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Sample records for bioscience limited anti-c

  1. Anti-C.Diff Pill

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Anand [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2018-01-30

    The anti- C.diff pill is being developed for patients who are at high risk for Clostridium difficile, a bacterium that causes diarrhea and serious intestinal conditions like colitis. C-diff is deadly, killing over 30,000 people a year in the United States and costing an average of $42,000 per treatment. The most common treatment is a fecal transplant (FT). The anti- C.diff replaces the invasive and messy FT practice with a pill.

  2. C anti c q anti q states

    Energy Technology Data Exchange (ETDEWEB)

    Chao, K T [Oxford Univ. (UK). Dept. of Theoretical Physics; Science Research Council, Chilton (UK). Rutherford and Appleton Labs.)

    1980-07-01

    Taking account of the colour magnetic and electric forces, we discuss the spectroscopy of various types of c anti c q anti q states. Their decay, hadronic production, production in e/sup +/e/sup -/ annihilation as well as photoproduction are also studied.

  3. Sandia National Laboratories: Research: Bioscience

    Science.gov (United States)

    biological agents. We integrate our renowned engineering, nanotechnology, and computational capabilities to Foundations Bioscience Computing & Information Science Electromagnetics Engineering Science Geoscience Opportunities Microsensors Bioscience Leadership Computing and Information Science Engineering Science

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 39; Issue 5. Evolution and expression analysis of the soybean glutamate decarboxylase gene family ... Although plant GAD plays important roles in GABA biosynthesis, our knowledge concerning GAD gene family members and their evolutionary relationship remains limited.

  5. Journal of Biosciences

    Indian Academy of Sciences (India)

    Madhu

    The Journal of Biosciences welcomes contributions containing the results of original research in any area of biology. Both brief communications (within 4 typed pages or 1500 words of text) and full-length articles are accepted. There are no page charges for printing colour photographs. Fifty reprints will be supplied free of ...

  6. Journal of Applied Biosciences

    African Journals Online (AJOL)

    The Journal of Applied Biosciences provides a forum for scholars and practitioners in all spheres of biological sciences to publish their research findings or theoretical concepts and ideas of a scientific nature. Other websites related to this journal: http://m.elewa.org/Journals/about-jab/ ...

  7. Anti-C1q antibodies in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Orbai, A-M; Truedsson, L; Sturfelt, G

    2015-01-01

    OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information...... in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis....

  8. Bioscience, bioinnovations, and bioethics.

    Science.gov (United States)

    Leisola, Matti

    2007-01-01

    Biosciences and their applications, which we call biotechnology, have affected human society in many ways. Great hopes have been set on future biotechnology. The future depends on three key issues. First, we need good science. Recent developments in biosciences have surprised us in many ways. I shall explain in this article how. Secondly, we need structured innovation systems in order to commercialize our discoveries. Europe is slow in this respect compared to our Japanese and American competitors and may lose in the competition. I shall describe the Finnish innovation chain using the rewarded Otaniemi model as an example of how commercialization can be done in a systematic way. Thirdly, we need norms to guide what to do and where to go. Bioethics is probably the most neglected of the three key issues. With modern biotechnology we are able to do things that should worry every citizen, but the ethical discussion has been largely neglected or the discussion in our pluralistic society is leading nowhere. I shall finally discuss these problems from a historical perspective.

  9. Has bioscience reconciled mind and body?

    Science.gov (United States)

    Davies, Carmel; Redmond, Catherine; Toole, Sinead O; Coughlan, Barbara

    2016-09-01

    The aim of this discursive paper is to explore the question 'has biological science reconciled mind and body?'. This paper has been inspired by the recognition that bioscience has a historical reputation for privileging the body over the mind. The disregard for the mind (emotions and behaviour) cast bioscience within a 'mind-body problem' paradigm. It has also led to inherent limitations in its capacity to contribute to understanding the complex nature of health. This is a discursive paper. Literature from the history and sociology of science and psychoneuroimmunology (1975-2015) inform the arguments in this paper. The historical and sociological literature provides the basis for a socio-cultural debate on mind-body considerations in science since the 1970s. The psychoneuroimmunology literature draws on mind-body bioscientific theory as a way to demonstrate how science is reconciling mind and body and advancing its understanding of the interconnections between emotions, behaviour and health. Using sociological and biological evidence, this paper demonstrates how bioscience is embracing and advancing its understanding of mind-body interconnectedness. It does this by demonstrating the emotional and behavioural alterations that are caused by two common phenomena; prolonged, chronic peripheral inflammation and prolonged psychological stress. The evidence and arguments provided has global currency that advances understanding of the inter-relationship between emotions, behaviour and health. This paper shows how bioscience has reconciled mind and body. In doing so, it has advanced an understanding of science's contribution to the inter-relationship between emotions, behaviour and health. The biological evidence supporting mind-body science has relevance to clinical practice for nurses and other healthcare professions. This paper discusses how this evidence can inform and enhance clinical practice directly and through research, education and policy. © 2015 John Wiley

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. DALE JAMIESON. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 3-8 Commentary. Liberating primatology · SINDHU RADHAKRISHNA DALE JAMIESON · More Details Abstract Fulltext PDF ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Vidita A Vaidya. Articles written in Journal of Biosciences. Volume 25 Issue 2 June 2000 pp 123-124. Clipboard: Stress, depression and hippocampal damage · Vidita A Vaidya · More Details Fulltext PDF ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Cover page gallery. Cover page gallery. Journal of Biosciences. Cover page. Journal of Biosciences. Current Issue : Vol. 43, Issue 1. Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search ...

  13. Environmental Biosciences Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  14. Hemolytic disease of the newborn- anti c antibody induced hemolysis.

    Science.gov (United States)

    Murki, Srinivas; Kandraju, Hemasree; Devi, Surekha A

    2012-02-01

    Hemolytic disease in the newborn, as a cause of early jaundice, is not uncommon. This is mostly due to Rh (D), ABO incompatibility and rarely due to other minor blood group incompatibility. The authors report two cases of Rh anti c isoimmunization presenting as significant early neonatal jaundice within the 20 h of life. Both the babies were treated with intensive phototherapy. One baby underwent exchange transfusion and the other required packed cell transfusion for anemia.

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. JONAS P RAMOS. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 657-664 Article. In vitro leishmanicidal, antibacterial and antitumour potential of anhydrocochlioquinone A obtained from the fungus Cochliobolus sp. FERNANDA F CAMPOS JONAS ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Chen Fang. Articles written in Journal of Biosciences. Volume 30 Issue 3 June 2005 pp 351-357 Articles. Expression of a ribosome inactivating protein (curcin 2) in Jatropha curcas is induced by stress · Wei Qin Huang Ming-Xing Xu Ying Zhang Xin-Shen Chen Fang · More Details ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Vibha Dwivedi. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 281-297 Articles. Suppression of induced but not developmental apoptosis in Drosophila by Ayurvedic Amalaki Rasayana and Rasa-Sindoor · Vibha Dwivedi Shweta Tiwary Subhash C ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Priyakshi Mahanta. Articles written in Journal of Biosciences. Volume 39 Issue 3 June 2014 pp 351-364 Articles. FUMET: A fuzzy network module extraction technique for gene expression data · Priyakshi Mahanta Hasin Afzal Ahmed Dhruba Kumar Bhattacharyya Ashish Ghosh.

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Kamalvishnu P Gottimukkala. Articles written in Journal of Biosciences. Volume 36 Issue 3 August 2011 pp 461-469 Articles. N-terminal PDZ-like domain of chromatin organizer SATB1 contributes towards its function as transcription regulator · Dimple Notani Praveena L Ramanujam ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. XIAOQIAN DING. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 637-645 Article. MicroRNA-146 protects A549 and H1975 cells from LPS-induced apoptosis and inflammation injury · QIANG WANG DAGANG LI YUQUAN HAN XIAOQIAN DING TAO ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. MASOUD SOLEIMANI. Articles written in Journal of Biosciences. Volume 42 Issue 1 March 2017 pp 23-30 Article. Overexpression of hsa-miR-939 follows by NGFR down-regulation and apoptosis reduction · FAHIMEH HOSSEINI AGHDAEI BAHRAM M SOLTANI SADAT ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Anil K Gupta. Articles written in Journal of Biosciences. Volume 27 Issue 7 December 2002 pp 703-714 Review Article. Applications of inulin and oligofructose in health and nutrition · Narinder Kaur Anil K Gupta · More Details Abstract Fulltext PDF. Inulin and oligofructose belong to a ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. LAXMAN S MEENA. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 149-154 Mini-Review. Triacylglycerol: nourishing molecule in endurance of Mycobacterium tuberculosis · PRATAP C MALI LAXMAN S MEENA · More Details Abstract Fulltext PDF.

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. HIMANI DEY. Articles written in Journal of Biosciences. Volume 42 Issue 2 June 2017 pp 333-344 Review. Regulation of dynamin family proteins by post-translational modifications · USHA P KAR HIMANI DEY ABDUR RAHAMAN · More Details Abstract Fulltext PDF. Dynamin ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Urvashi Bahadur. Articles written in Journal of Biosciences. Volume 26 Issue 1 March 2001 pp 39-46 Articles. Characterization of chicken riboflavin carrier protein gene structure and promoter regulation by estrogen · Nandini Vasudevan Urvashi Bahadur Paturu Kondaiah.

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Journal of Biosciences. Current Issue : Vol. 43, Issue 1 · Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search · Online submission at eBiosciences · Editorial Board · Information for Authors · Subscription ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Sebastian Fettig. Articles written in Journal of Biosciences. Volume 32 Issue 3 April 2007 pp 501-510 Articles. specific and unspecific responses of plants to cold and drought stress · Erwin H Beck Sebastian Fettig Claudia Knake Katja Hartig Tribikram Bhattarai · More Details Abstract ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Carissa Reason. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 389-398 Articles. Declines of seagrasses in a tropical harbour, North Queensland, Australia, are not the result of a single event · Skye McKenna Jessie Jarvis Tonia Sankey Carissa Reason ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. PRASAD A DESHPANDE. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 647-656 Article. IGF1 stimulates differentiation of primary follicles and their growth in ovarian explants of zebrafish ( Danio rerio ) cultured in vitro · PANCHARATNA A KATTI ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Samira Mansour. Articles written in Journal of Biosciences. Volume 38 Issue 4 November 2013 pp 815-823 Review. Casuarina glauca: A model tree for basic research in actinorhizal symbiosis · Chonglu Zhong Samira Mansour Mathish Nambiar-Veetil Didier Bogusz Claudine ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Journal of Biosciences. Current Issue : Vol. 43, Issue 1. Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art · Search · Online submission at eBiosciences · Editorial Board · Information for Authors · Subscription ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Rashmi Chhabra. Articles written in Journal of Biosciences. Volume 28 Issue 1 February 2003 pp 7-11. Effects of exogenous vitamin E supplementation on the levels of oxidants and antioxidants in chronic obstructive pulmonary disease · M K Daga Rashmi Chhabra Bhavneesh ...

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Lidia Andreu Guillo. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 33-39 Articles. TP53 codon 72 polymorphism in pigmentary phenotypes · Kárita Antunes Costa Lidia Andreu Guillo · More Details Abstract Fulltext PDF. The p53 protein exerts different ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Lorena Carro. Articles written in Journal of Biosciences. Volume 38 Issue 4 November 2013 pp 685-693 Articles. Micromonospora is a normal occupant of actinorhizal nodules · Lorena Carro Petar Pujic Martha E Trujillo Phillipe Normand · More Details Abstract Fulltext PDF.

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Odir A Dellagostin. Articles written in Journal of Biosciences. Volume 33 Issue 3 September 2008 pp 355-363 Articles. Purification and molecular cloning of a new galactose-specific lectin from Bauhinia variegata seeds · Luciano S Pinto Celso S Nagano Taianá M Oliveira Tales R ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Shweta Dubey. Articles written in Journal of Biosciences. Volume 31 Issue 5 December 2006 pp 497-501. Clipboard: Putting T cells to sleep: a new paradigm for immune evasion by persistent viruses · Shweta Dubey Shahid Jameel · More Details Fulltext PDF ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Bhagyashri A Shanbhag. Articles written in Journal of Biosciences. Volume 29 Issue 1 March 2004 pp 105-110 Articles. Factors influencing offspring traits in the oviparous multi-clutched lizard, Calotes versicolor (Agamidae) · Rajkumar S Radder Bhagyashri A Shanbhag.

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Pankaj Kumar. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 3-15 Articles. Simple sequence repeats in mycobacterial genomes · Vattipally B Sreenu Pankaj Kumar Javaregowda Nagaraju Hampapathalu A Nagarajaram · More Details Abstract Fulltext ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Rajiv Sarin. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 93-102. Genotype, phenotype and cancer: Role of low penetrance genes and environment in tumour susceptibility · Ashwin Kotnis Rajiv Sarin Rita Mulherkar · More Details Abstract Fulltext ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. S A Ranade. Articles written in Journal of Biosciences. Volume 25 Issue 3 September 2000 pp 291-299 Review articles. Role of polyamines and ethylene as modulators of plant senescence · S Pandey S A Ranade P K Nagar Nikhil Kumar · More Details Abstract Fulltext PDF.

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Journal of Biosciences. Volumes & Issues. Volume 43. Issue 1. Mar 2018. Volume 42. Issue 1. Mar 2017; Issue 2. Jun 2017; Issue 3. Sep 2017; Issue 4. Dec 2017. Volume 41. Issue 1. Mar 2016; Issue 2. Jun 2016; Issue 3. Sep 2016; Issue 4. Dec 2016. Volume 40. Issue 1. Mar 2015 ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Devarshi U Gajjar. Articles written in Journal of Biosciences. Volume 37 Issue 6 December 2012 pp 979-987 Articles. Cx43, ZO-1, alpha-catenin and beta-catenin in cataractous lens epithelial cells · Anshul I Arora Kaid Johar Devarshi U Gajjar Darshini A Ganatra Forum B Kayastha ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Subrata Basu Ray. Articles written in Journal of Biosciences. Volume 26 Issue 5 December 2001 pp 555-559. Commentary: The enigma of morphine tolerance: recent insights · Subrata Basu Ray Shashi Wadhwa · More Details Fulltext PDF. Volume 29 Issue 1 March 2004 pp 51-56 ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Naveen Kumar Nair. Articles written in Journal of Biosciences. Volume 37 Issue 2 June 2012 pp 301-312 Review. Nucleic acids in circulation: Are they harmful to the host? Indraneel Mittra Naveen Kumar Nair Pradyumna Kumar Mishra · More Details Abstract Fulltext PDF. It has been ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Veeraputhiran Subbiah. Articles written in Journal of Biosciences. Volume 33 Issue 2 June 2008 pp 185-193 Articles. Identification of a root-specific glycosyltransferase from Arabidopsis and characterization of its promoter · Virupapuram Vijaybhaskar Veeraputhiran Subbiah Jagreet ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. GEOFFREY BODENHAUSEN. Articles written in Journal of Biosciences. Volume 38 Issue 2 June 2013 pp 189-199. Commentary: On toxic effects of scientific journals · Antoinette Molinié Geoffrey Bodenhausen · More Details Abstract Fulltext PDF. The advent of online publishing ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. ABDUR RAHAMAN. Articles written in Journal of Biosciences. Volume 42 Issue 2 June 2017 pp 333-344 Review. Regulation of dynamin family proteins by post-translational modifications · USHA P KAR HIMANI DEY ABDUR RAHAMAN · More Details Abstract Fulltext PDF. Dynamin ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. A Sahni. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 673-686 Articles. The origin and early evolution of whales: macroevolution documented on the Indian Subcontinent · S Bajpai J G M Thewissen A Sahni · More Details Abstract Fulltext PDF.

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Victor Smetacek. Articles written in Journal of Biosciences. Volume 37 Issue 4 September 2012 pp 589-607 Perspectives. Making sense of ocean biota: How evolution and biodiversity of land organisms differ from that of the plankton · Victor Smetacek · More Details Abstract Fulltext ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Surendra Ghaskadbi. Articles written in Journal of Biosciences. Volume 26 Issue 2 June 2001 pp 153-155 Articles. Hydra constitutively expresses transcripts involved in vertebrate neural differentiation · Sandipan Chatterjee Shweta Lahudkar N N Godbole Surendra Ghaskadbi.

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Tonina Fernandes. Articles written in Journal of Biosciences. Volume 35 Issue 3 September 2010 pp 427-434 Articles. Unusual radioresistance of nitrogen-fixing cultures of Anabaena strains · Harinder Singh Tonina Fernandes Shree Kumar Apte · More Details Abstract Fulltext PDF.

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. PRATAP C MALI. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 149-154 Mini-Review. Triacylglycerol: nourishing molecule in endurance of Mycobacterium tuberculosis · PRATAP C MALI LAXMAN S MEENA · More Details Abstract Fulltext PDF.

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Srinivasan. Articles written in Journal of Biosciences. Volume 27 Issue 1 February 2002 pp 15-25. Comparative genomics using data mining tools · Tannistha Nandi Chandrika B-Rao Srinivasan Ramachandran · More Details Abstract Fulltext PDF. We have analysed the genomes of ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. C SUDHEER KUMAR. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 469-479 Article. Modulation of chaperone-like and membranolytic activities of major horse seminal plasma protein HSP-1/2 by L-carnitine · C SUDHEER KUMAR MUSTI J ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Ardashir K Masouleh. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 829-841 Articles. Application of large-scale sequencing to marker discovery in plants · Robert J Henry Mark Edwards Daniel L E Waters S Gopala Krishnan Peter Bundock Timothy ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. G P Talwar. Articles written in Journal of Biosciences. Volume 30 Issue 4 September 2005 pp 435-447 Perspectives. A destiny to fulfill · G P Talwar · More Details Fulltext PDF. Volume 34 Issue 6 December 2009 pp 909-916 Articles. A partner monoclonal antibody to Moab 730 kills ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Manjula Kalia. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 451-464. Molecular biology and pathogenesis of hepatitis E virus · Vivek Chandra Shikha Taneja Manjula Kalia Shahid Jameel · More Details Abstract Fulltext PDF. The hepatitis E virus ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. L Singh. Articles written in Journal of Biosciences. Volume 36 Issue 4 September 2011 pp 739-748 Review. Mango ginger (Curcuma amada Roxb.) – A promising spice for phytochemicals and biological activities · R S Policegoudra S M Aradhya L Singh · More Details Abstract ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. D Raghunath. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 593-603. Emerging antibiotic resistance in bacteria with special reference to India · D Raghunath · More Details Abstract Fulltext PDF. The antibiotic era started in the 1940s and changed ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Pankaj Verma. Articles written in Journal of Biosciences. Volume 37 Issue 2 June 2012 pp 221-226 Brief communication. Molecular typing of fecal eukaryotic microbiota of human infants and their respective mothers · Prashant K Pandey Jay Siddharth Pankaj Verma Ashish Bavdekar ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Vidya Ramachandran. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 437-464. Epidemiological profile of India: Historical and contemporary perspectives · M D Gupte Vidya Ramachandran R K Mutatkar · More Details Abstract Fulltext PDF.

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. VINCENZO IERARDI. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 623-636 Article. Klebsiella pneumoniae antibiotic resistance identified by atomic force microscopy · VINCENZO IERARDI PAOLO DOMENICHINI SILVIA REALI GIAN MARCO ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Satish K Amarnath. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 539-547. Brucellosis in India – a review · Basappa G Mantur Satish K Amarnath · More Details Abstract Fulltext PDF. Brucellosis is an important re-emerging zoonosis with a ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Xiuhong Yang. Articles written in Journal of Biosciences. Volume 33 Issue 1 March 2008 pp 103-112 Articles. Molecular cloning and characterization of a gene encoding RING zinc finger ankyrin protein from drought-tolerant Artemisia desertorum · Xiuhong Yang Chao Sun Yuanlei ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Finny Monickaraj. Articles written in Journal of Biosciences. Volume 38 Issue 1 March 2013 pp 113-122 Articles. Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes · Finny Monickaraj Sankaramoorthy Aravind Pichamoorthy Nandhini Paramasivam ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. MOHAMMAD HOSSEIN GHAHREMANI. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 555-563 Article. Induction of morphological and functional differentiation of human neuroblastoma cells by miR-124 · SAMANEH SHARIF MOHAMMAD ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Harinder Singh. Articles written in Journal of Biosciences. Volume 35 Issue 3 September 2010 pp 427-434 Articles. Unusual radioresistance of nitrogen-fixing cultures of Anabaena strains · Harinder Singh Tonina Fernandes Shree Kumar Apte · More Details Abstract Fulltext PDF.

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Jacinta S D'souza. Articles written in Journal of Biosciences. Volume 28 Issue 2 March 2003 pp 223-233 Articles. Purification and characterization of a Ca -dependent/calmodulin-stimulated protein kinase from moss chloronema cells · Jacinta S D'souza Man Mohan Johri.

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Ashwin Kotnis. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 93-102. Genotype, phenotype and cancer: Role of low penetrance genes and environment in tumour susceptibility · Ashwin Kotnis Rajiv Sarin Rita Mulherkar · More Details Abstract Fulltext ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. ZAKI ABU RABI. Articles written in Journal of Biosciences. Volume 42 Issue 2 June 2017 pp 265-274 Article. Interleukin 8 in progression of hormone-dependent early breast cancer · JELENA MILOVANOVIĆ NATAŠA TODOROVIĆ-RAKOVIĆ TIJANA VUJASINOVIĆ ZAKI ABU RABI.

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. PAIKE JAYADEVA BHAT. Articles written in Journal of Biosciences. Volume 34 Issue 4 October 2009 pp 513-522 Articles. Epigenetics of the yeast galactose genetic switch · Paike Jayadeva Bhat Revathi S Iyer · More Details Abstract Fulltext PDF. The transcriptional activation of ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Subhash C Lakhotia. Articles written in Journal of Biosciences. Volume 29 Issue 3 September 2004 pp 219-224. Commentary: Epigenetics of heterochromatin · Subhash C Lakhotia · More Details Fulltext PDF. Volume 32 Issue 3 April 2007 pp 429-431. Foreword · Subhash C ...

  13. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Michel Morange. Articles written in Journal of Biosciences. Volume 29 Issue 4 December 2004 pp 378-380. Commentary: The death of Francis Crick: the end of a golden age in biology · Michel Morange · More Details Fulltext PDF. Volume 30 Issue 3 June 2005 pp 313-316 Series.

  14. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. John Bernet. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 249-264 Articles. Viral mimicry of the complement system · John Bernet Jayati Mullick Akhilesh K Singh Arvind Sahu · More Details Abstract Fulltext PDF. The complement system is a potent ...

  16. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. SADHANA SINGH. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 355-364 Articles. Functional and structural abnormalities associated with empathy in patients with schizophrenia: An fMRI and VBM study · Sadhana Singh Shilpi Modi Satnam Goyal ...

  17. Journal of Biosciences | Indian Academy of Sciences

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  18. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Baby P S Chakrapani. Articles written in Journal of Biosciences. Volume 33 Issue 2 June 2008 pp 269-277 Articles. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression · Baby P S ...

  19. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. M Balasubramanyam. Articles written in Journal of Biosciences. Volume 26 Issue 3 September 2001 pp 383-390 Review Article. Orally active insulin mimics: where do we stand now? M Balasubramanyam V Mohan · More Details Abstract Fulltext PDF. The war against diabetes ...

  20. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Naveen Kumar. Articles written in Journal of Biosciences. Volume 32 Issue 5 August 2007 pp 937-945 Articles. ARC: Automated Resource Classifier for agglomerative functional classification of prokaryotic proteins using annotation texts · Muthiah Gnanamani Naveen Kumar ...

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    Home; Journals; Journal of Biosciences. JIANPING SI. Articles written in Journal of Biosciences. Volume 41 Issue 4 December 2016 pp 727-742 ARTICLE. Functional analyses of Populus euphratica brassinosteroid biosynthesis enzyme genes DWF4 (PeDWF4) and CPD (PeCPD) in the regulation of growth and ...

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    Home; Journals; Journal of Biosciences. AA SULTAN. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 531-535 Brief communication. Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India · NP SARMAH K SARMA DR BHATTACHARYYA ...

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    Home; Journals; Journal of Biosciences. Satya Keerthi Kota. Articles written in Journal of Biosciences. Volume 30 Issue 3 June 2005 pp 329-337 Articles. Cloning and characterization of mouse cullin4B/E3 ubiquitin ligase · Rachana Tripathi K Seetharama Satya Keerthi Kota Usha K Srinivas · More Details Abstract Fulltext ...

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    Home; Journals; Journal of Biosciences. BETANIA B COTA. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 657-664 Article. In vitro leishmanicidal, antibacterial and antitumour potential of anhydrocochlioquinone A obtained from the fungus Cochliobolus sp. FERNANDA F CAMPOS JONAS ...

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    Home; Journals; Journal of Biosciences. Anshu Aggarwal. Articles written in Journal of Biosciences. Volume 27 Issue 4 July 2002 pp 339-346 Articles. Place prioritization for biodiversity content · Sahotra Sarkar Anshu Aggarwal Justin Garson Chris R Margules Juliane Zeidler · More Details Abstract Fulltext PDF.

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    Home; Journals; Journal of Biosciences. LI-MIN FENG. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 547-554 Article. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway · LI-MIN FENG XUE-FENG WANG QING-XIAN ...

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    Home; Journals; Journal of Biosciences. P Chauhan. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 729-747 Articles. India at the cross-roads of human evolution · R Patnaik P Chauhan · More Details Abstract Fulltext PDF. The Indian palaeoanthropological record, although patchy at the ...

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    Home; Journals; Journal of Biosciences. Franck Molina. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 145-155 Articles. Formal TCA cycle description based on elementary actions · Pierre Mazière Nicolas Parisey Marie Beurton-Aimar Franck Molina · More Details Abstract Fulltext PDF.

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    Home; Journals; Journal of Biosciences. P Dayanandan. Articles written in Journal of Biosciences. Volume 28 Issue 4 June 2003 pp 455-469 Articles. Structural and histochemical studies on grain-filling in the caryopsis of rice (Oryza sativa L.) S Krishnan P Dayanandan · More Details Abstract Fulltext PDF. The endosperm ...

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  12. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. QING-XIAN HUANG. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 547-554 Article. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway · LI-MIN FENG XUE-FENG WANG ...

  13. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Shobha Rao. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 481-489. Nutritional status of the Indian population · Shobha Rao · More Details Abstract Fulltext PDF. High prevalence of low birth weight, high morbidity and mortality in children and poor ...

  14. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Isaac Salazar-Ciudad. Articles written in Journal of Biosciences. Volume 34 Issue 4 October 2009 pp 573-587 Articles. Looking at the origin of phenotypic variation from pattern formation gene networks · Isaac Salazar-Ciudad · More Details Abstract Fulltext PDF. This article critically ...

