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Home; Journals; Journal of Biosciences; Volume 34; Issue 2 ... (peptides A, B, C, and D) were selected using a phage display 12-mer peptide library. ... School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, Jiangsu 214122, ...

Vitamin D as an anti-microbial and anti-inflammatory therapy for Cystic Fibrosis.

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Herscovitch, K; Dauletbaev, N; Lands, Larry C

2014-06-01

Cystic fibrosis (CF) is characterized by chronic infection and inflammation in the airways that lead to progressive lung damage and early death. Current anti-inflammatory therapies are limited by extensive adverse effects or insufficient efficacy. There is a large body of studies indicating beneficial anti-microbial and anti-inflammatory properties of vitamin D. Since most patients with CF present with vitamin D deficiency, and serum vitamin D levels demonstrate a positive correlation with lung function and negative correlation with airway inflammation and infection, correcting vitamin D deficiency may be an attractive therapeutic strategy in CF. The function of vitamin D is intricately tied to its metabolism, which may be impaired at multiple steps in patients with CF, with a potential to limit the efficacy of vitamin D supplementation. It is likely that the aforementioned beneficial properties of vitamin D require supplementation with doses of vitamin D markedly higher than those recommended to maintain proper bone function. This review will illustrate the potential for supplementation with vitamin D or its metabolites to modulate inflammation and improve defence against chronic infection in CF lung, as well as appropriate vitamin D supplementation strategies for improving lung function in CF. Copyright © 2013 Elsevier Ltd. All rights reserved.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 41; Issue 3 ... Asthma is a chronic disease due to inflammation of the airways of lungs that is clinically ... ACE insertion/deletion (I/D) polymorphism, rs4646994, in asthma in Pakistani patients.

Investigation of the decays anti B0 → D*+l-anti ν and anti B → D**l-anti ν

International Nuclear Information System (INIS)

Albrecht, H.; Ehrlichmann, H.; Hamacher, T.; Hofmann, R.P.; Kirchhoff, T.; Nau, A.; Nowak, S.; Schroeder, H.; Schulz, H.D.; Walter, M.; Wurth, R.; Appuhn, R.D.; Hast, C.; Kolanoski, H.; Lange, A.; Lindner, A.; Mankel, R.; Schieber, M.; Siegmund, T.; Spaan, B.; Thurn, H.; Toepfer, D.; Walther, A.; Wegener, D.; Britton, D.I.; Charlesworth, C.E.K.; Edwards, K.W.; Hyatt, E.R.F.; Kapitza, H.; Krieger, P.; MacFarlane, D.B.; Patel, P.M.; Prentice, J.D.; Saull, P.R.B.; Tzamariudaki, K.; Van de Water, R.G.; Yoon, T.S.; Ressing, D.; Schmidtler, M.; Schneider, M.; Schubert, K.R.; Strahl, K.; Waldi, R.; Weseler, S.

1993-01-01

Exclusive semileptonic B decays with a D *+ meson in the final state have been studied using the ARGUS detector at the DORIS II storage ring. The branching ratio for the decay anti B 0 →D *+ l - anti ν, where l - is either e - or μ - , has been measured to be (5.2±0.5±0.6)%. A significant rate for the decay anti B→D ** l - anti ν has been observed. From an angular analysis of the cascade anti B 0 →D *+ (→D 0 π + )l - anti ν the forward-backward asymmetry A FB and the D *+ polarization parameter α have been determined to be A FB =0.20±0.08±0.06 and α=1.1±0.4±0.2. (orig.)

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 39; Issue 5. Evolution and expression analysis of the soybean glutamate decarboxylase gene family ... Although plant GAD plays important roles in GABA biosynthesis, our knowledge concerning GAD gene family members and their evolutionary relationship remains limited.

Sandia National Laboratories: Research: Bioscience

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biological agents. We integrate our renowned engineering, nanotechnology, and computational capabilities to Foundations Bioscience Computing & Information Science Electromagnetics Engineering Science Geoscience Opportunities Microsensors Bioscience Leadership Computing and Information Science Engineering Science

Supersymmetric D2 anti-D2 Strings

OpenAIRE

Bak, Dongsu; Ohta, Nobuyoshi

2001-01-01

We consider the flat supersymmetric D2 and anti-D2 system, which follows from ordinary noncommutative D2 anti-D2 branes by turning on an appropriate worldvolume electric field describing dissolved fundamental strings. We study the strings stretched between D2 and anti-D2 branes and show explicitly that the would-be tachyonic states become massless. We compute the string spectrum and clarify the induced noncommutativity on the worldvolume. The results are compared with the matrix theory descri...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Cover page gallery. Cover page gallery. Journal of Biosciences. Cover page. Journal of Biosciences. Current Issue : Vol. 43, Issue 1. Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search ...

Has bioscience reconciled mind and body?

Science.gov (United States)

Davies, Carmel; Redmond, Catherine; Toole, Sinead O; Coughlan, Barbara

2016-09-01

The aim of this discursive paper is to explore the question 'has biological science reconciled mind and body?'. This paper has been inspired by the recognition that bioscience has a historical reputation for privileging the body over the mind. The disregard for the mind (emotions and behaviour) cast bioscience within a 'mind-body problem' paradigm. It has also led to inherent limitations in its capacity to contribute to understanding the complex nature of health. This is a discursive paper. Literature from the history and sociology of science and psychoneuroimmunology (1975-2015) inform the arguments in this paper. The historical and sociological literature provides the basis for a socio-cultural debate on mind-body considerations in science since the 1970s. The psychoneuroimmunology literature draws on mind-body bioscientific theory as a way to demonstrate how science is reconciling mind and body and advancing its understanding of the interconnections between emotions, behaviour and health. Using sociological and biological evidence, this paper demonstrates how bioscience is embracing and advancing its understanding of mind-body interconnectedness. It does this by demonstrating the emotional and behavioural alterations that are caused by two common phenomena; prolonged, chronic peripheral inflammation and prolonged psychological stress. The evidence and arguments provided has global currency that advances understanding of the inter-relationship between emotions, behaviour and health. This paper shows how bioscience has reconciled mind and body. In doing so, it has advanced an understanding of science's contribution to the inter-relationship between emotions, behaviour and health. The biological evidence supporting mind-body science has relevance to clinical practice for nurses and other healthcare professions. This paper discusses how this evidence can inform and enhance clinical practice directly and through research, education and policy. © 2015 John Wiley

East Midlands healthcare and bioscience sector strategy appendix 1: healthcare and bioscience res implementation plan

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East Midlands Development Agency

2007-01-01

The healthcare and bioscience sector is one of four priority sectors identified in the regional economic strategy, A Flourishing Region. This document sets out the implementation plan for maximising the contribution of the healthcare and biosciences sector to the economic development of the East Midlands.

anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV decays in QCD factorization and possible puzzles

International Nuclear Information System (INIS)

Chang, Qin; Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling

2016-01-01

Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B_d_,_s → D"*_d_,_sV and anti B"*_d_,_s → D_d_,_sV (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B_d_,_s → D"*_d_,_sV decays, the tensions between theoretical results and experimental measurements, i.e. the ''R_d_s"V puzzle'' and ''D*V (or R_V_/_l _a_n_t_i _ν__l_) puzzle'', are presented after detailed analyses. For the anti B"*_d_,_s → D_d_,_sV decays, they have relatively large branching fractions of the order >or similar O(10"-"9) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R_d_s"'"V and R"'_V_/_l _a_n_t_i _ν__l_. More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

Anti-G with concomitant anti-C and anti-D: A case report in a pregnant woman.

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Yousuf, Rabeya; Mustafa, Ahmad Nasirudin; Ho, Siew-Ling; Tang, Yee-Loong; Leong, Chooi-Fun

2017-01-01

The G antigen of Rh blood group system is present in almost all D-positive or C-positive red cells but absent from red cells lacking D and C antigens. The differentiation of anti-D and anti-C from anti-G is not necessary for routine transfusion; however, during pregnancy, it is important because anti-G can masquerade as anti-D and anti-C with initial antibody testing. The false presence of anti-D will exclude the patient from receiving anti-D immunoglobulin (RhIG) when the patient actually is a candidate for RhIG prophylaxis. Moreover, patients with positive anti-D or anti-G are at risk of developing hemolytic disease of the fetus and newborn and need close monitoring. Thus, proper identification allows the clinicians to manage patients properly. This case report highlights a rare case of anti-G together with anti-D and anti-C in a pregnant woman. This report disseminates knowledge on identification of anti-G and its importance in pregnant women.

Production of d, t, 3He, anti d, anti t and anti 3He by 200 GeV protons

International Nuclear Information System (INIS)

Bozzoli, W.; Giacomelli, G.; Rimondi, F.; Zylberajch, S.; Lesquoy, E.; Meunier, R.; Moscoso, L.; Muller, A.; Bussiere, A.

1978-01-01

Data are presented on the yields of d, t, 3 He, anti d, anti t, and anti 3 He with laboratory momenta between 12 and 37 GeV/c produced by 200 GeV protons on beryllium and aluminium. The production yield of nuclei depends significantly on the target nucleus, while the anti d production is independent of target material. The mass dependence of the production cross section is exponential for both nuclei and antinuclei

Anti-G with concomitant anti-C and anti-D: A case report in a pregnant woman

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Rabeya Yousuf

2017-01-01

Full Text Available The G antigen of Rh blood group system is present in almost all D-positive or C-positive red cells but absent from red cells lacking D and C antigens. The differentiation of anti-D and anti-C from anti-G is not necessary for routine transfusion; however, during pregnancy, it is important because anti-G can masquerade as anti-D and anti-C with initial antibody testing. The false presence of anti-D will exclude the patient from receiving anti-D immunoglobulin (RhIG when the patient actually is a candidate for RhIG prophylaxis. Moreover, patients with positive anti-D or anti-G are at risk of developing hemolytic disease of the fetus and newborn and need close monitoring. Thus, proper identification allows the clinicians to manage patients properly. This case report highlights a rare case of anti-G together with anti-D and anti-C in a pregnant woman. This report disseminates knowledge on identification of anti-G and its importance in pregnant women.

Possible D(*) anti D(*) and B(*) anti B(*) molecular states in the extended constituent quark models

International Nuclear Information System (INIS)

Yang, You-Chang; Tan, Zhi-Yun; Ping, Jialun; Zong, Hong-Shi

2017-01-01

The possible neutral D (*) anti D (*) and B (*) anti B (*) molecular states are studied in the framework of the constituent quark models, which is extended by including the s-channel one-gluon exchange. Using different types of quark-quark potentials, we solve the four-body Schroedinger equation by means of the Gaussian expansion method. The bound states of D (*) anti D (*) with J PC = 1 ++ , 2 ++ and B (*) anti B (*) with J PC = 0 ++ , 1 +- , 1 ++ , 2 ++ are obtained. The molecular states D* anti D with J PC = 1 ++ and B* anti B with J PC = 1 +- are good candidates for X(3872) and Z 0 b (10610), respectively. The dependence of the results on the model parameters is also discussed. (orig.)

The restricted use of IGHV3 superspecies genes in anti-Rh is not limited to hyperimmunized anti-D donors

NARCIS (Netherlands)

Dohmen, Serge E.; Verhagen, Onno J. H. M.; Muit, Jessica; Ligthart, Peter C.; van der Schoot, C. Ellen

2006-01-01

BACKGROUND: Antibodies produced against the D antigen make use of IGHV genes restricted to the IGHV3 superfamily. These findings are based on the IGHV gene analysis in anti-D-producing B cells from hyperimmunized donors, however, and therefore the restriction might be due to the hyperimmunization.

B{sup 0} → D{sup 0} anti D{sup 0}K{sup 0}, B{sup +} → D{sup 0} anti D{sup 0}K{sup +}, and the scalar D anti D bound state

Energy Technology Data Exchange (ETDEWEB)

Dai, L.R. [Liaoning Normal University, Department of Physics, Dalian (China); Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Xie, Ju-Jun [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Oset, E. [Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain); Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China)

2016-03-15

We study the B{sup 0} decay to D{sup 0} anti D{sup 0}K{sup 0} based on the chiral unitary approach, which generates the X(3720) resonance, and we make predictions for the D{sup 0} anti D{sup 0} invariant mass distribution. From the shape of the distribution, the existence of the resonance below threshold could be induced. We also predict the rate of production of the X(3720) resonance to the D{sup 0} anti D{sup 0} mass distribution with no free parameters. (orig.)

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

Science.gov (United States)

Kapur, Rick; Della Valle, Luciana; Verhagen, Onno J H M; Hipgrave Ederveen, Agnes; Ligthart, Peter; de Haas, Masja; Kumpel, Belinda; Wuhrer, Manfred; van der Schoot, C Ellen; Vidarsson, Gestur

2015-03-01

RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III. Levels of immunoglobulin (Ig)G Fc-fucosylation influence interactions with FcγRIII, with less Fc-fucosylation strengthening the interaction. Anti-D IgG1 Fc-glycosylation patterns in 93 plasma samples from 28 male and 28 female Dutch HIDs and RhIG were analyzed with mass spectrometry. The Fc-glycosylation profiles of HIDs were evaluated with regard to their immunization history. HID sera demonstrated clearly lowered anti-D Fc-fucosylation compared to normal IgG fucosylation (93%); this was more pronounced for female than for male HIDs (47% vs. 65%, p = 0.001). RhIG preparations from seven manufacturers varied greatly in the level of Fc-fucosylation (56%-91%). The level of fucosylation slightly increased upon repeated immunization, although it remained fairly constant over time. The RhIG from the different manufacturers all demonstrated increased Fc-galactosylation (64%-82%) compared to total IgG (38%-51%). RhIG preparations vary in Fc-fucosylation and all demonstrate increased galactosylation. Despite not knowing the exact working mechanism, immunoprophylaxis could perhaps be optimized by selection of donors whose anti-D have low amounts of Fc-fucose, to increase the clearance activity of anti-D preparations, as well as high amounts of galactosylation, for anti-inflammatory effects. Implementing a biologic assay in the standardization of RhIG preparations might be considered. © 2014 AABB.

What is it really? Anti-G or Anti-D plus Anti-C: Clinical Significance in Antenatal Mothers.

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Das, Soumya; Shastry, Shamee; Murugesan, M; B, Poornima Baliga; Shastry, Shamee

2017-06-01

G antigen of Rh blood group system is present either along with D and/or C positive red cells. Hence, [serologically anti-G presents with the similar picture as that of multiple antibodies (anti-D + anti-C). Differentiating them is important as anti-D + anti-C causes severe hemolytic disease of the fetus and newborn than anti-G. In pregnancies with anti-G alone, alloimmunization due to D antigen could be prevented by prophylactic administration of RhIg. Differentiating between anti-D + C from anti-G in alloimmunized pregnant mothers becomes essential. Sera from antenatal mothers, whose antibody identification by 11-cell panel gave a pattern for anti-D and anti-C were selected. Extended phenotyping for Rh system was performed for these antenatal cases. Differential adsorption and elution testing using R 2 R 2 cells initially and r'r cells subsequently were performed to distinguish anit-G from anti-D + anti-C. Antibody titers of these antibodies were determined and their clinical outcome in the newborn was followed. A pattern suggestive of anti D and anti C on antibody identification were observed in six antenatal cases. On further workup 50 % of them confirmed to have anti G. Antibody titers of anti-G and anti-C were lower than that of Anti-D. All newborns were sensitized in vivo and the antibody specificity in them were confirmed with elution studies. The mothers who had only anti-G were subsequently administered with an appropriate dose of RhIg.Differential adsorption and elution studies help in identifying anti-G and distinguishing it from anti-D plus anti-C, thus helping in better patient management.

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Home; Journals; Journal of Biosciences. Madhuri Thakar. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 515-525. HIV infection in India: Epidemiology, molecular epidemiology and pathogenesis. Samir Lakhashe Madhuri Thakar Sheela Godbole Srikanth Tripathy Ramesh Paranjape.

The prozone effect exerted by the complement-binding anti-Lea on anti-D.

Science.gov (United States)

Joshi, Sanmukh R; Parekh, Kamlesh H

2017-01-01

Prozone phenomenon is seen with very high-titer antibodies in an immune serum. The prozone effect on anti-D by a low-titer anti-Le a was investigated associated with neonatal jaundice. Standard methods were used in investigations. The child was born at full-term developed mild jaundice. With weak direct antiglobulin test+, her indirect serum bilirubin was progressed to 27.5 mg/dL in 48 h. Anti-D and anti-Le a were detected in the mother. Both these antibodies were detected in the child's serum though the eluate from red blood cells (RBCs) contained only anti-D. Mother's anti-D was masked by anti-Le a if the RBCs possessed both the antigens together. Anti-D was revealed only with D-positive RBCs lacking Le a or if the serum was modified by mixing with Le a+ saliva or was heated at 56°C or fortified with citrate solution. An anti-D showed prozone effect exerted by the complement-fixing anti-Le a in the test.

Low frequency of anti-D alloimmunization following D+ platelet transfusion: the Anti-D Alloimmunization after D-incompatible Platelet Transfusions (ADAPT) study.

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Cid, Joan; Lozano, Miguel; Ziman, Alyssa; West, Kamille A; O'Brien, Kerry L; Murphy, Michael F; Wendel, Silvano; Vázquez, Alejandro; Ortín, Xavier; Hervig, Tor A; Delaney, Meghan; Flegel, Willy A; Yazer, Mark H

2015-02-01

The reported frequency of D alloimmunization in D- recipients after transfusion of D+ platelets varies. This study was designed to determine the frequency of D alloimmunization, previously reported to be an average of 5 ± 2%. A primary anti-D immune response was defined as the detection of anti-D ≥ 28 d following the first D+ platelet transfusion. Data were collected on 485 D- recipients of D+ platelets in 11 centres between 2010 and 2012. Their median age was 60 (range 2-100) years. Diagnoses included: haematological (203/485, 42%), oncological (64/485, 13%) and other diseases (218/485, 45%). Only 7/485 (1·44%; 95% CI 0·58-2·97%) recipients had a primary anti-D response after a median serological follow-up of 77 d (range: 28-2111). There were no statistically significant differences between the primary anti-D formers and the other patients, in terms of gender, age, receipt of immunosuppressive therapy, proportion of patients with haematological/oncological diseases, transfusion of whole blood-derived or apheresis platelets or both, and total number of transfused platelet products. This is the largest study with the longest follow-up of D alloimmunization following D+ platelet transfusion. The low frequency of D alloimmunization should be considered when deciding whether to administer Rh Immune Globulin to D- males and D- females without childbearing potential after transfusion of D+ platelets. © 2014 John Wiley & Sons Ltd.

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East Midlands healthcare and bioscience sector strategy

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East Midlands Development Agency

2007-01-01

The healthcare and bioscience sector is one of four priority sectors identified in the regional economic strategy, A Flourishing Region. This document sets out a strategy for maximising the contribution of the healthcare and biosciences sector to the economic development of the East Midlands.

Anti-D Antibodies in Pregnant D Variant Antigen Carriers Initially Typed as RhD.

Science.gov (United States)

Lukacevic Krstic, Jelena; Dajak, Slavica; Bingulac-Popovic, Jasna; Dogic, Vesna; Mratinovic-Mikulandra, Jela

2016-11-01

To evaluate the incidence, the consequences, and the prevention strategy of anti-D alloimmunizations of D variant carriers in the obstetric population of Split-Dalmatia County, Croatia. RhD immunization events were evaluated retrospectively for the period between 1993 and 2012. Women were tested for RhD antigen and irregular antibodies. Those with anti-D antibody who were not serologically D- were genotyped for RHD. They were evaluated for their obstetric and transfusion history and their titer of anti-D. The neonates were evaluated for RhD status, direct antiglobulin test (DAT), hemoglobin and bilirubin levels, transfusion therapy as well as phototherapy and outcome. Out of 104,884 live births 102,982 women were tested for RhD antigen. Anti-D immunization occurred in 184 women which accounts for 0.9% of individuals at risk of anti-D formation. 181 cases occurred in women serologically typed as D-. Three women were partial D carriers (DVa n = 2, DNB n = 1), initially typed RhD+, and recognized as D variant carriers after the immunization occurred. Anti-D titer varied from 1:1 to 1:16. Six children were RhD+, four had positive DAT, and two underwent phototherapy. Anti-D immunization occurred in pregnant partial D carriers (DVa, DNB). RhD+ children had serologic markers of hemolytic disease of the fetus and newborn (HDFN), with no cases of severe HDFN.

Hemolytic disease of the fetus and newborn caused by anti-D and anti-S alloantibodies: a case report

Directory of Open Access Journals (Sweden)

Yousuf Rabeya

2012-02-01

Full Text Available Abstract Introduction Hemolytic disease of the fetus and newborn is most commonly caused by anti-D alloantibody. It is usually seen in Rhesus D (RhD-negative mothers that have been previously sensitized. We report here a case of hemolytic disease of the fetus and newborn in a newborn baby caused by anti-D and anti-S alloantibodies, born to a mother who was RhD negative, but with no previous serological evidence of RhD alloimmunization. Case presentation A one-day-old Chinese baby boy was born to a mother who was group A RhD negative. The baby was jaundiced with hyperbilirubinemia, but with no evidence of infection. His blood group was group A RhD positive, his direct Coombs' test result was positive and red cell elution studies demonstrated the presence of anti-D and anti-S alloantibodies. Investigations performed on the maternal blood during the 22 weeks of gestation showed the presence of anti-S antibodies only. Repeat investigations performed post-natally showed the presence of similar antibodies as in the newborn and an anti-D titer of 1:32 (0.25 IU/mL, which was significant. A diagnosis of hemolytic disease of the fetus and newborn secondary to anti-D and anti-S was made. The baby was treated with phototherapy and close monitoring. He was discharged well after five days of phototherapy. Conclusions This case illustrates the possibility of an anamnestic response of allo-anti-D from previous sensitization in a RhD-negative mother, or the development of anti-D in mid-trimester. Thus, it highlights the importance of thorough antenatal ABO, RhD blood grouping and antibody screening, and if necessary, antibody identification and regular monitoring of antibody screening and antibody levels for prevention or early detection of hemolytic disease of the fetus and newborn, especially in cases of mothers with clinically significant red cell alloantibody.

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Search for ZX → ν anti ν b anti b Events in the D-Zero Detector

International Nuclear Information System (INIS)

Abbott, B.

1997-10-01

We report on a search for a new particle, X, decaying via X → b anti b, made through associated production with a Z boson. We use data collected with the D0 detector operating at the Fermilab Tevatron p anti p collider with √s = 1.8 TeV. We utilize muon-tagged jets to identify b-quarks and the ν anti ν channel to detect Z bosons. Preliminary results on cross section limits for X masses between 90 GeV/c 2 and 180 GeV/c 2 are presented

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Home; Journals; Journal of Biosciences. Isaac Salazar-Ciudad. Articles written in Journal of Biosciences. Volume 34 Issue 4 October 2009 pp 573-587 Articles. Looking at the origin of phenotypic variation from pattern formation gene networks · Isaac Salazar-Ciudad · More Details Abstract Fulltext PDF. This article critically ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Journal of Biosciences. Current Issue : Vol. 43, Issue 1 · Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search · Online submission at eBiosciences · Editorial Board · Information for Authors · Subscription ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Sebastian Fettig. Articles written in Journal of Biosciences. Volume 32 Issue 3 April 2007 pp 501-510 Articles. specific and unspecific responses of plants to cold and drought stress · Erwin H Beck Sebastian Fettig Claudia Knake Katja Hartig Tribikram Bhattarai · More Details Abstract ...

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Home; Journals; Journal of Biosciences. XIAOQIAN DING. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 637-645 Article. MicroRNA-146 protects A549 and H1975 cells from LPS-induced apoptosis and inflammation injury · QIANG WANG DAGANG LI YUQUAN HAN XIAOQIAN DING TAO ...

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Home; Journals; Journal of Biosciences. Odir A Dellagostin. Articles written in Journal of Biosciences. Volume 33 Issue 3 September 2008 pp 355-363 Articles. Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds · Luciano S Pinto Celso S Nagano Taianá M Oliveira Tales R ...

Journal of Biosciences | Indian Academy of Sciences

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Journal of Biosciences. Current Issue : Vol. 43, Issue 1. Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search · Online submission at eBiosciences · Editorial Board · Information for Authors · Subscription ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. P Dayanandan. Articles written in Journal of Biosciences. Volume 28 Issue 4 June 2003 pp 455-469 Articles. Structural and histochemical studies on grain-filling in the caryopsis of rice (Oryza sativa L.) S Krishnan P Dayanandan · More Details Abstract Fulltext PDF. The endosperm ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. QING-XIAN HUANG. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 547-554 Article. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway · LI-MIN FENG XUE-FENG WANG ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. P Chauhan. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 729-747 Articles. India at the cross-roads of human evolution · R Patnaik P Chauhan · More Details Abstract Fulltext PDF. The Indian palaeoanthropological record, although patchy at the ...

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Home; Journals; Journal of Biosciences. A Sahni. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 673-686 Articles. The origin and early evolution of whales: macroevolution documented on the Indian Subcontinent · S Bajpai J G M Thewissen A Sahni · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. Victor Smetacek. Articles written in Journal of Biosciences. Volume 37 Issue 4 September 2012 pp 589-607 Perspectives. Making sense of ocean biota: How evolution and biodiversity of land organisms differ from that of the plankton · Victor Smetacek · More Details Abstract Fulltext ...

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Home; Journals; Journal of Biosciences. Marta Linde-Medina. Articles written in Journal of Biosciences. Volume 36 Issue 4 September 2011 pp 575-585 Brief communication. Adaptation or exaptation? The case of the human hand · Marta Linde-Medina · More Details Abstract Fulltext PDF. A controversy of relevance to the ...

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Home; Journals; Journal of Biosciences. ASHIS KUMAR NANDI. Articles written in Journal of Biosciences. Volume 38 Issue 3 September 2013 pp 583-592 Articles. Down-regulation of OsSAG12-1 results in enhanced senescence and pathogen-induced cell death in transgenic rice plants · Subaran Singh Mrunmay Kumar ...

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Home; Journals; Journal of Biosciences. Triptish Bhatia. Articles written in Journal of Biosciences. Volume 27 Issue 1 February 2002 pp 35-52. Molecular genetics of schizophrenia: past, present and future · Suman Prasad Prachi Semwal Smita Deshpande Triptish Bhatia V L Nimgaonkar B K Thelma · More Details Abstract ...

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Home; Journals; Journal of Biosciences. David L Beveridge. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 379-397 Articles. The ABCs of molecular dynamics simulations on B-DNA, circa 2012 · David L Beveridge Thomas E Cheatham III Mihaly Mezei · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. S A Kulasooriya. Articles written in Journal of Biosciences. Volume 31 Issue 5 December 2006 pp 645-650 Reviews. Interactions among endophytic bacteria and fungi: effects and potentials · W M M S Bandara Gamini Seneviratne S A Kulasooriya · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. Ardashir K Masouleh. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 829-841 Articles. Application of large-scale sequencing to marker discovery in plants · Robert J Henry Mark Edwards Daniel L E Waters S Gopala Krishnan Peter Bundock Timothy ...

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Home; Journals; Journal of Biosciences. Manjula Kalia. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 451-464. Molecular biology and pathogenesis of hepatitis E virus · Vivek Chandra Shikha Taneja Manjula Kalia Shahid Jameel · More Details Abstract Fulltext PDF. The hepatitis E virus ...

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Home; Journals; Journal of Biosciences. L Singh. Articles written in Journal of Biosciences. Volume 36 Issue 4 September 2011 pp 739-748 Review. Mango ginger (Curcuma amada Roxb.) – A promising spice for phytochemicals and biological activities · R S Policegoudra S M Aradhya L Singh · More Details Abstract ...

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Home; Journals; Journal of Biosciences. Saqib Mahmood. Articles written in Journal of Biosciences. Volume 40 Issue 3 September 2015 pp 521-530 Articles. Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity · Adeela Shahid Sobia Rana Saqib Mahmood Shahid Saeed · More Details ...

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Home; Journals; Journal of Biosciences. Sinha Sinha. Articles written in Journal of Biosciences. Volume 39 Issue 3 June 2014 pp 525-536 Reviews. Conservation of PHO pathway in ascomycetes and the role of Pho84 · Parul Tomar Sinha Sinha · More Details Abstract Fulltext PDF. In budding yeast, Saccharomyces ...

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Home; Journals; Journal of Biosciences. Amrita Banerjee. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 475-481 Articles. A revisit of the mode of interaction of small transcription inhibitors with genomic DNA · Dipak Dasgupta Parijat Majumder Amrita Banerjee · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. Girish J Kotwal. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 265-271 Articles. Vaccinia complement control protein: Multi-functional protein and a potential wonder drug · Purushottam Jha Girish J Kotwal · More Details Abstract Fulltext PDF. Vaccinia ...

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Home; Journals; Journal of Biosciences. Gavan Holloway. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 323-335 Articles. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication · Alison L Greenway Gavan Holloway Dale A McPhee Phoebe Ellis Alyssa ...

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Home; Journals; Journal of Biosciences. Vibha Tandon. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 493-502 Articles. Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme · Nirpendra Singh Atul Ranjan Souvik Sur Ramesh Chandra Vibha Tandon · More Details Abstract Fulltext ...

Approach to a Pregnant Woman with Anti D + Anti C Reactivity Pattern: A Diagnostic Conundrum.

Science.gov (United States)

Rai, Preeti; Sharma, Geetika; Singh, Deeksha; Garg, Jyoti

2017-09-01

The Rhesus G antigen is present on all RBCs that are C+ and also on most D+ RBCs. Due to this co-distribution of G with either C or D antigen, it mimics a reactivity pattern of anti C + anti D on Indirect Antiglobulin Test (IAT), though the role of Anti G in causing Hemolytic Disease of Newborn (HDN) is controversial. The differentiation of anti D, anti C, and anti G is essential particularly in pregnant females. We hereby report a rare case of anti G with anti D and anti C in a pregnant woman with emphasis on approach to identify anti D+C+G and its implications.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Satish K Amarnath. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 539-547. Brucellosis in India – a review · Basappa G Mantur Satish K Amarnath · More Details Abstract Fulltext PDF. Brucellosis is an important re-emerging zoonosis with a ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Baby P S Chakrapani. Articles written in Journal of Biosciences. Volume 33 Issue 2 June 2008 pp 269-277 Articles. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression · Baby P S ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. John Bernet. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 249-264 Articles. Viral mimicry of the complement system · John Bernet Jayati Mullick Akhilesh K Singh Arvind Sahu · More Details Abstract Fulltext PDF. The complement system is a potent ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Carissa Reason. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 389-398 Articles. Declines of seagrasses in a tropical harbour, North Queensland, Australia, are not the result of a single event · Skye McKenna Jessie Jarvis Tonia Sankey Carissa Reason ...

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Home; Journals; Journal of Biosciences. Anil K Gupta. Articles written in Journal of Biosciences. Volume 27 Issue 7 December 2002 pp 703-714 Review Article. Applications of inulin and oligofructose in health and nutrition · Narinder Kaur Anil K Gupta · More Details Abstract Fulltext PDF. Inulin and oligofructose belong to a ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. S A Ranade. Articles written in Journal of Biosciences. Volume 25 Issue 3 September 2000 pp 291-299 Review articles. Role of polyamines and ethylene as modulators of plant senescence · S Pandey S A Ranade P K Nagar Nikhil Kumar · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. Subrata Basu Ray. Articles written in Journal of Biosciences. Volume 26 Issue 5 December 2001 pp 555-559. Commentary: The enigma of morphine tolerance: recent insights · Subrata Basu Ray Shashi Wadhwa · More Details Fulltext PDF. Volume 29 Issue 1 March 2004 pp 51-56 ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Hsinyu Lee. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 157-165 Review. Autophagy: A double-edged sword in Alzheimer's disease · Ying-Tsen Tung Bo-Jeng Wang Ming-Kuan Hu Wen-Ming Hsu Hsinyu Lee Wei-Pang Huang Yung-Feng Liao.

