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Sample records for bioscience limited anti-b

  1. Limits on the Decay-Rate Difference of Neutral-B Mesons and on CP, T, and CPT Violation in B0-antiB0 Oscillations

    CERN Document Server

    Aubert, Bernard; Abrams, G S; Adye, T; Ahmed, S; Alam, M S; Albert, J; Aleksan, Roy; Allison, J; Allmendinger, T; Altenburg, D; Andreotti, M; Angelini, C; Aston, D; Azzolini, V; Baak, M; Back, J J; Bailey, S; Baldini-Ferroli, R; Band, H R; Banerjee, Sw; Barate, R; Bard, D J; Barlow, N R; Barlow, R J; Bartoldus, R; Batignani, G; Bauer, J M; Beck, T W; Behera, P K; Bellini, F; Benayoun, M; Berger, N; Bernard, D; Berryhill, J W; Best, D; Bettarini, S; Bettoni, D; Bevan, A J; Bhimji, W; Bianchi, F; Blanc, F; Blaylock, G; Blinov, V E; Bloom, P; Bóna, M; Bondioli, M; Bonneaud, G R; Borean, C; Borgland, A W; Bosisio, L; Boutigny, D; Bowerman, D A; Boyarski, A M; Boyd, J T; Bozzi, C; Brandenburg, G; Brandt, T; Brau, B; Brau, J E; Breon, A B; Briand, H; Brochard, F; Brose, J; Brown, C L; Brown, C M; Brown, D N; Bruinsma, M; Brunet, S; Bucci, F; Buchmüller, O L; Bugg, W; Bukin, A D; Bulten, H J; Burchat, Patricia R; Button-Shafer, J; Buzzo, A; Côté, D; Cahn, R N; Calabrese, R; Calcaterra, A; Calderini, G; Campagnari, C; Capra, R; Carpinelli, M; Cartaro, C; Cavallo, N; Cavoto, G; Chao, M; Charles, E; Chauveau, J; Chen, A; Chen, E; Chen, J C; Chen, S; Cheng, C H; Chevalier, N; Christ, S; Cibinetto, G; Clark, P J; Cochran, J; Colberg, T; Colecchia, F; Coleman, J P; Contri, R; Convery, M R; Cormack, C M; Cossutti, F; Cottingham, W N; Couderc, F; Cowan, G; Cowan, R; Crawley, H B; Cremaldi, L M; Cristinziani, M; Crosetti, G; Çuhadar-Dönszelmann, T; Dahmes, B; Dallapiccola, C; Danielson, N; Dasu, S; Datta, M; Dauncey, P D; David, P; Davier, M; Davis, D; Day, C T; De Groot, N; De Nardo, Gallieno; Del Buono, L; Del Gamba, V; Della Ricca, G; Di Lodovico, F; Dickopp, M; Dittongo, S; Dong, D; Dorfan, J; Dorigo, A; Druzhinin, V P; Dubois-Felsmann, G P; Dujmic, D; Dunwoodie, W M; Dvoretskii, A; Eckmann, R; Edwards, A J; Egede, U; Eichenbaum, A M; Eigen, G; Eisner, A M; Elmer, P; Elsen, E E; Emery, S; Ernst, J A; Eschenburg, V; Eschrich, I; Fabozzi, F; Faccini, R; Fan, S; Farbin, A; Feltresi, E; Ferrarotto, F; Ferroni, F; Field, R C; Finocchiaro, G; Flack, R L; Flächer, H U; Flood, K T; Ford, K; Ford, W T; Forti, F; Fortin, D; Franek, B J; Frey, R; Fritsch, M; Fry, J R; Gabathuler, Erwin; Gabriel, T A; Gaidot, A; Gaillard, J M; Gaillard, J R; Galeazzi, F; Gallo, F; Gamba, D; Gamet, R; Gan, K K; Ganzhur, S F; Gary, J W; Gaspero, M; Gatto, C; Geddes, N I; Gill, M S; Giorgi, M A; Giraud, P F; Gladney, L; Glanzman, T; Godang, R; Goetzen, K; Golubev, V B; Gopal, G P; Gowdy, S J; Grancagnolo, S; Green, M G; Grenier, P; Gritsan, A V; Grosdidier, G; Groysman, Y; Guo, Q H; Hadavand, H K; Hadig, T; Haire, M; Halyo, V; Hamel de Monchenault, G; Hamon, O; Harrison, P F; Harrison, T J; Hart, P A; Hartfiel, C; Buchanan, B L; Harton, J L; Hast, C; Hauke, A; Hawkes, C M; Hearty, C; Held, T; Hertzbach, S S; Heusch, C A; Hicheur, A; Hill, E J; Hitlin, D G; Höcker, A; Hodgkinson, M C; Hollar, J J; Honscheid, K; Hrynóva, T; Hufnagel, D; Hulsbergen, W D; Igonkina, O; Innes, W R; Ivanchenko, V N; Izen, J M; Jackson, P D; Jacobsen, R G; Jawahery, A; Jayatilleke, S M; John, M J J; Johnson, J R; Judd, D; Kadel, R W; Kadyk, J; Kagan, H; Karyotakis, Yu; Kass, R; Kelly, M P; Kelsey, M H; Kerth, L T; Khan, A; Kim, H; Kim, P; Kirkby, D; Kitayama, I; Koch, H; Kocian, M L; Kofler, R; Kolomensky, Yu G; Koptchev, V B; Kovalskyi, D; Kowalewski, R V; Kozanecki, Witold; Kravchenko, E A; Krishnamurthy, M; Kroeger, R; Kukartsev, G; Kutter, P E; Lacker, H M; Lae, C K; Lafferty, G D; Lamsa, J; Lanceri, L; Lange, D J; Langenegger, R S; Dubitzky, U; Langer, M; Lankford, A J; Laplace, S; Latham, T E; Lavin, D; Le Clerc, C; Le Diberder, F R; Lees, J P; Legendre, M; Leith, D W G S; Lepeltier, V; Leruste, P; Levesque, J A; Levy, S L; Lewandowski, B; Li Gioi, L; Li, H; Libby, J; Lillard, V; Lista, L; Liu, R; Lo Secco, C P; Jessop, J M; Lo Vetere, M; Lockman, W S; London, G W; Long, O; Lou, X C; Lu, A; Lü, C; Luitz, S; Luppi, E; Lusiani, A; Lüth, V; Lutz, A M; Lynch, G; Lynch, H L; Lyon, A J; MacFarlane, D B; Macri, M; Mallik, G J; Grenier, U; Maly, E; Mancinelli, G; Mandelkern, M A; Mangeol, D J J; Marchiori, G; Margoni, M; Marker, C E; Marsiske, H; Martínez-Vidal, F; Mattison, T S; Mayer, B; Mazur, M A; Mazzoni, M A; McKenna, J A; McMahon, T R; Meadows, B T; Merchant, A M; Messner, R; Meyer, T I; Meyer, W T; Miftakov, V; Mihályi, A; Mir, L M; Mohanty, G B; Mohapatra, A K; Mommsen, R K; Monge, M R; Monorchio, D; Moore, T B; Morandin, M; Morgan, S E; Morganti, M; Morganti, S; Morii, M; Morton, G W; Muheim, F; Müller, D R; Müller-Pfefferkorn, R; Narsky, I; Nash, J A; Nauenberg, U; Neal, H; Negrini, M; Neri, N; Nicholson, H; Nogowski, R; O'Grady, C P; Ocariz, J; Oddone, P J; Ofte, I; Olaiya, E O; Olivas, A; Olsen, J; Onuchin, A P; Orimoto, T J; Otto, S; Ozcan, V E; Paar, H P; Paick, K; Palombo, A; Lazzaro, F; Pan, Y; Panetta, J; Panvini, R S; Paoloni, E; Paolucci, P; Parry, R J; Passaggio, S; Patel, P M; Patrignani, C; Patteri, P; Payne, D J; Pelizaeus, M; Perazzo, A; Perl, M; Peruzzi, F; Anulli, I M; Petersen, B A; Petersen, T C; Petrak, S; Petzold, A; Piatenko, T; Piccolo, D; Piccolo, M; Piemontese, L; Pierini, M; Pioppi, M; Biasini, M; Piredda, G; Pivk, M; Plaszczynski, S; Playfer, S; Pompili, A; Palano, A; Poropat, P; Porter, F C; Posocco, M; Potter, C T; Prell, S; Prepost, R; Pripstein, M; Pulliam, T; Purohit, M V; Qi, N D; Rahatlou, S; Rahimi, A M; Rama, M; Rankin, P; Ratcliff, B N; Raven, G; Re, P F; Manfredi, V R; Reidy, J; Ricciardi, S; Richman, J D; Ritchie, J L; Rizzo, G; Roat, C; Roberts, D A; Robertson, S H; Robutti, E; Roe, N A; Röthel, W; Ronan, Michael T; Roney, J M; Rong, G; Roodman, A; Roos, L; Rosenberg, E I; Rotondo, M; Ryd, A; Saeed, M A; Tehrani, F S; Saleem, M; Salnikov, A A; Salvatore, F; Samuel, A; Sanders, D A; Sandrelli, F; Santroni, A; Saremi, S; Sarti, A; Satpathy, A; Schalk, T; Schindler, R H; Schmitz, R E; Schott, G; Schrenk, S; Schubert, J; Schubert, Klaus R; Schumm, B A; Schune, M H; Schwiening, J; Schwierz, R; Schwitters, R F; Sciacca, C; Sciolla, G; Seiden, A; Sekula, S J; Serednyakov, S I; Sharma, V; Shelkov, V G; Shen, B C; Simani, M C; Simi, G; Simonetto, F; Sinev, N B; Skovpen, Yu I; Sloane, R J; Smith, A J S; Smith, J G; Snyder, A; Soffer, A; Soha, A; Sokoloff, M D; Solodov, E P; Spaan, B; Spanier, S M; Spradlin, P; Stängle, H; Steinke, M; Stelzer, J; Stoker, D P; Stroili, R; Strom, D; Stugu, B; Su, D; Sullivan, M K; Summers, D J; Sundermann, J E; T'Jampens, S; Tan, P; Tantot, L; Taras, P; Taylor, F; Taylor, G P; Telnov, A V; Teodorescu, P; Kyberd, L; Ter-Antonian, R; Therin, G; Thiebaux, C; Thiessen, D; Tiozzo, G; Tisserand, V; Toki, W H; Torrence, E; Tosi, S; Touramanis, C; Treadwell, E; Vaitsas, G; Vasileiadis, G; Vasseur, G; Vavra, J; Verderi, M; Verkerke, W; Vitale, L; Voci, C; Voena, C; Vuagnin, G; Wagner, G; Wagner, S R; Wagoner, D E; Waldi, R; Walsh, J; Wang, K; Wang, P; Wappler, F R; Watson, A T; Weaver, M; Weidemann, A W; Weinstein, A J R; Wenzel, W A; Wilden, L; Williams, D C; Williams, J C; Willocq, S; Wilson, F F; Wilson, M G; Wilson, R J; Winter, M A; Wisniewski, W J; Wittgen, M; Won, E; Wong, Q K; Wormser, G; Wright, D H; Wright, D M; Wu, J; Wu Sau Lan; Yamamoto, R K; Yang, S; Yarritu, A K; Ye, S; Yéche, C; Yi, J; Young, C C; Yu, Z; Yumiceva, F X; Yushkov, A N; Zallo, A; Zeng, Q L; Zghiche, A; Zhang, L; Zhao, H W; Zhu, Y S; Zito, M; De Sangro, R; Del Re, D; La Vaissière, C de; Von Wimmersperg-Töller, J H

    2004-01-01

    Using events in which one of two neutral-B mesons from the decay of an Y(4S) resonance is fully reconstructed, we set limits on the difference between the decay rates of the two neutral-B mass eigenstates and on CP, T, and CPT violation in B0-antiB0 mixing. The reconstructed decays, comprising both CP and flavor eigenstates, are obtained from 88 million Y(4S) --> Banti-B decays collected with the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We determine six independent parameters governing oscillations (Deltam, DeltaGamma/Gamma), CPT and CP violation (Re Z, Im Z), and CP and T violation (Im lambdaCP, |q/p|), where lambdaCP characterizes B0 and anti-B0 decays to states of charmonium plus K0S or K0L. The results are sgn(Re lambdaCP)xDeltaGamma/Gamma = -0.008 +/- 0.037(stat) +/- 0.018(syst) [-0.084,0.068], |q/p| = 1.029 +/- 0.013(stat) +/- 0.011(syst) [ 1.001,1.057], (Re lambdaCP)/|lambdaCP|xRe z = 0.014 +/- 0.035(stat) +/- 0.034(syst) [-0.072,0.101], Im z = 0.038 +/- 0.029(stat) +/- 0.025(s...

  2. Synchrotron radiation in biosciences

    Science.gov (United States)

    Marinkovic, Nebojsa S.; Gupta, Sayan; Zhan, Chenyang; Chance, Mark R.

    2005-12-01

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  3. Synchrotron radiation in biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Marinkovic, Nebojsa S. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)]. E-mail: marinkov@bnl.gov; Gupta, Sayan [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Zhan, Chenyang [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Chance, Mark R. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)

    2005-12-15

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  4. Ranolazine Roche Bioscience.

    Science.gov (United States)

    Jones, R

    1998-12-01

    Ranolazine is a metabolic modulator developed by Syntex (Roche) and is in phase III clinical trials as an anti-anginal agent and for the treatment of peripheral arterial disease, particularly intermittent claudication. It allows maintenance of energy output by muscle cells under hypoxic conditions. Ranolazine may be especially useful in angina patients in whom other therapies are ineffective. The licensee, CV Therapeutics (CVT), began a pivotal placebo-controlled, phase III clinical trial of ranolazine in October 1997 enrolling 150 angina patients [265551]. CVT plans to begin a second phase III trial in 350 to 400 angina patients receiving other anti-anginal medications during 1998 [279177]. Clinical studies suggest that ranolazine lowers the heart's demand for oxygen by increasing its ability to use carbohydrate, rather than fat, as a fuel. This is thought to be due to activation of pyruvate dehydrogenase and modulation of the activities of L-type calcium channels. This is achieved without reducing heart rate or blood pressure, or impairing pumping ability [253375,247228]. Ranolazine has been tested in more than 1300 US and European patients in phase I and phase II clinical trials, and is now being evaluated in a placebo-controlled, double-blind multicenter study to determine its effectiveness in treating stable angina. Phase II trials, in over 1200 patients with ischemic heart disease, were completed by Syntex. They demonstrated increased exercise times to onset of angina or electrocardiographic change associated with insufficient blood flow to the heart with three times daily dosing of ranolazine [224364]. Roche Bioscience claims that in the US and Western Europe approximately 1.4 million angina patients are not adequately treated with existing therapies and some 5 million patients suffer from intermittent claudication [166817]. In August 1998, CV Therapeutics signed an agreement with Catalytica Pharmaceuticals, which will manufacture specified quantities of

  5. Environmental Biosciences Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  6. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2009-09-01

    Full Text Available The CSIR’s research activities in the biosciences domain centre on the structure and function of the building blocks of life through molecular biology, cell biology, biochemistry, chemistry and genetics. The research focus is shaped by the CSIR’s...

  7. Microcontact Printing Techniques in Bioscience

    Institute of Scientific and Technical Information of China (English)

    FENG Xi-zeng; HOU Sun; CHAN Qi-lin; WANG Li-kai; QIN Ming; HAN Pei-dong

    2004-01-01

    The microcontact printing(μCP) technology available for patterning protein, DNA hybridization, immunoassay and cellular cocultures onto solid surface are reviewed. This review describes some of the techniques currently employed for creating two-dimensional biomolecular microarray, and the research results regarding their effectiveness. In addition, the applications of the impact of μCP technology in the field of biosciences are also presented.

  8. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2007-12-01

    Full Text Available development in the world," says Dr Chris Parkinson who leads the CSIR Biosciences discovery chemistry research group of which Van der Westhuyzen and Moleele are members. "The interests of Liotta's research group are well-aligned with our own. Simon, Chris..., Malefa and Pamisha will be exposed to pharmaceutical companies to get an idea about the hard-core end of the research pipeline," says Parkinson, who developed an acquaintance with Liotta in 2003. Together, they have been investigating means to train...

  9. Limit On The Neutral B(s) Meson Neutral Anti-b(s) Meson Oscillation Frequency From Proton-antiproton Collision Data At Center Of Mass Energy = 1.8 Tev

    CERN Document Server

    Niu, H

    2003-01-01

    This thesis presents a limit on the B0sB&d1;0 s oscillation frequency from pp¯ collision data at s = 1.8 TeV at CDF. The data sample used is the inclusive electron and muon trigger data of approximately 90 pb−1 collected during the 1993–1995 run. The B0s meson is reconstructed as B0s → νℓDs, where D s → &phis;π or K*0 K. The initial flavor of the B0s meson is determined from the decay products of the other b- hadron in the event, using opposite-side jet charge and soft lepton tagging methods. When combined with CDF previous measurements, a lower limit of Δms > 6.3 ps−1 is determined.

  10. Limit on the neutral strange B meson neutral strange anti-B meson oscillation frequency from proton-antiproton collision data at center of mass energy = 1.8 TeV

    Science.gov (United States)

    Niu, Hongquan

    This thesis presents a limit on the B0sB¯0 s oscillation frequency from pp¯ collision data at s = 1.8 TeV at CDF. The data sample used is the inclusive electron and muon trigger data of approximately 90 pb-1 collected during the 1993--1995 run. The B0s meson is reconstructed as B0s → nuℓDs, where D s → φpi or K*0 K. The initial flavor of the B0s meson is determined from the decay products of the other b-hadron in the event, using opposite-side jet charge and soft lepton tagging methods. When combined with CDF previous measurements, a lower limit of Deltams > 6.3 ps-1 is determined.

  11. Environmental Biosciences First Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-09-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  12. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2008-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  13. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  14. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  15. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2009-01-30

    Current research projects have focused Environmental Biosciences Program (EBP) talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene, low-dose ionizing radiation (gamma and neutron) and alpha radiation from plutonium. Trichloroethylene research has been conducted as a joint collaborative effort with the University of Georgia. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the United States Department of Energy (DOE). Laboratory work has been completed on several trichloroethylene risk assessment projects, and these projects have been brought to a close. Plans for restructuring the performance schedule of the remaining trichloroethylene projects have been submitted to the department. A comprehensive manuscript on the scientific basis of trichloroethylene risk assessment is in preparation. Work on the low-dose radiation risk assessment projects is also progressing at a slowed rate as a result of funding uncertainties. It has been necessary to restructure the proponency and performance schedule of these projects, with the project on Low-Dose Radiation: Epidemiology Risk Models transferred to DOE Office of Science proponency under a separate funding instrument. Research on this project will continue under the provisions of the DOE Office of Science funding instrument, with progress reported in accordance with the requirements of that funding instrument. Progress on that project will no longer be reported in quarterly reports for DE-FC09-02CH11109. Following a meeting at the Savannah River Site on May 8, 2008, a plan was submitted for development of an epidemiological cohort study and prospective medical surveillance system for the assessment of disease rates among workers at the Savannah River

  16. Journal of Applied Biosciences: Editorial Policies

    African Journals Online (AJOL)

    The Journal of Applied Biosciences provides a forum for scholars and ... e.g. genetically modified organisms and their contribution or detriment to nutrition and health. ... This journal provides immediate open access to its content on the principle ... Genetic Resources Unit, National Center for Agronomic Research Abidjan,

  17. Neuroscience meets salivary bioscience: An integrative perspective.

    Science.gov (United States)

    Segal, Sabrina K

    2016-04-01

    Advances in salivary bioscience enable unique opportunities to explore individual differences in biological mechanisms related to learning and memory, psychiatric disorders, and more recently neurodegenerative diseases, neurotrauma/stroke, pain, and sleep. Sampling oral fluid is not only minimally invasive, but specimens can be collected easily and quickly in clinical and field settings. Salivary analytes allow neuroscientists to index endocrine, autonomic, immune, metabolic, and inflammatory processes within close proximity of discrete behavioral, biological, and social events, which is particularly important to advancing our understanding of human neuroscience. This review provides an update on the advances in salivary bioscience for specialty fields within neuroscience, presents novel salivary analytes of interest to neuroscience and the status of their development, and outlines a procedural framework to facilitate integration of these concepts and methods into neuroscience. (PsycINFO Database Record

  18. Object-oriented programming for the biosciences.

    Science.gov (United States)

    Wiechert, W; Joksch, B; Wittig, R; Hartbrich, A; Höner, T; Möllney, M

    1995-10-01

    The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.

  19. Developing Research Capabilities in Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Donald D.

    2008-01-01

    Scientists founded the Life Sciences Research Foundation (LSRF) in 1983 as a non-profit pass through foundation that awards post doctoral fellowships in all areas of the life sciences. LSRF scientists review hundreds of applications each year from PhDs seeking support. For example this year, our 26th, we received 800 applications and our peer review committee will choose about 50 finalists who are eligible for these awards. We have no endowment so we solicit sponsors each year. The fellowships are sponsored by research oriented companies, foundations, philanthropists, the Howard Hughes Medical Institute, and other organizations who believe in the value of awarding fellowships to the best and the brightest young scientists. Our web site has a complete listing of all details about LSRF (http://www.lsrf.org/). In the late 1980s the Division of Bioscience in the Office of Basic Energy Science, a granting agency of the Department of Energy, joined this partnership. Bioscience's mandate was to support non-medical microbiology and plant sciences. LSRF received a series of 5 year grants from DOE to award fellowships to our top applicants in these fields of research. We began to support DOE-Energy Bioscience post doctoral fellows in 1989. From 1989 through 2004 when DOE funding ended our partnership awarded 41 DOE-Energy Bioscience Fellows of the Life Sciences Research Foundation. Each of these was a three year fellowship. DOE-Energy Biosciences was well matched with LSRF. Our extensive peer review screened applicants in all areas of the life sciences. Most LSRF sponsors are interested in supporting fellows who work on diseases. At the time that we began our partnership with DOE we had no sponsors willing to support plant biology and non medical microbiology. For 15 years DOE played a major role in the training of the very best young scientists in these important fields of research simply through its support of LSRF post doctoral fellows. Young scientists interested in

  20. Integrating anticipated nutrigenomics bioscience applications with ethical aspects.

    Science.gov (United States)

    Lévesque, Lise; Ozdemir, Vural; Gremmen, Bart; Godard, Béatrice

    2008-03-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surrounding nutrigenomics face the challenges of a rapidly evolving field which bring forward the additional dimension of crossdisciplinary integrative research between social and biomedical sciences. This article outlines the emerging nutrigenomics definitions and concepts and analyzes the existing ethics literature concerning personalized nutrition and presents "points to consider" over ethical issues regarding future nutrigenomics applications. The interest in nutrigenomics coincides with a shift in emphasis in medicine and biosciences toward prevention of future disease susceptibilities rather than treatment of already established disease. Hence, unique ethical issues emerge concerning the extent to which nutrigenomics can alter our relation to food, boundaries between health and disease, and the folklore of medical practice. Nutrigenomics can result in new social values, norms, and responsibilities for both individuals and societies. Nutrigenomics is not only another new application of "-omics" technologies in the context of gene-diet interactions. Nutrigenomics may fundamentally change the way we perceive human illness while shifting the focus and broadening the scope of health interventions from patients to healthy individuals. In resource- and time-limited healthcare settings, this creates unique ethical dilemmas and distributive justice issues. Ethical aspects of nutrigenomics applications should be addressed proactively, as this new science develops and increasingly coalesces with other applications of genomics in medicine and public health.

  1. Anti-B cell antibody therapies for inflammatory rheumatic diseases

    DEFF Research Database (Denmark)

    Faurschou, Mikkel; Jayne, David R W

    2014-01-01

    erythematosus, antineutrophil cytoplasmic antibody-associated vasculitis, polymyositis/dermatomyositis, and primary Sjögren's syndrome. For some anti-B cell agents, clinical benefits have been convincingly demonstrated, while other B cell-targeted therapies failed to improve outcomes when added to standard...

  2. Introducing bioinformatics, the biosciences' genomic revolution

    CERN Document Server

    Zanella, Paolo

    1999-01-01

    The general audience for these lectures is mainly physicists, computer scientists, engineers or the general public wanting to know more about what’s going on in the biosciences. What’s bioinformatics and why is all this fuss being made about it ? What’s this revolution triggered by the human genome project ? Are there any results yet ? What are the problems ? What new avenues of research have been opened up ? What about the technology ? These new developments will be compared with what happened at CERN earlier in its evolution, and it is hoped that the similiraties and contrasts will stimulate new curiosity and provoke new thoughts.

  3. Anti-B-B Mixing Constrains Topcolor-Assisted Technicolor

    Energy Technology Data Exchange (ETDEWEB)

    Burdman, Gustavo; Lane, Kenneth; Rador, Tonguc

    2000-12-06

    We argue that extended technicolor augmented with topcolor requires that all mixing between the third and the first two quark generations resides in the mixing matrix of left-handed down quarks. Then, the anti-B_d--B_d mixing that occurs in topcolor models constrains the coloron and Z' boson masses to be greater than about 5 TeV. This implies fine tuning of the topcolor couplings to better than 1percent.

  4. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  5. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  6. Environmental Biosciences Quarterly Report, September - December, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  7. Environmental Biosciences Program Report for Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-10-15

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  8. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  9. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.d.

    2003-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  10. Second Quarter Report Environmental Biosciences Program

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2002-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  11. The Bioscience Nuclear Microscopy Program at LLNL

    Energy Technology Data Exchange (ETDEWEB)

    Bench, G.; Freeman, S.; Roberts, M.; Sideras-Haddad, E.

    1996-12-31

    Since initiation in mid 1994, a bioscience nuclear microscopy program at Livermore has enabled collaboration with bio-scientists on a variety of projects requiring quantitative elemental microanalysis. For microprobe analysis a combination of PIXE and STIM are typically used; respectively generating element distribution maps with micron scale spatial resolution, and projected densities and histological information with sub-micron spatial resolution. Current studies demonstrate the applicability of nuclear microscopy (particularly when combined with other analysis techniques) in environmental tracing, toxicology, carcinogenesis, and structural biology. The program currently uses {approximately}10 percent of the available time on a 10 MV tandem accelerator that is also applied to a variety of Accelerator Mass Spectrometry and other microprobe programs. The completion of a dedicated nuclear microprobe system, using a 5 SDH NEC 1.7 MV tandem accelerator and employing several energy dispersive x-ray detectors to improve x-ray counting rates, promises increased accelerator access, greater sample throughput and continued expansion of the program.

  12. Environmental Biosciences Program Report for Year Three

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  13. Conference scene: Select Biosciences Epigenetics Europe 2010.

    Science.gov (United States)

    Razvi, Enal S

    2011-02-01

    The field of epigenetics is now on a geometric rise, driven in a large part by the realization that modifiers of chromatin are key regulators of biological processes in vivo. The three major classes of epigenetic effectors are DNA methylation, histone post-translational modifications (such as acetylation, methylation or phosphorylation) and small noncoding RNAs (most notably microRNAs). In this article, I report from Select Biosciences Epigenetics Europe 2010 industry conference held on 14-15 September 2010 at The Burlington Hotel, Dublin, Ireland. This industry conference was extremely well attended with a global pool of delegates representing the academic research community, biotechnology companies and pharmaceutical companies, as well as the technology/tool developers. This conference represented the current state of the epigenetics community with cancer/oncology as a key driver. In fact, it has been estimated that approximately 45% of epigenetic researchers today identify cancer/oncology as their main area of focus vis-à-vis their epigenetic research efforts.

  14. The (mathematical modelling process in biosciences

    Directory of Open Access Journals (Sweden)

    Nestor V. Torres

    2015-12-01

    Full Text Available In this communication we introduce a general framework and discussion on the role of models and the modelling process within the scientific activity in the biosciences realm. The objective is sum up the common procedure during the formalization and analysis of a biological problem under the foundations of Systems Biology, which approach the study of biological systems as a whole.We begin by presenting the definitions of (biological system and model. Particular attention is given to the meaning of mathematical model within the context of the biology. Then, we present the modelization and analysis process of biological systems. Three stages are described in detail: conceptualization of the biological system into a model, mathematical formalization of the previous conceptual model and optimization and system management derived from the analysis of the mathematical model.All along this presentation the main features and shortcomings of the process are developed together with a set of rules that could help in the modelling endeavour of any biological system. Special regard is given to the formative requirements and the interdisciplinary nature of this approach. We conclude with some general considerations on the challenges that the modelling are currently posing to the current biology.

  15. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  16. Resummation and matching of b-quark mass effects in b anti bH production

    Energy Technology Data Exchange (ETDEWEB)

    Bonvini, Marco [Oxford Univ. (United Kingdom). Rudolf Peierls Center for Theoretical Physics; Papanastasiou, Andrew S.; Tackmann, Frank J. [DESY Hamburg (Germany). Theory Group

    2015-11-15

    We use a systematic effective field theory setup to derive the b anti bH production cross section. Our result combines the merits of both fixed 4-flavor and 5-flavor schemes. It contains the full 4-flavor result, including the exact dependence on the b-quark mass, and improves it with a resummation of collinear logarithms of m{sub b}/m{sub H}. In the massless limit, it corresponds to a reorganized 5-flavor result. While we focus on b anti bH production, our method applies to generic heavy-quark initiated processes at hadron colliders. Our setup resembles the variable flavor number schemes known from heavy-flavor production in deep-inelastic scattering, but also differs in some key aspects. Most importantly, the effective b-quark PDF appears as part of the perturbative expansion of the final result where it effectively counts as an O(α{sub s}) object. The transition between the fixed-order (4-flavor) and resummation (5-flavor) regimes is governed by the low matching scale at which the b-quark is integrated out. Varying this scale provides a systematic way to assess the perturbative uncertainties associated with the resummation and matching procedure and reduces by going to higher orders. We discuss the practical implementation and present numerical results for the b anti bH production cross section at NLO+NLL. We also provide a comparison to the corresponding predictions in the fixed 4-flavor and 5-flavor results and the Santander matching prescription. Compared to the latter, we find a slightly reduced uncertainty and a larger central value, with its central value lying at the lower edge of our uncertainty band.

  17. anti B{sup 0}, B{sup -} and anti B{sub s}{sup 0} decays into J/ψ and K anti K or πη

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Wei-Hong [Guangxi Normal University, Department of Physics, Guilin (China); Xie, Ju-Jun [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Oset, E. [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain)

    2015-12-15

    We study the anti B{sub s}{sup 0} → J/ψK{sup +}K{sup -}, anti B{sup 0} → J/ψK{sup +}K{sup -}, B{sup -} → J/ψK{sup 0}K{sup -}, anti B{sup 0} → J/ψπ{sup 0}η and B{sup -} → J/ψπ{sup -}η decays and compare their mass distributions with those obtained for the anti B{sub s}{sup 0} → J/ψπ{sup +}π{sup -} and anti B{sup 0} → J/ψπ{sup +}π{sup -}. The approach followed consist in a factorization of the weak part and the hadronization part into a factor which is common to all the processes. Then what makes the reactions different are some trivial Cabibbo-Kobayashi-Maskawa matrix elements and the weight by which the different pairs of mesons appear in a primary step plus their final state interaction. These elements are part of the theory and thus, up to a global normalization factor, all the invariant mass distributions are predicted with no free parameters. Comparison is made with the limited experimental information available. Further comparison of these results with coming LHCb measurements will be very valuable to make progress in our understanding of the meson.meson interaction and the nature of the low lying scalar meson resonances, f{sub 0}(500), f{sub 0}(980) and a{sub 0}(980). (orig.)

  18. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  19. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation s need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyles (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  20. Environmental Biosciences Program Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  1. Environmental Biosciences Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk based decision-making. Questions, comments or requests for further information concerning the activities under this

  2. Bio-TDS: bioscience query tool discovery system.

    Science.gov (United States)

    Gnimpieba, Etienne Z; VanDiermen, Menno S; Gustafson, Shayla M; Conn, Bill; Lushbough, Carol M

    2017-01-04

    Bioinformatics and computational biology play a critical role in bioscience and biomedical research. As researchers design their experimental projects, one major challenge is to find the most relevant bioinformatics toolkits that will lead to new knowledge discovery from their data. The Bio-TDS (Bioscience Query Tool Discovery Systems, http://biotds.org/) has been developed to assist researchers in retrieving the most applicable analytic tools by allowing them to formulate their questions as free text. The Bio-TDS is a flexible retrieval system that affords users from multiple bioscience domains (e.g. genomic, proteomic, bio-imaging) the ability to query over 12 000 analytic tool descriptions integrated from well-established, community repositories. One of the primary components of the Bio-TDS is the ontology and natural language processing workflow for annotation, curation, query processing, and evaluation. The Bio-TDS's scientific impact was evaluated using sample questions posed by researchers retrieved from Biostars, a site focusing on BIOLOGICAL DATA ANALYSIS: The Bio-TDS was compared to five similar bioscience analytic tool retrieval systems with the Bio-TDS outperforming the others in terms of relevance and completeness. The Bio-TDS offers researchers the capacity to associate their bioscience question with the most relevant computational toolsets required for the data analysis in their knowledge discovery process.

  3. Impact of leptonic tau decays on the distribution of anti B → Dμ anti ν

    Energy Technology Data Exchange (ETDEWEB)

    Bordone, Marzia; Isidori, Gino; Dyk, Danny van [Physik-Institut, Universitaet Zuerich, Winterthurer Strasse 190, 8057 Zuerich (Switzerland)

    2016-07-01

    We present results for the decay rate of anti B → Dτ(→ μ anti νν) anti ν, which is a sizeable background to anti B → Dμ anti ν decays. In particular, we calculate analytically the differential decay rate with respect to all seven kinematic variables. We consider the impact of this decay on the distributions of anti B → Dμ anti ν in either the muon helicity angle or the muon energy in the anti B rest frame. Our numerical results are obtained from Monte Carlo pseudo events. Finally, we provide necessary information for cross checks of the experimental analyses.

  4. Teaching Critical Appraisal to Sport & Exercise Sciences and Biosciences Students

    Science.gov (United States)

    Phillips, Anna C.

    2009-01-01

    Seminars were implemented to develop undergraduates' critical appraisal skills and their effectiveness was evaluated. Participants were 140 undergraduate students consisting of 103 students from Sport and Exercise Sciences and 37 from Biosciences. Four seminars were employed to develop and reinforce critical thinking and provide an opportunity for…

  5. Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class

    Science.gov (United States)

    Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija

    2015-01-01

    University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…

  6. Integrating anticipated nutrigenomics bioscience applications with ethical aspects

    NARCIS (Netherlands)

    Levesque, L.; Ozdemir, V.; Gremmen, B.; Godard, B.

    2008-01-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surro

  7. Severe hemolysis caused by graft-derived anti-B production after lung transplantation

    DEFF Research Database (Denmark)

    Taaning, E; Morling, N; Mortensen, S A

    1996-01-01

    Anti-B antibody causing sever hemolytic anemia and renal failure was found in the serum of a blood group B patient who had received a bilateral lung transplant from a blood group O donor. Although the donor origin of the antibody was not confirmed, it is likely that the anti-B antibody was produced...

  8. Measurement of b anti b correlations at the CERN p anti p collider

    Energy Technology Data Exchange (ETDEWEB)

    Albajar, C.; Ankoviak, K.; Bartha, S.; Bezaguet, A.; Boehrer, A.; Bos, K.; Buchanan, C.; Buschbeck, B.; Castilla-Valdez, H.; Cennini, P.; Cittolin, S.; Clayton, E.; Cline, D.; Caughlan, J.A.; Dau, D.; Daum, C.; Della Negra, M.; Demoulin, M.; Denegri, D.; Dibon, H.; Dorenbosch, J.; Dowell, J.D.; Eggert, K.; Eisenhandler, E.; Ellis, N.; Evans, H.; Faissner, H.; Fensome, I.F.; Fortson, L.; Garvey, J.; Geiser, A. Givernaud, A.; Gonidec, A.; Gonzalez, B.; Gronberg, J.; Holthuizen, D.J.; Jank, W.; Jorat, G.; Kalmus, P.I.P.; Karimaeki, V.; Kenyon, I.; Kinnunen, R.; Krammer, M.; Lammel, S.; Landon, M.P.J.; Lemoigne, Y.; Levegruen, S.; Lipa, P.; Markou, C.; Markytan, M.; Maurin, G.; McMahon, S.; Merlo, J.P.; Meyer, T.; Moers, T.; Mohammadi, M.; Morsch, A.; Moulin, A.; Norton, A.; Otwinowski, S.; Pancheri, G.; Pietarinen, E.; Pimiae, M.; Placci, A.; Porte, J.P.; Priem, R.; Prosi, R.; Radermacher, E.; Rauschkolb, M.; Reithler, H.; Revol, J.P.; Robinson, D.; Rubbia, C.; Samyn, D.; Schinzel, D.; Sc; UA1 Collaboration

    1994-01-01

    We report on measurements of correlated b anti b production in p anti p at [radical]s=630 GeV, using dimuon data to tag both the b and anti b quarks. Starting from an inclusive dimuon sample we obtain improved cross-sections for single inclusive beauty production and confirm our earlier results on B[sup 0]- anti B[sup 0] mixing. From a study of b anti b correlations we derive explicit cross-sections for semi-differential b anti b production. We compare the measured cross-sections and correlations to OMIKRON ([alpha][sub s][sup 3]) QCD predictions and find good quantitative agreement. From the measured angular distributions we establish a sizeable contribution from higher order QCD processes with a significance of about seven standard deviations. A large nonperturbative contribution to these higher order corrections is excluded. (orig.)

  9. Bioscience methodologies in physical chemistry an engineering and molecular approach

    CERN Document Server

    D'Amore, Alberto

    2013-01-01

    The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

  10. Fluorescence lifetime imaging in biosciences: technologies and applications

    Institute of Scientific and Technical Information of China (English)

    Raluca NIESNER; Karl-Heinz GERICKE

    2008-01-01

    The biosciences require the development of methods that allow a non-invasive and rapid investigation of biological systems. In this aspect, high-end imaging tech-niques allow intravital microscopy in real-time, providing information on a molecular basis. Far-field fluorescence imaging techniques are some of the most adequate methods for such investigations. However, there are great differences between the common fluorescence imaging techniques, i.e., wide-field, confocal one-photon and two-photon microscopy, as far as their applicability in diverse bioscientific research areas is concerned. In the first part of this work, we briefly compare these techniques. Standard methods used in the biosciences, i.e., steady-state techniques based on the analy-sis of the total fluorescence signal originating from the sam-ple, can successfully be employed in the study of cell, tissue and organ morphology as well as in monitoring the macro-scopic tissue function. However, they are mostly inadequate for the quantitative investigation of the cellular function at the molecular level. The intrinsic disadvantages of steady-state techniques are countered by using time-resolved tech-niques. Among these fluorescence lifetime imaging (FLIM) is currently the most common. Different FLIM principles as well as applications of particular relevance for the biosci-ences, especially for fast intravital studies are discussed in this work.

  11. Full text and figure display improves bioscience literature search.

    Directory of Open Access Journals (Sweden)

    Anna Divoli

    Full Text Available When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  12. On the possibility to detect the Higgs decay H → b anti b in the associated Z + b anti b production at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Lipatov, A.V. [Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moscow (Russian Federation); Joint Institute for Nuclear Research, Dubna, Moscow Region (Russian Federation); Zotov, N.P. [Lomonosov Moscow State University, Skobeltsyn Institute of Nuclear Physics, Moscow (Russian Federation)

    2015-05-15

    We investigate the possibility to detect the scalar Higgs boson decay H → b anti b in the associated Z and b anti b production at the LHC using the k{sub T}-factorization QCD approach. Our consideration is based on the off-shell (i.e. depending on the transverse momenta of initial quarks and gluons) production amplitudes of q* anti q* → ZH → Zq' anti q', q* anti q* → Zq' anti q', and g*g* → Zq' anti q' partonic subprocesses supplemented with the Catani.Ciafoloni.Fiorani. Marchesini (CCFM) dynamics of parton densities in a proton. We argue that the H → b anti b signal could be observed at large transverse momenta near the Higgs boson peak despite the overwhelming QCD background, and we point out the important role of angular correlations between the produced Z boson and b-quarks. (orig.)

  13. Corrections to the bag factor in B- anti B-mixing

    Energy Technology Data Exchange (ETDEWEB)

    Grozin, Andrey G. [BINP, Novosibirsk (Russian Federation); Klein, Rebecca; Mannel, Thomas; Pivovarov, Alexei A. [Universitaet Siegen (Germany)

    2016-07-01

    B- anti B-Mixing is parameterized by the matrix elements of local operators O{sub i}. For the computation of these matrix elements a bag factor B{sub i} can be introduced left angle anti B vertical stroke O{sub i} vertical stroke B right angle =B{sub i} left angle anti B vertical stroke O{sub i} vertical stroke B right angle {sup fac}, which is unity in naive factorization. Any deviation from unity describes the accuracy of the naive factorization prescription. Corrections to B{sub i} emerge from QCD radiative corrections and from nonperturbative contributions at order 1/m{sub b}. We present the current status of these corrections to B{sub i}.

  14. Students Turned Off by Turnitin? Perception of Plagiarism and Collusion by Undergraduate Bioscience Students

    Science.gov (United States)

    Thompsett, Andrew; Ahluwalia, Jatinder

    2010-01-01

    Research on undergraduate bioscience students and the incidence of plagiarism is still in its infancy and a key problem arises in gauging the perception of undergraduate students on plagiarism and collusion in biosciences subjects because of the lack of empirical data. The aim of this study was to provide qualitative data on the perceptions of…

  15. Students Turned Off by Turnitin? Perception of Plagiarism and Collusion by Undergraduate Bioscience Students

    Science.gov (United States)

    Thompsett, Andrew; Ahluwalia, Jatinder

    2010-01-01

    Research on undergraduate bioscience students and the incidence of plagiarism is still in its infancy and a key problem arises in gauging the perception of undergraduate students on plagiarism and collusion in biosciences subjects because of the lack of empirical data. The aim of this study was to provide qualitative data on the perceptions of…

  16. 75 FR 64733 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal

    Science.gov (United States)

    2010-10-20

    ... HUMAN SERVICES Food and Drug Administration Arcadia Biosciences, Inc.; Filing of Food Additive Petition... proposing that the food additive regulations be amended to provide for the safe use of seed meal from a... is given that a food additive petition (FAP 2267) has been filed by Arcadia Biosciences, Inc.,...

  17. B/sup 0/-anti B/sup 0/ mixing: A theoretical evaluation after ARGUS

    Energy Technology Data Exchange (ETDEWEB)

    Bigi, I.

    1988-01-01

    After an introduction into the phenomenology of B/sup 0/ -anti B/sup 0/ mixing is given, a rather detailed is presented on the theoretical concepts that are involved. An attempt is made to elucidate the discrepancy between different theoretical claims. CP violtion is touched only very briefly.

  18. Applications of computational tools in biosciences and medical engineering

    CERN Document Server

    Altenbach, Holm

    2015-01-01

     This book presents the latest developments and applications of computational tools related to the biosciences and medical engineering. It also reports the findings of different multi-disciplinary research projects, for example, from the areas of scaffolds and synthetic bones, implants and medical devices, and medical materials. It is also shown that the application of computational tools often requires mathematical and experimental methods. Computational tools such as the finite element methods, computer-aided design and optimization as well as visualization techniques such as computed axial tomography open up completely new research fields that combine the fields of engineering and bio/medical. Nevertheless, there are still hurdles since both directions are based on quite different ways of education. Often even the “language” can vary from discipline to discipline.

  19. Communication and re-use of chemical information in bioscience

    Directory of Open Access Journals (Sweden)

    Mitchell John BO

    2005-07-01

    Full Text Available Abstract The current methods of publishing chemical information in bioscience articles are analysed. Using 3 papers as use-cases, it is shown that conventional methods using human procedures, including cut-and-paste are time-consuming and introduce errors. The meaning of chemical terms and the identity of compounds is often ambiguous. valuable experimental data such as spectra and computational results are almost always omitted. We describe an Open XML architecture at proof-of-concept which addresses these concerns. Compounds are identified through explicit connection tables or links to persistent Open resources such as PubChem. It is argued that if publishers adopt these tools and protocols, then the quality and quantity of chemical information available to bioscientists will increase and the authors, publishers and readers will find the process cost-effective.

  20. Communication and re-use of chemical information in bioscience

    Science.gov (United States)

    Murray-Rust, Peter; Mitchell, John BO; Rzepa, Henry S

    2005-01-01

    The current methods of publishing chemical information in bioscience articles are analysed. Using 3 papers as use-cases, it is shown that conventional methods using human procedures, including cut-and-paste are time-consuming and introduce errors. The meaning of chemical terms and the identity of compounds is often ambiguous. valuable experimental data such as spectra and computational results are almost always omitted. We describe an Open XML architecture at proof-of-concept which addresses these concerns. Compounds are identified through explicit connection tables or links to persistent Open resources such as PubChem. It is argued that if publishers adopt these tools and protocols, then the quality and quantity of chemical information available to bioscientists will increase and the authors, publishers and readers will find the process cost-effective. PMID:16026614

  1. Introduction to high-pressure bioscience and biotechnology.

    Science.gov (United States)

    Bartlett, Douglas H

    2010-02-01

    The manipulation of biological materials using elevated pressure is providing an ever-growing number of opportunities in both the applied and basic sciences. Manipulation of pressure is a useful parameter for enhancing food quality and shelf life; inactivating microbes, viruses, prions, and deleterious enzymes; affecting recombinant protein production; controlling DNA hybridization; and improving vaccine preparation. In biophysics and biochemistry, pressure is used as a tool to study intermediates in protein folding, enzyme kinetics, macromolecular interactions, amyloid fibrous protein aggregation, lipid structural changes, and to discern the role of solvation and void volumes in these processes. Biologists, including many microbiologists, examine the utility and basis of pressure inactivation of cells and cellular processes, and conversely seek to discover how deep-sea life has evolved a preference for high-pressure environments. This introduction and the papers that follow provide information on the nature and promise of the highly interdisciplinary field of high-pressure bioscience and biotechnology (HPBB).

  2. Measurement of the B^0-anti-B^0 oscillation frequency in hadronic B^0 Decays

    CERN Document Server

    Aubert, Bernard

    2001-01-01

    B^0-anti-B^0 flavor oscillations have been studied in 20.7 fb-1 of e^+e^- annihilation data collected in 1999 and 2000 with the BABAR detector at center-of-mass energies near the Upsilon(4S) resonance. The event sample consists of one B^0 meson fully reconstructed in a hadronic decay mode, while the flavor of the recoiling B^0 in the event is determined with a tagging algorithm that exploits the correlation between the flavor of the heavy quark and the charges of its decay products. By fitting the time development of the observed mixed and unmixed final states, the B^0-anti-B^0 oscillation frequency, Delta_md, is determined to be 0.519+/- 0.020+/- 0.016 ps^{-1}.

  3. Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

    DEFF Research Database (Denmark)

    Christensen, Andreas Lauge; Lohr, Christina; Christensen, Sune M.;

    2013-01-01

    , their fabrication via controlled self-assembly, and their characterization using fluorescence microscopy. We also highlight their applications in selected fields such as nanofluidics and single molecule bioscience. Despite their great potential for improved biocompatibility, extreme miniaturization and high...

  4. The 'bioscience problem' for nursing students: an integrative review of published evaluations of Year 1 bioscience, and proposed directions for curriculum development.