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  17. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Gregor Durstewitz. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 821-828 Articles. Large SNP arrays for genotyping in crop plants · Martin W Ganal Andreas Polley Eva-Maria Graner Joerg Plieske Ralf Wieseke Hartmut Luerssen Gregor Durstewitz.

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  19. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. LOCHNER. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 59-74 Article. Thalassiosira mala italic> (Bacillariophyta), a potentially harmful, marine diatom from Chilka Lake and other coastal localities of Odisha, India: Nomenclature, frustule morphology ...

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    Home; Journals; Journal of Biosciences. Niranjan Mishra. Articles written in Journal of Biosciences. Volume 35 Issue 1 March 2010 pp 79-86. Evidence of a humoral immune response against the prokaryotic expressed N-terminal autoprotease (N) protein of bovine viral diarrhoea virus · Niranjan Mishra Katherukamem ...

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    Home; Journals; Journal of Biosciences. Antoinette Molinié. Articles written in Journal of Biosciences. Volume 38 Issue 2 June 2013 pp 189-199. Commentary: On toxic effects of scientific journals · Antoinette Molinié Geoffrey Bodenhausen · More Details Abstract Fulltext PDF. The advent of online publishing greatly ...

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    Home; Journals; Journal of Biosciences. G Keller. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 709-728 Articles. Deccan volcanism, the KT mass extinction and dinosaurs · G Keller A Sahni S Bajpai · More Details Abstract Fulltext PDF. Recent advances in Deccan volcanic studies indicate ...

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    Home; Journals; Journal of Biosciences. Hsinyu Lee. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 157-165 Review. Autophagy: A double-edged sword in Alzheimer's disease · Ying-Tsen Tung Bo-Jeng Wang Ming-Kuan Hu Wen-Ming Hsu Hsinyu Lee Wei-Pang Huang Yung-Feng Liao.

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    Home; Journals; Journal of Biosciences. SUDHANSHU GAUTAM. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 613-621 Article. Small phosphatidate phosphatase ( TtPAH2 ) of Tetrahymena complements respiratory function and not membrane biogenesis function of yeast PAH1.

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    Home; Journals; Journal of Biosciences. Anasuya Majumdar. Articles written in Journal of Biosciences. Volume 30 Issue 4 September 2005 pp 469-474 Articles. Structural organization of the transfer RNA operon I of Vibrio cholerae: Differences between classical and El Tor strains · Atreyi Ghatak Anasuya Majumdar Ranajit ...

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    Home; Journals; Journal of Biosciences. David L Beveridge. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 379-397 Articles. The ABCs of molecular dynamics simulations on B-DNA, circa 2012 · David L Beveridge Thomas E Cheatham III Mihaly Mezei · More Details Abstract Fulltext PDF.

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    Home; Journals; Journal of Biosciences. PRIYANKA BEDI. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 105-115 Article. Root transcripts associated with arsenic accumulation in hyperaccumulator Pteris vittata · RASIKA M POTDUKHE PRIYANKA BEDI BIJAYA K SARANGI RAM A PANDEY ...

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    Home; Journals; Journal of Biosciences. S A Kulasooriya. Articles written in Journal of Biosciences. Volume 31 Issue 5 December 2006 pp 645-650 Reviews. Interactions among endophytic bacteria and fungi: effects and potentials · W M M S Bandara Gamini Seneviratne S A Kulasooriya · More Details Abstract Fulltext PDF.

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    Home; Journals; Journal of Biosciences. A Adaikala Koteswari. Articles written in Journal of Biosciences. Volume 28 Issue 6 December 2003 pp 715-721 Articles. Curcumin-induced inhibition of cellular reactive oxygen species generation: Novel therapeutic implications · M Balasubramanyam A Adaikala Koteswari R ...

  17. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. M T Tanuja. Articles written in Journal of Biosciences. Volume 26 Issue 1 March 2001 pp 71-76 Articles. Incipient sexual isolation in the nasuta-albomicans complex of Drosophila: No-choice experiments · M T Tanuja N B Ramachandra H A Ranganath · More Details Abstract Fulltext ...

  18. Journal of Biosciences | Indian Academy of Sciences

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  19. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Amar J S Klar. Articles written in Journal of Biosciences. Volume 35 Issue 1 March 2010 pp 11-15 Perspectives. A proposal for re-defining the way the aetiology of schizophrenia and bipolar human psychiatric diseases is investigated · Amar J S Klar · More Details Abstract Fulltext ...

  20. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Shree Kumar Apte. Articles written in Journal of Biosciences. Volume 29 Issue 2 June 2004 pp 153-161 Articles. A novel potassium deficiency-induced stimulon in Anabaena torulosa · Anuradha Alahari Shree Kumar Apte · More Details Abstract Fulltext PDF. Potassium deficiency ...

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    Home; Journals; Journal of Biosciences. JAMUNA R SUBRAMANIAM. Articles written in Journal of Biosciences. Volume 41 Issue 4 December 2016 pp 689-695 ARTICLE. Reserpine requires the D2-type receptor, dop-3 , and the exoribonuclease, eri-1 , to extend the lifespan in C. elegans · KOPAL SAHARIA RANJEET ...

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    Home; Journals; Journal of Biosciences. Mihaly Mezei. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 379-397 Articles. The ABCs of molecular dynamics simulations on B-DNA, circa 2012 · David L Beveridge Thomas E Cheatham III Mihaly Mezei · More Details Abstract Fulltext PDF. This article ...

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    Home; Journals; Journal of Biosciences. Ana M soto. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 103-118. Emergentism as a default: Cancer as a problem of tissue organization · Ana M soto Carlos Sonnenschein · More Details Abstract Fulltext PDF. During the last fifty years the dominant ...

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    Home; Journals; Journal of Biosciences. NARAHARI P GRAMAPUROHIT. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 459-468 Article. Can embryonic skipper frogs ( Euphlyctis cyanophlyctis ) learn to recognise kairomones in the absence of a nervous system? SWAPNIL C SUPEKAR ...

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    Home; Journals; Journal of Biosciences. VIDYANAND NANJUNDIAH. Articles written in Journal of Biosciences. Volume 25 Issue 1 March 2000 pp 9-10. Commentary: The smallest form of life yet? Vidyanand Nanjundiah · More Details Fulltext PDF. Volume 28 Issue 6 December 2003 pp 697-707 Articles. Calcium regulates ...

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    Home; Journals; Journal of Biosciences. AMOTZ ZAHAVI. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 49-58 Article. An individual-level selection model for the apparent altruism exhibited by cellular slime moulds · AMOTZ ZAHAVI KEITH D HARRIS VIDYANAND NANJUNDIAH · More Details ...

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    Home; Journals; Journal of Biosciences. Carlos Sonnenschein. Articles written in Journal of Biosciences. Volume 30 Issue 1 February 2005 pp 103-118. Emergentism as a default: Cancer as a problem of tissue organization · Ana M soto Carlos Sonnenschein · More Details Abstract Fulltext PDF. During the last fifty years the ...

  13. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Angelo Martino. Articles written in Journal of Biosciences. Volume 32 Issue 6 September 2007 pp 1207-1212 Review. Sphingosine 1-phosphate as a novel immune regulator of dendritic cells · Angelo Martino · More Details Abstract Fulltext PDF. Although originally described as an ...

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    Home; Journals; Journal of Biosciences. Marta Linde-Medina. Articles written in Journal of Biosciences. Volume 36 Issue 4 September 2011 pp 575-585 Brief communication. Adaptation or exaptation? The case of the human hand · Marta Linde-Medina · More Details Abstract Fulltext PDF. A controversy of relevance to the ...

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    Home; Journals; Journal of Biosciences. Sangappa. Articles written in Journal of Biosciences. Volume 30 Issue 2 March 2005 pp 259-268 Articles. Crystal structure of raw pure Mysore silk fibre based on (Ala-Gly)2-Ser-Gly peptide sequence using Linked-Atom-Least-Squares method · Sangappa S S Mahesh R Somashekar.

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    Home; Journals; Journal of Biosciences. JASWANDI UJWAL DANDEKAR. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 585-601 Article. Fermentative metabolism impedes p53-dependent apoptosis in a Crabtree-positive but not in Crabtree-negative yeast · ABHAY KUMAR JASWANDI ...

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    Home; Journals; Journal of Biosciences. Anurag Kumar Mishra. Articles written in Journal of Biosciences. Volume 27 Issue 3 June 2002 pp 251-259 Articles. Cloning and sequencing of complete -crystallin cDNA from embryonic lens of Crocodylus palustris · Raman Agrawal Reena Chandrashekhar Anurag Kumar Mishra ...

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    Home; Journals; Journal of Biosciences. Indranil Dasgupta. Articles written in Journal of Biosciences. Volume 37 Issue 4 September 2012 pp 791-806 Review. Begomovirus research in India: A critical appraisal and the way ahead · Basanta K Borah Indranil Dasgupta · More Details Abstract Fulltext PDF. Begomoviruses are ...

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    Home; Journals; Journal of Biosciences. R S Sharma. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 391-405. Current status of fertility control methods in India · R S Sharma M Rajalakshmi D Antony Jeyaraj · More Details Abstract Fulltext PDF. Approximately 48.2% of couples of 15 to 49 ...

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    Home; Journals; Journal of Biosciences. SHUGUANG HAN. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 671-681 Article. MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating bone morphogenetic protein 4 · LIANG BAO LEI LV JINPING ...

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    Home; Journals; Journal of Biosciences. Jesper G Sørensen. Articles written in Journal of Biosciences. Volume 29 Issue 4 December 2004 pp 503-511. Ecologically relevant stress resistance: from microarrays and quantitative trait loci to candidate genes – A research plan and preliminary results using Drosophila as a ...

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    Home; Journals; Journal of Biosciences. Scott F Gilbert. Articles written in Journal of Biosciences. Volume 26 Issue 3 September 2001 pp 293-298. Commentary: New vistas for developmental biology · Scott F Gilbert Rocky S Tuan · More Details Fulltext PDF. Volume 27 Issue 5 September 2002 pp 445-446. Commentary: ...

  7. Journal of Biosciences | Indian Academy of Sciences

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    Home; Journals; Journal of Biosciences. Partha P Majumder. Articles written in Journal of Biosciences. Volume 26 Issue 4 November 2001 pp 390a-390a. Preface · Partha P Majumder A Jagannadha Rao · More Details Fulltext PDF. Volume 26 Issue 4 November 2001 pp 533-545. Ethnic populations of India as seen from ...

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    Home; Journals; Journal of Biosciences. XINHUA WANG. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 671-681 Article. MiR-876-5p suppresses epithelial-mesenchymal transition of lung cancer by directly down-regulating bone morphogenetic protein 4 · LIANG BAO LEI LV JINPING ...

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    Home; Journals; Journal of Biosciences. Neeti Sharma. Articles written in Journal of Biosciences. Volume 35 Issue 2 June 2010 pp 187-202 Articles. Spectrum of CREBBP mutations in Indian patients with Rubinstein–Taybi syndrome · Neeti Sharma Avinash M Mali Sharmila A Bapat · More Details Abstract Fulltext PDF.

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Adrian Surmacki. Articles written in Journal of Biosciences. Volume 36 Issue 4 September 2011 pp 691-699 Articles. Differences in predatory pressure on terrestrial snails by birds and mammals · Zuzanna M Rosin Paulina Olborska Adrian Surmacki Piotr Tryjanowski · More Details ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. G V R Prasad. Articles written in Journal of Biosciences. Volume 34 Issue 5 November 2009 pp 649-659 Articles. Divergence time estimates of mammals from molecular clocks and fossils: Relevance of new fossil finds from India · G V R Prasad · More Details Abstract Fulltext PDF.

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. MUNIASAMY NEERATHILINGAM. Articles written in Journal of Biosciences. Volume 41 Issue 3 September 2016 pp 535-561 Review. Application of aptamers in diagnostics, drug-delivery and imaging · CHETAN CHANDOLA SHEETAL KALME MARCO G CASTELEIJN ARTO URTTI ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Q M I Haq. Articles written in Journal of Biosciences. Volume 36 Issue 2 June 2011 pp 329-340 Articles. Mutagenesis in ORF AV2 affects viral replication in Mungbean yellow mosaic India virus · A Rouhibakhsh Q M I Haq V G Malathi · More Details Abstract Fulltext PDF. Mungbean ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. JEDY JOSE. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 363-371 Brief communication. Amalaki Rasayana improved memory and neuronal metabolic activity in AβPP-PS1 mouse model of Alzheimer's disease · VIVEK TIWARI KAMAL SABA ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Girish J Kotwal. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 265-271 Articles. Vaccinia complement control protein: Multi-functional protein and a potential wonder drug · Purushottam Jha Girish J Kotwal · More Details Abstract Fulltext PDF. Vaccinia ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Saqib Mahmood. Articles written in Journal of Biosciences. Volume 40 Issue 3 September 2015 pp 521-530 Articles. Role of leptin G-2548A polymorphism in age- and gender-specific development of obesity · Adeela Shahid Sobia Rana Saqib Mahmood Shahid Saeed · More Details ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. SHUKLA SUSHMITA. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 613-621 Article. Small phosphatidate phosphatase ( TtPAH2 ) of Tetrahymena complements respiratory function and not membrane biogenesis function of yeast PAH1.

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Sinha Sinha. Articles written in Journal of Biosciences. Volume 39 Issue 3 June 2014 pp 525-536 Reviews. Conservation of PHO pathway in ascomycetes and the role of Pho84 · Parul Tomar Sinha Sinha · More Details Abstract Fulltext PDF. In budding yeast, Saccharomyces ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. ANANT B PATEL. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 363-371 Brief communication. Amalaki Rasayana improved memory and neuronal metabolic activity in AβPP-PS1 mouse model of Alzheimer's disease · VIVEK TIWARI KAMAL SABA ...

  1. East Midlands healthcare and bioscience sector strategy

    OpenAIRE

    East Midlands Development Agency

    2007-01-01

    The healthcare and bioscience sector is one of four priority sectors identified in the regional economic strategy, A Flourishing Region. This document sets out a strategy for maximising the contribution of the healthcare and biosciences sector to the economic development of the East Midlands.

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. T Naga Sowjanya. Articles written in Journal of Biosciences. Volume 35 Issue 4 December 2010 pp 539-546 Articles. Translocations used to generate chromosome segment duplications in Neurospora can disrupt genes and create novel open reading frames · Parmit K Singh ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. NILOFER NAQVI. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 127-138 Article. Blocking dephosphorylation at Serine 120 residue in t-SNARE SNAP-23 leads to massive inhibition in exocytosis from mast cells · NASKAR PIEU NILOFER NAQVI NITI ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. SHRUTI D MARATHE. Articles written in Journal of Biosciences. Volume 42 Issue 3 September 2017 pp 481-490 Article. Promoter polymorphism MMP-1 (-1607 2G/1G) and MMP-3 (-1612 5A/6A) in development of HAND and modulation of pathogenesis of HAND · HARI OM SINGH ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. JASMINE M SHAH. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 173-187 Review. Plant reference genes for development and stress response studies · JOYOUS T JOSEPH NAJYA JABEEN POOLAKKALODY JASMINE M SHAH · More Details Abstract ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Pushpa Mittra Bhargava. Articles written in Journal of Biosciences. Volume 34 Issue 2 June 2009 pp 167-168. Commentary: Insufficient regulatory supervision prior to release of genetically modified crops for commercial cultivation in India · Pushpa Mittra Bhargava · More Details ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. PRABHJOT KAUR. Articles written in Journal of Biosciences. Volume 40 Issue 2 June 2015 pp 355-364 Articles. Functional and structural abnormalities associated with empathy in patients with schizophrenia: An fMRI and VBM study · Sadhana Singh Shilpi Modi Satnam Goyal ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Madhuri Thakar. Articles written in Journal of Biosciences. Volume 33 Issue 4 November 2008 pp 515-525. HIV infection in India: Epidemiology, molecular epidemiology and pathogenesis. Samir Lakhashe Madhuri Thakar Sheela Godbole Srikanth Tripathy Ramesh Paranjape.

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. JAMES A NIENOW. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 59-74 Article. Thalassiosira mala italic> (Bacillariophyta), a potentially harmful, marine diatom from Chilka Lake and other coastal localities of Odisha, India: Nomenclature, frustule ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. D BANSAL. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 531-535 Brief communication. Antifolate drug resistance: Novel mutations and haplotype distribution in dhps and dhfr from Northeast India · NP SARMAH K SARMA DR BHATTACHARYYA ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. SHEETAL S NARVEKAR. Articles written in Journal of Biosciences. Volume 42 Issue 4 December 2017 pp 647-656 Article. IGF1 stimulates differentiation of primary follicles and their growth in ovarian explants of zebrafish ( Danio rerio ) cultured in vitro · PANCHARATNA A KATTI ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Antonio G Valdecasas. Articles written in Journal of Biosciences. Volume 34 Issue 6 December 2009 pp 835-843 Perspectives. Understanding complex systems: lessons from Auzoux's and von Hagens's anatomical models · Antonio G Valdecasas Ana M Correas Carmen R Guerrero ...

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. B N Singh. Articles written in Journal of Biosciences. Volume 34 Issue 2 June 2009 pp 263-274 Articles. Variations in morphological and life-history traits under extreme temperatures in Drosophila ananassae · Seema Sisodia B N Singh · More Details Abstract Fulltext PDF.

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Rahul Gaur. Articles written in Journal of Biosciences. Volume 32 Issue 4 June 2007 pp 747-754 Articles. Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block · Rahul Gaur Glenn R Björk Simon Tuck Umesh Varshney.

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Smita Deshpande. Articles written in Journal of Biosciences. Volume 27 Issue 1 February 2002 pp 35-52. Molecular genetics of schizophrenia: past, present and future · Suman Prasad Prachi Semwal Smita Deshpande Triptish Bhatia V L Nimgaonkar B K Thelma · More Details ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. S Ignacimuthu. Articles written in Journal of Biosciences. Volume 31 Issue 3 September 2006 pp 339-345 Articles. Agrobacterium-mediated transformation of chickpea with -amylase inhibitor gene for insect resistance · S Ignacimuthu S Prakash · More Details Abstract Fulltext PDF.

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Vindhya Mohindra. Articles written in Journal of Biosciences. Volume 38 Issue 2 June 2013 pp 373-383 Articles. Physiological responses to acute experimental hypoxia in the air-breathing Indian catfish, Clarias batrachus (Linnaeus, 1758) · Ratnesh Kumar Tripathi Vindhya Mohindra ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Will D Penny. Articles written in Journal of Biosciences. Volume 32 Issue 1 January 2007 pp 129-144 Articles. Dynamic causal models of neural system dynamics: current state and future extensions · Klaas E Stephan Lee M Harrison Stefan J Kiebel Olivier David Will D Penny Karl J ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. STHITAPRANJYA PATI. Articles written in Journal of Biosciences. Volume 43 Issue 1 March 2018 pp 85-95 Article. Acute pharmacogenetic activation of medial prefrontal cortex excitatory neurons regulates anxiety-like behaviour · STHITAPRANJYA PATI ANKIT SOOD SOURISH ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Shikha Srivastava. Articles written in Journal of Biosciences. Volume 37 Issue 1 March 2012 pp 63-72 Articles. High prevalence of oncogenic HPV-16 in cervical smears of asymptomatic women of eastern Uttar Pradesh, India: A population-based study · Shikha Srivastava Sadhana ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Rajkumar S. Articles written in Journal of Biosciences. Volume 29 Issue 1 March 2004 pp 105-110 Articles. Factors influencing offspring traits in the oviparous multi-clutched lizard, Calotes versicolor (Agamidae) · Rajkumar S Radder Bhagyashri A Shanbhag · More Details Abstract ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Gavan Holloway. Articles written in Journal of Biosciences. Volume 28 Issue 3 April 2003 pp 323-335 Articles. HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication · Alison L Greenway Gavan Holloway Dale A McPhee Phoebe Ellis Alyssa ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. K B Saxena. Articles written in Journal of Biosciences. Volume 37 Issue 5 November 2012 pp 811-820 Articles. Advances in genetics and molecular breeding of three legume crops of semi-arid tropics using next-generation sequencing and high-throughput genotyping technologies.

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Vibha Tandon. Articles written in Journal of Biosciences. Volume 37 Issue 3 July 2012 pp 493-502 Articles. Inhibition of HIV-1 Integrase gene expression by 10-23 DNAzyme · Nirpendra Singh Atul Ranjan Souvik Sur Ramesh Chandra Vibha Tandon · More Details Abstract Fulltext ...

  5. Advanced NMR technology for bioscience and biotechnology

    Energy Technology Data Exchange (ETDEWEB)

    Hammel, P.C.; Hernandez, G.; Trewhella, J.; Unkefer, C.J. [Los Alamos National Lab., NM (US); Boumenthal, D.K. [Univ. of Utah, Salt Lake City, UT (US); Kennedy, M.A. [Pacific Northwest National Lab., Richland, WA (US); Moore, G.J. [Wayne State Univ., Detroit, MI (US)

    1998-11-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). NMR plays critical roles in bioscience and biotechnology in both imaging and structure determination. NMR is limited, however, by the inherent low sensitivity of the NMR experiment and the demands for spectral resolution required to study biomolecules. The authors addressed both of these issues by working on the development of NMR force microscopy for molecular imaging, and high field NMR with isotope labeling to overcome limitations in the size of biomolecules that can be studied using NMR. A novel rf coil design for NMR force microscopy was developed that increases the limits of sensitivity in magnetic resonance detection for imaging, and the authors demonstrated sub-surface spatial imaging capabilities. The authors also made advances in the miniaturization of two critical NMR force microscope components. They completed high field NMR and isotope labeling studies of a muscle protein complex which is responsible for regulating muscle contraction and is too large for study using conventional NMR approaches.

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 5 ... Department of Physiology, Kangwon National University School of Medicine, Chuncheon ... Faculty of Applied Marine Science, Cheju National University, Jeju 690-756, Republic ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 1 ... an overview of the implications of such a phenomenon for basic and applied research. ... Department of Crop Biology, Section of Plant Physiology, University of Pisa, Pisa, Italy ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 38; Issue 4 ... Department of Plant Physiology, UPSC, Umeå University, S-90187 Umea, Sweden; Ecologie ... Lyon, France; Faculty of Applied Sciences, Department of Botany, University of Sri ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 4 ... of stochastic differential equation; spectral density; Tchebycheff's inequality ... Estimation of maximum harvesting effort has a great impact on the economics of fisheries and other ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential ... a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types. ... Journal of Biosciences | News ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 2 ... The nucleus accumbens (NAc), a critical structure of the brain reward circuit, is implicated in ... Reduction in the conductance of KIR channels evokes facilitatory effects on EPSPs ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 30; Issue 2 ... From about 6000 brain sub-oesophageal ganglion complexes, the neuropeptide was isolated; and purified ... Radiochemical bioassay confirmed the pheromonotropic effect of the ...

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 33; Issue 1. A songbird forebrain area potentially involved in auditory discrimination and memory formation ... a set of interconnected ascending and descending auditory brain pathways that ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats ... whether chronic aspartame (75 mg/kg) administration could release methanol and induce oxidative stress in the rat brain. ... Journal of Biosciences | News ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Apoptosis; bee; brain; cell division; nervous system ... have a distinct morphology, physiology and behaviour that correlate with their roles in the society and are characterized by some brain polymorphisms. ... Journal of Biosciences | News ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Zinc finger protein 521 is highly expressed in brain, neural stem cells and early ... Fndc5, a precursor of Irisin has inducing effects on the expression level of brain derived neurotrophic factor in hippocampus. ... Journal of Biosciences | News ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Brain; differential proteomics; ICAT; LCM; neuron; tandem mass spectrometry ... but also for gaining valuable understanding into brain function and deciphering proteomics from the workbench to the bedside. ... Journal of Biosciences | News ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Role of sound stimulation in reprogramming brain connectivity. Sraboni Chaudhury Tapas C Nag Suman Jain Shashi Wadhwa ... Keywords. Auditory pathway; avian; brain; sound stimulation; synaptic plasticity ... Journal of Biosciences | News ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains ... determined in different fractions of whole brain after 21 days of treatment. ... Journal of Biosciences | News ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    HPLC analysis reveals the presence of beta amyloid in the OVX and HCL mice brain. Congo red staining analysis revealed the extent of amyloid deposition in OVX and hypercholesterolemia mice brain. ... Journal of Biosciences | News ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay. NATALYA P ... Abstract. The brain-derived neurotrophic factor (BDNF) is a key regulator of neural development and plasticity. ... Journal of Biosciences | News ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    In the same brain areas, VBM results also showed reduced grey and white matter volumes. ... alterations and disturbed functional brain activation during empathy task in persons affected with schizophrenia. ... Journal of Biosciences | News ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster ... operate in neural stem cells during normal brain development and during abnormal brain tumorigenesis. ... Journal of Biosciences | News ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Information for Authors ... Submission of a manuscript will be held to imply that the work reported in it is original, that .... when essential should be numbered consecutively and typed on a separate sheet.

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 4 ... the clusters obtained by a clustering algorithm applied on cancer gene expression data. ... In this context, we have used biochemical pathways, -value statistics of GO attributes, ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 30; Issue 5 ... A genomic library was generated using HindIII and the positive clones were sequenced and ... People's Republic of China; School of Agricultural Science and Technology, Suzhou ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 2 ... (peptides A, B, C, and D) were selected using a phage display 12-mer peptide library. ... School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, Jiangsu 214122, ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 29; Issue 4 ... Plant Biotechnology Research Center, School of Agriculture and Biology, ... D Center, School of Life Sciences, Morgan-Tan International Center for Life Sciences, Fudan University ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 32; Issue 2 ... School of Life Sciences, Morgan-Tan International Center for Life Sciences, Fudan University, ... of China; Plant Biotechnology Research Center, School of Agriculture and Biology, ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 33; Issue 2 ... R & D Center, Morgan-Tan International Center for Life Sciences, Fudan University, ... School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 1 ... and Plant Breeding, University of Agricultural Sciences, Bangalore 560 065, India; Biometrics and Bioinformatics Unit, International Rice Research Institute, Los Banos, Philippines ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 39; Issue 3 ... International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), Patancheru 502 ... Punjab Agricultural University, Ludhiana 141 027, India; RAK College of Agriculture, ...