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Lidia Andreu Guillo. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 33-39 Articles. TP53 codon 72 polymorphism in pigmentary phenotypes · Kárita Antunes Costa Lidia Andreu Guillo · More Details Abstract Fulltext PDF. The p53 protein exerts different ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Shobha Rao. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 481-489. Nutritional status of the Indian population · Shobha Rao · More Details Abstract Fulltext PDF. High prevalence of low birth weight, high morbidity and mortality in children and poor ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. LI-MIN FENG. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 547-554 Article. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway · LI-MIN FENG XUE-FENG WANG QING-XIAN ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Naveen Kumar Nair. Articles written in Journal of Biosciences. Volume 37 Issue 2 June 2012 pp 301-312 Review. Nucleic acids in circulation: Are they harmful to the host? Indraneel Mittra Naveen Kumar Nair Pradyumna Kumar Mishra · More Details Abstract Fulltext PDF. It has been ...

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Home; Journals; Journal of Biosciences. M T Tanuja. Articles written in Journal of Biosciences. Volume 26 Issue 1 March 2001 pp 71-76 Articles. Incipient sexual isolation in the nasuta-albomicans complex of Drosophila: No-choice experiments · M T Tanuja N B Ramachandra H A Ranganath · More Details Abstract Fulltext ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Carlos Sonnenschein. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 103-118. Emergentism as a default: Cancer as a problem of tissue organization · Ana M soto Carlos Sonnenschein · More Details Abstract Fulltext PDF. During the last fifty years the ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Mihaly Mezei. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 379-397 Articles. The ABCs of molecular dynamics simulations on B-DNA, circa 2012 · David L Beveridge Thomas E Cheatham III Mihaly Mezei · More Details Abstract Fulltext PDF. This article ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. SONG XUE. Articles written in Journal of Biosciences. Volume 41 Issue 2 June 2016 pp 229-236 Article. Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells · Zhan Shi Ding Wu Run Tang Xiang Li Renfu Chen Song Xue Chengjing ...

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Home; Journals; Journal of Biosciences. Scott F Gilbert. Articles written in Journal of Biosciences. Volume 26 Issue 3 September 2001 pp 293-298. Commentary: New vistas for developmental biology · Scott F Gilbert Rocky S Tuan · More Details Fulltext PDF. Volume 27 Issue 5 September 2002 pp 445-446. Commentary: ...

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Home; Journals; Journal of Biosciences. Satya Keerthi Kota. Articles written in Journal of Biosciences. Volume 30 Issue 3 June 2005 pp 329-337 Articles. Cloning and characterization of mouse cullin4B/E3 ubiquitin ligase · Rachana Tripathi K Seetharama Satya Keerthi Kota Usha K Srinivas · More Details Abstract Fulltext ...

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Home; Journals; Journal of Biosciences. Sangappa. Articles written in Journal of Biosciences. Volume 30 Issue 2 March 2005 pp 259-268 Articles. Crystal structure of raw pure Mysore silk fibre based on (Ala-Gly)2-Ser-Gly peptide sequence using Linked-Atom-Least-Squares method · Sangappa S S Mahesh R Somashekar.

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. G Keller. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 709-728 Articles. Deccan volcanism, the KT mass extinction and dinosaurs · G Keller A Sahni S Bajpai · More Details Abstract Fulltext PDF. Recent advances in Deccan volcanic studies indicate ...

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Home; Journals; Journal of Biosciences. G V R Prasad. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 649-659 Articles. Divergence time estimates of mammals from molecular clocks and fossils: Relevance of new fossil finds from India · G V R Prasad · More Details Abstract Fulltext PDF.

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Home; Journals; Journal of Biosciences. Rahul Gaur. Articles written in Journal of Biosciences. Volume 32 Issue 4 June 2007 pp 747-754 Articles. Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block · Rahul Gaur Glenn R Björk Simon Tuck Umesh Varshney.

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Home; Journals; Journal of Biosciences. Michel Morange. Articles written in Journal of Biosciences. Volume 29 Issue 4 December 2004 pp 378-380. Commentary: The death of Francis Crick: the end of a golden age in biology · Michel Morange · More Details Fulltext PDF. Volume 30 Issue 3 June 2005 pp 313-316 Series.

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Home; Journals; Journal of Biosciences. Devarshi U Gajjar. Articles written in Journal of Biosciences. Volume 37 Issue 6 December 2012 pp 979-987 Articles. Cx43, ZO-1, alpha-catenin and beta-catenin in cataractous lens epithelial cells · Anshul I Arora Kaid Johar Devarshi U Gajjar Darshini A Ganatra Forum B Kayastha ...

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Home; Journals; Journal of Biosciences. Lei He. Articles written in Journal of Biosciences. Volume 39 Issue 1 March 2014 pp 63-74 Articles. Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis · Chengcheng Zhang Lei He Kai Kang Heng Chen ...

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Home; Journals; Journal of Biosciences. Chen Fang. Articles written in Journal of Biosciences. Volume 30 Issue 3 June 2005 pp 351-357 Articles. Expression of a ribosome inactivating protein (curcin 2) in Jatropha curcas is induced by stress · Wei Qin Huang Ming-Xing Xu Ying Zhang Xin-Shen Chen Fang · More Details ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. Ana M soto. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 103-118. Emergentism as a default: Cancer as a problem of tissue organization · Ana M soto Carlos Sonnenschein · More Details Abstract Fulltext PDF. During the last fifty years the dominant ...

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Home; Journals; Journal of Biosciences. Julio Reyes Leyva. Articles written in Journal of Biosciences. Volume 37 Issue 6 December 2012 pp 999-1004 Articles. Sialyl Lewis x expression in cervical scrapes of premalignant lesions · Noé Velázquez-Márquez Gerardo Santos López Lucio Jiménez Aranda Julio Reyes Leyva ...

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Home; Journals; Journal of Biosciences. Partha P Majumder. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 390a-390a. Preface · Partha P Majumder A Jagannadha Rao · More Details Fulltext PDF. Volume 26 Issue 4 November 2001 pp 533-545. Ethnic populations of India as seen from ...

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Home; Journals; Journal of Biosciences. Amar J S Klar. Articles written in Journal of Biosciences. Volume 35 Issue 1 March 2010 pp 11-15 Perspectives. A proposal for re-defining the way the aetiology of schizophrenia and bipolar human psychiatric diseases is investigated · Amar J S Klar · More Details Abstract Fulltext ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. SUMITRA NAIN. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 481-490 Article. Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND · HARI OM SINGH ...

Youtube for millennial nursing students; using internet technology to support student engagement with bioscience.

Science.gov (United States)

Johnston, Amy Nb; Barton, Matthew J; Williams-Pritchard, Grant A; Todorovic, Michael

2018-06-09

Undergraduate nursing programs typically include students with limited 'on-campus' time who need learning resources that are flexible, technologically appropriate, remotely-accessible (mobile smart devices), and above all, engaging. This has presented academics with challenges surrounding institutional security firewalls, password-access requirements, intellectual property/ownership and staff/student privacy. To overcome these challenges a collection of evidence-based YouTube videos, posted on the Biological Sciences YouTube Channel, supported by the Biosciences in Nurse Education, and underpinned by Benner's pedagogical framework, were developed with the intention of moving students from novice to competent clinical bioscience users. The videos are highly successful; with over 310,000 views, 1.5 million minutes of viewing and more than 5000 subscribers since its inception (YouTube videos was enhanced by their familiarity with the presenter and the breadth of information available in small portions, creating a solid basis for the development of bioscience-competent nursing graduates. Moreover, these open source videos provide a free resource for continual revision and professional development informed by an international minimum bioscience standard for nurses post registration. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

Approach to a Pregnant Woman with Anti D + Anti C Reactivity Pattern: A Diagnostic Conundrum

OpenAIRE

Rai, Preeti; Sharma, Geetika; Singh, Deeksha; Garg, Jyoti

2017-01-01

The Rhesus G antigen is present on all RBCs that are C+ and also on most D+ RBCs. Due to this co-distribution of G with either C or D antigen, it mimics a reactivity pattern of anti C + anti D on Indirect Antiglobulin Test (IAT), though the role of Anti G in causing Hemolytic Disease of Newborn (HDN) is controversial. The differentiation of anti D, anti C, and anti G is essential particularly in pregnant females. We hereby report a rare case of anti G with anti D and anti C in a pregnant woma...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Journal of Biosciences. Volumes & Issues. Volume 43. Issue 1. Mar 2018. Volume 42. Issue 1. Mar 2017; Issue 2. Jun 2017; Issue 3. Sep 2017; Issue 4. Dec 2017. Volume 41. Issue 1. Mar 2016; Issue 2. Jun 2016; Issue 3. Sep 2016; Issue 4. Dec 2016. Volume 40. Issue 1. Mar 2015 ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences. G P Talwar. Articles written in Journal of Biosciences. Volume 30 Issue 4 September 2005 pp 435-447 Perspectives. A destiny to fulfill · G P Talwar · More Details Fulltext PDF. Volume 34 Issue 6 December 2009 pp 909-916 Articles. A partner monoclonal antibody to Moab 730 kills ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. Q M I Haq. Articles written in Journal of Biosciences. Volume 36 Issue 2 June 2011 pp 329-340 Articles. Mutagenesis in ORF AV2 affects viral replication in Mungbean yellow mosaic India virus · A Rouhibakhsh Q M I Haq V G Malathi · More Details Abstract Fulltext PDF. Mungbean ...

anti B{sub d,s} → D{sup *}{sub d,s}V and anti B{sup *}{sub d,s} → D{sub d,s}V decays in QCD factorization and possible puzzles

Energy Technology Data Exchange (ETDEWEB)

Chang, Qin [Henan Normal University, Institute of Particle and Nuclear Physics, Henan (China); Central China Normal University, Institute of Particle Physics, Wuhan (China); Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling [Henan Normal University, Institute of Particle and Nuclear Physics, Henan (China)

2016-10-15

Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B{sub d,s} → D{sup *}{sub d,s}V and anti B{sup *}{sub d,s} → D{sub d,s}V (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B{sub d,s} → D{sup *}{sub d,s}V decays, the tensions between theoretical results and experimental measurements, i.e. the ''R{sub ds}{sup V} puzzle'' and ''D*V (or R{sub V/l} {sub anti} {sub ν{sub l)}} puzzle'', are presented after detailed analyses. For the anti B{sup *}{sub d,s} → D{sub d,s}V decays, they have relatively large branching fractions of the order >or similar O(10{sup -9}) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R{sub ds}{sup 'V} and R{sup '}{sub V/l} {sub anti} {sub ν{sub l.}} More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

murali d bashyam

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences. MURALI D BASHYAM. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 695-707 Review. Multiple oncogenic roles of nuclear beta-catenin · RAJU KUMAR MURALI D BASHYAM · More Details Abstract Fulltext PDF. Beta-Catenin is essential for ...

Possible D{sup (*)} anti D{sup (*)} and B{sup (*)} anti B{sup (*)} molecular states in the extended constituent quark models

Energy Technology Data Exchange (ETDEWEB)

Yang, You-Chang [Nanjing University, Department of Physics, Nanjing (China); Zunyi Normal University, School of Physics and Electronic Science, Zunyi (China); Institute of Theoretical Physics, CAS, State Key Laboratory of Theoretical Physics, Beijing (China); Tan, Zhi-Yun [Zunyi Normal University, School of Physics and Electronic Science, Zunyi (China); Ping, Jialun [Nanjing Normal University, Department of Physics, Nanjing (China); Zong, Hong-Shi [Nanjing University, Department of Physics, Nanjing (China); Institute of Theoretical Physics, CAS, State Key Laboratory of Theoretical Physics, Beijing (China)

2017-09-15

The possible neutral D{sup (*)} anti D{sup (*)} and B{sup (*)} anti B{sup (*)} molecular states are studied in the framework of the constituent quark models, which is extended by including the s-channel one-gluon exchange. Using different types of quark-quark potentials, we solve the four-body Schroedinger equation by means of the Gaussian expansion method. The bound states of D{sup (*)} anti D{sup (*)} with J{sup PC} = 1{sup ++}, 2{sup ++} and B{sup (*)} anti B{sup (*)} with J{sup PC} = 0{sup ++}, 1{sup +-}, 1{sup ++}, 2{sup ++} are obtained. The molecular states D* anti D with J{sup PC} = 1{sup ++} and B* anti B with J{sup PC} = 1{sup +-} are good candidates for X(3872) and Z{sup 0}{sub b}(10610), respectively. The dependence of the results on the model parameters is also discussed. (orig.)

Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography.

Science.gov (United States)

Wegner, Florian; Wilke, Florian; Raab, Peter; Tayeb, Said Ben; Boeck, Anna-Lena; Haense, Cathleen; Trebst, Corinna; Voss, Elke; Schrader, Christoph; Logemann, Frank; Ahrens, Jörg; Leffler, Andreas; Rodriguez-Raecke, Rea; Dengler, Reinhard; Geworski, Lilli; Bengel, Frank M; Berding, Georg; Stangel, Martin; Nabavi, Elham

2014-06-20

Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in 18F-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis. The brain 18F-fluoro-2-deoxy-d-glucose uptake from whole-body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and four patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls. Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti-leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism. This retrospective 18F-fluoro-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis.

Clinical input of anti-D quantitation by continuous-flow analysis on autoanalyzer in the management of high-titer anti-D maternal alloimmunization.

Science.gov (United States)

Toly-Ndour, Cécile; Mourtada, Haifa; Huguet-Jacquot, Stéphanie; Maisonneuve, Emeline; Friszer, Stéphanie; Pernot, Françoise; Thomas, Pauline; Jouannic, Jean-Marie; Carbonne, Bruno; Cortey, Anne; Mailloux, Agnès

2018-02-01

In addition to titration by indirect antiglobulin test most widely used, anti-D quantitation by continuous-flow analysis (CFA) may be performed to assess severity of maternal immunization. Only five studies have reported its added value in the management of pregnancies complicated by anti-D immunization. A retrospective study of 74 severe anti-D-immunized pregnancies was conducted from January 1, 2013, to December 31, 2014, in the Trousseau Hospital in Paris (France). Concentration of maternal anti-D was measured by titration and by CFA two-stages method (2SM; total amount of anti-D) and one-stage method (1SM; high-affinity IgG1 anti-D). These biologic data were analyzed according to the severity of the hemolytic disease of the fetus and the newborn. The value of 5 IU anti-D/mL in maternal serum is validated as a threshold to trigger ultrasonographic and Doppler fetal close follow-up. A high 1SM/2SM ratio was associated with a higher risk of intrauterine transfusion (IUT). For pregnancies requiring IUT and without increasing titer, maternal 1SM anti-D concentration tends to correlate with the precocity of fetal anemia. In the "without-IUT" group 1SM and 2SM anti-D concentrations correlate significantly with cord bilirubin levels of the newborn at birth. Altogether our results underline the importance of anti-D quantitation by CFA to optimize the management of anti-D-alloimmunized pregnancies. © 2017 AABB.

Multimedia Interactive eBooks in Laboratory Bioscience Education

Science.gov (United States)

Morris, Neil P.; Lambe, James

2017-01-01

Bioscience students in the UK higher education system are making increasing use of technology to support their learning within taught classes and during private study. This experimental study was designed to assess the role for multimedia interactive eBooks in bioscience laboratory classes, delivered using a blended learning approach. Thirty-nine…

Rhesus anti-D immunoglobulin in chronic autoimmune neuropathy

NARCIS (Netherlands)

de Jager, AEJ; van der Hoeven, JH

Objective - To investigate the effect of Rhesus anti-D immunoglobulin (anti-D) in patients with an autoimmune demyelinating neuropathy. Material and methods - Three patients with an autoimmune mediated neuropathy received 1000 IU anti-D weekly for 2 months. Results - Two patients worsened gradually

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.

NARCIS (Netherlands)

Kapur, R.; Della Valle, L.; Verhagen, O.J.; Hipgrave Ederveen, A.; Ligthart, P.; de Haas, M.; Kumpel, B.; Wuhrer, M.; van der Schoot, C.E.; Vidarsson, G.

2015-01-01

Background RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III. Levels of immunoglobulin (Ig)G Fc-fucosylation influence interactions

Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D

NARCIS (Netherlands)

Kapur, Rick; Della Valle, Luciana; Verhagen, Onno J. H. M.; Hipgrave Ederveen, Agnes; Ligthart, Peter; de Haas, Masja; Kumpel, Belinda; Wuhrer, Manfred; van der Schoot, C. Ellen; Vidarsson, Gestur

2015-01-01

RhIG is obtained from hyperimmunized healthy anti-D donors (HIDs) boosted with D+ red blood cells (RBCs). One hypothesis for its mechanism of action is fast clearance of opsonized D+ RBCs through Fcγ receptor (FcγR)III. Levels of immunoglobulin (Ig)G Fc-fucosylation influence interactions with

Journal of Biosciences

Indian Academy of Sciences (India)

Madhu

The Journal of Biosciences welcomes contributions containing the results of original research in any area of biology. Both brief communications (within 4 typed pages or 1500 words of text) and full-length articles are accepted. There are no page charges for printing colour photographs. Fifty reprints will be supplied free of ...

Transient hemolysis due to anti-D and anti-A1 produced by engrafted donor's lymphocytes after allogeneic unmanipulated haploidentical hematopoietic stem cell transplantation.

Science.gov (United States)

Bailén, Rebeca; Kwon, Mi; Pérez-Corral, Ana María; Pascual, Cristina; Buño, Ismael; Balsalobre, Pascual; Serrano, David; Gayoso, Jorge; Díez-Martín, José Luis; Anguita, Javier

2017-10-01

Development of de novo alloantibodies against recipient's red blood cell (RBC) antigens by engrafted donor's lymphocytes is a known phenomenon in the setting of allogeneic hematopoietic stem cell transplantation (HSCT). This situation is usually clinically insignificant. We report a case of early clinically relevant hemolytic anemia in a blood group A 1 D+ patient, due to a limited production of anti-D and anti-A 1 produced by nonpreviously sensitized newly engrafted donor's immune system. A 31-year-old Caucasian woman, blood group A 1 , D+, with Hodgkin's lymphoma, received an unmanipulated haploidentical allogeneic peripheral blood HSCT after a nonmyeloablative conditioning regimen. Donor blood group was A 2 B, D-. The patient had an uneventful course until Day +34, when she developed clinically significant hemolytic anemia with a positive direct antiglobulin test. Anti-D and anti-A 1 produced by the donor-engrafted lymphocytes were detected both in serum and in eluate. The hemolysis produced an accelerated group change, turning the patient's ABO group into A 2 B 2 weeks after the detection of the alloantibodies. As the residual patient's RBCs progressively disappeared, anti-D and anti-A 1 production decreased and were not detected in serum by Day +41. This case illustrates that de novo alloantibody production against ABO and D antigens by the newly engrafted donor's lymphocytes can occasionally cause clinically significant anemia. To our knowledge, this is the first case reported of clinically significant hemolytic anemia due to a transient anti-D anti-A 1 alloimmunization after T-cell-repleted haploidentical HSCT. © 2017 AABB.

D-brane anti-D-brane system in string theory

CERN Document Server

Hyakutake, Y

2003-01-01

In this paper, we review a system of D-brane and anti-D-brane in type II superstring theories. [A. Sen, hep-th/9904207 and references there in; Y.Hyakutake, Master-Th., Doctor-Th. (in Japanese)] This system is unstable an tachyonic modes, which have negative mass squared, appear from open strings between D-brane and anti-D-brane. The effective field theory on the world-volume is described by U(1) x U(1) gauge theory with a complex tachyon field. Since the mass squared of the techyon field is negative, a tachyon potential would be like a wine bottle. In order to make the system stable, the tachyon rolls down the potential and gets some vacuum expectation value. This is called the tachyon condensation mechanism. During this mechanism, Dp-brane and anti-Dp-brane annihilate completely, if we admit Sen's conjecture. The suspicions between tachyon condensation and Hawking radiation are also discussed. (author)

Journal of Applied Biosciences

African Journals Online (AJOL)

The Journal of Applied Biosciences provides a forum for scholars and practitioners in all spheres of biological sciences to publish their research findings or theoretical concepts and ideas of a scientific nature. Other websites related to this journal: http://m.elewa.org/Journals/about-jab/ ...

Facilitators and barriers for RhD-immunized women to become and remain anti-D donors.

Science.gov (United States)

Slootweg, Yolentha Maria; Koelewijn, Johanna Maria; de Kort, Wim L; de Haas, Masja; Merz, Eva-Maria

2018-04-01

The successful introduction of prophylaxis with anti-RhD immunoglobulin has resulted in a significant decline of pregnancy-related RhD immunizations but also has decreased the availability of naturally immunized women as (new) anti-D donors. An influx of new donors is necessary to maintain a sufficient pool of anti-D donors. We investigated motivators, barriers, and predictors for anti-D donorship in RhD-immunized women. A mixed-methods design was applied, including focus group discussions and questionnaires. Two focus groups (including 11 women) served as input for the questionnaire. In total, 47.6% of 750 anti-D donors and potential donors completed the questionnaire (50.4% donors; 38% nondonors; 11.6% former donors). Almost 70% of the nondonors would have become donors if they had known about the possibility. Travel time investment was reported as a disadvantage; one-half of donors mentioned no disadvantages. Motivators for anti-D donorship were "doing something in return" (31.2%) and "preventing others having a sick child or losing a child" (33.9%). In multivariable analysis, living single (odds ratio, 5.8; p = 0.02) and living partnered without resident children (odds ratio, 7.9; p = 0.03), compared with living partnered with children, were predictors for anti-D donorship. Not being registered as an organ donor (odds ratio, 0.25; p anti-D donor. The main barrier for anti-D donorship was a lack of knowledge. Positive predictors of anti-D donorship were living without resident children, altruism, and being registered as an organ donor. A blood bank should develop targeted recruitment strategies with a focus on spreading knowledge about anti-D donorship among RhD-immunized women. © 2018 AABB.

New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity.

Science.gov (United States)

Romanucci, Valeria; Zarrelli, Armando; Liekens, Sandra; Noppen, Sam; Pannecouque, Christophe; Di Fabio, Giovanni

2018-02-10

The biological relevance of tetramolecular G-quadruplexes especially as anti-HIV agents has been extensively reported in the literature over the last years. In the light of our recent results regarding the slow G-quadruplex folding kinetics of ODNs based on d(TGGGAG) sequence, here we report a systematic anti-HIV screening to investigate the impact of the G-quadruplex folding on their anti-HIV activity. In particular, varying the single stranded concentrations of ODNs, it has been tested a pool of ODN sample solutions with different G-quadruplex concentrations. The anti-HIV assays have been designed favouring the limited kinetics involved in the tetramolecular G4-association based on the d(TGGGAG) sequence. Aiming to determine the stoichiometry of G-quadruplex structures in the same experimental conditions of the anti-HIV assays, a native gel electrophoresis was performed. The gel confirmed the G-quadruplex formation for almost all sample solutions while showing the formation of high order G4 structures for the more concentrated ODNs solutions. The most significant result is the discovery of a potent anti-HIV activity of the G-quadruplex formed by the natural d(TGGGAG) sequence (IC 50  = 14 nM) that, until now, has been reported to be completely inactive against HIV infection. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Risk factors for RhD immunisation despite antenatal and postnatal anti-D prophylaxis

NARCIS (Netherlands)

Koelewijn, J. M.; de Haas, M.; Vrijkotte, T. G. M.; van der Schoot, C. E.; Bonsel, G. J.

2009-01-01

Objective To identify risk factors for Rhesus D (RhD) immunisation in pregnancy, despite adequate antenatal and postnatal anti-D prophylaxis in the previous pregnancy. To generate evidence for improved primary prevention by extra administration of anti-D Ig in the presence of a risk factor. Design

Anti-D administration in pregnancy for preventing Rhesus alloimmunisation.

Science.gov (United States)

McBain, Rosemary D; Crowther, Caroline A; Middleton, Philippa

2015-09-03

During pregnancy, a Rhesus negative (Rh-negative) woman may develop antibodies when her fetus is Rhesus positive (Rh-positive). These antibodies may harm Rh-positive babies. To assess the effects of antenatal anti-D immunoglobulin on the incidence of Rhesus D alloimmunisation when given to Rh-negative women without anti-D antibodies. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (31 May 2015) and reference lists of retrieved studies. Randomised trials in Rh-negative women without anti-D antibodies given anti-D after 28 weeks of pregnancy, compared with no treatment, placebo or a different regimen of anti-D. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We included two trials involving over 4500 women, comparing anti-D prophylaxis with no anti-D during pregnancy in this review. Overall, the trials were judged to be at moderate to high risk of bias. The quality of the evidence for pre-specified outcomes was also assessed using the GRADE (Grades of Recommendation, Assessment, Development and Evaluation) approach.In regards to primary review outcomes, there did not appear to be a clear difference in the risks of immunisation when women who received anti-D at 28 and 34 weeks' gestation were compared with women who were not given antenatal anti-D: risk ratio (RR) for incidence of Rhesus D alloimmunisation during pregnancy was 0.42 (95% confidence interval (CI) 0.15 to 1.17, two trials, 3902 women; GRADE: low quality evidence); at birth of a Rh-positive infant the RR was 0.42 (95% CI 0.15 to 1.17, two trials, 2297 women); and within 12 months after birth of a Rh-positive infant the average RR was 0.39 (95% CI 0.10 to 1.62, two trials, 2048 women; Tau²: 0.47; I²: 39%; GRADE: low quality evidence). Neither of the trials reported on incidence of Rhesus D alloimmunisation in subsequent pregnancies.Considering secondary outcomes, in one trial, women receiving anti-D

Developing Research Capabilities in Energy Biosciences

Energy Technology Data Exchange (ETDEWEB)

Brown, Donald D.

2008-01-01

Scientists founded the Life Sciences Research Foundation (LSRF) in 1983 as a non-profit pass through foundation that awards post doctoral fellowships in all areas of the life sciences. LSRF scientists review hundreds of applications each year from PhDs seeking support. For example this year, our 26th, we received 800 applications and our peer review committee will choose about 50 finalists who are eligible for these awards. We have no endowment so we solicit sponsors each year. The fellowships are sponsored by research oriented companies, foundations, philanthropists, the Howard Hughes Medical Institute, and other organizations who believe in the value of awarding fellowships to the best and the brightest young scientists. Our web site has a complete listing of all details about LSRF (http://www.lsrf.org/). In the late 1980s the Division of Bioscience in the Office of Basic Energy Science, a granting agency of the Department of Energy, joined this partnership. Bioscience's mandate was to support non-medical microbiology and plant sciences. LSRF received a series of 5 year grants from DOE to award fellowships to our top applicants in these fields of research. We began to support DOE-Energy Bioscience post doctoral fellows in 1989. From 1989 through 2004 when DOE funding ended our partnership awarded 41 DOE-Energy Bioscience Fellows of the Life Sciences Research Foundation. Each of these was a three year fellowship. DOE-Energy Biosciences was well matched with LSRF. Our extensive peer review screened applicants in all areas of the life sciences. Most LSRF sponsors are interested in supporting fellows who work on diseases. At the time that we began our partnership with DOE we had no sponsors willing to support plant biology and non medical microbiology. For 15 years DOE played a major role in the training of the very best young scientists in these important fields of research simply through its support of LSRF post doctoral fellows. Young scientists interested in

Bioscience, bioinnovations, and bioethics.

Science.gov (United States)

Leisola, Matti

2007-01-01

Biosciences and their applications, which we call biotechnology, have affected human society in many ways. Great hopes have been set on future biotechnology. The future depends on three key issues. First, we need good science. Recent developments in biosciences have surprised us in many ways. I shall explain in this article how. Secondly, we need structured innovation systems in order to commercialize our discoveries. Europe is slow in this respect compared to our Japanese and American competitors and may lose in the competition. I shall describe the Finnish innovation chain using the rewarded Otaniemi model as an example of how commercialization can be done in a systematic way. Thirdly, we need norms to guide what to do and where to go. Bioethics is probably the most neglected of the three key issues. With modern biotechnology we are able to do things that should worry every citizen, but the ethical discussion has been largely neglected or the discussion in our pluralistic society is leading nowhere. I shall finally discuss these problems from a historical perspective.

Monitoring and treatment of anti-D in pregnancy

DEFF Research Database (Denmark)

Bettelheim, D; Panzer, S; Reesink, H W

2010-01-01

Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased...

Zc(3900)/Zc(3885) as a virtual state from πJ/ψ - anti D*D interaction

International Nuclear Information System (INIS)

He, Jun; Chen, Dian-Yong

2018-01-01

In this work, we study the πJ/ψ and anti D*D invariant mass spectra of the Y(4260) decay to find out the origin of the Z c (3900) and Z c (3885) structures. The πJ/ψ - anti D*D interaction is studied in a coupled-channel quasipotential Bethe-Saltpeter equation approach, and embedded to the Y(4260) decay process to reproduce both π - J/ψ and D *- D 0 invariant mass spectra observed at BESIII simultaneously. It is found out that a virtual state at energy about 3870 MeV is produced from the interaction when both invariant mass spectra are comparable with the experiment. The results support that both Z c (3900) and Z c (3885) have the same origin, that is, a virtual state from πJ/ψ - anti D*D interaction, in which the anti D*D interaction is more important and the coupling between anti D*D and πJ/ψ channels plays a minor role. (orig.)

Monitoring and treatment of anti-D in pregnancy

NARCIS (Netherlands)

Bettelheim, D.; Panzer, S.; Reesink, H. W.; Csapo, B.; Pessoa, C.; Guerra, F.; Wendel, S.; Calda, P.; Sprogøe, U.; Dziegiel, M.; Aitokallio-Tallberg, A.; Koskinen, S.; Kuosmanen, M.; Legler, T. J.; Stein, W.; Villa, S.; Villa, M. A.; Trespidi, L.; Acaia, B.; Vandenbussche, F. P. H. A.; Brand, A.; de Haas, M.; Kanhai, H. H. H.; Gounder, D.; Flanagan, P.; Donegan, R.; Parry, E.; Sefonte, C.; Skulstad, S. M.; Hervig, T.; Flesland, Ø; Zupańska, B.; Uhrynowska, M.; Lapaire, O.; Zhong, X. Y.; Holzgreve, W.

2010-01-01

Prophylactic anti-D is a very safe and effective therapy for the suppression of anti-D immunization and thus prevention of haemolytic disease of the foetus and newborn. However, migration from countries with low health standards and substantial cuts in public health expenses have increased the

Three methods to detect the predicted D anti D scalar meson X(3700)

International Nuclear Information System (INIS)

Xiao, C.W.; Oset, E.

