WorldWideScience

Sample records for bioscience limited anti-d

  1. The restricted use of IGHV3 superspecies genes in anti-Rh is not limited to hyperimmunized anti-D donors

    NARCIS (Netherlands)

    S.E. Dohmen; O.J.H.M. Verhagen; J. Muit; P.C. Ligthart; C.E. van der Schoot

    2006-01-01

    BACKGROUND: Antibodies produced against the D antigen make use of IGHV genes restricted to the IGHV3 superfamily. These findings are based on the IGHV gene analysis in anti-D-producing B cells from hyperimmunized donors, however, and therefore the restriction might be due to the hyperimmunization. I

  2. Synchrotron radiation in biosciences

    Science.gov (United States)

    Marinkovic, Nebojsa S.; Gupta, Sayan; Zhan, Chenyang; Chance, Mark R.

    2005-12-01

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  3. Synchrotron radiation in biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Marinkovic, Nebojsa S. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)]. E-mail: marinkov@bnl.gov; Gupta, Sayan [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Zhan, Chenyang [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Chance, Mark R. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)

    2005-12-15

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  4. Environmental Biosciences Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  5. Anti-D: mechanisms of action.

    Science.gov (United States)

    Ware, R E; Zimmerman, S A

    1998-01-01

    Immunoglobulin that recognizes and binds specifically to the erythrocyte D antigen (anti-D globulin, WinRho SDF; Nabi, Boca Raton, FL) has recently been shown to be an effective therapy for many patients with idiopathic thrombocytopenic purpura (ITP). Its mechanisms of action are not completely understood. Intravenous (IV) infusion of anti-D into a D-positive recipient leads to antibody coating of circulating erythrocytes that are cleared primarily by the spleen. This immune-mediated clearance of sensitized erythrocytes occupies the reticuloendothelial system and allows survival of antibody-coated platelets. Based on clinical observations, experimental data, and theoretical calculations, the efficacy of anti-D therapy in ITP depends on several factors that influence the amount of erythrocyte sensitization and the rate of immune-mediated erythrocyte clearance by the spleen. Antibody characteristics, including the antibody concentration, binding affinity, and dissociation constants, may be important, as well as the number of D-antigen binding sites on the erythrocytes. Although the primary mechanism of action of anti-D is believed to be immunologic blockade of Fc receptors (FcR) within the reticuloendothelial system (RES), other immunomodulatory effects are also possible. PMID:9523745

  6. Rhesus anti-D immunoglobulin in chronic autoimmune neuropathy

    NARCIS (Netherlands)

    de Jager, AEJ; van der Hoeven, JH

    1998-01-01

    Objective - To investigate the effect of Rhesus anti-D immunoglobulin (anti-D) in patients with an autoimmune demyelinating neuropathy. Material and methods - Three patients with an autoimmune mediated neuropathy received 1000 IU anti-D weekly for 2 months. Results - Two patients worsened gradually

  7. Environmental Biosciences First Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-09-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  8. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  9. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  10. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2008-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  11. Anti-D prophylaxis: past, present and future.

    Science.gov (United States)

    de Haas, M; Finning, K; Massey, E; Roberts, D J

    2014-02-01

    The new British Committee for Standards in Haematology (BCSH) guidelines for the use of anti-D immunoglobulin in pregnancy provide a welcome clarification of the use of anti-D in ectopic pregnancy and after red cell salvage during caesarean section, of dosing with different preparations and distinguishing non-immune and immune anti-D. The routine use of anti-D prophylaxis (RAADP) to prevent Rhesus (Rh) D alloimmunisation during the third trimester is well established and requires careful and well-audited local implementation to achieve the maximum public health benefit. In the UK, such scrutiny may be provided by the reporting of failed anti-D prophylaxis at women who have produced an immune anti-D that is detectable for the first time in the current pregnancy through the voluntary Serious Hazards of Transfusion reporting scheme (SHOT). Application of fetal RHD genotyping would avoid giving anti-D to RhD negative women carrying an RhD negative fetus. RAADP is directed by fetal RHD genotyping in some countries in Northern Europe led by the Netherlands and Denmark. The economic case for RAADP directed by fetal RHD genotyping needs to be carefully evaluated and in England is under consideration by National Institute for Health and Clinical Excellence (NICE). Possible future developments include the use of monoclonal anti-D preparations, now in advanced clinical trials, and also testing the hypothesis that directed RAADP from early in the second trimester may further reduce anti-D immunisation. PMID:25121157

  12. Anti-D prophylaxis: past, present and future.

    Science.gov (United States)

    de Haas, M; Finning, K; Massey, E; Roberts, D J

    2014-02-01

    The new British Committee for Standards in Haematology (BCSH) guidelines for the use of anti-D immunoglobulin in pregnancy provide a welcome clarification of the use of anti-D in ectopic pregnancy and after red cell salvage during caesarean section, of dosing with different preparations and distinguishing non-immune and immune anti-D. The routine use of anti-D prophylaxis (RAADP) to prevent Rhesus (Rh) D alloimmunisation during the third trimester is well established and requires careful and well-audited local implementation to achieve the maximum public health benefit. In the UK, such scrutiny may be provided by the reporting of failed anti-D prophylaxis at women who have produced an immune anti-D that is detectable for the first time in the current pregnancy through the voluntary Serious Hazards of Transfusion reporting scheme (SHOT). Application of fetal RHD genotyping would avoid giving anti-D to RhD negative women carrying an RhD negative fetus. RAADP is directed by fetal RHD genotyping in some countries in Northern Europe led by the Netherlands and Denmark. The economic case for RAADP directed by fetal RHD genotyping needs to be carefully evaluated and in England is under consideration by National Institute for Health and Clinical Excellence (NICE). Possible future developments include the use of monoclonal anti-D preparations, now in advanced clinical trials, and also testing the hypothesis that directed RAADP from early in the second trimester may further reduce anti-D immunisation.

  13. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2009-01-30

    Current research projects have focused Environmental Biosciences Program (EBP) talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene, low-dose ionizing radiation (gamma and neutron) and alpha radiation from plutonium. Trichloroethylene research has been conducted as a joint collaborative effort with the University of Georgia. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the United States Department of Energy (DOE). Laboratory work has been completed on several trichloroethylene risk assessment projects, and these projects have been brought to a close. Plans for restructuring the performance schedule of the remaining trichloroethylene projects have been submitted to the department. A comprehensive manuscript on the scientific basis of trichloroethylene risk assessment is in preparation. Work on the low-dose radiation risk assessment projects is also progressing at a slowed rate as a result of funding uncertainties. It has been necessary to restructure the proponency and performance schedule of these projects, with the project on Low-Dose Radiation: Epidemiology Risk Models transferred to DOE Office of Science proponency under a separate funding instrument. Research on this project will continue under the provisions of the DOE Office of Science funding instrument, with progress reported in accordance with the requirements of that funding instrument. Progress on that project will no longer be reported in quarterly reports for DE-FC09-02CH11109. Following a meeting at the Savannah River Site on May 8, 2008, a plan was submitted for development of an epidemiological cohort study and prospective medical surveillance system for the assessment of disease rates among workers at the Savannah River

  14. Monitoring and treatment of anti-D in pregnancy

    DEFF Research Database (Denmark)

    Bettelheim, D; Panzer, S; Reesink, H W;

    2010-01-01

    Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the in...

  15. Anti-D3's - Singular to the Bitter End

    OpenAIRE

    Iosif Bena; Mariana Grana; Stanislav Kuperstein(Institut de Physique Théorique, CEA Saclay, CNRS URA 2306, F-91191 Gif-sur-Yvette, France); Stefano Massai

    2012-01-01

    We study the full backreaction of anti-D3 branes smeared over the tip of the deformed conifold. Requiring the 5-form flux and warp factor at the tip to be that of anti-D3 branes, we find a simple power counting argument showing that if the three-form fluxes have no IR singularity, they will be necessarily imaginary-anti-self-dual. Hence the only solution with anti-D3 branes at the tip of the conifold that is regular in the IR and the UV is the anti-Klebanov-Strassler solution, and there is no...

  16. Supersymmetric D2 anti-D2 Strings

    OpenAIRE

    Bak, Dongsu; Ohta, Nobuyoshi

    2001-01-01

    We consider the flat supersymmetric D2 and anti-D2 system, which follows from ordinary noncommutative D2 anti-D2 branes by turning on an appropriate worldvolume electric field describing dissolved fundamental strings. We study the strings stretched between D2 and anti-D2 branes and show explicitly that the would-be tachyonic states become massless. We compute the string spectrum and clarify the induced noncommutativity on the worldvolume. The results are compared with the matrix theory descri...

  17. Nitrogen-15 reference book: medicine and biosciences

    International Nuclear Information System (INIS)

    A comprehensive bibliography on the application of the stable nitrogen isotope 15N in medicine, animal nutrition and physiology, biosciences, and related disciplines is presented. The literature pertaining to this paper covers the period from 1977 to 1981. The references are completed by an index of all authors and a subject index with special emphasis to the used organisms, labelled compounds, and tracer techniques, respectively. (author)

  18. The Application of Magnetic Techniques in Biosciences

    OpenAIRE

    Safarikova, M.; Safarik, I.

    2001-01-01

    The idea to use magnetic techniques in biosciences is not new, but it has enjoyed a resurgence of interest especially during the last two decades. Magnetic adsorbents, carriers and modifiers can be used for the immobilization, isolation, modification, detection, determination and removal of a variety of biologically active compounds, xenobiotics, cellular components and cells. Magnetic separation and labelling have recently found many useful and interesting applications in various areas of bi...

  19. On nonstandard finite difference schemes in biosciences

    Science.gov (United States)

    Anguelov, R.; Dumont, Y.; Lubuma, J. M.-S.

    2012-10-01

    We design, analyze and implement nonstandard finite difference (NSFD) schemes for some differential models in biosciences. The NSFD schemes are reliable in three directions. They are topologically dynamically consistent for onedimensional models. They can replicate the global asymptotic stability of the disease-free equilibrium of the MSEIR model in epidemiology whenever the basic reproduction number is less than 1. They preserve the positivity and boundedness property of solutions of advection-reaction and reaction-diffusion equations.

  20. Safety profile of WinRho anti-D.

    Science.gov (United States)

    Hong, F; Ruiz, R; Price, H; Griffiths, A; Malinoski, F; Woloski, M

    1998-01-01

    WinRho anti-D is manufactured with multiple processes to minimize the risk of transmitting blood-borne diseases such as viruses. These safety features include donor selection, plasma testing, solvent-detergent viral inactivation, and nanofiltration. To date, there has not been any case of viral transmission in association with use of WinRho anti-D. Adverse drug reactions are infrequent and generally mild; the most common are headache, fever, and chills. Some degree of hemolysis is inevitable due to the mechanism of action of WinRho anti-D, but this is predictable and transient. A few cases of intravascular hemolysis have been reported; hypersensitivity reactions are very rare. WinRho anti-D has been shown in both clinical trials and postmarketing surveillance to be safe and effective in the treatment of idiopathic thrombocytopenic purpura (ITP) and in the prevention of Rh isoimmunization. PMID:9523744

  1. Management of hypersensitivity reactions to anti-D immunoglobulin preparations.

    Science.gov (United States)

    Rutkowski, K; Nasser, S M

    2014-11-01

    RhD immunoglobulin G (anti-D) administered to pregnant Rh(-) women prevents Rh isoimmunization. Its use has significantly reduced the incidence of haemolytic disease of the foetus and newborn previously responsible for one death in every 2200 births. In pregnancy, acute drug-induced hypersensitivity reactions including anaphylaxis can have serious deleterious effects on the mother and foetus/neonate. Women can be erroneously labelled as drug allergic as the investigation of hypersensitivity reactions in pregnancy is complex and drug challenges are usually contraindicated. We present three cases of suspected anti-D hypersensitivity clinically presenting as anaphylaxis and delayed transfusion-related reaction. We also propose a new algorithm for the investigations of such reaction. It relies on detailed history, cautious interpretation of skin tests, foetal Rh genotyping from maternal blood and, in some cases, anti-D challenges. This is not to deprive women of anti-D which might put their future pregnancies at risk. PMID:25066207

  2. Developing Research Capabilities in Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Donald D

    2008-01-01

    Scientists founded the Life Sciences Research Foundation (LSRF) in 1983 as a non-profit pass through foundation that awards post doctoral fellowships in all areas of the life sciences. LSRF scientists review hundreds of applications each year from PhDs seeking support. For example this year, our 26th, we received 800 applications and our peer review committee will choose about 50 finalists who are eligible for these awards. We have no endowment so we solicit sponsors each year. The fellowships are sponsored by research oriented companies, foundations, philanthropists, the Howard Hughes Medical Institute, and other organizations who believe in the value of awarding fellowships to the best and the brightest young scientists. Our web site has a complete listing of all details about LSRF (http://www.lsrf.org/). In the late 1980s the Division of Bioscience in the Office of Basic Energy Science, a granting agency of the Department of Energy, joined this partnership. Bioscience's mandate was to support non-medical microbiology and plant sciences. LSRF received a series of 5 year grants from DOE to award fellowships to our top applicants in these fields of research. We began to support DOE-Energy Bioscience post doctoral fellows in 1989. From 1989 through 2004 when DOE funding ended our partnership awarded 41 DOE-Energy Bioscience Fellows of the Life Sciences Research Foundation. Each of these was a three year fellowship. DOE-Energy Biosciences was well matched with LSRF. Our extensive peer review screened applicants in all areas of the life sciences. Most LSRF sponsors are interested in supporting fellows who work on diseases. At the time that we began our partnership with DOE we had no sponsors willing to support plant biology and non medical microbiology. For 15 years DOE played a major role in the training of the very best young scientists in these important fields of research simply through its support of LSRF post doctoral fellows. Young scientists interested in

  3. Introducing bioinformatics, the biosciences' genomic revolution

    CERN Document Server

    Zanella, Paolo

    1999-01-01

    The general audience for these lectures is mainly physicists, computer scientists, engineers or the general public wanting to know more about what’s going on in the biosciences. What’s bioinformatics and why is all this fuss being made about it ? What’s this revolution triggered by the human genome project ? Are there any results yet ? What are the problems ? What new avenues of research have been opened up ? What about the technology ? These new developments will be compared with what happened at CERN earlier in its evolution, and it is hoped that the similiraties and contrasts will stimulate new curiosity and provoke new thoughts.

  4. D/antiD Dark Energy in String Warped Compactification

    CERN Document Server

    Piao, Y S

    2005-01-01

    We study the evolution of relic D3-branes in the bulk after D3/antiD3-brane inflation in string warped compactification. The motion of D3-branes can be frozen under certain condition during radiation/matter domination, and will be relaxed until D3/antiD3-branes potential starts to dominate the universe at late time. These relic D3-branes will be attract and move toward to antiD3-branes with the role of uplifting AdS minimum to dS's near the apex of throats. This provides a rapid channel inducing to the subsiding of dS vacuum with observed value. We discuss the required parameter spaces and calculate the decay time for this process.

  5. Review on D0-antiD0 mixing

    OpenAIRE

    Vidal, Fernando Martinez; Collaboration, on behalf the BaBar

    2009-01-01

    We review the current status of D0-antiD0 mixing, with special emphasis in the most recent results. We begin with a discussion of charm mixing and CP violation phenomenology, the evolution with the decay proper time, and physics processes contributing to these. Then we follow with the summary of the main experimental techniques and the results in the various final states. We make use of the analysis reporting the first evidence of D0-antiD0 mixing by BaBar in D0 -> K+ pi- decays as a textbook...

  6. Tachyon condensation in unbalanced D-anti D system

    OpenAIRE

    Ishida, Akira; Uehara, Shozo; Yada, Tomoki

    2006-01-01

    The tachyon condensation is studied in asymmetric D-anti D systems. Taking a system of two pairs of D5-anti D5 in type IIB superstring theory in the background of large N D5-branes, we show that one BPS D1-brane comes out after the condensation. It is also seen that the BPS D1-brane feels no force from the background D5-branes. We also show that the inclusion of the fluctuation fields gives an expected Dirac-Born-Infeld (DBI) action of the resultant D1-brane. On the other hand, in the case of...

  7. Review on D0 - Anti-D0 Mixing

    Energy Technology Data Exchange (ETDEWEB)

    Martinez-Vidal, Fernando; /Valencia U., IFIC

    2012-04-12

    We review the current status of D{sup 0}-{anti D}{sup 0} mixing, with special emphasis in the most recent results. We begin with a discussion of charm mixing and CP violation phenomenology, the evolution with the decay proper time, and physics processes contributing to these. Then we follow with the summary of the main experimental techniques and the results in the various final states. We make use of the analysis reporting the first evidence of D{sup 0}-{anti D}{sup 0} mixing by BaBar in D{sup 0} {yields} K{sup +}{pi}{sup -} decays as a textbook example, and then we discuss the results from other two-body and three-body final states. We conclude with the combination of all experimental results. Time-integrated CP violation measurements are not discussed here.

  8. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.d.

    2003-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  9. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  10. Environmental Biosciences Quarterly Report, September - December, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  11. Environmental Biosciences Program Report for Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-10-15

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  12. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  13. Environmental Biosciences Program Report for Year Three

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  14. Conference scene: Select Biosciences Epigenetics Europe 2010.

    Science.gov (United States)

    Razvi, Enal S

    2011-02-01

    The field of epigenetics is now on a geometric rise, driven in a large part by the realization that modifiers of chromatin are key regulators of biological processes in vivo. The three major classes of epigenetic effectors are DNA methylation, histone post-translational modifications (such as acetylation, methylation or phosphorylation) and small noncoding RNAs (most notably microRNAs). In this article, I report from Select Biosciences Epigenetics Europe 2010 industry conference held on 14-15 September 2010 at The Burlington Hotel, Dublin, Ireland. This industry conference was extremely well attended with a global pool of delegates representing the academic research community, biotechnology companies and pharmaceutical companies, as well as the technology/tool developers. This conference represented the current state of the epigenetics community with cancer/oncology as a key driver. In fact, it has been estimated that approximately 45% of epigenetic researchers today identify cancer/oncology as their main area of focus vis-à-vis their epigenetic research efforts. PMID:22126149

  15. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  16. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  17. Second Quarter Report Environmental Biosciences Program

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2002-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  18. Lessons on Ethical Decision Making from the Bioscience Industry

    OpenAIRE

    Novas, Carlos

    2006-01-01

    Novas discusses the implications of a new study in PLoS Medicine, in which executives and senior managers from bioscience firms were asked what their companies were doing to promote ethical behaviour.

  19. Introducing Advances in Bioscience and Clinical Medicine (ABCmed)

    OpenAIRE

    Samad EJ Golzari; Kamyar Ghabili

    2013-01-01

    We are pleased to announce the launch of the Advances in Bioscience and Clinical Medicine (ABCmed), aninternational open-access, and peer-reviewed journal. Mostly intended to cover all areas of bioscience and medicine, theJournal would provide a unique venue for the scientists from all over the world to publish their scientific works. One ofthe advantages of publishing with us is the rapid yet rigorous review process which is mostly performed by ourdistinguished Editorial and Review Board mem...

  20. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation s need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyles (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  1. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  2. Environmental Biosciences Program Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  3. Environmental Biosciences Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk based decision-making. Questions, comments or requests for further information concerning the activities under this

  4. Anti-D-brane as Dark Matter in Warped String Compactification

    OpenAIRE

    Mukohyama, Shinji

    2005-01-01

    It is pointed out that in the warped string compactification, motion of anti-D-branes near the bottom of a throat behaves like dark matter. Several scenarios for production of the dark matter are suggested, including one based on the D/anti-D interaction at the late stage of D/anti-D inflation.

  5. Intravenous anti-D treatment of immune thrombocytopenic purpura: analysis of efficacy, toxicity, and mechanism of effect.

    Science.gov (United States)

    Bussel, J B; Graziano, J N; Kimberly, R P; Pahwa, S; Aledort, L M

    1991-05-01

    The efficacy, toxicity, and mechanism of effect of intravenous Anti-D (Winrho) were studied in 43 Rh+ patients with immune thrombocytopenia purpura (ITP) who had not undergone splenectomy and in three already splenectomized patients. The mean platelet increase for the 43 nonsplenectomized patients was 95,000/microL (median 43,000/microL). Children had greater acute platelet responses than did adults. Human immunodeficiency virus status and duration of thrombocytopenia did not affect response. Maintenance treatment was given to patients as needed: the average interval between infusions was 24 days. The three splenectomized patients had no platelet response whatsoever. Toxicity was minimal; infusions were completed in less than 5 minutes. The generally accepted mechanism of effect of Anti-D has been Fc receptor blockade by substitution of antibody-coated red blood cells for antibody-coated platelets. Evidence is presented suggesting that the effect of IV Anti-D is not limited to Fc receptor blockade, including: (1) no correlation of parameters of hemolysis with platelet increase; (2) a 48- to 72-hour delay before platelet increase; (3) a tendency of the change in monocyte Fc receptor I expression to correlate with platelet increase; and (4) increased in vitro production of antibodies to sheep red blood cells following IV Anti-D infusion. PMID:1850307

  6. Teaching and learning about bioscience ethics with undergraduates.

    Science.gov (United States)

    Van Rooy, Wilhelmina; Pollard, Irina

    2002-01-01

    Bioscience ethics acts as a practical interface between science and bioethics. It links scientific endeavour and its application into adaptive forms of bioethical consensus. Its major elements are increased understanding of biological systems, responsible use of technology, and curtailment of ethnocentric debates in tune with new scientific insights. This paper briefly describes the students' learning experience gained from the vacation unit BIOL 240, Introduction to Bioscience Ethics, as taught in biology, Macquarie University. On the basis of our evidence students were overwhelmingly positive about their learning because the unit assisted them to better face dilemmas that arise from the application of science and technology. The structure also provided active engagement with the subject matter and preferred learning environments that supported and contested their understanding of concepts relevant to bioscience and bioethics. PMID:14741947

  7. Evidence for D0-anti-D0 Mixing

    CERN Document Server

    Aubert, B; Boutigny, D; Karyotakis, Yu; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Graugès-Pous, E; López, L; Palano, A; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes-Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Ronan, M T; Tackmann, K; Wenzel, W A; Del Amo-Sánchez, P; Hawkes, C M; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Schröder, T; Steinke, M; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Liu, F; Long, O; Shen, B C; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Williams, D C; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Brandt, T; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Bequilleux, J; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F R; Lutz, A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Fisher, P H; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, Gallieno; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; De La Vaissière, C; Hamon, O; Leruste, P; Malcles, J; Ocariz, J; Pérez, A; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M

    2007-01-01

    We present evidence for D0-anti-D0 mixing in D0 --> K+pi- decays from 384 fb^{-1} of e+e- colliding-beam data recorded near sqrt(s) 10.6 GeV with the BaBar detector at the PEP-II storage rings at SLAC. We find the mixing parameters x'^2 = [-0.22 +- 0.30 (stat.) +- 0.21 (syst.)] x 10^{-3} and y' = [9.7 +- 4.4 (stat.) +- 3.1 (syst.)] x 10^{-3}, and a correlation between them of -0.94. This result is inconsistent with the no-mixing hypothesis with a significance of 3.9 standard deviations. We measure R_D, the ratio of doubly Cabibbo-suppressed to Cabibbo-favored decay rates, to be [0.303 +- 0.016 (stat.) +- 0.010 (syst.)]%. We find no evidence for \\CP violation.

  8. Teaching Critical Appraisal to Sport & Exercise Sciences and Biosciences Students

    Science.gov (United States)

    Phillips, Anna C.

    2009-01-01

    Seminars were implemented to develop undergraduates' critical appraisal skills and their effectiveness was evaluated. Participants were 140 undergraduate students consisting of 103 students from Sport and Exercise Sciences and 37 from Biosciences. Four seminars were employed to develop and reinforce critical thinking and provide an opportunity for…

  9. Integrating anticipated nutrigenomics bioscience applications with ethical aspects

    NARCIS (Netherlands)

    Levesque, L.; Ozdemir, V.; Gremmen, B.; Godard, B.

    2008-01-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surro

  10. Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class

    Science.gov (United States)

    Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija

    2015-01-01

    University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…

  11. Turnover rate of anti-D IgG injected during pregnancy.

    OpenAIRE

    Eklund, J; M. Hermann; Kjellman, H; Pohja, P

    1982-01-01

    Anti-D IgG was injected into 15 Rh-negative women in the 28th week of gestation and into three non-pregnant women. The uptake of anti-D after the intramuscular injections was calculated by measuring the concentration of antibody in the plasma with an autoanalyser. The biological half life and the catabolic rate of anti-D IgG were calculated according to a compartmental model. The recovery in vivo of anti-D was an average 24% in the non-pregnant women and 21% in the pregnant women. The half li...

  12. Constrained superfields from an anti-D3-brane in KKLT

    OpenAIRE

    Vercnocke, Bert; Wrase, Timm

    2016-01-01

    The KKLT construction of dS vacua relies on an uplift term that arises from an anti-D3-brane. It was argued by Kachru, Pearson and Verlinde that this anti-D3-brane is an excited state in a supersymmetric theory since it can decay to a supersymmetric ground state. Hence the anti-D3-brane breaks supersymmetry spontaneously and one should be able to package all the world-volume fields on the anti-D3-brane into a four dimensional $\\cal{N}=1$ supersymmetric action. Here we extend previous results ...

  13. Maternal anti-D concentrations and outcome in rhesus haemolytic disease of the newborn.

    OpenAIRE

    Bowell, P; Wainscoat, J.S.; Peto, T E; Gunson, H H

    1982-01-01

    The relation between maternal anti-D concentrations, measured against the British working standard, and outcome of rhesus-sensitised pregnancies was studied. There is a clear relation between increasing anti-D concentrations and the chance of a severely affected baby. Of those pregnancies (78) where serial anti-D concentrations remained below 4 IU/ml, no baby had a cord haemoglobin below 10 g/dl and three had exchange transfusions. In contrast, of those mothers (106) with anti-D concentration...

  14. Gravitational backreaction of anti-D branes in the warped compactification

    OpenAIRE

    Koyama, Kayoko; Koyama, Kazuya

    2005-01-01

    We derive a low-energy effective theory for gravity with anti-D branes, which are essential to get de Sitter solutions in the type IIB string warped compactification, by taking account of gravitational backreactions of anti-D branes. In order to see the effects of the self-gravity of anti-D branes, a simplified model is studied where a 5-dimensional anti-de Sitter ({\\it AdS}) spacetime is realized by the bulk cosmological constant and the 5-form flux, and anti-D branes are coupled to the 5-fo...

  15. Constraint from D - anti-D Mixing in Left-Right Symmetric Models

    OpenAIRE

    Dutta, Bhaskar; Mimura, Yukihiro

    2007-01-01

    We study the constraint arising from the recently observed D - anti-D mixing in the context of supersymmetric models with left-right symmetry. In these models, the supersymmetric contributions in the mixing amplitudes of D - anti-D, K - anti-K and B - anti-B are all correlated. We compare the constraint from the D - anti-D mixing with the K - anti-K mixing and find that the D - anti-D mixing constrains the maximal supersymmetric contribution to the B_s - anti-B_s mixing amplitude. The maximal...

  16. Gravitational backreaction of anti-D branes in the warped compactification

    Science.gov (United States)

    Koyama, Kayoko; Koyama, Kazuya

    2005-09-01

    We derive a low-energy effective theory for gravity with anti-D branes, which are essential to get de Sitter solutions in the type IIB string-warped compactification, by taking account of gravitational backreactions of anti-D branes. In order to see the effects of the self-gravity of anti-D branes, a simplified model is studied where a five-dimensional anti-de Sitter (AdS) spacetime is realized by the bulk cosmological constant and the 5-form flux, and anti-D branes are coupled to the 5-form field by Chern Simon terms. The AdS spacetime is truncated by introducing UV and IR cut-off branes like the Randall Sundrum model. We derive an effective theory for gravity on the UV brane and reproduce the familiar result that the tensions of the anti-D branes give potentials suppressed by the fourth power of the warp factor at the location of the anti-D branes. However, in this simplified model, the potential energy never inflates the UV brane, although the anti-D branes are inflating. The UV brane is dominated by dark radiation coming from the projection of the five-dimensional Weyl tensor, unless the moduli fields for the anti-D branes are stabilized. We comment on the possibility of avoiding this problem in a realistic string theory compactification.

  17. Width difference in the D0-anti-D0 system

    OpenAIRE

    Petrov, Alexey A.

    2000-01-01

    The motivation most often cited in searches for D0-anti-D0 mixing lies with the possibility of observing a signal from new physics which dominates that from the Standard Model. We discuss recent theoretical and experimental results in D0-anti-D0 mixing, including new experimental measurements from CLEO and FOCUS collaborations and their interpretations.

  18. Risk factors for RhD immunisation despite antenatal and postnatal anti-D prophylaxis

    NARCIS (Netherlands)

    J.M. Koelewijn; M. de Haas; T.G.M. Vrijkotte; C.E. van der Schoot; G.J. Bonsel

    2009-01-01

    Objective To identify risk factors for Rhesus D (RhD) immunisation in pregnancy, despite adequate antenatal and postnatal anti-D prophylaxis in the previous pregnancy. To generate evidence for improved primary prevention by extra administration of anti-D Ig in the presence of a risk factor. Design C

  19. Dispatches from the Interface of Salivary Bioscience and Neonatal Research

    OpenAIRE

    KristinVoegtline; DouglasA.Granger

    2014-01-01

    The emergence of the interdisciplinary field of salivary bioscience has created opportunity for neonatal researchers to measure multiple components of biological systems non-invasively in oral fluids. The implications are profound and potentially high impact. From a single oral fluid specimen, information can be obtained about a vast array of biological systems (e.g., endocrine, immune, autonomic nervous system) and the genetic polymorphisms related to individual differences in their function...

  20. Bioscience methodologies in physical chemistry an engineering and molecular approach

    CERN Document Server

    D'Amore, Alberto

    2013-01-01

    The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

  1. Fluorescence lifetime imaging in biosciences: technologies and applications

    Institute of Scientific and Technical Information of China (English)

    Raluca NIESNER; Karl-Heinz GERICKE

    2008-01-01

    The biosciences require the development of methods that allow a non-invasive and rapid investigation of biological systems. In this aspect, high-end imaging tech-niques allow intravital microscopy in real-time, providing information on a molecular basis. Far-field fluorescence imaging techniques are some of the most adequate methods for such investigations. However, there are great differences between the common fluorescence imaging techniques, i.e., wide-field, confocal one-photon and two-photon microscopy, as far as their applicability in diverse bioscientific research areas is concerned. In the first part of this work, we briefly compare these techniques. Standard methods used in the biosciences, i.e., steady-state techniques based on the analy-sis of the total fluorescence signal originating from the sam-ple, can successfully be employed in the study of cell, tissue and organ morphology as well as in monitoring the macro-scopic tissue function. However, they are mostly inadequate for the quantitative investigation of the cellular function at the molecular level. The intrinsic disadvantages of steady-state techniques are countered by using time-resolved tech-niques. Among these fluorescence lifetime imaging (FLIM) is currently the most common. Different FLIM principles as well as applications of particular relevance for the biosci-ences, especially for fast intravital studies are discussed in this work.

  2. Anti-D auto-immunization in a patient with weak D type 4.0.

    Science.gov (United States)

    Ouchari, M; Chakroun, T; Abdelkefi, S; Romdhane, H; Houissa, B; Jemni Yacoub, S

    2014-03-01

    We report the case of a 56-year-old patient with blood group O+C-c+E-e+K-, followed for a myelodysplasic syndrome and treated by regular pheno-identical and compatible (RBCs) transfusion since December 2007. In June 2009, a positive crossmatch was found with 2 RBCs O+C-c+E-e+K-. A positive anti-body screening with a positive autocontrol was detected and anti-D was unidentified in the patient's serum. The DAT was positive (IgG) and elution identified an anti-D. The following assumptions were then made: it could be a partial D phenotype with anti-D alloantibodies or RH: 1 phenotype with an anti-D auto-antibodies. Molecular analysis by multiplex PCR and sequencing have depisted a weak D type 4.0 phenotype. In October 2009, over three months of RH:-1 RBC transfusion, the antibody screening and DAT (IgG) remained positive, and an eluate made from the patient's erythrocytes contained an anti-D. All these funding confirmed the autoimmune nature of the anti-D. This case report illustrates the importance of a well-conducted and immunohematological laboratories test in order to distinguish between auto- or allo-immune of anti-D in a RH: 1 poly-transfused patients. This distinction is of great importance for transfusion support. PMID:24365172

  3. Risk factors for RhD immunisation despite antenatal and postnatal anti-D prophylaxis

    OpenAIRE

    Koelewijn, JM; de Haas, M.; Vrijkotte, TGM; van der Schoot, CE; Bonsel, GJ

    2009-01-01

    Objective To identify risk factors for Rhesus D (RhD) immunisation in pregnancy, despite adequate antenatal and postnatal anti-D prophylaxis in the previous pregnancy. To generate evidence for improved primary prevention by extra administration of anti-D Ig in the presence of a risk factor. Design Case–control study. Setting Nation-wide evaluation of the Dutch antenatal anti-D-prophylaxis programme. Population Cases: 42 RhD-immunised parae-1, recognised by first-trimester routine red cell ant...

  4. Collaborative study to recalibrate the International Reference Preparation of Anti-D Immunoglobulin.

    OpenAIRE

    Gunson, H H; Bowell, P J; Kirkwood, T B

    1980-01-01

    A collaborative study involving nine independent assays by eight laboratories has recalibrated the anti-D concentration of the International Reference Preparation of Anti-D Immunoglobulin (68/417) in terms of the International Standard for Anti-Rho (anti-D) Incomplete Blood Typing Serum (64/16). This study was carried out when it was found that 68/419 had been calibrated not against 64/16, as originally intended, but inadvertently against another preparation. Based on the results, a revised r...

  5. Use of anti-D in an accident and emergency department.

    OpenAIRE

    Huggon, A M; Watson, D P

    1993-01-01

    A retrospective study was made of the use of anti-D in an accident and emergency (A&E) department in 1 month. Patients who are discharged home with a diagnosis of threatened miscarriage should have their blood group determined and anti-D should be given to those who are rhesus negative. We found that only 8/29 patients discharged from the department had their blood group determined and none of the rhesus negative patients was given anti-D. We have introduced a practical method of reminding me...

  6. Low incidence of anti-D alloimmunization following D+ platelet transfusion: The Anti-D Alloimmunization after D-incompatible Platelet Transfusions (ADAPT) study

    OpenAIRE

    Cid, Joan; Lozano, Miguel; Ziman, Alyssa; West, Kamille A.; O'Brien, Kerry L.; Murphy, Michael F; Wendel, Silvano; Vázquez, Alejandro; Ortín, Xavier; Hervig, Tor A.; Delaney, Meghan; Flegel, Willy A.; Yazer, Mark H.

    2014-01-01

    The reported frequency of D alloimmunization in D- recipients after transfusion of D+ platelets varies. This study was designed to determine the frequency of D alloimmunization, previously reported to be an average of 5%±2%. A primary anti-D immune response was defined as the detection of anti-D ≥28 days following the first D+ platelet transfusion. Data were collected on 485 D- recipients of D+ platelets in 11 centres between 2010-2012. Their median age was 60 (range 2-100) years. Diagnoses i...

  7. Study of the decays B->D_s1(2536)+ anti-D(*)

    OpenAIRE

    Aushev, T.

    2011-01-01

    We report a study of the decays B -> D_s1(2536)+ anti-D(*), where anti-D(*) is anti-D0, D- or D*-, using a sample of 657 x 10^6 B anti-B pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. The branching fractions of the decays B+ -> D_s1(2536)+ anti-D0, B0 -> D_s1(2536)+ D- and B0 -> D_s1(2536)+ D*- multiplied by that of D_s1(2536)+ -> (D*0K+ + D*+K0) are found to be (3.97+-0.85+-0.56) x 10^-4, (2.75+-0.62+-0.36) x 10^-4 and (5.01+...

  8. Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients.

    Science.gov (United States)

    Scaradavou, A; Woo, B; Woloski, B M; Cunningham-Rundles, S; Ettinger, L J; Aledort, L M; Bussel, J B

    1997-04-15

    We report the results of intravenous anti-D (WinRho, WinRho SD) therapy in 261 non-splenectomized patients treated at the New York Hospital-Cornell Medical Center over the period from 1987 to 1994. Children (n = 124) and adult patients (n = 137) with classic immune thrombocytopenic purpura (ITP; n = 156) or human immunodeficiency virus (HIV) related thrombocytopenia (n = 105) and acute (n = 75) or chronic (n = 186) disease at the time of the initial anti-D treatment were studied. In addition, 11 previously splenectomized patients were treated as a separate group. Our objectives were to evaluate the following. (1) Efficacy of anti-D: The response after the initial infusion was analyzed according to clinical parameters, such as patient's age, HIV status, gender, disease duration, pretreatment platelet count, and hemoglobin value, as well as treatment-related factors, including the dose of anti-D, the solvent detergent treatment of the preparation, and the type of administration. (2) Use of anti-D as maintenance therapy: The duration of response after the initial infusion and the results of subsequent treatments were evaluated. (3) Safety/toxicity of anti-D: Postinfusion reactions and hemoglobin decrease after treatment were studied. Anti-D is a safe treatment providing a hemostatic platelet increase in greater than 70% of the Rh+ non-splenectomized patients. The group with the best results is HIV- children, but all patient groups respond and the effect lasts more than 21 days in 50% of the responders. Duration of response is not influenced by HIV status; furthermore, HIV+ patients show no adverse effects on hemoglobin decrease or HIV disease progression. Patients with chronic ITP after splenectomy have minimal or no response to intravenous anti-D. PMID:9108386

  9. Comparison of dexamethasone and Anti-D Immune globulin for immune thrombocytopenia purpura in children

    OpenAIRE

    Abdollah Banihashem; Hamid Farhangi; Mojtaba Mousavi Bazaz; Zahra Badiee; Ali Ghasemi; Sara Hesari

    2014-01-01

    Different therapeutic options in children with immune thrombocytopenic purpura include observation alone, periodic treatment with corticosteroids, intravenous immunoglobulin (IVIG) or anti-D, chronic administration of immunosuppressive agents, and splenectomy. Preference of the type of therapy depends on the degree of thrombocytopenia and clinical bleeding manifestations. Dexamethasone is safe but its side effects are the main disadvantages for its usage. Anti-D is more expensive than dexamet...

  10. Immunologic effects of anti-D (WinRho-SD) in children with immune thrombocytopenic purpura.

    Science.gov (United States)

    Zimmerman, S A; Malinoski, F J; Ware, R E

    1998-02-01

    Intravenous immunoglobulin (IVIG) is an effective treatment for immune thrombocytopenic purpura (ITP) that induces transient blockade of the reticuloendothelial system (RES) with additional effects including alteration of T lymphocyte subsets and suppression of in vitro T lymphocyte proliferation. As anti-D also is an effective treatment for ITP, we investigated its in vitro and in vivo immunologic effects. The in vitro effects of various agents used in ITP therapy were compared using T lymphocyte proliferation assays. Anti-D caused significantly less inhibition than IVIG or dexamethasone, but non-specific protein was as suppressive as IVIG. Six children with chronic ITP were studied following anti-D administration. Patients received a single dose of anti-D (WinRho-SD, 50 microg/kg i.v. over 5 min) and were studied on day 0, day 7, and 1 month later. Anti-D did not affect T lymphocyte subsets including the T cell receptor variable beta repertoire, in vitro T lymphocyte proliferation to mitogens, recall antigens, or interleukin-2, in vitro IgG synthesis induced by pokeweed mitogen, or T lymphocyte cytokine mRNA levels. We conclude that anti-D has no demonstrable in vitro or in vivo effects on lymphocyte enumeration or function, and therefore likely is effective in the treatment of ITP primarily through RES blockade. PMID:9462545

  11. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends

    International Nuclear Information System (INIS)

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  12. Hepatitis C virus liver disease in women infected with contaminated anti-D immunoglobulin.

    LENUS (Irish Health Repository)

    Sheehan, M M

    2012-02-03

    Screening for hepatitis C virus (HCV) infection is carried out by detection of antibodies to the virus (enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA)) with confirmation by identification of HCV RNA genome in serum (polymerase chain reaction (PCR)). We describe the histological features on liver biopsy in 88 women with chronic HCV infection (serum positive on ELISA, RIBA and PCR) acquired from virus contaminated anti-D immunoglobulin. For the majority of these patients the time interval from virus infection to presentation was between 17 and 18 years. We separately assessed necroinflammatory disease activity and architectural features on liver biopsy and applied a scoring system which permitted semi-quantitative documentation of abnormal features. Only three women showed liver biopsies within normal limits (+\\/-focal steatosis). The remaining 85 cases showed a predominantly mild or moderate degree of disease activity with interface hepatitis (56.8% of cases), spotty necrosis, apoptosis and focal inflammation (88.6% of cases) and portal inflammation (90.9% of cases). Confluent necrosis was an uncommon finding (2.3% of cases). Assessment of architectural features showed normal appearance in 35.2% of biopsies. The predominant architectural abnormality noted was portal tract fibrosis. Ten per cent of cases, however, showed significant fibrous band and\\/or nodule formation.

  13. Call for Papers-Bioscience Methods(ISSN 1925-1920)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Bioscience Methods (BM) (ISSN 1925-1920) is a new launched, open access and peer-reviewed journal that dedicates to publish the original research papers involving in innovative technologies and novel experimental arts within the fields of biosciences.

  14. Students Turned Off by Turnitin? Perception of Plagiarism and Collusion by Undergraduate Bioscience Students

    Science.gov (United States)

    Thompsett, Andrew; Ahluwalia, Jatinder

    2010-01-01

    Research on undergraduate bioscience students and the incidence of plagiarism is still in its infancy and a key problem arises in gauging the perception of undergraduate students on plagiarism and collusion in biosciences subjects because of the lack of empirical data. The aim of this study was to provide qualitative data on the perceptions of…

  15. Prediction of a Zc(4000) D* anti D* state and relationship with the claimed Zc(4025)

    International Nuclear Information System (INIS)

    After discussing the OZI suppression of one light meson exchange in the interaction of D* anti D* with isospin I = 1, we study the contribution of the two-pion exchange to the interaction and the exchange of heavy vectors, J/ψ for diagonal transitions D* anti D* and D* for transitions of D* anti D* to J/ψ ρ. We find these latter mechanisms to be weak, but enough to barely bind the system in J = 2 with a mass around 4000 MeV, while the effect of the two-pion exchange is a net attraction, though weaker than that from heavy-vector exchange. We discuss this state and try to relate it to the Zc (4025) state, above the D* anti D threshold, claimed in an experiment at BES from an enhancement of the D* anti D* distribution close to threshold. Together with the results from a recent reanalysis of the BES experiment showing that it is compatible with a J = 2 state below threshold around 3990 MeV, we conclude that the BES experiment could show the existence of the state that we find in our approach. (orig.)