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 2 ... School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200030, ... D Center, Morgan-Tan International Center for Life Sciences, Fudan University, Shanghai ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 2 ... Department of Horticulture, Agriculture Faculty, Ilam University, Ilam, Iran; Plant Molecular Biology Group, International Centre for Genetic Engineering and Biotechnology, New ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-10-26

    Oct 26, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 5 ... the Early Pleistocene of East Africa, Western Asia and Southeast Asia, thus indirectly ... Centre of Advanced Studies in Geology, Panjab University, Chandigarh ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2007-06-28

    Jun 28, 2007 ... Home; Journals; Journal of Biosciences; Volume 32; Issue 5 ... These methods suffer from disadvantages such as the lack of availability of ... In this work, we have constructed a library of local conformation classes purely ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 35; Issue 1 ... profiling combined with physiological analysis at two time points for soybean seedlings in ... waterlogging through the management of carbohydrate consumption and by regulating ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2011-08-07

    Aug 7, 2011 ... Home; Journals; Journal of Biosciences; Volume 36; Issue 3 ... pathways in animal models of human disease and in patients to provide insights ... progression of metastasis, immune cell trafficking, stem cell therapy, transgenic ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-08-10

    Aug 10, 2009 ... A ubiquitous cue eliciting these plastic phenotypic responses is ... Among the conclusions that emerge from this exploration is the perspective that the plant cell is phenotypically plastic. ... Journal of Biosciences | News ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 41; Issue 3 ... Asthma is a chronic disease due to inflammation of the airways of lungs that is clinically ... ACE insertion/deletion (I/D) polymorphism, rs4646994, in asthma in Pakistani patients.

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 2 ... whole animal was studied after adaptation to low and high concentrations of riboflavin. ... India; Department of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj ...

  2. What is provided and what the registered nurse needs--bioscience learning through the pre-registration curriculum.

    Science.gov (United States)

    Davis, Geraldine M

    2010-11-01

    Registered nurses undertaking programmes of study to become non-medical prescribers appear to have limited biological science knowledge. A case study was undertaken to determine whether the nurses entering Prescriber programmes considered studies in bioscience in their pre-registration nursing courses had been sufficient, linked to practice, and had prepared them for their roles as registered nurses. The literature identifies a continuing trend amongst nursing students describing a lack of sufficient bioscience in initial nurse education; there is limited literature on the views of experienced registered nurses. The participants in this study were 42 registered nurses from adult and mental health nursing, community and inpatient services. The results obtained from questionnaires and interviews are described. Questionnaire analysis identified that 57.1% of participants indicated bioscience in their pre-registration nursing programme had been limited and 40.5% stated the bioscience content had not prepared them for their roles on registration. Those reporting extensive coverage of bioscience were all aged over 41 years and had qualified before 1995. Greatest coverage of bioscience in pre-registration programmes was reported in relation to anatomy and physiology, with relatively limited coverage of microbiology, pharmacology or biochemistry. Respondents considered all five topics to be important. Interviews supported the questionnaire findings. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Branka I Ognjanović. Articles written in Journal of Biosciences. Volume 39 Issue 5 December 2014 pp 859-866 Articles. Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats · Marko D Prokić Milica G Paunović Miloš M Matić Nataša Z Djordjević ...

  4. East Midlands healthcare and bioscience sector strategy appendix 1: healthcare and bioscience res implementation plan

    OpenAIRE

    East Midlands Development Agency

    2007-01-01

    The healthcare and bioscience sector is one of four priority sectors identified in the regional economic strategy, A Flourishing Region. This document sets out the implementation plan for maximising the contribution of the healthcare and biosciences sector to the economic development of the East Midlands.

  5. Correlation of anti C1Q antibodies with disease activity in patients with systemic lupus erythematosus

    International Nuclear Information System (INIS)

    Riaz, M.O.; Ahmed, T.A.

    2016-01-01

    Objective: To study the correlation of anti C1q antibodies with disease activity in patients with systemic lupus erythematosus (SLE). Study Design: Cross sectional, observational study. Place and Duration of study: The Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi in collaboration with Military Hospital, Rawalpindi, Pakistan Institute of Medical Sciences, Islamabad and Benazir Bhutto Hospital, Rawalpindi, from Jan 2012 to Dec 2013. Material and Methods: Patients with a clinical diagnosis of SLE were included in the study on fulfilling revised American College of Rheumatology (ACR) criteria (1997). Main outcome measures were SLE disease activity index (SLEDAI) score and anti C1q antibody levels in serum. SLEDAI scores were calculated for each patient on the basis of physical examination, patient interviews and previous clinical records. Anti C1q antibody levels in the serum were determined by enzyme-linked immunosorbent assay (ELISA) and correlated with the SLEDAI scores by calculating Pearson's correlation coefficient 'r'. The cutoff value for anti C1q antibody positivity in the serum was determined by evaluating the serum levels of anti C1q antibodies in 25 healthy subjects and was 12 U/ml. Results: Six male and forty nine female SLE patients with an age range of 16-47 years (mean 34.5 years) and 8-70 years (mean 31.7 years) respectively were studied. The correlation between anti C1q levels and SLEDAI scores in all patients was demonstrated by calculating the correlation coefficient and was not significant (r=0.19, p=0.14). However, there was an inverse correlation between anti C1q levels and SLEDAI scores in patients with severe disease and this was statistically significant (r=-0.448, p=0.037). The difference in anti C1q antibody positivity between patients with and without nephritis was not significant. The anti C1q antibody levels correlated poorly with anti double stranded deoxyribonucleic acid (dsDNA) antibody positivity. A

  6. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  7. Environmental Biosciences First Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-09-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  8. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  9. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2008-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  10. Approach to a Pregnant Woman with Anti D + Anti C Reactivity Pattern: A Diagnostic Conundrum.

    Science.gov (United States)

    Rai, Preeti; Sharma, Geetika; Singh, Deeksha; Garg, Jyoti

    2017-09-01

    The Rhesus G antigen is present on all RBCs that are C+ and also on most D+ RBCs. Due to this co-distribution of G with either C or D antigen, it mimics a reactivity pattern of anti C + anti D on Indirect Antiglobulin Test (IAT), though the role of Anti G in causing Hemolytic Disease of Newborn (HDN) is controversial. The differentiation of anti D, anti C, and anti G is essential particularly in pregnant females. We hereby report a rare case of anti G with anti D and anti C in a pregnant woman with emphasis on approach to identify anti D+C+G and its implications.

  11. Approach to a Pregnant Woman with Anti D + Anti C Reactivity Pattern: A Diagnostic Conundrum

    OpenAIRE

    Rai, Preeti; Sharma, Geetika; Singh, Deeksha; Garg, Jyoti

    2017-01-01

    The Rhesus G antigen is present on all RBCs that are C+ and also on most D+ RBCs. Due to this co-distribution of G with either C or D antigen, it mimics a reactivity pattern of anti C + anti D on Indirect Antiglobulin Test (IAT), though the role of Anti G in causing Hemolytic Disease of Newborn (HDN) is controversial. The differentiation of anti D, anti C, and anti G is essential particularly in pregnant females. We hereby report a rare case of anti G with anti D and anti C in a pregnant woma...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-08-19

    Aug 19, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 3. What history tells us XVIII. When functional biologists propose mechanisms of evolution. Michel Morange. Series Volume 34 Issue 3 September 2009 pp 373-376. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 5. Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus. Puli Chandramouli Reddy Ishani Sinha Ashwin Kelkar Farhat Habib Saurabh J Pradhan Raman Sukumar Sanjeev ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 3. A rapidly progressing, deadly disease of Actias selene (Indianmoonmoth) larvae associated with a mixed bacterial and baculoviral infection. Marta A Skowron Beata Guzow-Krzemińska Sylwia Barańska Paulina Jędrak Grzegorz Węgrzyn. Articles Volume 40 ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 40; Issue 5. Issue front cover thumbnail. Volume 40, Issue 5. December 2015, pages 829-968. pp 829-832 Series. What history tells us XXXIX. CRISPR-Cas : From a prokaryotic immune system to a universal genome editing tool · Michel Morange · More Details Fulltext PDF.

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 35; Issue 2. Issue front cover thumbnail. Volume 35, Issue 2. June 2010, pages 163-325. pp 163-165. Clipboard: Heat shock protein 90: a capacitor or a mutator? Ritwick Sawarkar Renato Paro · More Details Fulltext PDF. pp 167-169. Clipboard: The small subunit of geranyl ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 43; Issue 2 ... The ErbB signalling pathway has been studied extensively owing to its role in normal physiology ... When applied to drug studies, the efficacy of a drug can be investigated in silico ...

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 27; Issue 4 ... areas, so the data used to make such comparisons should be comparable in quality and quantity. ... data include museums, herbariums and natural resource management agencies. Issues of data precision, accuracy and sampling bias in data sets from such ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 41; Issue 3 .... HUWE1 (the HECT, UBA, and WWE domain-containing protein 1) is an ubiquitin E3 ligase which plays .... pp 487-496 Review ... Galectin-9: From cell biology to complex disease dynamics ... Application of aptamers in diagnostics, drug-delivery and imaging.

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 41; Issue 2. Effects of quercetin on predator stress-related hematological and behavioral alterations in pregnant rats and their offspring. Mohamed ... Keywords. Prenatal stress; Anxiety-like behavior; Memory performance; Hematological analysis; Periadolescence; Quercetin ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 33; Issue 2. Issue front cover thumbnail. Volume 33, Issue 2. June 2008, pages 157-307. pp 157-158. Clipboard: Recovery from amblyopia in adults via decreased visual cortical inhibition caused by experience in an enriched environment · Liisa A Tremere Raphael Pinaud.

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2007-02-09

    Feb 9, 2007 ... Home; Journals; Journal of Biosciences; Volume 32; Issue 2. What history tells us VIII. The progressive construction of a mechanism for prion diseases. Michel Morange. Series Volume 32 Issue 2 March 2007 pp 223-227. Fulltext. Click here to view fulltext PDF. Permanent link:

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-09-04

    Sep 4, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 4. Helicobacter urease: Niche construction at the single molecule level ... Departments of Lifesciences and # Computer Science, School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Punjab, Pakistan ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Logo of the Indian Academy of Sciences ... Home; Journals; Journal of Biosciences; Volume 28; Issue 1 ... Department of Safety and Environmental Management, College of Engineering and Mineral Resources, Morgantown, WV 26506, USA; Health Effects Laboratory Division, National Institute for Occupational Safety and ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2008-12-09

    Dec 9, 2008 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 4. Phenotypic plasticity ... Articles Volume 34 Issue 4 October 2009 pp 605-611 ... Stem cell immortality, vascular autonomy, and epicormic branching are some important features of the phenotypic plasticity of plants that contribute to their longevity.

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, CP 354, 96010-900, Pelotas, RS, Brazil; Faculty of Biosciences and Aquaculture, Bodø University College, NO-8049 Bodø, Norway; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, CP 474, ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 42; Issue 1. What history tells us XLII. A 'new' view of proteins. MICHEL MORANGE. Series Volume 42 Issue 1 March 2017 pp 11-14. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/042/01/0011-0014. Keywords. Allostery ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2008-10-15

    Oct 15, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 4. Combating emerging infectious diseases in India: Orchestrating a symphony. Lalit Kant. Volume 33 Issue 4 November 2008 pp 425-427. Fulltext. Click here to view fulltext PDF. Permanent link:

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 27; Issue 1. Issue front cover thumbnail. Volume 27, Issue 1. February 2002, pages a-70. Genome Analysis. pp a-a. Preface · Alok Bhattacharya · More Details Fulltext PDF. pp 1-6. SWORDS: A statistical tool for analysing large DNA sequences · Probal Chaudhuri Sandip Das.

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Here two very different kinds of organisms are considered: the volvocine algae that become ... that there is a perfect correlation with size: the forms with two cell types are significantly larger than those with one. ... Journal of Biosciences | News ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 42; Issue 3 ... miR-200a-3p have been reported in the brains of Alzheimer'sdisease (AD) patients in recent researches. ... Knockdown of SIRT1 decreased theinhibitory effect of Ab25-35 on cell ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 37; Issue 4. Commentary: Monotremes and marsupials: Comparative models to better understand the function of milk. Sanjana Kuruppath Swathi Bisana Julie A Sharp Christophe Lefevre Satish Kumar Kevin R Nicholas. Volume 37 Issue 4 September 2012 pp 581-588 ...

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 37; Issue 4. Changes in membrane lipids and carotenoids during light acclimation in a marine cyanobacterium Synechococcus sp. Olimpio Montero Alberto Sánchez-Guijo Luis M Lubián Gonzalo Martínez-Rodríguez. Articles Volume 37 Issue 4 September 2012 pp 635-645 ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Issue front cover thumbnail. Volume 31, Issue 2. June 2006, pages 177-292. pp 177-179. Clipboard: Simple laboratory tests of ecological theories: what we can learn from them, and when we should be cautious · Mike S Fowler Lasse Ruokolainen · More Details ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Alok Bhattacharya1. School of Life Sciences and Information Technology, Jawaharlal Nehru University, New Delhi 110 007, India. Journal of Biosciences. Current Issue : Vol. 43, Issue 1 · Current Issue Volume 43 | Issue 1. March 2018. Home · Volumes & Issues · Special Issues · Forthcoming Articles · Gallery of Cover Art ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 41; Issue 2. Toward the 'new century' of handedness in biology: In commemoration of the 100th anniversary of the birth of Francis Crick. Koji Tamura. Clipboard Volume 41 Issue 2 June 2016 pp 169-170 ...

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Home; Journals; Journal of Biosciences; Search ... part of the email address of all email addresses used by the office of Indian Academy of Sciences, including those of the staff, the journals, various programmes, and Current Science, has changed from 'ias.ernet.in' (or 'academy.ias.ernet.in') to 'ias.ac.in'.

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Genetic transformation of peanut (Arachis hypogaea L.) using cotyledonary node as explant and a promoterless gus::nptII fusion gene based vector. T Swathi Anuradha S K Jami R S Datla P B Kirti. Articles Volume 31 Issue 2 June 2006 pp 235-246 ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 26; Issue 4. Is there a role for contraceptive vaccines in fertility control? A Jagannadha Rao. Volume 26 Issue 4 November 2001 pp 425-427. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/026/04/0425-0427. Keywords. Fertility ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 6. A skeletochronological study of growth, longevity, and age at sexual maturity in a population of Rana latastei (Amphibia, Anura). Fabio M Guarino Silvia Lunardi Michela Carlomagno Stefano Mazzotti. Articles Volume 28 Issue 6 December 2003 pp 775-782 ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2011-03-14

    Mar 14, 2011 ... Home; Journals; Journal of Biosciences; Volume 36; Issue 1. Clipboard: New paradigm for ATP synthesis and consumption. C Channakeshava. Volume 36 Issue 1 March 2011 pp 3-4. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/036/01/0003-0004 ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 3. Issue front cover thumbnail. Volume 28, Issue 3. April 2003, pages 248-358. Viral Evasion of Host Responses. pp 248-248. Preface · Shahid Jameel · More Details Fulltext PDF. pp 249-264 Articles. Viral mimicry of the complement system · John Bernet Jayati ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 27; Issue 6. Issue front cover thumbnail. Volume 27, Issue 6. November 2002, pages 552-627. Special Issue on Suppl. 3: The Biology of Entamoeba histolytica. pp 552-552a. Preface · Anuradha Lohia · More Details Fulltext PDF. pp 553-557 Articles.

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-12-09

    Dec 9, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 6 ... and suitable teaching methods have been of great importance in the progress of knowledge. ... And what is valid for the learning of anatomy can be generalized to ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 32; Issue 4. Molecular cloning and expression of the C-terminus of spider flagelliform silk protein from Araneus ventricosus. Kwang Sik Lee Bo Yeon Kim Yeon Ho Je Soo Dong Woo Hung Dae Sohn Byung Rae Jin. Articles Volume 32 Issue 4 June 2007 pp 705-712 ...

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 6. Identification and ... Alignment and phylogenetic analysis indicated that GbAGL2 shared high homology with AG-subfamily genes and belonged to a C-class gene family. DNA gel blot analysis showed that GbAGL2 belonged to a low-copy gene family. Reverse ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 1. P1 peptidase – a mysterious protein of family Potyviridae. Jana Rohožková Milan Navrátil ... The coding region for P1 peptidase is located at the very beginning of the viral genome of the family Potyviridae. Until recently P1 was thought of as serine peptidase with ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 4. RET gene mutations and ... Articles Volume 36 Issue 4 September 2011 pp 603-611 ... Further, 39 family members of seven index cases were analysed, wherein four of the seven index cases showed identical mutations, in 13 of 25 family members. We also ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 2. Splicing ... Articles Volume 36 Issue 2 June 2011 pp 281-287 ... One proband had mutation at the canonical splice site at +5 position of IVS22, and analysis of the transcripts in this family revealed skipping of exon 22 in three members of this family. In one proband ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 2 ... Review Volume 34 Issue 2 June 2009 pp 313-320 ... Matrix metalloproteinases (MMPs) are a family of zinc (Zn)-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and play an important role in ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 42; Issue 1. Diverse roles of WDR5-RbBP5-ASH2L-DPY30 (WRAD) complex in the functions of the SET1 histone methyltransferase family. AAMIR ALI SHWETA TYAGI. Mini-Review Volume 42 Issue 1 ... Keywords. Cell cycle regulation; SET1 family; transcription; WRAD ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-02-24

    Feb 24, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 1. Classical embryology to molecular biology: a personal view of amphibian embryonic development. Horst Grunz. Perspectives Volume 34 Issue 1 March 2009 pp 5-16. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 4. Hypervariable spacer regions are good sites for developing specific PCR-RFLP markers and PCR primers for screening actinorhizal symbionts. Rajani Varghese Vineeta S Chauhan Arvind K Misra. Articles Volume 28 Issue 4 June 2003 pp 437-442 ...

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 33; Issue 1 ... In the present investigation, we evaluated the level of platelet aggregation and ... cirrhosis found in our study is of clinical importance, and the underlying mechanism of such ... Department of Surgical Gastroenterology and Proctology, Stanley Medical College ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 26; Issue 4. Issue front cover thumbnail. Volume 26, Issue 4. November 2001, pages 390a-545. Population of India. pp 390a-390a. Preface · Partha P Majumder A Jagannadha Rao · More Details Fulltext PDF. pp 391-405. Current status of fertility control methods in India.

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 2 .... mapping, expression analysis and polymorphism survey of resistance gene analogues ... However, due to inconsistency in the results of empirical studies, the relationship between FA and ... MMP-1 polymorphism and its relationship to pathological processes.

  17. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2009-05-18

    May 18, 2009 ... Home; Journals; Journal of Biosciences; Volume 34; Issue 2. Clipboard: Snakes and ladders: the ups and downs of animal segmentation. Ramray Bhat Stuart A Newman. Volume 34 Issue 2 June 2009 pp 163-166. Fulltext. Click here to view fulltext PDF. Permanent link:

  18. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 5. Combinative effects of a bacterial type-III effector and a biocontrol bacterium on rice growth and disease resistance. Haiying Ren Ganyu Gu Juying Long Qian Yin Tingquan Wu Tao Song Shujian Zhang Zhiyi Chen Hansong Dong. Reviews Volume 31 Issue 5 ...

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 36; Issue 4. Eu-Detect: An algorithm for detecting eukaryotic sequences in metagenomic data sets. Monzoorul Haque Mohammed Sudha Chadaram Dinakar Dinakar Komanduri Tarini Shankar Ghosh Sharmila S Mande. Articles Volume 36 Issue 4 September 2011 pp 709- ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 28; Issue 4. Volume 28, Issue 4. June 2003, pages 359-528. pp 359-360. Clipboard: Severe acute respiratory syndrome (SARS): an old virus jumping into a new host or a new creation? M S Shaila · More Details Fulltext PDF. pp 361-362. Clipboard: Blueprint of a red mould: ...

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 26; Issue 2. The roots of ancient medicine: an historical outline. B V Subbarayappa. Perspectives Volume 26 Issue 2 June 2001 pp 135-143. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/026/02/0135-0143. Author Affiliations.

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 5. Cytomixis impairs meiosis and influences reproductive success in Chlorophytum comosum (Thunb) Jacq. – an additional strategy and possible implications. S K Lattoo S Khan S Bamotra A K Dhar. Reviews Volume 31 Issue 5 December 2006 pp 629-637 ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 42; Issue 1. Overexpression of hsa-miR-939 follows by NGFR down-regulation and apoptosis reduction. FAHIMEH HOSSEINI AGHDAEI BAHRAM M SOLTANI SADAT DOKANEHIIFARD SEYED JAVAD MOWLA MASOUD SOLEIMANI. Article Volume 42 Issue 1 March 2017 ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 31; Issue 1. Issue front cover thumbnail. Volume 31, Issue 1. March 2006, pages 1-176e. pp 1-2. Clipboard: Ancient Indian roots? Denise R Carvalho-Silva Tatiana Zerjal Chris Tyler-Smith · More Details Fulltext PDF. pp 3-4. Commentary: Magic with moulds: Meiotic and ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 29; Issue 1. What impact, if any, has feminism had on science? Evelyn Fox Keller. Perspectives Volume 29 Issue 1 March 2004 pp 7-13. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/029/01/0007-0013. Author Affiliations.

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Journals; Journal of Biosciences; Volume 35; Issue 1. Transgene transmission in South American catfish (Rhamdia quelen) larvae by sperm-mediated gene transfer. Tiago Collares Vinicius Farias Campos Fabiana Kömmling Seixas Paulo V Cavalcanti Odir A Dellagostin Heden Luiz M Moreira João Carlos Deschamps.

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2010-11-09

    Nov 9, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 4. What history tells us XXII. The French neo-Lamarckians. Michel Morange. Series Volume 35 Issue 4 December 2010 pp 515-517. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/035/04/0515-0517 ...

  8. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2006-05-06

    May 6, 2006 ... Home; Journals; Journal of Biosciences; Volume 31; Issue 2. Kenneth Raper, Elisha Mitchell and Dictyostelium. Eugene R Katz. Perspectives Volume 31 Issue 2 June 2006 pp 195-200. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/031/02/0195-0200 ...

  9. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2008-01-31

    Jan 31, 2008 ... Home; Journals; Journal of Biosciences; Volume 33; Issue 1. Biological time is fractal: Early events reverberate over a life time. David Lloyd. Perspectives Volume 33 Issue 1 March 2008 pp 9-19. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/jbsc/033/01/0009- ...

  10. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Anandasankar Ray1 2 Wynand Van Der Goes Van Naters2 3 John R Carlson2. Department of Entomology, University of California, Riverside, CA 92521, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA; School of Biosciences, Cardiff University, Cardiff, UK ...

  11. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2010-02-10

    Feb 10, 2010 ... Home; Journals; Journal of Biosciences; Volume 35; Issue 1. What history tells us XX. Felix Haurowitz (1896–1987) – A difficult journey in the political and scientific upheavals of the 20th century. Michel Morange. Series Volume 35 Issue 1 March 2010 pp 17-20 ...

  12. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2005-11-15

    Nov 15, 2005 ... Home; Journals; Journal of Biosciences; Volume 30; Issue 5. What history tells us III. André Lwoff: From protozoology to molecular definition of viruses. Michel Morange. Series Volume 30 Issue 5 December 2005 pp 591-594. Fulltext. Click here to view fulltext PDF. Permanent link:

  13. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2005-11-23

    Nov 23, 2005 ... Home; Journals; Journal of Biosciences; Volume 30; Issue 5. Commentary: Neuronal survival in epilepsy: to die or not to die? Subramaniam Ganesh Shweta Singh. Volume 30 Issue 5 December 2005 pp 561-566. Fulltext. Click here to view fulltext PDF. Permanent link:

  14. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 34; Issue 6 ... of R. solani (35 colony-forming units/g dry soil) was relatively high in the soil we studied, and ... School of Environment, Resources and Development, Asian Institute of Technology, ...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Journals; Journal of Biosciences; Volume 28; Issue 2. Integrative microbiology – the third Golden Age. Moselio Schaechter. Perspectives Volume 28 Issue 2 March 2003 pp 149-154 ...

  16. Prevalence and clinical significance of anti-C1q antibodies in ...

    African Journals Online (AJOL)

    Asmaa Hegazy

    2012-04-21

    Apr 21, 2012 ... sists of 20 patients with musculoskeletal manifestations, mainly arthritis ... C1q have been found in many different autoimmune diseases, ... improve our diagnostic potential, from these, anti-C1q anti- ... Subjects and methods.

  17. Youtube for millennial nursing students; using internet technology to support student engagement with bioscience.

    Science.gov (United States)

    Johnston, Amy Nb; Barton, Matthew J; Williams-Pritchard, Grant A; Todorovic, Michael

    2018-06-09

    Undergraduate nursing programs typically include students with limited 'on-campus' time who need learning resources that are flexible, technologically appropriate, remotely-accessible (mobile smart devices), and above all, engaging. This has presented academics with challenges surrounding institutional security firewalls, password-access requirements, intellectual property/ownership and staff/student privacy. To overcome these challenges a collection of evidence-based YouTube videos, posted on the Biological Sciences YouTube Channel, supported by the Biosciences in Nurse Education, and underpinned by Benner's pedagogical framework, were developed with the intention of moving students from novice to competent clinical bioscience users. The videos are highly successful; with over 310,000 views, 1.5 million minutes of viewing and more than 5000 subscribers since its inception (YouTube videos was enhanced by their familiarity with the presenter and the breadth of information available in small portions, creating a solid basis for the development of bioscience-competent nursing graduates. Moreover, these open source videos provide a free resource for continual revision and professional development informed by an international minimum bioscience standard for nurses post registration. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

  18. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2009-01-30

    Current research projects have focused Environmental Biosciences Program (EBP) talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene, low-dose ionizing radiation (gamma and neutron) and alpha radiation from plutonium. Trichloroethylene research has been conducted as a joint collaborative effort with the University of Georgia. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the United States Department of Energy (DOE). Laboratory work has been completed on several trichloroethylene risk assessment projects, and these projects have been brought to a close. Plans for restructuring the performance schedule of the remaining trichloroethylene projects have been submitted to the department. A comprehensive manuscript on the scientific basis of trichloroethylene risk assessment is in preparation. Work on the low-dose radiation risk assessment projects is also progressing at a slowed rate as a result of funding uncertainties. It has been necessary to restructure the proponency and performance schedule of these projects, with the project on Low-Dose Radiation: Epidemiology Risk Models transferred to DOE Office of Science proponency under a separate funding instrument. Research on this project will continue under the provisions of the DOE Office of Science funding instrument, with progress reported in accordance with the requirements of that funding instrument. Progress on that project will no longer be reported in quarterly reports for DE-FC09-02CH11109. Following a meeting at the Savannah River Site on May 8, 2008, a plan was submitted for development of an epidemiological cohort study and prospective medical surveillance system for the assessment of disease rates among workers at the Savannah River

  19. Object-oriented programming for the biosciences.

    Science.gov (United States)

    Wiechert, W; Joksch, B; Wittig, R; Hartbrich, A; Höner, T; Möllney, M

    1995-10-01

    The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.

