WorldWideScience

Sample records for bioscience grand challenge

  1. The interfacial bioscience grand challenge.

    Energy Technology Data Exchange (ETDEWEB)

    Lane, Pamela; Stevens, Mark Jackson; Jacobsen, Richard B.; Hong, Joohee; Ayson, Marites J.; Crozier, Paul Stewart; Wood, Nichole L.; Schoeniger, Joseph S.; Kruppa, Gary Hermann; Sale, Kenneth L.; Young, Malin M.; Faulon, Jean-Loup Michel; Burns, Alan Richard; Evans, Kervin O.; Novak, Petr

    2004-03-01

    This report is broken down into the following 3 sections: (1) Chemical Cross-linking and Mass Spectrometry Applied to Determination of Protein Structure and Dynamics; (2) Computational Modeling of Membrane Protein Structure and Dynamics; and (3) Studies of Toxin-Membrane Interactions using Single Molecule Biophysical Methods.

  2. Challenges in Understanding Photosynthesis in a University Introductory Biosciences Class

    Science.gov (United States)

    Södervik, Ilona; Virtanen, Viivi; Mikkilä-Erdmann, Mirjamaija

    2015-01-01

    University students' understanding of photosynthesis was examined in a large introductory biosciences class. The focus of this study was to first examine the conceptions of photosynthesis among students in class and then to investigate how a certain type of text could enhance students' understanding of photosynthesis. The study was based on pre-…

  3. Grand Challenges of Enterprise Integration

    Energy Technology Data Exchange (ETDEWEB)

    Brosey, W.D; Neal, R.E.; Marks, D.

    2001-04-01

    Enterprise Integration connects and combines people, processes, systems, and technologies to ensure that the right people and the right processes have the right information and the right resources at the right time. A consensus roadmap for Technologies for Enterprise Integration was created as part of an industry/government/academia partnership in the Integrated Manufacturing Technology Initiative (IMTI). Two of the grand challenges identified by the roadmapping effort will be addressed here--Customer Responsive Enterprises and Totally Connected Enterprises. Each of these challenges is briefly discussed as to the current state of industry and the future vision as developed in the roadmap.

  4. Grand challenges for biological engineering.

    Science.gov (United States)

    Yoon, Jeong-Yeol; Riley, Mark R

    2009-09-22

    Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE) released a document "Grand Challenges in Engineering," covering broad realms of human concern from sustainability, health, vulnerability and the joy of living. Biological engineers, having tools and techniques at the interface between living and non-living entities, will play a prominent role in forging a better future. The 2010 Institute of Biological Engineering (IBE) conference in Cambridge, MA, USA will address, in part, the roles of biological engineering in solving the challenges presented by the NAE. This letter presents a brief outline of how biological engineers are working to solve these large scale and integrated problems of our society.

  5. Grand challenges for biological engineering

    Directory of Open Access Journals (Sweden)

    Riley Mark R

    2009-09-01

    Full Text Available Abstract Biological engineering will play a significant role in solving many of the world's problems in medicine, agriculture, and the environment. Recently the U.S. National Academy of Engineering (NAE released a document "Grand Challenges in Engineering," covering broad realms of human concern from sustainability, health, vulnerability and the joy of living. Biological engineers, having tools and techniques at the interface between living and non-living entities, will play a prominent role in forging a better future. The 2010 Institute of Biological Engineering (IBE conference in Cambridge, MA, USA will address, in part, the roles of biological engineering in solving the challenges presented by the NAE. This letter presents a brief outline of how biological engineers are working to solve these large scale and integrated problems of our society.

  6. Coordinated Exploration for Grand Challenges

    DEFF Research Database (Denmark)

    Ørding Olsen, Anders; Sofka, Wolfgang; Grimpe, Christoph

    2016-01-01

    Grand challenges are among the most complex problems for modern societies. Many governments and foundations provide substantial resources to encourage the search for solutions. Due to the significance of these problems, organizations often form partnerships in what we call search consortia...... to engage in joint search and compete for funding. Prior research on joint search highlights the role of specialized organizations, mainly regarding technological domains, to identify a superior solution. However, stakeholder theory leads us to believe that the success of any solution depends...... on the acceptance and support of important stakeholders. In this study, we suggest that search consortia are more likely to receive funding when they include representatives of stakeholder concerns, so-called advocacy groups. We extend theory on coordinated exploration in joint search by integrating mechanisms from...

  7. Plasma nanoscience: setting directions, tackling grand challenges

    Energy Technology Data Exchange (ETDEWEB)

    Ostrikov, Kostya [Plasma Nanoscience Centre Australia (PNCA), CSIRO Materials Science and Engineering, PO Box 218, Lindfield NSW 2070 (Australia); Cvelbar, Uros [Jozef Stefan Institute, 39 Jamova cesta, Ljubljana, SI-1000 (Slovenia); Murphy, Anthony B, E-mail: Kostya.Ostrikov@csiro.au, E-mail: Uros.Cvelbar@ijs.si, E-mail: Tony.Murphy@csiro.au [CSIRO Materials Science and Engineering, PO Box 218, Lindfield NSW 2070 (Australia)

    2011-05-04

    This review paper presents historical perspectives, recent advances and future directions in the multidisciplinary research field of plasma nanoscience. The current status and future challenges are presented using a three-dimensional framework. The first and the largest dimension covers the most important classes of nanoscale objects (nanostructures, nanofeatures and nanoassemblies/nanoarchitectures) and materials systems, namely carbon nanotubes, nanofibres, graphene, graphene nanoribbons, graphene nanoflakes, nanodiamond and related carbon-based nanostructures; metal, silicon and other inorganic nanoparticles and nanostructures; soft organic nanomaterials; nano-biomaterials; biological objects and nanoscale plasma etching. In the second dimension, we discuss the most common types of plasmas and plasma reactors used in nanoscale plasma synthesis and processing. These include low-temperature non-equilibrium plasmas at low and high pressures, thermal plasmas, high-pressure microplasmas, plasmas in liquids and plasma-liquid interactions, high-energy-density plasmas, and ionized physical vapour deposition as well as some other plasma-enhanced nanofabrication techniques. In the third dimension, we outline some of the 'Grand Science Challenges' and 'Grand Socio-economic Challenges' to which significant contributions from plasma nanoscience-related research can be expected in the near future. The urgent need for a stronger focus on practical, outcome-oriented research to tackle the grand challenges is emphasized and concisely formulated as from controlled complexity to practical simplicity in solving grand challenges.

  8. Plasma nanoscience: setting directions, tackling grand challenges

    Science.gov (United States)

    (Ken Ostrikov, Kostya; Cvelbar, Uros; Murphy, Anthony B.

    2011-05-01

    This review paper presents historical perspectives, recent advances and future directions in the multidisciplinary research field of plasma nanoscience. The current status and future challenges are presented using a three-dimensional framework. The first and the largest dimension covers the most important classes of nanoscale objects (nanostructures, nanofeatures and nanoassemblies/nanoarchitectures) and materials systems, namely carbon nanotubes, nanofibres, graphene, graphene nanoribbons, graphene nanoflakes, nanodiamond and related carbon-based nanostructures; metal, silicon and other inorganic nanoparticles and nanostructures; soft organic nanomaterials; nano-biomaterials; biological objects and nanoscale plasma etching. In the second dimension, we discuss the most common types of plasmas and plasma reactors used in nanoscale plasma synthesis and processing. These include low-temperature non-equilibrium plasmas at low and high pressures, thermal plasmas, high-pressure microplasmas, plasmas in liquids and plasma-liquid interactions, high-energy-density plasmas, and ionized physical vapour deposition as well as some other plasma-enhanced nanofabrication techniques. In the third dimension, we outline some of the 'Grand Science Challenges' and 'Grand Socio-economic Challenges' to which significant contributions from plasma nanoscience-related research can be expected in the near future. The urgent need for a stronger focus on practical, outcome-oriented research to tackle the grand challenges is emphasized and concisely formulated as from controlled complexity to practical simplicity in solving grand challenges.

  9. The Internet in developing nations: Grand challenges

    OpenAIRE

    Press, Larry

    2004-01-01

    This is a call for a "Grand Challenge" project for achieving truly global connectivity. For over a decade, we have hypothesized that the Internet could raise the quality of life in developing nations. We have conducted hundreds of studies of the state of the Internet and "e–readiness," done extensive training of technicians and policy makers, run pilot studies, and held local, regional and global conferences and workshops. After all of this activity, Internet connectivity is nearly non–existe...

  10. Grand challenges in protoplanetary disc modelling

    CERN Document Server

    Haworth, Thomas J; Forgan, Duncan H; Facchini, Stefano; Price, Daniel J; authors, Community; Boneberg, Dominika M; Booth, Richard A; Gonzalez, Jean-François; Hutchison, Mark A; Laibe, Guillaume; Meru, Farzana; Mohanty, Subhanjoy; Panić, Olja; Rice, Ken; Walsh, Catherine; Woitke, Peter

    2016-01-01

    The Protoplanetary Discussions conference --- held in Edinburgh, UK, from 7th-11th March 2016 --- included several open sessions led by participants. This paper reports on the discussions collectively concerned with the multiphysics modelling of protoplanetary discs, including the self-consistent calculation of gas and dust dynamics, radiative transfer and chemistry. After a short introduction to each of these disciplines in isolation, we identify a series of burning questions and grand challenges associated with their integration, which are not necessarily achievable in the short-to-medium term. We then discuss potential pathways towards solving these challenges, grouped by strategical, technical and collaborative developments. This paper is not intended to be a review, but rather to motivate and direct future research and collaboration across typically distinct fields based on community driven input, to encourage further progress in our understanding of circumstellar and protoplanetary discs.

  11. Grand Challenges in Protoplanetary Disc Modelling

    Science.gov (United States)

    Haworth, Thomas J.; Ilee, John D.; Forgan, Duncan H.; Facchini, Stefano; Price, Daniel J.; Boneberg, Dominika M.; Booth, Richard A.; Clarke, Cathie J.; Gonzalez, Jean-François; Hutchison, Mark A.; Kamp, Inga; Laibe, Guillaume; Lyra, Wladimir; Meru, Farzana; Mohanty, Subhanjoy; Panić, Olja; Rice, Ken; Suzuki, Takeru; Teague, Richard; Walsh, Catherine; Woitke, Peter; Community authors

    2016-10-01

    The Protoplanetary Discussions conference-held in Edinburgh, UK, from 2016 March 7th-11th-included several open sessions led by participants. This paper reports on the discussions collectively concerned with the multi-physics modelling of protoplanetary discs, including the self-consistent calculation of gas and dust dynamics, radiative transfer, and chemistry. After a short introduction to each of these disciplines in isolation, we identify a series of burning questions and grand challenges associated with their continuing development and integration. We then discuss potential pathways towards solving these challenges, grouped by strategical, technical, and collaborative developments. This paper is not intended to be a review, but rather to motivate and direct future research and collaboration across typically distinct fields based on community-driven input, to encourage further progress in our understanding of circumstellar and protoplanetary discs.

  12. The ten grand challenges of synthetic life.

    Science.gov (United States)

    Porcar, Manuel; Danchin, Antoine; de Lorenzo, Victor; Dos Santos, Vitor A; Krasnogor, Natalio; Rasmussen, Steen; Moya, Andrés

    2011-06-01

    The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life in the lab.

  13. Observational Needs from the WCRP Grand Challenges

    Science.gov (United States)

    Carlson, David

    2016-07-01

    An innovative history of platforms and instruments has provided remarkable satellite-based views of and data about our planet over roughly the past 35 years. The fragile and temporary nature of these satellite systems remind us that, from a climate viewpoint, we have not in any way solved or completed our observational tasks. Instead, the challenges of using satellites to observe key features of our planet's climate grow more complicated and the need grows more urgent. Admitting that we have borrowed and adopted some of our current capabilities from meteorological satellites, we need continuity of what we have as well as innovation and extension to reach new features that we now recognise as important. The scientific goals of the WCRP Grand Challenges emphasise this simultaneous need for continuation and innovation. We need longer better records of global changes in cloud types and distributions but we also need sharp accurate views of water vapour beneath those clouds. We need gravity missions to continue to track the net mass losses from Greenland and Antarctica while at the same time we need innovative remote sensing techniques to quantify rapid ice discharges at their peripheries. We need longer and broader latitudinal records of precipitation, snow cover and soil moisture but we also crucially need to detect hydrological and biogeochemical processes at the root zone. We must maintain continuity and consistency of ocean surface temperature, surface salinity and surface wind records while we also develop new methods to reveal and record deep ocean temperatures and currents. For immediate scientific, economic and political reasons we must develop a comprehensive CO2 monitoring system. And we need open high-quality access to all these data to understand present and preceding conditions as we encounter the surprises of the Anthropocene.

  14. The ten grand challenges of synthetic life

    NARCIS (Netherlands)

    Porcar, M.; Danchin, A.; Lorenzo, de V.; Martins Dos Santos, V.A.P.; Krasnogor, V.; Rasmussen, S.; Moya, A.

    2011-01-01

    The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental sc

  15. New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences.

    Science.gov (United States)

    Hood, Leroy E; Omenn, Gilbert S; Moritz, Robert L; Aebersold, Ruedi; Yamamoto, Keith R; Amos, Michael; Hunter-Cevera, Jennie; Locascio, Laurie

    2012-09-01

    This White Paper sets out a Life Sciences Grand Challenge for Proteomics Technologies to enhance our understanding of complex biological systems, link genomes with phenotypes, and bring broad benefits to the biosciences and the US economy. The paper is based on a workshop hosted by the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, 14-15 February 2011, with participants from many federal R&D agencies and research communities, under the aegis of the US National Science and Technology Council (NSTC). Opportunities are identified for a coordinated R&D effort to achieve major technology-based goals and address societal challenges in health, agriculture, nutrition, energy, environment, national security, and economic development.

  16. Workshop and conference on Grand Challenges applications and software technology

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-31

    On May 4--7, 1993, nine federal agencies sponsored a four-day meeting on Grand Challenge applications and software technology. The objective was to bring High-Performance Computing and Communications (HPCC) Grand Challenge applications research groups supported under the federal HPCC program together with HPCC software technologists to: discuss multidisciplinary computational science research issues and approaches, identify major technology challenges facing users and providers, and refine software technology requirements for Grand Challenge applications research. The first day and a half focused on applications. Presentations were given by speakers from universities, national laboratories, and government agencies actively involved in Grand Challenge research. Five areas of research were covered: environmental and earth sciences; computational physics; computational biology, chemistry, and materials sciences; computational fluid and plasma dynamics; and applications of artificial intelligence. The next day and a half was spent in working groups in which the applications researchers were joined by software technologists. Nine breakout sessions took place: I/0, Data, and File Systems; Parallel Programming Paradigms; Performance Characterization and Evaluation of Massively Parallel Processing Applications; Program Development Tools; Building Multidisciplinary Applications; Algorithm and Libraries I; Algorithms and Libraries II; Graphics and Visualization; and National HPCC Infrastructure.

  17. Grand challenges in space synthetic biology

    OpenAIRE

    Menezes, Amor A.; Montague, Michael G.; Cumbers, John; Hogan, John A.; Arkin, Adam P.

    2015-01-01

    Space synthetic biology is a branch of biotechnology dedicated to engineering biological systems for space exploration, industry and science. There is significant public and private interest in designing robust and reliable organisms that can assist on long-duration astronaut missions. Recent work has also demonstrated that such synthetic biology is a feasible payload minimization and life support approach as well. This article identifies the challenges and opportunities that lie ahead in the...

  18. Grand challenges in space synthetic biology.

    Science.gov (United States)

    Menezes, Amor A; Montague, Michael G; Cumbers, John; Hogan, John A; Arkin, Adam P

    2015-12-06

    Space synthetic biology is a branch of biotechnology dedicated to engineering biological systems for space exploration, industry and science. There is significant public and private interest in designing robust and reliable organisms that can assist on long-duration astronaut missions. Recent work has also demonstrated that such synthetic biology is a feasible payload minimization and life support approach as well. This article identifies the challenges and opportunities that lie ahead in the field of space synthetic biology, while highlighting relevant progress. It also outlines anticipated broader benefits from this field, because space engineering advances will drive technological innovation on Earth.

  19. Scaling up Social: Strategies for Solving Social Work's Grand Challenges

    Science.gov (United States)

    Rodriguez, Maria Y.; Ostrow, Laysha; Kemp, Susan P.

    2017-01-01

    The Grand Challenges for Social Work Initiative aims to focus the profession's attention on how social work can play a larger role in mitigating contemporary social problems. Yet a central issue facing contemporary social work is its seeming reticence to engage with social problems, and their solutions, beyond individual-level interventions.…

  20. Grand Challenges in Measuring and Characterizing Scholarly Impact

    OpenAIRE

    Chen, Chaomei

    2016-01-01

    The constantly growing body of scholarly knowledge of science, technology, and humanities is an asset of the mankind. While new discoveries expand the existing knowledge, they may simultaneously render some of it obsolete. It is crucial for scientists and other stakeholders to keep their knowledge up to date. Policy makers, decision makers, and the general public also need an efficient communication of scientific knowledge. Several grand challenges concerning the creation, adaptation, and dif...

  1. Grand challenges in bioengineered nanorobotics for cancer therapy.

    Science.gov (United States)

    Lenaghan, Scott C; Wang, Yongzhong; Xi, Ning; Fukuda, Toshio; Tarn, Tzyhjong; Hamel, William R; Zhang, Mingjun

    2013-03-01

    One of the grand challenges currently facing engineering, life sciences, and medicine is the development of fully functional nanorobots capable of sensing, decision making, and actuation. These nanorobots may aid in cancer therapy, site-specific drug delivery, circulating diagnostics, advanced surgery, and tissue repair. In this paper, we will discuss, from a bioinspired perspective, the challenges currently facing nanorobotics, including core design, propulsion and power generation, sensing, actuation, control, decision making, and system integration. Using strategies inspired from microorganisms, we will discuss a potential bioengineered nanorobot for cancer therapy.

  2. Is it possible to give scientific solutions to Grand Challenges? On the idea of grand challenges for life science research.

    Science.gov (United States)

    Efstathiou, Sophia

    2016-04-01

    This paper argues that challenges that are grand in scope such as "lifelong health and wellbeing", "climate action", or "food security" cannot be addressed through scientific research only. Indeed scientific research could inhibit addressing such challenges if scientific analysis constrains the multiple possible understandings of these challenges into already available scientific categories and concepts without translating between these and everyday concerns. This argument builds on work in philosophy of science and race to postulate a process through which non-scientific notions become part of science. My aim is to make this process available to scrutiny: what I call founding everyday ideas in science is both culturally and epistemologically conditioned. Founding transforms a common idea into one or more scientifically relevant ones, which can be articulated into descriptively thicker and evaluatively deflated terms and enable operationalisation and measurement. The risk of founding however is that it can invisibilise or exclude from realms of scientific scrutiny interpretations that are deemed irrelevant, uninteresting or nonsensical in the domain in question-but which may remain salient for addressing grand-in-scope challenges. The paper considers concepts of "wellbeing" in development economics versus in gerontology to illustrate this process.

  3. Bringing Seismology's Grand Challenges to the Undergraduate Classroom

    Science.gov (United States)

    Benoit, M. H.; Taber, J.; Hubenthal, M.

    2011-12-01

    The "Seismological Grand Challenges in Understanding Earth's Dynamic Systems," a community-written long-range science plan for the next decade, poses 10 questions to guide fundamental seismological research. Written in an approachable fashion suitable for policymakers, the broad questions and supporting discussion contained in this document offer an ideal framework for the development of undergraduate curricular materials. Leveraging this document, we have created a collection of inquiry-based classroom modules that utilize authentic data to modernize seismological instruction in 100 and 200 level undergraduate courses. The modules not only introduce undergraduates to the broad questions that the seismological community seeks to answer in the future but also showcase the numerous areas where modern seismological research is actively contributing to our understanding of fundamental Earth processes. To date 6 in-depth explorations that correspond to the Grand Challenges document have been developed. The specific topics for each exploration were selected to showcase modern seismological research while also covering topics commonly included in the curriculum of these introductory classes. Examples of activities that have been created and their corresponding Grand Challenge include: -A guided inquiry that introduces students to episodic tremor and slip and compares the GPS and seismic signatures of ETS with those produced from standard tectonic earthquakes (Grand Challenge "How do faults slip?"). - A laboratory exercise where students engage in b-value mapping of volcanic earthquakes to assess potential eruption hazards (How do magmas ascend and erupt?). - A module that introduce students to glacial earthquakes in Greenland and compares their frequency and spatial distribution to tectonic earthquakes (How do processes in the ocean and atmosphere interact with the solid Earth?). What is the relationship between stress and strain in the lithosphere? - An activity that

  4. First-Year Students' Attitudes towards the Grand Challenges and Nanotechnology

    Science.gov (United States)

    Lakin, Joni M.; Han, Yi; Davis, Edward

    2016-01-01

    The "Grand Challenges" for Engineering are an effort to portray engineering as a field that has profound impacts on society. This study explores the level of interest first-year engineering students had in various "Grand Challenges" and in nanotechnology topics. We administered a survey to a large sample of students enrolled in…

  5. The MICE Grand Challenge Lightcone Simulation I: Dark matter clustering

    CERN Document Server

    Fosalba, P; Gaztanaga, E; Castander, F J

    2013-01-01

    We present a new N-body simulation from the MICE collaboration, the MICE Grand Challenge (MICE-GC), containing about 70 billion dark-matter particles in a (3 Gpc/h)^3 comoving volume. Given its large volume and fine spatial resolution, spanning over 5 orders of magnitude in dynamic range, it allows an accurate modeling of the growth of structure in the universe from the linear through the highly non-linear regime of gravitational clustering. We validate the dark-matter simulation outputs using 3D and 2D clustering statistics, and discuss mass-resolution effects in the non-linear regime by comparing to previous simulations and the latest numerical fits. We show that the MICE-GC run allows for a measurement of the BAO feature with percent level accuracy and compare it to state-of-the-art theoretical models. We also use sub-arcmin resolution pixelized 2D maps of the dark-matter counts in the lightcone to make tomographic analyses in real and redshift space. Our analysis shows the simulation reproduces the Kaiser...

  6. The MICE grand challenge lightcone simulation - I. Dark matter clustering

    Science.gov (United States)

    Fosalba, P.; Crocce, M.; Gaztañaga, E.; Castander, F. J.

    2015-04-01

    We present a new N-body simulation from the Marenostrum Institut de Ciències de l'Espai (MICE) collaboration, the MICE Grand Challenge (MICE-GC), containing about 70 billion dark matter particles in a (3 Gpc h-1)3 comoving volume. Given its large volume and fine spatial resolution, spanning over five orders of magnitude in dynamic range, it allows an accurate modelling of the growth of structure in the universe from the linear through the highly non-linear regime of gravitational clustering. We validate the dark matter simulation outputs using 3D and 2D clustering statistics, and discuss mass-resolution effects in the non-linear regime by comparing to previous simulations and the latest numerical fits. We show that the MICE-GC run allows for a measurement of the BAO feature with per cent level accuracy and compare it to state-of-the-art theoretical models. We also use sub-arcmin resolution pixelized 2D maps of the dark matter counts in the lightcone to make tomographic analyses in real and redshift space. Our analysis shows the simulation reproduces the Kaiser effect on large scales, whereas we find a significant suppression of power on non-linear scales relative to the real space clustering. We complete our validation by presenting an analysis of the three-point correlation function in this and previous MICE simulations, finding further evidence for mass-resolution effects. This is the first of a series of three papers in which we present the MICE-GC simulation, along with a wide and deep mock galaxy catalogue built from it. This mock is made publicly available through a dedicated web portal, http://cosmohub.pic.es.

  7. Biological approaches for addressing the grand challenge of providing access to clean drinking water

    OpenAIRE

    Gerba Charles P; Riley Mark R; Elimelech Menachem

    2011-01-01

    Abstract The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of p...

  8. Grand challenge problems in environmental modeling and remediation: Groundwater contaminant transport. Final project report 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-04-01

    The over-reaching goal of the Groundwater Grand Challenge component of the Partnership in Computational Science (PICS) was to develop and establish the massively parallel approach for the description of groundwater flow and transport and to address the problem of uncertainties in the data and its interpretation. This necessitated the development of innovative algorithms and the implementation of massively parallel computational tools to provide a suite of simulators for groundwater flow and transport in heterogeneous media. This report summarizes the activities and deliverables of the Groundwater Grand Challenge project funded through the High Performance Computing grand challenge program of the Department of Energy from 1995 through 1997.

  9. Grand challenges in the management and conservation of North American inland fishes and fisheries

    Science.gov (United States)

    Lynch, Abigail; Cooke, Steven J.; Beard, Douglas; Kao, Yu-Chun; Lorenzen, Kai; Song, Andrew M.; Allen, Micheal S.; Basher, Zeenatul; Bunnell, David; Camp, Edward V.; Cowx, Ian G.; Freedman, Jonathan A.; Nguyen, Vivian M.; Nohner, Joel K.; Rogers, Mark W.; Siders, Zachary A.; Taylor, William W.; Youn, So-Jung

    2017-01-01

    Even with long-standing management and extensive science support, North American inland fish and fisheries still face many conservation and management challenges. We used a grand challenges approach to identify critical roadblocks that if removed would help solve important problems in the management and long-term conservation of North American inland fish and fisheries. We identified seven grand challenges within three themes (valuation, governance, and externalities) and 34 research needs and management actions. The major themes identified are to (1) raise awareness of diverse values associated with inland fish and fisheries, (2) govern inland fish and fisheries to satisfy multiple use and conservation objectives, and (3) ensure productive inland fisheries given nonfishing sector externalities. Addressing these grand challenges will help the broader community understand the diverse values of inland fish and fisheries, promote open forums for engagement of diverse stakeholders in fisheries management, and better integrate the inland fish sector into the greater water and land use policy process.

  10. A Library in the Grands Moulins de Paris: challenging Reality

    Directory of Open Access Journals (Sweden)

    Catherine Tresson

    2006-07-01

    Full Text Available In 2006, the University of Paris 7 and its new Main Library will move to Paris Rive Gauche, a recently developed neighbourhood on the left bank of the Seine. The library will occupy most of the city’s former industrial mills, the Grands Moulins de Paris. As part of the project, the library developed a very detailed functional program. The facilities are expected to comprise 1,800 workstations (half of which will be computerized, and upon completion will have a capacity of 300,000 freely accessible documents and 350,000 documents in store over a total surface area of some 12,000 m2. The architect Rudy Ricciotti won the international competition to design the library held in 2001. Perfectly suited to its function, the industrial building in which the library is housed dates from the 1920s. It presents both advantages (vast surfaces, sufficient load-bearing capacity, natural light, etc. and obstacles (restrictions on free circulation, forests of columns in certain areas, interrupted spaces, etc. to being transformed into a library that is functional and adapted to its purposes. The building’s structure and the constraints it imposed profoundly influenced the program which had to be adjusted, and also affected other aspects, including the arrangement and features of the furnishings as well as the building’s system of signs. In agreement with the university, the library worked in close collaboration with the architect from the earliest sketches onwards. As a result, his initial plan also evolved considerably. The installation of the library in the Grands Moulins offers us a chance to observe the nature and effects of the interactions between the transformation of a building and the evolution of a program.

  11. Grand challenge commentary: Transforming biosynthesis into an information science.

    Science.gov (United States)

    Bayer, Travis S

    2010-12-01

    Engineering biosynthetic pathways to natural products is a challenging endeavor that promises to provide new therapeutics and tools to manipulate biology. Information-guided design strategies and tools could unlock the creativity of a wide spectrum of scientists and engineers by decoupling expertise from implementation.

  12. Grand challenge problems in environmental modeling and remediation: groundwater contaminant transport

    Energy Technology Data Exchange (ETDEWEB)

    Todd Arbogast; Steve Bryant; Clint N. Dawson; Mary F. Wheeler

    1998-08-31

    This report describes briefly the work of the Center for Subsurface Modeling (CSM) of the University of Texas at Austin (and Rice University prior to September 1995) on the Partnership in Computational Sciences Consortium (PICS) project entitled Grand Challenge Problems in Environmental Modeling and Remediation: Groundwater Contaminant Transport.

  13. Grand Challenges and Chemical Engineering Curriculum--Developments at TU Dortmund University

    Science.gov (United States)

    Kockmann, Norbert; Lutze, Philip; Gorak, Andrzej

    2016-01-01

    Chemical processing industry is progressively focusing their research activities and product placements in the areas of Grand Challenges (or Global Megatrends) such as mobility, energy, communication, or health care and food. Innovation in all these fields requires solving high complex problems, rapid product development as well as dealing with…

  14. Megatrends and grand challenges of cybercrime and cyberterrorism policy and research

    NARCIS (Netherlands)

    Koops, Bert Jaap; Akhgar, Babak; Brewster, Ben

    2016-01-01

    What are grand challenges of cybercrime and cyberterrorism policy and research for the coming one or two decades? To answer this question, we first need to grasp some major trends that influence the future of cybercrime and cyberterrorism, and the combatting thereof, in fundamental ways. This chapte

  15. Using Grand Challenges For Innovative Teaching in Structural Geology, Geophysics, and Tectonics

    Science.gov (United States)

    McDaris, J. R.; Tewksbury, B. J.; Wysession, M. E.

    2012-12-01

    An innovative approach to teaching involves using the "Big Ideas" or "Grand Challenges" of a field, as determined by the research community in that area, as the basis for classroom activities. There have been several recent efforts in the areas of structural geology, tectonics, and geophysics to determine these Grand Challenges, including the areas of seismology ("Seismological Grand Challenges in Understanding Earth's Dynamic Systems"), mineral physics ("Unlocking the Building Blocks of the Planet"), EarthScope-related science ("Unlocking the Secrets of the North American Continent: An EarthScope Science Plan for 2010-2020"), and structural geology and tectonics (at the Structural Geology and Tectonics Forum held at Williams College in June, 2012). These research community efforts produced frameworks of the essential information for their fields with the aim of guiding future research. An integral part of this, however, is training the next generation of scientists, and using these Big Ideas as the basis for course structures and activities is a powerful way to make this happen. When activities, labs, and homeworks are drawn from relevant and cutting-edge research topics, students can find the material more fascinating and engaging, and can develop a better sense of the dynamic process of scientific discovery. Many creative ideas for incorporating the Grand Challenges of structural geology, tectonics, and geophysics in the classroom were developed at a Cutting Edge workshop on "Teaching Structural Geology, Geophysics, and Tectonics in the 21st Century" held at the University of Tennessee in July, 2012.

  16. Biofuels and Sustainable Development: An Executive Session on the Grand Challenges of the Sustainability Transition

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Henry [Harvard Univ., Cambridge, MA (United States); Clark, William C. [Harvard Univ., Cambridge, MA (United States); Devereaux, Charan [Harvard Univ., Cambridge, MA (United States)

    2008-05-20

    This report is the result of the second in a series of intense workshops and study sessions on Grand Challenges of the Sustainability Transition, organized by the Sustainability Science Program at Harvard University, hosted by Venice International University, and supported by the Italian Ministry of Environment, Land and Sea.

  17. Promoting Collaborative Problem-Solving Skills in a Course on Engineering Grand Challenges

    Science.gov (United States)

    Zou, Tracy X. P.; Mickleborough, Neil C.

    2015-01-01

    The ability to solve problems with people of diverse backgrounds is essential for engineering graduates. A course on engineering grand challenges was designed to promote collaborative problem-solving (CPS) skills. One unique component is that students need to work both within their own team and collaborate with the other team to tackle engineering…

  18. Grand challenge problem 12: Assessing student learning through continuous collection and interpretation of temporal performance data

    NARCIS (Netherlands)

    Molenaar, I.; Wise, A.F.

    2016-01-01

    Learning and assessment have traditionally occurred as distinct activities, where engaging in one takes time away from the other. This grand challenge explores how advances in data collection and analysis can be leveraged to integrate learning and assessment in one single process. Developing assessm

  19. Biological approaches for addressing the grand challenge of providing access to clean drinking water.

    Science.gov (United States)

    Riley, Mark R; Gerba, Charles P; Elimelech, Menachem

    2011-03-31

    The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms.

  20. Biological approaches for addressing the grand challenge of providing access to clean drinking water

    Directory of Open Access Journals (Sweden)

    Gerba Charles P

    2011-03-01

    Full Text Available Abstract The U.S. National Academy of Engineering (NAE recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF. Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms.

  1. Using Grand Challenges to Teach Science: A Biology-Geology Collaboration

    Science.gov (United States)

    Lyford, M.; Myers, J. D.

    2012-12-01

    Three science courses at the University of Wyoming explore the inextricable connections between science and society by centering on grand challenges. Two of these courses are introductory integrated science courses for non-majors while the third is an upper level course for majors and non-majors. Through collaboration, the authors have developed these courses to explore the grand challenges of energy, water and climate. Each course focuses on the fundamental STEM principles required for a citizen to understand each grand challenge. However, the courses also emphasize the non-STEM perspectives (e.g., economics, politics, human well-being, externalities) that underlie each grand challenge and argue that creating equitable, sustainable and just solutions to the grand challenges hinges on an understanding of STEM and non-STEM perspectives. Moreover, the authors also consider the multitude of personal perspectives individuals bring to the classroom (e.g., values, beliefs, empathy misconceptions) that influence any stakeholder's ability to engage in fruitful discussions about grand challenge solutions. Discovering Science (LIFE 1002) focuses on the grand challenges of energy and climate. Students attend three one-hour lectures, one two-hour lab and a one-hour discussion each week. Lectures emphasize the STEM and non-STEM principles underlying each grand challenge. Laboratory activities are designed to be interdisciplinary and engage students in inquiry-driven activities to reinforce concepts from lecture and to model how science is conducted. Labs also expose students to the difficulties often associated with scientific studies, the limits of science, and the inherent uncertainties associated with scientific findings. Discussion sessions provide an opportunity for students to explore the complexity of the grand challenges from STEM and non-STEM perspectives, and expose the multitude of personal perspectives an individual might harbor related to each grand challenge

  2. Building a Course on Global Sustainability using the grand challenges of Energy-Water-Climate

    Science.gov (United States)

    Myers, J. D.

    2012-12-01

    GEOL1600: Global Sustainability: Managing the Earth's Resources is a lower division integrated science course at the University of Wyoming that fulfills the university's science requirement. Course content and context has been developed using the grand challenge nexus of energy-water-and climate (EWC). The interconnection of these issues, their social relevance and timeliness has provided a framework that gives students an opportunity to recognize why STEM is relevant to their lives regardless of their ultimate professional career choices. The EWC nexus provides the filter to sieve the course's STEM content. It also provides an ideal mechanism by which the non-STEM perspectives important in grand challenge solutions can be seamlessly incorporated in the course. Through a combination of content and context, the relevance of these issues engage students in their own learning. Development of the course followed the Grand Challenge Scientific Literacy (GCSL) model independently developed by the author and two colleagues at the University of Wyoming. This course model stresses science principles centered on the nature of science (e.g., fundamental premises, habits of mind, critical thinking) and unifying scientific concepts (e.g., methods and tools, experimentation, modeling). Grand challenge principles identify the STEM and non-STEM concepts needed to understand the grand challenges, drawing on multiple STEM and non-STEM disciplines and subjects (i.e., economics, politics, unintended consequences, roles of stakeholders). Using the EWC nexus filter and building on the Grand Challenge Principles, specific content included in the course is selected is that most relevant to understanding the Grand Challenges, thereby stressing content depth over breadth. Because quantitative data and reasoning is critical to effectively evaluating challenge solutions, QR is a component of nearly all class activities, while engineering and technology aspects of grand challenges are

  3. The grand challenge of managing the petascale facility.

    Energy Technology Data Exchange (ETDEWEB)

    Aiken, R. J.; Mathematics and Computer Science

    2007-02-28

    This report is the result of a study of networks and how they may need to evolve to support petascale leadership computing and science. As Dr. Ray Orbach, director of the Department of Energy's Office of Science, says in the spring 2006 issue of SciDAC Review, 'One remarkable example of growth in unexpected directions has been in high-end computation'. In the same article Dr. Michael Strayer states, 'Moore's law suggests that before the end of the next cycle of SciDAC, we shall see petaflop computers'. Given the Office of Science's strong leadership and support for petascale computing and facilities, we should expect to see petaflop computers in operation in support of science before the end of the decade, and DOE/SC Advanced Scientific Computing Research programs are focused on making this a reality. This study took its lead from this strong focus on petascale computing and the networks required to support such facilities, but it grew to include almost all aspects of the DOE/SC petascale computational and experimental science facilities, all of which will face daunting challenges in managing and analyzing the voluminous amounts of data expected. In addition, trends indicate the increased coupling of unique experimental facilities with computational facilities, along with the integration of multidisciplinary datasets and high-end computing with data-intensive computing; and we can expect these trends to continue at the petascale level and beyond. Coupled with recent technology trends, they clearly indicate the need for including capability petascale storage, networks, and experiments, as well as collaboration tools and programming environments, as integral components of the Office of Science's petascale capability metafacility. The objective of this report is to recommend a new cross-cutting program to support the management of petascale science and infrastructure. The appendices of the report document current and projected

  4. Synchrotron radiation in biosciences

    Science.gov (United States)

    Marinkovic, Nebojsa S.; Gupta, Sayan; Zhan, Chenyang; Chance, Mark R.

