Comprehensive Langton Evaluation and Analysis of Radiation), as it is named, will soon be available free from the Android Market toget...

  3. Apps. Accessibility and Usability by People with Visual Disabilities

    Science.gov (United States)

    Olmedo-Moreno, Eva María; López-Delgado, Adrian

    2015-01-01

    The increasing use of ICT devices, such as smartphones and tablets, needs development of properly software or apps to facilitate socio-educative life of citizens in smart cities: Adaptive educational resources, leisure and entertainment facilities or mobile payment services, among others. Undoubtedly, all that is opening a new age with more…

  4. Mobile Devices and Apps as Accelerators for OER

    NARCIS (Netherlands)

    De Vries, Fred; Thuss, Frank

    2013-01-01

    De Vries, F., & Thuss, F. (2013). Mobile Devices and Apps as accelerators for OER. In R. Jacobi, H. Jelgerhuis, & N. Van der Woert (Eds.), Trendreport Open Educational Resources 2013 (pp. 49-52). Utrecht: SURF Foundation - Special Interest Group Open Educational Resources SURF.

  5. Glucosinolate biosynthesis in Eruca sativa.

    Science.gov (United States)

    Katsarou, Dimitra; Omirou, Michalis; Liadaki, Kalliopi; Tsikou, Daniela; Delis, Costas; Garagounis, Constantine; Krokida, Afrodite; Zambounis, Antonis; Papadopoulou, Kalliope K

    2016-12-01

    Glucosinolates (GSLs) are a highly important group of secondary metabolites in the Caparalles order, both due to their significance in plant-biome interactions and to their chemoprotective properties. This study identified genes involved in all steps of aliphatic and indolic GSL biosynthesis in Eruca sativa, a cultivated plant closely related to Arabidopsis thaliana with agronomic and nutritional value. The impact of nitrogen (N) and sulfur (S) availability on GSL biosynthetic pathways at a transcriptional level, and on the final GSL content of plant leaf and root tissues, was investigated. N and S supply had a significant and interactive effect on the GSL content of leaves, in a structure-specific and tissue-dependent manner; the metabolites levels were significantly correlated with the relative expression of the genes involved in their biosynthesis. A more complex effect was observed in roots, where aliphatic and indolic GSLs and related biosynthetic genes responded differently to the various nutritional treatments suggesting that nitrogen and sulfur availability are important factors that control plant GSL content at a transcriptional level. The biological activity of extracts derived from these plants grown under the specific nutritional schemes was examined. N and S availability were found to significantly affect the cytotoxicity of E. sativa extracts on human cancer cells, supporting the notion that carefully designed nutritional schemes can promote the accumulation of chemoprotective substances in edible plants.

  6. Using GeoMapApp to access and interpret high-resolution bathymetric data collected with deep submergence vehicles

    Science.gov (United States)

    Ferrini, V.; Carbotte, S. M.; Ryan, W. B.; O'hara, S. H.; Bonczkowski, J.; Arko, R. A.

    2011-12-01

    Bathymetric data products generated with deep submergence technology can be of meter to sub-meter resolution, providing an unprecedented view of seafloor features. Data at this resolution provide near photo-quality information that can be used to not only quantify morphologic features and create geologic maps, but can also be used to develop and refine remote seafloor characterization techniques. Nesting these data within regional lower resolution data, and supplementing them with ground-truth photos and observations from seafloor samples is often the key to understanding the geologic features revealed in bathymetric data. Through the efforts of the Ridge 2000 Program and the Ridge 2000 Data Portal, many of these data have been acquired, assembled, spatially co-registered, and made directly accessible through a variety of programmatic interfaces. The Data Portal provides direct downloads of raw and processed data files with full attribution to contributing scientists and links to publications. In addition, GeoMapApp, a free Java-based visualization and analysis tool, provides quantitative access to several high-resolution bathymetry data sets within the context of important complementary data. The default basemap in GeoMapApp is the Global Multi-Resolution Topography (GMRT) Synthesis, which includes ship-based bathymetry data from over 500 research cruises as well as contributed regional grids, providing resolution of 100 m or better in many areas. GeoMapApp provides quantitative access to the GMRT, which can be used to understand the regional context of localized high-resolution bathymetry data. Other related data directly accessible through GeoMapApp include sidescan data, sample positions and descriptions, and bottom photos acquired with National Deep Submergence Facility assets and the WHOI TowCam System. Quantitative tools for interrogating and interpreting the data (e.g. profiling, changing sun-illumination and color scale) are provided within GeoMapApp to

  7. E-Books and E-Book Apps: Considerations for Beginning Readers

    Science.gov (United States)

    Bates, Celeste C.; Klein, Adria; Schubert, Barbara; McGee, Lea; Anderson, Nancy; Dorn, Linda; McClure, Erin; Ross, Rachael Huber

    2017-01-01

    This article highlights considerations for teachers when selecting and using e-books and e-book applications (apps) with beginning readers during guided and independent reading. A framework for examining e-books and e-book apps is suggested, and several apps and related digital features are described. The article also includes an overview of…

  8. A Detailed Rubric for Assessing the Quality of Teacher Resource Apps

    Science.gov (United States)

    Cherner, Todd; Lee, Cheng-Yuan; Fegely, Alex; Santaniello, Lauren

    2016-01-01

    Since the advent of the iPhone and rise of mobile technologies, educational apps represent one of the fastest growing markets, and both the mobile technology and educational app markets are predicted to continue experiencing growth into the foreseeable future. The irony, however, is that even with a booming market for educational apps, very little…

  9. On the signaling mechanism and the absence of photoreversibility in the AppA BLUF domain

    NARCIS (Netherlands)

    Toh, K.C.; van Stokkum, I.H.M.; Hendriks, J.; Alexandre, M.T.A.; Arents, J.C.; Avila Perez, M.; van Grondelle, R.; Hellingwerf, K.J.; Kennis, J.T.M.

    2008-01-01

    The flavoprotein AppA from Rhodobacter sphaeroides contains an N-terminal, FAD-binding BLUF photoreceptor domain. Upon illumination, the AppA BLUF domain forms a signaling state that is characterized by red-shifted absorbance by 10 nm, a state known as AppA(RED). We have applied ultrafast spectrosco

  10. 77 FR 72864 - Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge

    Science.gov (United States)

    2012-12-06

    ... HUMAN SERVICES Announcement of Requirements and Registration for healthfinder.gov Mobile App Challenge... Disease Prevention and Health Promotion (ODPHP) is launching a healthfinder.gov Mobile App Challenge to promote the development of a mobile app that will facilitate the customized use of prevention and...

  11. Conducting Cognitive Exercises for Early Dementia with the Use of Apps on iPads

    Science.gov (United States)

    Kong, Anthony Pak-Hin

    2015-01-01

    A list of iTunes apps was compiled for usage with early stage or mild dementia participants. The method in choosing these apps and determining salient features of the most successful apps was reported. The results will advance the knowledge base on innovative use of smart technology in clinical settings.

  12. A Student's Guide to Critical Reading Using APPS

    Science.gov (United States)

    Rautman, Alison E.

    2014-01-01

    The concept of smart phone apps forms a mnemonic device and checklist for students who are learning critical thinking and reading skills. "Use your apps" reminds students to consider the importance of Author, Audience, Assumptions, Point of View, Perspective, and Scale when reading any text. "APPS" also lends itself to class…

  13. Choosing iPad Apps with a Purpose: Aligning Skills and Standards

    Science.gov (United States)

    Powell, Selma

    2014-01-01

    With the number of apps available today, browsing the iTunes store can become overwhelming for any teacher. A teacher can quickly try free apps, but to have full access, cost is often involved. Purchasing numerous apps can be expensive and time consuming and, most important, may not produce an outcome of acquiring tools that are well aligned with…

  14. Apps for immunization: Leveraging mobile devices to place the individual at the center of care.

    Science.gov (United States)

    Wilson, Kumanan; Atkinson, Katherine M; Westeinde, Jacqueline

    2015-01-01

    Mobile technology and applications (apps) have disrupted several industries including healthcare. The advantage of apps, being personally focused and permitting bidirectional communication, make them well suited to address many immunization challenges. As of April 25, 2015 searching the Android app store with the words 'immunize app' and 'immunization app' in Canada yielded 225 apps. On the Apple App Store a similar search produced 98 results. These include apps that provide immunization related information, permit vaccine tracking both for individuals and for animals, assist with the creation of customized schedules and identification of vaccine clinics and serve as sources of education. The diverse functionality of mobile apps creates the potential for transformation of immunization practice both at a personal level and a system level. For individuals, mobile apps offer the opportunity for better record keeping, assistance with the logistics of vaccination, and novel ways of communicating with and receiving information from public health officials. For the system, mobile apps offer the potential to improve the quality of information residing in immunization information systems and program evaluation, facilitate harmonization of immunization information between individuals, health care providers and public health as well as reduce vaccine hesitancy. As mobile technology continues to rapidly evolve there will emerge new ways in which apps can enhance immunization practice.

  15. Variability Handling for Mobile Banking Apps on iOS and Android

    DEFF Research Database (Denmark)

    Jørgensen, Jens Bæk; Knudsen, Bjarne; Sloth, Lennert

    2016-01-01

    During the last four years, Mjølner Informatics has developed mobile banking apps for 11 different Danish banks on the two major platforms iOS and Android, in total 22 apps. We make two contributions with this industrial practice paper. In the first place, we describe the development of these apps...