  20. Nitrogen-15 reference book: medicine and biosciences

    International Nuclear Information System (INIS)

    Faust, H.

    1983-04-01

    A comprehensive bibliography on the application of the stable nitrogen isotope 15 N in medicine, animal nutrition and physiology, biosciences, and related disciplines is presented. The literature pertaining to this paper covers the period from 1977 to 1981. The references are completed by an index of all authors and a subject index with special emphasis to the used organisms, labelled compounds, and tracer techniques, respectively. (author)

  1. Case report: Severe hemolytic disease of the fetus and newborn due to anti-C+G.

    Science.gov (United States)

    Jernman, Riina; Stefanovic, Vedran; Korhonen, Anu; Haimila, Katri; Sareneva, Inna; Sulin, Kati; Kuosmanen, Malla; Sainio, Susanna

    2015-01-01

    Anti-G is commonly present with anti-D and/or anti-C and can confuse serological investigations. in general, anti-G is not considered a likely cause of severe hemolytic disease of the fetus and newborn (HDFN), but it is important to differentiate it from anti-D in women who should be administered anti-D immunoglobulin prophylaxis. We report one woman with three pregnancies severely affected by anti-C+G requiring intrauterine treatment and a review of the literature. In our case, the identification of the correct antibody was delayed because the differentiation of anti-C+G and anti-D+C was not considered important during pregnancy since the father was D-. In addition, anti-C+G and anti-G titer levels were not found to be reliable as is generally considered in Rh immunization. Severe HDFN occurred at a maternal anti-C+G antibody titer of S and anti-G titer of 1 in comparison with the critical titer level of 16 or more in our laboratory. close collaboration between the immunohematology laboratory and the obstetric unit is essential. In previously affected families, early assessment for fetal anemia is required even when titers are low.

  2. Developing Research Capabilities in Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Donald D.

    2008-01-01

    Scientists founded the Life Sciences Research Foundation (LSRF) in 1983 as a non-profit pass through foundation that awards post doctoral fellowships in all areas of the life sciences. LSRF scientists review hundreds of applications each year from PhDs seeking support. For example this year, our 26th, we received 800 applications and our peer review committee will choose about 50 finalists who are eligible for these awards. We have no endowment so we solicit sponsors each year. The fellowships are sponsored by research oriented companies, foundations, philanthropists, the Howard Hughes Medical Institute, and other organizations who believe in the value of awarding fellowships to the best and the brightest young scientists. Our web site has a complete listing of all details about LSRF (http://www.lsrf.org/). In the late 1980s the Division of Bioscience in the Office of Basic Energy Science, a granting agency of the Department of Energy, joined this partnership. Bioscience's mandate was to support non-medical microbiology and plant sciences. LSRF received a series of 5 year grants from DOE to award fellowships to our top applicants in these fields of research. We began to support DOE-Energy Bioscience post doctoral fellows in 1989. From 1989 through 2004 when DOE funding ended our partnership awarded 41 DOE-Energy Bioscience Fellows of the Life Sciences Research Foundation. Each of these was a three year fellowship. DOE-Energy Biosciences was well matched with LSRF. Our extensive peer review screened applicants in all areas of the life sciences. Most LSRF sponsors are interested in supporting fellows who work on diseases. At the time that we began our partnership with DOE we had no sponsors willing to support plant biology and non medical microbiology. For 15 years DOE played a major role in the training of the very best young scientists in these important fields of research simply through its support of LSRF post doctoral fellows. Young scientists interested in

  3. Anti-C1q autoantibodies in patients with neuromyelitis optica spectrum disorders.

    Science.gov (United States)

    Yoshikura, Nobuaki; Kimura, Akio; Hayashi, Yuichi; Inuzuka, Takashi

    2017-09-15

    We examined anti-complement C1q (C1q) autoantibody levels in serum and cerebrospinal fluid (CSF) samples of patients with neuromyelitis optica spectrum disorders (NMOSD). We analyzed the correlations between anti-C1q autoantibody levels and the clinical and other CSF characteristics of NMOSD. Serum and CSF anti-C1q autoantibody levels increased during the acute phase of NMOSD, reverting to the same levels as controls during remission. CSF anti-C1q autoantibody levels during the acute phase correlated with several markers reflecting disease severity, Expanded Disability Status Scale worsening, spinal cord lesion length in cases with myelitis, CSF protein and interleukin-6 levels, and CSF/serum albumin ratios. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Anti-c-MET Nanobody - a new potential drug in multiple myeloma treatment.

    Science.gov (United States)

    Slørdahl, Tobias Schmidt; Denayer, Tinneke; Moen, Siv Helen; Standal, Therese; Børset, Magne; Ververken, Cedric; Rø, Torstein Baade

    2013-11-01

    c-MET is the tyrosine kinase receptor of the hepatocyte growth factor (HGF). HGF-c-MET signaling is involved in many human malignancies, including multiple myeloma (MM). Recently, multiple agents have been developed directed to interfere at different levels in HGF-c-MET signaling pathway. Nanobodies are therapeutic proteins based on the smallest functional fragments of heavy-chain-only antibodies. In this study, we wanted to determine the anticancer effect of a novel anti-c-MET Nanobody in MM. We examined the effects of an anti-c-MET Nanobody on thymidine incorporation, migration, adhesion of MM cells, and osteoblastogenesis in vitro. Furthermore, we investigated the effects of the Nanobody on HGF-dependent c-MET signaling by Western blotting. We show that the anti-c-MET Nanobody effectively inhibited thymidine incorporation of ANBL-6 MM cells via inhibition of an HGF autocrine growth loop and thymidine incorporation in INA-6 MM cells induced by exogenous HGF. HGF-induced migration and adhesion of INA-6 were completely and specifically blocked by the Nanobody. Furthermore, the Nanobody abolished the inhibiting effect of HGF on bone morphogenetic protein-2-induced alkaline phosphatase activity and the mineralization of human mesenchymal stem cells. Finally, we show that the Nanobody reduced phosphorylation of tyrosine residues in c-MET, MAPK, and Akt. We also compared the Nanobody with anti-c-MET monoclonal antibodies and revealed the similar or better effect. The anti-c-MET Nanobody inhibited MM cell migration, thymidine incorporation, and adhesion, and blocked the HGF-mediated inhibition of osteoblastogenesis. The anti-c-MET Nanobody might represent a novel therapeutic agent in the treatment of MM and other cancers driven by HGF-c-MET signaling. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Hemolytic Disease of the Newborn Due to Anti-c Isoimmunization: A Case Report.

    Science.gov (United States)

    Sheeladevi, C S; Suchitha, S; Manjunath, G V; Murthy, Srinivas

    2013-09-01

    The Rhesus (Rh) blood group is one of the most complex blood groups known in humans. It has remained of primary importance in obstetrics, being the main cause of hemolytic disease of the newborn (HDN). Anti-D causes the most severe form of HDN. Other Rh allo antibodies that are capable of causing severe HDN include anti-c, which clinically is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of an Rh positive mother.

  6. Multimedia Interactive eBooks in Laboratory Bioscience Education

    Science.gov (United States)

    Morris, Neil P.; Lambe, James

    2017-01-01

    Bioscience students in the UK higher education system are making increasing use of technology to support their learning within taught classes and during private study. This experimental study was designed to assess the role for multimedia interactive eBooks in bioscience laboratory classes, delivered using a blended learning approach. Thirty-nine…

  7. [Role of anti c-mpl antibody in systemic lupus erythematosus with thrombocytopenia].

    Science.gov (United States)

    Yang, Tuo; Huang, Ci Bo; Lai, Bei; Zhao, Li Ke; Chen, Ying Juan; Zhao, Yue Tao; Zhang, Chun Mei; Zeng, Xiao Feng

    2012-04-18

    To determine whether anti-thrompoietin receptor (TPO-R, c-mpl) antibody contributes to thrombocytopenia in systemic lupus erytematosus (SLE) and explore the pathogenic role of this antibody. Sera from 24 SLE patients with thrombocytopenia, 27 SLE patients having normal platelet counts with a history of thrombocytopenia, 18 SLE patients with neither thrombocytopenia nor post thrombocytopenia and 18 healthy controls were collected. Anti c-mpl antibodies were detected by an indirected ELISA assay. The serum TPO levels were measured by an ELISA assay. Clinical findings, autoantibody profiles, and SLEDAI were evaluated. Serum anti c-mpl antibodies were detected in 18.8% of the SLE patientis. The frequency of this antibody in SLE with thrombocytopenia, SLE with a history of thrombocytopenia and SLE without thrombocytopenia were of no difference (P=0.600). In the patients with anti c-mpl antibodies, their platelet counts were decreased(P=0.025) and serum TPO levels elevated(P=0.038) than those in the patients without, while there were no differences between the two groups in C3, C4, ESR, CRP level, the frequency of ANA, dsDNA, ANCA and SLEDAI. Anti c-mpl antibody contributes to SLE-associated thrombocytopenia by functionally blocking an interaction between thrombopoietin and c-mpl, which might inhibit TPO-dependent megakaryocyte proliferation and differentiation.

  8. Introducing bioinformatics, the biosciences' genomic revolution

    CERN Document Server

    Zanella, Paolo

    1999-01-01

    The general audience for these lectures is mainly physicists, computer scientists, engineers or the general public wanting to know more about what’s going on in the biosciences. What’s bioinformatics and why is all this fuss being made about it ? What’s this revolution triggered by the human genome project ? Are there any results yet ? What are the problems ? What new avenues of research have been opened up ? What about the technology ? These new developments will be compared with what happened at CERN earlier in its evolution, and it is hoped that the similiraties and contrasts will stimulate new curiosity and provoke new thoughts.

  9. Heavy quark symmetry and weak decays of the b-baryons in pentaquarks with a c anti c component

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Ahmed [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ahmed, Ishtiaq; Rehman, Abdur [Quaid-i-Azam Univ., Islamabad (Pakistan). National Centre for Physics; Aslam, M. Jamil [Quaid-i-Azam Univ., Islamabad (Pakistan). Physics Dept.

    2016-06-15

    The discovery of the baryonic states P{sup +}{sub c}(4380) and P{sup +}{sub c}(4450) by the LHCb collaboration in the process pp→b anti b→Λ{sup 0}{sub b}X, followed by the decay Λ{sup 0}{sub b}→J/ψpK{sup -} has evoked a lot of theoretical interest. These states have the minimal quark content c anti cuud, as suggested by their discovery mode J/ψ p, and the preferred J{sup P} assignments are (5)/(2){sup +} for the P{sup +}{sub c}(4450) and (3)/(2){sup -} for the P{sup +}{sub c}(4380). In the compact pentaquark hypothesis, in which they are interpreted as hidden charm diquark-diquark-antiquark baryons, the assigned spin and angular momentum quantum numbers are P{sup +}{sub c}(4380)={ anti c[cu]_s_=_1[ud]_s_=_1; L_P=0, J"P=(3)/(2)"-} and P{sup +}{sub c}(4450)={ anti c[cu]_s_=_1[ud]_s_=_0; L_P=1, J"P=(5)/(2)"+}. The subscripts denote the spin of the diquarks and L{sub P}=0,1 are the orbital angular momentum quantum numbers of the pentaquarks. We point out that heavy quark limit, the spin of the light diquark in heavy baryons becomes a good quantum number, which has consequences for the decay Λ{sup 0}{sub b}→J/ψpK{sup -}. With the quantum numbers assigned above for the two pentaquarks, this would allow only the higher mass pentaquark state P{sup +}{sub c}(4450) having [ud]{sub s=0} to be produced in Λ{sup 0}{sub b} decays, whereas the lower mass state P{sup +}{sub c}(4380) having [ud]{sub s=1} is disfavored, requiring a different interpretation. Pentaquark spectrum is rich enough to accommodate a J{sup P}=(3)/(2){sup -} state, which has the correct light diquark spin { anti c[cu]_s_=_1[ud]_s_=_0; L_P=0, J"P=(3)/(2)"-} to be produced in Λ{sup 0}{sub b} decays. Assuming that the mass difference between the charmed pentaquarks which differ in the orbital angular momentum L by one unit is similar to the corresponding mass difference in the charmed baryons, m[Λ{sup +}{sub c}(2625); J{sup P}=(3)/(2){sup -}]-m[Λ{sup +}{sub c}(2286); J{sup P}=(1)/(2){sup +}]

  10. The (Mathematical) Modeling Process in Biosciences.

    Science.gov (United States)

    Torres, Nestor V; Santos, Guido

    2015-01-01

    In this communication, we introduce a general framework and discussion on the role of models and the modeling process in the field of biosciences. The objective is to sum up the common procedures during the formalization and analysis of a biological problem from the perspective of Systems Biology, which approaches the study of biological systems as a whole. We begin by presenting the definitions of (biological) system and model. Particular attention is given to the meaning of mathematical model within the context of biology. Then, we present the process of modeling and analysis of biological systems. Three stages are described in detail: conceptualization of the biological system into a model, mathematical formalization of the previous conceptual model and optimization and system management derived from the analysis of the mathematical model. All along this work the main features and shortcomings of the process are analyzed and a set of rules that could help in the task of modeling any biological system are presented. Special regard is given to the formative requirements and the interdisciplinary nature of this approach. We conclude with some general considerations on the challenges that modeling is posing to current biology.

  11. Conference scene: Select Biosciences Epigenetics Europe 2010.

    Science.gov (United States)

    Razvi, Enal S

    2011-02-01

    The field of epigenetics is now on a geometric rise, driven in a large part by the realization that modifiers of chromatin are key regulators of biological processes in vivo. The three major classes of epigenetic effectors are DNA methylation, histone post-translational modifications (such as acetylation, methylation or phosphorylation) and small noncoding RNAs (most notably microRNAs). In this article, I report from Select Biosciences Epigenetics Europe 2010 industry conference held on 14-15 September 2010 at The Burlington Hotel, Dublin, Ireland. This industry conference was extremely well attended with a global pool of delegates representing the academic research community, biotechnology companies and pharmaceutical companies, as well as the technology/tool developers. This conference represented the current state of the epigenetics community with cancer/oncology as a key driver. In fact, it has been estimated that approximately 45% of epigenetic researchers today identify cancer/oncology as their main area of focus vis-à-vis their epigenetic research efforts.

  12. Environmental Biosciences Quarterly Report, September - December, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  13. Environmental Biosciences Program Report for Year Three

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  14. Environmental Biosciences Program Report for Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-10-15

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  15. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  16. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.d.

    2003-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  17. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  18. Second Quarter Report Environmental Biosciences Program

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2002-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  19. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  20. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  1. What is it really? Anti-G or Anti-D plus Anti-C: Clinical Significance in Antenatal Mothers.

    Science.gov (United States)

    Das, Soumya; Shastry, Shamee; Murugesan, M; B, Poornima Baliga; Shastry, Shamee

    2017-06-01

    G antigen of Rh blood group system is present either along with D and/or C positive red cells. Hence, [serologically anti-G presents with the similar picture as that of multiple antibodies (anti-D + anti-C). Differentiating them is important as anti-D + anti-C causes severe hemolytic disease of the fetus and newborn than anti-G. In pregnancies with anti-G alone, alloimmunization due to D antigen could be prevented by prophylactic administration of RhIg. Differentiating between anti-D + C from anti-G in alloimmunized pregnant mothers becomes essential. Sera from antenatal mothers, whose antibody identification by 11-cell panel gave a pattern for anti-D and anti-C were selected. Extended phenotyping for Rh system was performed for these antenatal cases. Differential adsorption and elution testing using R 2 R 2 cells initially and r'r cells subsequently were performed to distinguish anit-G from anti-D + anti-C. Antibody titers of these antibodies were determined and their clinical outcome in the newborn was followed. A pattern suggestive of anti D and anti C on antibody identification were observed in six antenatal cases. On further workup 50 % of them confirmed to have anti G. Antibody titers of anti-G and anti-C were lower than that of Anti-D. All newborns were sensitized in vivo and the antibody specificity in them were confirmed with elution studies. The mothers who had only anti-G were subsequently administered with an appropriate dose of RhIg.Differential adsorption and elution studies help in identifying anti-G and distinguishing it from anti-D plus anti-C, thus helping in better patient management.

  2. Environmental Biosciences Program Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  3. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation s need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyles (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  4. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  5. Environmental Biosciences Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk based decision-making. Questions, comments or requests for further information concerning the activities under this

  6. Erratum Journal of Biosciences Volume 34, Number 2, November ...

    Indian Academy of Sciences (India)

    Prakash

    (1) Page 709, Introduction, 4th line from top: 3500 m to be read as 500 m. (2) Page 710, Figure 2 caption, line 1: 3500 m to be read as 500 m. The above corrections require to be made in the printed version of the article. The article that appear on the Journal of. Biosciences Web site will contain these corrections.

  7. Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class

    Science.gov (United States)

    Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija

    2015-01-01

    University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…

  8. Integrating anticipated nutrigenomics bioscience applications with ethical aspects

    NARCIS (Netherlands)

    Levesque, L.; Ozdemir, V.; Gremmen, B.; Godard, B.

    2008-01-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues

  9. Measurements of the Z partial decay width into c anti c and multiplicity of charm quarks per b decay

    International Nuclear Information System (INIS)

    Abreu, P.; Adam, W.; Adye, T.

    2000-01-01

    The partial decay width R c of the Z into c anti c quark pair and the number of charm quarks n c per b decay are measured with the DELPHI detector at LEP 1. Particle identification provides clear D 0 , D + , D s + and Λ c + signatures. The charm hadron production rate is measured in each channel by a fit to the scaled energy, impact parameter information and the invariant mass spectrum. Two measurements of R c are presented, from the D *+ production rate and from the overall charm counting, including strange charm baryon production, in c anti c events. The multiplicity n c , which includes hidden c anti c and strange charm baryon production, is inferred from the charm counting in b anti b events. The final results are R c =0.1665±0.0095 and n c =1.166±0.086. (orig.)

  10. Association of anti C1q and ds-DNA levels with the pathogenesis of Lupus Nephritis among SLE patients

    Directory of Open Access Journals (Sweden)

    Zara Sohail

    2018-02-01

    Full Text Available Background: Lupus nephritis (LN is the most common and serious complication associated with SLE and it results in significant morbidity and mortality. It is known by several studies that patients of LN have higher levels of anti-dsDNA and anti-C1q compared with SLE patients without renal involvement. The current study was designed to determine and compare the level of anti-dsDNA and anti-C1q in patients of SLE with and without lupus nephritis in the Pakistani population. This current study was also aimed at providing proof that anti-C1q levels are more prominent in LN/non-LN SLE as compared to anti-dsDNA. This project may help in the determination of results in Pakistan and contribute to the further confirmation of the sensitivity of anti-C1q. Method: The patient samples were collected from Sheikh Zayed hospital, Lahore. These patients were clinically diagnosed by the Rheumatologists as SLE and LN positive on the basis of ACR and SLEDAI scoring criteria. This study was performed and samples were analyzed in the Department of Medical and Laboratory Sciences, Imperial College of Business Study, Lahore on the patient’s serum by ELISA technique. Result: About 38% (12 patients with LN were positive for anti-dsDNA and 31% (9 SLE patients without LN were positive whereas about 38.7% (12 were anti-dsDNA negative in LN cases and 58.6% (17 in SLE without LN. In case of anti-C1q 100% (31 of these LN patients were positive and 93.1% (27 patients SLE without LN showed positive anti C1q results. Only 6.9% (2 patients showed negative results for anti-C1q in LN negative patients Conclusion: The higher levels of anti-C1q suggest that it may be a better diagnostic marker for LN than that of anti-dsDNA and that it can be helpful in the prognosis of SLE patients.

  11. Bioscience methodologies in physical chemistry an engineering and molecular approach

    CERN Document Server

    D'Amore, Alberto

    2013-01-01

    The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

  12. Anti-G with concomitant anti-C and anti-D: A case report in a pregnant woman

    Directory of Open Access Journals (Sweden)

    Rabeya Yousuf

    2017-01-01

    Full Text Available The G antigen of Rh blood group system is present in almost all D-positive or C-positive red cells but absent from red cells lacking D and C antigens. The differentiation of anti-D and anti-C from anti-G is not necessary for routine transfusion; however, during pregnancy, it is important because anti-G can masquerade as anti-D and anti-C with initial antibody testing. The false presence of anti-D will exclude the patient from receiving anti-D immunoglobulin (RhIG when the patient actually is a candidate for RhIG prophylaxis. Moreover, patients with positive anti-D or anti-G are at risk of developing hemolytic disease of the fetus and newborn and need close monitoring. Thus, proper identification allows the clinicians to manage patients properly. This case report highlights a rare case of anti-G together with anti-D and anti-C in a pregnant woman. This report disseminates knowledge on identification of anti-G and its importance in pregnant women.

  13. Anti-G with concomitant anti-C and anti-D: A case report in a pregnant woman.

    Science.gov (United States)

    Yousuf, Rabeya; Mustafa, Ahmad Nasirudin; Ho, Siew-Ling; Tang, Yee-Loong; Leong, Chooi-Fun

    2017-01-01

    The G antigen of Rh blood group system is present in almost all D-positive or C-positive red cells but absent from red cells lacking D and C antigens. The differentiation of anti-D and anti-C from anti-G is not necessary for routine transfusion; however, during pregnancy, it is important because anti-G can masquerade as anti-D and anti-C with initial antibody testing. The false presence of anti-D will exclude the patient from receiving anti-D immunoglobulin (RhIG) when the patient actually is a candidate for RhIG prophylaxis. Moreover, patients with positive anti-D or anti-G are at risk of developing hemolytic disease of the fetus and newborn and need close monitoring. Thus, proper identification allows the clinicians to manage patients properly. This case report highlights a rare case of anti-G together with anti-D and anti-C in a pregnant woman. This report disseminates knowledge on identification of anti-G and its importance in pregnant women.

  14. 75 FR 64733 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal

    Science.gov (United States)

    2010-10-20

    ...] Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal AGENCY: Food... announcing that Arcadia Biosciences, Inc., has filed a petition proposing that the food additive regulations..., Davis, CA 95618. The petition proposes to amend the food additive regulations in part 573 Food Additives...

  15. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    CSCs) has been confirmed by a number of studies on experimental animal models. Nevertheless, it was shown that CSC hypotheses have several limitations and inconsistencies regarding the explanation of CSC origin, CSC identification and ...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Antioxidant enzymes; diabetes; glucose metabolism; lens; polyol pathway; Trigonella foenum graecum; vanadate ... However the toxicity associated with vanadium limits its role as therapeutic agent for diabetic treatment. ... Volume 43 | Issue 1

  17. Full text and figure display improves bioscience literature search.

    Science.gov (United States)

    Divoli, Anna; Wooldridge, Michael A; Hearst, Marti A

    2010-04-14

    When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  18. Full text and figure display improves bioscience literature search.

    Directory of Open Access Journals (Sweden)

    Anna Divoli

    Full Text Available When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  19. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    As far as species abundance largely determines the rate of generation of intraspecific endogenous genetic variation, the result obtained suggests that the latter rate is not a limiting factor for speciation. Furthermore, the observed approximate constancy of speciation rates in different taxa cannot be accounted for by assuming ...

  20. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... oxyradicals invoked higher activity of antioxidant enzymes like superoxide dismutase and peroxidase under ambient UV, they also imposed limitation on the photosynthetic efficiency of PSII. Exclusion of UV components (UV-B 280–315 nm; UV-A 315–400 nm) translated to enhanced photosynthesis, growth and biomass.

  1. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    EDS1 interacts with its positive co-regulator phytoalexin deficient 4 (PAD4), resulting in mobilization of the salicylic acid defence pathway. Limited information regarding this interaction in rice is available. To study this interaction, a model of EDS1 and PAD4 proteins from rice was generated and validated with Accelrys DS ...

  2. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Cyclic adenosine 5′-phosphate (cAMP) is a global regulator of gene expression in Escherichia coli. Despite decades of intensive study, the quantitative effect and regulatory function of cAMP remain the subjects of considerable debate. Here, we analyse the data in the literature to show that: In carbon-limited cultures ...

  3. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    2007-03-22

    Mar 22, 2007 ... Keywords. Caspases; Hsp90; Hsp70; Hsp60; Hsp27; hsr-omega. Abstract. Heat shock induced gene expression and other cellular responses help limit the damage caused by stress and thus facilitate cellular recovery. Cellular damage also triggers apoptotic cell death through several pathways. This paper ...

  4. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... were created to analyse pathological changes in tissues. The limited data available showed that normal gastric tissue had stronger absorption than cancerous tissue over a wide region in the four patients. There was a significant decrease in total biomolecular components for cancerous tissue compared with normal tissue ...

  5. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Association of genetic polymorphism in GH gene with milk production traits in .... Transgenic tobacco plants expressing BoRS1 gene from Brassica oleracea var. ... Water stress is by far the leading environmental stress limiting crop yields worldwide. .... in the brown algal order Ectocarpales: The ``codon impact parameter".

  6. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    The size was also confirmed by linearizing the circle with BsaHI, and by limited DNAseI digestion. The restriction map of the E. dispar rDNA circle showed close similarity to EhR1, the rDNA circle of E. histolytica strain HM-1:IMSS which has two rDNA units per circle. The various families of short tandem repeats found in the ...

  7. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends

    International Nuclear Information System (INIS)

    2010-01-01

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  8. Fc RIIA Genotypes and Its Association with Anti-C1q Autoantibodies in Lupus Nephritis (LN Patients from Western India

    Directory of Open Access Journals (Sweden)

    Vandana Pradhan

    2010-01-01

    Full Text Available To identify Fc RIIA genotypes in Systemic Lupus Erythematosus (SLE patients and their association with anti-C1q antibodies. Methods. Fc RIIA genotyping was done in eighty Indian SLE patients and eighty healthy controls using allele-specific PCR. Anti-C1q antibodies were measured by ELISA. Results. LN patients showed higher SLEDAI (6–32 as compared to SLE patients without renal manifestations and had SLEDAI between 6–23. Fc RIIA polymorphic frequency in SLE patients was R131/H131 (67.5%, R131/R131 (20% and H131/ H131 (12.5% as against that of normal population (62.5%, 10%, and 27.5%, respectively. Sixty two patients (77.5% showed positivity for anti-C1q antibodies. LN patients showed elevated levels of anti-C1q antibodies (258.2u/ml±38.5U/mL as compared to SLE patients without nephritis (134.6±24.6 U/mL. Among anti-C1q positive patients, 71% had R131/H131 genotype, 22.6% had R131/R131 and remaining 6.4%, patients had H131/H131 genotype. All anti-C1q positive patients with R131/R131 genotype had elevated levels of anti-C1q antibodies (>100 U/ml, whereas among anti-C1q negative patients, none had R131/R131 genotype. Conclusion. This first report on Indian SLE patients supports the hypothesis that Fc RIIA R131 variant over expression may constitute a susceptibility factor for development of severe SLE manifestations in LN patients.