2013-01-01

In analogy to the f 0 (500), which appears as a ππ resonance in chiral unitary theory, and the f 0 (980), which appears as a quasibound K anti K state, the extension of this approach to the charm sector also predicts a quasibound D anti D state with mass around 3720 MeV, named as X(3700), for which some experimental support is seen in the e + e - →J/ ψD anti D reaction close to the D anti D threshold. In the present work we propose three different experiments to observe it as a clear peak. The first one is the radiative decay of the ψ(3770), ψ(3770) → γX(3700) → γηη'. The second one proposes the analogous reaction ψ(4040) → γX(3700) → γηη' and the third reaction is the e + e- → J/ψX(3700) → J/ψηη'. Neat peaks are predicted for all the reactions and the calculated rates are found within measurable range in present facilities. (orig.)

Measurements of the absolute branching fractions for D→anti Kπe+νe, D→anti K*e+νe and determination of Γ(D+→anti K*0e+νe)/Γ(D+→anti K0e+νe)

International Nuclear Information System (INIS)

Ablikim, M.; Bai, J.Z.; Ban, Y.

2006-01-01

Using the data of about 33 pb -1 collected at and around 3.773 GeV with the BES-II detector at the BEPC collider, we have studied the exclusive semileptonic decays D + →K - π + e + ν e , D 0 →anti K 0 π - e + ν e , D + →anti K *0 e + ν e and D 0 →K *- e + ν e . The absolute branching fractions for the decays are measured to be BF(D + →K - π + e + ν e )=(3.50±0.75±0.27)%, BF(D 0 →anti K 0 π - e + ν e )=(2.61±1.04±0.28)%, BF(D + →anti K *0 e + ν e )=(5.06±1.21±0.40)% and BF(D 0 →K *- e + ν e )=(2.87±1.48±0.39)%. The ratio of the vector to pseudoscalar semileptonic decay rates Γ(D + →anti K *0 e + ν e )/Γ(D + →anti K 0 e + ν e ) is determined to be 0.57±0.17±0.02. (orig.)

Laboratory management of perinatal patients with apparently "new" anti-D.

Science.gov (United States)

Hannon, Judith L; Clarke, Gwen

2016-09-01

Despite the existence of long-standing, well-organized programs for Rh immune globulin (RhIG) prophylaxis, immune anti-D continues to be detected in the D– perinatal population. Between 2006 and 2008, 91 prenatal patients, found to have a previously unidentified anti-D, were followed up with a survey to their treating physician and with additional serologic testing where possible. The physician survey requested pregnancy and RhIG history information, including recent or distant potential alloimmunizing events, and the physicians were asked their opinion on the likely cause for the anti-D. Based on survey responses, updated RhIG information, and results of follow-up serology, anti-D was determined to be attributable to previously unreported RhIG in 44 of 91 (48.3%) cases and to active immunization (immune anti-D) in 36 of 91 cases (39.6%). A probable cause for alloimmunization was reported in 14 of 52 (26.9%) returned surveys. Anti-D alloimmunization continues to occur in our prenatal population despite a comprehensive approach to RhIG therapy. Observations from this prospective patient management strategy include the need for improved application of guidelines for RhIG administration and improved quality of information provided to laboratories assessing RhIG eligibility. A laboratory process for prospective follow-up when unexpected anti-D is detected in pregnancy is recommended.

Advanced NMR technology for bioscience and biotechnology

Energy Technology Data Exchange (ETDEWEB)

Hammel, P.C.; Hernandez, G.; Trewhella, J.; Unkefer, C.J. [Los Alamos National Lab., NM (US); Boumenthal, D.K. [Univ. of Utah, Salt Lake City, UT (US); Kennedy, M.A. [Pacific Northwest National Lab., Richland, WA (US); Moore, G.J. [Wayne State Univ., Detroit, MI (US)

1998-11-01

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). NMR plays critical roles in bioscience and biotechnology in both imaging and structure determination. NMR is limited, however, by the inherent low sensitivity of the NMR experiment and the demands for spectral resolution required to study biomolecules. The authors addressed both of these issues by working on the development of NMR force microscopy for molecular imaging, and high field NMR with isotope labeling to overcome limitations in the size of biomolecules that can be studied using NMR. A novel rf coil design for NMR force microscopy was developed that increases the limits of sensitivity in magnetic resonance detection for imaging, and the authors demonstrated sub-surface spatial imaging capabilities. The authors also made advances in the miniaturization of two critical NMR force microscope components. They completed high field NMR and isotope labeling studies of a muscle protein complex which is responsible for regulating muscle contraction and is too large for study using conventional NMR approaches.

Limited-sampling strategies for anti-infective agents: systematic review.

Science.gov (United States)

Sprague, Denise A; Ensom, Mary H H

2009-09-01

Area under the concentration-time curve (AUC) is a pharmacokinetic parameter that represents overall exposure to a drug. For selected anti-infective agents, pharmacokinetic-pharmacodynamic parameters, such as AUC/MIC (where MIC is the minimal inhibitory concentration), have been correlated with outcome in a few studies. A limited-sampling strategy may be used to estimate pharmacokinetic parameters such as AUC, without the frequent, costly, and inconvenient blood sampling that would be required to directly calculate the AUC. To discuss, by means of a systematic review, the strengths, limitations, and clinical implications of published studies involving a limited-sampling strategy for anti-infective agents and to propose improvements in methodology for future studies. The PubMed and EMBASE databases were searched using the terms "anti-infective agents", "limited sampling", "optimal sampling", "sparse sampling", "AUC monitoring", "abbreviated AUC", "abbreviated sampling", and "Bayesian". The reference lists of retrieved articles were searched manually. Included studies were classified according to modified criteria from the US Preventive Services Task Force. Twenty studies met the inclusion criteria. Six of the studies (involving didanosine, zidovudine, nevirapine, ciprofloxacin, efavirenz, and nelfinavir) were classified as providing level I evidence, 4 studies (involving vancomycin, didanosine, lamivudine, and lopinavir-ritonavir) provided level II-1 evidence, 2 studies (involving saquinavir and ceftazidime) provided level II-2 evidence, and 8 studies (involving ciprofloxacin, nelfinavir, vancomycin, ceftazidime, ganciclovir, pyrazinamide, meropenem, and alpha interferon) provided level III evidence. All of the studies providing level I evidence used prospectively collected data and proper validation procedures with separate, randomly selected index and validation groups. However, most of the included studies did not provide an adequate description of the methods or

anti p and anti d production in relativistic heavy ion collisions: Results of BNL-E858

Energy Technology Data Exchange (ETDEWEB)

Stankus, P; Nagamiya, S [Columbia Univ., Nevis Labs., Irvington, NY (United States); Aoki, M; Hayano, R S; Shimizu, Y [Tokyo Univ. (Japan); Beatty, J [Boston Univ., MA (United States); Beavis, D; Debbe, R [Brookhaven National Lab., Upton, NY (United States); Carroll, J B [California Univ., Los Angeles, CA (United States); Chiba, J; Tanaka, K H [National Lab. for High Energy Physics (KEK), Tsukuba (Japan); Doke, T; Kashiwagi, T; Kikuchi, J [Waseda Univ., Tokyo (Japan); Hallman, T J [Johns Hopkins Univ., Baltimore, MD (United States); Heckman, H H; Lindstrom, P J [Lawrence Berkeley Lab., CA (United States); Kirk, P N; Wang, Z F [Louisiana State Univ., Baton Rouge, LA (United States); Crawford, H J; Engelage, J; Greiner, L [Space Sciences Lab., California Univ., Berkeley, CA (United States); E858 Collaboration

1992-07-20

The production of long-lived negative secondaries, including [pi][sup -], K[sup -], antiprotons (anti p) and antideuterons (anti d) at 0deg in Si+Au, Si+Cu, and Si+Al collisions at the BNL-AGS has been measured using a double-bend, double-focussing spectrometer. The anti p rapidity spectra from all three targets are well fit by Gaussians centered (anti y = 1.7 - 1.8) at mid-rapidity, and are consistent with production in nucleon-nucleon first collisions. The anti d/anti p[sup 2] ratio in Si+Al collisions is lower by a factor of 10 than that seen in p+p and p+A collisions. (orig.).

Is LabTutor a helpful component of the blended learning approach to biosciences?

Science.gov (United States)

Swift, Amelia; Efstathiou, Nikolaos; Lameu, Paula

2016-09-01

To evaluate the use of LabTutor (a physiological data capture and e-learning package) in bioscience education for student nurses. Knowledge of biosciences is important for nurses the world over, who have to monitor and assess their patient's clinical condition, and interpret that information to determine the most appropriate course of action. Nursing students have long been known to find acquiring useable bioscience knowledge challenging. Blended learning strategies are common in bioscience teaching to address the difficulties students have. Student nurses have a preference for hands-on learning, small group sessions and are helped by close juxtaposition of theory and practice. An evaluation of a new teaching method using in-classroom voluntary questionnaire. A structured survey instrument including statements and visual analogue response format and open questions was given to students who participated in Labtutor sessions. The students provided feedback in about the equipment, the learning and the session itself. First year (n = 93) and third year (n = 36) students completed the evaluation forms. The majority of students were confident about the equipment and using it to learn although a few felt anxious about computer-based learning. They all found the equipment helpful as part of their bioscience education and they all enjoyed the sessions. This equipment provides a helpful way to encourage guided independent learning through practice and discovery and because each session is case study based and the relationship of the data to the patient is made clear. Our students helped to evaluate our initial use of LabTutor and found the sessions enjoyable and helpful. LabTutor provides an effective learning tool as part of a blended learning strategy for biosciences teaching. Improving bioscience knowledge will lead to a greater understanding of pathophysiology, treatments and interventions and monitoring. © 2016 John Wiley & Sons Ltd.

[Standardization of the quantitative flow cytometric test with anti-D antibodies for fetomaternal hemorrhage in RhD negative women].

Science.gov (United States)

Spychalska, Justyna; Uhrynowska, Małgorzata; Pyl, Hanna; Klimczak-Jajor, Edyta; Kopeć, Izabella; Peciakowska, Małgorzata; Gutowska, Renata; Gawlak, Maciej; Słomska, Sylwia; Dąbkowska, Syiwia; Szczecina, Roman; Dębska, Marzena; Brojer, Ewa

2015-07-01

In order to determine the appropriate dose of anti-D immunoglobulin to be administered as a preventive measure against hemolytic disease of the fetus/newborn in the subsequent pregnancy it is necessary to assess the number of fetal red blood cells that infiltrate/penetrate into the maternal circulation as a result of fetomaternal hemorrhage (FMH). One of the quantitative methods of FMH analysis is based on flow cytometry (FACS) which makes use of monoclonal antibodies to RhD antigen (anti-D test). The aim of the study was to further develop the method, evaluate its sensitivity and reproducibility and to compare it with the test based on the detection of fetal hemoglobin (HbF). The FACS study involved 20 RhD negative pregnant women and 80 RhD negative women after delivery. The following monoclonal antibodies were used: BRAD 3 FITC (anti-RhD antigen), CD45 PerCP (anti leukocyte antigen CD45), and anti-HbF PE. The fluorescence intensity of cells incubated with BRAD 3 FITC was demonstrated to depend on the RhD antigen expression, though the anti-D test also detects the weak D variant. The CD45 PerCP antibodies increased the sensitivity of anti-D test since they eliminated the leukocytes which non-specifically bind anti-D from the analysis. The presence of anti-D antibodies in maternal plasma does not affect the quantitative assessment of the fetal RhD positive fetal cells with BRAD 3 FITC. In case of FMH, the results of the anti-D test were similar to those with anti-HbF antibodies. The flow cytometric test with anti-D and anti-CD45 is useful in the assessment of the fetomaternal hemorrhage in RhD negative women. The sensitivity of the test is estimated at 0.05%.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Role of sound stimulation in reprogramming brain connectivity. Sraboni Chaudhury Tapas C Nag Suman Jain Shashi Wadhwa ... Keywords. Auditory pathway; avian; brain; sound stimulation; synaptic plasticity ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster ... operate in neural stem cells during normal brain development and during abnormal brain tumorigenesis. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 2 ... Department of Horticulture, Agriculture Faculty, Ilam University, Ilam, Iran; Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, New ...

Intramuscular anti-D in chronic immune thrombocytopenia children with severe thrombocytopenia.

Science.gov (United States)

Sirachainan, Nongnuch; Anurathapan, Usanarat; Chuansumrit, Ampaiwan; Songdej, Duantida; Wongwerawattanakoon, Pakawan; Hutspardol, Sakara; Kitpoka, Pimpun

2013-12-01

Nine patients with chronic immune thrombocytopenia and platelet counts anti-D. Phase 1 was anti-D daily for 5 days, followed by phase 2, anti-D weekly for 12 weeks and withheld when platelet counts ≥ 20 × 10(9) /L, and then phase 3 was anti-D once every 2 weeks for 24 weeks. According to the International Working Group criteria, in phase 1, 66.7% of patients responded to the treatment. In phases 2 and 3, 11.1% (0-41.7%) and 7.7% (0-33.3%) of total episodes of follow up, respectively, responded to the treatment. Therefore, intramuscular anti-D given at a dose of 10 mcg/kg for 5 days is an alternative method to raise platelet counts in chronic immune thrombocytopenia children with severe thrombocytopenia where the intravenous form of anti-D is not available. © 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Brain; differential proteomics; ICAT; LCM; neuron; tandem mass spectrometry ... but also for gaining valuable understanding into brain function and deciphering proteomics from the workbench to the bedside. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 5 ... Department of Physiology, Kangwon National University School of Medicine, Chuncheon ... Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, Republic ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 1 ... and Plant Breeding, University of Agricultural Sciences, Bangalore 560 065, India; Biometrics and Bioinformatics Unit, International Rice Research Institute, Los Banos, Philippines ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 30; Issue 2 ... From about 6000 brain sub-oesophageal ganglion complexes, the neuropeptide was isolated; and purified ... Radiochemical bioassay confirmed the pheromonotropic effect of the ...

An investigation of secondary anti-D immunisation among phenotypically RhD-negative individuals in the Chinese population.

Science.gov (United States)

Wang, Qing-Ping; Dong, Guang-Tao; Wang, Xue-Dong; Gu, Juan; Li, Zheng; Sun, An-Yuan; Shao, Chao-Peng; Pan, Zhao-Lin; Huang, Li-Hua; Xie, Wei-Xing; Sun, Guang-Ming; Chen, Jian-Jiang; Pei, Hao; Yang, Xiao-Juan; Shan, Ping-Nan

2014-04-01

Despite the introduction of anti-D prophylaxis into clinical practice, RhD alloimmunisation remains a problem, particularly in the context of transfusions and pregnancy-induced alloimmunisation. The incidence of RhD alloimmunisation among phenotypically RhD-negative individuals is unknown in most countries. We investigated RhD alloimmmunisation in RhD-negative pregnant women and transfusion recipients in south-east China in order to optimise the prevention of this phenomenon. We analysed the RhD alloimmunisation status of RhD-negative pregnant women and transfusion recipients in south-east China. The RhD blood types of the study population were identified by standard serological methods. The D antigen was further tested with the indirect antiglobulin test to exclude or confirm weak D or partial D types. RhC, c, E and e antigens were typed in all subjects. If anti-D antibody screening was positive, the specificity and titre of the antibody were determined. The Del phenotype was investigated by the polymerase chain reaction sequence-specific primer method. An anti-D antibody was found in 61 of 416 RhD-negative pregnant women (14.66%), and in 11 of 227 RhD-negative transfusion recipients (4.85%). None of the 72 RhD-negative pregnant women or transfusion recipients with anti-D had the Del phenotype. Anti-D antibodies were not detected among Del phenotype individuals and Del phenotypes were not found in anti-D antibody producing individuals. Our study suggests that the risk of alloimmunity-induced neonatal haemolysis increases in true RhD-negative multipara. Perinatal protection would be necessary in these patients, while antenatal anti-D testing and Rh immune globulin prophylaxis would be unnecessary for RhDel pregnant women. Pregnant women and transfusion recipients with the Del type seldom produce anti-D antibody. RhD-negative recipients are not at risk of alloimmunisation after transfusion with Del red blood cells.

Anti-3D Weapon Model Detection for Safe 3D Printing Based on Convolutional Neural Networks and D2 Shape Distribution

Directory of Open Access Journals (Sweden)

Giao N. Pham

2018-03-01

Full Text Available With the development of 3D printing, weapons are easily printed without any restriction from the production managers. Therefore, anti-3D weapon model detection is necessary issue in safe 3D printing to prevent the printing of 3D weapon models. In this paper, we would like to propose an anti-3D weapon model detection algorithm to prevent the printing of anti-3D weapon models for safe 3D printing based on the D2 shape distribution and an improved convolutional neural networks (CNNs. The purpose of the proposed algorithm is to detect anti-3D weapon models when they are used in 3D printing. The D2 shape distribution is computed from random points on the surface of a 3D weapon model and their geometric features in order to construct a D2 vector. The D2 vector is then trained by improved CNNs. The CNNs are used to detect anti-3D weapon models for safe 3D printing by training D2 vectors which have been constructed from the D2 shape distribution of 3D weapon models. Experiments with 3D weapon models proved that the D2 shape distribution of 3D weapon models in the same class is the same. Training and testing results also verified that the accuracy of the proposed algorithm is higher than the conventional works. The proposed algorithm is applied in a small application, and it could detect anti-3D weapon models for safe 3D printing.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay. NATALYA P ... Abstract. The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 39; Issue 3 ... International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru 502 ... Punjab Agricultural University, Ludhiana 141 027, India; RAK College of Agriculture, ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 35; Issue 1 ... profiling combined with physiological analysis at two time points for soybean seedlings in ... waterlogging through the management of carbohydrate consumption and by regulating ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 33; Issue 1. A songbird forebrain area potentially involved in auditory discrimination and memory formation ... a set of interconnected ascending and descending auditory brain pathways that ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 40; Issue 2 ... whole animal was studied after adaptation to low and high concentrations of riboflavin. ... India; Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj ...

Polarized antiquark flavor asymmetry DELTA anti u(x)-DELTA anti d(x) and the pion cloud

CERN Document Server

Fries, R J; Weiss, C

2003-01-01

The flavor asymmetry of the unpolarized antiquark distributions in the proton, anti u(x)- anti d(x)0. Using a simple chiral linear sigma model as an example, we demonstrate that in the meson cloud picture a large positive DELTA anti u(x)-DELTA anti d(x) can be obtained from pi-sigma interference contributions. This calls into question previous estimates based on rho-meson contributions alone, and indicates how the results of the meson cloud picture may be reconciled with those of quark-based models. (orig.)

Direct production of anti D0 mesons in neutrino-nucleon collisions

International Nuclear Information System (INIS)

Onipchuk, A.B.; Choban, E.A.

1992-01-01

The inclusive production of anti D 0 mesons in neutrino-nucleon collisions is studied from the viewpoint of the quasiparton mechanism. The ratio R anti D 0 υ = σ(υ μ N → μ - X)/σ(υ μ N → μ - X), the kinematic distributions averaged over the υ μ spectrum, and the average kinematic characteristics of the final μ - and anti D 0 mesons are calculated. The number of events with anti D 0 -meson production is estimated as a function of the number of inclusive events

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Apoptosis; bee; brain; cell division; nervous system ... have a distinct morphology, physiology and behaviour that correlate with their roles in the society and are characterized by some brain polymorphisms. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

In the same brain areas, VBM results also showed reduced grey and white matter volumes. ... alterations and disturbed functional brain activation during empathy task in persons affected with schizophrenia. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 28; Issue 4 ... of stochastic differential equation; spectral density; Tchebycheff's inequality ... Estimation of maximum harvesting effort has a great impact on the economics of fisheries and other ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 32; Issue 2 ... School of Life Sciences, Morgan-Tan International Center for Life Sciences, Fudan University, ... of China; Plant Biotechnology Research Center, School of Agriculture and Biology, ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential ... a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains ... determined in different fractions of whole brain after 21 days of treatment. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 38; Issue 4 ... Department of Plant Physiology, UPSC, Umeå University, S-90187 Umea, Sweden; Ecologie ... Lyon, France; Faculty of Applied Sciences, Department of Botany, University of Sri ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-10-26

Oct 26, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 5 ... the Early Pleistocene of East Africa, Western Asia and Southeast Asia, thus indirectly ... Centre of Advanced Studies in Geology, Panjab University, Chandigarh ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-08-10

Aug 10, 2009 ... A ubiquitous cue eliciting these plastic phenotypic responses is ... Among the conclusions that emerge from this exploration is the perspective that the plant cell is phenotypically plastic. ... Journal of Biosciences | News ...

Object-oriented programming for the biosciences.

Science.gov (United States)

Wiechert, W; Joksch, B; Wittig, R; Hartbrich, A; Höner, T; Möllney, M

1995-10-01

The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 40; Issue 4 ... the clusters obtained by a clustering algorithm applied on cancer gene expression data. ... In this context, we have used biochemical pathways, -value statistics of GO attributes, ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

HPLC analysis reveals the presence of beta amyloid in the OVX and HCL mice brain. Congo red staining analysis revealed the extent of amyloid deposition in OVX and hypercholesterolemia mice brain. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 30; Issue 5 ... A genomic library was generated using HindIII and the positive clones were sequenced and ... People's Republic of China; School of Agricultural Science and Technology, Suzhou ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2011-08-07

Aug 7, 2011 ... Home; Journals; Journal of Biosciences; Volume 36; Issue 3 ... pathways in animal models of human disease and in patients to provide insights ... progression of metastasis, immune cell trafficking, stem cell therapy, transgenic ...

Analysis list: ph-d [Chip-atlas[Archive

Lifescience Database Archive (English)

Full Text Available ph-d Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/p...h-d.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/ph-d.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/ph-d.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/ph-d.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/ph-d.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Cell_line.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Embryo.gml ...

Observation of an event of pair photoproduction of charmed anti D0D0-mesons

International Nuclear Information System (INIS)

Adamovich, M.I.; Aleksandrov, Yu.A.; Bolta, J.M.; Bravo, L.; Cartacci, A.M.; Chernyavskii, M.M.; Conforto, B.; Conti, A.; Crosetti, G.; Dagliana, M.G.

1981-12-01

An event will be described which has been observed in an experiment on charmed particle production by labelled photons from the supersynchrotron of CERN. This event has been recorded simultaneously in nuclear photoemulsion and by the magnetic spectrometer Omega-prim. It has been interpreted as the first event of pair photoproduction of charmed neutral D 0 D 0 -mesons. For anti D 0 → K + π - π - π + , an intrinsic decay time of tau (anti D 0 ) = (0.14 +- 0.01) x 10 -13 sec has been obtained and for D 0 → anti K 0 tau - e + ν, two solutions have been obtained: tau 1 (D 0 ) = (3.4 +- 0.3) x 10 -13 sec and tau 2 (D 0 ) = (7.5 +- 0.3) x 10 -13 sec. (orig.)

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 34; Issue 1 ... an overview of the implications of such a phenomenon for basic and applied research. ... Department of Crop Biology, Section of Plant Physiology, University of Pisa, Pisa, Italy ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 2 ... The nucleus accumbens (NAc), a critical structure of the brain reward circuit, is implicated in ... Reduction in the conductance of KIR channels evokes facilitatory effects on EPSPs ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Information for Authors ... Submission of a manuscript will be held to imply that the work reported in it is original, that .... when essential should be numbered consecutively and typed on a separate sheet.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats ... whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2007-06-28

Jun 28, 2007 ... Home; Journals; Journal of Biosciences; Volume 32; Issue 5 ... These methods suffer from disadvantages such as the lack of availability of ... In this work, we have constructed a library of local conformation classes purely ...

Can serological methods help distinguish between prophylactic and alloimmune anti-D?

Science.gov (United States)

Irving, C; Crennan, M; Vanniasinkam, T

2017-10-01

Enzyme indirect antiglobulin test (EIAT) and polyethylene glycol IAT (PIAT) were evaluated for their potential use as tests to distinguish between prophylactic and alloimmune anti-D in plasma by comparing with a tube variation of the standard low ionic strength solution-IAT (LISS-IAT). Laboratories performing the screening of RhD-negative pregnant women are required to provide clinicians with guidance as to the source of detected RhD antibodies. Currently, this is derived from RhIg immunoprophylaxis history, agglutination scores and titration results, where performed. A serological test that can differentiate between prophylactic and alloimmune anti-D would be useful in the diagnosis of RhD alloimmunisation in pregnant women. Plasma samples (n = 273) [fresh (collected from April 2014 to February 2015) and frozen (up to 2 years)] from antenatal females, preoperative males and females over child-bearing age were used in this study. Samples were identified as containing anti-D by routine column agglutination (CAT) and were tested by tube LISS-IAT, EIAT and PIAT, and a score difference was calculated. A total of 32% of alloimmune anti-D samples demonstrated an increase in agglutination score (+2 or +3) when tested by EIAT. A significant increase in agglutination score for alloimmune samples using EIAT compared with LISS-IAT was observed. EIAT had a sensitivity (Sn) of 59%, positive predictive value (PPV) of 100% and specificity (Sp) of 100% for alloimmune anti-D. EIAT is capable of confirming but not excluding the presence of alloimmune anti-D in samples where anti-D is detected in routine antibody screening. © 2017 British Blood Transfusion Society.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Zinc finger protein 521 is highly expressed in brain, neural stem cells and early ... Fndc5, a precursor of Irisin has inducing effects on the expression level of brain derived neurotrophic factor in hippocampus. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 34; Issue 6 ... of R. solani (35 colony-forming units/g dry soil) was relatively high in the soil we studied, and ... School of Environment, Resources and Development, Asian Institute of Technology, ...

Low serum vitamin D levels and anti-N-methyl-d-aspartate receptor encephalitis: A case-control study.

Science.gov (United States)

Shu, Yaqing; Su, Qingmei; Liao, Siyuan; Lu, Tingting; Li, Rui; Sun, Xiaobo; Qiu, Wei; Yang, Yu; Hu, Xueqiang; Lu, Zhengqi

2017-01-01

Low vitamin D levels are associated with autoimmunity, but the relationship with anti-N-Methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown. 25(OH) D levels and clinical and cerebrospinal fluid parameters were evaluated in 30 patients with anti-NMDAR encephalitis and compared with 90 age-, sex-, and season-matched healthy controls. 25(OH)D levels were lower in patients with anti-NMDAR encephalitis compared to controls (43.89 ± 17.91 vs 64.24 ± 24.38 nmol/L, p  30 years, p = 0.002), severe impairment (mRS ≥ 5) (vs mRS D levels were associated with age (r = 0.393, p = 0.032), and mRS (r = -0.417, p = 0.022). Our data showed that serum 25(OH)D levels were reduced in patients with anti-NMDAR encephalitis. Copyright © 2016. Published by Elsevier Ltd.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 41; Issue 2. Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring. Mohamed ... Keywords. Prenatal stress; Anxiety-like behavior; Memory performance; Hematological analysis; Periadolescence; Quercetin ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 43; Issue 2 ... The ErbB signalling pathway has been studied extensively owing to its role in normal physiology ... When applied to drug studies, the efficacy of a drug can be investigated in silico ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2008-10-15

Oct 15, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 4. Combating emerging infectious diseases in India: Orchestrating a symphony. Lalit Kant. Volume 33 Issue 4 November 2008 pp 425-427. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Here two very different kinds of organisms are considered: the volvocine algae that become ... that there is a perfect correlation with size: the forms with two cell types are significantly larger than those with one. ... Journal of Biosciences | News ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-12-09

Dec 9, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 6 ... and suitable teaching methods have been of great importance in the progress of knowledge. ... And what is valid for the learning of anatomy can be generalized to ...

Plasma homovanillic acid, plasma anti-D1 and -D2 dopamine-receptor activity, and negative symptoms in chronically mediated schizophrenia.

Science.gov (United States)

Suzuki, E; Kanba, S; Nibuya, M; Koshikawa, H; Nakaki, T; Yagi, G

1992-02-15

We have investigated the relationship between the concentration of homovanillic acid in human plasma (pHVA) and plasma anti-D1 and anti-D2 dopamine receptor activity in chronic schizophrenic patients whose neuroleptic dosage was changed. The change in pHVA level correlated with that in anti-D1, not anti-D2 activity, thus suggesting that the neuroleptic-induced changes in pHVA concentration may be associated with the blocking of D1- as well as D2- receptors. The change of scores on the Scale for the Assessment of Negative Symptoms did not significantly correlate with changes in anti-D1 or anti-D2 activity, but did so correlated with the change in pHVA level.

Chiral dynamics and the reactions pp→dK+ anti K0 and pp→dπ+η

International Nuclear Information System (INIS)

Oset, E.; Oller, J.A.; Meissner, U.G.

2001-01-01

We perform a study of the final-state interactions of the K + anti K 0 and the anti K 0 d systems in the reactions pp→dK + anti K 0 and pp→dπ + η. Since the two-meson system couples strongly to the a 0 (980) resonance, these reactions are expected to be an additional source of information about the controversial scalar sector. We also show that these reactions present peculiar features which can shed additional light on the much debated meson-baryon scalar sector with strangeness -1. We deduce the general structure of the amplitudes close to the dK + anti K 0 threshold, allowing for primary K + anti K 0 as well as π + η production with the two mesons in relative S- or P-wave. The interactions of the mesons are accounted for by using chiral unitary techniques, which generate dynamically the a 0 (980) resonance, and the anti K 0 d interaction is also taken into account. General formulae are derived that allow to incorporate the final-state interactions in these systems for any model of the production mechanism. We illustrate this approach by considering two specific production mechanisms based on three flavor meson-baryon chiral perturbation theory. It is demonstrated that in this scenario the anti K 0 d interactions are very important and can change the cross-section by as much as one order of magnitude. The amount of π + η versus K + anti K 0 production is shown to depend critically on the primary mixture of the two mechanisms, with large interference effects due to final-state interactions. These effects are also shown to occur in the event distributions of invariant masses which are drastically modified by the final-state interactions of the two-meson or the anti Kd system. (orig.)

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 41; Issue 2. Toward the 'new century' of handedness in biology: In commemoration of the 100th anniversary of the birth of Francis Crick. Koji Tamura. Clipboard Volume 41 Issue 2 June 2016 pp 169-170 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 40; Issue 5. Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus. Puli Chandramouli Reddy Ishani Sinha Ashwin Kelkar Farhat Habib Saurabh J Pradhan Raman Sukumar Sanjeev ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-09-04

Sep 4, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 4. Helicobacter urease: Niche construction at the single molecule level ... Departments of Lifesciences and # Computer Science, School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Punjab, Pakistan ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Logo of the Indian Academy of Sciences ... Home; Journals; Journal of Biosciences; Volume 28; Issue 1 ... Department of Safety and Environmental Management, College of Engineering and Mineral Resources, Morgantown, WV 26506, USA; Health Effects Laboratory Division, National Institute for Occupational Safety and ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 34; Issue 2 .... mapping, expression analysis and polymorphism survey of resistance gene analogues ... However, due to inconsistency in the results of empirical studies, the relationship between FA and ... MMP-1 polymorphism and its relationship to pathological processes.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 42; Issue 3 ... miR-200a-3p have been reported in the brains of Alzheimer'sdisease (AD) patients in recent researches. ... Knockdown of SIRT1 decreased theinhibitory effect of Ab25-35 on cell ...

Occurrence of anti-D alloantibodies among pregnant women in Kasese District, Western Uganda.