  16. Constrained superfields from an anti-D3-brane in KKLT

    Science.gov (United States)

    Vercnocke, Bert; Wrase, Timm

    2016-08-01

    The KKLT construction of dS vacua [1] relies on an uplift term that arises from an anti-D3-brane. It was argued by Kachru, Pearson and Verlinde [2] that this anti-D3-brane is an excited state in a supersymmetric theory since it can decay to a supersymmetric ground state. Hence the anti-D3-brane breaks supersymmetry spontaneously and one should be able to package all the world-volume fields on the anti-D3-brane into a four dimensional {N} = 1 supersymmetric action. Here we extend previous results and identify the constrained superfields that correspond to all the degrees of freedom on the anti-D3-brane. In particular, we show explicitly that the four 4D worldvolume spinors give rise to constrained chiral multiplets S and Y i , i = 1 , 2 , 3 that satisfy S 2 = SY i = 0. We also conjecture (and provide evidence in a forthcoming publication) that the vector field A μ and the three scalars ϕ i give rise to a field strength multiplet W α and three chiral multiplets H i that satisfy the constraints S{W}_{α }={overline{D}}_{overset{\\cdot }{α }}(S{overline{H}}^i)=0 . This is the first time that such constrained multiplets appear in string theory constructions.

  17. Division of Agro technology and Biosciences: Past, Present and Future

    International Nuclear Information System (INIS)

    In presenter speech, he outlined several topics regarding development of Agro technology and Biosciences Division from 31 years ago. This division started with Unit Sains Hidupan Liar under PUSPATI in 1981 and change their names to Program Isotop dan Sinaran dalam Biologi dan Pertanian under Nuclear Technology Unit (UTN) (1983). In 1990 their premise change to MINT-Tech Park. This program responsible for conducting research in agro technology using nuclear technology. Several achievements achieved by this division since established. They also succeed in mutating banana namely Novaria banana (1994), Tongkat Ali rice (1990), ground nut (2003), orchids, organic fertilizer and foliage in 2000. The vision of this division are to promote and enhance innovation and applications in nuclear technology to achieve security in food productivity, safety and quality and ecological awareness for economics competitiveness and vibrancy in agrobioindustry and community development. (author)

  18. Applications of computational tools in biosciences and medical engineering

    CERN Document Server

    Altenbach, Holm

    2015-01-01

     This book presents the latest developments and applications of computational tools related to the biosciences and medical engineering. It also reports the findings of different multi-disciplinary research projects, for example, from the areas of scaffolds and synthetic bones, implants and medical devices, and medical materials. It is also shown that the application of computational tools often requires mathematical and experimental methods. Computational tools such as the finite element methods, computer-aided design and optimization as well as visualization techniques such as computed axial tomography open up completely new research fields that combine the fields of engineering and bio/medical. Nevertheless, there are still hurdles since both directions are based on quite different ways of education. Often even the “language” can vary from discipline to discipline.

  19. Introducing Advances in Bioscience and Clinical Medicine (ABCmed

    Directory of Open Access Journals (Sweden)

    Samad EJ Golzari

    2013-07-01

    Full Text Available We are pleased to announce the launch of the Advances in Bioscience and Clinical Medicine (ABCmed, aninternational open-access, and peer-reviewed journal. Mostly intended to cover all areas of bioscience and medicine, theJournal would provide a unique venue for the scientists from all over the world to publish their scientific works. One ofthe advantages of publishing with us is the rapid yet rigorous review process which is mostly performed by ourdistinguished Editorial and Review Board members; this obviously hard-to-achieve goal would not be realized withouttheir continuous support and advice.Another distinguishing characteristic of ABCmed is the diversity of published items in each issue. The editorial team ofthe Journal has devoted separate sections to rather unknown yet interesting fields of the science for instance hypotheses,history of medicine, etc. In the first issue of ABCmed, the readers might refer to the two published hypotheseshighlighting the possible role of chamomile in the treatment of rheumatoid arthritis, and also the preventive effects oftadalafil together with nimodipine in subarachnoid hemorrhage-induced cerebral vasospasm.Letters to the Editor are one of the major sectors in the ABCmed providing not only further on the already publisheddata in the Journal, but also personal comments on the major public health concerns and medical issues. In the firstissue of the Journal, a very important cancer surgery complication is debated, introducing different strategies in the painmanagement of breast cancer patients.We hope that ABCmed will provide a basis to bring together the scientists from all over the globe with the same goal ofpromoting science.

  20. Low frequency of anti-D alloimmunization following D+ platelet transfusion: the Anti-D Alloimmunization after D-incompatible Platelet Transfusions (ADAPT) study.

    Science.gov (United States)

    Cid, Joan; Lozano, Miguel; Ziman, Alyssa; West, Kamille A; O'Brien, Kerry L; Murphy, Michael F; Wendel, Silvano; Vázquez, Alejandro; Ortín, Xavier; Hervig, Tor A; Delaney, Meghan; Flegel, Willy A; Yazer, Mark H

    2015-02-01

    The reported frequency of D alloimmunization in D- recipients after transfusion of D+ platelets varies. This study was designed to determine the frequency of D alloimmunization, previously reported to be an average of 5 ± 2%. A primary anti-D immune response was defined as the detection of anti-D ≥ 28 d following the first D+ platelet transfusion. Data were collected on 485 D- recipients of D+ platelets in 11 centres between 2010 and 2012. Their median age was 60 (range 2-100) years. Diagnoses included: haematological (203/485, 42%), oncological (64/485, 13%) and other diseases (218/485, 45%). Only 7/485 (1·44%; 95% CI 0·58-2·97%) recipients had a primary anti-D response after a median serological follow-up of 77 d (range: 28-2111). There were no statistically significant differences between the primary anti-D formers and the other patients, in terms of gender, age, receipt of immunosuppressive therapy, proportion of patients with haematological/oncological diseases, transfusion of whole blood-derived or apheresis platelets or both, and total number of transfused platelet products. This is the largest study with the longest follow-up of D alloimmunization following D+ platelet transfusion. The low frequency of D alloimmunization should be considered when deciding whether to administer Rh Immune Globulin to D- males and D- females without childbearing potential after transfusion of D+ platelets. PMID:25283094

  1. Case report: passively acquired anti-D in a D+ pregnant patient.

    Science.gov (United States)

    Holub, M P; Kitchen, K; Mensinger, E

    1999-01-01

    A sample was submitted for serologic evaluation from a pregnant patient with immune thrombocytopenic purpura (ITP) for possible transfusion in the future because of a decreased platelet count. Anti-D and -E were identified in the patient's serum using several antibody identification techniques, and anti-D was recovered in an acid eluate prepared from the patient's red cells. It was discovered that WinRho had been administered to treat the ITP. This product has been licensed for treatment of nonsplenectomized D+ children and adults with ITP to increase the platelet count. Administration of anti-D to D+ individuals for treatment of ITP can cause a red cell anemia. PMID:15373521

  2. Faulty blood typing misled by auto anti-D in AIHA.

    Science.gov (United States)

    Li, Guining; Chen, Fenghua; Rao, Shenzong; Hu, Lihua

    2014-04-01

    Pre-transfusion testing is a vital link to enhance patients' safety but may be influenced by heterotypic blood transfusion and disease. Previous history of blood transfusion most of time help us determine the blood type. On the other hand, it can also mislead technicians to a wrong conclusion. Anti-D, which is clinically important in hemolytic transfusion reaction, is either alloimmunized by transfusion, pregnancy or induced in certain diseases. Here, we reported a rare case with false blood identification interfered by heterotypic blood transfusion and auto anti-D in autoimmune hemolytic anemia (AIHA). PMID:24508149

  3. Uplifting the baryonic branch: a test for backreacting anti-D3-branes

    OpenAIRE

    Dymarsky, Anatoly; Massai, Stefano

    2014-01-01

    Placing D3 or anti-D3-branes at the tip of the Klebanov-Strassler background results in uplifting the baryonic branch of the moduli space of the dual field theory. In this paper we derive a mass formula for the scalar particle associated with the motion along the baryonic branch, from both open and closed string points of view. We show that both methods give the same mass at linear order in number of (anti)D3-branes, thus providing a comprehensive check for the recently found linearized super...

  4. Strong phases and D0-anti-D0 mixing parameters

    OpenAIRE

    Falk, Adam F.; Nir, Yosef; Petrov, Alexey A.

    1999-01-01

    We argue that there could be large, SU(3) violating resonance contributions to D -> K pi decays which would affect the extraction of the D0-anti-D0 mixing parameters from experiment. Such contributions can induce a large strong phase in the interference between the doubly Cabibbo suppressed and the mixing induced Cabibbo favored contributions to the D0 -> K^+ pi^- and anti-D0 -> K^- pi^+ decays. Consequently, the interpretation of a large, CP conserving interference term can involve a large m...

  5. The backreaction of anti-D3 branes on the Klebanov-Strassler geometry

    OpenAIRE

    Bena, Iosif; Giecold, Gregory; Graña, Mariana; Halmagyi, Nick; Massai, Stefano

    2013-01-01

    We present the full numerical solution for the 15-dimensional space of linearized deformations of the Klebanov-Strassler background which preserve the SU(2) X SU(2) X Z_2 symmetries. We identify within this space the solution corresponding to anti-D3 branes, (modulo the presence of a certain subleading singularity in the infrared). All the 15 integration constants of this solution are fixed in terms of the number of anti-D3 branes, and the solution differs in the UV from the supersymmetric so...

  6. Trends in anti-D immune globulin for childhood immune thrombocytopenia: Usage, response rates, and adverse effects

    OpenAIRE

    Long, Michelle; Kalish, Leslie A.; Neufeld, Ellis J.; Grace, Rachael F.

    2011-01-01

    In 2010, the Food and Drug Administration (FDA) added a black box warning to anti-D immune globulin (Rho(D) immune globulin, anti-D) for immune thrombocytopenia (ITP) to warn of the complications related to severe hemolysis. The objective of this retrospective medical record review was to examine recent trends in anti-D use to treat ITP and rates of adverse events in a single large pediatric hematology program. Over a 7-year period, 176 (35%) of 502 ITP patients at our center received anti-D....

  7. Anti-D treatment for pediatric immune thrombocytopenia: Is the bad reputation justified?

    Science.gov (United States)

    Yacobovich, Joanne; Abu-Ahmed, Sabreen; Steinberg-Shemer, Orna; Goldberg, Tracie; Cohen, Miriam; Tamary, Hannah

    2016-04-01

    The purpose of this study was to assess the efficacy and side effect profile of the repeated use of anti-D for the treatment of pediatric immune thrombocytopenia (ITP) in a large pediatric hematology center. We performed a retrospective analysis of patient records for children (aged 4 months-18 years) treated for ITP at Schneider Children's Medical Center of Israel from 1995-2015. Demographic and clinical data, reported adverse events, and therapy response were extracted from written and electronic files for all patients having received anti-D. Therapy response was defined as time to platelet count >30 x 10(9)/L. Thirty-six patients received 170 treatments of anti-D at a dose of 75 μg/kg. The majority were previously treated with corticosteroids and/or intravenous immunoglobulin (IVIG). Minimal adverse events were recorded including fever (3.5%), vomiting (2.9%), and headaches (1.7%). Notably only 1/170 treatments required blood transfusion and no life-threatening events occurred. The average time to platelets >30 x 10(9)/L was 2.3 days, with a median of 1 day, range 1-12 days. Despite the reported severe adverse events in mainly elderly patients, the use of anti-D can be safe and effective in carefully chosen, low-risk pediatric patients with ITP. PMID:27312170

  8. Risk Factors for RhD Immunisation Despite Antenatal and Postnatal Anti-D Prophylaxis COMMENT

    NARCIS (Netherlands)

    J.M. Koelewijn; M. de Haas; T.G.M. Vrijkotte; C.E. van der Schoot; G.J. Bonsel

    2010-01-01

    Despite routine antenatal and postnatal administration of anti-D immunoglobulin (Ig) during pregnancy and delivery in a previous pregnancy, 0.1% to 0.3% of women are found to have Rhesus D (RhD) antibodies in their next pregnancy. The primary aim of this case-control study was to identify causative

  9. A nation-wide fetal RHD screening programme for targeted antenatal and postnatal anti-D

    NARCIS (Netherlands)

    Haas, M. de; Ploeg, C.P.B. van der; Scheffer, P.G.; Verlinden, D.A.; Hirschberg, H.; Abbink, F.; Schoot, C.E. van der

    2012-01-01

    In the Netherlands, since 1 July 2011, both antenatal anti-D immunoprophylaxis (1000 IU in the 30th week of gestation) and postnatal prophylaxis (1000 IU) is administered to only those women for whom a fetal RHD typing, performed in week 27 of pregnancy, predicts the presence of a D-positive child.

  10. Lessons from CLEO and FOCUS Measurements of D0-anti-D0 Mixing Parameters

    OpenAIRE

    Bergmann, Sven; Grossman, Yuval; Ligeti, Zoltan; Nir, Yosef; Petrov, Alexey A.

    2000-01-01

    If the true values of the D0-anti-D0 mixing parameters lie within the one sigma ranges of recent measurements, then there is strong evidence for a large width difference, y > 0.01, and large SU(3) breaking effects in strong phases, \\delta > pi/4. These constraints are model independent, and would become stronger if M_{12}/Gamma_{12}

  11. Functional in vitro studies of recombinant human immunoglobulin G and immunoglobulin A anti-D

    DEFF Research Database (Denmark)

    Nielsen, Leif Kofoed; Green, Trine Hefsgaard; Norderhaug, Lars;

    2007-01-01

    The use of anti-D purified from human serum to prevent hemolytic disease of the fetus and newborn due to D is well established. Owing to supply and safety reasons, however, an unlimited and non-plasma-derived source of antibodies for Rhesus prophylaxis is needed....

  12. Search for D0--anti-D0 mixing in the decays D0 --> K+ pi- pi+ pi-

    CERN Document Server

    Aubert, B; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Del Amo-Sánchez, P; Barrett, M; Ford, K E; Hart, A J; Harrison, T J; Hawkes, C M; Morgan, S E; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, Y K; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Zheng, Y; Kim, H; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Corwin, L A; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Regensburger, J J; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martínez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihályi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H; al, et

    2006-01-01

    We present a search for D0--anti-D0 mixing in the decays D0 --> K+ pi- pi+ pi- using 230.4 fb-1 of data collected with the BaBar detector at the PEP-II e+ e- collider at SLAC. Assuming CP conservation, we measure the time-integrated mixing rate R_M = (0.019 +0.016/-0.015(stat.) +/- 0.002(syst.))%, and R_M K+ pi- pi0, we find R_M = (0.020 +0.011/-0.010)%, where the uncertainty is statistical only. We determine the upper limit R_M < 0.042% at the 95% confidence level, and we find the combined data are consistent with the no-mixing hypothesis at the 2.1% confidence level.

  13. Developing and evaluating effective bioscience learning activities for nursing students.

    Science.gov (United States)

    Salvage-Jones, Judith; Hamill, Jessie; Todorovic, Michael; Barton, Matthew J; Johnston, Amy N B

    2016-07-01

    Effective engagement of nursing students in the study of biosciences remains a challenge for many tertiary institutes. In this study we attempted to implement and then evaluate a simple hands-on intervention, consisting of a series of hands-on games and puzzles, to increase nursing student engagement with core concepts and anatomical learning involved in clinical anatomy and physiology. The study used a quazi-experimental longitudinal before and after design, to explore the effect of a learning intervention on student performance. Set across three different campuses of the same University, it included 1320 first year undergraduate nursing students from 2013 to 2014 who were studying Anatomy and Physiology. Students were exposed to the interventions or not, and concomitant academic performance, weekly quiz scores, performance in fortnightly worksheets and, across the semester, exam performance were compared. The results show that while the intervention appeared to increase academic performance in students on one campus (2013) compared to the other two, this difference was not sustained into 2014 when a bigger cohort was examined. Despite significant subjective student satisfaction and enthusiasm about these learning and teaching interventions, the data does not support the capacity of these activities to enhance student academic performance. Tertiary entrance scores, being a non-native English speakers and socio-economic status all had a bigger impact on student performance than engagement with fun anatomy and physiology activities. PMID:27428695

  14. Environmental Biosciences Program Third Quarter Report, Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  15. Environmental Biosciences Program Quarterly Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  16. MUSC Environmental Biosciences Program First Quarter Report May - June, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr

    2002-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC02-98CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  17. The analysis and quantification of a clonal B cell response in a hyperimmunized anti-D donor

    NARCIS (Netherlands)

    S.E. Dohmen; O.J.H.M. Verhagen; S.M. de Groot; L.M. Stott; R.C. Aalberse; S.J. Urbaniak; C.E. van der Schoot

    2006-01-01

    Healthy volunteers are hyperimmunized with RhD-positive red cells in order to obtain plasma containing high titres of anti-D immunoglobulin, which is used for the prevention of haemolytic disease of the fetus and newborn. We analysed the anti-D immune response in a donor who had been hyperimmunized

  18. The Role of CP violation in D0 anti-D0 Mixing

    OpenAIRE

    Blaylock, G.; Seiden, Abe; Nir, Y.

    1995-01-01

    In current searches for D0 anti-D0 mixing, the time evolution of ``wrong-sign'' decays is used to distinguish between a potential mixing signal and the dominant background from doubly-Cabibbo-suppressed decays. A term proportional to $\\Delta Mt$ in the expression for the time evolution is often neglected in theoretical discussions and experimental analyses of these processes. We emphasize that, in general, this term does not vanish even in the case of CP invariance. Furthermore, CP invariance...

  19. Maternal anti-D prophylaxis during pregnancy does not cause neonatal haemolysis

    OpenAIRE

    Maayan-Metzger, A; Schwartz, T; Sulkes, J; Merlob, P

    2001-01-01

    OBJECTIVE—To evaluate signs of haemolysis in babies of Rh-D negative mothers who underwent prophylaxis with anti-D immunoglobulin during pregnancy.
DESIGN—The following were evaluated in all babies of Rh-D negative mothers born within a three month period in our department: haemoglobin level, packed cell volume, mean corpuscular volume, reticulocytes, bilirubin level, and direct Coombs' test (direct anti-globulin test). The babies were divided into two groups according to...

  20. Occurrence of anti-D alloantibodies among pregnant women in Kasese District, Western Uganda

    OpenAIRE

    Mbalibulha Y; Muwanguzi E; Mugyenyi GR; Natukunda B

    2015-01-01

    Yona Mbalibulha,1 Enoch Muwanguzi,1 Godfrey R Mugyenyi,2 Bernard Natukunda1 1Department of Medical Laboratory Sciences, 2Department of Obstetrics and Gynecology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda Objectives: This study was undertaken to determine the distribution of ABO/RhD (rhesus D antigen) blood phenotypes, prevalence of anti-D alloantibodies, and the risk factors for alloimmunization among pregnant women in Kasese District, Western Uganda....

  1. Three methods to detect the predicted D anti D scalar meson X(3700)

    Energy Technology Data Exchange (ETDEWEB)

    Xiao, C.W.; Oset, E. [Institutos de Investigacion de Paterna, Departamento de Fisica Teorica and IFIC, Centro Mixto Universidad de Valencia-CSIC, Valencia (Spain)

    2013-04-15

    In analogy to the f{sub 0}(500), which appears as a {pi}{pi} resonance in chiral unitary theory, and the f{sub 0}(980), which appears as a quasibound K anti K state, the extension of this approach to the charm sector also predicts a quasibound D anti D state with mass around 3720 MeV, named as X(3700), for which some experimental support is seen in the e + e - {yields}J/ {psi}D anti D reaction close to the D anti D threshold. In the present work we propose three different experiments to observe it as a clear peak. The first one is the radiative decay of the {psi}(3770), {psi}(3770) {yields} {gamma}X(3700) {yields} {gamma}{eta}{eta}'. The second one proposes the analogous reaction {psi}(4040) {yields} {gamma}X(3700) {yields} {gamma}{eta}{eta}' and the third reaction is the e {sup +} e- {yields} J/{psi}X(3700) {yields} J/{psi}{eta}{eta}'. Neat peaks are predicted for all the reactions and the calculated rates are found within measurable range in present facilities. (orig.)

  2. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

    Directory of Open Access Journals (Sweden)

    Carol Kilkenny

    2014-02-01

    Full Text Available In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications themselves are not “fit for purpose”, meaning that incomplete reporting of relevant information effectively renders many publications of limited value as instruments to inform policy or clinical and scientific practice [1–21]. A recent review of clinical research showed that there is considerable cumulative waste of financial resources at all stages of the research process, including as a result of publications that are unusable due to poor reporting [22]. It is unlikely that this issue is confined to clinical research [2–14,16–20].

  3. Annual report and summaries of FY 1993 activities: Division of Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The mission of the Energy Biosciences program is to generate fundamental information about plants and non-health related microorganisms that will constitute the base for new biotechnologies as well as supply information to improve usages of such organisms in their current form. The collective aims are totally consistent with the Department of Energy`s objectives of developing alternate energy sources, replacements for otherwise fossil energy derived products and providing critical fundamental information for the preservation and restoration of environmental conditions affected by energy related activities. The EB program takes full advantage of its organizational locale in the Office of Basic Energy Sciences to directly interact with such disciplines as Materials Sciences, Chemistry, Engineering and Geosciences to promote cross-disciplinary research and planning activities. One of the major specific objectives of the EB program is to probe the enormous capabilities of the specified organisms to carry out biochemical conversions. The limitation to realization of entirely new products and processes via biotechnology is the lack of basic understanding of natural processes. Such knowledge will then afford the advantage of developing procedures to the benefit of people and their society in providing new products along with providing new employment possibilities. This document consists of abstracts of projects supported in FY 1993.

  4. Automatic categorization of diverse experimental information in the bioscience literature

    Directory of Open Access Journals (Sweden)

    Fang Ruihua

    2012-01-01

    Full Text Available Abstract Background Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM. This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD. We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI. It is being used in

  5. Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease

    OpenAIRE

    Ipe, Tina S.; Wilkes, Jennifer J.; Hartung, Helge D.; Westhoff, Connie M.; Chou, Stella T.; Friedman, David F.

    2015-01-01

    A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding o...

  6. B{sup 0} → D{sup 0} anti D{sup 0}K{sup 0}, B{sup +} → D{sup 0} anti D{sup 0}K{sup +}, and the scalar D anti D bound state

    Energy Technology Data Exchange (ETDEWEB)

    Dai, L.R. [Liaoning Normal University, Department of Physics, Dalian (China); Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Xie, Ju-Jun [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Oset, E. [Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China)

    2016-03-15

    We study the B{sup 0} decay to D{sup 0} anti D{sup 0}K{sup 0} based on the chiral unitary approach, which generates the X(3720) resonance, and we make predictions for the D{sup 0} anti D{sup 0} invariant mass distribution. From the shape of the distribution, the existence of the resonance below threshold could be induced. We also predict the rate of production of the X(3720) resonance to the D{sup 0} anti D{sup 0} mass distribution with no free parameters. (orig.)

  7. In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

    DEFF Research Database (Denmark)

    Nielsen, Leif K; Green, Trine H; Sandlie, Inger;

    2008-01-01

    A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D....

  8. Severe hemolytic transfusion reaction due to anti-D in a D+ patient with sickle cell disease.

    Science.gov (United States)

    Ipe, Tina S; Wilkes, Jennifer J; Hartung, Helge D; Westhoff, Connie M; Chou, Stella T; Friedman, David F

    2015-03-01

    A 5-year-old male with sickle cell disease presented with pain, dark urine, and fatigue 10 days after a red blood cell (RBC) transfusion. Laboratory evaluation demonstrated severe anemia, blood type O+, and anti-D in the serum. Anti-D in a D+ patient led to RH genotyping, which revealed homozygosity for RHD*DAU4 that encodes partial D antigen. Anti-D in this patient whose RBCs exclusively express partial D caused a delayed hemolytic transfusion reaction after exposure to D+ RBCs. The finding of anti-D in a D+patient should be investigated by molecular methods to help distinguish an alloantibody from an autoantibody. PMID:25171447

  9. High prevalence of anti-D antibodies among women of childbearing age at Centre Pasteur of Cameroon.

    OpenAIRE

    Belinga, Suzanne,; Ngo Sack, Françoise; Bilong, Catherine; Manga, Jeanne; Mengue, Marie-Ange; Tchendjou, Patrice,

    2009-01-01

    International audience We conducted a cross sectional retrospective study to determine anti-D and D-negative phenotype rates among Cameroonian women of reproductive age (15-44 years), in order to evaluate the importance of D alloimmunization. Analysis of the haematology laboratory records from January 2006 to December 2007 harvested 225 results for red blood cell alloantibody screening and 2460 D phenotypes. Anti-D rate was found to be high at 4% and not linked to women's parity. Three hun...

  10. Use of anti-D immunoglobulin in the treatment of threatened miscarriage in the accident and emergency department

    OpenAIRE

    Weinberg, L

    2001-01-01

    Background—The UK guidelines for the use of anti-D immunoglobulin for rhesus prophylaxis have been revised. Anti-D immunoglobulin is no longer recommended for Rh D negative women after a threatened miscarriage less than 12 weeks gestation. These patients are at risk of rhesus immunisation, and there should be a policy for their treatment in the accident and emergency (A&E) department.

  11. Intravenous anti-D immunoglobulin in the treatment of resistant immune thrombocytopenic purpura in pregnancy.

    Science.gov (United States)

    Sieunarine, K; Shapiro, S; Al Obaidi, M J; Girling, J

    2007-04-01

    A 35-week pregnant 38-year-old woman presented with isolated thrombocytopenia (platelet count 4 x 10(9)/l). Investigations confirmed immune thrombocytopenic purpura, and she received treatment with prednisolone and intravenous immunoglobulins with no increment in the platelet count. At 37 and 38 weeks of the pregnancy, she received two doses of WinRho (anti-D immunoglobulin) at 50 microg/kg. Five days later, with a platelet count of 46 x 10(9)/l, she had an uncomplicated normal vaginal delivery. WinRho is a useful adjunct to other first-line treatment modalities for immune thrombocytopenia in pregnancy. PMID:17309547

  12. Efficacy and long term effects of antenatal prophylaxis with anti-D immunoglobulin.

    OpenAIRE

    Thornton, J.G.; Page, C; Foote, G.; Arthur, G R; Tovey, L A; Scott, J S

    1989-01-01

    OBJECTIVE--To measure the safety and efficacy of antenatal treatment with anti-D immunoglobulin. DESIGN--Open study with historical controls. SETTING--Multicentre study in 17 hospitals in West Yorkshire. PATIENTS--1238 Rh negative women who delivered Rh positive infants after 34 weeks in their first pregnancy in 1980-1 (group 1) and 2000 similar primigravidas from 1978-9 (group 2). Obstetric data were collected for 616 women in group 1 who had a subsequent pregnancy, 536 similar women in grou...

  13. Anti Rh Hemolytic Disease due to Anti C Antibody: Is Testing for Anti D Antibodies Enough?

    OpenAIRE

    Negi, Gita; Singh, Gaur Dushyant

    2011-01-01

    Rh blood group system is a complex blood group system. Rh antibodies are produced in Rh negative individuals following exposure to foreign RBCs after transfusion or pregnancy. Anti C is a rare cause of hemolytic disease of newborn and is very scarcely reported in the literature. The aim of the present case report of Hemolytic disease caused by Anti C antibody is to bring out the fact that antibodies other than anti D should be considered in cases that give a suggestive history but no evidence...

  14. Burkitt Lymphoma Preceded by Autoimmune Hemolytic Anemia due to Anti-D Antibody.

    Science.gov (United States)

    Mizuno, Yoshimi; Shimura, Yuji; Horiike, Shigeo; Takimoto, Tomoko; Maegawa, Saori; Tanba, Kazuna; Matsumura-Kimoto, Yayoi; Sumida, Yukari; Tatekawa, Shotaro; Tsukamoto, Taku; Chinen, Yoshiaki; Mizutani, Shinsuke; Nagoshi, Hisao; Yamamoto-Sugitani, Mio; Matsumoto, Yosuke; Kobayashi, Tsutomu; Kuroda, Junya; Taniwaki, Masafumi

    2016-01-01

    We herein report a rare case of Burkitt lymphoma (BL) preceded by autoimmune hemolytic anemia (AIHA) caused by autoantibodies against D antigen. After a partial response to AIHA with prednisolone (PSL) treatment for 7 months, the patient developed BL with a t(8;22)(q24;q11.2) chromosomal translocation. Intensive immunochemotherapy, including rituximab, led to a complete response (CR) of BL; however, anti-D antibody remained detectable in the plasma and antibody-dissociated solution from erythrocytes, thus continuous therapy with PSL was necessary even after achievement of the CR. BL with AIHA is extremely rare, with only one previously reported case in the literature. PMID:27523004

  15. D7-anti-D7 bilayer: holographic dynamical symmetry breaking

    OpenAIRE

    Grignani, Gianluca; Kim, Namshik; Semenoff, Gordon W.

    2012-01-01

    We consider a holographic model of dynamical symmetry breaking in 2+1-dimenisons, where a parallel D7-anti-D7 brane pair fuse into a single object, corresponding to the U(1)XU(1)->U(1) symmetry breaking pattern. We show that the current-current correlation functions can be computed analytically and exhibit the low momentum structure that is expected when global symmetries are spontaneously broken. We also find that these correlation functions have poles attributable to infinite towers of vect...

  16. Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

    Science.gov (United States)

    Mayne, Lynne

    2012-01-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

  17. D-brane anti-D-brane system in string theory

    CERN Document Server

    Hyakutake, Y

    2003-01-01

    In this paper, we review a system of D-brane and anti-D-brane in type II superstring theories. [A. Sen, hep-th/9904207 and references there in; Y.Hyakutake, Master-Th., Doctor-Th. (in Japanese)] This system is unstable an tachyonic modes, which have negative mass squared, appear from open strings between D-brane and anti-D-brane. The effective field theory on the world-volume is described by U(1) x U(1) gauge theory with a complex tachyon field. Since the mass squared of the techyon field is negative, a tachyon potential would be like a wine bottle. In order to make the system stable, the tachyon rolls down the potential and gets some vacuum expectation value. This is called the tachyon condensation mechanism. During this mechanism, Dp-brane and anti-Dp-brane annihilate completely, if we admit Sen's conjecture. The suspicions between tachyon condensation and Hawking radiation are also discussed. (author)

  18. D-brane anti-D-brane system in string theory

    International Nuclear Information System (INIS)

    In this paper, we review a system of D-brane and anti-D-brane in type II superstring theories. [A. Sen, hep-th/9904207 and references there in; Y.Hyakutake, Master-Th., Doctor-Th. (in Japanese)] This system is unstable an tachyonic modes, which have negative mass squared, appear from open strings between D-brane and anti-D-brane. The effective field theory on the world-volume is described by U(1) x U(1) gauge theory with a complex tachyon field. Since the mass squared of the techyon field is negative, a tachyon potential would be like a wine bottle. In order to make the system stable, the tachyon rolls down the potential and gets some vacuum expectation value. This is called the tachyon condensation mechanism. During this mechanism, Dp-brane and anti-Dp-brane annihilate completely, if we admit Sen's conjecture. The suspicions between tachyon condensation and Hawking radiation are also discussed. (author)

  19. Comparison between IV immune globulin (IVIG) and anti-D globulin for treatment of immune thrombocytopenia: a randomized open-label study.

    Science.gov (United States)

    Eghbali, Aziz; Azadmanesh, Peyman; Bagheri, Bahador; Taherahmadi, Hasan; Sadeghi Sedeh, Bahman

    2016-08-01

    To compare the effect of IV immune globulin (IVIG) and anti-D globulin (anti-D) for treatment of immune thrombocytopenia (ITP) in children. A randomized, open-label, single-center clinical trial was carried out in Amir-Kabir Hospital (Arak, Iran). The study was performed on 60 children with acute and chronic ITP, aged from 1 to 15 years. Patients were randomly assigned (1:1) to 50 μg/kg anti-D or 1 g/kg IVIG. Platelet counting was performed at baseline and at 3, 7, and 14 days after treatment termination. Safety assessment was performed in all patients. Anti-D caused a quicker response on the 3rd day of treatment (P anti-D had lower rate of side effects including fever (P anti-D was associated with rapid rise of platelets compared to IVIG. In addition, anti-D treatment had acceptable safety profile. PMID:26991138

  20. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  1. Reflective Practice: A Place in Enhancing Learning in the Undergraduate Bioscience Teaching Laboratory?

    Science.gov (United States)

    Parry, Damian; Walsh, Cathy; Larsen, Carl; Hogan, Joanne

    2012-01-01

    Bioscience employers demand graduates with better practical competence. It is our supposition that, although undesirable, student learning is assessment driven and this is leading students to simply go through the motions in the practical setting (whether field work or laboratory based). In this intervention a Critical Incident Report was…

  2. Call for Papers--Bioscience Methods (ISSN 1925-1920)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Bioscience Methods (BM) (ISSN 1925-1920) is a new launched, open access and peer-revi- ewed journal that dedicates to publish the original research papers involving in innovative technologies and novel experimental arts within the fields ofbiosciences.

  3. Call for papers--Bioscience Methods (ISSN 1925-1920)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Bioscience Methods (BM) (ISSN 1925-1920) is a new launched, open access and peer-reviewed journal that dedicates to publish the original research papers involving in innovative technologies and novel experimental arts within the fields ofbiosciences.

  4. Call for papers—Bioscience Methods(ISSN 1925-1920)

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Bioscience Methods(BM)(ISSN 1925-1920) is a new launched,open access and peer-reviewed journal that dedicates to publish the original research papers involving in innovative technologies and novel experimental arts within the fields ofbiosciences.

  5. Development of an Electronic Role-Play Assessment Initiative in Bioscience for Nursing Students

    Science.gov (United States)

    Craft, Judy; Ainscough, Louise

    2015-01-01

    Devising authentic assessments for subjects with large enrolments is a challenge. This study describes an electronic role-play assessment for approximately 600 first-year nursing students to learn and apply pathophysiology (bioscience) concepts to nursing practice. Students used Microsoft Office PowerPoint[R] to prepare electronic role-plays both…

  6. Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets.

    Science.gov (United States)

    Kjaersgaard, Mimi; Aslam, Rukhsana; Kim, Michael; Speck, Edwin R; Freedman, John; Stewart, Donald I H; Wiersma, Erik J; Semple, John W

    2007-08-15

    Rh immune globulin (WinRho SDF; Cangene, Mississauga, ON, Canada) is an effective treatment for autoimmune thrombocytopenic purpura; however, maintaining a sustained supply for its use in autoimmune thrombocytopenic purpura and its primary indication, hemolytic disease of the newborn, makes the development of alternative reagents desirable. We compared Rh immune globulin and 6 human monoclonal anti-D antibodies (MoAnti-D) with differing isotypes and specificities for their ability to opsonize erythrocytes and inhibit platelet phagocytosis in an in vitro assay. Results demonstrated that opsonization of erythrocytes with Rh immune globulin significantly (P < .001) reduced phagocytosis of fluorescently labeled opsonized platelets in an Fc-dependent manner. Of the MoAnti-D that shared specificity but differed in isotype, only IgG3 antibodies could significantly (P < .001) inhibit platelet phagocytosis. In contrast, 2 MoAnti-D shared isotypes and differed in specificity; however, only one could significantly (P < .001) inhibit platelet phagocytosis. The results suggest that MoAnti-D epitope specificity and isotypes are critical requirements for optimal inhibition of opsonized platelet phagocytosis. PMID:17456719

  7. Does the enhancement observed in {gamma}{gamma}{yields}D anti D contain two P-wave higher charmonia?

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Dian-Yong; He, Jun [Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Institute of Modern Physics of CAS, Nuclear Theory Group, Lanzhou (China); Liu, Xiang [Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Matsuki, Takayuki [Tokyo Kasei University, Itabashi, Tokyo (Japan)

    2012-11-15

    We solve a new puzzle raised by the observation of an enhancement structure Z(3930) in {gamma}{gamma}{yields}D anti D. If categorizing Z(3930) as {chi} {sub c2}(2P), as suggested by Belle and BaBar, we must explain why {chi} {sub c0}(2P) dominantly decaying into D anti D is missing in the D anti D invariant mass spectrum. In this work, we propose that the Z(3930) enhancement structure may contain two P-wave higher charmonia {chi} {sub c0}(2P) and {chi} {sub c2}(2P). We show that this assumption is supported by our analysis of the D anti D invariant mass spectrum and cos{theta} {sup *} distribution of {gamma}{gamma}{yields}D anti D. This observation would not only provide valuable information of two P-wave higher charmonia {chi} {sub c0}(2P) and {chi} {sub c2}(2P), but also serve as the crucial test of our novel proposal to the observed enhancement structure Z(3930), especially at the forthcoming BelleII and the approved SuperB. (orig.)

  8. Stability of D brane-anti D brane systems in confining gauge theories

    Energy Technology Data Exchange (ETDEWEB)

    Ghoroku, Kazuo [Fukuoka Institute of Technology, Fukuoka (Japan); Nakamura, Akihiro [Kagoshima University, Department of Physics, Kagoshima (Japan); Toyoda, Fumihiko [Kinki University, School of Humanity-Oriented Science and Engineering, Iizuka (Japan)

    2011-01-15

    We study the stability of a special form of D brane embedding which is regarded as a bound state of D{sub n} and anti-D{sub n} brane embedded in a 10D supergravity background which is dual to a confining gauge theory. For D5 branes with U(1) flux, their bound-state configuration can be regarded as the baryonium vertex. For D branes of n=6 and 8 without the U(1) flux, their bound states have been used to introduce flavor quarks in the dual supersymmetric Yang-Mills theory. In any case, it would be important to ensure that they are free from tachyon instability. For all these cases, we could show their stability with respect to this point. (orig.)

  9. Stability of D brane-anti D brane systems in confining gauge theories

    Science.gov (United States)

    Ghoroku, Kazuo; Nakamura, Akihiro; Toyoda, Fumihiko

    2011-01-01

    We study the stability of a special form of D brane embedding which is regarded as a bound state of D n and anti-D n brane embedded in a 10D supergravity background which is dual to a confining gauge theory. For D5 branes with U(1) flux, their bound-state configuration can be regarded as the baryonium vertex. For D branes of n=6 and 8 without the U(1) flux, their bound states have been used to introduce flavor quarks in the dual supersymmetric Yang-Mills theory. In any case, it would be important to ensure that they are free from tachyon instability. For all these cases, we could show their stability with respect to this point.

  10. Rare and transient anti-D antibody response in D(-) liver transplant recipients transfused with D(+) red blood cells.

    Science.gov (United States)

    Burin des Roziers, N; Ibanez, C; Samuel, D; Francoz, C; Idri, S; François, A; Mortelecque, R; Bierling, P; Pirenne, F

    2016-07-01

    A retrospective analysis was conducted on 20 D(-) liver transplant (LT) recipients transfused with D(+) RBCs perioperatively and screened for RBC antibodies between 2 and 6 months later. None developed anti-D detectable by the indirect antiglobulin test. Two patients produced weak anti-D that reacted only with papain-treated RBCs at 10 and 11 days without any sign of immune haemolysis. Antibodies became quickly undetectable. These data suggest an unusual pattern of alloimmunization in LT recipients with rapid, weak and transient antibody response and support the safety of transfusing D(+) RBCs in most of D(-) patients during LT surgery. PMID:26918570

  11. Could Z{sub c} (4025) be a J{sup P} = 1{sup +} D* anti D* molecular state?

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Chun-Yu. [Third Military Medical University, Department of Physics, School of Biomedical Engineering, Chongqing (China); Liu, Yong-Lu; Huang, Ming-Qiu [National University of Defense Technology, College of Science, Hunan (China)

    2013-12-15

    We investigate whether the newly observed narrow resonance Z{sub c} (4025) can be described as a D* anti D* molecular state with quantum numbers J{sup P} = 1{sup +}. Using QCD sum rules, we consider contributions up to dimension six in the operator product expansion and work at leading order of {alpha}{sub s}. The mass obtained for this state is (4.05 {+-} 0.28) GeV. It is concluded that the D* anti D* molecular state is a possible candidate for Z{sub c} (4025). (orig.)

  12. Elliptic supertube and a Bogomol'nyi-Prasad-Sommerfield D2-brane--anti-D2-brane Pair

    OpenAIRE

    Cho, Jin-Ho; Oh, Phillial

    2001-01-01

    An exact solution, in which a D2-brane and an anti-D2-brane are connected by an elliptically tubular D2-brane, is obtained without any junction condition. The solution is shown to preserve one quarter of the supersymmetries of the type-IIA Minkowski vacuum. We show that the configuration cannot be obtained by "blowing-up" from some inhomogeneously D0-charged superstrings. The BPS bound tells us that it is rather composed of D0-charged D2-brane-anti-D2-brane pair and a strip of superstrings co...

  13. Emergence of spontaneously broken supersymmetry on an anti-D3-brane in KKLT dS vacua

    OpenAIRE

    Kallosh, Renata; Wrase, Timm

    2014-01-01

    The KKLT construction of de Sitter vacua includes an uplifting term coming from an anti-D3-brane. Here we show how this term can arise via spontaneous breaking of supersymmetry, based on the emergence of a nilpotent chiral supermultiplet on the world-volume of the anti-D3-brane. We establish and use the fact that both the DBI as well as the WZ term, with account of orientifolding, acquire a form of the Volkov-Akulov action. For an O3 orientifold involution of $\\mathbb{R}^{9,1}$ we demonstrate...

  14. Hemolytic disease of the fetus and newborn caused by anti-D and anti-S alloantibodies: a case report

    OpenAIRE

    Yousuf Rabeya; Abdul Aziz Suria; Yusof Nurasyikin; Leong Chooi-Fun

    2012-01-01

    Abstract Introduction Hemolytic disease of the fetus and newborn is most commonly caused by anti-D alloantibody. It is usually seen in Rhesus D (RhD)-negative mothers that have been previously sensitized. We report here a case of hemolytic disease of the fetus and newborn in a newborn baby caused by anti-D and anti-S alloantibodies, born to a mother who was RhD negative, but with no previous serological evidence of RhD alloimmunization. Case presentation A one-day-old Chinese baby boy was bor...

  15. Adverse effect of plasma exchange on anti-D production in rhesus immunisation owing to removal of inhibitory factors.

    OpenAIRE

    Barclay, G. R.; Greiss, M A; Urbaniak, S J

    1980-01-01

    Intensive plasma exchange was used to reduce the maternal anti-D concentration in case of severe rhesus haemolytic disease. Initially the concentration fell from 30 to 4 IU/ml, but after six exchanges it increased to 490 IU/ml despite continued exchanges, and intrauterine fetal death eventually ensued. The increase in the rate of maternal anti-D production coincided with, and may have resulted from, removal of plasma immuno-regulatory factors that inhibited in-vitro lymphocyte functions. Thes...