  16. Beyond WhatsApp: Older people and smartphones

    Directory of Open Access Journals (Sweden)

    Andrea Rosales

    2016-06-01

    Full Text Available This paper analyzes how older people, living in Spain, use smartphones and smartphone applications. Using a mixed methods approach, we compare quantitative results obtained by tracking mobile app usage amongst different generational samples with qualitative, focus-group discussions with active smartphone users. A sample of Spanish smartphone users were tracked during one month in the winter of 2014 (238 individuals, aged 20 to 76 years-old. This was followed by three focus group sessions conducted in the spring of 2015, with 24 individuals aged 55 to 81. As we learned, WhatsApp is currently the most popular application used by people of all ages, including older adults. Smartphones increasingly are playing a central role in the life of older participants, although the frequency of app access is negatively correlated with age. On the other hand, as our data indicates, older adults also use a number of different types of apps that are distinct from that of younger users. Older participants access personal information manager apps (calendar, address book and notes more often than other age groups. And comparatively, older participants use the smartphone less often in stable locations (home, office, relatives’ home with Wifi than somewhere else and with mobile data. As we argue, differences in age seem to reflect the evolution in personal interests and communication patterns that change as we grow older. Our study captures new trends in smartphone usage amongst this cohort. It also indicates how a combination of methods may help to assess the validity of the log and qualitative data. We highlight the relevance of conducting careful generational studies in smartphone use and some of the potentials and limitations of making predictive studies of ICT use as we change throughout the life course. Finally, we assert the value of the inclusion of older representatives within research, which ultimately may influence public decisions and the design of new

  17. Using Smartphone Apps in STD Interviews to Find Sexual Partners

    Science.gov (United States)

    Pennise, Melissa; Herpin, Kate; Owens, John; Bedard, Brenden A.; Weimer, Anita C.; Kennedy, Byron S.; Younge, Mary

    2015-01-01

    Objectives Smartphone applications (apps) are increasingly used to facilitate casual sexual relationships, increasing the risk of sexually transmitted diseases (STDs). In STD investigations, traditional contact elicitation methods can be enhanced with smartphone technology during field interviews. Methods In 2013, the Monroe County Department of Public Health conducted a large, multi-infection STD investigation among men who have sex with men (MSM) using both index case and cluster interviews. When patients indicated meeting sexual partners online, disease intervention specialists (DISs) had access to smartphone apps and were able to elicit partners through access to inboxes and profiles where traditional contact information was lacking. Social network mapping was used to display the extent of the investigation and the impact of access to smartphones on the investigation. Results A total of 14 index patient interviews and two cluster interviews were conducted; 97 individuals were identified among 117 sexual dyads. On average, eight partners were elicited per interview (range: 1–31). The seven individuals who used apps to find partners had an average of three Internet partners (range: 1–5). Thirty-six individuals either had a new STD (n=7) or were previously known to be HIV-positive (n=29). Of the 117 sexual dyads, 21 (18%) originated either online (n=8) or with a smartphone app (n=13). Of those originating online or with a smartphone app, six (29%) partners were located using the smartphone and two (10%) were notified of their exposure via a website. Three of the new STD/HIV cases were among partners who met online. Conclusion Smartphone technology used by DISs in the field improved contact elicitation and resulted in successful partner notification and case finding. PMID:25931628

  18. EXPRESSED PROTEIN LIGATION. A NEW TOOL FOR THE BIOSYNTHESIS OF CYCLIC POLYPEPTIDES

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, R; Camarero, J A

    2004-11-11

    The present paper reviews the use of expressed protein ligation for the biosynthesis of backbone cyclic polypeptides. This general method allows the in vivo and in vitro biosynthesis of cyclic polypeptides using recombinant DNA expression techniques. Biosynthetic access to backbone cyclic peptides opens the possibility to generate cell-based combinatorial libraries that can be screened inside living cells for their ability to attenuate or inhibit cellular processes.

  19. How to Find Good Apps: An Evaluation Rubric for Instructional Apps for Teaching Students with Learning Disabilities

    Science.gov (United States)

    Ok, Min Wook; Kim, Min Kyung; Kang, Eun Young; Bryant, Brian R.

    2016-01-01

    Computers can be an effective teaching method for students with learning disabilities (LD). The use of mobile devices as education tools for students with disabilities has received considerable attention in special education recently. Parents, teachers, and professionals look for effective applications (i.e., apps) that meet the needs of their…

  20. Diabetes Applications for Arabic Speakers: A Critical Review of Available Apps for Android and iOS Operated Smartphones.

    Science.gov (United States)

    Alhuwail, Dari

    2016-01-01

    Today, 415 million adults have diabetes; more than 35 million of diabetic adults live in the Middle East and North Africa region. Smartphone penetration in the region is high and applications, or apps, for diabetics have shown promising results in recent years. This study took place between September and December 2015 and reviewed all currently available smartphone diabetes apps for Arabic speakers in both the Apple App and Google Play stores. There were only few diabetes apps for Arabic speakers; only eighteen apps were discovered and considered for this study. Most apps were informational. Only three apps offered utilities such as glucose reading conversion. The apps had issues related to information quality and adherence to latest evidence-based medical advice. There is a need for more evidence-based Arabic diabetes apps with improved functionality. Future research of Arabic diabetes apps should also focus on the involvement and engagement of the patients in the design of these apps.

  1. Biosynthesis of active pharmaceuticals: β-lactam biosynthesis in filamentous fungi.

    Science.gov (United States)

    Van Den Berg, Marco; Gidijala, Loknath; Kiela, Jan; Bovenberg, Roel; Vander Keli, Ida

    2010-01-01

    β-lactam antibiotics (e.g. penicillins, cephalosporins) are of major clinical importance and contribute to over 40% of the total antibiotic market. These compounds are produced as secondary metabolites by certain actinomycetes and filamentous fungi (e.g. Penicillium, Aspergillus and Acremonium species). The industrial producer of penicillin is the fungus Penicillium chrysogenum. The enzymes of the penicillin biosynthetic pathway are well characterized and most of them are encoded by genes that are organized in a cluster in the genome. Remarkably, the penicillin biosynthetic pathway is compartmentalized: the initial steps of penicillin biosynthesis are catalyzed by cytosolic enzymes, whereas the two final steps involve peroxisomal enzymes. Here, we describe the biochemical properties of the enzymes of β-lactam biosynthesis in P. chrysogenum and the role of peroxisomes in this process. An overview is given on strain improvement programs via classical mutagenesis and, more recently, genetic engineering, leading to more productive strains. Also, the potential of using heterologous hosts for the development of novel ß-lactam antibiotics and non-ribosomal peptide synthetase-based peptides is discussed.

  2. Instant Passbook app development for iOS how-to

    CERN Document Server

    Moon, Keith D

    2013-01-01

    Filled with practical, step-by-step instructions and clear explanations for the most important and useful tasks. A step-by-step guide, focusing on simple projects to help you create a Passbook app for iOS 6.Instant Passbook App Development for iOS 6 How-to is for registered Apple iOS developers, experienced in building an app using Objective-C and Xcode, looking to add Passbook functionality to their app. You will need to have an understanding of the JSON format, REST APIs, and a server-side language like Ruby. Familiarity with executing commands via the Terminal app is expected for the exerci

  3. An Investigation into the Use of Common Libraries in Android Apps

    OpenAIRE

    Li LI; Bissyandé, Tegawendé F.; Klein, Jacques; Le Traon, Yves

    2016-01-01

    The packaging model of Android apps requires the entire code necessary for the execution of an app to be shipped into one single apk file. Thus, an analysis of Android apps often visits code which is not part of the functionality delivered by the app. Such code is often contributed by the common libraries which are used pervasively by all apps. Unfortunately, Android analyses, e.g., for piggybacking detection and malware detection, can produce inaccurate results if they do not take into accou...

  4. Steroid biosynthesis in adipose tissue.

    Science.gov (United States)

    Li, Jiehan; Papadopoulos, Vassilios; Vihma, Veera

    2015-11-01

    Tissue-specific expression of steroidogenic enzymes allows the modulation of active steroid levels in a local manner. Thus, the measurement of local steroid concentrations, rather than the circulating levels, has been recognized as a more accurate indicator of the steroid action within a specific tissue. Adipose tissue, one of the largest endocrine tissues in the human body, has been established as an important site for steroid storage and metabolism. Locally produced steroids, through the enzymatic conversion from steroid precursors delivered to adipose tissue, have been proven to either functionally regulate adipose tissue metabolism, or quantitatively contribute to the whole body's steroid levels. Most recently, it has been suggested that adipose tissue may contain the steroidogenic machinery necessary for the initiation of steroid biosynthesis de novo from cholesterol. This review summarizes the evidence indicating the presence of the entire steroidogenic apparatus in adipose tissue and discusses the potential roles of local steroid products in modulating adipose tissue activity and other metabolic parameters.

  5. Acylphloroglucinol Biosynthesis in Strawberry Fruit.

    Science.gov (United States)

    Song, Chuankui; Ring, Ludwig; Hoffmann, Thomas; Huang, Fong-Chin; Slovin, Janet; Schwab, Wilfried

    2015-11-01

    Phenolics have health-promoting properties and are a major group of metabolites in fruit crops. Through reverse genetic analysis of the functions of four ripening-related genes in the octoploid strawberry (Fragaria × ananassa), we discovered four acylphloroglucinol (APG)-glucosides as native Fragaria spp. fruit metabolites whose levels were differently regulated in the transgenic fruits. The biosynthesis of the APG aglycones was investigated by examination of the enzymatic properties of three recombinant Fragaria vesca chalcone synthase (FvCHS) proteins. CHS is involved in anthocyanin biosynthesis during ripening. The F. vesca enzymes readily catalyzed the condensation of two intermediates in branched-chain amino acid metabolism, isovaleryl-Coenzyme A (CoA) and isobutyryl-CoA, with three molecules of malonyl-CoA to form phlorisovalerophenone and phlorisobutyrophenone, respectively, and formed naringenin chalcone when 4-coumaroyl-CoA was used as starter molecule. Isovaleryl-CoA was the preferred starter substrate of FvCHS2-1. Suppression of CHS activity in both transient and stable CHS-silenced fruit resulted in a substantial decrease of APG glucosides and anthocyanins and enhanced levels of volatiles derived from branched-chain amino acids. The proposed APG pathway was confirmed by feeding isotopically labeled amino acids. Thus, Fragaria spp. plants have the capacity to synthesize pharmaceutically important APGs using dual functional CHS/(phloriso)valerophenone synthases that are expressed during fruit ripening. Duplication and adaptive evolution of CHS is the most probable scenario and might be generally applicable to other plants. The results highlight that important promiscuous gene function may be missed when annotation relies solely on in silico analysis.