Science.gov (United States)

Mbalibulha, Yona; Muwanguzi, Enoch; Mugyenyi, Godfrey R; Natukunda, Bernard

2015-01-01

This study was undertaken to determine the distribution of ABO/RhD (rhesus D antigen) blood phenotypes, prevalence of anti-D alloantibodies, and the risk factors for alloimmunization among pregnant women in Kasese District, Western Uganda. Ethylenediamine tetraacetic acid-containing plasma samples and serum samples were taken from pregnant women attending the antenatal clinic. The blood groups were identified using the microplate grouping method, while the presence of anti-D alloantibodies was detected by the indirect antiglobulin test (IAT). Data were also collected from the pregnant women on the risk factors associated with anti-D alloantibody formation. Among the 726 participants, the blood group distribution was as follows: O: 356 (49.%); A: 190 (26.%); B: 152 (21%); and AB: 28 (4%). A total of 28 (3.86%) pregnant women were RhD negative. Anti-D alloantibodies were detected in 88 (12.1%) of the participants; and of these, 13 (14.8%) were RhD negative. Statistically significant risk factors for anti-D alloimmunization included miscarriage, stillbirth, and postpartum hemorrhage. Blood group O was the most common among the pregnant women in this study and the prevalence of Rh negativity was 3.8%. The frequency of anti-D alloimmunization among pregnant women in Kasese District was 12.12%, with 85.5% of these being RhD positive. Risk factors such as a history of stillbirths, miscarriages, and incidence of postpartum hemorrhage were significantly associated with anti-D alloimmunization. There is a need to routinely carry out antenatal blood grouping and IAT screening on pregnant women in Uganda to detect anti-D alloimmunization. Given the high prevalence of anti-D alloantibody formation among RhD-positive women, we recommend additional research studies on the role of autoimmunity among antigen-positive women, as well as the occurrence of RhD variants plus their implications on hemolytic disease of the fetus and newborn, in Uganda.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-08-19

Aug 19, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 3. What history tells us XVIII. When functional biologists propose mechanisms of evolution. Michel Morange. Series Volume 34 Issue 3 September 2009 pp 373-376. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-02-24

Feb 24, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 1. Classical embryology to molecular biology: a personal view of amphibian embryonic development. Horst Grunz. Perspectives Volume 34 Issue 1 March 2009 pp 5-16. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 4. Eu-Detect: An algorithm for detecting eukaryotic sequences in metagenomic data sets. Monzoorul Haque Mohammed Sudha Chadaram Dinakar Dinakar Komanduri Tarini Shankar Ghosh Sharmila S Mande. Articles Volume 36 Issue 4 September 2011 pp 709- ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 42; Issue 1. Overexpression of hsa-miR-939 follows by NGFR down-regulation and apoptosis reduction. FAHIMEH HOSSEINI AGHDAEI BAHRAM M SOLTANI SADAT DOKANEHIIFARD SEYED JAVAD MOWLA MASOUD SOLEIMANI. Article Volume 42 Issue 1 March 2017 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2005-11-23

Nov 23, 2005 ... Home; Journals; Journal of Biosciences; Volume 30; Issue 5. Commentary: Neuronal survival in epilepsy: to die or not to die? Subramaniam Ganesh Shweta Singh. Volume 30 Issue 5 December 2005 pp 561-566. Fulltext. Click here to view fulltext PDF. Permanent link:

Occurrence of anti-D alloantibodies among pregnant women in Kasese District, Western Uganda

Directory of Open Access Journals (Sweden)

Mbalibulha Y

2015-04-01

Full Text Available Yona Mbalibulha,1 Enoch Muwanguzi,1 Godfrey R Mugyenyi,2 Bernard Natukunda1 1Department of Medical Laboratory Sciences, 2Department of Obstetrics and Gynecology, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda Objectives: This study was undertaken to determine the distribution of ABO/RhD (rhesus D antigen blood phenotypes, prevalence of anti-D alloantibodies, and the risk factors for alloimmunization among pregnant women in Kasese District, Western Uganda. Materials and methods: Ethylenediamine tetraacetic acid-containing plasma samples and serum samples were taken from pregnant women attending the antenatal clinic. The blood groups were identified using the microplate grouping method, while the presence of anti-D alloantibodies was detected by the indirect antiglobulin test (IAT. Data were also collected from the pregnant women on the risk factors associated with anti-D alloantibody formation. Results: Among the 726 participants, the blood group distribution was as follows: O: 356 (49.%; A: 190 (26.%; B: 152 (21%; and AB: 28 (4%. A total of 28 (3.86% pregnant women were RhD negative. Anti-D alloantibodies were detected in 88 (12.1% of the participants; and of these, 13 (14.8% were RhD negative. Statistically significant risk factors for anti-D alloimmunization included miscarriage, stillbirth, and postpartum hemorrhage. Conclusion: Blood group O was the most common among the pregnant women in this study and the prevalence of Rh negativity was 3.8%. The frequency of anti-D alloimmunization among pregnant women in Kasese District was 12.12%, with 85.5% of these being RhD positive. Risk factors such as a history of stillbirths, miscarriages, and incidence of postpartum hemorrhage were significantly associated with anti-D alloimmunization. There is a need to routinely carry out antenatal blood grouping and IAT screening on pregnant women in Uganda to detect anti-D alloimmunization. Given the high prevalence of

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 37; Issue 4. Commentary: Monotremes and marsupials: Comparative models to better understand the function of milk. Sanjana Kuruppath Swathi Bisana Julie A Sharp Christophe Lefevre Satish Kumar Kevin R Nicholas. Volume 37 Issue 4 September 2012 pp 581-588 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2007-02-09

Feb 9, 2007 ... Home; Journals; Journal of Biosciences; Volume 32; Issue 2. What history tells us VIII. The progressive construction of a mechanism for prion diseases. Michel Morange. Series Volume 32 Issue 2 March 2007 pp 223-227. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 28; Issue 4. Hypervariable spacer regions are good sites for developing specific PCR-RFLP markers and PCR primers for screening actinorhizal symbionts. Rajani Varghese Vineeta S Chauhan Arvind K Misra. Articles Volume 28 Issue 4 June 2003 pp 437-442 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2008-12-09

Dec 9, 2008 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 4. Phenotypic plasticity ... Articles Volume 34 Issue 4 October 2009 pp 605-611 ... Stem cell immortality, vascular autonomy, and epicormic branching are some important features of the phenotypic plasticity of plants that contribute to their longevity.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2009-05-18

May 18, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 2. Clipboard: Snakes and ladders: the ups and downs of animal segmentation. Ramray Bhat Stuart A Newman. Volume 34 Issue 2 June 2009 pp 163-166. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Journals; Journal of Biosciences; Volume 35; Issue 1. Transgene transmission in South American catfish (Rhamdia quelen) larvae by sperm-mediated gene transfer. Tiago Collares Vinicius Farias Campos Fabiana Kömmling Seixas Paulo V Cavalcanti Odir A Dellagostin Heden Luiz M Moreira João Carlos Deschamps.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 33; Issue 1 ... In the present investigation, we evaluated the level of platelet aggregation and ... cirrhosis found in our study is of clinical importance, and the underlying mechanism of such ... Department of Surgical Gastroenterology and Proctology, Stanley Medical College ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Anandasankar Ray1 2 Wynand Van Der Goes Van Naters2 3 John R Carlson2. Department of Entomology, University of California, Riverside, CA 92521, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA; School of Biosciences, Cardiff University, Cardiff, UK ...

The challenge of the Biosciences in Nurse Education: A literature review.

Science.gov (United States)

Jensen, Kari Toverud; Knutstad, Unni; Fawcett, Tonks N

2018-03-25

To review relevant literature that address the challenges of the biosciences in nurse education. More precisely the review aims to explore the literature, concerning students' learning, learning contexts and methodological issues and identify any significant gaps. Knowledge of anatomy, physiology and biochemistry are essential for the understanding of human beings and for full appreciation of the concepts of illness and disease. The current status would seem to be that the required competencies within bioscience subjects are difficult to acquire and students have high rates of failure. Integrative review. The research were performed on Cinahl, ERIC, Medline and British Nursing Index databases in a period from 2013 until 2017. Descriptive analytical methods were used for the initial research trawl. The search strategy resulted in 23 papers. The results of this review shed light on certain deficiencies in the research field looking at the biosciences in nurse education. There is a distinct lack of intervention studies, and thereby knowledge of how best to support students' learning in effective ways. Of note is that there are no field study approaches identified in the review sample. Many of the papers are single studies and course evaluations which may be seen as too narrow and inadequate a perspective. Students appear satisfied with the courses in the biosciences but there seems to be no correlation between satisfaction and achievement. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 27; Issue 6. Issue front cover thumbnail. Volume 27, Issue 6. November 2002, pages 552-627. Special Issue on Suppl. 3: The Biology of Entamoeba histolytica. pp 552-552a. Preface · Anuradha Lohia · More Details Fulltext PDF. pp 553-557 Articles.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 40; Issue 3. A rapidly progressing, deadly disease of Actias selene (Indianmoonmoth) larvae associated with a mixed bacterial and baculoviral infection. Marta A Skowron Beata Guzow-Krzemińska Sylwia Barańska Paulina Jędrak Grzegorz Węgrzyn. Articles Volume 40 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 33; Issue 2. Issue front cover thumbnail. Volume 33, Issue 2. June 2008, pages 157-307. pp 157-158. Clipboard: Recovery from amblyopia in adults via decreased visual cortical inhibition caused by experience in an enriched environment · Liisa A Tremere Raphael Pinaud.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 34; Issue 2 ... Review Volume 34 Issue 2 June 2009 pp 313-320 ... Matrix metalloproteinases (MMPs) are a family of zinc (Zn)-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and play an important role in ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 27; Issue 4 ... areas, so the data used to make such comparisons should be comparable in quality and quantity. ... data include museums, herbariums and natural resource management agencies. Issues of data precision, accuracy and sampling bias in data sets from such ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 28; Issue 6. A skeletochronological study of growth, longevity, and age at sexual maturity in a population of Rana latastei (Amphibia, Anura). Fabio M Guarino Silvia Lunardi Michela Carlomagno Stefano Mazzotti. Articles Volume 28 Issue 6 December 2003 pp 775-782 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 5. Cytomixis impairs meiosis and influences reproductive success in Chlorophytum comosum (Thunb) Jacq. – an additional strategy and possible implications. S K Lattoo S Khan S Bamotra A K Dhar. Reviews Volume 31 Issue 5 December 2006 pp 629-637 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2005-11-15

Nov 15, 2005 ... Home; Journals; Journal of Biosciences; Volume 30; Issue 5. What history tells us III. André Lwoff: From protozoology to molecular definition of viruses. Michel Morange. Series Volume 30 Issue 5 December 2005 pp 591-594. Fulltext. Click here to view fulltext PDF. Permanent link:

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

... Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Biosciences; Volume 28; Issue 2. Integrative microbiology – the third Golden Age. Moselio Schaechter. Perspectives Volume 28 Issue 2 March 2003 pp 149-154 ...

On effects of D0-anti D0 mixing at SPEAR

International Nuclear Information System (INIS)

Kingsley, R.L.

1976-01-01

The channels in which D 0 -anti D 0 mixing effects might be observed at SPEAR are discussed. The general theoretical industry of the last two years on the properties of charmed particles has been crowned by the announcement of a candidate for the particle D 0 and its antiparticle in the decay D 0 →K - π + at SPEAR. Clearly, e + e - colliding beams are a prime laboratory for the study of the decays of these particles. (Auth.)

A production in anti p - d interactions below 1 GeV/c

International Nuclear Information System (INIS)

Smith, D.W.; Billiris, B.; Mandelkern, L.R.; Price, L.R.; Schultz, J.

1979-01-01

382 Λ events have been measured and analyzed in an anti p - d bubble chamber experiment at 552, 740, and 905 MeV/c. We compare our data with two other anti p - d experiments at beam momenta from 1 to 3 GeV/c. Some features of the double scattering mechanism are calculated using an anti K and anti Λ as the exchanged particles. The anti K exchange appears to be a more likely candidate for the production mechanism. (auth)

The zero mass limit of Kerr and Kerr-(anti-)de-Sitter space-times: exact solutions and wormholes

Science.gov (United States)

Birkandan, T.; Hortaçsu, M.

2018-03-01

Heun-type exact solutions emerge for both the radial and the angular equations for the case of a scalar particle coupled to the zero mass limit of both the Kerr and Kerr-(anti)de-Sitter spacetime. Since any type D metric has Heun-type solutions, it is interesting that this property is retained in the zero mass case. This work further refutes the claims that M going to zero limit of the Kerr metric is both locally and globally the same as the Minkowski metric.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 41; Issue 3 .... HUWE1 (the HECT, UBA, and WWE domain-containing protein 1) is an ubiquitin E3 ligase which plays .... pp 487-496 Review ... Galectin-9: From cell biology to complex disease dynamics ... Application of aptamers in diagnostics, drug-delivery and imaging.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 5. Combinative effects of a bacterial type-III effector and a biocontrol bacterium on rice growth and disease resistance. Haiying Ren Ganyu Gu Juying Long Qian Yin Tingquan Wu Tao Song Shujian Zhang Zhiyi Chen Hansong Dong. Reviews Volume 31 Issue 5 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2010-02-10

Feb 10, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 1. What history tells us XX. Felix Haurowitz (1896–1987) – A difficult journey in the political and scientific upheavals of the 20th century. Michel Morange. Series Volume 35 Issue 1 March 2010 pp 17-20 ...

Integrating anticipated nutrigenomics bioscience applications with ethical aspects

NARCIS (Netherlands)

Levesque, L.; Ozdemir, V.; Gremmen, B.; Godard, B.

2008-01-01

Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues

Discrete Torsion, (Anti) de Sitter D4-Brane and Tunneling

Science.gov (United States)

Singh, Abhishek K.; Pandey, P. K.; Singh, Sunita; Kar, Supriya

2014-06-01

We obtain quantum geometries on a vacuum created pair of a (DDbar)3-brane, at a Big Bang singularity, by a local two form on a D4-brane. In fact our analysis is provoked by an established phenomenon leading to a pair creation by a gauge field at a black hole horizon by Stephen Hawking in 1975. Importantly, the five dimensional microscopic black holes are described by an effective non-perturbative curvature underlying a discrete torsion in a second order formalism. In the case for a non-propagating torsion, the effective curvature reduces to Riemannian, which in a low energy limit may describe Einstein vacuum in the formalism. In particular, our analysis suggests that a non-trivial space begin with a hot de Sitter brane-Universe underlying a nucleation of a vacuum pair of (DDbar)-instanton at a Big Bang. A pair of instanton nucleats a D-particle which in turn combines with an anti D-particle to describe a D-string and so on. The nucleation of a pair of higher dimensional pair of brane/anti-brane from a lower dimensional pair may be viewed via an expansion of the brane-Universe upon time. It is in conformity with the conjecture of a branes within a brane presumably in presence of the non-zero modes of two form. Interestingly, we perform a thermal analysis underlying various emergent quantum de Sitter vacua on a D4-brane and argue for the plausible tunneling geometries underlying a thermal equilibrium. It is argued that a de Sitter Schwarzschild undergoes quantum tunneling to an AdS-brane Schwarzschild via Nariai and de Sitter topological black hole.

Discrete Torsion, (Anti) de Sitter D4-Brane and Tunneling

International Nuclear Information System (INIS)

Singh, Abhishek K.; Pandey, P.K.; Singh, Sunita; Kar, Supriya

2014-01-01

We obtain quantum geometries on a vacuum created pair of a (DD ¯ ) 3 -brane, at a Big Bang singularity, by a local two form on a D 4 -brane. In fact our analysis is provoked by an established phenomenon leading to a pair creation by a gauge field at a black hole horizon by Stephen Hawking in 1975. Importantly, the five dimensional microscopic black holes are described by an effective non-perturbative curvature underlying a discrete torsion in a second order formalism. In the case for a non-propagating torsion, the effective curvature reduces to Riemannian, which in a low energy limit may describe Einstein vacuum in the formalism. In particular, our analysis suggests that a non-trivial space begin with a hot de Sitter brane-Universe underlying a nucleation of a vacuum pair of (DD ¯ )-instanton at a Big Bang. A pair of instanton nucleats a D-particle which in turn combines with an anti D-particle to describe a D-string and so on. The nucleation of a pair of higher dimensional pair of brane/anti-brane from a lower dimensional pair may be viewed via an expansion of the brane-Universe upon time. It is in conformity with the conjecture of a branes within a brane presumably in presence of the non-zero modes of two form. Interestingly, we perform a thermal analysis underlying various emergent quantum de Sitter vacua on a D 4 -brane and argue for the plausible tunneling geometries underlying a thermal equilibrium. It is argued that a de Sitter Schwarzschild undergoes quantum tunneling to an AdS-brane Schwarzschild via Nariai and de Sitter topological black hole

Z{sub c}(3900)/Z{sub c}(3885) as a virtual state from πJ/ψ - anti D*D interaction

Energy Technology Data Exchange (ETDEWEB)

He, Jun [Nanjing Normal University, Department of Physics and Institute of Theoretical Physics, Nanjing (China); Chen, Dian-Yong [Southeast University, School of Physics, Nanjing (China)

2018-02-15

In this work, we study the πJ/ψ and anti D*D invariant mass spectra of the Y(4260) decay to find out the origin of the Z{sub c}(3900) and Z{sub c}(3885) structures. The πJ/ψ - anti D*D interaction is studied in a coupled-channel quasipotential Bethe-Saltpeter equation approach, and embedded to the Y(4260) decay process to reproduce both π{sup -}J/ψ and D{sup *-}D{sup 0} invariant mass spectra observed at BESIII simultaneously. It is found out that a virtual state at energy about 3870 MeV is produced from the interaction when both invariant mass spectra are comparable with the experiment. The results support that both Z{sub c}(3900) and Z{sub c}(3885) have the same origin, that is, a virtual state from πJ/ψ - anti D*D interaction, in which the anti D*D interaction is more important and the coupling between anti D*D and πJ/ψ channels plays a minor role. (orig.)

D-brane anti-brane annihilation in an expanding universe

International Nuclear Information System (INIS)

Majumdar, Mahbub; Davis, Anne-Christine

2003-01-01

The time-varying density of D-branes and anti-D-branes in an expanding universe is calculated. The D-brane anti-brane annihilation rate is shown to be too small to compete with the expansion rate of a FRW type universe and the branes over-close the universe. This brane problem is analogous to the old monopole problem. Interestingly however, it is shown that small dimension D-branes annihilate more slowly than high dimension branes. Hence, an initially brany universe may be filled with only low dimension branes at late times. When combined with an appropriate late inflationary theory this leads to an attractive dynamical way to create a realistic braneworld scenario. (author)

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Alok Bhattacharya1. School of Life Sciences and Information Technology, Jawaharlal Nehru University, New Delhi 110 007, India. Journal of Biosciences. Current Issue : Vol. 43, Issue 1 · Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 37; Issue 4. Changes in membrane lipids and carotenoids during light acclimation in a marine cyanobacterium Synechococcus sp. Olimpio Montero Alberto Sánchez-Guijo Luis M Lubián Gonzalo Martínez-Rodríguez. Articles Volume 37 Issue 4 September 2012 pp 635-645 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 27; Issue 1. Issue front cover thumbnail. Volume 27, Issue 1. February 2002, pages a-70. Genome Analysis. pp a-a. Preface · Alok Bhattacharya · More Details Fulltext PDF. pp 1-6. SWORDS: A statistical tool for analysing large DNA sequences · Probal Chaudhuri Sandip Das.

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences; Volume 34; Issue 6. Identification and ... Alignment and phylogenetic analysis indicated that GbAGL2 shared high homology with AG-subfamily genes and belonged to a C-class gene family. DNA gel blot analysis showed that GbAGL2 belonged to a low-copy gene family. Reverse ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 4. RET gene mutations and ... Articles Volume 36 Issue 4 September 2011 pp 603-611 ... Further, 39 family members of seven index cases were analysed, wherein four of the seven index cases showed identical mutations, in 13 of 25 family members. We also ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 42; Issue 1. Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. AAMIR ALI SHWETA TYAGI. Mini-Review Volume 42 Issue 1 ... Keywords. Cell cycle regulation; SET1 family; transcription; WRAD ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 40; Issue 5. Issue front cover thumbnail. Volume 40, Issue 5. December 2015, pages 829-968. pp 829-832 Series. What history tells us XXXIX. CRISPR-Cas : From a prokaryotic immune system to a universal genome editing tool · Michel Morange · More Details Fulltext PDF.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2011-03-14

Mar 14, 2011 ... Home; Journals; Journal of Biosciences; Volume 36; Issue 1. Clipboard: New paradigm for ATP synthesis and consumption. C Channakeshava. Volume 36 Issue 1 March 2011 pp 3-4. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/036/01/0003-0004 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, CP 354, 96010-900, Pelotas, RS, Brazil; Faculty of Biosciences and Aquaculture, Bodø University College, NO-8049 Bodø, Norway; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, CP 474, ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 26; Issue 2. The roots of ancient medicine: an historical outline. B V Subbarayappa. Perspectives Volume 26 Issue 2 June 2001 pp 135-143. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/026/02/0135-0143. Author Affiliations.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2006-05-06

May 6, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Kenneth Raper, Elisha Mitchell and Dictyostelium. Eugene R Katz. Perspectives Volume 31 Issue 2 June 2006 pp 195-200. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/031/02/0195-0200 ...

Consequences of R-parity violating interactions for anomalies in anti B → D(*)τ anti ν and b → sμ+μ-

International Nuclear Information System (INIS)

Deshpande, N.G.; He, Xiao-Gang

2017-01-01

We investigate the possibility of explaining the enhancement in semileptonic decays of anti B → D (*) τ anti ν, the anomalies induced by b → sμ + μ - in anti B → (K, K*, φ)μ + μ - and violation of lepton universality in R K = Br(anti B → Kμ + μ - )/Br(anti B → Ke + e - ) within the framework of R-parity violating MSSM. The exchange of down type right-handed squark coupled to quarks and leptons yields interactions which are similar to leptoquark induced interactions that have been proposed to explain the anti B → D (*) τ anti ν by tree level interactions and b → sμ + μ - anomalies by loop induced interactions, simultaneously. However, the Yukawa couplings in such theories have severe constraints from other rare processes in B and D decays. Although this interaction can provide a viable solution to the R(D (*) ) anomaly, we show that with the severe constraint from anti B → Kν anti ν, it is impossible to solve the anomalies in the b → sμ + μ - process simultaneously. (orig.)

Preparation of 99''m technitium labelled erythrocytes coated with anti-rhesus-D immunoglobulin (anti-Rho-D IgG) for defective spleen diagnosis

International Nuclear Information System (INIS)

Nanny Kartini, H.; Karnama, S.; Ahmad Muhtadi; Karna Awangga

1999-01-01

Preparation of 99m technetium-red blood cells coated with anti-rhesus-D IgG has been carried out and evaluated. Some factors such as the concentration of Sn(II) and incubation time which can influence the labelling yield are discussed. A labelling efficiency of greater than 90% (93.1 ±1.4% ) was obtained. Biological studies in normal human volunteers, showed that 99m Tc-red blood cell coated with anti-rhesus-D IgG accumulated in the spleen and may become a spleen imaging agent. (author)

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 28; Issue 3. Issue front cover thumbnail. Volume 28, Issue 3. April 2003, pages 248-358. Viral Evasion of Host Responses. pp 248-248. Preface · Shahid Jameel · More Details Fulltext PDF. pp 249-264 Articles. Viral mimicry of the complement system · John Bernet Jayati ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Issue front cover thumbnail. Volume 31, Issue 2. June 2006, pages 177-292. pp 177-179. Clipboard: Simple laboratory tests of ecological theories: what we can learn from them, and when we should be cautious · Mike S Fowler Lasse Ruokolainen · More Details ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Genetic transformation of peanut (Arachis hypogaea L.) using cotyledonary node as explant and a promoterless gus::nptII fusion gene based vector. T Swathi Anuradha S K Jami R S Datla P B Kirti. Articles Volume 31 Issue 2 June 2006 pp 235-246 ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences; Volume 32; Issue 4. Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. Kwang Sik Lee Bo Yeon Kim Yeon Ho Je Soo Dong Woo Hung Dae Sohn Byung Rae Jin. Articles Volume 32 Issue 4 June 2007 pp 705-712 ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 35; Issue 2. Issue front cover thumbnail. Volume 35, Issue 2. June 2010, pages 163-325. pp 163-165. Clipboard: Heat shock protein 90: a capacitor or a mutator? Ritwick Sawarkar Renato Paro · More Details Fulltext PDF. pp 167-169. Clipboard: The small subunit of geranyl ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2016-08-26

Aug 26, 2016 ... Home; Journals; Journal of Biosciences; Search ... part of the email address of all email addresses used by the office of Indian Academy of Sciences, including those of the staff, the journals, various programmes, and Current Science, has changed from 'ias.ernet.in' (or 'academy.ias.ernet.in') to 'ias.ac.in'.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 26; Issue 4. Is there a role for contraceptive vaccines in fertility control? A Jagannadha Rao. Volume 26 Issue 4 November 2001 pp 425-427. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/026/04/0425-0427. Keywords. Fertility ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 42; Issue 1. What history tells us XLII. A 'new' view of proteins. MICHEL MORANGE. Series Volume 42 Issue 1 March 2017 pp 11-14. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/042/01/0011-0014. Keywords. Allostery ...

Journal of Biosciences | Indian Academy of Sciences

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Home; Journals; Journal of Biosciences; Volume 26; Issue 4. Issue front cover thumbnail. Volume 26, Issue 4. November 2001, pages 390a-545. Population of India. pp 390a-390a. Preface · Partha P Majumder A Jagannadha Rao · More Details Fulltext PDF. pp 391-405. Current status of fertility control methods in India.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 29; Issue 1. What impact, if any, has feminism had on science? Evelyn Fox Keller. Perspectives Volume 29 Issue 1 March 2004 pp 7-13. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/029/01/0007-0013. Author Affiliations.

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 31; Issue 1. Issue front cover thumbnail. Volume 31, Issue 1. March 2006, pages 1-176e. pp 1-2. Clipboard: Ancient Indian roots? Denise R Carvalho-Silva Tatiana Zerjal Chris Tyler-Smith · More Details Fulltext PDF. pp 3-4. Commentary: Magic with moulds: Meiotic and ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2010-11-09

Nov 9, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 4. What history tells us XXII. The French neo-Lamarckians. Michel Morange. Series Volume 35 Issue 4 December 2010 pp 515-517. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/035/04/0515-0517 ...

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn: what can we learn from rodent models?

Science.gov (United States)

Brinc, Davor; Denomme, Gregory A; Lazarus, Alan H

2009-11-01

Hemolytic disease of the fetus and newborn can be effectively prevented by administration of anti-D to the mother. In this setting, the IgG purified from the plasma of D-alloimmunized donors prevents the maternal immune response to D-positive red blood cells (RBC). Several monoclonal anti-D antibodies have recently been developed for potential use in the setting of hemolytic disease of the fetus and newborn; the functional assays used to assess the potential success of these antibodies have often assumed antigen clearance as the predominant mechanism of anti-D. Unfortunately, the in-vivo success of these monoclonal antibodies has thus far been limited. A similar inhibitory effect of IgG has been observed in animal models with a vast array of different antigens, referred to as antibody-mediated immune suppression (AMIS). Here, studies of AMIS are reviewed and the relevance of these findings for anti-D-mediated immunoprophylaxis is discussed. In animal models of AMIS, IgG-mediated antigen clearance was not sufficient for prevention of the antibody response to RBC. Furthermore, anti-RBC IgG inhibited B-cell priming to foreign RBC, but failed to prevent a T-cell response and immunological memory. The applicability of AMIS models for determining the true mechanism of anti-D, though uncertain, may nevertheless provide knowledge as to potential mechanisms of action of anti-RBC antibodies.

75 FR 64733 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal

Science.gov (United States)

2010-10-20

...] Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal AGENCY: Food... announcing that Arcadia Biosciences, Inc., has filed a petition proposing that the food additive regulations..., Davis, CA 95618. The petition proposes to amend the food additive regulations in part 573 Food Additives...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 2. Splicing ... Articles Volume 36 Issue 2 June 2011 pp 281-287 ... One proband had mutation at the canonical splice site at +5 position of IVS22, and analysis of the transcripts in this family revealed skipping of exon 22 in three members of this family. In one proband ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 28; Issue 4. Volume 28, Issue 4. June 2003, pages 359-528. pp 359-360. Clipboard: Severe acute respiratory syndrome (SARS): an old virus jumping into a new host or a new creation? M S Shaila · More Details Fulltext PDF. pp 361-362. Clipboard: Blueprint of a red mould: ...

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

2008-01-31

Jan 31, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 1. Biological time is fractal: Early events reverberate over a life time. David Lloyd. Perspectives Volume 33 Issue 1 March 2008 pp 9-19. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/033/01/0009- ...

Anti-neutrino disintegration of the deuteron

International Nuclear Information System (INIS)

Mueller, W.; Gari, M.; Max-Planck-Institut fuer Chemie

1981-01-01

The anti-neutrino disintegration of the deuteron (anti ν + D → anti ν + n + p and anti νsub(e) + D → + e + + n + n) is calculated using realistic two-body states. Meson-exchange currents are considered in the one-boson-exchange limit. The results are discussed as corrections to the cross sections obtained in effective range approximations. It is shown that the ratio of the cross sections (sigma - /sigma 0 ) for reactor antineutrinos is practically independent of the nuclear physics uncertainties. (orig.)

Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience.

Science.gov (United States)

Aicardi, Christine

2016-02-01

The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a 'cross-worlds influencer' who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise 'un-disciplined' new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against 'vitalism': anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of 'doing science' and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: 'follow the cross-worlds influencers' who worked to build and organise these semi-institutional gatherings and institutional structures. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience

Science.gov (United States)

Aicardi, Christine

2016-01-01

The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a ‘cross-worlds influencer’ who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise ‘un-disciplined’ new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against ‘vitalism’: anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of ‘doing science’ and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: ‘follow the cross-worlds influencers’ who worked to build and organise these semi-institutional gatherings and institutional structures. PMID:26383132

Absence of anti-HMG-CoA reductase autoantibodies in severe self-limited statin-related myopathy.

Science.gov (United States)

Floyd, James S; Brody, Jennifer A; Tiniakou, Eleni; Psaty, Bruce M; Mammen, Andrew

2016-06-01

Patients with self-limited statin-related myopathy improve spontaneously when statins are stopped. In contrast, patients with statin-associated autoimmune myopathy have autoantibodies recognizing 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) and usually require immunosuppressive therapy to control their disease. On initial presentation, it can sometimes be difficult to distinguish between these 2 diseases, as both present with muscle pain, weakness, and elevated serum creatine kinase (CK) levels. The goal of this study was to determine whether patients with severe self-limited statin-related myopathy also make anti-HMGCR autoantibodies. We screened 101 subjects with severe self-limited cerivastatin-related myopathy for anti-HMGCR autoantibodies. No patient with severe self-limited cerivastatin-related myopathy had anti-HMGCR autoantibodies. Anti-HMGCR autoantibody testing can be used to help differentiate whether a patient has self-limited myopathy due to cerivastatin or autoimmune statin-associated myopathy; these findings may apply to other statins as well. Muscle Nerve 54: 142-144, 2016. © 2016 Wiley Periodicals, Inc.

Predictors of academic performance in the discipline-specific bioscience paper: a retrospective qualitative study.