  16. Division of energy biosciences: Annual report and summaries of FY 1995 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

  17. The molecular biology revolution and the rise of bioscience megacentres in North America and Europe

    OpenAIRE

    Philip Cooke

    2004-01-01

    This paper focuses on 'triple helix' effects in biosciences. Scientific change can have profound socioeconomic effects. The molecular biology revolution tilted pharmaceuticals production away from its fine chemistry path dependence into microbiology and biotechnology. The key to any triple helix effects has thus shifted to universities and spinouts buttressed with burgeoning public funding, leaving 'big pharma' increasingly playing the role of licenser and marketer of bought-in therapeutic tr...

  18. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research †

    OpenAIRE

    Carol Kilkenny; Browne, William J.; Cuthill, Innes C; Michael Emerson; Altman, Douglas G.

    2014-01-01

    In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications...

  19. Preclinical imaging: an essential ally in modern biosciences.

    Science.gov (United States)

    Cunha, Lídia; Horvath, Ildiko; Ferreira, Sara; Lemos, Joana; Costa, Pedro; Vieira, Domingos; Veres, Dániel S; Szigeti, Krisztián; Summavielle, Teresa; Máthé, Domokos; Metello, Luís F

    2014-04-01

    Translational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical implementation in diagnostics and/or therapeutics. The development of high-resolution in vivo imaging technologies provides a unique opportunity for studying disease in real time, in a quantitative way, at the molecular level, along with the ability to repeatedly and non-invasively monitor disease progression or response to treatment. The greatest advantages of preclinical imaging techniques include the reduction of biological variability and the opportunity to acquire, in continuity, an impressive amount of unique information (without interfering with the biological process under study) in distinct forms, repeated or modulated as needed, along with the substantial reduction in the number of animals required for a particular study, fully complying with 3R (Replacement, Reduction and Refinement) policies. The most suitable modalities for small-animal in vivo imaging applications are based on nuclear medicine techniques (essentially, positron emission tomography [PET] and single photon emission computed tomography [SPECT]), optical imaging (OI), computed tomography (CT), magnetic resonance imaging (MRI), magnetic resonance spectroscopy imaging (MRSI), and ultrasound. Each modality has intrinsic advantages and limitations. More recently, aiming to overcome the inherent limitations of each imaging modality, multimodality devices designed to provide complementary information upon the pathophysiological process under study have gained popularity. The combination of high-resolution modalities, like micro-CT or micro-MRI, with highly sensitive techniques providing functional information, such as micro-PET or micro-SPECT, will

  20. Do the acute platelet responses of patients with immune thrombocytopenic purpura (ITP) to IV anti-D and to IV gammaglobulin predict response to subsequent splenectomy?

    Science.gov (United States)

    Bussel, J B; Kaufmann, C P; Ware, R E; Woloski, B M

    2001-05-01

    The acute platelet response to Intravenous Gammaglobulin (IVIG) has been reported to predict response to subsequent splenectomy of patients with ITP. The current study was undertaken to determine if the platelet response to IV anti-D (Winrho-SDF) predicts response to subsequent splenectomy. The 61 HIV-uninfected children and adults in this study had taken part in the pre-licensing studies of IV anti-D and were all those who not only had evaluable platelet responses to IV anti-D but also had undergone splenectomy and had information available describing its 1-year outcome. Results of treatment with IVIG were available in 38 of these 61 patients. Neither response to the initial infusion of IV anti-D, nor response to the initial or last IVIG, predicted the response in either children or adults to subsequent splenectomy. However, response to the last anti-D infusion in adults was strongly correlated (P = 0.003) to response to subsequent splenectomy as was hemolysis >/=2.0 gm/dl after IV anti-D (P = 0.03). There was no overall relationship between response to IV anti-D or IVIG, and response to subsequent splenectomy. However, a good platelet response in adults to the last IV anti-D and a hemoglobin decrease >/=2.0 gm/dl both appeared to predict response to subsequent splenectomy. PMID:11279654

  1. An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study

    NARCIS (Netherlands)

    S.J. Thorpe; B. Fox; A.B. Heath; M. Scott; M. de Haas; S. Kochman; A. Padilla

    2006-01-01

    Background and Objectives The aim of this study was to evaluate a lyophilized monoclonal immunoglobulin M (IgM) anti-D preparation for use as an International Standard to specify a recommended minimum acceptable potency of anti-D blood-grouping reagents. Materials and Methods The candidate Internati

  2. Prevención de la isoinmunización materna al RhD, con gamma-globulina anti-D Prevention of maternal RhD isoimmunization with anti-D gamma globulin

    Directory of Open Access Journals (Sweden)

    Héctor Alfredo Baptista-González

    2001-02-01

    Full Text Available OBJETIVO: Presentar la experiencia institucional en la prevención de la isoinmunización al RhD, mediante el empleo de 150 µg de gamma-globulina anti-D en las mujeres Rh negativo. MATERIAL Y MÉTODOS: Se registraron los antecedentes inmunohematológicos de los casos consecutivos de todas las mujeres Rh negativo que acudieron, para su atención médica, al Instituto Nacional de Perinatología entre 1982 y 1995. A las mujeres con riesgo de isoinmunización se les aplicó 150 µg de gamma-globulina anti-D, con fines preventivos. RESULTADOS: En el periodo de estudio ingresaron 4 857 mujeres Rh negativo (4.85% del total de mujeres, de las cuales 629 (13.0%, presentaron isoinmunización al RhD. De estas últimas, 542 (86.2% ya se encontraron isoinmunizadas desde antes de su ingreso al Instituto. En 22 casos (3.5%, la isoinmunización ocurrió a pesar de que recibieron la dosis adecuada de gamma-globulina anti D. De las 2 605 pacientes (53.6% sometidas a prevención, a 2 039 se les aplicó una sola dosis, y a 475, hasta dos dosis. En 22 casos se documentó la falla de la prevención; sin embargo, en cuatro de ellos, se registraron embarazos múltiples, y los restantes 18 presentaron patología obstétrica asociada. CONCLUSIONES: Mediante este programa de prevención, consistente en administrar 150 µg de gamma-globulina anti-D por dosis, es posible reducir la isoinmunización a menos de un caso por cada 1 000 mujeres. Los fracasos en la prevención de la isoinmunización se asociaron a condiciones obstétricas agregadas y al incumplimiento de las guías o lineamientos del programa. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.htmlOBJECTIVE: To report our experience in preventing RhD maternal isoimmunization by using anti-D gamma globulin among Rh-negative women. MATERIAL AND METHODS: Between 1982 and 1995, immunologic and hematologic data were collected from all Rh-negative women seen at Mexico

  3. Taming the supergravity description of non-BPS D-branes: the D/anti-D solution

    Science.gov (United States)

    Bain, Pascal

    2001-04-01

    We obtain the supergravity solution which describes a bound state of D-string/anti-D-string pairs attached to different fixed planes of an orbifold, in type-IIB string theory compactified on T4/Bbb Z2. For parameters at which the conformal field theory point of view predicts stability, the solution displays a repulson-like singularity. However, we observe that a D-string/anti-D-string pair probe in this background becomes tensionless before reaching the singularity, suggesting a resolution by the enhançon mechanism. Moreover, the force feels by this probe is attractive, in contrast to the repulsive behaviour observed in the non-BPS D-brane description.

  4. Measurement of the D0 - anti-D0 lifetime difference using D0 -> Kpi/KK decays

    OpenAIRE

    Abe, K.

    2003-01-01

    We report a preliminary measurement of the D0-anti-D0 mixing parameter y_CP and the CP-violating parameter A_G using the decay D*+ -> D0 pi+ followed by D0 -> K- pi+ and D0 -> K+ K-. The results are obtained from a 158 fb^-1 data sample collected near the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric energy e+ e- collider.

  5. Thrombocytopenia associated with dengue hemorrhagic fever responds to intravenous administration of anti-D (Rh(0)-D) immune globulin.

    Science.gov (United States)

    de Castro, Reynaldo Angelo C; de Castro, Jo-Anne A; Barez, Marie Yvette C; Frias, Melchor V; Dixit, Jitendra; Genereux, Maurice

    2007-04-01

    Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF). An immune mechanism of thrombocytopenia due to increased platelet destruction appears to be operative in patients with DHF (see Saito et al., 2004, Clin Exp Immunol 138: 299-303; Mitrakul, 1979, Am J Trop Med Hyg 26: 975-984; and Boonpucknavig, 1979, Am J Trop Med Hyg 28: 881-884). The interim data of two randomized placebo controlled trials in patients (N = 47) meeting WHO criteria for dengue hemorrhagic fever (DHF) with severe thrombocytopenia (platelets WinRho SDF), 50 microg/kg (250 IU/kg) intravenously is more brisk than the placebo group. The mean maximum platelet count of the anti-D-treated group at 48 hours was 91,500/mm(3) compared with 69,333/mm(3) in the placebo group. 75% of the anti-D-treated group demonstrated an increase of platelet counts > or = 20,000 compared with only 58% in the placebo group. These data suggest that treatment of severe thrombocytopenia accompanying DHF with anti-D may be a useful and safe therapeutic option. PMID:17426181

  6. Inhibition of phagocytic recognition of anti-D opsonized Rh D+ RBC by polymer-mediated immunocamouflage.

    Science.gov (United States)

    Li, Li; Noumsi, Ghislain T; Kwok, Yin Yu Eunice; Moulds, Joann M; Scott, Mark D

    2015-12-01

    The Rh D antigen posed both a significant clinical risk and inventory supply issue in transfusion medicine. The successful development of the immunocamouflaged RBC has the potential to address both the risk of acute anti-D transfusion reactions and to improve D- blood inventory in geographic locations where D- blood is rare (e.g., China). The immunocamouflage of RBC was mediated by the covalent grafting of methoxy(polyethylene glycol) to the cell membrane thereby obscuring the D protein from the immune system. To determine the potential efficacy of mPEG-D+ RBC in D- recipients, anti-D alloantibodies from previously alloimmunized individuals were utilized. The effects of polymer chain size (2-30 kDa) and grafting concentration (0-4 mM) on antibody binding and erythrophagocytosis were determined using the clinically validated monocyte monolayer assay (MMA) and flow cytometry. The immunocamouflage of D was polymer size and grafting concentration dependent as determined using human anti-D alloantibodies (both pooled [RhoGAM] and single donors). Importantly, the 20 kDa polymer provided excellent immunocamouflage of D and reached a clinically significant level of protection, as measured by the MMA, at grafting concentrations of ≥1.5 mM. These findings further support the potential use of immunocamouflaged RBC to reduce the risk of acute transfusion reactions following administration of D+ blood to D- recipients in situations where D- units are unavailable or supply is geographically constrained. PMID:26440218

  7. Division of Energy Biosciences annual report and summaries of FY 1996 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.

  8. Routine administration of Anti-D: the ethical case for offering pregnant women fetal RHD genotyping and a review of policy and practice

    OpenAIRE

    Kent, Julie; Farrell, Anne-Maree; Soothill, Peter

    2014-01-01

    Background Since its introduction in the 1960s Anti-D immunoglobulin (Anti-D Ig) has been highly successful in reducing the incidence of haemolytic disease of the fetus and newborn (HDFN) and achieving improvements to maternal and fetal health. It has protected women from other invasive interventions during pregnancy and prevented deaths and damage amongst newborns and is a technology which has been adopted worldwide. Currently about one third of pregnant women with the blood group Rhesus D (...

  9. Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group.

    LENUS (Irish Health Repository)

    Kenny-Walsh, E

    2012-02-03

    BACKGROUND AND METHODS: In February 1994, batches of anti-D immune globulin used in Ireland during 1977 and 1978 to prevent Rh isoimmunization were found to be contaminated with hepatitis C virus (HCV) from a single infected donor. In March 1994, a national screening program was initiated for all women who had received anti-D immune globulin between 1970 and 1994. Of the 62,667 women who had been screened when this study began, 704 (1.1 percent) had evidence of past or current HCV infection, and 390 of those 704 (55 percent) had positive tests for serum HCV RNA on reverse-transcription-polymerase-chain-reaction analysis. All 390 were offered a referral for clinical assessment and therapy. We evaluated 376 of these 390 women (96 percent); the other 14 were not seen at one of the designated treatment centers. RESULTS: The mean (+\\/-SD) age of the 376 women was 45+\\/-6 years at the time of screening. They had been infected with hepatitis C for about 17 years. A total of 304 women (81 percent) reported symptoms, most commonly fatigue (248 [66 percent]). Serum alanine aminotransferase concentrations were slightly elevated (40 to 99 U per liter) in 176 of 371 women (47 percent), and the concentrations were 100 U per liter or higher in 31 (8 percent). Liver biopsies showed inflammation in 356 of 363 women (98 percent); in most cases the inflammation was slight (41 percent) or moderate (52 percent). Although the biopsy samples from 186 of the 363 women (51 percent) showed evidence of fibrosis, only 7 women (2 percent) had probable or definite cirrhosis. Two of the seven reported excessive alcohol consumption. CONCLUSIONS: Most of the women with HCV infection 17 years after receiving HCV-contaminated anti-D immune globulin had evidence of slight or moderate hepatic inflammation on liver biopsy, about half had fibrosis, and 2 percent had probable or definite cirrhosis.

  10. Relating D0-anti-D0 Mixing and D0 -> l+l- with New Physics

    OpenAIRE

    Golowich, Eugene; Hewett, JoAnne; Pakvasa, Sandip; Petrov, Alexey A.

    2009-01-01

    We point out how, in certain models, the same combination of New Physics couplings occur in the amplitudes for both D0-anti-D0 mixing and the rare decays D0 -> l+l-. If the New Physics dominates and is responsible for the observed mixing, then a very simple correlation exists between the magnitudes of each; in fact the rates for the decay D0 -> l+l- are completely fixed by the mixing. Observation of D0 -> l+l- in excess of the Standard Model prediction could identify New Physics contributions...

  11. Extensive numerical study of a D-brane, anti-D-brane system in AdS 5 /CFT 4

    OpenAIRE

    Hegedűs, Árpád(MTA Lendület Holographic QFT Group, Wigner Research Centre, H-1525, Budapest 114, P.O.B. 49, Hungary)

    2015-01-01

    In this paper the hybrid-NLIE approach of [38] is extended to the ground state of a D-brane anti-D-brane system in AdS/CFT. The hybrid-NLIE equations presented in the paper are finite component alternatives of the previously proposed TBA equations and they admit an appropriate framework for the numerical investigation of the ground state of the problem. Straightforward numerical iterative methods fail to converge, thus new numerical methods are worked out to solve the equations. Our numerical...

  12. A case of autoimmune hemolytic anemia with anti-D specificity in a one-year-old

    OpenAIRE

    Bercovitz, Rachel S.; Macy, Margaret; Ambruso, Daniel R.

    2013-01-01

    While antibodies to antigens in the Rh group are common causes of warm autoimmune hemolytic anemia, specificity for only the D-antigen is rare in autoimmune hemolysis in pediatric patients. This case reports an anti-D associated with severe hemolytic anemia (Hb = 2.1 g/dL) in a previously healthy 14-month-old who presented with a three-day history of low-grade fevers and vomiting. Because of his severe anemia, on admission to the hospital he was found to have altered mental status, metabolic ...

  13. Assessment of collaboration and interoperability in an information management system to support bioscience research.

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L

    2009-01-01

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C(4)I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the "must have" attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation. PMID:20351900

  14. On the outside looking in: redefining the role of analytical chemistry in the biosciences.

    Science.gov (United States)

    Hare, Dominic J; New, Elizabeth J

    2016-07-12

    Biomedical research has moved on from the study of the structure of organs, cells and organelles. Today, the key questions that must be addressed to understand the body in health and disease are related to fundamental biochemistry: the distribution and speciation of chemicals, the regulation of chemical reactions, and the control of chemical environments. To see advances in this field, it is essential for analytical chemists to actively engage in this process, from beginning to end. In this Feature Article, we review the progress that has been made towards gaining an understanding of the chemistry of the body, while commenting on the intrinsic disconnect between new innovations in the field of analytical chemistry and practical application within the biosciences. We identify the challenges that prevent chemists from making a greater impact in this field, and highlight key steps for moving forward.

  15. Googling your genes: personal genomics and the discourse of citizen bioscience in the network age

    Directory of Open Access Journals (Sweden)

    Marina Levina

    2010-03-01

    Full Text Available In this essay, I argue that the rise of personal genomics is technologically, economically, and most importantly, discursively tied to the rise of network subjectivity, an imperative of which is an understanding of self as always already a subject in the network. I illustrate how personal genomics takes full advantage of social media technology and network subjectivity to advertise a new way of doing research that emphasizes collaboration between researchers and its members. Sharing one’s genetic information is considered to be an act of citizenship, precisely because it is good for the network. Here members are encouraged to think of themselves as dividuals, or nodes, in the network and their actions acquire value based on that imperative. Therefore, citizen bioscience is intricately tied, both in discourse and practices, to the growth of the network in the age of new media.

  16. Scientific Reports of Plasma Medicine and its Mechanism for Therapy in Plasma Bioscience Research Center

    Science.gov (United States)

    Choi, Eun Ha

    2015-09-01

    Scientific reports of plasma medicine and its basic mechanism for therapy will be introduced, especially, performed in Plasma Bioscience Research Center, Korea. We have investigated enhanced anticancer effect of monocytes and macrophages activated by nonthermal plasma which act as immune-modulator on these immune cells. Further, we investigated the action of the nanosecond pulsed plasma activated media (NPPAM) on the lung cancer cells and its DNA oxidation pathway. We observed OD induced apoptosis on melanocytes G361 cancer cells through DNA damage signaling cascade. We also studied DNA oxidation by extracting DNA from treated cancer cell and analyzed the effects of OD/OH/D2O2/H2O2 on protein modification and oxidation. Additionally, we attempted molecular docking approaches to check the action of D2O2 on the apoptosis related genes.

  17. On the outside looking in: redefining the role of analytical chemistry in the biosciences.

    Science.gov (United States)

    Hare, Dominic J; New, Elizabeth J

    2016-07-12

    Biomedical research has moved on from the study of the structure of organs, cells and organelles. Today, the key questions that must be addressed to understand the body in health and disease are related to fundamental biochemistry: the distribution and speciation of chemicals, the regulation of chemical reactions, and the control of chemical environments. To see advances in this field, it is essential for analytical chemists to actively engage in this process, from beginning to end. In this Feature Article, we review the progress that has been made towards gaining an understanding of the chemistry of the body, while commenting on the intrinsic disconnect between new innovations in the field of analytical chemistry and practical application within the biosciences. We identify the challenges that prevent chemists from making a greater impact in this field, and highlight key steps for moving forward. PMID:26898242

  18. Assessment of Collaboration and Interoperability in an Information Management System to Support Bioscience Research

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L.

    2009-01-01

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C4I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the “must have” attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation. PMID:20351900

  19. Assessment of collaboration and interoperability in an information management system to support bioscience research.

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L

    2009-11-14

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C(4)I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the "must have" attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation.

  20. Production of Doctorates in the Biosciences, 1975-1980: An Experimental Forecast. Higher Education Panel Reports, No. 34.

    Science.gov (United States)

    Atelsek, Frank J.; Gomberg, Irene L.

    A survey was undertaken in 1976 to obtain short-term estimates of doctorate production directly from the heads of the science departments involved. These biosciences departments were surveyed in the 235 member institutions of the Higher Education Panel that grant doctorates: anatomy, biochemistry, biology, biometry/biostatistics/biomathematics,…

  1. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences

    Science.gov (United States)

    King, Nicola C.; Aves, Stephen J.

    2012-01-01

    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  2. States of ρ D{sup *} anti D{sup *} with J = 3 within the fixed center approximation to the Faddeev equations

    Energy Technology Data Exchange (ETDEWEB)

    Bayar, M. [Kocaeli University, Department of Physics, Izmit (Turkey); Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Ren, Xiu-Lei [Beihang University, School of Physics and Nuclear Energy Engineering and International Research Center for Nuclei and Particles in the Cosmos, Beijing (China); Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Oset, E. [Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain)

    2015-05-15

    We study the interaction of ρ, D* and anti D* with spins aligned using the fixed center approximation to the Faddeev equations. We select a cluster of D{sup *} anti D{sup *}, which is found to be bound in I = 0 and can be associated to the X(3915), and let the ρ meson orbit around the D* and anti D*. In this case we find an I = 1 state with mass around 4340 MeV and narrow width of about 50 MeV. We also investigate the case with a cluster of ρD* and let the anti D* orbit around the system of the two states. The ρD* cluster is also found to bind and leads to the D{sub 2}{sup *} state. The addition of the extra anti D* produces further binding and we find, with admitted uncertainties, a state of I = 0 around 4000 MeV, and a less bound narrow state with I = 1 around 4200 MeV. (orig.)

  3. Prediction of a Z{sub c}(4000) D* anti D* state and relationship with the claimed Z{sub c}(4025)

    Energy Technology Data Exchange (ETDEWEB)

    Aceti, F.; Oset, E. [Universidad de Valencia y IFIC, Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica, Valencia (Spain); Bayar, M. [Universidad de Valencia y IFIC, Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica, Valencia (Spain); Kocaeli University, Department of Physics, Izmit (Turkey); Dias, J.M. [Universidad de Valencia y IFIC, Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica, Valencia (Spain); Universidade de Sao Paulo, Instituto de Fisica (Brazil)

    2014-06-15

    After discussing the OZI suppression of one light meson exchange in the interaction of D* anti D* with isospin I = 1, we study the contribution of the two-pion exchange to the interaction and the exchange of heavy vectors, J/ψ for diagonal transitions D* anti D* and D* for transitions of D* anti D* to J/ψ ρ. We find these latter mechanisms to be weak, but enough to barely bind the system in J = 2 with a mass around 4000 MeV, while the effect of the two-pion exchange is a net attraction, though weaker than that from heavy-vector exchange. We discuss this state and try to relate it to the Z{sub c} (4025) state, above the D* anti D threshold, claimed in an experiment at BES from an enhancement of the D* anti D* distribution close to threshold. Together with the results from a recent reanalysis of the BES experiment showing that it is compatible with a J = 2 state below threshold around 3990 MeV, we conclude that the BES experiment could show the existence of the state that we find in our approach. (orig.)

  4. A search for neutral D meson - anti-D meson mixing in semileptonic decays from FOCUS

    Science.gov (United States)

    Hosack, Michael Galen

    Leading order perturbative calculations indicate D0--D¯0 mixing at 10-10--10-9 levels in the Standard Model. This is far below present experimental sensitivities. Observation of D0--D¯ 0 mixing would indicate either new physics or the presence of large long distance contributions. This thesis reports on a search for D0--D¯0 mixing in semileptonic decays from the FOCUS (E831) photoproduction experiment. Data from FOCUS were taken during the 1996--1997 fixed target run at Fermi National Accelerator Laboratory. The measured mixing fraction is rmix = ( -7.5+9.9,+2.1-9.3,-2.6 ) x 10-4, where the first errors are statistical and the second errors are systematic. This result is consistent with no mixing and corresponds to a 95% confidence level upper limit of r mix < 13.1 x 10-4. This is presently the world's most sensitive limit on rmix.

  5. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab (MHB)

  6. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    International Nuclear Information System (INIS)

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab

  7. Padronização do Uso de Imunoglobulina Anti-D na Profilaxia da Isoimunização Rh

    OpenAIRE

    L. Vicente; Pinto, MG; Serrano, MF; Soares, C.; Alegria, A.

    2000-01-01

    A isoimunização RhD durante a gravidez tem graves repercussões fetais e neonatais. Apesar da imunoprofilaxia com imunoglobulina anti-D ter diminuído drasticamente a mortalidade e morbilidade perinatais, continuam a existir casos de isoimunização que se devem a uma administração inadequada. No âmbito de um projecto de padronização da administração de imunoglobulina anti-D, foram levados a cabo um inquérito aos obstetras da MAC e uma análise retrospectiva de processos de mulheres RhD negativas....

  8. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  9. Challenges and opportunities for early-career Teaching-Focussed academics in the biosciences [v2; ref status: indexed, http://f1000r.es/5c2

    Directory of Open Access Journals (Sweden)

    Katharine Hubbard

    2015-04-01

    Full Text Available Twenty-seven percent of academics in UK Higher Education (HE are in Teaching-Focussed positions, making major contributions to undergraduate programmes in an era of high student expectations when it comes to teaching quality. However, institutional support for Teaching-Focussed academics is often limited, both in terms of peer networking and opportunities for career development. As four early-career stage Teaching-Focussed academics working in a variety of institutions, we explore what motivated our choices to make teaching our primary academic activity, and the challenges that we have faced in doing so. In addition to highlighting the need for universities to fully recognise the achievements of teaching staff, we discuss the role that the various biosciences learned societies have in supporting Teaching-Focussed academics. We identify that there is a need for the learned societies to come together and pool their expertise in this area. The fragmented nature of the Teaching-Focussed academic community means that clear sources of national support are needed in order to best enable the next generation of bioscience educators to reach their full potential.

  10. Clearance of red cells by monoclonal IgG3 anti-D in vivo is affected by the VF polymorphism of Fc gamma RIIIa (CD16)

    NARCIS (Netherlands)

    Kumpel, BM; De Haas, M; Koene, HR; Van de Winkel, JGJ; Goodrick, MJ

    2003-01-01

    Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro , and may alter the efficiency of clearance of immune complexes in vivo. In

  11. Evaluation of the effects of and earliest response rate to anti-D treatment in children with chronic idiopathic thrombocytopenic purpura: a pilot study.

    Science.gov (United States)

    Yetgin, Sevgi; Aytaç, Selin; Olcay, Lale; Tunç, Bahattin; Ozbek, Namik; Aydinok, Yeşim

    2010-01-01

    In this pilot study, 30 (14 male, 16 female; median age: 8 years, range: 2-18) chronic non-splenectomized idiopathic thrombocytopenic purpura (ITP) patients with Rh+ blood group and their 49 attacks were evaluated after intravenous (i.v.) anti-D (WinRho SDF, Cangene Corporation, Winnipeg, MB, Canada) treatment at a dose of 50 microg/kg x 3 days (n = 21 cases; 35 attacks) or a single dose of 75 microg/kg (n = 9 cases; 14 attacks) to define the hemostatic dose of anti-D. Five of 30 patients (22/49 attacks) were resistant to steroid, intravenous immunoglobulin (IVIG) and vincristine treatment. Hemoglobin (Hb), white blood cells (WBC), platelets (plt) and reticulocytes (ret) were evaluated before and after treatment during the follow-up in sequences on the 1st, 7th, 14th and 21st days after anti-D treatment if the patients had no symptom. All patients, even the resistant ones, experienced an increase in plt count to provide protection from bleeding (> or = 20 x 10(9)/L in patients with symptoms, > or = 10 x 10(9)/L in patients without symptoms). The plt responses of one resistant and five non-resistant patients treated with a single 75 microg/kg dose of i.v. anti-D in 8 attacks were monitored at the 2nd, 4th, 8th, 24th and 48th hours of the treatment. A protective plt level was attained within 2 hours in 6 attacks of five non-resistant cases and in 24 hours in the remaining 2 attacks of one resistant case. This pilot study suggests that anti-D treatment in ITP patients is effective and can increase plt to a level adequate enough to protect from hemorrhage within 2 hours, when given in a 75 microg/kg dose. A few adverse events (i.e. chills, hemolysis and hemoglobinuria) resolved without intervention. PMID:20560246

  12. [Effect of erythrocyte preserved for different lengths of time on anti-D antibody identification with three blood matching tests].

    Science.gov (United States)

    Xiao, Rui-Qing; Lin, Wu-Cun; Xu, Dan; Zeng, Jie; Wu, Jian-Jun; Zhao, Shu-Ming

    2003-10-01

    The specificity of the antigens and length of preservation time of erythrocytes are the interfering factors in blood group serological tests. In order to clarify the influence of preservation time of erythrocytes on the blood matching test, the titers of anti-D antibody were detected with papain method, BioVue cross matching card and DianaGel cross matching card in 7 series of panel red blood cells preserved for various length of time (0 to 9 months). The results showed that the titer of micro-column gel test (DianaGel card) was one tube higher than that of column agglutinating test (BioVue card). The titer of erythrocytes preserved for 9 months was as high as 256 tested by DianaGel card, but it was only 2 by papain method in the same anti-serum. It is suggested that there was no obvious difference between the results of micro-column gel test and column agglutinating test, and titer of papain method was the lowest. PMID:14575550

  13. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends; SBBN 2010: 7. Congresso da Sociedade Brasileira de Biociencias Nucleares. Radiacoes em biociencias: avancos e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  14. A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

    Directory of Open Access Journals (Sweden)

    Quail Michael A

    2012-07-01

    Full Text Available Abstract Background Next generation sequencing (NGS technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’ RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. Results Sequence generated by Ion Torrent, MiSeq and Pacific Biosciences technologies displays near perfect coverage behaviour on GC-rich, neutral and moderately AT-rich genomes, but a profound bias was observed upon sequencing the extremely AT-rich genome of Plasmodium falciparum on the PGM, resulting in no coverage for approximately 30% of the genome. We analysed the ability to call variants from each platform and found that we could call slightly more variants from Ion Torrent data compared to MiSeq data, but at the expense of a higher false positive rate. Variant calling from Pacific Biosciences data was possible but higher coverage depth was required. Context specific errors were observed in both PGM and MiSeq data, but not in that from the Pacific Biosciences platform. Conclusions All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support.

  15. Avaliação de reagentes anti-D na detecção dos antígenos D fraco e D parcial Evaluation of anti-D reagents in the detection of weak D and partial D antigens

    OpenAIRE

    Clayton Barros; Márcia Otta; Valeria L. Wakim; Márcia Zaqueroni; Wilson Baleotti Júnior; Lilian Castilho

    2006-01-01

    Anti-soros monoclonais anti-D IgG e IgM têm sido produzidos para substituir os policlonais na determinação do antígeno D. No entanto, pouco se conhece a respeito da utilização destes reagentes na detecção dos antígenos RhD fraco e RhD parcial. Estudos moleculares e sorológicos que possam esclarecer a expressão do antígeno D são importantes para a seleção adequada dos reagentes anti-D utilizados na fenotipagem RhD. Foram analisados anti-soros anti-D monoclonais IgG e IgM quanto à capacidade de...

  16. Efficacy, safety, and dose response of intravenous anti-D immune globulin (WinRho SDF) for the treatment of idiopathic thrombocytopenic purpura in children.

    Science.gov (United States)

    Freiberg, A; Mauger, D

    1998-01-01

    We analyzed data from 20 children treated for acute or chronic idiopathic (immune) thrombocytopenic purpura (ITP) at a single institution to determine the relationship between dose of intravenous anti-D immune globulin (WinRho SDF; Nabi, Boca Raton, FL), increase in platelet count, and decrease in hemoglobin in the therapy of ITP. Higher doses of anti-D were clearly associated with a greater therapeutic response in the platelet count, with no increase in hemolysis for both acute and chronic ITP. A significant correlation was found between dose and peak increase in platelet count measured in the 14 days following administration. This effect was present for both acute ITP (17 infusions, P = .0001) and chronic ITP (30 infusions, P = .038). Although hemolysis was seen in nearly all infusions, with a median hemoglobin fall of 1.9 g/dL (range, 0 to 4.2), the decrease in hemoglobin was greater than 2.5 for only three infusions, and the largest fall in hemoglobin (4.2) was in a child with an underlying hemolytic anemia. Furthermore, for both acute and chronic ITP there was no relationship between the decrease in hemoglobin and the dose given (P = .22), nor between the increase in platelet count and fall in hemoglobin (P = .27). This analysis supports the use of higher doses of anti-D for the treatment of ITP, and demonstrates the need for a trial of high-dose anti-D (>100 microg/kg) in acute and chronic ITP. PMID:9523746

  17. Antibody-dependent cell-mediated cytotoxicity (ADCC) toward human O+ red cells coated with anti-D antibody: comparison between lymphocyte and monocyte ADCC activity.

    OpenAIRE

    Sunada,Mitsutoshi; Suzuki, Shinya; Ota, Zensuke

    1985-01-01

    We investigated the antibody dependent cell-mediated cytotoxicity (ADCC) of lymphocytes and monocytes toward human O+ red cells coated with anti-D antibody using a 51Cr release assay. Lysis of sensitized red cells by lymphocytes occurred rapidly, but monocyte-mediated lysis occurred slowly. This difference might be due to postphagocytic 51Cr release by monocytes. ADCC of lymphocytes increased in proportion to the effector cell number, but large amounts of antibodies were required. In contrast...

  18. Routine antenatal anti-D prophylaxis in women who are Rh(D negative: meta-analyses adjusted for differences in study design and quality.

    Directory of Open Access Journals (Sweden)

    Rebecca M Turner

    Full Text Available BACKGROUND: To estimate the effectiveness of routine antenatal anti-D prophylaxis for preventing sensitisation in pregnant Rhesus negative women, and to explore whether this depends on the treatment regimen adopted. METHODS: Ten studies identified in a previous systematic literature search were included. Potential sources of bias were systematically identified using bias checklists, and their impact and uncertainty were quantified using expert opinion. Study results were adjusted for biases and combined, first in a random-effects meta-analysis and then in a random-effects meta-regression analysis. RESULTS: In a conventional meta-analysis, the pooled odds ratio for sensitisation was estimated as 0.25 (95% CI 0.18, 0.36, comparing routine antenatal anti-D prophylaxis to control, with some heterogeneity (I²  =  19%. However, this naïve analysis ignores substantial differences in study quality and design. After adjusting for these, the pooled odds ratio for sensitisation was estimated as 0.31 (95% CI 0.17, 0.56, with no evidence of heterogeneity (I²  =  0%. A meta-regression analysis was performed, which used the data available from the ten anti-D prophylaxis studies to inform us about the relative effectiveness of three licensed treatments. This gave an 83% probability that a dose of 1250 IU at 28 and 34 weeks is most effective and a 76% probability that a single dose of 1500 IU at 28-30 weeks is least effective. CONCLUSION: There is strong evidence for the effectiveness of routine antenatal anti-D prophylaxis for prevention of sensitisation, in support of the policy of offering routine prophylaxis to all non-sensitised pregnant Rhesus negative women. All three licensed dose regimens are expected to be effective.

  19. Bioculture System: Expanding ISS Space Bioscience Capabilities for Fundamental Stem Cell Research and Commercial Applications

    Science.gov (United States)

    Blaber, Elizabeth; Dvorochkin, Natalya; Almeida, Eduardo; Fitzpatrick, Garret; Ellingson, Lance; Mitchell, Sarah; Yang, Anthony; Kosnik, Cristine; Rayl, Nicole; Cannon, Tom; Austin, Edward; Sato, Kevin

    With the recent call by the 2011 Decadal Report and the 2010 Space Biosciences Roadmap for the International Space Station (ISS) to be used as a National Laboratory for scientific research, there is now a need for new laboratory instruments on ISS to enable such research to occur. The Bioculture System supports the extended culturing of multiple cell types and microbiological specimens. It consists of a docking station that carries ten independent incubation units or ‘Cassettes’. Each Cassette contains a cooling chamber (5(°) C) for temperature sensitive solutions and samples, or long duration fluids and sample storage, as well as an incubation chamber (ambient up to 42(°) C). Each Cassette houses an independent fluidics system comprised of a biochamber, medical-grade fluid tubing, medium warming module, oxygenation module, fluid pump, and sixteen solenoid valves for automated biochamber injections of sampling. The Bioculture System provides the user with the ability to select the incubation temperature, fluid flow rate and automated biochamber sampling or injection events for each separate Cassette. Furthermore, the ISS crew can access the biochamber, media bag, and accessory bags on-orbit using the Microgravity Science Glovebox. The Bioculture System also permits initiation of cultures, subculturing, injection of compounds, and removal of samples for on-orbit processing using ISS facilities. The Bioculture System therefore provides a unique opportunity for the study of stem cells and other cell types in space. The first validation flight of the Bioculture System will be conducted on SpaceX5, consisting of 8 Cassettes and lasting for 30-37 days. During this flight we plan to culture two different mammalian cell types in bioreactors: a mouse osteocytic-like cell line, and human induced pluripotent stem cell (iPS)-derived cardiomyocytes. Specifically, the osteocytic line will enable the study of a type of cell that has been flown on the Bioculture System

  20. [A RhD negative patient failed to produce detectable anti-D after transfusion of 35 units of RhD positive red blood cells].

    Science.gov (United States)

    Lee, Won Mok; Kim, Ji Hae; Ha, Jung Sook; Ryoo, Nam Hee; Jeon, Dong Seok; Kim, Jae Ryong; Cho, Duck

    2007-10-01

    In the present day, pretransfusion tests include ABO and RhD grouping, antibody screening, antibody identification, and cross matching. Although error rates for these tests have decreased compared to those in the past, clerical errors still occur. When exposed to RhD positive RBCs, a RhD negative person can produce anti-D that causes a severe hemolytic disease of the fetus and the newborn in addition to hemolytic transfusion reactions. Therefore, administration of RhD positive RBCs to a RhD negative person should be avoided. We experienced a RhD negative patient who had been misidentified as positive and transfused 35 units of RhD positive RBCs eight years ago, but did not have detectable anti-D in present. The red cells of the patient showed no agglutination with the anti-D reagent and a negative result in the standard weak D test. The multiplex PCR with sequence-specific priming revealed that the patient was RhD negative. PMID:18094603

  1. Anti-D (WinRho SD) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production.

    Science.gov (United States)

    Semple, J W; Allen, D; Rutherford, M; Woloski, M; David, M; Wakefield, C; Butchart, S; Freedman, J; Blanchette, V

    2002-03-01

    Intravenous anti-D is often used in the treatment of autoimmune thrombocytopenic purpura (AITP), but little is known about its mechanisms of action. To investigate anti-D's potential in vivo mechanism(s) of action, a small group (N = 7) of children with chronic AITP was studied. The children initially received either 25 or 50 microg/kg of WinRho-SD in a four-cycle cross-over trial, and peripheral blood samples from the first and third cycles were assessed for cytokine levels at pre-treatment, 3 hr, 1 day, and 8 days post-treatment. Results showed that platelet counts significantly increased in all the children by day 8 post-treatment. Analysis of serum by ELISA showed that there was a significant but transient rise in both pro- and anti-inflammatory cytokine/chemokine levels (e.g., IL1RA, IL6, GM-CSF, MCP-1 alpha, TNF-alpha and MCP-1) by 3 hr post-treatment in both cycles which returned to baseline levels by 8 days post-treatment. These results suggest that anti-D administration may initially activate the RES in the form of cytokine/chemokine secretion, which is subsequently followed by an increase in platelet counts. It is possible that the induced cytokine/chemokine storm may have an effect on several physiological processes such as those mediating either adverse effects or potentially RES phagocytic activity. PMID:11891813

  2. Immunogenic and antigenic epitopes of immunoglobulins binding of human monoclonal anti-D antibodies to FcRI on the monocyte-like U937 cell line.

    Science.gov (United States)

    Walker, M R; Kumpel, B M; Thompson, K; Woof, J M; Burton, D R; Jefferis, R

    1988-01-01

    Seventeen human monoclonal IgG1- or IgG3 anti-D-secreting clones have been examined for their ability to sensitise O+ red cells for Fc-receptor-mediated rosette formation with U937 cells. IgG3 but not IgG1 anti-D antibodies were able to mediate stable rosette formation with unstimulated U937 cells via interaction with the FcRI receptor. Decreasing FcRI density by incubating U937 cells with di-butyryl cAMP almost completely abolished rosette formation, whilst increasing FcRI density by incubating U937 cells with interferon-gamma increased the percentage of cells forming rosettes with IgG3- and IgG1-sensitised red cells. These data suggest that rosette formation between IgG anti-D-sensitised red cells and FcRI-expressing cells is dependent upon the density of IgG3 on the red cell surface, the density of FcRI on the effector cell, multiple FcRI/IgG interactions are required for stable rosette formation and that more FcRI/IgG1 than FcRI/IgG3 interactions are required. PMID:2464239

  3. Targeted routine antenatal anti-D prophylaxis in the prevention of RhD immunisation--outcome of a new antenatal screening and prevention program.

    Directory of Open Access Journals (Sweden)

    Eleonor Tiblad

    Full Text Available OBJECTIVE: To estimate the incidence of RhD immunisation after implementation of first trimester non-invasive fetal RHD screening to select only RhD negative women carrying RHD positive fetuses for routine antenatal anti-D prophylaxis (RAADP. MATERIALS AND METHODS: We present a population-based prospective observational cohort study with historic controls including all maternity care centres and delivery hospitals in the Stockholm region, Sweden. All RhD negative pregnant women were screened for fetal RHD genotype in the first trimester of pregnancy. Anti-D immunoglobulin (250-300 µg was administered intramuscularly in gestational week 28-30 to participants with RHD positive fetuses. Main outcome measure was the incidence of RhD immunisation developing during or after pregnancy. RESULTS: During the study period 9380 RhD negative women gave birth in Stockholm. Non-invasive fetal RHD genotyping using cell-free fetal DNA in maternal plasma was performed in 8374 pregnancies of which 5104 (61% were RHD positive and 3270 (39% RHD negative. In 4590 pregnancies with an RHD positive test the women received antenatal anti-D prophylaxis. The incidence of RhD immunisation in the study cohort was 0.26 percent (24/9380 (95% CI 0.15-0.36% compared to 0.46 percent (86/18546 (95% CI 0.37 to 0.56% in the reference cohort. The risk ratio (RR for sensitisation was 0.55 (95% CI 0.35 to 0.87 and the risk reduction was statistically significant (p = 0.009. The absolute risk difference was 0.20 percent, corresponding to a number needed to treat (NNT of 500. CONCLUSIONS: Using first trimester non-invasive antenatal screening for fetal RHD to target routine antenatal anti-D prophylaxis selectively to RhD negative women with RHD positive fetuses significantly reduces the incidence of new RhD immunisation. The risk reduction is comparable to that reported in studies evaluating the outcome of non selective RAADP to all RhD negative women. The cost-effectiveness of this

  4. Search for D0--anti-D0 Mixing and Branching-Ratio Measurement in the Decay D0 --> K+ pi- pi0

    CERN Document Server

    Aubert, B; Bóna, M; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Gill, M S; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Del Amo-Sánchez, P; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Sherwood, D J; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Best, D S; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dvoretskii, A; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Petzold, A; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, E; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Behera, P K; Chai, X; Charles, M J; Mallik, U; Meyer, N T; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gritsan, A V; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Wren, A C; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Cowan, R; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Paolucci, P; Piccolo, D; Sciacca, C; Baak, M; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Rahimi, A M; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; Briand, H; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Ebert, M; Schröder, H; Waldi, R; Adye, T; De, N; Groot; Franek, B; Olaiya, E O; Wilson, F F; Aleksan, R; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Vasseur, G; Yéche, C; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Lanceri, L; Vitale, L; Azzolini, V; Martínez-Vidal, F; Banerjee, Sw; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Pappagallo, M; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Flood, K T; Hollar, J J; Kutter, P E; Mellado, B; Mihályi, A; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We present a search for D0--anti-D0 mixing using regions of phase space in which the rate of doubly Cabibbo-suppressed decays D0 --> K+ pi- pi0 relative to Cabibbo-favored decays D0 --> K- pi+ pi0 is reduced. We analyze 230.4 fb-1 of data collected with the BaBar detector at the PEP-II e+ e- collider at SLAC. We present results with and without the assumption of CP conservation. Assuming CP conservation, we measure the time-integrated mixing rate R_M = (0.023 +0.018/-0.014(stat.) +/- 0.004(syst.))%, and R_M K+ pi- pi0 relative to D0 --> K- pi+ pi0 to be (0.214 +/- 0.008(stat.) +/- 0.008(syst.))%.