  6. Mobile App Design for Teaching and Learning: Educators’ Experiences in an Online Graduate Course

    Directory of Open Access Journals (Sweden)

    Yu-Chang Hsu

    2013-09-01

    Full Text Available This research explored how educators with limited programming experiences learned to design mobile apps through peer support and instructor guidance. Educators were positive about the sense of community in this online course. They also considered App Inventor a great web-based visual programming tool for developing useful and fully functioning mobile apps. They had great sense of empowerment through developing unique apps by using App Inventor. They felt their own design work and creative problem solving were inspired by the customized mobile apps shared by peers. The learning activities, including sharing customized apps, providing peer feedback, composing design proposals, and keeping design journals (blogging, complemented each other to support a positive sense of community and form a strong virtual community of learning mobile app design. This study helped reveal the educational value of mobile app design activities and the web-based visual programming tool, and the possibility of teaching/learning mobile app design online. The findings can also encourage educators to explore and experiment on the potential of incorporating these design learning activities in their respective settings, and to develop mobile apps for their diverse needs in teaching and learning.

  7. A content analysis of precede-proceed constructs in stress management mobile apps

    Science.gov (United States)

    Wilkinson, Jessica; West, Joshua H.; Bernhardt, Jay M.

    2016-01-01

    Background The emergence of Apple’s iPhone provides a platform for freelance developers to design third party apps, which greatly expands the functionality and utility of mobile devices for stress management. This study provides a basic overview of the stress management apps under the health and fitness category of the Apple App store and appraises each app’s potential for influencing behavior change. Methods Data for this study came from a content analysis of health and fitness app descriptions available in the App Store on iTunes. Trained research assistants used the Precede-Proceed Model (PPM) as a framework to guide the coding of paid stress management apps and to evaluate each app’s potential for effecting health behavior change. Results Most apps were rated as being plausible (96.9%) and intending to address stress management (98.5%), but only 63.3% were rated as recommendable to others for their use. Reinforcing apps were less common than predisposing and enabling apps. Less than one percent (0.39%) of apps included all three factors (predisposing, enabling and reinforcing). Conclusions Practitioners should be cautious when promoting the use of stress management apps, as most provide only health-related information (predisposing) or suggestions for enabling behavior, but almost none include all three theoretical factors recommended for behavior change. PMID:28293583

  8. APP-A Novel Player within the Presynaptic Active Zone Proteome.

    Science.gov (United States)

    Weingarten, Jens; Weingarten, Melanie; Wegner, Martin; Volknandt, Walter

    2017-01-01

    The amyloid precursor protein (APP) was discovered in the 1980s as the precursor protein of the amyloid A4 peptide. The amyloid A4 peptide, also known as A-beta (Aβ), is the main constituent of senile plaques implicated in Alzheimer's disease (AD). In association with the amyloid deposits, increasing impairments in learning and memory as well as the degeneration of neurons especially in the hippocampus formation are hallmarks of the pathogenesis of AD. Within the last decades much effort has been expended into understanding the pathogenesis of AD. However, little is known about the physiological role of APP within the central nervous system (CNS). Allocating APP to the proteome of the highly dynamic presynaptic active zone (PAZ) identified APP as a novel player within this neuronal communication and signaling network. The analysis of the hippocampal PAZ proteome derived from APP-mutant mice demonstrates that APP is tightly embedded in the underlying protein network. Strikingly, APP deletion accounts for major dysregulation within the PAZ proteome network. Ca(2+)-homeostasis, neurotransmitter release and mitochondrial function are affected and resemble the outcome during the pathogenesis of AD. The observed changes in protein abundance that occur in the absence of APP as well as in AD suggest that APP is a structural and functional regulator within the hippocampal PAZ proteome. Within this review article, we intend to introduce APP as an important player within the hippocampal PAZ proteome and to outline the impact of APP deletion on individual PAZ proteome subcommunities.

  9. Do Arabic weight-loss apps adhere to evidence-informed practices?

    Science.gov (United States)

    Alnasser, Aroub A; Amalraj, Raja E; Sathiaseelan, Arjuna; Al-Khalifa, Abdulrahman S; Marais, Debbi

    2016-09-01

    Mobile technology has been used successfully for promoting health and weight loss and for treating obesity. There is a high prevalence of smartphone and tablet users among the Saudi population. This study aimed to identify whether current Arabic weight-loss apps had features that adhered to evidence-informed practices. The six most relevant app stores were systematically searched using the Arabic words for weight and diet (n = 298). All apps that met the inclusion criteria (n = 65) were downloaded and examined for adherence to 13 evidence-informed practices. Latent class analysis identified two subgroups of apps: self-monitoring (15 % of apps) and advice-giving apps (85 %). The median number of evidence-informed practices was 1 (1, 2), with no apps having more than six and only nine apps including four to six. Meal planning was the most common feature (38 % of apps). These findings identify serious weaknesses in the currently available Arabic weight-loss apps. Thus, existing and future apps should include more features based on the best available evidence in the context of Arab culture.

  10. BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease

    Directory of Open Access Journals (Sweden)

    Minthon Lennart

    2010-09-01

    Full Text Available Abstract The BACE1 gene encodes the beta-site APP-cleaving enzyme 1 and has been associated with Alzheimer's disease (AD. BACE1 is the most important β-secretase responsible for the generation of Alzheimer-associated amyloid β-proteins (Aβ and may play a role in the amyloidogenic process in AD. We hypothesized that BACE1 gene variants might influence BACE1 activity or other markers for APP metabolism in the cerebrospinal fluid (CSF and thereby contribute to the development of AD. We genotyped a Swedish sample of 269 AD patients for the rs638405 single nucleotide polymorphism (SNP in the BACE1 gene and correlated genotype data to a broad range of amyloid-related biomarkers in CSF, including BACE1 activity, levels of Aβ40, Aβ42, α- and β-cleaved soluble APP (α-sAPP and β-sAPP, as well as markers for Alzheimer-type axonal degeneration, i.e., total-tau and phospho-tau181. Gene variants of BACE1 were neither associated with amyloid-related biomarkers, nor with markers for axonal degeneration in AD.

  11. Identification of Protein-Protein Interactions Involved in Pectin Biosynthesis in the golgi Apparatus

    DEFF Research Database (Denmark)

    Lund, Christian Have

    GALACTURONOSYLTRANSFERASE1 (GAUT1) and GAUT7 has beesn identified and is essential for pectin biosynthesis. Interestingly, GAUT1 has been shown to be proteolytic processed from its transmembrane anchor domain and its catalytic domain is retained by GAUT7, thus ensuring biosynthesis of HG in the Golgi apparatus. Many...... methods exist in identifying protein-protein interaction (PPI) but many of these are developed for other organisms than plants and are most applicable for PPI detection in other organelles than the Golgi apparatus where pectin biosynthesis occurs. In this work, different PPI detection methods are examined...... for their ability to detect PPI inside the Golgi lumen. The first method tested was the commercially available splitubiquitin system from Dualsystems Biotech AG. This was applied to test binary interactions between proteins involved in HG and Rhamnogalacturonan I (RG-I) biosynthesis (see Manuscript II...

  12. Current Status and Quality Assessment of Cardiovascular Diseases Related Smartphone Apps in China.

    Science.gov (United States)

    Xiao, Qian; Wang, Yanling; Sun, Liu; Lu, Sai; Wu, Ying

    2016-01-01

    To examine current status and quality of CVD related apps available for download in China, a total of 151 apps from the top popular six app stores were analyzed. Data analysis uncovered a range of issues including missing of key variables in the pre-formatted daily records, no platform for interaction with relevant healthcare professionals and undesirable user-interface design. More importantly, these apps had low levels of adherence to internationally recognized guidelines in CVD management. Overall quality score of these apps was below the average (8.08/20). This study identified areas for improvement concerning the existing CVD related apps. Information may guide the further advancement of CVD related apps and benefit CVD management in China.

  13. mHealth and mobile medical Apps: a framework to assess risk and promote safer use.

    Science.gov (United States)

    Lewis, Thomas Lorchan; Wyatt, Jeremy C

    2014-09-15

    The use of mobile medical apps by clinicians and others has grown considerably since the introduction of mobile phones. Medical apps offer clinicians the ability to access medical knowledge and patient data at the point of care, but several studies have highlighted apps that could compromise patient safety and are potentially dangerous. This article identifies a range of different kinds of risks that medical apps can contribute to and important contextual variables that can modify these risks. We have also developed a simple generic risk framework that app users, developers, and other stakeholders can use to assess the likely risks posed by a specific app in a specific context. This should help app commissioners, developers, and users to manage risks and improve patient safety.

  14. Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice.

    Science.gov (United States)

    Infante-Garcia, Carmen; Ramos-Rodriguez, Juan Jose; Delgado-Olmos, Irene; Gamero-Carrasco, Carlos; Fernandez-Ponce, Maria Teresa; Casas, Lourdes; Mantell, Casimiro; Garcia-Alloza, Monica

    2016-07-21

    Alzheimer's disease (AD) is the most common cause of dementia; however, available treatments have had limited success. Therefore AD patients are in tremendous need of new pharmacological approaches that may delay or slow the progression of the disease. In addition to the classical neuropathological features, immunological and inflammatory processes are also involved in AD pathogenesis. Naturally occurring compounds, such as Mangifera indica Linn (MGF) extracts have previously been shown to significantly reduce peripheral inflammatory processes. In order to explore the role of MGF in AD central pathology, we have orally treated APP/PS1 mice for 22 weeks. While MGF did not affect amyloid pathology, tau hyperphosphorylation was significantly reduced in the cortex and hippocampus. Also, inflammatory processes, measured by microglia and astrocyte burdens, were diminished in MGF-treated mice. Moreover, neuronal morphological alterations, such as abnormal neurite curvature and dystrophies, highly increased in APP/PS1 mice, were significantly ameliorated by long-term MGF treatment. Reduction of all these pathological features were accompanied by compelling improvements of episodic and spatial memory in APP/PS1 mice treated with MGF. Altogether our data suggest that MGF may provide a useful tool to target different aspects of AD pathology and could lead to more effective future therapeutic or preventive strategies.