Science.gov (United States)

Khareedi, R

2018-05-01

The cohort of students enrolled in the discipline-specific bioscience paper reflects a structural diversity in that it includes students of multiple ethnicities, varied age groups, differing scholastic and life experiences. These divergent identities of students are known to influence academic performance. The purpose of this retrospective quantitative study was to determine the ability of a set of variables such as age, gender, ethnicity, level of prior education, the place from which prior education was obtained, work experience and prior academic achievement to predict academic performance in the discipline-specific bioscience paper. The sample for this study was a purposive sample of all oral health students who had enrolled in the paper at the Auckland University of Technology from 2011 to 2014. The desensitised empirical data of 116 students from the University's database were subject to multivariable regression analysis. Pearson's correlation coefficients were calculated. Prior academic achievement was a statistically significant predictor variable (P academic performance in the discipline-specific bioscience paper and was also positively correlated (r = 0.641, P academic achievement was the only variable that was demonstrated to be correlated to and predictive of the academic performance in the discipline-specific bioscience paper. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Evaluation of a modified IRMA for anti-D quantitation, using 3H protein A

International Nuclear Information System (INIS)

Dumasia, A.; Gupte, S.

1993-01-01

A modified immunoradiometric assay (IRMA) using tritiated ( 3 H) protein A was developed to estimate anti-D concentration. The main advantages of the assay were longer shelf life of the labelled reagent (more than two years); minimum radiation hazard and; low non specific binding. Levels of anti-D were estimated in 23 Rh (D) immunized women. A good correlation of anti-D concentration (μg/ml) with Rh antibody titre was observed (r=+ 0.89, P 3 H protein A IRMA correlated well with the severity of Rh-HDN. This assay could quantitate anti-D in sera having exclusively IgG 3 subtype. (author). 20 refs., 2 figs., 2 tabs

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 36; Issue 1. P1 peptidase – a mysterious protein of family Potyviridae. Jana Rohožková Milan Navrátil ... The coding region for P1 peptidase is located at the very beginning of the viral genome of the family Potyviridae. Until recently P1 was thought of as serine peptidase with ...

Interpretation of Y(4390) as an isoscalar partner of Z(4430) from D*(2010) anti D{sub 1}(2420) interaction

Energy Technology Data Exchange (ETDEWEB)

He, Jun [Nanjing Normal University, Department of Physics and Institute of Theoretical Physics, Nanjing (China); Chen, Dian-Yong [Southeast University, School of Physics, Nanjing (China)

2017-06-15

Invoked by the recent observation of Y(4390) at BESIII, which is about 40 MeV below the D*(2010) anti D{sub 1}(2420) threshold, we investigate possible bound and resonance states from the D*(2010) anti D{sub 1}(2420) interaction with the one-boson-exchange model in a quasipotential Bethe-Salpeter equation approach. A bound state with quantum number 0{sup -}(1{sup --}) is produced at 4384 MeV from the D*(2010) anti D{sub 1}(2420) interaction, which can be related to experimentally observed Y(4390). Another state with quantum number 1{sup +}(1{sup +}) is also produced at 4461 + i39 MeV from this interaction. Different from the 0{sup -}(1{sup --}) state, the 1{sup +}(1{sup +}) state is a resonance state above the D*(2010) anti D{sub 1}(2420) threshold. This resonance state can be related to the first observed charged charmonium-like state Z(4430), which has a mass about 4475 MeV measured above the threshold as observed at Belle and LHCb. Our result suggests that Y(4390) is an isoscalar partner of the Z(4430) as a hadronic-molecular state from the D*(2010) anti D{sub 1}(2420) interaction. (orig.)

Auto-immune anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis: three case reports.

Science.gov (United States)

Bashiri, Fahad A; Al-Rasheed, Abdulrahman A; Hassan, Saeed M; Hamad, Muddathir H A; El Khashab, Heba Y; Kentab, Amal Y; AlBadr, Fahad B; Salih, Mustafa A

2017-08-01

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a recently identified auto-immune disorder characterised by severe memory deficit, a decreased level of consciousness, seizures, autonomic dysfunction and movement disorders. Three girls with the disorder are reported; they were aged 4 years, 5 years and 10 months. The 10-month-old infant who is one of the youngest patients reported with anti-NMDAR encephalitis worldwide, had MRI features suggestive of herpes simplex encephalitis (known to trigger anti-NMDAR encephalitis), but CSF PCR for herpes simplex was negative. All the patients presented with seizures, behavioural change, regression of speech, dystonia and choreo-athetosis. Anti-NMDAR antibodies were detected in all patients' sera and cerebrospinal fluid (CSF). Intravenous immunoglobulin, corticosteroids and rituximab were administered at different intervals. Cases 1 and 2 made a full recovery, but case 3 has mild motor and speech delay. Patients who present with encephalopathy, seizures and movement disorders should be tested for anti-NMDAR antibodies in serum and CSF in addition to being screened for herpes simplex encephalitis.

[Clinical effect of anti-D immunoglobulin in treatment of childhood immune thrombocytopenia: a Meta analysis].

Science.gov (United States)

Qin, Wei; Huang, Shao-Ling; Li, Ting-Ting

2017-10-01

To investigate the clinical effect and safety of anti-D immunoglobulin (anti-D) in the treatment of children with newly diagnosed acute immune thrombocytopenia (ITP) through a Meta analysis. PubMed, EMBASE, Cohrane Library, Ovid, CNKI, and Wanfang Data were searched for randomized controlled trials (RCTs) published up to April 2017. Review Manager 5.3 was used for the Meta analysis. Seven RCTs were included. The Meta analysis showed that after 72 hours and 7 days of treatment, the intravenous immunoglobulin (IVIG) group had a significantly higher percentage of children who achieved platelet count >20×10 9 /L than the anti-D group (Panti-D (50 μg/kg) group and the IVIG group (P>0.05), and there were also no significant differences in platelet count after 24 hours and 7 days of treatment between the 50 μg/kg and 75 μg/kg anti-D groups (P>0.05). The anti-D group had a significantly greater reduction in the hemoglobin level than the IVIG group after treatment, but did not need transfusion. No children in the anti-D group or the IVIG group experienced serious adverse reactions. Intravenous injection of anti-D may have a similar effect as IVIG in improving platelet count in children with acute ITP, but it may be slightly inferior to IVIG in the rate of platelet increase after treatment. The anti-D dose of 50 μg/kg may have a similar effect as 75 μg/kg. The recommended dose of anti-D for treatment of ITP is safe.

Can active learning principles be applied to the bioscience assessments of nursing students? A review of the literature.

Science.gov (United States)

Bakon, Shannon; Craft, Judy; Christensen, Martin; Wirihana, Lisa

2016-02-01

To explore if active learning principles be applied to nursing bioscience assessments and will this influence student perception of confidence in applying theory to practice? A review of the literature utilising searches of various databases including CINAHL, PUBMED, Google Scholar and Mosby's Journal Index. The literature search identified research from twenty-six original articles, two electronic books, one published book and one conference proceedings paper. Bioscience has been identified as an area that nurses struggle to learn in tertiary institutions and then apply to clinical practice. A number of problems have been identified and explored that may contribute to this poor understanding and retention. University academics need to be knowledgeable of innovative teaching and assessing modalities that focus on enhancing student learning and address the integration issues associated with the theory practice gap. Increased bioscience education is associated with improved patient outcomes therefore by addressing this "bioscience problem" and improving the integration of bioscience in clinical practice there will subsequently be an improvement in health care outcomes. From the literature several themes were identified. First there are many problems with teaching nursing students bioscience education. These include class sizes, motivation, concentration, delivery mode, lecturer perspectives, student's previous knowledge, anxiety, and a lack of confidence. Among these influences the type of assessment employed by the educator has not been explored or identified as a contributor to student learning specifically in nursing bioscience instruction. Second that educating could be achieved more effectively if active learning principles were applied and the needs and expectations of the student were met. Lastly, assessment influences student retention and the student experience and as such assessment should be congruent with the subject content, align with the learning

Pediatric Opsoclonus-Myoclonus-Ataxia Syndrome Associated With Anti-N-methyl-D-aspartate Receptor Encephalitis.

Science.gov (United States)

Player, Brittany; Harmelink, Matthew; Bordini, Brett; Weisgerber, Michael; Girolami, Michael; Croix, Michael

2015-11-01

The full clinical spectrum of anti-N-methyl-D-aspartate receptor encephalitis is unknown in the pediatric population. We describe a previously healthy 4-year-old girl presenting with opsoclonus-myoclonus together with ataxia who had NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the cerebral spinal fluid. The presence of NR1-specific, anti-N-methyl-D-aspartate receptor antibodies in the setting of opsoclonus-myoclonus and ataxia syndrome may represent an expansion of the clinical presentations of anti-N-methyl-D-aspartate receptor encephalitis. Copyright © 2015 Elsevier Inc. All rights reserved.

Risk Factors for RhD Immunisation Despite Antenatal and Postnatal Anti-D Prophylaxis COMMENT

NARCIS (Netherlands)

Koelewijn, J. M.; de Haas, M.; Vrijkotte, T. G. M.; van der Schoot, C. E.; Bonsel, G. J.

2010-01-01

Despite routine antenatal and postnatal administration of anti-D immunoglobulin (Ig) during pregnancy and delivery in a previous pregnancy, 0.1% to 0.3% of women are found to have Rhesus D (RhD) antibodies in their next pregnancy. The primary aim of this case-control study was to identify causative

3D-Printed Broadband Dielectric Tube Terahertz Waveguide with Anti-Reflection Structure

Science.gov (United States)

Vogt, Dominik Walter; Leonhardt, Rainer

2016-11-01

We demonstrate broadband, low loss, and close-to-zero dispersion guidance of terahertz (THz) radiation in a dielectric tube with an anti-reflection structure (AR-tube waveguide) in the frequency range from 0.2 to 1.0 THz. The anti-reflection structure (ARS) consists of close-packed cones in a hexagonal lattice arranged on the outer surface of the tube cladding. The feature size of the ARS is in the order of the wavelength between 0.2 and 1.0 THz. The waveguides are fabricated with the versatile and cost efficient 3D-printing method. Terahertz time-domain spectroscopy (THz-TDS) measurements as well as 3D finite-difference time-domain simulations (FDTD) are performed to extensively characterize the AR-tube waveguides. Spectrograms, attenuation spectra, effective phase refractive indices, and the group-velocity dispersion parameters β 2 of the AR-tube waveguides are presented. Both the experimental and numerical results confirm the extended bandwidth and smaller group-velocity dispersion of the AR-tube waveguide compared to a low loss plain dielectric tube THz waveguide. The AR-tube waveguide prototypes show an attenuation spectrum close to the theoretical limit given by the infinite cladding tube waveguide.

Nitrogen-15 reference book: medicine and biosciences

International Nuclear Information System (INIS)

Faust, H.

1983-04-01

A comprehensive bibliography on the application of the stable nitrogen isotope 15 N in medicine, animal nutrition and physiology, biosciences, and related disciplines is presented. The literature pertaining to this paper covers the period from 1977 to 1981. The references are completed by an index of all authors and a subject index with special emphasis to the used organisms, labelled compounds, and tracer techniques, respectively. (author)

Low Serum Vitamin D Is Associated with Anti-Thyroid Peroxidase Antibody in Autoimmune Thyroiditis

OpenAIRE

Shin, Dong Yeob; Kim, Kwang Joon; Kim, Daham; Hwang, Sena; Lee, Eun Jig

2014-01-01

Purpose The association between autoimmune thyroid diseases (AITDs) and vitamin D deficiency is controversial. We aimed to evaluate the relationship between serum 25-hydroxy-vitamin D3 [25(OH)D3] and anti-thyroid antibody levels. Materials and Methods 25(OH)D3, anti-thyroid antibodies, and thyroid function measured in 304 patients who visited the endocrinology clinic were analyzed. The patients were subgrouped into the AITDs or non-AITDs category according to the presence or absence of anti-t...

Discrete Torsion, (Anti) de Sitter D{sub 4}-Brane and Tunneling

Energy Technology Data Exchange (ETDEWEB)

Singh, Abhishek K.; Pandey, P.K.; Singh, Sunita; Kar, Supriya, E-mail: skkar@physics.du.ac.in

2014-06-15

We obtain quantum geometries on a vacuum created pair of a (DD{sup ¯}){sub 3}-brane, at a Big Bang singularity, by a local two form on a D{sub 4}-brane. In fact our analysis is provoked by an established phenomenon leading to a pair creation by a gauge field at a black hole horizon by Stephen Hawking in 1975. Importantly, the five dimensional microscopic black holes are described by an effective non-perturbative curvature underlying a discrete torsion in a second order formalism. In the case for a non-propagating torsion, the effective curvature reduces to Riemannian, which in a low energy limit may describe Einstein vacuum in the formalism. In particular, our analysis suggests that a non-trivial space begin with a hot de Sitter brane-Universe underlying a nucleation of a vacuum pair of (DD{sup ¯})-instanton at a Big Bang. A pair of instanton nucleats a D-particle which in turn combines with an anti D-particle to describe a D-string and so on. The nucleation of a pair of higher dimensional pair of brane/anti-brane from a lower dimensional pair may be viewed via an expansion of the brane-Universe upon time. It is in conformity with the conjecture of a branes within a brane presumably in presence of the non-zero modes of two form. Interestingly, we perform a thermal analysis underlying various emergent quantum de Sitter vacua on a D{sub 4}-brane and argue for the plausible tunneling geometries underlying a thermal equilibrium. It is argued that a de Sitter Schwarzschild undergoes quantum tunneling to an AdS-brane Schwarzschild via Nariai and de Sitter topological black hole.

Human anti-rhesus D IgG1 antibody produced in transgenic plants

DEFF Research Database (Denmark)

Bouquin, Thomas; Thomsen, Mads; Nielsen, Leif Kofoed

2002-01-01

antigen, which is responsible for alloimmunization of RhD- mothers carrying an RhD+ fetus. Anti-RhD extracted from plants specifically reacted with RhD+ cells in antiglobulin technique, and elicited a respiratory burst in human peripheral blood mononuclear cells. Plant-derived antibody had equivalent......Transgenic plants represent an alternative to cell culture systems for producing cheap and safe antibodies for diagnostic and therapeutic use. To evaluate the functional properties of a 'plantibody', we generated transgenic Arabidopsis plants expressing full-length human IgG1 against the Rhesus D...... properties to CHO cell-produced anti-RhD antibody, indicating its potential usefulness in diagnostic and therapeutic programs....

Anti-D3 branes and moduli in non-linear supergravity

Science.gov (United States)

Garcia del Moral, Maria P.; Parameswaran, Susha; Quiroz, Norma; Zavala, Ivonne

2017-10-01

Anti-D3 branes and non-perturbative effects in flux compactifications spontaneously break supersymmetry and stabilise moduli in a metastable de Sitter vacua. The low energy 4D effective field theory description for such models would be a supergravity theory with non-linearly realised supersymmetry. Guided by string theory modular symmetry, we compute this non-linear supergravity theory, including dependence on all bulk moduli. Using either a constrained chiral superfield or a constrained vector field, the uplifting contribution to the scalar potential from the anti-D3 brane can be parameterised either as an F-term or Fayet-Iliopoulos D-term. Using again the modular symmetry, we show that 4D non-linear supergravities that descend from string theory have an enhanced protection from quantum corrections by non-renormalisation theorems. The superpotential giving rise to metastable de Sitter vacua is robust against perturbative string-loop and α' corrections.

Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Adult Patients Requiring Intensive Care.

Science.gov (United States)

de Montmollin, Etienne; Demeret, Sophie; Brulé, Noëlle; Conrad, Marie; Dailler, Frédéric; Lerolle, Nicolas; Navellou, Jean-Christophe; Schwebel, Carole; Alves, Mikaël; Cour, Martin; Engrand, Nicolas; Tonnelier, Jean-Marie; Maury, Eric; Ruckly, Stéphane; Picard, Géraldine; Rogemond, Véronique; Magalhaes, Éric; Sharshar, Tarek; Timsit, Jean-François; Honnorat, Jérôme; Sonneville, Romain

2017-02-15

Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. To identify prognostic factors of good neurologic outcome in patients admitted to an ICU with anti-NMDAR encephalitis. This was an observational multicenter study of all consecutive adult patients diagnosed with anti-NMDAR encephalitis at the French National Reference Centre, admitted to an ICU between 2008 and 2014. The primary outcome was a good neurologic outcome at 6 months after ICU admission, defined by a modified Rankin Scale score of 0-2. Seventy-seven patients were included from 52 ICUs. First-line immunotherapy consisted of steroids (n = 61/74; 82%), intravenous immunoglobulins (n = 71/74; 96%), and plasmapheresis (n = 17/74; 23%). Forty-five (61%) patients received second-line immunotherapy (cyclophosphamide, rituximab, or both). At 6 months, 57% of patients had a good neurologic outcome. Independent factors of good neurologic outcome were early (≤8 d after ICU admission) immunotherapy (odds ratio, 16.16; 95% confidence interval, 3.32-78.64; for combined first-line immunotherapy with steroids and intravenous immunoglobulins vs. late immunotherapy), and a low white blood cell count on the first cerebrospinal examination (odds ratio, 9.83 for 50 cells/mm 3 ; 95% confidence interval, 1.07-90.65). Presence of nonneurologic organ failures at ICU admission and occurrence of status epilepticus during ICU stay were not associated with neurologic outcome. The prognosis of adult patients with anti-NMDAR encephalitis requiring intensive care is good, especially when immunotherapy is initiated early, advocating for prompt diagnosis and early aggressive treatment.

SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends

International Nuclear Information System (INIS)

2010-01-01

Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

Measurement of D+s meson production in Z decays and of the anti B0s lifetime

International Nuclear Information System (INIS)

Buskulic, D.; Casper, D.; Bonis, I. de

1996-01-01

D + s mesons produced in Z 0 →b anti b events were separated from the Z 0 →c anti c component using a lifetime tag. Using a sample of 1.5 million hadronic Z decays collected with the ALEPH detector the anti B 0 s and D + s yields have been measured: B(b→ anti B 0 s )B(anti B 0 s →D + s )=0.088±0.020(stat.)±0.020(syst.), B(c→D + s )=0.128±0.019(stat.) +0.019 -0.016 (syst.). The anti B 0 s lifetime was measured in a anti B 0 s enriched sample reconstructing the decay length from the vertex of the D + s with a hadron from the anti B 0 s decay. The result obtained is: τ B s =1.61 +0.30 -0.29 (stat.) +0.18 -0.16 (syst.) ps. (orig.)

Serum uric acid and anti-N-methyl-d-aspartate receptor encephalitis.

Science.gov (United States)

Shu, Yaqing; Wang, Yuge; Lu, Tingting; Li, Rui; Sun, Xiaobo; Li, Jing; Chang, Yanyu; Hu, Xueqiang; Lu, Zhengqi; Qiu, Wei

2017-09-01

Uric acid (UA) levels are associated with autoimmune and neurodegenerative disorders, but their relationship with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis is unknown. UA levels were evaluated in 58 patients with anti-NMDAR encephalitis, and 58 age- and sex-matched healthy controls (CTLs). Follow-up evaluations of 30 out of the 58 patients with anti-NMDAR encephalitis were conducted 3 months after admission. Modified Rankin scale (mRS) scores and clinical and cerebrospinal fluid parameters were evaluated in all anti-NMDAR encephalitis patients. Serum UA levels were significantly lower in patients with anti-NMDAR encephalitis than those in CTLs (p anti-NMDAR encephalitis are reduced during attacks compared with those in CTLs, are normalized after treatment, and are associated with disease severity. Copyright © 2017. Published by Elsevier Ltd.

Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn.

Science.gov (United States)

Brinc, Davor; Lazarus, Alan H

2009-01-01

Anti-D is routinely and effectively used to prevent hemolytic disease of the fetus and newborn (HDFN) caused by the antibody response to the D antigen on fetal RBCs. Anti-D is a polyclonal IgG product purified from the plasma of D-alloimmunized individuals. The mechanism of anti-D has not been fully elucidated. Antigenic epitopes are not fully masked by anti-D and are available for immune system recognition. However, a correlation has frequently been observed between anti-D-mediated RBC clearance and prevention of the antibody response, suggesting that anti-D may be able to destroy RBCs without triggering the adaptive immune response. Anti-D-opsonized RBCs may also elicit inhibitory FcgammaRIIB signaling in B cells and prevent B cell activation. The ability of antigen-specific IgG to inhibit antibody responses has also been observed in a variety of animal models immunized with a vast array of different antigens, such as sheep RBCs (SRBC). This effect has been referred to as antibody-mediated immune suppression (AMIS). In animal models, IgG inhibits the antibody response, but the T-cell response and memory may still be intact. IgG does not mask all epitopes, and IgG-mediated RBC clearance or FcgammaRIIB-mediated B-cell inhibition do not appear to mediate the AMIS effect. Instead, IgG appears to selectively disrupt B cell priming, although the exact mechanism remains obscure. While the applicability of animal models of AMIS to understanding the true mechanism of anti-D remains uncertain, the models have nevertheless provided us with insights into the possible IgG effects on the immune response.

Full text and figure display improves bioscience literature search.

Science.gov (United States)

Divoli, Anna; Wooldridge, Michael A; Hearst, Marti A

2010-04-14

When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

Full text and figure display improves bioscience literature search.

Directory of Open Access Journals (Sweden)

Anna Divoli

Full Text Available When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

Science.gov (United States)

Mayne, Lynne

2012-01-01

To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

Saponins from Panax japonicus attenuate D-galactose-induced cognitive impairment through its anti-oxidative and anti-apoptotic effects in rats.

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Wang, Ting; Di, Guojie; Yang, Li; Dun, Yaoyan; Sun, Zhiwei; Wan, Jingzhi; Peng, Ben; Liu, Chaoqi; Xiong, Guangrun; Zhang, Changcheng; Yuan, Ding

2015-09-01

To investigate the neuroprotective effects of saponins from Panax japonicus (SPJ) on D-galactose (D-gal)-induced brain ageing, and further explore the underlying mechanisms. SPJ were analysed using high-pressure liquid chromatography. Male Wistar rats weighing 200 ± 20 g were randomly divided into four groups: control group (saline), D-gal-treated group (400 mg/kg, subcutaneously), D-gal + SPJ groups (50, 100 and 200 mg/kg, orally) and vitamin E group (100 mg/kg). Rats were injected corresponding drugs once daily for 8 weeks. Neuroprotective effects of SPJ were evaluated by Morris water maze, histopathological observations, biochemical assays, western blot analysis and quantitative real-time polymerase chain reaction (PCR) analysis in vivo as well as reactive oxygen species (ROS) measurement and apoptosis assay in vitro. Our present study showed that D-gal had a neurotoxic effect in rats and in SH-SY5Y cells due to oxidative stress induction, including decreased total anti-oxidant capacity, superoxide dismutase (SOD) and glutathione peroxidase activity, ultimately leading to spatial learning and memory impairment in rats and ROS accumulation in SH-SY5Y cells. SPJ improved spatial learning and memory deficits, attenuated hippocampus histopathological injury and restored impaired anti-oxidative as well as anti-apoptotic capacities in D-gal-induced ageing rats. In addition, SPJ remarkably decreased lipofuscin levels, increased hippocampus nuclear factor erythroid 2-related factor 2 (Nrf2) and silent mating type information regulation 2 homologue (SIRT1) protein levels and anti-oxidant genes expression such as manganese superoxide dismutase (Mn-SOD), heme oxygenase (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1) and cysteine ligase catalytic (GCLC) in D-gal-induced brain ageing. Our data suggested that D-gal induced multiple molecular and functional changes in brain similar to natural ageing process. SPJ protected brain from D-gal-induced neuronal

Enhanced opsonisation of Rhesus D-positive human red blood cells by recombinant polymeric immunoglobulin G anti-G antibodies.

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Díaz-Solano, Dylana; Fuenmayor, Jaheli; Montaño, Ramon F

2018-02-01

Anti-RhD antibodies (anti-D) are important in the prophylaxis of haemolytic disease of the foetus and newborn (HDFN) due to RhD incompatibility. Current preparations of anti-D are sourced from hyperimmune human plasma, so its production carries a risk of disease and is dependent on donor availability. Despite the efforts to develop a monoclonal preparation with similar prophylactic properties to the plasma-derived anti-D, no such antibody is yet available. Here we studied the agglutinating, opsonic and haemolytic activities of two recombinant polymeric immunoglobulins (Ig) against the G antigen of the Rh complex. Recombinant polymeric anti-G IgG1 (IgG1μtp) and IgG3 (IgG3μtp) were produced in vitro, purified by protein G-affinity chromatography, and analysed by gel electrophoresis. Their agglutinating, opsonic and haemolytic activities were evaluated using haemagglutination, erythrophagocytosis, and complement activation assays. The recombinant IgG1μtp and IgG3μtp anti-G antibodies ranged from 150,000 to 1,000,000 Da in molecular weight, indicating the formation of polymeric IgG. No complement activation or haemolytic activity was detected upon incubation of RhD-positive red-blood cells with the polymeric anti-G IgG. Both polymers were better opsonins than a prophylactic preparation of plasma-derived anti-D. The enhanced opsonic properties of the polymeric anti-G IgG1μtp and IgG3μtp could allow them to mediate the clearance of RhD-positive red blood cells from circulation more efficiently than natural or other synthetic prophylactic anti-D options. Their inability to induce complement-mediated haemolysis would be prophylactically convenient and is comparable in vitro to that of the available plasma-derived polyclonal anti-D preparations. The described properties suggest that polymeric antibodies like these (but with anti-D specificity) may be testable candidates for prophylaxis of HDFN caused by anti-D.

Use of cffDNA to avoid administration of anti-D to pregnant women when the fetus is RhD-negative: implementation in the NHS.

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Soothill, P W; Finning, K; Latham, T; Wreford-Bush, T; Ford, J; Daniels, G

2015-11-01

To determine whether a policy of offering cffDNA testing to all RhD-negative women at about 16 weeks' gestation to avoid anti-D administration when the fetus is RhD-negative could be implemented successfully in the NHS without additional funding. Prospectively planned observational service implementation pilot and notes audit. Three maternity services in the South West of England. All RhD-negative women in a 6-month period. Prospective, intervention, cross-sectional observational study, using pre-intervention data as controls. Proportion of suitable women who offered and accepted the test. Accuracy of the cffDNA result as assessed by cord blood group result. Fall in anti-D doses administered. 529 samples were received; three were unsuitable. The results were reported as RhD-positive (n = 278), RhD-negative (n = 185) or inconclusive, treat as positive (n = 63). Cord blood results were available in 502 (95%) and the only incorrect result was one case of a false positive (cffDNA reported as positive, cord blood negative - and so given anti-D unnecessarily). The notes audit showed that women who declined this service were correctly managed and that anti-D was not given when the fetus was predicted to be RhD-negative. The total use of anti-D doses fell by about 29% which equated to about 35% of RhD-negative women not receiving anti-D in their pregnancy unnecessarily. We recommend this service is extended to all UK NHS services. © 2014 Royal College of Obstetricians and Gynaecologists.

Erratum Journal of Biosciences Volume 34, Number 2, November ...

Indian Academy of Sciences (India)

Prakash

(1) Page 709, Introduction, 4th line from top: 3500 m to be read as 500 m. (2) Page 710, Figure 2 caption, line 1: 3500 m to be read as 500 m. The above corrections require to be made in the printed version of the article. The article that appear on the Journal of. Biosciences Web site will contain these corrections.

Anti-D treatment for pediatric immune thrombocytopenia: Is the bad reputation justified?

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Yacobovich, Joanne; Abu-Ahmed, Sabreen; Steinberg-Shemer, Orna; Goldberg, Tracie; Cohen, Miriam; Tamary, Hannah

2016-04-01

The purpose of this study was to assess the efficacy and side effect profile of the repeated use of anti-D for the treatment of pediatric immune thrombocytopenia (ITP) in a large pediatric hematology center. We performed a retrospective analysis of patient records for children (aged 4 months-18 years) treated for ITP at Schneider Children's Medical Center of Israel from 1995-2015. Demographic and clinical data, reported adverse events, and therapy response were extracted from written and electronic files for all patients having received anti-D. Therapy response was defined as time to platelet count >30 x 10(9)/L. Thirty-six patients received 170 treatments of anti-D at a dose of 75 μg/kg. The majority were previously treated with corticosteroids and/or intravenous immunoglobulin (IVIG). Minimal adverse events were recorded including fever (3.5%), vomiting (2.9%), and headaches (1.7%). Notably only 1/170 treatments required blood transfusion and no life-threatening events occurred. The average time to platelets >30 x 10(9)/L was 2.3 days, with a median of 1 day, range 1-12 days. Despite the reported severe adverse events in mainly elderly patients, the use of anti-D can be safe and effective in carefully chosen, low-risk pediatric patients with ITP. Copyright © 2016 Elsevier Inc. All rights reserved.

Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class

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Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija

2015-01-01

University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…

Serum cystatin C and anti-N-methyl-D-aspartate receptor encephalitis.

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Shu, Y; Chang, Y; Wu, H; Li, J; Cao, B; Sun, X; Wang, J; Peng, L; Hu, X; Yu, X; Qiu, W

2018-05-01

Cystatin C (CysC) is associated with many neurodegenerative disorders and autoimmune diseases, but its relationship with anti-N-Methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unknown. Serum levels of CysC were determined in 66 patients with anti-NMDAR encephalitis and 115 healthy controls. Of the 66 patients, 30 had a follow-up evaluation at 3 months after admission. Association of CysC with anti-NMDAR encephalitis and its clinical parameters were evaluated in the patients. The serum levels of CysC were significantly lower in patients with anti-NMDAR encephalitis than in controls (0.70 ± 0.13 vs 0.83 ± 0.17 mg/mL, P anti-NMDAR encephalitis patients had significantly increased serum CysC levels (P anti-NMDAR encephalitis and its clinical parameters and that the changes in CysC levels correlate with therapeutic effect. Therefore, our findings provide new insights into the association between serum CysC and anti-NMDAR encephalitis. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Introducing bioinformatics, the biosciences' genomic revolution

CERN Document Server

Zanella, Paolo

1999-01-01

The general audience for these lectures is mainly physicists, computer scientists, engineers or the general public wanting to know more about what’s going on in the biosciences. What’s bioinformatics and why is all this fuss being made about it ? What’s this revolution triggered by the human genome project ? Are there any results yet ? What are the problems ? What new avenues of research have been opened up ? What about the technology ? These new developments will be compared with what happened at CERN earlier in its evolution, and it is hoped that the similiraties and contrasts will stimulate new curiosity and provoke new thoughts.

Preface for the special issue of Mathematical Biosciences and Engineering, BIOCOMP 2012.

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Buonocore, Aniello; Di Crescenzo, Antonio; Hastings, Alan

2014-04-01

The International Conference "BIOCOMP2012 - Mathematical Modeling and Computational Topics in Biosciences'', was held in Vietri sul Mare (Italy), June 4-8, 2012. It was dedicated to the Memory of Professor Luigi M. Ricciardi (1942-2011), who was a visionary and tireless promoter of the 3 previous editions of the BIOCOMP conference series. We thought that the best way to honor his memory was to continue the BIOCOMP program. Over the years, this conference promoted scientific activities related to his wide interests and scientific expertise, which ranged in various areas of applications of mathematics, probability and statistics to biosciences and cybernetics, also with emphasis on computational problems. We are pleased that many of his friends and colleagues, as well as many other scientists, were attracted by the goals of this recent event and offered to contribute to its success.

Maternal hepatitis C (HCV) infection and Anti-D immunoglobulin therapy: study testing antibodies, RNA and Genotype of HCV in Baghdad.