    2005-12-01

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  5. Synchrotron radiation in biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Marinkovic, Nebojsa S. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)]. E-mail: marinkov@bnl.gov; Gupta, Sayan [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Zhan, Chenyang [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States); Chance, Mark R. [Center for Synchrotron Biosciences, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 315, Bronx, NY 10461 (United States)

    2005-12-15

    The Center for Synchrotron Biosciences (CSB) operates five beamlines at the National Synchrotron Light Source (NSLS). Infrared (IR) micro-spectroscopy, X-ray absorption spectroscopy, structural proteomics and macromolecular footprinting are among the major technologies available through the Center. IR micro-spectroscopy is used to examine protein-folding in the microsecond time regime, image bone, neurons, seeds and other biological tissues, as well as image samples of interest in the chemical and environmental sciences. Structural proteomics research of New York Structural Genomics Research Consortium (NYSGRC) is steadily increasing the number of solved protein structures, with a goal to solve 100-200 structures per year. To speed up the research, a high-throughput method called 'metallomics' was implemented for NYSGRC crystallographers to detect intrinsic anomalous scatterers using X-ray absorption spectroscopy. Hydroxyl radical mediated X-ray footprinting is capable of resolving folding events of RNA, at single base resolution on millisecond timescales using a synchrotron white beam. The high brightness of synchrotron source is essential for CSB projects as it permits the use of smaller sample sizes and/or concentration, and allows studies of more complicated biological systems than with conventional sources.

  6. A Grand Challenge: Immortal Information and Through-Life Knowledge Management (KIM

    Directory of Open Access Journals (Sweden)

    Alexander Ball

    2006-11-01

    Full Text Available ‘Immortal information and through-life knowledge management: strategies and tools for the emerging product-service business paradigm’, is a Grand Challenge project involving eleven different UK universities and incorporating substantial industry collaboration. It is investigating a range of issues associated with the move towards a product-service paradigm in the engineering sector, in particular the long-term curation of digital data, learning from production and use, and appropriate governance and management techniques.

  7. A Federal Vision for Future Computing: A Nanotechnology-Inspired Grand Challenge

    Science.gov (United States)

    2016-07-29

    academia to explore new methods on neuromorphic and quantum D-Wave processors. Discovering and creating brain-like algorithms is an important area to be...Nanotechnology-Inspired Grand Challenge 3 • Emerging computing architecture platforms, neuromorphic or quantum or others, that significantly accelerate... algorithm performance, concurrency, and performance execution while maintaining and/or reducing energy consumption by over six orders of magnitude

  8. The Internet in developing nations: Grand challenges (originally published in April 2004)

    OpenAIRE

    Press, Larry

    2007-01-01

    This is a call for a "Grand Challenge" project for achieving truly global connectivity. For over a decade, we have hypothesized that the Internet could raise the quality of life in developing nations. We have conducted hundreds of studies of the state of the Internet and "e–readiness," done extensive training of technicians and policy makers, run pilot studies, and held local, regional and global conferences and workshops. After all of this activity, Internet connectivity is nearly non–existe...

  9. Environmental Biosciences Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  10. D3R grand challenge 2015: Evaluation of protein-ligand pose and affinity predictions

    Science.gov (United States)

    Gathiaka, Symon; Liu, Shuai; Chiu, Michael; Yang, Huanwang; Stuckey, Jeanne A.; Kang, You Na; Delproposto, Jim; Kubish, Ginger; Dunbar, James B.; Carlson, Heather A.; Burley, Stephen K.; Walters, W. Patrick; Amaro, Rommie E.; Feher, Victoria A.; Gilson, Michael K.

    2016-09-01

    The Drug Design Data Resource (D3R) ran Grand Challenge 2015 between September 2015 and February 2016. Two targets served as the framework to test community docking and scoring methods: (1) HSP90, donated by AbbVie and the Community Structure Activity Resource (CSAR), and (2) MAP4K4, donated by Genentech. The challenges for both target datasets were conducted in two stages, with the first stage testing pose predictions and the capacity to rank compounds by affinity with minimal structural data; and the second stage testing methods for ranking compounds with knowledge of at least a subset of the ligand-protein poses. An additional sub-challenge provided small groups of chemically similar HSP90 compounds amenable to alchemical calculations of relative binding free energy. Unlike previous blinded Challenges, we did not provide cognate receptors or receptors prepared with hydrogens and likewise did not require a specified crystal structure to be used for pose or affinity prediction in Stage 1. Given the freedom to select from over 200 crystal structures of HSP90 in the PDB, participants employed workflows that tested not only core docking and scoring technologies, but also methods for addressing water-mediated ligand-protein interactions, binding pocket flexibility, and the optimal selection of protein structures for use in docking calculations. Nearly 40 participating groups submitted over 350 prediction sets for Grand Challenge 2015. This overview describes the datasets and the organization of the challenge components, summarizes the results across all submitted predictions, and considers broad conclusions that may be drawn from this collaborative community endeavor.

  11. Docking-undocking combination applied to the D3R Grand Challenge 2015

    Science.gov (United States)

    Ruiz-Carmona, Sergio; Barril, Xavier

    2016-09-01

    Novel methods for drug discovery are constantly under development and independent exercises to test and validate them for different goals are extremely useful. The drug discovery data resource (D3R) Grand Challenge 2015 offers an excellent opportunity as an external assessment and validation experiment for Computer-Aided Drug Discovery methods. The challenge comprises two protein targets and prediction tests: binding mode and ligand ranking. We have faced both of them with the same strategy: pharmacophore-guided docking followed by dynamic undocking (a new method tested experimentally here) and, where possible, critical assessment of the results based on pre-existing information. In spite of using methods that are qualitative in nature, our results for binding mode and ligand ranking were amongst the best on Hsp90. Results for MAP4K4 were less positive and we track the different performance across systems to the level of previous knowledge about accessible conformational states. We conclude that docking is quite effective if supplemented by dynamic undocking and empirical information (e.g. binding hot spots, productive protein conformations). This setup is well suited for virtual screening, a frequent application that was not explicitly tested in this edition of the D3R Grand Challenge 2015. Protein flexibility remains as the main cause for hard failures.

  12. Bio-TDS: bioscience query tool discovery system.

    Science.gov (United States)

    Gnimpieba, Etienne Z; VanDiermen, Menno S; Gustafson, Shayla M; Conn, Bill; Lushbough, Carol M

    2017-01-04

    Bioinformatics and computational biology play a critical role in bioscience and biomedical research. As researchers design their experimental projects, one major challenge is to find the most relevant bioinformatics toolkits that will lead to new knowledge discovery from their data. The Bio-TDS (Bioscience Query Tool Discovery Systems, http://biotds.org/) has been developed to assist researchers in retrieving the most applicable analytic tools by allowing them to formulate their questions as free text. The Bio-TDS is a flexible retrieval system that affords users from multiple bioscience domains (e.g. genomic, proteomic, bio-imaging) the ability to query over 12 000 analytic tool descriptions integrated from well-established, community repositories. One of the primary components of the Bio-TDS is the ontology and natural language processing workflow for annotation, curation, query processing, and evaluation. The Bio-TDS's scientific impact was evaluated using sample questions posed by researchers retrieved from Biostars, a site focusing on BIOLOGICAL DATA ANALYSIS: The Bio-TDS was compared to five similar bioscience analytic tool retrieval systems with the Bio-TDS outperforming the others in terms of relevance and completeness. The Bio-TDS offers researchers the capacity to associate their bioscience question with the most relevant computational toolsets required for the data analysis in their knowledge discovery process.

  13. Avoiding collapse: Grand challenges for science and society to solve by 2050

    Directory of Open Access Journals (Sweden)

    Anthony D. Barnosky

    2016-03-01

    Full Text Available Abstract We maintain that humanity’s grand challenge is solving the intertwined problems of human population growth and overconsumption, climate change, pollution, ecosystem destruction, disease spillovers, and extinction, in order to avoid environmental tipping points that would make human life more difficult and would irrevocably damage planetary life support systems. These are not future issues: for example, detrimental impacts of climate change (increased wildfires and extreme weather, sea-level rise, ocean acidification, pollution (contaminated drinking water in many parts of the world, rapid population growth in some areas (contributing to poverty, war, and increasingly frequent migration and overconsumption in others (a main driver of overexploitation of resources and greenhouse gas emissions, and new disease outbreaks (Ebola, Zika virus already are apparent today, and if trends of the past half century continue, even more damaging, long-lasting impacts would be locked in within three decades. Solving these problems will require some scientific and technological breakthroughs, but that will not be enough. Even more critical will be effective collaboration of environmental and physical scientists with social scientists and those in the humanities, active exchange of information among practitioners in academics, politics, religion, and business and other stakeholders, and clear communication of relevant issues and solutions to the general public. This special feature offers examples of how researchers are addressing this grand challenge through the process of discovering new knowledge and relevant tools, transferring insights across disciplinary boundaries, and establishing critical dialogues with those outside academia to help effect positive global change.

  14. Scientific Grand Challenges: Crosscutting Technologies for Computing at the Exascale - February 2-4, 2010, Washington, D.C.

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.

    2011-02-06

    The goal of the "Scientific Grand Challenges - Crosscutting Technologies for Computing at the Exascale" workshop in February 2010, jointly sponsored by the U.S. Department of Energy’s Office of Advanced Scientific Computing Research and the National Nuclear Security Administration, was to identify the elements of a research and development agenda that will address these challenges and create a comprehensive exascale computing environment. This exascale computing environment will enable the science applications identified in the eight previously held Scientific Grand Challenges Workshop Series.

  15. Grand Challenges for Biological and Environmental Research: A Long-Term Vision

    Energy Technology Data Exchange (ETDEWEB)

    Arkin, A.; Baliga, N.; Braam, J.; Church, G.; Collins, J; ; Cottingham, R.; Ecker, J.; Gerstein, M.; Gilna, P.; Greenberg, J.; Handelsman, J.; Hubbard, S.; Joachimiak, A.; Liao, J.; Looger, L.; Meyerowitz, E.; Mjolness, E.; Petsko, G.; Sayler, G.; Simpson, M.; Stacey, G.; Sussman, M.; Tiedje, J.; Bader, D.; Cessi, P.; Collins, W.; Denning, S.; Dickinson, R.; Easterling, D.; Edmonds, J.; Feddema, J.; Field, C.; Fridlind, A.; Fung, I.; Held, I.; Jackson, R.; Janetos, A.; Large, W.; Leinen, M.; Leung, R.; Long, S.; Mace, G.; Masiello, C.; Meehl, G.; Ort, D.; Otto-Bliesner, B.; Penner, J.; Prather, M.; Randall, D.; Rasch, P.; Schneider, E.; Shugart, H.; Thornton, P.; Washington, W.; Wildung, R.; Wiscombe, W.; Zak, D.; Zhang, M.; Bielicki, J.; Buford, M.; Cleland, E.; Dale, V.; Duke, C.; Ehleringer, J.; Hecht, A.; Kammen, D.; Marland, G.; Pataki, D.; Riley, M. Robertson, P.; Hubbard, S.

    2010-12-01

    outcomes and behaviors of complex biological and environmental systems, leading to robust solutions for DOE missions and strategic goals. In March 2010, the Biological and Environmental Research Advisory Committee held the Grand Challenges for Biological and Environmental Research: A Long-Term Vision workshop to identify scientific opportunities and grand challenges for BER science in the coming decades and to develop an overall strategy for drafting a long-term vision for BER. Key workshop goals included: (1) Identifying the greatest scientific challenges in biology, climate, and the environment that DOE will face over a 20-year time horizon. (2) Describing how BER should be positioned to address those challenges. (3) Determining the new and innovative tools needed to advance BER science. (4) Suggesting how the workforce of the future should be trained in integrative system science. This report lays out grand research challenges for BER - in biological systems, climate, energy sustainability, computing, and education and workforce training - that can put society on a path to achieve the scientific evidence and predictive understanding needed to inform decision making and planning to address future energy needs, climate change, water availability, and land use.

  16. 1st oPAC Topical Workshop: Grand Challenges in Accelerator Optimisation

    CERN Document Server

    2013-01-01

    Accelerators are key instruments for fundamental research, health and industry applications. International collaboration is very important for their continued optimisation. To address this oPAC is organising this two-day international workshop on Grand Challenges in Accelerator Optimisation. The workshop will provide an overview of the current state of the art in beam physics, numerical simulations and beam instrumentation and highlight existing limitations. It will discuss research and development being undertaken and ambitions to further improve the performance of existing and future facilities. In addition to invited talks, there will be industry displays and a special seminar covering recent LHC discoveries. All participants will have an opportunity to contribute a poster.

  17. Grand Challenges in the Physics of the Sun and Sun-like Stars

    CERN Document Server

    Thompson, Michael J

    2014-01-01

    The study of stellar structure and evolution is one of the main building blocks of astrophysics, and the Sun has an importance both as the star that is most amenable to detailed study and as the star that has by far the biggest impact on the Earth and near-Earth environment through its radiative and particulate outputs. Over the past decades, studies of stars and of the Sun have become somewhat separate. But in recent years, the rapid advances in asteroseismology, as well as the quest to better understand solar and stellar dynamos, have emphasized once again the synergy between studies of the stars and the Sun. In this article I have selected two "grand challenges" both for their crucial importance and because I thnk that these two problems are tractable to significant progress in the next decade. They are (i) understanding how solar and stellar dynamos generate magnetic field, and (ii) improving the predictability of geo-effective space weather.

  18. Network discovery, characterization, and prediction : a grand challenge LDRD final report.

    Energy Technology Data Exchange (ETDEWEB)

    Kegelmeyer, W. Philip, Jr.

    2010-11-01

    This report is the final summation of Sandia's Grand Challenge LDRD project No.119351, 'Network Discovery, Characterization and Prediction' (the 'NGC') which ran from FY08 to FY10. The aim of the NGC, in a nutshell, was to research, develop, and evaluate relevant analysis capabilities that address adversarial networks. Unlike some Grand Challenge efforts, that ambition created cultural subgoals, as well as technical and programmatic ones, as the insistence on 'relevancy' required that the Sandia informatics research communities and the analyst user communities come to appreciate each others needs and capabilities in a very deep and concrete way. The NGC generated a number of technical, programmatic, and cultural advances, detailed in this report. There were new algorithmic insights and research that resulted in fifty-three refereed publications and presentations; this report concludes with an abstract-annotated bibliography pointing to them all. The NGC generated three substantial prototypes that not only achieved their intended goals of testing our algorithmic integration, but which also served as vehicles for customer education and program development. The NGC, as intended, has catalyzed future work in this domain; by the end it had already brought in, in new funding, as much funding as had been invested in it. Finally, the NGC knit together previously disparate research staff and user expertise in a fashion that not only addressed our immediate research goals, but which promises to have created an enduring cultural legacy of mutual understanding, in service of Sandia's national security responsibilities in cybersecurity and counter proliferation.

  19. Prospective evaluation of shape similarity based pose prediction method in D3R Grand Challenge 2015

    Science.gov (United States)

    Kumar, Ashutosh; Zhang, Kam Y. J.

    2016-09-01

    Evaluation of ligand three-dimensional (3D) shape similarity is one of the commonly used approaches to identify ligands similar to one or more known active compounds from a library of small molecules. Apart from using ligand shape similarity as a virtual screening tool, its role in pose prediction and pose scoring has also been reported. We have recently developed a method that utilizes ligand 3D shape similarity with known crystallographic ligands to predict binding poses of query ligands. Here, we report the prospective evaluation of our pose prediction method through the participation in drug design data resource (D3R) Grand Challenge 2015. Our pose prediction method was used to predict binding poses of heat shock protein 90 (HSP90) and mitogen activated protein kinase kinase kinase kinase (MAP4K4) ligands and it was able to predict the pose within 2 Å root mean square deviation (RMSD) either as the top pose or among the best of five poses in a majority of cases. Specifically for HSP90 protein, a median RMSD of 0.73 and 0.68 Å was obtained for the top and the best of five predictions respectively. For MAP4K4 target, although the median RMSD for our top prediction was only 2.87 Å but the median RMSD of 1.67 Å for the best of five predictions was well within the limit for successful prediction. Furthermore, the performance of our pose prediction method for HSP90 and MAP4K4 ligands was always among the top five groups. Particularly, for MAP4K4 protein our pose prediction method was ranked number one both in terms of mean and median RMSD when the best of five predictions were considered. Overall, our D3R Grand Challenge 2015 results demonstrated that ligand 3D shape similarity with the crystal ligand is sufficient to predict binding poses of new ligands with acceptable accuracy.

  20. Development of a Multi-functional Soft Robot (SNUMAX and Performance in RoboSoft Grand Challenge

    Directory of Open Access Journals (Sweden)

    Jun-Young Lee

    2016-10-01

    Full Text Available This paper introduces SNUMAX, the grand winner of the RoboSoft Grand Challenge. SNUMAX was built to complete all the tasks of the challenge. Completing these tasks required robotic compliant components that could adapt to variable situations and environments and generate enough stiffness to maintain performance. SNUMAX has three key components: transformable origami wheels, a polymer-based variable stiffness manipulator, and an adaptive caging gripper. This paper describes the design of these components and how they worked together to allow the robot to perform the contest’s navigation and manipulation tasks.

  1. DARPA Robotics Grand Challenge Participation and Ski-Type Gait for Rough-Terrain Walking

    Directory of Open Access Journals (Sweden)

    Hongfei Wang

    2015-03-01

    Full Text Available In this paper, we briefly introduce the history of the Defense Advanced Research Projects Agency (DARPA Grand Challenge programs with particular focus on the 2012 Robotics Challenge. As members of team DRC-HUBO, we propose different approaches for the Rough-Terrain task, such as enlarged foot pedals and a transformation into quadruped walking. We also introduce a new gait for humanoid robot locomotion to improve stability performance, called the Ski-Type gait. We analyze the stability performance of this gait and use the stability margin to choose between two candidate step sequences, Crawl-1 and Crawl-2. Next, we perform a force/torque analysis for the redundant closed-chain system in the Ski-Type gait, and determine the joint torques by minimizing the total energy consumption. Based on the stability and force/torque analysis, we design a cane length to support a feasible and stable Crawl-2 gait on the HUBO2 humanoid robot platform. Finally, we compare our experimental results with biped walking to validate the Ski-Type gait. We also present our team performance in the trials of the Robotics Challenge.

  2. Addressing China's grand challenge of achieving food security while ensuring environmental sustainability.

    Science.gov (United States)

    Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C; Bailey, Mark; Gordon, Iain J; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin

    2015-02-01

    China's increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies.

  3. Solving the challenges of extended reach well in Brazil; Vencendo desafios em pocos de grande afastamento

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Vicente Abel S.R.; Araujo, Romero G.S.; N. Filho, Aluisio F. [PETROBRAS, Rio de Janeiro, RJ (Brazil); Veneziani, Luciano S. [Halliburton Servicos Ltda., Macae, RJ (Brazil)

    2004-07-01

    With the objective of minimizing costs and allowing oil to be produced from reservoirs near the coast in shallow waters (i.e. less than 3 meters) which make the use of standard marine units impractical, several Extended Reach Wells were drilled from special land based locations in an area with increased environmental awareness (mangroves and 'Salinas'). This was the reality faced in the 'Serra Field' located on the north coast of the state of Rio Grande do Norte (Brasil) and under the management of the Rio Grande do Norte and Ceara Business Unit of PETROBRAS.The ratio between the actual displacement and vertical depth of these wells is approximately 2.7, with actual displacement a bit greater than 2,600 meters, with the idea of reaching displacements exceeding 3,000 meters in the future. In order to drill these wells, special new technologies were adopted; the drilling rig was upgraded, specific software for the development of the project considering both the reservoir and planning of the well, along with the integration and commitment of the Team to follow, execution and that of the service companies resulted in significant improvements in the Drilling Times. Tools adopted in the design of the well, and in the monitoring of the drilling and completion included Torque and Drag Analysis, Rock Mechanics, Drilling Fluids, Well Trajectory, Anti-Collision, Hydraulics and Wellbore Cleaning. This paper will describe the actions taken, the results, challenges and lessons learned during this Exploration Programme in the Serra Field. (author)

  4. Intersections of downscaling, the ethics of climate services, and regional research grand challenges.

    Science.gov (United States)

    Hewitson, B.; Jack, C. D.; Gutowski, W. J., Jr.

    2014-12-01

    Possibly the leading complication for users of climate information for policy and adaptation is the confusing mix of contrasting data sets that offer widely differing (and often times fundamentally contradictory) indications of the magnitude and direction of past and future regional climate change. In this light, the most pressing scientific-societal challenge is the need to find new ways to understand the sources of conflicting messages from multi-model, multi-method and multi-scale disparities, to develop and implement new analytical methodologies to address this difficulty and so to advance the interpretation and communication of robust climate information to decision makers. Compounding this challenge is the growth of climate services which, in view of the confusing mix of climate change messages, raises serious concerns as to the ethics of communication and dissemination of regional climate change data.The Working Group on Regional Climate (WGRC) of the World Climate Research Program (WCRP) oversees the CORDEX downscaling program which offers a systematic approach to compare the CMIP5 GCMs alongside RCMs and Empirical-statistical (ESD) downscaling within a common experimental design, and which facilitates the evaluation and assessment of the relative information content and sources of error. Using results from the CORDEX RCM and ESD evaluation experiment, and set against the regional messages from the CMIP5 GCMs, we examine the differing messages that arise from each data source. These are then considered in terms of the implications of consequence if each data source were to be independently adopted in a real world use-case scenario. This is then cast in the context of the emerging developments on the distillation dilemma - where the pressing need is for multi-method integration - and how this relates to the WCRP regional research grand challenges.

  5. The MICE Grand Challenge Lightcone Simulation II: Halo and Galaxy catalogues

    CERN Document Server

    Crocce, M; Gaztanaga, E; Fosalba, P; Carretero, J

    2013-01-01

    This is the second in a series of three papers in which we present an end-to-end simulation from the MICE collaboration, the MICE Grand Challenge (MICE-GC) run. The N-body contains about 70 billion dark-matter particles in a (3 \\Gpc)^3 comoving volume spanning 5 orders of magnitude in dynamical range. In this paper we introduce the halo and galaxy catalogues built upon it, both in a wide (5000 sq. deg) and deep (z<1.4) light-cone and in several redshift snapshots. Friend-of-friends halos were resolved down to few 10^{11} Msun/h what allowed us to model galaxies down to faint luminosities (absolute magnitudes M_r<-18.9). We used a new hybrid Halo Occupation Distribution and Abundance Matching technique for galaxy assignment. The catalogue includes the Spectral Energy Distributions of all galaxies from which we can model multi-band photometric galaxy surveys. We describe a variety of applications for halo and galaxy clustering statistics. We discuss how mass resolution effects can bias the large scale 2-p...

  6. On the added value of forensic science and grand innovation challenges for the forensic community.

    Science.gov (United States)

    van Asten, Arian C

    2014-03-01

    In this paper the insights and results are presented of a long term and ongoing improvement effort within the Netherlands Forensic Institute (NFI) to establish a valuable innovation programme. From the overall perspective of the role and use of forensic science in the criminal justice system, the concepts of Forensic Information Value Added (FIVA) and Forensic Information Value Efficiency (FIVE) are introduced. From these concepts the key factors determining the added value of forensic investigations are discussed; Evidential Value, Relevance, Quality, Speed and Cost. By unravelling the added value of forensic science and combining this with the future needs and scientific and technological developments, six forensic grand challenges are introduced: i) Molecular Photo-fitting; ii) chemical imaging, profiling and age estimation of finger marks; iii) Advancing Forensic Medicine; iv) Objective Forensic Evaluation; v) the Digital Forensic Service Centre and vi) Real time In-Situ Chemical Identification. Finally, models for forensic innovation are presented that could lead to major international breakthroughs on all these six themes within a five year time span. This could cause a step change in the added value of forensic science and would make forensic investigative methods even more valuable than they already are today.

  7. Hyperresolution Global Land Surface Modeling: Meeting a Grand Challenge for Monitoring Earth's Terrestrial Water

    Science.gov (United States)

    Wood, Eric F.; Roundy, Joshua K.; Troy, Tara J.; van Beek, L. P. H.; Bierkens, Marc F. P.; 4 Blyth, Eleanor; de Roo, Ad; Doell. Petra; Ek, Mike; Famiglietti, James; Gochis, David; van de Giesen, Nick; Houser, Paul; Jaffe, Peter R.; Kollet, Stefan; Lehner, Bernhard; Lettenmaier, Dennis P.; Peters-Lidard, Christa; Sivpalan, Murugesu; Sheffield, Justin; Wade, Andrew; Whitehead, Paul

    2011-01-01

    Monitoring Earth's terrestrial water conditions is critically important to many hydrological applications such as global food production; assessing water resources sustainability; and flood, drought, and climate change prediction. These needs have motivated the development of pilot monitoring and prediction systems for terrestrial hydrologic and vegetative states, but to date only at the rather coarse spatial resolutions (approx.10-100 km) over continental to global domains. Adequately addressing critical water cycle science questions and applications requires systems that are implemented globally at much higher resolutions, on the order of 1 km, resolutions referred to as hyperresolution in the context of global land surface models. This opinion paper sets forth the needs and benefits for a system that would monitor and predict the Earth's terrestrial water, energy, and biogeochemical cycles. We discuss six major challenges in developing a system: improved representation of surface-subsurface interactions due to fine-scale topography and vegetation; improved representation of land-atmospheric interactions and resulting spatial information on soil moisture and evapotranspiration; inclusion of water quality as part of the biogeochemical cycle; representation of human impacts from water management; utilizing massively parallel computer systems and recent computational advances in solving hyperresolution models that will have up to 10(exp 9) unknowns; and developing the required in situ and remote sensing global data sets. We deem the development of a global hyperresolution model for monitoring the terrestrial water, energy, and biogeochemical cycles a grand challenge to the community, and we call upon the international hydrologic community and the hydrological science support infrastructure to endorse the effort.

  8. Listening to the Quiet Voices: Unlocking the Heart of Engineering Grand Challenges

    Directory of Open Access Journals (Sweden)

    George D Catalano

    2012-11-01

    Full Text Available According to the National Academy of Engineering, the list for the Grand Challenges for Engineering are: (1 Make solar energy economical; (2 Provide energy from fusion; (3 Develop carbon sequestration methods; (4 Manage the nitrogen cycle; (5 Provide access to clean water; (6 Restore and improve urban infrastructure; (7 Advance health informatics; (8 Engineer better medicines; (9 Reverse-engineer the brain; (10 Prevent nuclear terror; (11 Secure cyberspace; (12 Enhance virtual reality; (13 Advance personalized learning; and (14 Engineer the tools of scientific discovery. Surely, it may be difficult to find many who would find any reason to disagree with the identification of any of these topics for both the present and future engineers. Rather than object to what is included, I would like to raise the issue of what has been neglected in this list and far too often in engineering—listening to the quiet voices that speak from within each of us from our heart. I am suggesting the act of listening as one additional entry for this most important list.In my view, one set of skills that our profession does not encourage very well is stopping and listening—stopping and listening to each other, stopping and listening to life around us, or stopping and listening even to ourselves. This is a skill that, given the pace of our modern society, technological advances and our cultural conditioning, must be cultivated for it likely will simply either never develop or quickly wither away. The question at hand then becomes how does one cultivate the ability to stop and to listen? The present work offers one such path though clearly there are countless others.

  9. Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration.

    Science.gov (United States)

    Brunner, Dani; Balcı, Fuat; Ludvig, Elliot A

    2012-02-01

    Drug discovery for brain disorders is undergoing a period of upheaval. Faced with an empty drug pipeline and numerous failures of potential new drugs in clinical trials, many large pharmaceutical companies have been shrinking or even closing down their research divisions that focus on central nervous system (CNS) disorders. In this paper, we argue that many of the difficulties facing CNS drug discovery stem from a lack of robustness in pre-clinical (i.e., non-human animal) testing. There are two main sources for this lack of robustness. First, there is the lack of replicability of many results from the pre-clinical stage, which we argue is driven by a combination of publication bias and inappropriate selection of statistical and experimental designs. Second, there is the frequent failure to translate results in non-human animals to parallel results in humans in the clinic. This limitation can only be overcome by developing new behavioral tests for non-human animals that have predictive, construct, and etiological validity. Here, we present these translational difficulties as a "grand challenge" to researchers from comparative cognition, who are well positioned to provide new methods for testing behavior and cognition in non-human animals. These new experimental protocols will need to be both statistically robust and target behavioral and cognitive processes that allow for better connection with human CNS disorders. Our hope is that this downturn in industrial research may represent an opportunity to develop new protocols that will re-kindle the search for more effective and safer drugs for CNS disorders.

  10. The (mathematical modelling process in biosciences

    Directory of Open Access Journals (Sweden)

    Nestor V. Torres

    2015-12-01

    Full Text Available In this communication we introduce a general framework and discussion on the role of models and the modelling process within the scientific activity in the biosciences realm. The objective is sum up the common procedure during the formalization and analysis of a biological problem under the foundations of Systems Biology, which approach the study of biological systems as a whole.We begin by presenting the definitions of (biological system and model. Particular attention is given to the meaning of mathematical model within the context of the biology. Then, we present the modelization and analysis process of biological systems. Three stages are described in detail: conceptualization of the biological system into a model, mathematical formalization of the previous conceptual model and optimization and system management derived from the analysis of the mathematical model.All along this presentation the main features and shortcomings of the process are developed together with a set of rules that could help in the modelling endeavour of any biological system. Special regard is given to the formative requirements and the interdisciplinary nature of this approach. We conclude with some general considerations on the challenges that the modelling are currently posing to the current biology.

  11. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2008-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  12. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  13. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  14. Environmental Biosciences First Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-09-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  15. Grand Challenges of Advanced Computing for Energy Innovation Report from the Workshop Held July 31-August 2, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Larzelere, Alex R.; Ashby, Steven F.; Christensen, Dana C.; Crawford, Dona L.; Khaleel, Mohammad A.; John, Grosh; Stults, B. Ray; Lee, Steven L.; Hammond, Steven W.; Grover, Benjamin T.; Neely, Rob; Dudney, Lee Ann; Goldstein, Noah C.; Wells, Jack; Peltz, Jim

    2013-03-06

    On July 31-August 2 of 2012, the U.S. Department of Energy (DOE) held a workshop entitled Grand Challenges of Advanced Computing for Energy Innovation. This workshop built on three earlier workshops that clearly identified the potential for the Department and its national laboratories to enable energy innovation. The specific goal of the workshop was to identify the key challenges that the nation must overcome to apply the full benefit of taxpayer-funded advanced computing technologies to U.S. energy innovation in the ways that the country produces, moves, stores, and uses energy. Perhaps more importantly, the workshop also developed a set of recommendations to help the Department overcome those challenges. These recommendations provide an action plan for what the Department can do in the coming years to improve the nation’s energy future.

  16. Environmental Biosciences Program Quarterly Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2009-01-30

    Current research projects have focused Environmental Biosciences Program (EBP) talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene, low-dose ionizing radiation (gamma and neutron) and alpha radiation from plutonium. Trichloroethylene research has been conducted as a joint collaborative effort with the University of Georgia. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the United States Department of Energy (DOE). Laboratory work has been completed on several trichloroethylene risk assessment projects, and these projects have been brought to a close. Plans for restructuring the performance schedule of the remaining trichloroethylene projects have been submitted to the department. A comprehensive manuscript on the scientific basis of trichloroethylene risk assessment is in preparation. Work on the low-dose radiation risk assessment projects is also progressing at a slowed rate as a result of funding uncertainties. It has been necessary to restructure the proponency and performance schedule of these projects, with the project on Low-Dose Radiation: Epidemiology Risk Models transferred to DOE Office of Science proponency under a separate funding instrument. Research on this project will continue under the provisions of the DOE Office of Science funding instrument, with progress reported in accordance with the requirements of that funding instrument. Progress on that project will no longer be reported in quarterly reports for DE-FC09-02CH11109. Following a meeting at the Savannah River Site on May 8, 2008, a plan was submitted for development of an epidemiological cohort study and prospective medical surveillance system for the assessment of disease rates among workers at the Savannah River

  17. Development of an Electronic Role-Play Assessment Initiative in Bioscience for Nursing Students

    Science.gov (United States)

    Craft, Judy; Ainscough, Louise

    2015-01-01

    Devising authentic assessments for subjects with large enrolments is a challenge. This study describes an electronic role-play assessment for approximately 600 first-year nursing students to learn and apply pathophysiology (bioscience) concepts to nursing practice. Students used Microsoft Office PowerPoint[R] to prepare electronic role-plays both…

  18. Scientific Grand Challenges: Challenges in Climate Change Science and the Role of Computing at the Extreme Scale

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.; Johnson, Gary M.; Washington, Warren M.

    2009-07-02

    The U.S. Department of Energy (DOE) Office of Biological and Environmental Research (BER) in partnership with the Office of Advanced Scientific Computing Research (ASCR) held a workshop on the challenges in climate change science and the role of computing at the extreme scale, November 6-7, 2008, in Bethesda, Maryland. At the workshop, participants identified the scientific challenges facing the field of climate science and outlined the research directions of highest priority that should be pursued to meet these challenges. Representatives from the national and international climate change research community as well as representatives from the high-performance computing community attended the workshop. This group represented a broad mix of expertise. Of the 99 participants, 6 were from international institutions. Before the workshop, each of the four panels prepared a white paper, which provided the starting place for the workshop discussions. These four panels of workshop attendees devoted to their efforts the following themes: Model Development and Integrated Assessment; Algorithms and Computational Environment; Decadal Predictability and Prediction; Data, Visualization, and Computing Productivity. The recommendations of the panels are summarized in the body of this report.