  15. Effects of Co2+ on the erythromycin biosynthesis

    Institute of Scientific and Technical Information of China (English)

    DU Wen; CHEN Changhua

    2007-01-01

    Erythromycin biosynthesis is a highly complicated process,which involves both primary metabolism and secondary metabolism.The specific activities of the key enzymes related to glucose metabolism such as hexose kinase (HK),glucose-6-phosphate dehydrogenase(6-PDH),phosphofructokinase(PFK),and isocitrate dehydrogenase(ICD),were determined in Saccharopolyspora erythraea.The specitic activities of the enzymes involved in secondary metabolism,such as methylmalonyl-coenzyme A mutase (MCM)and methylmalonyl-coenzyme A transcarboxylase(MCT),were detected as well.Some organic acids contained in fermentation broth were also analyzed.The results show that Co2+ is able to increase erythromycin biosynthesis.It maybe due to Co2+ improving the specific activities of methylmalonyl-coenzyme A mutase and methylmalonyl-coenzyme A transcarboxylase.Meanwhile,it also enhances the flux of the glucose metabolism pathway.

  16. Controllable Biosynthesis and Properties of Gold Nanoplates Using Yeast Extract

    Institute of Scientific and Technical Information of China (English)

    Zhi Yang; Yasha Yi; Zhaohui Li; Xuxing Lu; Fengjiao He; Xingzhong Zhu; Yujie Ma; Rong He; Feng Gao; Weihai Ni

    2017-01-01

    Biosynthesis of gold nanostructures has drawn increasing concerns because of its green and sustainable synthetic process. However, biosynthesis of gold nanoplates is still a challenge because of the expensive source and difficulties of controllable formation of morphology and size. Herein, one-pot biosynthesis of gold nanoplates is proposed, in which cheap yeast was extracted as a green precursor. The morphologies and sizes of the gold nanostructures can be controlled via varying the pH value of the biomedium. In acid condition, gold nanoplates with side length from 1300 ± 200 to 300 ± 100 nm and height from 18 to 15 nm were obtained by increasing the pH value. Whereas, in neutral or basic condition, only gold nanoflowers and nanoparticles were obtained. It was determined that organic molecules, such as succinic acid, lactic acid, malic acid, and glutathione, which are generated in metabolism process, played important role in the reduction of gold ions. Besides, it was found that the gold nanoplates exhibited plasmonic property with prominent dipole infrared resonance in near-infrared region, indicating their potential in surface plasmon-enhanced applications, such as bioimaging and photothermal therapy.

  17. Building iPhone Apps with HTML, CSS, and JavaScript Making App Store Apps Without Objective-C or Cocoa

    CERN Document Server

    Stark, Jonathan

    2010-01-01

    What people are saying about Building iPhone Apps w/ HTML, CSS, and JavaScript "The future of mobile development is clearly web technologies like CSS, HTML and JavaScript. Jonathan Stark shows you how to leverage your existing web development skills to build native iPhone applications using these technologies." --John Allsopp, author and founder of Web Directions "Jonathan's book is the most comprehensive documentation available for developing web applications for mobile Safari. Not just great tech coverage, this book is an easy read of purely fascinating mobile tidbits in a fun colloquial

  18. The use of mobile apps to improve nutrition outcomes: A systematic literature review.

    Science.gov (United States)

    DiFilippo, Kristen N; Huang, Wen-Hao; Andrade, Juan E; Chapman-Novakofski, Karen M

    2015-07-01

    We conducted a systematic review to determine if the use of nutrition apps resulted in improved outcomes, including knowledge and behavior, among healthy adults. Using app(s), cellular phone, iPads, mobile phone, mobile telephone, smart phone, mobile and mHealth as search terms with diet, food and nutrition as qualifiers we searched PubMed, CINAHL (January 2008-October 2013) and Web of Science (January 2008-January 2014). Inclusion criteria were peer-reviewed randomized controlled trials, non-controlled trials, and cohort studies published in English that used apps to increase nutrition knowledge or improve behavior related to nutrition. Studies that were descriptive, did not include apps, focused on app development, app satisfaction app feasibility, text messaging, or digital photography were excluded. We evaluated article quality using the Academy of Nutrition and Dietetics Evidence Analysis Manual. Data was extracted for knowledge, behavior and weight change. Our initial search identified 12,010 titles from PubMed, 260 from CINAHL and 4762 from Web of Science; of these, only four articles met all search criteria. Positive quality ratings were given to three articles; only one reported knowledge outcomes (non-significant). All four articles evaluated weight loss and suggested an advantage to using nutrition apps. Behavioral changes in reviewed studies included increased adherence to diet monitoring (p app (p = 0.024). Few studies, however, have explored the use of nutrition apps as supportive educational interventions. Most apps focus on weight loss with inconsistent outcomes. We conclude that using apps for education needs additional research which includes behavior theory within the app and improved study design.

  19. Apps for asthma self-management: a systematic assessment of content and tools

    Directory of Open Access Journals (Sweden)

    Huckvale Kit

    2012-11-01

    Full Text Available Abstract Background Apps have been enthusiastically adopted by the general public. They are increasingly recognized by policy-makers as a potential medium for supporting self-management of long-term conditions. We assessed the degree to which current smartphone and tablet apps for people with asthma offer content and tools of appropriate quality to support asthma self-management. Methods We adapted systematic review methodology to the assessment of apps. We identified English-language asthma apps for all ages through a systematic search of official app stores. We systematically assessed app content using criteria derived from international guidelines and systematic review of strategies for asthma self-management. We covered three domains: comprehensiveness of asthma information, consistency of advice with evidence and compliance with health information best practice principles. Results We identified 103 apps for asthma in English, of which 56 were sources of information about the condition and 47 provided tools for the management of asthma. No apps offered both types of functionality. Only three information apps approached our definition of comprehensiveness of information about asthma. No apps provided advice on lay management of acute asthma that included details of appropriate reliever medication use. In 32 of 72 instances, apps made unequivocal recommendations about strategies for asthma control or prophylaxis that were unsupported by current evidence. Although 90% of apps stated a clear purpose, compliance with other best practice principles for health information was variable. Contact details were located for 55%, funding source for 18% and confidentiality policy for 17%. Conclusions No apps for people with asthma combined reliable, comprehensive information about the condition with supportive tools for self-management. Healthcare professionals considering recommending apps to patients as part of asthma self-management should exercise

  20. Sound level measurements using smartphone "apps": Useful or inaccurate?

    Directory of Open Access Journals (Sweden)

    Daniel R Nast

    2014-01-01

    Full Text Available Many recreational activities are accompanied by loud concurrent sounds and decisions regarding the hearing hazards associated with these activities depend on accurate sound measurements. Sound level meters (SLMs are designed for this purpose, but these are technical instruments that are not typically available in recreational settings and require training to use properly. Mobile technology has made such sound level measurements more feasible for even inexperienced users. Here, we assessed the accuracy of sound level measurements made using five mobile phone applications or "apps" on an Apple iPhone 4S, one of the most widely used mobile phones. Accuracy was assessed by comparing application-based measurements to measurements made using a calibrated SLM. Whereas most apps erred by reporting higher sound levels, one application measured levels within 5 dB of a calibrated SLM across all frequencies tested.

  1. Open Drug Discovery Teams: A Chemistry Mobile App for Collaboration.

    Science.gov (United States)

    Ekins, Sean; Clark, Alex M; Williams, Antony J

    2012-08-01

    The Open Drug Discovery Teams (ODDT) project provides a mobile app primarily intended as a research topic aggregator of predominantly open science data collected from various sources on the internet. It exists to facilitate interdisciplinary teamwork and to relieve the user from data overload, delivering access to information that is highly relevant and focused on their topic areas of interest. Research topics include areas of chemistry and adjacent molecule-oriented biomedical sciences, with an emphasis on those which are most amenable to open research at present. These include rare and neglected diseases, and precompetitive and public-good initiatives such as green chemistry. The ODDT project uses a free mobile app as user entry point. The app has a magazine-like interface, and server-side infrastructure for hosting chemistry-related data as well as value added services. The project is open to participation from anyone and provides the ability for users to make annotations and assertions, thereby contributing to the collective value of the data to the engaged community. Much of the content is derived from public sources, but the platform is also amenable to commercial data input. The technology could also be readily used in-house by organizations as a research aggregator that could integrate internal and external science and discussion. The infrastructure for the app is currently based upon the Twitter API as a useful proof of concept for a real time source of publicly generated content. This could be extended further by accessing other APIs providing news and data feeds of relevance to a particular area of interest. As the project evolves, social networking features will be developed for organizing participants into teams, with various forms of communication and content management possible.

  2. Galaxy Portal: Cross-platform app development and dissemination

    OpenAIRE

    Børnich, Claus

    2015-01-01

    This thesis presents the development of an app for mobile devices intended to access the Galaxy bioinformatics service to monitor the status of running analysis jobs. The Galaxy service is widely used in bioinformatics and uses a web-interface, but the interface design did not anticipate the rapid adoption of mobile technologies, such as smartphones and tablets, and so is difficult to use on a small touchscreen device. A bioinformatics project in Galaxy can often involve several steps where e...

  3. Android App Store架构设计与分析

    Institute of Scientific and Technical Information of China (English)

    胡波

    2013-01-01

      App Store即application store,通常理解为应用商店.用户可以在该应用商店浏览和购买或免费下载一些应用程序.App Store模式的意义在于为第三方软件的提供者提供方便而又高效的一个软件销售平台,第三方软件的提供者参与该平台的积极性可谓是空前高涨,这正适应手机用户们对个性化软件的需求,从而使得手机软件业开始进入一个高速、良性发展的轨道.主要就Android App Store业务架构及架构验证做一个全面的设计及详细分析.