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Al-Kubaisy, Waqar; Daud, Suzanna; Al-Kubaisi, Mustafa Waseem; Al-Kubaisi, Omar Waseem; Abdullah, Nik Nairan

2018-04-30

Hepatitis C virus (HCV) infection is a serious health problem. It is a major contributor to end-stage liver disease. Worldwide, 1-8% of all pregnant women were infected. Women with viral hepatitis may be at an increased risk of pregnancy complications. There are several obstetrics intervention acts as risk factors, which are specific to women pertaining the HCV infection; anti-D immunoglobulin (Ig) therapy may be one of them. Our objectives were to estimate the prevalence of HCV antibodies (anti-HCV), RNA, and genotype distribution among women with anti-D Ig therapy. A cross sectional study was conducted. A sample of 154 Rhesus negative (Rh - ve) pregnant women regardless of the anti-D Ig therapy was collected. Anti-HCV were tested using third generation enzyme immunoassay (EIA-3) and immunoblot assay (Lia Tek-111), subsequently. In addition, 89 serum samples were subjected to molecular analysis using RT-PCR and DNA enzyme immunoassay (DEIA) method for the detection of HCV-RNA and genotypes. Anti-HCV, and HCV-RNA seroprevalence were significantly higher (17.1, 35.5%) among women with anti-D Ig than their counter group (6.4, 13.16%), p = .038, .018, respectively. Significant direct positive dose response correlation (r = 0.78, p = .005) had been seen between number of anti-D Ig therapy and anti-HCV seropositive rate. Anti-D Ig therapy act as a risk factor (odds ratio (OR) = 3.01, 95%CI: 1.01-8.9) especially from the third dose onward. Women with anti-D Ig therapy were at higher risk (3.6 times more) of positive HCV-RNA (OR =3.6, 95%CI =1.19-10.837). Genotype HCV-1b showed higher prevalent (52.9%) among the recipients of anti-D Ig therapy while genotype HCV-3a (6.6%) was the lowest. Our study showed that Anti-D immunoglobulin therapy acts as a risk factor for acquiring HCV infection. Screening for HCV should be recommended for all recipients of anti-D Ig. Not only HCV antibodies but HCV-RNA detection being recommended for the diagnosis of HCV

Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.

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Gong, Xiaobao; Yang, You; Huang, Ligua; Zhang, Qingyan; Wan, Rong-Zhen; Zhang, Peng; Zhang, Baoshun

2017-05-01

To evaluate the hepatoprotective effects and potential mechanisms of paeonol (Pae) against acute liver failure (ALF) induced by lipopolysaccharide (LPS)/d-galactosamine (d-GalN) in mice, we examined anti-oxidative, anti-inflammatory and anti-apoptotic activities of Pae. We found that Pae pretreatment markedly reduced the activities of alanine transaminase and aspartate transaminase as well as the histopathological changes induced by LPS/d-GalN. Catalase, glutathione and superoxide dismutase activities increased and reactive oxygen species activity decreased after Pae treatment compared with LPS/d-GalN treatment. Pretreatment with Pae also significantly inhibited the expression levels of iNOS, nitric oxide (NO), COX-2 and prostaglandin E 2 (PGE 2 ). In addition, Pae administration prevented the phosphorylated expression of IκB kinase, inhibitor kappa B in the nuclear factor-kappa B (NF-κB) signaling pathway, and suppressed the phosphorylated expression of extracellular signal-regulated kinase (ERK), c-jun-N-terminal kinase and p38 in the MAPK signaling pathway. Pretreatment with Pae also inhibited hepatocyte apoptosis by reducing the expression of caspases 3, 8, 9, and Bax, and increasing Bcl-2. In total, protective effects of Pae against LPS/d-GalN-induced ALF in mice are attributed to its antioxidative effect, inflammatory suppression in NF-κB and MARK signaling pathways, and inhibition of hepatocyte apoptosis inhibition. Therefore, Pae can be a potential therapeutic agent in attenuating LPS/d-GalN-induced ALF in the future. Copyright © 2017. Published by Elsevier B.V.

Anti-N-methyl-D-aspartate receptor encephalitis with serum anti-thyroid antibodies and IgM antibodies against Epstein-Barr virus viral capsid antigen: a case report and one year follow-up

Directory of Open Access Journals (Sweden)

Xu Chun-Ling

2011-11-01

Full Text Available Abstract Background Anti-N-methyl-D-aspartate receptor encephalitis is an increasingly common autoimmune disorder mediated by antibodies to certain subunit of the N-methyl-D-aspartate receptor. Recent literatures have described anti-thyroid and infectious serology in this encephalitis but without follow-up. Case presentation A 17-year-old Chinese female patient presented with psychiatric symptoms, memory deficits, behavioral problems and seizures. She then progressed through unresponsiveness, dyskinesias, autonomic instability and central hypoventilation during treatment. Her conventional blood work on admission showed high titers of IgG antibodies to thyroglobulin, thyroid peroxidase and IgM antibodies to Epstein-Barr virus viral capsid antigen. An immature ovarian teratoma was found and removal of the tumor resulted in a full recovery. The final diagnosis of anti-N-methyl-D-aspartate receptor encephalitis was made by the identification of anti-N-methyl-D-aspartate receptor antibodies in her cerebral spinal fluid. Pathology studies of the teratoma revealed N-methyl-D-aspartate receptor subunit 1 positive ectopic immature nervous tissue and Epstein-Barr virus latent infection. She was discharged with symptoms free, but titers of anti-thyroid peroxidase and anti-thyroglobulin antibodies remained elevated. One year after discharge, her serum remained positive for anti-thyroid peroxidase and anti-N-methyl-D-aspartate receptor antibodies, but negative for anti-thyroglobulin antibodies and IgM against Epstein-Barr virus viral capsid antigen. Conclusions Persistent high titers of anti-thyroid peroxidase antibodies from admission to discharge and until one year later in this patient may suggest a propensity to autoimmunity in anti- N-methyl-D-aspartate receptor encephalitis and support the idea that neuronal and thyroid autoimmunities represent a pathogenic spectrum. Enduring anti-N-methyl-D-aspartate receptor antibodies from admission to one year

Comparison between IV immune globulin (IVIG) and anti-D globulin for treatment of immune thrombocytopenia: a randomized open-label study.

Science.gov (United States)

Eghbali, Aziz; Azadmanesh, Peyman; Bagheri, Bahador; Taherahmadi, Hasan; Sadeghi Sedeh, Bahman

2016-08-01

To compare the effect of IV immune globulin (IVIG) and anti-D globulin (anti-D) for treatment of immune thrombocytopenia (ITP) in children. A randomized, open-label, single-center clinical trial was carried out in Amir-Kabir Hospital (Arak, Iran). The study was performed on 60 children with acute and chronic ITP, aged from 1 to 15 years. Patients were randomly assigned (1:1) to 50 μg/kg anti-D or 1 g/kg IVIG. Platelet counting was performed at baseline and at 3, 7, and 14 days after treatment termination. Safety assessment was performed in all patients. Anti-D caused a quicker response on the 3rd day of treatment (P anti-D had lower rate of side effects including fever (P anti-D was associated with rapid rise of platelets compared to IVIG. In addition, anti-D treatment had acceptable safety profile. © 2016 Société Française de Pharmacologie et de Thérapeutique.

Anti-D in a mother, hemizygous for the variant RHD*DNB gene, associated with hemolytic disease of the fetus and newborn.

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Quantock, Kelli M; Lopez, Genghis H; Hyland, Catherine A; Liew, Yew-Wah; Flower, Robert L; Niemann, Frans J; Joyce, Arthur

2017-08-01

Individuals with the partial D phenotype when exposed to D+ red blood cells (RBCs) carrying the epitopes they lack may develop anti-D specific for the missing epitopes. DNB is the most common partial D in Caucasians and the clinical significance for anti-D in these individuals is unknown. This article describes the serologic genotyping results and clinical manifestations in two group D+ babies of a mother presenting as group O, D+ with alloanti-D. The mother was hemizygous for RHD*DNB gene and sequencing confirmed a single-nucleotide change at c.1063G>A. One baby (group A, D+) displayed bilirubinemia at birth with a normal hemoglobin level. Anti-A and anti-D were eluted from the RBCs. For the next ongoing pregnancy, the anti-D titer increased from 32 to 256. On delivery the baby typed group O and anti-D was eluted from the RBCs. This baby at birth exhibited anemia, reticulocytosis, and hyperbilirubinemia requiring intensive phototherapy treatment from Day 0 to Day 9 after birth and was discharged on Day 13. Intravenous immunoglobulin was also administered. Both babies were heterozygous for RHD and RHD*DNB. The anti-D produced by this woman with partial D DNB resulted in a case of hemolytic disease of the fetus and newborn (HDFN) requiring intensive treatment in the perinatal period. Anti-D formed by women with the partial D DNB phenotype has the potential to cause HDFN where the fetus is D+. Women carrying RHD*DNB should be offered appropriate prophylactic anti-D and be transfused with D- RBCs if not already alloimmunized. © 2017 AABB.

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Directory of Open Access Journals (Sweden)

Carol Kilkenny

2014-02-01

Full Text Available In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications themselves are not “fit for purpose”, meaning that incomplete reporting of relevant information effectively renders many publications of limited value as instruments to inform policy or clinical and scientific practice [1–21]. A recent review of clinical research showed that there is considerable cumulative waste of financial resources at all stages of the research process, including as a result of publications that are unusable due to poor reporting [22]. It is unlikely that this issue is confined to clinical research [2–14,16–20].

Ontologies and standards in bioscience research: for machine or for human

Directory of Open Access Journals (Sweden)

Huaiyu eMi

2011-02-01

Full Text Available Ontologies and standards are very important parts of today’s bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to manage and analyze the data. Most of these standards are initially designed for computers to access large amounts of data that are difficult for human biologists to handle, and it is important to keep in mind that ultimately biologists are going to produce and interpret the data. While ontologies and standards must follow strict semantic rules that may not be familiar to biologists, effort must be spent to lower the learning barrier by involving biologists in the process of development, and by providing software and tool support. A standard will not succeed without support from the wider bioscience research community. Thus, it is crucial that these standards be designed not only for machines to read, but also to be scientifically accurate and intuitive to human biologists.

Division of energy biosciences: Annual report and summaries of FY 1995 activities

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-04-01

The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

Anti-tumor effects of (1→3)-β-d-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice.

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Mo, Li; Chen, Yafei; Li, Wenjian; Guo, Shuai; Wang, Xuzhao; An, Hailong; Zhan, Yong

2017-02-01

(1→3)-β-d-Glucan from Saccharomyces cerevisiae is a typical polysaccharide with various biological effects and is considered a candidate for the prevention and treatment of cancer in vitro. Research into the function of (1→3)-β-d-glucan in tumor-bearing animals in vivo, however, is limited. Here, we investigated the effects of (1→3)-β-d-glucan from S. cerevisiae on S180 tumor-bearing mice and on the immunity of the tumor-bearing host. The molecular mechanisms underlying the observed effects were investigated. (1→3)-β-d-Glucan was shown to exert anti-tumor effects without toxicity in normal mouse cells. The volume and weight of S180 tumors decreased dramatically following treatment with (1→3)-β-d-glucan, and treatment with the polysaccharide was furthermore shown to increase the tumor inhibition rate in a dose-dependent manner. Spleen index, T lymphocyte subsets (CD 4 and CD 8 ), as well as interleukins (IL)-2, (IL-2, IL-6), and tumor necrosis factor-α were assayed to detect the immunoregulatory and anti-tumor effects after (1→3)-β-d-glucan intragastrical administration. (1→3)-β-d-Glucan was shown to significantly potentiate the mouse immune responses by, among other effects, decreasing the ratio of CD 4 to CD 8 . The expression levels of IL-2, IL-6, and TNF-α were also significantly increased by (1→3)-β-d-glucan. These results suggest that (1→3)-β-d-glucan enhances the host's immune function during the tumor inhibition process. S180 tumor cells treated with (1→3)-β-d-glucan also exhibited significant apoptotic characteristics. (1→3)-β-d-glucan increased the ratio of Bax to Bcl-2 at the translation level by up-regulating Bax expression and down-regulating Bcl-2 expression, resulting in the initiation of cell apoptosis in S180 tumor-bearing mice. Taken together, these results indicate that the anti-tumor effects exerted by (1→3)-β-d-glucan may be attributed to the polysaccharide's immunostimulating properties and apoptosis

Adolescent with acute psychosis due to anti-N-methyl-D-aspartate receptor encephalitis: successful recovery

OpenAIRE

Jonuskaite, Dovile; Kalibatas, Paulius; Praninskiene, Ruta; Zalubiene, Asta; Jucaite, Aurelija; Cerkauskiene, Rimante

2017-01-01

Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a relatively new autoimmune disorder of the central nervous system. We report the first case of anti-NMDAR autoimmune encephalitis combined with anti-voltage-gated potassium channel (anti-VGKC) antibodies in Lithuania in a 16-year-old girl. The patient was admitted to psychiatry unit because of an acute psychotic episode. She was unsuccessfully treated with antipsychotics, and electroconvulsive therapy was initiated because of he...

Studies on middle silkgland proteins of cocoon colour sex-limited ...

Indian Academy of Sciences (India)

Home; Journals; Journal of Biosciences; Volume 29; Issue 1. Studies on middle silkgland proteins of cocoon colour sex-limited silkworm (Bombyx mori L.) using two-dimensional polyacrylamide gel electrophoresis. Yuan-Xiang Jin Yu-Yin Chen Meng-Kui Xu Yong-Huang Jiang. Articles Volume 29 Issue 1 March 2004 pp 45- ...

Anti-D reagents should be chosen accordingly to the prevalence of D variants in the obstetric population.

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Lukacevic Krstic, Jelena; Dajak, Slavica; Bingulac-Popovic, Jasna; Dogic, Vesna; Mratinovic-Mikulandra, Jela

2018-03-01

Resolving ambiguous results of D antigen typing is crucial for appropriate and rational administration of anti-D immunoprophylaxis and transfusion practice in obstetric population. The aim of the study was to establish selection criteria of anti-D reagents for our population. A total of 12 689 samples from primiparous women in Split-Dalmatia County, Croatia, were typed for RhD antigen during the period of 5 years. Ambiguous results were submitted to additional serologic investigation and genotyping. RHD genotyping was performed by commercial genotyping kits (Ready Gene weak D ® and Ready gene CDE, Inno-Train, Kronberg, Germany). Relative frequencies and accompanying 95% confidence intervals were used to estimate the prevalence of variants. The prevalence of D variants was 0.42% (95% CI 0.31; 0.53). The most common partial D variant was D Va (RHD*05.05), with the prevalence of 0.08% (95% CI 0.03; 0.13). All weak D variants were weak D types 1, 2 and 3 (RHD*weak D type 1, RHD*weak D type 2, RHD*weak D type 3). Weak D samples were distinguishable from partial D in routine typing due to the difference in reactivity of partial D samples with clones D7B8 and RUM-1. Cell line RUM-1 gives weak or negative reactions with partial DVa category. The most common partial D variant in our population is DVa. It is recommended to use cell lines which do not strongly agglutinate DVa variant in routine RhD typing. The appropriate choice of reagents will enable the serology methods to recognize the cases in which RHD genotyping is required. © 2017 Wiley Periodicals, Inc.

Extracts from Lentinula edodes (Shiitake) Edible Mushrooms Enriched with Vitamin D Exert an Anti-Inflammatory Hepatoprotective Effect.

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Drori, Ariel; Shabat, Yehudit; Ben Ya'acov, Ami; Danay, Ofer; Levanon, Dan; Zolotarov, Lidya; Ilan, Yaron

2016-04-01

Vitamin D has been known for its anti-inflammatory properties. Extracts derived from Lentinula edodes (Shiitake) edible mushroom exert an anti-inflammatory effect. These extracts contain high levels of ergosterol, which converts into ergocalciferol (vitamin D2) following exposure to ultraviolet light, followed by absorption and hydroxylation into the active form 25-hydroxyvitamin D [25(OH)D]. To determine the anti-inflammatory effect of overexpression of vitamin D in edible mushrooms, L. edodes mushrooms were exposed to ultraviolet-B light, freeze-dried, followed by measurement of vitamin D2 contents, in their dry weight. C57B1/6 mice were orally treated with vitamin D2-enriched or nonenriched mushroom extract prior and during concanavalin A-immune-mediated liver injury. Exposure to ultraviolet light increased vitamin D2 content in Shiitake edible mushrooms. Following feeding of vitamin D-enriched mushroom extracts to mice with immune-mediated hepatitis, a significant decrease in liver damage was noted. This was shown by a decrease in alanine aminotransferase and aspartate aminotransferase serum levels, a decrease in proportion of mice with severe liver injury, and by improvement in liver histology. These effects were associated with a decrease in serum interferon gamma levels. A synergistic effect was noted between the anti-inflammatory effect of the mushroom extracts and that of vitamin D. Oral administration of vitamin D-enriched L. edodes edible mushroom exerts a synergistic anti-inflammatory effect in the immune-mediated hepatitis. The data support its potential use as safe immunomodulatory adjuvant for the treatment of HCV and nonalcoholic steatohepatitis.

Structure-activity relationships for flavone interactions with amyloid β reveal a novel anti-aggregatory and neuroprotective effect of 2',3',4'-trihydroxyflavone (2-D08).

Science.gov (United States)

Marsh, Dylan T; Das, Sukanya; Ridell, Jessica; Smid, Scott D

2017-07-15

Naturally-occurring flavonoids have well documented anti-aggregatory and neuroprotective properties against the hallmark toxic protein in Alzheimer's disease, amyloid β (Aβ). However the extensive diversity of flavonoids has limited the insight into the precise structure-activity relationships that confer such bioactive properties against the Aβ protein. In the present study we have characterised the Aβ binding properties, anti-aggregatory and neuroprotective effects of a discreet set of flavones, including the recently described novel protein sumoylation inhibitor 2',3',4'-trihydroxyflavone (2-D08). Quercetin, transilitin, jaceosidin, nobiletin and 2-D08 were incubated with human Aβ 1-42 for 48h in vitro and effects on Aβ fibrillisation kinetics and morphology measured using Thioflavin T (ThT) and electron microscopy respectively, in addition to effects on neuronal PC12 cell viability. Of the flavones studied, only quercetin, transilitin and 2-D08 significantly inhibited Aβ 1-42 aggregation and toxicity in PC12 cells. Of those, 2-D08 was the most effective inhibitor. The strong anti-amyloid activity of 2-D08 indicates that extensive hydroxylation in the B ring is the most important determinant of activity against β amyloid within the flavone scaffold. The lack of efficacy of jaceosidin and nobiletin indicate that extension of B ring hydroxylation with methoxyl groups result in an incremental loss of anti-fibrillar and neuroprotective activity, highlighting the constraint to vicinal hydroxyl groups in the B ring for effective inhibition of aggregation. These findings reveal further structural insights into anti-amyloid bioactivity of flavonoids in addition to a novel and efficacious anti-aggregatory and neuroprotective effect of the semi-synthetic flavone and sumoylation inhibitor 2',3',4'-trihydroxyflavone (2-D08). Such modified flavones may facilitate drug development targeting multiple pathways in neurodegenerative disease. Crown Copyright © 2017

Transgenic Mice Overexpressing Vitamin D Receptor (VDR) Show Anti-Inflammatory Effects in Lung Tissues.

Science.gov (United States)

Ishii, Masaki; Yamaguchi, Yasuhiro; Isumi, Kyoko; Ogawa, Sumito; Akishita, Masahiro

2017-12-01

Vitamin D insufficiency is increasingly recognized as a prevalent problem worldwide, especially in patients with a chronic lung disease. Chronic obstructive pulmonary disease (COPD) is a type of chronic inflammatory lung disease. Previous clinical studies have shown that COPD leads to low vitamin D levels, which further increase the severity of COPD. Vitamin D homeostasis represents one of the most important factors that potentially determine the severity of COPD. Nonetheless, the mechanisms underlying the anti-inflammatory effects of vitamin D receptor (VDR) in lung tissues are still unclear. To investigate the anti-inflammatory effects of VDR, we generated transgenic mice that show lung-specific VDR overexpression under the control of the surfactant protein C promoter (TG mice). The TG mice were used to study the expression patterns of proinflammatory cytokines using real-time polymerase chain reaction and immunohistochemistry. The TG mice had lower levels of T helper 1 (Th1)-related cytokines than wild-type (WT) mice did. No significant differences in the expression of Th2 cytokines were observed between TG and WT mice. This study is the first to achieve lung-specific overexpression of VDR in TG mice: an interesting animal model useful for studying the relation between airway cell inflammation and vitamin D signaling. VDR expression is an important factor that influences anti-inflammatory responses in lung tissues. Our results show the crucial role of VDR in anti-inflammatory effects in lungs; these data are potentially useful for the treatment or prevention of COPD.

Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

Science.gov (United States)

Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

2014-01-01

Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

Photoproduction of charmed D mesons at γ energies of 40-70 GeV

International Nuclear Information System (INIS)

Aston, D.; Atkinson, M.; Bailey, R.; Ball, A.H.; Bouquet, B.; Brookes, G.R.; Broering, J.; Bussey, P.J.; Clarke, D.; Clegg, A.B.

1980-01-01

Inclusive anti D 0 photoproduction is observed in K + π - and K + π - π 0 . Evidence is presented for an associated (C anti D) production mechanism. Cross section estimates and limits are given for anti D and D mesons. (orig.)

Anti-N-methyl-D-aspartate receptor encephalitis with an imaging-invisible ovarian teratoma: a case report.

Science.gov (United States)

Abdul-Rahman, Zainab M; Panegyres, Peter K; Roeck, Margareta; Hawkins, David; Bharath, Jude; Grolman, Paul; Neppe, Cliffe; Palmer, David

2016-10-24

Anti-N-methyl-D-aspartate receptor encephalitis is a recently discovered disease entity of paraneoplastic limbic encephalitis. It largely affects young women and is often associated with an ovarian teratoma. It is a serious yet treatable condition if diagnosed early. Its remedy involves immunotherapy and surgical removal of the teratoma of the ovaries. This case of anti-N-methyl-D-aspartate receptor encephalitis involves an early surgical intervention with bilateral oophorectomy, despite negative imaging evidence of a teratoma. A 25-year-old white woman with anti-N-methyl-D-aspartate receptor encephalitis presented with behavioral changes and seizures that were confirmed to be secondary to anti-N-methyl-D-aspartate receptor encephalitis. She required an admission to our intensive care unit for ventilator support and received a number of immunological therapies. Multiple imaging investigations showed no evidence of an ovarian teratoma; she had a bilateral oophorectomy 29 days after admission. Ovarian histology confirmed the presence of a teratoma with neuronal cells. A few days after the operation she began to show signs of improvement and, apart from mild short-term memory loss, she returned to normal function. Our patient is an example of teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis, in which the teratoma was identified only microscopically. Her case highlights that even with negative imaging evidence of a teratoma, ovarian pathology should still be considered and explored.

Anesthesia in anti-N-methyl-D-aspartate receptor encephalitis - is general anesthesia a requisite? A case report

Directory of Open Access Journals (Sweden)

Sook Hui Chaw

Full Text Available Abstract Anti-N-methyl-D-aspartate receptor encephalitis is a recently described neurological disorder and an increasingly recognized cause of psychosis, movement disorders and autonomic dysfunction. We report 20-year-old Chinese female who presented with generalized tonic-clonic seizures, recent memory loss, visual hallucinations and abnormal behavior. Anti-N-methyl-D-aspartate receptor encephalitis was diagnosed and a computed tomography scan of abdomen reviewed a left adnexal tumor. We describe the first such case report of a patient with anti-N-methyl-D-aspartate receptor encephalitis who was given a bilateral transversus abdominis plane block as the sole anesthetic for removal of ovarian tumor. We also discuss the anesthetic issues associated with anti-N-methyl-D-aspartate receptor encephalitis. As discovery of tumor and its removal is the focus of initial treatment in this group of patients, anesthetists will encounter more such cases in the near future.

Fluorescein isothiocyanate labeled, magnetic nanoparticles conjugated D-penicillamine-anti-metadherin and in vitro evaluation on breast cancer cells

International Nuclear Information System (INIS)

Akca, Ozlet; Unak, Perihan; Medine, E. Ylker; Sakarya, Serhan; Ozdemir, Caglar; Timur, Suna

2011-01-01

Silane modified magnetic nanoparticles were prepared after capped with silica generated from the hydrolyzation of tetraethyl orthosilicate (TEOS). Amino silane (SG-Si900) was added to this solution for surface modification of silica coated magnetic particles. Finally, D-penicillamine (D-PA)-antimetadherin (anti-MTDH) was covalently linked to the amine group using glutaraldehyde as cross-linker. Magnetic nanoparticles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), and atomic force microscopy (AFM). AFM results showed that particles are nearly monodisperse, and the average size of particles was 40 to 50 nm. An amino acid derivative D-PA was conjugated anti-MTDH, which results the increase of uptaking potential of a conjugated agent, labelled fluorescein isothiocyanate (FITC) and then conjugated to the magnetic nanoparticles. In vitro evaluation of the conjugated D-PA-anti-MTDH-FITC to magnetic nanoparticle was studied on MCF-7 breast cancer cell lines. Fluorescence microscopy images of cells after incubation of the sample were obtained to monitor the interaction of the sample with the cancerous cells. Incorporation on cells of FITC labeled and magnetic nanoparticles conjugated D-PA-anti-MTDH was found higher than FITC labeled D-PA-anti-MTDH. The results show that magnetic properties and application of magnetic field increased incorporation rates. The obtained D-PA-anti-MTDH-magnetic nanoparticles-FITC complex has been used for in vitro imaging of breast cancer cells. FITC labeled and magnetic nanoparticles conjugated D-PA-anti-MTDH may be useful as a new class of scintigraphic agents. Results of this study are sufficiently encouraging to bring about further evaluation of this and related compounds for ultraviolet magnetic resonance (UV-MR) dual imaging. (author)

Characterization of the apoptotic response induced by the cyanine dye D112: a potentially selective anti-cancer compound.

Directory of Open Access Journals (Sweden)

Ning Yang

Full Text Available Chemotherapeutic drugs that are used in anti-cancer treatments often cause the death of both cancerous and noncancerous cells. This non-selective toxicity is the root cause of untoward side effects that limits the effectiveness of therapy. In order to improve chemotherapeutic options for cancer patients, there is a need to identify novel compounds with higher discrimination for cancer cells. In the past, methine dyes that increase the sensitivity of photographic emulsions have been investigated for anti-cancer properties. In the 1970's, Kodak Laboratories initiated a screen of approximately 7000 dye structural variants for selective toxicity. Among these, D112 was identified as a promising compound with elevated toxicity against a colon cancer cell line in comparison to a non-transformed cell line. Despite these results changing industry priorities led to a halt in further studies on D112. We decided to revive investigations on D112 and have further characterized D112-induced cellular toxicity. We identified that in response to D112 treatment, the T-cell leukemia cell line Jurkat showed caspase activation, mitochondrial depolarization, and phosphatidylserine externalization, all of which are hallmarks of apoptosis. Chemical inhibition of caspase enzymatic activity and blockade of the mitochondrial pathway through Bcl-2 expression inhibited D112-induced apoptosis. At lower concentrations, D112 induced growth arrest. To gain insight into the molecular mechanism of D112 induced mitochondrial dysfunction, we analyzed the intracellular localization of D112, and found that D112 associated with mitochondria. Interestingly, in the cell lines that we tested, D112 showed increased toxicity toward transformed versus non-transformed cells. Results from this work identify D112 as a potentially interesting molecule warranting further investigation.

[Anesthesia in anti-N-methyl-d-aspartate receptor encephalitis - is general anesthesia a requisite? A case report].

Science.gov (United States)

Chaw, Sook Hui; Foo, Li Lian; Chan, Lucy; Wong, Kang Kwong; Abdullah, Suhailah; Lim, Boon Kiong

Anti-N-methyl-d-aspartate receptor encephalitis is a recently described neurological disorder and an increasingly recognized cause of psychosis, movement disorders and autonomic dysfunction. We report 20-year-old Chinese female who presented with generalized tonic-clonic seizures, recent memory loss, visual hallucinations and abnormal behavior. Anti-N-methyl-d-aspartate receptor encephalitis was diagnosed and a computed tomography scan of abdomen reviewed a left adnexal tumor. We describe the first such case report of a patient with anti-N-methyl-d-aspartate receptor encephalitis who was given a bilateral transversus abdominis plane block as the sole anesthetic for removal of ovarian tumor. We also discuss the anesthetic issues associated with anti-N-methyl-d-aspartate receptor encephalitis. As discovery of tumor and its removal is the focus of initial treatment in this group of patients, anesthetists will encounter more such cases in the near future. Copyright © 2015 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

Color suppressed contributions to the decay modes Bd,s→Ds,dDs,d, Bd,s→Ds,dD*s,d, and Bd,s→D*s,d D*s,d

International Nuclear Information System (INIS)

Eeg, J.O.; Fajfer, S.; Prapotnik, A.

2005-01-01

The amplitudes for decays of the type B d,s →D s,d D s,d , have no factorizable contributions, while B d,s →D s,d D * s,d , and B d,s →D * s,d D * s,d have relatively small factorizable contributions through the annihilation mechanism. The dominant contributions to the decay amplitudes arise from chiral loop contributions and tree level amplitudes which can be obtained in terms of soft gluon emissions forming a gluon condensate. We predict that the branching ratios for the processes anti B 0 d →D s + D s - , anti B 0 d →D s +* D s - and anti B 0 d →D s + D s -* are all of order (2-3) x 10 -4 , while anti B 0 s →D d + D d - , anti B 0 s →D d +* D d - and anti B 0 s →D d + D d -* are of order (4-7) x 10 -3 . We obtain branching ratios for two D * 's in the final state of order two times bigger. (orig.)

Risques dus aux résidus d'antibiotiques détectés dans le lait de ...

African Journals Online (AJOL)

SARAH

31 août 2014 ... Mots clés : résidus d'antibiotique, lait cru, bovin, risque, Bénin. Journal of Applied Biosciences 80:7102 – 7112. ISSN 1997–5902 .... cône à usage unique. Les microplaques ainsi apprêtées ont été recouvertes d'un film .... la gestion des pathologies. Toutefois, les faibles pourcentages, inférieurs à 50 % des ...

Atypical presentation of anti-N-methyl-D-aspartate receptor encephalitis: two case reports.

Science.gov (United States)

Maggio, Maria Cristina; Mastrangelo, Greta; Skabar, Aldo; Ventura, Alessandro; Carrozzi, Marco; Santangelo, Giuseppe; Vanadia, Francesca; Corsello, Giovanni; Cimaz, Rolando

2017-08-16

Anti-N-methyl-D-aspartate receptor encephalitis is a rare autoimmune disease characterized by severe neurological and psychiatric symptoms and a difficult diagnosis. The disease is often secondary to a neoplastic lesion, seldom diagnosed years later. Psychiatric symptoms are prevalent in adults; neurologic symptoms are more evident in children, who typically present primarily with neurological symptoms. To the best of our knowledge, the association with juvenile idiopathic arthritis has not been described. We report the cases of two caucasian girls with an atypical presentation. The first patient was an 8-year-old girl with normal psychomotor development. Over a 4-month period she developed behavioral problems, speech impairment, and deterioration in academic skills. Within 8 months from the onset of symptoms, choreic movements gradually appeared. Hematological, neuroradiological, and neurophysiological examinations were negative; however, her symptoms worsened and treatment with prednisone was started. Although her choreic movements improved within 1 month, her neuropsychological and behavioral symptoms continued. Anti-N-methyl-D-aspartate receptor antibodies in cerebrospinal fluid and in blood were detected. Therapy with intravenously administered immunoglobulins was administered, without improvement of symptoms. After 2 months of steroid treatment, she suddenly started to pronounce some words with a progressive improvement in language and behavior. The second patient was a 14-year-old girl with classic anti-N-methyl-D-aspartate receptor encephalitis, treated successfully with intravenously administered immunoglobulins and methylprednisolone, followed by orally administered prednisone, who developed chronic arthritis of the hip. The arthritis was confirmed by magnetic resonance imaging and associated to antinuclear antigen antibody positivity. One year after the encephalitis presentation, an ovarian cystic mass was identified as a teratoma. The surgical resection

Efficacy of D- red blood cell transfusion and rituximab therapy in autoimmune hemolytic anemia with anti-D and panreactive autoantibodies arising after hematopoietic stem cell transplant.