  19. Integrating anticipated nutrigenomics bioscience applications with ethical aspects.

    Science.gov (United States)

    Lévesque, Lise; Ozdemir, Vural; Gremmen, Bart; Godard, Béatrice

    2008-03-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surrounding nutrigenomics face the challenges of a rapidly evolving field which bring forward the additional dimension of crossdisciplinary integrative research between social and biomedical sciences. This article outlines the emerging nutrigenomics definitions and concepts and analyzes the existing ethics literature concerning personalized nutrition and presents "points to consider" over ethical issues regarding future nutrigenomics applications. The interest in nutrigenomics coincides with a shift in emphasis in medicine and biosciences toward prevention of future disease susceptibilities rather than treatment of already established disease. Hence, unique ethical issues emerge concerning the extent to which nutrigenomics can alter our relation to food, boundaries between health and disease, and the folklore of medical practice. Nutrigenomics can result in new social values, norms, and responsibilities for both individuals and societies. Nutrigenomics is not only another new application of "-omics" technologies in the context of gene-diet interactions. Nutrigenomics may fundamentally change the way we perceive human illness while shifting the focus and broadening the scope of health interventions from patients to healthy individuals. In resource- and time-limited healthcare settings, this creates unique ethical dilemmas and distributive justice issues. Ethical aspects of nutrigenomics applications should be addressed proactively, as this new science develops and increasingly coalesces with other applications of genomics in medicine and public health.

  20. Object-oriented programming for the biosciences.

    Science.gov (United States)

    Wiechert, W; Joksch, B; Wittig, R; Hartbrich, A; Höner, T; Möllney, M

    1995-10-01

    The development of software systems for the biosciences is always closely connected to experimental practice. Programs must be able to handle the inherent complexity and heterogeneous structure of biological systems in combination with the measuring equipment. Moreover, a high degree of flexibility is required to treat rapidly changing experimental conditions. Object-oriented methodology seems to be well suited for this purpose. It enables an evolutionary approach to software development that still maintains a high degree of modularity. This paper presents experience with object-oriented technology gathered during several years of programming in the fields of bioprocess development and metabolic engineering. It concentrates on the aspects of experimental support, data analysis, interaction and visualization. Several examples are presented and discussed in the general context of the experimental cycle of knowledge acquisition, thus pointing out the benefits and problems of object-oriented technology in the specific application field of the biosciences. Finally, some strategies for future development are described.

  1. Neuroscience meets salivary bioscience: An integrative perspective.

    Science.gov (United States)

    Segal, Sabrina K

    2016-04-01

    Advances in salivary bioscience enable unique opportunities to explore individual differences in biological mechanisms related to learning and memory, psychiatric disorders, and more recently neurodegenerative diseases, neurotrauma/stroke, pain, and sleep. Sampling oral fluid is not only minimally invasive, but specimens can be collected easily and quickly in clinical and field settings. Salivary analytes allow neuroscientists to index endocrine, autonomic, immune, metabolic, and inflammatory processes within close proximity of discrete behavioral, biological, and social events, which is particularly important to advancing our understanding of human neuroscience. This review provides an update on the advances in salivary bioscience for specialty fields within neuroscience, presents novel salivary analytes of interest to neuroscience and the status of their development, and outlines a procedural framework to facilitate integration of these concepts and methods into neuroscience. (PsycINFO Database Record

  2. 77 FR 51983 - Availability of Department of Energy EV Everywhere Grand Challenge Initial Framing Document and...

    Science.gov (United States)

    2012-08-28

    ... Challenge Initial Framing Document and Request for Public Comment AGENCY: Office of Energy Efficiency and... 7, 2012. The EV Everywhere Initial Framing Document (framing document) has been developed as a principal means of facilitating stakeholder engagement in ] the planning process. The framing...

  3. Innovation in a warming world. Research tackling Europe's grand challenge of climate change

    NARCIS (Netherlands)

    Usanov, A.; Gehem, M.

    2012-01-01

    Climate change is arguably the largest environmental challenge facing humankind. Though the impact will be gradual and difficult to predict, we slowly start to understand how this process will affect our planet. The study "Innovation in a Warming World" spells out these effects, specifically for Eur

  4. Bringing Vision-Based Measurements into our Daily Life: A Grand Challenge for Computer Vision Systems

    OpenAIRE

    Scharcanski, Jacob

    2016-01-01

    Bringing computer vision into our daily life has been challenging researchers in industry and in academia over the past decades. However, the continuous development of cameras and computing systems turned computer vision-based measurements into a viable option, allowing new solutions to known problems. In this context, computer vision is a generic tool that can be used to measure and monitor phenomena in wide range of fields. The idea of using vision-based measurements is appealing, since the...

  5. The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation.

    Science.gov (United States)

    Lewis, Jedediah K; Bischof, John C; Braslavsky, Ido; Brockbank, Kelvin G M; Fahy, Gregory M; Fuller, Barry J; Rabin, Yoed; Tocchio, Alessandro; Woods, Erik J; Wowk, Brian G; Acker, Jason P; Giwa, Sebastian

    2016-04-01

    The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence Berkeley National Labs. Experts at the summit outlined the potential public health impact of organ banking, discussed the major remaining scientific challenges that need to be overcome in order to bank organs, and identified key opportunities to accelerate progress toward this goal. Many areas of public health could be revolutionized by the banking of organs and other complex tissues, including transplantation, oncofertility, tissue engineering, trauma medicine and emergency preparedness, basic biomedical research and drug discovery - and even space travel. Key remaining scientific sub-challenges were discussed including ice nucleation and growth, cryoprotectant and osmotic toxicities, chilling injury, thermo-mechanical stress, the need for rapid and uniform rewarming, and ischemia/reperfusion injury. A variety of opportunities to overcome these challenge areas were discussed, i.e. preconditioning for enhanced stress tolerance, nanoparticle rewarming, cyroprotectant screening strategies, and the use of cryoprotectant cocktails including ice binding agents.

  6. Developing Research Capabilities in Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Donald D.

    2008-01-01

    Scientists founded the Life Sciences Research Foundation (LSRF) in 1983 as a non-profit pass through foundation that awards post doctoral fellowships in all areas of the life sciences. LSRF scientists review hundreds of applications each year from PhDs seeking support. For example this year, our 26th, we received 800 applications and our peer review committee will choose about 50 finalists who are eligible for these awards. We have no endowment so we solicit sponsors each year. The fellowships are sponsored by research oriented companies, foundations, philanthropists, the Howard Hughes Medical Institute, and other organizations who believe in the value of awarding fellowships to the best and the brightest young scientists. Our web site has a complete listing of all details about LSRF (http://www.lsrf.org/). In the late 1980s the Division of Bioscience in the Office of Basic Energy Science, a granting agency of the Department of Energy, joined this partnership. Bioscience's mandate was to support non-medical microbiology and plant sciences. LSRF received a series of 5 year grants from DOE to award fellowships to our top applicants in these fields of research. We began to support DOE-Energy Bioscience post doctoral fellows in 1989. From 1989 through 2004 when DOE funding ended our partnership awarded 41 DOE-Energy Bioscience Fellows of the Life Sciences Research Foundation. Each of these was a three year fellowship. DOE-Energy Biosciences was well matched with LSRF. Our extensive peer review screened applicants in all areas of the life sciences. Most LSRF sponsors are interested in supporting fellows who work on diseases. At the time that we began our partnership with DOE we had no sponsors willing to support plant biology and non medical microbiology. For 15 years DOE played a major role in the training of the very best young scientists in these important fields of research simply through its support of LSRF post doctoral fellows. Young scientists interested in

  7. An Overview of Interdisciplinary Research at Notre Dame Addressing "Grand Challenges" in the Midwest and Great Lakes Region

    Science.gov (United States)

    Hamlet, A. F.; Bolster, D.; Tank, J. L.; Hellmann, J.; Christopher, S. F.; Sharma, A.; Chiu, C. M.

    2014-12-01

    The Midwest and Great Lakes region face a number of "Grand Challenges" associated with climate, land use, agriculture, and water resources infrastructure. These include sustainability of agricultural systems and related impacts to food security and the regional economy; sustainability of Great Lakes water levels; changing storm statistics and impacts to stormwater management and flooding; water quality in rivers and downstream receiving water bodies related to non-point source pollution on agricultural lands and combined sewer overflows in urban areas; urban impacts related to aging infrastructure and climate change, and ecosystem management and restoration. In the context of water management, groundwater resources are poorly understood in comparison with surface water resources, and regional-scale simulation models are needed to address questions of sustainability both in terms of supply and water quality. Interdisciplinary research at the University of Notre Dame is attempting to address these research challenges via 1) integrated macro-scale groundwater and surface water modeling to address issues related to sustainable water supply, ecosystem restoration, and agricultural impacts; 2) development of high-resolution regional climate models dynamically coupled to the Great Lakes to address urban impacts, changing storm statistics and to quantify precipitation and evaporation over the Great Lakes; 3) and integrated macro-scale hydrology and water quality modeling to assess the large-scale performance of innovative land management BMPs on agricultural land (such as the two-stage ditch, cover crops, and dynamic drainage control) intended to improve water quality.

  8. How to improve R&D productivity: the pharmaceutical industry's grand challenge.

    Science.gov (United States)

    Paul, Steven M; Mytelka, Daniel S; Dunwiddie, Christopher T; Persinger, Charles C; Munos, Bernard H; Lindborg, Stacy R; Schacht, Aaron L

    2010-03-01

    The pharmaceutical industry is under growing pressure from a range of environmental issues, including major losses of revenue owing to patent expirations, increasingly cost-constrained healthcare systems and more demanding regulatory requirements. In our view, the key to tackling the challenges such issues pose to both the future viability of the pharmaceutical industry and advances in healthcare is to substantially increase the number and quality of innovative, cost-effective new medicines, without incurring unsustainable R&D costs. However, it is widely acknowledged that trends in industry R&D productivity have been moving in the opposite direction for a number of years. Here, we present a detailed analysis based on comprehensive, recent, industry-wide data to identify the relative contributions of each of the steps in the drug discovery and development process to overall R&D productivity. We then propose specific strategies that could have the most substantial impact in improving R&D productivity.

  9. Tipping Points and Balancing Acts: Grand Challenges and Synergistic Opportunities of Integrating Research and Education, Science and Solutions

    Science.gov (United States)

    McCaffrey, M. S.; Stroeve, J. C.

    2011-12-01

    The "Grand Challenges" to address Global Change identified by the International Council for Science (ICSU) and its partners through the Earth System Sustainability Initiative-improving forecasting, enhancing and integrating observation systems, confining and minimizing global environmental change, responding effectively to change, as well as innovating and evaluating these efforts-require an integrative approach that engages and inspires society in general and young people in particular. What are some of the effective strategies-and stumbling blocks-in being able to make Earth System science and related sustainability efforts relevant and practical to non-technical audiences? Recent climate education projects have pioneered new strategies toward linking and infusing research with education, science with solutions. For example, the Climate Literacy and Energy Awareness Network (CLEAN), a National Science Digital Library Pathway funded by NSF, has approached this integral approach by "closing the loop" between climate and energy topics, identifying and annotating high quality online resources relating to the carbon cycle and related topics. The Inspiring Climate Education Excellence (ICEE) project, funded by NASA, offers professional development for teachers that infuses climate science with solutions as an emerging "best practice" while being sensitive to the emotional, psychological and political aspects of avoiding "gloom and doom" on one hand or advocating for particular policy solutions on another. Other examples includes NASA's climate website (http://climate.nasa.gov ), which serves as a robust, engaging portal for climate research and data, especially for educators. The recent PBS series Earth: The Operators' Manual and related book and website are other recent example of how climate science research, education and solutions can be incorporated in a way that is appealing and informative. The Alliance for Climate Education (ACE) has given assemblies in

  10. Scientific Grand Challenges: Forefront Questions in Nuclear Science and the Role of High Performance Computing

    Energy Technology Data Exchange (ETDEWEB)

    Khaleel, Mohammad A.

    2009-10-01

    This report is an account of the deliberations and conclusions of the workshop on "Forefront Questions in Nuclear Science and the Role of High Performance Computing" held January 26-28, 2009, co-sponsored by the U.S. Department of Energy (DOE) Office of Nuclear Physics (ONP) and the DOE Office of Advanced Scientific Computing (ASCR). Representatives from the national and international nuclear physics communities, as well as from the high performance computing community, participated. The purpose of this workshop was to 1) identify forefront scientific challenges in nuclear physics and then determine which-if any-of these could be aided by high performance computing at the extreme scale; 2) establish how and why new high performance computing capabilities could address issues at the frontiers of nuclear science; 3) provide nuclear physicists the opportunity to influence the development of high performance computing; and 4) provide the nuclear physics community with plans for development of future high performance computing capability by DOE ASCR.

  11. Next-Generation Photon Sources for Grand Challenges in Science and Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    report identifies two aspects of energy science in which next-generation ultraviolet and X-ray light sources will have the deepest and broadest impact: (1) The temporal evolution of electrons, spins, atoms, and chemical reactions, down to the femtosecond time scale. (2) Spectroscopic and structural imaging of nano objects (or nanoscale regions of inhomogeneous materials) with nanometer spatial resolution and ultimate spectral resolution. The dual advances of temporal and spatial resolution promised by fourth-generation light sources ideally match the challenges of control science. Femtosecond time resolution has opened completely new territory where atomic motion can be followed in real time and electronic excitations and decay processes can be followed over time. Coherent imaging with short-wavelength radiation will make it possible to access the nanometer length scale, where intrinsic quantum behavior becomes dominant. Performing spectroscopy on individual nanometer-scale objects rather than on conglomerates will eliminate the blurring of the energy levels induced by particle size and shape distributions and reveal the energetics of single functional units. Energy resolution limited only by the uncertainty relation is enabled by these advances. Current storage-ring-based light sources and their incremental enhancements cannot meet the need for femtosecond time resolution, nanometer spatial resolution, intrinsic energy resolution, full coherence over energy ranges up to hard X-rays, and peak brilliance required to enable the new science outlined in this report. In fact, the new, unexplored territory is so expansive that no single currently imagined light source technology can fulfill the whole potential. Both technological and economic challenges require resolution as we move forward. For example, femtosecond time resolution and high peak brilliance are required for following chemical reactions in real time, but lower peak brilliance and high repetition rate are needed

  12. Communicating Geosciences with Policy-makers: a Grand Challenge for Academia

    Science.gov (United States)

    Harrison, W. J.; Walls, M. R.; Boland, M. A.

    2015-12-01

    Geoscientists interested in the broader societal impacts of their research can make a meaningful contribution to policy making in our changing world. Nevertheless, policy and public decision making are the least frequently cited Broader Impacts in proposals and funded projects within NSF's Geosciences Directorate. Academic institutions can play a lead role by introducing this societal dimension of our profession to beginning students, and by enabling interdisciplinary research and promoting communication pathways for experienced career geoscientists. Within the academic environment, the public interface of the geosciences can be presented through curriculum content and creative programs. These include undergraduate minors in economics or public policy designed for scientists and engineers, and internships with policy makers. Federal research institutions and other organizations provide valuable policy-relevant experiences for students. Academic institutions have the key freedom of mission to tackle interdisciplinary research challenges at the interface of geoscience and policy. They develop long-standing relationships with research partners, including national laboratories and state geological surveys, whose work may support policy development and analysis at local, state, regional, and national levels. CSM's Payne Institute for Earth Resources awards mini-grants for teams of researchers to develop collaborative research efforts between engineering/science and policy researchers. Current work in the areas of nuclear generation and the costs of climate policy and on policy alternatives for capturing fugitive methane emissions are examples of work at the interface between the geosciences and public policy. With academic engagement, geoscientists can steward their intellectual output when non-scientists translate geoscience information and concepts into action through public policies.

  13. AI in medical education--another grand challenge for medical informatics.

    Science.gov (United States)

    Lillehaug, S I; Lajoie, S P

    1998-03-01

    The potential benefits of artificial intelligence in medicine (AIM) were never realized as anticipated. This paper addresses ways in which such potential can be achieved. Recent discussions of this topic have proposed a stronger integration between AIM applications and health information systems, and emphasize computer guidelines to support the new health care paradigms of evidence-based medicine and cost-effectiveness. These proposals, however, promote the initial definition of AIM applications as being AI systems that can perform or aid in diagnoses. We challenge this traditional philosophy of AIM and propose a new approach aiming at empowering health care workers to become independent self-sufficient problem solvers and decision makers. Our philosophy is based on findings from a review of empirical research that examines the relationship between the health care personnel's level of knowledge and skills, their job satisfaction, and the quality of the health care they provide. This review supports addressing the quality of health care by empowering health care workers to reach their full potential. As an aid in this empowerment process we argue for reviving a long forgotten AIM research area, namely, AI based applications for medical education and training. There is a growing body of research in artificial intelligence in education that demonstrates that the use of artificial intelligence can enhance learning in numerous domains. By examining the strengths of these educational applications and the results from previous AIM research we derive a framework for empowering medical personnel and consequently raising the quality of health care through the use of advanced AI based technology.

  14. Next-Generation Photon Sources for Grand Challenges in Science and Energy

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    report identifies two aspects of energy science in which next-generation ultraviolet and X-ray light sources will have the deepest and broadest impact: (1) The temporal evolution of electrons, spins, atoms, and chemical reactions, down to the femtosecond time scale. (2) Spectroscopic and structural imaging of nano objects (or nanoscale regions of inhomogeneous materials) with nanometer spatial resolution and ultimate spectral resolution. The dual advances of temporal and spatial resolution promised by fourth-generation light sources ideally match the challenges of control science. Femtosecond time resolution has opened completely new territory where atomic motion can be followed in real time and electronic excitations and decay processes can be followed over time. Coherent imaging with short-wavelength radiation will make it possible to access the nanometer length scale, where intrinsic quantum behavior becomes dominant. Performing spectroscopy on individual nanometer-scale objects rather than on conglomerates will eliminate the blurring of the energy levels induced by particle size and shape distributions and reveal the energetics of single functional units. Energy resolution limited only by the uncertainty relation is enabled by these advances. Current storage-ring-based light sources and their incremental enhancements cannot meet the need for femtosecond time resolution, nanometer spatial resolution, intrinsic energy resolution, full coherence over energy ranges up to hard X-rays, and peak brilliance required to enable the new science outlined in this report. In fact, the new, unexplored territory is so expansive that no single currently imagined light source technology can fulfill the whole potential. Both technological and economic challenges require resolution as we move forward. For example, femtosecond time resolution and high peak brilliance are required for following chemical reactions in real time, but lower peak brilliance and high repetition rate are needed

  15. Promoting active learning using audience response system in large bioscience classes.

    Science.gov (United States)

    Efstathiou, Nikolaos; Bailey, Cara

    2012-01-01

    This paper considers the challenges of bioscience teaching and learning in pre-registration nurse education. Effective learning requires active student participation which is problematic when teaching large groups of students. New technologies, such as the audience response system (ARS), have been introduced to increase student participation and support them in the understanding of complex bioscience concepts. Within one university department, an evaluation was undertaken to identify the perceptions of pre-registration nurse students on the use of ARS in the teaching and learning of bioscience. Our findings concur with others that ARS increases student participation and aids in identifying misconceptions and in correcting them. Students found ARS very useful and wanted ARS to be used in additional modules too. Although ARS did not seem to motivate students to study adequately before attending the relevant sessions, it increased discussion among students and awareness of their level of knowledge compared to their peers. Further research is required to identify the effectiveness of ARS in the teaching and learning of bioscience and its impact on the performance of the students in their final assessments.

  16. Introducing bioinformatics, the biosciences' genomic revolution

    CERN Document Server

    Zanella, Paolo

    1999-01-01

    The general audience for these lectures is mainly physicists, computer scientists, engineers or the general public wanting to know more about what’s going on in the biosciences. What’s bioinformatics and why is all this fuss being made about it ? What’s this revolution triggered by the human genome project ? Are there any results yet ? What are the problems ? What new avenues of research have been opened up ? What about the technology ? These new developments will be compared with what happened at CERN earlier in its evolution, and it is hoped that the similiraties and contrasts will stimulate new curiosity and provoke new thoughts.

  17. Interaction with specific HSP90 residues as a scoring function: validation in the D3R Grand Challenge 2015

    Science.gov (United States)

    Santos-Martins, Diogo

    2016-09-01

    Here is reported the development of a novel scoring function that performs remarkably well at identifying the native binding pose of a subset of HSP90 inhibitors containing aminopyrimidine or resorcinol based scaffolds. This scoring function is called PocketScore, and consists of the interaction energy between a ligand and three residues in the binding pocket: Asp93, Thr184 and a water molecule. We integrated PocketScore into a molecular docking workflow, and used it to participate in the Drug Design Data Resource (D3R) Grand Challenge 2015 (GC2015). PocketScore was able to rank 180 molecules of the GC2015 according to their binding affinity with satisfactory performance. These results indicate that the specific residues considered by PocketScore are determinant to properly model the interaction between HSP90 and its subset of inhibitors containing aminopyrimidine or resorcinol based scaffolds. Moreover, the development of PocketScore aimed at improving docking power while neglecting the prediction of binding affinities, suggesting that accurate identification of native binding poses is a determinant factor for the performance of virtual screens.

  18. DockBench as docking selector tool: the lesson learned from D3R Grand Challenge 2015

    Science.gov (United States)

    Salmaso, Veronica; Sturlese, Mattia; Cuzzolin, Alberto; Moro, Stefano

    2016-09-01

    Structure-based drug design (SBDD) has matured within the last two decades as a valuable tool for the optimization of low molecular weight lead compounds to highly potent drugs. The key step in SBDD requires knowledge of the three-dimensional structure of the target-ligand complex, which is usually determined by X-ray crystallography. In the absence of structural information for the complex, SBDD relies on the generation of plausible molecular docking models. However, molecular docking protocols suffer from inaccuracies in the description of the interaction energies between the ligand and the target molecule, and often fail in the prediction of the correct binding mode. In this context, the appropriate selection of the most accurate docking protocol is absolutely relevant for the final molecular docking result, even if addressing this point is absolutely not a trivial task. D3R Grand Challenge 2015 has represented a precious opportunity to test the performance of DockBench, an integrate informatics platform to automatically compare RMDS-based molecular docking performances of different docking/scoring methods. The overall performance resulted in the blind prediction are encouraging in particular for the pose prediction task, in which several complex were predicted with a sufficient accuracy for medicinal chemistry purposes.

  19. Optimal strategies for virtual screening of induced-fit and flexible target in the 2015 D3R Grand Challenge

    Science.gov (United States)

    Ye, Zhaofeng; Baumgartner, Matthew P.; Wingert, Bentley M.; Camacho, Carlos J.

    2016-09-01

    Induced fit or protein flexibility can make a given structure less useful for docking and/or scoring. The 2015 Drug Design Data Resource (D3R) Grand Challenge provided a unique opportunity to prospectively test optimal strategies for virtual screening in these type of targets: heat shock protein 90 (HSP90), a protein with multiple ligand-induced binding modes; and mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), a kinase with a large flexible pocket. Using previously known co-crystal structures, we tested predictions from methods that keep the receptor structure fixed and used (a) multiple receptor/ligand co-crystals as binding templates for minimization or docking ("close"), (b) methods that align or dock to a single receptor ("cross"), and (c) a hybrid approach that chose from multiple bound ligands as initial templates for minimization to a single receptor ("min-cross"). Pose prediction using our "close" models resulted in average ligand RMSDs of 0.32 and 1.6 Å for HSP90 and MAP4K4, respectively, the most accurate models of the community-wide challenge. On the other hand, affinity ranking using our "cross" methods performed well overall despite the fact that a fixed receptor cannot model ligand-induced structural changes,. In addition, "close" methods that leverage the co-crystals of the different binding modes of HSP90 also predicted the best affinity ranking. Our studies suggest that analysis of changes on the receptor structure upon ligand binding can help select an optimal virtual screening strategy.

  20. Combining Multidisciplinary Science, Quantitative Reasoning and Social Context to Teach Global Sustainability and Prepare Students for 21st Grand Challenges

    Science.gov (United States)

    Myers, J. D.

    2011-12-01

    The Earth's seven billion humans are consuming a growing proportion of the world's ecosystem products and services. Human activity has also wrought changes that rival the scale of many natural geologic processes, e.g. erosion, transport and deposition, leading to recognition of a new geological epoch, the Anthropocene. Because of these impacts, several natural systems have been pushed beyond the planetary boundaries that made the Holocene favorable for the expansion of humanity. Given these human-induced stresses on natural systems, global citizens will face an increasing number of grand challenges. Unfortunately, traditional discipline-based introductory science courses do little to prepare students for these complex, scientifically-based and technologically-centered challenges. With NSF funding, an introductory, integrated science course stressing quantitative reasoning and social context has been created at UW. The course (GEOL1600: Global Sustainability: Managing the Earth's Resources) is a lower division course designed around the energy-water-climate (EWC) nexus and integrating biology, chemistry, Earth science and physics. It melds lectures, lecture activities, reading questionnaires and labs to create a learning environment that examines the EWT nexus from a global through regional context. The focus on the EWC nexus, while important socially and intended to motivate students, also provides a coherent framework for identifying which disciplinary scientific principles and concepts to include in the course: photosynthesis and deep time (fossil fuels), biogeochemical cycles (climate), chemical reactions (combustion), electromagnetic radiation (solar power), nuclear physics (nuclear power), phase changes and diagrams (water and climate), etc. Lecture activities are used to give students the practice they need to make quantitative skills routine and automatic. Laboratory exercises on energy (coal, petroleum, nuclear power), water (in Bangladesh), energy

  1. Grand Challenges for Seismology

    Science.gov (United States)

    Forsyth, Donald W.; Lay, Thorne; Aster, Richard C.; Romanowicz, Barbara

    2009-10-01

    Seismology is the study of the propagation of elastic waves, the sources that generate them, and the structures through which they propagate. It also is a fundamental, high-resolution tool for exploring the interior of the Earth from crust to core, as well as other bodies in the solar system. A remarkable diversity of multidisciplinary societal applications of seismology has emerged, including hydrocarbon and resource exploration, earthquake detection and hazard assessment, nuclear test monitoring and treaty verification, volcano and tsunami warning systems, and aquifer characterization. New directions in seismology are evolving that are relevant to climate and environmental change, such as resolving fine-scale seismic stratigraphy, monitoring carbon sequestration, detecting sudden movements of glaciers and ice sheets, mapping the internal fine structure of the ocean, and reconstructing the twentieth-century history of global storm activity from ocean-generated seismic noise.

  2. Conference scene: Select Biosciences Epigenetics Europe 2010.

    Science.gov (United States)

    Razvi, Enal S

    2011-02-01

    The field of epigenetics is now on a geometric rise, driven in a large part by the realization that modifiers of chromatin are key regulators of biological processes in vivo. The three major classes of epigenetic effectors are DNA methylation, histone post-translational modifications (such as acetylation, methylation or phosphorylation) and small noncoding RNAs (most notably microRNAs). In this article, I report from Select Biosciences Epigenetics Europe 2010 industry conference held on 14-15 September 2010 at The Burlington Hotel, Dublin, Ireland. This industry conference was extremely well attended with a global pool of delegates representing the academic research community, biotechnology companies and pharmaceutical companies, as well as the technology/tool developers. This conference represented the current state of the epigenetics community with cancer/oncology as a key driver. In fact, it has been estimated that approximately 45% of epigenetic researchers today identify cancer/oncology as their main area of focus vis-à-vis their epigenetic research efforts.

  3. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  4. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  5. Environmental Biosciences Quarterly Report, September - December, 2005

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-01-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  6. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2003-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  7. Second Quarter Report Environmental Biosciences Program

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2002-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  8. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.d.

    2003-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  9. Environmental Biosciences Program Report for Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-10-15

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  10. Environmental Biosciences Program Third Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), asbestos and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  11. The Bioscience Nuclear Microscopy Program at LLNL

    Energy Technology Data Exchange (ETDEWEB)

    Bench, G.; Freeman, S.; Roberts, M.; Sideras-Haddad, E.

    1996-12-31

    Since initiation in mid 1994, a bioscience nuclear microscopy program at Livermore has enabled collaboration with bio-scientists on a variety of projects requiring quantitative elemental microanalysis. For microprobe analysis a combination of PIXE and STIM are typically used; respectively generating element distribution maps with micron scale spatial resolution, and projected densities and histological information with sub-micron spatial resolution. Current studies demonstrate the applicability of nuclear microscopy (particularly when combined with other analysis techniques) in environmental tracing, toxicology, carcinogenesis, and structural biology. The program currently uses {approximately}10 percent of the available time on a 10 MV tandem accelerator that is also applied to a variety of Accelerator Mass Spectrometry and other microprobe programs. The completion of a dedicated nuclear microprobe system, using a 5 SDH NEC 1.7 MV tandem accelerator and employing several energy dispersive x-ray detectors to improve x-ray counting rates, promises increased accelerator access, greater sample throughput and continued expansion of the program.

  12. Environmental Biosciences Program Report for Year Three

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  13. Foods: Where Innovation, Agriculture, Molecular Biosciences and Human Nutrition Meet

    Directory of Open Access Journals (Sweden)

    Charles Brennan

    2012-11-01

    Full Text Available There is one commodity the world over that unites mankind—food. In 2011 the United Nations claimed that the world’s population had reached the seven billion mark, a number which is set to increase dramatically in the decades to come. Food security, supply and sustainability are of paramount concern to the future economic and social progress of humanity. It is the responsibility of the food industry, together with food scientists and technologists, to shoulder the burden of ensuring an adequate supply of nutritious, safe and sensorially acceptable foods for a range of demanding consumers. In responding to this challenge, we need to understand the link between agriculture, engineering, food processing, molecular biosciences, human nutrition, commercialisation and innovation. Access to information concerning the composition and quality of foods has never been so easy for consumers and technologists alike. A plethora of research publications are made available each month to scientists and associated interested parties. The outcomes of these research manuscripts are often distilled and disseminated into messages available to everyone through bulletin boards, forums and the popular press. Newspapers and new agencies constantly report on the latest pharma-medical finding, or news regarding food safety and security concerns. We live in an age where information is so readily available to everyone that the task of finding credible and reputable data can be difficult at times. Providing sound evidenced based research is where a peer-reviewed journal can provide clarity. [...

  14. Environmental Biosciences Program Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this

  15. Environmental Biosciences Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2007-10-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. Work on the trichloroethylene research projects has been slowed as a result of funding uncertainties. The impact of these funding uncertainties has been discussed with the DOE. Plans for restructuring the performance schedule of the trichloroethylene projects have been submitted to the department. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk based decision-making. Questions, comments or requests for further information concerning the activities under this

  16. Environmental Biosciences Program Fourth Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-06-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation s need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyles (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  17. Environmental Biosciences Program Second Quarter Report

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2004-12-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making. Questions, comments or requests for further information concerning the activities under this cooperative agreement can be forwarded to Dr. Lawrence C. Mohr in the EBP office of the Medical University of South Carolina at (843) 792-1532.

  18. Teaching Critical Appraisal to Sport & Exercise Sciences and Biosciences Students

    Science.gov (United States)

    Phillips, Anna C.

    2009-01-01

    Seminars were implemented to develop undergraduates' critical appraisal skills and their effectiveness was evaluated. Participants were 140 undergraduate students consisting of 103 students from Sport and Exercise Sciences and 37 from Biosciences. Four seminars were employed to develop and reinforce critical thinking and provide an opportunity for…

  19. Integrating anticipated nutrigenomics bioscience applications with ethical aspects

    NARCIS (Netherlands)

    Levesque, L.; Ozdemir, V.; Gremmen, B.; Godard, B.

    2008-01-01

    Nutrigenomics is a subspecialty of nutrition science which aims to understand how gene-diet interactions influence individuals' response to food, disease susceptibility, and population health. Yet ethical enquiry into this field is being outpaced by nutrigenomics bioscience. The ethical issues surro

  20. Evaluation and Comparison of Anatomical Landmark Detection Methods for Cephalometric X-Ray Images: A Grand Challenge.

    Science.gov (United States)

    Wang, Ching-Wei; Huang, Cheng-Ta; Hsieh, Meng-Che; Li, Chung-Hsing; Chang, Sheng-Wei; Li, Wei-Cheng; Vandaele, Rémy; Marée, Raphaël; Jodogne, Sébastien; Geurts, Pierre; Chen, Cheng; Zheng, Guoyan; Chu, Chengwen; Mirzaalian, Hengameh; Hamarneh, Ghassan; Vrtovec, Tomaz; Ibragimov, Bulat

    2015-09-01

    Cephalometric analysis is an essential clinical and research tool in orthodontics for the orthodontic analysis and treatment planning. This paper presents the evaluation of the methods submitted to the Automatic Cephalometric X-Ray Landmark Detection Challenge, held at the IEEE International Symposium on Biomedical Imaging 2014 with an on-site competition. The challenge was set to explore and compare automatic landmark detection methods in application to cephalometric X-ray images. Methods were evaluated on a common database including cephalograms of 300 patients aged six to 60 years, collected from the Dental Department, Tri-Service General Hospital, Taiwan, and manually marked anatomical landmarks as the ground truth data, generated by two experienced medical doctors. Quantitative evaluation was performed to compare the results of a representative selection of current methods submitted to the challenge. Experimental results show that three methods are able to achieve detection rates greater than 80% using the 4 mm precision range, but only one method achieves a detection rate greater than 70% using the 2 mm precision range, which is the acceptable precision range in clinical practice. The study provides insights into the performance of different landmark detection approaches under real-world conditions and highlights achievements and limitations of current image analysis techniques.

  1. Key Concepts for and Assessment of an Undergraduate Class that Engages Engineering Students in Climate Change Grand Challenge

    Science.gov (United States)

    Powers, S. E.; DeWaters, J.; Dhaniyala, S.

    2015-12-01

    Engineers must take a leading role in addressing the challenges of mitigating climate change and adapting to the inevitable changes that our world is facing. Yet climate change classes targeting engineering students are scarce. Technical education must focus on the problem formulation and solutions that consider multiple, complex interactions between engineered systems and the Earth's climate system and recognize that transformation raises societal challenges, including trade-offs among benefits, costs, and risks. Moreover, improving engineering students' climate science literacy will require strategies that also inspire students' motivation to work toward their solution. A climate science course for engineers has been taught 5 semesters as part of a NASA Innovations in Climate Education program grant (NNXlOAB57A). The basic premise of this project was that effective instruction must incorporate scientifically-based knowledge and observations and foster critical thinking, problem solving, and decision-making skills. Lecture, in-class cooperative and computer-based learning and a semester project provide the basis for engaging students in evaluating effective mitigation and adaptation solutions. Policy and social issues are integrated throughout many of the units. The objective of this presentation is to highlight the content and pedagogical approach used in this class that helped to contribute to significant gains in engineering students' climate literacy and critical thinking competencies. A total of 89 students fully participated in a pre/post climate literacy questionnaire. As a whole, students demonstrated significant gains in climate-related content knowledge (pcritical thinking rubric showed that the students did an excellent job of formulating problem statements and solutions in a manner that incorporated a multidimensional systems perspective. These skills are sometimes foreign to technically focused, number crunching engineering students, but are critical

  2. Bioscience methodologies in physical chemistry an engineering and molecular approach

    CERN Document Server

    D'Amore, Alberto

    2013-01-01

    The field of bioscience methodologies in physical chemistry stands at the intersection of the power and generality of classical and quantum physics with the minute molecular complexity of chemistry and biology. This book provides an application of physical principles in explaining and rationalizing chemical and biological phenomena. It does not stick to the classical topics that are conventionally considered as part of physical chemistry; instead it presents principles deciphered from a modern point of view, which is the strength of this book.

  3. Fluorescence lifetime imaging in biosciences: technologies and applications

    Institute of Scientific and Technical Information of China (English)

    Raluca NIESNER; Karl-Heinz GERICKE

    2008-01-01

    The biosciences require the development of methods that allow a non-invasive and rapid investigation of biological systems. In this aspect, high-end imaging tech-niques allow intravital microscopy in real-time, providing information on a molecular basis. Far-field fluorescence imaging techniques are some of the most adequate methods for such investigations. However, there are great differences between the common fluorescence imaging techniques, i.e., wide-field, confocal one-photon and two-photon microscopy, as far as their applicability in diverse bioscientific research areas is concerned. In the first part of this work, we briefly compare these techniques. Standard methods used in the biosciences, i.e., steady-state techniques based on the analy-sis of the total fluorescence signal originating from the sam-ple, can successfully be employed in the study of cell, tissue and organ morphology as well as in monitoring the macro-scopic tissue function. However, they are mostly inadequate for the quantitative investigation of the cellular function at the molecular level. The intrinsic disadvantages of steady-state techniques are countered by using time-resolved tech-niques. Among these fluorescence lifetime imaging (FLIM) is currently the most common. Different FLIM principles as well as applications of particular relevance for the biosci-ences, especially for fast intravital studies are discussed in this work.