    Science.gov (United States)

    McVicar, Andrew; Andrew, Sharon; Kemble, Ross

    2015-03-01

    The difficulties that nursing students have in learning human biosciences have given cause for concern for over 20 years but the problem remains. To conduct an integrative review of published primary research into the 'bioscience problem', evaluate their outcomes, and provide a contemporary analysis of potential directions for curriculum planners. A systematic search of electronic databases CINAHL, Medline, British Nursing Index and Google Scholar was conducted for empirical research studies, published between 1990 and 2013, designed to either predict performance of students in bioscience assessments in Year 1 of their studies or identify in-course curriculum delivery issues. The search generated nineteen papers that met inclusion criteria. Twelve papers involved predictive factors for bioscience attainment and seven surveyed student views on curriculum issues. Four others that surveyed reflections of later-year students or qualified nurses on Year 1 outcomes were also retained for additional context. Prediction based on pre-admission academic achievement was not reliable. Student factors including age at entry, self-efficacy in science, and having appropriate study skills in particular appear to be confounding factors. In-course influences such as teaching strategy or lecturer skills are also inconsistent and likely to represent confounders operating at local, institutional level. The integrative review approach enabled analysis of incongruencies between studies that have been a barrier to curriculum development. Sound admissions criteria based on pre-university academic performance show promise in resolving the 'bioscience problem' but will likely be contingent on innovative support early in Year 1 for study skills and the fundamentals of human bioscience, plus attention to local quality assurance for curriculum delivery. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Inclusive b and b anti b production with quasi-multi-Regge kinematics at the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Kniehl, B.A. [Hamburg Univ. (Germany). II. Institut fuer Theoretische Physik; Saleev, V.A.; Shipilova, A.V. [Samara State University (Russian Federation)

    2010-03-15

    We consider b-jet hadroproduction in the quasi-multi-Regge-kinematics approach based on the hypothesis of gluon and quark Reggeization in t-channel exchanges at high energies. The preliminary data on inclusive b-jet and b anti b-dijet production taken by the CDF Collaboration at the Fermilab Tevatron are well described without adjusting parameters. We find the main contribution to inclusive b-jet production to be the scattering of a Reggeized gluon and a Reggeized b-quark to a b quark, which is described by the effective Reggeon-Reggeon-quark vertex. The main contribution to b anti b-pair production arises from the scattering of two Reggeized gluons to a b anti b pair, which is described by the effective Reggeon-Reggeon-quark-quark vertex. Our analysis is based on the Kimber-Martin-Ryskin prescription for unintegrated gluon and quark distribution functions using as input the Martin-Roberts-Stirling-Thorne collinear parton distribution functions of the proton. (orig.)

  6. Environmental Biosciences Program Third Quarter Report, Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  7. Foods: Where Innovation, Agriculture, Molecular Biosciences and Human Nutrition Meet

    Directory of Open Access Journals (Sweden)

    Charles Brennan

    2012-11-01

    Full Text Available There is one commodity the world over that unites mankind—food. In 2011 the United Nations claimed that the world’s population had reached the seven billion mark, a number which is set to increase dramatically in the decades to come. Food security, supply and sustainability are of paramount concern to the future economic and social progress of humanity. It is the responsibility of the food industry, together with food scientists and technologists, to shoulder the burden of ensuring an adequate supply of nutritious, safe and sensorially acceptable foods for a range of demanding consumers. In responding to this challenge, we need to understand the link between agriculture, engineering, food processing, molecular biosciences, human nutrition, commercialisation and innovation. Access to information concerning the composition and quality of foods has never been so easy for consumers and technologists alike. A plethora of research publications are made available each month to scientists and associated interested parties. The outcomes of these research manuscripts are often distilled and disseminated into messages available to everyone through bulletin boards, forums and the popular press. Newspapers and new agencies constantly report on the latest pharma-medical finding, or news regarding food safety and security concerns. We live in an age where information is so readily available to everyone that the task of finding credible and reputable data can be difficult at times. Providing sound evidenced based research is where a peer-reviewed journal can provide clarity. [...

  8. MUSC Environmental Biosciences Program First Quarter Report May - June, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr

    2002-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC02-98CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  9. Environmental Biosciences Program Quarterly Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  10. Limiter

    Science.gov (United States)

    Cohen, S.A.; Hosea, J.C.; Timberlake, J.R.

    1984-10-19

    A limiter with a specially contoured front face is provided. The front face of the limiter (the plasma-side face) is flat with a central indentation. In addition, the limiter shape is cylindrically symmetric so that the limiter can be rotated for greater heat distribution. This limiter shape accommodates the various power scrape-off distances lambda p, which depend on the parallel velocity, V/sub parallel/, of the impacting particles.

  11. Effect of exogenous circulating anti-bPL antibodies on bovine placental lactogen measurements in foetal samples

    Directory of Open Access Journals (Sweden)

    Taverne Marcel AM

    2010-02-01

    Full Text Available Abstract Background The involvement of placental lactogen (PL in the regulation of foetal growth has been investigated in different species by in vivo immunomodulation techniques. However, when circulating antibodies are present together with the hormone, the procedure for hormonal measurement becomes considerably complex. The aim of this study was the immunoneutralization of bovine placental lactogen (bPL concentrations in bovine foetal circulation by direct infusion of rabbit anti-bPL purified immunoglobulins (IgG via a foetal catheter (in vivo study. The ability of a RIA based on guinea pig anti-bPL antiserum, for the measurement of bPL concentrations in samples containing exogenous rabbit anti-bPL immunoglobulins, was also analyzed in in vitro and in vivo conditions. Methods Six bovine foetuses were chronic cannulated on the aorta via the medial tarsal artery. Infusion of rabbit anti-bPL IgG was performed during late gestation. Pooled rabbit anti-bPL antisera had a maximal neutralization capacity of 25 μg bPL/mL of immunoglobulin. Interference of rabbit anti-bPL immunoglobulin with radioimmunoassay measurement using guinea pig anti-bPL as primary antibody was first evaluated in vitro. Polyclonal anti-bPL antibodies raised in rabbit were added in foetal sera to produce 100 samples with known antibodies titers (dilutions ranging from 1:2,500 till 1:1,280,000. Result(s Assessment of the interference of rabbit anti-bPL antibody showed that bPL concentrations were significantly lower (P Conclusion(s The use of a bPL RIA using a guinea pig anti-bPL as primary antiserum allowed for the measurement of bPL concentrations in foetal plasma in presence of rabbit anti-bPL IgG into the foetal circulation. Long-term foetal catheterization allowed for the study of the influence of direct infusion of anti-bPL IgG on peripheral bPL concentrations in bovine foetuses.

  12. A study of b anti b production in e{sup +}e{sup -} collisions at {radical}(s)=130 -207 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Abdallah, J.; Antilogus, P.; Augustin, J.E.; Baubillier, M.; Berggren, M.; Da Silva, W.; Kapusta, F.; Savoy-Navarro, A. [Univ. Paris VI et VII, LPNHE, IN2P3-CNRS, Paris Cedex 05 (France); Abreu, P.; Andringa, S.; Anjos, N.; Castro, N.; Espirito Santo, M.C.; Goncalves, P.; Moreno, S.; Onofre, A.; Peralta, L.; Pimenta, M.; Tome, B.; Veloso, F. [LIP, IST, FCUL, Lisboa Codex (Portugal); Adam, W.; Buschbeck, B.; Leder, G.; Liko, D.; MacNaughton, J.; Mandl, F.; Mitaroff, W.; Strauss, J. [Oesterr. Akad. d. Wissensch., Institut fuer Hochenergiephysik, Vienna (Austria); Adzic, P.; Fanourakis, G.; Kokkinias, P.; Loukas, D.; Markou, A.; Mastroyiannopoulos, N.; Nassiakou, M.; Tzamarias, S.; Zupan, M. [N.C.S.R. Demokritos, Institute of Nuclear Physics, P.O. Box 60228, Athens (Greece); Albrecht, T.; Allmendinger, T.; Apel, W.D.; Boer, W. de; Feindt, M.; Haag, C.; Hauler, F.; Hennecke, M.; Jungermann, L.; Kerzel, U.; Moch, M.; Rehn, J.; Sander, C.; Stanitzki, M.; Weiser, C. [Universitaet Karlsruhe, Institut fuer Experimentelle Kernphysik, Postfach 6980, Karlsruhe (Germany); Alemany-Fernandez, R.; Ask, S.; Augustinus, A.; Baillon, P.; Battaglia, M.; Camporesi, T.; Carena, F.; Charpentier, P.; Chierici, R.; Chudoba, J.; Chung, S.U.; Collins, P.; Elsing, M.; Foeth, H.; Gavillet, P.; Holt, P.J.; Joram, C.; Kjaer, N.J.; Marin, J.C.; Mariotti, C.; Pape, L.; Parzefall, U.; Piotto, E.; Poireau, V.; Rebecchi, P.; Schwickerath, U.; Spassov, T.; Treille, D.; Van Eldik, J.; Van Vulpen, I.; Wicke, D. [CERN, Geneva 23 (Switzerland); Allport, P.P.; Booth, P.S.L.; Bowcock, T.J.V.; Houlden, M.A.; Jackson, J.N.; King, B.T.; Mc Nulty, R.; Palacios, J.P.; Tobin, M.; Washbrook, A.J. [University of Liverpool, Department of Physics, P.O. Box 147, Liverpool (United Kingdom); Amaldi, U.; Bonesini, M.; Calvi, M.; Matteuzzi, C.; Paganoni, M.; Pullia, A.; Tabarelli, T.; Tonazzo, A. [Univ. di Milano-Bicocca (Italy); INFN-MILANO, Dipartimento di Fisica, Milan (Italy)] [and others

    2009-03-15

    Measurements are presented of R{sub b}, the ratio of the b anti b cross-section to the q anti q cross-section in e{sup +}e{sup -} collisions, and the forward-backward asymmetry A{sub FB}{sup b} at twelve energy points in the range {radical}(s)=130-07 GeV. These results are found to be consistent with the Standard Model expectations. The measurements are used to set limits on new physics scenarios involving contact interactions. (orig.) 2.

  13. Annual report and summaries of FY 1993 activities: Division of Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The mission of the Energy Biosciences program is to generate fundamental information about plants and non-health related microorganisms that will constitute the base for new biotechnologies as well as supply information to improve usages of such organisms in their current form. The collective aims are totally consistent with the Department of Energy`s objectives of developing alternate energy sources, replacements for otherwise fossil energy derived products and providing critical fundamental information for the preservation and restoration of environmental conditions affected by energy related activities. The EB program takes full advantage of its organizational locale in the Office of Basic Energy Sciences to directly interact with such disciplines as Materials Sciences, Chemistry, Engineering and Geosciences to promote cross-disciplinary research and planning activities. One of the major specific objectives of the EB program is to probe the enormous capabilities of the specified organisms to carry out biochemical conversions. The limitation to realization of entirely new products and processes via biotechnology is the lack of basic understanding of natural processes. Such knowledge will then afford the advantage of developing procedures to the benefit of people and their society in providing new products along with providing new employment possibilities. This document consists of abstracts of projects supported in FY 1993.

  14. Automatic categorization of diverse experimental information in the bioscience literature

    Directory of Open Access Journals (Sweden)

    Fang Ruihua

    2012-01-01

    Full Text Available Abstract Background Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM. This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD. We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI. It is being used in

  15. Sensibility and specificity for pregnancy morbidity of anti-b2-glycoprotein I antibodies in antiphospholipid syndrome

    Directory of Open Access Journals (Sweden)

    S. Todesco

    2011-09-01

    Full Text Available Objective: This study aimed to evaluate the sensitivity and specificity of the anti-b2-glycoprotein I antibodies for pregnancy morbidity in the antiphosoplipid syndrome (APS. Methods: 335 women were recruited and on the basis of their clinical features were subdivided into 2 groups homogenous for number and age. The first (study group contained the women whose pregnancy complications satisfied the classification criteria for APS. The second (control group was made up of women with pregnancy complications not included in the classification criteria for APS. Anti-b2-GPI, anticardiolipin antibodies (aCL and lupus anticoagulants (LA were determined in all of these women. Results: The only antiphospholipid antibodies occurring with a significant frequency (p=0,00 in the women with pregnancy criteria for APS were the IgG anti-b2-GPI and the IgG aCL present respectively in 23,92% and in 27,60% of the women. Its association was found to be significant (p=0,000. The distribution of the different levels of positivity of the IgG and IgM anti-b2 GPI in the patients of the study and control groups was not significantly different. The highest sensitivity for pregnancy complications was that of the IgG aCL and of the IgG anti-b2 GPI whose difference was not statistically significant. The comparison of the specificity of the IgG and IgM anti-b2 GPI with that of the IgG and IGM aCL was not statistically significant. Conclusions: The importance of determining the IgG anti-b2 GPI as part of routine laboratory testing of women with pregnancy complications typical of APS was confirmed. Together with IgG aCL these antibodies have proved to be the most sensitive and specific markers of pregnancy complications in APS.

  16. The visual politics of animals in bioscience--earmice in the public sphere.

    Science.gov (United States)

    Brown, Nik

    2006-11-01

    This paper reports on a UK social science and anthropological study into the debates surrounding xenotransplantation (XT), involving interviews and focus group discussions across a number of different stakeholders (scientists, regulators and publics--including patient groups and other lay participants). In these discussions, one image in particular--that of 'earmouse'--surfaced repeatedly in consideration of XT and allied areas of bioscience. Whilst the image itself has little technically in common with XT or transgenic biotechnologies, it has nevertheless become ineradicably connected with them. This paper seeks to make sense of earmouse as an iconic reference through which people articulate their differing and highly contested views on bioscience.

  17. Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

    Science.gov (United States)

    Mayne, Lynne

    2012-01-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

  18. Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

    Science.gov (United States)

    Mayne, Lynne

    2012-01-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

  19. Anti-B-Cell Therapies in Autoimmune Neurological Diseases: Rationale and Efficacy Trials.

    Science.gov (United States)

    Alexopoulos, Harry; Biba, Angie; Dalakas, Marinos C

    2016-01-01

    B cells have an ever-increasing role in the etiopathology of a number of autoimmune neurological disorders, acting as antibody-producing cells and, most importantly, as sensors, coordinators, and regulators of the immune response. B cells, among other functions, regulate the T-cell activation process through their participation in antigen presentation and production of cytokines. The availability of monoclonal antibodies or fusion proteins against B-cell surface molecules or B-cell trophic factors bestows a rational approach for treating autoimmune neurological disorders, even when T cells are the main effector cells. This review summarizes basic aspects of B-cell biology, discusses the role(s) of B cells in neurological autoimmunity, and presents anti-B-cell drugs that are either currently on the market or are expected to be available in the near future for treating neurological autoimmune disorders.

  20. Technology Transfer in HEIs: A Case Study of Bioscience Commercialization at the University of Warwick

    Science.gov (United States)

    Gohir, Tas; Palmer, Grier

    2005-01-01

    The UK's bioscience research base is one of the country's genuine long-term economic assets. It is critically important for the UK not to repeat past mistakes, when financial exploitation of innovative and groundbreaking bioresearch went overseas. This study reviews commercialization from the Department of Biological Sciences at Warwick University…

  1. 77 FR 56175 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use)

    Science.gov (United States)

    2012-09-12

    ... petition proposing that the food additive regulations be amended to provide for the safe use in dry dog... CFR part 573) to provide for the safe use in dry dog food of oil from a variety of bioengineered... HUMAN SERVICES Food and Drug Administration 21 CFR Part 573 Arcadia Biosciences, Inc.; Filing of Food...

  2. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  3. Promoting active learning using audience response system in large bioscience classes.

    Science.gov (United States)

    Efstathiou, Nikolaos; Bailey, Cara

    2012-01-01

    This paper considers the challenges of bioscience teaching and learning in pre-registration nurse education. Effective learning requires active student participation which is problematic when teaching large groups of students. New technologies, such as the audience response system (ARS), have been introduced to increase student participation and support them in the understanding of complex bioscience concepts. Within one university department, an evaluation was undertaken to identify the perceptions of pre-registration nurse students on the use of ARS in the teaching and learning of bioscience. Our findings concur with others that ARS increases student participation and aids in identifying misconceptions and in correcting them. Students found ARS very useful and wanted ARS to be used in additional modules too. Although ARS did not seem to motivate students to study adequately before attending the relevant sessions, it increased discussion among students and awareness of their level of knowledge compared to their peers. Further research is required to identify the effectiveness of ARS in the teaching and learning of bioscience and its impact on the performance of the students in their final assessments.

  4. Reflective Practice: A Place in Enhancing Learning in the Undergraduate Bioscience Teaching Laboratory?

    Science.gov (United States)

    Parry, Damian; Walsh, Cathy; Larsen, Carl; Hogan, Joanne

    2012-01-01

    Bioscience employers demand graduates with better practical competence. It is our supposition that, although undesirable, student learning is assessment driven and this is leading students to simply go through the motions in the practical setting (whether field work or laboratory based). In this intervention a Critical Incident Report was…

  5. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  6. Development of an Electronic Role-Play Assessment Initiative in Bioscience for Nursing Students

    Science.gov (United States)

    Craft, Judy; Ainscough, Louise

    2015-01-01

    Devising authentic assessments for subjects with large enrolments is a challenge. This study describes an electronic role-play assessment for approximately 600 first-year nursing students to learn and apply pathophysiology (bioscience) concepts to nursing practice. Students used Microsoft Office PowerPoint[R] to prepare electronic role-plays both…

  7. "Novice Teachers" Views of an Introductory Workshop about Teaching in the Biosciences

    Science.gov (United States)

    Gartland, Kevan M. A.; Perkins, Joy; Shearer, Morven C.; Tierney, Anne M.; Wilson, Jackie J.

    2013-01-01

    Seven regional networking events, aimed at supporting and developing "early stage" novice university bioscience teachers were held across the UK. These workshops allowed 230 participants to reflect on teaching styles, learn about Higher Education Academy resources and discuss strategies to deal with a range of teaching situations.…

  8. Passive Immunization of Anti bZP3 (Zone Pellucida3 in Wistar Rat (Rattus novergicus and Mouse (Mus musculus

    Directory of Open Access Journals (Sweden)

    Y. Pantiwati

    2012-12-01

    Full Text Available This study was aimed at comparing the influence of anti bZP3’s passive immunization on anti-anti bZP3’s titer and pregnancy level on Wistar rats and mice. This study employed factorial design experiment with completely randomized design. The first factor was immunogenic type. The treated rats were immunized with 100 L anti bZP3 in 100 L Complete Freund’s Adjuvant (CFA, while the treated mice were injected with 50 L anti bZP3 in 50 L CFA. Control Wistar rats and mice were immunized with CFA and Incomplete Freund’s Adjuvant (IFA without anti bZP3. The second factor was animal type. The third factor was the length of serum incubation, i.e. 38, 49, 63, 86, 100, and 126 d. Dot blot on the treated Wistar rats and mice showed positive response proven by blue gradation; pre-immune mice as well as control Wistar rats and mice showed negative response proven by white gradation. The highest antibody titer in treated mouse serum was shown in 63 d incubation. The pregnancy on treated mice, control mice and Wistar rat occurred 100% until day 126; while the failure percentage on the treated mice was 4.5%. The pregnancy on treated mice occurred in 86 d incubation (1 rat, 100 d incubation (1 rat, and 126 d incubation (3 rats. Effective passive immunization on similar hospes occurred until day 63; while different hospes was ineffective. Antibodi anti-bZP3 was potential as a contraception through passive immunization on similar hospes.

  9. Predictions for the anti B{sup 0} → anti K{sup *0} X(YZ) and anti B{sub s}{sup 0} → φ X(YZ) with X(4160), Y(3940), Z(3930)

    Energy Technology Data Exchange (ETDEWEB)

    Liang, Wei-Hong [Guangxi Normal University, Department of Physics, Guilin (China); Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Molina, R.; Doering, M. [The George Washington University, Washington, DC (United States); Xie, Ju-Jun [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Institute of Modern Physics of CAS and Lanzhou University, Research Center for Hadron and CSR Physics, Lanzhou (China); Institute of Theoretical Physics, Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Beijing (China); Oset, E. [Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou (China); Centro Mixto Universidad de Valencia-CSIC Institutos de Investigacion de Paterna, Departamento de Fisica Teorica y IFIC, Valencia (Spain)

    2015-05-15

    We investigate the decay of anti B{sup 0} → anti K{sup *0}R and anti B{sub s}{sup 0} → φR with R being the X(4160), Y(3940), Z(3930) resonances. Under the assumption that these states are dynamically generated from the vector-vector interaction, as has been concluded from several theoretical studies, we use a reaction mechanism of quark production at the elementary level, followed by hadronization of one final q anti q pair into two vectors and posterior final state interaction of this pair of vector mesons to produce the resonances. With this procedure we are able to predict five ratios for these decays, which are closely linked to the dynamical nature of these states, and also predict the order of magnitude of the branching ratios which we find of the order of 10{sup -4}, well within the present measurable range. In order to further test the dynamical nature of these resonances we study the anti B{sub s}{sup 0} → φ D* anti D* and anti B{sub s}{sup 0} → φ D{sub s}{sup *} anti D{sub s}{sup *} decays close to the D* anti D* and D{sub s}{sup *} anti D{sub s}{sup *} thresholds and make predictions for the ratio of the mass distributions in these decays and the anti B{sub s}{sup 0} → φR decay widths. The measurement of these decays rates can help unravel the nature of these resonances. (orig.)

  10. Prevalence of anti-A and anti-B hemolysis among blood group O donors in Lagos.

    Science.gov (United States)

    Oyedeji, O A; Adeyemo, T A; Ogbenna, A A; Akanmu, A S

    2015-01-01

    Group O donor blood is more readily available and is frequently used as universal red cell donor in our environment. The presence of hemolysins in the donors may however lead to hemolysis in the recipients. Attempts have been made to study the prevalence of hemolysins in various populations with results from our environment showing wide variation (20-80%). To determine the prevalence and titer of anti-A and anti B hemolysins among blood donors at the Lagos University Teaching Hospital and compare results with that obtained elsewhere. Determine if the practice of transfusion of group O blood to nongroup O recipients is permissible in this environment. Test for hemolysis was done using the standard tube method. Samples positive for hemolysis were then scored and titrated with the titers read visually and photometrically at 540 nm. Three hundred and fifty blood group O donors with age range 18-58 years and median age of 28 ΁ 8.4 years were enrolled in the study. The overall prevalence of anti-A and/or anti-B hemolysins obtained was 30.3%. Prevalence of anti-A and anti-B hemolysins only was 15.4% and 5.1% respectively whereas both anti-A and anti-B hemolysins were present in 9.7% donor samples. Though anti-A hemolysins were more prevalent than anti-B hemolysins, anti-B hemolysins had higher mean visual (6:7) and spectrophotometric titers (81:101). A visual titer of 8 and above which is considered significant was seen in 18.6% of donor samples. Anti-A and anti-B hemolysins exist in significant frequencies and titers among blood group O donors in Lagos. It is recommended that the use of group O donor blood for recipients who are non-O be discouraged. Clinical studies to determine the frequency and severity of hemolysis in non-group O recipients of blood group O are required.

  11. Time Reversal Violation from the entangled B0-antiB0 system

    CERN Document Server

    Bernabeu, J; Villanueva-Perez, P

    2012-01-01

    We discuss the concepts and methodology to implement an experiment probing directly Time Reversal (T) non-invariance, without any experimental connection to CP violation, by the exchange of "in" and "out" states. The idea relies on the B0-antiB0 entanglement and decay time information available at B factories. The flavor or CP tag of the state of the still living neutral meson by the first decay of its orthogonal partner overcomes the problem of irreversibility for unstable systems, which prevents direct tests of T with incoherent particle states. T violation in the time evolution between the two decays means experimentally a difference between the intensities for the time-ordered (l^+ X, J/psi K_S) and (J/psi K_L, l^- X) decays, and three other independent asymmetries. The proposed strategy has been applied to simulated data samples of similar size and features to those currently available, from which we estimate the significance of the expected discovery to reach many standard deviations.

  12. Search for Higgs-boson production in association with top-quark pairs in H→b anti b decays at √(s)=8 and 13 TeV with the CMS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Garay Garcia, Jasone

    2016-08-15

    A search of the Higgs boson in association with a top-quark pair is presented, using pp collision data collected by the CMS detector at centre-of-mass energies of 8 and 13 TeV corresponding to integrated luminosities of 19.7 fb{sup -1} and 2.6 fb{sup -1}, respectively. Candidate t anti tH events are selected to enhance the dileptonic decay channel of the t anti t system and the decay of the Higgs boson into two b-quark jets (H→b anti b). The final state of the selected t anti tH(b anti b) processes is characterised by the presence of four b-jets, two originating from the t anti t system and two belonging to the Higgs-boson decay. The b-quark jet pair originating from the t anti t system is identified using multi-variate analysis techniques. In order to reduce the combinatorial background provided by the four b-jets in the final state, a generic method is developed to get an optimal separation between b and anti b jets. The remaining b-jets in the event are used to reconstruct the (m{sub b} {sub anti} {sub b}) invariant-mass distribution used to estimate the resonant signal above the non-resonant background and to determine the upper-limit on the t anti tH (b anti b) production. A combined fit to the data in two different categories results in an observed (expected) upper limit of μ<10.9(12.0) (for 8 TeV), and μ<13.4(14.4) (for 13 TeV) at the 95 % confidence level, where μ is the ratio of the observed t anti tH production cross section relative to the value expected for a Standard Model Higgs boson with m{sub H}=125 GeV.

  13. Search for Higgs boson pair production in the b anti bb anti b final state from pp collisions at √(s) = 8 TeV with the ATLAS detector

    Energy Technology Data Exchange (ETDEWEB)

    Aad, G. [CPPM, Aix-Marseille Univ. et CNRS/IN2P3, Marseille (France); Abbott, B. [Oklahoma Univ., Norman, OK (United States). Homer L. Dodge Dept. of Physics and Astronomy; Abdallah, J. [Academia Sinica, Taipei (China). Inst. of Physics; Collaboration: ATLAS Collaboration; and others

    2015-09-15

    A search for Higgs boson pair production pp → hh is performed with 19.5 fb{sup -1} of proton.proton collision data at √(s) = 8TeV, which were recorded by the ATLAS detector at the Large Hadron Collider in 2012. The decay products of each Higgs boson are reconstructed as a high-momentum b anti b system with either a pair of small-radius jets or a single large-radius jet, the latter exploiting jet substructure techniques and associated b-tagged track-jets. No evidence for resonant or non-resonant Higgs boson pair production is observed. The data are interpreted in the context of the Randall-Sundrum model with a warped extra dimension as well as the two-Higgs-doublet model. An upper limit on the cross-section for pp @→ G{sup *}{sub KK} @→ hh @→ b anti bb anti b of 3.2 (2.3) fb is set for a Kaluza-Klein graviton G{sup *}{sub KK} mass of 1.0(1.5)TeV, at the 95 % confidence level. The search for non-resonant Standard Model hh production sets an observed 95 % confidence level upper limit on the production cross-section σ(pp @→ hh @→ b anti bb anti b) of 202 fb, compared to a Standard Model prediction of σ(pp @→ hh @→ b anti bb anti b) = 3.6 @± 0.5fb. (orig.)

  14. Division of energy biosciences: Annual report and summaries of FY 1995 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

  15. The molecular biology revolution and the rise of bioscience megacentres in North America and Europe

    OpenAIRE

    Philip Cooke

    2004-01-01

    This paper focuses on 'triple helix' effects in biosciences. Scientific change can have profound socioeconomic effects. The molecular biology revolution tilted pharmaceuticals production away from its fine chemistry path dependence into microbiology and biotechnology. The key to any triple helix effects has thus shifted to universities and spinouts buttressed with burgeoning public funding, leaving 'big pharma' increasingly playing the role of licenser and marketer of bought-in therapeutic tr...

  16. anti B{sub d,s} → D{sup *}{sub d,s}V and anti B{sup *}{sub d,s} → D{sub d,s}V decays in QCD factorization and possible puzzles

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Qin [Henan Normal University, Institute of Particle and Nuclear Physics, Henan (China); Central China Normal University, Institute of Particle Physics, Wuhan (China); Chen, Ling-Xin; Zhang, Yun-Yun; Sun, Jun-Feng; Yang, Yue-Ling [Henan Normal University, Institute of Particle and Nuclear Physics, Henan (China)

    2016-10-15

    Motivated by the rapid development of heavy-flavor experiments, phenomenological studies of nonleptonic anti B{sub d,s} → D{sup *}{sub d,s}V and anti B{sup *}{sub d,s} → D{sub d,s}V (V = ρ, K*) decays are performed within the framework of QCD factorization. Relative to the previous work, the QCD corrections to the transverse amplitudes are evaluated at next-to-leading order. The theoretical predictions of the observables are updated. For the measured anti B{sub d,s} → D{sup *}{sub d,s}V decays, the tensions between theoretical results and experimental measurements, i.e. the ''R{sub ds}{sup V} puzzle'' and ''D*V (or R{sub V/l} {sub anti} {sub ν{sub l)}} puzzle'', are presented after detailed analyses. For the anti B{sup *}{sub d,s} → D{sub d,s}V decays, they have relatively large branching fractions of the order >or similar O(10{sup -9}) and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R{sub ds}{sup 'V} and R{sup '}{sub V/l} {sub anti} {sub ν{sub l.}} More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies. (orig.)

  17. Search for massive WH resonances decaying into the lνb anti b final state at √(s) = 8 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Khachatryan, V.; Sirunyan, A.M.; Tumasyan, A. [Yerevan Physics Institute, Yerevan (Armenia); and others

    2016-05-15

    A search for a massive resonance W'decaying into a W and a Higgs boson in the lνb anti b (l = e, μ) final state is presented. Results are based on data corresponding to an integrated luminosity of 19.7 fb{sup -1} of proton.proton collisions at √(s) = 8 TeV, collected using the CMS detector at the LHC. For a high-mass (>or similar 1 TeV) resonance, the two bottom quarks coming from the Higgs boson decay are reconstructed as a single jet, which can be tagged by placing requirements on its substructure and flavour. Exclusion limits at 95 % confidence level are set on the production cross section of a narrow resonance decaying into WH, as a function of its mass. In the context of a little Higgs model, a lower limit on the W' mass of 1.4 TeV is set. In a heavy vector triplet model that mimics the properties of composite Higgs models, a lower limit on the W' mass of 1.5 TeV is set. In the context of this model, the results are combined with related searches to obtain a lower limit on the W' mass of 1.8 TeV, the most restrictive to date for decays to a pair of standard model bosons. (orig.)

  18. Can active learning principles be applied to the bioscience assessments of nursing students? A review of the literature.

    Science.gov (United States)

    Bakon, Shannon; Craft, Judy; Christensen, Martin; Wirihana, Lisa

    2016-02-01

    To explore if active learning principles be applied to nursing bioscience assessments and will this influence student perception of confidence in applying theory to practice? A review of the literature utilising searches of various databases including CINAHL, PUBMED, Google Scholar and Mosby's Journal Index. The literature search identified research from twenty-six original articles, two electronic books, one published book and one conference proceedings paper. Bioscience has been identified as an area that nurses struggle to learn in tertiary institutions and then apply to clinical practice. A number of problems have been identified and explored that may contribute to this poor understanding and retention. University academics need to be knowledgeable of innovative teaching and assessing modalities that focus on enhancing student learning and address the integration issues associated with the theory practice gap. Increased bioscience education is associated with improved patient outcomes therefore by addressing this "bioscience problem" and improving the integration of bioscience in clinical practice there will subsequently be an improvement in health care outcomes. From the literature several themes were identified. First there are many problems with teaching nursing students bioscience education. These include class sizes, motivation, concentration, delivery mode, lecturer perspectives, student's previous knowledge, anxiety, and a lack of confidence. Among these influences the type of assessment employed by the educator has not been explored or identified as a contributor to student learning specifically in nursing bioscience instruction. Second that educating could be achieved more effectively if active learning principles were applied and the needs and expectations of the student were met. Lastly, assessment influences student retention and the student experience and as such assessment should be congruent with the subject content, align with the learning

  19. Design of an integrated team project as bachelor thesis in bioscience engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-11-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the design of this thesis. Because of the high number of students and the multidisciplinary nature of the graduates, all research divisions of the faculty are asked to participate. The yearly surveys and hearings were used for further optimisation. The actual design of this bachelor thesis is presented and discussed in this paper.

  20. Detection of serum anti-B/B’ UsnRNP antibodies in patients with connective tissue diseases by immunoblotting

    Directory of Open Access Journals (Sweden)

    L. Iaccarino

    2011-09-01

    Full Text Available Objective: To investigate the reliability of the immunoblot method in the detection of serum immunoreactivity towards the B/B’ polypeptides of U small nuclear ribonucleoproteins (UsnRNP and to assess the significance of these antibodies in connective tissue disease (CTD patients. Methods: We tested the sera of 348 patients with CTD (101 SLE, 51 systemic sclerosis, 53 primary Sjogren’s syndrome, 27 poly/dermatomyositis, 15 rheumatoid arthritis and 101 overlap CTD, of 31 matched healthy subjects and 13 patients with primary Epstein-Barr virus (EBV infection with high titre IgG anti-EBV antibodies. IgG anti-UsnRNP antibodies were determined by immunoblotting on nuclear extract from Raji cells (an EBV-immortalised human B lymphoid cell line and Jurkat cells (a human T lymphoid cell line. Anti-dsDNA antibodies were detected by indirect immunofluorescence on Crithidia luciliae and anti-ENA by counterimmunoelectrophoresis. Anti-dsDNA activity and avidity were measured in SLE sera by ELISA with Scatchard analysis. Results were statistically analysed by chi-square and Mann-Whitney tests. Results: A high frequency of anti-B/B’ antibodies was found in the sera of CTD patients, confined to SLE (54.4% and overlap CTD with SLE features (55,2%. Anti-B/B’ immune reactivity was closely associated with other anti-UsnRNP specificities, gel precipitating anti-nRNP and anti-P antibodies. Nine out of 15 (60% anti-B/B’ positive/anti-ENA negative lupus sera on Raji blots were confirmed to be positive also on Jurkat blots. The sera from patients with EBV infection provided, on Raji blots, completely different band patterns from those obtained with auto-immune sera. Conclusions. The Sm B/B’ proteins are the predominant or, at least, the most frequently targeted antigens of the UsnRNP auto-immune response in SLE and “lupus-like” overlap CTD. Moreover, anti-B/B’ is diagnostically specific for CTD with SLE features. Immunoblotting on human B lymphoid cells

  1. Ontologies and standards in bioscience research: for machine or for human

    Directory of Open Access Journals (Sweden)

    Huaiyu eMi

    2011-02-01

    Full Text Available Ontologies and standards are very important parts of today’s bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to manage and analyze the data. Most of these standards are initially designed for computers to access large amounts of data that are difficult for human biologists to handle, and it is important to keep in mind that ultimately biologists are going to produce and interpret the data. While ontologies and standards must follow strict semantic rules that may not be familiar to biologists, effort must be spent to lower the learning barrier by involving biologists in the process of development, and by providing software and tool support. A standard will not succeed without support from the wider bioscience research community. Thus, it is crucial that these standards be designed not only for machines to read, but also to be scientifically accurate and intuitive to human biologists.

  2. Division of Energy Biosciences annual report and summaries of FY 1996 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.

  3. Measurement of CP violation in B{sup 0}- anti B{sup 0} mixing using semileptonic decays at LHCb

    Energy Technology Data Exchange (ETDEWEB)

    Grillo, Lucia

    2015-07-22

    This thesis presents the measurement of the CP-violating asymmetry in B{sup 0}- anti B{sup 0} mixing using data corresponding to an integrated luminosity of 3.0 fb{sup -1} collected at the LHCb experiment in proton-proton collisions at the center-of-mass energies of 7 TeV and 8 TeV. This analysis uses untagged, semileptonic B{sup 0}→D{sup -}μ{sup +}ν{sup -} and B{sup 0}→D{sup *-}μ{sup +}ν{sup -} decays, where the D{sup -} decays into K{sup +}π{sup -}π{sup -}, and the D{sup *-} decays into anti D{sup 0}(→ K{sup +}π{sup -})π{sup -}. The neutrino in the semileptonic B decays is not reconstructed. A decay time dependent fit allows to disentangle the CP asymmetry from the possible B{sup 0}- anti B{sup 0} production asymmetry. Detection and reconstruction asymmetries are calibrated using promptly produced Cabibbo-favored D{sup +} decays, and inclusive secondary J/ψ decays. The CP-violating asymmetry is measured to be a{sup d}{sub sl}=(-0.02±0.19 (stat)±0.30(syst))%. This result is consistent with the Standard Model prediction, and it is the most precise measurement from a single experiment to date. This measurement is published in Physical Review Letters.

  4. Anti-B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis.

    Science.gov (United States)

    Coat, Juliette; Demoersman, Julien; Beuzit, Sébastien; Cornec, Divi; Devauchelle-Pensec, Valérie; Saraux, Alain; Pers, Jacques-Olivier

    2015-09-01

    Rheumatoid arthritis (RA) and periodontitis present many similar features. The benefits of anti-B lymphocyte therapy (rituximab) on reducing tissue resorption in RA prompted us to assess its potential efficacy on the periodontal status of patients with RA treated with rituximab. Periodontal status was assessed in 21 subjects with RA, divided into two groups: Group I consisted in 11 subjects assessed before their first infusion of rituximab and again 6 months later. Five of them were also assessed for up to 4 years after their first rituximab infusion. The 10 subjects in group II had received more than two courses of two rituximab infusions at the time of periodontal assessment. Pocket depth and attachment loss were significantly decreased 6 months after treatment with rituximab in group I. The periodontal status of the five subjects from group I followed for up to 48 months after rituximab treatment was improved irrespective of the clinical parameter observed. Patients from group II had a better periodontal status than patients from group I before treatment with rituximab. Anti-B lymphocyte therapy could be beneficial to improve periodontitis suggesting a major role of B cells in this disease. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  5. Search for the SM Higgs boson in the channel WH{yields}l{nu}b anti b with the ATLAS experiment at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Will, Jonas Zacharias

    2012-11-26

    One of the most important scientific challenges of ATLAS and CMS, multi-purpose detectors at CERN's Large Hadron Collider (LHC), is the discovery or exclusion of the longly sought standard model Higgs boson predicted almost fifty years ago. In summer 2012, both ATLAS and CMS discovered a new particle. Its mass is determined to be 126.0{+-}0.4(stat){+-} 0.4(sys) GeV (ATLAS) and 125.3{+-}0.4(stat){+-}0.5 (sys) GeV. Its further properties are so far consistent with the predicted properties of a standard model Higgs boson within large uncertainties. Besides the Higgs search in the sensitive bosonic channels, H{yields}{gamma}{gamma}, H{yields}ZZ, and H{yields}WW, the fermionic channels H{yields}{tau}{tau} and H{yields}b anti b contributed to the exclusion of a standard model Higgs boson below the observed excess and are essential for measuring the couplings of the new particle to fermions. In the analysis presented here, the associated Higgs production WH in the Higgs decay channel H{yields}b anti b is studied on the collision data corresponding to an integrated luminosity of 4.7 fb{sup -1} recorded by ATLAS in 2011 at a proton-proton centre-of-mass energy of 7 TeV. A cut-based analysis selects events with the signature of interest, consisting of one lepton (electron, muon), missing transverse energy, and two b jets. Techniques for a data-driven estimate of the multijet background are developed, validated and applied. The different contributions from heavy and light flavour jets to the W+jets background are estimated by a data-driven method. Furthermore, the large background components from top and W+jets are normalized using collision data. The invariant mass of the two selected jets m{sub b} {sub anti} {sub b} is used for the determination of exclusion limits on the Higgs signal strength {sigma}/{sigma}{sub WH} in the mass window 110 GeV{<=}m{sub H}{<=}130 GeV. For a hypothesized Higgs mass of m{sub H}=110 GeV, the Higgs signal strength is excluded for values

  6. Freqüência de hemolisinas anti-A e anti-B em doadores de sangue de Itapeva e Ourinhos Anti-A and anti-B hemolysin frequencies in blood donors from Itapeva and Ourinhos

    OpenAIRE

    Fernandes, Vanessa C; Borgatto,Adriano F.; Silvio Barberato Filho; Maria Inês de Toledo; Lopes, Luciane C

    2008-01-01

    Uma transfusão de sangue com o tipo ABO incorreto pode resultar na morte do paciente, com reação hemolítica intravascular, seguida de alterações imunológicas e bioquímicas. Considerando a pequena quantidade de estudos sobre as hemolisinas anti-A e anti-B e a importância desses anticorpos na prática transfusional, o objetivo deste trabalho foi verificar a frequência dessas hemolisinas e a associação a fatores como etnia e gênero em doadores de sangue dos bancos de sangue dos municípios de Itap...

  7. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences

    Science.gov (United States)

    King, Nicola C.; Aves, Stephen J.

    2012-01-01

    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  8. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences

    Science.gov (United States)

    King, Nicola C.; Aves, Stephen J.

    2012-01-01

    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  9. Production of Doctorates in the Biosciences, 1975-1980: An Experimental Forecast. Higher Education Panel Reports, No. 34.

    Science.gov (United States)

    Atelsek, Frank J.; Gomberg, Irene L.

    A survey was undertaken in 1976 to obtain short-term estimates of doctorate production directly from the heads of the science departments involved. These biosciences departments were surveyed in the 235 member institutions of the Higher Education Panel that grant doctorates: anatomy, biochemistry, biology, biometry/biostatistics/biomathematics,…

  10. Freqüência de hemolisinas anti-A e anti-B em doadores de sangue do Hemocentro de Botucatu Anti-A and anti-B hemolysin frequencies in blood donors from the Hemotherapy Center of Unesp, Botucatu

    Directory of Open Access Journals (Sweden)

    Sheley Gambero

    2004-03-01

    Full Text Available O Sistema ABO foi descoberto em 1900 e permanece até hoje como sendo o sistema mais importante dentro da prática transfusional. A transfusão ABO incorreta pode resultar na morte do paciente, com uma reação hemolítica intravascular, seguida de alterações imunológicas e bioquímicas. Os anticorpos ABO estão presentes nos soros dos indivíduos, dirigidos contra os antígenos A e/ou B ausentes nas hemácias. Embora as transfusões com pequenas quantias de plasmas incompatíveis sejam geralmente consideradas uma prática segura, alguns casos de reações hemolíticas por plasma incompatível são encontrados na literatura. Tendo em vista a pequena quantidade de estudos sobre as hemolisinas anti-A e anti-B e a importância desses anticorpos na prática transfusional, objetivamos neste trabalho verificar a freqüência dessas hemolisinas em doadores de sangue do Hemocentro da Unesp de Botucatu. Foram analisadas 600 amostras de soros de doadores do grupo "O" para presença ou ausência das hemolisinas anti-A e anti-B. Desses doadores, 77 (12,8% foram classificados como perigosos por apresentarem em seu soro altos títulos de hemolisinas e 523 (87,2% como não perigosos por apresentarem baixos títulos. No grupo dos doadores perigosos, 45 (58,4% foram reativos para hemolisina anti-A, 11 (14,2% reativos para hemolisina anti-B e 21 (27,2% reativos para ambas. O título de aglutininas superior a 1/100 já considera o doador "O" como perigoso. Assim, o teste realizado em nossa rotina é suficiente para detecção de altos títulos fazendo com que os pacientes dos outros grupos sangüíneos não corram o risco de reação transfusional se necessitarem de transfusão sangüínea não-isogrupo.The ABO system was discovered in 1990 and remains until today the most important system in transfusional practice. The wrong ABO transfusion can result in death of the patient after a hemolytic reaction followed by immunological and biochemical changes. ABO

  11. Googling your genes: personal genomics and the discourse of citizen bioscience in the network age

    Directory of Open Access Journals (Sweden)

    Marina Levina

    2010-03-01

    Full Text Available In this essay, I argue that the rise of personal genomics is technologically, economically, and most importantly, discursively tied to the rise of network subjectivity, an imperative of which is an understanding of self as always already a subject in the network. I illustrate how personal genomics takes full advantage of social media technology and network subjectivity to advertise a new way of doing research that emphasizes collaboration between researchers and its members. Sharing one’s genetic information is considered to be an act of citizenship, precisely because it is good for the network. Here members are encouraged to think of themselves as dividuals, or nodes, in the network and their actions acquire value based on that imperative. Therefore, citizen bioscience is intricately tied, both in discourse and practices, to the growth of the network in the age of new media.

  12. Assessment of Collaboration and Interoperability in an Information Management System to Support Bioscience Research

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L.

    2009-01-01

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C4I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the “must have” attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation. PMID:20351900

  13. On the outside looking in: redefining the role of analytical chemistry in the biosciences.

    Science.gov (United States)

    Hare, Dominic J; New, Elizabeth J

    2016-07-12

    Biomedical research has moved on from the study of the structure of organs, cells and organelles. Today, the key questions that must be addressed to understand the body in health and disease are related to fundamental biochemistry: the distribution and speciation of chemicals, the regulation of chemical reactions, and the control of chemical environments. To see advances in this field, it is essential for analytical chemists to actively engage in this process, from beginning to end. In this Feature Article, we review the progress that has been made towards gaining an understanding of the chemistry of the body, while commenting on the intrinsic disconnect between new innovations in the field of analytical chemistry and practical application within the biosciences. We identify the challenges that prevent chemists from making a greater impact in this field, and highlight key steps for moving forward.

  14. Assessment of collaboration and interoperability in an information management system to support bioscience research.

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L

    2009-11-14

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C(4)I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the "must have" attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation.

  15. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience.

    Science.gov (United States)

    Aicardi, Christine

    2016-02-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a 'cross-worlds influencer' who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise 'un-disciplined' new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against 'vitalism': anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of 'doing science' and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: 'follow the cross-worlds influencers' who worked to build and organise these semi-institutional gatherings and institutional structures.