  4. Mitigating App-DDoS Attacks on Web Servers

    Directory of Open Access Journals (Sweden)

    Manisha M. Patil

    2011-07-01

    Full Text Available In this paper, a lightweight mechanism is proposed to mitigate session flooding and request flooding app-DDoS attacks on web servers. App-DDoS attack is Application layer Distributed Denial of Service attack. This attack prevents legitimate users from accessing services. Numbers of mechanisms are available and can be installed on routers and firewalls to mitigate network layer DDoS attacks like SYNflood attack, ping of death attack. But Network layer solution is not applicable because App-DDoS attacks are indistinguishable based on packets and protocols. A lightweight mechanism is proposed which uses trust to differentiate legitimate users and attackers. Trust to client is evaluated based on his visiting history and requests are scheduled in decreasing order of trust. In this mechanism trust information is stored at client side in the form of cookies. This mitigation mechanism can be implemented as a java package which can run separately and forward valid requests to server. This mechanism also mitigates request flooding attacks by using Client Puzzle Protocol. When server is under request flooding attack source throttling is done by imposing cost on client. Cost is collected in terms of CPU cycles.

  5. Choosing between responsive-design websites versus mobile apps for your mobile behavioral intervention: presenting four case studies.

    Science.gov (United States)

    Turner-McGrievy, Gabrielle M; Hales, Sarah B; Schoffman, Danielle E; Valafar, Homay; Brazendale, Keith; Weaver, R Glenn; Beets, Michael W; Wirth, Michael D; Shivappa, Nitin; Mandes, Trisha; Hébert, James R; Wilcox, Sara; Hester, Andrew; McGrievy, Matthew J

    2016-11-03

    Both mobile apps and responsive-design websites (web apps) can be used to deliver mobile health (mHealth) interventions, but it can be difficult to discern which to use in research. The goal of this paper is to present four case studies from behavioral interventions that developed either a mobile app or a web app for research and present an information table to help researchers determine which mobile option would work best for them. Four behavioral intervention case studies (two developed a mobile app, and two developed a web app) presented include time, cost, and expertise. Considerations for adopting a mobile app or a web app-such as time, cost, access to programmers, data collection, security needs, and intervention components- are presented. Future studies will likely integrate both mobile app and web app modalities. The considerations presented here can help guide researchers on which platforms to choose prior to starting an mHealth intervention.

  6. Automated motive-based user review analysis in the context of mobile app acceptance: Opportunities and applications

    Directory of Open Access Journals (Sweden)

    Elisabeth Pergler

    2012-06-01

    Full Text Available The increasing amount and importance of user-generated content that is available in the web necessitates methods of its effective and efficient utilization. In this paper a system is presented that enables automated classification of user reviews concerning the usage motives mentioned in the reviews. Four possible applications of the system are discussed in detail in the course of this paper: a learning environment for mobile app development, a download prognosis mechanism, an app prizing decision support system, and a recommendation system. These applications are evaluated concerning state-of-the-art methods that currently address the challenge as well as advantages of the implementation of a motive-based system in the particular business processes.

  7. Monoterpene biosynthesis potential of plant subcellular compartments

    NARCIS (Netherlands)

    Dong, L.; Jongedijk, E.J.; Bouwmeester, H.J.; Krol, van der A.R.

    2016-01-01

    Subcellular monoterpene biosynthesis capacity based on local geranyl diphosphate (GDP) availability or locally boosted GDP production was determined for plastids, cytosol and mitochondria. A geraniol synthase (GES) was targeted to plastids, cytosol, or mitochondria. Transient expression in Nicotiana

  8. Biosynthesis and Genetic Engineering of Polyketides

    Institute of Scientific and Technical Information of China (English)

    ZHU Xiang-Cheng; WANG Qiao-Mei; SHEN Yue-Mao; DU Liang-Cheng; HUFFMAN Justin; GERBER Ryan; LOU Li-Li; XIE Yun-Xuan; LIN Ting; JORGENSON Joel; MARESCH Andrew; VOGELER Chad

    2008-01-01

    Polyketides are one of the largest groups of natural products produced by bacteria, fungi, and plants. Many of these metabolites have highly complex chemical structures and very important biological activities, including antibiotic, anticancer, immunosuppressant, and anti-cholesterol activities. In the past two decades, extensive investigations have been carried out to understand the molecular mechanisms for polyketide biosynthesis. These efforts have led to the development of various rational approaches toward engineered biosynthesis of new polyketides. More recently, the research efforts have shifted to the elucidation of the three-dimentional structure of the complex enzyme machineries for polyketide biosynthesis and to the exploitation of new sources for polyketide production, such as filamentous fungi and marine microorganisms. This review summarizes our general understanding of the biosynthetic mechanisms and the progress in engineered biosynthesis of polyketides.

  9. Sterols of the fungi - Distribution and biosynthesis

    Science.gov (United States)

    Weete, J. D.

    1973-01-01

    The importance of sterols in the growth and reproduction in fungi is becoming increasingly apparent. This article concerns the composition and biosynthesis of ergosterol in these organisms. Comparison to plant and animal sterol formation are made.

  10. 基于 HTML5的 Web App 的开发与探索%Development and Exploration of Web App Based on HTML5

    Institute of Scientific and Technical Information of China (English)

    章斓

    2015-01-01

    For the mobile Internet industry,the appearance of HTML5 brings about the powerful Web App with cross -platform compat-ibility.It is a page which could directly fit the phone screen,be operated conveniently on browsers,retain strong performance capaci-ty,provide real -time updates and offer user experience similar to Native App.This paper firstly introduces main features of Web App,expounds the realization of Web App based on HTML5 and analyzes opportunities and challenges for its development.%对于移动互联网行业来说,HTML5的出现带来了具有强大的跨平台兼容性的 Web APP———一种页面可直接适配手机屏幕、在浏览器上轻量运行、具有强大的表现能力、可实时更新且体验类似于 N-ative App 的网页应用。首先介绍了 Web App 的主要特点。在此基础上,阐述了基于 HTML5的 Web App 的实现。最后,分析了 Web APP 发展面临的机遇与挑战。

  11. 阻燃PU革用APP的硅烷偶联剂改性研究%Studies on the Modification of APP for Flame Retardant PU Leather with Silane Coupling Agent

    Institute of Scientific and Technical Information of China (English)

    王之婧; 徐一剡; 张玉洲; 邱芬飞; 葛芝君; 缪程平

    2015-01-01

    以KH-570作为硅烷偶联剂对阻燃剂APP进行表面偶联改性研究,讨论了原料配比、反应温度、反应时间等对改性效果的影响;通过工艺优化,改性APP 在水中的溶解度最高可下降91.24%。%The surface modification of flame retardant APP with KH-570 as the silane coupling anent was studied. And the effect of raw material ratio, reaction temperature, reaction time on the surface modification of APP were discussed. Through the process optimization, the solubility of APP in water was reduced of 91.24%.

  12. Simulation Apps Bring Us Closer to Mars

    Science.gov (United States)

    Knox, Jim

    2015-01-01

    My work with mathematical modeling and computer simulations began in earnest in 1987 when I signed on with the National Aeronautics and Space Administration, better known as NASA. At the time I was developing computer simulations to support the design of carbon dioxide (CO2) removal systems for the International Space Station (ISS) life support system. CO2 is a human metabolic waste, produced at a rate of a kilogram per day per crewmember. CO2 must be removed from the crew cabin, as it will quickly become detrimental to crew health. The systems used to remove CO2 are typically based on sorption processes, which include complex interactions of heat transfer, mass transfer, and gas flow through porous media. At this time, there were no commercial options for solving a set of coupled mathematical models such as partial differential equations (PDEs); you either force-fit the physics into a thermal analysis package or wrote your own code, complete with discretization, meshing, and solution algorithms. Unfortunately, coding CO2 removal processes from scratch did not allow an appropriate focus on the challenging yet crucial task of understanding and capturing the underlying physics via appropriate mathematical models. Configuration control was often simply ignored due to tight schedules, resulting in a code that would be quicker for a second party to rewrite than modify. In the early 2000s, I decided to move CO2 removal simulations to a platform with built-in meshing, solvers, and postprocessing capabilities, and that could solve user-defined multiphysics PDEs. The program chosen to meet these needs was COMSOL Multiphysics®. Along with freeing the engineer to focus on the underlying physics, a degree of configuration control was automatically achieved via a consistent user interface, thus allowing COMSOL users to share computer models. My team has developed simulations that are already providing a valuable debugging capability for the ISS CO2 removal system, and will

  13. Cross‐border use of WhatsApp, Pandora, and Grindr: on global norms and how to enforce these when there can be everywhere

    NARCIS (Netherlands)

    Lodder, A.R.

    2014-01-01

    Smart phones and tablets are becoming the main devices for accessing internet, and will outnumber the world population in 2016. Mobile Devices contain photos, contacts, unique identifiers, payment data, logs, etc., and are used everywhere, including abroad. apps process user information, including t

  14. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.

    Science.gov (United States)

    Chen, Ming; Wang, Jinzhao; Jiang, Jinxiang; Zheng, Xingzhi; Justice, Nicholas J; Wang, Kun; Ran, Xiangqian; Li, Yi; Huo, Qingwei; Zhang, Jiajia; Li, Hongmei; Lu, Nannan; Wang, Ying; Zheng, Hui; Long, Cheng; Yang, Li

    2017-01-05

    Amyloid precursor protein (APP) is enriched at the synapse, but its synaptic function is still poorly understood. We previously showed that GABAergic short-term plasticity is impaired in App knock-out (App(-/-)) animals, but the precise mechanism by which APP regulates GABAergic synaptic transmission has remained elusive. Using electrophysiological, biochemical, moleculobiological, and pharmacological analysis, here we show that APP can physically interact with KCC2, a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) homeostasis and fast GABAergic inhibition. APP deficiency results in significant reductions in both total and membrane KCC2 levels, leading to a depolarizing shift in the GABA reversal potential (EGABA). Simultaneous measurement of presynaptic action potentials and inhibitory postsynaptic currents (IPSCs) in hippocampal neurons reveals impaired unitary IPSC amplitudes attributable to a reduction in α1 subunit levels of GABAAR. Importantly, restoration of normal KCC2 expression and function in App(-/-) mice rescues EGABA, GABAAR α1 levels and GABAAR mediated phasic inhibition. We show that APP functions to limit tyrosine-phosphorylation and ubiquitination and thus subsequent degradation of KCC2, providing a mechanism by which APP influences KCC2 abundance. Together, these experiments elucidate a novel molecular pathway in which APP regulates, via protein-protein interaction with KCC2, GABAAR mediated inhibition in the hippocampus.