Science.gov (United States)

Minakawa, Keiji; Ohto, Hitoshi; Yasuda, Hiroyasu; Saito, Shunichi; Kawabata, Kinuyo; Ogawa, Kazuei; Nollet, Kenneth E; Ikeda, Kazuhiko

2018-04-17

Autoimmune hemolytic anemia (AIHA) is caused by autoantibodies to red blood cells (RBCs), which can be panreactive and/or specific to Rh/other blood group antigens. We report a severe case of AIHA after bone marrow transplantation (BMT) due to autoanti-D triggered by reactivation of Epstein-Barr virus (EBV) infection. A combined strategy of D- RBC transfusion and administration of anti-CD20 monoclonal antibody (MoAb) resolved the hemolysis. A 33-year-old male underwent allogeneic BMT from an ABO-identical and HLA-matched unrelated male donor. Five months later, while having mild chronic graft-versus-host disease, he manifested AIHA, with a hemoglobin (Hb) level of 5.1 g/dL on AIHA Day 2 (Posttransplant Day 156) and was refractory to D+ RBCs, with a Hb level of 2.4 g/dL on AIHA Day 6. Anti-D-like autoantibodies (titer 1280, subclass immunoglobulin G 1 , monocyte monolayer assay 28.7%) and panreactive (titer 40) were identified. Changing the RBC transfusion strategy to D- increased his Hb level to 6.7 g/dL on Day 10. Administration of anti-CD20 MoAb mitigated EBV-related B-cell proliferation and reduced anti-D autoantibody titer to 320 by Day 16 with normalized Hb concentration after 6 months. In severe AIHA, when standard treatment and regular RBC transfusions are ineffective, transfusion of RBCs lacking the target antigen(s) of autoantibodies and administration of anti-CD20 MoAb should be considered. © 2018 AABB.

Persistent hemolytic disease of the fetus and newborn (HDFN) associated with passive acquisition of anti-D in maternal breast milk.

Science.gov (United States)

Li, Marissa; Blaustein, John C

2017-09-01

Anti-D is a well-documented, significant cause of hemolytic disease of the fetus and newborn (HDFN), but its presence in breast milk is not routinely described. Theoretically, breast milk containing anti-D could have the potential to exacerbate HDFN if ingested by the affected infant. This is a case report of a 28-week premature male neonate with hydrops fetalis born to a 32-year-old woman (gravidity 3/parity 3) with anti-D and anti-G. The male neonate experienced prolonged HDFN due to passive acquisition of anti-D in the mother's breast milk. The mother's breast milk reacted strongly (4+) with the D-positive cells in the antibody screen test. Discontinuation of breast milk feeding and addition of total parenteral nutrition led to the cessation of clinically significant HDFN. Although anti-D is a significant cause of HDFN through placental transfer of antibody, exacerbation of the condition through breast milk antibodies is rarely described. The current case highlights the possibility of this occurring. Discontinuation of maternal breast milk feedings should be considered in infants with HDFN who do not respond to standard treatment. © 2017 AABB.

77 FR 56175 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use)

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2012-09-12

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 573 [Docket No. FDA-2012-F-0949] Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use) AGENCY: Food... 573 Food Additives Permitted in Feed and Drinking Water of Animals (21 CFR part 573) to provide for...

Anti-N-methyl-D-aspartate receptor encephalitis in Taiwan--a comparison between children and adults.

Science.gov (United States)

Lin, Jainn-Jim; Lin, Kuang-Lin; Hsia, Shao-Hsuan; Chou, Min-Liang; Hung, Po-Cheng; Hsieh, Meng-Ying; Chou, I-Jun; Wang, Huei-Shyong

2014-06-01

Since the discovery of antibodies against the N-methyl-D-aspartate receptor in 2007, anti-N-methyl-D-aspartate receptor encephalitis is increasingly recognized worldwide. We compare the clinical features of adults and children with this disorder in Taiwan. Patients admitted to Chang Gung Memorial Hospital and Chang Gung Children's Hospital and those who were referred from other institutions because of unknown encephalitis from 2009 to 2013 were enrolled, and their clinical features were analyzed. Data on cases from a review of the literature were also included in the analysis. Twelve patients (10 females) aged between 7 years and 28 years with anti-N-methyl-D-aspartate receptor encephalitis were identified. Six patients (50%) were Anti-N-methyl-D-aspartate receptor encephalitis is increasingly recognized in Taiwan. It is characterized by its clinical features, predominantly affects females with and/or without an ovarian tumor, and it is a potentially treatable disorder. It is important for neurologists to be familiar with the clinical presentations of the disease in children and young adults. Copyright © 2014 Elsevier Inc. All rights reserved.

In vitro assessment of recombinant, mutant immunoglobulin G anti-D devoid of hemolytic activity for treatment of ongoing hemolytic disease of the fetus and newborn

DEFF Research Database (Denmark)

Nielsen, Leif K; Green, Trine H; Sandlie, Inger

2008-01-01

A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D.......A specific treatment for ongoing hemolytic disease of the fetus and newborn (HDFN) due to anti-D would be very attractive. One approach could be administration to the mother of nonhemolytic anti-D, which by crossing the placenta can block the binding of hemolytic maternal anti-D....

Allergy in patients with anti-N-methyl-d-aspartate receptor encephalitis.

Science.gov (United States)

Jiang, Xin-Yue; Zhang, Le; Jiang, Xian; Abdulaziz, Ammar Taha Abdullah; Wang, Yun-Hui; Li, Jin-Mei; Zhou, Dong

2018-02-01

Allergy is a potential outcome of dysregulated immune system. Previous studies have shown the association of allergy and autoimmune diseases, however, there is few study to investigate the relationship between allergy and anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. Thus, we investigate the rate of allergy in patients with anti-NMDAR encephalitis and analyze the risk factors. The rate of allergy was investigated in patients with anti-NMDAR encephalitis and was compared with patients with virus encephalitis. The clinical cutaneous characters were described in details. All patients with anti-NMDAR encephalitis were divided into allergic and nonallergic group. Clinical factors were compared in the two groups, and logistic regression model was also used to analyze possible risk factors of allergy. Patients with anti-NMDAR encephalitis had a higher rate of allergy than those with viral encephalitis (22.1% vs 9.2%, odds ratio (OR)=3.23, confidence interval (CI)=1.40-7.42, P=0.006). In patients with anti-NMDAR encephalitis, allergic patients exhibited longer days in hospital (30days vs 22days, P=0.005) and higher occurrence of decreased consciousness (81.5% vs 58.9%, P=0.031), higher rate of complications (77.8% vs 57.9%, P=0.046) and abnormal electroencephalography (EEG) (100% vs 78.6%, P=0.021) than patients without allergy. Cerebrospinal fluid (CSF) antibody titers of allergic patients during the disease course were also higher than nonallergic patients (P=0.004). However, further logistic regression analysis did not reveal independent predictors of allergy. Patients with anti-NMDAR encephalitis show higher allergic rate than those with virus encephalitis. Patients with allergy show higher CSF antibody titers and greater illness severity. However, the final outcome of anti-NMDAR encephalitis was not influenced. Copyright © 2017 Elsevier Inc. All rights reserved.

Clinically significant hemolytic disease of the newborn secondary to passive transfer of anti-D from maternal RhIG.

Science.gov (United States)

Cohen, Daniel N; Johnson, Mary S; Liang, Wayne H; McDaniel, Heather L; Young, Pampee P

2014-11-01

RhIG is used worldwide to reduce the incidence of alloimmunization to D during pregnancy. We report a case of clinically significant neonatal hemolysis mediated by maternally administered RhIG. A 25-year-old, O-, primigravid mother with a negative antenatal antibody screen delivered a 6-lb 4-oz, blood group A, D+ baby girl at 36.5 weeks' gestation. Prenatal care included a dose of intramuscular RhIG at 28 weeks' gestation. At delivery, the newborn was markedly jaundiced with a total bilirubin of 6.3 mg/dL, which reached more than 20 mg/dL after 6 days. The newborn's lactate dehydrogenase (LDH) was 485 U/L (normal, newborn's direct antiglobulin test (DAT) was positive for immunoglobulin (Ig)G, with an anti-D identified by elution studies. The possibility of hemolytic disease of the newborn (HDN) due to anti-A was considered, but ultimately ruled out by the absence of anti-A1 in the eluate. The newborn's hyperbilirubinemia was adequately managed with phototherapy. Analysis of the mother's plasma 10 days postpartum revealed an anti-D titer of 8. Two months after birth, the child's laboratory studies, DAT, antibody screen, and peripheral smear were unremarkable. In the context of neonatal anemia, elevated LDH, and reticulocytosis, a positive IgG DAT with anti-D identified in the eluate suggests RhIG-mediated HDN. This appears to be a rarely reported event. © 2014 AABB.

Japanese encephalitis can trigger anti-N-methyl-D-aspartate receptor encephalitis.

Science.gov (United States)

Ma, Jiannan; Zhang, Ting; Jiang, Li

2017-06-01

Japanese encephalitis (JE) is usually a monophasic disease; however, in rare cases, patients with JE may have an early relapse after a partial recovery, giving rise to a biphasic pattern for the disease. In this study, we report three pediatric cases in which post-JE relapse was characterized by movement disorder and/or behavioral problems, and was related to anti-N-methyl-D-aspartate receptor (NMDAR) immunoglobulin G (IgG). Serum and cerebrospinal fluid were examined for anti-NMDAR IgG in three patients who had confirmed JE and then developed relapsing symptoms which were similar to those of anti-NMDAR encephalitis. The main symptoms of the two young children were choreoathetosis, irritability, and sleep disorder; while for the teenager, agitation, mutism, rigidity, and sleep disorder were the main symptoms. Samples of cerebrospinal fluid from all patients were positive for anti-NMDAR IgG, and all patients gradually improved with immunotherapy. Testing for NMDAR antibodies is highly recommend in patients with JE, especially those with a relapsing syndrome involving movement disorder and/or behavioral problems, as these patients may benefit from immunotherapy.

A case of high-titer anti-D hemolytic disease of the newborn in which late onset and mild course is associated with the D variant, RHD-CE(9)-D.

Science.gov (United States)

Jakobsen, Marianne A; Nielsen, Christian; Sprogøe, Ulrik

2014-10-01

The RhD antigen is very immunogenic and is a significant cause of hemolytic disease of the newborn (HDN). The RHD-CE(8-9)-D hybrid allele is commonly associated with a D- phenotype. Here, we report a case of high-titer maternal anti-D and late onset of HDN in a newborn carrying a RHD-CE(9)-D variant supposedly encoding the same partial D antigen as the RHD-CE(8-9)-D allele, but with significant expression of D antigen. To elucidate the blood group antigen background of the case, we carried out serologic, flow cytometric, and genetics studies of the newborn and his father. Individuals carrying the RHD-CE(9)-D allele do express D antigen, but do so at significantly lower levels than those carrying the more common D+ phenotypes (e.g., DCe/dce). It may mitigate and delay otherwise severe HDN in pregnancies complicated by high-titer anti-D. © 2014 AABB.

The Effects of First-Line Anti-Tuberculosis Drugs on the Actions of Vitamin D in Human Macrophages.

Science.gov (United States)

Chesdachai, Supavit; Zughaier, Susu M; Hao, Li; Kempker, Russell R; Blumberg, Henry M; Ziegler, Thomas R; Tangpricha, Vin

2016-12-01

Tuberculosis (TB) is a major global health problem. Patients with TB have a high rate of vitamin D deficiency, both at diagnosis and during the course of treatment with anti-tuberculosis drugs. Although data on the efficacy of vitamin D supplementation on Mycobacterium tuberculosis (Mtb) clearance is uncertain from randomized controlled trials (RCTs), vitamin D enhances the expression of the anti-microbial peptide human cathelicidin (hCAP18) in cultured macrophages in vitro. One possible explanation for the mixed (primarily negative) results of RCTs examining vitamin D treatment in TB infection is that anti-TB drugs given to enrolled subjects may impact actions of vitamin D to enhance cathelicidin in macrophages. To address this hypothesis, human macrophage-like monocytic (THP-1) cells were treated with varying doses of first-line anti-tuberculosis drugs in the presence of the active form of vitamin D, 1N1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ). The expression of hCAP18 was determined by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). 1,25(OH) 2 D 3 strongly induced expression of hCAP18 mRNA in THP-1 cells (fold-change from control). The combination of the standard 4-drug TB therapy (isoniazid, rifampicin, pyrazinamide and ethambutol) in the cultured THP-1 cells demonstrated a significant decrease of hCAP18 mRNA at the dosage of 10 ug/mL. In 31 subjects with newly diagnosed drug-sensitive TB randomized to either high-dose vitamin D 3 (1.2 million IU over 8 weeks, n=13) versus placebo (n=18), there was no change from baseline to week 8 in hCAP18 mRNA levels in peripheral blood mononuclear cells or in plasma concentrations of LL-37, the protein product of hCAP18.These data suggest that first-line anti-TB drugs may alter the vitamin D-dependent increase in hCAP18 and LL-37 human macrophages.

Postpartum Anti-N-methyl-D-aspartate Receptor Encephalitis: A Case Report and Literature Review.

Science.gov (United States)

Doden, Tadashi; Sekijima, Yoshiki; Ikeda, Junji; Ozawa, Kazuki; Ohashi, Nobuhiko; Kodaira, Minori; Hineno, Akiyo; Tachibana, Naoko; Ikeda, Shu-Ichi

2017-01-01

We describe a 24-year-old woman with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis that developed 3 weeks after normal delivery. She was treated with methylprednisolone, intravenous immunoglobulin, and plasmapheresis, in addition to teratoma excision. However, her recovery was slow, and dysmnesia and mental juvenility persisted even two years after onset. To date, five patients with postpartum anti-NMDAR encephalitis have been reported. All of those patients showed psychotic symptoms and were suspected of having postpartum psychosis in the early period of the encephalitis. Changes in hormonal factors, modification of immune tolerance, or retrograde infection of the ovary may be contributing factors for postpartum anti-NMDAR encephalitis.

Bioscience methodologies in physical chemistry an engineering and molecular approach

CERN Document Server

D'Amore, Alberto

2013-01-01

The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

Circulating 25-hydroxy vitamin D correlates with serum level of anti-Müllerian hormone in male patients with chronic kidney disease.

Science.gov (United States)

Abdel Hamid, F F; Soliman, A F; Lashin, F E S

2018-02-14

This study was designed to assess the relationship between serum levels of anti-Müllerian hormone and 25-hydroxy vitamin D in chronic kidney disease male patients. For that, serum 25-hydroxy vitamin D and anti-Müllerian hormone along with follicle-stimulating hormone, luteinising hormone, prolactin, total testosterone and estradiol were assayed in 59 patients with different stages of chronic kidney disease and 21 healthy participants. Compared to controls, serum levels of anti-Müllerian hormone and 25-hydroxy vitamin D were significantly decreased in patients with chronic kidney disease. The decreased anti-Müllerian hormone level correlated positively with estimated glomerular filtration rate and serum levels of testosterone and 25-hydroxy vitamin D. Meanwhile, it was negatively correlated with age and serum levels of urea, creatinine, follicle-stimulating hormone, luteinising hormone and prolactin. 25-Hydroxy vitamin D and luteinising hormone explained the 65.9% variability of anti-Müllerian hormone in a multiple linear regression model. However, anti-Müllerian hormone in crude correlation was more strongly associated with serum 25-hydroxy vitamin D than luteinising hormone. In conclusion, serum level of 25-hydroxy vitamin D might be a determinant factor of anti-Müllerian hormone level, and their relationship might explain in part the dysfunction of Sertoli cells and the impaired testicular functions in chronic kidney disease male patients. © 2018 Blackwell Verlag GmbH.

Course-based undergraduate research experiences in molecular biosciences-patterns, trends, and faculty support.

Science.gov (United States)

Wang, Jack T H

2017-08-15

Inquiry-driven learning, research internships and course-based undergraduate research experiences all represent mechanisms through which educators can engage undergraduate students in scientific research. In life sciences education, the benefits of undergraduate research have been thoroughly evaluated, but limitations in infrastructure and training can prevent widespread uptake of these practices. It is not clear how faculty members can integrate complex laboratory techniques and equipment into their unique context, while finding the time and resources to implement undergraduate research according to best practice guidelines. This review will go through the trends and patterns in inquiry-based undergraduate life science projects with particular emphasis on molecular biosciences-the research-aligned disciplines of biochemistry, molecular cell biology, microbiology, and genomics and bioinformatics. This will provide instructors with an overview of the model organisms, laboratory techniques and research questions that are adaptable for semester-long projects, and serve as starting guidelines for course-based undergraduate research. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (εdA) opposite thymidine in a DNA duplex. Nonplanar alignment of εdA(anti) and dT(anti) at the lesion site

International Nuclear Information System (INIS)

Kouchakdjian, M.; Patel, D.J.; Eisenberg, M.; Yarema, K.; Basu, A.; Essigmann, J.

1991-01-01

Two-dimensional proton NMR studies are reported on the complementary d(C-A-T-G-T-G-T-A-C)·d(G-T-A-C-εA-C-A-T-G) nonanucleotide duplex (designated εdA·dT 9-mer duplex) containing 1,N 6 -ethenodeoxyadenosine (εdA), a carcinogen-DNA adduct, positioned opposite thymidine in the center of the helix. The authors NMR studies have focused on the conformation of the εdA·dT 9-mer duplex at neutral pH with emphasis on defining the alignment at the dT5·εdA14 lesion site. The through-space NOE distance connectivities establish that both dT5 and εdA14 adopt anti glycosidic torsion angles, are directed into the interior of the helix, and stack with flanking Watson-Crick dG4·dC15 and dG6·dC13 pairs. Furthermore, the d(G4-T5-G6)·d(C13-εA14-C15) trinucleotide segment centered about the dT5·εdA14 lesion site adopts a right-handed helical conformation in solution. Energy minimization computations were undertaken starting from six different alignments of dT5(anti) and εdA14(anti) at the lesion site and were guided by distance constraints defined by lower and upper bounds estimated from NOESY data sets on the εdA·dT 9-mer duplex. The NMR data are consistent with a nonplanar alignment of εdA14(anti) and dT5(anti) with dT5 displaced toward the flanking dG4·dC15 base pair within the d(G4-T5-G6)·d(C13-εA14-C15) segment of the εdA·dT 9-mer duplex

Anti-N-methyl-d-aspartate receptor encephalitis in children of Central South China: Clinical features, treatment, influencing factors, and outcomes.

Science.gov (United States)

Wang, Ying; Zhang, Weixi; Yin, Jinghua; Lu, Qianjin; Yin, Fei; He, Fang; Peng, Jing

2017-11-15

We analyzed the clinical manifestations of children with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis in Central South China and the factors influencing the effectiveness of treatment. A retrospective study of children (0-14years old) with anti-NMDAR encephalitis in Central South China was carried out from March 2014 to November 2016. Demographics, clinical features, treatment, outcome, and the factors influencing the effectiveness of treatment were reviewed. Fifty-one patients with anti-NMDAR encephalitis were enrolled (age from 4months to 14years old; median age, 8years; 30 females). Forty-five patients (88%) presented with psychiatric symptoms, 40 (78%) with dyskinesia and movement disorders, 39 (77%) with sleep disturbances, 34 (67%) with seizures, 30 (59%) with a decreased level of consciousness (Glasgow scoreanti-NMDAR encephalitis in Central South China. Patients with decreased consciousness, PICU stay and autonomic instability were more likely to have no or limited response to first-line immunotherapy and to require second-line or even more aggressive immunotherapy. Children with anti-NMDAR encephalitis in China have a much lower incidence of tumors, lower mortality rates, and a lower proportion of lethal autonomic instability than adults. Copyright © 2017 Elsevier B.V. All rights reserved.

3-D Printed Anti-Reflection Structures for the Terahertz Region

Science.gov (United States)

Bomba, Jarosław; Suszek, Jarosław; Makowski, Michał; Sobczyk, Artur; Sypek, Maciej

2018-01-01

Terahertz radiation has a growing number of applications in material characterization, where spectral fingerprinting and diffractive effects are the carriers of information. On the other hand, electromagnetic waves in the range of millimeters exhibit strong unwanted specular reflections, resulting in uncontrolled interferences. This problem is especially disturbing in the goniometric time-domain spectroscopy (TDS) configuration, where angular distribution of the field modified by the sample is altered by unwanted reflections. For this reason, low-cost anti-reflection layers are desired. Here, we present a simple way of designing and manufacturing one-sided and two-sided anti-reflection polyamide layers for the THz range. The structures were fabricated using 3-D printers based on selective laser sintering. We demonstrate experimentally in the goniometric time-domain spectroscopy the significant reduction of wavelength-dependent oscillations in Fabry-Perot configuration in the range between 0.1 and 0.3 THz. We also examine the influence of the anti-reflection layers on the distribution of THz energy in reflected, transmitted, and diffracted fields.

Feasibility study of the anti pp → D{sub s}{sup -}D{sub s0}{sup *}(2317) process with PANDA

Energy Technology Data Exchange (ETDEWEB)

Prencipe, Elisabetta; Gillitzer, Albrecht; Ritman, James [Forschungszentrum Juelich IKP1, Juelich (Germany); Goetzen, Klaus [GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Darmstadt (Germany)

2016-07-01

Charm spectroscopy has recently gained renewed attention, due to confirmations and new observations published by LHCb. Despite of the excellent performance of the CERN experiments, still limitations exist, that do not allow to perform the measurement of the width (Γ) of narrow states with Γ ≤ 1 MeV. The measurement of the D{sub s0}{sup *}(2317) and the D{sub s1}(2460) width is a crucial point to discriminate among theoretical models, and to reveal their nature. One of the major advantage of the future PANDA experiment at FAIR is the excellent momentum beam resolution of about Δp/p=5 x 10{sup -5}, allowing energy scans with an energy resolution down to ΔE ∼ 26 keV. We present a method to measure the width of the D{sub s0}{sup *}(2317), and for the first time a complete full simulation performed with PandaRoot is shown. Feasibility studies for assumption of different signal cross sections are shown, to accommodate the incomplete experimental and theoretical knowledge of the corresponding process of interest. A proposal for a threshold scan for the production reaction anti pp → D{sub s}{sup -}D{sub s0}{sup *}(2317){sup +} in 100-keV-steps is presented, together with an estimate of the competitiveness of PANDA in this field, assuming an average luminosity of L=10{sup 31} cm{sup -1}s{sup -1}.

Color suppressed contributions to the decay modes B{sub d,s}{yields}D{sub s,d}D{sub s,d}, B{sub d,s}{yields}D{sub s,d}D{sup *}{sub s,d}, and B{sub d,s}{yields}D{sup *}{sub s,d} D{sup *}{sub s,d}

Energy Technology Data Exchange (ETDEWEB)

Eeg, J.O. [University of Oslo, Department of Physics, Blindern, Oslo (Norway); Fajfer, S. [University of Ljubljana, Department of Physics, Ljubljana (Slovenia); J. Stefan Institute, Ljubljana (Slovenia); Prapotnik, A. [J. Stefan Institute, Ljubljana (Slovenia)

2005-07-01

The amplitudes for decays of the type B{sub d,s}{yields}D{sub s,d}D{sub s,d}, have no factorizable contributions, while B{sub d,s}{yields}D{sub s,d}D{sup *}{sub s,d}, and B{sub d,s}{yields}D{sup *}{sub s,d}D{sup *}{sub s,d} have relatively small factorizable contributions through the annihilation mechanism. The dominant contributions to the decay amplitudes arise from chiral loop contributions and tree level amplitudes which can be obtained in terms of soft gluon emissions forming a gluon condensate. We predict that the branching ratios for the processes anti B{sup 0}{sub d}{yields}D{sub s}{sup +}D{sub s}{sup -}, anti B{sup 0}{sub d}{yields}D{sub s}{sup +*} D{sub s}{sup -} and anti B{sup 0}{sub d}{yields}D{sub s}{sup +}D{sub s}{sup -*} are all of order (2-3) x 10{sup -4}, while anti B{sup 0}{sub s}{yields}D{sub d}{sup +}D{sub d}{sup -}, anti B{sup 0}{sub s}{yields}D{sub d}{sup +*}D{sub d}{sup -} and anti B{sup 0}{sub s}{yields}D{sub d}{sup +}D{sub d}{sup -*} are of order (4-7) x 10{sup -3}. We obtain branching ratios for two D{sup *}'s in the final state of order two times bigger. (orig.)

Limits on the anomalous ZZγ and Zγγ couplings in p anti p collisions at √s = 1.8 TeV

International Nuclear Information System (INIS)

Abachi, S.

1995-07-01

The authors performed a direct search for the anomalous ZZγ and Zγγ couplings by studying p anti p → ell ell γ + X, (ell = e, μ) events at √s = 1.8 TeV with the D0 detector at the Fermilab Tevatron Collider. A fit to the transverse energy spectrum of the photon in the signal events, based on the data set corresponding to an integrated luminosity of 14.3 pb -1 (13.7 pb -1 ) for the electron (muon) channel, yields the following 95% confidence level limits on the anomalous CP-conserving ZZγ couplings: |h 30 Z | 40 Z = 0), and |h 40 Z | 30 Z = 0), for a form-factor scale Λ = 500 GeV. Limits for the Zγγ couplings and CP-violating couplings are also discussed

Functional in vitro studies of recombinant human immunoglobulin G and immunoglobulin A anti-D

DEFF Research Database (Denmark)

Nielsen, Leif Kofoed; Green, Trine Hefsgaard; Norderhaug, Lars

2007-01-01

The use of anti-D purified from human serum to prevent hemolytic disease of the fetus and newborn due to D is well established. Owing to supply and safety reasons, however, an unlimited and non-plasma-derived source of antibodies for Rhesus prophylaxis is needed....

Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Children and Adolescents.

Science.gov (United States)

Scheer, Shelly; John, Rita Marie

2016-01-01

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disease that is becoming increasingly recognized in the pediatric population. It may be the most common cause of treatable autoimmune encephalitis. The majority of cases of anti-NMDAR encephalitis are idiopathic in etiology, but a significant minority can be attributed to a paraneoplastic origin. Children with anti-NMDAR encephalitis initially present with a prodrome of neuropsychiatric symptoms, often with orofacial dyskinesias followed by progressively worsening seizures, agitation, and spasticity, which may result in severe neurologic deficits and even death. Definitive diagnosis requires detection of NMDAR antibodies in the cerebrospinal fluid. Optimal outcomes are associated with prompt removal of the tumor in paraneoplastic cases, as well as aggressive immunosuppressive therapy. Early detection is essential for increasing the chances for a good outcome. Close follow-up is required to screen for relapse and later onset tumor presentation. The nurse practitioner plays a major role in the research, screening, diagnosis, treatment, follow-up, and rehabilitation of a child or adolescent with anti-NMDAR encephalitis. Copyright © 2016 National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.

Search for Anti-EA(D Antibodies in Subjects with an “Isolated VCA IgG” Pattern

Directory of Open Access Journals (Sweden)

Massimo De Paschale

2010-01-01

Full Text Available The presence of an “isolated viral capsid antigen (VCA IgG” pattern in serum is not easy to interpret without the aid of further tests, such as specific immunoblotting or a virus genome search, that often give rise to organisational and economic problems. However, one alternative is to use an enzyme-linked immunosorbent assay (ELISA to detect anti-early antigen (EA antibodies, which can be found in about 85% of subjects with acute Epstein-Barr virus (EBV infections. The purpose of this work was to search for anti-EA(D antibodies in 130 samples with an isolated VCA IgG pattern at ELISA screening and classified as being indicative of past (102 cases or acute (28 cases infection on the basis of the immunoblotting results. Thirty-seven samples (28.5% were positive for anti-EA(D, of which 25 (89.3% had been classified by immunoblotting as indicating acute and 12 (11.8% past EBV infection. This difference was statistically significant (<.01. The results of our search for anti-EA(D antibodies correctly identified nearly 90% of acute (presence or past EBV infections (absence. When other tests are not available, the search for anti-EA antibodies may therefore be helpful in diagnosing patients with an isolated VCA IgG pattern at screening tests.

Charmed meson rescattering in the reaction anti pd→ anti DDN

International Nuclear Information System (INIS)

Haidenbauer, J.; Krein, G.; Meissner, U.G.; Sibirtsev, A.

2008-01-01

We examine the possibility to extract information about the DN and anti DN interactions from the anti pd→D 0 D - p reaction. We utilize the notion that the open-charm mesons are first produced in the annihilation of the antiproton on one nucleon in the deuteron and subsequently rescatter on the other (the spectator) nucleon. The latter process is then exploited for investigating the DN and anti DN interactions. We study different methods for isolating the contributions from the D 0 p and D - p rescattering terms. (orig.)

Partial wave analysis of anti pp → anti ΛΛ

International Nuclear Information System (INIS)

Bugg, D.V.

2004-01-01

A partial wave analysis of PS185 data for anti pp → anti ΛΛ is presented. A 3 S 1 cusp is identified in the inverse process anti ΛΛ→ anti p p at threshold, using detailed balance to deduce cross sections from anti pp → anti ΛΛ. Partial wave amplitudes for anti pp 3 P 0 , 3 F 3 , 3 D 3 and 3 G 3 exhibit a behaviour very similar to resonances observed in Crystal Barrel data. With this identification, the anti pp → anti ΛΛ data then provide evidence for a new I=0, J PC =1 - resonance with mass M = 2290 ±20 MeV, Γ= 275 ±35 MeV, coupling to both 3 S 1 and 3 D 1 . (orig.)

Possible implications of small or large CP violation in Bd0 vs (anti B)d0→J/ΨKs decay

International Nuclear Information System (INIS)

Xing Zhizhong

2002-01-01

The author argue that a small or large CP-violating asymmetry in B d 0 vs (anti B) d 0 →J/ψK s decays, which seems to be favored by the recent BaBar or Belle data, might hint at the existence of new physics in B d 0 -(anti B) d 0 mixing. The authors present a model-independent framework to show how new physics modifies the standard-model CP-violating asymmetry. The particularly emphasize that the consistent of cp-violating asymmetry experimental result with standard model prediction must not imply the absence of new physics in B d 0 -(anti B) d 0 mixing

The Relevance of Vitamin D and Antinuclear Antibodies in Patients with Inflammatory Bowel Disease Under Anti-TNF Treatment: A Prospective Study.