  9. Applications of computational tools in biosciences and medical engineering

    CERN Document Server

    Altenbach, Holm

    2015-01-01

     This book presents the latest developments and applications of computational tools related to the biosciences and medical engineering. It also reports the findings of different multi-disciplinary research projects, for example, from the areas of scaffolds and synthetic bones, implants and medical devices, and medical materials. It is also shown that the application of computational tools often requires mathematical and experimental methods. Computational tools such as the finite element methods, computer-aided design and optimization as well as visualization techniques such as computed axial tomography open up completely new research fields that combine the fields of engineering and bio/medical. Nevertheless, there are still hurdles since both directions are based on quite different ways of education. Often even the “language” can vary from discipline to discipline.

  10. Division of Agro technology and Biosciences: Past, Present and Future

    International Nuclear Information System (INIS)

    Khairuddin Abdul Rahim

    2012-01-01

    In presenter speech, he outlined several topics regarding development of Agro technology and Biosciences Division from 31 years ago. This division started with Unit Sains Hidupan Liar under PUSPATI in 1981 and change their names to Program Isotop dan Sinaran dalam Biologi dan Pertanian under Nuclear Technology Unit (UTN) (1983). In 1990 their premise change to MINT-Tech Park. This program responsible for conducting research in agro technology using nuclear technology. Several achievements achieved by this division since established. They also succeed in mutating banana namely Novaria banana (1994), Tongkat Ali rice (1990), ground nut (2003), orchids, organic fertilizer and foliage in 2000. The vision of this division are to promote and enhance innovation and applications in nuclear technology to achieve security in food productivity, safety and quality and ecological awareness for economics competitiveness and vibrancy in agrobioindustry and community development. (author)

  11. Targeted Delivery of Neutralizing Anti-C5 Antibody to Renal Endothelium Prevents Complement-Dependent Tissue Damage

    Directory of Open Access Journals (Sweden)

    Paolo Durigutto

    2017-09-01

    Full Text Available Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process. To this end, we generated Ergidina, a neutralizing recombinant anti-C5 human antibody coupled with a cyclic-RGD peptide, with a distinctive homing property for ischemic endothelial cells and effective in controlling tissue damage in a rat model of renal ischemia/reperfusion injury (IRI. As a result of its preferential localization on renal endothelium, the molecule induced complete inhibition of complement activation at tissue level, and local protection from complement-mediated tissue damage without affecting circulating C5. The ex vivo binding of Ergidina to surgically removed kidney exposed to cold ischemia supports its therapeutic use to prevent posttransplant IRI leading to delay of graft function. Moreover, the finding that the ex vivo binding of Ergidina was not restricted to the kidney, but was also seen on ischemic heart, suggests that this RGD-targeted anti-C5 antibody may represent a useful tool to treat organs prior to transplantation. Based on this evidence, we propose preliminary data showing that Ergidina is a novel targeted drug to prevent complement activation on the endothelium of ischemic kidney.

  12. Is LabTutor a helpful component of the blended learning approach to biosciences?

    Science.gov (United States)

    Swift, Amelia; Efstathiou, Nikolaos; Lameu, Paula

    2016-09-01

    To evaluate the use of LabTutor (a physiological data capture and e-learning package) in bioscience education for student nurses. Knowledge of biosciences is important for nurses the world over, who have to monitor and assess their patient's clinical condition, and interpret that information to determine the most appropriate course of action. Nursing students have long been known to find acquiring useable bioscience knowledge challenging. Blended learning strategies are common in bioscience teaching to address the difficulties students have. Student nurses have a preference for hands-on learning, small group sessions and are helped by close juxtaposition of theory and practice. An evaluation of a new teaching method using in-classroom voluntary questionnaire. A structured survey instrument including statements and visual analogue response format and open questions was given to students who participated in Labtutor sessions. The students provided feedback in about the equipment, the learning and the session itself. First year (n = 93) and third year (n = 36) students completed the evaluation forms. The majority of students were confident about the equipment and using it to learn although a few felt anxious about computer-based learning. They all found the equipment helpful as part of their bioscience education and they all enjoyed the sessions. This equipment provides a helpful way to encourage guided independent learning through practice and discovery and because each session is case study based and the relationship of the data to the patient is made clear. Our students helped to evaluate our initial use of LabTutor and found the sessions enjoyable and helpful. LabTutor provides an effective learning tool as part of a blended learning strategy for biosciences teaching. Improving bioscience knowledge will lead to a greater understanding of pathophysiology, treatments and interventions and monitoring. © 2016 John Wiley & Sons Ltd.

  13. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

    Directory of Open Access Journals (Sweden)

    Carol Kilkenny

    2014-02-01

    Full Text Available In the last decade the number of bioscience journals has increased enormously, with many filling specialised niches reflecting new disciplines and technologies. The emergence of open-access journals has revolutionised the publication process, maximising the availability of research data. Nevertheless, a wealth of evidence shows that across many areas, the reporting of biomedical research is often inadequate, leading to the view that even if the science is sound, in many cases the publications themselves are not “fit for purpose”, meaning that incomplete reporting of relevant information effectively renders many publications of limited value as instruments to inform policy or clinical and scientific practice [1–21]. A recent review of clinical research showed that there is considerable cumulative waste of financial resources at all stages of the research process, including as a result of publications that are unusable due to poor reporting [22]. It is unlikely that this issue is confined to clinical research [2–14,16–20].

  14. Course-based undergraduate research experiences in molecular biosciences-patterns, trends, and faculty support.

    Science.gov (United States)

    Wang, Jack T H

    2017-08-15

    Inquiry-driven learning, research internships and course-based undergraduate research experiences all represent mechanisms through which educators can engage undergraduate students in scientific research. In life sciences education, the benefits of undergraduate research have been thoroughly evaluated, but limitations in infrastructure and training can prevent widespread uptake of these practices. It is not clear how faculty members can integrate complex laboratory techniques and equipment into their unique context, while finding the time and resources to implement undergraduate research according to best practice guidelines. This review will go through the trends and patterns in inquiry-based undergraduate life science projects with particular emphasis on molecular biosciences-the research-aligned disciplines of biochemistry, molecular cell biology, microbiology, and genomics and bioinformatics. This will provide instructors with an overview of the model organisms, laboratory techniques and research questions that are adaptable for semester-long projects, and serve as starting guidelines for course-based undergraduate research. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  15. Annual report and summaries of FY 1993 activities: Division of Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The mission of the Energy Biosciences program is to generate fundamental information about plants and non-health related microorganisms that will constitute the base for new biotechnologies as well as supply information to improve usages of such organisms in their current form. The collective aims are totally consistent with the Department of Energy`s objectives of developing alternate energy sources, replacements for otherwise fossil energy derived products and providing critical fundamental information for the preservation and restoration of environmental conditions affected by energy related activities. The EB program takes full advantage of its organizational locale in the Office of Basic Energy Sciences to directly interact with such disciplines as Materials Sciences, Chemistry, Engineering and Geosciences to promote cross-disciplinary research and planning activities. One of the major specific objectives of the EB program is to probe the enormous capabilities of the specified organisms to carry out biochemical conversions. The limitation to realization of entirely new products and processes via biotechnology is the lack of basic understanding of natural processes. Such knowledge will then afford the advantage of developing procedures to the benefit of people and their society in providing new products along with providing new employment possibilities. This document consists of abstracts of projects supported in FY 1993.

  16. Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

    Science.gov (United States)

    Mayne, Lynne

    2012-01-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

  17. Foods: Where Innovation, Agriculture, Molecular Biosciences and Human Nutrition Meet

    Directory of Open Access Journals (Sweden)

    Charles Brennan

    2012-11-01

    Full Text Available There is one commodity the world over that unites mankind—food. In 2011 the United Nations claimed that the world’s population had reached the seven billion mark, a number which is set to increase dramatically in the decades to come. Food security, supply and sustainability are of paramount concern to the future economic and social progress of humanity. It is the responsibility of the food industry, together with food scientists and technologists, to shoulder the burden of ensuring an adequate supply of nutritious, safe and sensorially acceptable foods for a range of demanding consumers. In responding to this challenge, we need to understand the link between agriculture, engineering, food processing, molecular biosciences, human nutrition, commercialisation and innovation. Access to information concerning the composition and quality of foods has never been so easy for consumers and technologists alike. A plethora of research publications are made available each month to scientists and associated interested parties. The outcomes of these research manuscripts are often distilled and disseminated into messages available to everyone through bulletin boards, forums and the popular press. Newspapers and new agencies constantly report on the latest pharma-medical finding, or news regarding food safety and security concerns. We live in an age where information is so readily available to everyone that the task of finding credible and reputable data can be difficult at times. Providing sound evidenced based research is where a peer-reviewed journal can provide clarity. [...

  18. Foods: Where Innovation, Agriculture, Molecular Biosciences and Human Nutrition Meet.

    Science.gov (United States)

    Brennan, Charles

    2012-11-21

    There is one commodity the world over that unites mankind-food. In 2011 the United Nations claimed that the world's population had reached the seven billion mark, a number which is set to increase dramatically in the decades to come. Food security, supply and sustainability are of paramount concern to the future economic and social progress of humanity. It is the responsibility of the food industry, together with food scientists and technologists, to shoulder the burden of ensuring an adequate supply of nutritious, safe and sensorially acceptable foods for a range of demanding consumers. In responding to this challenge, we need to understand the link between agriculture, engineering, food processing, molecular biosciences, human nutrition, commercialisation and innovation. Access to information concerning the composition and quality of foods has never been so easy for consumers and technologists alike. A plethora of research publications are made available each month to scientists and associated interested parties. The outcomes of these research manuscripts are often distilled and disseminated into messages available to everyone through bulletin boards, forums and the popular press. Newspapers and new agencies constantly report on the latest pharma-medical finding, or news regarding food safety and security concerns. We live in an age where information is so readily available to everyone that the task of finding credible and reputable data can be difficult at times. Providing sound evidenced based research is where a peer-reviewed journal can provide clarity. [...].

  19. Environmental Biosciences Program Quarterly Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  20. MUSC Environmental Biosciences Program First Quarter Report May - June, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr

    2002-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC02-98CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  1. Environmental Biosciences Program Third Quarter Report, Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  2. Scale dependence of open c anti c and b anti b production in the low x region

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, E.G. de [Universidade Federal de Santa Catarina, Departamento de Fisica, CFM, C.P. 476, Florianopolis, SC (Brazil); University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); Martin, A.D. [University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); Ryskin, M.G. [University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); NRC Kurchatov Institute, Petersburg Nuclear Physics Institute, St. Petersburg (Russian Federation)

    2017-03-15

    The 'optimal' factorization scale μ{sub 0} is calculated for open heavy quark production. We find that the optimal value is μ{sub F} = μ{sub 0} ≅ 0.85√(p{sup 2}{sub T}+m{sub Q}{sup 2}); a choice which allows us to resum the double-logarithmic, (α{sub s} ln μ{sup 2}{sub F} ln (1/x)){sup n} corrections (enhanced at LHC energies by large values of ln(1/x)) and to move them into the incoming parton distributions, PDF (x, μ{sub 0}{sup 2}). Besides this result for the single inclusive cross section (corresponding to an observed heavy quark of transverse momentum p{sub T}), we also determined the scale for processes where the acoplanarity can be measured; that is, events where the azimuthal angle between the quark and the antiquark may be determined experimentally. Moreover, we discuss the important role played by the 2 → 2 subprocesses, gg → Q anti Q at NLO and higher orders. In summary, we achieve a better stability of the QCD calculations, so that the data on c anti c and b anti b production can be used to further constrain the gluons in the small x, relatively low scale, domain, where the uncertainties of the global analyses are large at present. (orig.)

  3. An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA.

    Science.gov (United States)

    Thomas, K A; Valenzuela, N M; Gjertson, D; Mulder, A; Fishbein, M C; Parry, G C; Panicker, S; Reed, E F

    2015-08-01

    Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells. While F(ab')2 portions of DSA cause cellular activation and proliferation, Fc regions activate the classical complement cascade, resulting in complement deposition and leukocyte recruitment, both hallmark features of AMR. We characterized the ability of an anti-C1s monoclonal antibody, TNT003, to inhibit HLA antibody (HLA-Ab)-induced complement activation. Complement deposition induced by HLA-Ab was evaluated using novel cell- and bead-based assays. Human aortic endothelial cells (HAEC) were cultured with HLA-Ab and human complement; production of activated complement proteins was measured by flow cytometry. Additionally, C3d deposition was measured on single antigen beads (SAB) mixed with HLA-Ab and human complement. TNT003 inhibited HLA-Ab mediated complement deposition on HAEC in a concentration-dependent manner; C3a, C4a and C5a anaphylatoxin production was also diminished by TNT003. Finally, TNT003 blocked C3d deposition induced by Class I (HLAI-Ab)- and Class II (HLAII-Ab)-specific antibodies on SAB. These data suggest TNT003 may be useful for modulating the effects of DSA, as TNT003 inhibits complement deposition and split product formation generated by HLA-I/II-Ab in vitro. © 2015 The Authors. American Journal of Transplantation Published by Wiley Periodicals, Inc.

  4. The challenge of the Biosciences in Nurse Education: A literature review.

    Science.gov (United States)

    Jensen, Kari Toverud; Knutstad, Unni; Fawcett, Tonks N

    2018-03-25

    To review relevant literature that address the challenges of the biosciences in nurse education. More precisely the review aims to explore the literature, concerning students' learning, learning contexts and methodological issues and identify any significant gaps. Knowledge of anatomy, physiology and biochemistry are essential for the understanding of human beings and for full appreciation of the concepts of illness and disease. The current status would seem to be that the required competencies within bioscience subjects are difficult to acquire and students have high rates of failure. Integrative review. The research were performed on Cinahl, ERIC, Medline and British Nursing Index databases in a period from 2013 until 2017. Descriptive analytical methods were used for the initial research trawl. The search strategy resulted in 23 papers. The results of this review shed light on certain deficiencies in the research field looking at the biosciences in nurse education. There is a distinct lack of intervention studies, and thereby knowledge of how best to support students' learning in effective ways. Of note is that there are no field study approaches identified in the review sample. Many of the papers are single studies and course evaluations which may be seen as too narrow and inadequate a perspective. Students appear satisfied with the courses in the biosciences but there seems to be no correlation between satisfaction and achievement. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  5. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  6. Predictors of academic performance in the discipline-specific bioscience paper: a retrospective qualitative study.

    Science.gov (United States)

    Khareedi, R

    2018-05-01

    The cohort of students enrolled in the discipline-specific bioscience paper reflects a structural diversity in that it includes students of multiple ethnicities, varied age groups, differing scholastic and life experiences. These divergent identities of students are known to influence academic performance. The purpose of this retrospective quantitative study was to determine the ability of a set of variables such as age, gender, ethnicity, level of prior education, the place from which prior education was obtained, work experience and prior academic achievement to predict academic performance in the discipline-specific bioscience paper. The sample for this study was a purposive sample of all oral health students who had enrolled in the paper at the Auckland University of Technology from 2011 to 2014. The desensitised empirical data of 116 students from the University's database were subject to multivariable regression analysis. Pearson's correlation coefficients were calculated. Prior academic achievement was a statistically significant predictor variable (P academic performance in the discipline-specific bioscience paper and was also positively correlated (r = 0.641, P academic achievement was the only variable that was demonstrated to be correlated to and predictive of the academic performance in the discipline-specific bioscience paper. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. 77 FR 56175 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use)

    Science.gov (United States)

    2012-09-12

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration 21 CFR Part 573 [Docket No. FDA-2012-F-0949] Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use) AGENCY: Food... 573 Food Additives Permitted in Feed and Drinking Water of Animals (21 CFR part 573) to provide for...

  8. Automatic categorization of diverse experimental information in the bioscience literature

    Science.gov (United States)

    2012-01-01

    Background Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM). This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD). We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI). It is being used in the curation work flow at

  9. Automatic categorization of diverse experimental information in the bioscience literature

    Directory of Open Access Journals (Sweden)

    Fang Ruihua

    2012-01-01

    Full Text Available Abstract Background Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM. This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD. We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI. It is being used in

  10. Automatic categorization of diverse experimental information in the bioscience literature.

    Science.gov (United States)

    Fang, Ruihua; Schindelman, Gary; Van Auken, Kimberly; Fernandes, Jolene; Chen, Wen; Wang, Xiaodong; Davis, Paul; Tuli, Mary Ann; Marygold, Steven J; Millburn, Gillian; Matthews, Beverley; Zhang, Haiyan; Brown, Nick; Gelbart, William M; Sternberg, Paul W

    2012-01-26

    Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM). This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD). We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI). It is being used in the curation work flow at WormBase for

  11. The binding affinity of a soluble TCR-Fc fusion protein is significantly improved by crosslinkage with an anti-C{beta} antibody

    Energy Technology Data Exchange (ETDEWEB)

    Ozawa, Tatsuhiko; Horii, Masae; Kobayashi, Eiji [Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194 (Japan); Jin, Aishun [Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194 (Japan); Department of Immunology, College of Basic Medical Sciences, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150081 (China); Kishi, Hiroyuki, E-mail: immkishi@med.u-toyama.ac.jp [Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194 (Japan); Muraguchi, Atsushi [Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194 (Japan)

    2012-06-01

    Highlights: Black-Right-Pointing-Pointer A novel soluble TCR composed of TCR V and C regions with Ig Fc region is generated. Black-Right-Pointing-Pointer TCR-Fc protein immobilized by an anti-C{beta} antibody bound to a p/MHC tetramer. Black-Right-Pointing-Pointer Binding affinity of TCR-Fc was markedly increased by binding with anti-C{beta} antibody. -- Abstract: The identification and cloning of tumor antigen-specific T cell receptors (TCRs) and the production of the soluble form of the TCR (sTCR) contributed to the development of diagnostic and therapeutic tools for cancer. Recently, several groups have reported the development of technologies for the production of sTCRs. The native sTCR has a very low binding affinity for the antigenic peptide/MHC (p/MHC) complex. In this study, we established a technology to produce high affinity, functional sTCRs. We generated a novel sTCR-Fc fusion protein composed of the TCR V and C regions of the TCR linked to the immunoglobulin (Ig) Fc region. A Western blot analysis revealed that the molecular weight of the fusion protein was approximately 60 kDa under reducing conditions and approximately 100-200 kDa under non-reducing conditions. ELISAs using various antibodies showed that the structure of each domain of the TCR-Fc protein was intact. The TCR-Fc protein immobilized by an anti-C{beta} antibody effectively bound to a p/MHC tetramer. An SPR analysis showed that the TCR-Fc protein had a low binding affinity (KD; 1.1 Multiplication-Sign 10{sup -5} M) to the p/MHC monomer. Interestingly, when the TCR-Fc protein was pre-incubated with an anti-C{beta} antibody, its binding affinity for p/MHC increased by 5-fold (2.2 Multiplication-Sign 10{sup -6} M). We demonstrated a novel method for constructing a functional soluble TCR using the Ig Fc region and showed that the binding affinity of the functional sTCR-Fc was markedly increased by an anti-C{beta} antibody, which is probably due to the stabilization of the V

  12. Preface for the special issue of Mathematical Biosciences and Engineering, BIOCOMP 2012.

    Science.gov (United States)

    Buonocore, Aniello; Di Crescenzo, Antonio; Hastings, Alan

    2014-04-01

    The International Conference "BIOCOMP2012 - Mathematical Modeling and Computational Topics in Biosciences'', was held in Vietri sul Mare (Italy), June 4-8, 2012. It was dedicated to the Memory of Professor Luigi M. Ricciardi (1942-2011), who was a visionary and tireless promoter of the 3 previous editions of the BIOCOMP conference series. We thought that the best way to honor his memory was to continue the BIOCOMP program. Over the years, this conference promoted scientific activities related to his wide interests and scientific expertise, which ranged in various areas of applications of mathematics, probability and statistics to biosciences and cybernetics, also with emphasis on computational problems. We are pleased that many of his friends and colleagues, as well as many other scientists, were attracted by the goals of this recent event and offered to contribute to its success.

  13. Division of energy biosciences: Annual report and summaries of FY 1995 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

  14. C-kit-targeted imaging of gastrointestinal stromal tumor using radiolabeled anti-c-kit monoclonal antibody in a mouse tumor model

    International Nuclear Information System (INIS)

    Sogawa, Chizuru; Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Yoshida, Chisato; Odaka, Kenichi; Uehara, Tomoya; Arano, Yasushi; Koizumi, Mitsuru; Saga, Tsuneo

    2010-01-01

    Introduction: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor arising from the gastrointestinal tract and highly expresses mutated c-kit. We aimed to develop a specific and sensitive method for detecting GISTs using radiolabeled anti-c-kit monoclonal antibody. Methods: A mutated c-kit-expressing cell clone was established by transfecting an expressing vector of mutated c-kit gene into HEK293 human embryonic kidney cells. The tumors were developed by inoculating c-kit-expressing cells into nude mice. 125 I- and 111 In-labeled anti-c-kit antibodies (12A8 and 41A11) were evaluated in vitro by cell binding, competitive inhibition and cellular internalization assays, and in vivo by biodistribution and imaging studies in tumor-bearing mice. Results: Both 125 I- and 111 In-labeled antibodies showed specific binding with c-kit-expressing cells with high affinity (dissociation constants = 2.2-7.1x10 9 M -1 ). Internalization assay showed that 125 I-labeled antibodies were rapidly internalized and dehalogenated, with the release of 125 I from the cells, resulting in reduction of cell-associated radioactivity with time. In contrast, 111 In-labeled antibody was internalized but did not result in the reduced radioactivity associated with tumor cells. Reflecting this phenomenon, the in vivo tumor uptake of 125 I-labeled antibody was low on Day 1, further decreasing with time, while tumor uptake of 111 In-labeled antibody was high on Day 1, further increasing with time. The xenografted tumor was clearly visualized by scintigraphy after injection of 111 In-labeled antibody. Conclusion: The anti-c-kit monoclonal antibody labeled with a metal radionuclide would be promising for c-kit-targeted imaging of GISTs.

  15. An acute hemolytic transfusion reaction due to the "anti-c" rhesus antibody: A case report emphasizing the role of transfusion medicine

    Directory of Open Access Journals (Sweden)

    Deepti Sachan

    2015-01-01

    Full Text Available Rhesus (Rh mediated hemolytic transfusion reactions (HTR are usually immunoglobulin G mediated and delayed onset. Rh antibodies being the cause of acute HTR (AHTR and intravascular hemolysis are still under debate. We report here a case of a 53-year-old male who developed AHTR due to "anti-c" antibodies within 3 h of blood transfusion, precipitating fatal acute liver failure in a patient with hepatitis C related chronic liver disease. This case emphasizes the need of inclusion of antibody screening in routine pretransfusion testing as well as a critical role of transfusion medicine specialists for early diagnosis and minimizing transfusion-related morbidity and mortality.

  16. Studies on middle silkgland proteins of cocoon colour sex-limited ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences; Volume 29; Issue 1. Studies on middle silkgland proteins of cocoon colour sex-limited silkworm (Bombyx mori L.) using two-dimensional polyacrylamide gel electrophoresis. Yuan-Xiang Jin Yu-Yin Chen Meng-Kui Xu Yong-Huang Jiang. Articles Volume 29 Issue 1 March 2004 pp 45- ...

  17. Can active learning principles be applied to the bioscience assessments of nursing students? A review of the literature.

    Science.gov (United States)

    Bakon, Shannon; Craft, Judy; Christensen, Martin; Wirihana, Lisa

    2016-02-01

    To explore if active learning principles be applied to nursing bioscience assessments and will this influence student perception of confidence in applying theory to practice? A review of the literature utilising searches of various databases including CINAHL, PUBMED, Google Scholar and Mosby's Journal Index. The literature search identified research from twenty-six original articles, two electronic books, one published book and one conference proceedings paper. Bioscience has been identified as an area that nurses struggle to learn in tertiary institutions and then apply to clinical practice. A number of problems have been identified and explored that may contribute to this poor understanding and retention. University academics need to be knowledgeable of innovative teaching and assessing modalities that focus on enhancing student learning and address the integration issues associated with the theory practice gap. Increased bioscience education is associated with improved patient outcomes therefore by addressing this "bioscience problem" and improving the integration of bioscience in clinical practice there will subsequently be an improvement in health care outcomes. From the literature several themes were identified. First there are many problems with teaching nursing students bioscience education. These include class sizes, motivation, concentration, delivery mode, lecturer perspectives, student's previous knowledge, anxiety, and a lack of confidence. Among these influences the type of assessment employed by the educator has not been explored or identified as a contributor to student learning specifically in nursing bioscience instruction. Second that educating could be achieved more effectively if active learning principles were applied and the needs and expectations of the student were met. Lastly, assessment influences student retention and the student experience and as such assessment should be congruent with the subject content, align with the learning

  18. Twin pregnancy complicated by severe hemolytic disease of the fetus and newborn due to anti-g and anti-C.

    Science.gov (United States)

    Trevett, Thomas N; Moise, Kenneth J

    2005-11-01

    Hemolytic disease of the fetus and newborn caused by anti-G antibodies is rare, and in most previously reported cases, leads to a mild anemia. The RhG antigen is usually found in association with both RhD and RhC. We report a case of a twin pregnancy affected by both anti-G and anti-C alloantibodies leading to severe hemolytic disease of the fetus and newborn requiring multiple intrauterine transfusions and prolonged postnatal therapy. A patient with a prolonged history of previously affected pregnancies due to anti-D and anti-C was subsequently found to be affected with anti-G instead. She required aggressive therapy during her pregnancy, initially with intravenous immune globulin and plasmapheresis until umbilical blood sampling and intrauterine transfusions were feasible. Although hemolytic disease of the fetus and newborn due to anti-G antibodies is rare and usually mild, these pregnancies should be followed up closely and in utero therapy should be offered if necessary.

  19. Reduction in erythrocyte-bound complement activation products and titres of anti-C1q antibodies associate with clinical improvement in systemic lupus erythematosus.