  15. Smartphone-Based Android app for Determining UVA Aerosol Optical Depth and Direct Solar Irradiances.

    Science.gov (United States)

    Igoe, Damien P; Parisi, Alfio; Carter, Brad

    2014-01-01

    This research describes the development and evaluation of the accuracy and precision of an Android app specifically designed, written and installed on a smartphone for detecting and quantifying incident solar UVA radiation and subsequently, aerosol optical depth at 340 and 380 nm. Earlier studies demonstrated that a smartphone image sensor can detect UVA radiation and the responsivity can be calibrated to measured direct solar irradiance. This current research provides the data collection, calibration, processing, calculations and display all on a smartphone. A very strong coefficient of determination of 0.98 was achieved when the digital response was recalibrated and compared to the Microtops sun photometer direct UVA irradiance observations. The mean percentage discrepancy for derived direct solar irradiance was only 4% and 6% for observations at 380 and 340 nm, respectively, lessening with decreasing solar zenith angle. An 8% mean percent difference discrepancy was observed when comparing aerosol optical depth, also decreasing as solar zenith angle decreases. The results indicate that a specifically designed Android app linking and using a smartphone image sensor, calendar and clock, with additional external narrow bandpass and neutral density filters can be used as a field sensor to evaluate both direct solar UVA irradiance and low aerosol optical depths for areas with low aerosol loads.

  16. A new android smartphone app for geospatial mapping from drones and kites

    Science.gov (United States)

    Anderson, Karen; Griffiths, Dave; Debell, Leon; Steve, Hancock; James, Duffy; Jamie, Shutler; Liam, Reinhardt; Griffiths, Amber; Threadgill, Katie

    2016-04-01

    sensing devices. The application uses a visual coding 'scheme blocks' framework, so that users can customise their own data capture tools in the field. In our presentation we will demonstrate the coding framework, and then we will show the results that were gathered when we used the app to collect data during test flights - utilising various kite and lightweight drone platforms. We have also developed a simple to use open-source geospatial toolkit to allow geographical information system (GIS)-ready GeoTIFF images to be processed from the metadata stored by the app. We will demonstrate how this works in our presentation. Two Android smartphones were used in testing - a high specification OnePlus One handset and a lower cost Acer Liquid Z3 handset. We will show that the best results were obtained with the higher specification phone when it was attached to a single line kite or to a gliding drone. Finally, we will use data collected using the app, over a farmyard to demonstrate the power of the resultant fine-grained products for a simple application - advising farmers about small-scale interventions they can make to improve the quality of water run-off from their farms. The app can be downloaded freely, and used wherever an Android smartphone and aerial platform are available to deliver rapid spatial data (e.g. disaster zones, in teaching or for grassroots democratic mapping). [https://play.google.com/store/apps/details?id=foam.uavtoolkit&hl=en

  17. Mobile Health Apps to Facilitate Self-Care: A Qualitative Study of User Experiences.

    Directory of Open Access Journals (Sweden)

    Kevin Anderson

    Full Text Available Consumers are living longer, creating more pressure on the health system and increasing their requirement for self-care of chronic conditions. Despite rapidly-increasing numbers of mobile health applications ('apps' for consumers' self-care, there is a paucity of research into consumer engagement with electronic self-monitoring. This paper presents a qualitative exploration of how health consumers use apps for health monitoring, their perceived benefits from use of health apps, and suggestions for improvement of health apps.'Health app' was defined as any commercially-available health or fitness app with capacity for self-monitoring. English-speaking consumers aged 18 years and older using any health app for self-monitoring were recruited for interview from the metropolitan area of Perth, Australia. The semi-structured interview guide comprised questions based on the Technology Acceptance Model, Health Information Technology Acceptance Model, and the Mobile Application Rating Scale, and is the only study to do so. These models also facilitated deductive thematic analysis of interview transcripts. Implicit and explicit responses not aligned to these models were analyzed inductively.Twenty-two consumers (15 female, seven male participated, 13 of whom were aged 26-35 years. Eighteen participants reported on apps used on iPhones. Apps were used to monitor diabetes, asthma, depression, celiac disease, blood pressure, chronic migraine, pain management, menstrual cycle irregularity, and fitness. Most were used approximately weekly for several minutes per session, and prior to meeting initial milestones, with significantly decreased usage thereafter. Deductive and inductive thematic analysis reduced the data to four dominant themes: engagement in use of the app; technical functionality of the app; ease of use and design features; and management of consumers' data.The semi-structured interviews provided insight into usage, benefits and challenges of

  18. Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids

    Directory of Open Access Journals (Sweden)

    Shinji Kishimoto

    2016-08-01

    Full Text Available Varieties of alkaloids are known to be produced by various organisms, including bacteria, fungi and plants, as secondary metabolites that exhibit useful bioactivities. However, understanding of how those metabolites are biosynthesized still remains limited, because most of these compounds are isolated from plants and at a trace level of production. In this review, we focus on recent efforts in identifying the genes responsible for the biosynthesis of those nitrogen-containing natural products and elucidating the mechanisms involved in the biosynthetic processes. The alkaloids discussed in this review are ditryptophenaline (dimeric diketopiperazine alkaloid, saframycin (tetrahydroisoquinoline alkaloid, strictosidine (monoterpene indole alkaloid, ergotamine (ergot alkaloid and opiates (benzylisoquinoline and morphinan alkaloid. This review also discusses the engineered biosynthesis of these compounds, primarily through heterologous reconstitution of target biosynthetic pathways in suitable hosts, such as Escherichia coli, Saccharomyces cerevisiae and Aspergillus nidulans. Those heterologous biosynthetic systems can be used to confirm the functions of the isolated genes, economically scale up the production of the alkaloids for commercial distributions and engineer the biosynthetic pathways to produce valuable analogs of the alkaloids. In particular, extensive involvement of oxidation reactions catalyzed by oxidoreductases, such as cytochrome P450s, during the secondary metabolite biosynthesis is discussed in details.

  19. Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum.

    Science.gov (United States)

    Kulis-Horn, Robert K; Persicke, Marcus; Kalinowski, Jörn

    2014-01-01

    l-Histidine biosynthesis is an ancient metabolic pathway present in bacteria, archaea, lower eukaryotes, and plants. For decades l-histidine biosynthesis has been studied mainly in Escherichia coli and Salmonella typhimurium, revealing fundamental regulatory processes in bacteria. Furthermore, in the last 15 years this pathway has been also investigated intensively in the industrial amino acid-producing bacterium Corynebacterium glutamicum, revealing similarities to E. coli and S. typhimurium, as well as differences. This review summarizes the current knowledge of l-histidine biosynthesis in C. glutamicum. The genes involved and corresponding enzymes are described, in particular focusing on the imidazoleglycerol-phosphate synthase (HisFH) and the histidinol-phosphate phosphatase (HisN). The transcriptional organization of his genes in C. glutamicum is also reported, including the four histidine operons and their promoters. Knowledge of transcriptional regulation during stringent response and by histidine itself is summarized and a translational regulation mechanism is discussed, as well as clues about a histidine transport system. Finally, we discuss the potential of using this knowledge to create or improve C. glutamicum strains for the industrial l-histidine production.

  20. Extra-gonadal sites of estrogen biosynthesis and function.

    Science.gov (United States)

    Barakat, Radwa; Oakley, Oliver; Kim, Heehyen; Jin, Jooyoung; Ko, CheMyong Jay

    2016-09-01

    Estrogens are the key hormones regulating the development and function of reproductive organs in all vertebrates. Recent evidence indicates that estrogens play important roles in the immune system, cancer development, and other critical biological processes related to human well-being. Obviously, the gonads (ovary and testis) are the primary sites of estrogen synthesis, but estrogens synthesized in extra- gonadal sites play an equally important role in controlling biological activities. Understanding non-gonadal sites of estrogen synthesis and function is crucial and will lead to therapeutic interventions targeting estrogen signaling in disease prevention and treatment. Developing a rationale targeting strategy remains challenging because knowledge of extra-gonadal biosynthesis of estrogens, and the mechanism by which estrogen activity is exerted, is very limited. In this review, we will summarize recent discoveries of extra-gonadal sites of estrogen biosynthesis and their local functions and discuss the significance of the most recent novel discovery of intestinal estrogen biosynthesis. [BMB Reports 2016; 49(9): 488-496].

  1. Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides

    Directory of Open Access Journals (Sweden)

    Jean-Luc eDo-Rego

    2012-01-01

    Full Text Available The enzymatic pathways leading to the synthesis of bioactive steroids in the brain are now almost completely elucidated in various groups of vertebrates and, during the last decade, the neuronal mechanisms involved in the regulation of neurosteroid production have received increasing attention. This report reviews the current knowledge concerning the effects of neurotransmitters, peptide hormones and neuropeptides on the biosynthesis of neurosteroids. Anatomical studies have been carried out to visualize the neurotransmitter- or neuropeptide-containing fibers contacting steroid-synthesizing neurons as well as the neurotransmitter, peptide hormones or neuropeptide receptors expressed in these neurons. Biochemical experiments have been conducted to investigate the effects of neurotransmitters, peptide hormones or neuropeptides on neurosteroid biosynthesis, and to characterize the type of receptors involved. Thus, it has been found that glutamate, acting through kainate and/or AMPA receptors, rapidly inactivates P450arom, and that melatonin produced by the pineal gland and eye inhibits the biosynthesis of 7-hydroxypregnenolone (7-OH-5P, while prolactin produced by the adenohypophysis enhances the formation of 7-OH-5P. It has also been demonstrated that the biosynthesis of neurosteroids is inhibited by GABA, acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors. In contrast, it has been shown that the octadecaneuropetide ODN, acting through central-type benzodiazepine receptors, the triakontatetraneuropeptide TTN, acting though peripheral-type benzodiazepine receptors, and vasotocine, acting through V1a-like receptors, stimulate the production of neurosteroids. Since neurosteroids are implicated in the control of various neurophysiological and behavioral processes, these data suggest that some of the neurophysiological effects exerted by neurotransmitters and neuropeptides may be mediated via the regulation