Science.gov (United States)

Santos-Antunes, João; Nunes, Amadeu Corte-Real; Lopes, Susana; Macedo, Guilherme

2016-05-01

The importance of vitamin D in inflammatory bowel disease (IBD) has been analyzed in former studies, namely concerning the severity of the disease and the efficacy of anti-tumor necrosis factor (TNF) medications. In several inflammatory conditions, biologics have been associated with an autoimmune response with formation of antinuclear antibodies (ANA). In addition, an inverse relationship between vitamin D levels and ANA has been documented. We aimed to evaluate the clinical importance of the link between vitamin D, ANA, and anti-TNF in patients with IBD. Prospective study including patients with IBD with indication to start anti-TNF, between 2009 and 2014. Deficiency and extreme deficiency of vitamin D were defined as levels of 25-hydroxyvitamin D below 20 and 4 ng/mL, respectively. ANA titers were considered positive if higher or equal to 1/100. Among 68 patients (56 with Crohn's Disease, 12 with ulcerative colitis), vitamin D deficiency was detected in 93%. Pretreatment positivity for ANA was related to higher failure rates of anti-TNF treatment (P = 0.008). Pretreatment positivity for ANA and extreme vitamin D deficiency were significant risk factors for adverse events associated with anti-TNF therapy. A significant link was found between extreme deficiency of vitamin D and the presence of ANA. Our study highlights the association between vitamin D deficiency and pretreatment positivity for ANA with the risk for anti-TNF failure and adverse events, and the inverse relationship between vitamin D levels and ANA. Due to the high prevalence of vitamin D deficiency in IBD and the immune-mediated nature of the disease, these elements should be evaluated before starting biologics.

Chiral dynamics, S-wave contributions and angular analysis in D → ππl anti ν

Energy Technology Data Exchange (ETDEWEB)

Shi, Yu-Ji; Wang, Wei; Zhao, Shuai [Shanghai Jiao-Tong University, INPAC, Shanghai Key Laboratory for Particle Physics and Cosmology, Department of Physics and Astronomy, Shanghai (China)

2017-07-15

We present a theoretical analysis of the D{sup -} → π{sup +}π{sup -}l anti ν and anti D{sup 0} → π{sup +}π{sup 0}l anti ν decays. We construct a general angular distribution which can include arbitrary partial waves of ππ. Retaining the S-wave and P-wave contributions we study the branching ratios, forward-backward asymmetries and a few other observables. The P-wave contribution is dominated by ρ{sup 0} resonance, and the S-wave contribution is analyzed using the unitarized chiral perturbation theory. The obtained branching fraction for D → ρlν, at the order 10{sup -3}, is consistent with the available experimental data. The S-wave contribution has a branching ratio at the order of 10{sup -4}, and this prediction can be tested by experiments like BESIII and LHCb. Future measurements can also be used to examine the π-π scattering phase shift. (orig.)

La tectonique panafricaine du secteur d’Igherm : implication des dômes extensifs tardi a post-orogeniques (Anti-Atlas Occidental, Maroc

Directory of Open Access Journals (Sweden)

Soulaimani, A.

2005-12-01

Full Text Available L’évolution tectonique tardi-orogénique panafricaine du secteur d’Igherm (Anti-Atlas occidental, Maroc se caractérise par l’exhumation des parties profondes paléoprotérozoïques à l’image des dômes extensifs. Elle est contrôlée par un détachement principal ductile de faible pendage et des détachements de fort pendage de type extensionnel qui succèdent à un raccourcissement régional de direction NW-SE. Le détachement principal subhorizontal, est souligné par des mylonites de faible degré métamorphique. Il sépare deux unités : l’unité inférieure (complexe métamorphique du Paléoprotérozoïque à comportement ductile et l’unité supérieure (Quartzites néoprotérozoïques du Supergroupe de l’Anti-Atlas à comportement fragile. Cette évolution coïncide avec la mise en place des bassins « supradétachement » du Supergroupe de Ouarzazate durant l’extension qui aurait débuté après le raccourcissement panafricain datés vers 650 Ma. L’évènement extensionnel peut être généralisé à tout l’Anti-Atlas occidental.La evolución tectónica tardi-orogénica panafricana del sector de Igherm (Anti-Atlas occidental, Marruecos se caracteriza por la exhumación de las partes profundas proterozoicas como domos extensivos. Está controlada por un despegue principal dúctil con poco buzamiento y despegues con alto buzamiento de tipo extensional que se sobreponen a un acortamiento regional de dirección NO-SE. El despegue principal subhorizontal viene marcado por milonitas con metamorfismo de grado bajo. Este accidente separa dos unidades : la unidad inferior (complejo metamórfico del Paleoproterozoico de comportamiento dúctil y la unidad superior (cuarcitas del neoproterozoico del Supergrupo del Anti-Atlas de comportamiento frágil. Esta evolución coincide con el origen de las cuencas de «supra-detachment» del Supergrupo de Ouarzazate durante la extensión que se habría producido después del acortamiento

Thermoelectric Power Factor Limit of a 1D Nanowire

Science.gov (United States)

Chen, I.-Ju; Burke, Adam; Svilans, Artis; Linke, Heiner; Thelander, Claes

2018-04-01

In the past decade, there has been significant interest in the potentially advantageous thermoelectric properties of one-dimensional (1D) nanowires, but it has been challenging to find high thermoelectric power factors based on 1D effects in practice. Here we point out that there is an upper limit to the thermoelectric power factor of nonballistic 1D nanowires, as a consequence of the recently established quantum bound of thermoelectric power output. We experimentally test this limit in quasiballistic InAs nanowires by extracting the maximum power factor of the first 1D subband through I -V characterization, finding that the measured maximum power factors conform to the theoretical limit. The established limit allows the prediction of the achievable power factor of a specific nanowire material system with 1D electronic transport based on the nanowire dimension and mean free path. The power factor of state-of-the-art semiconductor nanowires with small cross section and high crystal quality can be expected to be highly competitive (on the order of mW /m K2 ) at low temperatures. However, they have no clear advantage over bulk materials at, or above, room temperature.

Exotic tetraquark states with the qq anti Q anti Q configuration

Energy Technology Data Exchange (ETDEWEB)

Luo, Si-Qiang; Chen, Kan; Liu, Xiang [Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Lanzhou University and Institute of Modern Physics, CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Yan-Rui [Shandong University, School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE), Jinan (China); Zhu, Shi-Lin [Peking University, School of Physics and State Key Laboratory of Nuclear Physics and Technology, Beijing (China); Collaborative Innovation Center of Quantum Matter, Beijing (China); Peking University, Center for High Energy Physics, Beijing (China)

2017-10-15

In this work, we study systematically the mass splittings of the qq anti Q anti Q (q = u, d, s and Q = c, b) tetraquark states with the color-magnetic interaction by considering color mixing effects and estimate roughly their masses. We find that the color mixing effect is relatively important for the J{sup P} = 0{sup +} states and possible stable tetraquarks exist in the nn anti Q anti Q (n = u, d) and ns anti Q anti Q systems either with J = 0 or with J = 1. Possible decay patterns of the tetraquarks are briefly discussed. (orig.)

Higher 25-hydroxyvitamin D levels are associated with greater odds of remission with anti-tumour necrosis factor-α medications among patients with inflammatory bowel diseases.

Science.gov (United States)

Winter, R W; Collins, E; Cao, B; Carrellas, M; Crowell, A M; Korzenik, J R

2017-03-01

Vitamin D has been linked to disease activity among patients with inflammatory bowel diseases (IBD). Prior investigation has also suggested that vitamin D levels may affect duration of therapy with anti-tumour necrosis factor-α (anti-TNF-α) medications among patients with IBD. To evaluate the relationship between vitamin D levels and odds of reaching remission while on an anti-TNF-α medication. A total of 521 IBD patients enrolled in the Brigham and Women's IBD Centre database were eligible for inclusion. Patients treated with anti-TNF-α therapy who had vitamin D levels drawn within 6 months prior or 2 weeks after initiation of anti-TNF-α medication and who had reported remission status at 3 months were included. A logistic regression model adjusting for age, gender, IBD diagnosis, anti-TNF-α medication (infliximab vs. adalimumab) and first or subsequent anti-TNF-α medication was used to identify the effect of vitamin D level on initial response to anti-TNF-α therapy. A total of 173 patients were included in the final analysis. On logistic regression, patients with normal vitamin D levels n = 122 at the time of anti-TNF-α medication initiation had a 2.64 increased odds of remission at 3 months compared to patients with low vitamin D levels n = 51 when controlling for age, gender, diagnosis, type of anti-TNF-α medication and first or subsequent anti-TNF-α medication (OR = 2.64, 95% CI = 1.31-5.32, P = 0.0067). These findings suggest that vitamin D levels may influence initial response to anti-TNF-α medication and that low vitamin D levels may pre-dispose patients to decreased odds of remission. © 2017 John Wiley & Sons Ltd.

High dose Intravenous Anti-D Immune Globulin is More Effective and Safe in Indian Paediatric Patients of Immune Thrombocytopenic Purpura.

Science.gov (United States)

Swain, Trupti Rekha; Jena, Rabindra Kumar; Swain, Kali Prasanna

2016-12-01

Immune Thrombocytopenia (ITP) is characterised by an autoimmune antibody-mediated destruction of platelets and impaired platelet production. Few controlled trials exist to guide management of patients with ITP in Indian scenario for which patients require an individualized approach. Anti-D (Rho (D) immune globulin) at a higher dose can prove to be a cost effective and safe alternative for Indian patients with ITP. To compare the safety and efficacy of higher dose (75μg/kg) intravenous Anti-D immune globulin against the standard dose of 50μg/kg for the management of ITP in Indian patients. One hundred and sixty four children with newly diagnosed ITP between 4-14 years were randomly selected for inclusion and were treated with 50μg/kg (standard dose) or 75μg /kg (higher dose) of Anti-D to compare the efficacy and safety of higher dose intravenous anti-D immune globulin. Efficacy of Anti-D was measured in terms of rate of response and median time to response for increase in platelet counts. Any adverse event was noted. A decrease in haemoglobin concentration suggested accompanying haemolysis. Seventy one out of 84 patients treated with Anti-D at 75μg/kg produced complete response (85%) with median time of response being 2.5 days. On the contrary, 45 patients (70%) patients treated with 50μg/kg had complete response. However, there was no significant increase in haemolysis with higher dose. A significant correlation was found between dose and peak increase in platelet count measured at 7 th day following administration. However, there was no relationship between the decrease in haemoglobin and the dose given, or between the increase in platelet count and fall in haemoglobin. A 75μg/kg dose of Anti-D is more effective with acceptable side effect in comparison to 50μg dose for treatment of newly diagnosed Indian patients of ITP.

Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis

Science.gov (United States)

Liu, Cai-yun; Zheng, Xiang-Yu; Ma, Chi

2017-01-01

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is potentially lethal, but it is also a treatable autoimmune disorder characterized by prominent psychiatric and neurologic symptoms. It is often accompanied with teratoma or other neoplasm, especially in female patients. Anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum are characteristic features of the disease, thereby suggesting a pathogenic role in the disease. Here, we summarize recent studies that have clearly documented that both clinical manifestations and the antibodies may contribute to early diagnosis and multidisciplinary care. The clinical course of the disorder is reversible and the relapse could occur in some patients. Anti-NMDAR encephalitis coexisting with demyelinating disorders makes the diagnosis more complex; thus, clinicians should be aware of the overlapping diseases. PMID:28698711

Anti-N-methyl-D-aspartate receptor encephalitis associated with intracranial Angiostrongylus cantonensis infection: a case report.

Science.gov (United States)

Peng, Yu; Liu, Xiaojia; Pan, Suyue; Xie, Zuoshan; Wang, Honghao

2017-04-01

Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a recently described paraneoplastic syndrome with prominent neuropsychiatric symptoms. Many of these cases are associated with neoplasma especially teratoma. In addition, a few of cases with anti-NMDAR antibodies triggered by viral infection have been reported, but never by parasitic infection. Here, we report a novel case of NMDA receptor encephalitis in a 51-year-old male related to the development of anti-NMDAR antibodies triggered by Angiostrongylus cantonensis infection.

Predictions for the anti B0 → anti K*0 X(YZ) and anti Bs0 → φ X(YZ) with X(4160), Y(3940), Z(3930)

International Nuclear Information System (INIS)

Liang, Wei-Hong; Molina, R.; Doering, M.; Xie, Ju-Jun; Oset, E.

2015-01-01

We investigate the decay of anti B 0 → anti K *0 R and anti B s 0 → φR with R being the X(4160), Y(3940), Z(3930) resonances. Under the assumption that these states are dynamically generated from the vector-vector interaction, as has been concluded from several theoretical studies, we use a reaction mechanism of quark production at the elementary level, followed by hadronization of one final q anti q pair into two vectors and posterior final state interaction of this pair of vector mesons to produce the resonances. With this procedure we are able to predict five ratios for these decays, which are closely linked to the dynamical nature of these states, and also predict the order of magnitude of the branching ratios which we find of the order of 10 -4 , well within the present measurable range. In order to further test the dynamical nature of these resonances we study the anti B s 0 → φ D* anti D* and anti B s 0 → φ D s * anti D s * decays close to the D* anti D* and D s * anti D s * thresholds and make predictions for the ratio of the mass distributions in these decays and the anti B s 0 → φR decay widths. The measurement of these decays rates can help unravel the nature of these resonances. (orig.)

Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling

DEFF Research Database (Denmark)

Klewe, Ib V; Nielsen, Søren M; Tarpø, Louise

2008-01-01

, SNPA all acted as partial agonists with decreasing efficacy in the BRET assay. In contrast, a wide selection of typical and atypical anti-psychotics was incapable of stimulating beta-arrestin2 recruitment to the D2 receptor. Moreover, we observed that haloperidol, sertindole, olanzapine, clozapine...

Effect of screening for red cell antibodies, other than anti-D, to detect hemolytic disease of the fetus and newborn: a population study in the Netherlands.

Science.gov (United States)

Koelewijn, J M; Vrijkotte, T G M; van der Schoot, C E; Bonsel, G J; de Haas, M

2008-05-01

Hemolytic disease of the fetus and newborn (HDFN) is a severe disease, resulting from maternal red cell (RBC) alloantibodies directed against fetal RBCs. The effect of a first-trimester antibody screening program on the timely detection of HDFN caused by antibodies other than anti-D was evaluated. Nationwide, all women (1,002 in 305,000 consecutive pregnancies during 18 months) with alloantibodies other than anti-D, detected by a first-trimester antibody screen, were included in a prospective index-cohort study. In a parallel-coverage validation study, patients with HDFN caused by antibodies other than anti-D, that were missed by the screening program, were retrospectively identified. The prevalence of positive antibody screens at first-trimester screening was 1,232 in 100,000; the prevalence of alloantibodies other than anti-D was 328 in 100,000, of which 191 of 100,000 implied a risk for occurrence of HDFN because the father carried the antigen. Overall, severe HDFN, requiring intrauterine or postnatal (exchange) transfusions, occurred in 3.7 percent of fetuses at risk: for anti-K in 11.6 percent; anti-c in 8.5 percent; anti-E in 1.1 percent; Rh antibodies other than anti-c, anti-D, or anti-E in 3.8 percent; and for antibodies other than Rh antibodies or anti-K, in none of the fetuses at risk. All affected children, where antibodies were detected, were promptly treated and healthy at the age of 1 year. The coverage validation study showed a sensitivity of the screening program of 75 percent. Five of 8 missed cases were caused by anti-c, with delay-induced permanent damage in at least 1. First-trimester screening enables timely treatment of HDFN caused by antibodies other than anti-D, however, with a sensitivity of only 75 percent. A second screening at Week 30 of c- women will enhance the screening program. Severe HDFN, caused by antibodies other than anti-D, is associated with anti-K, anti-c, and to a lesser extent with other Rh-alloantibodies.

Routine antenatal anti-D prophylaxis in women who are Rh(D negative: meta-analyses adjusted for differences in study design and quality.

Directory of Open Access Journals (Sweden)

Rebecca M Turner

Full Text Available BACKGROUND: To estimate the effectiveness of routine antenatal anti-D prophylaxis for preventing sensitisation in pregnant Rhesus negative women, and to explore whether this depends on the treatment regimen adopted. METHODS: Ten studies identified in a previous systematic literature search were included. Potential sources of bias were systematically identified using bias checklists, and their impact and uncertainty were quantified using expert opinion. Study results were adjusted for biases and combined, first in a random-effects meta-analysis and then in a random-effects meta-regression analysis. RESULTS: In a conventional meta-analysis, the pooled odds ratio for sensitisation was estimated as 0.25 (95% CI 0.18, 0.36, comparing routine antenatal anti-D prophylaxis to control, with some heterogeneity (I²  =  19%. However, this naïve analysis ignores substantial differences in study quality and design. After adjusting for these, the pooled odds ratio for sensitisation was estimated as 0.31 (95% CI 0.17, 0.56, with no evidence of heterogeneity (I²  =  0%. A meta-regression analysis was performed, which used the data available from the ten anti-D prophylaxis studies to inform us about the relative effectiveness of three licensed treatments. This gave an 83% probability that a dose of 1250 IU at 28 and 34 weeks is most effective and a 76% probability that a single dose of 1500 IU at 28-30 weeks is least effective. CONCLUSION: There is strong evidence for the effectiveness of routine antenatal anti-D prophylaxis for prevention of sensitisation, in support of the policy of offering routine prophylaxis to all non-sensitised pregnant Rhesus negative women. All three licensed dose regimens are expected to be effective.

Utilization of anti-RhD in the emergency department after blunt trauma.

Science.gov (United States)

Thorp, John M

2008-02-01

In the United States, trauma occurs in 6% to 7% of pregnancies. Its severity may range from critical injuries where the mother's life is at risk, to apparently minor injuries, which might not be associated with any worrisome symptoms. One of the risks associated with a traumatic event is fetomaternal hemorrhage--the transfer of fetal blood cells into the maternal circulation. If the maternal blood type is rhesus negative and the fetus is rhesus positive, even a small amount of blood can cause the mother to develop antibodies against the fetal Rho D antigen, thus becoming sensitized. In subsequent pregnancies, this can lead to hemolytic disease of the fetus or newborn, which, if severe, is associated with total body edema, hepatosplenomegaly and heart failure, and intrauterine death. Although there are no published studies specific to the US population, poor awareness of the risk of sensitization following trauma and underutilization of anti-RhD in the emergency department has been reported in countries such as Canada and the United Kingdom. This article reminds caregivers of the risk of rhesus sensitization following blunt trauma, in order that they can administer anti-RhD appropriately and hemolytic disease of the fetus or newborn can be prevented.

Metastable beta limit in DIII-D

International Nuclear Information System (INIS)

La Haye, R.J.; Callen, J.D.; Gianakon, T.A.

1997-06-01

The long-pulse, slowly evolving single-null divertor (SND) discharges in DIII-D with H-mode, ELMs, and sawteeth are found to be limited significantly below (factor of 2) the predicted ideal limit β N = 4l i by the onset of tearing modes. The tearing modes are metastable in that they are explained by the neoclassical bootstrap current (high β θ ) destabilization of a seed island which occurs even if Δ' θ , there is a region of the modified Rutherford equation such that dw/dt > 0 for w larger than a threshold value; the plasma is metastable, awaiting the critical perturbation which is then amplified to the much larger saturated island. Experimental results from a large number of tokamaks indicate that the high beta operational envelope of the tokamak is well defined by ideal magnetohydrodynamic (MHD) theory. The highest beta values achieved have historically been obtained in fairly short pulse discharges, often <1-2 sawteeth periods and < 1-2 energy replacement times. The maximum operational beta in single-null divertor (SND), long-pulse discharges in DIII-D with a cross-sectional shape similar to the proposed ITER tokamak is found to be limited significantly below the threshold for ideal instabilities by the onset of resistive MHD instabilities

Daphne striata Tratt. and D. mezereum L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.

Science.gov (United States)

Tundis, Rosa; Loizzo, Monica R; Bonesi, Marco; Peruzzi, Lorenzo; Efferth, Thomas

2018-02-12

In this study, we investigated for the first time the anti-proliferative and antioxidant properties of D. mezereum and D. striata. The aerial parts were extracted by maceration with n-hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. D. mezereum dichloromethane extract showed a remarkable anti-proliferative with an IC 50 of 6.08 μg/mL against LNCaP cells. Experimental data indicate that Daphne species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.

Charged-Higgs on R_D"_("_*"_), τ polarization, and FBA

International Nuclear Information System (INIS)

Chen, Chuan-Hung; Nomura, Takaaki

2017-01-01

We study the influence of a charged-Higgs on the excess of branching fraction ratio, R_M = BR(anti B → Mτ anti ν_τ)/BR(anti B → Ml anti ν_l) (M = D, D*), in a generic two-Higgs-doublet model. In order to investigate the lepton polarization, the detailed decay amplitudes with lepton helicity are given. When the charged-Higgs is used to resolve excesses, it is found that two independent Yukawa couplings are needed to explain the R_D and R_D_* anomalies. We show that when the upper limit of BR(B_c → τ anti ν_τ) < 30% is included, R_D can be significantly enhanced while R_D_* < 0.27. With the BR(B_c → τ anti ν_τ) constraint, we find that the τ-lepton polarizations can be still affected by the charged-Higgs effects, where the standard model (SM) predictions are obtained: P"τ_D ∼ 0.324 and P"τ_D_* ∼ -0.500, and they can be enhanced to be P"τ_D ∼ 0.5 and P"τ_D_* ∼ -0.41 by the charged-Higgs. The integrated lepton forward-backward asymmetry (FBA) is also studied, where the SM result is anti A"D""(""*"")","τ_F_B ∼ -0.359(0.064), and they can be enhanced (decreased) to be anti A"D""(""*"")","τ_F_B ∼ -0.33(0.02). (orig.)

Division of Energy Biosciences annual report and summaries of FY 1996 activities

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-04-01

The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.

Free massless fermionic fields of arbitrary spin in d-dimensional anti-de Sitter space

Energy Technology Data Exchange (ETDEWEB)

Vasiliev, M A

1988-04-25

Free massless fermionic fields of arbitrary spins, corresponding to fully symmetric tensor-spinor irreducible representations of the flat little group SO(d-2), are described in d-dimensional anti-de Sitter space in terms of differential forms. Appropriate linearized higher-spin curvature 2-forms are found. Explicitly gauge invariant higher-spin actions are constructed in terms of these linearized curvatures.

Une plateforme pour la mise au point d'un vaccin anti-adénovirus ...

International Development Research Centre (IDRC) Digital Library (Canada)

Une plateforme pour la mise au point d'un vaccin anti-adénovirus non réplicatif contre les maladies aviaires. 09 avril 2018. Fonds d'innovation en vaccins pour le bétail. Photo: Sven Torfinn/Panos Pictures. La volaille constitue un élevage essentiel en Afrique subsaharienne, surtout pour la sécurité alimentaire et ...

Reconstruction of B- → D*0e- anti νe decays and determination of vertical stroke Vcb vertical stroke

International Nuclear Information System (INIS)

Schubert, J.

2006-01-01

In this analysis the decay B - → D *0 e - anti ν e is measured. The underlying data sample consists of about 226 million B anti B-pairs accumulated on the Υ(4S) resonance by the BABAR detector at the asymmetric e + e - collider PEP-II. The reconstruction of the decay uses the channels D *0 → D 0 π 0 , D 0 → K - π + and π 0 → γγ. The neutrino is not reconstructed. Since the rest frame of the B meson is unknown, the boost w of the D *0 meson in the B meson rest frame is estimated by w. The w spectrum of the data is described in terms of the partial decay width dΓ/dw given by theory and the detector simulation translating each spectrum dΓ/dw into an expectation of the measured w spectrum. dΓ/dw depends on a form factor F(w) parameterizing the strong interaction in the decay process. To find the best descriptive dΓ/dw a fit to the data determines the following two parameters of dΓ/dw: (i) F(1) vertical stroke V cb vertical stroke, the product between F at zero D *0 -recoil and the CKM matrix element vertical stroke V cb vertical stroke; (ii) ρ 2 A1 , a parameter of the form factor F(w). The former parameter scales the height of dΓ/dw and ρ 2 A1 varies the shape of it. The determined values of F(1) vertical stroke V cb vertical stroke, ρ 2 A1 and B(B - → D *0 e - anti ν e ) are F(1) vertical stroke V cb vertical stroke =(35.8±0.5±1.5) x 10 -3 , ρ 2 A1 =(1.08±0.05±0.09) and B(B - → D *0 e - anti ν e )=(5.60±0.08±0.42)%, where the uncertainties are statistical and systematic, respectively. The values of B(B - → D *0 e - anti ν e ) has been determined by an integration of dΓ/dw over the allowed w range using the fitted values of F(1) vertical stroke V cb vertical stroke and ρ 2 A1 . (orig.)

Environmental Biosciences Program Third Quarter Report

Energy Technology Data Exchange (ETDEWEB)

Lawrence C. Mohr, M.D.

2003-01-31

In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

Environmental Biosciences Program Fourth Quarter Report

Energy Technology Data Exchange (ETDEWEB)

Lawrence C. Mohr, M.d.

2003-04-30

In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

Second Quarter Report Environmental Biosciences Program

Energy Technology Data Exchange (ETDEWEB)

Lawrence C. Mohr, M.D.

2002-10-31

In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

Extremal limits of the C metric: Nariai, Bertotti-Robinson, and anti-Nariai C metrics

International Nuclear Information System (INIS)

Dias, Oscar J.C.; Lemos, Jose P.S.

2003-01-01

In two previous papers we have analyzed the C metric in a background with a cosmological constant Λ, namely, the de-Sitter (dS) C metric (Λ>0), and the anti-de Sitter (AdS) C metric (Λ 0, Λ=0, and Λ 2 xS-tilde 2 ) to each point in the deformed two-sphere S-tilde 2 corresponds a dS 2 spacetime, except for one point which corresponds to a dS 2 spacetime with an infinite straight strut or string. There are other important new features that appear. One expects that the solutions found in this paper are unstable and decay into a slightly nonextreme black hole pair accelerated by a strut or by strings. Moreover, the Euclidean version of these solutions mediate the quantum process of black hole pair creation that accompanies the decay of the dS and AdS spaces

Anti-inflammatory and anti-cancer activity of mulberry (Morus alba L.) root bark

Science.gov (United States)

2014-01-01

Background Root bark of mulberry (Morus alba L.) has been used in herbal medicine as anti-phlogistic, liver protective, kidney protective, hypotensive, diuretic, anti-cough and analgesic agent. However, the anti-cancer activity and the potential anti-cancer mechanisms of mulberry root bark have not been elucidated. We performed in vitro study to investigate whether mulberry root bark extract (MRBE) shows anti-inflammatory and anti-cancer activity. Methods In anti-inflammatory activity, NO was measured using the griess method. iNOS and proteins regulating NF-κB and ERK1/2 signaling were analyzed by Western blot. In anti-cancer activity, cell growth was measured by MTT assay. Cleaved PARP, ATF3 and cyclin D1 were analyzed by Western blot. Results In anti-inflammatory effect, MRBE blocked NO production via suppressing iNOS over-expression in LPS-stimulated RAW264.7 cells. In addition, MRBE inhibited NF-κB activation through p65 nuclear translocation via blocking IκB-α degradation and ERK1/2 activation via its hyper-phosphorylation. In anti-cancer activity, MRBE deos-dependently induced cell growth arrest and apoptosis in human colorectal cancer cells, SW480. MRBE treatment to SW480 cells activated ATF3 expression and down-regulated cyclin D1 level. We also observed that MRBE-induced ATF3 expression was dependent on ROS and GSK3β. Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS. Conclusions These findings suggest that mulberry root bark exerts anti-inflammatory and anti-cancer activity. PMID:24962785

Antioxidant and Anti-aging Activities of Silybum Marianum Protein Hydrolysate in Mice Treated with D-galactose.

Science.gov (United States)

Zhu, Shu Yun; Jiang, Ning; Tu, Jie; Yang, Jing; Zhou, Yue

2017-09-01

In the present study, we investigated the antioxidant and anti-aging effects of Silybum marianum protein hydrolysate (SMPH) in D-galactose-treated mice. D-galactose (500 mg/kg body weight) was intraperitoneally injected daily for 7 weeks to accelerate aging, and SMPH (400, 800, 1,200 mg/kg body weight, respectively) was simultaneously administered orally. The antioxidant and anti-aging effects of SMPH in the liver and brain were measured by biochemical assays. Transmission electron microscopy (TEM) was performed to study the ultrastructure of liver mitochondri. SMPH decreased triglyceride and cholesterol levels in the D-galactose-treated mice. It significantly elevated the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC), which were suppressed by D-galactose. Monoamine oxidase (MAO) and malondialdehyde (MDA) levels as well as the concentrations of caspase-3 and 8-OHdG in the liver and brain were significantly reduced by SMPH. Moreover, it increased Bcl-2 levels in the liver and brain. Furthermore, SMPH significantly attenuated D-galactose-induced liver mitochondrial dysfunction by improving the activities of Na+-K+-ATPase and Ca2+-Mg2+-ATPase as well as mitochondrial membrane potential (ΔΨm) and fluidity. TEM showed that the degree of liver mitochondrial damage was significantly decreased by SMPH. The results indicated that SMPH protects against D-galactose-induced accelerated aging in mice through its antioxidant and anti-aging activities. Copyright © 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.

Stimulated-emission pumping enabling sub-diffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy

NARCIS (Netherlands)

Cleff, C.; Gross, P.; Fallnich, C.; Offerhaus, Herman L.; Herek, Jennifer Lynn; Kruse, K.; Beeker, W.P.; Lee, Christopher James; Boller, Klaus J.

2013-01-01

We present a theoretical investigation of stimulated emission pumping to achieve sub-diffraction-limited spatial resolution in coherent anti-Stokes Raman scattering (CARS) microscopy. A pair of control light fields is used to prepopulate the Raman state involved in the CARS process prior to the CARS

Single-stranded DNA aptamer targeting and neutralization of anti-D alloantibody: a potential therapeutic strategy for haemolytic diseases caused by Rhesus alloantibody.

Science.gov (United States)

Zhang, Yinze; Wu, Fan; Wang, Manni; Zhuang, Naibao; Zhou, Huayou; Xu, Hua

2018-02-01

Rhesus (Rh) D antigen is the most important antigen in the Rh blood group system because of its strong immunogenicity. When RhD-negative individuals are exposed to RhD-positive blood, they may produce anti-D alloantibody, potentially resulting in delayed haemolytic transfusion reactions and Rh haemolytic disease of the foetus and newborn, which are difficult to treat. Inhibition of the binding of anti-D antibody with RhD antigens on the surface of red blood cells may effectively prevent immune haemolytic diseases. In this study, single-stranded (ss) DNA aptamers, specifically binding to anti-D antibodies, were selected via systematic evolution of ligands by exponential enrichment (SELEX) technology. After 14 rounds of selection, the purified ssDNA was sequenced using a Personal Genome Machine system. Haemagglutination inhibition assays were performed to screen aptamers for biological activity in terms of blocking antigen-antibody reactions: the affinity and specificity of the aptamers were also determined. In addition to high specificity, the aptamers which were selected showed high affinity for anti-D antibodies with dissociation constant (K d ) values ranging from 51.46±14.90 to 543.30±92.59 nM. By the combined use of specific ssDNA aptamer 7 and auxiliary ssDNA aptamer 2, anti-D could be effectively neutralised at low concentrations of the aptamers. Our results demonstrate that ssDNA aptamers may be a novel, promising strategy for the treatment of delayed haemolytic transfusion reactions and Rh haemolytic disease of the foetus and newborn.