  4. Meeting the Grand Challenge of Protecting Astronauts Health: Electrostatic Active Space Radiation Shielding for Deep Space Missions

    Science.gov (United States)

    Tripathi, Ram K.

    2016-01-01

    membrane structure (EIMS) in both charged and uncharged configurations. The amount of charge shielding behind and around the EIMS was studied for different combinations of membrane structure voltages and electron energies. Both passive and active shielding were observed, with active shielding capable of deflecting nearly all incoming electrons. The pattern of charge distribution around the structure was studied as well as the stability of the structures in the charge flow. The charge deflection experiments illustrate that the EIMS remain inflated during charge deflection, but will experience small amplitude oscillations. Investigations were performed to determine a potential cause of the vibrations. It is postulated these vibrations are due to the charge flux causing local membrane charge distribution changes. As the membrane structure inflation pressure is changed, the shape responds, and causes the observed sustained vibration. Having identified this phenomenon is important when considering electrostatically inflated membrane structures (EIMS) in a space environment. Additionally, this project included a study of membrane material impacts, specifically the impact of membrane thickness. Extremely thin materials presented new challenges with vacuum preparation techniques and rapid charging. The thinner and lighter membrane materials were successfully inflated using electrostatic forces in a vacuum chamber. However, care must be taken when varying the potentials of such lighter structures as the currents can cause local heating and melting of the very thin membranes. Lastly, a preliminary analysis is performed to study rough order of magnitude power requirements for using EIMS for radiation shielding. The EIMS power requirement becomes increasingly more challenging as the spacecraft voltage is increased. As a result, the emphasis is on the deflection of charges away from the spacecraft rather than totally stopping them. This significantly alleviates the initial power

  5. The Numerical Tokamak Project (NTP) simulation of turbulent transport in the core plasma: A grand challenge in plasma physics

    Energy Technology Data Exchange (ETDEWEB)

    1993-12-01

    The long-range goal of the Numerical Tokamak Project (NTP) is the reliable prediction of tokamak performance using physics-based numerical tools describing tokamak physics. The NTP is accomplishing the development of the most advanced particle and extended fluid model`s on massively parallel processing (MPP) environments as part of a multi-institutional, multi-disciplinary numerical study of tokamak core fluctuations. The NTP is a continuing focus of the Office of Fusion Energy`s theory and computation program. Near-term HPCC work concentrates on developing a predictive numerical description of the core plasma transport in tokamaks driven by low-frequency collective fluctuations. This work addresses one of the greatest intellectual challenges to our understanding of the physics of tokamak performance and needs the most advanced computational resources to progress. We are conducting detailed comparisons of kinetic and fluid numerical models of tokamak turbulence. These comparisons are stimulating the improvement of each and the development of hybrid models which embody aspects of both. The combination of emerging massively parallel processing hardware and algorithmic improvements will result in an estimated 10**2--10**6 performance increase. Development of information processing and visualization tools is accelerating our comparison of computational models to one another, to experimental data, and to analytical theory, providing a bootstrap effect in our understanding of the target physics. The measure of success is the degree to which the experimentally observed scaling of fluctuation-driven transport may be predicted numerically. The NTP is advancing the HPCC Initiative through its state-of-the-art computational work. We are pushing the capability of high performance computing through our efforts which are strongly leveraged by OFE support.

  6. In what ways do the experiences of students in PhD programs in the molecular biosciences foster knowledge transfer?

    Science.gov (United States)

    Prevost, Amy C.

    Doctoral training in the molecular biosciences often fails to prepare students for academic and alternate careers. Several studies of doctoral training have reported a need to improve doctoral education; outlining specific criticisms related to the need to broaden the scope of the doctoral degree in order to prepare students for careers. The development of doctoral students' knowledge transfer skills is the key to making this transition. The theory advanced in this study extends the literature on doctoral education related to student experiences that foster the development of knowledge transfer skills. These insights will be a resource for academic leaders as they develop new programs and the re-develop existing ones; to students and graduates as they become leaders in their field; and to mentors, who have a large role in the development of doctoral students. Research conducted for this dissertation led to the development of theory about elements of the doctoral experience that foster the development of knowledge transfer skills in the molecular biosciences. In exploring ways the experiences of students in PhD programs in the molecular biosciences foster knowledge transfer, I was able to develop a framework for understanding these experiences in the context of doctoral programs. Students' experiences are affected by different elements of doctoral education. As they develop identities as researchers and scientists, and transition from novices to experts, students' experiences are shaped by their mentors, peers, programs and departments. Subjects spoke about their experiences in interviews. This study exposed a need to balance support and challenge for doctoral students to allow them to develop the capacity to perform scientific research and act as leaders. The development of knowledge transfer skills within this context is important preparation for students in the molecular biosciences. Doctoral students in this area need to apply their expertise in increasingly

  7. Predicting binding poses and affinities for protein - ligand complexes in the 2015 D3R Grand Challenge using a physical model with a statistical parameter estimation

    Science.gov (United States)

    Grudinin, Sergei; Kadukova, Maria; Eisenbarth, Andreas; Marillet, Simon; Cazals, Frédéric

    2016-09-01

    The 2015 D3R Grand Challenge provided an opportunity to test our new model for the binding free energy of small molecules, as well as to assess our protocol to predict binding poses for protein-ligand complexes. Our pose predictions were ranked 3-9 for the HSP90 dataset, depending on the assessment metric. For the MAP4K dataset the ranks are very dispersed and equal to 2-35, depending on the assessment metric, which does not provide any insight into the accuracy of the method. The main success of our pose prediction protocol was the re-scoring stage using the recently developed Convex-PL potential. We make a thorough analysis of our docking predictions made with AutoDock Vina and discuss the effect of the choice of rigid receptor templates, the number of flexible residues in the binding pocket, the binding pocket size, and the benefits of re-scoring. However, the main challenge was to predict experimentally determined binding affinities for two blind test sets. Our affinity prediction model consisted of two terms, a pairwise-additive enthalpy, and a non pairwise-additive entropy. We trained the free parameters of the model with a regularized regression using affinity and structural data from the PDBBind database. Our model performed very well on the training set, however, failed on the two test sets. We explain the drawback and pitfalls of our model, in particular in terms of relative coverage of the test set by the training set and missed dynamical properties from crystal structures, and discuss different routes to improve it.

  8. On the outside looking in: redefining the role of analytical chemistry in the biosciences.

    Science.gov (United States)

    Hare, Dominic J; New, Elizabeth J

    2016-07-12

    Biomedical research has moved on from the study of the structure of organs, cells and organelles. Today, the key questions that must be addressed to understand the body in health and disease are related to fundamental biochemistry: the distribution and speciation of chemicals, the regulation of chemical reactions, and the control of chemical environments. To see advances in this field, it is essential for analytical chemists to actively engage in this process, from beginning to end. In this Feature Article, we review the progress that has been made towards gaining an understanding of the chemistry of the body, while commenting on the intrinsic disconnect between new innovations in the field of analytical chemistry and practical application within the biosciences. We identify the challenges that prevent chemists from making a greater impact in this field, and highlight key steps for moving forward.

  9. Assessment of Collaboration and Interoperability in an Information Management System to Support Bioscience Research

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L.

    2009-01-01

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C4I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the “must have” attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation. PMID:20351900

  10. Assessment of collaboration and interoperability in an information management system to support bioscience research.

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L

    2009-11-14

    Biomedical researchers often have to work on massive, detailed, and heterogeneous datasets that raise new challenges of information management. This study reports an investigation into the nature of the problems faced by the researchers in two bioscience test laboratories when dealing with their data management applications. Data were collected using ethnographic observations, questionnaires, and semi-structured interviews. The major problems identified in working with these systems were related to data organization, publications, and collaboration. The interoperability standards were analyzed using a C(4)I framework at the level of connection, communication, consolidation, and collaboration. Such an analysis was found to be useful in judging the capabilities of data management systems at different levels of technological competency. While collaboration and system interoperability are the "must have" attributes of these biomedical scientific laboratory information management applications, usability and human interoperability are the other design concerns that must also be addressed for easy use and implementation.

  11. Grandes remolques

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1961-07-01

    Full Text Available El empleo creciente del material pesado auxiliar en la construcción de obras de ingeniería civil ha motivado la fabricación de grandes plataformas, capaces de transportar toda clase de maquinaria auxiliar. En general, este tipo de maquinaria requiere medios de transporte, pues su circulación por carreteras es lenta, obstructiva y cara, siempre que se trate de grandes distancias, caso presente en la mayoría de ocasiones en que se exige un traslado de esta maquinaria de una a otra obra.

  12. Big Data and Grand Challenges

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2016-01-01

    The paper discusses the future of the Humanities and the role of Digital Humanities. Taking the point of departure in Rens Bods “A new History of the humanities” (2013) it is argued that the current crisis within the Humanities and Digital Humanities is not as much about different notions of cult...

  13. Big Data and Grand Challenges

    DEFF Research Database (Denmark)

    Finnemann, Niels Ole

    2016-01-01

    Presentation at workshop on ‘Digital Humanities – Directions and Horizons’, June 21, 2016. Center for Communication and Computing, University of Copenhagen. Denmark (KUA Building 27, Room 27.O.17)...

  14. Full text and figure display improves bioscience literature search.

    Directory of Open Access Journals (Sweden)

    Anna Divoli

    Full Text Available When reading bioscience journal articles, many researchers focus attention on the figures and their captions. This observation led to the development of the BioText literature search engine, a freely available Web-based application that allows biologists to search over the contents of Open Access Journals, and see figures from the articles displayed directly in the search results. This article presents a qualitative assessment of this system in the form of a usability study with 20 biologist participants using and commenting on the system. 19 out of 20 participants expressed a desire to use a bioscience literature search engine that displays articles' figures alongside the full text search results. 15 out of 20 participants said they would use a caption search and figure display interface either frequently or sometimes, while 4 said rarely and 1 said undecided. 10 out of 20 participants said they would use a tool for searching the text of tables and their captions either frequently or sometimes, while 7 said they would use it rarely if at all, 2 said they would never use it, and 1 was undecided. This study found evidence, supporting results of an earlier study, that bioscience literature search systems such as PubMed should show figures from articles alongside search results. It also found evidence that full text and captions should be searched along with the article title, metadata, and abstract. Finally, for a subset of users and information needs, allowing for explicit search within captions for figures and tables is a useful function, but it is not entirely clear how to cleanly integrate this within a more general literature search interface. Such a facility supports Open Access publishing efforts, as it requires access to full text of documents and the lifting of restrictions in order to show figures in the search interface.

  15. Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015 with docking, MM/GBSA, QM/MM, and free-energy simulations.

    Science.gov (United States)

    Misini Ignjatović, Majda; Caldararu, Octav; Dong, Geng; Muñoz-Gutierrez, Camila; Adasme-Carreño, Francisco; Ryde, Ulf

    2016-09-01

    We have estimated the binding affinity of three sets of ligands of the heat-shock protein 90 in the D3R grand challenge blind test competition. We have employed four different methods, based on five different crystal structures: first, we docked the ligands to the proteins with induced-fit docking with the Glide software and calculated binding affinities with three energy functions. Second, the docked structures were minimised in a continuum solvent and binding affinities were calculated with the MM/GBSA method (molecular mechanics combined with generalised Born and solvent-accessible surface area solvation). Third, the docked structures were re-optimised by combined quantum mechanics and molecular mechanics (QM/MM) calculations. Then, interaction energies were calculated with quantum mechanical calculations employing 970-1160 atoms in a continuum solvent, combined with energy corrections for dispersion, zero-point energy and entropy, ligand distortion, ligand solvation, and an increase of the basis set to quadruple-zeta quality. Fourth, relative binding affinities were estimated by free-energy simulations, using the multi-state Bennett acceptance-ratio approach. Unfortunately, the results were varying and rather poor, with only one calculation giving a correlation to the experimental affinities larger than 0.7, and with no consistent difference in the quality of the predictions from the various methods. For one set of ligands, the results could be strongly improved (after experimental data were revealed) if it was recognised that one of the ligands displaced one or two water molecules. For the other two sets, the problem is probably that the ligands bind in different modes than in the crystal structures employed or that the conformation of the ligand-binding site or the whole protein changes.

  16. Binding-affinity predictions of HSP90 in the D3R Grand Challenge 2015 with docking, MM/GBSA, QM/MM, and free-energy simulations

    Science.gov (United States)

    Misini Ignjatović, Majda; Caldararu, Octav; Dong, Geng; Muñoz-Gutierrez, Camila; Adasme-Carreño, Francisco; Ryde, Ulf

    2016-09-01

    We have estimated the binding affinity of three sets of ligands of the heat-shock protein 90 in the D3R grand challenge blind test competition. We have employed four different methods, based on five different crystal structures: first, we docked the ligands to the proteins with induced-fit docking with the Glide software and calculated binding affinities with three energy functions. Second, the docked structures were minimised in a continuum solvent and binding affinities were calculated with the MM/GBSA method (molecular mechanics combined with generalised Born and solvent-accessible surface area solvation). Third, the docked structures were re-optimised by combined quantum mechanics and molecular mechanics (QM/MM) calculations. Then, interaction energies were calculated with quantum mechanical calculations employing 970-1160 atoms in a continuum solvent, combined with energy corrections for dispersion, zero-point energy and entropy, ligand distortion, ligand solvation, and an increase of the basis set to quadruple-zeta quality. Fourth, relative binding affinities were estimated by free-energy simulations, using the multi-state Bennett acceptance-ratio approach. Unfortunately, the results were varying and rather poor, with only one calculation giving a correlation to the experimental affinities larger than 0.7, and with no consistent difference in the quality of the predictions from the various methods. For one set of ligands, the results could be strongly improved (after experimental data were revealed) if it was recognised that one of the ligands displaced one or two water molecules. For the other two sets, the problem is probably that the ligands bind in different modes than in the crystal structures employed or that the conformation of the ligand-binding site or the whole protein changes.

  17. Grandes cocinas

    Directory of Open Access Journals (Sweden)

    García de Castro, Emilio

    1957-11-01

    Full Text Available Se describen en este artículo una serie de aparatos para grandes cocinas, vistos por los autores durante un rápido viaje por Alemania. Aprovechando los datos obtenidos se analizan brevemente las necesidades de una gran cocina moderna, comentando los planos de las instalaciones en varios hoteles o instituciones de todo el mundo. La mayoría de la información.

  18. Students Turned Off by Turnitin? Perception of Plagiarism and Collusion by Undergraduate Bioscience Students

    Science.gov (United States)

    Thompsett, Andrew; Ahluwalia, Jatinder

    2010-01-01

    Research on undergraduate bioscience students and the incidence of plagiarism is still in its infancy and a key problem arises in gauging the perception of undergraduate students on plagiarism and collusion in biosciences subjects because of the lack of empirical data. The aim of this study was to provide qualitative data on the perceptions of…

  19. 75 FR 64733 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use); Safflower Seed Meal

    Science.gov (United States)

    2010-10-20

    ... HUMAN SERVICES Food and Drug Administration Arcadia Biosciences, Inc.; Filing of Food Additive Petition... proposing that the food additive regulations be amended to provide for the safe use of seed meal from a... is given that a food additive petition (FAP 2267) has been filed by Arcadia Biosciences, Inc.,...

  20. Reflective writing as a tool for assessing teamwork in bioscience: insights into student performance and understanding of teamwork.

    Science.gov (United States)

    Mayne, Lynne

    2012-07-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly evolving competitive work place and align with the needs of industry. This creates a challenge, how do we develop generic capabilities without losing discipline content. This report analyses teamwork projects embedded in an undergraduate Biotechnology degree designed to promote teamwork skills along with a deeper understanding of the underpinning biochemistry. Student reflective writing was used to capture students' understanding and experience of teamwork as well as provide insight into their metacognition. The analysis demonstrates that 73% of Year 3 and 93% of Year 4 students were capable of learning about teamwork through reflective writing. While the importance of frequent high quality communication was a common theme, evidence suggests that many students were unsophisticated in their use of communication software. The analysis also highlighted the depth of metacognition that underpins successful team function and the significant weaknesses in self-insight some students possess. These findings challenge assumptions regarding student capacity for leadership and the ability of some students to contribute to successful team outcomes. It is essential for the design of teamwork experiences to fully understand the competencies that underlie teamwork, the metacognitive processes required, and ensure that assessments are fair and measure individual academic performance.

  1. Applications of computational tools in biosciences and medical engineering

    CERN Document Server

    Altenbach, Holm

    2015-01-01

     This book presents the latest developments and applications of computational tools related to the biosciences and medical engineering. It also reports the findings of different multi-disciplinary research projects, for example, from the areas of scaffolds and synthetic bones, implants and medical devices, and medical materials. It is also shown that the application of computational tools often requires mathematical and experimental methods. Computational tools such as the finite element methods, computer-aided design and optimization as well as visualization techniques such as computed axial tomography open up completely new research fields that combine the fields of engineering and bio/medical. Nevertheless, there are still hurdles since both directions are based on quite different ways of education. Often even the “language” can vary from discipline to discipline.

  2. Final report on grand challenge LDRD project : a revolution in lighting : building the science and technology base for ultra-efficient solid-state lighting.

    Energy Technology Data Exchange (ETDEWEB)

    Copeland, Robert Guild; Mitchell, Christine Charlotte; Follstaedt, David Martin; Lee, Stephen Roger; Shul, Randy John; Fischer, Arthur Joseph; Chow, Weng Wah Dr.; Myers, Samuel Maxwell, Jr.; Thoma, Steven George; Gee, James Martin; Coltrin, Michael Elliott; Burdick, Brent A.; Salamone, Angelo, L., Jr.; Hadley, G. Ronald; Elliott, Russell D.; Campbell, Jonathan M.; Abrams, Billie Lynn; Wendt, Joel Robert; Pawlowski, Roger Patrick; Simpson, Regina Lynn; Kurtz, Steven Ross; Cole, Phillip James; Fullmer, Kristine Wanta; Seager, Carleton Hoover; Bogart, Katherine Huderle Andersen; Biefeld, Robert Malcolm; Kerley, Thomas M.; Norman, Adam K.; Tallant, David Robert; Woessner, Stephen Matthew; Figiel, Jeffrey James; Moffat, Harry K.; Provencio, Paula Polyak; Emerson, John Allen; Kaplar, Robert James; Wilcoxon, Jess Patrick; Waldrip, Karen Elizabeth; Rohwer, Lauren Elizabeth Shea; Cross, Karen Charlene; Wright, Alan Francis; Gonzales, Rene Marie; Salinger, Andrew Gerhard; Crawford, Mary Hagerott; Garcia, Marie L.; Allen, Mark S.; Southwell, Edwin T. (Perspectives, Sedona, AZ); Bauer, Tom M.; Monson, Mary Ann; Tsao, Jeffrey Yeenien; Creighton, James Randall; Allerman, Andrew Alan; Simmons, Jerry A.; Boyack, Kevin W.; Jones, Eric Daniel; Moran, Michael P.; Pinzon, Marcia J. (Perspectives, Sedona, AZ); Pinson, Ariane O. (Perspectives, Sedona, AZ); Miksovic, Ann E. (Perspectives, Sedona, AZ); Wang, George T.; Ashby, Carol Iris Hill; Missert, Nancy A.; Koleske, Daniel David; Rahal, Nabeel M.

    2004-06-01

    This SAND report is the final report on Sandia's Grand Challenge LDRD Project 27328, 'A Revolution in Lighting -- Building the Science and Technology Base for Ultra-Efficient Solid-state Lighting.' This project, which for brevity we refer to as the SSL GCLDRD, is considered one of Sandia's most successful GCLDRDs. As a result, this report reviews not only technical highlights, but also the genesis of the idea for Solid-state Lighting (SSL), the initiation of the SSL GCLDRD, and the goals, scope, success metrics, and evolution of the SSL GCLDRD over the course of its life. One way in which the SSL GCLDRD was different from other GCLDRDs was that it coincided with a larger effort by the SSL community - primarily industrial companies investing in SSL, but also universities, trade organizations, and other Department of Energy (DOE) national laboratories - to support a national initiative in SSL R&D. Sandia was a major player in publicizing the tremendous energy savings potential of SSL, and in helping to develop, unify and support community consensus for such an initiative. Hence, our activities in this area, discussed in Chapter 6, were substantial: white papers; SSL technology workshops and roadmaps; support for the Optoelectronics Industry Development Association (OIDA), DOE and Senator Bingaman's office; extensive public relations and media activities; and a worldwide SSL community website. Many science and technology advances and breakthroughs were also enabled under this GCLDRD, resulting in: 55 publications; 124 presentations; 10 book chapters and reports; 5 U.S. patent applications including 1 already issued; and 14 patent disclosures not yet applied for. Twenty-six invited talks were given, at prestigious venues such as the American Physical Society Meeting, the Materials Research Society Meeting, the AVS International Symposium, and the Electrochemical Society Meeting. This report contains a summary of these science and technology

  3. Single vesicle biochips for ultra-miniaturized nanoscale fluidics and single molecule bioscience

    DEFF Research Database (Denmark)

    Christensen, Andreas Lauge; Lohr, Christina; Christensen, Sune M.;

    2013-01-01

    , their fabrication via controlled self-assembly, and their characterization using fluorescence microscopy. We also highlight their applications in selected fields such as nanofluidics and single molecule bioscience. Despite their great potential for improved biocompatibility, extreme miniaturization and high...

  4. MUSC Environmental Biosciences Program First Quarter Report May - June, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr

    2002-07-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC02-98CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific program, employing a range of research initiatives to identify, study and resolve environmental health risk issues. These initiatives are consistent with the Medical University's role as a comprehensive state-supported health sciences institution and the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable the Medical University to be a national resource for the scientific investigation of environmental health issues. EBP's success in convening worldwide scientific expertise is due in part to the inherent credibility the Medical University brings to the process of addressing these complex issues.

  5. Environmental Biosciences Program Third Quarter Report, Year 2

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2005-03-31

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene (TCE), polychlorinated biphenyls (PCBs), and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  6. Environmental Biosciences Program Quarterly Report for Year 3

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence C. Mohr, M.D.

    2006-04-30

    In May 2002, the United States Department of Energy (DOE) signed Assistance Instrument Number DE-FC09-02CH11109 with the Medical University of South Carolina (MUSC) to support the Environmental Biosciences Program (EBP). This funding instrument replaces DOE Assistance Instrument Number DE-FC02-98CH10902. EBP is an integrated, multidisciplinary scientific research program, employing a range of research initiatives to identify, study and resolve environmental health risks. These initiatives are consistent with the MUSC role as a comprehensive state-supported health sciences institution and with the nation's need for new and better approaches to the solution of a complex and expansive array of environment-related health problems. The intrinsic capabilities of a comprehensive health sciences institution enable MUSC to be a national resource for the scientific investigation of environmental health issues. EBPs success as a nationally prominent research program is due, in part, to its ability to task-organize scientific expertise from multiple disciplines in addressing these complex problems. Current research projects have focused EBP talent and resources on providing the scientific basis for risk-based standards, risk-based decision making and the accelerated clean-up of widespread environmental hazards. These hazards include trichloroethylene and low-dose ionizing radiation. A project is also being conducted in the use of geographical information system technology to analyze population health risks related to environmental hazards as a tool for risk-based decision-making.

  7. Estado de Direito e seus Quatro Grandes Desafios na América Latina na Atualidade: uma leitura a / State of Law and its four great challenges on actual Latin America: a reading from Brazilian's reality

    Directory of Open Access Journals (Sweden)

    Gilmar Antônio Bedin

    2010-12-01

    Full Text Available O presente texto apresenta as dimensões fundamentais do Estado de Direito em seu sentido jurídico-institucional e verifica se essas dimensões foram acolhidas pelas ordens jurídicas dos países da América Latina, em especial pela ordem jurídica brasileira. Além disso, o trabalho analisa os quatro grandes desafios dessaestrutura jurídico-institucional na atualidade nos países latino-americanos.Abstract:This paper presents the State of Law fundamental dimensions in its institutional-legal sense, and analyzes if these dimensions were adopted by the legal systems of the Latin American countries, especially by the Brazilian legal system. This paper also investigates the current four major challenges of this institutional legal framework in Latin America.

  8. Automatic categorization of diverse experimental information in the bioscience literature

    Directory of Open Access Journals (Sweden)

    Fang Ruihua

    2012-01-01

    Full Text Available Abstract Background Curation of information from bioscience literature into biological knowledge databases is a crucial way of capturing experimental information in a computable form. During the biocuration process, a critical first step is to identify from all published literature the papers that contain results for a specific data type the curator is interested in annotating. This step normally requires curators to manually examine many papers to ascertain which few contain information of interest and thus, is usually time consuming. We developed an automatic method for identifying papers containing these curation data types among a large pool of published scientific papers based on the machine learning method Support Vector Machine (SVM. This classification system is completely automatic and can be readily applied to diverse experimental data types. It has been in use in production for automatic categorization of 10 different experimental datatypes in the biocuration process at WormBase for the past two years and it is in the process of being adopted in the biocuration process at FlyBase and the Saccharomyces Genome Database (SGD. We anticipate that this method can be readily adopted by various databases in the biocuration community and thereby greatly reducing time spent on an otherwise laborious and demanding task. We also developed a simple, readily automated procedure to utilize training papers of similar data types from different bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these data types for a single database. This approach has great significance because for some data types, especially those of low occurrence, a single corpus often does not have enough training papers to achieve satisfactory performance. Results We successfully tested the method on ten data types from WormBase, fifteen data types from FlyBase and three data types from Mouse Genomics Informatics (MGI. It is being used in

  9. On a Grand Scale

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The futuristic National Grand Theater of China opened its grand curtains for a test show in September. Will this costly addition to Beijing’s entertainment scene be affordable to ordinary audiences?

  10. Nuclear medicine department activity facing major public health challenges in France; Activite des services de medecine nucleaire face aux grands enjeux de sante publique en France

    Energy Technology Data Exchange (ETDEWEB)

    Baulieu, J.L. [Hopital Bretonneau, CHU de Tours, Unite de Medecine Nucleaire, 37 - Tours (France); Mundler, O. [CHU la Timone, Service Central de Biophysique et Medecine Nucleaire, 13 - Marseille (France)

    2007-12-15

    A national survey was made at the 2008 la Baule Symposium 'nuclear medicine facing major public health challenges'. The aim was to evaluate the activity in the fields of clinical specialities involved in these challenges : cancerology, cardiology and neurology. The response rate was 62%. The total number of PET scans performed in France during the year 2007 was about 100,000 including 97.5% of cancer indications. The mean number of PET scans per center was 1285, with a maximum of 3500 scans. The first indications were lung cancer (27%), lymphoma (20%) and colorectal cancer (14%). The registered number of cardiac examinations was 170,387 extrapolated to a total number of about 250,000 examinations in one year. The number of registered brain SPECT was 11,215 corresponding to about 100 examinations per center in one year. The survey pointed out large variations of PET activity between centers and suggested potentialities in extending and diversifying the field of PET. Brain scintigraphy appeared as a minor sector out of proportion with the challenge of degenerative brain pathology. Performing again these evaluations in the next years should allow to better describe the capabilities of nuclear medicine to face the major challenges and the evolution of public health.

  11. Reflective Writing as a Tool for Assessing Teamwork in Bioscience: Insights into Student Performance and Understanding of Teamwork

    Science.gov (United States)

    Mayne, Lynne

    2012-01-01

    To ensure a modern bioscience curriculum that responds to the current needs of stakeholders, there is a need to embed a range of generic capabilities that enables graduates to succeed in and contribute to a rapidly changing world, as well as building strong bioscience skills and knowledge. The curriculum must also prepare students for a rapidly…

  12. Reflective Practice: A Place in Enhancing Learning in the Undergraduate Bioscience Teaching Laboratory?

    Science.gov (United States)

    Parry, Damian; Walsh, Cathy; Larsen, Carl; Hogan, Joanne

    2012-01-01

    Bioscience employers demand graduates with better practical competence. It is our supposition that, although undesirable, student learning is assessment driven and this is leading students to simply go through the motions in the practical setting (whether field work or laboratory based). In this intervention a Critical Incident Report was…

  13. 77 FR 56175 - Arcadia Biosciences, Inc.; Filing of Food Additive Petition (Animal Use)

    Science.gov (United States)

    2012-09-12

    ... Additive Petition (Animal Use) AGENCY: Food and Drug Administration, HHS. ACTION: Notice of petition... petition proposing that the food additive regulations be amended to provide for the safe use in dry dog... is given that a food additive petition (FAP 2275) has been filed by Arcadia Biosciences, Inc.,...

  14. Design of an Integrated Team Project as Bachelor Thesis in Bioscience Engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-01-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the…

  15. Technology Transfer in HEIs: A Case Study of Bioscience Commercialization at the University of Warwick

    Science.gov (United States)

    Gohir, Tas; Palmer, Grier

    2005-01-01

    The UK's bioscience research base is one of the country's genuine long-term economic assets. It is critically important for the UK not to repeat past mistakes, when financial exploitation of innovative and groundbreaking bioresearch went overseas. This study reviews commercialization from the Department of Biological Sciences at Warwick University…

  16. Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

    Science.gov (United States)

    Perry, Matthew D.; Abi‐Gerges, Najah; Couderc, Jean‐Philippe; Fermini, Bernard; Hancox, Jules C.; Knollmann, Bjorn C.; Mirams, Gary R.; Skinner, Jon; Zareba, Wojciech; Vandenberg, Jamie I.

    2016-01-01

    Abstract Risk stratification in the context of sudden cardiac death has been acknowledged as one of the major challenges facing cardiology for the past four decades. In recent years, the advent of high performance computing has facilitated organ‐level simulation of the heart, meaning we can now examine the causes, mechanisms and impact of cardiac dysfunction in silico. As a result, computational cardiology, largely driven by the Physiome project, now stands at the threshold of clinical utility in regards to risk stratification and treatment of patients at risk of sudden cardiac death. In this white paper, we outline a roadmap of what needs to be done to make this translational step, using the relatively well‐developed case of acquired or drug‐induced long QT syndrome as an exemplar case. PMID:27060987

  17. Scientific Grand Challenges: Discovery In Basic Energy Sciences: The Role of Computing at the Extreme Scale - August 13-15, 2009, Washington, D.C.

    Energy Technology Data Exchange (ETDEWEB)

    Galli, Giulia [Univ. of California, Davis, CA (United States). Workshop Chair; Dunning, Thom [Univ. of Illinois, Urbana, IL (United States). Workshop Chair

    2009-08-13

    The U.S. Department of Energy’s (DOE) Office of Basic Energy Sciences (BES) and Office of Advanced Scientific Computing Research (ASCR) workshop in August 2009 on extreme-scale computing provided a forum for more than 130 researchers to explore the needs and opportunities that will arise due to expected dramatic advances in computing power over the next decade. This scientific community firmly believes that the development of advanced theoretical tools within chemistry, physics, and materials science—combined with the development of efficient computational techniques and algorithms—has the potential to revolutionize the discovery process for materials and molecules with desirable properties. Doing so is necessary to meet the energy and environmental challenges of the 21st century as described in various DOE BES Basic Research Needs reports. Furthermore, computational modeling and simulation are a crucial complement to experimental studies, particularly when quantum mechanical processes controlling energy production, transformations, and storage are not directly observable and/or controllable. Many processes related to the Earth’s climate and subsurface need better modeling capabilities at the molecular level, which will be enabled by extreme-scale computing.

  18. Division of energy biosciences: Annual report and summaries of FY 1995 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.

  19. The molecular biology revolution and the rise of bioscience megacentres in North America and Europe

    OpenAIRE

    Philip Cooke

    2004-01-01

    This paper focuses on 'triple helix' effects in biosciences. Scientific change can have profound socioeconomic effects. The molecular biology revolution tilted pharmaceuticals production away from its fine chemistry path dependence into microbiology and biotechnology. The key to any triple helix effects has thus shifted to universities and spinouts buttressed with burgeoning public funding, leaving 'big pharma' increasingly playing the role of licenser and marketer of bought-in therapeutic tr...

  20. Grand Challenges: Nanotechnology and the Social Studies

    Science.gov (United States)

    Manfra, Meghan McGlinn

    2013-01-01

    This article explores a multidisciplinary lesson on nanotechnology that can provide an effective means for teaching about both STEM and social studies topics. This approach encourages students to consider the "role that science and technology play in our lives and in our cultures." The extraordinary promise of nanotechnology, however, is…

  1. Grand challenge in Biomaterials-wound healing

    Science.gov (United States)

    Salamone, Joseph C.; Salamone, Ann Beal; Swindle-Reilly, Katelyn; Leung, Kelly Xiaoyu-Chen; McMahon, Rebecca E.

    2016-01-01

    Providing improved health care for wound, burn and surgical patients is a major goal for enhancing patient well-being, in addition to reducing the high cost of current health care treatment. The introduction of new and novel biomaterials and biomedical devices is anticipated to have a profound effect on the future improvement of many deleterious health issues. This publication will discuss the development of novel non-stinging liquid adhesive bandages in healthcare applications developed by Rochal Industries. The scientists/engineers at Rochal have participated in commercializing products in the field of ophthalmology, including rigid gas permeable contact lenses, soft hydrogel contact lenses, silicone hydrogel contact lenses, contact lens care solutions and cleaners, intraocular lens materials, intraocular controlled drug delivery, topical/intraocular anesthesia, and in the field of wound care, as non-stinging, spray-on liquid bandages to protect skin from moisture and body fluids and medical adhesive-related skin injuries. Current areas of entrepreneurial activity at Rochal Industries pertain to the development of new classes of biomaterials for wound healing, primarily in regard to microbial infection, chronic wound care, burn injuries and surgical procedures, with emphasis on innovation in product creation, which include cell-compatible substrates/scaffolds for wound healing, antimicrobial materials for opportunistic pathogens and biofilm reduction, necrotic wound debridement, scar remediation, treatment of diabetic ulcers, amelioration of pressure ulcers, amelioration of neuropathic pain and adjuvants for skin tissue substitutes. PMID:27047680

  2. Aligning innovation with grand societal challenges

    DEFF Research Database (Denmark)

    Ricard, Lykke Margot

    2016-01-01

    This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support for the ......This paper investigates the European Technology Platforms (ETPs) in wind power and in CO2 capture and storage supported by the European Commission (EC). It examines the role of these Platforms in shaping the trajectory of European energy technology policy, and shows that the EC’s support...

  3. Navigating Bioethical Waters: Two Pilot Projects in Problem-Based Learning for Future Bioscience and Biotechnology Professionals.

    Science.gov (United States)

    Berry, Roberta M; Levine, Aaron D; Kirkman, Robert; Blake, Laura Palucki; Drake, Matthew

    2016-12-01

    We believe that the professional responsibility of bioscience and biotechnology professionals includes a social responsibility to contribute to the resolution of ethically fraught policy problems generated by their work. It follows that educators have a professional responsibility to prepare future professionals to discharge this responsibility. This essay discusses two pilot projects in ethics pedagogy focused on particularly challenging policy problems, which we call "fractious problems". The projects aimed to advance future professionals' acquisition of "fractious problem navigational" skills, a set of skills designed to enable broad and deep understanding of fractious problems and the design of good policy resolutions for them. A secondary objective was to enhance future professionals' motivation to apply these skills to help their communities resolve these problems. The projects employed "problem based learning" courses to advance these learning objectives. A new assessment instrument, "Skills for Science/Engineering Ethics Test" (SkillSET), was designed and administered to measure the success of the courses in doing so. This essay first discusses the rationale for the pilot projects, and then describes the design of the pilot courses and presents the results of our assessment using SkillSET in the first pilot project and the revised SkillSET 2.0 in the second pilot project. The essay concludes with discussion of observations and results.