  16. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience

    Science.gov (United States)

    Aicardi, Christine

    2016-01-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a ‘cross-worlds influencer’ who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise ‘un-disciplined’ new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against ‘vitalism’: anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of ‘doing science’ and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: ‘follow the cross-worlds influencers’ who worked to build and organise these semi-institutional gatherings and institutional structures. PMID:26383132

  17. Measurement of the time dependence of $B^{0}-anti-B^{0}$ oscillations using inclusive dilepton events

    CERN Document Server

    Aubert, Bernard; Boutigny, D; De Bonis, I; Favier, Jean; Gaillard, Jean-Marc; Galeazzi, F; Jérémie, A; Karyotakis, Yu; Lees, J P; Robbe, P; Tisserand, V; Zachariadou, K; Palano, A; Chen, G P; Chen Jia Chao; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Reinertsen, P L; Stugu, B; Abbott, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Clark, A R; Fan, Q; Gill, M S; Gowdy, S J; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J A; Kerth, L T; Kluth, S; Kral, J F; Leclerc, C; Levi, M E; Liu, T; Lynch, G; Meyer, A B; Momayezi, M; Oddone, P J; Perazzo, A; Pripstein, M; Roe, N A; Romosan, A; Ronan, Michael T; Shelkov, V G; Strother, P; Telnov, A V; Wenzel, W A; Champion, T J; Hawkes, C M; Kirk, A; O'Neale, S W; Watson, A T; Watson, N K; Koch, H; Krug, J; Kunze, M; Lewandowski, B; Peters, K; Schmücker, H; Steinke, M; Andress, J C; Chevalier, N; Clark, P J; Cottingham, N; De Groot, N; Dyce, N; Foster, B; Mass, A; McFall, J D; Wallom, D; Wilson, F F; Abe, K; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Camanzi, B; McKemey, A K; Tinslay, J; Blinov, V E; Bukin, A D; Bukin, D A; Buzykaev, A R; Dubrovin, M S; Golubev, V B; Ivanchenko, V N; Korol, A A; Kravchenko, E A; Onuchin, A P; Salnikov, A A; Serednyakov, S I; Skovpen, Yu I; Yushkov, A N; Lankford, A J; Mandelkern, M A; Stoker, D P; Ahsan, A; Arisaka, K; Buchanan, C D; Chun, S; Branson, J G; Faccini, R; MacFarlane, D B; Rahatlou, S; Raven, G; Sharma, V; Campagnari, C; Dahmes, B; Hart, P A; Kuznetsova, N P; Levy, S L; Long, O; Lu, A; Richman, J D; Verkerke, W; Witherell, M; Yellin, S; Beringer, J; Dorfan, D E; Eisner, A M; Frey, A; Grillo, A A; Grothe, M; Heusch, C A; Johnson, R P; Kröger, W; Lockman, W S; Pulliam, T; Sadrozinski, H F W; Schalk, T L; Schmitz, R E; Schumm, B A; Seiden, A; Turri, M; Williams, D C; Chen, E; Dubois-Felsmann, G P; Dvoredsky, A P; Hitlin, D G; Kolomensky, Yu G; Metzler, S; Oyang, J Y T; Porter, F C; Ryd, A; Samuel, A; Weaver, M; Yang, S; Zhu, R Y; Aleksan, Roy; De Domenico, G; de Lesquen, A; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Langer, M; London, G W; Mayer, B; Serfass, B; Vasseur, G; Yéche, C; Zito, M; Devmal, S C; Geld, T L; Jayatilleke, S M; Mancinelli, G; Meadows, B T; Sokoloff, M D; Blouw, J; Harton, J L; Krishnamurthy, M; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Fahey, S; Ford, W T; Gaede, F; Johnson, D R; Michael, A K; Nauenberg, U; Olivas, A; Park, H; Rankin, P; Roy, J D; Sen, S; Smith, J G; Wagner, D L; Brandt, T; Brose, J; Dahlinger, G; Dickopp, M; Dubitzky, R S; Kocian, M L; Müller-Pfefferkorn, R; Schubert, Klaus R; Schwierz, R; Spaan, B; Wilden, L; Behr, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Ferrag, S; Roussot, E; Thiebaux, C; Vasileiadis, G; Verderi, M; Anjomshoaa, A; Bernet, R; Di Lodovico, F; Muheim, F; Playfer, S; Swain, J E; Bozzi, C; Dittongo, S; Folegani, M; Piemontese, L; Treadwell, E A; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Zallo, A; Bagnasco, S; Buzzo, A; Contri, R; Crosetti, G; Fabbricatore, P; Farinon, S; Lo Vetere, M; Macri, M; Monge, M R; Musenich, R; Parodi, R; Passaggio, S; Pastore, F; Patrignani, C; Pia, M G; Priano, C; Robutti, E; Santroni, A; Cochran, J; Crawley, H B; Fischer, P A; Lamsa, J; Meyer, W T; Rosenberg, E I; Bartoldus, R; Dignan, T; Hamilton, R; Mallik, U; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Carpinelli, M; Forti, F; Giorgi, M A; Lusiani, A; Morganti, M; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Simi, G; Triggiani, G; Benkebil, M; Grosdidier, G; Hast, C; Höcker, A; Le Peltier, V; Lutz, A M; Plaszczynski, S; Schune, M H; Trincaz-Duvoid, S; Valassi, Andrea; Wormser, G; Bionta, R M; Brigljevic, V; Fackler, O; Fujino, D; Lange, D J; Mugge, M; Shi, X; Wenaus, T J; Wright, D M; Wuest, C R; Carroll, M; Fry, J R; Gabathuler, Erwin; Gamet, R; George, M; Kay, M; McMahon, S; McMahon, T R; Payne, D J; Touramanis, C; Aspinwall, M L; Dauncey, P D; Eschrich, I; Gunawardane, N J W; Martin, R D; Nash, J A; Sanders, P; Smith, D; Azzopardi, D E; Back, J J; Dixon, P; Harrison, P F; Vidal, P B; Williams, M I; Cowan, G D; Green, M G; Kurup, A; McGrath, P; Scott, I; Brown, D; Davis, C L; Li, Y; Pavlovich, J; Trunov, A G; Allison, J; Barlow, R J; Boyd, J T; Fullwood, J; Khan, A; Lafferty, G D; Savvas, N; Simopoulos, E T; Thompson, R J; Weatherall, J H; Dallapiccola, C; Farbin, A; Jawahery, A; Lillard, V; Olsen, J; Roberts, D A; Brau, B; Cowan, R; Taylor, F; Yamamoto, R K; Blaylock, G; Flood, K T; Hertzbach, S S; Kofler, R R; Lin, C S; Willocq, S; Wittlin, J; Bloom, P; Britton, D I; Milek, M; Patel, P M; Trischuk, J; Lanni, F; Palombo, F; Bauer, J M; Booke, M; Cremaldi, L M; Kroeger, R A; Reidy, J; Sanders, D; Summers, D J; Arguin, J F; Martin, J P; Nief, J Y; Seitz, R; Taras, P; Woch, A; Zacek, V; Nicholson, H; Sutton, C S; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Piccolo, D; Sciacca, C; Falbo, M; LoSecco, J M; Alsmiller, J R G; Gabriel, T A; Handler, T; Colecchia, F; Dal Corso, F; Michelon, G; Morandin, M; Posocco, M; Stroili, R; Torassa, E; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; La Vaissière, C de; Del Buono, L; Hamon, O; Le Diberder, F R; Leruste, P J; Lory, J; Martínez-Vidal, F; Roos, L; Stark, J; Versille, S; Manfredi, P F; Re, V; Speziali, V; Frank, E D; Gladney, L; Guo, Q H; Panetta, J H; Haire, M J; Judd, D; Paick, K; Turnbull, L; Wagoner, D E; Albert, J; Bula, C; Kelsey, M H; Lü, C; McDonald, K T; Miftakov, V; Schaffner, S F; Smith, A J S; Tumanov, A; Varnes, E W; Cavoto, G; Ferrarotto, F; Ferroni, F; Fratini, K; Lamanna, E; Leonardi, E; Mazzoni, M A; Morganti, S; Piredda, G; Safai-Tehrani, F; Serra, M; Waldi, R; Jacques, P F; Kalelkar, M S; Plano, R J; Adye, T; Egede, U; Franek, B J; Geddes, N I; Gopal, Gian P; Copty, N K; Purohit, M V; Yumiceva, F X; Adam, I; Anthony, P L; Anulli, F; Aston, D; Baird, K G; Bloom, Elliott D; Boyarski, A M; Bulos, F; Calderini, G; Convery, M R; Coupal, D P; Coward, D H; Dorfan, J; Doser, Michael; Dunwoodie, W M; Glanzman, T; Godfrey, G L; Grosso, P; Hewett, J L; Himel, Thomas M; Huffer, M E; Innes, W R; Jessop, C P; Kim, P; Langenegger, U; Leith, D W G S; Luitz, S; Lüth, V; Lynch, H L; Manzin, G; Marsiske, H; Menke, S; Messner, R; Moffeit, K C; Morii, M; Mount, R; Müller, D R; O'Grady, C P; Paolucci, P; Petrak, S; Quinn, Helen R; Ratcliff, B N; Robertson, S H; Rochester, L S; Roodman, A; Schietinger, T; Schindler, R H; Schwiening, J; Sciolla, G; Serbo, V V; Snyder, A; Soha, A; Spanier, S M; Stahl, A; Su, D; Sullivan, M K; Talby, M; Tanaka, H A; Vavra, J; Wagner, S R; Weinstein, A J; Wisniewski, W J; Young, C C; Burchat, Patricia R; Cheng, C H; Kirkby, D; Meyer, T I; Roat, C; De Silva, A; Henderson, R; Bugg, W; Cohn, H; Hart, E; Weidemann, A W; Benninger, T; Izen, J M; Kitayama, I; Lou, X C; Turcotte, M; Bianchi, F; Bóna, M; Di Girolamo, B; Gamba, D; Smol, A V; Zanin, D; Bosisio, L; Della Ricca, G; Lanceri, L; Pompili, A; Poropat, P; Prest, M; Vallazza, E; Vuagnin, G; Panvini, R S; Brown, C M; Jackson, P D; Kowalewski, R V; Roney, J M; Band, H R; Charles, E; Dasu, S; Elmer, P; Johnson, J R; Nielsen, J; Orejudos, W; Pan, Y; Prepost, R; Scott, I J; Walsh, J; Wu Sau Lan; Yu, Z; Zobernig, H

    2000-01-01

    A preliminary study of time dependence of B^0-anti-B^0 oscillations using dilepton events is presented. The flavor of the B meson is determined by the charge sign of the lepton. To separate signal leptons from cascade and fake leptons we have used a method which combines several discriminating variables in a neural network. The time evolution of the oscillations is studied by reconstructing the time difference between the decays of the B mesons produced by the Y(4S) decay. With an integrated luminosity of 7.7 fb-1 collected on resonance by BABAR at the PEP-II asymmetric B Factory, we measure the difference in mass of the neutral B eigenstates, Delta_mB0 to be (0.507+/-0.015+/-0.022) x 10^{12} hbar-s^{-1}.

  18. Non-resonant Higgs-pair production in the b anti bb anti b final state at the LHC

    Energy Technology Data Exchange (ETDEWEB)

    Wardrope, David; Jansen, Eric; Konstantinidis, Nikos; Cooper, Ben; Falla, Rebecca; Norjoharuddeen, Nurfikri [University College London, Department of Physics and Astronomy, London (United Kingdom)

    2015-05-15

    We present a particle-level study of the Standard Model non-resonant Higgs-pair production process in the b anti bb anti b final state, at the Large Hadron Collider at √(s) = 14 TeV. Each Higgs boson is reconstructed from a pair of close-by jets formed with the anti-k{sub t} jet clustering algorithm, with radius parameter R = 0.4. Given the kinematic properties of the produced Higgs bosons, this Higgs reconstruction approach appears to be more suitable than the use of largeradius jets that was previously proposed in the literature.We find that the sensitivity for observing this final state can be improved significantly when the full set of uncorrelated angular and kinematic variables of the 4b system is exploited, leading to a statistical significance of 1.8 per experiment with an integrated luminosity of 3 ab{sup -1}. (orig.)

  19. In what ways do the experiences of students in PhD programs in the molecular biosciences foster knowledge transfer?

    Science.gov (United States)

    Prevost, Amy C.

    Doctoral training in the molecular biosciences often fails to prepare students for academic and alternate careers. Several studies of doctoral training have reported a need to improve doctoral education; outlining specific criticisms related to the need to broaden the scope of the doctoral degree in order to prepare students for careers. The development of doctoral students' knowledge transfer skills is the key to making this transition. The theory advanced in this study extends the literature on doctoral education related to student experiences that foster the development of knowledge transfer skills. These insights will be a resource for academic leaders as they develop new programs and the re-develop existing ones; to students and graduates as they become leaders in their field; and to mentors, who have a large role in the development of doctoral students. Research conducted for this dissertation led to the development of theory about elements of the doctoral experience that foster the development of knowledge transfer skills in the molecular biosciences. In exploring ways the experiences of students in PhD programs in the molecular biosciences foster knowledge transfer, I was able to develop a framework for understanding these experiences in the context of doctoral programs. Students' experiences are affected by different elements of doctoral education. As they develop identities as researchers and scientists, and transition from novices to experts, students' experiences are shaped by their mentors, peers, programs and departments. Subjects spoke about their experiences in interviews. This study exposed a need to balance support and challenge for doctoral students to allow them to develop the capacity to perform scientific research and act as leaders. The development of knowledge transfer skills within this context is important preparation for students in the molecular biosciences. Doctoral students in this area need to apply their expertise in increasingly

  20. Boosted Higgs → b anti b in vector-boson associated production at 14 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Butterworth, Jonathan M.; Ochoa, Ines; Scanlon, Tim [University College London, Department of Physics and Astronomy, London (United Kingdom)

    2015-08-15

    The production of the Standard Model Higgs boson in association with a vector boson, followed by the dominant decay to H → b anti b, is a strong prospect for confirming and measuring the coupling to b-quarks in pp collisions at √(s) = 14 TeV. We present an updated study of the prospects for this analysis, focussing on the most sensitive highly Lorentz-boosted region. The evolution of the efficiency and composition of the signal and main background processes as a function of the transverse momentum of the vector boson are studied covering the region 200-1000 GeV, comparing both a conventional dijet and jet substructure selection. The lower transverse momentum region (200-400 GeV) is identified as the most sensitive region for the Standard Model search, with higher transverse momentum regions not improving the statistical sensitivity. For much of the studied region (200-600 GeV), a conventional dijet selection performs as well as the substructure approach, while for the highest transverse momentum regions (>600 GeV), which are particularly interesting for Beyond the Standard Model and high luminosity measurements, the jet substructure techniques are essential. (orig.)

  1. Scale dependence of open c anti c and b anti b production in the low x region

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, E.G. de [Universidade Federal de Santa Catarina, Departamento de Fisica, CFM, C.P. 476, Florianopolis, SC (Brazil); University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); Martin, A.D. [University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); Ryskin, M.G. [University of Durham, Institute for Particle Physics Phenomenology, Durham (United Kingdom); NRC Kurchatov Institute, Petersburg Nuclear Physics Institute, St. Petersburg (Russian Federation)

    2017-03-15

    The 'optimal' factorization scale μ{sub 0} is calculated for open heavy quark production. We find that the optimal value is μ{sub F} = μ{sub 0} ≅ 0.85√(p{sup 2}{sub T}+m{sub Q}{sup 2}); a choice which allows us to resum the double-logarithmic, (α{sub s} ln μ{sup 2}{sub F} ln (1/x)){sup n} corrections (enhanced at LHC energies by large values of ln(1/x)) and to move them into the incoming parton distributions, PDF (x, μ{sub 0}{sup 2}). Besides this result for the single inclusive cross section (corresponding to an observed heavy quark of transverse momentum p{sub T}), we also determined the scale for processes where the acoplanarity can be measured; that is, events where the azimuthal angle between the quark and the antiquark may be determined experimentally. Moreover, we discuss the important role played by the 2 → 2 subprocesses, gg → Q anti Q at NLO and higher orders. In summary, we achieve a better stability of the QCD calculations, so that the data on c anti c and b anti b production can be used to further constrain the gluons in the small x, relatively low scale, domain, where the uncertainties of the global analyses are large at present. (orig.)

  2. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab (MHB)

  3. The impact of attaining the Welsh Baccalaureate Advanced Diploma on academic performance in bioscience higher education

    Science.gov (United States)

    Yhnell, Emma; Wood, Heather; Baker, Mathew; Amici-Dargan, Sheila; Taylor, Chris; Randerson, Peter; Shore, Andrew

    2016-01-01

    Since the introduction of the Welsh Baccalaureate Advanced Diploma Qualification (WBQ) in 2003, an increasing number of students are applying to higher education institutions (HEIs) with this qualification. The advanced-level WBQ is regarded as equivalent to one General Certificate of Education A-Level (GCE A-Level). This study assesses the impact of attaining the WBQ in addition to three GCE A-Levels on overall university degree performance in comparison to attaining four GCE A-Levels, in three cohorts of undergraduate students (Year 1 = 318, Year 2 = 280, Year 3 = 236) studying Biosciences from 2005 to 2011 at a UK HEI. Binary logistic regression was used to compare the academic attainment of students who had achieved four GCE A-Levels to those who had achieved three GCE A-Levels in addition to the WBQ. Comparisons were also made between students who had achieved three GCE A-Levels and those who had achieved three GCE A-Levels in addition to the WBQ. The results suggest that students who achieved the WBQ qualification in its current form, in addition to three GCE A-Levels, performed less well academically in undergraduate studies than those who achieved four GCE A-Levels. Furthermore, this effect was still present when the balance between coursework and examination was considered, and when students who had achieved the WBQ in addition to three GCE A-Levels were compared to students who had achieved three GCE A-Levels.

  4. Combined analysis of cross-reacting antibodies anti-β1AR and anti-B13 in advanced stages of Chagas heart disease.

    Science.gov (United States)

    Rodeles, Luz M; Vicco, Miguel H; Bontempi, Iván A; Siano, Alvaro; Tonarelli, Georgina; Bottasso, Oscar A; Arias, Pablo; Marcipar, Iván S

    2016-12-01

    Autoantibodies cross-reacting with the β1 adrenergic receptor (anti-β1AR and anti-p2β) and cardiac myosin antigens (anti-B13) have been related to the pathogenesis of chronic Chagas heart disease (CCHD). Studies exploring their levels in different stages are scarce. We aimed to evaluate the relationship of these autoantibodies with the clinical profile of chronic patients, especially regarding their classificatory accuracy in severe presentation with heart failure. We conducted a cross-sectional study of 155 T. cruzi-seropositive patients and 26 age- and gender-matched healthy controls. They were categorised in three stages of CCHD. Serum antibodies were measured by specific immunoassays. Symptomatic individuals showed increased levels of anti-β1AR and anti-B13, while anti-p2β antibodies were similar between groups. A composite logistic regression model including anti-B13, anti-β1AR antibody levels and age was able to predict systolic heart failure yielding an area under the curve of 83% (sensitivity of 67% and specificity of 89%). In our study, anti-β1AR and anti-B13 antibodies were higher in individuals with chronic Chagas heart disease stage III, mainly in those with dilated cardiomyopathy associated with systolic heart failure. Logistic regression analysis showed that both antibodies were good predictors of severe CCHD. As well as being involved in disease progression, anti-β1AR and anti-B13 antibodies may be used as a serum marker of poor prognosis in terms of heart compromise. © 2016 John Wiley & Sons Ltd.

  5. The decays anti B → anti K{sup (*)}l{sup +}l{sup -} at low recoil and their constraints on new physics

    Energy Technology Data Exchange (ETDEWEB)

    Dyk, Danny van

    2012-07-15

    In this thesis we test the validity of the Standard Model of particle physics by studying the exclusive rare decays anti B → anti K{sup (*)}l{sup +}l{sup -}. We calculate the angular distribution of the decay anti B → anti K{sup (*)}l{sup +}l{sup -} in the most general basis of effective operators. We obtain results for the angular distribution in the kinematic region of low hadronic recoil. Based on our results for the angular distribution, we propose observables which exhibit no or only very weak dependence on hadronic matrix elements. Beyond CP-averaged observables, we also investigate direct and mixing induced CP asymmetries at low hadronic recoil. We conclude our investigation of exclusive decays by studying the decay anti B → anti Kl{sup +}l{sup -}, where we find a relation between the CP asymmetry of the rates of anti B → anti K{sup (*)}l{sup +}l{sup -}. Standard model results for a majority of our analytic results are given. Beyond that, we perform a model-independent analysis based on available experimental data and obtain constraints on the Wilson coefficients C{sub 9} and C{sub 10}, as well as lower bounds on the zero-crossing in the anti B → anti K*l{sup +}l{sup -} forward-backward asymmetry. Based on recent LHC data we find two disjoint solutions for the Wilson coefficients. One of the solutions is in good agreement with the Standard Model, but sizable deviations are still allowed.

  6. Freqüência de hemolisinas anti-A e anti-B em doadores de sangue de Itapeva e Ourinhos Anti-A and anti-B hemolysin frequencies in blood donors from Itapeva and Ourinhos

    Directory of Open Access Journals (Sweden)

    Vanessa C. Fernandes

    2008-12-01

    Full Text Available Uma transfusão de sangue com o tipo ABO incorreto pode resultar na morte do paciente, com reação hemolítica intravascular, seguida de alterações imunológicas e bioquímicas. Considerando a pequena quantidade de estudos sobre as hemolisinas anti-A e anti-B e a importância desses anticorpos na prática transfusional, o objetivo deste trabalho foi verificar a frequência dessas hemolisinas e a associação a fatores como etnia e gênero em doadores de sangue dos bancos de sangue dos municípios de Itapeva e de Ourinhos, no interior do estado de São Paulo. Foram analisadas todas as amostras de doadores tipo O cadastradas nos bancos de sangue, com elevado nível plasmático de hemolisinas (doadores considerados perigosos. Coletaram-se os dados relativos à frequência das hemolisinas, etnia, gênero e procedência destes doadores. A frequência de doadores de sangue do grupo sanguíneo O perigosos é de 1,2% em Itapeva e de 5,3% em Ourinhos. Na cidade de Ourinhos, o risco de um doador branco ter hemolisina positiva é 2,16 vezes maior do que para outros doadores, e na cidade de Itapeva notou-se que o risco é menor para brancos do que para outros doadores. Em relação ao gênero, em Ourinhos o risco de um doador ter hemolisina positiva é 1,82 vezes maior para o gênero masculino, e na cidade de Itapeva, o risco foi maior para doadores do gênero feminino. A relação entre o gênero, a etnia e a frequência de hemolisinas foi diferente nas duas cidades. Mesmo assim, destaca-se a importância dos bancos de sangue estarem atentos às características de prevalência deste tipo de doador.Blood transfusion using unmatched ABO blood types can result in patient death due to intravascular hemolytic reactions followed by immunological and biochemical changes. Considering the small number of studies on anti-A and anti-B hemolysins and the relevance of these antibodies in the transfusional practice, this work aimed at assessing the frequency of

  7. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  8. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends; SBBN 2010: 7. Congresso da Sociedade Brasileira de Biociencias Nucleares. Radiacoes em biociencias: avancos e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  9. States of ρB{sup *} anti B{sup *} with J = 3 within the fixed center approximation to Faddeev equations

    Energy Technology Data Exchange (ETDEWEB)

    Bayar, M. [Kocaeli University, Department of Physics, Izmit (Turkey); Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica and IFIC, Aptdo. 22085, Valencia (Spain); Fernandez-Soler, P.; Sun, Zhi-Feng; Oset, E. [Centro Mixto Universidad de Valencia-CSIC, Institutos de Investigacion de Paterna, Departamento de Fisica Teorica and IFIC, Aptdo. 22085, Valencia (Spain)

    2016-04-15

    In this work we study the ρB{sup *} anti B{sup *} three-body system solving the Faddeev equations in the fixed center approximation. We assume the B{sup *} anti B{sup *} system forming a cluster, and in terms of the two-body ρB{sup *} unitarized scattering amplitudes in the local hidden gauge approach we find a new I(J{sup PC}) = 1(3{sup -}) state. The mass of the new state corresponds to a two-particle invariant mass of the ρB{sup *} system close to the resonant energy of the *, indicating that the role of this J = 2 resonance is important in the dynamical generation of the new state. (orig.)

  10. A measurement of the $B^{0}-anti-B^{0}$ oscillation frequency and determination of flavor-tagging efficiency using semileptonic and hadronic $B^{0}$ decays

    CERN Document Server

    Aubert, Bernard; Boutigny, D; De Bonis, I; Favier, Jean; Gaillard, Jean-Marc; Galeazzi, F; Jérémie, A; Karyotakis, Yu; Lees, J P; Robbe, P; Tisserand, V; Zachariadou, K; Palano, A; Chen, G P; Chen Jia Chao; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Reinertsen, P L; Stugu, B; Abbott, B; Abrams, G S; Borgland, A W; Breon, A B; Brown, D N; Button-Shafer, J; Cahn, R N; Clark, A R; Fan, Q; Gill, M S; Gowdy, S J; Groysman, Y; Jacobsen, R G; Kadel, R W; Kadyk, J A; Kerth, L T; Kluth, S; Kral, J F; Leclerc, C; Levi, M E; Liu, T; Lynch, G; Meyer, A B; Momayezi, M; Oddone, P J; Perazzo, A; Pripstein, M; Roe, N A; Romosan, A; Ronan, Michael T; Shelkov, V G; Strother, P; Telnov, A V; Wenzel, W A; Champion, T J; Hawkes, C M; Kirk, A; O'Neale, S W; Watson, A T; Watson, N K; Koch, H; Krug, J; Kunze, M; Lewandowski, B; Peters, K; Schmücker, H; Steinke, M; Andress, J C; Chevalier, N; Clark, P J; Cottingham, N; De Groot, N; Dyce, N; Foster, B; Mass, A; McFall, J D; Wallom, D; Wilson, F F; Abe, K; Hearty, C; Mattison, T S; McKenna, J A; Thiessen, D; Camanzi, B; McKemey, A K; Tinslay, J; Blinov, V E; Bukin, A D; Bukin, D A; Buzykaev, A R; Dubrovin, M S; Golubev, V B; Ivanchenko, V N; Korol, A A; Kravchenko, E A; Onuchin, A P; Salnikov, A A; Serednyakov, S I; Skovpen, Yu I; Yushkov, A N; Lankford, A J; Mandelkern, M A; Stoker, D P; Ahsan, A; Arisaka, K; Buchanan, C D; Chun, S; Branson, J G; Faccini, R; MacFarlane, D B; Rahatlou, S; Raven, G; Sharma, V; Campagnari, C; Dahmes, B; Hart, P A; Kuznetsova, N P; Levy, S L; Long, O; Lu, A; Richman, J D; Verkerke, W; Witherell, M; Yellin, S; Beringer, J; Dorfan, D E; Eisner, A M; Frey, A; Grillo, A A; Grothe, M; Heusch, C A; Johnson, R P; Kröger, W; Lockman, W S; Pulliam, T; Sadrozinski, H F W; Schalk, T L; Schmitz, R E; Schumm, B A; Seiden, A; Turri, M; Williams, D C; Chen, E; Dubois-Felsmann, G P; Dvoredsky, A P; Hitlin, D G; Kolomensky, Yu G; Metzler, S; Oyang, J Y T; Porter, F C; Ryd, A; Samuel, A; Weaver, M; Yang, S; Zhu, R Y; Aleksan, Roy; De Domenico, G; de Lesquen, A; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Langer, M; London, G W; Mayer, B; Serfass, B; Vasseur, G; Yéche, C; Zito, M; Devmal, S C; Geld, T L; Jayatilleke, S M; Mancinelli, G; Meadows, B T; Sokoloff, M D; Blouw, J; Harton, J L; Krishnamurthy, M; Soffer, A; Toki, W H; Wilson, R J; Zhang, J; Fahey, S; Ford, W T; Gaede, F; Johnson, D R; Michael, A K; Nauenberg, U; Olivas, A; Park, H; Rankin, P; Roy, J D; Sen, S; Smith, J G; Wagner, D L; Brandt, T; Brose, J; Dahlinger, G; Dickopp, M; Dubitzky, R S; Kocian, M L; Müller-Pfefferkorn, R; Schubert, Klaus R; Schwierz, R; Spaan, B; Wilden, L; Behr, L; Bernard, D; Bonneaud, G R; Brochard, F; Cohen-Tanugi, J; Ferrag, S; Roussot, E; Thiebaux, C; Vasileiadis, G; Verderi, M; Anjomshoaa, A; Bernet, R; Di Lodovico, F; Muheim, F; Playfer, S; Swain, J E; Bozzi, C; Dittongo, S; Folegani, M; Piemontese, L; Treadwell, E A; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Falciai, D; Finocchiaro, G; Patteri, P; Peruzzi, I M; Piccolo, M; Zallo, A; Bagnasco, S; Buzzo, A; Contri, R; Crosetti, G; Fabbricatore, P; Farinon, S; Lo Vetere, M; Macri, M; Monge, M R; Musenich, R; Parodi, R; Passaggio, S; Pastore, F; Patrignani, C; Pia, M G; Priano, C; Robutti, E; Santroni, A; Cochran, J; Crawley, H B; Fischer, P A; Lamsa, J; Meyer, W T; Rosenberg, E I; Bartoldus, R; Dignan, T; Hamilton, R; Mallik, U; Angelini, C; Batignani, G; Bettarini, S; Bondioli, M; Carpinelli, M; Forti, F; Giorgi, M A; Lusiani, A; Morganti, M; Paoloni, E; Rama, M; Rizzo, G; Sandrelli, F; Simi, G; Triggiani, G; Benkebil, M; Grosdidier, G; Hast, C; Höcker, A; Le Peltier, V; Lutz, A M; Plaszczynski, S; Schune, M H; Trincaz-Duvoid, S; Valassi, Andrea; Wormser, G; Bionta, R M; Brigljevic, V; Fackler, O; Fujino, D; Lange, D J; Mugge, M; Shi, X; Wenaus, T J; Wright, D M; Wuest, C R; Carroll, M; Fry, J R; Gabathuler, Erwin; Gamet, R; George, M; Kay, M; McMahon, S; McMahon, T R; Payne, D J; Touramanis, C; Aspinwall, M L; Dauncey, P D; Eschrich, I; Gunawardane, N J W; Martin, R D; Nash, J A; Sanders, P; Smith, D; Azzopardi, D E; Back, J J; Dixon, P; Harrison, P F; Vidal, P B; Williams, M I; Cowan, G D; Green, M G; Kurup, A; McGrath, P; Scott, I; Brown, D; Davis, C L; Li, Y; Pavlovich, J; Trunov, A G; Allison, J; Barlow, R J; Boyd, J T; Fullwood, J; Khan, A; Lafferty, G D; Savvas, N; Simopoulos, E T; Thompson, R J; Weatherall, J H; Dallapiccola, C; Farbin, A; Jawahery, A; Lillard, V; Olsen, J; Roberts, D A; Brau, B; Cowan, R; Taylor, F; Yamamoto, R K; Blaylock, G; Flood, K T; Hertzbach, S S; Kofler, R R; Lin, C S; Willocq, S; Wittlin, J; Bloom, P; Britton, D I; Milek, M; Patel, P M; Trischuk, J; Lanni, F; Palombo, F; Bauer, J M; Booke, M; Cremaldi, L M; Kroeger, R A; Reidy, J; Sanders, D; Summers, D J; Arguin, J F; Martin, J P; Nief, J Y; Seitz, R; Taras, P; Woch, A; Zacek, V; Nicholson, H; Sutton, C S; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Piccolo, D; Sciacca, C; Falbo, M; LoSecco, J M; Alsmiller, J R G; Gabriel, T A; Handler, T; Colecchia, F; Dal Corso, F; Michelon, G; Morandin, M; Posocco, M; Stroili, R; Torassa, E; Voci, C; Benayoun, M; Briand, H; Chauveau, J; David, P; La Vaissière, C de; Del Buono, L; Hamon, O; Le Diberder, F R; Leruste, P J; Lory, J; Martínez-Vidal, F; Roos, L; Stark, J; Versille, S; Manfredi, P F; Re, V; Speziali, V; Frank, E D; Gladney, L; Guo, Q H; Panetta, J H; Haire, M J; Judd, D; Paick, K; Turnbull, L; Wagoner, D E; Albert, J; Bula, C; Kelsey, M H; Lü, C; McDonald, K T; Miftakov, V; Schaffner, S F; Smith, A J S; Tumanov, A; Varnes, E W; Cavoto, G; Ferrarotto, F; Ferroni, F; Fratini, K; Lamanna, E; Leonardi, E; Mazzoni, M A; Morganti, S; Piredda, G; Safai-Tehrani, F; Serra, M; Waldi, R; Jacques, P F; Kalelkar, M S; Plano, R J; Adye, T; Egede, U; Franek, B J; Geddes, N I; Gopal, Gian P; Copty, N K; Purohit, M V; Yumiceva, F X; Adam, I; Anthony, P L; Anulli, F; Aston, D; Baird, K G; Bloom, Elliott D; Boyarski, A M; Bulos, F; Calderini, G; Convery, M R; Coupal, D P; Coward, D H; Dorfan, J; Doser, Michael; Dunwoodie, W M; Glanzman, T; Godfrey, G L; Grosso, P; Hewett, J L; Himel, Thomas M; Huffer, M E; Innes, W R; Jessop, C P; Kim, P; Langenegger, U; Leith, D W G S; Luitz, S; Lüth, V; Lynch, H L; Manzin, G; Marsiske, H; Menke, S; Messner, R; Moffeit, K C; Morii, M; Mount, R; Müller, D R; O'Grady, C P; Paolucci, P; Petrak, S; Quinn, Helen R; Ratcliff, B N; Robertson, S H; Rochester, L S; Roodman, A; Schietinger, T; Schindler, R H; Schwiening, J; Sciolla, G; Serbo, V V; Snyder, A; Soha, A; Spanier, S M; Stahl, A; Su, D; Sullivan, M K; Talby, M; Tanaka, H A; Vavra, J; Wagner, S R; Weinstein, A J; Wisniewski, W J; Young, C C; Burchat, Patricia R; Cheng, C H; Kirkby, D; Meyer, T I; Roat, C; De Silva, A; Henderson, R; Bugg, W; Cohn, H; Hart, E; Weidemann, A W; Benninger, T; Izen, J M; Kitayama, I; Lou, X C; Turcotte, M; Bianchi, F; Bóna, M; Di Girolamo, B; Gamba, D; Smol, A V; Zanin, D; Bosisio, L; Della Ricca, G; Lanceri, L; Pompili, A; Poropat, P; Prest, M; Vallazza, E; Vuagnin, G; Panvini, R S; Brown, C M; Jackson, P D; Kowalewski, R V; Roney, J M; Band, H R; Charles, E; Dasu, S; Elmer, P; Johnson, J R; Nielsen, J; Orejudos, W; Pan, Y; Prepost, R; Scott, I J; Walsh, J; Wu Sau Lan; Yu, Z; Zobernig, H

    2000-01-01

    B^0-anti-B^0 flavor oscillations are studied in e^+e^- annihilation data collected with the BABAR detector at center-of-mass energies near the Y(4S) resonance. One B is reconstructed in a hadronic or semileptonic decay mode, and the flavor of the other B in the event is determined with a tagging algorithm that exploits the relation between the flavor of the heavy quark and the charges of its decay products. Tagging performance is characterized by an efficiency e_i and a probability for mis-identification, w_i, for each tagging category. We report a determination of the wrong-tag probabilities, w_i, and a preliminary result for the time-dependent B^0-anti-B^0 oscillation frequency, Delta_md = 0.512+/-0.017+/-0.022 hbar-ps^{-1}.

  11. [The possibilities for using anti-A, anti-B and anti-H immunoreagents obtained by new technology in direct and indirect immunofluorescence reactions].

    Science.gov (United States)

    Iudina, G S; Zaretskaia, E F

    1999-01-01

    The authors propose to prepare group-specific immunoreagents anti-A, anti-B, and anti-H for direct and indirect immunofluorescence from non-precipitated antisera of the appropriate specificities by a new technology making use of routine bioadsorbents and synthetic oligosaccharides. The method has been developed at Research Center of Forensic Medical Expert Evaluations of the Russian Ministry of Health. The immunoreagents were tried on a vast scope of experimental and expert specimens at several institutions.

  12. A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

    Directory of Open Access Journals (Sweden)

    Quail Michael A

    2012-07-01

    Full Text Available Abstract Background Next generation sequencing (NGS technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’ RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. Results Sequence generated by Ion Torrent, MiSeq and Pacific Biosciences technologies displays near perfect coverage behaviour on GC-rich, neutral and moderately AT-rich genomes, but a profound bias was observed upon sequencing the extremely AT-rich genome of Plasmodium falciparum on the PGM, resulting in no coverage for approximately 30% of the genome. We analysed the ability to call variants from each platform and found that we could call slightly more variants from Ion Torrent data compared to MiSeq data, but at the expense of a higher false positive rate. Variant calling from Pacific Biosciences data was possible but higher coverage depth was required. Context specific errors were observed in both PGM and MiSeq data, but not in that from the Pacific Biosciences platform. Conclusions All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support.

  13. B{sub s}{sup 0}- anti B{sub s}{sup 0} mixing within minimal flavor-violating two-Higgs-doublet models

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Qin [Henan Normal University, Institute of Particle and Nuclear Physics, Xinxiang, Henan (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Li, Pei-Fu [Henan Normal University, Institute of Particle and Nuclear Physics, Xinxiang, Henan (China); Li, Xin-Qiang [Central China Normal University, Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics (MOE), Wuhan, Hubei (China); Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Beijing (China)

    2015-12-15

    In the ''Higgs basis'' for a generic 2HDM, only one scalar doublet gets a nonzero vacuum expectation value and, under the criterion of minimal flavor violation, the other one is fixed to be either color-singlet or color-octet, which are named as the type-III and type-C models, respectively. In this paper, the charged-Higgs effects of these two models on B{sub s}{sup 0}- anti B{sub s}{sup 0} mixing are studied. First of all, we perform a complete one-loop computation of the electro-weak corrections to the amplitudes of B{sub s}{sup 0}- anti B{sub s}{sup 0} mixing. Together with the up-to-date experimental measurements, a detailed phenomenological analysis is then performed in the cases of both real and complex Yukawa couplings of charged scalars to quarks. The spaces of model parameters allowed by the current experimental data on B{sub s}{sup 0}- anti B{sub s}{sup 0} mixing are obtained and the differences between type-III and type-C models are investigated, which is helpful to distinguish between these two models. (orig.)

  14. A measurement of the B{sup 0} anti B{sup 0} mixing parameter at LEP using a neural network

    Energy Technology Data Exchange (ETDEWEB)

    Los, M.E.

    1995-11-27

    In this thesis the B{sup 0}- anti B{sup 0} mixing parameter {chi} is measured. The data have been collected using the DELPHI detector at the electron-positron accelerator LEP at CERN in Geneva. At the LEP energy of about 91 GeV the Z{sup 0} particle is produced. About 15 percent of the time the Z{sup 0} decays into a b anti b-pair, which makes LEP an ideal environment to study the properties of the heavy b quark. In this thesis, the signal for the measurement of {chi} consists of events in which there are two leptons in the final state. If both leptons directly originate from a b quark decay (b{yields}l), then their charge reflects the one of the b quark. Events with leptons of the same sign indicate the presence of B{sup 0}- anti B{sup 0} mixing. The neural network variable achieves a better separation between the signal and the background than the transverse moemntum. Using data recorded by DELPHI in 1992, one obtains for the mixing parameter {chi}=8.6%{+-}2.3%(stat){+-}0.6%(sys). (orig./WL).

  15. Reflective writing as a tool for assessing teamwork in bioscience: insights into student performance and understanding of teamwork.

    Science.gov (United States)

    Mayne, Lynne

    2012-07-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly evolving competitive work place and align with the needs of industry. This creates a challenge, how do we develop generic capabilities without losing discipline content. This report analyses teamwork projects embedded in an undergraduate Biotechnology degree designed to promote teamwork skills along with a deeper understanding of the underpinning biochemistry. Student reflective writing was used to capture students' understanding and experience of teamwork as well as provide insight into their metacognition. The analysis demonstrates that 73% of Year 3 and 93% of Year 4 students were capable of learning about teamwork through reflective writing. While the importance of frequent high quality communication was a common theme, evidence suggests that many students were unsophisticated in their use of communication software. The analysis also highlighted the depth of metacognition that underpins successful team function and the significant weaknesses in self-insight some students possess. These findings challenge assumptions regarding student capacity for leadership and the ability of some students to contribute to successful team outcomes. It is essential for the design of teamwork experiences to fully understand the competencies that underlie teamwork, the metacognitive processes required, and ensure that assessments are fair and measure individual academic performance.

  16. A Search For The Z → b anti-b Process at The D-Zero Experiment

    Energy Technology Data Exchange (ETDEWEB)

    Jenkins, Amber Helen [Imperial College, London (United Kingdom)

    2006-11-01

    In 2001, the D0 experiment entered a new era. Run II of the Tevatron at the Fermi National Accelerator Laboratory began, and the collider became the highest energy particle accelerator in the world. Accordingly, the D0 detector had already undergone a series of upgrades in order to fully exploit the physics now within reach. These included improvements to the tracking, calorimetry, muon detection and triggering capabilities. In the Standard Model, the Higgs boson is the last piece of the puzzle that remains to be discovered. The Higgs mechanism and consequently the Higgs boson is thought to be the fundamental ingredient by which particles acquire mass, and its existence (or lack of existence) is one of the most pressing issues in particle physics today. As such, one of the main goals of the Run II physics programme at D0 is to search for it. Armed with new accelerator capabilities, D0 will be able to impose tighter constraints on the mass of the Higgs, and perhaps even detect this elusive particle. If the Higgs does exist, it will be extremely difficult to find. One of the main challenges at a hadron-hadron collider is to reduce the large QCD background that masks the relatively tiny Higgs signal. Experimental evidence indicates that the Higgs mass is relatively low, in which case it will decay predominantly to a b$\\bar{b}$ quark-antiquark pair. The daughter products that must be used to reconstruct the parent Higgs are therefore likely to be heavy flavour b-quark jets whose energies must be known as accurately as possible. In the first part of this thesis consideration is given to these jets, in particular to the jet energy resolution and dijet mass resolution that they could offer. One way of investigating the necessary tools for such a Higgs search is to study a very similar decay to that of a low-mass Higgs particle: a Z boson decaying to a b quark and an anti-b-quark. This signal, not previously observed at the Tevatron, offers an ideal testbed in which to

  17. Bioculture System: Expanding ISS Space Bioscience Capabilities for Fundamental Stem Cell Research and Commercial Applications

    Science.gov (United States)

    Blaber, Elizabeth; Dvorochkin, Natalya; Almeida, Eduardo; Fitzpatrick, Garret; Ellingson, Lance; Mitchell, Sarah; Yang, Anthony; Kosnik, Cristine; Rayl, Nicole; Cannon, Tom; Austin, Edward; Sato, Kevin

    With the recent call by the 2011 Decadal Report and the 2010 Space Biosciences Roadmap for the International Space Station (ISS) to be used as a National Laboratory for scientific research, there is now a need for new laboratory instruments on ISS to enable such research to occur. The Bioculture System supports the extended culturing of multiple cell types and microbiological specimens. It consists of a docking station that carries ten independent incubation units or ‘Cassettes’. Each Cassette contains a cooling chamber (5(°) C) for temperature sensitive solutions and samples, or long duration fluids and sample storage, as well as an incubation chamber (ambient up to 42(°) C). Each Cassette houses an independent fluidics system comprised of a biochamber, medical-grade fluid tubing, medium warming module, oxygenation module, fluid pump, and sixteen solenoid valves for automated biochamber injections of sampling. The Bioculture System provides the user with the ability to select the incubation temperature, fluid flow rate and automated biochamber sampling or injection events for each separate Cassette. Furthermore, the ISS crew can access the biochamber, media bag, and accessory bags on-orbit using the Microgravity Science Glovebox. The Bioculture System also permits initiation of cultures, subculturing, injection of compounds, and removal of samples for on-orbit processing using ISS facilities. The Bioculture System therefore provides a unique opportunity for the study of stem cells and other cell types in space. The first validation flight of the Bioculture System will be conducted on SpaceX5, consisting of 8 Cassettes and lasting for 30-37 days. During this flight we plan to culture two different mammalian cell types in bioreactors: a mouse osteocytic-like cell line, and human induced pluripotent stem cell (iPS)-derived cardiomyocytes. Specifically, the osteocytic line will enable the study of a type of cell that has been flown on the Bioculture System

  18. New physics contributions to anti B{sub s} → π{sup 0}(ρ{sup 0})η{sup (')} decays

    Energy Technology Data Exchange (ETDEWEB)

    Faisel, Gaber [Sueleyman Demirel University, Department of Physics, Faculty of Arts and Sciences, Isparta (Turkey); National Taiwan University, Department of Physics, Taipei (China)

    2017-06-15

    The decay modes anti B{sub s} → π{sup 0}(ρ{sup 0})η{sup (')} are dominated by electroweak penguins that are small in the standard model. In this work we investigate the contributions to these penguins from a model with an additional U(1){sup '} gauge symmetry and show there effects on the branching ratios of anti B{sub s} → π{sup 0}(ρ{sup 0})η{sup (')}. In a scenario of the model, where Z{sup '} couplings to the left-handed quarks vanish, we show that the maximum enhancement occurs in the branching ratio of anti B{sub s}{sup 0} → π{sup 0}η{sup '} where it can reach 6 times the SM prediction. On the other hand, in a scenario of the model where Z{sup '} couplings to both left-handed and right-handed quarks do not vanish, we find that Z{sup '} contributions can enhance the branching ratio of B{sup 0}{sub s} → ρ{sup 0}η up to one order of magnitude comparing to the SM prediction for several sets of the parameter space where both ΔM{sub B{sub s}} and S{sub ψφ} constraints are satisfied. This kind of enhancement occurs for a rather fine-tuned point where the ΔM{sub B{sub s}} constraint on vertical stroke S{sub SM}(B{sub s}) + S{sub Z}{sup {sub '}} (B{sub s}) vertical stroke is fulfilled by overcompensating the SM via S{sub Z}{sup {sub '}}(B{sub s}) ≅ -2S{sub SM}(B{sub s}). (orig.)

  19. A qualitative study of the relationship of personality type with career management and career choice preference in a group of bioscience postgraduate students and postdoctoral researchers

    OpenAIRE

    Blackford, Sarah

    2010-01-01

    This study reports on the career management and career choice preferences of a sample of bioscience postgraduate students and postdoctoral researchers according to their personality type as determined using the Myers Briggs Type Indicator (MBTI). Correlations can be found but other decision-making processes come into play and are more influential regarding career choices

  20. Teaching a Dyslexic Student: A Personal View How Critical Incident Analysis Can Be Used as an Effective Pedagogical Tool in Undergraduate Biosciences

    Science.gov (United States)

    Ahluwalia, Jatinder

    2009-01-01

    This paper examines the concept of critical incident analysis in respect of improving the pedagogical practices in teaching dyslexic undergraduate biosciences students. Critical incident analysis is a well established pedagogical theory (Tripp, 1993) that allows reflection of a seemingly typical incident; the "critical incident", so that changes…

  1. A qualitative study of the relationship of personality type with career management and career choice preference in a group of bioscience postgraduate students and postdoctoral researchers

    OpenAIRE

    Blackford, Sarah

    2010-01-01

    This study reports on the career management and career choice preferences of a sample of bioscience postgraduate students and postdoctoral researchers according to their personality type as determined using the Myers Briggs Type Indicator (MBTI). Correlations can be found but other decision-making processes come into play and are more influential regarding career choices

  2. Lowest-lying even-parity anti B{sub s} mesons: heavy-quark spin-flavor symmetry, chiral dynamics, and constituent quark-model bare masses

    Energy Technology Data Exchange (ETDEWEB)

    Albaladejo, M.; Fernandez-Soler, P.; Nieves, J.; Ortega, P.G. [Centro Mixto CSIC-Universidad de Valencia, Instituto de Fisica Corpuscular (IFIC), Institutos de Investigacion de Paterna, Aptd. 22085, Valencia (Spain)

    2017-03-15

    The discovery of the D{sup *}{sub s0}(2317) and D{sub s1}(2460) resonances in the charmed-strange meson spectra revealed that formerly successful constituent quark models lose predictability in the vicinity of two-meson thresholds. The emergence of non-negligible effects due to meson loops requires an explicit evaluation of the interplay between Q anti q and (Q anti q)(q anti q) Fock components. In contrast to the c anti s sector, there is no experimental evidence of J{sup P} = 0{sup +}, 1{sup +} bottom-strange states yet. Motivated by recent lattice studies, in this work the heavy-quark partners of the D{sub s0}{sup *}(2317) and D{sub s1}(2460) states are analyzed within a heavy meson chiral unitary scheme. As a novelty, the coupling between the constituent quark-model P-wave anti B{sub s} scalar and axial mesons and the anti B{sup (*)}K channels is incorporated employing an effective interaction, consistent with heavy-quark spin symmetry, constrained by the lattice energy levels. (orig.)

  3. Iodine-131 Tositumomab: (131)I-anti-B1 antibody, (131)I-tositumomab, anti-CD20 murine monoclonal antibody-I-131, B1, Bexxar, (131)I-anti-B1 antibody, iodine-131 tositumomab, iodine-131 anti-B1 antibody, tositumomab.

    Science.gov (United States)

    2003-01-01

    Iodine-131 tositumomab [B1, Bexxar , iodine-131 anti-B1 antibody] is a murine antibody conjugated to iodine 131 that recognises and binds to the B1 (CD20) antigen which is found specifically on B lymphocytes. Iodine-131 tositumomab has a dual mechanism of action. It is capable of initiating a host immune response to those B cells to which it is attached, and it also triggers apoptosis in a significant proportion of the cells to which it binds. The product was first discovered by Coulter Corporation, Miami, in collaboration with the Dana-Farber Cancer Institute and the University of Michigan. The spin-off company Coulter Pharmaceutical, upon its formation, obtained worldwide rights to iodine-131 tositumomab. (Coulter Corporation was acquired subsequently by Beckman Instruments in October 1997. The union of the two companies produced Beckman Coulter.) In December 2000, Coulter Pharmaceutical was acquired by, and merged into, Corixa Corporation.Iodine-131 tositumomab is available for licencing in Japan. Corixa Corporation and GlaxoSmithKline signed an agreement to jointly develop and commercialise iodine-131 tositumomab. The total agreement has a potential value of up to $US132 million, plus shared profits and royalties. The two companies will jointly market the antibody in the US following regulatory approval. Corixa Corporation has announced it expects iodine-131 tositumomab to be approved in the US for non-Hodgkin's lymphoma (NHL). Under the terms of the original agreement, GlaxoSmithKline will receive exclusive marketing rights outside the US, excluding Japan. However, an amended agreement between the two companies will allow Corixa Corporation to also market the product outside the US. In February 2003, the European Commission granted iodine-131 tositumomab orphan-drug designation. Corixa Corporation and GlaxoSmithKline also intend to jointly investigate the use of the product in other indications. GlaxoSmithKline may also receive access to second generation anti

  4. Freqüência de hemolisinas anti-A e anti-B em doadores de sangue de Itapeva e Ourinhos

    OpenAIRE

    Fernandes, Vanessa C; Borgatto,Adriano F.; Barberato Filho,Silvio; Toledo, Maria Inês; Lopes, Luciane C

    2008-01-01

    Uma transfusão de sangue com o tipo ABO incorreto pode resultar na morte do paciente, com reação hemolítica intravascular, seguida de alterações imunológicas e bioquímicas. Considerando a pequena quantidade de estudos sobre as hemolisinas anti-A e anti-B e a importância desses anticorpos na prática transfusional, o objetivo deste trabalho foi verificar a frequência dessas hemolisinas e a associação a fatores como etnia e gênero em doadores de sangue dos bancos de sangue dos municípios de Itap...