    Science.gov (United States)

    Buyon, Jill; Furie, Richard; Putterman, Chaim; Ramsey-Goldman, Rosalind; Kalunian, Kenneth; Barken, Derren; Conklin, John; Dervieux, Thierry

    2016-01-01

    The relationship between cell-bound complement activation products (CB-CAPs: EC4d, EC3d), anti-C1q, soluble complement C3/C4 and disease activity in systemic lupus erythematosus (SLE) was evaluated. Per protocol, at baseline all SLE subjects enrolled in this longitudinal study presented with active disease and elevated CB-CAPs. At each monthly visit, the non-serological (ns) Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA-SLEDAI) and the British Isles Lupus Assessment Group (BILAG)-2004 index scores were determined as was a random urinary protein to creatinine ratio (uPCR). Short-form 36 (SF-36) questionnaires were also collected. All soluble markers were determined using immunoassays, while EC4d and EC3d were determined using flow cytometry. Statistical analysis consisted of linear mixed models with random intercept and fixed slopes. A total of 36 SLE subjects (mean age 34 years; 94% female) were enrolled and evaluated monthly for an average 11 visits per subject. Clinical improvements were observed during the study, with significant decreases in ns-SELENA-SLEDAI scores, BILAG-2004 index scores and uPCR, and increases in all domains of SF-36 (pimprovements in at least six out of the eight domains of SF-36 and outperformed C3/C4. Anti-dsDNA titres did not correlate with changes in disease activity. These data indicate that CB-CAPs and anti-C1q are helpful in monitoring patients with SLE.

  20. Mass spectrum of spin-1/2 pentaquarks with a c anti c component and their anticipated discovery modes in b-baryon decays

    Energy Technology Data Exchange (ETDEWEB)

    Ali, Ahmed [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Ahmed, Ishtiaq; Rehman, Abdur [Quaid-i-Azam University Campus, Islamabad (Pakistan). National Centre for Physics; Aslam, M. Jamil [Quaid-i-Azam University, Islamabad (Pakistan). Physics Dept.

    2017-04-15

    The LHCb discovery of the two baryonic states P{sub c}{sup +}(4380) and P{sub c}{sup +}(4450), having J{sup P}=3/2{sup -} and J{sup P}=5/2{sup +}, respectively, in the process pp → b anti b → Λ{sub b}X, followed by the decay Λ{sub b}→J/ψpK{sup -}, has motivated a number of theoretical models. Interpreting them as compact { anti c[cu][ud]; L_P=0,1} objects, the mass spectroscopy of the J{sup P}=3/2{sup -} and J{sup P}=5/2{sup +} pentaquarks was worked out by us for the pentaquarks in the SU(3){sub F} multiplets, using an effective Hamiltonian based on constituent diquarks and quarks. Their possible discovery modes in b-baryon decays were also given using the heavy quark spin symmetry. In this paper, we calculate the mass spectrum of the hidden c anti c pentaquarks having J{sup P}=(1)/(2){sup ±} for the SU(3){sub F} multiplets and their anticipated discovery modes in b-baryon decays. Some of the P{sub c}{sup +}(J{sup P}=1/2{sup ±}) pentaquarks, produced in the Λ{sub b} decays may have their masses just below the J/ψ p threshold, in which case they should be searched for in the modes P{sub c}{sup +}(J{sup P}=1/2{sup ±})→η{sub c}p,μ{sup +}μ{sup -}p,e{sup +}e{sup -}p.

  1. Division of Energy Biosciences annual report and summaries of FY 1996 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.

  2. Ontologies and standards in bioscience research: for machine or for human

    Directory of Open Access Journals (Sweden)

    Huaiyu eMi

    2011-02-01

    Full Text Available Ontologies and standards are very important parts of today’s bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to manage and analyze the data. Most of these standards are initially designed for computers to access large amounts of data that are difficult for human biologists to handle, and it is important to keep in mind that ultimately biologists are going to produce and interpret the data. While ontologies and standards must follow strict semantic rules that may not be familiar to biologists, effort must be spent to lower the learning barrier by involving biologists in the process of development, and by providing software and tool support. A standard will not succeed without support from the wider bioscience research community. Thus, it is crucial that these standards be designed not only for machines to read, but also to be scientifically accurate and intuitive to human biologists.

  3. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences

    Science.gov (United States)

    King, Nicola C.; Aves, Stephen J.

    2012-01-01

    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  4. Novel anti-c-Mpl monoclonal antibodies identified multiple differentially glycosylated human c-Mpl proteins in megakaryocytic cells but not in human solid tumors.

    Science.gov (United States)

    Zhan, Jinghui; Felder, Barbara; Ellison, Aaron R; Winters, Aaron; Salimi-Moosavi, Hossein; Scully, Sheila; Turk, James R; Wei, Ping

    2013-06-01

    Thrombopoietin and its cognate receptor, c-Mpl, are the primary molecular regulators of megakaryocytopoiesis and platelet production. To date the pattern of c-Mpl expression in human solid tumors and the distribution and biochemical properties of c-Mpl proteins in hematopoietic tissues are largely unknown. We have recently developed highly specific mouse monoclonal antibodies (MAb) against human c-Mpl. In this study we used these antibodies to demonstrate the presence of full-length and truncated human c-Mpl proteins in various megakaryocytic cell types, and their absence in over 100 solid tumor cell lines and in the 12 most common primary human tumor types. Quantitative assays showed a cell context-dependent distribution of full-length and truncated c-Mpl proteins. All forms of human c-Mpl protein were found to be modified with extensive N-linked glycosylation but different degrees of sialylation and O-linked glycosylation. Of note, different variants of full-length c-Mpl protein exhibiting differential glycosylation were expressed in erythromegakaryocytic leukemic cell lines and in platelets from healthy human donors. This work provides a comprehensive analysis of human c-Mpl mRNA and protein expression on normal and malignant hematopoietic and non-hematopoietic cells and demonstrates the multiple applications of several novel anti-c-Mpl antibodies.

  5. A preliminary exploration of Advanced Molecular Bio-Sciences Research Center

    International Nuclear Information System (INIS)

    Yamada, Yutaka; Yanai, Takanori; Onodera, Jun'ichi; Yamagami, Mutsumi; Sakata, Hiroshi; Sota, Masahiro; Takemura, Tatsuo; Koyama, Kenji; Sato, Fumiaki

    2000-01-01

    Low-dose and low-dose-rate radiation effects on life-span, pathological changes, hemopoiesis and cytokine production in experimental animals have been investigated in our laboratory. In the intermediate period of the investigation, an expert committee on radiation biology, which was composed of two task groups, was organized. The purposes of the committee were to assess of previous studies and plan future research for Advanced Molecular Bio-Sciences Research Center (AMBIC). In its report, the committee emphasized the necessity of molecular research in radiation biology and ecology, and proposed six subjects for the research: 1) Molecular carcinogenesis of low-dose radiation; 2) Radiation effects on the immune system and hemopoietic system; 3) Molecular mechanisms of hereditary effect; 4) Non cancer effect of low-dose radiation; 5) Gene targeting for ion transport system in plants; 6) Bioremediation with transgenic plant and bacteria. Exploration of the AMBIC project will continue under the committee's direction. (author)

  6. Assessment of Collaboration and Interoperability in an Information Management System to Support Bioscience Research

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L.

    2009-01-01

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C4I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the “must have” attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation. PMID:20351900

  7. A preliminary exploration of the advanced molecular bio-sciences research center

    International Nuclear Information System (INIS)

    Yanai, Takanori; Yamada, Yutaka; Tanaka, Kimio; Yamagami, Mutsumi; Sota, Masahiro; Takemura, Tatsuo; Koyama, Kenji; Sato, Fumiaki

    2001-01-01

    Low dose and low dose rate radiation effects on lifespan, pathological changes, hemopoiesis and cytokine production in mice have been investigated in our laboratory. In the intermediate period of the investigation, an expert committee on radiation biology was organized. The purposes of the committee were to assess previous studies and advise on a future research plan for the Advanced Molecular Bio-Sciences Research Center (AMBIC). The committee emphasized the necessity of molecular research in radiation biology, and proposed the following five subjects: 1) molecular carcinogenesis by low dose radiation; 2) radiation effects on the immune and hemopoietic systems; 3) molecular mechanisms of hereditary effect; 4) noncancer diseases of low dose radiation, and 5) cellular mechanisms by low dose radiation. (author)

  8. Contentious problems in bioscience and biotechnology: a pilot study of an approach to ethics education.

    Science.gov (United States)

    Berry, Roberta M; Borenstein, Jason; Butera, Robert J

    2013-06-01

    This manuscript describes a pilot study in ethics education employing a problem-based learning approach to the study of novel, complex, ethically fraught, unavoidably public, and unavoidably divisive policy problems, called "fractious problems," in bioscience and biotechnology. Diverse graduate and professional students from four US institutions and disciplines spanning science, engineering, humanities, social science, law, and medicine analyzed fractious problems employing "navigational skills" tailored to the distinctive features of these problems. The students presented their results to policymakers, stakeholders, experts, and members of the public. This approach may provide a model for educating future bioscientists and bioengineers so that they can meaningfully contribute to the social understanding and resolution of challenging policy problems generated by their work.

  9. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience.

    Science.gov (United States)

    Aicardi, Christine

    2016-02-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a 'cross-worlds influencer' who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise 'un-disciplined' new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against 'vitalism': anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of 'doing science' and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: 'follow the cross-worlds influencers' who worked to build and organise these semi-institutional gatherings and institutional structures. Copyright © 2015 The Author. Published by Elsevier Ltd.. All rights reserved.

  10. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience

    Science.gov (United States)

    Aicardi, Christine

    2016-01-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a ‘cross-worlds influencer’ who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise ‘un-disciplined’ new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against ‘vitalism’: anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of ‘doing science’ and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: ‘follow the cross-worlds influencers’ who worked to build and organise these semi-institutional gatherings and institutional structures. PMID:26383132

  11. Development of positron emission tomography probe of 64Cu-labeled anti-C-kit 12A8 Fab to measure protooncogene C-kit expression

    International Nuclear Information System (INIS)

    Yoshida, Chisato; Tsuji, Atsushi B.; Sudo, Hitomi; Sugyo, Aya; Sogawa, Chizuru; Inubushi, Masayuki; Uehara, Tomoya; Fukumura, Toshimitsu; Koizumi, Mitsuru; Arano, Yasushi; Saga, Tsuneo

    2011-01-01

    Introduction: C-kit is an important diagnostic and therapeutic target molecule for several malignancies, and c-kit-targeted drugs have been used clinically. Because abundant c-kit expression in tumors is a prerequisite for successful c-kit-targeted therapy, imaging of c-kit expression is expected to play a pivotal role in the therapeutic decision for each patient. We evaluated 64 Cu-labeled Fab of anti-c-kit antibody 12A8 as a positron emission tomography (PET) imaging probe. Methods: 111 In- or 125 I-Labeled 12A8 Fab was evaluated in vitro by cell binding, competitive inhibition and cellular internalization assays, and in vivo by biodistribution in mice bearing c-kit-expressing and -non-expressing tumors. Next, Fab fragment was labeled with the positron emitter 64 Cu and evaluated by PET. Results: Radiolabeled 12A8 Fab showed specific binding to c-kit-expressing cells with high affinity and internalized into cells after binding to c-kit on cell surface. Although tumor accumulation of [ 111 In]Fab was lower than that of [ 111 In]IgG, the faster blood clearance of [ 111 In]Fab provided higher tumor-to-blood ratio at 6 h postinjection onwards. Blood clearance of 64 Cu-labeled 12A8 Fab was slower than that of [ 111 In]Fab, but PET using [ 64 Cu]Fab clearly visualized the tumor at 6 h postinjection onwards. Conclusion: The 64 Cu-labeled 12A8 Fab could be used for c-kit-specific PET imaging and might help in selecting appropriate patients for c-kit-targeted treatments.

  12. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    International Nuclear Information System (INIS)

    1991-09-01

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab

  13. An Internship May Not Be Enough: Enhancing Bioscience Industry Job Readiness through Practicum Experiences

    Directory of Open Access Journals (Sweden)

    Jason M. Cramer

    2017-05-01

    Full Text Available In contrast to the narrowing of options in academic careers, the bioscience industry offers robust employment opportunities for STEM-trained workers, especially those who display both scientific and business talent. Unfortunately, traditional science programs typically lack curricular features that develop this type of worker. The North Carolina State University Master of Microbial Biotechnology (MMB program facilitates industry-specific experiential learning to fill this training gap. Similar programs often rely on a single industry internship to provide students relevant work experience, but completion of one internship might not suffice to position students for employment in a highly competitive job market. The MMB program requires students to complete an internship and three practicum projects in an industry setting, to promote development of key skills in a variety of areas, to build confidence in the ability to perform initial job duties, and to establish a more extensive work history in industry. In this Perspective we discuss an unmet need in undergraduate and graduate STEM education that can be filled by incorporating a similar set of industry-specific work experiences for students who desire to transition from academe into the life science industry.

  14. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab (MHB)

  15. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends; SBBN 2010: 7. Congresso da Sociedade Brasileira de Biociencias Nucleares. Radiacoes em biociencias: avancos e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  16. A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

    Directory of Open Access Journals (Sweden)

    Quail Michael A

    2012-07-01

    Full Text Available Abstract Background Next generation sequencing (NGS technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’ RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. Results Sequence generated by Ion Torrent, MiSeq and Pacific Biosciences technologies displays near perfect coverage behaviour on GC-rich, neutral and moderately AT-rich genomes, but a profound bias was observed upon sequencing the extremely AT-rich genome of Plasmodium falciparum on the PGM, resulting in no coverage for approximately 30% of the genome. We analysed the ability to call variants from each platform and found that we could call slightly more variants from Ion Torrent data compared to MiSeq data, but at the expense of a higher false positive rate. Variant calling from Pacific Biosciences data was possible but higher coverage depth was required. Context specific errors were observed in both PGM and MiSeq data, but not in that from the Pacific Biosciences platform. Conclusions All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support.

  17. Bioscience-bioethics and life factors affecting reproduction with special reference to the Indigenous Australian population.

    Science.gov (United States)

    Pollard, Irina

    2005-04-01

    The demand for equality of recognition or respect is the dominant passion of modernity. The 20th century experienced a giant leap in technological inventiveness and ruthless use of technological power. In the 21st century, human welfare and environmental wellbeing demand fundamental political appraisal. We have the means, if we choose, to eradicate poverty and to responsibly protect the global environment. However, economic, political and cultural systems act to differentially allocate the benefits and risks for growth between socioeconomic groups. For example, it is a matter of pride that the neonatal mortality rate in affluent societies has dropped substantially since the late 1970s. However, the level of infant mortality (three times the national average) and low birthweight (13%) among the Indigenous Australian population is the highest in the country. With hindsight we now know that is the inevitable legacy of Australia's colonial history. Chronic physical and psychological stress is recognized as an important etiological factor in many lifestyle diseases of the cardiovascular, immune and reproductive systems. Diseases of adaptation are further advanced by non-adaptive lifestyle choices, depression, alcoholism and other drug dependencies. This review describes the principles of bioscience ethics and targets equity issues as they affect human reproduction across generations with particular reference to the Indigenous population of Australia. The review also considers ways we may advance global and cultural maturity from the Indigenous Australian perspective and proposes an ecologically based model of preventative care. If we are to embrace fundamental social change and protect future children without threatening parents' basic freedoms, then new beliefs and priorities--based on a compassionate understanding of biological systems--must evolve from the general public. Belief in human rights arising from a sense of human dignity is a collective outcome originating

  18. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  19. Harnessing the power of communities: career networking strategies for bioscience PhD students and postdoctoral researchers.

    Science.gov (United States)

    Blackford, Sarah

    2018-04-01

    With an ever more competitive global labour market, coupled with an ever-increasing population of PhD-qualified graduates, the ability to communicate effectively and build strategic connections with others can be advantageous in the job-search process. Whether in pursuit of a tenure-track or non-academic position, many postdoctoral researchers and PhD students will benefit from networking as early as possible to enhance their career prospects. Sometimes viewed cynically as 'using people' or dismissed as 'the old boy network,' the ability to make meaningful connections and build relationships can be more valuable than other job-related skills in order to gain entry to, and progress within, many professions. This mini-review highlights the positive influence of networking and how bioscience PhD students and postdoctoral researchers can harness the power of communities to achieve career success. It is argued that those who make connections and promote personal patronage through networking can gain an advantage over their contemporaries. A summary of key theories and research studies that underpin the practice of networking provides credence to these assertions, which are further substantiated with examples pertinent to the academic community. Although primarily focussed on the biosciences, much of the content is applicable to other scientists at a similar career stage.

  20. Gateway to the Future. Skill Standards for the Bioscience Industry for Technical Workers in Pharmaceutical Companies, Biotechnology Companies, and Clinical Laboratories.

    Science.gov (United States)

    Education Development Center, Inc., Newton, MA.

    The Bioscience Industry Skills Standards Project (BISSP) is developing national, voluntary skill standards for technical jobs in biotechnology and pharmaceutical companies and clinical laboratories in hospitals, universities, government, and independent settings. Research with employees and educators has pinpointed three issues underscoring the…

  1. Veneno para la mente: La participación de los especialistas en salud mental en la campaña anti-cómic estadounidense (1940-1960)

    OpenAIRE

    Fernández Sarasola, Ignacio

    2016-01-01

    Entre 1940 y 1960 se desarrolló en Estados Unidos una intensa campaña anti-cómic impulsada por ciudadanos que consideraban que aquellas revistas no solo suponían una mala influencia para sus niños, sino que eran responsables de un incremento en la delincuencia juvenil. Un punto de inflexión se produjo en el momento en que psiquiatras y psicólogos se incorporaron a la citada campaña. Su líder fue Fredric Wertham, un psiquiatra de origen germano que acusó a los cómics de dañar la mente de los n...

  2. Limiting factors in the production of deep microstructures

    Science.gov (United States)

    Tolfree, David W. L.; O'Neill, William; Tunna, Leslie; Sutcliffe, Christopher

    1999-10-01

    Microsystems increasingly require precision deep microstructures that can be cost-effectively designed and manufactured. New products must be able to meet the demands of the rapidly growing markets for microfluidic, micro- optical and micromechanical devices in industrial sectors which include chemicals, pharmaceuticals, biosciences, medicine and food. The realization of such products, first requires an effective process to design and manufacture prototypes. Two process methods used for the fabrication of high aspect-ratio microstructures are based on X-ray beam lithography with electroforming processes and direct micromachining with a frequency multiplied Nd:YAG laser using nanosecond pulse widths. Factors which limit the efficiency and precision obtainable using such processes are important parameters when deciding on the best fabrication method to use. A basic microstructure with narrow channels suitable for a microfluidic mixer have been fabricated using both these techniques and comparisons made of the limitations and suitability of the processes in respect of fast prototyping and manufacture or working devices.

  3. Reflective writing as a tool for assessing teamwork in bioscience: insights into student performance and understanding of teamwork.

    Science.gov (United States)

    Mayne, Lynne

    2012-07-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly evolving competitive work place and align with the needs of industry. This creates a challenge, how do we develop generic capabilities without losing discipline content. This report analyses teamwork projects embedded in an undergraduate Biotechnology degree designed to promote teamwork skills along with a deeper understanding of the underpinning biochemistry. Student reflective writing was used to capture students' understanding and experience of teamwork as well as provide insight into their metacognition. The analysis demonstrates that 73% of Year 3 and 93% of Year 4 students were capable of learning about teamwork through reflective writing. While the importance of frequent high quality communication was a common theme, evidence suggests that many students were unsophisticated in their use of communication software. The analysis also highlighted the depth of metacognition that underpins successful team function and the significant weaknesses in self-insight some students possess. These findings challenge assumptions regarding student capacity for leadership and the ability of some students to contribute to successful team outcomes. It is essential for the design of teamwork experiences to fully understand the competencies that underlie teamwork, the metacognitive processes required, and ensure that assessments are fair and measure individual academic performance. Copyright © 2012 Wiley Periodicals, Inc.

  4. Current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States). Systems Surety Assessment Dept.; Noren, K. [Univ. of Idaho, Moscow, ID (United States). Dept. of Electrical Engineering

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  5. Quench limits

    International Nuclear Information System (INIS)

    Sapinski, M.

    2012-01-01

    With thirteen beam induced quenches and numerous Machine Development tests, the current knowledge of LHC magnets quench limits still contains a lot of unknowns. Various approaches to determine the quench limits are reviewed and results of the tests are presented. Attempt to reconstruct a coherent picture emerging from these results is taken. The available methods of computation of the quench levels are presented together with dedicated particle shower simulations which are necessary to understand the tests. The future experiments, needed to reach better understanding of quench limits as well as limits for the machine operation are investigated. The possible strategies to set BLM (Beam Loss Monitor) thresholds are discussed. (author)

  6. Asociación del anticuerpo anti-C1q con las manifestaciones clínicas, hematológicas e inmunológicas en el Lupus Eritematoso Sistémico : Estudio observacional retrospectivo de 135 casos.

    OpenAIRE

    Córica, María Emilia

    2012-01-01

    : Las concentraciones de anticuerpo anti-C1q están elevadas en los pacientes afectados de LES. Según algunos estudios la presencia de este anticuerpo está asociada a la nefropatía lúpica, sin embargo en otros estudios esta relación no se comprobó. En nuestro trabajo relacionamos la positividad del anticuerpo anti-C1q con las manifestaciones clínicas, hematológicas e inmunológicas de la enfermedad. A diferencia de estudios previos sólo pudimos establecer una relación estadísticamente significa...

  7. Dose limits

    International Nuclear Information System (INIS)

    Fitoussi, L.

    1987-12-01

    The dose limit is defined to be the level of harmfulness which must not be exceeded, so that an activity can be exercised in a regular manner without running a risk unacceptable to man and the society. The paper examines the effects of radiation categorised into stochastic and non-stochastic. Dose limits for workers and the public are discussed

  8. Inverse Limits

    CERN Document Server

    Ingram, WT

    2012-01-01

    Inverse limits provide a powerful tool for constructing complicated spaces from simple ones. They also turn the study of a dynamical system consisting of a space and a self-map into a study of a (likely more complicated) space and a self-homeomorphism. In four chapters along with an appendix containing background material the authors develop the theory of inverse limits. The book begins with an introduction through inverse limits on [0,1] before moving to a general treatment of the subject. Special topics in continuum theory complete the book. Although it is not a book on dynamics, the influen

  9. Navigating Bioethical Waters: Two Pilot Projects in Problem-Based Learning for Future Bioscience and Biotechnology Professionals.

    Science.gov (United States)

    Berry, Roberta M; Levine, Aaron D; Kirkman, Robert; Blake, Laura Palucki; Drake, Matthew

    2016-12-01

    We believe that the professional responsibility of bioscience and biotechnology professionals includes a social responsibility to contribute to the resolution of ethically fraught policy problems generated by their work. It follows that educators have a professional responsibility to prepare future professionals to discharge this responsibility. This essay discusses two pilot projects in ethics pedagogy focused on particularly challenging policy problems, which we call "fractious problems". The projects aimed to advance future professionals' acquisition of "fractious problem navigational" skills, a set of skills designed to enable broad and deep understanding of fractious problems and the design of good policy resolutions for them. A secondary objective was to enhance future professionals' motivation to apply these skills to help their communities resolve these problems. The projects employed "problem based learning" courses to advance these learning objectives. A new assessment instrument, "Skills for Science/Engineering Ethics Test" (SkillSET), was designed and administered to measure the success of the courses in doing so. This essay first discusses the rationale for the pilot projects, and then describes the design of the pilot courses and presents the results of our assessment using SkillSET in the first pilot project and the revised SkillSET 2.0 in the second pilot project. The essay concludes with discussion of observations and results.

  10. 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.

    Science.gov (United States)

    Nelson, Christopher J; Ausió, Juan

    2012-06-01

    The 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability in Whistler, Canada, 14-18 March 2012, brought together 31 speakers from different nationalities. The organizing committee, led by Jim Davie (Chair) at the University of Manitoba (Manitoba, Canada), consisted of several established researchers in the fields of chromatin and epigenetics from across Canada. The meeting was centered on the contribution of epigenetics to gene expression, DNA damage and repair, and the role of environmental factors. A few interesting talks on replication added some insightful information on the controversial issue of histone post-translational modifications as genuine epigenetic marks that are inherited through cell division.

  11. Journal of Biosciences | News

    Indian Academy of Sciences (India)

    2008-07-05

    Jul 5, 2008 ... This last part of surgery, namely, operations, is a reflection on the healing art; it is a tacit acknowledgement of the insufficiency of surgery. It is like an armed savage who attempts to get that by force which a civilised man would get by stratagem.

  12. Journal of Biosciences

    Indian Academy of Sciences (India)

    Unknown

    Increasing population and declining biological resources in the context of global change ... growth hormone from Indian catfish (Heteropneustes fossilis). 315. Chalcolithic ..... Medically assisted reproductive technology. Molecular insights into ...

  13. Journal of Biosciences

    Indian Academy of Sciences (India)

    tribpo

    Antiserum directed against cell surface antigens ... lating antigen in bancroftian filariasis. 229 ... Tissue specific compartmental analysis of gonado- ..... Prostate. Effect of luteinizing hormone releasing hormone analogues on testosterone ...

  14. Communication skills for biosciences

    National Research Council Canada - National Science Library

    Dawson, Maureen M; Dawson, Brian A; Overfield, J

    2010-01-01

    ... Referencing conventions The Harvard style of referencing Quotations and how to cite and reference them Using software to generate your references Examples of citations and references References Further reading 23 23 23 28 29 30 31 42 43 44 45 47 48 48 59 60viii CONTENTS 3 Essay Writing About this chapter The purpose of assignments Why wri...

  15. Tutorials in mathematical biosciences

    CERN Document Server

    2008-01-01

    The book offers an easy introduction to fast growing research areas in evolution of species, population genetics, ecological models, and population dynamics. The first two chapters review the concept and methodologies of phylogenetic trees; computational schemes and illustrations are given, including applications such as tracing the origin of SARS and influenza. The third chapter introduces the reader to ecological models, including predator-prey models. This chapter includes and introduction to reaction-diffusion equations, which are used to analyze the ecological models. The next chapter reviews a broad range of ongoing research in population dynamics, including evolution of dispersal models; it also features interesting mathematical theorems and lists open problems. The final chapter deals with gene frequencies under the action of migration and selection. The book is addressed to readers at the level of grad students and researchers. A background in PDEs is provided.

  16. Journal of Biosciences

    Indian Academy of Sciences (India)

    Unknown

    Antibiotic. A non-polyene antifungal antibiotic from Streptomyces albido- flavus PU 23 ... Nutrients and toxin producing phytoplankton control algal blooms – a spatio-temporal .... sion: Ecological aspects of animal development. 65. Ecology.