  5. Estimation of anti-D IgG in red blood cell eluates using the specific radioactivity of 125I-labeled IgG: effect of unlabeled, cytophilic IgG

    Energy Technology Data Exchange (ETDEWEB)

    Masouredis, S.P.; Mahan, L.C.; Sudora, E.J.; Langley, J.W.; Victoria, E.J.

    1981-01-01

    The specific radioactivity of conventionally prepared 125I IgG anti-D eluates is significantly less (from 1/5 to 1/20) than that of the 125I IgG fraction used to prepare the eluate. This discrepancy is due to the release of unlabeled, cytophilic IgG from normal red blood cells during eluate preparation and does not represent an underestimation of the eluate anti-D IgG content. Cytophilic IgG content of eluates plays an important role in reducing the nonimmunologic binding of labeled antibody IgG. The results justify the assumption used in numerous studies that the specific radioactivity of 125I IgG fractions can be used to provide a valid estimate of the anti-D IgG content of eluates.

  6. Avaliação da hemorragia feto-materna em puérperas com indicação para ministração de imunoglobulina anti-D Evaluation of fetomaternal hemorrhage in postpartum patients with indication for administration of anti-D immunoglobulin

    Directory of Open Access Journals (Sweden)

    Eduardo Baiochi

    2005-10-01

    Full Text Available Avaliamos a ocorrência da hemorragia feto-materna entre 343 puérperas que receberiam profilaxia da aloimunização Rh com emprego de imunoglobulina anti-D. Realizamos o teste de roseta para triagem dos casos que necessitariam determinação quantitativa do volume de sangue fetal transferido para circulação materna, que foi então apurado pelo teste de Kleihauer-Betke (K-B. O teste de roseta apresentou resultado positivo em 22 casos (6,4%. Em cinco dessas amostras o teste de K-B não apontou hemorragia feto-materna (falso positivo do teste de roseta de 1,45% e noutra a leitura do teste não foi conclusiva. Tivemos oito casos com volume apurado de hemorragia feto-materna This study evaluated fetomaternal hemorrhage (FMH in 343 postpartum patients who required prophylaxis of Rh alloimmunization with anti-D immunoglobulin. The rosette test was applied to screen for patients needing quantitative determination of fetal blood transferred from the maternal circulation, which was then measured by the Kleihauer-Betke test (K-B. The rosette test was positive in 22 cases (6.4%. In five of these cases, K-B did not show fetomaternal hemorrhage (a 1.45% false-positive rate for the rosette test, and in one case the test was inconclusive. There were 8 cases with FMH 30ml (0.58%, requiring a supplementary dose of anti-D. The study concludes that following the rosette test, additional evaluation of FMH using a quantitative test was unnecessary in 93.6% of the cases.

  7. Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements.

    Science.gov (United States)

    McRae, Michael P; Simmons, Glennon W; Wong, Jorge; Shadfan, Basil; Gopalkrishnan, Sanjiv; Christodoulides, Nicolaos; McDevitt, John T

    2015-10-21

    The development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system.

  8. Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements.

    Science.gov (United States)

    McRae, Michael P; Simmons, Glennon W; Wong, Jorge; Shadfan, Basil; Gopalkrishnan, Sanjiv; Christodoulides, Nicolaos; McDevitt, John T

    2015-10-21

    The development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system. PMID:26308851

  9. Searches for Direct CP Violation in D+ Decays And for D0 Anti-D0 Mixing

    Energy Technology Data Exchange (ETDEWEB)

    Purohit, M.V.; /South Carolina U.

    2005-10-11

    The authors present preliminary results of a search for direct CP violation in D{sup +} {yields} K{sup +}K{sup -} {pi}{sup +} decays using 87 fb{sup -1} of data acquired by the Babar experiment running on and near the {Upsilon}(4S) from 1999-2002. The authors report the asymmetries in the signal mode and in the main resonant subchannels. Based on the same dataset, they also report a new 90% CL upper limit of 0.0042 on the rate of D{sup 0}-{bar D}{sup 0} mixing using the decay modes D*{sup +} {yields} D{sup 0}{pi}{sup +}, D{sup 0} {yields} [K/K*]ev (+c.c.).

  10. Search for D0--anti-D0 Mixing in the Decays D0 --> K+ pi- pi+ pi-

    Energy Technology Data Exchange (ETDEWEB)

    Aubert, B.

    2006-09-26

    We present a search for D{sup 0}-{bar D}{sup 0} mixing in the decays D{sup 0} {yields} K{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -} using 230.4 fb{sup -1} of data collected with the BABAR detector at the PEP-II e{sup +}e{sup -} collider at SLAC. Assuming CP conservation, we measure the time-integrated mixing rate R{sub M} = (0.019{sub -0.015}{sup +0.016}(stat.) {+-} 0.002(syst.))%, and R{sub M} < 0.048% at the 95% confidence level. Using a frequentist method, we estimate that the data are consistent with no mixing at the 4.3% confidence level. We present results both with and without the assumption of CP conservation. By combining the value of R{sub M} from this analysis with that obtained from an analysis of the decays D{sup 0} {yields} K{sup +}{pi}{sup -}{pi}{sup 0}, we find R{sub M} = (0.020{sub -0.010}{sup +0.011})%, where the uncertainty is statistical only. We determine the upper limit R{sub M} < 0.042% at the 95% confidence level, and we find the combined data are consistent with the no-mixing hypothesis at the 2.1% confidence level.

  11. A new fetal RHD genotyping test: Costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales

    Directory of Open Access Journals (Sweden)

    Osipenko Leeza

    2011-01-01

    Full Text Available Abstract Background Postnatal and antenatal anti-D prophylaxis have dramatically reduced maternal sensitisations and cases of rhesus disease in babies born to women with RhD negative blood group. Recent scientific advances mean that non-invasive prenatal diagnosis (NIPD, based on the presence of cell-free fetal DNA in maternal plasma, could be used to target prophylaxis on "at risk" pregnancies where the fetus is RhD positive. This paper provides the first assessment of cost-effectiveness of NIPD-targeted prophylaxis compared to current policies. Methods We conducted an economic analysis of NIPD implementation in England and Wales. Two scenarios were considered. Scenario 1 assumed that NIPD will be only used to target antenatal prophylaxis with serology tests continuing to direct post-delivery prophylaxis. In Scenario 2, NIPD would also displace postnatal serology testing if an RhD negative fetus was identified. Costs were estimated from the provider's perspective for both scenarios together with a threshold royalty fee per test. Incremental costs were compared with clinical implications. Results The basic cost of an NIPD in-house test is £16.25 per sample (excluding royalty fee. The two-dose antenatal prophylaxis policy recommended by NICE is estimated to cost the NHS £3.37 million each year. The estimated threshold royalty fee is £2.18 and £8.83 for Scenarios 1 and 2 respectively. At a £2.00 royalty fee, mass NIPD testing would produce no saving for Scenario 1 and £507,154 per annum for Scenario 2. Incremental cost-effectiveness analysis indicates that, at a test sensitivity of 99.7% and this royalty fee, NIPD testing in Scenario 2 will generate one additional sensitisation for every £9,190 saved. If a single-dose prophylaxis policy were implemented nationally, as recently recommended by NICE, Scenario 2 savings would fall. Conclusions Currently, NIPD testing to target anti-D prophylaxis is unlikely to be sufficiently cost-effective to

  12. Tutorials in mathematical biosciences

    CERN Document Server

    2008-01-01

    The book offers an easy introduction to fast growing research areas in evolution of species, population genetics, ecological models, and population dynamics. The first two chapters review the concept and methodologies of phylogenetic trees; computational schemes and illustrations are given, including applications such as tracing the origin of SARS and influenza. The third chapter introduces the reader to ecological models, including predator-prey models. This chapter includes and introduction to reaction-diffusion equations, which are used to analyze the ecological models. The next chapter reviews a broad range of ongoing research in population dynamics, including evolution of dispersal models; it also features interesting mathematical theorems and lists open problems. The final chapter deals with gene frequencies under the action of migration and selection. The book is addressed to readers at the level of grad students and researchers. A background in PDEs is provided.

  13. 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.

    Science.gov (United States)

    Nelson, Christopher J; Ausió, Juan

    2012-06-01

    The 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability in Whistler, Canada, 14-18 March 2012, brought together 31 speakers from different nationalities. The organizing committee, led by Jim Davie (Chair) at the University of Manitoba (Manitoba, Canada), consisted of several established researchers in the fields of chromatin and epigenetics from across Canada. The meeting was centered on the contribution of epigenetics to gene expression, DNA damage and repair, and the role of environmental factors. A few interesting talks on replication added some insightful information on the controversial issue of histone post-translational modifications as genuine epigenetic marks that are inherited through cell division.

  14. A case of high-titer anti-D hemolytic disease of the newborn in which late onset and mild course is associated with the D variant, RHD-CE(9)-D

    DEFF Research Database (Denmark)

    Jakobsen, Marianne A; Nielsen, Christian; Sprogøe, Ulrik

    2014-01-01

    BACKGROUND: The RhD antigen is very immunogenic and is a significant cause of hemolytic disease of the newborn (HDN). The RHD-CE(8-9)-D hybrid allele is commonly associated with a D- phenotype. Here, we report a case of high-titer maternal anti-D and late onset of HDN in a newborn carrying a RHD...... and his father. CONCLUSION: Individuals carrying the RHD-CE(9)-D allele do express D antigen, but do so at significantly lower levels than those carrying the more common D+ phenotypes (e.g., DCe/dce). It may mitigate and delay otherwise severe HDN in pregnancies complicated by high-titer anti-D....

  15. Development of a dedicated beam forming system for material and bioscience research with high intensity, small field electron beam of LILLYPUT 3 accelerator at Wroclaw Technology Park

    CERN Document Server

    Adrich, Przemysław; Wilk, Piotr; Chorowski, Maciej; Poliński, Jarosław; Bogdan, Piotr

    2016-01-01

    The primary use of the LILLYPUT 3 accelerator at the Nondestructive Testing Laboratory at Wroclaw Technology Park is X-ray radiography for nondestructive testing, including R&D of novel techniques for industrial and medical imaging. The scope of possible applications could be greatly extended by providing a system for irradiation with electron beam. The purpose of this work was to design such a system, especially for high dose rate, small field irradiations under cryogenic conditions for material and bioscience research. In this work, two possible solutions, based either on beam scanning or scattering and collimation, were studied and compared. It was found that under existing conditions efficiency of both systems would be comparable. The latter one was adopted due to its simplicity and much lower cost. The system design was optimized by means of detailed Monte Carlo modeling. The system is being currently fabricated at National Centre for Nuclear Research in \\'Swierk.

  16. Implementation of ML Using Naïve Bayes Algorithm for Identifying Disease-Treatment Relation in Bio-Science Text

    Directory of Open Access Journals (Sweden)

    T.F. Michael Raj

    2013-01-01

    Full Text Available In recent years many successful machine learning applications have been developed, ranging from datamining programs to information-filtering systems that learn users' reading preferences. At the same time, there have been important advances in the theory and algorithms that can be used identify the diseases and treatment relations in a Bio-Science text. Imagine a computer learns from medical records which treatments are most effective for new diseases. Having the machine learning concept behind we have proposed a Machine Learning (ML approach based on Naïve Bayes (NB algorithm to improve the automatic disease identification in the medical field. And also we have improved text classification by using an integrated model.

  17. Rh(D)阴性孕妇血清抗-D水平检测意义%Significance of detection the anti-D level of Rh(D)-negative pregnant women

    Institute of Scientific and Technical Information of China (English)

    黄颖; 林甲进; 施顺秋; 裘晓乐

    2012-01-01

    Objective: To comprehend the correlation between anti - D level of Rh ( D) - negative pregnant women and baby prognostic. Methods; The clinical data of 194 Rh (D) - negative pregnant women during 2004.1 to 2010. 12 was analyzed including gestation, delivery and their anti - D level. Results; Among 194 pregnant women of Rh (D) negative 19 cases show anti - D, antibody level of IgG from 1:2-1: 2048, there are 9 pregnant women with two and less pregnancy whose, antibody level of IgG from 1: 2-l: 128, there are 7 cases with three and more pregnancy whose antibody level of IgG from 1: 128 - 1: 2048. (Three pregnant women haven't given birth in our hospital are not conclued). One case of them produced anti - D who are the 1 gestation and once transfusional. Conclusion; Detecting anti - D level in pregnant women with Rh (D) negative, adopting prevent therapeutic measure in time can improve newborn prognosis and according the anti - Rh ( D) level of antibody.%目的 了解Rh (D)阴性孕妇抗-D抗体水平及与婴儿预后的关系.方法 分析2004年1月~2010年12月194例Rh (D)阴性孕妇的妊娠、分娩及其IgG抗-D效价.结果 194例Rh (D)阴性孕妇中有19例产生了抗-D抗体,IgG抗体效价从1∶2-1∶2048不等,其中妊娠≤2胎次9例,抗-D效价从1∶2 - 1∶128,妊娠≥3胎次7例(其中3例孕妇未在本院生产,故未统计在内).抗-D效价从1∶128 - 1∶2048.其中有1例曾输过血的孕妇第1胎产生了抗-D.结论 对Rh(D)阴性孕妇抗-D抗体的检测,根据抗体效价及时采取相应的预防及治疗措施,可明显改善围产儿预后.

  18. 从scFv噬菌体库分离特异性的人源化抗D-dimer抗体%Isolation of specific humanized anti-D-dimer scFv fragments from scFv phage libraries

    Institute of Scientific and Technical Information of China (English)

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv(单链Fv)噬菌体抗体库分离出对D-dimer有特异性的人源化单克隆scFv.方法 对Tomlinson scFv噬菌体文库进行3轮淘洗,富集特异性的抗D-dimer抗体并进行ELISA 验证.通过酶联免疫检测和双脱氧终止法基因测序,获取特异性的人源化单克隆抗体.结果 3轮淘洗选择出38个抗D-dimer噬菌体抗体,酶联免疫和基因测序分析后,20个不同的全长单克隆抗D-dimer scFv噬菌体抗体被筛选出来,3轮选择后阳性克隆获取率为100%;分泌性抗体ELISA结果显示单克隆anti-D-dimer噬菌体顺利表达了抗体蛋白;5个A450值较高的单克隆中,3个显示了对D-dimer的高特异性和亲和力.结论 抗体噬菌体展示技术是分离获取人源化特异性anti-D-dimer抗体的高效快速方法.%Objective To isolate specific humanized anti-D-dimer scFv(single chain Fv) antibody from scFv phage libraries. Methods Isolate anti-D-dimer positive clones from Tomlinson I + J phage libraries by three rounds of panuing, then sequence monoclonal genes by bideoxy-mediated chain termination and express soluble scFv antibody; Pick out anti-D-dimer antibodies with high specificity and affinity by ELISA.Results After three rounds of selection from human scFv phage libraries Tomlinson I and J, 38 monclonal specific anti-D-dimer scFv fragments were selected. By polyclonal and monoclonal phage ELISA and gene sequencing, 20 different full-length monoclonal scFv phages were identified, the result of soluble scFv ELISA showed that 20 full-length monoclonal scFv were expressed smoothly. According to the result of soluble scFv ELISA, in 5 scFv antibodies with high value of A450 selected, 3 scFv antibody fragments showed high specific and affinity. Conclusion Antibody phage display was an effective, rapid method to isolate anti-D-dimer antibodies with high specificity and affinity.

  19. Measurement of D^0-antiD^0 mixing and search for CP violation in D^0 →K^+K^-, π^+*π^- decays with the full Belle data set

    Energy Technology Data Exchange (ETDEWEB)

    Staric, M.; Abdesselam, A.; Adachi, I.; Aihara, H.; Arinstein, K.; Asner, David M.; Aushev, T.; Ayad, R.; Aziz, T.; Babu, V.; Badhrees, I.; Bahinipati, S.; Bakich, A. M.; Bansal, Vikas; Biswal, J.; Bondar, A.; Bonvicini, Giovanni; Bozek, A.; Bracko, Marko; Browder, Thomas E.; Cervenkov, D.; Chekelian, V.; Chen, A.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, K.; Chobanova, V.; Choi, Y.; Cinabro, David A.; Dalseno, J.; Danilov, M.; Dolezal, Z.; Dutta, D.; Eidelman, S.; Epifanov, D.; Farhat, H.; Fast, James E.; Ferber, T.; Fulsom, Bryan G.; Gaur, Vipin; Gabyshev, N.; Ganguly, Sudeshna; Garmash, A.; Gillard, R.; Glattaur, R.; Goh, Y. M.; Goldenzweig, P.; Golob, B.; Grygier, J.; Haba, J.; Hara, Takanori; Hayasaka, K.; Hayashii, H.; He, X. H.; Hou, W. S.; Hsu, C. L.; Iijima, T.; Inami, K.; Inguglia, G.; Ishikawa, A.; Itoh, R.; Jaegle, Igal; Joffe, D.; Julius, T.; Kang, K. H.; Kawasaki, T.; Keck, T.; Kiesling, C.; Kim, D. Y.; Kim, J. B.; Kim, J. H.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kinoshita, Kay; Ko, Byeong Rok; Kodys, P.; Korpar, S.; Krizan, P.; Krokovny, Pavel; Kumita, T.; Kuzmin, A.; Kwon, Y. J.; Lange, J. S.; Lee, I. S.; Lewis, P.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, D.; Lukin, P.; Masuda, M.; Matvienko, D.; Miyabayashi, K.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Moll, A.; Moon, H K.; Mussa, R.; Nakao, M.; Nanut, T.; Natkaniec, Z.; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Pakhlov, P.; Pakhlova, G.; Pal, Bilas K.; Park, C. W.; Park, H.; Pedlar, Todd; Pesantez, L.; Pestotnik, R.; Petric, M.; Piilonen, Leo E.; Ribezl, Eva; Ritter, M.; Rostomyan, A.; Sakai, Y.; Sandilya, Saurabh; Sanuki, T.; Savinov, Vladimir; Schneider, O.; Schnell, G.; Schwanda, C.; Schwartz, A. J.; Senyo, K.; Shebalin, V.; Shen, CP; Shibata, TA; Shiu, Jing-Ge; Shwartz, B.; Simon, F.; Sohn, Y. S.; Sokolov, A.; Solovieva, E.; Stanic, S.; Steder, M.; Sumihama, M.; Tamponi, Umberto; Teramoto, Y.; Trabelsi, K.; Uchida, M.; Uehara, S.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Usov, Y.; Van Hulse, C.; Vanhoefer, P.; Varner, G.; Vinokurova, A.; Vorobyev, V.; Wagner, M. N.; Wang, C. H.; Wang, M. Z.; Wang, P.; Wang, X. L.; Watanabe, M.; Watanabe, Y.; Williams, K. M.; Won, E.; Yashchenko, S.; Yook, Youngmin; Yuan, C. Z.; Zhang, Z. P.; Zhilich, V.; Zhulanov, V.; Ziegler, M.; Zupanc, A.

    2016-02-10

    We report an improved measurement of D^0-antiD^0 mixing and a search for CP violation in D^0 decays to CP-even final states K^+K^- and *π^+π^-*. The mea- surement is based on the final Belle data sample of 976 fb^-1. The results are yCP = (1:11 * +/-0:22 * +/-0:09)% and AΓ = (-0:03 * +/-0:20 * +/-0:07)%, where the first uncertainty is statistical and the second is systematic.

  20. The integration of the "spirituality in medicine" curriculum into the osteopathic communication curriculum at Kansas City University of Medicine and Biosciences.

    Science.gov (United States)

    Talley, Jan A; Magie, Richard

    2014-01-01

    With grant funding from the John Templeton Spirituality and Medicine Curricular Award to the George Washington Institute for Spirituality and Health, faculty at Kansas City University of Medicine and Biosciences (KCUMB) developed the "Spirituality in Medicine" curriculum. In developing the curriculum, faculty took into consideration competencies required by the Association of American Medical Colleges and qualitative results from surveys of medical school applicants and enrolled students. Strategies for curriculum delivery included lectures, panel discussions, role-playing, and training in the use of a spirituality assessment tool. A majority of the 250 students who received the training in 2010-2011 were able to demonstrate the following competencies: (1) being sensitive to patients' spiritual and cultural needs, (2) assessing patients' and their own spiritual needs, (3) appropriately using chaplain services for patient care, and (4) understanding the effects of health disparities and ethical issues on patient care. Challenges to implementation included a reduction in chaplain availability due to the economic downturn, a lack of student exposure to direct patient care during shadowing, too little religious diversity among chaplains, and changes in assignment schedules. New competencies required by the National Board of Osteopathic Medical Examiners overlap with and help ensure sustainability of the Spirituality in Medicine curriculum. KCUMB leaders have incorporated the use of the spirituality assessment tool into other parts of the curriculum and into service experiences, and they have introduced a new elective in palliative care. Synergistic efforts by faculty leaders for this initiative were critical to the implementation of this curriculum. PMID:24280841

  1. Development of a methylation marker set for forensic age estimation using analysis of public methylation data and the Agena Bioscience EpiTYPER system.

    Science.gov (United States)

    Freire-Aradas, A; Phillips, C; Mosquera-Miguel, A; Girón-Santamaría, L; Gómez-Tato, A; Casares de Cal, M; Álvarez-Dios, J; Ansede-Bermejo, J; Torres-Español, M; Schneider, P M; Pośpiech, E; Branicki, W; Carracedo, Á; Lareu, M V

    2016-09-01

    Individual age estimation has the potential to provide key information that could enhance and extend DNA intelligence tools. Following predictive tests for externally visible characteristics developed in recent years, prediction of age could guide police investigations and improve the assessment of age-related phenotype expression patterns such as hair colour changes and early onset of male pattern baldness. DNA methylation at CpG positions has emerged as the most promising DNA tests to ascertain the individual age of the donor of a biological contact trace. Although different methodologies are available to detect DNA methylation, EpiTYPER technology (Agena Bioscience, formerly Sequenom) provides useful characteristics that can be applied as a discovery tool in localized regions of the genome. In our study, a total of twenty-two candidate genomic regions, selected from the assessment of publically available data from the Illumina HumanMethylation 450 BeadChip, had a total of 177 CpG sites with informative methylation patterns that were subsequently investigated in detail. From the methylation analyses made, a novel age prediction model based on a multivariate quantile regression analysis was built using the seven highest age-correlated loci of ELOVL2, ASPA, PDE4C, FHL2, CCDC102B, C1orf132 and chr16:85395429. The detected methylation levels in these loci provide a median absolute age prediction error of ±3.07years and a percentage of prediction error relative to the age of 6.3%. We report the predictive performance of the developed model using cross validation of a carefully age-graded training set of 725 European individuals and a test set of 52 monozygotic twin pairs. The multivariate quantile regression age predictor, using the CpG sites selected in this study, has been placed in the open-access Snipper forensic classification website. PMID:27337627

  2. On limit and limit setting.

    Science.gov (United States)

    Gorney, J E

    1994-01-01

    This article investigates the role of limit and limit setting within the psychoanalytic situation. Limit is understood to be a boundary between self and others, established as an interactional dimension of experience. Disorders of limit are here understood within the context of Winnicott's conception of the "anti-social tendency." Limit setting is proposed as a necessary and authentic response to the patient's acting out via holding and empathic responsiveness, viewed here as a form of boundary delineation. It is proposed that the patient attempts to repair his or her boundary problem through a seeking of secure limits within the analyst. The setting of secure and appropriate limits must arise from a working through of the analyst's own countertransference response to the patient. It is critical that this response be evoked by, and arise from, the immediate therapeutic interaction so that the patient can experience limit setting as simultaneously personal and authentic. PMID:7972580

  3. Education: Bioscience Education through Bioparks.

    Science.gov (United States)

    Robinson, Michael H.

    1988-01-01

    Suggests creating a biological park to stress the interrelationships between plants and animals. States that the techniques of a zoo should be applied to paleontology, anatomy, anthropology. Gives advantages of this creative concept. (RT)

  4. The interfacial bioscience grand challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Pamela; Stevens, Mark Jackson; Jacobsen, Richard B.; Hong, Joohee; Ayson, Marites J.; Crozier, Paul Stewart; Wood, Nichole L.; Schoeniger, Joseph S.; Kruppa, Gary Hermann; Sale, Kenneth L.; Young, Malin M.; Faulon, Jean-Loup Michel; Burns, Alan Richard; Evans, Kervin O.; Novak, Petr

    2004-03-01

    This report is broken down into the following 3 sections: (1) Chemical Cross-linking and Mass Spectrometry Applied to Determination of Protein Structure and Dynamics; (2) Computational Modeling of Membrane Protein Structure and Dynamics; and (3) Studies of Toxin-Membrane Interactions using Single Molecule Biophysical Methods.

  5. Quench limits

    International Nuclear Information System (INIS)

    With thirteen beam induced quenches and numerous Machine Development tests, the current knowledge of LHC magnets quench limits still contains a lot of unknowns. Various approaches to determine the quench limits are reviewed and results of the tests are presented. Attempt to reconstruct a coherent picture emerging from these results is taken. The available methods of computation of the quench levels are presented together with dedicated particle shower simulations which are necessary to understand the tests. The future experiments, needed to reach better understanding of quench limits as well as limits for the machine operation are investigated. The possible strategies to set BLM (Beam Loss Monitor) thresholds are discussed. (author)

  6. Dose limits

    International Nuclear Information System (INIS)

    The dose limit is defined to be the level of harmfulness which must not be exceeded, so that an activity can be exercised in a regular manner without running a risk unacceptable to man and the society. The paper examines the effects of radiation categorised into stochastic and non-stochastic. Dose limits for workers and the public are discussed

  7. Limited Neutrality

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul

    2006-01-01

    Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."......Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."...

  8. Inverse Limits

    CERN Document Server

    Ingram, WT

    2012-01-01

    Inverse limits provide a powerful tool for constructing complicated spaces from simple ones. They also turn the study of a dynamical system consisting of a space and a self-map into a study of a (likely more complicated) space and a self-homeomorphism. In four chapters along with an appendix containing background material the authors develop the theory of inverse limits. The book begins with an introduction through inverse limits on [0,1] before moving to a general treatment of the subject. Special topics in continuum theory complete the book. Although it is not a book on dynamics, the influen

  9. Limiting Skepticism

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella; Symons, John

    2011-01-01

    Skeptics argue that the acquisition of knowledge is impossible given the standing possibility of error. We present the limiting convergence strategy for responding to skepticism and discuss the relationship between conceivable error and an agent’s knowledge in the limit. We argue that the skeptic...... must demonstrate that agents are operating with a bad method or are in an epistemically cursed world. Such demonstration involves a significant step beyond conceivability and commits the skeptic to potentially convergent inquiry...

  10. Rethinking and Reconstruction on Animal Welfare in Experiments of Bioscience%生命科学实验中动物福利问题的反思与重构——基于生态哲学视角

    Institute of Scientific and Technical Information of China (English)

    朱玉芳

    2011-01-01

    针对目前生命科学实验中学生排斥使用实验动物的现象,反思并分析了过度关注动物福利的原因,并在解读生态哲学思想的基础上重构了实验中动物福利问题,旨在为高校的生命科学实验的顺利进行提供启示和借鉴.%At present,according to the phenomenon that students reject experimenting on animal in experiments of bioscience.the article reflects on and analyses the reasons for paying excessive attention to animal welfare,and on the basis of interpreting ecological philosophy,it rebuild the view of animal welfare in experiment,aiming at providing enlightenment and experience for carrying on biological science experiment successfully in college.

  11. Comparison of anti-D immunoglobulin and high-dose intravenous immunoglobulin therapy in childhood acute idiopathic thrombocytopenic purpura:a systematic review and meta-analysis%抗-D免疫球蛋白与大剂量静脉丙种球蛋白治疗儿童急性特发性血小板减少性紫癜的meta分析

    Institute of Scientific and Technical Information of China (English)

    泥永安; 刘壮; 廖必才

    2013-01-01

    Objectives To compare the effectiveness and safety of intravenous anti-D immunoglobulin (IV anti-D) with high-dose intravenous immunoglobulin (IVIG) as initial treatments of acute idiopathic thrombocytopenic purpura (ITP) in children. Methods Randomized controlled trials comparing anti-D with high-dose IVIG in the treatment of childhood acute ITP were systematically reviewed from PubMed, Embase and Cochrane Central Register of Controlled Trials and hand-searched reference lists. The number of patients with a platelet count>20 × 109/L at 72 hours after treatment initia-tion, and the decrease in hemoglobin were the primary outcomes. The meta-analysis was performed by RevMan 5.1. Results A total of 771 relevant articles were retrieved, and ifve studies were included. The RR (anti-D versus high dose IVIG) of achieving a platelet count>20×109/L at 72 hours was 0.90 (95%CI:0.82~0.98). However, subgroup analysis suggested no signiifcant difference between anti-D at a dose of 50μg/kg and high-dose IVIG (RR 0.98, 95% CI: 0.84~1.13), as well as between anti-D at a dose of 75μg/kg and high-dose IVIG (RR 0.88, 95%CI:0.75~1.03). Hemoglobin drop was greater in the anti-D group. No patients, however, required transfusions of erythrocyte suspensions. Conclusions IV anti-D may be as ef-fective as high-dose IVIG in the treatment of childhood acute ITP at 72 hours after therapy. The side effects of anti-D were tolerated and acceptable.%  目的比较静脉注射抗-D免疫球蛋白(anti-D immunoglobulin,anti-D)与大剂量静脉注射免疫球蛋白(IVIG)治疗儿童急性特发性血小板减少性紫癜(ITP)的有效性及安全性。方法计算机检索PubMed、Embase和Cochrane Central Register of Controlled Trials。手工查阅计算机检索到的文献的参考文献目录。选取治疗72 h后血小板计数>20×109/L的百分率和血红蛋白下降值作为主要测量指标。采用RevMan 5.1对纳入文献进行meta分析。

  12. Bioética, violência e desigualdade: as biociências e a constituição do biopoder Bioethics, violence and inequality: the biosciences and the conquest of biopower

    Directory of Open Access Journals (Sweden)

    Hélder Boska de Moraes Sarmento

    2008-12-01

    Full Text Available A sociedade contemporânea está atravessada por contradições e paradoxos, dentre os quais vale destacar a relação entre a alta tecnologia e, a pior situação humana, a miséria. Resultado das escolhas éticas e políticas desta era tecnológica, vive-se em situações de fronteira, nas quais as biociências desempenham papel central, tanto no volume de conhecimentos gerados, como na utilização de seus resultados, que, sem controle social, ampliam desigualdades. O objetivo deste artigo é demonstrar o quanto as biociências articulam-se com o desenvolvimento científico dos países inovadores de tecnologia, criando uma nova relação de poder, violento e desigual para os que apenas a consomem, denominado de biopoder. Daí a necessidade de uma bioética crítica capaz de empreender reflexões sobre os procedimentos técnicos, os fundamentos da atividade científica, sua aplicabilidade e relação com o mercado, oportunizando uma 'ponte' na tomada de decisões para que a própria ciência não se torne um obstáculo à democracia.Contemporary society is rife with contradictions and paradoxes, among which stand out the relationship between high technology and the worst human situation, poverty. The result of ethical and political choices of this technological era, we experience frontier situations, in which the biosciences play a central role, both in the volume of knowledge generated, as well as in the use of their results which, without social control, broaden inequalities. The objective of this article is to demonstrate the degree to which the biosciences are articulated with the scientific development of the countries that innovate technologies, creating a new relationship of power, which is violent and unequal for those who only consume, denominated biopower. This creates a need for a critical bioethics that is capable of reflecting on the technical procedures, the bases of scientific activity and their applicability and relation with

  13. HOME Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — HOME Income Limits are calculated using the same methodology that HUD uses for calculating the income limits for the Section 8 program. These limits are based on...

  14. A search for a neutral D meson - anti-D meson mixing in the semileptonic decay of a neutral D meson decaying to a resonant Kaon in electron volts

    Science.gov (United States)

    McGee, Sean

    2002-04-01

    Using the CLEOII.V dataset, we search for evidence of D 0 - D¯0 mixing through the decay of D0 → K* e n with the K*+/- decaying to K*+/-→K0Sp +/-→p+/-p∓ p+/- . A fit for wrong-sign events, D0→K*+e-n ¯ , gives an upper limit on Rmix=ND0→ D¯0→K*+e -n¯ ND0→K*-e +n at a 95% C.L. of <0.86%.

  15. Limits to adaptation

    Science.gov (United States)

    Dow, Kirstin; Berkhout, Frans; Preston, Benjamin L.; Klein, Richard J. T.; Midgley, Guy; Shaw, M. Rebecca

    2013-04-01

    An actor-centered, risk-based approach to defining limits to social adaptation provides a useful analytic framing for identifying and anticipating these limits and informing debates over society's responses to climate change.

  16. An Adaptive TVD Limiter

    Science.gov (United States)

    Jeng, Yih Nen; Payne, Uon Jan

    1995-05-01

    An adaptive TVD limiter, based on a limiter approximating the upper boundary of the TVD range and that of the third-order upwind TVD scheme, is developed in this work. The limiter switches to the comprressive limiter near a discontinuity, to the third-order TVD scheme's limiter in the smooth region, and to a weighted averaged scheme in the transition region between smooth and high gradient solutions. Numerical experiments show that the proposed scheme works very well for one-dimensional scalar equation problems but becomes less effective in one- and two-dimensional Euler equation problems. Further study is required for the two-dimensional scalar equation problems.

  17. Limit loads in nozzles

    International Nuclear Information System (INIS)

    The static method for the evaluation of the limit loads of a perfectly elasto-plastic structure is presented. Using the static theorem of Limit Analysis and the Finite Element Method, a lower bound for the colapso load can be obtained through a linear programming problem. This formulation if then applied to symmetrically loaded shells of revolution and some numerical results of limit loads in nozzles are also presented. (Author)

  18. Limit analysis via creep

    International Nuclear Information System (INIS)

    In this paper it is presented a variational method for the limit analysis of an ideal plastic solid. This method has been denominated as Modified Secundary Creep and enables to find the collapse loads through a minimization of a functional and a limit process. Given an ideal plastic material it is shown how to determinate the associated secundary creep constitutive equation. Finally, as an application, it is found the limit load in an pressurized von Mises rigid plastic sphere. (Author)

  19. Friction Generated Limit Cycles

    OpenAIRE

    Ohlsson, Henrik; Åström, Karl Johan

    2001-01-01

    This paper treats limit cycles caused by friction. The goal has been to explain phenomena that have been observed experimentally in mechatronic systems. Experiments have shown that oscillations of qualitatively different types can be obtained simply by changing controller specifications. Stiction is important in some cases but not in others. Necessary conditions for limit cycle are given for the case where stiction is important. Conditions for local stability of the limit cycles are also pres...

  20. Limitations to sharing entanglement

    CERN Document Server

    Kim, Jeong San; Sanders, Barry C

    2011-01-01

    We discuss limitations to sharing entanglement known as monogamy of entanglement. Our pedagogical approach commences with simple examples of limited entanglement sharing for pure three-qubit states and progresses to the more general case of mixed-state monogamy relations with multiple qudits.

  1. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  2. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysi...

  3. Universal Limits on Computation

    CERN Document Server

    Krauss, L M

    2004-01-01

    The physical limits to computation have been under active scrutiny over the past decade or two, as theoretical investigations of the possible impact of quantum mechanical processes on computing have begun to make contact with realizable experimental configurations. We demonstrate here that the observed acceleration of the Universe can produce a universal limit on the total amount of information that can be stored and processed in the future, putting an ultimate limit on future technology for any civilization, including a time-limit on Moore's Law. The limits we derive are stringent, and include the possibilities that the computing performed is either distributed or local. A careful consideration of the effect of horizons on information processing is necessary for this analysis, which suggests that the total amount of information that can be processed by any observer is significantly less than the Hawking-Beckenstein entropy associated with the existence of an event horizon in an accelerating universe.

  4. The Hugoniot Elastic Limit Decay Limit

    Science.gov (United States)

    Billingsley, J. P.

    1997-07-01

    The Hugoniot Elastic Limit(HEL) precursor decay in shock loaded solids has been the subject of considerable experimental and theoretical investigation. Comparative evidence is presented to show that the elastic precursor wave particle velocity, UPHEL, for certain materials decays asymptotically with propagation distance to the DeBroglie velocity, V1, level. This is demonstrated for the following materials: iron, aluminum alloy 6061-T6, plexiglas(PMMA), nickel alloy(MAR-M200), and lithium flouride(LiF). The DeBroglie velocity, V1, equals h/2md, where h is Planck's Constant, m is the mass of one atom, and d is the closest distance between atoms. Thus a relationship has been established between a microscopically derived velocity, V1, and a macroscopically observed velocity, UPHEL.

  5. Tokamak pump limiters

    International Nuclear Information System (INIS)

    Recent experiments with a scoop limiter without active internal pumping have been carried out in the PDX tokamak with up to 6MW of auxiliary neutral beam heating. Experiments have also been done with a rotating head pump limiter in the PLT tokamak in conjunction with RF plasma heating. Extensive experiments have been done in the ISX-B tokamak and first experiments have been completed with the ALT-I limiter in TEXTOR. The pump limiter modules in these latter two machines have internal getter pumping. Experiments in ISX-B are with ohmic and auxiliary neutral beam heating. The results in ISX-B and TEXTOR show that active density control and particle removal is achieved with pump limiters. In ISX-B, the boundary layer (or scape-off layer) plasma partially screens the core plasma from gas injection. In both ISX-B and TEXTOR, the pressure internal to the module scales linearly with plasma density but in ISX-B, with neutral beam injection, a nonlinear increase is observed at the highest densities studied. Plasma plugging is the suspected cause. Results from PDX suggest that a region may exist in which core plasma energy confinement improves using a pump limiter during neutral beam injection. Asymmetric radial profiles and an increased edge electron temperature are observed in discharges with improved confinement. The injection of small amounts of neon into ISX-B has more clearly shown an improved electron core energy confinement during neutral beam injection. While carried out with a regular limiter, this Z-mode of operation is ideal for use with pump limiters and should be a way to achieve energy confinement times similar to values for H-mode tokamak plasmas. The implication of all these results for the design of a reactor pump limiter is described

  6. Novel limiter pump topologies

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, J.H.

    1981-01-01

    The use of limiter pumps as the principle plasma exhaust system of a magnetic confinement fusion device promises significant simplification, when compared to previously investigating divertor based systems. Further simplifications, such as the integration of the exhaust system with a radio frequency heating system and with the main reactor shield and structure are investigated below. The integrity of limiters in a reactor environment is threatened by many mechanisms, the most severe of which may be erosion by sputtering. Two novel topolgies are suggested which allow high erosion without limiter failure.

  7. HOME Rent Limits

    Data.gov (United States)

    Department of Housing and Urban Development — In accordance with 24 CFR Part 92.252, HUD provides maximum HOME rent limits. The maximum HOME rents are the lesser of: The fair market rent for existing housing...

  8. SIS - Annual Catch Limit

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Annual Catch Limit (ACL) dataset within the Species Information System (SIS) contains information and data related to management reference points and catch data.

  9. Limited Denial of Participation

    Data.gov (United States)

    Department of Housing and Urban Development — A Limited Denial of Participation (LDP) is an action taken by a HUD Field Office or the Deputy Assistant Secretary for Single Family (DASSF) or Multifamily (DASMF)...

  10. Limited Income and Resources

    Data.gov (United States)

    U.S. Department of Health & Human Services — Information for those with limited income and resources (those who may qualify for or already have the Low Income Subsidy to lower their prescription drug coverage...

  11. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  12. Using information and communication technology (ICT) to the maximum: learning and teaching biology with limited digital technologies

    Science.gov (United States)

    Van Rooy, Wilhelmina S.

    2012-04-01

    Background: The ubiquity, availability and exponential growth of digital information and communication technology (ICT) creates unique opportunities for learning and teaching in the senior secondary school biology curriculum. Digital technologies make it possible for emerging disciplinary knowledge and understanding of biological processes previously too small, large, slow or fast to be taught. Indeed, much of bioscience can now be effectively taught via digital technology, since its representational and symbolic forms are in digital formats. Purpose: This paper is part of a larger Australian study dealing with the technologies and modalities of learning biology in secondary schools. Sample: The classroom practices of three experienced biology teachers, working in a range of NSW secondary schools, are compared and contrasted to illustrate how the challenges of limited technologies are confronted to seamlessly integrate what is available into a number of molecular genetics lessons to enhance student learning. Design and method: The data are qualitative and the analysis is based on video classroom observations and semi-structured teacher interviews. Results: Findings indicate that if professional development opportunities are provided where the pedagogy of learning and teaching of both the relevant biology and its digital representations are available, then teachers see the immediate pedagogic benefit to student learning. In particular, teachers use ICT for challenging genetic concepts despite limited computer hardware and software availability. Conclusion: Experienced teachers incorporate ICT, however limited, in order to improve the quality of student learning.

  13. The quantum geometric limit

    CERN Document Server

    Lloyd, Seth

    2012-01-01

    This letter analyzes the limits that quantum mechanics imposes on the accuracy to which spacetime geometry can be measured. By applying the fundamental physical bounds to measurement accuracy to ensembles of clocks and signals moving in curved spacetime -- e.g., the global positioning system -- I derive a covariant version of the quantum geometric limit: the total number of ticks of clocks and clicks of detectors that can be contained in a four volume of spacetime of radius r and temporal extent t is less than or equal to rt/\\pi x_P t_P, where x_P, t_P are the Planck length and time. The quantum geometric limit bounds the number of events or `ops' that can take place in a four-volume of spacetime: each event is associated with a Planck-scale area. Conversely, I show that if each quantum event is associated with such an area, then Einstein's equations must hold. The quantum geometric limit is consistent with and complementary to the holographic bound which limits the number of bits that can exist within a spat...