  5. Navigating Bioethical Waters: Two Pilot Projects in Problem-Based Learning for Future Bioscience and Biotechnology Professionals.

    Science.gov (United States)

    Berry, Roberta M; Levine, Aaron D; Kirkman, Robert; Blake, Laura Palucki; Drake, Matthew

    2016-12-01

    We believe that the professional responsibility of bioscience and biotechnology professionals includes a social responsibility to contribute to the resolution of ethically fraught policy problems generated by their work. It follows that educators have a professional responsibility to prepare future professionals to discharge this responsibility. This essay discusses two pilot projects in ethics pedagogy focused on particularly challenging policy problems, which we call "fractious problems". The projects aimed to advance future professionals' acquisition of "fractious problem navigational" skills, a set of skills designed to enable broad and deep understanding of fractious problems and the design of good policy resolutions for them. A secondary objective was to enhance future professionals' motivation to apply these skills to help their communities resolve these problems. The projects employed "problem based learning" courses to advance these learning objectives. A new assessment instrument, "Skills for Science/Engineering Ethics Test" (SkillSET), was designed and administered to measure the success of the courses in doing so. This essay first discusses the rationale for the pilot projects, and then describes the design of the pilot courses and presents the results of our assessment using SkillSET in the first pilot project and the revised SkillSET 2.0 in the second pilot project. The essay concludes with discussion of observations and results.

  6. T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma.

    Science.gov (United States)

    Ali, Syed Abbas; Shi, Victoria; Maric, Irina; Wang, Michael; Stroncek, David F; Rose, Jeremy J; Brudno, Jennifer N; Stetler-Stevenson, Maryalice; Feldman, Steven A; Hansen, Brenna G; Fellowes, Vicki S; Hakim, Frances T; Gress, Ronald E; Kochenderfer, James N

    2016-09-29

    Therapies with novel mechanisms of action are needed for multiple myeloma (MM). B-cell maturation antigen (BCMA) is expressed in most cases of MM. We conducted the first-in-humans clinical trial of chimeric antigen receptor (CAR) T cells targeting BCMA. T cells expressing the CAR used in this work (CAR-BCMA) specifically recognized BCMA-expressing cells. Twelve patients received CAR-BCMA T cells in this dose-escalation trial. Among the 6 patients treated on the lowest 2 dose levels, limited antimyeloma activity and mild toxicity occurred. On the third dose level, 1 patient obtained a very good partial remission. Two patients were treated on the fourth dose level of 9 × 10(6) CAR(+) T cells/kg body weight. Before treatment, the first patient on the fourth dose level had chemotherapy-resistant MM, making up 90% of bone marrow cells. After treatment, bone marrow plasma cells became undetectable by flow cytometry, and the patient's MM entered a stringent complete remission that lasted for 17 weeks before relapse. The second patient on the fourth dose level had chemotherapy-resistant MM making up 80% of bone marrow cells before treatment. Twenty-eight weeks after this patient received CAR-BCMA T cells, bone marrow plasma cells were undetectable by flow cytometry, and the serum monoclonal protein had decreased by >95%. This patient is in an ongoing very good partial remission. Both patients treated on the fourth dose level had toxicity consistent with cytokine-release syndrome including fever, hypotension, and dyspnea. Both patients had prolonged cytopenias. Our findings demonstrate antimyeloma activity of CAR-BCMA T cells. This trial was registered to www.clinicaltrials.gov as #NCT02215967.

  7. Factorization and non-local 1/m{sub b} corrections in the decay anti B {yields} X{sub s}{gamma}

    Energy Technology Data Exchange (ETDEWEB)

    Benzke, Michael

    2011-06-10

    In this thesis, a systematic analysis of the anti B {yields} X{sub s}{gamma} photon spectrum in the endpoint region is presented. The endpoint region refers to a kinematic configuration of the final state, in which the photon has a large energy m{sub b}-2E{sub {gamma}}=O({lambda}{sub QCD}), while the jet has a large energy but small invariant mass. Using methods of soft-collinear effective theory and heavy-quark effective theory, it is shown that the spectrum can be factorized into hard, jet, and soft functions, each encoding the dynamics at a certain scale. The relevant scales in the endpoint region are the heavy-quark mass m{sub b}, the hadronic energy scale {lambda}{sub QCD} and an intermediate scale {radical}({lambda}{sub QCD}m{sub b}) associated with the invariant mass of the jet. It is found that the factorization formula contains two different types of contributions, distinguishable by the space-time structure of the underlying diagrams. On the one hand, there are the direct photon contributions which correspond to diagrams with the photon emitted directly from the weak vertex. The resolved photon contributions on the other hand arise at O(1/m{sub b}) whenever the photon couples to light partons. In this work, these contributions are explicitly defined in terms of convolutions of jet functions with subleading shape functions. While the direct photon contributions can be expressed in terms of a local operator product expansion, when the photon spectrum is integrated over a range larger than the endpoint region, the resolved photon contributions always remain non-local. Thus, they are responsible for a non-perturbative uncertainty on the partonic predictions. In this thesis, the effect of these uncertainties is estimated in two different phenomenological contexts. First, the hadronic uncertainties in the anti B {yields} X{sub s}{gamma} branching fraction, defined with a cut E{sub {gamma}} > 1.6GeV are discussed. It is found, that the resolved photon

  8. Discriminating between SUSY and non-SUSY Higgs sectors through the ratio H → b anti b/H → τ{sup +}τ{sup -}

    Energy Technology Data Exchange (ETDEWEB)

    Arganda, E.; Penaranda, S. [Universidad de Zaragoza, Departamento de Fisica Teorica, Facultad de Ciencias, Zaragoza (Spain); Guasch, J. [Universitat de Barcelona, Departament de Fisica Fonamental, Barcelona, Catalonia (Spain); Universitat de Barcelona, Institut de Ciencies del Cosmos (ICC), Barcelona, Catalonia (Spain); Hollik, W. [Max-Planck-Institut fuer Physik, Muenchen (Germany)

    2016-05-15

    It is still an open question whether the new scalar particle discovered at the LHC with a mass of 125 GeV is the SM Higgs boson or belongs to models of new physics with an extended Higgs sector, as the MSSM or 2HDM. The ratio of branching fractions R = BR(H → b anti b)/BR(H → τ{sup +}τ{sup -}) of Higgs-boson decays is a powerful tool in distinguishing the MSSM Higgs sector from the SM or non-supersymmetric 2HDM. This ratio receives large renormalization-scheme independent radiative corrections in supersymmetric models at large tan β, which are insensitive to the SUSY mass scale and absent in the SM or 2HDM. Making use of the current LHC data and the upcoming new results on Higgs couplings to be reported by ATLAS and CMS collaborations and in a future linear collider, we develop a detailed and updated study of this ratio R which improves previous analyses and sets the level of accuracy needed to discriminate between models. (orig.)

  9. Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements.

    Science.gov (United States)

    McRae, Michael P; Simmons, Glennon W; Wong, Jorge; Shadfan, Basil; Gopalkrishnan, Sanjiv; Christodoulides, Nicolaos; McDevitt, John T

    2015-10-21

    The development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system.

  10. 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.

    Science.gov (United States)

    Nelson, Christopher J; Ausió, Juan

    2012-06-01

    The 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability in Whistler, Canada, 14-18 March 2012, brought together 31 speakers from different nationalities. The organizing committee, led by Jim Davie (Chair) at the University of Manitoba (Manitoba, Canada), consisted of several established researchers in the fields of chromatin and epigenetics from across Canada. The meeting was centered on the contribution of epigenetics to gene expression, DNA damage and repair, and the role of environmental factors. A few interesting talks on replication added some insightful information on the controversial issue of histone post-translational modifications as genuine epigenetic marks that are inherited through cell division.

  11. Tutorials in mathematical biosciences

    CERN Document Server

    2008-01-01

    The book offers an easy introduction to fast growing research areas in evolution of species, population genetics, ecological models, and population dynamics. The first two chapters review the concept and methodologies of phylogenetic trees; computational schemes and illustrations are given, including applications such as tracing the origin of SARS and influenza. The third chapter introduces the reader to ecological models, including predator-prey models. This chapter includes and introduction to reaction-diffusion equations, which are used to analyze the ecological models. The next chapter reviews a broad range of ongoing research in population dynamics, including evolution of dispersal models; it also features interesting mathematical theorems and lists open problems. The final chapter deals with gene frequencies under the action of migration and selection. The book is addressed to readers at the level of grad students and researchers. A background in PDEs is provided.

  12. Ranolazine (Roche Bioscience).

    Science.gov (United States)

    Jones, R

    1999-12-01

    Ranolazine is a metabolic modulator that is being developed by CV Therapeutics (CVT), under license from Roche (formerly Syntex), as a potential treatment for angina. In August 1999, the first of two pivotal phase III clinical trials in patients with stable angina was completed. In August 1999, CVT announced initial results from this trial, designated the MARISA trial, of ranolazine in patients with stable angina. At each of the three doses studied, ranolazine significantly increased patients' treadmill exercise duration compared to placebo, the primary endpoint for this trial. MARISA (monotherapy assessment of ranolazine in stable angina) was a randomized, double-blind, placebo-controlled trial of a sustained release formulation of ranolazine used in 175 patients who were not receiving other anti-anginal drugs. Compared to placebo, ranolazine taken bid at doses of 500, 1000 or 1500 mg significantly increased exercise duration at trough plasma concentrations, which occur at about 12 h after the previous dose. In addition, two key secondary endpoints, exercise time to onset of angina and exercise time to the electrocardiographic appearance of ischemia were also significantly increased by ranolazine compared to placebo at all three doses. The company plans on presenting additional data at a major medical conference, including safety and tolerability data, which are still under analysis. In July 1999 CVT initiated its second phase III trial. The CARISA trial (combination assessment of ranolazine in stable angina) is a randomized, double-blind, placebo-controlled trial of ranolazine used in combination with other anti-anginal drugs, in approximately 450 patients. The primary endpoint for this trial, duration of exercise on a treadmill, is identical to that used in phase II clinical trials. The CARISA trial, along with the pivotal phase III MARISA trial which completed treatment in June 1999, is expected to form the basis of the company's NDA submission to the FDA. In June 1999, results of a randomized, double-blind, placebo-controlled phase II study of ranolazine in chronic stable angina pectoris were published in the July 1, 1999 issue of the American Journal of Cardiology. The study of 312 patients demonstrated that ranolazine may increase exercise time in chronic stable angina patients. The results also indicate that there may be no change in heart rate or blood pressure among any of the ranolazine dosing regimens. In January 1999, CVT received regulatory clearance in Canada, the Czech Republic and Poland and initiated its first pivotal phase III trial for ranolazine in these countries. These new clinical trial centers complement the US centers enrolling American patients. The compound allows maintenance of energy output by muscle cells by improving oxygen metabolism to make the heart pump more efficiently. Ranolazine may be especially useful in angina patients in whom other therapies are ineffective. Clinical studies suggest that ranolazine lowers the heart's demand for oxygen, by increasing its ability to use carbohydrate rather than fat as a fuel. This is thought to be due to activation of pyruvate dehydrogenase, and also by modulating the activities of L-type calcium channels. This is achieved without reducing heart rate or blood pressure, or impairing pumping ability. In August 1998, CVT signed an agreement with Catalytica Pharmaceuticals, which will manufacture specified quantities of ranolazine for use in clinical trials.

  13. Development of a dedicated beam forming system for material and bioscience research with high intensity, small field electron beam of LILLYPUT 3 accelerator at Wroclaw Technology Park

    CERN Document Server

    Adrich, Przemysław; Wilk, Piotr; Chorowski, Maciej; Poliński, Jarosław; Bogdan, Piotr

    2016-01-01

    The primary use of the LILLYPUT 3 accelerator at the Nondestructive Testing Laboratory at Wroclaw Technology Park is X-ray radiography for nondestructive testing, including R&D of novel techniques for industrial and medical imaging. The scope of possible applications could be greatly extended by providing a system for irradiation with electron beam. The purpose of this work was to design such a system, especially for high dose rate, small field irradiations under cryogenic conditions for material and bioscience research. In this work, two possible solutions, based either on beam scanning or scattering and collimation, were studied and compared. It was found that under existing conditions efficiency of both systems would be comparable. The latter one was adopted due to its simplicity and much lower cost. The system design was optimized by means of detailed Monte Carlo modeling. The system is being currently fabricated at National Centre for Nuclear Research in \\'Swierk.

  14. The integration of the "spirituality in medicine" curriculum into the osteopathic communication curriculum at Kansas City University of Medicine and Biosciences.

    Science.gov (United States)

    Talley, Jan A; Magie, Richard

    2014-01-01

    With grant funding from the John Templeton Spirituality and Medicine Curricular Award to the George Washington Institute for Spirituality and Health, faculty at Kansas City University of Medicine and Biosciences (KCUMB) developed the "Spirituality in Medicine" curriculum. In developing the curriculum, faculty took into consideration competencies required by the Association of American Medical Colleges and qualitative results from surveys of medical school applicants and enrolled students. Strategies for curriculum delivery included lectures, panel discussions, role-playing, and training in the use of a spirituality assessment tool. A majority of the 250 students who received the training in 2010-2011 were able to demonstrate the following competencies: (1) being sensitive to patients' spiritual and cultural needs, (2) assessing patients' and their own spiritual needs, (3) appropriately using chaplain services for patient care, and (4) understanding the effects of health disparities and ethical issues on patient care. Challenges to implementation included a reduction in chaplain availability due to the economic downturn, a lack of student exposure to direct patient care during shadowing, too little religious diversity among chaplains, and changes in assignment schedules. New competencies required by the National Board of Osteopathic Medical Examiners overlap with and help ensure sustainability of the Spirituality in Medicine curriculum. KCUMB leaders have incorporated the use of the spirituality assessment tool into other parts of the curriculum and into service experiences, and they have introduced a new elective in palliative care. Synergistic efforts by faculty leaders for this initiative were critical to the implementation of this curriculum.

  15. Current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States). Systems Surety Assessment Dept.; Noren, K. [Univ. of Idaho, Moscow, ID (United States). Dept. of Electrical Engineering

    1996-09-01

    The current that flows between the electrical test equipment and the nuclear explosive must be limited to safe levels during electrical tests conducted on nuclear explosives at the DOE Pantex facility. The safest way to limit the current is to use batteries that can provide only acceptably low current into a short circuit; unfortunately this is not always possible. When it is not possible, current limiters, along with other design features, are used to limit the current. Three types of current limiters, the fuse blower, the resistor limiter, and the MOSFET-pass-transistor limiters, are used extensively in Pantex test equipment. Detailed failure mode and effects analyses were conducted on these limiters. Two other types of limiters were also analyzed. It was found that there is no best type of limiter that should be used in all applications. The fuse blower has advantages when many circuits must be monitored, a low insertion voltage drop is important, and size and weight must be kept low. However, this limiter has many failure modes that can lead to the loss of over current protection. The resistor limiter is simple and inexpensive, but is normally usable only on circuits for which the nominal current is less than a few tens of milliamperes. The MOSFET limiter can be used on high current circuits, but it has a number of single point failure modes that can lead to a loss of protective action. Because bad component placement or poor wire routing can defeat any limiter, placement and routing must be designed carefully and documented thoroughly.

  16. Teaching and learning in the Biosciences: the development of an educational programme to assist student nurses in their assessment and management of patients with wounds.

    Science.gov (United States)

    Redmond, Catherine; Davies, Carmel; Cornally, Deirdre; Fegan, Marianne; O'Toole, Margaret

    2016-09-01

    The aim of this project was to develop an educational package for undergraduate student nurses that would provide them with the theoretical knowledge and clinical judgement skills to care for a patient with a wound. Internationally there is concern over the adequacy of preparation of undergraduate nurses for the clinical skill of wound care. Deficits have also been identified in the underpinning biological sciences needed for this skill. Expectations associated with wound management have altered significantly in the last two decades with decision making around wound care coming under the scope of practice of nurses. The treatment and care options for patients with wounds must be based on a sound knowledge of how wounds are formed and healed. If nurses do not have the evidence-based knowledge, it can affect wound healing adversely leading to increased patient suffering, pain and delayed healing. From an organisational perspective, delayed healing will increase the cost of care. This project used constructivism learning theory to provide a framework for the development of a wound care educational package for undergraduate Irish nurses in their penultimate year of training. Collaboration was formed with key stake holders. Pertinent curriculum content was mapped. Learning strategies to suit the incoming student learning styles were incorporated into newly developed theoretical content and practical skill sessions. The developed educational programme will assist student nurses in their care of patients with wounds. This study provides a model that can be followed to develop small units of the study to keep abreast of changes in health care delivery and the changing scope of practice of nurses. It also contributes to the debate on the teaching and learning of biosciences as it highlights the depth of biological knowledge required as a basis for good evidence-based nursing care. © 2015 John Wiley & Sons Ltd.

  17. Limited Neutrality

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul

    2006-01-01

    Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."......Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."...

  18. Limiting Skepticism

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella; Symons, John

    2011-01-01

    Skeptics argue that the acquisition of knowledge is impossible given the standing possibility of error. We present the limiting convergence strategy for responding to skepticism and discuss the relationship between conceivable error and an agent’s knowledge in the limit. We argue that the skeptic...

  19. Limited Neutrality

    DEFF Research Database (Denmark)

    Nielsen, Morten Ebbe Juul

    2006-01-01

    Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."......Article Concerning the prospect of a kind of limited neutrality in place of the standard liberal egalitarian "neutrality of justification."...

  20. A novel flavour tagging algorithm using machine learning techniques and a precision measurement of the B{sup 0}- anti B{sup 0} oscillation frequency at the LHCb experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kreplin, Katharina

    2015-06-10

    This thesis presents a novel flavour tagging algorithm using machine learning techniques and a precision measurement of the B{sup 0}- anti B{sup 0} oscillation frequency Δm{sub d} using semileptonic B{sup 0} decays. The LHC Run I data set is used which corresponds to 3 fb{sup -1} of data taken by the LHCb experiment at a center-of-mass energy of 7 TeV and 8 TeV. The performance of flavour tagging algorithms, exploiting the b anti b pair production and the b quark hadronization, is relatively low at the LHC due to the large amount of soft QCD background in inelastic proton-proton collisions. The standard approach is a cut-based selection of particles, whose charges are correlated to the production flavour of the B meson. The novel tagging algorithm classifies the particles using an artificial neural network (ANN). It assigns higher weights to particles, which are likely to be correlated to the b flavour. A second ANN combines the particles with the highest weights to derive the tagging decision. An increase of the opposite side kaon tagging performance of 50% and 30% is achieved on B{sup +} → J/ψK{sup +} data. The second number corresponds to a readjustment of the algorithm to the B{sup 0}{sub s} production topology. This algorithm is employed in the precision measurement of Δm{sub d}. A data set of 3.2 x 10{sup 6} semileptonic B{sup 0} decays is analysed, where the B{sup 0} decays into a D{sup -}(K{sup +}π{sup -}π{sup -}) or D{sup *-} (π{sup -} anti D{sup 0}(K{sup +} π{sup -})) and a μ{sup +}ν{sub μ} pair. The ν{sub μ} is not reconstructed, therefore, the B{sup 0} momentum needs to be statistically corrected for the missing momentum of the neutrino to compute the correct B{sup 0} decay time. A result of Δm{sub d}=0.503±0.002(stat.)±0.001(syst.) ps{sup -1} is obtained. This is the world's best measurement of this quantity.

  1. Inverse Limits

    CERN Document Server

    Ingram, WT

    2012-01-01

    Inverse limits provide a powerful tool for constructing complicated spaces from simple ones. They also turn the study of a dynamical system consisting of a space and a self-map into a study of a (likely more complicated) space and a self-homeomorphism. In four chapters along with an appendix containing background material the authors develop the theory of inverse limits. The book begins with an introduction through inverse limits on [0,1] before moving to a general treatment of the subject. Special topics in continuum theory complete the book. Although it is not a book on dynamics, the influen

  2. Measurement of the Branching Fractions of Exclusive anti-B -> D/D*/D(*) pi l- anti-nu_l Decays in Events Tagged by a Fully Reconstructed B Meson

    CERN Document Server

    Aubert, B; Boutigny, D; Karyotakis, Yu; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Graugès-Pous, E; Lopez, Spain L; Palano, A; Pappagallo, M; Eigen, Italy`G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lopes-Pegna, D; Lynch, G; Mir, L M; Orimoto, T J; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabé, T; Wenzel, W A; Del Amo-Sánchez, P; Hawkes, C M; Watson, A T; Koch, H; Schröder, T; Walker, D; Asgeirsson, D J; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Kovalskyi, D; Richman, J D; Beck, USAT W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Lombardo, V; Thiebaux, C; Verderi, M; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Robertson, A I; Watson, J E; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, Italy A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Flack, R L; Nash, J A; Panduro-Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Bequilleux, J; D'Orazio, A; Davier, M; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, e A M; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, L; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Flächer, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Allison, USAJ; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; Zheng, Y; Mclachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Palombo, F; Bauer, Italy J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaudoe, F B; Nicholson, H; De Nardo, Gallieno; Fabozzi, F; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; De La Vaissière, C; Hamon, O; Leruste, P; Malcles, J; Ocariz, J; Pérez, A; Prendkie, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; CAngelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cenci, R; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M; Morganti, M; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Bellini, F; Cavoto, G; Del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Castelli, G; Franek, B; Olaiya, E; Röthel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yeche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle,; Claus, P; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Pulliam, T; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; chwiening, J; Snyder, A; Su, D; Sun, S; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Krishnamurthy, M; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gallo, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini,; Lopez-March, N; Martínez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Wu, S L; Neal, H

    2007-01-01

    We present a measurement of the branching fractions for anti-B -> D/D*/D(*) pi l^- anti-nu_l decays based on 341.1 fb-1 of data collected at the Upsilon(4S) resonance with the BaBar detector at the pep-II e^+e^- storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We obtain BF (B^- -> D^0 l^- anti-nu_l) = (2.33 +/- 0.09(stat.) +/- 0.09(syst.))%, BF (B^- -> D^*0 l^- anti-nu_l) = (5.83 +/- 0.15(stat.) +/- 0.30(syst.))%, BF (B0bar -> D^+ l^- anti-nu_l) = (2.21 +/- 0.11(stat.) +/- 0.12(syst.))%, BF (B0bar -> D^*+ l^- anti-nu_l) = (5.49 +/- 0.16(stat.) +/- 0.25(syst.))%, BF (B^- -> D^+ pi^- l^- anti-nu_l) = (0.42 +/- 0.06(stat.) +/- 0.03(syst.))%, BF (B^- -> D^*+ pi^- l^- anti-nu_l) = (0.59 +/- 0.05(stat.) +/- 0.04(syst.))%, BF (B0bar -> D^0 pi^+ l^- anti-nu_l) = (0.43 +/- 0.08(stat.) +/- 0.03(syst.))% and BF (B0bar -> D^*0 pi^+ l^- anti-nu_l) = (0.48 +/- 0.08(stat.) +/- 0.04(syst.))%.

  3. Multicenter Evaluation of Meridian Bioscience HSV 1&2 Molecular Assay for Detection of Herpes Simplex Virus 1 and 2 from Clinical Cutaneous and Mucocutaneous Specimens.

    Science.gov (United States)

    Faron, Matthew L; Ledeboer, Nathan A; Patel, Anami; Beqa, Safedin H; Yen-Lieberman, Belinda; Kohn, Debra; Leber, Amy L; Mayne, Donna; Northern, William I; Buchan, Blake W

    2016-08-01

    Herpes simplex virus (HSV) causes acute and relapsing symptoms characterized by ulcerative lesions. Laboratory diagnosis of HSV in cutaneous or mucocutaneous lesions has historically been performed with the use of viral cell culture systems; however, these tests are laborious and suffer decreased sensitivity for advanced-stage lesions. The recent availability of FDA-cleared moderately complex assays has resulted in the increased use of molecular diagnostics for the routine detection of HSV in superficial swab specimens. We performed a clinical evaluation of the recently FDA-cleared illumigene HSV 1&2 loop-mediated isothermal amplification (LAMP) assay (Meridian Bioscience, Cincinnati OH) for the detection and differentiation of HSV-1 and HSV-2 in cutaneous and mucocutaneous swab specimens. A total of 1,153 clinical swab specimens were collected and tested at 7 different clinical centers. Each specimen was tested for the presence of HSV-1 and HSV-2 using the illumigene assay, and results were compared to those of the enzyme-linked virus-inducible system (ELVIS) as the reference method. Overall, the illumigene assay demonstrated a sensitivity and specificity of 94.8% and 95.5%, respectively, for the detection of HSV-1. Detection of HSV-2 was similar, with a sensitivity of 98.9% and a specificity of 95.5%. Discrepant analysis was performed using an alternative molecular test (AmpliVue HSV1+2 assay; Quidel Molecular, San Diego, CA) on 91/99 specimens that were recorded as false positive (FP) or false negative (FN) compared to the reference method. In total, 57/78 (73%) FP and 9/13 (69%) FN illumigene results were supported by the AmpliVue result. The illumigene HSV 1&2 assay demonstrated high sensitivity and specificity to detect and differentiate HSV in clinical specimens and identified 57 additional specimens that were positive for HSV compared to culture. The use of LAMP eliminates the need for the cycling of temperatures and provides results in less than 60 min

  4. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2008-03-01

    Full Text Available mandate of contributing to improved quality of life and industrial competitiveness through research, development and innovation and in response to the National Research and Development Strategy and National Biotechnology Strategy....

  5. CSIR eNews: Biosciences

    CSIR Research Space (South Africa)

    CSIR

    2008-12-01

    Full Text Available the potential South African medicinal plants hold for the treatment of various diseases. Maharaj said they would focus on plant-based leads for anti-cancer drugs and treatment of Alzheimers disease while several local researchers would visit Korea from March...

  6. The interfacial bioscience grand challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Pamela; Stevens, Mark Jackson; Jacobsen, Richard B.; Hong, Joohee; Ayson, Marites J.; Crozier, Paul Stewart; Wood, Nichole L.; Schoeniger, Joseph S.; Kruppa, Gary Hermann; Sale, Kenneth L.; Young, Malin M.; Faulon, Jean-Loup Michel; Burns, Alan Richard; Evans, Kervin O.; Novak, Petr

    2004-03-01

    This report is broken down into the following 3 sections: (1) Chemical Cross-linking and Mass Spectrometry Applied to Determination of Protein Structure and Dynamics; (2) Computational Modeling of Membrane Protein Structure and Dynamics; and (3) Studies of Toxin-Membrane Interactions using Single Molecule Biophysical Methods.

  7. Limits on $\

    CERN Document Server

    Perego, D L

    2002-01-01

    A limit on the tau neutrino mass is obtained using all the $Z^{0} \\to \\tau^{+} \\tau^{-}$ data collected at LEP by the DELPHI detector between 1992 and 1995. In this analysis events in which one of the taus decays into one charged particle, while the second $\\tau$ decays into f{}ive charged pions (1-5 topology) have been used. The neutrino mass is determined from a bidimensional \\fit ~on the invariant mass $m^{*}_{5 \\pi}$ and on the energy $E_{5 \\pi}$ of the f{}ive $\\pi^{\\pm}$ system. The result found is $m_{\

  8. Lower limits for parallel impurity fluxes in the PLT edge plasma

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, S.A.; Dylla, H.F.

    1978-05-01

    Lower limits for time-resolved anti B-parallel impurity fluxes to solid collectors immersed in the PLT edge plasma have been determined as a function of minor radius. Using geometric shadowing of the probe surface, features attributed to finite ion gyroradii have been observed. Also, for r less than 48 cm, heat pulses of less than 2 ms duration and greater than 2.5 x 10/sup 3/ W/cm/sup 2/ intensity were found to occur at the termination of many discharges.

  9. Age Limits.

    Science.gov (United States)

    Antfolk, Jan

    2017-03-01

    Whereas women of all ages prefer slightly older sexual partners, men-regardless of their age-have a preference for women in their 20s. Earlier research has suggested that this difference between the sexes' age preferences is resolved according to women's preferences. This research has not, however, sufficiently considered that the age range of considered partners might change over the life span. Here we investigated the age limits (youngest and oldest) of considered and actual sex partners in a population-based sample of 2,655 adults (aged 18-50 years). Over the investigated age span, women reported a narrower age range than men and women tended to prefer slightly older men. We also show that men's age range widens as they get older: While they continue to consider sex with young women, men also consider sex with women their own age or older. Contrary to earlier suggestions, men's sexual activity thus reflects also their own age range, although their potential interest in younger women is not likely converted into sexual activity. Compared to homosexual men, bisexual and heterosexual men were more unlikely to convert young preferences into actual behavior, supporting female-choice theory.

  10. Bx亚型伴抗-B抗体产生的血型血清学特性分析与输血策略%The Characteristic of Blood Group Serologic and Blood Transfusion Strategy about Bx Subtypes with Anti-B

    Institute of Scientific and Technical Information of China (English)

    王霞; 王湘屏; 徐新

    2014-01-01

    Objective The study was desingned to analyze the characteristic of blood group serologic produced by Bx subtypes with anti-B,and explore the therapeutic schedule by blood transfusion. Methods Samples of ABO blood group with identification of positive and negative stereotypes discrepancy were analyzed by blood type serological analysis such as absorb-radiation test,blood type material of saliva agglutination inhibition test. The patients accord with the charac-teristic of blood group serologic produced by Bx subtypes with anti-B were comparatively studied with blood transfusion treatment,and the curative effect of blood transfusion was observed. Results The results of serological test suggested that the patients with blood type Bx subtypes and anti-B did not get a blood transfusion adverse reactions and has a good effect, when they received a blood transfusion therapy with O red blood cells,type AB blood platelets and plasma. Conclusion Because B antigen expression decreased,serological characteristics of Bx subtypes with anti-B are inconsistent. The reaction with anti-AB agglutination can be enhanced or not react with the positive and negative blood type identification. The intensi-ty of H antigen expression is similar to the O cells,while producing low reactivity of anti-B. The secreting type spittle can only have H,lack of B. The infusion treatment with assorted blood instead is safe and effective when the Bx subtypes with anti-B patients is in urgent circumstances and the same type of blood cannot be found.%目的:分析Bx亚型伴抗-B抗体产生的血型血清学特性,并探讨其输血治疗方案。方法对ABO血型鉴定正反定型不符的样本进行吸收-放散试验、唾液血型物质凝集-抑制试验等血型血清学分析。对符合Bx亚型伴抗-B抗体产生血型血清学特性的患者,采取配合性血液输注,并观察输血疗效。结果血型血清学试验结果提示患者为Bx亚型伴抗-B产生,给予O型红细胞

  11. Efeito da talidomida sobre os níveis séricos de imunoglobulinas IgM e IgA, fator reumatóide e isohemaglutinina anti-A e anti-B em pacientes com lepra lepromatosa: um estudo duplo-cego

    Directory of Open Access Journals (Sweden)

    Walter Oleschko Arruda

    1986-02-01

    Full Text Available Um estudo duplo-cego foi conduzido em pacientes portadores de lepra lepromatosa estável, para avaliar a resposta à administração de talidomida 100 mg por dia, por 18 dias, dos níveis séricos de IgM e IgA e dos títulos de fator reumatóide e isohemaglutininas anti-A e anti-B. Nenhum efeito significativo foi detectado ao fim deste período.

  12. Bioética, violência e desigualdade: as biociências e a constituição do biopoder Bioethics, violence and inequality: the biosciences and the conquest of biopower

    Directory of Open Access Journals (Sweden)

    Hélder Boska de Moraes Sarmento

    2008-12-01

    Full Text Available A sociedade contemporânea está atravessada por contradições e paradoxos, dentre os quais vale destacar a relação entre a alta tecnologia e, a pior situação humana, a miséria. Resultado das escolhas éticas e políticas desta era tecnológica, vive-se em situações de fronteira, nas quais as biociências desempenham papel central, tanto no volume de conhecimentos gerados, como na utilização de seus resultados, que, sem controle social, ampliam desigualdades. O objetivo deste artigo é demonstrar o quanto as biociências articulam-se com o desenvolvimento científico dos países inovadores de tecnologia, criando uma nova relação de poder, violento e desigual para os que apenas a consomem, denominado de biopoder. Daí a necessidade de uma bioética crítica capaz de empreender reflexões sobre os procedimentos técnicos, os fundamentos da atividade científica, sua aplicabilidade e relação com o mercado, oportunizando uma 'ponte' na tomada de decisões para que a própria ciência não se torne um obstáculo à democracia.Contemporary society is rife with contradictions and paradoxes, among which stand out the relationship between high technology and the worst human situation, poverty. The result of ethical and political choices of this technological era, we experience frontier situations, in which the biosciences play a central role, both in the volume of knowledge generated, as well as in the use of their results which, without social control, broaden inequalities. The objective of this article is to demonstrate the degree to which the biosciences are articulated with the scientific development of the countries that innovate technologies, creating a new relationship of power, which is violent and unequal for those who only consume, denominated biopower. This creates a need for a critical bioethics that is capable of reflecting on the technical procedures, the bases of scientific activity and their applicability and relation with

  13. The nature of Z{sub b} states from a combined analysis of Υ(5S) → h{sub b}(mP)π{sup +}π{sup -} and Υ(5S) → B{sup (*)} anti B{sup (*)}π

    Energy Technology Data Exchange (ETDEWEB)

    Huo, Wen-Sheng [Xinjiang University, Department of Physics, Ueruemqi (China); Chen, Guo-Ying [Xinjiang University, Department of Physics, Ueruemqi (China); Institute of Theoretical Physics, Chinese Academy of Sciences, State Key Laboratory of Theoretical Physics, Beijing (China)

    2016-03-15

    With a combined analysis of data on Υ(5S) → h{sub b}(1P, 2P)π{sup +}π{sup -} and Υ(5S) → B{sup (*)} anti B{sup (*)}π in an effective field theory approach, we determine resonance parameters of Z{sub b} states in two scenarios. In one scenario we assume that Z{sub b} states are pure molecular states, while in the other one we assume that Z{sub b} states contain compact components. We find that the present data favor that there should be some compact components inside Z{sub b}{sup (')} associated with themolecular components. By fitting the invariant mass spectra of Υ(5S) → h{sub b}(1P, 2P)π{sup +}π{sup -} and Υ(5S) → B{sup (*)} anti B{sup *}π, we determine that the probability of finding the compact components in Z{sub b} states may be as large as about 40 %. (orig.)

  14. Search for a Higgs Boson in W H --> l nu b anti-b in p anti-p Collisions at s**(1/2) = 1.96 TeV

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, Jahred A.; /Chicago U., EFI; Akimoto, T.; /Tsukuba U.; Alvarez Gonzalez, B.; /Cantabria Inst. of Phys.; Amerio, S.; /INFN, Padua; Amidei, Dante E.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, Alberto; /Frascati; Antos, Jaroslav; /Comenius U.; Apollinari, G.; /Fermilab; Apresyan, A.; /Purdue U. /Waseda U.

    2009-06-01

    We present a search for a standard model Higgs boson produced in association with a W boson using 2.7 fb{sup -1} of integrated luminosity of p{bar p} collision data taken at {radical}s = 1.96 TeV. Limits on the Higgs boson production rate are obtained for masses between 100 GeV/c{sup 2} and 150 GeV/c{sup 2}. Through the use of multivariate techniques, the analysis achieves an observed (expected) 95% confidence level upper limit of 5.6 (4.8) times the theoretically expected production cross section for a standard model Higgs boson with a mass of 115 GeV/c{sup 2}.

  15. Search for the Production of Narrow t anti-b Resonances in 1.9 fb-1 of p anti-p Collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Aaltonen, T.; /Helsinki Inst. of Phys.; Adelman, J.; /Chicago U., EFI; Akimoto, T.; /Tsukuba U.; Alvarez Gonzalez, B.; /CSIC, Catalunya; Amerio, S.; /INFN, Padua; Amidei, Dante E.; /Michigan U.; Anastassov, A.; /Northwestern U.; Annovi, Alberto; /Frascati; Antos, Jaroslav; /Comenius U.; Apollinari, G.; /Fermilab; Apresyan, A.; /Purdue U. /Waseda U.

    2009-02-01

    We present new limits on resonant tb production in ppbar collisions at sqrt(s) = 1.96 TeV, using 1.9 fb{sup -1} of data recorded with the CDF II detector at the Fermilab Tevatron. We reconstruct a putative tb mass in events with a lepton, neutrino candidate, and two or three jets, and search for anomalous tb production as modeled by W{prime} {yields} tb. We set a new limit on a right-handed W{prime} with standard model-like coupling, excluding any mass below 800 GeV at 95% C.L. For any narrow W{prime}-like state with mass above 800 GeV, the cross-section is found to be less than 0.28 pb at 95% C.L. We also present an exclusion of the W{prime} coupling strength versus W{prime} mass.

  16. Search for Resonant Pair Production of long-lived particles decaying to b anti-b in p anti-p collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abazov, V.M.; /Dubna, JINR; Abbott, B.; /Oklahoma U.; Abolins, M.; /Michigan State U.; Acharya, B.S.; /Tata Inst.; Adams, M.; /Illinois U., Chicago; Adams, T.; /Florida State U.; Aguilo, E.; /Alberta U. /Simon Fraser U. /York U., Canada /McGill U.; Ahsan, M.; /Kansas State U.; Alexeev, G.D.; /Dubna, JINR; Alkhazov, G.; /St. Petersburg, INP; Alton, A.; /Michigan U. /Northeastern U.

    2009-06-01

    We report on a first search for production of Higgs bosons decaying into neutral long-lived particles (NLLP) which each decay to a b{bar b} pair, using 3.6 fb{sup -1} of data recorded with the D0 detector at the Fermilab Tevatron collider. We search for pairs of displaced vertices in the tracking detector at radii in the range 1.6-20 cm from the beam axis. No significant excess is observed above background, and upper limits are set on the production rate in a hidden-valley benchmark model for a range of Higgs boson masses and NLLP masses and lifetimes.

  17. Search for H ---> b anti-b produced in association with W bosons in p anti-p collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abulencia, A.; Acosta, D.; Adelman, Jahred A.; Affolder, Anthony A.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; /Taiwan,

    2005-12-01

    The authors present a search for the standard model Higgs boson decaying into b{bar b} and produced in association with W bosons in p{bar p} collisions at {radical}s = 1.96 TeV. This search uses 320 pb{sup -1} of the dataset accumulated by the upgraded Collider Detector at Fermilab. Events are selected that have a high-transverse momentum electron or muon, missing transverse energy, and two jets, at least one of which is consistent with the hadronization of a b quark. Both the number of events and the dijet mass distribution are consistent with standard model background expectations, and they set 95% confidence level upper limits on the production cross section times branching ratio for the Higgs boson or any new particle with similar decay kinematics. These upper limits range from 10 pb for m{sub H} = 110 GeV/c{sup 2} to 3 pb for m{sub H} = 150 GeV/c{sup 2}.

  18. Search for H ---> b anti-b produced in association with W bosons in p anti-p collisions at s**(1/2) = 1.96-TeV

    Energy Technology Data Exchange (ETDEWEB)

    Abulencia, A.; Acosta, D.; Adelman, Jahred A.; Affolder, Anthony A.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; /Taiwan,

    2005-12-01

    The authors present a search for the standard model Higgs boson decaying into b{bar b} and produced in association with W bosons in p{bar p} collisions at {radical}s = 1.96 TeV. This search uses 320 pb{sup -1} of the dataset accumulated by the upgraded Collider Detector at Fermilab. Events are selected that have a high-transverse momentum electron or muon, missing transverse energy, and two jets, at least one of which is consistent with the hadronization of a b quark. Both the number of events and the dijet mass distribution are consistent with standard model background expectations, and they set 95% confidence level upper limits on the production cross section times branching ratio for the Higgs boson or any new particle with similar decay kinematics. These upper limits range from 10 pb for m{sub H} = 110 GeV/c{sup 2} to 3 pb for m{sub H} = 150 GeV/c{sup 2}.

  19. HOME Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — HOME Income Limits are calculated using the same methodology that HUD uses for calculating the income limits for the Section 8 program. These limits are based on HUD...

  20. Passive immitance limiters

    OpenAIRE

    Filinyuk N. A.; Lischinskaya L. B.; Chekhmestruk R. Yu.

    2015-01-01

    The paper presents quadripole R, L, C immittance limiters, in which output immittance to the certain value depends on the input immittance. A classification of immittance limiters is given. Basic parameters are considered: low and high levels of output immittance limiters; low and high values of input immittance, corresponding to low and high levels of limitation, accordingly; range of possible values of output immittance; steepness of immittance limiters; time of wearing-out (or delay); high...

  1. 层次递进的生物科学实验教学体系构建%Construction of Hierarchical Progressive Experiment Teaching System of Bioscience Specialty

    Institute of Scientific and Technical Information of China (English)

    谢青; 杨广笑; 肖靓; 刘幸福; 吴元喜

    2012-01-01

    In order to foster innovative spirit and ability of students in bioscience specialty of National Science Talent Training Base and Qiming College, reform in the experimental course system was carried out and a system called fundament plus module was developed. The students' professional experimental courses began from basic skills training, and gradually transit to the professional training, and then extend to the innovation design and research ability training. In accordance with the progressive training model of experimental teaching, students can gradually complete the teaching syllabus of the experimental training and master techniques and methods of life sciences and other related majors. Meanwhile, comprehensive modern education technology was introduced, open type experimental teaching management model and various rules and regulations were improved and perfected, and good teaching result has been obtained during the practice.%为培养出具有创新精神与创新能力的学生,对生物科学专业理科基地班和启明学院生物科学实验班学生的实验课程体系进行了改革。构建"基础+模块"的实践教学体系。学生的专业实验课从基本技能训练开始,逐步过渡到专业综合训练,再延伸到创新设计和研究能力培养的实验项目。按照递进训练的实验教学模式,学生可以逐步完成教学大纲规定的实验训练,掌握生命科学及相关专业研究的技术和方法。并全面引进现代教育技术,完善开放式实验教学的管理模式和各项规章制度,取得了良好的教学效果。

  2. Automatic figure classification in bioscience literature.

    Science.gov (United States)

    Kim, Daehyun; Ramesh, Balaji Polepalli; Yu, Hong

    2011-10-01

    Millions of figures appear in biomedical articles, and it is important to develop an intelligent figure search engine to return relevant figures based on user entries. In this study we report a figure classifier that automatically classifies biomedical figures into five predefined figure types: Gel-image, Image-of-thing, Graph, Model, and Mix. The classifier explored rich image features and integrated them with text features. We performed feature selection and explored different classification models, including a rule-based figure classifier, a supervised machine-learning classifier, and a multi-model classifier, the latter of which integrated the first two classifiers. Our results show that feature selection improved figure classification and the novel image features we explored were the best among image features that we have examined. Our results also show that integrating text and image features achieved better performance than using either of them individually. The best system is a multi-model classifier which combines the rule-based hierarchical classifier and a support vector machine (SVM) based classifier, achieving a 76.7% F1-score for five-type classification. We demonstrated our system at http://figureclassification.askhermes.org/.

  3. Japan Seeks Balance in Global Bioscience Program

    National Research Council Canada - National Science Library

    Jocelyn Kaiser

    1997-01-01

    ... five times its $4 million contribution. "There is a tendency for other governments to see Japan's support as a small return on their trade imbalance with Japan," says Michel Cuenod, secretary-general of the Strasbourg, France-based program. But Japanese officials, he says, "are growing impatient with continuing the program" if the funding issue is n...

  4. VT Limited Access Highways

    Data.gov (United States)

    Vermont Center for Geographic Information — A limited-access road, known by various terms worldwide, including limited-access highway, dual carriageway, expressway, and partial controlled access highway, is a...

  5. Robust test limits

    NARCIS (Netherlands)

    Albers, Willem/Wim; Kallenberg, W.C.M.; Otten, G.D.

    1997-01-01

    Because of inaccuracies of the measurement process inspection of manufactured parts requires test limits which are more strict than the given specification limits. Test limits derived under the assumption of normality for product characteristics turn out to violate the prescribed bound on the

  6. Passive immitance limiters

    Directory of Open Access Journals (Sweden)

    Filinyuk N. A.

    2015-06-01

    Full Text Available The paper presents quadripole R, L, C immittance limiters, in which output immittance to the certain value depends on the input immittance. A classification of immittance limiters is given. Basic parameters are considered: low and high levels of output immittance limiters; low and high values of input immittance, corresponding to low and high levels of limitation, accordingly; range of possible values of output immittance; steepness of immittance limiters; time of wearing-out (or delay; high and low cutoff frequencies; central working frequency; frequency band; relative range of working frequencies; non-linearity coefficient. The authors have designed passive R-, L-, C-limiters with possibility of limitation from above and from below. The influence of the input parasitic immittances on the immittance transfer characteristic is evaluated. In most cases parasite immittance does not influence the considered devices, including R-limiters «from above» with the input quality factor of QR(Linp=0,1…0,2 and L-limiters «from above» with high-quality input circuits with QL(Rinp>2. The analysis also shows that high-qualitiy circuits with QN(RinpN>3 should be used in C-limiters with input parasitic immittances, while at parasitic immittance of the limiting element low-quality circuits with QN(RiN>0,2 should be selected.

  7. Machado com Flaubert e a escrita anti-bêtise

    Directory of Open Access Journals (Sweden)

    Lívia Cristina Gomes

    2011-10-01

    Full Text Available The texts “O imortal”, by Machado de Assis, and “La légende de Saint Julien l’Hospitalier”, by Gustave Flaubert, are studied here taking into consideration the ironic play of their writings which make the cliché’s list a narrative strategy common to both authors.

  8. Limitations to sharing entanglement

    CERN Document Server

    Kim, Jeong San; Sanders, Barry C

    2011-01-01

    We discuss limitations to sharing entanglement known as monogamy of entanglement. Our pedagogical approach commences with simple examples of limited entanglement sharing for pure three-qubit states and progresses to the more general case of mixed-state monogamy relations with multiple qudits.

  9. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  10. Limits to Inclusion

    Science.gov (United States)

    Hansen, Janne Hedegaard

    2012-01-01

    In this article, I will argue that a theoretical identification of the limit to inclusion is needed in the conceptual identification of inclusion. On the one hand, inclusion is formulated as a vision that is, in principle, limitless. On the other hand, there seems to be an agreement that inclusion has a limit in the pedagogical practice. However,…

  11. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...

  12. Numerical Limit Analysis:

    DEFF Research Database (Denmark)

    Damkilde, Lars

    2007-01-01

    Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...... also enabled engineers to solve practical problems within reinforced concrete, steel structures and geotechnics....

  13. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  14. The Hugoniot Elastic Limit Decay Limit

    Science.gov (United States)

    Billingsley, J. P.

    1997-07-01

    The Hugoniot Elastic Limit(HEL) precursor decay in shock loaded solids has been the subject of considerable experimental and theoretical investigation. Comparative evidence is presented to show that the elastic precursor wave particle velocity, UPHEL, for certain materials decays asymptotically with propagation distance to the DeBroglie velocity, V1, level. This is demonstrated for the following materials: iron, aluminum alloy 6061-T6, plexiglas(PMMA), nickel alloy(MAR-M200), and lithium flouride(LiF). The DeBroglie velocity, V1, equals h/2md, where h is Planck's Constant, m is the mass of one atom, and d is the closest distance between atoms. Thus a relationship has been established between a microscopically derived velocity, V1, and a macroscopically observed velocity, UPHEL.