  4. Grand Hotel prijutil hudozhnikov

    Index Scriptorium Estoniae

    2004-01-01

    Raadioajakirjanik Lea Veelmaa lindistas "Kunstikanali" 2004. a. esimese saate Grand Hotel Viljandis. Saatekülaliseks oli maalikunstnik Andres Tolts. Toltsi kaheksa akrüülmaali on eksponeeritud hotelli fuajees ja restoranis

  5. Google Earth Grand Tour Themes

    Science.gov (United States)

    De Paor, D. G.; Whitmeyer, S. J.; Bentley, C.; Dordevic, M. M.

    2014-12-01

    As part of an NSF TUES Type 3 project entitled "Google Earth for Onsite and Distance Education (GEODE)," we are assembling a "Grand Tour" of locations on Earth and other terrestrial bodies that every geoscience student should know about and visit at least in virtual reality. Based on feedback from colleagues at previous meetings, we have identified nine Grand Tour themes: "Plates and Plumes," "Rocks and Regions," "Geology Through Time," "The Mapping Challenge*," "U.S. National Parks*," "The Magical Mystery Tour*," "Resources and Hazards," "Planets and Moons," and "Top of the Pops." Themes marked with an asterisk are most developed at this stage and will be demonstrated in real time. The Mapping Challenge invites students to trace geological contacts, measure bedding strike and dip and the plunge, trend, and facing of a fold. There is an advanced tool for modeling periclinal folds. The challenge is presented in a game-like format with an emphasis on puzzle-solving that will appeal to students regardless of gender. For the tour of U.S. national parks, we divided the most geologically important parks into four groups—Western Pacific, West Coast, Rockies, and East Coast. We are combining our own team's GigaPan imagery with imagery already available on the Internet. There is a great deal of imagery just waiting to be annotated for geological education purposes. The Magical Mystery Tour takes students to Google Streetview locations selected by instructors. Students are presented with questions or tasks and are given automatic feedback. Other themes are under development. Within each theme, we are crowd-sourcing contributions from colleagues and inviting colleagues to vote for or against proposed locations and student interactions. The GEODE team includes the authors and: Heather Almquist, Stephen Burgin, Cinzia Cervato, Gene Cooper, Paul Karabinos, Terry Pavlis, Jen Piatek, Bill Richards, Jeff Ryan, Ron Schott, Kristen St. John, and Barb Tewksbury.

  6. Design of an integrated team project as bachelor thesis in bioscience engineering

    Science.gov (United States)

    Peeters, Marie-Christine; Londers, Elsje; Van der Hoeven, Wouter

    2014-11-01

    Following the decision at the KU Leuven to implement the educational concept of guided independent learning and to encourage students to participate in scientific research, the Faculty of Bioscience Engineering decided to introduce a bachelor thesis. Competencies, such as communication, scientific research and teamwork, need to be present in the design of this thesis. Because of the high number of students and the multidisciplinary nature of the graduates, all research divisions of the faculty are asked to participate. The yearly surveys and hearings were used for further optimisation. The actual design of this bachelor thesis is presented and discussed in this paper.

  7. Grand unification of neutron stars.

    Science.gov (United States)

    Kaspi, Victoria M

    2010-04-20

    The last decade has shown us that the observational properties of neutron stars are remarkably diverse. From magnetars to rotating radio transients, from radio pulsars to isolated neutron stars, from central compact objects to millisecond pulsars, observational manifestations of neutron stars are surprisingly varied, with most properties totally unpredicted. The challenge is to establish an overarching physical theory of neutron stars and their birth properties that can explain this great diversity. Here I survey the disparate neutron stars classes, describe their properties, and highlight results made possible by the Chandra X-Ray Observatory, in celebration of its 10th anniversary. Finally, I describe the current status of efforts at physical "grand unification" of this wealth of observational phenomena, and comment on possibilities for Chandra's next decade in this field.

  8. Grand unification of neutron stars

    Science.gov (United States)

    Kaspi, Victoria M.

    2010-01-01

    The last decade has shown us that the observational properties of neutron stars are remarkably diverse. From magnetars to rotating radio transients, from radio pulsars to isolated neutron stars, from central compact objects to millisecond pulsars, observational manifestations of neutron stars are surprisingly varied, with most properties totally unpredicted. The challenge is to establish an overarching physical theory of neutron stars and their birth properties that can explain this great diversity. Here I survey the disparate neutron stars classes, describe their properties, and highlight results made possible by the Chandra X-Ray Observatory, in celebration of its 10th anniversary. Finally, I describe the current status of efforts at physical “grand unification” of this wealth of observational phenomena, and comment on possibilities for Chandra’s next decade in this field. PMID:20404205

  9. Grand Unification in Neutron Stars

    CERN Document Server

    Kaspi, Victoria M

    2010-01-01

    The last decade has shown us that the observational properties of neutron stars are remarkably diverse. From magnetars to rotating radio transients, from radio pulsars to `isolated neutron stars,' from central compact objects to millisecond pulsars, observational manifestations of neutron stars are surprisingly varied, with most properties totally unpredicted. The challenge is to establish an overarching physical theory of neutron stars and their birth properties that can explain this great diversity. Here I survey the disparate neutron stars classes, describe their properties, and highlight results made possible by the Chandra X-ray Observatory, in celebration of its tenth anniversary. Finally, I describe the current status of efforts at physical `grand unification' of this wealth of observational phenomena, and comment on possibilities for Chandra's next decade in this field.

  10. Ontologies and standards in bioscience research: for machine or for human

    Directory of Open Access Journals (Sweden)

    Huaiyu eMi

    2011-02-01

    Full Text Available Ontologies and standards are very important parts of today’s bioscience research. With the rapid increase of biological knowledge, they provide mechanisms to better store and represent data in a controlled and structured way, so that scientists can share the data, and utilize a wide variety of software and tools to manage and analyze the data. Most of these standards are initially designed for computers to access large amounts of data that are difficult for human biologists to handle, and it is important to keep in mind that ultimately biologists are going to produce and interpret the data. While ontologies and standards must follow strict semantic rules that may not be familiar to biologists, effort must be spent to lower the learning barrier by involving biologists in the process of development, and by providing software and tool support. A standard will not succeed without support from the wider bioscience research community. Thus, it is crucial that these standards be designed not only for machines to read, but also to be scientifically accurate and intuitive to human biologists.

  11. Division of Energy Biosciences annual report and summaries of FY 1996 activities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-04-01

    The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicals by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.

  12. Diez grandes arquitectos

    OpenAIRE

    Dominguez Uceta, Enrique

    2009-01-01

    Selección de 10 museos de arquitectura contemporánea realizada con Rafael Moneo y Juan Miguel Hernández León, con las mejores obras museísticas de 10 grandes arquitectos. Los edificios, de Wright, Sert, Scarpa, Piano & Rogers, Kahn, Moneo, Piano, Gehry, Siza y Herzog & de Meuron, son descritos y analizados.

  13. Asymptotically Safe Grand Unification

    DEFF Research Database (Denmark)

    Bajc, Borut; Sannino, Francesco

    2016-01-01

    for a broad class of prime candidates of phenomenologically relevant supersymmetric grand unified theories. We also uncover candidates passing these tests, which have either exotic matter or contain one field decoupled from the superpotential. The latter class of theories contains a model with the minimal...... matter content required by phenomenology....

  14. Asymptotically Safe Grand Unification

    CERN Document Server

    Bajc, Borut

    2016-01-01

    Phenomenologically appealing supersymmetric grand unified theories have large gauge representations and thus are not asymptotically free. Their ultraviolet validity is limited by the appearance of a Landau pole well before the Planck scale. One could hope that these theories save themselves, before the inclusion of gravity, by generating an interacting ultraviolet fixed point, similar to the one recently discovered in non-supersymmetric gauge-Yukawa theories. Employing a-maximization, a-theorem, unitarity bounds, as well as positivity of other central charges we nonperturbatively rule out this possibility for a broad class of prime candidates of phenomenologically relevant supersymmetric grand unified theories. We also uncover candidates passing these tests, which have either exotic matter or contain one field decoupled from the superpotential. The latter class of theories contains a model with the minimal matter content required by phenomenology.

  15. Asymptotically safe grand unification

    Science.gov (United States)

    Bajc, Borut; Sannino, Francesco

    2016-12-01

    Phenomenologically appealing supersymmetric grand unified theories have large gauge representations and thus are not asymptotically free. Their ultraviolet validity is limited by the appearance of a Landau pole well before the Planck scale. One could hope that these theories save themselves, before the inclusion of gravity, by generating an interacting ultraviolet fixed point, similar to the one recently discovered in non-supersymmetric gauge-Yukawa theories. Employing a-maximization, a-theorem, unitarity bounds, as well as positivity of other central charges we nonperturbatively rule out this possibility for a broad class of prime candidates of phenomenologically relevant supersymmetric grand unified theories. We also uncover candidates passing these tests, which have either exotic matter or contain one field decoupled from the superpotential. The latter class of theories contains a model with the minimal matter content required by phenomenology.

  16. LA GRANDE DESCENTE

    CERN Multimedia

    The first endcap disc of CMS being lowered slowly and carefully 100 m underground into the experimental cavern. The disc is one of 15 large pieces to make the grand descent.  The uniquely shaped slice, 16 m high, about 50 cm thick weighs 400 tonnes. The two HF that were lowered earlier in November can also be seen in the foreground and background.  

  17. Grand alliance HDTV

    Science.gov (United States)

    Petajan, Eric D.

    1995-12-01

    Terrestrial broadcast television in the United States has remained essentially unchanged in the last fifty years except for the addition of color and stereo sound. Today, personal computers are addressing the need for random access of high resolution images and CD quality audio. Furthermore, advances in digital video compression and digital communication technology have cleared the way toward offering high resolution video and audio services to consumers using traditional analog communications channels. In 1987, the U.S. Federal Communications Commission (FCC) chartered an advisory committee to recommend an advanced television system for the United States. From 1990 to 1992, the Advanced Television Test Center tested four all-digital systems, one analog High Definition Television (HDTV) system, and one enhancement NTSC system using broadcast and cable television environment simulators. The formation of the HDTV Grand Alliance in May of 1993 resulted from the withdrawal of the only analog HDTV system from the competition and a stalemate between the other four all- digital systems. The HDTV Grand Alliance system is composed of the best components from previously competing digital systems demonstrated to the FCC. Moving Pictures Experts Group (MPEG-2) syntax is used with novel encoding techniques to deliver a set of video scanning formats for a variety of applications. This paper describes the important features and concepts embodied in the HDTV Grand Alliance system.

  18. Effect of A-Level Subject Choice and Entry Tariff on Final Degree and Level 1 Performance in Biosciences

    Science.gov (United States)

    King, Nicola C.; Aves, Stephen J.

    2012-01-01

    Following the publication of the higher education white paper increasing entry tariff and widening participation have become even more important issues for universities. This report examines the relationship between entry tariff and undergraduate achievement in Biosciences at the University of Exeter. We show that, whilst there is a significant…

  19. Production of Doctorates in the Biosciences, 1975-1980: An Experimental Forecast. Higher Education Panel Reports, No. 34.

    Science.gov (United States)

    Atelsek, Frank J.; Gomberg, Irene L.

    A survey was undertaken in 1976 to obtain short-term estimates of doctorate production directly from the heads of the science departments involved. These biosciences departments were surveyed in the 235 member institutions of the Higher Education Panel that grant doctorates: anatomy, biochemistry, biology, biometry/biostatistics/biomathematics,…

  20. Googling your genes: personal genomics and the discourse of citizen bioscience in the network age

    Directory of Open Access Journals (Sweden)

    Marina Levina

    2010-03-01

    Full Text Available In this essay, I argue that the rise of personal genomics is technologically, economically, and most importantly, discursively tied to the rise of network subjectivity, an imperative of which is an understanding of self as always already a subject in the network. I illustrate how personal genomics takes full advantage of social media technology and network subjectivity to advertise a new way of doing research that emphasizes collaboration between researchers and its members. Sharing one’s genetic information is considered to be an act of citizenship, precisely because it is good for the network. Here members are encouraged to think of themselves as dividuals, or nodes, in the network and their actions acquire value based on that imperative. Therefore, citizen bioscience is intricately tied, both in discourse and practices, to the growth of the network in the age of new media.

  1. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience.

    Science.gov (United States)

    Aicardi, Christine

    2016-02-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a 'cross-worlds influencer' who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise 'un-disciplined' new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against 'vitalism': anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of 'doing science' and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: 'follow the cross-worlds influencers' who worked to build and organise these semi-institutional gatherings and institutional structures.

  2. Francis Crick, cross-worlds influencer: A narrative model to historicize big bioscience

    Science.gov (United States)

    Aicardi, Christine

    2016-01-01

    The essay is an empirical case study of famed British scientist Francis Crick. Viewing him as a ‘cross-worlds influencer’ who was moreover dedicated to a cause, I have tried to understand how these two characteristics influenced the trajectory of his long career and how they shaped his contributions to the diverse research fields in which he was active, and concluded that these characteristics reconfigure Crick's career into a coherent whole. First, I identify a major thread running through Crick's career: helping organise ‘un-disciplined’ new research fields, and show that his successive choices were not serendipitous but motivated by what he construed as a crusade against ‘vitalism’: anti-vitalism was a defining driver of his career. I then examine how Crick put his skills as a crossworlds influencer to the service of his cause, by helping organise his chosen fields of intervention. I argue that his activities as a cross-worlds influencer were an integral part of his way of ‘doing science’ and that his contributions to science, neuroscience in particular, should be re-evaluated in this light. This leads me to advance a possible strategy for historians to investigate big bioscience fields. Following Abir-Am, I propose to trace their genealogies back to the fluctuating semi-institutional gatherings and the institutional structures that sustained them. My research on Crick supports the view that such studies can bring insights into the question of why the contours of contemporary big bioscience endeavours have come to be shaped the way they are. Further, the essay provides a heuristic device for approaching these enquiries: ‘follow the cross-worlds influencers’ who worked to build and organise these semi-institutional gatherings and institutional structures. PMID:26383132

  3. Geo synthetics. a remarkable discipline with great achievements in the past and exciting challenges for a bright future; Geosinteticos: una importante disciplina con grandes logros en el pasado y emocionantes retos para un brillante futuro

    Energy Technology Data Exchange (ETDEWEB)

    Giroud, J. P.

    2014-02-01

    This paper presents achievements of the geo synthetics discipline and challenges facing the discipline. The paper shows that one of the main achievements of geo synthetics discipline and challenges facing the discipline. The paper shows that one of the main achievements of geo synthetics is that they have pervaded most branches of geotechnical engineering to the point where it is almost impossible to practice geotechnical engineering without geo synthetics. Then, the paper addresses the challenges facing the geo synthetics discipline. Two major types of challenges are identified: education challenges and technical challenges. Regarding technical challenges, it is recommended that researchers focus on behaviors that are not traditionally considered in geotechnical engineering in order to use geo synthetics to their full potential. Note: this is a significantly expanded version of the keynote paper presented at the 2008 GeoAmericas Conferences. (Author)

  4. Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Denis Alcides-Rezende

    2008-01-01

    Full Text Available The objective of this work is to analyse the integration of information systems and information technology resources in the municipal planning of 14 small cities of Rio Grande do Sul (Brazil. The research methodology consisted of a multiple case study together with a convenient non-probabilistic sample chosen through a research protocol. The results demonstrate the difficulties of these cities to organise the municipal data as well as their struggle for accessibility of information and planning for management and control.

  5. Diet type and challenge by family: 'Lucida Grande', 'Lucida Sans Unicode', sans-serif; font-size: 12px; ">Yersinia ruckeri influence the intestinal microbiota in rainbow trout (family: 'Lucida Grande', 'Lucida Sans Unicode', sans-serif; font-size: 12px; ">Oncorhynchus mykiss)

    DEFF Research Database (Denmark)

    Ingerslev, Hans Christian; Dalsgaard, Inger; Jørgensen, Louise von Gersdorff

    and does it play a protective role in connection to pathogenic challenge? To examine these questions rainbow trout fry were fed two different diets of either a marine or vegetable origin from first feeding and onwards. At a size of about four gram a subset of the fish were bath challenged by Yersinia...... to the type of diet and does further seem to be involved in the immunological response in connection to pathogenic challenge....

  6. Grande Bretagne Hotel Athens

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Grande Bretagne酒店在过去的130年间被认为是雅典的“贵族包厢”。它坐落于市中心最著名的街区之一.对面是宪法广场,国会议院和国家花园,酒店的地理位置非常理想.通过短时间的步行就可以到达附近的高级购物区,餐馆,露天咖啡馆,博物馆和商务区,到目前为止,这家酒店已经接待了很多的国际领导人和知名人士。

  7. Division of Energy Biosciences annual report and summaries of FY 1991 activities

    Energy Technology Data Exchange (ETDEWEB)

    1991-09-01

    As a component of the Department of Energy, the Energy Biosciences (EB) program of the Office of Basic Energy Sciences supports long-term research aimed at addressing energy-related problems utilizing biological systems. There are three main components of the EB program. The first, Primary Biological Energy Conversion, concentrates on research on plant and microbial photosynthesis, but also deals with plant growth control, stress reactions, and interaction with pathogens. The second, Bioconversion of Products, concentrates on utilization of the products of primary energy conversion. Specific examples include biosynthesis of potential fuels or chemicals, biodegradation of lignocellulose into potentially useful compounds, plant/microbe symbiosis, microbial methanogenesis and fermentation. The third main component of the EB program involves providing the basic research infrastructure to support future discoveries. The emphasis here is on investigation of basic genetic mechanisms, both in novel systems and extensively studied systems such as maize; development of critical databases, techniques, and instrumentation; and support of training in areas that are important but underpopulated. Brief descriptions of currently supported research projects are provided. 186 refs., 1 tab (MHB)

  8. Annual report and summaries of FY 1993 activities: Division of Energy Biosciences

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    The mission of the Energy Biosciences program is to generate fundamental information about plants and non-health related microorganisms that will constitute the base for new biotechnologies as well as supply information to improve usages of such organisms in their current form. The collective aims are totally consistent with the Department of Energy`s objectives of developing alternate energy sources, replacements for otherwise fossil energy derived products and providing critical fundamental information for the preservation and restoration of environmental conditions affected by energy related activities. The EB program takes full advantage of its organizational locale in the Office of Basic Energy Sciences to directly interact with such disciplines as Materials Sciences, Chemistry, Engineering and Geosciences to promote cross-disciplinary research and planning activities. One of the major specific objectives of the EB program is to probe the enormous capabilities of the specified organisms to carry out biochemical conversions. The limitation to realization of entirely new products and processes via biotechnology is the lack of basic understanding of natural processes. Such knowledge will then afford the advantage of developing procedures to the benefit of people and their society in providing new products along with providing new employment possibilities. This document consists of abstracts of projects supported in FY 1993.

  9. The impact of attaining the Welsh Baccalaureate Advanced Diploma on academic performance in bioscience higher education

    Science.gov (United States)

    Yhnell, Emma; Wood, Heather; Baker, Mathew; Amici-Dargan, Sheila; Taylor, Chris; Randerson, Peter; Shore, Andrew

    2016-01-01

    Since the introduction of the Welsh Baccalaureate Advanced Diploma Qualification (WBQ) in 2003, an increasing number of students are applying to higher education institutions (HEIs) with this qualification. The advanced-level WBQ is regarded as equivalent to one General Certificate of Education A-Level (GCE A-Level). This study assesses the impact of attaining the WBQ in addition to three GCE A-Levels on overall university degree performance in comparison to attaining four GCE A-Levels, in three cohorts of undergraduate students (Year 1 = 318, Year 2 = 280, Year 3 = 236) studying Biosciences from 2005 to 2011 at a UK HEI. Binary logistic regression was used to compare the academic attainment of students who had achieved four GCE A-Levels to those who had achieved three GCE A-Levels in addition to the WBQ. Comparisons were also made between students who had achieved three GCE A-Levels and those who had achieved three GCE A-Levels in addition to the WBQ. The results suggest that students who achieved the WBQ qualification in its current form, in addition to three GCE A-Levels, performed less well academically in undergraduate studies than those who achieved four GCE A-Levels. Furthermore, this effect was still present when the balance between coursework and examination was considered, and when students who had achieved the WBQ in addition to three GCE A-Levels were compared to students who had achieved three GCE A-Levels.

  10. The integration of the "spirituality in medicine" curriculum into the osteopathic communication curriculum at Kansas City University of Medicine and Biosciences.

    Science.gov (United States)

    Talley, Jan A; Magie, Richard

    2014-01-01

    With grant funding from the John Templeton Spirituality and Medicine Curricular Award to the George Washington Institute for Spirituality and Health, faculty at Kansas City University of Medicine and Biosciences (KCUMB) developed the "Spirituality in Medicine" curriculum. In developing the curriculum, faculty took into consideration competencies required by the Association of American Medical Colleges and qualitative results from surveys of medical school applicants and enrolled students. Strategies for curriculum delivery included lectures, panel discussions, role-playing, and training in the use of a spirituality assessment tool. A majority of the 250 students who received the training in 2010-2011 were able to demonstrate the following competencies: (1) being sensitive to patients' spiritual and cultural needs, (2) assessing patients' and their own spiritual needs, (3) appropriately using chaplain services for patient care, and (4) understanding the effects of health disparities and ethical issues on patient care. Challenges to implementation included a reduction in chaplain availability due to the economic downturn, a lack of student exposure to direct patient care during shadowing, too little religious diversity among chaplains, and changes in assignment schedules. New competencies required by the National Board of Osteopathic Medical Examiners overlap with and help ensure sustainability of the Spirituality in Medicine curriculum. KCUMB leaders have incorporated the use of the spirituality assessment tool into other parts of the curriculum and into service experiences, and they have introduced a new elective in palliative care. Synergistic efforts by faculty leaders for this initiative were critical to the implementation of this curriculum.

  11. Warped Supersymmetric Grand Unification

    CERN Document Server

    Goldberger, W D; Smith, D R; Goldberger, Walter D.; Nomura, Yasunori; Smith, David R.

    2003-01-01

    We construct a realistic model of grand unification in AdS_5 truncated by branes, in which the unified gauge symmetry is broken by boundary conditions and the electroweak scale is generated by the AdS warp factor. We show that the model preserves the successful gauge coupling unification of the 4D MSSM at leading-logarithmic level. Kaluza-Klein towers, including those of XY gauge and colored Higgs multiplets, appear at the TeV scale, while the extra dimension provides natural mechanisms for doublet-triplet splitting and proton decay suppression. In one possible scenario supersymmetry is strongly broken on the TeV brane, in which case the lightest SU(3)_C x SU(2)_L x U(1)_Y gauginos are Dirac fermions, with universal masses at the weak scale, and the mass of the lightest XY gaugino is pushed well below that of the lowest gauge boson KK mode, improving the prospects for its production at the LHC. The bulk Lagrangian possesses a symmetry that we call GUT parity. If GUT parity is exact, the lightest GUT particle,...

  12. Grand slam on cancer.

    Science.gov (United States)

    Gartrell, Nanette

    2014-01-01

    A winner of 59 Grand Slam championships including a record 9 Wimbledon singles titles, Martina Navratilova is the most successful woman tennis player of the modern era. Martina was inducted into the International Tennis Hall of Fame, named "Tour Player of the Year" seven times by the Women's Tennis Association, declared "Female Athlete of the Year" by the Associated Press, and ranked one of the "Top Forty Athletes of All-Time" by Sports Illustrated. Equally accomplished off the court, Martina is an author, philanthropist, TV commentator, and activist who has dedicated her life to educating people about prejudice and stereotypes. After coming out as a lesbian in 1981, Martina became a tireless advocate of equal rights for lesbian, gay, bisexual, and transgender (LGBT) people, and she has contributed generously to the LGBT community. Martina is the author of seven books, including most recently Shape Your Self: My 6-Step Diet and Fitness Plan to Achieve the Best Shape of your Life, an inspiring guide to healthy living and personal fitness. Martina was diagnosed with breast cancer in 2010.

  13. A business case for on-site generation: The BD biosciences pharmingen project

    Energy Technology Data Exchange (ETDEWEB)

    Firestone, Ryan; Creighton, Charles; Bailey, Owen; Marnay, Chris; Stadler, Michael

    2003-09-01

    Deregulation is haltingly changing the United States electricity markets. The resulting uncertainty and/or rising energy costs can be hedged by generating electricity on-site and other benefits, such as use of otherwise wasted heat, can be captured. The Public Utility Regulatory Policy Act (PURPA) of 1978 first invited relatively small-scale generators ({ge} 1 MW) into the electricity market. The advent of efficient and reliable small scale and renewable equipment has spurred an industry that has, in recent years, made even smaller (business scale) electricity generation an economically viable option for some consumers. On-site energy capture and/or conversion, known as distributed energy resources (DER), offers consumers many benefits, such as economic savings and price predictability, improved reliability, control over power quality, and emissions reductions. Despite these benefits, DER adoption can be a daunting move to a customer accustomed to simply paying a monthly utility bill. San Diego is in many ways an attractive location for DER development: It has high electricity prices typical of California and a moderate climate i.e. energy loads are consistent throughout the year. Additionally, the price shock to San Diego Gas and Electric (SDG&E) customers during the summer of 2000 has interested many in alternatives to electricity price vulnerability. This report examines the business case for DER at the San Diego biotechnology supply company, BD Biosciences Pharmingen, which considered DER for a building with 200-300 kW base-load, much of which accommodates the refrigerators required to maintain chemicals. Because of the Mediterranean climate of the San Diego area and the high rate of air changes required due to on-site use of chemicals, modest space heating is required throughout the year. Employees work in the building during normal weekday business hours, and daily peak loads are typically about 500 kW.

  14. SBBN 2010: 7. Congress of the Brazilian Society of Nuclear Biosciences. Radiations in biosciences: advances and trends; SBBN 2010: 7. Congresso da Sociedade Brasileira de Biociencias Nucleares. Radiacoes em biociencias: avancos e perspectivas

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Advance and new perspectives related to the use of ionizing and no ionizing radiations in nuclear biosciences are presented. Multidisciplinary approach, including radiopharmacy, radioprotection and dosimetry, cytogenetic, biosafety, radioecology, environmental toxicology are studied. Topics of Nuclear medicine, radiotherapy and image diagnosis, such as computerized tomography, PET scan, phantoms, biomedical radiography, are reported. Use of radioisotopes, evaluation of radiation dose rates, radiation dose distribution, radiation monitoring is considered. Environmental impact of radiation are also in human beings, animals and for several purposes are analyzed. (MAC)

  15. Anthropocene Age Wicked Challenges

    DEFF Research Database (Denmark)

    Edgeman, Rick; Wu, Zhaohui

    2015-01-01

    Grand global challenges, including wicked human caused or influenced ones key to sustainability, characterize the Anthropocene Age. Among these are climate change driven by increased methane and CO2 in the atmosphere; consequent global warming and increasing intensity and incidence of extreme...

  16. A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

    Directory of Open Access Journals (Sweden)

    Quail Michael A

    2012-07-01

    Full Text Available Abstract Background Next generation sequencing (NGS technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’ RS and the Illumina MiSeq. Here we compare the results obtained with those platforms to the performance of the Illumina HiSeq, the current market leader. In order to compare these platforms, and get sufficient coverage depth to allow meaningful analysis, we have sequenced a set of 4 microbial genomes with mean GC content ranging from 19.3 to 67.7%. Together, these represent a comprehensive range of genome content. Here we report our analysis of that sequence data in terms of coverage distribution, bias, GC distribution, variant detection and accuracy. Results Sequence generated by Ion Torrent, MiSeq and Pacific Biosciences technologies displays near perfect coverage behaviour on GC-rich, neutral and moderately AT-rich genomes, but a profound bias was observed upon sequencing the extremely AT-rich genome of Plasmodium falciparum on the PGM, resulting in no coverage for approximately 30% of the genome. We analysed the ability to call variants from each platform and found that we could call slightly more variants from Ion Torrent data compared to MiSeq data, but at the expense of a higher false positive rate. Variant calling from Pacific Biosciences data was possible but higher coverage depth was required. Context specific errors were observed in both PGM and MiSeq data, but not in that from the Pacific Biosciences platform. Conclusions All three fast turnaround sequencers evaluated here were able to generate usable sequence. However there are key differences between the quality of that data and the applications it will support.

  17. Software Engineering Support of the Third Round of Scientific Grand Challenge Investigations: An Earth Modeling System Software Framework Strawman Design that Integrates Cactus and UCLA/UCB Distributed Data Broker

    Science.gov (United States)

    Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn

    2002-01-01

    One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task. both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation, while maintaining high performance across numerous supercomputer and workstation architectures. This document proposes a strawman framework design for the climate community based on the integration of Cactus, from the relativistic physics community, and UCLA/UCB Distributed Data Broker (DDB) from the climate community. This design is the result of an extensive survey of climate models and frameworks in the climate community as well as frameworks from many other scientific communities. The design addresses fundamental development and runtime needs using Cactus, a framework with interfaces for FORTRAN and C-based languages, and high-performance model communication needs using DDB. This document also specifically explores object-oriented design issues in the context of climate modeling as well as climate modeling issues in terms of object-oriented design.

  18. Bioculture System: Expanding ISS Space Bioscience Capabilities for Fundamental Stem Cell Research and Commercial Applications

    Science.gov (United States)

    Blaber, Elizabeth; Dvorochkin, Natalya; Almeida, Eduardo; Fitzpatrick, Garret; Ellingson, Lance; Mitchell, Sarah; Yang, Anthony; Kosnik, Cristine; Rayl, Nicole; Cannon, Tom; Austin, Edward; Sato, Kevin

    With the recent call by the 2011 Decadal Report and the 2010 Space Biosciences Roadmap for the International Space Station (ISS) to be used as a National Laboratory for scientific research, there is now a need for new laboratory instruments on ISS to enable such research to occur. The Bioculture System supports the extended culturing of multiple cell types and microbiological specimens. It consists of a docking station that carries ten independent incubation units or ‘Cassettes’. Each Cassette contains a cooling chamber (5(°) C) for temperature sensitive solutions and samples, or long duration fluids and sample storage, as well as an incubation chamber (ambient up to 42(°) C). Each Cassette houses an independent fluidics system comprised of a biochamber, medical-grade fluid tubing, medium warming module, oxygenation module, fluid pump, and sixteen solenoid valves for automated biochamber injections of sampling. The Bioculture System provides the user with the ability to select the incubation temperature, fluid flow rate and automated biochamber sampling or injection events for each separate Cassette. Furthermore, the ISS crew can access the biochamber, media bag, and accessory bags on-orbit using the Microgravity Science Glovebox. The Bioculture System also permits initiation of cultures, subculturing, injection of compounds, and removal of samples for on-orbit processing using ISS facilities. The Bioculture System therefore provides a unique opportunity for the study of stem cells and other cell types in space. The first validation flight of the Bioculture System will be conducted on SpaceX5, consisting of 8 Cassettes and lasting for 30-37 days. During this flight we plan to culture two different mammalian cell types in bioreactors: a mouse osteocytic-like cell line, and human induced pluripotent stem cell (iPS)-derived cardiomyocytes. Specifically, the osteocytic line will enable the study of a type of cell that has been flown on the Bioculture System

  19. 78 FR 11678 - Notice of Inventory Completion: Grand Rapids Public Museum, Grand Rapids, MI

    Science.gov (United States)

    2013-02-19

    ... National Park Service Notice of Inventory Completion: Grand Rapids Public Museum, Grand Rapids, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Grand Rapids Public Museum has completed an... Grand Rapids Public Museum. Repatriation of the human remains and associated funerary objects to...

  20. Teaching a Dyslexic Student: A Personal View How Critical Incident Analysis Can Be Used as an Effective Pedagogical Tool in Undergraduate Biosciences

    Science.gov (United States)

    Ahluwalia, Jatinder

    2009-01-01

    This paper examines the concept of critical incident analysis in respect of improving the pedagogical practices in teaching dyslexic undergraduate biosciences students. Critical incident analysis is a well established pedagogical theory (Tripp, 1993) that allows reflection of a seemingly typical incident; the "critical incident", so that changes…

  1. A qualitative study of the relationship of personality type with career management and career choice preference in a group of bioscience postgraduate students and postdoctoral researchers

    OpenAIRE

    Blackford, Sarah

    2010-01-01

    This study reports on the career management and career choice preferences of a sample of bioscience postgraduate students and postdoctoral researchers according to their personality type as determined using the Myers Briggs Type Indicator (MBTI). Correlations can be found but other decision-making processes come into play and are more influential regarding career choices

  2. Results from KASCADE-Grande

    Energy Technology Data Exchange (ETDEWEB)

    Bertaina, M., E-mail: bertaina@to.infn.it [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Apel, W.D. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Arteaga-Velazquez, J.C. [Universidad Michoacana, Instituto de Fisica y Matematicas, Morelia (Mexico); Bekk, K. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bluemer, J. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Bozdog, H. [Institut fuer Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Buchholz, P. [Fachbereich Physik, Universitaet Siegen (Germany); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, KIT - Karlsruher Institut fuer Technologie (Germany); and others

    2012-11-11

    The KASCADE-Grande experiment, located at Karlsruhe Institute of Technology (Germany) is a multi-component extensive air-shower experiment devoted to the study of cosmic rays and their interactions at primary energies 10{sup 14}-10{sup 18} eV. Main goals of the experiment are the measurement of the all-particle energy spectrum and mass composition in the 10{sup 16}-10{sup 18} eV range by sampling charged (N{sub ch}) and muon (N{sub {mu}}) components of the air shower. The method to derive the energy spectrum and its uncertainties, as well as the implications of the obtained result, is discussed. An overview of the analyses performed by KASCADE-Grande to derive the mass composition of the measured high-energy comic rays is presented as well.

  3. Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Charlote Wink

    2007-01-01

    Full Text Available The occurrence of Cryptophlebia carpophagoides Clarke, 1951, (Lepidoptera: Olethreutidae, in fruit of Enterolobium contortisiliquum (Vell. Morong, has bun first registered in the state of Rio Grande do Sul, Brazil. The damaged fruit was collected in the campus of National University of Santa Maria, Santa Maria, from May to June of 2003 and 2004. It was evidenced that the caterpillars damage the fruit of that specie affecting the integrety, the vigor and the germination of the seeds.

  4. Grand Unification and Exotic Fermions

    CERN Document Server

    Feger, Robert P

    2015-01-01

    We exploit the recently developed software package LieART to show that SU(N) grand unified theories with chiral fermions in mixed tensor irreducible representations can lead to standard model chiral fermions without additional light exotic chiral fermions, i.e., only standard model fermions are light in these models. Results are tabulated which may be of use to model builders in the future. An SU(6) toy model is given and model searches are discussed.

  5. The KASCADE-grande experiment

    Energy Technology Data Exchange (ETDEWEB)

    Bluemer, J; Apel, W D; Badea, F; Bekk, K; Bozdog, H; Daumiller, K; Doll, P; Engel, R; Engler, J [Institut fuer Kernphysik, Forschungszentrum Karlsruhe (Germany); Arteaga, J C; Cossavella, F; Souza, V de; Finger, M [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe (Germany); Bertaina, M; Chiavassa, A; Cantoni, E; Di Pierro, F [Dipartimento di Fisica Generale dell' Universita Torino (Italy); Brancus, I M [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Brueggemann, M; Buchholz, P [Fachbereich Physik, Universitaet Siegen (Germany)], E-mail: Johannes.Bluemer@ik.fzk.de (and others)

    2008-07-15

    KASCADE-Grande is an extensive air shower array co-located with the original KASCADE air shower experiment at Forschungszentrum Karlsruhe, Germany. The multi-detector system allows to investigate the energy spectrum, composition, and anisotropies of cosmic rays in the energy range extended up to 10{sup 18} eV. An overview on the performance of the apparatus and first results are presented.