  14. Force Limit System

    Science.gov (United States)

    Pawlik, Ralph; Krause, David; Bremenour, Frank

    2011-01-01

    The Force Limit System (FLS) was developed to protect test specimens from inadvertent overload. The load limit value is fully adjustable by the operator and works independently of the test system control as a mechanical (non-electrical) device. When a test specimen is loaded via an electromechanical or hydraulic test system, a chance of an overload condition exists. An overload applied to a specimen could result in irreparable damage to the specimen and/or fixturing. The FLS restricts the maximum load that an actuator can apply to a test specimen. When testing limited-run test articles or using very expensive fixtures, the use of such a device is highly recommended. Test setups typically use electronic peak protection, which can be the source of overload due to malfunctioning components or the inability to react quickly enough to load spikes. The FLS works independently of the electronic overload protection.

  15. Limits on nonlinear electrodynamics

    Science.gov (United States)

    Fouché, M.; Battesti, R.; Rizzo, C.

    2016-05-01

    In this paper we set a framework in which experiments whose goal is to test QED predictions can be used in a more general way to test nonlinear electrodynamics (NLED) which contains low-energy QED as a special case. We review some of these experiments and we establish limits on the different free parameters by generalizing QED predictions in the framework of NLED. We finally discuss the implications of these limits on bound systems and isolated charged particles for which QED has been widely and successfully tested.

  16. The Limits of Laughter.

    Science.gov (United States)

    Mindess, Harvey

    1983-01-01

    Three incidents which elucidate the limits of laughter are described. Most persons enjoy humor as comic relief, but when humor strikes a blow at something they hold dear, they find it very hard to laugh. People are upset by an irreverent attitude toward things they hold in esteem. (RM)

  17. Tightening Home Purchase Limits

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    More Chinese cities will limit home purchase to cool the red-hot real estate market In June 2011,the average house price in 100 Chinese cities was 8,856 yuan ($1,373)per square meter.Of these cities,house prices in 75 of them increased

  18. Occupational dose equivalent limits

    International Nuclear Information System (INIS)

    This paper considers methods of limiting individual radiation risks by recognizing the variation of risk with age at exposure, taking into account both somatic and genetic risks and proposes a simple formula for controlling individual cumulative exposure and hence risk. (Author)

  19. Pushing the Photon Limit

    NARCIS (Netherlands)

    Wientjes, Emilie; Renger, Jan; Cogdell, Richard; Hulst, van Niek F.

    2016-01-01

    Nanoantennas are well-known for their effective role in fluorescence enhancement, both in excitation and emission. Enhancements of 3-4 orders of magnitude have been reported. Yet in practice, the photon emission is limited by saturation due to the time that a molecule spends in singlet and especi

  20. Limits of Lubrication in

    DEFF Research Database (Denmark)

    Olsson, David Dam

    of temperature and contact pressure. The numerical models have been calibrated regarding friction and thermal contact resistance based on experimental results from actual testing conditions. It has been found that predictions of limits of lubrication are possible by numerical means and that the FE...... by strategic surfaces in comparison to normal stainless steel surfaces implying a larger extent of bi-axial stretching. Numerical simulations have been applied in order to evaluate limits of lubrication in the simulative strip reduction based on predictions of critical parameters appearing in terms......-models corresponds well to experimental results in terms of lubricant film breakdown and subsequently pick-up development. Punching and blanking have been investigated regarding tribological conditions in case of using stainless steel workpiece materials. However, this has called for development of a new test method...

  1. Auctions with Limited Commitment

    OpenAIRE

    Qingmin Liu; Konrad Mierendorff; Xianwen Shi

    2013-01-01

    We study auction design in the standard symmetric independent private values environment, where the seller lacks the commitment power to withhold an unsold object off the market. The seller has a single object and can conduct an infinite sequence of standard auctions with reserve prices to maximize her expected profit. In each period, the seller can commit to a reserve price for the current period but cannot commit to future reserve prices. We analyze the problem with limited commitment throu...

  2. Limits of proton conductivity.

    Science.gov (United States)

    Kreuer, Klaus-Dieter; Wohlfarth, Andreas

    2012-10-15

    Parasitic current seems to be the cause for the "highest proton conductivity" of a material reported to date. Kreuer and Wohlfarth verify this hypothesis by measuring the conductivity of the same materials after preparing them in a different way. They further explain the limits of proton conductivity and comment on the problems of determining the conductivity of small objects (e.g., whiskers, see picture).

  3. Limiting Similarity Revisited

    OpenAIRE

    Szabo, P; Meszena, G.

    2005-01-01

    We reinvestigate the validity of the limiting similarity principle via numerical simulations of the Lotka-Volterra model. A Gaussian competition kernel is employed to describe decreasing competition with increasing difference in a one-dimensional phenotype variable. The simulations are initiated by a large number of species, evenly distributed along the phenotype axis. Exceptionally, the Gaussian carrying capacity supports coexistence of all species, initially present. In case of any other, d...

  4. Limitations in forensic odontology

    Directory of Open Access Journals (Sweden)

    B Kavitha

    2009-01-01

    Full Text Available The concept of using dental evidence in forensic investigation has kindled so much interest in the recent past that forensic odontology is even suggested as the single positive identification method to solve certain forensic cases. In this process, the shortcomings in forensic odontology though few are overlooked. These discrepancies associated with various methods are to be weighed cautiously to make forensic odontology a more accurate, reliable, and reproducible investigatory science. In this paper, we present our understanding of the limitations in various methods employed in forensic odontology.

  5. Limitation of Auditors' Liability

    DEFF Research Database (Denmark)

    Werlauff, Erik; Foged-Ladefoged, Lise Kolding

    2014-01-01

    The article examines the question of whether rules on the limitation of auditors’ liability within the perspective of EU law are needed, and if so, which rules can provide an appropriate balance between the potential injured party’s interests and those of the auditing sector, including with respect...... to the fact that the insurance premiums associated with an unlimited liability must of course make the auditor’s tasks more expensive. Relevant EU recommendations and a comparative glance at other EU countries’ proposed solutions to the problem are included....

  6. Orind Refractories Limited

    Institute of Scientific and Technical Information of China (English)

    Mr R. Mishra; Group Manging Director

    2005-01-01

    @@ "Sight can be acquired, Vision cannot". Orind Refractories Limited (ORIND), China was formed with this rare vision. At a time when the world was testing the tepid waters of China; Mr. Ravin Jhunjhunwala, Chairman of ORIND and the management of ORIND India had looked over the Great Wall to begin a journey of success. Incorported on 18th August 1994 with an initial investment of USD 5 million, ORL caters to the ever-demanding needs of the steel industry and beyond. Incidentally ORIND was the first wholly owned India company to set up base in China. Pesently, ORIND China has a 616 strong work force including 23 expatriates.

  7. Limitations of inclusive fitness.

    Science.gov (United States)

    Allen, Benjamin; Nowak, Martin A; Wilson, Edward O

    2013-12-10

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed.

  8. (Limiting the greenhouse effect)

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.

    1991-01-07

    Traveler attended the Dahlem Research Conference organized by the Freien Universitat, Berlin. The subject of the conference was Limiting the Greenhouse Effect: Options for Controlling Atmospheric CO{sub 2} Accumulation. Like all Dahlem workshops, this was a meeting of scientific experts, although the disciplines represented were broader than usual, ranging across anthropology, economics, international relations, forestry, engineering, and atmospheric chemistry. Participation by scientists from developing countries was limited. The conference was divided into four multidisciplinary working groups. Traveler acted as moderator for Group 3 which examined the question What knowledge is required to tackle the principal social and institutional barriers to reducing CO{sub 2} emissions'' The working rapporteur was Jesse Ausubel of Rockefeller University. Other working groups examined the economic costs, benefits, and technical feasibility of options to reduce emissions per unit of energy service; the options for reducing energy use per unit of GNP; and the significant of linkage between strategies to reduce CO{sub 2} emissions and other goals. Draft reports of the working groups are appended. Overall, the conference identified a number of important research needs in all four areas. It may prove particularly important in bringing the social and institutional research needs relevant to climate change closer to the forefront of the scientific and policy communities than hitherto.

  9. Smoothness of limit functors

    Indian Academy of Sciences (India)

    Benedictus Margaux

    2015-05-01

    Let be a scheme. Assume that we are given an action of the one dimensional split torus $\\mathbb{G}_{m,S}$ on a smooth affine -scheme $\\mathfrak{X}$. We consider the limit (also called attractor) subfunctor $\\mathfrak{X}_{}$ consisting of points whose orbit under the given action `admits a limit at 0’. We show that $\\mathfrak{X}_{}$ is representable by a smooth closed subscheme of $\\mathfrak{X}$. This result generalizes a theorem of Conrad et al. (Pseudo-reductive groups (2010) Cambridge Univ. Press) where the case when $\\mathfrak{X}$ is an affine smooth group and $\\mathbb{G}_{m,S}$ acts as a group automorphisms of $\\mathfrak{X}$ is considered. It also occurs as a special case of a recent result by Drinfeld on the action of $\\mathbb{G}_{m,S}$ on algebraic spaces (Proposition 1.4.20 of Drinfeld V, On algebraic spaces with an action of $\\mathfrak{G}_{m}$, preprint 2013) in case is of finite type over a field.

  10. Limits to biofuels

    Directory of Open Access Journals (Sweden)

    Johansson S.

    2013-06-01

    Full Text Available Biofuel production is dependent upon agriculture and forestry systems, and the expectations of future biofuel potential are high. A study of the global food production and biofuel production from edible crops implies that biofuel produced from edible parts of crops lead to a global deficit of food. This is rather well known, which is why there is a strong urge to develop biofuel systems that make use of residues or products from forest to eliminate competition with food production. However, biofuel from agro-residues still depend upon the crop production system, and there are many parameters to deal with in order to investigate the sustainability of biofuel production. There is a theoretical limit to how much biofuel can be achieved globally from agro-residues and this amounts to approximately one third of todays’ use of fossil fuels in the transport sector. In reality this theoretical potential may be eliminated by the energy use in the biomass-conversion technologies and production systems, depending on what type of assessment method is used. By surveying existing studies on biofuel conversion the theoretical limit of biofuels from 2010 years’ agricultural production was found to be either non-existent due to energy consumption in the conversion process, or up to 2–6000TWh (biogas from residues and waste and ethanol from woody biomass in the more optimistic cases.

  11. Speed Limits for Entanglement

    CERN Document Server

    Hartman, Thomas

    2015-01-01

    We show that in any relativistic system, entanglement entropy obeys a speed limit set by the entanglement in thermal equilibrium. The bound is derived from inequalities on relative entropy with respect to a thermal reference state. Thus the thermal state constrains far-from-equilibrium entanglement dynamics whether or not the system actually equilibrates, in a manner reminiscent of fluctuation theorems in classical statistical mechanics. A similar shape-dependent bound constrains the full nonlinear time evolution, supporting a simple physical picture for entanglement propagation that has previously been motivated by holographic calculations in conformal field theory. We discuss general quantum field theories in any spacetime dimension, but also derive some results of independent interest for thermal relative entropy in 1+1d CFT.

  12. Physical limits to magnetogenetics.

    Science.gov (United States)

    Meister, Markus

    2016-01-01

    This is an analysis of how magnetic fields affect biological molecules and cells. It was prompted by a series of prominent reports regarding magnetism in biological systems. The first claims to have identified a protein complex that acts like a compass needle to guide magnetic orientation in animals (Qin et al., 2016). Two other articles report magnetic control of membrane conductance by attaching ferritin to an ion channel protein and then tugging the ferritin or heating it with a magnetic field (Stanley et al., 2015; Wheeler et al., 2016). Here I argue that these claims conflict with basic laws of physics. The discrepancies are large: from 5 to 10 log units. If the reported phenomena do in fact occur, they must have causes entirely different from the ones proposed by the authors. The paramagnetic nature of protein complexes is found to seriously limit their utility for engineering magnetically sensitive cells. PMID:27529126

  13. 极限%Limit

    Institute of Scientific and Technical Information of China (English)

    薛振邦

    2012-01-01

    Limit is the theoretical basis of higher mathematics. It defines the basic concept of differential and integral calculus. Therefore,it is the indispensible step to learn higher mathematics.%极限是高等数学的理论基础,用它定义了微积分的基本概念,因此说极限是步入高等数学殿堂的门槛.从中学到大学,很多学生都感到学习高等数学的不适应性.欲尽快适应,需认识数学的特点和极限的本质,同时要解决两个问题:一是学习方法的转变,二是思维方式的转变.

  14. Clinical limitations of Invisalign.

    Science.gov (United States)

    Phan, Xiem; Ling, Paul H

    2007-04-01

    Adult patients seeking orthodontic treatment are increasingly motivated by esthetic considerations. The majority of these patients reject wearing labial fixed appliances and are looking instead to more esthetic treatment options, including lingual orthodontics and Invisalign appliances. Since Align Technology introduced the Invisalign appliance in 1999 in an extensive public campaign, the appliance has gained tremendous attention from adult patients and dental professionals. The transparency of the Invisalign appliance enhances its esthetic appeal for those adult patients who are averse to wearing conventional labial fixed orthodontic appliances. Although guidelines about the types of malocclusions that this technique can treat exist, few clinical studies have assessed the effectiveness of the appliance. A few recent studies have outlined some of the limitations associated with this technique that clinicians should recognize early before choosing treatment options.

  15. The Limits to Relevance

    Science.gov (United States)

    Averill, M.; Briggle, A.

    2006-12-01

    Science policy and knowledge production lately have taken a pragmatic turn. Funding agencies increasingly are requiring scientists to explain the relevance of their work to society. This stems in part from mounting critiques of the "linear model" of knowledge production in which scientists operating according to their own interests or disciplinary standards are presumed to automatically produce knowledge that is of relevance outside of their narrow communities. Many contend that funded scientific research should be linked more directly to societal goals, which implies a shift in the kind of research that will be funded. While both authors support the concept of useful science, we question the exact meaning of "relevance" and the wisdom of allowing it to control research agendas. We hope to contribute to the conversation by thinking more critically about the meaning and limits of the term "relevance" and the trade-offs implicit in a narrow utilitarian approach. The paper will consider which interests tend to be privileged by an emphasis on relevance and address issues such as whose goals ought to be pursued and why, and who gets to decide. We will consider how relevance, narrowly construed, may actually limit the ultimate utility of scientific research. The paper also will reflect on the worthiness of research goals themselves and their relationship to a broader view of what it means to be human and to live in society. Just as there is more to being human than the pragmatic demands of daily life, there is more at issue with knowledge production than finding the most efficient ways to satisfy consumer preferences or fix near-term policy problems. We will conclude by calling for a balanced approach to funding research that addresses society's most pressing needs but also supports innovative research with less immediately apparent application.

  16. LIMITED LIABILITY DALAM LIMITED LIABILITY PADA KONSTRUKSI PERUSAHAAN KELOMPOK PIRAMIDA

    Directory of Open Access Journals (Sweden)

    Ms. Sulistiowati

    2011-06-01

    Full Text Available Applicability of limited liability in corporate groups with pyramid construction creates a legal loophole in the form of a limited liability within a limited liability. To prevent moral hazard, it is necessary to stipulate new law that limits the number of levels in a corporate group. Berlakunya limited liability pada perusahaan kelompok dengan konstruksi piramida menciptakan celah hukum berupa limited liability dalam limited liability. Untuk mencegah munculnya moral hazard dari pemegang akhir atau induk perbuatan, perlu dilakukan terobosan hukum pembatasan jumlah lapisan anak perusahaan dalam konstruksi perusahaan kelompok.

  17. The limits of deterrence

    International Nuclear Information System (INIS)

    The objective of this contribution is to propose a better insight of the validity of the theory of deterrence, and of related doctrines in more complex and more various situations than in the past: emergence of powers like China and India, of new nuclear States like North Korea and Pakistan, of countries planning to acquire nuclear weapons like Iran, and possibility of a new wave of nuclear proliferation in Middle-East and north-eastern Asia. It also aims at providing arguments in the debates on the struggle against nuclear proliferation and on the future of deterrence. The author first presents and comments the principles of deterrence, and illustrates them by more or less recent historical situations (Iran during the war with Iraq, USA after Pearl Harbour, Arab-Israeli wars, Iraq, and so on). He notably outlines that the notion of deterrence is present in Islamic culture, and that Iran has well integrated it in its defence strategy. Examples of statements and behaviours of other Arab leaders are discussed. The author also briefly indicates how the deterrence strategy is present in the official doctrines of Russia, India, Pakistan, and North Korea. In a second part, based on various examples, the author analyses the practical limitations of deterrence by distinguishing the psychological dimension (bounded rationality, political leaders suffering from various psychological problems, importance of the ideological and spiritual dimension, values prevailing on interests, the case of Iran), and the strategic dimension (good understanding of the enemy, sensitivity of the threat of massive damages, existence of a single decision centre and of an efficient communication). The author finally proposes seven recommendations for better deterrence efficiency

  18. Limits to Tidal Power

    Science.gov (United States)

    Garrett, C.

    2008-12-01

    Ocean tides have been proposed as a source of renewable energy, though the maximum available power may be shown to be only a fraction of the present dissipation rate of 3.5 TW, which is small compared with global insolation (nearly 105 TW), wind dissipation (103 TW), and even human power usage of 15 TW. Nonetheless, tidal power could be a useful contributor in some locations. Traditional use of tidal power, involving the trapping of water behind a barrage at high tide, can produce an average power proportional to the area of the headpond and the square of the tidal range; the power density is approximately 6 W per square meter for a tidal range of 10 m. Capital costs and fears of environmental damage have put barrage schemes in disfavor, with interest turning to the exploitation of strong tidal currents, using turbines in a manner similar to wind turbines. There is a limit to the available power, however, as adding turbines reduces the flow, ultimately reducing the power. For sinusoidal forcing of flow in a channel connecting two large open basins, the maximum available power may be shown to be given approximately by 0.2ρ g a Q_max, where ρ is the water density, g gravity, a the amplitude of the tidal sea level difference along the channel, and Q_max is the maximum volume flux in the natural state. The same formula applies if the channel is the entrance to a semi-enclosed basin, with a now the amplitude of the external tide. A flow reduction of approximately 40% is typically associated with the maximum power extraction. The power would be reduced if only smaller environmental changes are acceptable, and reduced further by drag on supporting structures, dissipation in turbine wakes, and internal inefficiencies. It can be suggested that the best use of strong, cold, tidal currents is to provide cooling water for nuclear reactors.

  19. Charter Halibut Limited Access Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This limited access system limits the number of charter vessels that may participate in the guided sport fishery for halibut in area 2C and 3A. NMFS issues a...

  20. Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Star Lake Bioscience Co.

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2014-06-01

    Full Text Available The product L-Threonine is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli. L-Threonine is an essential amino acid for all animal species. It is commonly considered the second and third limiting amino acid in cereal-based diets for pigs and poultry, respectively. It is widely used in the feed industry to optimise dietary protein. The amino acid L-threonine itself is considered safe for the target animals, the consumer and the environment. However, the possible presence of the production strain and its recombinant DNA, including antibiotic resistance genes used in the genetic modification process, in the final product cannot be excluded. Consequently, the FEEDAP Panel cannot conclude on the safety of L-threonine produced by fermentation with such E. coli strain for the target animals, consumers and the environment. Regardless of the assessment of the genetic modification, the FEEDAP Panel has concerns regarding the safety of amino acids, including L-threonine, for target species when administered via water for drinking. From the results provided, it is concluded that there is no concern for users in respect of respiratory toxicity, or skin or eye irritancy. In the absence of any data on sensitisation, it is concluded that the product may have the potential to be a dermal sensitiser. The concerns regarding the safety of the genetic modification may also have implications for the safety of the user. The product L-threonine is an efficacious source of supplemented amino acid which helps to maintain or restore the adequate balance of dietary amino acids for all non-ruminant species. Supplemental L-threonine is degraded by ruminal microorganisms if not given in a protected form.

  1. A ciência como cultura do mundo contemporâneo: a utopia dos saberes das (biociências e a construção midiática do imaginário social Science as culture in the modern world: the utopia of knowledge in (biosciences and the media construction of social imaginary

    Directory of Open Access Journals (Sweden)

    Madel Luz

    2013-04-01

    Full Text Available O artigo trata essencialmente do papel das biociências, visto como uma cultura específica, no imaginário social contemporâneo, no que concerne à vida, à saúde e ao viver humano em todas as suas fases. Os meios de comunicação, sobretudo através da imprensa de divulgação de massa - sendo privilegiada no artigo a imprensa escrita - difundem para o conjunto da sociedade modos de pensar e agir derivadas das atividades científicas, em andamento ou finalizadas, na área das biociências, que compõem um campo disciplinar especializado de amplo espectro. Destacamos no texto a autoridade não apenas intelectual como moral do discurso normativo oriundo dessas atividades, face a outros discursos presentes na cultura, sejam eles tradicionais - de origem nativa ou externa, como as orientais - sejam eles paralelos atuais, como os das chamadas medicinas ou saberes terapêuticos alternativos derivados dos movimentos de contracultura que remontam aos anos setentas. Nossa hipótese é que esta influência normativa atinge áreas do viver e setores cada vez mais amplos das populações, sendo possível afirmar que as ciências sociais, sobretudo a sociologia, não vêm atribuindo à questão da vida e da saúde humanas a mesma importância que atribui a outros aspectos da vida social, e que é urgente pensar a cultura da vida e do viver veiculada pelas biociências.This article deals with the growing influence of the so called biosciences, a large scope of disciplines concerning life, mainly human life, its origin, "normal" characteristics and evolution processes, from birth to death, in present culture. We are particularly interested in the effects of the discoveries and controversies of the diffusion of results of the research process in social imaginary. Through the mass media divulgation -specially press, mainly the magazines having as its objective the scientific research diffusion, an ensemble of rules about the way of conducting "normal" live

  2. On the validity of the basis set superposition error and complete basis set limit extrapolations for the binding energy of the formic acid dimer

    Energy Technology Data Exchange (ETDEWEB)

    Miliordos, Evangelos; Xantheas, Sotiris S.

    2015-03-07

    We report the variation of the binding energy of the formic acid dimer at the CCSD(T)/ Complete Basis Set limit and examine the validity of the BSSE-correction, previously challenged by Kalescky, Kraka and Cremer [J. Chem. Phys. 140 (2014) 084315]. Our best estimate of D0=14.3±0.1 kcal/mol is in excellent agreement with the experimental value of 14.22±0.12 kcal/mol. The BSSE correction is indeed valid for this system since it exhibits the expected behavior of decreasing with increasing basis set size and its inclusion produces the same limit (within 0.1 kcal/mol) as the one obtained from extrapolation of the uncorrected binding energy. This work was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences. Pacific Northwest National Laboratory (PNNL) is a multiprogram national laboratory operated for DOE by Battelle. A portion of this research was performed using the Molecular Science Computing Facility (MSCF) in EMSL, a national scientific user facility sponsored by the Department of Energy’s Office of Biological and Environmental Research and located at PNNL.

  3. Material Limitations on the Detection Limit in Refractometry

    Directory of Open Access Journals (Sweden)

    Niels Asger Mortensen

    2009-10-01

    Full Text Available We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly.

  4. Material Limitations on the Detection Limit in Refractometry

    CERN Document Server

    Skafte-Pedersen, Peder; Xiao, Sanshui; Mortensen, Niels Asger; 10.3390/s91108382

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min{Dn} > eta with n+i*eta being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because silicon absorbs strongly.

  5. Material Limitations on the Detection Limit in Refractometry

    OpenAIRE

    Niels Asger Mortensen; Sanshui Xiao; Peder Skafte-Pedersen; Pedro S. Nunes

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a...

  6. Material limitations on the detection limit in refractometry

    DEFF Research Database (Denmark)

    Skafte-Pedersen, Peder; Nunes, Pedro; Xiao, Sanshui;

    2009-01-01

    and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm) of silicon...

  7. Welfare Dynamics Under Time Limits

    OpenAIRE

    Jeff Grogger; Charles Michalopoulos

    1999-01-01

    Among the most important changes brought about by the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) is the imposition of time limits. In this paper, we analyze a simple model in which a potential welfare recipient chooses how to allocate her time-limited endowment of benefits so as to maximize her expected lifetime utility. Not surprisingly, the model reveals that time limits provide an incentive for the consumer to conserve, or bank, her benefits. More inte...

  8. Limit cycles in quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Niemann, Patrick

    2015-04-27

    In this thesis we investigate Limit Cycles in Quantum Systems. Limit cycles are a renormalization group (RG) topology. When degrees of freedom are integrated out, the coupling constants flow periodically in a closed curve. The presence of limit cycles is restricted by the necessary condition of discrete scale invariance. A signature of discrete scale invariance and limit cycles is log-periodic behavior. The first part of this thesis is concerned with the study of limit cycles with the similarity renormalization group (SRG). Limit cycles are mainly investigated within conventional renormalization group frameworks, where degrees of freedom, which are larger than a given cutoff, are integrated out. In contrast, in the SRG potentials are unitarily transformed and thereby obtain a band-diagonal structure. The width of the band structure can be regarded as an effective cutoff. We investigate the appearance of limit cycles in the SRG evolution. Our aim is to extract signatures as well as the scaling factor of the limit cycle. We consider the 1/R{sup 2}-potential in a two-body system and a three-body system with large scattering lengths. Both systems display a limit cycle. Besides the frequently used kinetic energy generator we apply the exponential and the inverse generator. In the second part of this thesis, Limit Cycles at Finite Density, we examine the pole structure of the scattering amplitude for distinguishable fermions at zero temperature in the medium. Unequal masses and a filled Fermi sphere for each fermion species are considered. We focus on negative scattering lengths and the unitary limit. The properties of the three-body spectrum in the medium and implications for the phase structure of ultracold Fermi gases are discussed.

  9. Solubility limits on radionuclide dissolution

    Energy Technology Data Exchange (ETDEWEB)

    Kerrisk, J.F.

    1984-12-31

    This paper examines the effects of solubility in limiting dissolution rates of a number of important radionuclides from spent fuel and high-level waste. Two simple dissolution models were used for calculations that would be characteristics of a Yucca Mountain repository. A saturation-limited dissolution model, in which the water flowing through the repository is assumed to be saturated with each waste element, is very conservative in that it overestimates dissolution rates. A diffusion-limited dissolution model, in which element-dissolution rates are limited by diffusion of waste elements into water flowing past the waste, is more realistic, but it is subject to some uncertainty at this time. Dissolution rates of some elements (Pu, Am, Sn, Th, Zr, Sm) are always limited by solubility. Dissolution rates of other elements (Cs, Tc, Np, Sr, C, I) are never solubility limited; their release would be limited by dissolution of the bulk waste form. Still other elements (U, Cm, Ni, Ra) show solubility-limited dissolution under some conditions. 9 references, 3 tables.

  10. Delving into Limits of Sequences

    Science.gov (United States)

    Cory, Beth; Smith, Ken W.

    2011-01-01

    Limits are foundational to the central concepts of calculus. However, the authors' experiences with students and educational research abound with examples of students' misconceptions about limits and infinity. The authors wanted calculus students to understand, appreciate, and enjoy their first introduction to advanced mathematical thought. Thus,…

  11. Time Limits and Welfare Use

    Science.gov (United States)

    Grogger, Jeffrey

    2004-01-01

    Time limits represent a substantial departure from previous welfare policy. Theory suggests that their effects should vary according to the age of the youngest child of the family. I test this prediction using data from the Current Population Survey and find that time limits indeed have larger effects on families with younger children. I further…

  12. Tokamak plasma interaction with limiters

    International Nuclear Information System (INIS)

    The importance of plasma purity is first discussed in terms of the general requirements of controlled thermonuclear fusion. The tokamak approach to fusion and its inherent problem of plasma contamination are introduced. A main source of impurities is due to the bombardment of the limiter by energetic particles and thus the three main aspects of the plasma-limiter interaction are reviewed, boundary plasma conditions, fuelling/recycling and impurity production. The experiments, carried out on the DITE tokamak at Culham Laboratory, UK, investigated these three topics and the results are compared with predicted behaviour; new physical phenomena are presented in all three areas. Simple one-dimensional fluid equations are found to adequately describe the SOL plasma, except in regard to the pre-sheath electric field and ambipolarity; that is, the electric field adjacent to the limiter surface appears to be weak and the associated plasma flow can be non-ambipolar. Recycling of fuel particles from the limiter is observed to be near unity at all times. The break-up behaviour of recycled and gas puffed D2 molecules is dependent on the electron temperature, as expected. Impurity production at the limiter is chemical erosion of graphite being negligible. Deposition of limiter and wall-produced impurities is found on the limiter. The spatial distributions of impurities released from the limiter are observed and are in good agreement with a sputtered atom transport code. Finally, preliminary experiments on the transport of impurity ions along field lines away from the limiter have been performed and compared with simple analytic theory. The results suggest that the pre-sheath electric field in the SOL is much weaker than the simple fluid model would predict

  13. The bioscience revolution & the biological weapons threat: levers & interventions

    Directory of Open Access Journals (Sweden)

    Martin Greg

    2009-02-01

    Full Text Available Abstract In December 2008, the US Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, released a report, World At Risk. The Report points to the fact that, not only is the use of a weapon of mass destruction in a terrorist attack before the end of 2013, more likely than not, but also to the fact that terrorists are more likely to be able to obtain and use biological weapons than nuclear. This paper examines the recommendations of the report in the context of the historic and geopolitical changes, in particular globalization. The authors highlight the "dual-use" dilemma, as described in the report, as the paradoxical use of technology developed for the benefit of mankind being used for sinister purposes. The mitigation of such a threat lies in broad stakeholder involvement and cooperation, including non-state actors, governments and the bio-tech industry itself. The importance of vigilance measures within the life science community is emphasized and, the authors propose, could include a web-based didactic course in bioterrorism and weapons of mass destruction identification. The site could outline safety protocols, have detailed disaster management tutorials, and could be specifically tailored for different subsets of industry and health professionals. The paper concludes with an endorsement of a multi-pronged approach including strong international guidelines and intelligence cooperation and preparatory measures such as the wide-spread use of detection systems as well as diagnostic decision support systems for bioterrorism detection at the local level.

  14. Cloning: Past, Present, and the Exciting Future. Breakthroughs in Bioscience.

    Science.gov (United States)

    Di Berardino, Marie A.

    This document explores the history of cloning by focusing on Dolly the Sheep, one of the first large animal clonings. The disadvantages and advantages of transgenic clones are discussed as well as the future implications of cloning from the perspective of human health. (Contains 10 resources.) (YDS)

  15. The Utility of Writing Assignments in Undergraduate Bioscience

    Science.gov (United States)

    Libarkin, Julie; Ording, Gabriel

    2012-01-01

    We tested the hypothesis that engagement in a few, brief writing assignments in a nonmajors science course can improve student ability to convey critical thought about science. A sample of three papers written by students (n = 30) was coded for presence and accuracy of elements related to scientific writing. Scores for different aspects of…

  16. Perfinity Biosciences - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Determining the relationship between the function of an isolated protein and the function of that protein in a complex cellular environment is a significant analytical endeavor. Due to the time and cost associated with developing an enzyme linked immunoassay (ELISA), mass spectrometric approaches are playing an increasingly large role in protein analyses.

  17. Fundamental Limits of Ultrathin Metasurfaces

    CERN Document Server

    Arbabi, Amir

    2014-01-01

    We present universal theoretical limits on the operation and performance of non-magnetic passive ultrathin metasurfaces. In particular, we prove that their local transmission, reflection, and polarization conversion coefficients are confined to limited regions of the complex plane. As a result, full control over the phase of the light transmitted through such metasurfaces cannot be achieved if the polarization of the light is not to be affected at the same time. We also establish fundamental limits on the maximum polarization conversion efficiency of these metasurfaces, and show that they cannot achieve more than 25% polarization conversion efficiency in transmission.

  18. Physical limits to biochemical signaling

    CERN Document Server

    Bialek, W

    2003-01-01

    Many crucial biological processes operate with surprisingly small numbers of molecules, and there is renewed interest in analyzing the impact of noise associated with these small numbers. Twenty--five years ago, Berg and Purcell showed that bacterial chemotaxis, where a single celled organism must respond to small changes in concentration of chemicals outside the cell, is limited directly by molecule counting noise, and that aspects of the bacteria's behavioral and computational strategies must be chosen to minimize the effects of this noise. Here we revisit and generalize their arguments to estimate the physical limits to signaling processes within the cell, and argue that recent experiments are consistent with performance approaching these limits.

  19. A cidade: limite do mundo

    OpenAIRE

    Borges Abel, António

    2010-01-01

    A cidade é hoje, por força do desenvolvimento das NTIC, uma cidade alargada ou, se se preferir, uma “aldeia global”. Porém, se sob o ponto de vista da comunicação, os limites da cidade se confundem com os limites do mundo, sob o ponto de vista da cidade física, geográfica, o “capitalismo cognitivo” força cada vez mais aquela a não conhecer limites, a transformar a hibridez num novo conceito e numa nova realidade espacial, pulverizando a anterior realidade: a cidade como contraponto do camp...

  20. Limit laws for Zipf's law

    International Nuclear Information System (INIS)

    In this communication we establish stochastic limit laws leading from Zipf's law to Pareto's and Heaps' laws. We consider finite ensembles governed by Zipf's law and study their asymptotic statistics as the ensemble size tends to infinity. A Lorenz-curve analysis establishes three types of limit laws for the ensembles' statistical structure: 'communist', 'monarchic', and Paretian. Further considering a dynamic setting in which the ensembles grow stochastically in time, a functional central limit theorem analysis establishes a Gaussian approximation for the ensembles' stochastic growth. The Gaussian approximation provides a generalized and corrected formulation of Heaps' law. (fast track communication)

  1. The plastic limit of clays

    OpenAIRE

    Haigh, Stuart K.; Vardanega, Paul J.; Bolton, Malcolm D.

    2013-01-01

    The plastic limit of soils was first described by Atterberg in 1911. The thread-rolling test was standardised at the US Public Roads Bureau in the 1920s and 1930s, and has subsequently become one of the standard tests of soil mechanics. This paper reviews the original definitions of plastic limit as proposed by Atterberg, and proposes that the brittle failure observed in the plastic limit test is caused by either air entry or cavitation in the clay. Critical state soil mechanics is used to sh...

  2. The Limits to Giving Back

    Directory of Open Access Journals (Sweden)

    Jade S. Sasser

    2014-07-01

    Full Text Available In this thematic section, authors consider the limitations on giving back that they faced in field research, or saw others face. For some authors, their attempts at giving back were severely limited by the scope of their projects, or their understandings of local cultures or histories. For others, very specific circumstances and historical interventions of foreigners in certain places can limit how and to what extent a researcher is able to have a reciprocal relationship with the participating community. Some authors, by virtue of their lesser positions of power relative to those that they were studying, simply decided not to give back to those communities. In each article it becomes apparent that how and in what ways people give back is unique (and limited both to their personal values and the contexts in which they do research.

  3. Multifamily Tax Subsidy Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Multifamily Tax Subsidy Projects (MTSP) Income Limits were developed to meet the requirements established by the Housing and Economic Recovery Act of 2008 (Public...

  4. Brassicas limited in weed control

    OpenAIRE

    Kristiansen, Mr P

    2006-01-01

    This article discusses the limitations of using brassica cover crops for weed control. A brief overview of the role of cover crops is provided, followed by a short review of research looking at brassica cover crops.

  5. Limit cycles of effective theories

    OpenAIRE

    Glazek, Stanislaw D.

    2006-01-01

    A simple example is used to show that renormalization group limit cycles of effective quantum theories can be studied in a new way. The method is based on the similarity renormalization group procedure for Hamiltonians. The example contains a logarithmic ultraviolet divergence that is generated by both real and imaginary parts of the Hamiltonian matrix elements. Discussion of the example includes a connection between asymptotic freedom with one scale of bound states and the limit cycle with a...

  6. Penrose Limits and Spacetime Singularities

    OpenAIRE

    Blau, Matthias; Borunda, Monica; O'Loughlin, Martin; Papadopoulos, George

    2003-01-01

    We give a covariant characterisation of the Penrose plane wave limit: the plane wave profile matrix $A(u)$ is the restriction of the null geodesic deviation matrix (curvature tensor) of the original spacetime metric to the null geodesic, evaluated in a comoving frame. We also consider the Penrose limits of spacetime singularities and show that for a large class of black hole, cosmological and null singularities (of Szekeres-Iyer ``power-law type''), including those of the FRW and Schwarzschil...

  7. Time Limits and Welfare Use

    OpenAIRE

    Jeff Grogger

    2000-01-01

    Time limits are a central component of recent welfare reforms and represent a substantial departure from previous policy. However, several recent studies suggest that they have had no effect on welfare use. In this paper I attempt to reconcile those findings with results from Grogger and Michalopoulos, who find time limits to have substantial effects that vary by the age of the youngest child in the family. Using data from the Current Population Survey, I obtain results similar to those of pr...

  8. Time Limits : Effects on Recall

    OpenAIRE

    Hirano, Kinue

    2000-01-01

    This study investigates the effects of differing time limits and the level of language proficiency on the written recalls of 66 Japanese EFL undergraduates. Results showed that different time limits affected total recall, but not main ideas recalled. Regardless of proficiency level, the 20-minute group (Group 2) recalled a greater number of idea units than the 8-minute group (Group 1). However, no significant difference was found between Groups 1 and 2 regarding the recall of main ideas, alth...

  9. Statistical limitations on molecular evolution.

    Science.gov (United States)

    Perlovsky, Leonid I

    2002-06-01

    Complexity of functions evolving in an evolution process are expected to be limited by the time length of an evolution process among other factors. This paper outlines a general method of deriving function-complexity limitations based on mathematical statistics and independent from details of a biological or genetic mechanism of the evolution of the function. Limitations on the emergence of life are derived, these limitations indicate a possibility of a very fast evolution and are consistent with "RNA world" hypothesis. The discussed method is general and can be used to characterize evolution of more specific biological organism functions and relate functions to genetic structures. The derived general limitations indicate that a co-evolution of multiple functions and species could be a slow process, whereas an evolution of a specific function might proceed very fast, so that no trace of intermediate forms (species) is preserved in fossil records of phenotype or DNA structure; this is consistent with a picture of "punctuated equilibrium". PMID:12023805

  10. Generalized Geometric Quantum Speed Limits

    Science.gov (United States)

    Pires, Diego Paiva; Cianciaruso, Marco; Céleri, Lucas C.; Adesso, Gerardo; Soares-Pinto, Diogo O.

    2016-04-01

    The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  11. Impossibility - The Limits of Science and the Science of Limits

    Science.gov (United States)

    Barrow, John D.

    1999-10-01

    In Impossibility , John D. Barrow--one of our most elegant and accomplished science writers--argues convincingly that there are limits to human discovery, that there are things that are ultimately unknowable, undoable, or unreachable. Barrow first examines the limits of the human mind: our brain evolved to meet the demands of our immediate environment, and much that lies outside this small circle may also lie outside our understanding. He investigates practical impossibilities, such as those imposed by complexity, uncomputability, or the finiteness of time, space, and resources. Is the universe finite or infinite? Can information be transmitted faster than the speed of light? The book also examines deeper theoretical restrictions on our ability to know, including Godel's theorem, which proved that there were things that could not be proved. Finally, having explored the limits imposed on us from without, Barrow considers whether there are limits we should impose upon ourselves. Weaving together this intriguing tapestry, Barrow illuminates some of the most profound questions of science, from the possibility of time travel to the very structure of the universe.

  12. Ultimate physical limits to computation

    CERN Document Server

    Lloyd, S

    1999-01-01

    Computers are physical systems: what they can and cannot do is dictated by the laws of physics. In particular, the speed with which a physical device can process information is limited by its energy, and the amount of information that it can process is limited by the number of degrees of freedom it possesses. The way in which it processes information is determined by the forces of nature that the computer has at its disposal. This paper explores the fundamental physical limits of computation as determined by the speed of light c, the quantum scale as given by Planck's constant h, and the gravitational constant G. As an example, quantitative bounds are put to the computational power of an `ultimate laptop' with a mass of one kilogram confined to a volume of one liter.

  13. Limitations on quantum key repeaters.

    Science.gov (United States)

    Bäuml, Stefan; Christandl, Matthias; Horodecki, Karol; Winter, Andreas

    2015-04-23

    A major application of quantum communication is the distribution of entangled particles for use in quantum key distribution. Owing to noise in the communication line, quantum key distribution is, in practice, limited to a distance of a few hundred kilometres, and can only be extended to longer distances by use of a quantum repeater, a device that performs entanglement distillation and quantum teleportation. The existence of noisy entangled states that are undistillable but nevertheless useful for quantum key distribution raises the question of the feasibility of a quantum key repeater, which would work beyond the limits of entanglement distillation, hence possibly tolerating higher noise levels than existing protocols. Here we exhibit fundamental limits on such a device in the form of bounds on the rate at which it may extract secure key. As a consequence, we give examples of states suitable for quantum key distribution but unsuitable for the most general quantum key repeater protocol.

  14. On Setting Limits for Supersymmetry

    Science.gov (United States)

    Simeon, Paul; Toback, David

    2004-10-01

    When searching for new particles two separate production mechanisms from the same theory may produce the same final state. For example, in gauge mediated supersymmetry breaking with \\chi^0_1arrow γ tildeG at least two production mechanisms, \\chi^0_1\\chi^±1 and \\chi^0_2\\chi^±_1, can cascade to produce events with two photons and missing transverse energy. If there is no discovery one wants to set the best possible limits. While it seems obvious that the goal is to find the lowest possible cross section limit, one should be careful and focus on excluding the largest amount of parameter space for a theory. We show that the combined cross section limit from both (or all) production mechanisms that produce the same final state is the most sensitive way to attempt to exclude a theory.

  15. Shrinkage limit of soil mixtures

    International Nuclear Information System (INIS)

    Shrinkage limit, one of the Atterberg limits, is widely linked with many plasticity-based soil behaviors. However, in a great majority of these cases, such correlations have been found to exhibit poor performance. Recently, it has been brought out that the shrinkage limit of a natural soil does not depend upon plasticity characteristics, and it is primarily governed by the relative grain size distribution of the soil. The present study confirms this mechanism with the results obtained using clay-clay, clay-non-cohesive soil, and non-cohesive soil mix systems. The present study gains importance from the point of view of criteria with respect to the design of back fill materials to be used in various applications, such as nuclear waste disposal projects

  16. An exact limit of ABJM

    CERN Document Server

    Bianchi, Marco S

    2016-01-01

    We study planar ABJM in a limit where one coupling is negligible compared to the other. We provide a recipe for exactly solving the expectation value of bosonic BPS Wilson loops on arbitrary smooth contours, or the leading divergence for cusped ones, using results from localization. As an application, we compute the exact (generalized) cusp anomalous dimension and Bremsstrahlung function and use it to determine the interpolating $h$-function. We finally prove a conjecture on the exact form of the dilatation operator in a closed sector, hinting at the integrability of this limit.