  15. Branching Fraction Limits for B0 Decays to eta' eta, eta' pi0 and eta pi0

    CERN Document Server

    Aubert, B; Boutigny, D; Couderc, F; Karyotakis, Yu; Lees, J P; Poireau, V; Tisserand, V; Zghiche, A; Graugès-Pous, E; Palano, A; Pappagallo, M; Chen, J C; Qi, N D; Rong, G; Wang, P; Zhu, Y S; Eigen, G; Ofte, I; Stugu, B; Abrams, G S; Battaglia, M; Best, D S; Brown, D N; Button-Shafer, J; Cahn, R N; Charles, E; Day, C T; Gill, M S; Gritsan, A V; Groysman, Y; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Mir, L M; Oddone, P J; Orimoto, T J; Pripstein, M; Roe, N A; Ronan, M T; Wenzel, W A; Barrett, M; Ford, K E; Harrison, T J; Hart, A J; Hawkes, C M; Morgan, S E; Watson, A T; Fritsch, M; Goetzen, K; Held, T; Koch, H; Lewandowski, B; Pelizaeus, M; Peters, K; Schröder, T; Steinke, M; Boyd, J T; Burke, J P; Cottingham, W N; Walker, D; Çuhadar-Dönszelmann, T; Fulsom, B G; Hearty, C; Knecht, N S; Mattison, T S; McKenna, J A; Khan, A; Kyberd, P; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, Yu K; Bondioli, M; Bruinsma, M; Chao, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M A; Mommsen, R K; Röthel, W; Stoker, D P; Abachi, S; Buchanan, C; Foulkes, S D; Gary, J W; Long, O; Shen, B C; Wang, K; Zhang, L; Del Re, D; Hadavand, H K; Hill, E J; Paar, H P; Rahatlou, S; Sharma, V; Berryhill, J W; Campagnari, C; Cunha, A; Dahmes, B; Hong, T M; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Nesom, G; Schalk, T; Schumm, B A; Seiden, A; Spradlin, P; Williams, D C; Wilson, M G; Albert, J; Chen, E; Dubois-Felsmann, G P; Dvoretskii, A; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Ryd, A; Samuel, A; Andreassen, R; Mancinelli, G; Meadows, B T; Sokoloff, M D; Antillon, E A; Blanc, F; Bloom, P C; Chen, S; Ford, W T; Hirschauer, J F; Kreisel, A; Nauenberg, U; Olivas, A; Ruddick, W O; Smith, J G; Ulmer, K A; Wagner, S R; Zhang, J; Chen, A; Eckhart, E A; Soffer, A; Toki, W H; Wilson, R J; Winklmeier, F; Zeng, Q; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Spaan, B; Brandt, T; Klose, V; Lacker, H M; Nogowski, R; Petzold, A; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Grenier, P; Latour, Y; Thiebaux, C; Verderi, M; Bard, D J; Clark, P J; Gradl, W; Muheim, F; Playfer, S; Xie, Y; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cibinetto, G; Luppi, E; Negrini, M; Piemontese, L; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; De Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Zallo, A; Buzzo, A; Capra, R; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Brandenburg, G; Chaisanguanthum, K S; Morii, M; Wu, J; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bhimji, W; Bowerman, D A; Dauncey, P D; Egede, U; Flack, R L; Gaillard, J R; Nash, J A; Nikolich, M B; Panduro-Vazquez, W; Chai, X; Charles, M J; Mader, W F; Mallik, U; Ziegler, V; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Schott, G; Arnaud, N; Davier, M; Grosdidier, G; Höcker, A; Le Diberder, F R; Lepeltier, V; Lutz, A M; Oyanguren, A; Petersen, T C; Pruvot, S; Rodier, S; Roudeau, P; Schune, M H; Stocchi, A; Wang, W F; Wormser, G; Cheng, C H; Lange, D J; Wright, D M; Chavez, C A; Forster, I J; Fry, J R; Gabathuler, E; Gamet, R; George, K A; Hutchcroft, D E; Payne, D J; Schofield, K C; Touramanis, C; Bevan, A J; Di Lodovico, F; Menges, W; Sacco, R; Brown, C L; Cowan, G; Flächer, H U; Hopkins, D A; Jackson, P S; McMahon, T R; Ricciardi, S; Salvatore, F; Davis, C L; Allison, J; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Kelly, M P; Lafferty, G D; Naisbit, M T; Williams, J C; Yi, J I; Chen, C; Hulsbergen, W D; Jawahery, A; Kovalskyi, D; Lae, C K; Roberts, D A; Simi, G; Blaylock, G; Dallapiccola, C; Hertzbach, S S; Li, X; Moore, T B; Saremi, S; Stängle, H; Willocq, S Y; Cowan, R; Koeneke, K; Sciolla, G; Sekula, S J; Spitznagel, M; Taylor, F; Yamamoto, R K; Kim, H; Patel, P M; Potter, C T; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Reidy, J; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; Cavallo, N; De Nardo, Gallieno; Fabozzi, F; Gatto, C; Lista, L; Monorchio, D; Piccolo, D; Sciacca, C; Baak, M; Bulten, H; Raven, G; Snoek, H L; Jessop, C P; LoSecco, J M; Allmendinger, T; Benelli, G; Gan, K K; Honscheid, K; Hufnagel, D; Jackson, P D; Kagan, H; Kass, R; Pulliam, T; Rahimi, A M; Ter-Antonian, R; Wong, Q K; Blount, N L; Brau, J E; Frey, R; Igonkina, O; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Galeazzi, F; Gaz, A; Margoni, M; Morandin, M; Pompili, A; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Benayoun, M; Chauveau, J; David, P; Del Buono, L; La Vaissière, C de; Hamon, O; Hartfiel, B L; John, M J J; Leruste, P; Malcles, J; Ocariz, J; Roos, L; Therin, G; Behera, P K; Gladney, L; Panetta, J; Biasini, M; Covarelli, R; Pioppi, M; Angelini, C; Batignani, G; Bettarini, S; Bucci, F; Calderini, G; Carpinelli, M; Cenci, R; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Mazur, M A; Morganti, M; Neri, N; Paoloni, E; Rama, M; Rizzo, G; Walsh, J; Haire, M; Judd, D; Wagoner, D E; Biesiada, J; Danielson, N; Elmer, P; Lau, Y P; Lü, C; Olsen, J; Smith, A J S; Telnov, A V; Bellini, F; Cavoto, G; D'Orazio, A; Di, E; Marco; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Li Gioi, L; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Safai-Tehrani, F; Voena, C; Schröder, H; Waldi, R; Adye, T; De Groot, N; Franek, B; Olaiya, E O; Wilson, F F; Emery, S; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, Witold; Legendre, M; Mayer, B; Vasseur, G; Yéche, C; Zito, M; Park, W; Purohit, M V; Weidemann, A W; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Berger, N; Boyarski, A M; Claus, R; Coleman, J P; Convery, M R; Cristinziani, M; Dingfelder, J C; Dong, D; Dorfan, J; Dujmic, D; Dunwoodie, W M; Field, R C; Glanzman, T; Gowdy, S J; Halyo, V; Hast, C; Hrynóva, T; Innes, W R; Kelsey, M H; Kim, P; Kocian, M L; Leith, D W G S; Libby, J; Luitz, S; Lüth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Müller, D R; O'Grady, C P; Ozcan, V E; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Stelzer, J; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Vavra, J; Van Bakel, N; Weaver, M; Weinstein, A J R; Wisniewski, W J; Wittgen, M; Wright, D H; Yarritu, A K; Yi, K; Young, C C; Burchat, P R; Edwards, A J; Majewski, S A; Petersen, B A; Roat, C; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Jain, V; Pan, B; Saeed, M A; Wappler, F R; Zain, S B; Bugg, W; Krishnamurthy, M; Spanier, S M; Eckmann, R; Ritchie, J L; Satpathy, A; Schwitters, R F; Izen, J M; Kitayama, I; Lou, X C; Ye, S; Bianchi, F; Bóna, M; Gallo, F; Gamba, D; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Dittongo, S; Grancagnolo, S; Lanceri, L; Vitale, L; Azzolini, V; Martínez-Vidal, F; Panvini, R S; Banerjee, S; Bhuyan, B; Brown, C M; Fortin, D; Hamano, K; Kowalewski, R V; Nugent, I M; Roney, J M; Sobie, R J; Back, J J; Harrison, P F; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Cheng, B; Dasu, S; Datta, M; Eichenbaum, A M; Flood, K T; Graham, M T; Hollar, J J; Johnson, J R; Kutter, P E; Li, H; Liu, R; Mellado, B; Mihályi, A; Mohapatra, A K; Pan, Y; Pierini, M; Prepost, R; Tan, P; Wu, S L; Yu, Z; Neal, H

    2006-01-01

    We describe searches for decays to two-body charmless final states eta' eta, eta' pi0 and eta pi0 of B0 mesons produced in e+e- annihilation. The data, collected with the BaBar detector at the Stanford Linear Accelerator Center, represent 232 million produced B-anti-B pairs. The results for branching fractions are, in units of 10^-6 (upper limits at 90% C.L.): BF(B0 -> eta' eta) = 0.2 +0.7 -0.5 +/- 0.4 ( eta pi0) = 0.6 +0.5 -0.4 +/- 0.1 ( eta' pi0) = 0.8 +0.8 -0.6 +/- 0.1 (<2.1). The first error quoted is statistical and the second systematic.

  16. ACA Federal Upper Limits

    Data.gov (United States)

    U.S. Department of Health & Human Services — Affordable Care Act Federal Upper Limits (FUL) based on the weighted average of the most recently reported monthly average manufacturer price (AMP) for...

  17. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  18. Limit experiments of GARCH

    CERN Document Server

    Buchmann, Boris; 10.3150/10-BEJ328

    2012-01-01

    GARCH is one of the most prominent nonlinear time series models, both widely applied and thoroughly studied. Recently, it has been shown that the COGARCH model (which was introduced a few years ago by Kl\\"{u}ppelberg, Lindner and Maller) and Nelson's diffusion limit are the only functional continuous-time limits of GARCH in distribution. In contrast to Nelson's diffusion limit, COGARCH reproduces most of the stylized facts of financial time series. Since it has been proven that Nelson's diffusion is not asymptotically equivalent to GARCH in deficiency, in the present paper, we investigate the relation between GARCH and COGARCH in Le Cam's framework of statistical equivalence. We show that GARCH converges generically to COGARCH, even in deficiency, provided that the volatility processes are observed. Hence, from a theoretical point of view, COGARCH can indeed be considered as a continuous-time equivalent to GARCH. Otherwise, when the observations are incomplete, GARCH still has a limiting experiment, which we ...

  19. Limited Denial of Participation

    Data.gov (United States)

    Department of Housing and Urban Development — A Limited Denial of Participation (LDP) is an action taken by a HUD Field Office or the Deputy Assistant Secretary for Single Family (DASSF) or Multifamily (DASMF)...

  20. HOME Rent Limits

    Data.gov (United States)

    Department of Housing and Urban Development — In accordance with 24 CFR Part 92.252, HUD provides maximum HOME rent limits. The maximum HOME rents are the lesser of: The fair market rent for existing housing for...

  1. PLT rotating pumped limiter

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, S.A.; Budny, R.V.; Corso, V.; Boychuck, J.; Grisham, L.; Heifetz, D.; Hosea, J.; Luyber, S.; Loprest, P.; Manos, D.

    1984-07-01

    A limiter with a specially contoured front face and the ability to rotate during tokamak discharges has been installed in a PLT pump duct. These features have been selected to handle the unique particle removal and heat load requirements of ICRF heating and lower-hybrid current-drive experiments. The limiter has been conditioned and commissioned in an ion-beam test stand by irradiation with 1 MW power, 200 ms duration beams of 40 keV hydrogen ions. Operation in PLT during ohmic discharges has proven the ability of the limiter to reduce localized heating caused by energetic electron bombardment and to remove about 2% of the ions lost to the PLT walls and limiters.

  2. Limited Income and Resources

    Data.gov (United States)

    U.S. Department of Health & Human Services — Information for those with limited income and resources (those who may qualify for or already have the Low Income Subsidy to lower their prescription drug coverage...

  3. Limited Angle Tomography

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ho Kyung; Cho, Min Kook; Kim, Seong Sik [Pusan National University, Busan (Korea, Republic of)

    2007-07-01

    In computed tomography (CT), many situations are restricted to obtain enough number of projections or views to avoid artifacts such as streaking and geometrical distortion in the reconstructed images. Speed of motion of an object to be imaged can limit the number of views. Cardiovascular imaging is a representative example. Size of an object can also limit the complete traverse motion or geometrical complexity can obscure to be imaged at certain range of angles. These situations are frequently met in industrial nondestructive testing and evaluation. Dental CT also suffers from similar situation because cervical spine causes less x-ray penetration from some directions such that the available information is not sufficient for standard reconstruction algorithms. The limited angle tomography is now greatly paid attention as a new genre in medical and industrial imaging, popularly known as digital tomosynthesis. In this study, we introduce a modified filtered backprojection method in limited angle tomography and demonstrate its application for the dental imaging.

  4. SIS - Annual Catch Limit

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Annual Catch Limit (ACL) dataset within the Species Information System (SIS) contains information and data related to management reference points and catch data.

  5. Altruism and Reproductive Limitations

    Directory of Open Access Journals (Sweden)

    Carey J. Fitzgerald

    2009-04-01

    Full Text Available We examined how different types of reproductive limitations — functional (schizoid personality disorder and schizophrenia, physical (malnutrition, and sexual (bisexuality and homosexuality — influenced altruistic intentions toward hypothetical target individuals of differing degrees of relatedness (r = 0, .25, and .50. Participants were 312 undergraduate students who completed a questionnaire on altruism toward hypothetical friends, half-siblings, and siblings with these different types of reproductive limitations. Genetic relatedness and reproductive limitations did not influence altruistic decision-making when the cost of altruism was low but did as the cost of altruism increased, with participants being more likely to help a sibling over a half-sibling and a half-sibling over a friend. Participants also indicated they were more likely to help a healthy (control person over people with a reproductive limitation. Of the three types of reproductive limitations, functional limitations had the strongest effect on altruistic decision-making, indicating that people were less likely to help those who exhibit abnormal social behavior.

  6. Fundamental Limits of Cooperation

    CERN Document Server

    Lozano, Angel; Andrews, Jeffrey G

    2012-01-01

    Cooperation is viewed as a key ingredient for interference management in wireless systems. This paper shows that cooperation has fundamental limitations. The main result is that even full cooperation between transmitters cannot in general change an interference-limited network to a noise-limited network. The key idea is that there exists a spectral efficiency upper bound that is independent of the transmit power. First, a spectral efficiency upper bound is established for systems that rely on pilot-assisted channel estimation; in this framework, cooperation is shown to be possible only within clusters of limited size, which are subject to out-of-cluster interference whose power scales with that of the in-cluster signals. Second, an upper bound is also shown to exist when cooperation is through noncoherent communication; thus, the spectral efficiency limitation is not a by-product of the reliance on pilot-assisted channel estimation. Consequently, existing literature that routinely assumes the high-power spect...

  7. The quantum geometric limit

    CERN Document Server

    Lloyd, Seth

    2012-01-01

    This letter analyzes the limits that quantum mechanics imposes on the accuracy to which spacetime geometry can be measured. By applying the fundamental physical bounds to measurement accuracy to ensembles of clocks and signals moving in curved spacetime -- e.g., the global positioning system -- I derive a covariant version of the quantum geometric limit: the total number of ticks of clocks and clicks of detectors that can be contained in a four volume of spacetime of radius r and temporal extent t is less than or equal to rt/\\pi x_P t_P, where x_P, t_P are the Planck length and time. The quantum geometric limit bounds the number of events or `ops' that can take place in a four-volume of spacetime: each event is associated with a Planck-scale area. Conversely, I show that if each quantum event is associated with such an area, then Einstein's equations must hold. The quantum geometric limit is consistent with and complementary to the holographic bound which limits the number of bits that can exist within a spat...

  8. FANCM limits meiotic crossovers.

    Science.gov (United States)

    Crismani, Wayne; Girard, Chloé; Froger, Nicole; Pradillo, Mónica; Santos, Juan Luis; Chelysheva, Liudmila; Copenhaver, Gregory P; Horlow, Christine; Mercier, Raphaël

    2012-06-22

    The number of meiotic crossovers (COs) is tightly regulated within a narrow range, despite a large excess of molecular precursors. The factors that limit COs remain largely unknown. Here, using a genetic screen in Arabidopsis thaliana, we identified the highly conserved FANCM helicase, which is required for genome stability in humans and yeasts, as a major factor limiting meiotic CO formation. The fancm mutant has a threefold-increased CO frequency as compared to the wild type. These extra COs arise not from the pathway that accounts for most of the COs in wild type, but from an alternate, normally minor pathway. Thus, FANCM is a key factor imposing an upper limit on the number of meiotic COs, and its manipulation holds much promise for plant breeding.

  9. Quantum-Limited Spectroscopy

    CERN Document Server

    Truong, Gar-Wing; May, Eric F; Stace, Thomas M; Luiten, Andre N

    2015-01-01

    Spectroscopy has an illustrious history delivering serendipitous discoveries and providing a stringent testbed for new physical predictions, including applications from trace materials detection, to understanding the atmospheres of stars and planets, and even constraining cosmological models. Reaching fundamental-noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here we demonstrate a quantum-limited spectrometer that delivers high-precision measurements of the absorption lineshape. These measurements yield a ten-fold improvement in the accuracy of the excited-state (6P$_{1/2}$) hyperfine splitting in Cs, and reveals a breakdown in the well-known Voigt spectral profile. We develop a theoretical model that accounts for this breakdown, explaining the observations to within the shot-noise limit. Our model enables us to infer the thermal velocity-dispersion of the Cs vapour with an uncertainty of 35ppm within an hour. This allows us to determine a value for Boltzm...

  10. Quantum-limit spectroscopy

    CERN Document Server

    Ficek, Zbigniew

    2017-01-01

    This book covers the main ideas, methods, and recent developments of quantum-limit optical spectroscopy and applications to quantum information, resolution spectroscopy, measurements beyond quantum limits, measurement of decoherence, and entanglement. Quantum-limit spectroscopy lies at the frontier of current experimental and theoretical techniques, and is one of the areas of atomic spectroscopy where the quantization of the field is essential to predict and interpret the existing experimental results. Currently, there is an increasing interest in quantum and precision spectroscopy both theoretically and experimentally, due to significant progress in trapping and cooling of single atoms and ions. This progress allows one to explore in the most intimate detail the ways in which light interacts with atoms and to measure spectral properties and quantum effects with high precision. Moreover, it allows one to perform subtle tests of quantum mechanics on the single atom and single photon scale which were hardly eve...

  11. Limits of Lubrication in

    DEFF Research Database (Denmark)

    Olsson, David Dam

    by strategic surfaces in comparison to normal stainless steel surfaces implying a larger extent of bi-axial stretching. Numerical simulations have been applied in order to evaluate limits of lubrication in the simulative strip reduction based on predictions of critical parameters appearing in terms...... of temperature and contact pressure. The numerical models have been calibrated regarding friction and thermal contact resistance based on experimental results from actual testing conditions. It has been found that predictions of limits of lubrication are possible by numerical means and that the FE...

  12. Limits to responsible innovation

    NARCIS (Netherlands)

    de Hoop, E.; Pols, Auke; Romijn, Henny

    2016-01-01

    Responsible Innovation (RI) is a young field of research that has nevertheless had remarkable successes in dissemination within academic and political circles. However, there is relatively little awareness of its limits, blind spots and situations in which it cannot be used for actual innovation tra

  13. The Limits of Laughter.

    Science.gov (United States)

    Mindess, Harvey

    1983-01-01

    Three incidents which elucidate the limits of laughter are described. Most persons enjoy humor as comic relief, but when humor strikes a blow at something they hold dear, they find it very hard to laugh. People are upset by an irreverent attitude toward things they hold in esteem. (RM)

  14. Pushing the Photon Limit

    NARCIS (Netherlands)

    Wientjes, Emilie; Renger, Jan; Cogdell, Richard; Hulst, van Niek F.

    2016-01-01

    Nanoantennas are well-known for their effective role in fluorescence enhancement, both in excitation and emission. Enhancements of 3-4 orders of magnitude have been reported. Yet in practice, the photon emission is limited by saturation due to the time that a molecule spends in singlet and especi

  15. Tightening Home Purchase Limits

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    More Chinese cities will limit home purchase to cool the red-hot real estate market In June 2011,the average house price in 100 Chinese cities was 8,856 yuan ($1,373)per square meter.Of these cities,house prices in 75 of them increased

  16. Limitation of Auditors' Liability

    DEFF Research Database (Denmark)

    Werlauff, Erik; Foged-Ladefoged, Lise Kolding

    2014-01-01

    The article examines the question of whether rules on the limitation of auditors’ liability within the perspective of EU law are needed, and if so, which rules can provide an appropriate balance between the potential injured party’s interests and those of the auditing sector, including with respect...

  17. Limits of Software Reuse

    NARCIS (Netherlands)

    Holenderski, L.

    2006-01-01

    Software reuse is considered one of the main techniques to increasesoftware productivity. We present two simple mathematical argumentsthat show some theoretical limits of reuse. It turns out that the increase of productivity due to internal reuse is at most linear, farfrom the needed exponential gr

  18. Age Limit of Pediatrics.

    Science.gov (United States)

    Hardin, Amy Peykoff; Hackell, Jesse M

    2017-09-01

    Pediatrics is a multifaceted specialty that encompasses children's physical, psychosocial, developmental, and mental health. Pediatric care may begin periconceptionally and continues through gestation, infancy, childhood, adolescence, and young adulthood. Although adolescence and young adulthood are recognizable phases of life, an upper age limit is not easily demarcated and varies depending on the individual patient. The establishment of arbitrary age limits on pediatric care by health care providers should be discouraged. The decision to continue care with a pediatrician or pediatric medical or surgical subspecialist should be made solely by the patient (and family, when appropriate) and the physician and must take into account the physical and psychosocial needs of the patient and the abilities of the pediatric provider to meet these needs. Copyright © 2017 by the American Academy of Pediatrics.

  19. Limitations Of Infrared Thermography

    Science.gov (United States)

    Schott, John R.

    1983-03-01

    The state of the art of quantitative infrared thermography is addressed. We are asking more and more of thermography in the field of energy conservation. An energy and dollar conscious public wants to know how much heat is being lost and how much money can be saved by retrofit. Many mission oriented approaches have been developed to address these questions. However, many fundamental questions about how thermography works and how far its capabilities can be pushed have not been addressed. In addition, the theoretical and practical limits of doing benefit cost studies with thermography have not been seriously addressed. This paper discusses the limitations of the current technology and describes many unanswered but important questions facing the future use of thermography for quantitative heat loss analysis.

  20. Telescopic limiting magnitudes

    Science.gov (United States)

    Schaefer, Bradley E.

    1990-01-01

    The prediction of the magnitude of the faintest star visible through a telescope by a visual observer is a difficult problem in physiology. Many prediction formulas have been advanced over the years, but most do not even consider the magnification used. Here, the prediction algorithm problem is attacked with two complimentary approaches: (1) First, a theoretical algorithm was developed based on physiological data for the sensitivity of the eye. This algorithm also accounts for the transmission of the atmosphere and the telescope, the brightness of the sky, the color of the star, the age of the observer, the aperture, and the magnification. (2) Second, 314 observed values for the limiting magnitude were collected as a test of the formula. It is found that the formula does accurately predict the average observed limiting magnitudes under all conditions.

  1. Current limiter circuit system

    Energy Technology Data Exchange (ETDEWEB)

    Witcher, Joseph Brandon; Bredemann, Michael V.

    2017-09-05

    An apparatus comprising a steady state sensing circuit, a switching circuit, and a detection circuit. The steady state sensing circuit is connected to a first, a second and a third node. The first node is connected to a first device, the second node is connected to a second device, and the steady state sensing circuit causes a scaled current to flow at the third node. The scaled current is proportional to a voltage difference between the first and second node. The switching circuit limits an amount of current that flows between the first and second device. The detection circuit is connected to the third node and the switching circuit. The detection circuit monitors the scaled current at the third node and controls the switching circuit to limit the amount of the current that flows between the first and second device when the scaled current is greater than a desired level.

  2. Limiting Temperatures in Multifragmentation

    CERN Document Server

    Trautmann, W

    2008-01-01

    The systematic data set on isotopic effects in spectator fragmentation collected recently at the GSI laboratory permits the investigation of the N/Z dependence of the nuclear caloric curve which is of interest in several respects. In particular, new light is shed on the proposed interpretation of chemical breakup temperatures as a manifestation of the limiting temperatures predicted by the Hartree-Fock model. The obtained results are discussed within the general context of temperature measurements in multifragmentation reactions.

  3. Limits of Nuclear Stability

    CERN Document Server

    Nerlo-Pomorska, B; Kleban, M

    2003-01-01

    The modern version of the liquid-drop model (LSD) is compared with the macroscopic part of the binding energy evaluated within the Hartree-Fock- Bogoliubov procedure with the Gogny force and the relativistic mean field theory. The parameters of a liquid-drop like mass formula which approximate on the average the self-consistent results are compared with other models. The limits of nuclear stability predicted by these models are discussed.

  4. Limits of proton conductivity.

    Science.gov (United States)

    Kreuer, Klaus-Dieter; Wohlfarth, Andreas

    2012-10-15

    Parasitic current seems to be the cause for the "highest proton conductivity" of a material reported to date. Kreuer and Wohlfarth verify this hypothesis by measuring the conductivity of the same materials after preparing them in a different way. They further explain the limits of proton conductivity and comment on the problems of determining the conductivity of small objects (e.g., whiskers, see picture).

  5. Elastic limit of silicane.

    Science.gov (United States)

    Peng, Qing; De, Suvranu

    2014-10-21

    Silicane is a fully hydrogenated silicene-a counterpart of graphene-having promising applications in hydrogen storage with capacities larger than 6 wt%. Knowledge of its elastic limit is critical in its applications as well as tailoring its electronic properties by strain. Here we investigate the mechanical response of silicane to various strains using first-principles calculations based on density functional theory. We illustrate that non-linear elastic behavior is prominent in two-dimensional nanomaterials as opposed to bulk materials. The elastic limits defined by ultimate tensile strains are 0.22, 0.28, and 0.25 along armchair, zigzag, and biaxial directions, respectively, an increase of 29%, 33%, and 24% respectively in reference to silicene. The in-plane stiffness and Poisson ratio are reduced by a factor of 16% and 26%, respectively. However, hydrogenation/dehydrogenation has little effect on its ultimate tensile strengths. We obtained high order elastic constants for a rigorous continuum description of the nonlinear elastic response. The limitation of second, third, fourth, and fifth order elastic constants are in the strain range of 0.02, 0.08, and 0.13, and 0.21, respectively. The pressure effect on the second order elastic constants and Poisson's ratio were predicted from the third order elastic constants. Our results could provide a safe guide for promising applications and strain-engineering the functions and properties of silicane monolayers.

  6. Limits to growth reconsidered.

    Science.gov (United States)

    Hagen, E E

    1972-01-01

    In their book, ''The Limits of Growth,'' the authors conclude that through pollution, exhaustion of natural resources, and limits to the food supply, the world faces a catastrophic fall in population and in living standards by the middle of the 21st century. The authors fail to state, however, 1 centrally important assumption underlying their results, but which is present through their omission of the contrary assumption. In their model the continuing technical progress that has been a primary feature of the material world for the past 200 years suddenly ceases. The assumptions of the model presented in ''Limits of Growth'' are not the assumptions other analysts make - these are strangely unrealistic. These assumptions require closer examination. The assumption concerning population assumes that the sole determinants of birthrates are the level of industrialization and the food supply. This is not good demography, for demographers have long recognized that it may have been the decrease in death rates, not industrialization or the rise in income, that caused the decrease in birthrates. Furthermore, their theory that many of the natural resources are irreplacable is like the belief that the sun revolves around the earth. It is obvious and false. It neglects that part of technical process which includes invention of new natural resources. Technical advance is needed and the following are some of the problems that technical advance must overcome: 1) a need to discover how to increase food production progressively while preventing the runoff of chemical fertilizers from the soil into waterways, 2) the ''natural'' minerals on which until recently all have depended are ''biodegradable,'' 3) there is a similar problem with radioactive nuclear wastes; 4) energy must dissipate into heat; and 5) there is a need to hasten the decline in birthrates throughout the world. In conclusion, indefinitely continuing growth is not regarded as desirable only as possible.

  7. Orind Refractories Limited

    Institute of Scientific and Technical Information of China (English)

    Mr R. Mishra; Group Manging Director

    2005-01-01

    @@ "Sight can be acquired, Vision cannot". Orind Refractories Limited (ORIND), China was formed with this rare vision. At a time when the world was testing the tepid waters of China; Mr. Ravin Jhunjhunwala, Chairman of ORIND and the management of ORIND India had looked over the Great Wall to begin a journey of success. Incorported on 18th August 1994 with an initial investment of USD 5 million, ORL caters to the ever-demanding needs of the steel industry and beyond. Incidentally ORIND was the first wholly owned India company to set up base in China. Pesently, ORIND China has a 616 strong work force including 23 expatriates.

  8. Drinking to the Limit

    DEFF Research Database (Denmark)

    Järvinen, Margaretha; Ellersgaard, Christoph Houman; Larsen, Anton Grau

    2014-01-01

    The aim of this article is to analyse social status differences in alcohol norms and practices seen from the perspective of ‘health governance’. Survey data on 1442 employees in a middle-sized, Danish firm are used to construct a Bourdieu-inspired social space, tied to four forms of capital: econ...... by the Danish National Health Board. Rather, this article identifies a relatively large group of high-positioned respondents balancing at the limits of risky drinking – or transgressing them, if measured by international standards....

  9. Limitations in forensic odontology

    Directory of Open Access Journals (Sweden)

    B Kavitha

    2009-01-01

    Full Text Available The concept of using dental evidence in forensic investigation has kindled so much interest in the recent past that forensic odontology is even suggested as the single positive identification method to solve certain forensic cases. In this process, the shortcomings in forensic odontology though few are overlooked. These discrepancies associated with various methods are to be weighed cautiously to make forensic odontology a more accurate, reliable, and reproducible investigatory science. In this paper, we present our understanding of the limitations in various methods employed in forensic odontology.

  10. Marketing with limited budget

    OpenAIRE

    Smirnova, Daria

    2017-01-01

    The purpose of this research-based thesis was to get an idea how managers of two small resembling hotels of a specific region deal with marketing process with a limited budget. In addition, the aim of the thesis was to examine if hotel managers who were interviewed perceive marketing only in the way of ‘promotion’ rather than marketing research, marketing mix and marketing environment theories. It was also found out if hotel managers of those hotels consider marketing as a key to successful h...

  11. Limits to biofuels

    Directory of Open Access Journals (Sweden)

    Johansson S.

    2013-06-01

    Full Text Available Biofuel production is dependent upon agriculture and forestry systems, and the expectations of future biofuel potential are high. A study of the global food production and biofuel production from edible crops implies that biofuel produced from edible parts of crops lead to a global deficit of food. This is rather well known, which is why there is a strong urge to develop biofuel systems that make use of residues or products from forest to eliminate competition with food production. However, biofuel from agro-residues still depend upon the crop production system, and there are many parameters to deal with in order to investigate the sustainability of biofuel production. There is a theoretical limit to how much biofuel can be achieved globally from agro-residues and this amounts to approximately one third of todays’ use of fossil fuels in the transport sector. In reality this theoretical potential may be eliminated by the energy use in the biomass-conversion technologies and production systems, depending on what type of assessment method is used. By surveying existing studies on biofuel conversion the theoretical limit of biofuels from 2010 years’ agricultural production was found to be either non-existent due to energy consumption in the conversion process, or up to 2–6000TWh (biogas from residues and waste and ethanol from woody biomass in the more optimistic cases.

  12. Smoothness of limit functors

    Indian Academy of Sciences (India)

    Benedictus Margaux

    2015-05-01

    Let be a scheme. Assume that we are given an action of the one dimensional split torus $\\mathbb{G}_{m,S}$ on a smooth affine -scheme $\\mathfrak{X}$. We consider the limit (also called attractor) subfunctor $\\mathfrak{X}_{}$ consisting of points whose orbit under the given action `admits a limit at 0’. We show that $\\mathfrak{X}_{}$ is representable by a smooth closed subscheme of $\\mathfrak{X}$. This result generalizes a theorem of Conrad et al. (Pseudo-reductive groups (2010) Cambridge Univ. Press) where the case when $\\mathfrak{X}$ is an affine smooth group and $\\mathbb{G}_{m,S}$ acts as a group automorphisms of $\\mathfrak{X}$ is considered. It also occurs as a special case of a recent result by Drinfeld on the action of $\\mathbb{G}_{m,S}$ on algebraic spaces (Proposition 1.4.20 of Drinfeld V, On algebraic spaces with an action of $\\mathfrak{G}_{m}$, preprint 2013) in case is of finite type over a field.

  13. Limitations of inclusive fitness.

    Science.gov (United States)

    Allen, Benjamin; Nowak, Martin A; Wilson, Edward O

    2013-12-10

    Until recently, inclusive fitness has been widely accepted as a general method to explain the evolution of social behavior. Affirming and expanding earlier criticism, we demonstrate that inclusive fitness is instead a limited concept, which exists only for a small subset of evolutionary processes. Inclusive fitness assumes that personal fitness is the sum of additive components caused by individual actions. This assumption does not hold for the majority of evolutionary processes or scenarios. To sidestep this limitation, inclusive fitness theorists have proposed a method using linear regression. On the basis of this method, it is claimed that inclusive fitness theory (i) predicts the direction of allele frequency changes, (ii) reveals the reasons for these changes, (iii) is as general as natural selection, and (iv) provides a universal design principle for evolution. In this paper we evaluate these claims, and show that all of them are unfounded. If the objective is to analyze whether mutations that modify social behavior are favored or opposed by natural selection, then no aspect of inclusive fitness theory is needed.

  14. (Limiting the greenhouse effect)

    Energy Technology Data Exchange (ETDEWEB)

    Rayner, S.

    1991-01-07

    Traveler attended the Dahlem Research Conference organized by the Freien Universitat, Berlin. The subject of the conference was Limiting the Greenhouse Effect: Options for Controlling Atmospheric CO{sub 2} Accumulation. Like all Dahlem workshops, this was a meeting of scientific experts, although the disciplines represented were broader than usual, ranging across anthropology, economics, international relations, forestry, engineering, and atmospheric chemistry. Participation by scientists from developing countries was limited. The conference was divided into four multidisciplinary working groups. Traveler acted as moderator for Group 3 which examined the question What knowledge is required to tackle the principal social and institutional barriers to reducing CO{sub 2} emissions'' The working rapporteur was Jesse Ausubel of Rockefeller University. Other working groups examined the economic costs, benefits, and technical feasibility of options to reduce emissions per unit of energy service; the options for reducing energy use per unit of GNP; and the significant of linkage between strategies to reduce CO{sub 2} emissions and other goals. Draft reports of the working groups are appended. Overall, the conference identified a number of important research needs in all four areas. It may prove particularly important in bringing the social and institutional research needs relevant to climate change closer to the forefront of the scientific and policy communities than hitherto.

  15. Array Antenna Limitations

    CERN Document Server

    Jonsson, B L G; Hussain, N

    2013-01-01

    This letter defines a physical bound based array figure of merit that provides a tool to compare the performance of both single and multi-band array antennas with respect to return-loss, thickness of the array over the ground-plane, and scan-range. The result is based on a sum-rule result of Rozanov-type for linear polarization. For single-band antennas it extends an existing limit for a given fixed scan-angle to include the whole scan-range of the array, as well as the unit-cell structure in the bound. The letter ends with an investigation of the array figure of merit for some wideband and/or wide-scan antennas with linear polarization. We find arrays with a figure of merit >0.6 that empirically defines high-performance antennas with respect to this measure.

  16. Personal Freedom beyond Limits

    Directory of Open Access Journals (Sweden)

    Juan Fernando Sellés

    2013-07-01

    Full Text Available In this work we distinguish between freedom in the human manifestations (intelligence, will,actions and personal freedom in the personal intimacy. This second is beyond the freedom reached bythe classic and modern thought, since it takes root in the personnel act of being. Because of it, it is not possible to characterize this freedom like the classic description as ‘domain over the own acts’, becauseit is a description of ‘categorial’ order; neither like present day ‘autonomy’ or ‘independence’, becausethe existence of one person alone is impossible, since ‘person’ means relation, personal free openingto other persons, description of the ‘transcendental’ order and, therefore, to the margin of limits.

  17. Universal Limit on Communication

    CERN Document Server

    Bousso, Raphael

    2016-01-01

    I derive a universal upper bound on the capacity of any communication channel between two distant systems. The Holevo quantity, and hence the mutual information, is at most of order $E \\Delta t / \\hbar$, where $E$ the average energy of the signal, and $\\Delta t$ is the amount of time for which detectors operate. The bound does not depend on the size or mass of the emitting and receiving systems, nor on the nature of the signal. No restrictions on preparing and processing the signal are imposed. As an example, I consider the encoding of information in the transverse or angular position of a signal emitted and received by systems of arbitrarily large cross-section. In the limit of a large message space, quantum effects become important even if individual signals are classical, and the bound is upheld.

  18. Clinical limitations of Invisalign.

    Science.gov (United States)

    Phan, Xiem; Ling, Paul H

    2007-04-01

    Adult patients seeking orthodontic treatment are increasingly motivated by esthetic considerations. The majority of these patients reject wearing labial fixed appliances and are looking instead to more esthetic treatment options, including lingual orthodontics and Invisalign appliances. Since Align Technology introduced the Invisalign appliance in 1999 in an extensive public campaign, the appliance has gained tremendous attention from adult patients and dental professionals. The transparency of the Invisalign appliance enhances its esthetic appeal for those adult patients who are averse to wearing conventional labial fixed orthodontic appliances. Although guidelines about the types of malocclusions that this technique can treat exist, few clinical studies have assessed the effectiveness of the appliance. A few recent studies have outlined some of the limitations associated with this technique that clinicians should recognize early before choosing treatment options.

  19. The Limits to Relevance

    Science.gov (United States)

    Averill, M.; Briggle, A.

    2006-12-01

    Science policy and knowledge production lately have taken a pragmatic turn. Funding agencies increasingly are requiring scientists to explain the relevance of their work to society. This stems in part from mounting critiques of the "linear model" of knowledge production in which scientists operating according to their own interests or disciplinary standards are presumed to automatically produce knowledge that is of relevance outside of their narrow communities. Many contend that funded scientific research should be linked more directly to societal goals, which implies a shift in the kind of research that will be funded. While both authors support the concept of useful science, we question the exact meaning of "relevance" and the wisdom of allowing it to control research agendas. We hope to contribute to the conversation by thinking more critically about the meaning and limits of the term "relevance" and the trade-offs implicit in a narrow utilitarian approach. The paper will consider which interests tend to be privileged by an emphasis on relevance and address issues such as whose goals ought to be pursued and why, and who gets to decide. We will consider how relevance, narrowly construed, may actually limit the ultimate utility of scientific research. The paper also will reflect on the worthiness of research goals themselves and their relationship to a broader view of what it means to be human and to live in society. Just as there is more to being human than the pragmatic demands of daily life, there is more at issue with knowledge production than finding the most efficient ways to satisfy consumer preferences or fix near-term policy problems. We will conclude by calling for a balanced approach to funding research that addresses society's most pressing needs but also supports innovative research with less immediately apparent application.

  20. Human immune system mice: current potential and limitations for translational research on human antibody responses.

    Science.gov (United States)

    Vuyyuru, Raja; Patton, John; Manser, Tim

    2011-12-01

    It has recently become possible to generate chimeric mice durably engrafted with many components of the human immune system (HIS mice). We have characterized the maturation and function of the B cell compartment of HIS mice. The antibody response of HIS mice to T cell-dependent B cell antigens is limited, and contributing factors may be the general immaturity of the B cell compartment, infrequent helper T cells selected on human MHC class II antigens, and incomplete reconstitution of secondary lymphoid organs and their microenvironments. In contrast, HIS mice generate protective antibody responses to the bacterium Borrelia hermsii, which acts as a T cell-independent antigen in mice, but do not respond to purified polysaccharide antigens (PPS). We speculate that the anti-B. hermsii response of HIS mice is derived from an abundant B cell subset that may be analogous to B1 B cells in mice. We suggest that failure of HIS mice to respond to PPS is due to the lack of a B cell subset that may originate from adult bone marrow and is highly dependent on human interleukin-7 for development.

  1. CFO of CNOOC Limited Changed

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ CNOOC Limited announced on December 24 that Yang Hua, Senior Vice President of CNOOC Limited and President of CNOOC International Limied will succeed Dr.Mark Qiu as Chief Financial Officer effective on January 1,2005.

  2. Charter Halibut Limited Access Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This limited access system limits the number of charter vessels that may participate in the guided sport fishery for halibut in area 2C and 3A. NMFS issues a charter...

  3. Guidelines for setting speed limits

    CSIR Research Space (South Africa)

    Wium, DJW

    1986-02-01

    Full Text Available A method is described for setting the speed limit for a particular road section. Several speed limits based on different criteria are described for each of nine traffic and road factors. The most appropriate speed limit for each relevant factor...

  4. The Limits of Exercise Physiology

    DEFF Research Database (Denmark)

    Gabriel, Brendan M; Zierath, Juleen R

    2017-01-01

    Many of the established positive health benefits of exercise have been documented by historical discoveries in the field of exercise physiology. These investigations often assess limits: the limits of performance, or the limits of exercise-induced health benefits. Indeed, several key findings have...

  5. Interference and memory capacity limitations.

    Science.gov (United States)

    Endress, Ansgar D; Szabó, Szilárd

    2017-10-01

    Working memory (WM) is thought to have a fixed and limited capacity. However, the origins of these capacity limitations are debated, and generally attributed to active, attentional processes. Here, we show that the existence of interference among items in memory mathematically guarantees fixed and limited capacity limits under very general conditions, irrespective of any processing assumptions. Assuming that interference (a) increases with the number of interfering items and (b) brings memory performance to chance levels for large numbers of interfering items, capacity limits are a simple function of the relative influence of memorization and interference. In contrast, we show that time-based memory limitations do not lead to fixed memory capacity limitations that are independent of the timing properties of an experiment. We show that interference can mimic both slot-like and continuous resource-like memory limitations, suggesting that these types of memory performance might not be as different as commonly believed. We speculate that slot-like WM limitations might arise from crowding-like phenomena in memory when participants have to retrieve items. Further, based on earlier research on parallel attention and enumeration, we suggest that crowding-like phenomena might be a common reason for the 3 major cognitive capacity limitations. As suggested by Miller (1956) and Cowan (2001), these capacity limitations might arise because of a common reason, even though they likely rely on distinct processes. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Material limitations on the detection limit in refractometry.

    Science.gov (United States)

    Skafte-Pedersen, Peder; Nunes, Pedro S; Xiao, Sanshui; Mortensen, Niels Asger

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η, with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm) of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly.

  7. Material Limitations on the Detection Limit in Refractometry

    CERN Document Server

    Skafte-Pedersen, Peder; Xiao, Sanshui; Mortensen, Niels Asger; 10.3390/s91108382

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min{Dn} > eta with n+i*eta being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because silicon absorbs strongly.

  8. Material Limitations on the Detection Limit in Refractometry

    Directory of Open Access Journals (Sweden)

    Niels Asger Mortensen

    2009-10-01

    Full Text Available We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm of silicon the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly.

  9. Material limitations on the detection limit in refractometry

    DEFF Research Database (Denmark)

    Skafte-Pedersen, Peder; Nunes, Pedro; Xiao, Sanshui

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors...... and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in a bio-liquid environment, such as a water buffer. In the transparency window (λ ≳ 1100 nm) of silicon...... the detection limit becomes almost independent on the filling fraction, while in the visible, the detection limit depends strongly on the filling fraction because the silicon absorbs strongly....

  10. Material Limitations on the Detection Limit in Refractometry

    OpenAIRE

    Niels Asger Mortensen; Sanshui Xiao; Peder Skafte-Pedersen; Nunes, Pedro S.

    2009-01-01

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η, with n + iη being the complex refractive index of the material under refractometric investigation. Taking finite Q factors and filling fractions into account, the detection limit declines. As an example we discuss the fundamental limits of silicon-based high-Q resonators, such as photonic crystal resonators, for sensing in ...

  11. Determination of the Limiting Magnitude

    Science.gov (United States)

    Kingery, Aaron; Blaauw, Rhiannon

    2017-01-01

    The limiting magnitude of an optical camera system is an important property to understand since it is used to find the completeness limit of observations. Limiting magnitude depends on the hardware and software of the system, current weather conditions, and the angular speed of the objects observed. If an object exhibits a substantial angular rate during the exposure, its light spreads out over more pixels than the stationary stars. This spreading causes the limiting magnitude to be brighter when compared to the stellar limiting magnitude. The effect, which begins to become important when the object moves a full width at half max during a single exposure or video frame. For targets with high angular speeds or camera systems with narrow field of view or long exposures, this correction can be significant, up to several magnitudes. The stars in an image are often used to measure the limiting magnitude since they are stationary, have known brightness, and are present in large numbers, making the determination of the limiting magnitude fairly simple. In order to transform stellar limiting magnitude to object limiting magnitude, a correction must be applied accounting for the angular velocity. This technique is adopted in meteor and other fast-moving object observations, as the lack of a statistically significant sample of targets makes it virtually impossible to determine the limiting magnitude before the weather conditions change. While the weather is the dominant factor in observing satellites, the limiting magnitude for meteors also changes throughout the night due to the motion of a meteor shower or sporadic source radiant across the sky. This paper presents methods for determining the limiting stellar magnitude and the conversion to the target limiting magnitude.

  12. DISCUSSION ON DECISION LIMIT AND DETECTION LIMIT IN SPECTROSCOPY

    Institute of Scientific and Technical Information of China (English)

    郑仁圻; 余君岳; 等

    1995-01-01

    Based on fundamental arguments,the expressions for the decision limit and the detection limit both in the count domain and in the cout rate domain are derive4d.These expressions are found to be different from those shown in the existing literature.

  13. Welfare Dynamics under Time Limits

    OpenAIRE

    Jeff Grogger; Charles Michalopoulos

    2003-01-01

    Among the most important changes brought about by the Personal Responsibility and Work Opportunity Reconciliation Act of 1996 (PRWORA) is the imposition of time limits. In this paper, we analyze a simple model in which a potential welfare recipient chooses how to allocate her time-limited endowment of benefits so as to maximize her expected lifetime utility. Not surprisingly, the model reveals that time limits provide an incentive for the consumer to conserve, or bank, her benefits. More inte...

  14. Optimum shapes for pump limiters

    Energy Technology Data Exchange (ETDEWEB)

    Ulrickson, M.

    1982-05-01

    The design of a pump limiter depends strongly on the details of the plasma scrapeoff zone. A model has been developed which allows the transport coefficients in the scrapeoff to be functions of n and t. This model has been used to predict scrapeoff profiles for FED/INTOR. The profiles are used to find and analyze limiter profiles. The results suggest the use of limiter shapes which curve toward the plasma.