  2. Mixed-Methods Analysis of Factors Impacting Use of a Postoperative mHealth App

    Science.gov (United States)

    Scott, Aaron R; Alore, Elizabeth A; Naik, Aanand D; Berger, David H

    2017-01-01

    Background Limited communication and care coordination following discharge from hospitals may contribute to surgical complications. Smartphone apps offer a novel mechanism for communication and care coordination. However, factors which may affect patient app use in a postoperative, at-home setting are poorly understood. Objective The objectives of this study were to (1) gauge interest in smartphone app use among patients after colorectal surgery and (2) better understand factors affecting patient app use in a postoperative, at-home setting. Methods A prospective feasibility study was performed at a hospital that principally serves low socioeconomic status patients. After colorectal surgery, patients were enrolled and given a smartphone app, which uses previously validated content to provide symptom-based recommendations. Patients were instructed to use the app daily for 14 days after discharge. Demographics and usability data were collected at enrollment. Usability was measured with the System Usability Scale (SUS). At follow-up, the SUS was repeated and patients underwent a structured interview covering ease of use, willingness to use, and utility of use. Two members of the research team independently reviewed the field notes from follow-up interviews and extracted the most consistent themes. Chart and app log reviews identified clinical endpoints. Results We screened 115 patients, enrolled 20 patients (17.4%), and completed follow-up interviews with 17 patients (85%). Reasons for nonenrollment included: failure to meet inclusion criteria (47/115, 40.9%), declined to participate (26/115, 22.6%), and other reasons (22/115, 19.1%). There was no difference in patient ratings between usability at first-use and after extended use, with SUS scores greater than the 95th percentile at both time points. Despite high usability ratings, 6/20 (30%) of patients never used the app at home after hospital discharge and 2/20 (10%) only used the app once. Interviews revealed three

  3. Inter-dependent mechanisms behind cognitive dysfunction, vascular biology and Alzheimer’s dementia in Down syndrome: multi-faceted roles of APP

    Directory of Open Access Journals (Sweden)

    Dean eNizetic

    2015-12-01

    Full Text Available People with Down syndrome (DS virtually all develop intellectual disability (ID of varying degree of severity, and also have a high risk of early Alzheimer’s disease (AD. Intellectual disability prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced by many factors, and scarcely understood. Unravelling the causative factors and modulators of these processes remains a challenge, with potential to be informative for both ID and AD, for the development of early biomarkers and/or therapeutic approaches. We review the potential relative and inter-connected roles of the chromosome 21 gene for amyloid precursor protein (APP, in both pathological conditions. Rare non-DS people with duplication of APP (dupAPP get familial early onset AD (FEOAD with virtually 100% penetrance and prominent cerebrovascular pathology, but don’t suffer from ID before dementia onset. All of these features appear to be radically different in DS. On the other hand, rare individuals with partial trisomy 21 (T21 (with APP, but not DS-critical region in trisomy have been described having ID. Likewise, partial T21 DS (without APP trisomy show a range of ID, but no AD pathology. We review the multi-faceted roles of APP that might affect cognitive functioning. Given the fact that both Aβ secretion and synaptic maturation/plasticity are dependent on neuronal activity, we explore how this conflicting inter-dependency might affect cognitive pathogenesis in a dynamic way in DS, throughout the lifespan of an individual.

  4. An Empirical Assessment of a Technology Acceptance Model for Apps in Medical Education.

    Science.gov (United States)

    Briz-Ponce, Laura; García-Peñalvo, Francisco José

    2015-11-01

    The evolution and the growth of mobile applications ("apps") in our society is a reality. This general trend is still upward and the app use has also penetrated the medical education community. However, there is a lot of unawareness of the students' and professionals' point of view about introducing "apps" within Medical School curriculum. The aim of this research is to design, implement and verify that the Technology Acceptance Model (TAM) can be employed to measure and explain the acceptance of mobile technology and "apps" within Medical Education. The methodology was based on a survey distributed to students and medical professionals from University of Salamanca. This model explains 46.7% of behavioral intention to use mobile devise or "apps" for learning and will help us to justify and understand the current situation of introducing "apps" into the Medical School curriculum.

  5. eLearning Mobile App for Android and Ios "English Grammar Learn & Test"

    Directory of Open Access Journals (Sweden)

    Anca-Georgiana FODOR

    2016-11-01

    Full Text Available This article is aiming to present the architecture and few elements from the developing cycle of "English Grammar Learn & Test" app. This is an e-learning tool for people who want to improve their English Grammar and Vocabulary. The app was approved by Google Play and Apple Store and it is available for free on both platforms as following: Android: https://play.google.com/store/apps/details?id=com.labsterzz.english_tests iOS: https://itunes.apple.com/us/app/english-grammar-learn-test/id1126468980 The app already reached350.000 users, it is rated at 4.43out of maximum 5.0 in Google Play Store. Since mid-June 2016, we launched the app also in the Apple Store iOS devices.

  6. COMPARISON OF APP INVENTOR 2 AND JAVA IN CREATING PERSONAL APPLICATIONS FOR ANDROID ON EXAMPLE OF A NOTEPAD

    Directory of Open Access Journals (Sweden)

    Radosław Kowalczyk

    2016-09-01

    Full Text Available Nowadays, there is a common tendency to seek simpler and faster solutions that could be used in a process of software development. At the same time two other trends can be observed - rapid increase of mobile applications popularity and introducing IT concepts to non-IT specialists. This is why App Inventor 2 is one of the tools that software development community is interested in. The goal of this paper is to verify the possibility of using App Inventor as a tool for creating personal applications and compare it with possibilities given by Java, which is a native environment for Android platform. Comparison was based on application for managing personal text notes which was created in both solutions. The application had the same layout as well as analogical code, and it was the subject of performance tests followed by a survey. Performance test revealed that both implementations provided efficiency which is good enough for everyday use and small size personal applications. Survey participants preferred application built in Java due to its better responsiveness and visual appearance. Concluding, current shape of App Inventor, makes it useless for professionals, but useful for non-IT specialists for creating personal applications.

  7. Insulin biosynthesis and diabetes mellitus.

    Science.gov (United States)

    Permutt, A; Chirgwin, J; Giddings, S; Kakita, K; Rotwein, P

    1981-10-01

    This review reports the use of recombinant DNA techniques in the study of the structure and regulation of expression of insulin genes in man and experimental animals. Insulin biosynthesis by pancreatic islet cells is predominantly regulated by change in plasma glucose concentration. Using a cell-free protein synthesizing system as an assay of functional proinsulin messenger RNA (mRNA), and hybridization analysis with a cloned DNA complementary to proinsulin mRNA, it has been determined that through changes in proinsulin mRNA levels. Insulin genes of the rat, chicken and human have been isolated and sequenced. The 5' ends of the genes have similar sequences suggesting areas important for regulation of transcription. There are two non-allelic insulin genes in the rat, but only one in chickens and humans. Intervening sequences, areas of DNA transcribed into precursor mRNA but which do not appear in mature mRNA, have been described within insulin genes. The insulin gene resides on chromosome 11 of humans as determined by DNA hybridization analysis of mouse human hybrid cells. The structure of the insulin gene in genomic DNA of humans has been analyzed in diabetics and non-diabetics. Insertions of DNA between 1500 and 3400 base pairs have been detected near the transcription initiation site in 65% of type II diabetics, and 25-30% of non-diabetics (this difference is significant at the p less than 0.001 level). Limitation of these insertions to this potential promotor region of the insulin gene suggests that they may alter gene expression in type II diabetes. These insertions of DNA may prove to be useful genetic markers for diabetes.

  8. Security Recommendations for mHealth Apps: Elaboration of a Developer's Guide.

    Science.gov (United States)

    Morera, Enrique Pérez; de la Torre Díez, Isabel; Garcia-Zapirain, Begoña; López-Coronado, Miguel; Arambarri, Jon

    2016-06-01

    Being the third fastest-growing app category behind games and utilities, mHealth apps are changing the healthcare model, as medicine today involves the data they compile and analyse, information known as Big Data. However, the majority of apps are lacking in security when gathering and dealing with the information, which becomes a serious problem. This article presents a guide regarding security solution, intended to be of great use for developers of mHealth apps. In August 2015 current mobile health apps were sought out in virtual stores such as Android Google Play, Apple iTunes App Store etc., in order to classify them in terms of usefulness. After this search, the most widespread weaknesses in the field of security in the development of these mobile apps were examined, based on sources such as the "OWASP Mobile Security Project, the initiative recently launched by the Office of Civil Rights (OCR), and other articles of scientific interest. An informative, elemental guide has been created for the development of mHealth apps. It includes information about elements of security and its implementation on different levels for all types of mobile health apps based on the data that each app manipulates, the associated calculated risk as a result of the likelihood of occurrence and the threat level resulting from its vulnerabilities - high level (apps for monitoring, diagnosis, treatment and care) from 6 ≤ 9, medium level (calculator, localizer and alarm) from 3 ≤ 6 and low level (informative and educational apps) from 0 ≤ 3. The guide aims to guarantee and facilitate security measures in the development of mobile health applications by programmers unconnected to the ITC and professional health areas.

  9. Instagram and WhatsApp in Health and Healthcare: An Overview

    Directory of Open Access Journals (Sweden)

    Maged N. Kamel Boulos

    2016-07-01

    Full Text Available Instagram and WhatsApp are two social media and networking services introduced in 2010. They are currently subsidiaries of Facebook, Inc., California, USA. Using evidence from the published literature and case reports indexed in PubMed and other sources, we present an overview of the various applications of Instagram and WhatsApp in health and healthcare. We also briefly describe the main issues surrounding the uses of these two apps in health and medicine.