  17. Approximation for limit cycles and their isochrons.

    Science.gov (United States)

    Demongeot, Jacques; Françoise, Jean-Pierre

    2006-12-01

    Local analysis of trajectories of dynamical systems near an attractive periodic orbit displays the notion of asymptotic phase and isochrons. These notions are quite useful in applications to biosciences. In this note, we give an expression for the first approximation of equations of isochrons in the setting of perturbations of polynomial Hamiltonian systems. This method can be generalized to perturbations of systems that have a polynomial integral factor (like the Lotka-Volterra equation).

  18. Interactive problem-solving sessions in an introductory bioscience course engaged students and gave them feedback, but did not increase their exam scores.

    Science.gov (United States)

    McEvoy, James P

    2017-10-02

    Active learning, including the promotion of student interactivity in lectures, has been found to improve student engagement and performance in university science classes. This letter describes the use of Pearson's Learning Catalytics to run regular, formatively assessed problem-solving sessions as part of the semiflipped redesign of an introductory level university bioscience course. Students found the problem-solving sessions more engaging than a traditional lecture, and felt that they were receiving better feedback on their progress in the course. Their participation in the problem-solving sessions was strongly associated with their performance in the course's summative assessments, making it possible to identify and assist probable poor performers early in the course. Other measures of student engagement with the course were not improved, and neither were their average exam grades when compared with their grades in a course which had not been redesigned. Possible reasons for this are discussed. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. The Beamline X28C of the Center for Synchrotron Biosciences: a National Resource for Biomolecular Structure and Dynamics Experiments Using Synchrotron Footprinting

    International Nuclear Information System (INIS)

    Gupta, S.; Sullivan, M.; Toomey, J.; Kiselar, J.; Chance, M.

    2007-01-01

    Structural mapping of proteins and nucleic acids with high resolution in solution is of critical importance for understanding their biological function. A wide range of footprinting technologies have been developed over the last ten years to address this need. Beamline X28C, a white-beam X-ray source at the National Synchrotron Light Source of Brookhaven National Laboratory, functions as a platform for synchrotron footprinting research and further technology development in this growing field. An expanding set of user groups utilize this national resource funded by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health. The facility is operated by the Center for Synchrotron Biosciences and the Center for Proteomics of Case Western Reserve University. The facility includes instrumentation suitable for conducting both steady-state and millisecond time-resolved footprinting experiments based on the production of hydroxyl radicals by X-rays. Footprinting studies of nucleic acids are routinely conducted with X-ray exposures of tens of milliseconds, which include studies of nucleic acid folding and their interactions with proteins. This technology can also be used to study protein structure and dynamics in solution as well as protein-protein interactions in large macromolecular complexes. This article provides an overview of the X28C beamline technology and defines protocols for its adoption at other synchrotron facilities. Lastly, several examples of published results provide illustrations of the kinds of experiments likely to be successful using these approaches

  20. Partnerships – Limited partnerships and limited liability limited partnerships

    OpenAIRE

    Henning, Johan J.

    2000-01-01

    Consideration of the Limited Liability Partnership Act 2000 which introduced a new corporate entity, carrying the designations “partnership” and “limited” which allow members to limit their liability whilst organising themselves internally as a partnership. Article by Professor Johan Henning (Director of the Centre for Corporate Law and Practice, IALS and Dean of the Faculty of Law, University of the Free State, South Africa). Published in Amicus Curiae - Journal of the Institute of Advanced ...

  1. HOME Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — HOME Income Limits are calculated using the same methodology that HUD uses for calculating the income limits for the Section 8 program. These limits are based on HUD...

  2. Limits on fundamental limits to computation.

    Science.gov (United States)

    Markov, Igor L

    2014-08-14

    An indispensable part of our personal and working lives, computing has also become essential to industries and governments. Steady improvements in computer hardware have been supported by periodic doubling of transistor densities in integrated circuits over the past fifty years. Such Moore scaling now requires ever-increasing efforts, stimulating research in alternative hardware and stirring controversy. To help evaluate emerging technologies and increase our understanding of integrated-circuit scaling, here I review fundamental limits to computation in the areas of manufacturing, energy, physical space, design and verification effort, and algorithms. To outline what is achievable in principle and in practice, I recapitulate how some limits were circumvented, and compare loose and tight limits. Engineering difficulties encountered by emerging technologies may indicate yet unknown limits.

  3. Robust test limits

    NARCIS (Netherlands)

    Albers, Willem/Wim; Kallenberg, W.C.M.; Otten, G.D.

    1997-01-01

    Because of inaccuracies of the measurement process inspection of manufactured parts requires test limits which are more strict than the given specification limits. Test limits derived under the assumption of normality for product characteristics turn out to violate the prescribed bound on the

  4. LANSCE beam current limiter

    International Nuclear Information System (INIS)

    Gallegos, F.R.

    1996-01-01

    The Radiation Security System (RSS) at the Los Alamos Neutron Science Center (LANSCE) provides personnel protection from prompt radiation due to accelerated beam. Active instrumentation, such as the Beam Current Limiter, is a component of the RSS. The current limiter is designed to limit the average current in a beam line below a specific level, thus minimizing the maximum current available for a beam spill accident. The beam current limiter is a self-contained, electrically isolated toroidal beam transformer which continuously monitors beam current. It is designed as fail-safe instrumentation. The design philosophy, hardware design, operation, and limitations of the device are described

  5. 7 CFR 1400.204 - Limited partnerships, limited liability partnerships, limited liability companies, corporations...

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Limited partnerships, limited liability partnerships..., limited liability partnerships, limited liability companies, corporations, and other similar legal entities. (a) A limited partnership, limited liability partnership, limited liability company, corporation...

  6. JET pump limiter

    International Nuclear Information System (INIS)

    Sonnenberg, K.; Deksnis, E.; Shaw, R.; Reiter, D.

    1988-01-01

    JET plans to install two pump limiter modules which can be used for belt-limiter, inner-wall and X-point discharges and, also, for 1-2s as the main limiter. A design is presented which is compatible with two diagnostic systems, and which allows partial removal of the pump limiter to provide access for remote-handling operations. The high heat-flux components are initially cooled during a pulse. Heat is removed between discharges by radiation and pressure contacts to a water-cooled support structure. The pumping edge will be made of annealed pyrolytic graphite. Exhaust efficiency has been estimated, for a 1-d edge model, using a Monte-Carlo calculation of neutral gas transport. When the pump limiter is operated together with other wall components we expect an efficiency of ≅ 5% (2.5 x 10 21 part/s). As a main limiter the efficiency increases to about 10%. (author)

  7. Reactor limit control system

    International Nuclear Information System (INIS)

    Rubbel, F.E.

    1982-01-01

    The very extensive use of limitations in the operational field between protection system and closed-loop controls is an important feature of German understanding of operational safety. The design of limitations is based on very large activities in the computational field but mostly on the high level of the plant-wide own commissioning experience of a turnkey contractor. Limitations combine intelligence features of closed-loop controls with the high availability of protection systems. (orig.)

  8. Detector limitations, STAR

    Energy Technology Data Exchange (ETDEWEB)

    Underwood, D. G.

    1998-07-13

    Every detector has limitations in terms of solid angle, particular technologies chosen, cracks due to mechanical structure, etc. If all of the presently planned parts of STAR [Solenoidal Tracker At RHIC] were in place, these factors would not seriously limit our ability to exploit the spin physics possible in RHIC. What is of greater concern at the moment is the construction schedule for components such as the Electromagnetic Calorimeters, and the limited funding for various levels of triggers.

  9. Performance limitations at ISABELLE

    International Nuclear Information System (INIS)

    Keil, E.

    1975-01-01

    The transverse stability of coasting beams in the planned ISABELLE storage rings was studied. The beam--beam tune shift limitation at 0.005 can be avoided, and a computer simulation seems to show 0.005 is a pessimistic limit. For beams of reasonable smoothness on the edge, the actual limit should be somewhat higher. Some coupling effects due to the beam--beam interaction are also examined

  10. Limit loads in nozzles

    International Nuclear Information System (INIS)

    Zouain, N.

    1983-01-01

    The static method for the evaluation of the limit loads of a perfectly elasto-plastic structure is presented. Using the static theorem of Limit Analysis and the Finite Element Method, a lower bound for the colapso load can be obtained through a linear programming problem. This formulation if then applied to symmetrically loaded shells of revolution and some numerical results of limit loads in nozzles are also presented. (Author) [pt

  11. Limit analysis via creep

    International Nuclear Information System (INIS)

    Taroco, E.; Feijoo, R.A.

    1981-07-01

    In this paper it is presented a variational method for the limit analysis of an ideal plastic solid. This method has been denominated as Modified Secundary Creep and enables to find the collapse loads through a minimization of a functional and a limit process. Given an ideal plastic material it is shown how to determinate the associated secundary creep constitutive equation. Finally, as an application, it is found the limit load in an pressurized von Mises rigid plastic sphere. (Author) [pt

  12. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...... also enabled engineers to solve practical problems within reinforced concrete, steel structures and geotechnics....

  13. Advanced limiters for ISX

    International Nuclear Information System (INIS)

    Mioduszewski, P.K.; Edmonds, P.H.; Sheffield, J.

    1982-01-01

    Continuous removal of heat and particles becomes a vital necessity in future steady-state fusion devices. The pump limiter seems to be an attractive concept to combine these two tasks. On ISX, various schemes of pump limiters are being explored with the final goal to furnish the ISX--C device with a pump limiter to handle heat removal and particle control in steady state. The emphasis of the present paper is on pump limiters based on ballistic particle collection. If this concept turns out to be successful in supplying sufficient pumping efficiency, it may be possible to design pump limiters without a leading edge. Analytical calculations of the particle collection efficiency are given for various limiter configurations. Pumping efficiencies of approximately 4--10%, depending on the specific configuration, seem to be feasible and should be sufficient for steady-state operation. Initial experimental results on pump limiter studies in ISX--B confirm the calculated collection efficiencies. By measuring the ion saturation current to the limiter blade and the pressure buildup simultaneously, we found a correlation between the incident particle flux and the pressure rise that agrees well with a simple model

  14. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  15. Mitigating greenhouse: Limited time, limited options

    International Nuclear Information System (INIS)

    Moriarty, Patrick; Honnery, Damon

    2008-01-01

    Most human-caused climate change comes from fossil fuel combustion emissions. To avoid the risk of serious climate change, very recent research suggests that emission reductions will need to be both large and rapidly implemented. We argue that technical solutions-improving energy efficiency, use of renewable and nuclear energy, and carbon capture and sequestration-can only be of minor importance, mainly given the limited time available to take effective climate action. Only curbing energy use, perhaps through 'social efficiency' gains, particularly in the high-energy consumption countries, can provide the rapid emissions reductions needed. The social efficiency approach requires a basic rethinking in how we can satisfy our human needs with low environmental impacts. Large cuts in emissions could then occur rapidly, but only if resistance to such changes can be overcome. Particularly in transport, there are also serious potential conflicts between the technical and the social efficiency approaches, requiring a choice to be made

  16. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  17. Moving toroidal limiter

    International Nuclear Information System (INIS)

    Ikuta, Kazunari; Miyahara, Akira.

    1983-06-01

    The concept of the limiter-divertor proposed by Mirnov is extended to a toroidal limiter-divertor (which we call moving toroidal limiter) using the stream of ferromagnetic balls coated with a low Z materials such as plastics, graphite and ceramics. An important advantage of the use of the ferromagnetic materials would be possible soft landing of the balls on a catcher, provided that the temperature of the balls is below Curie point. Moreover, moving toroidal limiter would work as a protector of the first wall not only against the vertical movement of plasma ring but also against the violent inward motion driven by major disruption because the orbit of the ball in the case of moving toroidal limiter distributes over the small major radius side of the toroidal plasma. (author)

  18. Tokamak pump limiters

    International Nuclear Information System (INIS)

    Conn, R.W.

    1984-05-01

    Recent experiments with a scoop limiter without active internal pumping have been carried out in the PDX tokamak with up to 6MW of auxiliary neutral beam heating. Experiments have also been done with a rotating head pump limiter in the PLT tokamak in conjunction with RF plasma heating. Extensive experiments have been done in the ISX-B tokamak and first experiments have been completed with the ALT-I limiter in TEXTOR. The pump limiter modules in these latter two machines have internal getter pumping. Experiments in ISX-B are with ohmic and auxiliary neutral beam heating. The results in ISX-B and TEXTOR show that active density control and particle removal is achieved with pump limiters. In ISX-B, the boundary layer (or scape-off layer) plasma partially screens the core plasma from gas injection. In both ISX-B and TEXTOR, the pressure internal to the module scales linearly with plasma density but in ISX-B, with neutral beam injection, a nonlinear increase is observed at the highest densities studied. Plasma plugging is the suspected cause. Results from PDX suggest that a region may exist in which core plasma energy confinement improves using a pump limiter during neutral beam injection. Asymmetric radial profiles and an increased edge electron temperature are observed in discharges with improved confinement. The injection of small amounts of neon into ISX-B has more clearly shown an improved electron core energy confinement during neutral beam injection. While carried out with a regular limiter, this Z-mode of operation is ideal for use with pump limiters and should be a way to achieve energy confinement times similar to values for H-mode tokamak plasmas. The implication of all these results for the design of a reactor pump limiter is described

  19. Tokamak pump limiters

    International Nuclear Information System (INIS)

    Conn, R.W.; California Univ., Los Angeles

    1984-01-01

    Recent experiments with a scoop limiter without active internal pumping have been carried out in the PDX tokamak with up to 6 MW of auxiliary neutral beam heating. Experiments have also been performed with a rotating head pump limiter in the PLT tokamak in conjunction with RF plasma heating. Extensive experiments have been done in the ISX-B tokamak and first experiments have been completed with the ALT-I limiter in TEXTOR. The pump limiter modules in these latter two machines have internal getter pumping. Experiments in ISX-B are with ohmic and auxiliary neutral beam heating. The results in ISX-B and TEXTOR show that active density control and particle removal is achieved with pump limiters. In ISX-B, the boundary layer (or scrape-off layer) plasma partially screens the core plasma from gas injection. In both ISX-B and TEXTOR, the pressure internal to the module scales linearly with plasma density but in ISX-B, with neutral beam injection, a nonlinear increase is observed at the highest densities studied. Plasma plugging is the suspected cause. Results from PDX suggest that a regime may exist in which core plasma energy confinement improves using a pump limiter during neutral beam injection. Asymmetric radial profiles and an increased edge electron temperature are observed in discharges with improved confinement. The injection of small amounts of neon into ISX-B has more clearly shown an improved electron core energy confinement during neutral beam injection. While carried out with a regular limiter, this 'Z-mode' of operation is ideal for use with pump limiters and should be a way to achieve energy confinement times similar to values for H-mode tokamak plasmas. The implication of all these results for the design of a reactor pump limiter is described. (orig.)

  20. Novel limiter pump topologies

    International Nuclear Information System (INIS)

    Schultz, J.H.

    1981-01-01

    The use of limiter pumps as the principle plasma exhaust system of a magnetic confinement fusion device promises significant simplification, when compared to previously investigating divertor based systems. Further simplifications, such as the integration of the exhaust system with a radio frequency heating system and with the main reactor shield and structure are investigated below. The integrity of limiters in a reactor environment is threatened by many mechanisms, the most severe of which may be erosion by sputtering. Two novel topolgies are suggested which allow high erosion without limiter failure

  1. Novel limiter pump topologies

    International Nuclear Information System (INIS)

    Schultz, J.H.

    1981-01-01

    The use of limiter pumps as the principle plasma exhaust system of a magnetic confinement fusion device promises significant simplification, when compared to previously investigating divertor based systems. Further simplifications, such as the integration of the exhaust system with a radio frequency heating system and with the main reactor shield and structure are investigated below. The integrity of limiters in a reactor environment is threatened by many mechanisms, the most severe of which may be erosion by sputtering. Two novel topologies are suggested which allow high erosion without limiter failure

  2. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  3. Limited Income and Resources

    Data.gov (United States)

    U.S. Department of Health & Human Services — Information for those with limited income and resources (those who may qualify for or already have the Low Income Subsidy to lower their prescription drug coverage...

  4. SIS - Annual Catch Limit

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Annual Catch Limit (ACL) dataset within the Species Information System (SIS) contains information and data related to management reference points and catch data.

  5. Limited Denial of Participation

    Data.gov (United States)

    Department of Housing and Urban Development — A Limited Denial of Participation (LDP) is an action taken by a HUD Field Office or the Deputy Assistant Secretary for Single Family (DASSF) or Multifamily (DASMF)...

  6. Towards Improved Optical Limiters

    National Research Council Canada - National Science Library

    Huffman, Peter

    2002-01-01

    .... The first approach was to synthesize and study soluble thallium phthalocyanines. Thallium, due to its proximity to lead and indium on the periodic table, should exhibit favorable optical limiting properties...

  7. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  8. HOME Rent Limits

    Data.gov (United States)

    Department of Housing and Urban Development — In accordance with 24 CFR Part 92.252, HUD provides maximum HOME rent limits. The maximum HOME rents are the lesser of: The fair market rent for existing housing for...

  9. Limit lines for risk

    International Nuclear Information System (INIS)

    Cox, D.C.; Baybutt, P.

    1982-01-01

    Approaches to the regulation of risk from technological systems, such as nuclear power plants or chemical process plants, in which potential accidents may result in a broad range of adverse consequences must take into account several different aspects of risk. These include overall or average risk, accidents posing high relative risks, the rate at which accident probability decreases with increasing accident consequences, and the impact of high frequency, low consequence accidents. A hypothetical complementary cumulative distribution function (CCDF), with appropriately chosen parametric form, meets all these requirements. The Farmer limit line, by contrast, places limits on the risks due to individual accident sequences, and cannot adequately account for overall risk. This reduces its usefulness as a regulatory tool. In practice, the CCDF is used in the Canadian nuclear licensing process, while the Farmer limit line approach, supplemented by separate qualitative limits on overall risk, is employed in the United Kingdom

  10. Adjusting estimative prediction limits

    OpenAIRE

    Masao Ueki; Kaoru Fueda

    2007-01-01

    This note presents a direct adjustment of the estimative prediction limit to reduce the coverage error from a target value to third-order accuracy. The adjustment is asymptotically equivalent to those of Barndorff-Nielsen & Cox (1994, 1996) and Vidoni (1998). It has a simpler form with a plug-in estimator of the coverage probability of the estimative limit at the target value. Copyright 2007, Oxford University Press.

  11. Smoothness of limit functors

    Indian Academy of Sciences (India)

    Abstract. Let S be a scheme. Assume that we are given an action of the one dimen- sional split torus Gm,S on a smooth affine S-scheme X. We consider the limit (also called attractor) subfunctor Xλ consisting of points whose orbit under the given action. 'admits a limit at 0'. We show that Xλ is representable by a smooth ...

  12. Safety and design limits

    International Nuclear Information System (INIS)

    Shishkov, L. K.; Gorbaev, V. A.; Tsyganov, S. V.

    2007-01-01

    The paper touches upon the issues of NPP safety ensuring at the stage of fuel load design and operation by applying special limitations for a series of parameters, that is, design limits. Two following approaches are compared: the one used by west specialists for the PWR reactor and the Russian approach employed for the WWER reactor. The closeness of approaches is established, differences that are mainly peculiarities of terms are noted (Authors)

  13. Altruism and Reproductive Limitations

    Directory of Open Access Journals (Sweden)

    Carey J. Fitzgerald

    2009-04-01

    Full Text Available We examined how different types of reproductive limitations — functional (schizoid personality disorder and schizophrenia, physical (malnutrition, and sexual (bisexuality and homosexuality — influenced altruistic intentions toward hypothetical target individuals of differing degrees of relatedness (r = 0, .25, and .50. Participants were 312 undergraduate students who completed a questionnaire on altruism toward hypothetical friends, half-siblings, and siblings with these different types of reproductive limitations. Genetic relatedness and reproductive limitations did not influence altruistic decision-making when the cost of altruism was low but did as the cost of altruism increased, with participants being more likely to help a sibling over a half-sibling and a half-sibling over a friend. Participants also indicated they were more likely to help a healthy (control person over people with a reproductive limitation. Of the three types of reproductive limitations, functional limitations had the strongest effect on altruistic decision-making, indicating that people were less likely to help those who exhibit abnormal social behavior.

  14. Short Communication: Comparison of Maxim and Sedia Limiting Antigen Assay Performance for Measuring HIV Incidence.

    Science.gov (United States)

    Schlusser, Katherine E; Konikoff, Jacob; Kirkpatrick, Allison R; Morrison, Charles; Chipato, Tsungai; Chen, Pai-Lien; Munjoma, Marshall; Eshleman, Susan H; Laeyendecker, Oliver

    2017-06-01

    Accurate methods for cross-sectional incidence estimation are needed for HIV prevention research. The Limiting Antigen Avidity (LAg-Avidity) assay has been marketed by two vendors, Maxim Biomedical and Sedia BioSciences Corporation. Performance differences between the two versions of the assay are unknown. We tested a total 1,410 treatment-naive samples with both versions of the assay. The samples came from 176 seroconverters from the Zimbabwe Hormonal Contraception and HIV Study. The correlation between the two versions of the assay was 0.93 for the optical density (OD) and 0.86 for the normalized OD. As the difference was more pronounced for the normalized OD, the difference in assays can be attributed to the calibrators. The mean duration of recent infection (MDRI), the average time individuals infected 1,000 copies/ml. The MDRI was 137 days for Sedia and 157 days for Maxim, with a difference of 20 days (95% CI 11-30). The MDRIs decreased to 102 and 120 days with the inclusion of a viral load cutoff of >1,000 copies/ml. These results imply that use of the Sedia LAg-Avidity will result in estimates of incidence ∼13% lower than those using the Maxim LAg-Avidity.

  15. Force Limit System

    Science.gov (United States)

    Pawlik, Ralph; Krause, David; Bremenour, Frank

    2011-01-01

    The Force Limit System (FLS) was developed to protect test specimens from inadvertent overload. The load limit value is fully adjustable by the operator and works independently of the test system control as a mechanical (non-electrical) device. When a test specimen is loaded via an electromechanical or hydraulic test system, a chance of an overload condition exists. An overload applied to a specimen could result in irreparable damage to the specimen and/or fixturing. The FLS restricts the maximum load that an actuator can apply to a test specimen. When testing limited-run test articles or using very expensive fixtures, the use of such a device is highly recommended. Test setups typically use electronic peak protection, which can be the source of overload due to malfunctioning components or the inability to react quickly enough to load spikes. The FLS works independently of the electronic overload protection.

  16. Theory of limit cycles

    CERN Document Server

    Ye, Yan-Qian; Lo, Chi Y

    1986-01-01

    Over the past two decades the theory of limit cycles, especially for quadratic differential systems, has progressed dramatically in China as well as in other countries. This monograph, updating the 1964 first edition, includes these recent developments, as revised by eight of the author's colleagues in their own areas of expertise. The first part of the book deals with limit cycles of general plane stationary systems, including their existence, nonexistence, stability, and uniqueness. The second section discusses the global topological structure of limit cycles and phase-portraits of quadratic systems. Finally, the last section collects important results that could not be included under the subject matter of the previous two sections or that have appeared in the literature very recently. The book as a whole serves as a reference for college seniors, graduate students, and researchers in mathematics and physics.

  17. Using information and communication technology (ICT) to the maximum: learning and teaching biology with limited digital technologies

    Science.gov (United States)

    Van Rooy, Wilhelmina S.

    2012-04-01

    Background: The ubiquity, availability and exponential growth of digital information and communication technology (ICT) creates unique opportunities for learning and teaching in the senior secondary school biology curriculum. Digital technologies make it possible for emerging disciplinary knowledge and understanding of biological processes previously too small, large, slow or fast to be taught. Indeed, much of bioscience can now be effectively taught via digital technology, since its representational and symbolic forms are in digital formats. Purpose: This paper is part of a larger Australian study dealing with the technologies and modalities of learning biology in secondary schools. Sample: The classroom practices of three experienced biology teachers, working in a range of NSW secondary schools, are compared and contrasted to illustrate how the challenges of limited technologies are confronted to seamlessly integrate what is available into a number of molecular genetics lessons to enhance student learning. Design and method: The data are qualitative and the analysis is based on video classroom observations and semi-structured teacher interviews. Results: Findings indicate that if professional development opportunities are provided where the pedagogy of learning and teaching of both the relevant biology and its digital representations are available, then teachers see the immediate pedagogic benefit to student learning. In particular, teachers use ICT for challenging genetic concepts despite limited computer hardware and software availability. Conclusion: Experienced teachers incorporate ICT, however limited, in order to improve the quality of student learning.

  18. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2008-03-01

    Full Text Available mandate of contributing to improved quality of life and industrial competitiveness through research, development and innovation and in response to the National Research and Development Strategy and National Biotechnology Strategy....

  19. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2008-12-01

    Full Text Available the potential South African medicinal plants hold for the treatment of various diseases. Maharaj said they would focus on plant-based leads for anti-cancer drugs and treatment of Alzheimers disease while several local researchers would visit Korea from March...

  20. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2009-09-01

    Full Text Available Pharm™ gets the green light Deal concluded that will see tobacco plants become green factories to combat rabies A contract has been signed and sealed for an investment of R15m by South Africa's Innovation Fund for the final phases of development aimed... at the establishment of a start-up venture that will produce rabies virus neutralising antibodies through tobacco plants. This sees the formal birth of GreenPharm™, which is being incubated at the CSIR, from where the intellectual property originates...

  1. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2007-12-01

    Full Text Available towards ensuring that South Africa will develop its indigenous knowledge, apply new knowledge from life sciences in treating and/or preventing disease, manage the unique and fragile ecosystems and find more sustainable energy alternatives....

  2. Education: Bioscience Education through Bioparks.

    Science.gov (United States)

    Robinson, Michael H.

    1988-01-01

    Suggests creating a biological park to stress the interrelationships between plants and animals. States that the techniques of a zoo should be applied to paleontology, anatomy, anthropology. Gives advantages of this creative concept. (RT)

  3. Journal of Applied Biosciences: Submissions

    African Journals Online (AJOL)

    Authors should strictly adhere to these instructions to avoid delays in review process. An Author Agreement Form ... Your manuscript should be divided into the following sections: Title (brief and reflecting content of ... Abstract. Dividethe abstract further into sections with the following headings. Objectives: (in less than 50 ...

  4. Hadron collider luminosity limitations

    CERN Document Server

    Evans, Lyndon R

    1992-01-01

    The three colliders operated to date have taught us a great deal about the behaviour of both bunched and debunched beams in storage rings. The main luminosity limitations are now well enough understood that most of them can be stronglu attenuated or eliminated by approriate design precautions. Experience with the beam-beam interaction in both the SPS and the Tevatron allow us to predict the performance of the new generation of colliders with some degree of confidence. One of the main challenges that the accelerator physicist faces is the problem of the dynamic aperture limitations due to the lower field quality expected, imposed by economic and other constraints.