  6. The KASCADE-Grande experiment

    Energy Technology Data Exchange (ETDEWEB)

    Apel, W.D. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Arteaga, J.C. [Karlsruhe Institute of Technology - Campus South, Institut fuer Experimentelle Kernphysik, Karlsruhe (Germany); Badea, A.F.; Bekk, K. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Bertaina, M. [Dipartimento di Fisica Generale dell' Universita Torino (Italy); Bluemer, J. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Karlsruhe Institute of Technology - Campus South, Institut fuer Experimentelle Kernphysik, Karlsruhe (Germany); Bozdog, H. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, Bucharest (Romania); Buchholz, P. [Universitaet Siegen, Fachbereich Physik, Siegen (Germany); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita Torino (Italy); Cossavella, F. [Karlsruhe Institute of Technology - Campus South, Institut fuer Experimentelle Kernphysik, Karlsruhe (Germany); Daumiller, K. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Souza, V. de [Karlsruhe Institute of Technology - Campus South, Institut fuer Experimentelle Kernphysik, Karlsruhe (Germany); Di Pierro, F., E-mail: dipierr@to.infn.i [Dipartimento di Fisica Generale dell' Universita Torino (Italy); Doll, P.; Engel, R.; Engler, J.; Finger, M. [Karlsruhe Institute of Technology - Campus North, Institut fuer Kernphysik, Karlsruhe (Germany); Fuhrmann, D. [Bergische Universitaet Wuppertal, Fachbereich Physik, Wuppertal (Germany)

    2010-08-21

    KASCADE-Grande is the enlargement of the KASCADE extensive air shower detector, realized to expand the cosmic ray studies from the previous 10{sup 14}-10{sup 17} eV primary energy range to 10{sup 18} eV. This is performed by extending the area covered by the KASCADE electromagnetic array from 200x200 to 700x700 m{sup 2} by means of 37 scintillator detector stations of 10 m{sup 2} area each. This new array is named Grande and provides measurements of the all-charged particle component of extensive air showers (N{sub ch}), while the original KASCADE array particularly provides information on the muon content (N{sub {mu}}). Additional dense compact detector set-ups being sensitive to energetic hadrons and muons are used for data consistency checks and calibration purposes. The performance of the Grande array and its integration into the entire experimental complex is discussed. It is demonstrated that the overall observable resolutions are adequate to meet the physical requirements of the measurements, i.e. primary energy spectrum and elemental composition studies in the primary cosmic ray energy range of 10{sup 16}-10{sup 18} eV.

  7. ONR STEM Grand Challenge: Extensible Adaptive System for STEM Learning

    Science.gov (United States)

    2013-04-12

    advanced learning systems. These learning systems employ state-of- the-art pedagogical and computation techniques to improve student proficiency in...used by domain experts and system administrators to add and modify knowledge sources used by the SAT Physics EAITS in an ongoing manner without the...developers, subject matter experts, and system administrators . All such users access the system through one of two end user interfaces, which are both

  8. Grand Challenges in Space Technology: Distributed Satellite Systems

    Science.gov (United States)

    2001-07-01

    modem interests in readability, extensibility and expressiveness. To achieve these goals Embedded C ++ (EC++) has been chosen as the standard for GRRDE...of embedded C ++ as a programming language for FSW. The ongoing simulation of the TechSat21 system will provide an invaluable analysis of this mission...time. The study has also demonstrated the suitability of OSE as a real-time distributed operating system and of embedded C ++ as a programming language

  9. Facing the Grand Challenges through Heuristics and Mindfulness

    Science.gov (United States)

    Powietrzynska, Malgorzata; Tobin, Kenneth; Alexakos, Konstantinos

    2015-01-01

    We address the nature of mindfulness and its salience to education generally and to science education specifically. In a context of the historical embeddedness of mindfulness in Buddhism we discuss research in social neuroscience, presenting evidence for neuronal plasticity of the brain and six emotional styles, which are not biologically…

  10. Science, technology and the 'grand challenge' of aging

    DEFF Research Database (Denmark)

    Jæger, Birgit; Peine, Alexander; Moors, Ellen

    2015-01-01

    In this paper, we introduce the themes addressed and the approaches used in this special issue. We start by briefly discussing the state of the art in research and policy making related to science, technology and ageing. We argue that an important gap characterizes this state of the art: current ...... on the socio-material constitution of later life that implicates an important agenda for the future study of ageing and gerontechnology innovation....

  11. Security and Privacy Grand Challenges for the Internet of Things

    Energy Technology Data Exchange (ETDEWEB)

    Fink, Glenn A.; Zarzhitsky, Dimitri V.; Carroll, Thomas E.; Farquhar, Ethan D.

    2015-08-20

    Abstract— The growth of the Internet of Things (IoT) is driven by market pressures, and while security is being considered, the relationship between the unintended consequences of billions of such devices connecting to the Internet cannot be described with existing mathematical methods. The possibilities for illicit surveillance through lifestyle analysis, unauthorized access to information, and new attack vectors will continue to increase by 2020, when up-to 50 billion devices may be connected. This paper discusses various kinds of vulnerabilities that can be expected to arise, and presents a research agenda for mitigating the worst of the impacts. We hope to draw research attention to the potential dangers of IoT so that many of these problems can be avoided.

  12. Engineering central metabolism - a grand challenge for plant biologists.

    Science.gov (United States)

    Sweetlove, Lee J; Nielsen, Jens; Fernie, Alisdair R

    2016-12-22

    The goal of increasing crop productivity and nutrient-use efficiency is being addressed by a number of ambitious research projects seeking to re-engineer photosynthetic biochemistry. Many of these projects will require the engineering of substantial changes in fluxes of central metabolism. However, as has been amply demonstrated in simpler systems such as microbes, central metabolism is extremely difficult to rationally engineer. This is because of multiple layers of regulation that operate to maintain metabolic steady state and because of the highly connected nature of central metabolism. In this review we discuss new approaches for metabolic engineering that have the potential to address these problems and dramatically improve the success with which we can rationally engineer central metabolism in plants. In particular, we advocate the adoption of an iterative 'design-build-test-learn' cycle using fast-to-transform model plants as test beds. This approach can be realised by coupling new molecular tools to incorporate multiple transgenes in nuclear and plastid genomes with computational modelling to design the engineering strategy and to understand the metabolic phenotype of the engineered organism. We also envisage that mutagenesis could be used to fine-tune the balance between the endogenous metabolic network and the introduced enzymes. Finally, we emphasise the importance of considering the plant as a whole system and not isolated organs: the greatest increase in crop productivity will be achieved if both source and sink metabolism are engineered.

  13. Grand Challenge Portfolio: Driving Innovation in Industrial Energy Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    None

    2011-01-04

    Under the Recovery Act, AMO provided cost-shared funding for early-stage, low-cost, "concept definition studies" of 47 promising innovations for next-generation manufacturing, energy-intensive processes, advanced materials, and greenhouse gas emissions reduction. The brochure provides information on each of these projects.

  14. Graafikatriennaali grand prix Korea kunstnikule

    Index Scriptorium Estoniae

    1998-01-01

    Tallinna XI graafikatriennaali rahvusvaheline žürii andis grand prix korea kunstnikule Chung¡Sang-Gonile, kolm võrdset preemiat - soome kunstnikele Anita Jensenile ja Tapani Mikkonenile ning jaapani kunstnikule Estuko Obatale. Eesti Kunstimuuseumi preemia - Wendy Swallow. Tallinna linna preemia ja Ivar Luki sponsoripreemia - Walter Jule. Sponsoripreemiad : Paletti Eesti AS preemia - Inga Heamägi; Rannila Profiili preemia - Mojca Zlokarnik; UNDP preemia - Andrea Juan. Rotermanni soolalao arhitektuuri- ja kunstikeskuse diplom - Lis Ingram, Heli Päivikki Kurunsaari, Randi Strand, Wendy Swallow

  15. Grand unification: quo vadis domine

    Energy Technology Data Exchange (ETDEWEB)

    Senjanovic, G.

    1985-01-01

    The present theoretical and experimental situation with grand unification is summarized. The issues of proton decay and the Weinberg angle are addressed, going through the predictions of both the standard SU(5) theory and its supersymmetric extension. The SO(10) theory, which provides a minimal one family model, is then studied. The gravitational characteristics of domain walls and strings are then discussed. It is argued that there is a need to go beyond SO(10) in order to incorporate a unified picture of families. This leads to the prediction of mirror fermions, whose physics is analyzed. 31 refs. (LEW)

  16. Grand Gauge-Higgs Unification

    CERN Document Server

    Kojima, Kentaro; Yamashita, Toshifumi

    2011-01-01

    We propose a novel way to break grand unified gauge symmetries via the Hosotani mechanism in models that can accommodate chiral fermions. Adjoint scalar fields are realized through the so-called diagonal embedding method which is often used in the heterotic string theory. We calculate the one-loop effective potential of the adjoint scalar field in a five dimensional model compactified on an S^1/Z_2 orbifold, as an illustration. It turns out that the potential is basically the same as the one in an S^1 model, and thus the results in literatures, in addition to the chiral fermions, can be realized easily.

  17. Grand canonical Molecular Dynamics Simulations

    CERN Document Server

    Fritsch, S; Junghans, C; Ciccotti, G; Site, L Delle; Kremer, K

    2011-01-01

    For simulation studies of (macro-) molecular liquids it would be of significant interest to be able to adjust/increase the level of resolution within one region of space, while allowing for the free exchange of molecules between (open) regions of different resolution/representation. In the present work we generalize the adaptive resolution idea in terms of a generalized Grand Canonical approach. This provides a robust framework for truly open Molecular Dynamics systems. We apply the method to liquid water at ambient conditions.

  18. Grand unified theories from superstrings

    CERN Document Server

    Cleaver, G B

    1996-01-01

    I discuss how traditional grand unified theories, which require adjoint (or higher representation) Higgs fields for breaking to the standard model, can be contained within string theory. The status of stringy free fermionic three generation SO(10) SUSY--GUT models is reviewed. Progress in classification of both SO(10)_2 charged and uncharged embeddings and in N=1 spacetime solutions is discussed. Based on talks presented at the Workshop on SUSY Phenomena and SUSY GUTs, Santa Barbara, California, Dec. 7-11, 1995, and at the Orbis Scientiae, Coral Gables, Florida, January 25-28, 1996. To appear in the Proceedings of Orbis Scientiae, 1996.

  19. American Grand Strategy: The End of Primacy?

    Science.gov (United States)

    2015-02-13

    harbingers of the end of American power or influence, we should note the new context of our international relationships and reassess our grand strategy as...AIR WAR COLLEGE AIR UNIVERSITY AMERICAN GRAND STRATEGY THE END OF PRIMACY? by Carey J. Jones, USAF, Lt Col A Research Report Submitted...Grand Strategy: The End of Primacy 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER

  20. 77 FR 11575 - Notice of Inventory Completion: Grand Rapids Public Museum, Grand Rapids, MI

    Science.gov (United States)

    2012-02-27

    ... National Park Service Notice of Inventory Completion: Grand Rapids Public Museum, Grand Rapids, MI AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Grand Rapids Public Museum has completed an... Rapids Public Museum. Repatriation of the human remains and associated funerary objects to the...

  1. Grandes almacenes en Ginebra, Suiza

    Directory of Open Access Journals (Sweden)

    Braillard, P.

    1968-10-01

    Full Text Available This large building, whose metal structure is one of the most important ones erected in Switzerland, has 14 storeys. The sales zones occupy all the above ground floor levels, and the basements contain garages and stores. Additionally, there is a restaurant on the third floor, and administrative offices in the fourth floor of this outstanding commercial building, the «La Placette» Stores, of Geneva.Este gran edificio, cuya estructura metálica es una de las mayores construidas en Suiza, fue organizado en 14 niveles. Las plantas baja y superiores están destinadas a «venta»; y los sótanos, a garajes, almacenes, etc. La tercera planta alberga, además, el comedor, restaurante, etc.; y la cuarta, los locales de administración y dirección de este notable edificio comercial: «Grandes Almacenes La Placette», de Ginebra.

  2. Proton decay and grand unification

    CERN Document Server

    Senjanovic, Goran

    2009-01-01

    I review the theoretical and experimental status of proton decay theory and experiment. Regarding theory, I focus mostly, but not only, on grand unification. I discuss only the minimal, well established SU(5) and SO(10) models, both ordinary and supersymmetric. I show how the minimal realistic extensions of the original Georgi - Glashow model can lead to interesting LHC physics, and I demonstrate that the minimal supersymmetric SU(5) theory is in perfect accord with experiment. Since no universally accepted model has of yet emerged, I discuss the effective operator analysis of proton decay and some related predictions from a high scale underlying theory. A strong case is made for the improvement of experimental limits, or better the search of, two body neutron decay modes into charged kaons and charged leptons. Their discovery would necessarily imply a low energy physics since they practically vanish in any theory with a desert in energies between M_W and M_GUT.

  3. The Promise and Pitfalls of Grand Strategy

    Science.gov (United States)

    2012-08-01

    clarify the analysis that follows.3 There is no single, universally accepted definition of grand strategy. The British military historian Sir Basil ...presidential campaign—that American policy had come loose from its democratic moorings . When it comes to grand strategy, working within the strictures

  4. 33 CFR 117.285 - Grand Canal.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Grand Canal. 117.285 Section 117.285 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Florida § 117.285 Grand Canal. (a) The draw of the Lansing Island bridge, mile 0.7, shall open on...

  5. Proton hexality in local grand unification

    Energy Technology Data Exchange (ETDEWEB)

    Foerste, Stefan; Nilles, Hans Peter [Bonn Univ. (Germany). Bethe Center for Theoretical Physics and Physikalisches Institut; Ramos-Sanchez, Saul [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Vaudrevange, Patrick K.S. [Muenchen Univ. (Germany). Arnold Sommerfeld Center for Theoretical Physics

    2010-07-15

    Proton hexality is a discrete symmetry that avoids the problem of too fast proton decay in the supersymmetric extension of the standard model. Unfortunately it is inconsistent with conventional grand unification. We show that proton hexality can be incorporated in the scheme of ''Local Grand Unification'' discussed in the framework of model building in (heterotic) string theory. (orig.)

  6. Grand Unification, Higgs Bosons, and Baryogenesis

    Science.gov (United States)

    Sher, Marc

    2004-03-01

    My task in these lectures is to discuss "Grand Unification and Higgs Bosons". Given that each of these subjects has had books written about them, this is a daunting task. My goal will be to introduce the basics of each topic, and provide references for those who wish to explore the topics further. I'll begin with a general motivation for grand unification, followed with an elementary review of SU(N) group algebra. The seminal SU(5) model will be discussed, followed by the supersymmetric version. On the second day, we'll look at other grand unified theories, and then look at the various methods of supersymmetry breaking in the context of grand unification. The third day, we'll turn to the Higgs mechanism, the effective potential, and mass bounds in the Standard Model and the MSSM. Finally, we'll look at baryogenesis, first in grand unified theories and then in the electroweak model.

  7. La Grande: volver a empezar

    Directory of Open Access Journals (Sweden)

    Julio Premat

    2011-07-01

    Full Text Available Este texto, borrador de un trabajo más amplio, pretende despejar algunas pistas de lectura de La grande, en tanto que paradójico final de la producción de Saer. Digo “paradójico” porque puede tomársela como una novela de comienzo o de origen : de un volver a empezar, en todos los sentidos del término. En esa perspectiva podrían estudiarse algunos núcleos temáticos (como el retorno o el recuerdo de cara a la construcción del texto, a la relación planteada con la tradición y a la singular historia de su escritura (y al material genético que rodea y completa esta novela a la vez inacabada y póstuma. En esta intervención, la idea es la de comentar tres textos, escenas o frases del texto, y a partir de allí esbozar pistas para un estudio que está en ciernes.Première ébauche d’un travail de plus d’ampleur, ce texte vise à éclairer quelques pistes de lecture de La grande, en tant que fin paradoxale de la production de Saer. Je dis « paradoxale » parce que l’on peut considérer cette œuvre comme un roman des commencements ou des origines : comme un retour aux débuts, dans tous les sens du terme. Dans cette perspective, plusieurs nœuds thématiques (comme le retour ou le souvenir pourraient être étudiés en relation à la construction du texte, à la relation qui s’établit avec la tradition et à la singulière histoire de son écriture (et au matériau génétique qui entoure et complète ce roman, à la fois inachevé et posthume. Il sera question ici de commenter trois textes, scènes ou phrases du texte, et d’ébaucher à partir de là quelques pistes pour une étude à l’état naissant.The objective of this text, a draft for a broader work, is to outline some reading clues for La grande, inasmuch as it constitutes a paradoxical ending of Saer’s production. I say “paradoxical” because we can consider this work a novel of beginnings or of origins: a return to the beginning, in every meaning of the

  8. Programmable bio-nano-chip system: a flexible point-of-care platform for bioscience and clinical measurements.

    Science.gov (United States)

    McRae, Michael P; Simmons, Glennon W; Wong, Jorge; Shadfan, Basil; Gopalkrishnan, Sanjiv; Christodoulides, Nicolaos; McDevitt, John T

    2015-10-21

    The development of integrated instrumentation for universal bioassay systems serves as a key goal for the lab-on-a-chip community. The programmable bio-nano-chip (p-BNC) system is a versatile multiplexed and multiclass chemical- and bio-sensing system for bioscience and clinical measurements. The system is comprised of two main components, a disposable cartridge and a portable analyzer. The customizable single-use plastic cartridges, which now can be manufactured in high volumes using injection molding, are designed for analytical performance, ease of use, reproducibility, and low cost. These labcard devices implement high surface area nano-structured biomarker capture elements that enable high performance signaling and are index-matched to real-world biological specimens. This detection modality, along with the convenience of on-chip fluid storage in blisters and self-contained waste, represents a standard process to digitize biological signatures at the point-of-care. A companion portable analyzer prototype has been developed to integrate fluid motivation, optical detection, and automated data analysis, and it serves as the human interface for complete assay automation. In this report, we provide a systems-level perspective of the p-BNC universal biosensing platform with an emphasis on flow control, device integration, and automation. To demonstrate the flexibility of the p-BNC, we distinguish diseased and non-case patients across three significant disease applications: prostate cancer, ovarian cancer, and acute myocardial infarction. Progress towards developing a rapid 7 minute myoglobin assay is presented using the fully automated p-BNC system.

  9. Militari italiani e grande guerra

    Directory of Open Access Journals (Sweden)

    Emilio Franzina

    2015-01-01

    Full Text Available Il saggio verte su alcuni aspetti dei fenomeni immigratori che si collegano alla genesi e alla tenuta dei sensi di appartenenza etnica e nazionale. Accanto alla progressiva rimozione dei vecchi meccanismi di acculturazione linguistica, che scalzano, ove posseduto in partenza, l’italiano procurando la sua sostituzione progressiva –e in parte fisiologica– con il castigliano si assiste in America, per integrazione, anche al declino dell’“italianità politica”. Un momento di svolta prima del definitivo affermarsi di tale processo di “argentinizzazione” fu rappresentato però dalla congiuntura della grande guerra. Il suo deflagrare, infatti, coincise con il momento di massima espansione (non solo a Buenos Aires della presenza immigratoria straniera e di quella italiana in particolare. Diversamente da quanto succederà più tardi con il secondo conflitto mondiale, dopo quasi vent’anni però di declino o di arresto dei flussi in entrata, tra il 1914 e il 1918 si poté assistere infatti a una concreta forma di doppio patriottismo o di duplice lealtà politico-istituzionale da parte dei gruppi etnici immigratori all’interno dei quali si generarono scelte come la decisione presa da molti dei loro componenti di arruolarsi sotto le bandiere delle “antiche patrie” per raggiungere i campi di battaglia europei.

  10. Rio Grande Channel, Guadalupe Area, 1852

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Historical map of Rio Grande river between Texas and Mexico. U.S.- Mexican Boundary Survey. The original map is a xerox of a map entitled Boundary between the United...

  11. Rio Grande Channel, El Paso Area, 1852

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — Historical map of Rio Grande river between Texas and Mexico. U.S.-Mexican Boundary Survey.The original map is a Xerox of a Photolithographic Copy of Salazar...

  12. 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.

    Science.gov (United States)

    Nelson, Christopher J; Ausió, Juan

    2012-06-01

    The 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability in Whistler, Canada, 14-18 March 2012, brought together 31 speakers from different nationalities. The organizing committee, led by Jim Davie (Chair) at the University of Manitoba (Manitoba, Canada), consisted of several established researchers in the fields of chromatin and epigenetics from across Canada. The meeting was centered on the contribution of epigenetics to gene expression, DNA damage and repair, and the role of environmental factors. A few interesting talks on replication added some insightful information on the controversial issue of histone post-translational modifications as genuine epigenetic marks that are inherited through cell division.

  13. Tutorials in mathematical biosciences

    CERN Document Server

    2008-01-01

    The book offers an easy introduction to fast growing research areas in evolution of species, population genetics, ecological models, and population dynamics. The first two chapters review the concept and methodologies of phylogenetic trees; computational schemes and illustrations are given, including applications such as tracing the origin of SARS and influenza. The third chapter introduces the reader to ecological models, including predator-prey models. This chapter includes and introduction to reaction-diffusion equations, which are used to analyze the ecological models. The next chapter reviews a broad range of ongoing research in population dynamics, including evolution of dispersal models; it also features interesting mathematical theorems and lists open problems. The final chapter deals with gene frequencies under the action of migration and selection. The book is addressed to readers at the level of grad students and researchers. A background in PDEs is provided.

  14. Grand Forks - East Grand Forks Urban Water Resources Study. Flood Control Appendix.

    Science.gov (United States)

    1981-07-01

    will serve as effective partial " tools " for comprehensive floodplain management at Grand Forks. Emergency flood barriers at Grand Forks would reduce...115 205 (1) See figure 4. (2) Outside study area; not to be devoped . Table 2 - Estimated peak runoff 10-year frequency Peak flow Existing Future

  15. Las cinco grandes dimensiones de la personalidad

    OpenAIRE

    Jan ter Laak

    1996-01-01

    Este artículo revisa las distintas posiciones teóricas sobre las cinco grandes dimensiones de la personalidad, mostrando las semejanzas y diferencias entre las posturas teóricas. Esta contribución presenta lo siguiente: (a) la génesis del contenido y la estructura de las cinco dimensiones; (b) la fortaleza de las cinco dimensiones; (e) la relación de las cinco grandes dimensiones con otros constructos de personalidad; (d) discute el valor predictivo de las puntuaciones del perfil de las cinco...

  16. A Grand Delta(96) x SU(5) Flavour Model

    CERN Document Server

    King, Stephen F; Stuart, Alexander J

    2012-01-01

    Recent results from the Daya Bay and RENO reactor experiments have measured the smallest lepton mixing angle and found it to have a value of theta_13 approximately 9 degrees. This result presents a new challenge for the existing paradigms of discrete flavour symmetries which attempt to describe all quark and lepton masses and mixing angles. Here we propose a Supersymmetric Grand Unified Theory of Flavour based on Delta(96) x SU(5), together with a U(1) x Z3 symmetry, including a full discussion of Delta(96) in a convenient basis. The Grand Delta(96) x SU(5) Flavour Model relates the quark mixing angles and masses in the form of the Gatto-Sartori-Tonin relation and realises the Georgi-Jarlskog mass relations between the charged leptons and down-type quarks. We predict a Bi-trimaximal (not Tri-bimaximal) form of neutrino mixing matrix, which, after including charged lepton corrections with zero phase, leads to the following GUT scale predictions for the atmospheric, solar, and reactor mixing angles: theta_23=36...

  17. Applying Systems Engineering on Energy Challenges

    NARCIS (Netherlands)

    Safi, J.; Muller, G.; Bonnema, G.M.

    2012-01-01

    Systems engineering is a discipline with methods and techniques to address complex problems. We want to study how Systems Engineering methods can help to address today's grand challenges, such as the energy problem. The first step is problem definition which aims at articulating the problem in its c

  18. Meeting the Energy-Climate Challenge

    Science.gov (United States)

    2010-04-21

    White House Office of Science and Technology Policy Lectur Remarks at the NAE Grand Challenges Summit Chicago • 21...more frequent because of l b l h ti ill b “ l” i id i b 2050g o a ea ng, w e norma n m -range scenar o y Black lines are observed temps

  19. Radiatively Induced Fermi Scale in Grand Unification

    DEFF Research Database (Denmark)

    Alanne, Tommi; Meroni, Aurora; Sannino, Francesco;

    2016-01-01

    We consider Grand Unified Theories in which the hierarchy between the unification and the Fermi scale emerges radiatively. Within the Pati-Salam framework, we show that it is possible to construct a viable model where the Higgs is an elementary pseudo-Goldstone boson, and the correct hierarchy...

  20. Rio Branco, grand strategy and naval power

    Directory of Open Access Journals (Sweden)

    João Paulo Alsina Jr.

    2014-12-01

    Full Text Available This article addresses Baron of Rio Branco's grand strategy and the role played by the naval reorganization program (1904-1910 in this context. The ensuing case study determined the domestic and international constraints that affected the program, as well as the worldview of the patron of Brazilian diplomacy regarding military power's instrumentality to foreign policy.

  1. Reisipakkumine - Grand Tour Itaalias / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2009-01-01

    Tiina Abeli koostatud ja Urmas Viigi kujundatud näitus "Grand Tour. Eesti kunstnikud Itaalias" Kumu Kunstimuuseumis 05. aprillini. Loetletud eksponeeritud tööde autoreid. Näitus annab ülevaate, kes siinsetest kunstnikest 19. sajandi algusest kuni 1930ndate aastateni Itaalias käisid ja kuidas see nende loomingut mõjutas

  2. Grand Canyon Humpback Chub Population Improving

    Science.gov (United States)

    Andersen, Matthew E.

    2007-01-01

    The humpback chub (Gila cypha) is a long-lived, freshwater fish found only in the Colorado River Basin. Physical adaptations-large adult body size, large predorsal hump, and small eyes-appear to have helped humpback chub evolve in the historically turbulent Colorado River. A variety of factors, including habitat alterations and the introduction of nonnative fishes, likely prompted the decline of native Colorado River fishes. Declining numbers propelled the humpback chub onto the Federal list of endangered species in 1967, and the species is today protected under the Endangered Species Act of 1973. Only six populations of humpback chub are currently known to exist, five in the Colorado River Basin above Lees Ferry, Ariz., and one in Grand Canyon, Ariz. The U.S. Geological Survey's Grand Canyon Monitoring and Research Center oversees monitoring and research activities for the Grand Canyon population under the auspices of the Glen Canyon Dam Adaptive Management Program (GCDAMP). Analysis of data collected through 2006 suggests that the number of adult (age 4+ years) humpback chub in Grand Canyon increased to approximately 6,000 fish in 2006, following an approximate 40-50 percent decline between 1989 and 2001. Increasing numbers of adult fish appear to be the result of steadily increasing numbers of juvenile fish reaching adulthood beginning in the mid- to late-1990s and continuing through at least 2002.

  3. Summer Grand Summons Ceremony in Tashilhungpo Monastery

    Institute of Scientific and Technical Information of China (English)

    XILHU

    2003-01-01

    Every year, Tashilhungpo Monastery celebrates the Summer Grand Summons Ceremony (called Ximoqenbo in Tibetan) in the eighth month of the Tibetan calendar. All the monks and lay people of the Xigaze area get together to watch Chammo, which is a kind of sorcerer's dance. It is also a Tantric ritual

  4. Substance Abuse in the Rio Grande Valley.

    Science.gov (United States)

    Zavaleta, Anthony N.

    1979-01-01

    In the Mexican American barrios of Texas' Lower Rio Grande Valley, existence is complicated by the interactive forces of culture, society, and economy. These three factors act in unison to create an etiology of alcohol and drug use and abuse which is poorly understood by persons outside the barrio's grasp. (Author/NQ)

  5. The Virtual Grand Tour as Educational Paradigm

    DEFF Research Database (Denmark)

    Hansen, Per Skafte; Mouritsen, Lars

    2001-01-01

    The Virtual Grand Tour as defined here bears some resemblance to its 18th century ancestor: a wide range of individual topics are treated as a whole; a tutor, whether real or simulated, present or remote, is provided; a set of problem solving tools forms an integrated part of the "traveller...

  6. A Grand Unified Theory of Interdisciplinarity

    Science.gov (United States)

    Davis, Lennard J.

    2007-01-01

    Aside from the appeal to administrators as a tool to reduce costs by combining less robust departments with heftier relations, interdisciplinarity is a powerful idea because it implies that different branches of knowledge can benefit from talking to one another: a grand, unified theory of knowledge in which each discipline contributes building…

  7. Youth Voice and the Llano Grande Center

    Science.gov (United States)

    Guajardo, Francisco; Perez, Delia; Guajardo, Miguel A.; Davila, Eric; Ozuna, Juan; Saenz, Maribel; Casaperalta, Nadia

    2006-01-01

    The Llano Grande Center is a non-profit education and community development organization founded in the mid-1990s by youth and teachers out of a public high school classroom in a rural South Texas (USA) community. The Center was created, in large part, to cultivate youth voices as important elements of curriculum development and teacher training…

  8. "Teine" võitis Prantsusmaal Grand Prix'

    Index Scriptorium Estoniae

    2006-01-01

    Prantsusmaal Essonne'is toimuval 8. Euroopa filmifestivalil Cinessonne sai üliõpilaste žürii grand prix rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre. Ka teistest festivalidest, kus film osalenud

  9. Development of a dedicated beam forming system for material and bioscience research with high intensity, small field electron beam of LILLYPUT 3 accelerator at Wroclaw Technology Park

    CERN Document Server

    Adrich, Przemysław; Wilk, Piotr; Chorowski, Maciej; Poliński, Jarosław; Bogdan, Piotr

    2016-01-01

    The primary use of the LILLYPUT 3 accelerator at the Nondestructive Testing Laboratory at Wroclaw Technology Park is X-ray radiography for nondestructive testing, including R&D of novel techniques for industrial and medical imaging. The scope of possible applications could be greatly extended by providing a system for irradiation with electron beam. The purpose of this work was to design such a system, especially for high dose rate, small field irradiations under cryogenic conditions for material and bioscience research. In this work, two possible solutions, based either on beam scanning or scattering and collimation, were studied and compared. It was found that under existing conditions efficiency of both systems would be comparable. The latter one was adopted due to its simplicity and much lower cost. The system design was optimized by means of detailed Monte Carlo modeling. The system is being currently fabricated at National Centre for Nuclear Research in \\'Swierk.

  10. Liberating methodological thinking in human sciences from grand theories

    DEFF Research Database (Denmark)

    Kharlamov, Nikita; Baldursson, Einar Baldvin

    2016-01-01

    focus on the necessity of a “grand unified theory” at the expense of any and all alternative perspectives. Properties of grand theories are discussed on the examples of Giddens and Bourdieu. It is argued that grand theories hamper a more productive focus on concrete phenomena. Robert Merton’s focus...

  11. 78 FR 39998 - Safety Zone; Grand Haven 4th of July Fireworks; Grand River; Grand Haven, MI

    Science.gov (United States)

    2013-07-03

    ... , type the docket number in the ``SEARCH'' box and click ``SEARCH.'' Click on Open Docket Folder on the... arc of a circle with an 800 foot radius with a center in position 43 3' 55.7'' N and 86 14' 13.8'' W...) Location. All waters of the Grand River within the arc of a circle with an 800 foot radius with a center...

  12. Advantages of Computer Simulation in Enhancing Students' Learning about Landform Evolution: A Case Study Using the Grand Canyon

    Science.gov (United States)

    Luo, Wei; Pelletier, Jon; Duffin, Kirk; Ormand, Carol; Hung, Wei-chen; Shernoff, David J.; Zhai, Xiaoming; Iverson, Ellen; Whalley, Kyle; Gallaher, Courtney; Furness, Walter

    2016-01-01

    The long geological time needed for landform development and evolution poses a challenge for understanding and appreciating the processes involved. The Web-based Interactive Landform Simulation Model--Grand Canyon (WILSIM-GC, http://serc.carleton.edu/landform/) is an educational tool designed to help students better understand such processes,…

  13. Status of the KASCADE-Grande experiment

    Energy Technology Data Exchange (ETDEWEB)

    Ulrich, H. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany)], E-mail: ulrich@ik.fzk.de; Apel, W.D.; Arteaga, J.C.; Badea, A.F.; Bekk, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Bercuci, A. [National Institute of Physics and Nuclear Engineering, P.O. Box Mg-6, RO-7690 Bucharest (Romania); Bertaina, M. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Bluemer, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Bozdog, H. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, P.O. Box Mg-6, RO-7690 Bucharest (Romania); Brueggemann, M.; Buchholz, P. [Fachbereich Physik, Universitaet Siegen, 57068 Siegen (Germany); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Daumiller, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Di Pierro, F. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Doll, P.; Engel, R.; Engler, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Finger, M. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany)] (and others)

    2008-01-15

    The KASCADE-Grande experiment measures extensive air showers induced by cosmic rays in the energy range between 0.5 PeV and 1 EeV - the so-called knee region. Principal task of the experiment is to measure with high accuracy the energy and composition of primary cosmic rays to shed light on the nature of the knee. The data of the former KASCADE experiment have been used in a composition analysis showing the knee at 3-5 PeV to be caused by a steepening in the light-element spectra. In the following, an update on these analyses will be given. In addition, the status of the experimental extension - the Grande array - together with first results will be briefly discussed.

  14. The Grand Tack model: a critical review

    CERN Document Server

    Raymond, Sean N

    2014-01-01

    The `Grand Tack' model proposes that the inner Solar System was sculpted by the giant planets' orbital migration in the gaseous protoplanetary disk. Jupiter first migrated inward then Jupiter and Saturn migrated back outward together. If Jupiter's turnaround or "tack" point was at ~1.5 AU the inner disk of terrestrial building blocks would have been truncated at ~1 AU, naturally producing the terrestrial planets' masses and spacing. During the gas giants' migration the asteroid belt is severely depleted but repopulated by distinct planetesimal reservoirs that can be associated with the present-day S and C types. The giant planets' orbits are consistent with the later evolution of the outer Solar System. Here we confront common criticisms of the Grand Tack model. We show that some uncertainties remain regarding the Tack mechanism itself; the most critical unknown is the timing and rate of gas accretion onto Saturn and Jupiter. Current isotopic and compositional measurements of Solar System bodies -- including ...

  15. Kocel Steel Foundry Grand Opening Ceremony

    Institute of Scientific and Technical Information of China (English)

    TIAN Shi-jiang

    2006-01-01

    @@ On May 9, 2006 the Grand Opening ceremony of Kocel Steel Foundry Co., Ltd. was held in the National Economic and Technological Development Zone in Yinchuan City, Ningxia, China. Kocel Steel Foundry Co.,Ltd. is a large scale enterprise producing steel castings and it is jointly established by Ningxia Kocel Group,Changcheng Suzaki Machine & Foundry Co., Ltd. and Voestalpine Giesserei Linz GmbH, Austria.