  15. A ciência como cultura do mundo contemporâneo: a utopia dos saberes das (biociências e a construção midiática do imaginário social Science as culture in the modern world: the utopia of knowledge in (biosciences and the media construction of social imaginary

    Directory of Open Access Journals (Sweden)

    Madel Luz

    2013-04-01

    Full Text Available O artigo trata essencialmente do papel das biociências, visto como uma cultura específica, no imaginário social contemporâneo, no que concerne à vida, à saúde e ao viver humano em todas as suas fases. Os meios de comunicação, sobretudo através da imprensa de divulgação de massa - sendo privilegiada no artigo a imprensa escrita - difundem para o conjunto da sociedade modos de pensar e agir derivadas das atividades científicas, em andamento ou finalizadas, na área das biociências, que compõem um campo disciplinar especializado de amplo espectro. Destacamos no texto a autoridade não apenas intelectual como moral do discurso normativo oriundo dessas atividades, face a outros discursos presentes na cultura, sejam eles tradicionais - de origem nativa ou externa, como as orientais - sejam eles paralelos atuais, como os das chamadas medicinas ou saberes terapêuticos alternativos derivados dos movimentos de contracultura que remontam aos anos setentas. Nossa hipótese é que esta influência normativa atinge áreas do viver e setores cada vez mais amplos das populações, sendo possível afirmar que as ciências sociais, sobretudo a sociologia, não vêm atribuindo à questão da vida e da saúde humanas a mesma importância que atribui a outros aspectos da vida social, e que é urgente pensar a cultura da vida e do viver veiculada pelas biociências.This article deals with the growing influence of the so called biosciences, a large scope of disciplines concerning life, mainly human life, its origin, "normal" characteristics and evolution processes, from birth to death, in present culture. We are particularly interested in the effects of the discoveries and controversies of the diffusion of results of the research process in social imaginary. Through the mass media divulgation -specially press, mainly the magazines having as its objective the scientific research diffusion, an ensemble of rules about the way of conducting "normal" live

  16. Limit cycles in quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Niemann, Patrick

    2015-04-27

    In this thesis we investigate Limit Cycles in Quantum Systems. Limit cycles are a renormalization group (RG) topology. When degrees of freedom are integrated out, the coupling constants flow periodically in a closed curve. The presence of limit cycles is restricted by the necessary condition of discrete scale invariance. A signature of discrete scale invariance and limit cycles is log-periodic behavior. The first part of this thesis is concerned with the study of limit cycles with the similarity renormalization group (SRG). Limit cycles are mainly investigated within conventional renormalization group frameworks, where degrees of freedom, which are larger than a given cutoff, are integrated out. In contrast, in the SRG potentials are unitarily transformed and thereby obtain a band-diagonal structure. The width of the band structure can be regarded as an effective cutoff. We investigate the appearance of limit cycles in the SRG evolution. Our aim is to extract signatures as well as the scaling factor of the limit cycle. We consider the 1/R{sup 2}-potential in a two-body system and a three-body system with large scattering lengths. Both systems display a limit cycle. Besides the frequently used kinetic energy generator we apply the exponential and the inverse generator. In the second part of this thesis, Limit Cycles at Finite Density, we examine the pole structure of the scattering amplitude for distinguishable fermions at zero temperature in the medium. Unequal masses and a filled Fermi sphere for each fermion species are considered. We focus on negative scattering lengths and the unitary limit. The properties of the three-body spectrum in the medium and implications for the phase structure of ultracold Fermi gases are discussed.

  17. Scientific Opinion on the safety and efficacy of L-threonine produced by Escherichia coli for all animal species, based on a dossier submitted by HELM AG on behalf of Star Lake Bioscience Co.

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP

    2014-06-01

    Full Text Available The product L-Threonine is a feed additive produced by fermentation with a genetically modified strain of Escherichia coli. L-Threonine is an essential amino acid for all animal species. It is commonly considered the second and third limiting amino acid in cereal-based diets for pigs and poultry, respectively. It is widely used in the feed industry to optimise dietary protein. The amino acid L-threonine itself is considered safe for the target animals, the consumer and the environment. However, the possible presence of the production strain and its recombinant DNA, including antibiotic resistance genes used in the genetic modification process, in the final product cannot be excluded. Consequently, the FEEDAP Panel cannot conclude on the safety of L-threonine produced by fermentation with such E. coli strain for the target animals, consumers and the environment. Regardless of the assessment of the genetic modification, the FEEDAP Panel has concerns regarding the safety of amino acids, including L-threonine, for target species when administered via water for drinking. From the results provided, it is concluded that there is no concern for users in respect of respiratory toxicity, or skin or eye irritancy. In the absence of any data on sensitisation, it is concluded that the product may have the potential to be a dermal sensitiser. The concerns regarding the safety of the genetic modification may also have implications for the safety of the user. The product L-threonine is an efficacious source of supplemented amino acid which helps to maintain or restore the adequate balance of dietary amino acids for all non-ruminant species. Supplemental L-threonine is degraded by ruminal microorganisms if not given in a protected form.

  18. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2008-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., Tulving & Patkau, 1962; Cowan, Chen, & Rouder, 2004), other research has suggested that it is limited by the length of the material to be recalled (e.g., Baddeley, Thomson, & Buchanan, 1975). We investigated this question by teaching new paired associations between words to create two-word chunks. The results suggest that both chunk capacity limits and length limits come into play. For the free recall of 12-word lists, 6 pre-learned pairs could be recalled about as well as 6 pre-exposed singletons, suggesting a chunk limit. However, for the serially-ordered recall of 8-word lists, 4 pre-learned pairs could be recalled about as well as 8 pre-exposed singletons, suggesting a length limit. Other conditions yielded intermediate results suggesting that sometimes both limits may operate together. PMID:16393043

  19. LimitS - A system for limit state analysis and optimal material layout

    DEFF Research Database (Denmark)

    Damkilde, Lars; Krenk, Steen

    1997-01-01

    A system LimitS for limit state analysis and material optimization has been developed and implemented in a PC environment. The program is formulated in a general finite element format with stress-based elements. The solution method is based on the lower-bound theorem, where an optimal stress...... the statics and kinematics of the collapse mode are determined via the dual variables of the LP-problem. In LimitS the following element types are implemented: two- and three-dimensional beam elements; truss elements; triangular slab elements; and shear and stringer elements for plates with in-plane loading....... Examples of all three problem types are given including both limit state analysis and material optimization....

  20. LimitS - A system for limit state analysis and optimal material layout

    DEFF Research Database (Denmark)

    Damkilde, Lars; Krenk, Steen

    1997-01-01

    A system LimitS for limit state analysis and material optimization has been developed and implemented in a PC environment. The program is formulated in a general finite element format with stress-based elements. The solution method is based on the lower-bound theorem, where an optimal stress...... the statics and kinematics of the collapse mode are determined via the dual variables of the LP-problem. In LimitS the following element types are implemented: two- and three-dimensional beam elements; truss elements; triangular slab elements; and shear and stringer elements for plates with in-plane loading....... Examples of all three problem types are given including both limit state analysis and material optimization....

  1. Solubility limits on radionuclide dissolution

    Energy Technology Data Exchange (ETDEWEB)

    Kerrisk, J.F.

    1984-12-31

    This paper examines the effects of solubility in limiting dissolution rates of a number of important radionuclides from spent fuel and high-level waste. Two simple dissolution models were used for calculations that would be characteristics of a Yucca Mountain repository. A saturation-limited dissolution model, in which the water flowing through the repository is assumed to be saturated with each waste element, is very conservative in that it overestimates dissolution rates. A diffusion-limited dissolution model, in which element-dissolution rates are limited by diffusion of waste elements into water flowing past the waste, is more realistic, but it is subject to some uncertainty at this time. Dissolution rates of some elements (Pu, Am, Sn, Th, Zr, Sm) are always limited by solubility. Dissolution rates of other elements (Cs, Tc, Np, Sr, C, I) are never solubility limited; their release would be limited by dissolution of the bulk waste form. Still other elements (U, Cm, Ni, Ra) show solubility-limited dissolution under some conditions. 9 references, 3 tables.

  2. Delving into Limits of Sequences

    Science.gov (United States)

    Cory, Beth; Smith, Ken W.

    2011-01-01

    Limits are foundational to the central concepts of calculus. However, the authors' experiences with students and educational research abound with examples of students' misconceptions about limits and infinity. The authors wanted calculus students to understand, appreciate, and enjoy their first introduction to advanced mathematical thought. Thus,…

  3. Delving into Limits of Sequences

    Science.gov (United States)

    Cory, Beth; Smith, Ken W.

    2011-01-01

    Limits are foundational to the central concepts of calculus. However, the authors' experiences with students and educational research abound with examples of students' misconceptions about limits and infinity. The authors wanted calculus students to understand, appreciate, and enjoy their first introduction to advanced mathematical thought. Thus,…

  4. Beam-limiting and radiation-limiting interlocks

    Energy Technology Data Exchange (ETDEWEB)

    Macek, R.J.

    1996-04-01

    This paper reviews several aspects of beam-limiting and radiation- limiting interlocks used for personnel protection at high-intensity accelerators. It is based heavily on the experience at the Los Alamos Neutron Science Center (LANSCE) where instrumentation-based protection is used extensively. Topics include the need for ``active`` protection systems, system requirements, design criteria, and means of achieving and assessing acceptable reliability. The experience with several specific devices (ion chamber-based beam loss interlock, beam current limiter interlock, and neutron radiation interlock) designed and/or deployed to these requirements and criteria is evaluated.

  5. Search for the supersymmetric partner of the top quark in the channel stop anti-stop {yields} e{sup {+-}} {mu}{sup {+-}} sneutrino anti-sneutrino b anti-b in D0 experiment at the Tevatron. Calibration of the D0 electromagnetic calorimeter; Recherche du partenaire supersymetrique du quark top dans le canal stop anti-stop {yields} e{sup {+-}} {mu}{sup {+-}} sneutrino anti-sneutrino b anti-b au sein de l'experience D0 aupres du TeVatron. Calibration du calorimetre electromagnetique de D0

    Energy Technology Data Exchange (ETDEWEB)

    Mendes, A

    2006-10-15

    Symmetry is one of the most natural extensions of the standard model. At low energy it may consist in the Minimal Supersymmetric Standard Model which is the framework chosen to perform the search of the stop with 350 pb{sup -1} of data collected by D0 during the run-IIa period of the Tevatron. We selected the events with an electron, a muon, missing transverse energy and non-isolated tracks, signature for the stop decay in 3 particles (stop {yields} bl sneutrino). Since no significant excess of signal is seen, the results are interpreted in terms of limit on the stop production cross-sections, in such a way that we extend the existing exclusion region in the parameter space (m(stop), m(sneutrino)) up to stop masses of 168 (140) GeV for sneutrino masses of 50 (94) GeV. Finally, because of the crucial role of the electromagnetic calorimeter, a fine calibration was performed using Z {yields} e{sup +}e{sup -} events, which improved significantly the energy resolution. (author)

  6. Force Limited Vibration Testing Monograph

    Science.gov (United States)

    Scharton, Terry D.

    1997-01-01

    The practice of limiting the shaker force in vibration tests was investigated at the NASA Jet Propulsion Laboratory (JPL) in 1990 after the mechanical failure of an aerospace component during a vibration test. Now force limiting is used in almost every major vibration test at JPL and in many vibration tests at NASA Goddard Space Flight Center (GSFC) and at many aerospace contractors. The basic ideas behind force limiting have been in the literature for several decades, but the piezo-electric force transducers necessary to conveniently implement force limiting have been available only in the last decade. In 1993, funding was obtained from the NASA headquarters Office of Chief Engineer to develop and document the technology needed to establish force limited vibration testing as a standard approach available to all NASA centers and aerospace contractors. This monograph is the final report on that effort and discusses the history, theory, and applications of the method in some detail.

  7. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2005-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., N. Cowan, Z. Chen, & J. N. Rouder, 2004; E. Tulving & J. E. Patkau, 1962), other research has suggested that it is limited by the length of the material to be recalled (e.g., A. D. Baddeley, N. Thomson, &…

  8. Physical limits in semiconductor electronics.

    Science.gov (United States)

    Keyes, R W

    1977-03-18

    Although the limitations of the methods of lithography in use at a particular time are easily recognized and attract substantial attention, experience shows that technological ingenuity keeps pushing them to ever-smaller dimensions. There seems to be no fundamental reason to expect that lithographic limits will not continue to recede. The limits to the advance of miniaturization are to be found in the ability of materials to withstand high electric fields and in the ability of packaging technology to remove heat from active components and provide for power distribution, signal interconnection, and flexible mechanical assembly.

  9. Fundamental Limits of Ultrathin Metasurfaces

    CERN Document Server

    Arbabi, Amir

    2014-01-01

    We present universal theoretical limits on the operation and performance of non-magnetic passive ultrathin metasurfaces. In particular, we prove that their local transmission, reflection, and polarization conversion coefficients are confined to limited regions of the complex plane. As a result, full control over the phase of the light transmitted through such metasurfaces cannot be achieved if the polarization of the light is not to be affected at the same time. We also establish fundamental limits on the maximum polarization conversion efficiency of these metasurfaces, and show that they cannot achieve more than 25% polarization conversion efficiency in transmission.

  10. The Limits to Giving Back

    Directory of Open Access Journals (Sweden)

    Jade S. Sasser

    2014-07-01

    Full Text Available In this thematic section, authors consider the limitations on giving back that they faced in field research, or saw others face. For some authors, their attempts at giving back were severely limited by the scope of their projects, or their understandings of local cultures or histories. For others, very specific circumstances and historical interventions of foreigners in certain places can limit how and to what extent a researcher is able to have a reciprocal relationship with the participating community. Some authors, by virtue of their lesser positions of power relative to those that they were studying, simply decided not to give back to those communities. In each article it becomes apparent that how and in what ways people give back is unique (and limited both to their personal values and the contexts in which they do research.

  11. OECD Maximum Residue Limit Calculator

    Science.gov (United States)

    With the goal of harmonizing the calculation of maximum residue limits (MRLs) across the Organisation for Economic Cooperation and Development, the OECD has developed an MRL Calculator. View the calculator.

  12. Multifamily Tax Subsidy Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Multifamily Tax Subsidy Projects (MTSP) Income Limits were developed to meet the requirements established by the Housing and Economic Recovery Act of 2008 (Public...

  13. Limits of Kansei - Kansei unlimited

    OpenAIRE

    BONGARD-BLANCHY, Kerstin; Bouchard, Carole; AOUSSAT, Améziane

    2013-01-01

    International audience; This article discusses momentary limitations of the Kansei Engineering methods. There are for example the focus on the evaluation of colour and form factors, as well as the highly time consuming creation of the questionnaires. To overcome these limits we firstly suggest the integration of word lists from related research fields, like sociology and cognitive psychology on product emotions in the Kansei questionnaires. Thereafter we present a study on the wide range of K...

  14. Limit cycle vibrations in turbomachinery

    Science.gov (United States)

    Ryan, S. G.

    1991-01-01

    The focus is on an examination of rotordynamic systems which are simultaneously susceptible to limit cycle instability and subharmonic response. Characteristics of each phenomenon are determined as well as their interrelationship. A normalized, single mass rotor model is examined as well as a complex model of the high pressure fuel turbopump and the Space Shuttle Main Engine. Entrainment of limit cycle instability by subharmonic response is demonstrated for both models. The nonuniqueness of the solution is also demonstrated.

  15. Time-limited optimal dynamics beyond the Quantum Speed Limit

    DEFF Research Database (Denmark)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan

    2015-01-01

    -off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian, and a classification......The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed has to be paid with a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven...

  16. Generalized Geometric Quantum Speed Limits

    Science.gov (United States)

    Pires, Diego Paiva; Cianciaruso, Marco; Céleri, Lucas C.; Adesso, Gerardo; Soares-Pinto, Diogo O.

    2016-04-01

    The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  17. Generalized Geometric Quantum Speed Limits

    Directory of Open Access Journals (Sweden)

    Diego Paiva Pires

    2016-06-01

    Full Text Available The attempt to gain a theoretical understanding of the concept of time in quantum mechanics has triggered significant progress towards the search for faster and more efficient quantum technologies. One of such advances consists in the interpretation of the time-energy uncertainty relations as lower bounds for the minimal evolution time between two distinguishable states of a quantum system, also known as quantum speed limits. We investigate how the nonuniqueness of a bona fide measure of distinguishability defined on the quantum-state space affects the quantum speed limits and can be exploited in order to derive improved bounds. Specifically, we establish an infinite family of quantum speed limits valid for unitary and nonunitary evolutions, based on an elegant information geometric formalism. Our work unifies and generalizes existing results on quantum speed limits and provides instances of novel bounds that are tighter than any established one based on the conventional quantum Fisher information. We illustrate our findings with relevant examples, demonstrating the importance of choosing different information metrics for open system dynamics, as well as clarifying the roles of classical populations versus quantum coherences, in the determination and saturation of the speed limits. Our results can find applications in the optimization and control of quantum technologies such as quantum computation and metrology, and might provide new insights in fundamental investigations of quantum thermodynamics.

  18. Why Property Tax Limitations Won't Limit Everyone's Taxes.

    Science.gov (United States)

    Picus, Larry

    Property tax limitation measures passed in 1978 by voters in California and Idaho contain provisions that apparently will reduce the equity of the property tax system in both states. Changes in assessment practices mandated by the new laws will shift the property tax burden away from business and commercial property and toward residential property…

  19. Ultimate physical limits to computation

    CERN Document Server

    Lloyd, S

    1999-01-01

    Computers are physical systems: what they can and cannot do is dictated by the laws of physics. In particular, the speed with which a physical device can process information is limited by its energy, and the amount of information that it can process is limited by the number of degrees of freedom it possesses. The way in which it processes information is determined by the forces of nature that the computer has at its disposal. This paper explores the fundamental physical limits of computation as determined by the speed of light c, the quantum scale as given by Planck's constant h, and the gravitational constant G. As an example, quantitative bounds are put to the computational power of an `ultimate laptop' with a mass of one kilogram confined to a volume of one liter.

  20. Derived limits for surface contamination

    CERN Document Server

    Wrixon, A D; Linsley, G S; White, D F

    1979-01-01

    Derived limits (DLs) for surface contamination were first established for use in the nuclear energy industry where a wide variety of radionuclides is encountered. They were later used in factories, hospitals, and universities, where the radionuclides used are normally fewer in number, either known or readily identifiable, and often of low toxicity. In these situations the current limits are frequently over-restrictive. This report describes a reassessment of the values in the light of more recent information on the possible pathways of exposure and the dose equivalent limits given in ICRP Publication 26. The reassessment is prompted also by the introduction of SI units. The results of the reassessment are used to produce a classification of DLs for all radionuclides for active and inactive area surfaces and for skin.

  1. Limitations on quantum key repeaters.

    Science.gov (United States)

    Bäuml, Stefan; Christandl, Matthias; Horodecki, Karol; Winter, Andreas

    2015-04-23

    A major application of quantum communication is the distribution of entangled particles for use in quantum key distribution. Owing to noise in the communication line, quantum key distribution is, in practice, limited to a distance of a few hundred kilometres, and can only be extended to longer distances by use of a quantum repeater, a device that performs entanglement distillation and quantum teleportation. The existence of noisy entangled states that are undistillable but nevertheless useful for quantum key distribution raises the question of the feasibility of a quantum key repeater, which would work beyond the limits of entanglement distillation, hence possibly tolerating higher noise levels than existing protocols. Here we exhibit fundamental limits on such a device in the form of bounds on the rate at which it may extract secure key. As a consequence, we give examples of states suitable for quantum key distribution but unsuitable for the most general quantum key repeater protocol.

  2. On Setting Limits for Supersymmetry

    Science.gov (United States)

    Simeon, Paul; Toback, David

    2004-10-01

    When searching for new particles two separate production mechanisms from the same theory may produce the same final state. For example, in gauge mediated supersymmetry breaking with \\chi^0_1arrow γ tildeG at least two production mechanisms, \\chi^0_1\\chi^±1 and \\chi^0_2\\chi^±_1, can cascade to produce events with two photons and missing transverse energy. If there is no discovery one wants to set the best possible limits. While it seems obvious that the goal is to find the lowest possible cross section limit, one should be careful and focus on excluding the largest amount of parameter space for a theory. We show that the combined cross section limit from both (or all) production mechanisms that produce the same final state is the most sensitive way to attempt to exclude a theory.

  3. The Newtonian Limit of Geometrostatics

    CERN Document Server

    Cederbaum, Carla

    2012-01-01

    This thesis discusses the Newtonian limit of General Relativity for static isolated systems with compactly supported matter. We call these systems "geometrostatic" to underline their geometric nature. We introduce new quasi-local notions of mass and center of mass that can be read off locally in the vicinity of the matter/black holes. We prove that these notions asymptotically coincide with ADM-mass and the Huisken-Yau CMC-center of mass. Moreover, we prove that they converge to Newtonian mass and center of mass in the Newtonian limit. The Newtonian limit is discussed in the language of Ehlers' frame theory. Furthermore, we prove several uniqueness claims in geometrostatics as well as other geometric and physical properties of these systems. We analyze equipotential sets, provide a pseudo-Newtonian reformulation of geometrostatics, and prove uniqueness of static photon spheres.

  4. Reconnectable Network with Limited Resources

    Institute of Scientific and Technical Information of China (English)

    史维更

    1991-01-01

    The reachability of a strongly connected network may be destroyed after link damage.Since many networks are directed or equivalent directed,connected by directed links with the potential for reversal.Therefore the reachability can be restored by reversing the direction of links.[1] has studied this matter under unlimited resources (transmitter and receiver) condition.In this paper the reconnectability of a network with limited number of receivers and transmitters is discussed.Also a linear time algorithm is given to find a reconnected reversal for limited receivers and transmitters.

  5. Paradox of simple limiter control.

    Science.gov (United States)

    Hilker, Frank M; Westerhoff, Frank H

    2006-05-01

    Chaos control by simple limiters is an easy-to-implement and effective method of stabilizing irregular fluctuations. Here we show that applying limiter control to a state variable can significantly shift its mean value. In many situations, this is a countereffective as well as unexpected result, when the aim of control is also to restrict the dynamics. We discuss this effect on the basis of a model of population dynamics and conclude that it can have severe implications for the management of pest species and epidemic spread.

  6. Perfinity Biosciences - Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    Determining the relationship between the function of an isolated protein and the function of that protein in a complex cellular environment is a significant analytical endeavor. Due to the time and cost associated with developing an enzyme linked immunoassay (ELISA), mass spectrometric approaches are playing an increasingly large role in protein analyses.

  7. Why DORA does not stand a chance in the biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Gloeser, J.

    2016-07-01

    The San Francisco Declaration on Research Assessment (DORA) has become emblematic for the international movement against the use of journal impact factors (JIFs) in researchassessment. This movement gained an institutional stronghold in Australia when in 2010, i.e. even before DORA, the Australian National Health and Medical research Council decided to remove JIFs from their assessment of grant proposals. Given the strong dependency of Australian researchers on funding from the research councils, one could expect the decisions by the funding councils to have an impact on the use of JIFs in individual research assessment. The aim of this paper is to demonstrate that there was no impact beyond a change of language in assessments and justifications of decisions, and to explain why this is the case. Interviews with officers of the two funding councils, university managers and researchers in cell biology and biostatistics were conducted in Australia in March 2016. The interviews explored the use of impact factors in seven roles of a biomedical researcher’s roleset, namely reader, author, group leader, grant applicant, reviewer of grant applications, university employee and university manager. The JIF solved three major problems for incumbents of the various roles: it reduced complexity, increased efficiency, and compensated for unfamiliarity in cases in which assessments were required but could not be conducted by judging content. Its use has not been changed by the research council’s intervention. JIFs are unlikely to be overcome as tools for research assessment in the life sciences unless another tool that solves the same problems is offered. (Author)

  8. Embedding Enterprise in Biosciences: Added Value for Employability

    Science.gov (United States)

    Watts, Carys; Wray, Katie; Kennedy, Ciara; Freeman, Paul; Trainer, Gareth

    2010-01-01

    Enterprise education at Newcastle University, UK, is embedded in the fabric of the curriculum via the Newcastle University Graduate Skills Framework. An example of this is the "Business for the Bioscientist" module. The authors discuss this module with regard to good practice, enterprise development and the wider arena of graduate…

  9. The bioscience revolution & the biological weapons threat: levers & interventions

    Directory of Open Access Journals (Sweden)

    Martin Greg

    2009-02-01

    Full Text Available Abstract In December 2008, the US Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism, released a report, World At Risk. The Report points to the fact that, not only is the use of a weapon of mass destruction in a terrorist attack before the end of 2013, more likely than not, but also to the fact that terrorists are more likely to be able to obtain and use biological weapons than nuclear. This paper examines the recommendations of the report in the context of the historic and geopolitical changes, in particular globalization. The authors highlight the "dual-use" dilemma, as described in the report, as the paradoxical use of technology developed for the benefit of mankind being used for sinister purposes. The mitigation of such a threat lies in broad stakeholder involvement and cooperation, including non-state actors, governments and the bio-tech industry itself. The importance of vigilance measures within the life science community is emphasized and, the authors propose, could include a web-based didactic course in bioterrorism and weapons of mass destruction identification. The site could outline safety protocols, have detailed disaster management tutorials, and could be specifically tailored for different subsets of industry and health professionals. The paper concludes with an endorsement of a multi-pronged approach including strong international guidelines and intelligence cooperation and preparatory measures such as the wide-spread use of detection systems as well as diagnostic decision support systems for bioterrorism detection at the local level.

  10. Cloning: Past, Present, and the Exciting Future. Breakthroughs in Bioscience.

    Science.gov (United States)

    Di Berardino, Marie A.

    This document explores the history of cloning by focusing on Dolly the Sheep, one of the first large animal clonings. The disadvantages and advantages of transgenic clones are discussed as well as the future implications of cloning from the perspective of human health. (Contains 10 resources.) (YDS)

  11. 77 FR 76841 - Lending Limits

    Science.gov (United States)

    2012-12-31

    ... surplus if the loan is fully secured. Section 5(u)(1) of the Home Owners' Loan Act (HOLA), 12 U.S.C. 1464...) of HOLA, 12 U.S.C. 1464(u)(2), includes exceptions to the lending limits for certain loans made by savings associations. These HOLA provisions apply to both Federal and state-chartered savings...

  12. Aluminum honeycomb impact limiter study

    Energy Technology Data Exchange (ETDEWEB)

    Yaksh, M.C.; Thompson, T.C. (Nuclear Assurance Corp., Norcross, GA (United States)); Nickell, R.E. (Applied Science and Technology, Inc., Poway, CA (United States))

    1991-07-01

    Design requirements for a cask transporting radioactive materials must include the condition of the 30-foot free fall of the cask onto an unyielding surface. To reduce the deceleration loads to a tolerable level for all the components of the cask, a component (impact limiter) is designed to absorb the kinetic energy. The material, shape, and method of attachment of the impact limiter to the cask body comprises the design of the impact limiter. The impact limiter material of interest is honeycomb aluminum, and the particular design examined was for the NAC Legal Weight Truck cask (NAC-LWT) for spent fuel from light water reactors. The NAC-LWT has a design weight of 52,000 pounds, and it has a nominal length of 200 inches. The report describes the numerical calculations embodied in the FADE program to determine the accelerations and crush strain resulting from an arbitrary height and angle of orientation. Since the program serves as a design tool, static tests are performed to assess the effect of the shell containing the honeycomb aluminum. The static tests and their results are contained in the study. The static tests are used to demonstrate for licensing purposes the level of accelerations imposed on the cask during a 30-foot drop. 3 refs., 41 figs., 15 tabs.

  13. Corporate Architecture and Limited Liability

    NARCIS (Netherlands)

    Couwenberg, Oscar

    2007-01-01

    Abstract This paper studies the effect of limited liability on corporate architecture. Corporate architecture refers to the use of governance instruments within the firm to control the behavior of employees. Four general instruments are defined that form the basis of the firm as a governance arrange

  14. Historical Drawbacks of Limited Liability

    Directory of Open Access Journals (Sweden)

    Denis Boyle

    2016-07-01

    Full Text Available Limited liability is a human invention which has facilitated enormous economic growth around the world, particularly since the time of its general application in advanced countries during the nineteenth century. The individual legal identity of companies, coupled with the limited liability of their owners, has provided protection for investors from the risks associated with their investments. It has thus contributed to increase the sources of capital available to finance projects which might otherwise have been considered unviable. However, the legal protection offered to investors has negative consequences for other participants in economies. Speculation in stock markets often damages society. It is very important to study the drawbacks of limited liability and to suggest modifications to achieve a more stable, less volatile, economic growth in the world. Although this article goes to some lengths to recognise the work of authors who emphasise the positive historical economic contribution of limited lability, its main objective is to provoke a reflection around texts which point out the drawbacks and propose solutions.

  15. Certifying Equality With Limited Interaction

    DEFF Research Database (Denmark)

    Brody, Joshua Eric; Chakrabarti, Amit; McGregor, Andrew

    2012-01-01

    by focusing on two subtle aspects. The first is to consider the {\\em expected} communication cost (at a worst-case input) for a protocol that uses limited interaction---i.e., a bounded number of rounds of communication---and whose error probability is zero or close to it. The second is to consider the {\\em...

  16. Limits to Scale and Scope

    DEFF Research Database (Denmark)

    Pedersen, Kurt; Sørensen, Peter

    2007-01-01

    slaughterhouse merger in 1890/91 between the established private slaughterhouses and the rising co-operative ones. The article deals with the question of the relevance of Chandler's concepts to the negotiation process and with that of the limits to the explanatory power of the framework. In order to answer...

  17. Explosion limits for combustible gases

    Institute of Scientific and Technical Information of China (English)

    TONG Min-ming; WU Guo-qing; HAO Ji-fei; DAI Xin-lian

    2009-01-01

    Combustible gases in coal mines are composed of methane, hydrogen, some multi-carbon alkane gases and other gases. Based on a numerical calculation, the explosion limits of combustible gases were studied, showing that these limits are related to the concentrations of different components in the mixture. With an increase of C4H10 and C6H14, the Lower ExplosionLimit (LEL) and Upper Explosion-Limit (UEL) of a combustible gas mixture will decrease clearly. For every 0.1% increase in C4H10 and C6H14, the LEL decreases by about 0.19% and the UEL by about 0.3%. The results also prove that, by increasing the amount of H2, the UEL of a combustible gas mixture will increase considerably. If the level of H2 increases by 0.1%, the UEL will increase by about 0.3%. However, H2 has only a small effect on the LEL of the combustible gas mixture. Our study provides a theoretical foundation for judging the explosion risk of an explosive gas mixture in mines.

  18. Landscape genetics and limiting factors

    Science.gov (United States)

    Samuel A. Cushman; Andrew J. Shirk; Erin L. Landguth

    2013-01-01

    Population connectivity is mediated by the movement of organisms or propagules through landscapes. However, little is known about how variation in the pattern of landscape mosaics affects the detectability of landscape genetic relationships. The goal of this paper is to explore the impacts of limiting factors on landscape genetic processes using simulation...

  19. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs refer

  20. Environmental risk limits for zinc

    NARCIS (Netherlands)

    Bodar CWM; SEC

    2007-01-01

    Environmental Riks Limits (ERLs) were derived for zinc. ERLs serve as advisory values to set environmental quality standards in the Netherlands. The ERLs for zinc closely follow the outcomes of earlier discussions on zinc within the Water Framework Directive and EC Regulation 793/93. The ERLs ref

  1. The Limits of Collaborative Evaluation.

    Science.gov (United States)

    Lewkowicz, Jo A.; Nunan, David

    1999-01-01

    Describes the development of a collaborative evaluation model and its application to a curricular innovation project within a secondary school system in Hong Kong. Focuses on the limits of collaboration in long-term evaluation projects with multiple stakeholders. (Author/VWL)

  2. The Limits of Collaborative Evaluation.

    Science.gov (United States)

    Lewkowicz, Jo A.; Nunan, David

    1999-01-01

    Describes the development of a collaborative evaluation model and its application to a curricular innovation project within a secondary school system in Hong Kong. Focuses on the limits of collaboration in long-term evaluation projects with multiple stakeholders. (Author/VWL)

  3. Active inrush-current limiter

    Science.gov (United States)

    Kichak, R. A.

    1977-01-01

    By stretching turn-on time from approximately 1 to 200 ms, effects of inrush current (and of associated large current spikes) and current rate of rise (dl/dt) are made potentially less severe. Limiter arrangement consists of time-variable impedance connected in series between input dc power source return and power circuit of converter.

  4. Setting time limits on tests

    NARCIS (Netherlands)

    Linden, van der Wim J.

    2011-01-01

    It is shown how the time limit on a test can be set to control the probability of a test taker running out of time before completing it. The probability is derived from the item parameters in the lognormal model for response times. Examples of curves representing the probability of running out of ti

  5. LIMITS OF THE EARTH BIOSPHERE

    Directory of Open Access Journals (Sweden)

    Karel KUDRNA

    2011-01-01

    Full Text Available Evaluation of the state of CO2 accumulation in the atmosphere demands knowledge on possibilities of the biosphere – its photosynthetizing apparatus, conditions and limits of absorption. A decisive precondition is to determine relation of CO2 accumulation by photosynthesis in dependence on the water balance, especially on its control quantity – transpiration, which is stabilized by supporting of underground waters.

  6. Limits of time in cosmology

    CERN Document Server

    Rugh, Svend E

    2016-01-01

    We provide a discussion of some main ideas in our project about the physical foundation of the time concept in cosmology. It is standard to point to the Planck scale (located at $\\sim 10^{-43}$ seconds after a fictitious "Big Bang" point) as a limit for how far back we may extrapolate the standard cosmological model. In our work we have suggested that there are several other (physically motivated) interesting limits -- located at least thirty orders of magnitude before the Planck time -- where the physical basis of the cosmological model and its time concept is progressively weakened. Some of these limits are connected to phase transitions in the early universe which gradually undermine the notion of 'standard clocks' widely employed in cosmology. Such considerations lead to a 'scale problem' for time which becomes particularly acute above the electroweak phase transition (before $\\sim 10^{-11}$ seconds). Other limits are due to problems of building up a cosmological reference frame, or even contemplating a s...

  7. Time-limited optimal dynamics beyond the Quantum Speed Limit

    DEFF Research Database (Denmark)

    Gajdacz, Miroslav; Das, Kunal K.; Arlt, Jan

    2015-01-01

    The quantum speed limit sets the minimum time required to transfer a quantum system completely into a given target state. At shorter times the higher operation speed has to be paid with a loss of fidelity. Here we quantify the trade-off between the fidelity and the duration in a system driven...... by a time-varying control. The problem is addressed in the framework of Hilbert space geometry offering an intuitive interpretation of optimal control algorithms. This approach leads to a necessary criterion for control optimality applicable as a measure of algorithm convergence. The time fidelity trade......-off expressed in terms of the direct Hilbert velocity provides a robust prediction of the quantum speed limit and allows to adapt the control optimization such that it yields a predefined fidelity. The results are verified numerically in a multilevel system with a constrained Hamiltonian, and a classification...

  8. 40 CFR 161.175 - Certified limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Certified limits. 161.175 Section 161... Certified limits. The applicant must propose certified limits for the ingredients in the product. Certified limits become legally binding limits upon approval of the application. Certified limits will apply to...

  9. Limitation and life in space

    Science.gov (United States)

    Israel, Marvin; Smith, T. Scott

    1986-08-01

    ``The Earth is the very quintescence of the human condition...,'' says Hannah Arendt. Georg Simmel writes: ``The stranger is by nature no `owner of soil'—soil not only in the physical, but also in the figurative sense of a life-substance which is fixed, if not in a point in space, at least in an ideal point of social environment.'' How will no longer being Earthbound affect persons' experience of themselves and of others? Space colonization offers an opportunity for new self-definition by the alteration of existing limits. Thus ``limitation'' is a useful concept for exploring the physical, social and psychological significance of the colonization of space. Will people seek the security of routine, of convention, of hierarchy as in the military model governing our present-day astronauts? or will they seek to maximize the freedom inherent in extraordinary living conditions—as bohemians, deviants, travelers?

  10. Swimming as a limit cycle

    CERN Document Server

    Jacobs, Henry O

    2012-01-01

    Steady swimming can be characterized as both periodic and stable. These characteristics are the very definition of limit cycles, and so we ask "Can we view swimming as a limit cycle?" In this paper we will find that the answer is "yes". We will define a class of dissipative systems which correspond to the passive dynamics of a body immersed in a Navier-Stokes fluid (i.e. the dynamics of a dead fish). Upon performing reduction by symmetry we will find a hyperbolically stable fixed point which corresponds to the stability of a dead fish in stagnant water. Given a periodic force on the shape of the body we will invoke the persistence theorem to assert the existence of a loop which approximately satisfies the exact equations of motion. If we lift this loop with a phase reconstruction formula we will find that the lifted loops are not loops, but stable trajectories which represent regular periodic motion reminiscent of swimming.

  11. Surfactants at the Design Limit.

    Science.gov (United States)

    Czajka, Adam; Hazell, Gavin; Eastoe, Julian

    2015-08-04

    This article analyzes how the individual structural elements of surfactant molecules affect surface properties, in particular, the point of reference defined by the limiting surface tension at the aqueous cmc, γcmc. Particular emphasis is given to how the chemical nature and structure of the hydrophobic tails influence γcmc. By comparing the three different classes of surfactants, fluorocarbon, silicone, and hydrocarbon, a generalized surface packing index is introduced which is independent of the chemical nature of the surfactants. This parameter ϕcmc represents the volume fraction of surfactant chain fragments in a surface film at the aqueous cmc. It is shown that ϕcmc is a useful index for understanding the limiting surface tension of surfactants and can be useful for designing new superefficient surfactants.

  12. Load limiting parachute inflation control

    Energy Technology Data Exchange (ETDEWEB)

    Redmond, J.; Hinnerichs, T.; Parker, G.

    1994-01-01

    Excessive deceleration forces experienced during high speed deployment of parachute systems can cause damage to the payload and the canopy fabric. Conventional reefing lines offer limited relief by temporarily restricting canopy inflation and limiting the peak deceleration load. However, the open-loop control provided by existing reefing devices restrict their use to a specific set of deployment conditions. In this paper, the sensing, processing, and actuation that are characteristic of adaptive structures form the basis of three concepts for active control of parachute inflation. These active control concepts are incorporated into a computer simulation of parachute inflation. Initial investigations indicate that these concepts promise enhanced performance as compared to conventional techniques for a nominal release. Furthermore, the ability of each controller to adapt to off-nominal release conditions is examined.

  13. Nuclear Structure at the Limits

    Energy Technology Data Exchange (ETDEWEB)

    Nazarewicz, W.

    1998-01-12

    One of the frontiers of today�s nuclear science is the �journey to the limits� of atomic charge and nuclear mass, of neutron-to-proton ratio, and of angular momentum. The tour to the limits is not only a quest for new, exciting phenomena, but the new data are expected, as well, to bring qualitatively new information about the fundamental properties of the nucleonic many-body system, the nature of the nuclear interaction, and nucleonic correlations at various energy-distance scales. In this series of lectures, current developments in nuclear structure at the limits are discussed from a theoretical perspective, mainly concentrating on medium-mass and heavy nuclei.

  14. Penrose Limits and Spacetime Singularities

    CERN Document Server

    Blau, Matthias; O'Loughlin, M; Papadopoulos, G; Blau, Matthias; Borunda, Monica; Loughlin, Martin O'; Papadopoulos, George

    2003-01-01

    We give a covariant characterisation of the Penrose plane wave limit: the plane wave profile matrix $A(u)$ is the restriction of the null geodesic deviation matrix (curvature tensor) of the original spacetime metric to the null geodesic, evaluated in a comoving frame. We also consider the Penrose limits of spacetime singularities and show that for a large class of black hole, cosmological and null singularities (of Szekeres-Iyers ``power-law type''), including those of the FRW and Schwarzschild metrics, the result is a singular homogeneous plane wave with profile $A(u)\\sim u^{-2}$, the scale invariance of the latter reflecting the power-law behaviour of the singularities.

  15. China Rare Earth Holdings Limited

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    China Rare Earth Holdings Limited is a large trans-area corporation and a public company listed in Hong Kong Stock Exchange (Name: China Rare Earth, Code: 0769), with headquarter in Hong Kong. Located on the bank of beautiful Taihu Lake, the subsidiary in Yinxing covers area of 200,000 m2. It has nearly 1,000 employees, 30% of whom are technical staffs. After self-administration and effort, the company passed ISO 9001: 2000 and ISO 14000 Certificaitons.

  16. Fundamental Limits to Cellular Sensing

    Science.gov (United States)

    ten Wolde, Pieter Rein; Becker, Nils B.; Ouldridge, Thomas E.; Mugler, Andrew

    2016-03-01

    In recent years experiments have demonstrated that living cells can measure low chemical concentrations with high precision, and much progress has been made in understanding what sets the fundamental limit to the precision of chemical sensing. Chemical concentration measurements start with the binding of ligand molecules to receptor proteins, which is an inherently noisy process, especially at low concentrations. The signaling networks that transmit the information on the ligand concentration from the receptors into the cell have to filter this receptor input noise as much as possible. These networks, however, are also intrinsically stochastic in nature, which means that they will also add noise to the transmitted signal. In this review, we will first discuss how the diffusive transport and binding of ligand to the receptor sets the receptor correlation time, which is the timescale over which fluctuations in the state of the receptor, arising from the stochastic receptor-ligand binding, decay. We then describe how downstream signaling pathways integrate these receptor-state fluctuations, and how the number of receptors, the receptor correlation time, and the effective integration time set by the downstream network, together impose a fundamental limit on the precision of sensing. We then discuss how cells can remove the receptor input noise while simultaneously suppressing the intrinsic noise in the signaling network. We describe why this mechanism of time integration requires three classes (groups) of resources—receptors and their integration time, readout molecules, energy—and how each resource class sets a fundamental sensing limit. We also briefly discuss the scheme of maximum-likelihood estimation, the role of receptor cooperativity, and how cellular copy protocols differ from canonical copy protocols typically considered in the computational literature, explaining why cellular sensing systems can never reach the Landauer limit on the optimal trade

  17. Summary of Dissolved Concentration Limits

    Energy Technology Data Exchange (ETDEWEB)

    Yueting Chen

    2001-06-11

    According to the Technical Work Plan titled Technical Work Plan for Waste Form Degradation Process Model Report for SR (CRWMS M&O 2000a), the purpose of this study is to perform abstractions on solubility limits of radioactive elements based on the process-level information and thermodynamic databases provided by Natural Environment Program Operations (NEPO) and Waste Package Operations (WPO). The scope of this analysis is to produce solubility limits as functions, distributions, or constants for all transported radioactive elements identified by the Performance Assessment Operations (PAO) radioisotope screening. Results from an expert elicitation for solubility limits of most radioactive elements were used in the previous Total System Performance Assessments (TSPAs). However, the elicitation conducted in 1993 does not meet the criteria set forth by the U.S. Nuclear Regulatory Commission (NRC) due to lack of documentation and traceability (Kotra et al. 1996, Section 3). Therefore, at the Waste Form Abstraction Workshop held on February 2-4, 1999, at Albuquerque, New Mexico, the Yucca Mountain Site Characterization Project (YMP) decided to develop geochemical models to study solubility for the proposed Monitored Geologic Repository. WPO/NEPO is to develop process-level solubility models, including review and compilation of relevant thermodynamic data. PAO's responsibility is to perform abstractions based on the process models and chemical conditions and to produce solubility distributions or response surfaces applicable to the proposed repository. The results of this analysis and conceptual model will feed the performance assessment for Total System Performance Assessment--Site Recommendation (TSPA-SR) and Total System Performance Assessment--License Application (TSPA-LA), and to the Waste Form Degradation Process Model Report section on concentration limits.

  18. Limit laws for exponential families

    OpenAIRE

    Balkema, August A.; Klüppelberg, Claudia; Resnick, Sidney I.

    1999-01-01

    For a real random variable [math] with distribution function [math] , define ¶ [math] ¶ The distribution [math] generates a natural exponential family of distribution functions [math] , where ¶ [math] ¶ We study the asymptotic behaviour of the distribution functions [math] as [math] increases to [math] . If [math] then [math] pointwise on [math] . It may still be possible to obtain a non-degenerate weak limit law [math] by choosing suitable scaling and centring constants [math] an...

  19. Problems of anthropogenic tritium limitation

    Directory of Open Access Journals (Sweden)

    Kochetkov О.A.

    2013-12-01

    Full Text Available This article contains the current situation in respect to the environmental concentrations of anthropogenic and natural tritium. There are presented and analyzed domestic standards for НТО of all Radiation Safety Standards (NRB, as well as the regulations analyzed for tritium in drinking water taken in other countries today. This article deals with the experience of limitation of tritium and focuses on the main problem of rationing of tritium — rationing of organically bound tritium.

  20. Limits to global groundwater consumption

    Science.gov (United States)

    de Graaf, I.; Van Beek, L. P.; Sutanudjaja, E.; Wada, Y.; Bierkens, M. F.

    2016-12-01

    Groundwater is the largest accessible freshwater resource worldwide and is of critical importance for irrigation, and so for global food security. For many regions of the world where groundwater abstraction exceeds groundwater recharge, persistent groundwater depletion occurs. A direct consequence of depletion is falling groundwater levels, reducing baseflows to rivers, harming ecosystems. Also, pumping costs increase, wells dry up and land subsidence can occur. Water demands are expected to increase further due to growing population, economic development and climate change, posing the urgent question how sustainable current water abstractions are worldwide and where and when these abstractions approach conceivable limits with all the associated problems. Here, we estimated past and future trends (1960-2050) in groundwater levels resulting from changes in abstractions and climate and predicted when limits of groundwater consumption are reached. We explored these limits by predicting where and when groundwater levels drop that low that groundwater becomes unattainable for abstractions and how river flows are affected. Water availabilities, abstractions, and lateral groundwater flows are simulated (5 arcmin. resolution) using a coupled version of the global hydrological model PCR-GLOBWB and a groundwater model based on MODFLOW. The groundwater model includes a parameterization of the worlds confined and unconfined aquifer systems, needed for a realistic simulation of groundwater head dynamics. Results show that, next to the existing regions experiencing groundwater depletion (like India, Pakistan, Central Valley) new regions will develop, e.g. Southern Europe, the Middle East, and Africa. Using a limit that reflects present-day feasibility of groundwater abstraction, we estimate that in 2050 groundwater becomes unattainable for 20% of the global population, mainly in the developing countries and pumping cost will increase significantly. Largest impacts are found

  1. Limit laws for exponential families

    OpenAIRE

    Balkema, August A.; Klüppelberg, Claudia; Resnick, Sidney I.

    1999-01-01

    For a real random variable [math] with distribution function [math] , define ¶ [math] ¶ The distribution [math] generates a natural exponential family of distribution functions [math] , where ¶ [math] ¶ We study the asymptotic behaviour of the distribution functions [math] as [math] increases to [math] . If [math] then [math] pointwise on [math] . It may still be possible to obtain a non-degenerate weak limit law [math] by choosing suitable scaling and centring constants [math] an...

  2. Protection limits on free speech

    Institute of Scientific and Technical Information of China (English)

    李敏

    2014-01-01

    Freedom of speech is one of the basic rights of citizens should receive broad protection, but in the real context of China under what kind of speech can be protected and be restricted, how to grasp between state power and free speech limit is a question worth considering. People tend to ignore the freedom of speech and its function, so that some of the rhetoric cannot be demonstrated in the open debates.

  3. Application of fault current limiters

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, A.

    2007-11-30

    This report presents the results of a study commissioned by the Department for Business, Enterprise and Industry (BERR; formerly the Department of Trade and Industry) into the application of fault current limiters in the UK. The study reviewed the current state of fault current limiter (FCL) technology and regulatory position in relation to all types of current limiters. It identified significant research and development work with respect to medium voltage FCLs and a move to high voltage. Appropriate FCL technologies being developed include: solid state breakers; superconducting FCLs (including superconducting transformers); magnetic FCLs; and active network controllers. Commercialisation of these products depends on successful field tests and experience, plus material development in the case of high temperature superconducting FCL technologies. The report describes FCL techniques, the current state of FCL technologies, practical applications and future outlook for FCL technologies, distribution fault level analysis and an outline methodology for assessing the materiality of the fault level problem. A roadmap is presented that provides an 'action agenda' to advance the fault level issues associated with low carbon networks.

  4. Scaling Limits of Graphene Nanoelectrodes.

    Science.gov (United States)

    Sarwat, Syed Ghazi; Gehring, Pascal; Rodriguez Hernandez, Gerardo; Warner, Jamie H; Briggs, G Andrew D; Mol, Jan A; Bhaskaran, Harish

    2017-06-14

    Graphene nanogap electrodes have been of recent interest in a variety of fields, ranging from molecular electronics to phase change memories. Several recent reports have highlighted that scaling graphene nanogaps to even smaller sizes is a promising route to more efficient and robust molecular and memory devices. Despite the significant interest, the operating and scaling limits of these electrodes are completely unknown. In this paper, we report on our observations of consistent voltage driven resistance switching in sub-5 nm graphene nanogaps. We find that such electrical switching from an insulating state to a conductive state occurs at very low currents and voltages (0.06 μA and 140 mV), independent of the conditions (room ambient, low temperatures, as well as in vacuum), thus portending potential limits to scaling of functional devices with carbon electrodes. We then associate this phenomenon to the formation and rupture of carbon chains. Using a phase change material in the nanogap as a demonstrator device, fabricated using a self-alignment technique, we show that for gap sizes approaching 1 nm the switching is dominated by such carbon chain formation, creating a fundamental scaling limit for potential devices. These findings have important implications, not only for fundamental science, but also in terms of potential applications.

  5. Limit cycle behaviour in FELIX

    Science.gov (United States)

    Jaroszynski, D. A.; Bakker, R. J.; Oepts, D.; van der Meer, A. F. G.; van Amersfoort, P. W.