  10. CyTargetLinker: a cytoscape app to integrate regulatory interactions in network analysis.

    Directory of Open Access Journals (Sweden)

    Martina Kutmon

    Full Text Available INTRODUCTION: The high complexity and dynamic nature of the regulation of gene expression, protein synthesis, and protein activity pose a challenge to fully understand the cellular machinery. By deciphering the role of important players, including transcription factors, microRNAs, or small molecules, a better understanding of key regulatory processes can be obtained. Various databases contain information on the interactions of regulators with their targets for different organisms, data recently being extended with the results of the ENCODE (Encyclopedia of DNA Elements project. A systems biology approach integrating our understanding on different regulators is essential in interpreting the regulation of molecular biological processes. IMPLEMENTATION: We developed CyTargetLinker (http://projects.bigcat.unimaas.nl/cytargetlinker, a Cytoscape app, for integrating regulatory interactions in network analysis. Recently we released CyTargetLinker as one of the first apps for Cytoscape 3. It provides a user-friendly and flexible interface to extend biological networks with regulatory interactions, such as microRNA-target, transcription factor-target and/or drug-target. Importantly, CyTargetLinker employs identifier mapping to combine various interaction data resources that use different types of identifiers. RESULTS: Three case studies demonstrate the strength and broad applicability of CyTargetLinker, (i extending a mouse molecular interaction network, containing genes linked to diabetes mellitus, with validated and predicted microRNAs, (ii enriching a molecular interaction network, containing DNA repair genes, with ENCODE transcription factor and (iii building a regulatory meta-network in which a biological process is extended with information on transcription factor, microRNA and drug regulation. CONCLUSIONS: CyTargetLinker provides a simple and extensible framework for biologists and bioinformaticians to integrate different regulatory interactions

  11. Computational Thinking Oriented App Inventor Course Construction and Practice%面向计算思维的App Inventor课程建设与实践

    Institute of Scientific and Technical Information of China (English)

    吴明晖

    2015-01-01

    Aiming to promote the computational thinking ability cultivation , the course “App Inventor for Mobile Apps Developing” was built for the students without programming skills .App Inventor is a programming tool for Android apps with graphical building blocks , which is suitable for beginners .Based on the characters of App Inventor , the course has designed a series of interesting cases to induce related knowledge and skills . The teaching methods including case inducing , project driven , and competition integrated , which inspired students'interest and creative , and enhanced the cultivating of computational thinking .%针对大学计算思维能力的培养,以Android应用的图形化积木式编程软件App Inventor为载体,面向不具备编程基础的大一学生和非计算机专业大学生,建设了App Inventor移动应用开发课程。设计了系列趣味教学案例引导相关方法和技能,并融入计算思维培养。通过案例引导、项目驱动、学赛结合的教学方式,激发了学生兴趣和创意,增强了计算思维的培养。

  12. Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain

    Institute of Scientific and Technical Information of China (English)

    LI Zhidong; WANG Weiwei; ZHOU Fangfang; GAO Xia; PENG Gaonong; XU Huaxi; CHEN Ye-Guang

    2005-01-01

    Amyloid precursor protein (APP) plays a critical role in the formation of Alzheimer's disease (AD). The intracellular domain APP (AID) was suggested to cause neurotoxicity in the nucleus. To investigate the functions AID, yeast two-hybrid screening was performed to identify the proteins which interact with AID. The human brain cDNA library was screened using pGBKT7-AID as a bait, and several positive clones were identified. One of them encodes a part of the human stathmin-like 2 protein (STMN2). The interaction between STMN2 and APP implies that STMN2 may have an important function in APP-mediated AD formation.

  13. App Empire Make Money, Have a Life, and Let Technology Work for You

    CERN Document Server

    Mureta, Chad

    2012-01-01

    A guide to building wealth by designing, creating, and marketing a successful app across any platform Chad Mureta has made millions starting and running his own successful app business, and now he explains how you can do it, too, in this non-technical, easy-to-follow guide. App Empire provides the confidence and the tools necessary for taking the next step towards financial success and freedom. The book caters to many platforms including iPhone, iPad, Android, and BlackBerry. This book includes real-world examples to inspire those who are looking to cash in on the App gold rush. Learn how to s

  14. Efficacy of three-dimensional visualization in mobile apps for patient education regarding orthognathic surgery.

    Science.gov (United States)

    Pulijala, Y; Ma, M; Ju, X; Benington, P; Ayoub, A

    2016-09-01

    'Sur-face' is an interactive mobile app illustrating different orthognathic surgeries and their potential complications. This study aimed to evaluate the efficacy of Sur-face by comparing two methods of delivering patient information on orthognathic surgeries and their related potential complications: a mobile app with interactive three-dimensional (3D) animations and a voice recording containing verbal instructions only. For each method, the participants' acquired knowledge was assessed using a custom-designed questionnaire. Participants in the 'app' group performed significantly better (P3D visualizations in delivering information regarding orthognathic surgery and highlights the advantage of delivering validated patient information through mobile apps.

  15. Designing for Windows 8 fundamentals of great design in Windows Store apps

    CERN Document Server

    Schooley, Brent

    2013-01-01

    Designing for Windows 8 is a fast-paced, 150-page primer on the key design concepts you need to create successful Windows 8 apps. This book will help you design a user interface that is both delightful and effective, feels 'right' to your users, and encapsulates a great Windows 8 experience. In this book, you will: Meet the building blocks of solid Windows 8 UI design in a well-designed sample app. Learn how to incorporate key design elements into your apps, such as the app bar, charms and subtle animations from the animation library. Find out how to deliver the core experience that your users

  16. What Do Men Want from a Health Screening Mobile App? A Qualitative Study.

    Science.gov (United States)

    Teo, Chin Hai; Ng, Chirk Jenn; White, Alan

    2017-01-01

    There is a lack of mobile app which aims to improve health screening uptake developed for men. As part of the study to develop an effective mobile app to increase health screening uptake in men, we conducted a needs assessment to find out what do men want from a health screening mobile app. In-depth interviews and focus group discussions were conducted with 31 men from a banking institution in Kuala Lumpur. The participants were purposely sampled according to their job position, age, ethnicity and screening status. The recruitment was stopped once data saturation was achieved. The audio-recorded interviews were transcribed verbatim and analyzed using thematic approach. Three themes emerged from the analysis and they were: content, feature and dissemination. In terms of the content, men wanted the app to provide information regarding health screening and functions that can assess their health; which must be personalized to them and are trustable. The app must have user-friendly features in terms of information delivery, ease of use, attention allocation and social connectivity. For dissemination, men proposed that advertisements, recommendations by health professionals, providing incentive and integrating the app as into existing systems may help to increase the dissemination of the app. This study identified important factors that need to be considered when developing a mobile app to improve health screening uptake. Future studies on mobile app development should elicit users' preference and need in terms of its content, features and dissemination strategies to improve the acceptability and the chance of successful implementation.

  17. Substance Abuse and Mental Health Services Administration (SAMHSA) Behavioral Health Disaster Response App.

    Science.gov (United States)

    Seligman, Jamie; Felder, Stephanie S; Robinson, Maryann E

    2015-10-01

    The Substance Abuse and Mental Health Services Administration (SAMHSA) in the Department of Health and Human Services offers extensive disaster behavior health resources to assist disaster survivors in preparing for, responding to, and recovering from natural and manmade disasters. One of SAMHSA's most innovative resources is the SAMHSA Behavioral Health Disaster Response App (SAMHSA Disaster App). The SAMHSA Disaster App prepares behavioral health responders for any type of traumatic event by allowing them to access disaster-related materials and other key resources right on their phone, at the touch of a button. The SAMHSA Disaster App is available on iPhone, Android, and BlackBerry devices.

  18. MateriApps — a Portal Site of Materials Science Simulation

    Science.gov (United States)

    Konishi, Yusuke; Igarashi, Ryo; Kasamatsu, Shusuke; Kato, Takeo; Kawashima, Naoki; Kawatsu, Tsutomu; Kouta, Hikaru; Noda, Masashi; Sasaki, Shoichi; Terada, Yayoi; Todo, Synge; Tsuchida, Shigehiro; Yoshimi, Kazuyoshi; Yoshizawa, Kanako

    "MateriApps" is a portal website of computational materials science simulation that has a database containing over 100 application software including density functional theory calculation, quantum chemistry, molecular dynamics, etc. On the MateriApps website, researchers can find applications suitable for their own research in materials science by browsing the website or searching by keywords. We also provide forums and tutorial courses of applications. In order to avoid troublesome installation procedures and provide users an environment in which they can try out various applications easily, we develop and freely distribute "MateriApps LIVE!," a live Linux system, in which several applications introduced in MateriApps are pre-installed.

  19. Testing iOS apps with HadoopUnit rapid distributed GUI testing

    CERN Document Server

    Tilley, Scott

    2014-01-01

    Smartphone users have come to expect high-quality apps. This has increased the importance of software testing in mobile software development. Unfortunately, testing apps-particularly the GUI-can be very time-consuming. Exercising every user interface element and verifying transitions between different views of the app under test quickly becomes problematic. For example, execution of iOS GUI test suites using Apple's UI Automation framework can take an hour or more if the app's interface is complicated. The longer it takes to run a test, the less frequently the test can be run, which in turn re

  20. Transit apps for people with brain injury and other cognitive disabilities: the state of the art.

    Science.gov (United States)

    Livingstone-Lee, Sharon A; Skelton, Ronald W; Livingston, Nigel

    2014-01-01

    Individuals with cognitive disability have difficulty using public transit, but little research is directed toward this issue. Recent studies suggest that smartphones may be useful assistive devices in this context. Current objectives were to (1) survey research into difficulties people with cognitive disabilities experience when using public transit, (2) survey the current state of the art of transit and personal navigation applications (apps) and features, (3) recommend best existing transit apps for people with cognitive disability, and (4) recommend the best designs and features of these apps to developers of future transit apps. Potentially useful features were found in four categories: Transit apps for (1) individuals with cognitive disabilities and (2) healthy individuals, and personal navigation apps for (3) individuals with cognitive disabilities and (4) healthy individuals. A total of 159 apps were examined, but only seven were found specific to public transit for cognitive disability. By comparing research recommendations and currently available features, we identified several unmet needs. We note that there appears to be a shortage of apps for this population-function but that there is good research in the area and it is well suited to inform app development.