  16. Splendid Culture on the Grand Canal

    Institute of Scientific and Technical Information of China (English)

    1993-01-01

    JINING Prefecture on thesouthwest plain of ShandongProvince is known as the homeof Confucius and Mencins and theland of etiquette.It is famous as thebirthplace or residence of many out-standing people and has beautifulscenery with blue Weishan Lake tothe south,lofty Mount Tai to thenorth and Liang Mountain by thelake in the west.The Beijing-Hangzhor Grand Canal crosses theprefecture,which has been a com-munications hub between north andsouth China since the Ming

  17. The Air Force and Grand Strategy

    Science.gov (United States)

    2013-05-01

    Woodrow Wilson The Treaty of Versailles and the Great Depression Following World War I and leading up to the start of World War II, two major...power, manifested in its rejection of the Treaty of Versailles , and the collapse of the global economy in 1929. The Versailles Peace Treaty The...refusal of the US Congress to ratify the 1919 Versailles Peace Treaty played a significant role in molding American grand strategy during the inter

  18. Raptor Use of the Rio Grande Gorge

    Energy Technology Data Exchange (ETDEWEB)

    Ponton, David A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-03-20

    The Rio Grande Gorge is a 115 km long river canyon located in Southern Colorado (15 km) and Northern New Mexico (100 km). The majority of the canyon is under the administration of the Bureau of Land Management {BLM), and 77 km of the canyon south of the Colorado/New Mexico border are designated Wild River under the National Wild and Scenic Rivers Act of 1968. Visits I have made to the Rio Grande Gorge over the past 15 .years disclosed some raptor utilization. As the Snake River Birds of Prey Natural Area gained publicity, its similarity to the Rio Grande Gorge became obvious, and I was intrigued by the possibility of a high raptor nesting density in the Gorge. A survey in 1979 of 20 km of the northern end of the canyon revealed a moderately high density of red-tailed hawks and prairie falcons. With the encouragement of that partial survey, and a need to assess the impact of river-running on nesting birds of prey, I made a more comprehensive survey in 1980. The results of my surveys, along with those of a 1978 helicopter survey by the BLM, are presented in this report, as well as general characterization of the area, winter use by raptors, and an assessment of factors influencing the raptor population.

  19. Gravity as a Grand Unification of Forces

    CERN Document Server

    Sharafiddinov, R S

    2004-01-01

    Any of all possible types of charges corresponds in nature to a kind of the inertial mass. Such a mass - charge duality of matter explains the coexistence of grand united rest mass and charge for the same neutrino equal respectively to its all the gravitational mass and charge which consist of the gravitoelectric, gravitoweak, gravitostrong and a range of others, innate components. From their point of view, a new grand unification theory has been created at the discussion of a question about unification of forces of a different nature. In this theory, the gravitational field must be naturally united gauge field of the unified system of the most diverse combinations of electromagnetic photons, weak bosons and strong gluons where the four pairs of forces of the micro world fundamental interactions are united. Some consequences and laboratory confirmations of the suggested theory have been listed which allow also to define the structure of the graviton as a grand united boson. Thereby it gives the possibility to...

  20. Needs assessment for the Greenway Grand Forks-East Grand Forks development and public education

    Science.gov (United States)

    Munski, Laura

    Following the flood of 1997, the U.S. Army Corps of Engineers included the Greenway Grand Forks---East Grand Forks (the Greenway) as a flood control measure for Grand Forks, North Dakota and East Grand Forks, Minnesota. It extends along both the Red River of the North and the Red Lake River, encompassing 2200 acres of land. The cities of Grand Forks and East Grand Forks hired consultants to assist with the postflood planning process. The planning process culminated with the Red River of the North Greenway Final Report (Flink, 1998). The purpose of this study was to determine if the development of the Greenway addressed the objectives of the planning report. The history of the land adjacent to the rivers was reviewed to document the progression of riverfront development. Anecdotal evidence was collected, field observations were made, city council minutes were reviewed, Greenway Technical Committee members were interviewed, Greenway Technical Committee minutes were reviewed, and the Greenway Grand Forks---East Grand Forks survey results were reviewed to determine if the objectives of the Red River of the North Greenway Final Report were addressed. A cross section survey was designed by Laura Munski for this dissertation research. The survey was approved by the Greenway Technical Committee. The survey collected both quantitative and qualitative data from the community. The purpose of the survey portion of the research project was to ascertain how residents were kept informed of activities on the Greenway and what amenities residents were using on the Greenway and to solicit their comments regarding the Greenway. The results of the survey research were used in both marketing and event planning for the Greenway. The singular qualitative survey question gave respondents an opportunity to share their comments regarding the Greenway. The qualitative data analysis provided insight to the amenities and educational programs desired by respondents, their concerns regarding the

  1. Influence of ankle injury on muscle activation and postural control during ballet grand plié.

    Science.gov (United States)

    Lin, Chia-Wei; Su, Fong-Chin; Lin, Cheng-Feng

    2014-02-01

    Ballet deep squat with legs rotated externally (grand plié) is a fundamental movement for dancers. However, performing this task is a challenge to ankle control, particularly for those with ankle injury. Thus, the purpose of this study was to investigate how ankle sprains affect the ability of postural and muscular control during grand plié in ballet dancers. Thirteen injured dancers and 20 uninjured dancers performed a 15 second grand plié consisting of lowering, squatting, and rising phases. The lower extremity motion patterns and muscle activities, pelvic orientation, and center of pressure (COP) excursion were measured. In addition, a principal component analysis was applied to analyze waveforms of muscle activity in bilateral medial gastrocnemius, peroneus longus, and tibialis anterior. Our findings showed that the injured dancers had smaller pelvic motions and COP excursions, greater maximum angles of knee flexion and ankle dorsiflexion as well as different temporal activation patterns of the medial gastrocnemius and tibialis anterior. These findings suggested that the injured dancers coped with postural challenges by changing lower extremity motions and temporal muscle activation patterns.

  2. Wicked Challenges in the Anthropocene Age: Supply Chain Implications of Sustainable Enterprise Excellence

    DEFF Research Database (Denmark)

    Edgeman, Rick; Wu, Zhaohui

    Grand global challenges include wicked sustainability ones associated with human influences. Among these are climate change in relation to increased atmospheric presence of CO2 and methane, global warming and increasing intensity and incidence rates of extreme weather events, drought...

  3. La "misteriosa" scrittura grande: paleografia e storia

    OpenAIRE

    Modesti, Maddalena; Iannacci, Lorenza; Zuffrano, Annafelicia

    2010-01-01

    Nel 1952 Jan Olof Tjäder riusciva finalmente a decifrare la cosiddetta misteriosa scrittura grande che caratterizza la prima riga di quattro papiri ravennati contenenti protocolli dei gesta municipalia (504-625 d. C.) e a individuarne la base grafica nella corsiva romana antica. Questo permetteva quindi al Tjäder di dimostrare che l’antica scrittura comune romana non era sopravvissuta, dopo il IV secolo, solo nelle litterae caelestes riservate ai documenti imperiali (cfr. Th.9.19.3, 367 d. C....

  4. Grand Banquet of CDM for Power Enterprises

    Institute of Scientific and Technical Information of China (English)

    Peng Yuanchang; Jin Wen

    2007-01-01

    @@ The Kyoto Protocol was taken into effect on Feb. 16, 2005. It requires developed countries to reduce their greenhouse gas emissions, but it doesn't set binding limits on developing countries, such as China. The developed countries found that it is more cost-effective to reduce the emissions in developing countries than in their own. Therefore, the CDM emerged as the times require. Due to unfamiliarity and complicatedness, Chinese enterprises had been hesitating and taking wait-and-see attitude toward CDM, but they couldn't resist the attraction of free dinner of CDM, more and more enterprises started to attend the grand banquet of CDM since 2006.

  5. Inflationary Reheating in Grand Unified Theories

    CERN Document Server

    Bassett, B A; Bassett, Bruce A.; Tamburini, Fabrizio

    1998-01-01

    Grand unified theories may display multiply interacting fields with strong coupling dynamics. This poses two new problems: (1) What is the nature of chaotic reheating after inflation, and (2) How is reheating sensitive to the mass spectrum of these theories ? We answer these questions in two interesting limiting cases and demonstrate an increased efficiency of reheating which strongly enhances non-thermal topological defect formation, including monopoles and domain walls. Nevertheless, the large fluctuations may resolve this monopole problem via a modified Dvali-Liu-Vachaspati mechanism in which non-thermal destabilsation of discrete symmetries occurs at reheating.

  6. The periodicity of Grand Solar Minimum

    Science.gov (United States)

    Velasco Herrera, Victor Manuel

    2016-07-01

    The sunspot number is the most used index to quantify the solar activity. Nevertheless, the sunspot is a syn- thetic index and not a physical index. Therefore, we should be careful to use the sunspot number to quantify the low (high) solar activity. One of the major problems of using sunspot to quantify solar activity is that its minimum value is zero. This zero value hinders the reconstruction of the solar cycle during the Maunder minimum. All solar indexes can be used as analog signals, which can be easily converted into digital signals. In con- trast, the conversion of a digital signal into an analog signal is not in general a simple task. The sunspot number during the Maunder minimum can be studied as a digital signal of the solar activity In 1894, Maunder published a discovery that has maintained the Solar Physics in an impasse. In his fa- mous work on "A Prolonged Sunspot Minimum" Maunder wrote: "The sequence of maximum and minimum has, in fact, been unfailing during the present century [..] and yet there [..], the ordinary solar cycle was once interrupted, and one long period of almost unbroken quiescence prevailed". The search of new historical Grand solar minima has been one of the most important questions in Solar Physics. However, the possibility of estimating a new Grand solar minimum is even more valuable. Since solar activity is the result of electromagnetic processes; we propose to employ the power to quantify solar activity: this is a fundamental physics concept in electrodynamics. Total Solar Irradiance is the primary energy source of the Earth's climate system and therefore its variations can contribute to natural climate change. In this work, we propose to consider the fluctuations in the power of the Total Solar Irradiance as a physical measure of the energy released by the solar dynamo, which contributes to understanding the nature of "profound solar magnetic field in calm". Using a new reconstruction of the Total Solar Irradiance we found the

  7. FOCAL Grande Utopia EM音箱

    Institute of Scientific and Technical Information of China (English)

    成师

    2008-01-01

    对于一个真正在音响领域有所追求的品牌来讲,创新与改进是没有尽头的。尽管愈往前发展,技术的突破度会越来越小,但这仍不妨碍品牌向着高境界的持续前行。近期,法国劲浪(FOCAL)最新发表的Grande Utopia EM音箱,便是展示其研发成果的生动例证。

  8. [Positivism and medical science in Rio Grande do Sul: the Faculdade de Medicina de Porto Alegre].

    Science.gov (United States)

    Weber, B T

    1998-01-01

    The article analyzes conflicts and interests at one of Rio Grande de Sul's main centers for medical science, the Faculdade de Medicina de Porto Alegre. It explores the meaning and impact of the emergence of this specific, exclusive field of knowledge in a state where positivist principles of professional freedom were adopted by successive administrations during the early period of the Republic. Physicians there launched an entrenched war to uphold the principles of science over faith and politics, challenging the positivism of the party which held power in Rio Grande do Sul throughout the years. This perspective grew and developed in a climate of conflict and doubts among physicians, within a political context that differed from the rest of Brazil.

  9. SUGRA Grand Unification, LHC and Dark Matter

    CERN Document Server

    Nath, Pran

    2012-01-01

    A brief review is given of recent developments related to the Higgs signal and its implications for supersymmetry in the supergravity grand unification framework. The Higgs data indicates that the allowed parameter space largely lies on focal curves and focal surfaces of the Hyperbolic Branch of radiative breaking of the electroweak symmetry where TeV size scalars naturally arise. The high mass of the Higgs leads to a more precise prediction for the allowed range of the spin independent neutralino -proton cross section which is encouraging for the detection of dark matter in future experiments with greater sensitivity. Also discussed is the status of grand unification and a natural solution to breaking the GUT group at one scale and resolving the doublet-triplet problem. It is shown that the cosmic coincidence can be compatible within a supersymmetric framework in a muticomponent dark matter picture with one component charged under $B-L$ while the other component is the conventional supersymmetric dark matter...

  10. Graviton as a Grand United Gauge Boson

    Science.gov (United States)

    Sharafiddinov, Rasulkhozha S.

    2015-04-01

    To any type of charge corresponds a kind of inertial mass. Such a mass-charge duality explains the availability in the neutrino of the naturally united rest mass and charge equal to all its mass and charge consisting of the electric, weak, strong and a range of other the innate components. From their point of view, we discuss a new theory of a grand unification. In this theory, the gravitational field is a naturally united field of the unified system of the most diverse combinations of the electric photons, magnetic monophotons, weak bosons and the strong gluons where the four pairs of forces of a different nature are united. Some consequences and laboratory confirmations of the discussed theory have been listed, in which graviton is predicted as a grand united gauge boson. Therefore, the gravitons constitute a natural light testifying in favor of gravitational force. They show that to each type of light corresponds a kind of force. Thereby, the suggested field theory that unites all gauge bosons in gravitons gives the possibility to directly look on the nature of gravitational matter elucidating the interratio of intragraviton forces and the problem of elementary particle fundamental symmetries.

  11. Aspects Of Grand Unified And String Phenomenology

    CERN Document Server

    Walker, J W

    2005-01-01

    Explored in this report is the essential interconnectedness of Grand Unified and String Theoretic Phenomenology. In order to extract a modeled connection to low-energy physics from the context of superstring theory, it is presently necessary to input some preferred region of parameter space in which to search. This need may be well filled by a parallel study of Grand Unification, which is by contrast in immediate proximity to a wealth of experimental data. The favored GUT so isolated may then reasonably transfer this phenomenological correlation to a string embedding, receiving back by way of trade a greater sense of primary motivation, and potentially enhanced predictability for parameters taken as input in a particle physics context. The Flipped SU(5) GUT will be our preferred framework in which to operate and first receives an extended study in a non-string derived setting. Of particularly timely interest are predictions for super-particle mass ranges and the interrelated question of proton decay lifetime....

  12. La masa de los grandes impactores

    Science.gov (United States)

    Parisi, M. G.; Brunini, A.

    Los planetas han sido formados fundamentalmente acretando masa a través de colisiones con planetesimales sólidos. La masa más grande de la distribución de planetesimales y las masas máxima y mínima de los impactores, han sido calculadas usando los valores actuales del período y de la inclinación de los planetas (Lissauer & Safronov 1991; Parisi & Brunini 1996). Recientes investigaciones han mostrado, que las órbitas de los planetas gigantes no han sufrido variaciones con el tiempo, siendo su movimiento regular durante su evolución a partir de la finalización de la etapa de acreción (Laskar 1990, 1994). Por lo tanto, la eccentricidad actual de los planetas gigantes se puede utilizar para imponer una cota máxima a las masas y velocidades orbitales de los grandes impactores. Mediante un simple modelo dinámico, y considerando lo arriba mencionado, obtenemos la cota superior para la masa del planetesimal más grande que impactó a cada planeta gigante al final de su etapa de acreción. El resultado más importante de este trabajo es la estimación de la masa máxima permitida para impactar a Júpiter, la cúal es ~ 1.136 × 10 -1, siendo en el caso de Neptuno ~ 3.99 × 10 -2 (expresada en unidades de la masa final de cada planeta). Además, fue posible obtener la velocidad orbital máxima permitida para los impactores como una función de su masa, para cada planeta. Las cotas obtenidas para la masa y velocidad de los impactores de Saturno y Urano (en unidades de la masa y velocidad final de cada planeta respectivamente) son casi las mismas que las obtenidas para Júpiter debido a que estos tres planetas poseen similar eccentricidad actual. Nuestros resultados están en buen acuerdo con los obtenidos por Lissauer & Safronov (1991). Estas cotas podrían ser utilizadas para obtener la distribución de planetesimales en el Sistema Solar primitivo.

  13. Gauge-Higgs EW and Grand Unification

    Science.gov (United States)

    Hosotani, Yutaka

    Four-dimensional Higgs field is identified with the extra-dimensional component of gauge potentials in the gauge-Higgs unifiation scenario. SO(5) × U(1) gauge-Higgs EW unification in the Randall-Sundrum warped space is successful at low energies. The Higgs field appears as an Aharonov-Bohm phase θH in the fifth dimension. Its mass is generated at the quantum level and is finite. The model yields almost the same phenomenology as the standard model for θH bosons around 6-10 TeV with very broad widths. The scenario is generalized to SO(11) gauge-Higgs grand unification. Fermions are introduced in the spinor and vector representations of SO(11). Proton decay is naturally forbidden.

  14. Gauge-Higgs EW and Grand Unification

    CERN Document Server

    Hosotani, Yutaka

    2016-01-01

    4D Higgs field is identified with the extra-dimensional component of gauge potentials in the gauge-Higgs unification scenario. $SO(5) \\times U(1)$ gauge-Higgs EW unification in the Randall-Sundrum warped space is successful at low energies. The Higgs field appears as an Aharonov-Bohm phase $\\theta_H$ in the fifth dimension. Its mass is generated at the quantum level and is finite. The model yields almost the same phenomenology as the standard model for $\\theta_H < 0.1$, and predicts $Z'$ bosons around 6 - 10 TeV with very broad widths. The scenario is genelarized to $SO(11)$ gauge-Higgs grand unification. Fermions are introduced in the spinor and vector representations of $SO(11)$. Proton decay is naturally forbidden.

  15. Recent Results from Kascade-Grande

    CERN Document Server

    Kampert, K H; Ainsley, C; Åkesson, P F; Alexander, G; Anagnostou, G; Anderson, K J; Asai, S; Axen, D; Bailey, I; Barberio, E; Barillari, T; Barlow, R J; Batley, J Richard; Bechtle, P; Behnke, T; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bethke, Siegfried; Biebel, O; Boeriu, O; Bock, P; Boutemeur, M; Braibant, S; Brown, R M; Burckhart, H J; Campana, S; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Ciocca, C; Csilling, A; Cuani, M; Dado, S; de Roeck, A; De Wolf, E A; Desch, K; Dienes, B; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Etzion, E; Fabbri, F; Ferrari, P; Fiedler, F; Fleck, I; Ford, M; Frey, A; Gagnon, P; Gary, J W; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Giunta, M; Goldberg, J; Gross, E; Grunhaus, J; Gruwé, M; Sen-Gupta, A; Hajdu, C; Hamann, M; Hanson, G G; Harel, A; Hauschild, M; Hawkes, C M; Hawkings, R; Herten, G; Heuer, R D; Hill, J C; Horváth, D; Igo-Kemenes, P; Ishii, K; Jeremie, H; Jovanovic, P; Junk, T R; Kanzaki, J; Karlen, D; Kawagoe, K; Kawamoto, T; Keeler, R K; Kellogg, R G; Kennedy, B W; Kluth, S; Kobayashi, T; Kobel, M; Komamiya, S; Kramer, T; Krasznahorkay, A; Krieger, P; Von Krogh, J; Kühl, T; Kupper, M; Laerty, G D; Landsman, H; Lanske, D; Lellouch, D; Letts, J; Levinson, L; Lillich, J; Lloyd, S L; Loebinger, F K; Lü, J; Ludwig, A; Ludwig, J; Mader, W; Marcellini, S; Martin, A J; Mashimo, T; Mättig, P; McKenna, J; McPherson, R A; Meijers, F; Menges, W; Merritt, F S; Mes, H; Meyer, N; Michelini, A; Mihara, S; Mikenberg, G; Miller, D J; Mohr, W; Mori, T; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nisius, R; O'Neale, S W; Oh, A; Oreglia, M J; Orito, S; Pahl, C; Pásztor, G; Pater, J R; Pilcher, J E; Pinfold, J L; Plane, D E; Pooth, O; Przybycien, M B; Quadt, A; Rabbertz, K; Rembser, C; Renkel, P; Roney, J M; Rossi, A M; Rozen, Y; Runge, K; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Schaile, A D; Schaile, O; Schar-Hansen, P; Schieck, J; Schörner-Sadenius, T; Schröder, M; Schumacher, M; Seuster, R; Shears, T G; Shen, B C; Sherwood, P; Skuja, A; Smith, A M; Sobie, R J; Söldner-Rembold, S; Spanó, F; Stahl, A; Strom, D; Ströhmer, R; Tarem, S; Tasevsky, M; Teuscher, R; Thomson, M A; Torrence, E; Toya, D; Tran, P; Trigger, I; Trócsányi, Z L; Tsur, E; Turner-Watson, M F; Ueda, I; Ujvári, B; Vollmer, C F; Vannerem, P; Vertesi, R; Verzocchi, M; Voss, H; Vossebeld, Joost Herman; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wengler, T; Wermes, N; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Zer-Zion, D; Zivkovic, L; Kampert, Karl-Heinz

    2006-01-01

    KASCADE-Grande is a new extensive air shower experiment co-located to the KASCADE site at Forschungszentrum Karlsruhe. The multi-detector system allows to investigate the energy spectrum, composition, and anisotropies of cosmic rays with unprecedented prevision in the energy range from 10^{14}-10^{18} eV. The primary goals besides investigating the origin of the knee at E ~ 3 * 10^{15} eV, are to verify the existence of the second knee at E ~ 10^{17} eV and to measure the composition in the expected transition region of galactic to extragalactic cosmic rays. The performance of the apparatus and shower reconstruction methods will be discussed on the basis of detailed Monte Carlo simulations and first data. First results based on slightly more than a year of data taking are presented.

  16. Grandes incendios urbanos: mesa redonda, Lima 2001

    Directory of Open Access Journals (Sweden)

    Juan L. Arce-Palomino

    2008-01-01

    Full Text Available Entre los desastres antrópicos destacan los grandes incendios urbanos. El 29 de diciembre de 2001, en un área comercial tugurizada del centro de Lima, Perú se produjo un gran incendio que causó 277 muertes, 247 heridos, millonarias pérdidas y un gran dolor en el pueblo peruano. Esta situación se había previsto, pero no se tomaron las acciones necesarias para evitarla. En este artículo se recopila la situación previa, las características de la tragedia, las acciones y organización que se tuvo para su control, se destaca el trabajo interdisciplinario y la una activa participación del Cuerpo General de Bomberos Voluntarios del Perú.

  17. Gauged flavor, supersymmetry and grand unification

    Science.gov (United States)

    Mohapatra, Rabindra N.

    2012-07-01

    I review a recent work on gauged flavor with left-right symmetry, where all masses and all Yukawa couplings owe their origin to spontaneous flavor symmetry breaking. This is suggested as a precursor to a full understanding of flavor of quarks and leptons. An essential ingredient of this approach is the existence of heavy vector-like fermions, which is the home of flavor, which subsequently gets transmitted to the familiar quarks and leptons via the seesaw mechanism. I then discuss implications of extending this idea to include supersymmetry and finally speculate on a possible grand unified model based on the gauge group SU(5)L×SU(5)R which provides a group theoretic origin for the vector-like fermions.

  18. Gauged Flavor, Supersymmetry and Grand Unification

    CERN Document Server

    Mohapatra, Rabindra N

    2012-01-01

    I review a recent work on gauged flavor with left-right symmetry, where all masses and all Yukawa couplings owe their origin to spontaneous flavor symmetry breaking. This is suggested as a precursor to a full understanding of flavor of quarks and leptons. An essential ingredient of this approach is the existence of heavy vector-like fermions, which is the home of flavor, which subsequently gets transmitted to the familiar quarks and leptons via the seesaw mechanism. I then discuss implications of extending this idea to include supersymmetry and finally speculate on a possible grand unified model based on the gauge group $SU(5)_L\\times SU(5)_R$ which provides a group theoretic origin for the vector-like fermions.

  19. A grand model for chemical product design

    DEFF Research Database (Denmark)

    Fung, Ka Y.; Ng, Ka M.; Zhang, Lei;

    2016-01-01

    Chemical engineering has been expanding its focus from primarily business-to-business products (B2B) to business-to-consumer (B2C) products. The production of B2B products generally emphasizes on process design and optimization, whereas the production of B2C products focuses on product quality......, ingredients and structure. Market and competitive analysis, government policies and regulations have to be explicitly considered in product design. All these considerations are accounted for in the Grand Product Design Model, which consists of a process model, a property model, a quality model, a cost model...... product composition changes with market conditions. Another is a hand lotion that illustrates how product quality affects the profit.(C) 2016 Elsevier Ltd. All rights reserved....

  20. Steroids from Dysoxylum grande (Meliaceae) leaves.

    Science.gov (United States)

    Wah, Low Kok; Abas, Faridah; Cordell, Geoffrey A; Ito, Hideyuki; Ismail, Intan Safinar

    2013-02-01

    Seven new 23-oxo-cholestane derivatives named as grandol A (1), B (2), C (3), D (4), E (5), F (6), and G (7) were isolated from Dysoxylum grande leaves alongside with a new 3,4-secodammar-4(28)-en-3-oic acid derivative (8). The structures of the compounds were elucidated based on the interpretation of spectroscopic data, and their relative configurations were established by NOESY 2D NMR data. All of the isolates were tested for anti-acetylcholinesterase activity using thin layer chromatography (TLC)-bioautography with fast blue B salt. Only grandol A (1) and B (2) showed positive results, with clear discoloration at a concentration of 12.5 ppm. However, the obtained IC(50) values for grandol A and B, when using Ellman's method, were not significant (>200 μg/ml).

  1. Las cubiertas de grandes luces. Soluciones actuales

    Directory of Open Access Journals (Sweden)

    de Alarcón Álvarez, C.

    1971-04-01

    Full Text Available This article deals generally with the problems connected with the construction of large span roofs, and also with the various types of designs that are currently in practice. It may be said that at present the only limitation to these designs is the imagination of the designer and the financial restrictions imposed on him.Se exponen en este artículo, de forma panorámica, los problemas que presenta la cobertura de grandes vanos y las diversas soluciones que se han adoptado hasta los tiempos actuales, en los que puede afirmarse que no existe más límite para la fantasía del proyectista que el condicionamiento del presupuesto de la obra.

  2. A unified grand tour of theoretical physics

    CERN Document Server

    Lawrie, Ian D

    2013-01-01

    A Unified Grand Tour of Theoretical Physics invites its readers to a guided exploration of the theoretical ideas that shape our contemporary understanding of the physical world at the fundamental level. Its central themes, comprising space-time geometry and the general relativistic account of gravity, quantum field theory and the gauge theories of fundamental forces, and statistical mechanics and the theory of phase transitions, are developed in explicit mathematical detail, with an emphasis on conceptual understanding. Straightforward treatments of the standard models of particle physics and cosmology are supplemented with introductory accounts of more speculative theories, including supersymmetry and string theory. This third edition of the Tour includes a new chapter on quantum gravity, focusing on the approach known as Loop Quantum Gravity, while new sections provide extended discussions of topics that have become prominent in recent years, such as the Higgs boson, massive neutrinos, cosmological perturba...

  3. Elastoplasticidad anisotropa de metales en grandes deformaciones

    Science.gov (United States)

    Caminero Torija, Miguel Angel

    El objetivo de este trabajo es el desarrollo de modelos y algoritmos numericos que simulen el comportamiento del material bajo estas condiciones en el contexto de programas de elementos finitos, dando como resultado predicciones mas precisas de los procesos de conformado y deformacion plastica en general. Para lograr este objetivo se han desarrollado diversas tareas destinadas a mejorar las predicciones en tres aspectos fundamentales. El primer aspecto consiste en la mejora de la descripcion del endurecimiento cinematico anisotropo en pequenas deformaciones, lo cual se ha realizado a traves de modelos y algoritmos implicitos de superficies multiples. Ha sido estudiada la consistencia de este tipo de modelos tanto si estan basados en una regla implicita similar a la de Mroz o en la regla de Prager. Ademas se han simulado los ensayos de Lamba y Sidebottom, obteniendo, en contra de la creencia general, muy buenas predicciones con la regla de Prager. Dichos modelos podrian ser extendidos de forma relativamente facil para considerar grandes deformaciones a traves de procedimientos en deformaciones logaritmicas, similares a los desarrollados en esta tesis y detallados a continuacion. El segundo aspecto consiste en la descripcion de la anisotropia elastoplastica inicial. Esto se ha conseguido mediante el desarrollo de modelos y algoritmos para plasticidad anisotropa en grandes deformaciones, bien ignorando la posible anisotropia elastica, bien considerandola simultaneamente con la anisotropia plastica. Para ello ha sido necesario desarrollar primero un nuevo algoritmo de elastoplasticidad anisotropa en pequenas deformaciones consistentemente linealizado y sin despreciar ningun termino, de tal forma que se conserve la convergencia cuadratica de los metodos de Newton. Este algoritmo en pequenas deformaciones ha servido para realizar la correccion plastica de dos algoritmos en grandes deformaciones. El primero de estos algoritmos es una variacion del clasico algoritmo de

  4. 36 CFR 7.22 - Grand Teton National Park.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Grand Teton National Park. 7.22 Section 7.22 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.22 Grand Teton National Park. (a)...

  5. 36 CFR 7.4 - Grand Canyon National Park.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Grand Canyon National Park. 7.4 Section 7.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR SPECIAL REGULATIONS, AREAS OF THE NATIONAL PARK SYSTEM § 7.4 Grand Canyon National Park. (a)...

  6. Gauge coupling unification in gauge-Higgs grand unification

    Science.gov (United States)

    Yamatsu, Naoki

    2016-04-01

    We discuss renormalization group equations for gauge coupling constants in gauge-Higgs grand unification on five-dimensional Randall-Sundrum warped space. We show that all four-dimensional Standard Model gauge coupling constants are asymptotically free and are effectively unified in SO(11) gauge-Higgs grand unified theories on 5D Randall-Sundrum warped space.

  7. Grand Hyatt Beijing Opens Wine Shop in the Patisserie

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Over the years,Grand Hyatt Beijing has become a crowd favorite for wine events thanks to events such as its many exquisite wine dinners at the hotel’s superb Italian restaurant Da Giorgio,the Wine Club at Redmoon and the Grand Wine Sale at the Patisserie."The wine shop will cater to Beijing’s growing community of wine

  8. Future challenges in colloid and interfacial science.

    Science.gov (United States)

    Möhwald, Helmuth

    2010-01-01

    This article deals with topics where I expect special future challenges, exemplifying these by experiments out of my own department. One area where I expect large progress also in view of many technical developments in the past concerns the understanding of the structure of fluid interfaces at the atomic level. It is shown by non-linear optical spectroscopies that the free water surface is ice-like and can be "liquefied" by ion adsorption. X-ray fluorescence from the interface demonstrates that ion binding is very specific which cannot be explained by existing theories. A second major area are nonequilibrium features, and one of the old and new ones here is nucleation and growth. This presentation concentrates on effects produced by ultrasound, a well-defined trigger of gas bubble formation. It exhibits high potential for chemistry at extreme conditions but with a reactor at normal conditions. It has special importance for treatment of surfaces that can be also manipulated via controlled surface energies. A third area will concern complex and smart systems with multiple functions in materials and biosciences. As next generation, I anticipate those with feedback control, and examples on this are self-repairing coatings.

  9. Multiple Time and Spatial Scale Plasma Simulation -Prospect Based on Current Status- 5.Prospect for Multiple Time and Spatial Scale Simulation Research in Astrophysical Plasma Phenomena 5.2Grand Challenge for Studying the History of Universe from the Dark Ages to the Solar System

    Science.gov (United States)

    Takabe, Hideaki; Computational Observatory Project, Hideaki

    We intend to reveal the physics of the evolution of the Universe from the pre-formation stage of the first stars to the structure and phenomena of the present solar system through the use of large-scale supercomputing. This project is named ”Computational Observatory” and sixteen research groups from throughout Japanare attempting simulations of four subjects in the different phases of the evolution of the Universe after the dark ages. This project involves finding numerical methods to very hierarchical problems regarding space and time. At the same time, a variety of complex physics should be modeled in the codes that are to be developed. A so-called integrated code for each subject should be developed. The integrated codes, of course, should be checked and improved through comparisons with observational and experimental data. Throughout this project, we would like to analyze not only observational data but also to predict, for example, what new findings we could obtain if we increase the resolution of observation instruments in the future. This project consists a great challenge in computer science in regard to developing a highly integrated system with very hierarchical phenomena..

  10. 75 FR 13138 - Grand Ditch Breach Restoration Environmental Impact Statement, Rocky Mountain National Park, CO

    Science.gov (United States)

    2010-03-18

    ... National Park Service Grand Ditch Breach Restoration Environmental Impact Statement, Rocky Mountain... prepare an Environmental Impact Statement for the Grand Ditch Breach Restoration, Rocky Mountain National...), the National Park Service is preparing an Environmental Impact Statement for the Grand Ditch...

  11. 77 FR 14418 - Grand Ditch Breach Restoration Draft Environmental Impact Statement, Rocky Mountain National Park...

    Science.gov (United States)

    2012-03-09

    ... National Park Service Grand Ditch Breach Restoration Draft Environmental Impact Statement, Rocky Mountain... of the Draft Environmental Impact Statement for the Grand Ditch Breach Restoration, Rocky Mountain... Grand Ditch Breach Restoration, Rocky Mountain National Park, Colorado. The purpose of...

  12. D2 dining center wins whole grains challenge

    OpenAIRE

    Dawson, Brandi

    2007-01-01

    The Whole Grains Council and Oldways food issues advocacy group challenged restaurants and foodservice operations across the country to step up to the plate and offer more whole grain options this summer. Virginia Tech's Dining Services did just that and swept the competition, winning the college/university category, as well as the grand prize, beating out entries from nine other categories.

  13. Graph analytics-lessons learned and challenges ahead.

    Science.gov (United States)

    Pak Chung Wong; Chaomei Chen; Gorg, C; Shneiderman, B; Stasko, J; Thomas, J

    2011-01-01

    Lessons learned from developing four graph analytics applications reveal good research practices and grand challenges for future research. The application domains include electric-power-grid analytics, social-network and citation analytics, text and document analytics, and knowledge domain analytics.

  14. Challenged Pragmatism

    DEFF Research Database (Denmark)

    Christoffersen, Lisbet; Vinding, Niels Valdemar

    2013-01-01

    of religious faith have made religious claims and thereby challenged a secular understanding of the Danish labour market. This raises the question of the extent to which the religion of the individual can be accepted in the general public sphere. At the same time, religious ethos organisations have argued...

  15. A unified grand tour of theoretical physics

    CERN Document Server

    Griffiths, J

    2002-01-01

    Anyone offering a grand tour is faced with several options. Should they concentrate on what may be considered to be essential features, or should they attempt to present a brief glimpse of almost everything? The present offering is a compromise between these two extremes. The area considered - theoretical physics - is now such a vast subject that some kind of compromise is essential. Indeed, the field is now so wide that few could even attempt to review it in a single-authored work. My task here is to assess how well this book has succeeded in its main aim of providing a unified (though introductory) tour of this subject. Constrained within a single volume, this is clearly not an updated Landau-Lifschitz. It cannot be expected to take any particular topic to the level of recent research. Nevertheless, it does seem to cover the broad range of essential topics which now constitute the subject. It starts (most appropriately in my opinion) with geometry. It then covers classical physics, general relativity and qu...

  16. Toward Realistic Gauge-Higgs Grand Unification

    CERN Document Server

    Furui, Atsushi; Yamatsu, Naoki

    2016-01-01

    The $SO(11)$ gauge-Higgs grand unification in the Randall-Sundrum warped space is presented. The 4D Higgs field is identified as the zero mode of the fifth dimensional component of the gauge potentials, or as the fluctuation mode of the Aharonov-Bohm phase $\\theta_H$ along the fifth dimension. Fermions are introduced in the bulk in the spinor and vector representations of $SO(11)$. $SO(11)$ is broken to $SO(4) \\times SO(6)$ by the orbifold boundary conditions, which is broken to $SU(2)_L \\times U(1)_Y \\times SU(3)_C$ by a brane scalar. Evaluating the effective potential $V_{\\rm eff} (\\theta_H)$, we show that the electroweak symmetry is dynamically broken to $U(1)_{\\rm EM}$. The quark-lepton masses are generated by the Hosotani mechanism and brane interactions, with which the observed mass spectrum is reproduced. The proton decay is forbidden thanks to the new fermion number conservation. It is pointed out that there appear light exotic fermions. The Higgs boson mass is determined with the quark-lepton masses ...