  17. Reconnectable Network with Limited Resources

    Institute of Scientific and Technical Information of China (English)

    史维更

    1991-01-01

    The reachability of a strongly connected network may be destroyed after link damage.Since many networks are directed or equivalent directed,connected by directed links with the potential for reversal.Therefore the reachability can be restored by reversing the direction of links.[1] has studied this matter under unlimited resources (transmitter and receiver) condition.In this paper the reconnectability of a network with limited number of receivers and transmitters is discussed.Also a linear time algorithm is given to find a reconnected reversal for limited receivers and transmitters.

  18. Energy-limited escape revised

    OpenAIRE

    Salz, M.; Schneider, P. C.; Czesla, S.; Schmitt, J. H. M. M.

    2015-01-01

    Gas planets in close proximity to their host stars experience photoevaporative mass loss. The energy-limited escape concept is generally used to derive estimates for the planetary mass-loss rates. Our photoionization hydrodynamics simulations of the thermospheres of hot gas planets show that the energy-limited escape concept is valid only for planets with a gravitational potential lower than $\\log_\\mathrm{10}\\left( -\\Phi_{\\mathrm{G}}\\right) < 13.11~$erg$\\,$g$^{-1}$ because in these planets th...

  19. Penser aux/les limites de nos limites

    Directory of Open Access Journals (Sweden)

    Jacques Lévy

    2010-12-01

    Full Text Available Le mot « frontière » a beaucoup de succès, dans son sens propre mais plus encore comme métaphore d’une multitude de réalités qui ont à voir avec les limites, c’est-à-dire avec notre propension à découper le monde en objets séparables. Mais on constate une grande indétermination entre concept et métaphore et un usage trop facile de mélanges entre ceux-ci. Il faut donc d’abord admettre que la matérialité n’est qu’une des composantes de notre monde, mais que l’immatériel n’est pas l’irréel, le simulé ou le métaphorique. Après un détour par une théorie des limites et ses limites et une distinction entre le topographique (continu et le topologique (discontinu appliquée à l’intérieur et aux limites d’une aire, deux exemples sont développés qui visent à montrer que, si l’on trouve des frontières, ce n’est pas forcément là où on les attend et que l’appréciation juste de la place des frontières suppose la prise en compte de bien d’autres considérations que la seule limitation volontaire et brutale du franchissement d’une ligne imaginaire tracée au sol.Think about limits and the limits of our limitsThe word “boundary” has been very successful in its literal sense but even more so as a metaphor of a multitude of realities involving limits, that is, with regards to our tendency to divide the world into separable objects. However, one can observe a considerable uncertainty between the concept and the metaphor and an utilisation too easy of various mixtures of them. It becomes necessary therefore to first admit that materiality is only one of the components of our world whilst the immaterial is not unreal, simulated or metaphoric. After a detour consisting of examining a theory of limits and its limits and making the distinction between the topographic (continuous and the topologic (discontinuous applied to the interior and the limits of an area, two examples are developed which aim to

  20. ITER operating limit definition criteria

    Energy Technology Data Exchange (ETDEWEB)

    Ciattaglia, S. [EFDA-CSU Boltzmannstrasse 2, D-85748 Garching (Germany)], E-mail: sergio.ciattaglia@tech.efda.org; Barabaschi, P. [EFDA-CSU Boltzmannstrasse 2, D-85748 Garching (Germany); Carretero, J.A. [Empresarios Agrupados, Magallanes, 3 28015 Madrid (Spain); Chiocchio, S. [JWS Garching, Boltzmannstrasse 2, D-85748 Garching (Germany); Hureau, D. [AREVA NP, Tour AREVA, 92084 - Paris, La Defense Cedex (France); Girard, J.Ph.; Gordon, C. [ITER-JWS, Cadarache, St Paul Lez Durance F-13108 (France); Portone, A. [EFDA-CSU Boltzmannstrasse 2, D-85748 Garching bei Muenchen (Germany); Rodrigo, L. Rodriguez [EFDA CSU C/JosepPla, n 2, Torres Diagonal Litoral, Bldg B3. E-08019-Barcelona (Spain); Roldan, C. [CIEMAT, Avd. Complutense, 22-E-28040 Madrid (Spain); Saibene, G. [EFDA-CSU Boltzmannstrasse 2, D-85748 Garching (Germany); Uzan-Elbez, J. [Agence ITER-France, Cadarache, St Paul Lez Durance F-13108 (France)

    2009-12-15

    The operating limits and conditions (OLCs) are operating parameters and conditions, chosen among all system/components, which, together, define the domain of the safe operation of ITER in all foreseen ITER states (operation, maintenance, commissioning). At the same time they are selected to guarantee the required operation flexibility which is a critical factor for the success of an experimental machine such as ITER. System and components that are important for personnel or public safety (safety important class, SIC) are identified considering their functional importance in the overall plant safety analysis. SIC classification has to be presented already in the preliminary safety analysis report and approved by the licensing authority before manufacturing and construction. OLCs comprise the safety limits that, if exceeded, could result in a potential safety hazard, the relevant settings that determine the intervention of SIC systems, and the operational limits on equipment which warn against or stop a functional deviation from a planned operational status that could challenge equipment and functions. Some operational conditions, e.g. in-Vacuum Vessel (VV) radioactive inventories, will be controlled through procedures. Operating experience from present tokamaks, in particular JET, and from nuclear plants, is considered to the maximum possible extent. This paper presents the guidelines for the development of the ITER OLCs with particular reference to safety limits.

  1. Global limits of gauged supergravity

    NARCIS (Netherlands)

    Hohm, Olaf

    2009-01-01

    World-volume actions for multiple M2 and D2 branes are constructed by taking the limit of 2 + 1 dimensional gauged supergravities to globally supersymmetric N = 8 theories on flat space. The embedding tensor formalism adopted for the classification of gauged supergravities is thereby shown to provid

  2. Limitations of Agile Software Processes

    OpenAIRE

    Turk, Dan; France, Robert; Rumpe, Bernhard

    2014-01-01

    Software developers and project managers are struggling to assess the appropriateness of agile processes to their development environments. This paper identifies limitations that apply to many of the published agile processes in terms of the types of projects in which their application may be problematic.

  3. Aluminum honeycomb impact limiter study

    Energy Technology Data Exchange (ETDEWEB)

    Yaksh, M.C.; Thompson, T.C. (Nuclear Assurance Corp., Norcross, GA (United States)); Nickell, R.E. (Applied Science and Technology, Inc., Poway, CA (United States))

    1991-07-01

    Design requirements for a cask transporting radioactive materials must include the condition of the 30-foot free fall of the cask onto an unyielding surface. To reduce the deceleration loads to a tolerable level for all the components of the cask, a component (impact limiter) is designed to absorb the kinetic energy. The material, shape, and method of attachment of the impact limiter to the cask body comprises the design of the impact limiter. The impact limiter material of interest is honeycomb aluminum, and the particular design examined was for the NAC Legal Weight Truck cask (NAC-LWT) for spent fuel from light water reactors. The NAC-LWT has a design weight of 52,000 pounds, and it has a nominal length of 200 inches. The report describes the numerical calculations embodied in the FADE program to determine the accelerations and crush strain resulting from an arbitrary height and angle of orientation. Since the program serves as a design tool, static tests are performed to assess the effect of the shell containing the honeycomb aluminum. The static tests and their results are contained in the study. The static tests are used to demonstrate for licensing purposes the level of accelerations imposed on the cask during a 30-foot drop. 3 refs., 41 figs., 15 tabs.

  4. Games With Limited Communication Structure

    NARCIS (Netherlands)

    Talman, A.J.J.; Yamamoto, Y.

    2007-01-01

    In this paper we consider cooperative transferable utility games with limited communication structure, called graph games. Agents are able to cooperate with each other only if they can communicate directly or indirectly with each other. For the class of acyclic graph games recently the average tree

  5. Economic Downturn Limits Conference Travel

    Science.gov (United States)

    Young, Jeffrey R.

    2009-01-01

    Attendance is down at many academic and professional conferences in higher education this year, and next year's numbers are expected to be far worse, as campus budgets take further beatings. With many colleges limiting travel to professors or administrators who are speaking at events they are attending, will anyone be left in the audience? A new…

  6. Historical Drawbacks of Limited Liability

    Directory of Open Access Journals (Sweden)

    Denis Boyle

    2016-07-01

    Full Text Available Limited liability is a human invention which has facilitated enormous economic growth around the world, particularly since the time of its general application in advanced countries during the nineteenth century. The individual legal identity of companies, coupled with the limited liability of their owners, has provided protection for investors from the risks associated with their investments. It has thus contributed to increase the sources of capital available to finance projects which might otherwise have been considered unviable. However, the legal protection offered to investors has negative consequences for other participants in economies. Speculation in stock markets often damages society. It is very important to study the drawbacks of limited liability and to suggest modifications to achieve a more stable, less volatile, economic growth in the world. Although this article goes to some lengths to recognise the work of authors who emphasise the positive historical economic contribution of limited lability, its main objective is to provoke a reflection around texts which point out the drawbacks and propose solutions.

  7. Explosion limits for combustible gases

    Institute of Scientific and Technical Information of China (English)

    TONG Min-ming; WU Guo-qing; HAO Ji-fei; DAI Xin-lian

    2009-01-01

    Combustible gases in coal mines are composed of methane, hydrogen, some multi-carbon alkane gases and other gases. Based on a numerical calculation, the explosion limits of combustible gases were studied, showing that these limits are related to the concentrations of different components in the mixture. With an increase of C4H10 and C6H14, the Lower ExplosionLimit (LEL) and Upper Explosion-Limit (UEL) of a combustible gas mixture will decrease clearly. For every 0.1% increase in C4H10 and C6H14, the LEL decreases by about 0.19% and the UEL by about 0.3%. The results also prove that, by increasing the amount of H2, the UEL of a combustible gas mixture will increase considerably. If the level of H2 increases by 0.1%, the UEL will increase by about 0.3%. However, H2 has only a small effect on the LEL of the combustible gas mixture. Our study provides a theoretical foundation for judging the explosion risk of an explosive gas mixture in mines.

  8. Illustrating the Central Limit Theorem

    Science.gov (United States)

    Corcoran, Mimi

    2016-01-01

    Statistics is enjoying some well-deserved limelight across mathematics curricula of late. Some statistical concepts, however, are not especially intuitive, and students struggle to comprehend and apply them. As an AP Statistics teacher, the author appreciates the central limit theorem as a foundational concept that plays a crucial role in…

  9. Active inrush-current limiter

    Science.gov (United States)

    Kichak, R. A.

    1977-01-01

    By stretching turn-on time from approximately 1 to 200 ms, effects of inrush current (and of associated large current spikes) and current rate of rise (dl/dt) are made potentially less severe. Limiter arrangement consists of time-variable impedance connected in series between input dc power source return and power circuit of converter.

  10. Globalization and limit to growth

    International Nuclear Information System (INIS)

    A global financial crisis is not the only concern the world should have. From oil and other commodities new challenges arise, that could be difficult to face properly and could provide another limit to growth. This Malthusian feature of the 21. century emerges clearly if one focuses on climate change.

  11. Fano-noise-limited CCDs

    Science.gov (United States)

    Janesick, James; Elliott, Tom; Bredthauer, Richard; Chandler, Charles; Burke, Barry

    1988-01-01

    Recent developments of scientific CCDs have produced sensors that achieve ultra low read noise performance (less than 2 electrons rms) and near perfect charge transfer efficiency (0.9999996) without the addition of a fat-zero. This progress has now made it possible to achieve Fano-noise-limited performance in the soft X-ray where the detector's energy resolution is primarily limited by the statistical variation in the charge generated by the interacting X-ray photon. In this paper, Fano-noise-limited test data is presented for two different CCD types and a CCD derived estimate of the Fano factor is determined. By evaluating ultra low-modulation images (less than 1 electron peak-to-peak) it is shown that the CCD's global CTE is now superior to its read noise floor. To capitalize on this capability CCD manufacturers are now focusing their attention on reducing the noise floor below the 1 electron level thereby matching the sensor's CTE performance. This improvement, if accomplished, will push Fano-noise-limited performance for the CCD into the extreme ultra-violet.

  12. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs ref

  13. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs refer

  14. Limits of time in cosmology

    CERN Document Server

    Rugh, Svend E

    2016-01-01

    We provide a discussion of some main ideas in our project about the physical foundation of the time concept in cosmology. It is standard to point to the Planck scale (located at $\\sim 10^{-43}$ seconds after a fictitious "Big Bang" point) as a limit for how far back we may extrapolate the standard cosmological model. In our work we have suggested that there are several other (physically motivated) interesting limits -- located at least thirty orders of magnitude before the Planck time -- where the physical basis of the cosmological model and its time concept is progressively weakened. Some of these limits are connected to phase transitions in the early universe which gradually undermine the notion of 'standard clocks' widely employed in cosmology. Such considerations lead to a 'scale problem' for time which becomes particularly acute above the electroweak phase transition (before $\\sim 10^{-11}$ seconds). Other limits are due to problems of building up a cosmological reference frame, or even contemplating a s...

  15. 78 FR 37930 - Lending Limits

    Science.gov (United States)

    2013-06-25

    ... assets. The interim final rule amended part 32 to provide national banks and savings associations with... credit risk management practices by clearing member banks, makes it unlikely that applying the rule to... revisions. The interim final rule consolidated the lending limits rules applicable to national banks...

  16. Detection limits for radioactivity counting

    OpenAIRE

    Manić G.; Manić Vesna M.; Vesić D.

    2005-01-01

    In this paper, the detection limits for radioactivity counting are determined. Several decision rules are presented and applied to calculate the critical value. The value obtained by the best approximation for the alpha particles counting was used to evaluate the minimum detectable concentration in water, soil and air.

  17. Detection limits for radioactivity counting

    Directory of Open Access Journals (Sweden)

    Manić G.

    2005-01-01

    Full Text Available In this paper, the detection limits for radioactivity counting are determined. Several decision rules are presented and applied to calculate the critical value. The value obtained by the best approximation for the alpha particles counting was used to evaluate the minimum detectable concentration in water, soil and air.

  18. Setting time limits on tests

    NARCIS (Netherlands)

    Linden, van der Wim J.

    2011-01-01

    It is shown how the time limit on a test can be set to control the probability of a test taker running out of time before completing it. The probability is derived from the item parameters in the lognormal model for response times. Examples of curves representing the probability of running out of ti

  19. Limitation and life in space

    Science.gov (United States)

    Israel, Marvin; Smith, T. Scott

    1986-08-01

    ``The Earth is the very quintescence of the human condition...,'' says Hannah Arendt. Georg Simmel writes: ``The stranger is by nature no `owner of soil'—soil not only in the physical, but also in the figurative sense of a life-substance which is fixed, if not in a point in space, at least in an ideal point of social environment.'' How will no longer being Earthbound affect persons' experience of themselves and of others? Space colonization offers an opportunity for new self-definition by the alteration of existing limits. Thus ``limitation'' is a useful concept for exploring the physical, social and psychological significance of the colonization of space. Will people seek the security of routine, of convention, of hierarchy as in the military model governing our present-day astronauts? or will they seek to maximize the freedom inherent in extraordinary living conditions—as bohemians, deviants, travelers?

  20. Binary optics: Trends and limitations

    Science.gov (United States)

    Farn, Michael W.; Veldkamp, Wilfrid B.

    1993-08-01

    We describe the current state of binary optics, addressing both the technology and the industry (i.e., marketplace). With respect to the technology, the two dominant aspects are optical design methods and fabrication capabilities, with the optical design problem being limited by human innovation in the search for new applications and the fabrication issue being limited by the availability of resources required to improve fabrication capabilities. With respect to the industry, the current marketplace does not favor binary optics as a separate product line and so we expect that companies whose primary purpose is the production of binary optics will not represent the bulk of binary optics production. Rather, binary optics' more natural role is as an enabling technology - a technology which will directly result in a competitive advantage in a company's other business areas - and so we expect that the majority of binary optics will be produced for internal use.

  1. Quantum Diffusion-Limited Aggregation

    CERN Document Server

    Johnson, David B

    2011-01-01

    Though classical random walks have been studied for many years, research concerning their quantum analogues, quantum random walks, has only come about recently. Numerous simulations of both types of walks have been run and analyzed, and are generally well-understood. Research pertaining to one of the more important properties of classical random walks, namely, their ability to build fractal structures in diffusion-limited aggregation, has been particularly noteworthy. However, only now has research begun in this area in regards to quantum random motion. The study of random walks and the structures they build has various applications in materials science. Since all processes are quantum in nature, it is important to consider the quantum variant of diffusion-limited aggregation. Recognizing that Schr\\"odinger equation and a classical random walk are both diffusion equations, it is possible to connect and compare them. Using similar parameters for both equations, we ran various simulations aggregating particles....

  2. Containing Internal Diffusion Limited Aggregation

    CERN Document Server

    Duminil-Copin, Hugo; Yadin, Ariel; Yehudayoff, Amir

    2011-01-01

    Internal Diffusion Limited Aggregation (IDLA) is a model that describes the growth of a random aggregate of particles from the inside out. Shellef proved that IDLA processes on supercritical percolation clusters of integer-lattices fill Euclidean balls, with high probability. In this article, we complete the picture and prove a limit-shape theorem for IDLA on such percolation clusters, by providing the corresponding upper bound. The technique to prove upper bounds is new and robust: it only requires the existence of a "good" lower bound. Specifically, this way of proving upper bounds on IDLA clusters is more suitable for random environments than previous ways, since it does not harness harmonic measure estimates.

  3. Swimming as a limit cycle

    CERN Document Server

    Jacobs, Henry O

    2012-01-01

    Steady swimming can be characterized as both periodic and stable. These characteristics are the very definition of limit cycles, and so we ask "Can we view swimming as a limit cycle?" In this paper we will find that the answer is "yes". We will define a class of dissipative systems which correspond to the passive dynamics of a body immersed in a Navier-Stokes fluid (i.e. the dynamics of a dead fish). Upon performing reduction by symmetry we will find a hyperbolically stable fixed point which corresponds to the stability of a dead fish in stagnant water. Given a periodic force on the shape of the body we will invoke the persistence theorem to assert the existence of a loop which approximately satisfies the exact equations of motion. If we lift this loop with a phase reconstruction formula we will find that the lifted loops are not loops, but stable trajectories which represent regular periodic motion reminiscent of swimming.

  4. Mesures à la limite quantique

    OpenAIRE

    Heidmann, Antoine

    2007-01-01

    Doctoral Bien que les principes de base de la mesure en mécanique quantique soient connus depuis longtemps, ce n'est que récemment que les expériences ont été confrontées à ses conséquences. Les effets d'action en retour de la mesure et les limites quantiques associées sont aujourd'hui des notions essentielles dans un certain nombre d'expériences ultrasensibles, et la possibilité d'aller au-delà de ces limites par différentes techniques de compression du bruit ou de mesure non destructive ...

  5. Penrose Limits and Spacetime Singularities

    CERN Document Server

    Blau, Matthias; O'Loughlin, M; Papadopoulos, G; Blau, Matthias; Borunda, Monica; Loughlin, Martin O'; Papadopoulos, George

    2003-01-01

    We give a covariant characterisation of the Penrose plane wave limit: the plane wave profile matrix $A(u)$ is the restriction of the null geodesic deviation matrix (curvature tensor) of the original spacetime metric to the null geodesic, evaluated in a comoving frame. We also consider the Penrose limits of spacetime singularities and show that for a large class of black hole, cosmological and null singularities (of Szekeres-Iyers ``power-law type''), including those of the FRW and Schwarzschild metrics, the result is a singular homogeneous plane wave with profile $A(u)\\sim u^{-2}$, the scale invariance of the latter reflecting the power-law behaviour of the singularities.

  6. Summary of Dissolved Concentration Limits

    Energy Technology Data Exchange (ETDEWEB)

    Yueting Chen

    2001-06-11

    According to the Technical Work Plan titled Technical Work Plan for Waste Form Degradation Process Model Report for SR (CRWMS M&O 2000a), the purpose of this study is to perform abstractions on solubility limits of radioactive elements based on the process-level information and thermodynamic databases provided by Natural Environment Program Operations (NEPO) and Waste Package Operations (WPO). The scope of this analysis is to produce solubility limits as functions, distributions, or constants for all transported radioactive elements identified by the Performance Assessment Operations (PAO) radioisotope screening. Results from an expert elicitation for solubility limits of most radioactive elements were used in the previous Total System Performance Assessments (TSPAs). However, the elicitation conducted in 1993 does not meet the criteria set forth by the U.S. Nuclear Regulatory Commission (NRC) due to lack of documentation and traceability (Kotra et al. 1996, Section 3). Therefore, at the Waste Form Abstraction Workshop held on February 2-4, 1999, at Albuquerque, New Mexico, the Yucca Mountain Site Characterization Project (YMP) decided to develop geochemical models to study solubility for the proposed Monitored Geologic Repository. WPO/NEPO is to develop process-level solubility models, including review and compilation of relevant thermodynamic data. PAO's responsibility is to perform abstractions based on the process models and chemical conditions and to produce solubility distributions or response surfaces applicable to the proposed repository. The results of this analysis and conceptual model will feed the performance assessment for Total System Performance Assessment--Site Recommendation (TSPA-SR) and Total System Performance Assessment--License Application (TSPA-LA), and to the Waste Form Degradation Process Model Report section on concentration limits.

  7. Fiscal Limits in Advanced Economies

    OpenAIRE

    Eric M. Leeper; Walker, Todd B

    2011-01-01

    Aging populations in advanced economies are placing ever-increasing demands on government spending in the form of old-age benefits. Economies that have promised substantially more benefits than they have made provision to finance are heading into a prolonged era of fiscal stress. Unresolved fiscal stress raises the possibility that the economies will hit their fiscal limits where taxes and spending no longer adjust to stabilize debt. In such economies, monetary policy may lose its ability to ...

  8. Limit laws for exponential families

    OpenAIRE

    Balkema, August A.; Klüppelberg, Claudia; Resnick, Sidney I.

    1999-01-01

    For a real random variable [math] with distribution function [math] , define ¶ [math] ¶ The distribution [math] generates a natural exponential family of distribution functions [math] , where ¶ [math] ¶ We study the asymptotic behaviour of the distribution functions [math] as [math] increases to [math] . If [math] then [math] pointwise on [math] . It may still be possible to obtain a non-degenerate weak limit law [math] by choosing suitable scaling and centring constants [math] an...

  9. Protection limits on free speech

    Institute of Scientific and Technical Information of China (English)

    李敏

    2014-01-01

    Freedom of speech is one of the basic rights of citizens should receive broad protection, but in the real context of China under what kind of speech can be protected and be restricted, how to grasp between state power and free speech limit is a question worth considering. People tend to ignore the freedom of speech and its function, so that some of the rhetoric cannot be demonstrated in the open debates.

  10. Goniometry in limited joint mobility

    OpenAIRE

    Gopinath, S.; Manoj, K.; Rubiya

    2012-01-01

    Aim: To study about the utility of goniometry in screening for limited joint mobility (LJM) in patients attending a secondary level Diabetic Clinic. Materials and Methods: Randomly selected data of 100 patients attending a secondary level diabetic clinic without any complications were used. Baseline neuropathy assessments, namely monofilament and biothesiometry were done. Range of movement around the ankle joint and 1 st metatarsal joint was done using goniometry. Both the results were compar...

  11. Tiling Spaces are Inverse Limits

    OpenAIRE

    Sadun, Lorenzo

    2002-01-01

    Let M be an arbitrary Riemannian homogeneous space, and let Omega be a space of tilings of M, with finite local complexity (relative to some symmetry group Gamma) and closed in the natural topology. Then Omega is the inverse limit of a sequence of compact finite-dimensional branched manifolds. The branched manifolds are (finite) unions of cells, constructed from the tiles themselves and the group Gamma. This result extends previous results of Anderson and Putnam, of Ormes, Radin and Sadun, of...

  12. Computation Beyond the Turing Limit

    Science.gov (United States)

    Siegelmann, Hava T.

    1995-04-01

    Extensive efforts have been made to prove the Church-Turing thesis, which suggests that all realizable dynamical and physical systems cannot be more powerful than classical models of computation. A simply described but highly chaotic dynamical system called the analog shift map is presented here, which has computational power beyond the Turing limit (super-Turing); it computes exactly like neural networks and analog machines. This dynamical system is conjectured to describe natural physical phenomena.

  13. China Rare Earth Holdings Limited

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China Rare Earth Holdings Limited is a large trans-area corporation and a public company listed in Hong Kong Stock Exchange (Name: China Rare Earth, Code: 0769), with headquarter in Hong Kong. Located on the bank of beautiful Taihu Lake, the subsidiary in Yinxing covers area of 200,000 m2. It has nearly 1,000 employees, 30% of whom are technical staffs. After self-administration and effort, the company passed ISO 9001: 2000 and ISO 14000 Certificaitons.

  14. Axions - Motivation, limits and searches

    OpenAIRE

    Raffelt, Georg G.

    2006-01-01

    The axion solution of the strong CP problem provides a number of possible windows to physics beyond the standard model, notably in the form of searches for solar axions and for galactic axion dark matter, but in a broader context also inspires searches for axion-like particles in pure laboratory experiments. We briefly review the motivation for axions, astrophysical limits, their possible cosmological role, and current searches for axions and axion-like particles.

  15. Liquid-Bridge Breaking Limits

    Science.gov (United States)

    Macner, Ashley; Steen, Paul

    2011-11-01

    Wet adhesion by liquid bridges in large arrays shows promise for use in lightweight, controllable on-demand devices. Applications include grab/release of wafer substrates, transport of micron-sized tiles for use in 3D printing and micro-dosing of personalized pharmaceutical drugs. By wetting and spreading, a drop can form a bridge and thereby ``grab'' a nearby solid substrate. By volume decrease or extension, the bridge can break. The breaking limit corresponds to bridge instability which can be predicted, knowing the static mechanical response of the bridge. Mechanical behaviors include force-volume (FV), pressure-volume (pV) and force-length (FL) responses. Instability crucially depends on the mode of failure - failure under constant-force or constant length are typical cases. We study single bridge equilibria for their breaking limits. FV diagrams for the pin-pin equal and pin-pin unequal radii boundary conditions for different bridge heights are measured in the laboratory. The FL response in the case of pin-pin equal radii is also measured. Results are compared to predictions of static theory. Static results are then used to compare to dynamical sequences where volume is driven quasistatically by syringe or an electro-osmotic pump. As the breaking limit is approached, the shape deformation accelerates leading to non-equilibrium shapes not captured by the static analysis.

  16. Application of fault current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, A.

    2007-11-30

    This report presents the results of a study commissioned by the Department for Business, Enterprise and Industry (BERR; formerly the Department of Trade and Industry) into the application of fault current limiters in the UK. The study reviewed the current state of fault current limiter (FCL) technology and regulatory position in relation to all types of current limiters. It identified significant research and development work with respect to medium voltage FCLs and a move to high voltage. Appropriate FCL technologies being developed include: solid state breakers; superconducting FCLs (including superconducting transformers); magnetic FCLs; and active network controllers. Commercialisation of these products depends on successful field tests and experience, plus material development in the case of high temperature superconducting FCL technologies. The report describes FCL techniques, the current state of FCL technologies, practical applications and future outlook for FCL technologies, distribution fault level analysis and an outline methodology for assessing the materiality of the fault level problem. A roadmap is presented that provides an 'action agenda' to advance the fault level issues associated with low carbon networks.

  17. Workshop on confidence limits. Proceedings

    International Nuclear Information System (INIS)

    The First Workshop on Confidence Limits was held at CERN on 17-18 January 2000. It was devoted to the problem of setting confidence limits in difficult cases: number of observed events is small or zero, background is larger than signal, background not well known, and measurements near a physical boundary. Among the many examples in high-energy physics are searches for the Higgs, searches for neutrino oscillations, Bs mixing, SUSY, compositeness, neutrino masses, and dark matter. Several different methods are on the market: the CLs methods used by the LEP Higgs searches; Bayesian methods; Feldman-Cousins and modifications thereof; empirical and combined methods. The Workshop generated considerable interest, and attendance was finally limited by the seating capacity of the CERN Council Chamber where all the sessions took place. These proceedings contain all the papers presented, as well as the full text of the discussions after each paper and of course the last session which was a discussion session. The list of participants and the 'required reading', which was expected to be part of the prior knowledge of all participants, are also included. (orig.)

  18. Limit theories and continuous orbifolds

    CERN Document Server

    Restuccia, Cosimo

    2013-01-01

    Relativistic QFTs are in general defined by a collection of effective actions, describing the dynamics of quantum fields at different energy scales. The consequent natural idea of a space of theories is still a rather imprecise notion, since a detailed knowledge or a classification of QFTs is out of reach. In two dimensions the situation is in a better shape: in this context CFTs are under control in many instances, and we know sequences of rational theories emerging as end-points of RG flows. The present thesis explores the behaviour of sequences of rational two-dimensional CFTs when the central charge approaches its supremum. After a review of various notions useful to study limit theories, like the concept of averaged fields and the construction of continuous orbifolds, we analyse in detail the limit of sequences of N=2 supersymmetric CFTs that are connected by RG flows. The limit is not unique, since with extended Virasoro symmetry one can choose different scalings for the labels of the spectrum in the li...

  19. Limits to the growth debate

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, L.

    The first two major studies sponsored by the club of Rome were the report of the Meadows team at MIT, The Limits to Growth, published in 1972, and the Mesarovic and Pestel report, Mankind at the Turning Point, published in 1974. When the Club of Rome met in Philadelphia in April of 1976, its pronouncements reflected a frame of mind quite different from that of 1972. Recently, Herman Kahn and his colleagues at the Hudson Institute have published The Next 200 Years, a book evidently inspired as much by antagonism to the limits-to-growth school of thought as by affirmative faith in its own vision of technological optimism. The author discusses the content of the studies and summarizes his own position in four areas. (1) While no trend of growth of anything can continue indefinitely in the real world, there are not global physical limits to economic growth within a time frame susceptible to plausible foresight or relevant to policy making. (2) In some world regions, notably South Asia and tropical Africa, population growth rates do indeed threaten to create a kind of Malthusian trap, and the rapid reduction of fertility is critically important to their development prospects and urgent in time. (3) For other parts of the world, both rates and directions of growth will be more influenced by changes in preferences for consumption and in attitudes toward production than by physical constraints, although higher energy costs and environmental pressures will also be important influences in generating such changes in growth patterns. (4) Probable changes in directions of growth will generate new and important issues in international economic and political relations, with both dangers and opportunities for the evolving world order. (MCW)

  20. Limits to Global Groundwater Consumption

    Science.gov (United States)

    Graaf, I. D.; Van Beek, R.; Sutanudjaja, E.; Wada, Y.; Bierkens, M. F.

    2015-12-01

    In regions with frequent water stress and large aquifer systems, groundwater is often used as an additional fresh water source. For many regions of the world groundwater abstraction exceeds groundwater recharge and persistent groundwater depletion occurs. The most direct effect of groundwater depletion is declining of water tables, leading to reduced groundwater discharge needed to sustain base-flow to e.g. rivers. Next to that, pumping costs increase, wells dry up and land subsidence occurs. These problems are expected to increase in the near future due to growing population and climate changes. This poses the urgent question of what the limits are of groundwater consumption worldwide. We simulate global water availability (5 arc-minute resolution, for 1960-2050) using the hydrological model PCR-GLOBWB (van Beek et al. 2011), coupled to a groundwater model based on MODFLOW (de Graaf et al. 2015), allowing for groundwater - surface water interactions. The groundwater model includes a parameterization of world's confined and unconfined aquifer systems needed for a realistic simulation of groundwater head dynamics. Water demands are included (from Wada et al. 2014). We study the limits to water consumption, focusing on locally attainable groundwater and groundwater levels critical to rivers to sustain low flows. We show an increasing trend (1960-2050) in groundwater head declines, due to increase in groundwater demand. Also, stream flow will decrease and low flow conditions will occur more frequent and will be longer in duration in the near future, especially for irrigated areas. Next to that, we provide a global overview of the years it takes until groundwater gets unattainable for e.g. a local farmer (100 m below land-surface used as a proxy), and estimate the increase in pumping cost for the near future. The results show where and when limits of groundwater consumption are reached globally.

  1. Combination trading with limit orders

    Directory of Open Access Journals (Sweden)

    Henry Schellhorn

    1997-01-01

    Full Text Available We model the exchange of commodities that are contingent upon each other, when traders place mostly limit orders. Examples include: 1 a market of financial futures where future spreads are also traded, 2 a market of mutual funds and stocks, 3 a market of options and stocks, under the viewpoint that they are both combinations of Arrow-Debreu securities. We prove that consistent prices are optimal. We develop a fixed-point algorithm to compute an optimal price and allocation. The algorithm combines ideas from contraction mapping theory and from homotopy theory. It is much faster than a traditional linear programming approach.

  2. Taming Limits with Approximate Networking

    OpenAIRE

    Qadir, Junaid; Sathiaseelan, Arjuna; Wang, Liang; Crowcroft, Jon

    2016-01-01

    Internet is the linchpin of modern society, which the various threads of modern life weave around. But being a part of the bigger energy-guzzling industrial economy, it is vulnerable to disruption. It is widely believed that our society is exhausting its vital resources to meet our energy requirements, and the cheap fossil fuel fiesta will soon abate as we cross the tipping point of global oil production. We will then enter the long arc of scarcity, constraints, and limits---a post-peak "long...

  3. Thermodynamic effects on limited cavitation

    International Nuclear Information System (INIS)

    Experimental and theoretical data are presented for limited cavitation on hemispherical-nosed bodies in water and Freon 113. The experiments were conducted with 0.25 inch and 0.50 inch diameter models over a temperature range and velocity range of 80-260 deg F and 40-130fps, respectively. In general the experimental data do not display the decrease in cavitation number with temperature as predicted by the theory. It is feld that at least part of the differences between experimental and theoretical data are due to the effects of non condensable gas, laminar separation and boundary layer transition

  4. The Limit of Large Vessels

    Institute of Scientific and Technical Information of China (English)

    Yang Peiju

    2011-01-01

    On Feb 21(st),the industry was shocked by the news that AP Moller-Maersk placed an order of 10 container ships of 18,000 TEU with the South Korean ship yards.The order brings the development of large vessels to a new climax and at the same time puts forward a series of research subjects to the industry,such as what is the limit for the development of large vessels,whether ship safety can be guaranteed,and etc.

  5. Inhomogeneous diffusion-limited aggregation

    Science.gov (United States)

    Selinger, Robin Blumberg; Nittmann, Johann; Stanley, H. E.

    1989-01-01

    It is demonstrated here that inhomogeneous diffusion-limited aggregation (DLA) model can be used to simulate viscous fingering in a medium with inhomogeneous permeability and homogeneous porosity. The medium consists of a pipe-pore square-lattice network in which all pores have equal volume and the pipes have negligible volume. It is shown that fluctuations in a DLA-based growth process may be tuned by noise reduction, and that fluctuations in the velocity of the moving interface are multiplicative in form.

  6. Food irradiation, profits and limitations

    International Nuclear Information System (INIS)

    The utility of the irradiation to overcome diverse problems of lost nutritious, it has been demonstrated in multiple investigation works, that its have confirmed the value and the inoculation of the irradiated foods. The quantity of energy applied to each food, is in function of the wanted effect. In this document a guide with respect to the practical application and the utility of the irradiation process in different foods, as well as the suggested dose average is shown. Among the limitations of the use of this technology, its are the costs and not being able to apply it to some fresh foods. (Author)

  7. Limited Attention and Discourse Structure

    CERN Document Server

    Walker, M A

    1995-01-01

    This squib examines the role of limited attention in a theory of discourse structure and proposes a model of attentional state that relates current hierarchical theories of discourse structure to empirical evidence about human discourse processing capabilities. First, I present examples that are not predicted by Grosz and Sidner's stack model of attentional state. Then I consider an alternative model of attentional state, the cache model, which accounts for the examples, and which makes particular processing predictions. Finally I suggest a number of ways that future research could distinguish the predictions of the cache model and the stack model.

  8. Flooding-limited thermal mixing

    International Nuclear Information System (INIS)

    In this paper stratification in the cold leg due to high-pressure injection in a stagnated loop of a pressurized water reactor is considered. The working hypothesis is that at high injection Froude numbers, the extent of mixing approaches a limit controlled only by the flooding condition at the cold-leg exit. Experimental data available support this hypothesis. Predictions for reactor conditions indicate a stratification of ∼ 40 degrees C. As a consequence, the downcomer plume would be rather weak (with a low Froude number) and would be expected to decay quickly

  9. Modern Cosmology: Assumptions and Limits

    Science.gov (United States)

    Hwang, Jai-Chan

    2012-06-01

    Physical cosmology tries to understand the Universe at large with its origin and evolution. Observational and experimental situations in cosmology do not allow us to proceed purely based on the empirical means. We examine in which sense our cosmological assumptions in fact have shaped our current cosmological worldview with consequent inevitable limits. Cosmology, as other branches of science and knowledge, is a construct of human imagination reflecting the popular belief system of the era. The question at issue deserves further philosophic discussions. In Whitehead's words, ``philosophy, in one of its functions, is the critic of cosmologies.'' (Whitehead 1925).

  10. CSS3 pushing the limits

    CERN Document Server

    Greig, Stephen

    2013-01-01

    Push CSS3 and your design skills to the limit-and beyond! Representing an evolutionary leap forward for CSS, CSS3 is chock-full of new capabilities that dramatically expand the boundaries of what a styling language can do. But many of those new features remain undocumented, making it difficult to learn what they are and how to use them to create the sophisticated sites and web apps clients demand and users have grown to expect. Until now. This book introduces you to all of CSS3's new and advanced features, and, with the help of dozens of real-world examples and live

  11. 36 CFR 4.21 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Speed limits. 4.21 Section 4... TRAFFIC SAFETY § 4.21 Speed limits. (a) Park area speed limits are as follows: (1) 15 miles per hour... superintendent may designate a different speed limit upon any park road when a speed limit set forth in...

  12. Performance limits of heliostat fields

    Energy Technology Data Exchange (ETDEWEB)

    Kribus, A.; Krupkin, V.; Yogev, A. [Weizmann Inst. of Science, Rehovot (Israel). Environmental Sciences and Energy Research Dept.; Spirkl, W. [Ludwig-Maximilians-Univ. Muenchen (Germany). Sektion Physik

    1998-11-01

    Geometric and thermodynamic arguments are used to derive upper limits on the performance of a solar energy collection system, consisting of an axisymmetric heliostat field, a solar tower, secondary optics and a black receiver. Performance limits on collected power, concentration, and work output are presented. Performance of tower systems with several secondary optics options is compared: tower-top Compound Parabolic Concentrator (CPC), Tailored Edge-Ray Concentrator (TERC) approximated by a cone, and Cassegrainian with ground-level CPC or Compound Elliptic Concentrator (CEC). Optimized ray tracing is used to generate the design parameters of the secondary concentrators that yield the highest optical efficiency. The results show that the tower-top Cone provides the best performance regarding both concentration and efficiency, except for very large fields. The Cassegrainian designs come in second, but become equal and even better than the Cone for large fields. The results for the Cassegrainian are sensitive to the value of the reflectivity, due to the additional reflections incurred. The choice of a CEC is better than a CPC for the terminal concentration in a Cassegrainian system, but the difference is small. The suitability of the different design options for high-temperature solar applications is discussed. The recommendations regarding optical configuration depend on field size, as well as on application-specific constraints.

  13. Hamiltonian mechanics limits microscopic engines

    Science.gov (United States)

    Anglin, James; Gilz, Lukas; Thesing, Eike

    2015-05-01

    We propose a definition of fully microscopic engines (micro-engines) in terms of pure mechanics, without reference to thermodynamics, equilibrium, or cycles imposed by external control, and without invoking ergodic theory. This definition is pragmatically based on the observation that what makes engines useful is energy transport across a large ratio of dynamical time scales. We then prove that classical and quantum mechanics set non-trivial limits-of different kinds-on how much of the energy that a micro-engine extracts from its fuel can be converted into work. Our results are not merely formal; they imply manageable design constraints on micro-engines. They also suggest the novel possibility that thermodynamics does not emerge from mechanics in macroscopic regimes, but rather represents the macroscopic limit of a generalized theory, valid on all scales, which governs the important phenomenon of energy transport across large time scale ratios. We propose experimental realizations of the dynamical mechanisms we identify, with trapped ions and in Bose-Einstein condensates (``motorized bright solitons'').

  14. Energy-limited escape revised

    CERN Document Server

    Salz, M; Czesla, S; Schmitt, J H M M

    2016-01-01

    Gas planets in close proximity to their host stars experience photoevaporative mass loss. The energy-limited escape concept is generally used to derive estimates for the planetary mass-loss rates. Our photoionization hydrodynamics simulations of the thermospheres of hot gas planets show that the energy-limited escape concept is valid only for planets with a gravitational potential lower than $\\log_\\mathrm{10}\\left( -\\Phi_{\\mathrm{G}}\\right) < 13.11~$erg$\\,$g$^{-1}$ because in these planets the radiative energy input is efficiently used to drive the planetary wind. Massive and compact planets with $\\log_\\mathrm{10}\\left( -\\Phi_{\\mathrm{G}}\\right) \\gtrsim 13.6~$erg$\\,$g$^{-1}$ exhibit more tightly bound atmospheres in which the complete radiative energy input is re-emitted through hydrogen Ly$\\alpha$ and free-free emission. These planets therefore host hydrodynamically stable thermospheres. Between these two extremes the strength of the planetary winds rapidly declines as a result of a decreasing heating eff...

  15. Measurement limits in flash thermography

    Science.gov (United States)

    Shepard, Steven M.; Lhota, James R.; Ahmed, Tasdiq

    2009-05-01

    Although active thermography has traditionally been regarded as a qualitative NDT method, its potential for quantitative measurement of thermophysical properties including wall thickness, flaw size and depth, thermal diffusivity or effusivity has been the subject of numerous investigations. Enabled by improvements in IR camera technology and fast, abundant and inexpensive computing power for advanced signal processing, measurement results have been reported using a variety of excitation and signal processing schemes. Results are often presented as a correlation between thermography data and nominal properties or independent measurements by another "validated" method. However, given the diffusion mechanism that underlies thermography, and the quantization and sampling conditions implicit in using an IR camera as a temperature sensor, there are definite limits to what can be achieved in a thermography measurement. While many benefits can be achieved with improved instrumentation, efficient energy insertion or optimized signal processing, ultimately, the limits imposed by diffusion and instrumentation take precedence, and cannot be circumvented. In this paper, the effects of camera frame rate and sensitivity on measurement of the thickness of a slab are examined, using basic 1-dimensional diffusion approximations.

  16. DC superconducting fault current limiter

    Science.gov (United States)

    Tixador, P.; Villard, C.; Cointe, Y.