    1993-07-01

    The free electron laser for infrared experiments (FELIX) operates at wavelengths up to λ = 110 μm. A radio-frequency linear accelerator is used to produce electron micropulses with a duration of about 3 ps. With N = 38 undulator periods, this puts FELIX well into the regime where the slippage length, Nλ, exceeds the electron micropulse length, and prominent short pulse effects are expected. One of these effects, stable limit cycle oscillations of the pulse energy, has not been detected experimentally before. Such oscillations occur when the saturated optical pulses move away from the electron pulses, due to the changing balance between lethargy and desynchronism, while new subpulses grow periodically. In FELIX, limit cycle behaviour is clearly demonstrated. The observations are in agreement with numerical simulations of the pulse propagation, and the oscillation period is given by a simple formula containing the slippage length and the desynchronism between optical and electron pulses. We also show how lethargic behaviour can be used to reduce the optical bandwidth of the FEL and to store optical energy in the optical cavity without saturation limiting the energy stored.

  6. Pure Phase Solubility Limits: LANL

    Energy Technology Data Exchange (ETDEWEB)

    C. Stockman

    2001-01-26

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO{sub 2} partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility

  7. Limits to Global Groundwater Consumption

    Science.gov (United States)

    Graaf, I. D.; Van Beek, R.; Sutanudjaja, E.; Wada, Y.; Bierkens, M. F.

    2015-12-01

    In regions with frequent water stress and large aquifer systems, groundwater is often used as an additional fresh water source. For many regions of the world groundwater abstraction exceeds groundwater recharge and persistent groundwater depletion occurs. The most direct effect of groundwater depletion is declining of water tables, leading to reduced groundwater discharge needed to sustain base-flow to e.g. rivers. Next to that, pumping costs increase, wells dry up and land subsidence occurs. These problems are expected to increase in the near future due to growing population and climate changes. This poses the urgent question of what the limits are of groundwater consumption worldwide. We simulate global water availability (5 arc-minute resolution, for 1960-2050) using the hydrological model PCR-GLOBWB (van Beek et al. 2011), coupled to a groundwater model based on MODFLOW (de Graaf et al. 2015), allowing for groundwater - surface water interactions. The groundwater model includes a parameterization of world's confined and unconfined aquifer systems needed for a realistic simulation of groundwater head dynamics. Water demands are included (from Wada et al. 2014). We study the limits to water consumption, focusing on locally attainable groundwater and groundwater levels critical to rivers to sustain low flows. We show an increasing trend (1960-2050) in groundwater head declines, due to increase in groundwater demand. Also, stream flow will decrease and low flow conditions will occur more frequent and will be longer in duration in the near future, especially for irrigated areas. Next to that, we provide a global overview of the years it takes until groundwater gets unattainable for e.g. a local farmer (100 m below land-surface used as a proxy), and estimate the increase in pumping cost for the near future. The results show where and when limits of groundwater consumption are reached globally.

  8. Limits to the growth debate

    Energy Technology Data Exchange (ETDEWEB)

    Gordon, L.

    The first two major studies sponsored by the club of Rome were the report of the Meadows team at MIT, The Limits to Growth, published in 1972, and the Mesarovic and Pestel report, Mankind at the Turning Point, published in 1974. When the Club of Rome met in Philadelphia in April of 1976, its pronouncements reflected a frame of mind quite different from that of 1972. Recently, Herman Kahn and his colleagues at the Hudson Institute have published The Next 200 Years, a book evidently inspired as much by antagonism to the limits-to-growth school of thought as by affirmative faith in its own vision of technological optimism. The author discusses the content of the studies and summarizes his own position in four areas. (1) While no trend of growth of anything can continue indefinitely in the real world, there are not global physical limits to economic growth within a time frame susceptible to plausible foresight or relevant to policy making. (2) In some world regions, notably South Asia and tropical Africa, population growth rates do indeed threaten to create a kind of Malthusian trap, and the rapid reduction of fertility is critically important to their development prospects and urgent in time. (3) For other parts of the world, both rates and directions of growth will be more influenced by changes in preferences for consumption and in attitudes toward production than by physical constraints, although higher energy costs and environmental pressures will also be important influences in generating such changes in growth patterns. (4) Probable changes in directions of growth will generate new and important issues in international economic and political relations, with both dangers and opportunities for the evolving world order. (MCW)

  9. Combination trading with limit orders

    Directory of Open Access Journals (Sweden)

    Henry Schellhorn

    1997-01-01

    Full Text Available We model the exchange of commodities that are contingent upon each other, when traders place mostly limit orders. Examples include: 1 a market of financial futures where future spreads are also traded, 2 a market of mutual funds and stocks, 3 a market of options and stocks, under the viewpoint that they are both combinations of Arrow-Debreu securities. We prove that consistent prices are optimal. We develop a fixed-point algorithm to compute an optimal price and allocation. The algorithm combines ideas from contraction mapping theory and from homotopy theory. It is much faster than a traditional linear programming approach.

  10. LIMITED RESTAURANT SERVICE: EASTER WEEKEND

    CERN Multimedia

    2003-01-01

    As Friday, April 18 and Monday, April 21, 2003 are CERN holidays, restaurants no. 1 (COOP : Bldg. 501- Meyrin) and no. 3 (AVENANCE : Bldg. 866 - Prévessin) will be closed and will remain so on Saturday and Sunday, April 19 - 20. They will reopen on Tuesday, April 22 at 7h00. During these four days, a limited service will be provided by restaurant no. 2 (DSR : Bldg. 504 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30.

  11. Limited Attention and Discourse Structure

    CERN Document Server

    Walker, M A

    1995-01-01

    This squib examines the role of limited attention in a theory of discourse structure and proposes a model of attentional state that relates current hierarchical theories of discourse structure to empirical evidence about human discourse processing capabilities. First, I present examples that are not predicted by Grosz and Sidner's stack model of attentional state. Then I consider an alternative model of attentional state, the cache model, which accounts for the examples, and which makes particular processing predictions. Finally I suggest a number of ways that future research could distinguish the predictions of the cache model and the stack model.

  12. Heisenberg limit superradiant superresolving metrology.

    Science.gov (United States)

    Wang, Da-Wei; Scully, Marlan O

    2014-08-22

    We propose a superradiant metrology technique to achieve the Heisenberg limit superresolving displacement measurement by encoding multiple light momenta into a three-level atomic ensemble. We use 2N coherent pulses to prepare a single excitation superradiant state in a superposition of two timed Dicke states that are 4N light momenta apart in momentum space. The phase difference between these two states induced by a uniform displacement of the atomic ensemble has 1/4N sensitivity. Experiments are proposed in crystals and in ultracold atoms.

  13. CSS3 pushing the limits

    CERN Document Server

    Greig, Stephen

    2013-01-01

    Push CSS3 and your design skills to the limit-and beyond! Representing an evolutionary leap forward for CSS, CSS3 is chock-full of new capabilities that dramatically expand the boundaries of what a styling language can do. But many of those new features remain undocumented, making it difficult to learn what they are and how to use them to create the sophisticated sites and web apps clients demand and users have grown to expect. Until now. This book introduces you to all of CSS3's new and advanced features, and, with the help of dozens of real-world examples and live

  14. Modern Cosmology: Assumptions and Limits

    Science.gov (United States)

    Hwang, Jai-Chan

    2012-06-01

    Physical cosmology tries to understand the Universe at large with its origin and evolution. Observational and experimental situations in cosmology do not allow us to proceed purely based on the empirical means. We examine in which sense our cosmological assumptions in fact have shaped our current cosmological worldview with consequent inevitable limits. Cosmology, as other branches of science and knowledge, is a construct of human imagination reflecting the popular belief system of the era. The question at issue deserves further philosophic discussions. In Whitehead's words, ``philosophy, in one of its functions, is the critic of cosmologies.'' (Whitehead 1925).

  15. Limited Regulation of Lake Erie.

    Science.gov (United States)

    1983-11-01

    Ontario,, Cedar Point in Ohio, Presque Isle in Pennsylvania and Hamlin in New York. Recreational boating is a significant activity on Lake Erie . Along...RD-Al47 936 LIMITED REGULATION OF LAKE ERIE (U) INTERNATIONAL LAKE i/i ERIE REGULATION STUDY BOARD NOV 83 UNCLASSIFIED F/G 13/2 N lhhhhh..hEmhhI...o lake Erie ’Governmen of 4,- % * L CTE " 84100400 .- Canad Unite Stte INTRNAIONL OIN COMISIO 4WD’ This document hais been ow for public rleoe and so

  16. On noise limited cellular networks

    CERN Document Server

    Decreusefond, Laurent; Vu, Thanh-Tung

    2010-01-01

    This paper introduces a general theoretical framework to analyze noise limited networks. More precisely, we consider two homogenous Poisson point processes of base stations and users. General model of radio signal propagation and effect of fading are also considered. The main difference of our model with respect to other existing models is that a user connects to his best servers but not necessarily the closest one. We provide general formula for the outage probability. We study functionals related to the SNR as well as the sum of these functionals over all users per cell. For the latter, the expectation and bounds on the variance are obtained.

  17. The Limit of Large Vessels

    Institute of Scientific and Technical Information of China (English)

    Yang Peiju

    2011-01-01

    On Feb 21(st),the industry was shocked by the news that AP Moller-Maersk placed an order of 10 container ships of 18,000 TEU with the South Korean ship yards.The order brings the development of large vessels to a new climax and at the same time puts forward a series of research subjects to the industry,such as what is the limit for the development of large vessels,whether ship safety can be guaranteed,and etc.

  18. Inverting the central limit theorem

    CERN Document Server

    Navascues, Miguel; Villanueva, Ignacio

    2011-01-01

    The central limit theorem states that the sum of N independently distributed n-tuples of real variables (subject to appropriate normalization) tends to a multivariate gaussian distribution for large N. Here we propose to invert this argument: given a set of n correlated gaussian variables, we try to infer information about the structure of the discrete microscopic probability distributions whose convolution generated such a macroscopic behavior. The techniques developed along the article are applied to prove that the classical description of certain macroscopic optical experiments is infinitely more complex than the quantum one.

  19. Modern Cosmology: Assumptions and Limits

    CERN Document Server

    Hwang, Jai-chan

    2012-01-01

    Physical cosmology tries to understand the Universe at large with its origin and evolution. Observational and experimental situations in cosmology do not allow us to proceed purely based on the empirical means. We examine in which sense our cosmological assumptions in fact have shaped our current cosmological worldview with consequent inevitable limits. Cosmology, as other branches of science and knowledge, is a construct of human imagination reflecting the popular belief system of the era. The question at issue deserves further philosophic discussions. In Whitehead's words, "philosophy, in one of its functions, is the critic of cosmologies". (Whitehead 1925)

  20. Nanofabrication principles, capabilities and limits

    CERN Document Server

    Cui, Zheng

    2017-01-01

    This second edition of Nanofabrication is one of the most comprehensive introductions on nanofabrication technologies and processes. A practical guide and reference, this book introduces readers to all of the developed technologies that are capable of making structures below 100nm. The principle of each technology is introduced and illustrated with minimum mathematics involved. Also analyzed are the capabilities of each technology in making sub-100nm structures, and the limits of preventing a technology from going further down the dimensional scale. This book provides readers with a toolkit that will help with any of their nanofabrication challenges.

  1. The Limits of CD Metrology

    Science.gov (United States)

    Rice, Bryan J.; Cao, Heidi; Grumski, Michael; Roberts, Jeanette

    2005-09-01

    One of the many technology decisions facing the semiconductor industry for the 32 nm node (and beyond) is the selection of the best critical dimension (CD) metrology equipment to meet the needs of process equipment suppliers and semiconductor manufacturers. Over the past three years Intel ® has fabricated a variety of test structures and performed a number of technology evaluations aimed at determining the limits of today's CD metrology. In this paper we discuss the capability of those technologies to measure structures having dimensions representative of the 45 nm, 32 nm, and 22 nm nodes.

  2. Controlling chaos with simple limiters

    Science.gov (United States)

    Corron; Pethel; Hopper

    2000-04-24

    New experimental results demonstrate that chaos control can be accomplished using controllers that are very simple relative to the system being controlled. Chaotic dynamics in a driven pendulum and a double scroll circuit are controlled using an adjustable, passive limiter-a weight for the pendulum and a diode for the circuit. For both experiments, multiple unstable periodic orbits are selectively controlled using minimal perturbations. These physical examples suggest that chaos control can be practically applied to a much wider array of important problems than initially thought possible.

  3. The limits of human performance.

    Science.gov (United States)

    Beneke, Ralph; Böning, Dieter

    2008-01-01

    Human performance, defined by mechanical resistance and distance per time, includes human, task and environmental factors, all interrelated. It requires metabolic energy provided by anaerobic and aerobic metabolic energy sources. These sources have specific limitations in the capacity and rate to provide re-phosphorylation energy, which determines individual ratios of aerobic and anaerobic metabolic power and their sustainability. In healthy athletes, limits to provide and utilize metabolic energy are multifactorial, carefully matched and include a safety margin imposed in order to protect the integrity of the human organism under maximal effort. Perception of afferent input associated with effort leads to conscious or unconscious decisions to modulate or terminate performance; however, the underlying mechanisms of cerebral control are not fully understood. The idea to move borders of performance with the help of biochemicals is two millennia old. Biochemical findings resulted in highly effective substances widely used to increase performance in daily life, during preparation for sport events and during competition, but many of them must be considered as doping and therefore illegal. Supplements and food have ergogenic potential; however, numerous concepts are controversially discussed with respect to legality and particularly evidence in terms of usefulness and risks. The effect of evidence-based nutritional strategies on adaptations in terms of gene and protein expression that occur in skeletal muscle during and after exercise training sessions is widely unknown. Biochemical research is essential for better understanding of the basic mechanisms causing fatigue and the regulation of the dynamic adaptation to physical and mental training.

  4. Limiting factors of starch hydrolysis.

    Science.gov (United States)

    Colonna, P; Leloup, V; Buléon, A

    1992-10-01

    Foods appear as complex structures, in which starch may be present in different forms. These, including the molecular characteristics and the crystalline organization, depend on processing conditions and compositions of ingredients. The main changes in starch macro- and microstructures are the increase of surface area to volume ratio in the solid phase, the modification of the crystallinity as affected by gelatinization and gelation, and the depolymerization of amylose and amylopectin. Starch modification may be estimated by different methodologies, which should be selected according to the level of structure considered. When amylose and amylopectin are in solution, rapid and total hydrolysis leads to the formation of a mixture of linear oligosaccharides and branched alpha-limit dextrins. However, starch usually occurs in foods as solid structures. Structural factors of starchy materials influence their enzymic hydrolysis. A better understanding of the enzymatic process enables the identification of the structural factors limiting hydrolysis: diffusion of enzyme molecules, porosity of solid substrates, adsorption of enzymes onto solid substrates, and the catalytic event. A mechanistic modelling should be possible in the future.

  5. DC superconducting fault current limiter

    Science.gov (United States)

    Tixador, P.; Villard, C.; Cointe, Y.

    2006-03-01

    There is a lack of satisfying solutions for fault currents using conventional technologies, especially in DC networks, where a superconducting fault current limiter could play a very important part. DC networks bring a lot of advantages when compared to traditional AC ones, in particular within the context of the liberalization of the electric market. Under normal operation in a DC network, the losses in the superconducting element are nearly zero and only a small, i.e. a low cost, refrigeration system is then required. The absence of zero crossing of a DC fault current favourably accelerates the normal zone propagation. The very high current slope at the time of the short circuit in a DC grid is another favourable parameter. The material used for the experiments is YBCO deposited on Al2O3 as well as YBCO coated conductors. The DC limitation experiments are compared to AC ones at different frequencies (50-2000 Hz). Careful attention is paid to the quench homogenization, which is one of the key issues for an SC FCL. The University of Geneva has proposed constrictions. We have investigated an operating temperature higher than 77 K. As for YBCO bulk, an operation closer to the critical temperature brings a highly improved homogeneity in the electric field development. The material can then absorb large energies without degradation. We present tests at various temperatures. These promising results are to be confirmed over long lengths.

  6. Performance limits of heliostat fields

    Energy Technology Data Exchange (ETDEWEB)

    Kribus, A.; Krupkin, V.; Yogev, A. [Weizmann Inst. of Science, Rehovot (Israel). Environmental Sciences and Energy Research Dept.; Spirkl, W. [Ludwig-Maximilians-Univ. Muenchen (Germany). Sektion Physik

    1998-11-01

    Geometric and thermodynamic arguments are used to derive upper limits on the performance of a solar energy collection system, consisting of an axisymmetric heliostat field, a solar tower, secondary optics and a black receiver. Performance limits on collected power, concentration, and work output are presented. Performance of tower systems with several secondary optics options is compared: tower-top Compound Parabolic Concentrator (CPC), Tailored Edge-Ray Concentrator (TERC) approximated by a cone, and Cassegrainian with ground-level CPC or Compound Elliptic Concentrator (CEC). Optimized ray tracing is used to generate the design parameters of the secondary concentrators that yield the highest optical efficiency. The results show that the tower-top Cone provides the best performance regarding both concentration and efficiency, except for very large fields. The Cassegrainian designs come in second, but become equal and even better than the Cone for large fields. The results for the Cassegrainian are sensitive to the value of the reflectivity, due to the additional reflections incurred. The choice of a CEC is better than a CPC for the terminal concentration in a Cassegrainian system, but the difference is small. The suitability of the different design options for high-temperature solar applications is discussed. The recommendations regarding optical configuration depend on field size, as well as on application-specific constraints.

  7. Measurement limits in flash thermography

    Science.gov (United States)

    Shepard, Steven M.; Lhota, James R.; Ahmed, Tasdiq

    2009-05-01

    Although active thermography has traditionally been regarded as a qualitative NDT method, its potential for quantitative measurement of thermophysical properties including wall thickness, flaw size and depth, thermal diffusivity or effusivity has been the subject of numerous investigations. Enabled by improvements in IR camera technology and fast, abundant and inexpensive computing power for advanced signal processing, measurement results have been reported using a variety of excitation and signal processing schemes. Results are often presented as a correlation between thermography data and nominal properties or independent measurements by another "validated" method. However, given the diffusion mechanism that underlies thermography, and the quantization and sampling conditions implicit in using an IR camera as a temperature sensor, there are definite limits to what can be achieved in a thermography measurement. While many benefits can be achieved with improved instrumentation, efficient energy insertion or optimized signal processing, ultimately, the limits imposed by diffusion and instrumentation take precedence, and cannot be circumvented. In this paper, the effects of camera frame rate and sensitivity on measurement of the thickness of a slab are examined, using basic 1-dimensional diffusion approximations.

  8. Energy-limited escape revised

    CERN Document Server

    Salz, M; Czesla, S; Schmitt, J H M M

    2016-01-01

    Gas planets in close proximity to their host stars experience photoevaporative mass loss. The energy-limited escape concept is generally used to derive estimates for the planetary mass-loss rates. Our photoionization hydrodynamics simulations of the thermospheres of hot gas planets show that the energy-limited escape concept is valid only for planets with a gravitational potential lower than $\\log_\\mathrm{10}\\left( -\\Phi_{\\mathrm{G}}\\right) < 13.11~$erg$\\,$g$^{-1}$ because in these planets the radiative energy input is efficiently used to drive the planetary wind. Massive and compact planets with $\\log_\\mathrm{10}\\left( -\\Phi_{\\mathrm{G}}\\right) \\gtrsim 13.6~$erg$\\,$g$^{-1}$ exhibit more tightly bound atmospheres in which the complete radiative energy input is re-emitted through hydrogen Ly$\\alpha$ and free-free emission. These planets therefore host hydrodynamically stable thermospheres. Between these two extremes the strength of the planetary winds rapidly declines as a result of a decreasing heating eff...

  9. 40 CFR 158.350 - Certified limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Certified limits. 158.350 Section 158... REQUIREMENTS FOR PESTICIDES Product Chemistry § 158.350 Certified limits. The applicant must propose certified limits for the ingredients in the product. Certified limits become legally binding limits upon...

  10. 36 CFR 4.21 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Speed limits. 4.21 Section 4... TRAFFIC SAFETY § 4.21 Speed limits. (a) Park area speed limits are as follows: (1) 15 miles per hour... superintendent may designate a different speed limit upon any park road when a speed limit set forth in...

  11. 50 CFR 622.37 - Size limits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Size limits. 622.37 Section 622.37... limits. All size limits in this section are minimum size limits unless specified otherwise. Except for... compliance with its size limit, as specified in this section, in or from the Caribbean, Gulf, South...

  12. Homogeneity and plane-wave limits

    CERN Document Server

    Figueroa-O'Farrill, J M; Philip, S; Farrill, Jos\\'e Figueroa-O'; Meessen, Patrick; Philip, Simon

    2005-01-01

    We explore the plane-wave limit of homogeneous spacetimes. For plane-wave limits along homogeneous geodesics the limit is known to be homogeneous and we exhibit the limiting metric in terms of Lie algebraic data. This simplifies many calculations and we illustrate this with several examples. We also investigate the behaviour of (reductive) homogeneous structures under the plane-wave limit.

  13. Quantum parallelism may be limited

    CERN Document Server

    Ozhigov, Yu I

    2016-01-01

    We consider quantum formalism limited by the classical simulating computer with the fixed memory. The memory is redistributed in the course of modeling by the variation of the set of classical states and the accuracy of the representation of amplitudes. This computational description completely preserves the conventional formalism and does not contradicts to experiments, but it makes impossible fast quantum algorithms. This description involves the slow down of quantum evolutions with the growth of the dimension of the minimal subspace containing entangled states, which arise in the evolution. This slow down is the single difference of the proposed formalism from the standard one; it is negligible for the systems from the usual experiments, including those in which many entangled particle participate, but grows rapidly in the attempt to realize the scalable quantum computations, which require the unlimited parallelism. The experimental verification of this version of quantum formalism is reduced to the fixati...

  14. THE LIMITS OF ESP TESTS

    Directory of Open Access Journals (Sweden)

    Norica-Felicia BUCUR

    2015-07-01

    Full Text Available Global market forces have determined not only higher education institutions all over the world to include ESP courses in their curriculum to enhance their students’ future employability, but also public and private organisations to offer their employees the opportunity to attend ESP courses in order to meet the continuously growing ESP needs. From this perspective, ESP compentence could become a subcomponent of one of the key competences for lifelong learning, communication in foreign languages. Therefore assessing ESP competence seems to acquire paramount importance since stakeholders need accurate information about the ESP learners’ abilities to cope with specific language tasks. This article offers a concise overview of the principles and practices of ESP assessment, a detailed description of the features of ESP tests, while focusing particularly on the limits of ESP tests in order to identify possible solutions to overcome them.

  15. Mathematical methods for hydrodynamic limits

    CERN Document Server

    Masi, Anna

    1991-01-01

    Entropy inequalities, correlation functions, couplings between stochastic processes are powerful techniques which have been extensively used to give arigorous foundation to the theory of complex, many component systems and to its many applications in a variety of fields as physics, biology, population dynamics, economics, ... The purpose of the book is to make theseand other mathematical methods accessible to readers with a limited background in probability and physics by examining in detail a few models where the techniques emerge clearly, while extra difficulties arekept to a minimum. Lanford's method and its extension to the hierarchy of equations for the truncated correlation functions, the v-functions, are presented and applied to prove the validity of macroscopic equations forstochastic particle systems which are perturbations of the independent and of the symmetric simple exclusion processes. Entropy inequalities are discussed in the frame of the Guo-Papanicolaou-Varadhan technique and of theKipnis-Oll...

  16. The Limits of Custodial Symmetry

    CERN Document Server

    Chivukula, R Sekhar; Foadi, Roshan; Simmons, Elizabeth H

    2010-01-01

    We introduce a toy model implementing the proposal of using a custodial symmetry to protect the Z b_L bbar_L coupling from large corrections. This "doublet-extended standard model" adds a weak doublet of fermions (including a heavy partner of the top quark) to the particle content of the standard model in order to implement an O(4) x U(1)_X = SU(2)_L x SU(2)_R x P_LR x U(1)_X symmetry in the top-quark mass generating sector. This symmetry is softly broken to the gauged SU(2)_L x U(1)_Y electroweak symmetry by a Dirac mass M for the new doublet; adjusting the value of M allows us to explore the range of possibilities between the O(4)-symmetric (M to 0) and standard-model-like (M to infinity) limits.

  17. The Limits of Custodial Symmetry

    CERN Document Server

    Chivukula, R Sekhar; Foadi, Roshan; Simmons, Elizabeth H

    2010-01-01

    We introduce a toy model implementing the proposal of using a custodial symmetry to protect the Zbb coupling from large corrections. This "doublet-extended standard model" adds a weak doublet of fermions (including a heavy partner of the top quark) to the particle content of the standard model in order to implement an O(4) x U(1)_X = SU(2)_L x SU(2)_R x P_{LR} x U(1)_X symmetry that protects the Zbb coupling. This symmetry is softly broken to the gauged SU(2)_L x U(1)_Y electroweak symmetry by a Dirac mass M for the new doublet; adjusting the value of M allows us to explore the range of possibilities between the O(4)-symmetric (M to 0) and standard-model-like (M to infinity) limits.

  18. LIMITED RESTAURANT SERVICE 'JEUNE GENEVOIS'

    CERN Multimedia

    2000-01-01

    On Thursday, September 7, 2000, all restaurants, cafétérias and kiosques will be closed except for restaurant no. 1 and its cafétéria (COOP - building 501 - Meyrin) which will provide a limited service from 8h00 to 21h00. Hot meals will be served from 11h30 to 14h00 and from 18h00 to 19h30. For technical reasons, restaurant no. 2 and its cafétéria (DSR - building 504 - Meyrin) will remain closed on Friday, September 8. They will resume their normal activities on Monday, September 11, 2000. The other restaurants, cafétérias and kiosques will offer their normal service as from Friday, September 8.

  19. LIMITED RESTAURANT SERVICE : EASTER WEEKEND

    CERN Multimedia

    Restaurant Supervisory Committee

    2002-01-01

    As Friday, March 29 and Monday, April 1st, 2002 are CERN holidays, restaurants no. 1 (COOP : Bldg. 501- Meyrin) and no. 3 (Avenance : Bldg. 866 - Prévessin) will be closed and will remain so on Saturday and Sunday, March 30 - 31. They will reopen on Tuesday, April 2 at 7h00. During these four days, a limited service will be provided by restaurant no. 2 (DSR : Bldg. 504 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. On Thursday, March 28, all three restaurants will operate according to the usual times except for restaurant no. 1 which will close at 21h00 instead of 1 o'clock in the morning.   Restaurant Supervisory Committee, tel. 77551

  20. LIMITED RESTAURANT SERVICE : EASTER WEEKEND

    CERN Multimedia

    Restaurant Supervisory Committee

    2002-01-01

    As Friday 29 March and Monday 1st April 2002 are CERN holidays, restaurants no. 1 (COOP, bldg. 501- Meyrin) and no. 3 (Avenance, bldg. 866 - Prévessin) will be closed and will remain so on Saturday and Sunday 30-31 March. They will reopen on Tuesday 2 April at 7h00. During these four days, a limited service will be provided by restaurant no. 2 (DSR, bldg. 504 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. On Thursday 28 March, all three restaurants will operate according to the usual times except for restaurant no. 1 which will close at 21h00 instead of 1 o'clock in the morning. Restaurant Supervisory Committee Tel. 77551

  1. LIMITED RESTAURANT SERVICE : EASTER WEEKEND

    CERN Multimedia

    2003-01-01

    As Friday, April 18 and Monday, April 21, 2003 are CERN holidays, restaurants no. 1 (COOP : Bldg. 501- Meyrin) and no. 3 (AVENANCE : Bldg. 866 - Prévessin) will be closed and will remain so on Saturday and Sunday, April 19 - 20. They will reopen on Tuesday, April 22 at 7h00. During these four days, a limited service will be provided by restaurant no. 2 (DSR : Bldg. 504 - Meyrin) from 8h00 to 21h00 with hot meals served from 11h30 to 14h00 and from 18h00 to 19h30. On Thursday, April 17, all three restaurants will operate according to the usual times except for restaurant no. 1 which will close at 21h00 instead of 1 o'clock in the morning.

  2. The limits of Muscovite autocracy

    OpenAIRE

    Soldat, Cornelia

    2005-01-01

    Les limites de l’autocratie moscovite. Les relations entre le grand-prince et les bojare vues à travers l’œuvre de Josif Volockij, Prosvetitel´.– Depuis que Sigismund Herberstein a affirmé que le tsar moscovite régnait en « maître », donc en « tyran », sur ses sujets, qui se désignaient eux-mêmes comme ses « esclaves » (holopy), l’historiographie occidentale ne manque pas de décrire la relation entre le tsar et ses bojare comme patriarcale et empreinte de cruauté. L’auteur de l’article soutie...

  3. Certifying Equality With Limited Interaction

    DEFF Research Database (Denmark)

    Brody, Joshua Eric; Chakrabarti, Amit; McGregor, Andrew;

    2012-01-01

    The \\textsc{equality} problem is usually one's first encounter with communication complexity and is one of the most fundamental problems in the field. Although its deterministic and randomized communication complexity were settled decades ago, we find several new things to say about the problem...... by focusing on two subtle aspects. The first is to consider the {\\em expected} communication cost (at a worst-case input) for a protocol that uses limited interaction---i.e., a bounded number of rounds of communication---and whose error probability is zero or close to it. The second is to consider the {\\em...... cost bounds, we obtain new bounded-round randomized lower bounds for the \\textsc{or-equality} problem that have a direct-sum flavor. Such lower bounds were previously known only for deterministic protocols or one-round randomized protocols. The \\textsc{or-equality} problem is in turn closely related...

  4. Pericytes limit tumor cell metastasis

    DEFF Research Database (Denmark)

    Xian, Xiaojie; Håkansson, Joakim; Ståhlberg, Anders

    2006-01-01

    Previously we observed that neural cell adhesion molecule (NCAM) deficiency in beta tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient beta cell tumors grew leaky blood vessels with perturbed pericyte-endothelial cell-cell interactions...... and deficient perivascular deposition of ECM components. Conversely, tumor cell expression of NCAM in a fibrosarcoma model (T241) improved pericyte recruitment and increased perivascular deposition of ECM molecules. Together, these findings suggest that NCAM may limit tumor cell metastasis by stabilizing...... the microvessel wall. To directly address whether pericyte dysfunction increases the metastatic potential of solid tumors, we studied beta cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice. This resulted in beta tumor cell metastases in distant organs and local lymph nodes, demonstrating a role...

  5. The limits of filopodium stability

    CERN Document Server

    Pronk, Sander; Fletcher, Daniel A

    2008-01-01

    Filopodia are long, finger-like membrane tubes supported by cytoskeletal filaments. Their shape is determined by the stiffness of the actin filament bundles found inside them and by the interplay between the surface tension and bending rigidity of the membrane. Although one might expect the Euler buckling instability to limit the length of filopodia, we show through simple energetic considerations that this is in general not the case. By further analyzing the statics of filaments inside membrane tubes, and through computer simulations that capture membrane and filament fluctuations, we show under which conditions filopodia of arbitrary lengths are stable. We discuss several in vitro experiments where this kind of stability has already been observed. Furthermore, we predict that the filaments in long, stable filopodia adopt a helical shape.

  6. Solving Limited Memory Influence Diagrams

    CERN Document Server

    Mauá, Denis Deratani; Zaffalon, Marco

    2011-01-01

    We present a new algorithm for exactly solving decision making problems represented as influence diagrams. We do not require the usual assumptions of no forgetting and regularity; this allows us to solve problems with simultaneous decisions and limited information. The algorithm is empirically shown to outperform a state-of-the-art algorithm on randomly generated problems of up to 150 variables and $10^{64}$ solutions. We show that the problem is NP-hard even if the underlying graph structure of the problem has small treewidth and the variables take on a bounded number of states, but that a fully polynomial time approximation scheme exists for these cases. Moreover, we show that the bound on the number of states is a necessary condition for any efficient approximation scheme.

  7. Prostatic carcinoma: limited field irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Rounsaville, M.C.; Green, J.P.; Vaeth, J.M.; Purdon, R.P.; Heltzel, M.M.

    1987-07-01

    This is a retrospective study of 251 patients with histologically proven adenocarcinoma treated primarily with limited field radiotherapy techniques, under the principle direction of authors JMV and JPG, between 1968 and 1981 in San Francisco, California. All patients are followed for a minimum of 3 years; mean follow-up is 7.3 years. Routine clinical staging procedures included: HandP, digital prostate exam, cystoscopy, biopsy, blood studies including serum acid phosphatase, and imaging studies including chest X ray, IVP, bone survey or radionucleotide bone scan, and in recent years, pelvic CT scans. Twelve patients are Stage A1, 37-Stage A2, 50-Stage B, 140-Stage C1 and 12-Stage C2. Ninety percent of all cases and 85% of Stage C patients were treated with limited fields to the prostate and periprostatic volume only. Total doses were prescribed at midplane or isocenter and were generally 6500-7000 cGy, daily doses of 180-200 cGy, 5 days per week. Actuarial 5- and 10-year survival rates are: entire population-69% and 47%; Stage A1-74% and 50%; Stage A2-81% and 67%; Stage B-84% and 53%; Stage C1-63% and 42%; Stage C2-32% and 11%. The 5- and 10-year disease-free actuarial survivals are: entire population-71% and 50%; Stage A1-89% and 74%; Stage A2-82% and 69%; Stage B-71% and 52%; Stage C1-67% and 44%; Stage C2-0%. Sites of recurrence, alone or as a component of the failure pattern are: 37 (15%) local, 11 (4%) symptomatic regional recurrence (lower extremity edema, pelvic pain/sciatica, hydroureteronephrosis), and 87 (35%) distant metastasis. Seven (3%) had unknown sites of failure. Local-regional failure occurred in 42% of Stage C2 patients.

  8. Prospective Optimization with Limited Resources.

    Science.gov (United States)

    Snider, Joseph; Lee, Dongpyo; Poizner, Howard; Gepshtein, Sergei

    2015-09-01

    The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their "depth of computation") and how often they attempted to incorporate new information about the future rewards (their "recalculation period"). We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation.

  9. Prospective Optimization with Limited Resources.

    Directory of Open Access Journals (Sweden)

    Joseph Snider

    2015-09-01

    Full Text Available The future is uncertain because some forthcoming events are unpredictable and also because our ability to foresee the myriad consequences of our own actions is limited. Here we studied how humans select actions under such extrinsic and intrinsic uncertainty, in view of an exponentially expanding number of prospects on a branching multivalued visual stimulus. A triangular grid of disks of different sizes scrolled down a touchscreen at a variable speed. The larger disks represented larger rewards. The task was to maximize the cumulative reward by touching one disk at a time in a rapid sequence, forming an upward path across the grid, while every step along the path constrained the part of the grid accessible in the future. This task captured some of the complexity of natural behavior in the risky and dynamic world, where ongoing decisions alter the landscape of future rewards. By comparing human behavior with behavior of ideal actors, we identified the strategies used by humans in terms of how far into the future they looked (their "depth of computation" and how often they attempted to incorporate new information about the future rewards (their "recalculation period". We found that, for a given task difficulty, humans traded off their depth of computation for the recalculation period. The form of this tradeoff was consistent with a complete, brute-force exploration of all possible paths up to a resource-limited finite depth. A step-by-step analysis of the human behavior revealed that participants took into account very fine distinctions between the future rewards and that they abstained from some simple heuristics in assessment of the alternative paths, such as seeking only the largest disks or avoiding the smaller disks. The participants preferred to reduce their depth of computation or increase the recalculation period rather than sacrifice the precision of computation.

  10. Pure Phase Solubility Limits: LANL

    Energy Technology Data Exchange (ETDEWEB)

    C. Stockman

    2001-01-26

    The natural and engineered system at Yucca Mountain (YM) defines the site-specific conditions under which one must determine to what extent the engineered and the natural geochemical barriers will prevent the release of radioactive material from the repository. Most important mechanisms for retention or enhancement of radionuclide transport include precipitation or co-precipitation of radionuclide-bearing solid phases (solubility limits), complexation in solution, sorption onto surfaces, colloid formation, and diffusion. There may be many scenarios that could affect the near-field environment, creating chemical conditions more aggressive than the conditions presented by the unperturbed system (such as pH changes beyond the range of 6 to 9 or significant changes in the ionic strength of infiltrated waters). For an extended period of time, the near-field water composition may be quite different and more extreme in pH, ionic strength, and CO{sub 2} partial pressure (or carbonate concentration) than waters at some distance from the repository. Reducing conditions, high pH (up to 11), and low carbonate concentration may be present in the near-field after reaction of infiltrating groundwater with engineered barrier systems, such as cementitious materials. In the far-field, conditions are controlled by the rock-mass buffer providing a near-neutral, oxidizing, low-ionic-strength environment that controls radionuclide solubility limits and sorption capacities. There is the need for characterization of variable chemical conditions that affect solubility, speciation, and sorption reactions. Modeling of the groundwater chemistry is required and leads to an understanding of solubility and speciation of the important radionuclides. Because experimental studies cannot be performed under the numerous potential chemical conditions, solubility limitations must rely on geochemical modeling of the radionuclide's chemistry. Fundamental thermodynamic properties, such as solubility

  11. 24 CFR 585.302 - Award limits.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Award limits. 585.302 Section 585... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Implementation Grants § 585.302 Award limits... than the specified limit....

  12. Bilepton and exotic quark mass limits in 331 models from $Z \\to b\\overline{b}$ decay

    CERN Document Server

    González-Sprinberg, G A; Sampayo, O

    2005-01-01

    We study the effect of new physics on the Z-decay into b anti-b pairs in the framework of 331 models. The decay Z -> b anti-b is computed at one loop level and, using previous results, we evaluate this branching fraction in the framework of 331 models. A wide range of the space parameter of the model is considered and possible deviations from the standard model predictions are explored. From precision measurements at the Z-pole we find the allowed region for MJ3, MX at 95 % CL.

  13. 50 CFR 660.232 - Limited entry daily trip limit (DTL) fishery for sablefish.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Limited entry daily trip limit (DTL... limit (DTL) fishery for sablefish. (a) Limited entry DTL fisheries both north and south of 36° N. lat... restrictions and limits of the limited entry daily and/or weekly trip limit (DTL) fishery for...

  14. IDENTIDADES MASCULINAS: LIMITES E POSSIBILIDADES

    Directory of Open Access Journals (Sweden)

    May-Lin Wang

    2006-06-01

    Full Text Available O presente trabalho toma por base uma abordagem psicossocial para discorrer sobre os limites impostos pelos estereótipos de gênero à construção de uma identidade masculina, em contraposição às possibilidades de subjetivação, num cenário cultural de pluralidade identitária. Ênfase é dada à socialização estereotipada dos meninos, num processo no qual se verifica uma espécie de superposição do contexto socio-histórico em que cresceram os pais àquele no qual o menino é socializado, acentuando determinadas crenças sobre gênero. O modelo tradicional de virilidade, que imperava inquestionável até bem pouco tempo, ignorando as necessidades afetivas e valorizando características como a competitividade, a preocupação com o desempenho, o autoritarismo, a dominação e a opressão, vem sendo questionado como pilar maior da identidade masculina tradicional.

  15. Exploring life's limits: Deep geobiochemistry

    Science.gov (United States)

    Cox, A. D.

    2014-12-01

    N-dimensional chemical space on Earth and beyond produces diverse habitats for microbial activity. Hydrothermal environments cover a wide range of habitable space up to and including life's known limits and provide a window into deep geological, geochemical, and biological processes. Hydrothermal water compositions, as sampled from and measured in terrestrial hot springs on Earth's surface, vary in chemical constituent speciation and concentrations over orders of magnitude in a plethora of geochemical parameters with biological significance, including hydronium ion, sulfide, iron, zinc, magnesium, manganese, and molybdenum. Proteins provide a link between geochemistry and microbial activity by catalyzing chemical reactions. Proteins extracted and identified by tandem mass spectrometry from 13 hot spring sediments and biofilms - covering pH values from 2-9 and diverse geochemical compositions - function as efflux transporters, permeases, electron transporters, and others, suggesting that these processes were present in the environment and occurring at the time of sampling. Metalloenzymes have been identified, including the iron protein rubrerythrin, thought to be involved in oxidative stress protection in anaerobic bacteria and archaea, as well as proteins involved in macronutrient processing (carbon, phosphorus, nitrogen, and sulfur). The melding of biochemistry with geochemistry shows potential for quantifying microbial activity in deep environments by demonstrating the presence - and as techniques improve, relative abundances - of reaction-catalyzing enzymes. Moreover, using hot spring sources and their outflow channels as chemical and biological models of geologic time helps decipher the origin and co-evolution of life and geochemistry.

  16. Limits to Drift Chamber Resolution

    CERN Document Server

    Riegler, Werner

    1998-01-01

    ATLAS (A Large Toroidal LHC Apparatus) will be a general-purpose experiment at the Large Hadron Collider that will be operational at CERN in the year 2004. The ATLAS muon spectrometer aims for a momentum resolution of 10% for a transverse momentum of pT=1TeV. The precision tracking devices in the muon system will be high pressure drift tubes (MDTs) with a single wire resolution of 1100 chambers covering an area of ≈ 2500m2. The high counting rates in the spectrometer as well as the aim for excellent spatial resolution and high efficiency put severe constraints on the MDT operating parameters. This work describes a detailed study of all the resolution limiting factors in the ATLAS environment. A ’full chain’ simulation of the MDT response to photons and charged particles as well as quantitative comparisons with measurements was performed. The good agreement between simulation and measurements resulted in a profound understanding of the drift chamber processes and the individual contributions to the spat...

  17. Shear wall ultimate drift limits

    Energy Technology Data Exchange (ETDEWEB)

    Duffey, T.A. [Duffy, (T.A.) Tijeras, NM (United States); Goldman, A. [Goldman, (A.), Sandia, Los Alamos, NM (United States); Farrar, C.R. [Los Alamos National Lab., NM (United States)

    1994-04-01

    Drift limits for reinforced-concrete shear walls are investigated by reviewing the open literature for appropriate experimental data. Drift values at ultimate are determined for walls with aspect ratios ranging up to a maximum of 3.53 and undergoing different types of lateral loading (cyclic static, monotonic static, and dynamic). Based on the geometry of actual nuclear power plant structures exclusive of containments and concerns regarding their response during seismic (i.e.,cyclic) loading, data are obtained from pertinent references for which the wall aspect ratio is less than or equal to approximately 1, and for which testing is cyclic in nature (typically displacement controlled). In particular, lateral deflections at ultimate load, and at points in the softening region beyond ultimate for which the load has dropped to 90, 80, 70, 60, and 50 percent of its ultimate value, are obtained and converted to drift information. The statistical nature of the data is also investigated. These data are shown to be lognormally distributed, and an analysis of variance is performed. The use of statistics to estimate Probability of Failure for a shear wall structure is illustrated.

  18. Agriculture: access to technology limited.

    Science.gov (United States)

    1997-01-01

    From country to country and even regionally, the roles of women in agriculture vary, but most of their labor is in unpaid subsistence production and their contributions tend to be underestimated, according to the results of the [UN] Secretary-General's report. Depending on circumstances, they have complementary roles with men, sharing or dividing tasks in the production of crops, care of animals, and forestry management. In sub-Saharan Africa, for example, women contribute 60-80% of labor in food production for both household consumption and sale, while in Malaysia the women account for only 35% of the agricultural labor force, and in Ireland the participation rate is only 10.4%. Although women make this important amount of labor contributions to agricultural production, "development policies tend to favor export crops to earn foreign exchange and the agricultural research tends to address the improvement of production and technologies for commercial production". This results in limited access for women to technical knowledge and innovations, including irrigation, machinery, farming techniques and extension services. This is strengthened by the fact that most of the extension services target farmers who own land and can obtain credit to invest in input and technology. full text

  19. Photon and graviton mass limits

    Energy Technology Data Exchange (ETDEWEB)

    Nieto, Michael [Los Alamos National Laboratory; Goldhaber Scharff, Alfred [SUNY

    2008-01-01

    We review past and current studies of possible long-distance, low-frequency deviations from Maxwell electrodynamics and Einstein gravity. Both have passed through three phases: (1) Testing the inverse-square laws of Newton and Coulomb, (2) Seeking a nonzero value for the rest mass of photon or graviton, and (3) Considering more degrees of freedom, allowing mass while preserving gauge or general-coordinate invariance. For electrodynamics there continues to be no sign of any deviation. Since our previous review the lower limit on the photon Compton wavelength (associated with weakening of electromagnetic fields in vacuum over large distance scale) has improved by four orders of magnitude, to about one astronomical unit. Rapid current progress in astronomical observations makes it likely that there will be further advances. These ultimately could yield a bound exceeding galactic dimensions, as has long been contemplated. Meanwhile, for gravity there have been strong arguments about even the concept of a graviton rest mass. At the same time there are striking observations, commonly labeled 'dark matter' and 'dark energy' that some argue imply modified gravity. This makes the questions for gravity much more interesting. For dark matter, which involves increased attraction at large distances, any explanation by modified gravity would be qualitatively different from graviton mass. Because dark energy is associated with reduced attraction at large distances, it might be explained by a graviton-mass-like effect.

  20. Fault current limiters using superconductors

    Science.gov (United States)

    Norris, W. T.; Power, A.

    Fault current limiters on power systems are to reduce damage by heating and electromechanical forces, to alleviate duty on switchgear used to clear the fault, and to mitigate disturbance to unfaulted parts of the system. A basic scheme involves a super-resistor which is a superconductor being driven to high resistance when fault current flows either when current is high during a cycle of a.c. or, if the temperature of the superconductive material rises, for the full cycle. Current may be commuted from superconductor to an impedance in parallel, thus reducing the energy dispersed at low temperature and saving refrigeration. In a super-shorted transformer the ambient temperature primary carries the power system current; the superconductive secondary goes to a resistive condition when excessive currents flow in the primary. A super-transformer has the advantage of not needing current leads from high temperature to low temperature; it behaves as a parallel super-resistor and inductor. The supertransductor with a superconductive d.c. bias winding is large and has small effect on the rate of fall of current at current zero; it does little to alleviate duty on switchgear but does reduce heating and electromechanical forces. It is fully active after a fault has been cleared. Other schemes depend on rapid recooling of the superconductor to achieve this.

  1. Glacial effects limiting mountain height.

    Science.gov (United States)

    Egholm, D L; Nielsen, S B; Pedersen, V K; Lesemann, J-E

    2009-08-13

    The height of mountain ranges reflects the balance between tectonic rock uplift, crustal strength and surface denudation. Tectonic deformation and surface denudation are interdependent, however, and feedback mechanisms-in particular, the potential link to climate-are subjects of intense debate. Spatial variations in fluvial denudation rate caused by precipitation gradients are known to provide first-order controls on mountain range width, crustal deformation rates and rock uplift. Moreover, limits to crustal strength are thought to constrain the maximum elevation of large continental plateaus, such as those in Tibet and the central Andes. There are indications that the general height of mountain ranges is also directly influenced by the extent of glaciation through an efficient denudation mechanism known as the glacial buzzsaw. Here we use a global analysis of topography and show that variations in maximum mountain height correlate closely with climate-controlled gradients in snowline altitude for many high mountain ranges across orogenic ages and tectonic styles. With the aid of a numerical model, we further demonstrate how a combination of erosional destruction of topography above the snowline by glacier-sliding and commensurate isostatic landscape uplift caused by erosional unloading can explain observations of maximum mountain height by driving elevations towards an altitude window just below the snowline. The model thereby self-consistently produces the hypsometric signature of the glacial buzzsaw, and suggests that differences in the height of mountain ranges mainly reflect variations in local climate rather than tectonic forces.

  2. 45 CFR 5.35 - Time limits.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Time limits. 5.35 Section 5.35 Public Welfare... Denial of Records § 5.35 Time limits. (a) General. FOIA sets certain time limits for us to decide whether... time limits, but if it appears that processing your request may take longer than we would wish, we...

  3. 5 CFR 2604.305 - Time limits.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Time limits. 2604.305 Section 2604.305... Disclosure of Records Under FOIA § 2604.305 Time limits. (a)(1) Initial request. Following receipt of a... appeal. (c) Extension of time limits. The time limits specified in either paragraph (a) or (b) of...