  5. SLC kicker magnet limitations

    International Nuclear Information System (INIS)

    Cassel, R.; Donaldson, A.; Mattison, T.; Bowden, G.; Weaver, J.; Bulos, F.; Fiander, D.

    1991-01-01

    The SLC Damping Ring kicker magnets requires a fast magnetic field rise time of 58 nsec, a peak field of 800 gauss, a pulse amplitude stability of 0.01%, and a reasonable operational lifetime. The original kicker magnets designed by SLAC and at Fermi were not able to fulfill the SLC kicker requirements. Extensive studies were conducted to determine the limitation in the magnets, response of the ferrite in kicker magnet, and the modifications needed to improve the kicker magnet performance. The paper details the SLAC and Fermi kicker magnets limitation of performance

  6. Activation analysis. Detection limits

    International Nuclear Information System (INIS)

    Revel, G.

    1999-01-01

    Numerical data and limits of detection related to the four irradiation modes, often used in activation analysis (reactor neutrons, 14 MeV neutrons, photon gamma and charged particles) are presented here. The technical presentation of the activation analysis is detailed in the paper P 2565 of Techniques de l'Ingenieur. (A.L.B.)

  7. Thermal background noise limitations

    Science.gov (United States)

    Gulkis, S.

    1982-01-01

    Modern detection systems are increasingly limited in sensitivity by the background thermal photons which enter the receiving system. Expressions for the fluctuations of detected thermal radiation are derived. Incoherent and heterodyne detection processes are considered. References to the subject of photon detection statistics are given.

  8. The Copyright Agency Limited.

    Science.gov (United States)

    Morgan, Caroline

    1993-01-01

    The evolution and functions of Australia's Copyright Agency Limited are described. The agency is a copyright collecting organization which collectively administers the rights of authors and publishers whose works are copied in education, and enters into blanket agreements with educational authorities outside the existing statutory license. Some…

  9. Occupational dose equivalent limits

    International Nuclear Information System (INIS)

    Goldfinch, E.P.

    1980-01-01

    This paper considers methods of limiting individual radiation risks by recognizing the variation of risk with age at exposure, taking into account both somatic and genetic risks and proposes a simple formula for controlling individual cumulative exposure and hence risk. (Author)

  10. The Limits of Accountability.

    Science.gov (United States)

    Bailey, Stephen K.

    This discussion, presented at the Regent's Trustees' Conference, February 1973, reviews the limits of accountability in higher education. Managerial efficiency is suggested to assist in eliminating educational and financial waste. This, however, is the secondary concept emphasized. The primary emphasis indicates the legitimacy of the claims that a…

  11. Limitations on blanket performance

    International Nuclear Information System (INIS)

    Malang, S.

    1999-01-01

    The limitations on the performance of breeding blankets in a fusion power plant are evaluated. The breeding blankets will be key components of a plant and their limitations with regard to power density, thermal efficiency and lifetime could determine to a large degree the attractiveness of a power plant. The performance of two rather well known blanket concepts under development in the frame of the European Blanket Programme is assessed and their limitations are compared with more advanced (and more speculative) concepts. An important issue is the question of which material (structure, breeder, multiplier, coatings) will limit the performance and what improvement would be possible with a 'better' structural material. This evaluation is based on the premise that the performance of the power plant will be limited by the blankets (including first wall) and not by other components, e.g. divertors, or the plasma itself. However, the justness of this premise remains to be seen. It is shown that the different blanket concepts cover a large range of allowable power densities and achievable thermal efficiencies, and it is concluded that there is a high incentive to go for better performance in spite of possibly higher blanket cost. However, such high performance blankets are usually based on materials and technologies not yet developed and there is a rather high risk that the development could fail. Therefore, it is explained that a part of the development effort should be devoted to concepts where the materials and technologies are more or less in hand in order to ensure that blankets for a DEMO reactor can be developed and tested in a given time frame. (orig.)

  12. Age Limit of Pediatrics.

    Science.gov (United States)

    Hardin, Amy Peykoff; Hackell, Jesse M

    2017-09-01

    Pediatrics is a multifaceted specialty that encompasses children's physical, psychosocial, developmental, and mental health. Pediatric care may begin periconceptionally and continues through gestation, infancy, childhood, adolescence, and young adulthood. Although adolescence and young adulthood are recognizable phases of life, an upper age limit is not easily demarcated and varies depending on the individual patient. The establishment of arbitrary age limits on pediatric care by health care providers should be discouraged. The decision to continue care with a pediatrician or pediatric medical or surgical subspecialist should be made solely by the patient (and family, when appropriate) and the physician and must take into account the physical and psychosocial needs of the patient and the abilities of the pediatric provider to meet these needs. Copyright © 2017 by the American Academy of Pediatrics.

  13. FTU pump limiter

    International Nuclear Information System (INIS)

    Alessandrini, C.; Ciotti, M.; Mattei, A. De; Maddaluno, G.; Mazzitelli, G.

    1989-01-01

    The control of the refuelling and recycling of the plasma is crucial in providing enhanced performances in tokamaks and steady-state operation in future reactors. In this paper, we report details of the design and analysis for the pump limiter to be incorporated into the FTU tokamak. The FTU, presently under commissioning, is a compact high field (B=8T), medium high density, circular cross section machine with small accesses. The dimensions of the equatorial port (width 8 cm) would reduce the length of the entrance throat to a few centimeters, which is unacceptable for efficient particle trapping. We have, therefore, designed a rotating blade of the pump limiter head that, in the working position, extends in the toroidal direction inside the vacuum chamber. (author) 8 refs., 4 figs

  14. Current limiter circuit system

    Science.gov (United States)

    Witcher, Joseph Brandon; Bredemann, Michael V.

    2017-09-05

    An apparatus comprising a steady state sensing circuit, a switching circuit, and a detection circuit. The steady state sensing circuit is connected to a first, a second and a third node. The first node is connected to a first device, the second node is connected to a second device, and the steady state sensing circuit causes a scaled current to flow at the third node. The scaled current is proportional to a voltage difference between the first and second node. The switching circuit limits an amount of current that flows between the first and second device. The detection circuit is connected to the third node and the switching circuit. The detection circuit monitors the scaled current at the third node and controls the switching circuit to limit the amount of the current that flows between the first and second device when the scaled current is greater than a desired level.

  15. Limits of Nuclear Stability

    CERN Document Server

    Nerlo-Pomorska, B; Kleban, M

    2003-01-01

    The modern version of the liquid-drop model (LSD) is compared with the macroscopic part of the binding energy evaluated within the Hartree-Fock- Bogoliubov procedure with the Gogny force and the relativistic mean field theory. The parameters of a liquid-drop like mass formula which approximate on the average the self-consistent results are compared with other models. The limits of nuclear stability predicted by these models are discussed.

  16. Are Limit Orders Rational?

    Czech Academy of Sciences Publication Activity Database

    Šmíd, Martin

    2007-01-01

    Roč. 14, č. 4 (2007), s. 32-38 ISSN 0572-3043 R&D Projects: GA ČR(CZ) GA402/06/1417; GA ČR GA402/04/1294; GA ČR GD402/03/H057 Institutional research plan: CEZ:AV0Z10750506 Keywords : market microstructure * limit order market * portfolio selection Subject RIV: AH - Economics

  17. INAA - application and limitation

    International Nuclear Information System (INIS)

    Heydorn, K.

    1990-01-01

    The uncertainties associated with performing Instrumental Neutron Activation Analysis (INAA) are discussed in relation to their category. The Comite International de Poids et Mesure (CIPM) distinguishes between uncertainties according to how their contribution to the overall uncertainty is evaluated. INAA is a potentially definitive method, if all sources of uncertainty can be accounted for. The limitation of the method is reached when uncertainties, which cannot be accounted for, assume significance, and the method cannot be brought in statistical control. (orig.)

  18. Density limits in Tokamaks

    International Nuclear Information System (INIS)

    Tendler, M.

    1984-06-01

    The energy loss from a tokamak plasma due to neutral hydrogen radiation and recycling is of great importance for the energy balance at the periphery. It is shown that the requirement for thermal equilibrium implies a constraint on the maximum attainable edge density. The relation to other density limits is discussed. The average plasma density is shown to be a strong function of the refuelling deposition profile. (author)

  19. Photovoltaic energy cost limit

    International Nuclear Information System (INIS)

    Coiante, D.

    1992-01-01

    Referring to a photovoltaic system for grid connected applications, a parametric expression of kWh cost is derived. The limit of kWh cost is carried out extrapolating the values of cost components to their lowest figure. The reliability of the forecast is checked by disaggregating kWh cost in direct and indirect costs and by discussing the possible cost reduction of each component

  20. Heat flux limiting sleeves

    Science.gov (United States)

    Harris, William G.

    1985-01-01

    A heat limiting tubular sleeve extending over only a portion of a tube having a generally uniform outside diameter, the sleeve being open on both ends, having one end thereof larger in diameter than the other end thereof and having a wall thickness which decreases in the same direction as the diameter of the sleeve decreases so that the heat transfer through the sleeve and tube is less adjacent the large diameter end of the sleeve than adjacent the other end thereof.

  1. Superconductive AC current limiter

    International Nuclear Information System (INIS)

    Bekhaled, M.

    1987-01-01

    This patent describes an AC current limiter for a power transport line including a power supply circuit and feeding a load circuit via an overload circuit-breaker member. The limiter comprises a transformer having a primary winding connected in series between the power supply circuit and the load circuit and at least one secondary winding of superconductor material contained in a cryogenic enclosure and short-circuited on itself. The leakage reactance of the transformer as seen from the primary winding is low, and the resistance of the at least one secondary winding when in the non-superconducting state and as seen from the primary is much greater than the nominal impedance of the transformer. The improvement whereby the at least one secondary winding of the transformer comprises an active winding in association with a set of auxiliary windings. The set of auxiliary windings is constituted by an even number of series-connected auxiliary windings wound in opposite directions, with the total number of turns in one direction being equal to the total number of turns in the opposite direction, and with the thermal capacity of the secondary winding as a whole being sufficiently high to limit the expansion thereof to a value which remains small during the time it takes the circuit-breaking member to operate

  2. Strategic arms limitation

    Science.gov (United States)

    Allen Greb, G.; Johnson, Gerald W.

    1983-10-01

    Following World War II, American scientists and politicians proposed in the Baruch plan a radical solution to the problem of nuclear weapons: to eliminate them forever under the auspices of an international nuclear development authority. The Soviets, who as yet did not possess the bomb, rejected this plan. Another approach suggested by Secretary of War Henry Stimson to negotiate directly with the Soviet Union was not accepted by the American leadership. These initial arms limitation failures both reflected and exacerbated the hostile political relationship of the superpowers in the 1950s and 1960s. Since 1969, the more modest focus of the Soviet-American arms control process has been on limiting the numbers and sizes of both defensive and offensive strategic systems. The format for this effort has been the Strategic Arms Limitatins Talks (Salt) and more recently the Strategic Arms Reduction Talks (START). Both sides came to these negotiations convinced that nuclear arsenals had grown so large that some for of mutual restraint was needed. Although the SALT/START process has been slow and ponderous, it has produced several concrete the agreements and collateral benefits. The 1972 ABM Treaty restricts the deployment of ballistic missile defense systems, the 1972 Interim Agreement places a quantitative freeze on each side's land based and sea based strategic launchers, and the as yet unratified 1979 SALT II Treaty sets numerical limits on all offensive strategic systems and sublimits on MIRVed systems. Collateral benefits include improved verification procedures, working definitions and counting rules, and permanent bureaucratic apparatus which enhance stability and increase the chances for achieving additional agreements.

  3. Beta limits for ETF

    International Nuclear Information System (INIS)

    Helton, F.J.; Miller, R.L.

    1982-01-01

    ETF (Engineering Test Facility) one-dimensional transport simulations indicate that a volume-average beta of 4% is required for ignition. It is therefore important that theoretical beta limits, determined by requiring equilibria to be stable to all ideal modes, exceed 4%. This paper documents an ideal MHD analysis wherein it is shown that, with appropriate plasma cross-sectional shape and current profile optimization, operation near 5% is possible. The critical beta value, however, depends on the functional form used for ff', which suggests that higher critical betas could be achieved by directly optimizing the safety factor profile. (author)

  4. Limitations of Boltzmann's principle

    International Nuclear Information System (INIS)

    Lavenda, B.H.

    1995-01-01

    The usual form of Boltzmann's principle assures that maximum entropy, or entropy reduction, occurs with maximum probability, implying a unimodal distribution. Boltzmann's principle cannot be applied to nonunimodal distributions, like the arcsine law, because the entropy may be concave only over a limited portion of the interval. The method of subordination shows that the arcsine distribution corresponds to a process with a single degree of freedom, thereby confirming the invalidation of Boltzmann's principle. The fractalization of time leads to a new distribution in which arcsine and Cauchy distributions can coexist simultaneously for nonintegral degrees of freedom between √2 and 2

  5. Fault current limiter

    Science.gov (United States)

    Darmann, Francis Anthony

    2013-10-08

    A fault current limiter (FCL) includes a series of high permeability posts for collectively define a core for the FCL. A DC coil, for the purposes of saturating a portion of the high permeability posts, surrounds the complete structure outside of an enclosure in the form of a vessel. The vessel contains a dielectric insulation medium. AC coils, for transporting AC current, are wound on insulating formers and electrically interconnected to each other in a manner such that the senses of the magnetic field produced by each AC coil in the corresponding high permeability core are opposing. There are insulation barriers between phases to improve dielectric withstand properties of the dielectric medium.

  6. Dose. Detriment. Limit assessment

    International Nuclear Information System (INIS)

    Breckow, J.

    2015-01-01

    One goal of radiation protection is the limitation of stochastic effects due to radiation exposure. The probability of occurrence of a radiation induced stochastic effect, however, is only one of several other parameters which determine the radiation detriment. Though the ICRP-concept of detriment is a quantitative definition, the kind of detriment weighting includes somewhat subjective elements. In this sense, the detriment-concept of ICRP represents already at the stage of effective dose a kind of assessment. Thus, by comparing radiation protection standards and concepts interconvertible or with those of environment or occupational protection one should be aware of the possibly different principles of detriment assessment.

  7. Marketing with limited budget

    OpenAIRE

    Smirnova, Daria

    2017-01-01

    The purpose of this research-based thesis was to get an idea how managers of two small resembling hotels of a specific region deal with marketing process with a limited budget. In addition, the aim of the thesis was to examine if hotel managers who were interviewed perceive marketing only in the way of ‘promotion’ rather than marketing research, marketing mix and marketing environment theories. It was also found out if hotel managers of those hotels consider marketing as a key to successful h...

  8. Limitation of Auditors' Liability

    DEFF Research Database (Denmark)

    Werlauff, Erik; Foged-Ladefoged, Lise Kolding

    2014-01-01

    The article examines the question of whether rules on the limitation of auditors’ liability within the perspective of EU law are needed, and if so, which rules can provide an appropriate balance between the potential injured party’s interests and those of the auditing sector, including with respect...... to the fact that the insurance premiums associated with an unlimited liability must of course make the auditor’s tasks more expensive. Relevant EU recommendations and a comparative glance at other EU countries’ proposed solutions to the problem are included....

  9. Limits to biofuels

    Directory of Open Access Journals (Sweden)

    Johansson S.

    2013-06-01

    Full Text Available Biofuel production is dependent upon agriculture and forestry systems, and the expectations of future biofuel potential are high. A study of the global food production and biofuel production from edible crops implies that biofuel produced from edible parts of crops lead to a global deficit of food. This is rather well known, which is why there is a strong urge to develop biofuel systems that make use of residues or products from forest to eliminate competition with food production. However, biofuel from agro-residues still depend upon the crop production system, and there are many parameters to deal with in order to investigate the sustainability of biofuel production. There is a theoretical limit to how much biofuel can be achieved globally from agro-residues and this amounts to approximately one third of todays’ use of fossil fuels in the transport sector. In reality this theoretical potential may be eliminated by the energy use in the biomass-conversion technologies and production systems, depending on what type of assessment method is used. By surveying existing studies on biofuel conversion the theoretical limit of biofuels from 2010 years’ agricultural production was found to be either non-existent due to energy consumption in the conversion process, or up to 2–6000TWh (biogas from residues and waste and ethanol from woody biomass in the more optimistic cases.

  10. Limits to biofuels

    Science.gov (United States)

    Johansson, S.

    2013-06-01

    Biofuel production is dependent upon agriculture and forestry systems, and the expectations of future biofuel potential are high. A study of the global food production and biofuel production from edible crops implies that biofuel produced from edible parts of crops lead to a global deficit of food. This is rather well known, which is why there is a strong urge to develop biofuel systems that make use of residues or products from forest to eliminate competition with food production. However, biofuel from agro-residues still depend upon the crop production system, and there are many parameters to deal with in order to investigate the sustainability of biofuel production. There is a theoretical limit to how much biofuel can be achieved globally from agro-residues and this amounts to approximately one third of todays' use of fossil fuels in the transport sector. In reality this theoretical potential may be eliminated by the energy use in the biomass-conversion technologies and production systems, depending on what type of assessment method is used. By surveying existing studies on biofuel conversion the theoretical limit of biofuels from 2010 years' agricultural production was found to be either non-existent due to energy consumption in the conversion process, or up to 2-6000TWh (biogas from residues and waste and ethanol from woody biomass) in the more optimistic cases.

  11. (Limiting the greenhouse effect)

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.

    1991-01-07

    Traveler attended the Dahlem Research Conference organized by the Freien Universitat, Berlin. The subject of the conference was Limiting the Greenhouse Effect: Options for Controlling Atmospheric CO{sub 2} Accumulation. Like all Dahlem workshops, this was a meeting of scientific experts, although the disciplines represented were broader than usual, ranging across anthropology, economics, international relations, forestry, engineering, and atmospheric chemistry. Participation by scientists from developing countries was limited. The conference was divided into four multidisciplinary working groups. Traveler acted as moderator for Group 3 which examined the question What knowledge is required to tackle the principal social and institutional barriers to reducing CO{sub 2} emissions'' The working rapporteur was Jesse Ausubel of Rockefeller University. Other working groups examined the economic costs, benefits, and technical feasibility of options to reduce emissions per unit of energy service; the options for reducing energy use per unit of GNP; and the significant of linkage between strategies to reduce CO{sub 2} emissions and other goals. Draft reports of the working groups are appended. Overall, the conference identified a number of important research needs in all four areas. It may prove particularly important in bringing the social and institutional research needs relevant to climate change closer to the forefront of the scientific and policy communities than hitherto.

  12. Limitations of inclusive fitness.

    Science.gov (United States)

    Allen, Benjamin; Nowak, Martin A; Wilson, Edward O

    2013-12-10

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed.

  13. The limitation and modification of flux-limited diffusion theory

    International Nuclear Information System (INIS)

    Liu Chengan; Huang Wenkai

    1986-01-01

    The limitation of various typical flux-limited diffusion theory and advantages of asymptotic diffusion theory with time absorption constant are analyzed and compared. The conclusions are as following: Though the flux-limited problem in neutron diffusion theory are theoretically solved by derived flux-limited diffusion equation, it's going too far to limit flux due to the inappropriate assumption in deriving flux-limited diffusion equation. The asymptotic diffusion theory with time absorption constant has eliminated the above-mentioned limitation, and it is more accurate than flux-limited diffusion theory in describing neutron transport problem

  14. Limits of Lubrication in

    DEFF Research Database (Denmark)

    Olsson, David Dam

    as delivered stainless steel surfaces implying microstructure changes in terms of larger ratio of closed lubricant pockets due to selective grain boundary etching. Strategic surfaces have also been created by macroscopic texturing using spherical indentations having a very small edge slope in order to promote...... by strategic surfaces in comparison to normal stainless steel surfaces implying a larger extent of bi-axial stretching. Numerical simulations have been applied in order to evaluate limits of lubrication in the simulative strip reduction based on predictions of critical parameters appearing in terms......-models corresponds well to experimental results in terms of lubricant film breakdown and subsequently pick-up development. Punching and blanking have been investigated regarding tribological conditions in case of using stainless steel workpiece materials. However, this has called for development of a new test method...

  15. Personal Freedom beyond Limits

    Directory of Open Access Journals (Sweden)

    Juan Fernando Sellés

    2013-07-01

    Full Text Available In this work we distinguish between freedom in the human manifestations (intelligence, will,actions and personal freedom in the personal intimacy. This second is beyond the freedom reached bythe classic and modern thought, since it takes root in the personnel act of being. Because of it, it is not possible to characterize this freedom like the classic description as ‘domain over the own acts’, becauseit is a description of ‘categorial’ order; neither like present day ‘autonomy’ or ‘independence’, becausethe existence of one person alone is impossible, since ‘person’ means relation, personal free openingto other persons, description of the ‘transcendental’ order and, therefore, to the margin of limits.

  16. [Does medicine limit enlightenment?].

    Science.gov (United States)

    Schipperges, H

    1977-01-01

    In the first, historical part the most important programs of "Medical Enlightenment", are pointed out, beginning with Leibniz, followed by the public health movement of the 18th century, up to the time of Immanuel Kant. Based on this historical background several concepts of a "Medical Culture" are analysed in detail, for instance the "Theorie einer Medizinal-Ordnung" by Johann Benjamin Ehrhard (1800), the "Medicinische Reform" by Rudolf Virchow (1848) and the programs of the "Gesellschaft Deutscher Naturforscher und Arzte" (about 1850-1890), the latter bearing both scientific and political character. Following the historical part, the question is raised whether "Enlightenment" is limited by medicine and whether medicine is able to provide a program for individual health education resulting in a more cultivated style of private life, and lastly how this might be realized.

  17. The Limits to Relevance

    Science.gov (United States)

    Averill, M.; Briggle, A.

    2006-12-01

    Science policy and knowledge production lately have taken a pragmatic turn. Funding agencies increasingly are requiring scientists to explain the relevance of their work to society. This stems in part from mounting critiques of the "linear model" of knowledge production in which scientists operating according to their own interests or disciplinary standards are presumed to automatically produce knowledge that is of relevance outside of their narrow communities. Many contend that funded scientific research should be linked more directly to societal goals, which implies a shift in the kind of research that will be funded. While both authors support the concept of useful science, we question the exact meaning of "relevance" and the wisdom of allowing it to control research agendas. We hope to contribute to the conversation by thinking more critically about the meaning and limits of the term "relevance" and the trade-offs implicit in a narrow utilitarian approach. The paper will consider which interests tend to be privileged by an emphasis on relevance and address issues such as whose goals ought to be pursued and why, and who gets to decide. We will consider how relevance, narrowly construed, may actually limit the ultimate utility of scientific research. The paper also will reflect on the worthiness of research goals themselves and their relationship to a broader view of what it means to be human and to live in society. Just as there is more to being human than the pragmatic demands of daily life, there is more at issue with knowledge production than finding the most efficient ways to satisfy consumer preferences or fix near-term policy problems. We will conclude by calling for a balanced approach to funding research that addresses society's most pressing needs but also supports innovative research with less immediately apparent application.

  18. Limit, breakthrough and prosperity

    International Nuclear Information System (INIS)

    Takahashi, Minoru

    1973-01-01

    It is pointed out that the flow toward serious crises is in progress with regard to energy and industrial problems. Technical and industrial preparation and countermeasure to the flow are proposed, and the existence of a certain new world attainable on the assumption that the countermeasure is successful is described. The relation between oil output and the increasing demand for energy is pointed out as a subject matter of the crisis. The contribution of oil energy to total energy, after the output turns to decreasing process, decreases by 177.87x10 6 tons (converted to coal at the rate 6848 kcal/kg) per year at maximum. Converted to the GNP of the world, this becomes (425 dollar/ton x 177.87 x 10 6 ton=75.6 x 10 9 dollar). This fluctuation width in a year must be compensated by the change of industrial structure and energy supplying means. The countermeasure and preparation are proposed from the viewpoints of the energy and the industrial structure in which nuclear power generation plays important role. The largest production on the earth limited by energy consumption and the temperature balance on the earth is investigated, and the perspective in the future is given. (Yamamoto, Y.)

  19. What value, detection limits

    International Nuclear Information System (INIS)

    Currie, L.A.

    1986-01-01

    Specific approaches and applications of LLD's to nuclear and ''nuclear-related'' measurements are presented in connection with work undertaken for the U.S. Nuclear Regulatory Commission and the International Atomic Energy Agency. In this work, special attention was given to assumptions and potential error sources, as well as to different types of analysis. For the former, the authors considered random and systematic error associated with the blank and the calibration and sample preparation processes, as well as issues relating to the nature of the random error distributions. Analysis types considered included continuous monitoring, ''simple counting'' involving scalar quantities, and spectrum fitting involving data vectors. The investigation of data matrices and multivariate analysis is also described. The most important conclusions derived from this study are: that there is a significant lack of communication and compatibility resulting from diverse terminology and conceptual bases - including no-basis ''ad hoc'' definitions; that the distinction between detection decisions and detection limits is frequently lost sight of; and that quite erroneous LOD estimates follow from inadequate consideration of the actual variability of the blank, and systematic error associated with the blank, the calibration-recovery factor, matrix effects, and ''black box'' data reduction models

  20. The limits of deterrence

    International Nuclear Information System (INIS)

    Tertrais, Bruno

    2009-01-01

    The objective of this contribution is to propose a better insight of the validity of the theory of deterrence, and of related doctrines in more complex and more various situations than in the past: emergence of powers like China and India, of new nuclear States like North Korea and Pakistan, of countries planning to acquire nuclear weapons like Iran, and possibility of a new wave of nuclear proliferation in Middle-East and north-eastern Asia. It also aims at providing arguments in the debates on the struggle against nuclear proliferation and on the future of deterrence. The author first presents and comments the principles of deterrence, and illustrates them by more or less recent historical situations (Iran during the war with Iraq, USA after Pearl Harbour, Arab-Israeli wars, Iraq, and so on). He notably outlines that the notion of deterrence is present in Islamic culture, and that Iran has well integrated it in its defence strategy. Examples of statements and behaviours of other Arab leaders are discussed. The author also briefly indicates how the deterrence strategy is present in the official doctrines of Russia, India, Pakistan, and North Korea. In a second part, based on various examples, the author analyses the practical limitations of deterrence by distinguishing the psychological dimension (bounded rationality, political leaders suffering from various psychological problems, importance of the ideological and spiritual dimension, values prevailing on interests, the case of Iran), and the strategic dimension (good understanding of the enemy, sensitivity of the threat of massive damages, existence of a single decision centre and of an efficient communication). The author finally proposes seven recommendations for better deterrence efficiency