    2006-03-01

    There is a lack of satisfying solutions for fault currents using conventional technologies, especially in DC networks, where a superconducting fault current limiter could play a very important part. DC networks bring a lot of advantages when compared to traditional AC ones, in particular within the context of the liberalization of the electric market. Under normal operation in a DC network, the losses in the superconducting element are nearly zero and only a small, i.e. a low cost, refrigeration system is then required. The absence of zero crossing of a DC fault current favourably accelerates the normal zone propagation. The very high current slope at the time of the short circuit in a DC grid is another favourable parameter. The material used for the experiments is YBCO deposited on Al2O3 as well as YBCO coated conductors. The DC limitation experiments are compared to AC ones at different frequencies (50-2000 Hz). Careful attention is paid to the quench homogenization, which is one of the key issues for an SC FCL. The University of Geneva has proposed constrictions. We have investigated an operating temperature higher than 77 K. As for YBCO bulk, an operation closer to the critical temperature brings a highly improved homogeneity in the electric field development. The material can then absorb large energies without degradation. We present tests at various temperatures. These promising results are to be confirmed over long lengths.

  17. Goniometry in limited joint mobility

    Directory of Open Access Journals (Sweden)

    S Gopinath

    2012-01-01

    Full Text Available Aim: To study about the utility of goniometry in screening for limited joint mobility (LJM in patients attending a secondary level Diabetic Clinic. Materials and Methods: Randomly selected data of 100 patients attending a secondary level diabetic clinic without any complications were used. Baseline neuropathy assessments, namely monofilament and biothesiometry were done. Range of movement around the ankle joint and 1 st metatarsal joint was done using goniometry. Both the results were compared. Inclusion Criteria: Selected 100 patients attending a secondary level diabetic clinic and on regular follow-up were included in the study. Exclusion Criteria: Sick patients requiring parenteral feeds, IV antibiotics, co-morbid conditions such as microvascular complication, autonomic gastroparesis, and diabetic foot infections were excluded from the study. Conclusion: Goniometric screening for LJM is a cheap and effective screening tool for detecting early structural deformity producing a higher plantar pressure and ulcer, and thereby preventing them at early stage.

  18. Mathematical methods for hydrodynamic limits

    CERN Document Server

    Masi, Anna

    1991-01-01

    Entropy inequalities, correlation functions, couplings between stochastic processes are powerful techniques which have been extensively used to give arigorous foundation to the theory of complex, many component systems and to its many applications in a variety of fields as physics, biology, population dynamics, economics, ... The purpose of the book is to make theseand other mathematical methods accessible to readers with a limited background in probability and physics by examining in detail a few models where the techniques emerge clearly, while extra difficulties arekept to a minimum. Lanford's method and its extension to the hierarchy of equations for the truncated correlation functions, the v-functions, are presented and applied to prove the validity of macroscopic equations forstochastic particle systems which are perturbations of the independent and of the symmetric simple exclusion processes. Entropy inequalities are discussed in the frame of the Guo-Papanicolaou-Varadhan technique and of theKipnis-Oll...

  19. Pericytes limit tumor cell metastasis

    DEFF Research Database (Denmark)

    Xian, Xiaojie; Håkansson, Joakim; Ståhlberg, Anders;

    2006-01-01

    Previously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions...... and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing...... the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied beta cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role...

  20. Proposition Algebra with Projective Limits

    CERN Document Server

    Bergstra, J A

    2008-01-01

    Sequential logic deviates from propositional logic by taking into account that atomic propositions yield different Boolean values at different times during the sequential evaluation of a single proposition. Reactive valuations capture this dynamics of a proposition's environment. This logic is phrased as an equationally specified algebra rather than in the form of proof rules. It is strictly more general than Boolean algebra to the extent that the classical connectives fail to be expressively complete in the sequential case. The proposition algebra PRA is developed in a fashion similar to the process algebra ACP and the program algebra PGA via an algebraic specification which has a meaningful initial algebra for which a range of courser congruences are considered important as well. In addition infinite objects (that is propositions, processes and programs respectively) are preferably dealt with by means of an inverse limit construction which allows the transfer of knowledge concerning finite objects to facts ...

  1. The Limits of Custodial Symmetry

    CERN Document Server

    Chivukula, R Sekhar; Foadi, Roshan; Simmons, Elizabeth H

    2010-01-01

    We introduce a toy model implementing the proposal of using a custodial symmetry to protect the Z b_L bbar_L coupling from large corrections. This "doublet-extended standard model" adds a weak doublet of fermions (including a heavy partner of the top quark) to the particle content of the standard model in order to implement an O(4) x U(1)_X = SU(2)_L x SU(2)_R x P_LR x U(1)_X symmetry in the top-quark mass generating sector. This symmetry is softly broken to the gauged SU(2)_L x U(1)_Y electroweak symmetry by a Dirac mass M for the new doublet; adjusting the value of M allows us to explore the range of possibilities between the O(4)-symmetric (M to 0) and standard-model-like (M to infinity) limits.

  2. The Limits of Custodial Symmetry

    CERN Document Server

    Chivukula, R Sekhar; Foadi, Roshan; Simmons, Elizabeth H

    2010-01-01

    We introduce a toy model implementing the proposal of using a custodial symmetry to protect the Zbb coupling from large corrections. This "doublet-extended standard model" adds a weak doublet of fermions (including a heavy partner of the top quark) to the particle content of the standard model in order to implement an O(4) x U(1)_X = SU(2)_L x SU(2)_R x P_{LR} x U(1)_X symmetry that protects the Zbb coupling. This symmetry is softly broken to the gauged SU(2)_L x U(1)_Y electroweak symmetry by a Dirac mass M for the new doublet; adjusting the value of M allows us to explore the range of possibilities between the O(4)-symmetric (M to 0) and standard-model-like (M to infinity) limits.

  3. THE LIMITS OF ESP TESTS

    Directory of Open Access Journals (Sweden)

    Norica-Felicia BUCUR

    2015-07-01

    Full Text Available Global market forces have determined not only higher education institutions all over the world to include ESP courses in their curriculum to enhance their students’ future employability, but also public and private organisations to offer their employees the opportunity to attend ESP courses in order to meet the continuously growing ESP needs. From this perspective, ESP compentence could become a subcomponent of one of the key competences for lifelong learning, communication in foreign languages. Therefore assessing ESP competence seems to acquire paramount importance since stakeholders need accurate information about the ESP learners’ abilities to cope with specific language tasks. This article offers a concise overview of the principles and practices of ESP assessment, a detailed description of the features of ESP tests, while focusing particularly on the limits of ESP tests in order to identify possible solutions to overcome them.

  4. Quantum parallelism may be limited

    CERN Document Server

    Ozhigov, Yu I

    2016-01-01

    We consider quantum formalism limited by the classical simulating computer with the fixed memory. The memory is redistributed in the course of modeling by the variation of the set of classical states and the accuracy of the representation of amplitudes. This computational description completely preserves the conventional formalism and does not contradicts to experiments, but it makes impossible fast quantum algorithms. This description involves the slow down of quantum evolutions with the growth of the dimension of the minimal subspace containing entangled states, which arise in the evolution. This slow down is the single difference of the proposed formalism from the standard one; it is negligible for the systems from the usual experiments, including those in which many entangled particle participate, but grows rapidly in the attempt to realize the scalable quantum computations, which require the unlimited parallelism. The experimental verification of this version of quantum formalism is reduced to the fixati...

  5. Extremal Limits and Kerr Spacetime

    CERN Document Server

    Pradhan, Parthapratim

    2013-01-01

    We study Innermost Stable Circular Orbits (ISCO) in extremal Kerr spacetime which lie close (in terms of the radial coordinate) to the event horizon and compare these with similar orbits in the near-extremal situation. Extremization of the effective potential for timelike circular orbits shows the existence of a stable circular geodesics in the extremal spacetime, precisely {\\it on} the event horizon in terms of the radial coordinate. This type of geodesics is unstable in the corresponding near-extremal spacetime as we show here, testifying to differences between the extremal limit of a generic Kerr spacetime and the exactly extremal geometry. Another aspect of the extremization of the effective potential for null circular orbits shows the existence of an unstable circular geodesic due to the axisymmetry of the spacetime in the extremal Kerr black hole. We attempt to relate this to the fact that the extremal Kerr black hole spacetime possesses no outer trapped surface.

  6. Collider limits on leptophilic interactions

    Energy Technology Data Exchange (ETDEWEB)

    Aguila, Francisco del; Yamamoto, Yasuhiro [Granada Univ. (Spain). CAFPE; Granada Univ. (Spain). Dept. de Fisica Teorica y del Cosmos; Chala, Mikael [Granada Univ. (Spain). CAFPE; Granada Univ. (Spain). Dept. de Fisica Teorica y del Cosmos; Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Santiago, Jose [Granada Univ. (Spain). CAFPE; Granada Univ. (Spain). Dept. de Fisica Teorica y del Cosmos; European Organization for Nuclear Research (CERN), Geneva (Switzerland)

    2014-11-15

    In order to observe leptophilic interactions at the LHC we must require at least four leptons, which may be in particular neutrinos, in the final state. If they are mediated by a resonance in the di-leptonic channel, this must be of spin 1 to be produced through a renormalizable coupling. We study the LHC reach for such a vector boson allowing for arbitrary couplings, what in practice means for arbitrary couplings to muons because lepton flavor violating couplings are constrained by rare processes, couplings to electrons by LEP and LHC is not sensitive to final states involving taus in this case. This makes the ILC complementary as it will provide the best limits on Z' couplings to tau leptons. A prominent example is the case of the anomaly-free Z' coupling to the muon minus tau lepton number L{sub μ}-L{sub τ}. If no departure from the Standard Model is observed at the LHC, the most stringent bounds on this vector boson are provided from events with only three charged leptons plus missing energy. Masses of the order of 1 TeV can be probed at the high-luminosity phase of the LHC for Z' couplings of order one. Generic four-lepton operators parametrizing leptophilic interactions can be also restricted using three and four (or two at the ILC) charged lepton samples, but the corresponding limits are marginal, if meaningful, because the resonant behavior appears to be essential for the signal to be significant.

  7. Prospective Optimization with Limited Resources.

    Science.gov (United States)

    Snider, Joseph; Lee, Dongpyo; Poizner, Howard; Gepshtein, Sergei

    2015-09-01

    The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their "depth of computation") and how often they attempted to incorporate new information about the future rewards (their "recalculation period"). We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation.

  8. Pure Phase Solubility Limits: LANL

    Energy Technology Data Exchange (ETDEWEB)

    C. Stockman

    2001-01-26

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO{sub 2} partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility

  9. Pure Phase Solubility Limits: LANL

    International Nuclear Information System (INIS)

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO2 partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility products

  10. 50 CFR 660.232 - Limited entry daily trip limit (DTL) fishery for sablefish.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Limited entry daily trip limit (DTL... limit (DTL) fishery for sablefish. (a) Limited entry DTL fisheries both north and south of 36° N. lat... restrictions and limits of the limited entry daily and/or weekly trip limit (DTL) fishery for...

  11. Cost-analysis of the WHO Essential Medicines List in A Resource-Limited Setting: Experience from A District Hospital in India.

    Science.gov (United States)

    Alvarez-Uria, Gerardo; Thomas, Dixon; Zachariah, Seeba; Byram, Rajarajeshwari; Kannan, Shanmugamari

    2014-05-01

    The World Health Organization (WHO) has been publishing the essential medicines list (EML) since 1977. The EML includes the most efficacious, safe and cost-effective drugs for the most relevant public health conditions worldwide. The WHO performs a cost-effectiveness analysis within each therapeutic group, but very little is known about which therapeutic groups are costliest for hospitals that adopt the WHO EML concept. In this study, we have described the annual consumption of medicines in a district hospital in India, that limited the list of available drugs according to the WHO EML concept. Only 21 drugs constituted 50% of the hospital spending. Anti-infective medicines accounted for 41% of drug spending, especially antiretrovirals which were used to treat HIV infection. Among other therapeutic groups, insulin had the highest impact on the hospital budget. We identified medicines used in perinatal care, which included anti-D immunoglobulin and lung surfactants, that were used rarely, but bore a relatively high cost burden. The results of this study indicate that, in district that adopt the WHO EML, antiretrovirals and antibiotics were the top therapeutic groups for the drug hospital budgets. PMID:24995196

  12. IDENTIDADES MASCULINAS: LIMITES E POSSIBILIDADES

    Directory of Open Access Journals (Sweden)

    May-Lin Wang

    2006-06-01

    Full Text Available O presente trabalho toma por base uma abordagem psicossocial para discorrer sobre os limites impostos pelos estereótipos de gênero à construção de uma identidade masculina, em contraposição às possibilidades de subjetivação, num cenário cultural de pluralidade identitária. Ênfase é dada à socialização estereotipada dos meninos, num processo no qual se verifica uma espécie de superposição do contexto socio-histórico em que cresceram os pais àquele no qual o menino é socializado, acentuando determinadas crenças sobre gênero. O modelo tradicional de virilidade, que imperava inquestionável até bem pouco tempo, ignorando as necessidades afetivas e valorizando características como a competitividade, a preocupação com o desempenho, o autoritarismo, a dominação e a opressão, vem sendo questionado como pilar maior da identidade masculina tradicional.

  13. Exploring life's limits: Deep geobiochemistry

    Science.gov (United States)

    Cox, A. D.

    2014-12-01

    N-dimensional chemical space on Earth and beyond produces diverse habitats for microbial activity. Hydrothermal environments cover a wide range of habitable space up to and including life's known limits and provide a window into deep geological, geochemical, and biological processes. Hydrothermal water compositions, as sampled from and measured in terrestrial hot springs on Earth's surface, vary in chemical constituent speciation and concentrations over orders of magnitude in a plethora of geochemical parameters with biological significance, including hydronium ion, sulfide, iron, zinc, magnesium, manganese, and molybdenum. Proteins provide a link between geochemistry and microbial activity by catalyzing chemical reactions. Proteins extracted and identified by tandem mass spectrometry from 13 hot spring sediments and biofilms - covering pH values from 2-9 and diverse geochemical compositions - function as efflux transporters, permeases, electron transporters, and others, suggesting that these processes were present in the environment and occurring at the time of sampling. Metalloenzymes have been identified, including the iron protein rubrerythrin, thought to be involved in oxidative stress protection in anaerobic bacteria and archaea, as well as proteins involved in macronutrient processing (carbon, phosphorus, nitrogen, and sulfur). The melding of biochemistry with geochemistry shows potential for quantifying microbial activity in deep environments by demonstrating the presence - and as techniques improve, relative abundances - of reaction-catalyzing enzymes. Moreover, using hot spring sources and their outflow channels as chemical and biological models of geologic time helps decipher the origin and co-evolution of life and geochemistry.

  14. Agriculture: access to technology limited.

    Science.gov (United States)

    1997-01-01

    From country to country and even regionally, the roles of women in agriculture vary, but most of their labor is in unpaid subsistence production and their contributions tend to be underestimated, according to the results of the [UN] Secretary-General's report. Depending on circumstances, they have complementary roles with men, sharing or dividing tasks in the production of crops, care of animals, and forestry management. In sub-Saharan Africa, for example, women contribute 60-80% of labor in food production for both household consumption and sale, while in Malaysia the women account for only 35% of the agricultural labor force, and in Ireland the participation rate is only 10.4%. Although women make this important amount of labor contributions to agricultural production, "development policies tend to favor export crops to earn foreign exchange and the agricultural research tends to address the improvement of production and technologies for commercial production". This results in limited access for women to technical knowledge and innovations, including irrigation, machinery, farming techniques and extension services. This is strengthened by the fact that most of the extension services target farmers who own land and can obtain credit to invest in input and technology. PMID:12293737

  15. Anisotropic diffusion-limited aggregation.

    Science.gov (United States)

    Popescu, M N; Hentschel, H G E; Family, F

    2004-06-01

    Using stochastic conformal mappings, we study the effects of anisotropic perturbations on diffusion-limited aggregation (DLA) in two dimensions. The harmonic measure of the growth probability for DLA can be conformally mapped onto a constant measure on a unit circle. Here we map m preferred directions for growth to a distribution on the unit circle, which is a periodic function with m peaks in [-pi,pi) such that the angular width sigma of the peak defines the "strength" of anisotropy kappa= sigma(-1) along any of the m chosen directions. The two parameters (m,kappa) map out a parameter space of perturbations that allows a continuous transition from DLA (for small enough kappa ) to m needlelike fingers as kappa--> infinity. We show that at fixed m the effective fractal dimension of the clusters D(m,kappa) obtained from mass-radius scaling decreases with increasing kappa from D(DLA) approximately 1.71 to a value bounded from below by D(min) = 3 / 2. Scaling arguments suggest a specific form for the dependence of the fractal dimension D(m,kappa) on kappa for large kappa which compares favorably with numerical results. PMID:15244564

  16. Limits to Drift Chamber Resolution

    CERN Document Server

    Riegler, Werner

    1998-01-01

    ATLAS (A Large Toroidal LHC Apparatus) will be a general-purpose experiment at the Large Hadron Collider that will be operational at CERN in the year 2004. The ATLAS muon spectrometer aims for a momentum resolution of 10% for a transverse momentum of pT=1TeV. The precision tracking devices in the muon system will be high pressure drift tubes (MDTs) with a single wire resolution of 1100 chambers covering an area of ≈ 2500m2. The high counting rates in the spectrometer as well as the aim for excellent spatial resolution and high efficiency put severe constraints on the MDT operating parameters. This work describes a detailed study of all the resolution limiting factors in the ATLAS environment. A ’full chain’ simulation of the MDT response to photons and charged particles as well as quantitative comparisons with measurements was performed. The good agreement between simulation and measurements resulted in a profound understanding of the drift chamber processes and the individual contributions to the spat...

  17. Photon and graviton mass limits

    Energy Technology Data Exchange (ETDEWEB)

    Nieto, Michael [Los Alamos National Laboratory; Goldhaber Scharff, Alfred [SUNY

    2008-01-01

    We review past and current studies of possible long-distance, low-frequency deviations from Maxwell electrodynamics and Einstein gravity. Both have passed through three phases: (1) Testing the inverse-square laws of Newton and Coulomb, (2) Seeking a nonzero value for the rest mass of photon or graviton, and (3) Considering more degrees of freedom, allowing mass while preserving gauge or general-coordinate invariance. For electrodynamics there continues to be no sign of any deviation. Since our previous review the lower limit on the photon Compton wavelength (associated with weakening of electromagnetic fields in vacuum over large distance scale) has improved by four orders of magnitude, to about one astronomical unit. Rapid current progress in astronomical observations makes it likely that there will be further advances. These ultimately could yield a bound exceeding galactic dimensions, as has long been contemplated. Meanwhile, for gravity there have been strong arguments about even the concept of a graviton rest mass. At the same time there are striking observations, commonly labeled 'dark matter' and 'dark energy' that some argue imply modified gravity. This makes the questions for gravity much more interesting. For dark matter, which involves increased attraction at large distances, any explanation by modified gravity would be qualitatively different from graviton mass. Because dark energy is associated with reduced attraction at large distances, it might be explained by a graviton-mass-like effect.

  18. 49 CFR 218.35 - Yard limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train...

  19. The role of limiter in Egyptor Tokamak

    CERN Document Server

    Ei-Sisi, A B

    2002-01-01

    In Egyptor Tokamak, the limiter is used for separation of the plasma from the vessel. In this work an overview of limiter types, and construction of limiter in Egyptor Tokamak is discussed. Also simulation results of the radial electron density distribution in case of limiter are presented. The results of the simulation are in agreement with the experimental and analytical results.

  20. Tracial Limit of C*-algebras

    Institute of Scientific and Technical Information of China (English)

    Shan Wen HU; Hua Xin LIN; Yi Feng XUE

    2003-01-01

    A new limit of C*-algebras, the tracial limit, is introduced in this paper. We show thata separable simple C*-algebra 4 is a tracial limit of C*-algebras in Z(k) if and only if A has tracialtopological rank no more than k. We present several known results using the notion of tracial limits.

  1. Limited Deposit Insurance Coverage and Bank Competition

    OpenAIRE

    Shy, Oz; Stenbacka, Rune; Yankov, Vladimir

    2014-01-01

    Deposit insurance designs in many countries place a limit on the coverage of deposits in each bank. However, no limits are placed on the number of accounts held with different banks. Therefore, under limited deposit insurance, some consumers open accounts with different banks to achieve higher or full deposit insurance coverage. We compare three regimes of deposit insurance: No deposit insurance, unlimited deposit insurance, and limited deposit insurance. We show that limited deposit insuranc...

  2. Newtonian limits of warp drive spacetimes

    OpenAIRE

    Natario, Jose

    2004-01-01

    We find a class of warp drive spacetimes possessing Newtonian limits, which we then determine. The same method is used to compute Newtonian limits of the Schwarzschild solution and spatially flat Friedmann-Robertson-Walker cosmological models.

  3. A MODEL OF MINIMUM SIZE LIMIT REGULATIONS

    OpenAIRE

    Homans, Frances R.; Ruliffson, Jane A.

    1998-01-01

    Minimum size limits have become an increasingly popular management tool in recreational fisheries. This popularity stems from the potential of minimum size limits to accomplish the twin goals of limiting overfishing and improving fishing quality through increasing the average size of fish caught. The success of minimum size limits in achieving these objectives depends in a complicated way on both the behavior of anglers and the biological mechanisms that guide the growth of the fish populatio...

  4. 12 CFR 24.4 - Investment limits.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Investment limits. 24.4 Section 24.4 Banks and... ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.4 Investment limits. (a) Limits on aggregate outstanding investments. A national bank's aggregate outstanding investments...

  5. 36 CFR 1004.21 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Speed limits. 1004.21 Section 1004.21 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.21 Speed limits. (a) Speed limits in the area administered by the Presidio Trust are as follows: (1) 15 miles...

  6. 50 CFR 38.13 - Speed limits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Speed limits. 38.13 Section 38.13 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Prohibitions § 38.13 Speed limits. No person on Midway Atoll National Wildlife Refuge will exceed the speed limit for automobiles,...

  7. Multiple Limit Cycles in an Immune System

    Institute of Scientific and Technical Information of China (English)

    Xun-cheng Huang; Le-min Zhu; Minaya Villasana

    2008-01-01

    The nonlinear oscillatory phenomenon has been observed in the system of immune response, which corresponds to the limit cycles in the mathematical models. We prove that the system simulating an immune response studied by Huang has at least three limit cycles in the system. The conditions for the multiple limit cycles are useful in analyzing the nonlinear oscillation in immune response.

  8. 49 CFR 663.9 - Audit limitations.

    Science.gov (United States)

    2010-10-01

    ... Audit limitations. (a) An audit under this part is limited to verifying compliance with (1) Applicable... 49 Transportation 7 2010-10-01 2010-10-01 false Audit limitations. 663.9 Section 663.9... audit under this part includes, where appropriate, a copy of a manufacturer's self...

  9. 47 CFR 73.1725 - Limited time.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Limited time. 73.1725 Section 73.1725... Rules Applicable to All Broadcast Stations § 73.1725 Limited time. (a) Operation is applicable only to... stations on the channel. (b) No authorization will be granted for: (1) A new limited time station; (2)...

  10. Primordial magnetic field limits from cosmological data

    International Nuclear Information System (INIS)

    We study limits on a primordial magnetic field arising from cosmological data, including that from big bang nucleosynthesis, cosmic microwave background polarization plane Faraday rotation limits, and large-scale structure formation. We show that the physically relevant quantity is the value of the effective magnetic field, and limits on it are independent of how the magnetic field was generated.

  11. 12 CFR 616.6600 - Leasing limit.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Leasing limit. 616.6600 Section 616.6600 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LEASING § 616.6600 Leasing limit. All leases made by Farm Credit System institutions shall be subject to the lending and leasing limit in subpart...

  12. 47 CFR 80.559 - Licensing limitations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Licensing limitations. 80.559 Section 80.559... MARITIME SERVICES Operational Fixed Stations § 80.559 Licensing limitations. Operational fixed stations are subject to the following licensing limitations: (a) A maximum of four frequencies will be assigned....

  13. 47 CFR 87.451 - Licensing limitations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Licensing limitations. 87.451 Section 87.451... Operational Fixed Stations § 87.451 Licensing limitations. Operational fixed stations are subject to the following licensing limitations: (a) A maximum of four frequencies will be assigned. (b) Stations will...

  14. Optimizing discrete control systems with phase limitations

    Energy Technology Data Exchange (ETDEWEB)

    Shakhverdian, S.B.; Abramian, A.K.

    1981-01-01

    A new method is proposed for solving discrete problems of optimizing control systems with limitations on the phase coordinates. Results are given from experimental research which demonstrate the need to introduce tangential limitations independent of the method of accounting for the phase limitations.

  15. Hopf limit cycles estimation in power systems

    Energy Technology Data Exchange (ETDEWEB)

    Barquin, J.; Gomez, T.; Pagola, L.F. [Univ. Pontificia Comillas, Madrid (Spain). Inst. de Investigacion Tecnologica

    1995-11-01

    This paper addresses the computation of the Hopf limit cycle. This limit cycle is associated to the appearance of an oscillatory instability in dynamical power systems. An algorithm is proposed to estimate the dimensions and shape of this limit cycle. The algorithm is computationally efficient and is able to deal with large power systems. 7 refs, 4 figs, 1 tab

  16. 47 CFR 18.307 - Conduction limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conduction limits. 18.307 Section 18.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL INDUSTRIAL, SCIENTIFIC, AND MEDICAL EQUIPMENT Technical... conducted limits shall preclude the need to show compliance with the field strength limits below 30...

  17. 50 CFR 648.145 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession limit. 648.145 Section 648.145... Fishery § 648.145 Possession limit. (a) No person shall possess more than 25 black sea bass, in, or... that is not eligible for a black sea bass moratorium permit are subject to this possession limit....

  18. 50 CFR 648.125 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession limit. 648.125 Section 648.125... § 648.125 Possession limit. (a) No person shall possess more than 10 scup in, or harvested from, the EEZ... moratorium permit are subject to this possession limit. The owner, operator, and crew of a charter or...

  19. The density limit in JET diverted plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, D.J.; Clement, S.; Gottardi, N.; Gowers, C.; Harbour, P.; Loarte, A.; Horton, L.; Lingertat, J.; Lowry, C.G.; Saibene, G.; Stamp, M.; Stork, D. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Monk, R. [Royal Holloway Coll., London (United Kingdom). Dept. of Physics

    1994-07-01

    In JET limiter plasmas the density limit is associated with radiated power fractions of 100% and, in plasmas with carbon limiters, it is invariably disruptive. However, in discharges with solid beryllium limiters the limit is identified with the formation of a MARFE and disruptions are less frequent. In addition, the improved conditioning of the vessel arising from the use of beryllium has significantly improved the density limit scaling, so that the maximum density rises with the square root of the input power. In diverted plasmas several confinement regimes exist, making the characterization of the density limit more complex. While the density limit in L-mode plasmas is generally disruptive, the limit in ELMy and ELM-free H-modes generally prompts a return to the L-mode and a disruption is not inevitable. The density limit does rise with the increasing power, but the L-to-H transition complicates the analysis. Nevertheless, at low plasma currents (<2 MA), densities significantly above the Greenwald limit can be achieved, while at higher currents power handling limitations have constrained the range of density which can be achieved. (authors). 7 refs., 4 figs.

  20. Flux-limited diffusion with relativistic corrections

    International Nuclear Information System (INIS)

    A recently reported flux-limited diffusion theory is extended to include relativistic terms, correct to first order in the fluid velocity. We show that this diffusion theory is fully flux limited, and yields the correct result for the radiative flux in the classical diffusion limit, namely a Fick's law component plus a v/c convective term

  1. 45 CFR 3.26 - Speed limit.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Speed limit. 3.26 Section 3.26 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION CONDUCT OF PERSONS AND TRAFFIC ON THE NATIONAL INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.26 Speed limit. The speed limit is 25 miles...

  2. Rapid irreversible encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.

    Science.gov (United States)

    Christopher, Kenneth; Horkan, Clare; Barb, Ilie T; Arbelaez, Christian; Hodgdon, Travis A; Yodice, Paul C

    2004-11-01

    Intravenous Rho (D) immune globulin (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura (ITP). Common side effects of IV RhIG include mild hemolysis, febrile reaction, and headache. Significant hemolysis with renal impairment following IV RhIG has been reported. We report a case of irreversible encephalopathy 48 hr following an infusion of IV RhIG for treatment of ITP. PMID:15495245

  3. Rapid encephalopathy associated with anti-D immune globulin treatment for idiopathic thrombocytopenic purpura.

    Science.gov (United States)

    Golla, Sunitha; Horkan, Clare; Dogaru, Grigore; Teske, Thomas E; Christopher, Kenneth

    2008-01-01

    Rho (D) immune globulin intravenous (IV RhIG, WinRho SDF) has been shown to be a safe treatment for idiopathic thrombocytopenic purpura. Common side effects of IV RhIG include mild hemolysis, febrile reaction and headache. Significant hemolysis with renal impairment is infrequently noted. A single case of irreversible encephalopathy following IV RhIG has been reported. We report a second case of encephalopathy following an infusion of IV RhIG for treatment of idiopathic thrombocytopenic purpura. PMID:18957844

  4. Anti-D'Souza: The End of Racism and the Asian American [book review].

    Science.gov (United States)

    Prashad, Vijay

    1998-01-01

    Reviews Dinesh D'Souza's "The End of Racism: Principles for a Multiracial Society" (1995), exploring his neoconservative ideology in the context of concepts of the underclass and what it means to be Asian American or an immigrant. D'Souza perpetuates the Model Minority thesis, which is itself a form of inferential racism. (SLD)

  5. A case of severe haemolytic disease of the newborn due to anti-D(a) antibody

    OpenAIRE

    Ting, JY; Ma, ESK; Wong, KY

    2004-01-01

    Red cell allo-antibodies directed against the Diego (Di) blood group antigen have rarely been reported to cause a haemolytic reaction against transfusion or haemolytic disease of the newborn. The frequency of the Di(a+) phenotype among the Hong Kong Chinese population is estimated to be 4.4%. We report on a case of severe haemolytic disease of the newborn due to anti-Di(a) antibody--the first local case to the best of our knowledge. Rare but clinically significant antibodies targeting red blo...

  6. ID-DiaScreen Prophylax -seulontasolupaneeli anti-D-vasta-aineen tunnistuksessa

    OpenAIRE

    Alahäivälä, Aino-Lotta

    2015-01-01

    Raskauden tai synnytyksen aikana sikiön punasoluja voi kulkeutua istukan kautta äidin elimistöön. Jos sikiö on perinyt isältään äidille vieraita veriryhmä-antigeeneja, äidin elimistö tunnistaa ne ja saattaa aloittaa niitä vastaan vasta-ainetuotannon. Vuosittain noin 300-500 odottavalta äidiltä 65 000 äidistä todetaan sellainen veriryhmävasta-aine, joka voi aiheuttaa vastasyntyneen hemolyyttisen taudin. Yleisin raskaudenaikainen veriryhmäimmunisaatio on RhD-immunisaatio. RhD-immunisaatiossa Rh...

  7. Existence of Multiagent Equilibria with Limited Agents

    CERN Document Server

    Bowling, M; 10.1613/jair.1332

    2011-01-01

    Multiagent learning is a necessary yet challenging problem as multiagent systems become more prevalent and environments become more dynamic. Much of the groundbreaking work in this area draws on notable results from game theory, in particular, the concept of Nash equilibria. Learners that directly learn an equilibrium obviously rely on their existence. Learners that instead seek to play optimally with respect to the other players also depend upon equilibria since equilibria are fixed points for learning. From another perspective, agents with limitations are real and common. These may be undesired physical limitations as well as self-imposed rational limitations, such as abstraction and approximation techniques, used to make learning tractable. This article explores the interactions of these two important concepts: equilibria and limitations in learning. We introduce the question of whether equilibria continue to exist when agents have limitations. We look at the general effects limitations can have on agent b...

  8. The Translation of Numerals and its Limits

    Institute of Scientific and Technical Information of China (English)

    吴贤雯

    2013-01-01

    Through probing into the diversity of numerals’functions in language use which gives prominence to the importance of numeral translation, this paper aims to analyze the limits of numeral translation and explain the cause for these limits. The analy-sis of the limits in numeral translation is guided by the principle of functional equivalence. It is discussed that in numeral transla-tion, the limits on different levels of culture, image, sound and form arise when the full functional equivalence can not be achieved. Furthermore, this paper finds that the differences in culture and formal structure as well as the semantic fuzziness are three reasons for the presence of limits in numeral translation. However, the author suggests that these limits in numeral transla-tion can be adjusted with the further development of research on translation methodology and the deep infiltration of different cultures.

  9. Investigation of pulsed voltage limiters characteristics

    Directory of Open Access Journals (Sweden)

    Karimov A. V.

    2012-06-01

    Full Text Available A new method for measuring the voltage limit is offered. It has been designed to measure high-power pulsed current of voltage limiters. The error of this method is half as much as the error of the known method of direct measurement. The investigation of dependence of power capability of single-crystal and double-crystal voltage limiters and of the pulsed operation time on pulse duration.

  10. Nuclear Physics Around the Unitarity Limit

    CERN Document Server

    König, Sebastian; Hammer, H -W; van Kolck, U

    2016-01-01

    We argue that many features of the structure of nuclei can be understood in the unitarity limit, where the two-nucleon S-waves have bound states at zero energy. In this limit, the only dimensionful parameter, related to the breaking of scale invariance to a discrete scaling symmetry, is set by the triton binding energy. For A <= 4 nucleons, we demonstrate that the spectrum can be obtained as a controlled perturbative expansion around the unitarity limit.

  11. Limit Cycle Oscillations in Pacemaker Cells

    CERN Document Server

    Endresen, L P; Endresen, Lars Petter; Skarland, Nils

    1999-01-01

    In recent decades, several mathematical models describing the pacemaker activity of the rabbit sinoatrial node have been developed. We demonstrate that it is not possible to establish the existence, uniqueness, and stability of a limit cycle oscillation in those models. Instead we observe an infinite number of limit cycles. We then display numerical results from a new model, with a limit cycle that can be reached from many different initial conditions.

  12. The Limitations and Application Methods of Suggestopedia

    Institute of Scientific and Technical Information of China (English)

    李苗苗; 宋宝梅

    2015-01-01

    For a long time,college English teaching was mainly teacher-centered.Teachers played a dominant role in the classroom whereas students played a passive role.The"Suggestopedia"theory is such an effective way.However,there exist some limitations when apply the Suggestopedia theory.Teachers must pay attention to these limitations when apply the Suggestopedia theory.This thesis not only presents the limitations but also give some advises to the proper application of Suggestopedia Theory in teaching.

  13. The Limitations and Application Methods of Suggestopedia

    Institute of Scientific and Technical Information of China (English)

    李苗苗; 宋宝梅

    2015-01-01

    For a long time,college English teaching was mainly teacher-centered.Teachers played a dominant role in the classroom whereas students played a passive role.The"Suggestopedia" theory is such an effective way.However,there exist some limitations when apply the Suggestopedia theory.Teachers must pay attention to these limitations when apply the Suggestopedia theory.This thesis not only presents the limitations but also give some advises to the proper application of Suggestopedia Theory in teaching.

  14. Biological measurement beyond the quantum limit

    CERN Document Server

    Taylor, Michael A; Daria, Vincent; Knittel, Joachi; Hage, Boris; Bachor, Hans-A; Bowen, Warwick P

    2012-01-01

    Quantum noise places a fundamental limit on the per photon sensitivity attainable in optical measurements. This limit is of particular importance in biological measurements, where the optical power must be constrained to avoid damage to the specimen. By using non-classically correlated light, we demonstrated that the quantum limit can be surpassed in biological measurements. Quantum enhanced microrheology was performed within yeast cells by tracking naturally occurring lipid granules with sensitivity 2.4 dB beyond the quantum noise limit. The viscoelastic properties of the cytoplasm could thereby be determined with a 64% improved measurement rate. This demonstration paves the way to apply quantum resources broadly in a biological context.

  15. Inproved grade length limitation of freeways

    Institute of Scientific and Technical Information of China (English)

    XING En-hui; PEI Yu-long

    2006-01-01

    A method of ascertaining grade length limitation of freeways in mountain terrain is presented. The relationship models between 15th percentile speeds and grades were built through the surveys and analyses of operation speeds on 7 typical sections of 3 freeways in mountain terrain. Using 15th percentile and 85th percentile as speed limitations, the methods of determining admitted velocities were put forward according to the grades. Deceleration distances of longitudinal slopeways were analyzed utilizing the theories of vehicle. According to the results of analysis, grade length limitation was loosed. Finally the values of grade length limitation for freeways were put forward. The results could be used as references for freeway design.

  16. SHORT CIRCUIT CURRENT LIMITER IN AC NETWORK

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Short circuit is a serious fault in power network.Some novelcircuit topologies of current limiter using power electronic technology have been developed,which can limit the fault current to any desired level without much penalty.The operating principle and control strategies of such current limiters are discussed in detail.Simulation and experimental results are given to verify the performance of the current limiter,which can meet the requirements set for locations of bus tie,feeder,as well as the main transformer in the distribution network.

  17. Fundamental gravitational limitations to quantum computing

    CERN Document Server

    Gambini, R; Pullin, J; Gambini, Rodolfo; Porto, Rafael A.; Pullin, Jorge

    2005-01-01

    Lloyd has considered the ultimate limitations physics places on quantum computers. He concludes in particular that for an ``ultimate laptop'' (a computer of one liter of volume and one kilogram of mass) the maximum number of operations per second is bounded by $10^{51}$. The limit is derived considering ordinary quantum mechanics. Here we consider additional limits that are placed by quantum gravity ideas, namely the use of a relational notion of time and fundamental gravitational limits that exist on time measurements. We then particularize for the case of an ultimate laptop and show that the maximum number of operations is further constrained to $10^{47}$ per second.

  18. Impact limiter retention using a tape joint

    International Nuclear Information System (INIS)

    Sandia National Laboratories has developed the Beneficial Uses Shipping System (BUSS) cask for the transportation of up to a megacurie of radiation source capsules. This work was done under contract to the Department of Energy. The BUSS cask employs polyurethane foam impact limiters that fit onto the ends of the cask. A foam impact limiter takes energy out of the system during a hypothetical accident condition by allowing foam crush and large deformations to occur. This, in turn, precludes high stresses or deformations from occurring in the cask. Depending on the nature of the impact limiters and large deformations experienced, retaining the limiters on a cask during a 9 meter regulatory drop poses a design challenge. Impact limiter retention becomes a concern to ensure the cask does not experience higher decelerations during secondary impacts without impact limiters in place. During the 9 meter drop, the impact limiters absorb the energy required to confine the cask deceleration to acceptable levels. However, if the impact limiters were removed from the cask due to initial impact, higher cask stress levels could occur during any secondary or rebound effects. A tape joint has been designed to solve the problem of retaining impact limiters onto the BUSS cask during impact loadings

  19. Fundamental Quantum Limit to Waveform Detection

    CERN Document Server

    Tsang, Mankei

    2012-01-01

    Ever since the inception of gravitational-wave detectors, limits imposed by quantum mechanics to the detection of time-varying signals have been a subject of intense research and debate. Drawing insights from quantum information theory, quantum detection theory, and quantum measurement theory, here I prove a general lower limit to the average error probability for waveform detection with a quantum system. In the case of optomechanical force detection, I derive analytic expressions for the limit in some cases of interest and discuss how the limit can be approached using quantum control techniques.

  20. Implementing Risk-Limiting Audits in California

    OpenAIRE

    Hall, Joseph L.; Miratrix, Luke W.; Stark, Philip B.; Briones, Melvin; Ginnold, Elaine; Oakley, Freddie; Peaden, Martin; Pellerin, Gail; Stanionis, Tom; Webber, Tricia

    2009-01-01

    Risk-limiting post-election audits limit the chance of certifying an electoral outcome if the outcome is not what a full hand count would show. Building on previous work, we report on pilot risk-limiting audits in four elections during 2008 in three California counties: one during the February 2008 Primary Election in Marin County and three during the November 2008 General Elections in Marin, Santa Cruz and Yolo Counties. We explain what makes an audit risk-limiting and how existing and pro...

  1. 32 CFR 935.132 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Speed limits. 935.132 Section 935.132 National... WAKE ISLAND CODE Motor Vehicle Code § 935.132 Speed limits. Each person operating a motor vehicle on Wake Island shall operate it at a speed— (a) That is reasonable, safe, and proper, considering time...

  2. 33 CFR 401.28 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Speed limits. 401.28 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.28 Speed limits. (a) The maximum speed over the bottom for a vessel of more than 12 m in overall length shall be regulated so as not...

  3. Tokamak advanced pump limiter experiments and analysis

    International Nuclear Information System (INIS)

    Experiments with pump limiter modules on several operating tokamaks establish such limiters as efficient collectors of particles and has demonstrated the importance of ballistic scattering as predicted theoretically. Plasma interaction with recycling neutral gas appears to become important as the plasma density increases and the effective ionization mean free path within the module decreases. In limiters with particle collection but without active internal pumping, the neutral gas pressure is found to vary nonlinearly with the edge plasma density at the highest densities studies. Both experiments and theory indicate that the energy spectrum of gas atoms in the pump ducting is non-thermal, consistent with the results of Monte Carlo neutral atom transport calculations. The distribution of plasma power over the front surface of such modules has been measured and appears to be consistent with the predictions of simple theory. Initial results from the latest experiment on the ISX-B tokamak with an actively pumped limiter module demonstrates that the core plasma density can be controlled with a pump limiter and that the scrape-off layer plasma can partially screen the core plasma from gas injection. The results from module pump limiter experiments and from the theory and design analysis of advanced pump limiters for reactors are used to suggest the major features of a definitive, axisymmetric, toroidal belt pump limiter experiment

  4. 14 CFR 142.31 - Advertising limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Advertising limitations. 142.31 Section 142...) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.31 Advertising limitations. (a) A certificate holder may not conduct, and may not advertise to conduct, any training, testing, and checking...

  5. 14 CFR 141.23 - Advertising limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Advertising limitations. 141.23 Section 141...) SCHOOLS AND OTHER CERTIFICATED AGENCIES PILOT SCHOOLS General § 141.23 Advertising limitations. (a) The... certificate may not advertise that the school is certificated unless it clearly differentiates between...

  6. Optical limiting in semiconductor-doped glasses

    Science.gov (United States)

    Bindra, K. S.; Oak, S. M.; Rustagi, K. C.

    1996-02-01

    We report optical limiting at 527 nm in two Schott semiconductor-doped glasses OG530 and OG515. These two glasses show quite contrasting nonlinear optical behaviour. The glass OG515 shows strong clamping while OG530 shows no clamping in optical limiting inspite of having much larger nonlinear refractive index. Similarly OG530 exhibits saturation of absorption while OG515 does not.