  4. 49 CFR 218.35 - Yard limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Yard limits. 218.35 Section 218.35 Transportation... TRANSPORTATION RAILROAD OPERATING PRACTICES Protection of Trains and Locomotives § 218.35 Yard limits. (a) After August 1, 1977, yard limits must be designated by— (1) Yard limit signs, and (2) Timetable, train...

  5. Tracial Limit of C*-algebras

    Institute of Scientific and Technical Information of China (English)

    Shan Wen HU; Hua Xin LIN; Yi Feng XUE

    2003-01-01

    A new limit of C*-algebras, the tracial limit, is introduced in this paper. We show thata separable simple C*-algebra 4 is a tracial limit of C*-algebras in Z(k) if and only if A has tracialtopological rank no more than k. We present several known results using the notion of tracial limits.

  6. 7 CFR 52.3185 - Moisture limits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Moisture limits. 52.3185 Section 52.3185 Agriculture... Moisture limits. Dried prunes shall not exceed the moisture limits for the applicable grades and kind and size of packaging as designated in Table IV of this subpart except there is no moisture limit when...

  7. 78 FR 57790 - Extension of Time Limits

    Science.gov (United States)

    2013-09-20

    ... International Trade Administration 19 CFR Part 351 RIN 0625-AA94 Extension of Time Limits AGENCY: Import... Department of Commerce (the Department) is modifying its regulation concerning the extension of time limits... clarifies that parties may request an extension of time limits before any time limit established under...

  8. 36 CFR 1004.21 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Speed limits. 1004.21 Section... limits. (a) Speed limits in the area administered by the Presidio Trust are as follows: (1) 15 miles per... Presidio Trust roads. (b) The Board may designate a different speed limit upon any Presidio Trust road...

  9. 45 CFR 1160.13 - Indemnification limits.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Indemnification limits. 1160.13 Section 1160.13... ACT § 1160.13 Indemnification limits. The dollar amounts of the limits described below are found in the guidelines referred to in § 1160.1 and are based upon the statutory limits in the Arts...

  10. 45 CFR 3.26 - Speed limit.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Speed limit. 3.26 Section 3.26 Public Welfare... INSTITUTES OF HEALTH FEDERAL ENCLAVE Traffic Regulations § 3.26 Speed limit. The speed limit is 25 miles per hour, unless otherwise posted. A driver of a vehicle may not exceed the speed limit....

  11. 50 CFR 20.24 - Daily limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Daily limit. 20.24 Section 20.24 Wildlife... (CONTINUED) MIGRATORY BIRD HUNTING Taking § 20.24 Daily limit. No person shall take in any 1 calendar day, more than the daily bag limit or aggregate daily bag limit, whichever applies....

  12. The role of limiter in Egyptor Tokamak

    CERN Document Server

    Ei-Sisi, A B

    2002-01-01

    In Egyptor Tokamak, the limiter is used for separation of the plasma from the vessel. In this work an overview of limiter types, and construction of limiter in Egyptor Tokamak is discussed. Also simulation results of the radial electron density distribution in case of limiter are presented. The results of the simulation are in agreement with the experimental and analytical results.

  13. Power limits for microbial life

    Directory of Open Access Journals (Sweden)

    Doug eLaRowe

    2015-07-01

    Full Text Available To better understand the origin, evolution and extent of life, we seek to determine the minimum flux of energy needed for organisms to remain viable. Despite the difficulties associated with direct measurement of the power limits for life, it is possible to use existing data and models to constrain the minimum flux of energy required to sustain microorganisms. Here, a we apply a bioenergetic model to a well characterized marine sedimentary environment in order to quantify the amount of power organisms use in an ultralow-energy setting. In particular, we show a direct link between power consumption in this environment and the amount of biomass (cells cm-3 found in it. The power supply resulting from the aerobic degradation of particular organic carbon (POC at IODP Site U1370 in the South Pacific Gyre is between ~ 10-12 and 10-16 W cm-3. The rates of POC degradation are calculated using a continuum model while Gibbs energies have been computed using geochemical data describing the sediment as a function of depth. Although laboratory-determined values of maintenance power do a poor job of representing the amount of biomass in U1370 sediments, the number of cells per cm-3 can be well-captured using a maintenance power, 190 zW cell-1, two orders of magnitude lower than the lowest value reported in the literature. In addition, we have combined cell counts and calculated power supplies to determine that, on average, the microorganisms at Site U1370 require 50 – 3500 zW cell-1, with most values under ~300 zW cell-1. Furthermore, we carried out an analysis of the absolute minimum power requirement for a single cell to remain viable to be on the order of 1 zW cell-1.

  14. Internal polarization limits coronagraph contrast

    Science.gov (United States)

    Breckinridge, James Bernard; Lam, Wai Sze T.; Chipman, Russell A.

    2015-08-01

    The performance of exoplanet imaging coronagraphs is limited by internal polarization. The point spread function (PSF) of these systems is determined by the details of the opto-mechanical layout selected to package the system and by the highly reflective metal thin films needed to maintain high optical system transmittance. To obtain the high contrast levels needed for terrestrial exoplanet science requires a comprehensive understanding of the vector electromagnetic wave from the source through the system. The literature contains many studies of polarization transmissivity of telescopes and instruments for the purpose of photo-polarimetry. Here we report for the first time the effects of polarization on high-performance image quality.We modeled a typical 2.4-meter Cassegrain telescope system with one 90-degree fold mirror and analyzed the system for polarization aberrations.We find: 1. The image plane irradiance distribution is the linear superposition of four PSF images: One for each of the two orthogonal polarizations and one for each of two cross-product polarization terms. 2. The PSF image is brighter by 9% for one polarization component compared to its orthogonal state. 3. The image of the PSF for orthogonal components are shifted across the focal plane with respect to each other, causing the PSF image for astronomical sources (polarized or unpolarized) to become slightly elongated (elliptical) with a centroid separation of about 0.6 masec. 4. The orthogonally polarized components of unpolarized sources contain different wavefront aberrations, which are separated by approximately 32 milliwaves. This implies that a wavefront correction system cannot optimally correct the aberrations for all polarizations simultaneously. 5. The polarization aberrations couple small parts (~1E-5) of each polarization component of the light into the orthogonal polarization to create highly distorted secondary, or “ghost” PSF image.. The radius of the spatial extent of the 90

  15. Status of the observed and predicted b anti-b production at the Tevatron

    Energy Technology Data Exchange (ETDEWEB)

    Happacher, F.; Giromini, P.; /Frascati; Ptohos, F.; /Cyprus U.

    2005-09-01

    The authors review the experimental status of the b-quark production at the Fermilab Tevatron. They compare all available measurements to perturbative QCD predictions (NLO and FONLL) and also to the parton-level cross section evaluated with parton-shower Monte Carlo generators. They examine both the single b cross section and the so called b{bar b} correlations. The review shows that the experimental situation is quite complicated because the measurements appear to be inconsistent among themselves. In this situation, there is no solid basis to either claim that perturbative QCD is challenged by these measurements or, in contrast, that long-standing discrepancies between data and theory have been resolved by incrementally improving the measurements and the theoretical prediction.

  16. THE CLINICAL AND IMMUNOLOGICAL EFFECTS OF ANTI-B-CELL THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS

    Directory of Open Access Journals (Sweden)

    Elena Nikolayevna Aleksandrova

    2012-01-01

    Full Text Available Objective: to study the time course of changes in acute-phase parameters and in the levels of autoantibodies, B lymphocytes, immunoglobulin (Ig classes G, M, and A in patients with rheumatoid arthritis (RA 2, 8, 16, and 24 weeks after initiation of therapy with rituximab (RTM.

  17. a Study of Neutral B Meson - Neutral Anti-B Meson Mixing Using the ARGUS Detector.

    Science.gov (United States)

    Tzamariudaki, Ekaterini

    1995-01-01

    Using the ARGUS detector at the e^+e ^- storage ring DORIS II at DESY, a study of the decay |{B}^0--> D^{*+}l^-|{v } has been performed by exploiting a partial D^{*+} reconstruction technique. The branching ratio was determined to be (4.4 +/- 0.3 +/- 0.3)% for this mode, and for the higher excited D_sp {(J)}{*} states Br( |{B}^0--> D_sp {(J)}{*}^+ l^ -|{v})=(2.5+/- 0.6+/-0.5)%. Furthermore, the inclusive D^{*+} branching ratio in B decays was measured by fully reconstructing D^{*+} candidates. Using a tagged subset of this sample of B ^0 meson decays in the mode =B ^0--> D^{*+}l ^-=v, B_sp{d}{0 }longleftrightarrow=B_sp{d }{0} oscillations have been studied. For this purpose two tagging techniques have been applied: the standard method of using fast leptons, and a new technique which makes use of kaons to tag the b flavour content. Combining the values obtained by these two methods, the B ^0=B^0 mixing parameter chi_{d}, used to denote the strength of the oscillations, was determined to be chi_{d} = 0.165+/-0.057. In addition, using fully reconstructed D ^{*+} candidates, a third study of the B^0=B^0 mixing parameter was carried out by investigating D^ {*+}K^{+/-} correlations. The mixing measurements obtained using kaons to tag the B meson flavour employ this technique for the first time. Future CP violation measurements at B Factories will place critical reliance on this method. Finally, using the extracted value for the mixing parameter chi_{d}, the CKM matrix element V_{td} was determined and the B_sp{s }{0}=B_sp{s}{0 } mixing parameter chi_ {s} was obtained.

  18. A new direction in the treatment of rheumatoid arthritis: anti-B cell therapy

    Directory of Open Access Journals (Sweden)

    G V Lukina

    2009-01-01

    Full Text Available Ревматоидный артрит (РА – аутоиммунное ревматическое заболевание неизвестной этиологии, характеризующееся хроническим эрозивным артритом (синовитом и нередким системным воспа- лительным поражением внутренних органов. Его распространенность в популяции колеблется от 0.5% до 1.0% [1]. Социальное и медицинское значение РА определяется значительной инвалидностью и сокращением продолжительности жизни пациентов [2-4]. До недавнего времени патогенетические механизмы развития РА рассматривались главным образом с точки зрения дефектов Т-клеточной иммунорегуляции [5-7]. Однако данные экспериментальных исследований, свидетельствующие о фундаментальной роли В-лимфоцитов в нарушении иммунного ответа при РА [7-11], послужили стимулом для изучения этих клеток в качестве объекта антиревматической терапии. В результате в арсенал ревматологов вошел анти-В-клеточный биологический препарат ритуксимаб, или Мабтерa [12-16]. Ритуксимаб (мабтера представляет собой генноинженерное химерное моноклональное антитело, состоящее из человеческого и мышиного белка. Оно направлено против антигена CD20, находящегося на поверхности пре В-клеток и зрелых В-клеток, но не на развивающихся из них плазматических клетках, которые являются продуцентами антител. Поэтому применение ритуксимаба приводит к резкому сокращению на длительный срок популяции зрелых В-клеток; количество же вырабатывающих антитела плазматических клеток существенно не изменяется. Соответственно этому уровень циркулирующих антител не обнаруживает значительного снижения. CD20 отсутствует также на стволовых, дендритных и прo-В клетках, в связи с чем ритуксимаб не влияет на их функцию и количество. Период полувыведения препарата из сыворотки составляет около 20 дней [17].

  19. ANTI-B-CELL THERAPY AT IMMUNE INFLAMMATORY RHEUMATIC DISEASES: EFFICACY AND TOLERABILITY IN 229 PATIENTS

    Directory of Open Access Journals (Sweden)

    L. P. Ananieva

    2014-01-01

    Full Text Available Objective: to assess the efficacy and tolerability of Rituximab treatment in patients with serious immune inflammatory rheumatic diseases (IRD like systemic lupus erythematosus (SLE, systemic sclerosis (SS, systemic vasculitis (SV, Sjogren syndrome (SjS, dermatomyositis/polymyositis (DM/PM.Subjects and methods. The clinical efficacy has been analyzed in 229 patients with IRD: SLE (n=97, SV (n=50, SS (n=40, SjS (n=23 and DM/PM (n=19. Rituximab treatment was accompanied by administration of glucocorticoids and/or immunosuppressive drugs. Most patients demonstrated resistance to or low tolerability of standard therapy. Efficacy of treatment was analyzed in each group with the criteria relevant for each disease. To compare clinical response to the treatment between the groups we used gradations accepted by international registries: complete (good response, partial response, no response. Average duration of monitoring comprised 72 (1–288 weeks after the first introduction of Rituximab. Average Rituximab dose administered to patients over the period of monitoring was low and varied from 1.6±0.84 in DM/PM to 3.1±1.75 in SV. About 80% of patients received one or two courses of Rituximab except for patients with SS (half of them received three and more courses.Results. «Complete response» was observed in 50.6%, «partial response» – in 35% of patients. Rituximab courses provided positive dynamics in clinical scores and allowed to reduce supportive dose of glucocorticoids and to lower the dose or withdraw of immune-stimulating drugs. Multiple Rituximab courses provided stable and longlasting effect. Recurrences were observed less frequently, whereas efficacy of the therapy increased during a year and longer. Occurrence of adverse events and mortality rate were comparable to data of other national Rituximab registries.Conclusion. The results of the study may prove administration of Rituximab in patients with resistance to standard therapy

  20. Observation of B0(s) - anti-B0(s) Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Abulencia, A.; Adelman, Jahred A.; Affolder, T.; Akimoto, T.; Albrow, M.G.; Ambrose, D.; Amerio, S.; Amidei, D.; Anastassov, A.; Anikeev, K.; Annovi, A.; /Taiwan, Inst.

    2006-09-01

    The authors report the observation of B{sub s}{sup 0}-{bar B}{sub s}{sup 0} oscillations from a time-dependent measurement of the B{sub s}{sup 0}-{bar B}{sub s}{sup 0} oscillation frequency {Delta}m{sub s}. Using a data sample of 1 fb{sup -1} of p{bar p} collisions at {radical}s = 1.96 TeV collected with the CDF II detector at the Fermilab Tevatron, they find signals of 5600 fully reconstructed hadronic B{sub s} decays, 3100 partially reconstructed hadronic B{sub s} decays, and 61,500 partially reconstructed semileptonic B{sub s} decays. They measure the probability as a function of proper decay time that the B{sub s} decays with the same, or opposite, flavor as the flavor at production, and they find a signal for B{sub s}{sup 0}-{bar B}{sub s}{sup 0} oscillations. The probability that random fluctuations could produce a comparable signal is 8 x 10{sup -8}, which exceeds 5{sigma} significance. They measure {Delta}m{sub s} = 17.77 {+-} 0.10(stat) {+-} 0.07(syst) ps{sup -1} and extract |V{sub td}/V{sub ts}| = 0.2050 {+-} 0.0007(exp{sub -0.0060}{sup +0.0081})(theor).

  1. Measurement of B0-anti-B0 Flavor Oscillations in Hadronic B0 Decays

    OpenAIRE

    2001-01-01

    Flavor oscillations of neutral $B$ mesons have been studied in $e^+e^-$ annihilation data collected with the BABAR detector at center-of-mass energies near the $\\Upsilon(4S)$ resonance. The data sample used for this purpose consists of events in which one $B^0$ meson is reconstructed in a hadronic decay mode, while the flavor of the recoiling $B^0$ is determined with a tagging algorithm that exploits the correlation between the flavor of the heavy quark and the charges of its decay products. ...

  2. Search for B0(S) Anti-B0(S) Oscillations at SLD

    CERN Document Server

    Moore, T

    2003-01-01

    We present preliminary results on the time dependence of B sub s sup 0 - (bar B) sub s sup 0 and B sub d sup 0 - (bar B) sub d sup 0 mixing using a sample of 400,000 hadronic Z sup 0 decays collected by the SLD experiment at the SLC. The analyses take advantage of the excellent decay length resolution of the CCD vertex detector. The B or (bar B) production flavor is determined by exploiting the large forward-backward asymmetry of polarized Z sup 0 -> b(bar b) decays. This flavor tag is enhanced by incorporating additional information from the hemisphere opposite that of the reconstructed B decay. The B sub d sup 0 - (bar B) sub d sup 0 mixing analysis uses the charge of high momentum kaons to identify the B or (bar B) decay flavor. The result is DELTA m sub d = 0.503 +- 0.028(stat) +- 0.020(syst) ps sup - sup 1. The results of three separate B sub s sup 0 - (bar B) sub s sup 0 mixing analyses are presented. These analyses determine the B decay flavor using the lepton charge in B semileptonic decays, the charg...

  3. Measurement of B0-anti-B0 Flavor Oscillations in Hadronic B0 Decays

    CERN Document Server

    Aubert, Bernard

    2002-01-01

    Flavor oscillations of neutral $B$ mesons have been studied in $e^+e^-$ annihilation data collected with the BABAR detector at center-of-mass energies near the $\\Upsilon(4S)$ resonance. The data sample used for this purpose consists of events in which one $B^0$ meson is reconstructed in a hadronic decay mode, while the flavor of the recoiling $B^0$ is determined with a tagging algorithm that exploits the correlation between the flavor of the heavy quark and the charges of its decay products. From the time development of the observed mixed and unmixed final states we determine the $B^0$-$\\bar B^0$ oscillation frequency $\\Delta m_d$ to be $0.516 \\pm 0.016 ({stat}) \\pm 0.010 ({syst}) {\\rm ps}^{-1}$.

  4. Anti B cell targeted therapy for autoimmune hemolytic anemia in an infant

    Directory of Open Access Journals (Sweden)

    Darshak Makadia

    2013-01-01

    Full Text Available Autoimmune hemolytic anemia (AIHA is an immune mediated destruction of erythrocytes, which has a good prognosis in children. It is known to have chronic, remitting or relapsing course, especially in infants and adolescents. Treatment of refractory or relapsing AIHA is a challenge as the other aim of the treatment is to avoid prolonged exposure to steroids or other immunosuppressants in small children. Rituximab is used in patients who are non-responsive to conventional treatment such as steroids, intravenous immunoglobulins and transfusion therapy. It has varying therapeutic success rate. We report a case of AIHA in a 4-month-old infant who had ill-sustained response to conventional therapy, but responded to rituximab.

  5. On thermodynamic limits of entropy densities

    NARCIS (Netherlands)

    Moriya, H; Van Enter, A

    1998-01-01

    We give some sufficient conditions which guarantee that the entropy density in the thermodynamic limit is equal to the thermodynamic limit of the entropy densities of finite-volume (local) Gibbs states.

  6. Infrared limit in external field scattering

    CERN Document Server

    Herdegen, Andrzej

    2012-01-01

    Scattering of electrons/positrons by external classical electromagnetic wave packet is considered in infrared limit. In this limit the scattering operator exists and produces physical effects, although the scattering cross-section is trivial.

  7. FDA Suggests Limits on Lead in Cosmetics

    Science.gov (United States)

    ... page: https://medlineplus.gov/news/fullstory_162726.html FDA Suggests Limits on Lead in Cosmetics Agency notes ... the authority to enforce such a limit, the FDA recommended in a draft guidance issued Thursday that ...

  8. High temperature superconducting fault current limiter

    Energy Technology Data Exchange (ETDEWEB)

    Hull, John R. (Hinsdale, IL)

    1997-01-01

    A fault current limiter (10) for an electrical circuit (14). The fault current limiter (10) includes a high temperature superconductor (12) in the electrical circuit (14). The high temperature superconductor (12) is cooled below its critical temperature to maintain the superconducting electrical properties during operation as the fault current limiter (10).

  9. The density limit in JET diverted plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, D.J.; Clement, S.; Gottardi, N.; Gowers, C.; Harbour, P.; Loarte, A.; Horton, L.; Lingertat, J.; Lowry, C.G.; Saibene, G.; Stamp, M.; Stork, D. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Monk, R. [Royal Holloway Coll., London (United Kingdom). Dept. of Physics

    1994-07-01

    In JET limiter plasmas the density limit is associated with radiated power fractions of 100% and, in plasmas with carbon limiters, it is invariably disruptive. However, in discharges with solid beryllium limiters the limit is identified with the formation of a MARFE and disruptions are less frequent. In addition, the improved conditioning of the vessel arising from the use of beryllium has significantly improved the density limit scaling, so that the maximum density rises with the square root of the input power. In diverted plasmas several confinement regimes exist, making the characterization of the density limit more complex. While the density limit in L-mode plasmas is generally disruptive, the limit in ELMy and ELM-free H-modes generally prompts a return to the L-mode and a disruption is not inevitable. The density limit does rise with the increasing power, but the L-to-H transition complicates the analysis. Nevertheless, at low plasma currents (<2 MA), densities significantly above the Greenwald limit can be achieved, while at higher currents power handling limitations have constrained the range of density which can be achieved. (authors). 7 refs., 4 figs.

  10. 50 CFR 38.13 - Speed limits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Speed limits. 38.13 Section 38.13 Wildlife... NATIONAL WILDLIFE REFUGE SYSTEM MIDWAY ATOLL NATIONAL WILDLIFE REFUGE Prohibitions § 38.13 Speed limits. No person on Midway Atoll National Wildlife Refuge will exceed the speed limit for automobiles,...

  11. 50 CFR 20.33 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Possession limit. 20.33 Section 20.33... PLANTS (CONTINUED) MIGRATORY BIRD HUNTING Possession § 20.33 Possession limit. No person shall possess more migratory game birds taken in the United States than the possession limit or the...

  12. 47 CFR 18.307 - Conduction limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conduction limits. 18.307 Section 18.307... Standards § 18.307 Conduction limits. For the following equipment, when designed to be connected to the... on any frequency or frequencies shall not exceed the limits in the following tables. Compliance...

  13. 40 CFR 63.802 - Emission limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Emission limits. 63.802 Section 63.802... Standards for Wood Furniture Manufacturing Operations § 63.802 Emission limits. (a) Each owner or operator of an existing affected source subject to this subpart shall: (1) Limit VHAP emissions from...

  14. 38 CFR 21.1033 - Time limits.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Time limits. 21.1033... Time limits. The provisions of this section are applicable to informal claims and formal claims. (a) Failure to furnish form, information, or notice of time limit. VA's failure to give a claimant...

  15. 38 CFR 3.109 - Time limit.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Time limit. 3.109 Section..., Compensation, and Dependency and Indemnity Compensation Administrative § 3.109 Time limit. (a) Notice of time limit for filing evidence. (1) If a claimant's application is incomplete, the claimant will be...

  16. 34 CFR 685.203 - Loan limits.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Loan limits. 685.203 Section 685.203 Education..., DEPARTMENT OF EDUCATION WILLIAM D. FORD FEDERAL DIRECT LOAN PROGRAM Borrower Provisions § 685.203 Loan limits... Direct Stafford/Ford Loan Program and Federal Stafford Loan Program aggregate limits. The...

  17. 40 CFR 1501.8 - Time limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Time limits. 1501.8 Section 1501.8 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY NEPA AND AGENCY PLANNING § 1501.8 Time limits. Although the Council has decided that prescribed universal time limits for the entire NEPA process are...

  18. 14 CFR 36.103 - Noise limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Noise limits. 36.103 Section 36.103... Noise limits. (a) For subsonic transport category large airplanes and subsonic jet airplanes compliance... greater than the Stage 3 noise limit prescribed in section B36.5(c) of appendix B of this part. (c)...

  19. 50 CFR 648.145 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession limit. 648.145 Section 648.145... Fishery § 648.145 Possession limit. (a) No person shall possess more than 25 black sea bass, in, or... that is not eligible for a black sea bass moratorium permit are subject to this possession limit....

  20. 7 CFR 1400.106 - Payment limits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Payment limits. 1400.106 Section 1400.106 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS Payment Limitation § 1400.106 Payment limits. (a) Payments made...

  1. 50 CFR 635.20 - Size limits.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Size limits. 635.20 Section 635.20..., DEPARTMENT OF COMMERCE ATLANTIC HIGHLY MIGRATORY SPECIES Management Measures § 635.20 Size limits. Link to an... (160 cm), LJFL. (4) The Atlantic blue and white marlin minimum size limits, specified in paragraphs...

  2. 7 CFR 3560.63 - Loan limits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan limits. 3560.63 Section 3560.63 Agriculture... DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS Direct Loan and Grant Origination § 3560.63 Loan limits. (a... housing tax credits, limits will be those specified in § 3560.53(l). (2) Developer's fee. While,...

  3. 14 CFR 36.501 - Noise limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Noise limits. 36.501 Section 36.501..., Commuter Category Airplanes § 36.501 Noise limits. (a) Compliance with this subpart must be shown for— (1... applicable limit set in Part D of appendix F. (c) For aircraft covered by this subpart for...

  4. 17 CFR 150.2 - Position limits.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Position limits. 150.2 Section 150.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION LIMITS ON POSITIONS § 150.2 Position limits. No person may hold or control positions, separately or in combination, net...

  5. 7 CFR 4274.331 - Loan limits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan limits. 4274.331 Section 4274.331 Agriculture... (IRP) § 4274.331 Loan limits. (a) Intermediary. (1) No loan to an intermediary will exceed the maximum... be used for loans to ultimate recipients that exceed $150,000. This limit does not apply to...

  6. 47 CFR 15.207 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conducted limits. 15.207 Section 15.207... Conducted limits. (a) Except as shown in paragraphs (b) and (c) of this section, for an intentional radiator... to 30 MHz, shall not exceed the limits in the following table, as measured using a 50 μH/50 ohms...

  7. 18 CFR 807.2 - Time limits.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Time limits. 807.2... WITHDRAWAL REGISTRATION § 807.2 Time limits. (a) Except for agricultural water use projects, all registration... limit the responsibility of a project sponsor to apply for and obtain an approval as may be...

  8. 47 CFR 15.315 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conducted limits. 15.315 Section 15.315... Communications Service Devices § 15.315 Conducted limits. An unlicensed PCS device that is designed to be connected to the public utility (AC) power line must meet the limits specified in § 15.207....

  9. 14 CFR 36.805 - Noise limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Noise limits. 36.805 Section 36.805...: AIRCRAFT TYPE AND AIRWORTHINESS CERTIFICATION Helicopters § 36.805 Noise limits. (a) Compliance with the... levels of the helicopter are no greater than the applicable limits prescribed under section H36.305...

  10. 32 CFR 935.132 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Speed limits. 935.132 Section 935.132 National... WAKE ISLAND CODE Motor Vehicle Code § 935.132 Speed limits. Each person operating a motor vehicle on..., or both; and (b) That does not exceed 40 miles an hour or such lesser speed limit as may be posted....

  11. 32 CFR 806.22 - Time limits.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Time limits. 806.22 Section 806.22 National... INFORMATION ACT PROGRAM § 806.22 Time limits. Any FOIA appeals received after the 60-day time limit are not processed, unless the requester provides adequate justification for failing to comply with the time...

  12. 47 CFR 90.1215 - Power limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Power limits. 90.1215 Section 90.1215... § 90.1215 Power limits. The transmitting power of stations operating in the 4940-4990 MHz band must not exceed the maximum limits in this section. (a)(1) The maximum conducted output power should not...

  13. 5 CFR 847.304 - Time limit.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Time limit. 847.304 Section 847.304... Procedures for Elections Under the Retroactive Provisions § 847.304 Time limit. (a) Except as provided in paragraph (b) of this section, the time limit for making an election under subpart D of this part is...

  14. 50 CFR 648.125 - Possession limit.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession limit. 648.125 Section 648.125... § 648.125 Possession limit. (a) No person shall possess more than 10 scup in, or harvested from, the EEZ... moratorium permit are subject to this possession limit. The owner, operator, and crew of a charter or...

  15. 10 CFR 1017.21 - Limited access.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Limited access. 1017.21 Section 1017.21 Energy DEPARTMENT... INFORMATION Access to Unclassified Controlled Nuclear Information § 1017.21 Limited access. (a) A person who is not eligible for routine access to specific UCNI under § 1017.20 may request limited access...

  16. SEMICLASSICAL LIMIT OF NONLINEAR SCHRODINGER EQUATION (Ⅱ)

    Institute of Scientific and Technical Information of China (English)

    张平

    2002-01-01

    In this paper, we use the Wigner measure approach to study the semiclassical limit of nonlinear Schrodinger equation in small time. We prove that: the limits of the quantum density: pε =: |ψε|2, and the quantum momentum: Jε =: εIm(ψεψε) satisfy the compressible Euler equations before the formation of singularities in the limit system.

  17. 12 CFR 616.6600 - Leasing limit.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Leasing limit. 616.6600 Section 616.6600 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LEASING § 616.6600 Leasing limit. All leases made by Farm Credit System institutions shall be subject to the lending and leasing limit in subpart...

  18. 47 CFR 73.1725 - Limited time.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Limited time. 73.1725 Section 73.1725... Rules Applicable to All Broadcast Stations § 73.1725 Limited time. (a) Operation is applicable only to... stations on the channel. (b) No authorization will be granted for: (1) A new limited time station; (2)...

  19. Multiple Limit Cycles in an Immune System

    Institute of Scientific and Technical Information of China (English)

    Xun-cheng Huang; Le-min Zhu; Minaya Villasana

    2008-01-01

    The nonlinear oscillatory phenomenon has been observed in the system of immune response, which corresponds to the limit cycles in the mathematical models. We prove that the system simulating an immune response studied by Huang has at least three limit cycles in the system. The conditions for the multiple limit cycles are useful in analyzing the nonlinear oscillation in immune response.

  20. Optimizing discrete control systems with phase limitations

    Energy Technology Data Exchange (ETDEWEB)

    Shakhverdian, S.B.; Abramian, A.K.

    1981-01-01

    A new method is proposed for solving discrete problems of optimizing control systems with limitations on the phase coordinates. Results are given from experimental research which demonstrate the need to introduce tangential limitations independent of the method of accounting for the phase limitations.

  1. 40 CFR 264.94 - Concentration limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Concentration limits. 264.94 Section... From Solid Waste Management Units § 264.94 Concentration limits. (a) The Regional Administrator will specify in the facility permit concentration limits in the ground water for hazardous constituents...

  2. 12 CFR 24.4 - Investment limits.

    Science.gov (United States)

    2010-01-01

    ... ENTITIES, COMMUNITY DEVELOPMENT PROJECTS, AND OTHER PUBLIC WELFARE INVESTMENTS § 24.4 Investment limits. (a) Limits on aggregate outstanding investments. A national bank's aggregate outstanding investments under... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Investment limits. 24.4 Section 24.4 Banks and...

  3. Determination of the meteor limiting magnitude

    Science.gov (United States)

    Kingery, A.; Blaauw, R. C.

    2017-09-01

    We present our method to calculate the meteor limiting magnitude. The limiting meteor magnitude defines the faintest magnitude at which all meteors are still detected by a given system. An accurate measurement of the limiting magnitude is important in order to calculate the meteoroid flux from a meteor shower or sporadic source. Since meteor brightness is linked to meteor mass, the limiting magnitude is needed to calculate the limiting mass of the meteor flux measurement. The mass distribution of meteoroids is thought to follow a power law, thus being slightly off in the limiting magnitude can have a significant effect on the measured flux. Sky conditions can change on fairly short timescales; therefore one must monitor the meteor limiting magnitude at regular intervals throughout the night, rather than just measuring it once. We use the stellar limiting magnitude as a proxy of the meteor limiting magnitude. Our method for determining the stellar limiting magnitude and how we transform it into the meteor limiting magnitude is presented. These methods are currently applied to NASA's wide-field meteor camera network to determine nightly fluxes, but are applicable to other camera networks.

  4. The Translation of Numerals and its Limits

    Institute of Scientific and Technical Information of China (English)

    吴贤雯

    2013-01-01

    Through probing into the diversity of numerals’functions in language use which gives prominence to the importance of numeral translation, this paper aims to analyze the limits of numeral translation and explain the cause for these limits. The analy-sis of the limits in numeral translation is guided by the principle of functional equivalence. It is discussed that in numeral transla-tion, the limits on different levels of culture, image, sound and form arise when the full functional equivalence can not be achieved. Furthermore, this paper finds that the differences in culture and formal structure as well as the semantic fuzziness are three reasons for the presence of limits in numeral translation. However, the author suggests that these limits in numeral transla-tion can be adjusted with the further development of research on translation methodology and the deep infiltration of different cultures.

  5. Existence of Multiagent Equilibria with Limited Agents

    CERN Document Server

    Bowling, M; 10.1613/jair.1332

    2011-01-01

    Multiagent learning is a necessary yet challenging problem as multiagent systems become more prevalent and environments become more dynamic. Much of the groundbreaking work in this area draws on notable results from game theory, in particular, the concept of Nash equilibria. Learners that directly learn an equilibrium obviously rely on their existence. Learners that instead seek to play optimally with respect to the other players also depend upon equilibria since equilibria are fixed points for learning. From another perspective, agents with limitations are real and common. These may be undesired physical limitations as well as self-imposed rational limitations, such as abstraction and approximation techniques, used to make learning tractable. This article explores the interactions of these two important concepts: equilibria and limitations in learning. We introduce the question of whether equilibria continue to exist when agents have limitations. We look at the general effects limitations can have on agent b...

  6. The Limitations and Application Methods of Suggestopedia

    Institute of Scientific and Technical Information of China (English)

    李苗苗; 宋宝梅

    2015-01-01

    For a long time,college English teaching was mainly teacher-centered.Teachers played a dominant role in the classroom whereas students played a passive role.The"Suggestopedia"theory is such an effective way.However,there exist some limitations when apply the Suggestopedia theory.Teachers must pay attention to these limitations when apply the Suggestopedia theory.This thesis not only presents the limitations but also give some advises to the proper application of Suggestopedia Theory in teaching.

  7. 19 CFR 145.23 - Time limits.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Time limits. 145.23 Section 145.23 Customs Duties... (CONTINUED) MAIL IMPORTATIONS Administrative Review of Mail Entries § 145.23 Time limits. A mail entry may be... requests such amendment within the time limits prescribed therein (see §§ 173.4 and 173.5 of this...

  8. Investigation of pulsed voltage limiters characteristics

    Directory of Open Access Journals (Sweden)

    Karimov A. V.

    2012-06-01

    Full Text Available A new method for measuring the voltage limit is offered. It has been designed to measure high-power pulsed current of voltage limiters. The error of this method is half as much as the error of the known method of direct measurement. The investigation of dependence of power capability of single-crystal and double-crystal voltage limiters and of the pulsed operation time on pulse duration.

  9. The Limitations and Application Methods of Suggestopedia

    Institute of Scientific and Technical Information of China (English)

    李苗苗; 宋宝梅

    2015-01-01

    For a long time,college English teaching was mainly teacher-centered.Teachers played a dominant role in the classroom whereas students played a passive role.The"Suggestopedia" theory is such an effective way.However,there exist some limitations when apply the Suggestopedia theory.Teachers must pay attention to these limitations when apply the Suggestopedia theory.This thesis not only presents the limitations but also give some advises to the proper application of Suggestopedia Theory in teaching.

  10. Inproved grade length limitation of freeways

    Institute of Scientific and Technical Information of China (English)

    XING En-hui; PEI Yu-long

    2006-01-01

    A method of ascertaining grade length limitation of freeways in mountain terrain is presented. The relationship models between 15th percentile speeds and grades were built through the surveys and analyses of operation speeds on 7 typical sections of 3 freeways in mountain terrain. Using 15th percentile and 85th percentile as speed limitations, the methods of determining admitted velocities were put forward according to the grades. Deceleration distances of longitudinal slopeways were analyzed utilizing the theories of vehicle. According to the results of analysis, grade length limitation was loosed. Finally the values of grade length limitation for freeways were put forward. The results could be used as references for freeway design.

  11. Fundamental gravitational limitations to quantum computing

    CERN Document Server

    Gambini, R; Pullin, J; Gambini, Rodolfo; Porto, Rafael A.; Pullin, Jorge

    2005-01-01

    Lloyd has considered the ultimate limitations physics places on quantum computers. He concludes in particular that for an ``ultimate laptop'' (a computer of one liter of volume and one kilogram of mass) the maximum number of operations per second is bounded by $10^{51}$. The limit is derived considering ordinary quantum mechanics. Here we consider additional limits that are placed by quantum gravity ideas, namely the use of a relational notion of time and fundamental gravitational limits that exist on time measurements. We then particularize for the case of an ultimate laptop and show that the maximum number of operations is further constrained to $10^{47}$ per second.

  12. 47 CFR 80.511 - Assignment limitations.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Assignment limitations. 80.511 Section 80.511 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Private Coast Stations and Marine Utility Stations § 80.511 Assignment limitations. (a...

  13. Central Limit Theorem for Coloured Hard Dimers

    Directory of Open Access Journals (Sweden)

    Maria Simonetta Bernabei

    2010-01-01

    Full Text Available We study the central limit theorem for a class of coloured graphs. This means that we investigate the limit behavior of certain random variables whose values are combinatorial parameters associated to these graphs. The techniques used at arriving this result comprise combinatorics, generating functions, and conditional expectations.

  14. Optical limiting in semiconductor-doped glasses

    Science.gov (United States)

    Bindra, K. S.; Oak, S. M.; Rustagi, K. C.

    1996-02-01

    We report optical limiting at 527 nm in two Schott semiconductor-doped glasses OG530 and OG515. These two glasses show quite contrasting nonlinear optical behaviour. The glass OG515 shows strong clamping while OG530 shows no clamping in optical limiting inspite of having much larger nonlinear refractive index. Similarly OG530 exhibits saturation of absorption while OG515 does not.

  15. Limited dependent variable models for panel data

    NARCIS (Netherlands)

    Charlier, E.

    1997-01-01

    Many economic phenomena require limited variable models for an appropriate treatment. In addition, panel data models allow the inclusion of unobserved individual-specific effects. These models are combined in this thesis. Distributional assumptions in the limited dependent variable models are

  16. 14 CFR 43.16 - Airworthiness limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Airworthiness limitations. 43.16 Section 43.16 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT MAINTENANCE, PREVENTIVE MAINTENANCE, REBUILDING, AND ALTERATION § 43.16 Airworthiness limitations. Each...

  17. 33 CFR 401.28 - Speed limits.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Speed limits. 401.28 Section 401... TRANSPORTATION SEAWAY REGULATIONS AND RULES Regulations Seaway Navigation § 401.28 Speed limits. (a) The maximum speed over the bottom for a vessel of more than 12 m in overall length shall be regulated so as not...

  18. 47 CFR 78.115 - Modulation limits.

    Science.gov (United States)

    2010-10-01

    ... SERVICE Technical Regulations § 78.115 Modulation limits. (a) If amplitude modulation is employed..., frequencies 78.36 Cross reference to other rules 78.3 D Definitions 78.5 E Eligibility for license 78.13 Emission designator 78.104 Emissions; emission limitations 78.103 Equal employment opportunities...

  19. 40 CFR 1502.7 - Page limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Page limits. 1502.7 Section 1502.7 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.7 Page limits. The text of final environmental impact statements (e.g., paragraphs (d) through (g) of §...

  20. 40 CFR 503.43 - Pollutant limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pollutant limits. 503.43 Section 503... THE USE OR DISPOSAL OF SEWAGE SLUDGE Incineration § 503.43 Pollutant limits. (a) Firing of sewage... 40 CFR part 61. (c) Pollutant limit—lead. (1) The average daily concentration for lead in...

  1. 46 CFR 298.21 - Limits.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Limits. 298.21 Section 298.21 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION VESSEL FINANCING ASSISTANCE OBLIGATION GUARANTEES Guarantees § 298.21 Limits. (a) Actual Cost basis. We will issue a guarantee on an amount of the...

  2. 47 CFR 73.855 - Ownership limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Ownership limits. 73.855 Section 73.855 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Low Power FM Broadcast Stations (LPFM) § 73.855 Ownership limits. (a) No authorization for an...

  3. 5 CFR 1205.23 - Time limits.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Time limits. 1205.23 Section 1205.23 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRIVACY ACT REGULATIONS Amendment of Records § 1205.23 Time limits. The Clerk of the Board, Regional Director, or...

  4. 10 CFR 52.9 - Jurisdictional limits.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Jurisdictional limits. 52.9 Section 52.9 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) LICENSES, CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52.9 Jurisdictional limits. No permit, license, standard design approval, or standard...

  5. 19 CFR 357.106 - Time limits.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Time limits. 357.106 Section 357.106 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE SHORT SUPPLY PROCEDURES § 357.106 Time limits. (a) The Secretary will determine, no later than the day specified in paragraph (b) of...

  6. 24 CFR 585.202 - Award limits.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Award limits. 585.202 Section 585.202 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued... DEVELOPMENT COMMUNITY FACILITIES YOUTHBUILD PROGRAM Youthbuild Planning Grants § 585.202 Award limits....

  7. 32 CFR 169a.19 - Study limits.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Study limits. 169a.19 Section 169a.19 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING COMMERCIAL ACTIVITIES PROGRAM PROCEDURES Procedures § 169a.19 Study limits. No DoD funds shall be available to perform any...

  8. 38 CFR 36.4214 - Geographical limits.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Geographical limits. 36.4214 Section 36.4214 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... Preparation General Provisions § 36.4214 Geographical limits. The site for any manufactured home...

  9. 27 CFR 11.4 - Jurisdictional limits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 11.4 Section 11.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS CONSIGNMENT SALES Scope of Regulations § 11.4 Jurisdictional limits....

  10. 14 CFR 25.25 - Weight limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Weight limits. 25.25 Section 25.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Flight General § 25.25 Weight limits. (a) Maximum weights....

  11. 49 CFR 236.753 - Limits, interlocking.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Limits, interlocking. 236.753 Section 236.753 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Limits, interlocking. The tracks between the opposing home signals of an interlocking....

  12. 27 CFR 10.4 - Jurisdictional limits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 10.4 Section 10.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS COMMERCIAL BRIBERY Scope of Regulations § 10.4 Jurisdictional limits....

  13. 14 CFR 27.25 - Weight limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Weight limits. 27.25 Section 27.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Flight General § 27.25 Weight limits. (a) Maximum weight. The...

  14. 7 CFR 3560.612 - Loan limits.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Loan limits. 3560.612 Section 3560.612 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, DEPARTMENT OF AGRICULTURE DIRECT MULTI-FAMILY HOUSING LOANS AND GRANTS On-Farm Labor Housing § 3560.612 Loan limits. The...

  15. 27 CFR 8.4 - Jurisdictional limits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 8.4 Section 8.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS EXCLUSIVE OUTLETS Scope of Regulations § 8.4 Jurisdictional limits. (a)...

  16. 38 CFR 36.4411 - Geographical limits.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Geographical limits. 36.4411 Section 36.4411 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... Geographical limits. Any real property purchased, constructed, altered, improved, repaired, or...

  17. 49 CFR 10.43 - Time limits.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Time limits. 10.43 Section 10.43 Transportation Office of the Secretary of Transportation MAINTENANCE OF AND ACCESS TO RECORDS PERTAINING TO INDIVIDUALS Correction of Records § 10.43 Time limits. Within ten days (excluding Saturday, Sunday, and legal...

  18. 40 CFR 66.93 - Time limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Time limits. 66.93 Section 66.93 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) ASSESSMENT AND... limits. The Presiding Officer upon designation shall notify the parties and shall, if...

  19. 10 CFR 14.27 - Time limit.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Time limit. 14.27 Section 14.27 Energy NUCLEAR REGULATORY COMMISSION ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT Filing Procedures and Requirements § 14.27 Time limit. The claimant shall furnish evidence and information of the types described in 10 CFR...

  20. 40 CFR 61.162 - Emission limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 8 2010-07-01 2010-07-01 false Emission limits. 61.162 Section 61.162 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) NATIONAL... From Glass Manufacturing Plants § 61.162 Emission limits. (a) The owner or operator of an...

  1. 38 CFR 36.4523 - Geographical limits.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Geographical limits. 36.4523 Section 36.4523 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) LOAN GUARANTY Direct Loans § 36.4523 Geographical limits. Any real property purchased, constructed,...

  2. 40 CFR 503.13 - Pollutant limits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Pollutant limits. 503.13 Section 503.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SEWAGE SLUDGE STANDARDS FOR THE USE OR DISPOSAL OF SEWAGE SLUDGE Land Application § 503.13 Pollutant limits. (a) Sewage sludge....

  3. 14 CFR 29.25 - Weight limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Weight limits. 29.25 Section 29.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Flight General § 29.25 Weight limits. (a) Maximum weight....

  4. 47 CFR 90.1323 - Emission limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission limits. 90.1323 Section 90.1323 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1323 Emission limits....

  5. 25 CFR 87.3 - Time limits.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Time limits. 87.3 Section 87.3 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT USE OR DISTRIBUTION OF INDIAN JUDGMENT FUNDS § 87.3 Time limits. (a) The Secretary shall cause to begin as early as possible the necessary research...

  6. 47 CFR 24.133 - Emission limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Emission limits. 24.133 Section 24.133 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS SERVICES Narrowband PCS § 24.133 Emission limits. (a) The power of any emission shall be attenuated...

  7. 12 CFR 1805.402 - Assistance limits.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Assistance limits. 1805.402 Section 1805.402 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM Investment Instruments § 1805.402 Assistance limits....

  8. 47 CFR 15.107 - Conducted limits.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Conducted limits. 15.107 Section 15.107... Conducted limits. (a) Except for Class A digital devices, for equipment that is designed to be connected to... power line on any frequency or frequencies within the band 150 kHz to 30 MHz shall not exceed the...

  9. 47 CFR 10.430 - Character limit.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Character limit. 10.430 Section 10.430 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM Alert Message Requirements § 10.430 Character limit. A CMAS Alert Message processed by a Participating CMS Provider must...

  10. 14 CFR 31.14 - Weight limits.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Weight limits. 31.14 Section 31.14 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Flight Requirements § 31.14 Weight limits. (a) The range of weights...

  11. 27 CFR 6.4 - Jurisdictional limits.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Jurisdictional limits. 6.4 Section 6.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Scope of Regulations § 6.4 Jurisdictional limits. (a) General....

  12. 38 CFR 36.4332 - Geographical limits.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Geographical limits. 36.4332 Section 36.4332 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED... Geographical limits. Any real property purchased, constructed, altered, improved, or repaired with the...

  13. 12 CFR 308.546 - Limitations.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Limitations. 308.546 Section 308.546 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.546 Limitations. (a) The notice of hearing with...

  14. Common Cause Abduction : Its Scope and Limits

    NARCIS (Netherlands)

    Dziurosz-Serafinowicz, Patryk

    2012-01-01

    Patryk Dziurosz-Serafmowicz, Common Cause Abduction: Its Scope and Limits This article aims to analyze the scope and limits of common cause abduction which is a version of explanatory abduction based on Hans Reichenbach's Principle of the Common Cause. First, it is argued that common cause abduction

  15. 42 CFR 403.508 - Limitations.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Limitations. 403.508 Section 403.508 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Beneficiary Counseling and Assistance Grants § 403.508 Limitations. (a)...

  16. 30 CFR 18.47 - Voltage limitation.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Voltage limitation. 18.47 Section 18.47 Mineral... § 18.47 Voltage limitation. (a) A tool or switch held in the operator's hand or supported against his... particular voltage(s) are provided in the design and construction of the equipment, its wiring,...

  17. 14 CFR 142.31 - Advertising limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Advertising limitations. 142.31 Section 142...) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS General § 142.31 Advertising limitations. (a) A certificate holder may not conduct, and may not advertise to conduct, any training, testing, and checking...

  18. 14 CFR 141.23 - Advertising limitations.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Advertising limitations. 141.23 Section 141...) SCHOOLS AND OTHER CERTIFICATED AGENCIES PILOT SCHOOLS General § 141.23 Advertising limitations. (a) The... certificate may not advertise that the school is certificated unless it clearly differentiates between...

  19. Back to Classics: Teaching Limits through Infinitesimals.

    Science.gov (United States)

    Todorov, Todor D.

    2001-01-01

    Criticizes the method of using calculators for the purpose of selecting candidates for L, for the limit value of a function. Suggests an alternative: a working formula for calculating the limit value L of a real function in terms of infinitesimals. (Author/ASK)

  20. A singular limit for compressible rotating fluids

    CERN Document Server

    Feireisl, Eduard; Novotny, Antonin

    2010-01-01

    We consider a singular limit problem for the Navier-Stokes system of a rotating compressible fluid, where the Rossby and Mach numbers tend simultaneously to zero. The limit problem is identified as the 2-D Navier-Stokes system in the ``horizontal'' variables containing an extra term that accounts for compressibility in the original system.