  7. 14 CFR 43.16 - Airworthiness limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Airworthiness limitations. 43.16 Section 43.16 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT MAINTENANCE, PREVENTIVE MAINTENANCE, REBUILDING, AND ALTERATION § 43.16 Airworthiness limitations. Each...

  8. Visualizing the Central Limit Theorem through Simulation

    Science.gov (United States)

    Ruggieri, Eric

    2016-01-01

    The Central Limit Theorem is one of the most important concepts taught in an introductory statistics course, however, it may be the least understood by students. Sure, students can plug numbers into a formula and solve problems, but conceptually, do they really understand what the Central Limit Theorem is saying? This paper describes a simulation…

  9. 26 CFR 1.856-2 - Limitations.

    Science.gov (United States)

    2010-04-01

    ... gain from the sale or other disposition of real property for the 30-percent-of-gross-income limitation... or taxes, does not constitute the acquisition of “other property” for purposes of this subparagraph... TAXES Real Estate Investment Trusts § 1.856-2 Limitations. (a) Effective date. The provisions of part...

  10. 47 CFR 24.133 - Emission limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Emission limits. 24.133 Section 24.133... SERVICES Narrowband PCS § 24.133 Emission limits. (a) The power of any emission shall be attenuated below... the lesser attenuation. (b) The measurements of emission power can be expressed in peak or...

  11. 47 CFR 90.1323 - Emission limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission limits. 90.1323 Section 90.1323... MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1323 Emission limits. (a) The power of any emission outside a licensee's frequency band(s) of operation shall be...

  12. 40 CFR 63.802 - Emission limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Emission limits. 63.802 Section 63.802... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS FOR SOURCE CATEGORIES (CONTINUED) National Emission Standards for Wood Furniture Manufacturing Operations § 63.802 Emission limits. (a) Each owner or...

  13. 40 CFR 61.162 - Emission limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Emission limits. 61.162 Section 61.162... EMISSION STANDARDS FOR HAZARDOUS AIR POLLUTANTS National Emission Standard for Inorganic Arsenic Emissions From Glass Manufacturing Plants § 61.162 Emission limits. (a) The owner or operator of an...

  14. 47 CFR 90.669 - Emission limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission limits. 90.669 Section 90.669... 896-901/935-940 Mhz Band § 90.669 Emission limits. (a) On any frequency in an MTA licensee's spectrum block that is adjacent to a non-MTA frequency, the power of any emission shall be attenuated below...

  15. 5 CFR 185.147 - Limitations.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Limitations. 185.147 Section 185.147 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.147 Limitations. (a) The notice of hearing with respect to a claim or statement must be served...

  16. Bargaining with Many Players: A Limit Result

    OpenAIRE

    Klaus Kultti; Hannu Vartiainen

    2008-01-01

    We provide a simple characterization of the stationary subgame perfect equilibrium of an alternating offers bargaining game when the number of players increases without a limit. Core convergence literature is emulated by increasing the number of players by replication. The limit allocation is interpreted in terms of Walrasian market for being the first proposer.

  17. Back to Classics: Teaching Limits through Infinitesimals.

    Science.gov (United States)

    Todorov, Todor D.

    2001-01-01

    Criticizes the method of using calculators for the purpose of selecting candidates for L, for the limit value of a function. Suggests an alternative: a working formula for calculating the limit value L of a real function in terms of infinitesimals. (Author/ASK)

  18. Central Limit Theorem for Coloured Hard Dimers

    Directory of Open Access Journals (Sweden)

    Maria Simonetta Bernabei

    2010-01-01

    Full Text Available We study the central limit theorem for a class of coloured graphs. This means that we investigate the limit behavior of certain random variables whose values are combinatorial parameters associated to these graphs. The techniques used at arriving this result comprise combinatorics, generating functions, and conditional expectations.

  19. 46 CFR 45.185 - Tow limitations.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Tow limitations. 45.185 Section 45.185 Shipping COAST... Barges on Lake Michigan Routes § 45.185 Tow limitations. (a) Barges must not be manned. (b) No more than three barges per tow on the Milwaukee, St. Joseph, and Muskegon routes. (c) Barges must not be more...

  20. 47 CFR 15.315 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unlicensed Personal Communications Service Devices § 15.315 Conducted limits. An unlicensed PCS device that is designed to be connected to the public utility (AC) power line must meet the limits specified in § 15.207....

  1. Common Cause Abduction : Its Scope and Limits

    NARCIS (Netherlands)

    Dziurosz-Serafinowicz, Patryk

    2012-01-01

    Patryk Dziurosz-Serafmowicz, Common Cause Abduction: Its Scope and Limits This article aims to analyze the scope and limits of common cause abduction which is a version of explanatory abduction based on Hans Reichenbach's Principle of the Common Cause. First, it is argued that common cause abduction

  2. 50 CFR 20.33 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Possession limit. 20.33 Section 20.33...) TAKING, POSSESSION, TRANSPORTATION, SALE, PURCHASE, BARTER, EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) MIGRATORY BIRD HUNTING Possession § 20.33 Possession limit. No person shall...

  3. 47 CFR 95.1019 - Marketing limitations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Marketing limitations. 95.1019 Section 95.1019 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Low Power Radio Service (LPRS) General Provisions § 95.1019 Marketing limitations....

  4. 47 CFR 95.1219 - Marketing limitations.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Medical Device Radiocommunication Service (MedRadio) § 95.1219 Marketing limitations. Transmitters intended for operation in the MedRadio Service may be marketed and sold only for the permissible... 47 Telecommunication 5 2010-10-01 2010-10-01 false Marketing limitations. 95.1219 Section...

  5. Performance Limitation of Subband Adaptive Equalisers

    OpenAIRE

    Mohamod, H.; Weiss, S.; Rupp, M.; Hanzo, L.

    2006-01-01

    The aim of this reported work was identifying and quantifying limitation for the subband adaptive equalisers. The derived Wiener solution is compared against simulations for the subband equaliser, and it is verified that aliasing caused in the subband decimation can be considered equivalent to channel noise. Finally, how this limitation can be mitigated by careful system design is discussed.

  6. 45 CFR 5.35 - Time limits.

    Science.gov (United States)

    2010-10-01

    ... call or write to confirm that we have the request and to learn its status if you have not heard from us... circumstances” include situations when we: (1) Search for and collect records from field facilites, archives, or... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide...

  7. Back to Classics: Teaching Limits Through Infinitesimals

    CERN Document Server

    Todorov, Todor D

    2011-01-01

    The usual $\\epsilon,\\delta$-definition of the limit of a function (whether presented at a rigorous or an intuitive level) requires a "candidate $L$" for the limit value. Thus, we have to start our first calculus course with "guessing" instead of "calculating". In this paper we criticize the method of using calculators for the purpose of selecting candidates for $L$. We suggest an alternative: a working formula for calculating the limit value L of a real function in terms of infinitesimals. Our formula, if considered as a definition of limit, is equivalent to the usual $\\epsilon,\\delta$-definition but does not involve a candidate $L$ for the limit value. As a result, the Calculus becomes to "calculate" again as it was originally designed to do.

  8. Reverse engineering of inductive fault current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Pina, J M; Neves, M Ventim; Rodrigues, A L [Centre of Technology and Systems Faculdade de Ciencias e Tecnologia, Nova University of Lisbon Monte de Caparica, 2829-516 Caparica (Portugal); Suarez, P; Alvarez, A, E-mail: jmmp@fct.unl.p [' Benito Mahedero' Group of Electrical Applications of Superconductors Escuela de IngenierIas Industrials, University of Extremadura Avenida de Elvas s/n, 06006 Badajoz (Spain)

    2010-06-01

    The inductive fault current limiter is less compact and harder to scale to high voltage networks than the resistive one. Nevertheless, its simple construction and mechanical robustness make it attractive in low voltage grids. Thus, it might be an enabling technology for the advent of microgrids, low voltage networks with dispersed generation, controllable loads and energy storage. A new methodology for reverse engineering of inductive fault current limiters based on the independent analysis of iron cores and HTS cylinders is presented in this paper. Their electromagnetic characteristics are used to predict the devices' hysteresis loops and consequently their dynamic behavior. Previous models based on the separate analysis of the limiters' components were already derived, e.g. in transformer like equivalent models. Nevertheless, the assumptions usually made may limit these models' application, as shown in the paper. The proposed methodology obviates these limitations. Results are validated through simulations.

  9. Pumped limiter results on TFR Tokamak plasma

    International Nuclear Information System (INIS)

    Pump limiter experiments are carried out in the TFR Tokamak. The pump limiter is located in the outer part of the torus, its double- throat head is made of graphite tiles and it is pumped by a 2000 ls-1 titanium sublimation pump. The first attempts showed that the exhaust efficiency of this pump limiter was low (ε = 1.5% of the total plasma particle efflux). To improve these results, a new limiter head with a single longer throat has been built; particles were better trapped and the pumping provided an important decrease of the recycling coefficient. Geometric features mainly explain the increase by a factor 3.5 of the exhaust efficiency (ε = 5.5%). Ion temperature of the order of a few eV has been deduced from Doppler broadening measurements at the neutralizer plate of the pump limiter

  10. Well limit behaviors of term rewriting systems

    Institute of Scientific and Technical Information of China (English)

    MA Shilong; SUI Yuefei; XU Ke

    2007-01-01

    The limit behaviors of computations have not been fully explored.It is necessary to consider such limit behaviors when we consider the properties of infinite objects in computer science,such as infinite logic programs,the symbolic solutions of infinite polynomial equations.Usually,we can use finite objects to approximate infinite objects,and we should know what kinds of infinite objects are approximable and how to approximate them effectively.A sequence {Rκ:κω}of term rewriting systems has the well limit behavior if under the condition that the sequence has the Set-theoretic limit or the distance-based limit,the sequence {Th(Rκ):κ∈ω} of corresponding theoretic closures of Rκ has the set-theoretic or distance-based limit,and limκ→∞ Th(Rκ) is equal to the theoretic closure of the limit of {Rκ:κ∈ω).Two kinds of limits of term rewriting systems are considered:one is based on the set-theoretic limit,the other is on the distance-based limit.It is proved thatgiven a sequence {Rκ:κ∈ω) of term rewriting systems Rκ,if there is a well-founded ordering (-<) on terms such that every Rκ is (-<)-well-founded,and the set-theoretic limit of {Rκ:κ∈ω).exists,then {Rκ:κ∈ω).has the well limit behavior;and if (1) there is a well-founded ordering(-<)on terms such that every Rκ is(-<-well-founded,(2) there is a distance d on terms which is closed under substitutions and contexts and (3) {Rκ:κ∈ω).is Cauchy under d then {Rκ:κ∈ω).has the well limit behavior.The results are used to approximate the least Herbrand models of infinite Horn logic programs and real Horn logic programs,and the solutions and Cr(o)bner bases of (infinite) sets of real polynomials by sequences of (finite) sets of rational polynomials.

  11. The limits on trypanosomatid morphological diversity.

    Directory of Open Access Journals (Sweden)

    Richard John Wheeler

    Full Text Available Cell shape is one, often overlooked, way in which protozoan parasites have adapted to a variety of host and vector environments and directional transmissions between these environments. Consequently, different parasite life cycle stages have characteristic morphologies. Trypanosomatid parasites are an excellent example of this in which large morphological variations between species and life cycle stage occur, despite sharing well-conserved cytoskeletal and membranous structures. Here, using previously published reports in the literature of the morphology of 248 isolates of trypanosomatid species from different hosts, we perform a meta-analysis of the occurrence and limits on morphological diversity of different classes of trypanosomatid morphology (trypomastigote, promastigote, etc. in the vertebrate bloodstream and invertebrate gut environments. We identified several limits on cell body length, cell body width and flagellum length diversity which can be interpreted as biomechanical limits on the capacity of the cell to attain particular dimensions. These limits differed for morphologies with and without a laterally attached flagellum which we suggest represent two morphological superclasses, the 'juxtaform' and 'liberform' superclasses. Further limits were identified consistent with a selective pressure from the mechanical properties of the vertebrate bloodstream environment; trypanosomatid size showed limits relative to host erythrocyte dimensions. This is the first comprehensive analysis of the limits of morphological diversity in any protozoan parasite, revealing the morphogenetic constraints and extrinsic selection pressures associated with the full diversity of trypanosomatid morphology.

  12. Density Limits in Toroidal Magnetic Confinement Experiments

    Science.gov (United States)

    Greenwald, Martin

    2001-10-01

    The density limit represents one of the fundamental operating boundaries for magnetic confinement devices - one with practical importance to the goal of fusion power. With fusion reactivity maximized at a plasma temperature on the order of 10 keV and a reaction rate scaling as n^2, an optimum density can be calculated which is not guaranteed to be achievable in any given device. Unlike operational limits for plasma current or pressure, the density limit cannot be explained by magneto-hydrodynamics alone. There is general agreement that the proximate cause for the disruptive limit in the tokamak is cooling of the plasma edge and subsequent current profile shrinkage. The edge cooling may be dominated by atomic physics processes or as suggested in recent experiments, by anomalous transport. A similar picture is emerging for the reversed field pinch (RFP), while the limit in stellarators is apparently due to loss of thermal equilibrium from radiation. Empirical scaling laws in which the maximum plasma density is proportional to the average current density have been fairly successful in predicting the limit for subsequent experiments. Surprisingly, the density limits found in tokamaks and RFPs are virtually identical. Currentless stellarators reach similar density limits, though the expression needs to be recast in terms of the rotational transform. While scaling laws have done a reasonable job in describing data from many recent experiments, they can only give hints at the underlying physics. Understanding the mechanism for the density limit is crucial for extrapolating machine performance into untested regimes and so far, a completely satisfactory theory has not emerged. It seems likely that robust, reliable predictions will only come from the development of a first-principles theory backed up by detailed experimental observations. The extensive work already accomplished and reviewed here should provide a solid basis for such development.

  13. Limit theorems for 2D invasion percolation

    CERN Document Server

    Damron, Michael

    2010-01-01

    We prove limit theorems and variance estimates for quantities related to ponds and outlets for 2D invasion percolation. We first exhibit several properties of a sequence (O(n)) of outlet variables, the n-th of which gives the number of outlets in the box centered at the origin of side length 2^n. The most important of these properties describe the sequence's renewal structure and exponentially fast mixing behavior. We use these to prove a central limit theorem and strong law of large numbers for (O(n)). We then show consequences of these limit theorems for the pond radii and outlet weights.

  14. Extreme Physics and Informational/Computational Limits

    Energy Technology Data Exchange (ETDEWEB)

    Di Sia, Paolo, E-mail: paolo.disia@univr.it, E-mail: 10alla33@virgilio.it [Department of Computer Science, Faculty of Science, Verona University, Strada Le Grazie 15, I-37134 Verona (Italy) and Faculty of Computer Science, Free University of Bozen, Piazza Domenicani 3, I-39100 Bozen-Bolzano (Italy)

    2011-07-08

    A sector of the current theoretical physics, even called 'extreme physics', deals with topics concerning superstring theories, multiverse, quantum teleportation, negative energy, and more, that only few years ago were considered scientific imaginations or purely speculative physics. Present experimental lines of evidence and implications of cosmological observations seem on the contrary support such theories. These new physical developments lead to informational limits, as the quantity of information, that a physical system can record, and computational limits, resulting from considerations regarding black holes and space-time fluctuations. In this paper I consider important limits for information and computation resulting in particular from string theories and its foundations.

  15. Optimal Disturbance Accommodation with Limited Model Information

    CERN Document Server

    Farokhi, F; Johansson, K H

    2011-01-01

    The design of optimal dynamic disturbance-accommodation controller with limited model information is considered. We adapt the family of limited model information control design strategies, defined earlier by the authors, to handle dynamic-controllers. This family of limited model information design strategies construct subcontrollers distributively by accessing only local plant model information. The closed-loop performance of the dynamic-controllers that they can produce are studied using a performance metric called the competitive ratio which is the worst case ratio of the cost a control design strategy to the cost of the optimal control design with full model information.

  16. Inviscid incompressible limits on expanding domains

    OpenAIRE

    Feireisl, E.; Nečasová, Š. (Šárka); Y. Sun

    2014-01-01

    We consider the inviscid incompressible limit of the compressible Navier-Stokes system on a large domain, the radius of which becomes infinite in the asymptotic limit. We show that the limit solutions satisfy the incompressible Euler system on the whole physical space R3 as long as the radius of the domain is larger than the speed of acoustic waves inversely proportional to the Mach number. The rate of convergence is estimated in terms of the Mach and Reynolds numbers and the radius of the fa...

  17. Cosmological Background torsion limits from Lorentz violation

    CERN Document Server

    Garcia de Andrade, L C

    2001-01-01

    Cosmological limits on Lorentz invariance breaking in Chern-Simons $(3+1)-dimensional$ electrodynamics are used to place limits on torsion. Birefrigence phenomena is discussed by using extending the propagation equation to Riemann-Cartan spacetimes instead of treating it in purely Riemannian spaces. The parameter of Lorentz violation is shown to be proportional to the axial torsion vector which allows us to place a limit on cosmological background torsion from the Lorentz violation constraint which is given by $ 10^{-33} eV <|S^{\\mu}| < 10^{-32} eV$ where $|S^{\\mu}|$ is the axial torsion vector.

  18. Fractional Diffusion Limit for Collisional Kinetic Equations

    KAUST Repository

    Mellet, Antoine

    2010-08-20

    This paper is devoted to diffusion limits of linear Boltzmann equations. When the equilibrium distribution function is a Maxwellian distribution, it is well known that for an appropriate time scale, the small mean free path limit gives rise to a diffusion equation. In this paper, we consider situations in which the equilibrium distribution function is a heavy-tailed distribution with infinite variance. We then show that for an appropriate time scale, the small mean free path limit gives rise to a fractional diffusion equation. © 2010 Springer-Verlag.

  19. The limits for life under multiple extremes.

    Science.gov (United States)

    Harrison, Jesse P; Gheeraert, Nicolas; Tsigelnitskiy, Dmitry; Cockell, Charles S

    2013-04-01

    Life on Earth is limited by physical and chemical extremes that define the 'habitable space' within which it operates. Aside from its requirement for liquid water, no definite limits have been established for life under any extreme. Here, we employ growth data published for 67 prokaryotic strains to explore the limitations for microbial life under combined extremes of temperature, pH, salt (NaCl) concentrations, and pressure. Our review reveals a fundamental lack of information on the tolerance of microorganisms to multiple extremes that impedes several areas of science, ranging from environmental and industrial microbiology to the search for extraterrestrial life. PMID:23453124

  20. Limitations of science and adaptive management

    Energy Technology Data Exchange (ETDEWEB)

    Narasimhan, T.N.

    2001-12-20

    Adaptive management consists in patterning human sustenancewithin the constraints of Earth and biological systems whose behavior isinherently uncertain and difficult to control. For successful adaptivemanagement, a mind-set recognizing the limitations of science isneeded.

  1. Limiting Spectral Distribution of Sample Autocovariance Matrices

    CERN Document Server

    Basak, Anirban; Sen, Sanchayan

    2011-01-01

    The empirical spectral distribution (ESD) of the sample variance covariance matrix of i.i.d. observations under suitable moment conditions converges almost surely as the dimension tends to infinity. The limiting spectral distribution (LSD) is universal and is known in closed form with support [0, 4]. In this article we show that the ESD of the sample autocovariance matrix converges as the dimension increases, when the time series is a linear process with reasonable restriction on the coefficients. This limit does not depend on the distribution of the underlying driving i.i.d. sequence but in contrast to the sample variance covariance matrix, its support is unbounded. The limit moments are certain functions of the autocovariances. This limit is inconsistent in the sense that it does not coincide with the spectral distribution of the theoretical autocovariance matrix. However, if we consider a suitably tapered version of the autocovariance matrix, then its LSD also exists and is consistent. We also discuss the ...

  2. The computation of Buehler confidence limits

    Institute of Scientific and Technical Information of China (English)

    FANG; Xiangzhong; CHEN; Jiading

    2005-01-01

    In medicine and industry, small sample size often arises owing to the high test cost. Then exact confidence inference is important. Buehler confidence limit is a kind of exact confidence limit for the function of parameters in a model. It can be always defined if the order in sample space is given. But the computing problem is often difficult, especially for the cases with high dimension parameter or with incomplete data. This paper presents an algorithm to compute the Buehler confidence limits by EM algorithm. This is the firsttime usage of EM algorithm on Buehler confidence limits, but the algorithm is often used for maximum likelihood estimate in literatures. Three computation examples are given to illustrate the method.

  3. Scallop License Limitation Program (SLLP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

  4. 48 CFR 16.301-3 - Limitations.

    Science.gov (United States)

    2010-10-01

    ... cost-reimbursement contracts is prohibited for the acquisition of commercial items (see parts 2 and 12). ... AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 16.301-3 Limitations. (a) A...

  5. Cities, Towns and Villages - City Limit (polygon)

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — Data available online through GeoStor at http://www.geostor.arkansas.gov. Arkansas Cities: This data set contains all of the city limit boundaries within the state...

  6. Limitations of science and adaptive management

    OpenAIRE

    Narasimhan, T. N.

    2001-01-01

    Adaptive management consists in patterning human sustenance within the constraints of Earth and biological systems whose behavior is inherently uncertain and difficult to control. For successful adaptive management, a mind-set recognizing the limitations of science is needed.

  7. Some Limit Theorems in Geometric Processes

    Institute of Scientific and Technical Information of China (English)

    Yeh Lam; Yao-hui Zheng; Yuan-lin Zhang

    2003-01-01

    Geometric process (GP) was introduced by Lam[4,5], it is defined as a stochastic process {Xn, n =1, 2,...} for which there exists a real number a > 0, such that {an-1Xn, n = 1, 2,...} forms a renewal process (RP). In this paper, we study some limit theorems in GP. We first derive the Wald equation for GP and then obtain the limit theorems of the age, residual life and the total life at t for a GP. A general limit theorem for Sn with a > 1 is also studied. Furthermore, we make a comparison between GP and RP, including the comparison of their limit distributions of the age, residual life and the total life at t.

  8. Health Outcomes Survey - Limited Data Set

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Medicare Health Outcomes Survey (HOS) limited data sets (LDS) are comprised of the entire national sample for a given 2-year cohort (including both respondents...

  9. Does decoherence in the thermodynamic limit exist?

    CERN Document Server

    Frasca, M

    2002-01-01

    We consider the Jaynes-Cummings model for N particles in the thermodynamic limit showing how it can produce decoherence on a Schr\\"odinger cat state. This mechanism can be observed in current experiments with cavities.

  10. Sensitivity Limitations for Multivariable Linear Filtering

    Directory of Open Access Journals (Sweden)

    Steven R. Weller

    2007-01-01

    Full Text Available This paper examines fundamental limitations in performance which apply to linear filtering problems associated with multivariable systems having as many inputs as outputs. The results of this paper quantify unavoidable limitations in the sensitivity of state estimates to process and measurement disturbances, as represented by the maximum singular values of the relevant transfer matrices. These limitations result from interpolation constraints imposed by open right half-plane poles and zeros in the transfer matrices linking process noise and output noise with state estimates. Using the Poisson integral inequality, this paper shows how sensitivity limitations and tradeoffs in multivariable filtering problems are intimately related to the directionality properties of the open right half-plane poles and zeros in these transfer matrices.

  11. Recognizing limitations in eddy current testing

    International Nuclear Information System (INIS)

    This paper addresses known limitations and constraints in eddy current nondestructive testing. Incomplete appreciation for eddy current limitations is believed to have contributed to both under-utilization and misapplication of the technique. Neither situation need arise if known limitations are recognized. Some, such as the skin depth effect, are inherent to electromagnetic test methods and define the role of eddy current testing. Others can be overcome with available technology such as surface probes to find circumferential cracks in tubes and magnetic saturation of ferromagnetic alloys to eliminate permeability effects. The variables responsible for limitations in eddy current testing are discussed and where alternative approaches exist, these are presented. Areas with potential for further research and development are also identified

  12. Southern Hemisphere Ice Limits, 1973-1978

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Weekly Southern Ocean ice limits, have been digitized from U.S. Navy Fleet Weather Facility ice charts, at the Max-Planck Institut fur Meteorologie, Hamburg....

  13. 26 CFR 1.851-2 - Limitations.

    Science.gov (United States)

    2010-04-01

    ... TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.851-2 Limitations. (a... manufacturing or of any other general classification of industry, but issuers shall be construed to be...

  14. Optical limiting by chemically enhanced bacteriorhodopsin films

    Science.gov (United States)

    Song, Q. Wang; Zhang, Chungping; Gross, Richard; Birge, Robert

    1993-05-01

    Measurements of effective nonlinearity of a chemically enhanced bacteriorhodopsin film are presented, using 2-scan method. Optical limiting properties and the film's nonlinear transmission properties of the film are also studied.

  15. Limit Interchange and L'Hopital's Rule

    Science.gov (United States)

    Ecker, Michael W.

    2011-01-01

    Conventional application of these two calculus staples is stretched here, somewhat recreationally, but also to raise solid questions about the role of limit interchange in analysis--without, however, delving any deeper than first-year Calculus.

  16. Stable convergence and stable limit theorems

    CERN Document Server

    Häusler, Erich

    2015-01-01

    The authors present a concise but complete exposition of the mathematical theory of stable convergence and give various applications in different areas of probability theory and mathematical statistics to illustrate the usefulness of this concept. Stable convergence holds in many limit theorems of probability theory and statistics – such as the classical central limit theorem – which are usually formulated in terms of convergence in distribution. Originated by Alfred Rényi, the notion of stable convergence is stronger than the classical weak convergence of probability measures. A variety of methods is described which can be used to establish this stronger stable convergence in many limit theorems which were originally formulated only in terms of weak convergence. Naturally, these stronger limit theorems have new and stronger consequences which should not be missed by neglecting the notion of stable convergence. The presentation will be accessible to researchers and advanced students at the master's level...

  17. Limit calculation in MSSM Higgs boson searches

    Energy Technology Data Exchange (ETDEWEB)

    Berger, Joram; Caspart, Rene; Colombo, Fabio; Boer, Wim de; Frensch, Felix; Friese, Raphael; Gilbert, Andrew; Mueller, Thomas; Quast, Guenter; Treiber, Benjamin; Wolf, Roger [Institut fuer Experimentelle Kernphysik (IEKP), KIT (Germany)

    2015-07-01

    After run one of the LHC Supersymmetry still remains one of the favorite theories for physics beyond the Standard Model. In the minimal realization of Supersymmetry, the minimal supersymmetric Standard Model, five Higgs bosons exist. In my presentation I present limit calculation approaches for MSSM Higgs boson searches. The talk focuses on model dependent limit calculation by combining different charged and neutral MSSM Higgs boson searches.

  18. Gulf of Mexico mud toxicity limitations

    Energy Technology Data Exchange (ETDEWEB)

    Dunn, H.E.; Beardmore, D.H. (Phillips Petroleum Co., Bartlesville, OK (USA)); Stewart, W.S. (Drilling Specialties Co. (US))

    1989-10-01

    Because of the Environmental Protection Agency's recent toxicity limits on drilling mud discharges for offshore Gulf of Mexico, Phillips Petroleum conducted a mud toxicity study based on both field and lab tests. The study, discussed in this article, found the polyanionic cellulose-sulfomethylated quebracho-chrome lignosulfonate mud Phillips had been using would comfortably pass the toxicity limitations. The study also found barite and thinners were of low toxicity, and hydrocarbons and surfactants were highly toxic.

  19. Semiclassical limit of the FZZT Liouville theory

    CERN Document Server

    Hadasz, L; Hadasz, Leszek; Jaskolski, Zbigniew

    2006-01-01

    The semiclassical limit of the FZZT Liouville theory on the upper half plane with bulk operators of arbitrary type and with elliptic boundary operators is analyzed. We prove the Polyakov conjecture for an appropriate classical Liouville action. This action is calculated in a number of cases: one bulk operator of arbitrary type, one bulk and one boundary, and two boundary elliptic operators. The results are in agreement with the classical limits of the corresponding quantum correlators.

  20. Semiclassical limit of the FZZT Liouville theory

    Energy Technology Data Exchange (ETDEWEB)

    Hadasz, Leszek [Physikalisches Institut, Rheinische Friedrich-Wilhelms-Universitaet, Nussallee 12, 53115 Bonn (Germany); M. Smoluchowski Institute of Physics, Jagiellonian University, W. Reymonta 4, 30-059 Cracow (Poland)]. E-mail: hadasz@th.if.uj.edu.pl; Jaskolski, Zbigniew [Institute of Theoretical Physics, University of Wroclaw, pl. M. Borna 9, 50-204 Wroclaw (Poland)]. E-mail: jask@ift.uni.wroc.pl

    2006-11-27

    The semiclassical limit of the FZZT Liouville theory on the upper half plane with bulk operators of arbitrary type and with elliptic boundary operators is analyzed. We prove the Polyakov conjecture for an appropriate classical Liouville action. This action is calculated in a number of cases: One bulk operator of arbitrary type, one bulk and one boundary, and two boundary elliptic operators. The results are in agreement with the classical limits of the corresponding quantum correlators.

  1. Compression limits in cascaded quadratic soliton compression

    DEFF Research Database (Denmark)

    Bache, Morten; Bang, Ole; Krolikowski, Wieslaw;

    2008-01-01

    Cascaded quadratic soliton compressors generate under optimal conditions few-cycle pulses. Using theory and numerical simulations in a nonlinear crystal suitable for high-energy pulse compression, we address the limits to the compression quality and efficiency.......Cascaded quadratic soliton compressors generate under optimal conditions few-cycle pulses. Using theory and numerical simulations in a nonlinear crystal suitable for high-energy pulse compression, we address the limits to the compression quality and efficiency....

  2. Very Massive Stars and the Eddington Limit

    CERN Document Server

    Crowther, Paul A; Walborn, Nolan R; Yusof, N

    2012-01-01

    We use contemporary evolutionary models for Very Massive Stars (VMS) to assess whether the Eddington limit constrains the upper stellar mass limit. We also consider the interplay between mass and age for the wind properties and spectral morphology of VMS, with reference to the recently modified classification scheme for O2-3.5If*/WN stars. Finally, the death of VMS in the local universe is considered in the context of pair instability supernovae.

  3. The Separate Universe Approach to Soft Limits

    CERN Document Server

    Kenton, Zachary

    2016-01-01

    We develop a formalism for calculating soft limits of $n$-point inflationary correlation functions using separate universe techniques. Our method naturally allows for multiple fields and leads to an elegant diagrammatic approach. As an application we focus on the trispectrum produced by inflation with multiple light fields, giving explicit formulae for all possible single- and double-soft limits. We also investigate consistency relations and present an infinite tower of inequalities between soft correlation functions which generalise the Suyama-Yamaguchi inequality.

  4. Revisiting Uraltsev's BPS limit for Heavy Quarks

    CERN Document Server

    Heinonen, Johannes

    2016-01-01

    Motivated by the recent experimental data of the values of the Heavy Quark Expansion parameters, in particular the spin-orbit and Darwin terms, we argue that nature actually may be close to a limit of QCD which has been suggested by Uraltsev more than ten years ago. Assuming that this limit is not accidental, we derive the relations among the Heavy Quark Expansion parameters that occur up to the order 1/mb^5.

  5. The Fragility of Limit Order Markets

    OpenAIRE

    Alasdair Brown

    2013-01-01

    Limit order markets - where a subset of traders provide liquidity on a discretionary basis - are the dominant exchange mechanism for financial assets. We analyse the resilience of these markets using Betfair limit order book trading on the Wimbledon Tennis Championships. As matches go inplay, the risk involved in liquidity provision intensifies, as the value of bets can change substantially in a matter of seconds, and, at the end of the match, certain bets are worthless. Our headline result i...

  6. Limits and Signatures of Relativistic Spaceflight

    CERN Document Server

    Yurtsever, Ulvi

    2015-01-01

    While special relativity imposes an absolute speed limit at the speed of light, our Universe is not empty Minkowski spacetime. The constituents that fill the interstellar/intergalactic vacuum, including the cosmic microwave background photons, impose a lower speed limit on any object travelling at relativistic velocities. Scattering of cosmic microwave phtotons from an ultra-relativistic object may create radiation with a characteristic signature allowing the detection of such objects at large distances.

  7. 50 CFR 622.37 - Size limits.

    Science.gov (United States)

    2010-10-01

    ...), TL. (iii) Cubera, dog, gray, mahogany, and yellowtail snappers and schoolmaster—12 inches (30.5 cm), TL. (iv) Red snapper -16 inches (40.6 cm), TL, for a fish taken by a person subject to the bag limit... to the bag limit specified in § 622.39(b)(1)(ii)—22 inches (55.9 cm), TL. (iv) Red grouper—(A) For...

  8. MMSE Limitations of Subband Adaptive Equalisers

    OpenAIRE

    Mohamad, H.; Weiss, S.; Rupp, M.

    2002-01-01

    In this contribution, we investigate limitations of the minimum mean square error (MMSE) solution for subband adaptive equalisers due to aliasing and error in power complementarity. By deriving the Wiener solution for the subband equaliser and comparing it against simulations, we verify that aliasing caused in the subband decimation can be considered equivalent to channel noise. We discuss how these limitations can be mitigated by careful system design.

  9. Supply and demand law under limited information

    OpenAIRE

    Zhang, Yi-Cheng

    2005-01-01

    We present a model for the supply-demand law with quality and limited information capability. We postulate that imperfect information permeates in almost all economic transactions to varying degrees. Through a simple model we outline a research agenda that re-examines many standard issues in economics. Our analysis shows that whereas imperfect information can be improved, it leads to new uncertainties so that the perfect information limit can never be reached. As a corollary neoclassical perf...

  10. Activity limitation in joint hypermobility syndrome.

    OpenAIRE

    Schmidt, A.

    2008-01-01

    This review examines the role of fear and avoidance in chronic pain, focusing in particular on their role in activity limitation. It examines the existing fear-avoidance models, in particular Vlaeyen and Linton's (2000) model, it reviews the evidence for this model, and considers it in the context of models of fear and avoidance in other psychological disorders. Evidence is reviewed for other factors which contribute to activity limitation in chronic pain. In the context of this evidence, it ...

  11. LIMITING BEHAVIOR OF UNIFORM RECURSIVE TREES

    Institute of Scientific and Technical Information of China (English)

    Su Chun; Feng Qunqiang; Liu Jie

    2007-01-01

    The authors consider the limiting behavior of various branches in a uniform recursive tree with size growing to infinity. The limiting distribution of ζn,m, the number of branches with size m in a uniform recursive tree of order n, converges weakly to a Poisson distribution with parameter 1/m with convergence of all moments. The size of any large branch tends to infinity almost surely.

  12. Environmental radiation standards and risk limitation

    International Nuclear Information System (INIS)

    The Environmental Protection Agency and Nuclear Regulatory Commission have established environmental radiation standards for specific practices which correspond to limits on risk to the public that vary by several orders of magnitude and often are much less than radiation risks that are essentially unregulated, e.g., risks from radon in homes. This paper discusses a proposed framework for environmental radiation standards that would improve the correspondence with limitation of risk. This framework includes the use of limits on annual effective dose equivalent averaged over a lifetime, rather than limits on dose equivalent to whole body or any organ for each year of exposure, and consideration of exposures of younger age groups as well as adults; limits on annual effective dose equivalent averaged over a lifetime no lower than 0.25 mSv (25 mrem) per practice; maintenance of all exposures as low as reasonably achievable (ALARA); and establishment of a generally applicable de minimis dose for public exposures. Implications of the proposed regulatory framework for the current system of standards for limiting public exposures are discussed. 20 refs

  13. Cryogenic Dark Matter Search: limits and projections

    International Nuclear Information System (INIS)

    The results from the second run of the Cryogenic Dark Matter Search experiment in the Soudan Underground Laboratory yields new exclusion limits on the coherent WIMPnucleon scalar cross-sections for WIMP masses above 15 GeV/c2. Two towers, each consisting of six detectors, were operated in the mine for 74.5 live days, doubling the previous Ge exposure to 34 kg-d after cuts for recoil energies of 10-100 keV. When combined with the data from the first run at Soudan, the new upper limit is 1.6 x 10-43 cm2 for a 60 GeV WIMP using the standard dark-matter halo and nuclear physics WIMP model. This is a factor of 2.5 lower than our previous limit and a factor of 10 lower than any other experiment. Limits from the Si data (12 kg-d) are less stringent, but extend the excluded region for low mass WIMPs. CDMS also has sensitivity to spin-dependent limits

  14. The Cognitive Limits to Economic Cluster Formation

    Directory of Open Access Journals (Sweden)

    Michael C. Carrol

    2012-01-01

    Full Text Available There has been increasing interest in the social dimensions of economic clusters. The literature now includes select examples of social network analysis plus an extensive discussion of learning regions. Unfortunately, much of this work treats the network as the primary unit of analysis. It may be that network attributes such as density, centrality, and power are primarily dependent on human limitations and not instituted factors. In other words, a human’s limited ability to process information may be a better determinant of cluster success than economic or network theory. The purpose of this paper is to highlight human limits in cluster formation. To do this, we draw on recent developments in the cognitive psychology and communications literatures. We explain that many of the factors that lead to underperforming cluster policies are the result of a human’s inability to develop and sustain a large number of social interactions. Any cluster policy must be cognizant of such limitations and carefully address these limits in the formation of the initial strategy.

  15. Limiting factors in caribou population ecology

    Directory of Open Access Journals (Sweden)

    David R. Klein

    1991-10-01

    Full Text Available Caribou and wild reindeer populations fluctuate over time. On this fact there is general agreement. Factors responsible for population limitation and subsequent declines have been examined within the framework of animal population theory. There is, however, little agreement when factors limiting specific populations are generalized to Rangifer populations over broad geographic regions. Comparative examinations of wild Rangifer populations worldwide discloses that factors that have regulated those populations are highly variable between populations, apparently as a reflection of the differences in environmental variables unique to each population. Examples exist of populations where major regulating factors have been climatic extremes, predation, hunting mortality, food limitation, insects, parasites, disease, interspecific competition, and human developmental impacts or combinations of these factors. This diversity of limiting factors affecting caribou and wild reindeer populations is a reflection of the ecologial complexity of the species, a concept that has often been ignored in past efforts to reach management decisions by extrapolation from the limited localized knowledge available on the species.

  16. Thermal Nature of Concentration Limits of Combustion

    Science.gov (United States)

    Sabdenov, K. O.; Baitasov, T. M.

    2015-05-01

    An explanation is proposed for the concentration limits of slow combustion of gas mixtures due to the diffusional-thermal instability of a flame and the leading role of the thermal effect of mixture combustion. Basic to this explanation are the following experimental facts obtained for a wide class of mixtures: the concentration limits of slow combustion of a mixture and of its detonation are closely coinciding and depend strongly on the stoichiometric composition of mixture; there is an approximate symmetry relation between the upper and lower combustion limits. It is shown that the flame temperature of gas mixtures depends on their stoichiometric composition and that as their stoichiometric relation deviates from unity, the state of mixture combustion approaches the stability threshold beyond which a stationary flame cannot exist.

  17. Occupational Exposures and Chronic Airflow Limitation

    Directory of Open Access Journals (Sweden)

    Helen Dimich-Ward

    1996-01-01

    Full Text Available The recent literature was reviewed to evaluate whether chronic airflow limitation is associated with occupational exposures to dusts. Only those studies that controlled for the effects of smoking were included. There is compelling evidence that exposure to inorganic dusts, such as from coal and hardrock mining or asbestos, are associated with the development of chronic airflow limitation, independently of pneumoconiosis. Nonsmoking gold miners are particularly at high risk of airflow obstruction and emphysema. Findings from studies of organic dusts, such as exposures to wood, cotton, grain or other agricultural dusts, or to mixed dust exposures, were less consistent but tended to show positive dose-response associations. In the majority of studies, no statistical interaction was shown between dust exposures and smoking; however, the effects of the dust exposures were often more pronounced. An occupational history should be considered, in addition to a smoking history, as an integral part of an investigation of chronic airflow limitation in a patient.

  18. Limitation of computational resource as physical principle

    CERN Document Server

    Ozhigov, Y I

    2003-01-01

    Limitation of computational resources is considered as a universal principle that for simulation is as fundamental as physical laws are. It claims that all experimentally verifiable implications of physical laws can be simulated by the effective classical algorithms. It is demonstrated through a completely deterministic approach proposed for the simulation of biopolymers assembly. A state of molecule during its assembly is described in terms of the reduced density matrix permitting only limited tunneling. An assembly is treated as a sequence of elementary scatterings of simple molecules from the environment on the point of assembly. A decoherence is treated as a forced measurement of quantum state resulted from the shortage of computational resource. All results of measurements are determined by a choice from the limited number of special options of the nonphysical nature which stay unchanged till the completion of assembly; we do not use the random numbers generators. Observations of equal states during the ...

  19. Multiple Soft Limits of Cosmological Correlation Functions

    CERN Document Server

    Joyce, Austin; Simonović, Marko

    2015-01-01

    We derive novel identities satisfied by inflationary correlation functions in the limit where two external momenta are taken to be small. We derive these statements in two ways: using background-wave arguments and as Ward identities following from the fixed-time path integral. Interestingly, these identities allow us to constrain some of the O(q^2) components of the soft limit, in contrast to their single-soft analogues. We provide several nontrivial checks of our identities both in the context of resonant non-Gaussianities and in small sound speed models. Additionally, we extend the relation at lowest order in external momenta to arbitrarily many soft legs, and comment on the many-soft extension at higher orders in the soft momentum. Finally, we consider how higher soft limits lead to identities satisfied by correlation functions in large-scale structure.

  20. Multiple soft limits of cosmological correlation functions

    Energy Technology Data Exchange (ETDEWEB)

    Joyce, Austin [Enrico Fermi Institute and Kavli Institute for Cosmological Physics, University of Chicago, Chicago, IL 60637 (United States); Khoury, Justin [Center for Particle Cosmology, Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104 (United States); Simonović, Marko, E-mail: ajoy@uchicago.edu, E-mail: jkhoury@sas.upenn.edu, E-mail: msimonov@sissa.it [SISSA, via Bonomea 265, 34136, Trieste (Italy)

    2015-01-01

    We derive novel identities satisfied by inflationary correlation functions in the limit where two external momenta are taken to be small. We derive these statements in two ways: using background-wave arguments and as Ward identities following from the fixed-time path integral. Interestingly, these identities allow us to constrain some of the O(q{sup 2}) components of the soft limit, in contrast to their single-soft analogues. We provide several nontrivial checks of our identities both in the context of resonant non-Gaussianities and in small sound speed models. Additionally, we extend the relation at lowest order in external momenta to arbitrarily many soft legs, and comment on the many-soft extension at higher orders in the soft momentum. Finally, we consider how higher soft limits lead to identities satisfied by correlation functions in large-scale structure.