  17. y las grandes ciudades: 1970-2004

    Directory of Open Access Journals (Sweden)

    Adrián de León Arias

    2008-01-01

    Full Text Available El cambio regional en las manufacturas mexicanas a partir de la década de 1980 se ha caracterizado por el rápido crecimiento del empleo y la producción en la frontera norte del país y la pérdida de participación de ellos en las grandes ciudades. En este artículo se analiza y evalúa este cambio regional en términos de la dinámica de la productividad laboral y factorial total para ambas configuraciones espaciales, presentando cálculos de productividad para éstas de 1970 a 2004, estimados a partir de la información censal. Los resultados sugieren que mientras el empleo ha crecido en magnitud mucho más rápido en la frontera norte, esta dinámica se ha generado con bajos niveles en crecimiento de la productividad, al menos hasta fechas recientes, por lo que el cambio regional estimulado por la apertura comercial hasta 2004 no parece haber facilitado un crecimiento económico más acelerado para México

  18. Local grand unification in the heterotic landscape

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Jonas

    2009-07-15

    We consider the possibility that the unification of the electroweak interactions and the strong force arises from string theory, at energies significantly lower than the string scale. As a tool, an effective grand unified field theory in six dimensions is derived from an anisotropic orbifold compactification of the heterotic string. It is explicitly shown that all anomalies cancel in the model, though anomalous Abelian gauge symmetries are present locally at the boundary singularities. In the supersymmetric vacuum additional interactions arise from higher-dimensional operators. We develop methods that relate the couplings of the effective theory to the location of the vacuum, and find that unbroken discrete symmetries play an important role for the phenomenology of orbifold models. An efficient algorithm for the calculation of the superpotential to arbitrary order is developed, based on symmetry arguments. We furthermore present a correspondence between bulk fields of the orbifold model in six dimensions, and the moduli fields that arise from compactifying four internal dimensions on a manifold with non-trivial gauge background. (orig.)

  19. La grande bellezza (P. Sorrentino, 2013

    Directory of Open Access Journals (Sweden)

    Daniela Brogi

    2013-05-01

    Full Text Available Qual è il soggetto della Grande bellezza? Di cosa parla il film, mentre racconta come sta al mondo Jep Gambardella? Ripartiamo dalla traccia narrativa: Jep si è trasferito a Roma da giovane, in cerca di successo – come tanti, come tutti – per occupare il centro della mondanità e diventarne imperatore, tanto da essere distolto dalla cura del proprio talento (a venticinque anni aveva conquistato la fama col suo primo e unico romanzo L’apparato umano; quarant’anni più tardi, lo guardiamo vivere: essenzialmente senza far nulla, mentre divaga continuamente, tra feste in terrazza, incontri, passaggi onirici e camminate solitarie sul Tevere; intanto giunge la notizia della morte della donna di cui era stato innamorato da ragazzo. Qual è, dunque, la storia più vera messa in scena? Quella di un’ambizione implosa? Quella dello sperpero esistenziale della mondanità capitolina? Quella di una crisi d’identità e del tentativo di ritrovare una spiritualità? Quella di Roma? 

  20. Toward realistic gauge-Higgs grand unification

    Science.gov (United States)

    Furui, Atsushi; Hosotani, Yutaka; Yamatsu, Naoki

    2016-09-01

    The SO(11) gauge-Higgs grand unification in the Randall-Sundrum warped space is presented. The 4D Higgs field is identified as the zero mode of the fifth-dimensional component of the gauge potentials, or as the fluctuation mode of the Aharonov-Bohm phase θ along the fifth dimension. Fermions are introduced in the bulk in the spinor and vector representations of SO(11). SO(11) is broken to SO(4)×SO(6) by the orbifold boundary conditions, which is broken to SU2×U1×SU3 by a brane scalar. Evaluating the effective potential V(θ), we show that the electroweak symmetry is dynamically broken to U1. The quark-lepton masses are generated by the Hosotani mechanism and brane interactions, with which the observed mass spectrum is reproduced. Proton decay is forbidden thanks to the new fermion number conservation. It is pointed out that there appear light exotic fermions. The Higgs boson mass is determined with the quark-lepton masses given; however, it turns out to be smaller than the observed value.

  1. The grand descent has begun for CMS

    CERN Multimedia

    2006-01-01

    Until recently, the CMS experimental cavern looked relatively empty; its detector was assembled entirely at ground level, to be lowered underground in 15 sections. On 2 November, the first hadronic forward calorimeter led the way with a grand descent. The first section of the CMS detector (centre of photo) arriving from the vertical shaft, viewed from the cavern floor. There is something unusual about the construction of the CMS detector. Instead of being built in the experimental cavern, like all the other detectors in the LHC experiments, it was constructed at ground level. This was to allow for easy access during the assembly of the detector and to minimise the size of the excavated cavern. The slightly nerve-wracking task of lowering it safely into the cavern in separate sections came after the complete detector was successfully tested with a magnetic field at ground level. In the early morning of 2 November, the first section of the CMS detector began its eagerly awaited descent into the underground ca...

  2. desenvolvimento para o Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Benedito Silva Neto

    2005-01-01

    Full Text Available The paper discusses the role that the milk production can carry out in a development strategy for the Rio Grande do Sul State (Brazil. It was verified that an important contribution that the milk production could provide to the development it derives of its capacity of maintenance of the population in the rural zones, which enhance its effects on the local economies. These effects are generated by the high potential of aggregation of value that the dairy activity can provide in a direct, indirect and induced way. So for the milk production can play this function, however, it is necessary orientate the current policies sustained by the representatives of the agro-industrial chain that can lead more than two thirds of the producers to the exclusion in the short period. The main conclusion of the paper is that the promotion of production systems adapted to the conditions of the family production would be an indispensable condition for the construction of a development model more equitable and balanced territorially

  3. The People-First Service of Grand Hotel Beijing

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Grand Hotel Beijing is located north of Chang’an Avenue and east of the landmark Forbidden City in Beijing.This five-star luxury hotel has received numerous government delegations and state leaders from around the world since it opened in 1990.Wang Fuhe has been General Manager of Grand Hotel Beijing for more than 10 years.Through the effortsofWangandhisteam,thehotelflagshipsteers steady and fast,taking a leading position among the countless luxury hotels in Beijing.Wang attributes the success of Grand Hotel Beijing to its distinctive

  4. Mastoplastia reductora en L para grandes volúmenes

    OpenAIRE

    Fernandez, Claudio de Barros

    2013-01-01

    Las primeras descripciones de las mastoplastias fueron atribuidas a Paulus Aegineta en 625-690d.C. 4, con una resección de ginecomastia por el surco sub-mamario. Posteriormente, muchas técnicas fueron descritas para la disminución del órgano. Clásicamente, fueron consideradas mamas grandes aquellas con volúmenes resecados más grandes que 600 gr., siendo la mayoría tratadas tras cicatrices en T invertido. El objetivo de ese estudio es mostrar que es posible tratar mamas grandes con cicatrices ...

  5. Mastoplastia reductora en l para grandes volúmenes

    OpenAIRE

    De Barros Fernandez, Claudio

    2012-01-01

    Las primeras descripciones de las mastoplastias fueron atribuidas a Paulus Aegineta en 625-690d.C. 4, con una resección de ginecomastia por el surco sub-mamario. Posteriormente, muchas técnicas fueron descritas para la disminución del órgano. Clásicamente, fueron consideradas mamas grandes aquellas con volúmenes resecados más grandes que 600 gr., siendo la mayoría tratadas tras cicatrices en T invertido. El objetivo de ese estudio es mostrar que es posible tratar mamas grandes ...

  6. Coesão social e integração regional: a agenda social do MERCOSUL e os grandes desafios das políticas sociais integradas Social cohesion and regional integration: the MERCOSUR social agenda and the integrationist social policy major challenges

    Directory of Open Access Journals (Sweden)

    Sônia Miriam Draibe

    2007-01-01

    reflection on the current dilemmas and challenges faced by the process. According to the study, MERCOSUR operates with strategies that are difficult to mutually reconcile. On the institutional level, it follows a minimalist strategy, while on the conceptual/ discursive level it adopts a maximalist strategy for supranational unification of social policies. The fact is that it operates a minimalist social policy strategy, since it fails to bring to the field of social integration the debate and proposals on economic and social development models that could sustain the effective construction of regional social citizenship.

  7. Albuquerque/Middle Rio Grande Urban Waters Viewer

    Data.gov (United States)

    U.S. Environmental Protection Agency — These data have been compiled in support of the Middle Rio Grande/Albuquerque Urban Waters Partnership for the region including Albuquerque, New Mexico.The Middle...

  8. VT Built Up Lands in Grand Isle County - 1977

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  9. VT Built Up Lands in Grand Isle County - 1941

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  10. VT Built Up Lands in Grand Isle County - 1974

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  11. VT Built Up Lands in Grand Isle County - 2003

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  12. VT Built Up Lands in Grand Isle County - 1986

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  13. VT Developed Lands in Grand Isle County - 2003

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  14. VT Built Up Lands in Grand Isle County - 1980

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  15. VT Built Up Lands in Grand Isle County - 1995

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  16. VT Built Up Lands in Grand Isle County - 1962

    Data.gov (United States)

    Vermont Center for Geographic Information — (Link to Metadata) NRCS mapped historical and current-day built-up lands for Grand Isle County, VT using several vintages of aerial photography: 1941, 1962, 1974,...

  17. Grand Bay National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Grand Bay NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  18. Casa Grande Ruins National Monument Vegetation Mapping Project - Plot Locations

    Data.gov (United States)

    National Park Service, Department of the Interior — This layer contains spatial information for 25 plots sampled during vegetation mapping and classification efforts at Casa Grande Ruins NM, AZ. Data was collected by...

  19. Kevadise lilleseadevõistluse Grand Deco 2004 eelvoor / Piret Veigel

    Index Scriptorium Estoniae

    Veigel, Piret, 1961-

    2004-01-01

    17.-18. IV toimub Palmse mõisas rahvusvaheline lilleseade meistrivõistlus Grand Deco 2004, korraldajaks firma Tourinest. Žürii esimees Michael Bowyer Suurbritanniast. Eestit esindab žüriis Priit Press. Eelvoorus osalemisest

  20. The KASCADE-Grande Experiment and the LOPES Project

    CERN Document Server

    Badea, A F; Apel, W D; Bekk, K; Bercuci, A; Bertaina, M; Blümer, H; Bozdog, H; Brancus, I M; Bruggemann, M; Bucholz, P; Chiavassa, A; Daumiller, K; di Pierro, F; Doll, P; Engel, R; Engler, J; Falcke, H; Fessler, F; Ghia, P L; Gils, H J; Glasstetter, R; Haungs, A; Heck, D; Hörandel, J R; Horneffer, A; Huege, T; Kampert, K H; Kant, G W; Klages, H O; Kolotaev, Yu; Maier, G; Mathes, H J; Mayer, H J; Milke, J; Morello, C; Müller, M; Navarra, G; Obenland, R; Oehlschläger, J; Ostapchenko, S; Petcu, M; Plewnia, S; Rebel, H; Risse, A; Roth, M; Schieler, H; Scholz, J; Stumpert, M; Thouw, T; Toma, G; Trinchiero, G C; Ulrich, H; Valchierotti, S; Van Buren, J; De Vos, C M; Walkowiak, W; Weindl, A; Wochele, J; Zabierowski, J; Zagromski, S; Zimmermann, D

    2004-01-01

    KASCADE-Grande is the extension of the multi-detector setup KASCADE to cover a primary cosmic ray energy range from 100 TeV to 1 EeV. The enlarged EAS experiment provides comprehensive observations of cosmic rays in the energy region around the knee. Grande is an array of 700 x 700 sqm equipped with 37 plastic scintillator stations sensitive to measure energy deposits and arrival times of air shower particles. LOPES is a small radio antenna array to operate in conjunction with KASCADE-Grande in order to calibrate the radio emission from cosmic ray air showers. Status and capabilities of the KASCADE-Grande experiment and the LOPES project are presented.

  1. Grand Performances: Building Self and Social Ties through Theatrical Performance

    Directory of Open Access Journals (Sweden)

    Stephanie May de Montigny

    2015-05-01

    Full Text Available The stories that individuals tell about their experiences on stage and behind-the-scenes at the Grand Opera House of Oshkosh, Wisconsin, contribute to their knowledge of self and social ties.

  2. Grand Cote National Wildlife Refuges Habitat Management Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — The Grand Cote NWR Habitat Management Plan provides a long-term vision and specific guidance on managing habitats for the resources of concern at the Refuge, to...

  3. Grand Cote National Wildlife Refuge [Land Status Map

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This map was produced by the Division of Realty to depict landownership at Grand Cote National Wildlife Refuge. It was generated from rectified aerial photography,...

  4. Grand Cote National Wildlife Refuge: Comprehensive Conservation Plan

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This Comprehensive Conservation Plan (CCP) was written to guide management on Grand Cote NWR for the next 15 years. This plan outlines the Refuge vision and purpose...

  5. Mobility Challenges

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lassen, Claus

    2011-01-01

    This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part of th...... mobilities. In particular the article discusses 1) the physical city, its infrastructures and technological hardware/software, 2) policies and planning strategies for urban mobility and 3) the lived everyday life in the city and the region.......This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part...... of the so-called ‘mobility turn’ within social science. The perspective is illustrative for the research efforts at the Centre for Mobility and Urban Studies (C-MUS), Aalborg University. The article presents the contours of a theoretical perspective meeting the challenges to research into contemporary urban...

  6. Tres grandes plataformas marinas Mar del Norte

    Directory of Open Access Journals (Sweden)

    Soulas, R.

    1978-03-01

    Full Text Available This article analyzes the different building stages of three large sea platforms. After studying the structure's main characteristics, preparing scale models and calculating ail the elements, platform construction was carried out in three stages: — Dry-dock construction of the hull base. — Installation in the water and finishing the structure. — Immersion and bridge installation. Finally, the necessary operations to move the platform to its definite location were carried out. The structures are formed by a parallelepiped hull of reinforced concrete, divided into compartments by means of vertical orthogonals panels on top of which 2 or 4 piles are placed to support the bridge.

    En este artículo se analizan las diversas etapas en la realización de tres grandes plataformas marinas. Después de un estudio de las características principales de la estructura, ensayos en modelo reducido y cálculo de todos los elementos, se procede a la construcción de las plataformas en tres fases: — Construcción en seco de la base del casco. — Colocación en el agua y acabado de la estructura. — Inmersión y colocación del puente. Por último, se realizan las operaciones necesarias para llevar la plataforma a su ubicación definitiva. Las estructuras están formadas por un casco paralelepipédico de hormigón armado, dividido en compartimientos mediante tabiques verticales ortogonales y sobre el que se han colocado 2 ó 4 pilas que soportan el puente.

  7. South African Formula One Grand Prix: a dream or nightmare.

    OpenAIRE

    2008-01-01

    In 2004 a group of South African based companies submitted a bid to the Formula One Management to host a South African Formula One Grand Prix, from 2009 in Cape Town. The group approached the government to establish a public-private partnership, due to the: • escalating hosting and infrastruture development cost, resulting in very few Formula One Grand Prix host countries undertaking hosting without government involvement; and • believe that the economic benefits of hosting the event would st...

  8. Simulations of Precipitation Variability over the Upper Rio Grande Basin

    Energy Technology Data Exchange (ETDEWEB)

    Costigan, Keeley R.; Bossert, James E.; Langley, David L.

    1997-12-31

    In this research, we study Albuquerque`s water and how it may be affected by changes in the regional climate, as manifested by variations in Rio Grande water levels. To do this, we rely on the use of coupled atmospheric, runoff, and ground water models. Preliminary work on the project has focused on uncoupled simulations of the aquifer beneath Albuquerque and winter precipitation simulations of the upper Rio Grande Basin. The latter is discussed in this paper.

  9. Environmental Assessment: Demolish 452 at Grand Forks Air Force Base

    Science.gov (United States)

    2005-12-01

    Preserve” has been developed to restore a part of the native tallgrass prairie that once was dominant in this region. Plants thriving in this...native wildflower species. The Grand Forks AFB Natural Resources Manager installed a butterfly garden in the Prairie View Nature 32 Preserve in the...characterized as typical prairie potholes found within the northern plains ecoregion. 31 Wetlands on Grand Forks AFB occur frequently in drainage

  10. The canonical and grand canonical models for nuclear multifragmentation

    Indian Academy of Sciences (India)

    G Chaudhuri; S Das Gupta

    2010-08-01

    Many observables seen in intermediate energy heavy-ion collisions can be explained on the basis of statistical equilibrium. Calculations based on statistical equilibrium can be implemented in microcanonical ensemble, canonical ensemble or grand canonical ensemble. This paper deals with calculations with canonical and grand canonical ensembles. A recursive relation developed recently allows calculations with arbitrary precision for many nuclear problems. Calculations are done to study the nature of phase transition in nuclear matter.

  11. Grand Bay-Banks Lake Stewardship Partnership - Phase 2

    Science.gov (United States)

    2006-11-01

    depending upon the drop from the Shiner Pond dike at full pool to the bottom of the original natural drain (not the swamp floor ) below. No mill...county would be appropriate. Similar soils at Craig’s Pond are mapped as: 1) Ogeechee - fine-loamy, siliceous, thermic Typic Ochraquults 2) Rembert...clayey, kaolinitic, thermic Typic Ochraquults These two soils have clayey textures very similar to those on the bottom of Grand Bay Grand Bay

  12. Multicenter Evaluation of Meridian Bioscience HSV 1&2 Molecular Assay for Detection of Herpes Simplex Virus 1 and 2 from Clinical Cutaneous and Mucocutaneous Specimens.

    Science.gov (United States)

    Faron, Matthew L; Ledeboer, Nathan A; Patel, Anami; Beqa, Safedin H; Yen-Lieberman, Belinda; Kohn, Debra; Leber, Amy L; Mayne, Donna; Northern, William I; Buchan, Blake W

    2016-08-01

    Herpes simplex virus (HSV) causes acute and relapsing symptoms characterized by ulcerative lesions. Laboratory diagnosis of HSV in cutaneous or mucocutaneous lesions has historically been performed with the use of viral cell culture systems; however, these tests are laborious and suffer decreased sensitivity for advanced-stage lesions. The recent availability of FDA-cleared moderately complex assays has resulted in the increased use of molecular diagnostics for the routine detection of HSV in superficial swab specimens. We performed a clinical evaluation of the recently FDA-cleared illumigene HSV 1&2 loop-mediated isothermal amplification (LAMP) assay (Meridian Bioscience, Cincinnati OH) for the detection and differentiation of HSV-1 and HSV-2 in cutaneous and mucocutaneous swab specimens. A total of 1,153 clinical swab specimens were collected and tested at 7 different clinical centers. Each specimen was tested for the presence of HSV-1 and HSV-2 using the illumigene assay, and results were compared to those of the enzyme-linked virus-inducible system (ELVIS) as the reference method. Overall, the illumigene assay demonstrated a sensitivity and specificity of 94.8% and 95.5%, respectively, for the detection of HSV-1. Detection of HSV-2 was similar, with a sensitivity of 98.9% and a specificity of 95.5%. Discrepant analysis was performed using an alternative molecular test (AmpliVue HSV1+2 assay; Quidel Molecular, San Diego, CA) on 91/99 specimens that were recorded as false positive (FP) or false negative (FN) compared to the reference method. In total, 57/78 (73%) FP and 9/13 (69%) FN illumigene results were supported by the AmpliVue result. The illumigene HSV 1&2 assay demonstrated high sensitivity and specificity to detect and differentiate HSV in clinical specimens and identified 57 additional specimens that were positive for HSV compared to culture. The use of LAMP eliminates the need for the cycling of temperatures and provides results in less than 60 min

  13. Fauna reptiliana do norte da grande Porto Alegre, Rio Grande do Sul, Brasil

    Directory of Open Access Journals (Sweden)

    Thales de Lema

    1983-01-01

    Full Text Available This paper reports the preliminary results of two years of herpetogeographic studies in the region called «Grande Porto Alegre» at its northern portion. The physiognomy shows, at North, slopes of the Brazilian Southern Plateau, more or less forested in a general view; these elevations graãuálly decrease to the South until the levei of the sea to Atlantic littoral by the eastern border, and to Rio Grande do Sul savanah, which extends to Uruguay and Argentina. The biota is transitional from the highland prairies and forests of the plateau to lowland prairies of the pampas. Three faunistic Provinces are included: Guarani, Pampean, and Tupi. The most conspicuous dispersion is shown by the taxa proceeding from the plateau to savanah (Dispersion Centre Guarani; the pampean species occur in low percentage (Dispersion Centre Uruguay, and an inappreciable account of Tupi fauna (Dispersion Centre of «Serra do Mar». The new records are: presence of Chironius pyrrhopogon, Hydrodynastes gigas, Bothrops neuwiedi para-naensis, Micrurus corallinus; intergradation zone of Guarani and Pampean geographic roces; and new taxa of snakes, which will be described brieflly. The systematic composition presents: Chelonia, 4 (3 Chelidae, 1 Testudinidae; Sauria, 10 (1 Gekkonidae, 2 Iguanidae, 1 Anguidae, 3 Teiidae, 3 Amphisbaenidae; Serpentes, 45 (35 Colubridae, 4 Elapidae, 6 Viperidae; Crocodylia (1 Crocodylidae.

  14. A COMPARATIVE STUDY TO ASSES THE OUTCOME OF GRAND MULTIPARA WITH THAT OF GREAT GRAND MULTIPARA

    Directory of Open Access Journals (Sweden)

    Nayana

    2015-01-01

    Full Text Available NEED FOR THE STUDY: In a developing country like India , where poverty , illiteracy , ignorance and lack of knowledge of family planning facilities available have greatly increased the incidence of grandmultipara 2. Grandmultipara has been associated with increased maternal morbidity and mortality rat es as well as poor outcome. The investigator is interested in finding out the outcome in grand multipara women and great grand multipara 1 women during the antenatal , internatal and postnatal period , and also to analyze demographic characteristics such as socioeconomic status and religion of the sample. STATEMENT OF THE PROBLEM: A comparative study to assess the outcome of grandmultipara (1 with that of grandmultipara women. OBJECTIVE OF THE STUDY: 1. To findout the outcome of grandmultipara women during th e antenatal , internatal and postnatal period. 2. To find the outcome of great grandmultipara women during the antenatal , internatal (2 and postnatal period. 3. To compare the outcomes of grandmultipara with that of non - grandmultipara women during the anten atal , internatal and postnatal (3 period. ( 4 To analyze the demographic characteristics 6 of the sample i.e. income and religion.

  15. Policy to support marine biotechnology-based solutions to global challenges.

    Science.gov (United States)

    Ritchie, Rachael J; Guy, Ken; Philp, Jim C

    2013-03-01

    Recent advances in science and technology are igniting new interest in marine biotechnology. Governments are recognizing the potential of marine biotechnology to provide solutions to grand global challenges of population health, food, and energy security and sustainable industry. This paper examines some of the challenges to and policy options for the development of marine biotechnology.

  16. Challenging Identities

    DEFF Research Database (Denmark)

    Keydar, Ceglar; Marin, Manuela; Janik, Allan;

    , cultural, and political practices. Notions of national identity and national politics are challenged by European integration, as well as by increasing demographic heterogeneity due to migration, and migrants experience conflicts of identification stemming from clashes between cultural heritage...... and the cultures of the new habitat. European horizons—frames of mind, historical memories, and expectations at the level of groups or communities, at the national level, and at the general European level—are at odds. Analyzing a series of issues in European countries from Turkey to Spain and from Scandinavia...

  17. 3D View of Grand Canyon, Arizona

    Science.gov (United States)

    2000-01-01

    The Grand Canyon is one of North America's most spectacular geologic features. Carved primarily by the Colorado River over the past six million years, the canyon sports vertical drops of 5,000 feet and spans a 445-kilometer-long stretch of Arizona desert. The strata along the steep walls of the canyon form a record of geologic time from the Paleozoic Era (250 million years ago) to the Precambrian (1.7 billion years ago).The above view was acquired by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument aboard the Terra spacecraft. Visible and near infrared data were combined to form an image that simulates the natural colors of water and vegetation. Rock colors, however, are not accurate. The image data were combined with elevation data to produce this perspective view, with no vertical exaggeration, looking from above the South Rim up Bright Angel Canyon towards the North Rim. The light lines on the plateau at lower right are the roads around the Canyon View Information Plaza. The Bright Angel Trail, which reaches the Colorado in 11.3 kilometers, can be seen dropping into the canyon over Plateau Point at bottom center. The blue and black areas on the North Rim indicate a forest fire that was smoldering as the data were acquired on May 12, 2000.Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of International Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products. Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. Science team leader; Moshe Pniel of JPL is the project manager. ASTER is the only high resolution imaging sensor on Terra. The primary goal of the ASTER mission is to obtain high-resolution image data in 14 channels over the entire land surface, as

  18. Cassini's Grand Finale: The Final Orbits

    Science.gov (United States)

    Spilker, Linda; Edgington, Scott

    2016-04-01

    The Cassini-Huygens mission, a joint collaboration between NASA, ESA and the Italian Space Agency, is approaching its last year of operations after nearly 12 years in orbit around Saturn. Cassini will send back its final bits of unique data on September 15th, 2017 as it plunges into Saturn's atmosphere, vaporizing and satisfying planetary protection requirements. Before that time Cassini will continue its legacy of exploration and discovery with 12 close flybys of Titan in 2016 and 2017 that will return new science data as well as sculpt the inclinations and periods of the final orbits. Even though all of our close icy satellite flybys, including those of Enceladus, are now completed, numerous Voyager-class flybys (summer solstice approaches. In November 2016 Cassini will transition to a series of orbits with peripases just outside Saturn's F ring. These 20 orbits will include close flybys of some tiny ring moons and excellent views of the F ring and outer A ring. The 126th and final close flyby of Titan will propel Cassini across Saturn's main rings and into its final orbits. Cassini's Grand Finale, starting in April 2017, is comprised of 22 orbits at an inclination of 63 degrees. Cassini will repeatedly dive between the innermost rings and the upper atmosphere of the planet providing insights into fundamental questions unattainable during the rest of the mission. Cassini will be the first spacecraft to explore this region. These close orbits provide the highest resolution observations of both the rings and Saturn, and direct in situ sampling of the ring particles, composition, plasma, Saturn's exosphere and the innermost radiation belts. Saturn's gravitational field will be measured to unprecedented accuracy, providing information on the interior structure of the planet, winds in the outer layers of Saturn's atmosphere, and the mass distribution in the rings. Probing the magnetic field will give insight into the nature of the magnetic dynamo, telling us: why the

  19. Enterotoxemia em caprinos no Rio Grande do Sul Caprine enterotoxaemia in Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Edson M. Colodel

    2003-12-01

    Full Text Available São descritos surtos de enterotoxemia em caprinos em cinco propriedades no Estado do Rio Grande do Sul. Os animais afetados eram, normalmente, encontrados mortos ou apresentavam evolução aguda de 2 a 3 horas com acentuada depressão, cólicas abdominais e diarréia profusa com fibrina. Em duas propriedades relataram-se casos com a evolução de até 12 horas. Em treze animais necropsiados observaram-se aumento de líquidos nas cavidades abdominal, torácica e pericárdica, congestão e hiperemia da serosa e mucosa do intestino, conteúdo do cólon líquido com fibrina além de hemorragias de serosa e fibrina. Em um animal constatou-se microangiopatia cerebral caracterizada por acúmulo de material homogêneo e eosinofílico no espaço perivascular. No conteúdo intestinal, colônias com bastonetes morfológica e bioquimicamente sugestivos de Clostridium perfringens foram caracterizadas no estudo bacteriológico. A soroneutralização em camundongos com conteúdo intestinal dos animais afetados, revelou a presença da toxina épsilon. Estes achados evidenciam a enterotoxemia como doença de importância para criação de caprinos no Rio Grande do Sul.Five outbreaks of caprine enterotoxaemia in Rio Grande do Sul, Brazil, were studied. The animals were found dead or had a clinical course that usually lasted 2-3 hours. From two farms a clinical manifestation period of 12 hours was reported. Clinical signs were characterized by depression, marked abdominal discomfort, profuse watery diarrhea with fibrin clots, and death. Thirteen necropsies were performed and hydropericardium, hydrothorax and hydroperitoneum were commonly found. The mucosa and serosa of the colon were congested, and its contents was watery with multiple fibrin clots. Serosal hemorrhages and fibrin clots in the gallbladder were also seen. Fibrinous colitis and thyphilitis were the most frequent histological changes. Cerebral microangiopathy was observed in one case, which was

  20. Data Challenges

    CERN Multimedia

    McCubbin, N A

    Some two years ago we planned a series of Data Challenges starting at the end of 2001. At the time, that seemed to be comfortingly far in the future... Well, as the saying goes, doesn't time fly when you are having fun! ATLAS Computing is now deep in the throes of getting the first Data Challenge (DC0) up and running. One of the main aims of DC0 is to have a software 'release' in which we can generate full physics events, track all particles through the detector, simulate the detector response, reconstruct the event, and study it, with appropriate data storage en route. As all software is "always 95% ready" (!), we have been able to do most of this, more or less, for some time. But DC0 forces us to have everything working, together, at the same time: a reality check. DC0 should finish early next year, and it will be followed almost immediately afterwards by DC1 (DC0 was foreseen as the 'check' for DC1). DC1 will last into the middle of 2002, and has two major goals. The first is generation, simulation, and r...

  1. Coral associations of the Pleistocene Ironshore Formation, Grand Cayman

    Science.gov (United States)

    Hunter, I. G.; Jones, B.

    1996-11-01

    The 125-ka sea level, which was approximately 6 m above present-day sea level, led to the partial flooding of many Caribbean islands. On Grand. Cayman, this event led to the formation of the large Ironshore Lagoon that covered most of the western half of the island and numerous, small embayments along the south, east, and north coasts. At that time, at least 33 coral species grew in waters around Grand Cayman. This fauna, like the modern coral fauna of Grand Cayman, was dominated by Montastrea annularis, Porites porites, Acropora polmata, and A. cervicornis. Scolymia cubensis and Mycetophyllia ferox, not previously identified from the Late Pleistocene, are found in the Pleistocene patch reefs. Madracis mirabilis, Colpophyllia breviserialis, Agaricia tenuifolia, A. lamarcki, A. undata, Millepora spp., Mycetophyllia reesi, M. aliciae, and M. danaana, found on modern reefs, have not been identified from the Late Pleistocene reefs. Conversely, Pocillopora sp. cf. P. palmata, which is found in Late Pleistocene reefs, is absent on the modern reefs around Grand Cayman. The corals in the Ironshore Formation of Grand Cayman have been divided into 10 associations according to their dominant species, overall composition, and faunal diversity. Many of these associations are similar to the modern associations around Grand Cayman. Each of the Pleistocene coral associations, which can be accurately located on the known Late Pleistocene paleogeography of Grand Cayman, developed in distinct environmental settings. Overall trends identified in the modern settings are also apparent in the Late Pleistocene faunas. Thus, the diversity of the coral faunas increased from the interior of the Ironshore Lagoon to the reef crest. Similarly, the coral diversity in the Pleistocene patch reefs was related to the size of the reefs and their position relative to breaks in the barrier reef. The barrier reef included corals that are incapable of sediment rejection; whereas the patch reefs lacked

  2. Chemical Contamination of the Lower Rio Grande near Laredo, TX

    Science.gov (United States)

    Flores, B.; Ren, J.; Krishnamurthy, S.; Belzer, W.

    2006-12-01

    The Rio Grande River stretches over 2000 miles from the southern Rocky Mountains in Colorado to the tip of Texas where the Rio Grande meets the Gulf of Mexico. It is the natural boundary between U.S. and Mexico from El Paso, TX, to Brownsville, TX. The communities along the border heavily rely upon the Rio Grande as a primary source of water for consumption, agricultural uses, supporting wildlife and recreation. For many years the Rio Grande has been polluted with municipal, industrial, agricultural and farming contaminants from both sides of the border. This pollution has led to the extinction or reduction of certain wildlife species as well as affecting the health of the residences along the border. Even though great strides have been made in monitoring the Rio Grande, there has been a lack of intense monitoring data collection for pollutants such as pesticides. Three sampling sites including Manadas Creek, the Rio Grande River at International Bridge I, and USGS monitoring site 08459200 off of Highway 83 were chosen. The water quality parameters focused include temperature, pH, conductivity, dissolve oxygen (DO), salinity, total dissolved solids, nutrients, metals and pesticides. Preliminary results have shown elevated concentration of total phosphorus and ortho-phosphorus in the Manadas Creek site. Organochlorinated pesticides such as heptachlor and 4, 4 DDE were detected at various concentrations at all sites and endrin aldehyde was found at Manadas Creek site. This research has provided more information on the current chemical contamination level of the Rio Grande in the Laredo area.

  3. Perspective: A grand challenge to academic medicine: speak out on gay rights.

    Science.gov (United States)

    Dohrenwend, Anne

    2009-06-01

    Social responsibility, a dearly held value in the medical community, requires that medicine use its influence to end discrimination and to reduce barriers that affect access to care. Although the gay, lesbian, bisexual, and transgender (GLBT) population has been identified as suffering from health care disparities and oppression, the medical community and its affiliated organizations have done little to lobby in defense of the GLBT population. And with regard to the specific issue of gay marriage, medicine has yet to raise its voice in that debate, even if only to correct unscientific, capricious, and slanderous depictions of GLBT relationships. Closer to home, in medical schools and residencies, GLBT faculty and students are not provided with a safe and equal environment in which to work and learn. No credentialing provisions require residencies and their affiliate hospitals to include GLBT status in their nondiscrimination policies or to offer GLBT faculty and residents equal benefits. There is no assurance that those in power at peer-reviewed journals will use reviewers who are familiar with the research on sexual minorities to review manuscripts on GLBT topics, a situation that likely contributes to the community's status as an understudied population. Medicine cannot fulfill its obligation to GLBT patients, students, and faculty without a considerable and determined commitment to change. Some of the suggested remedies would require amending policy at the level of the Accreditation Council for Graduate Medical Education and the Association of American Medical Colleges.

  4. On the added value of forensic science and grand innovation challenges for the forensic community

    NARCIS (Netherlands)

    van Asten, A.C.

    2014-01-01

    In this paper the insights and results are presented of a long term and ongoing improvement effort within the Netherlands Forensic Institute (NFI) to establish a valuable innovation programme. From the overall perspective of the role and use of forensic science in the criminal justice system, the co

  5. New Grand Challenge for Multimedia Information Retrieval: Bridging the Utility Gap

    NARCIS (Netherlands)

    Hanjalic, A.

    2012-01-01

    This is the author-created version of the article. The needs and expectations regarding multimedia content access have grown rapidly with the fast development of multimedia technology and the explosion of multimedia content around us. This imposed high demands on the level of sophistication of mult

  6. The American Academy of Social Work and Social Welfare: History and Grand Challenges

    Science.gov (United States)

    Barth, Richard P.; Gilmore, Grover C.; Flynn, Marilyn S.; Fraser, Mark W.; Brekke, John S.

    2014-01-01

    Conceptualized by social work deans and actualized with the support of major social work organizations, the American Academy of Social Work and Social Welfare was established in 2009. This article describes the historical context and creation of the Academy, whose objectives include recognizing outstanding social work scholars and practitioners;…

  7. Ocean and climate sciences taking grand challenges and extraordinary opportunities: introduction to COAA 2007 special sections

    Institute of Scientific and Technical Information of China (English)

    ZHENG Quanan; QIAO Fangli; YANG Shi-Keng

    2008-01-01

    @@ In this universe, the earth is a unique breeding ground for living beings. It bares the evolutions, sustains the survival and enriches the development of human species. The studies of history have indicated that minute changes of the earth's environment mayhave caused great impacts on the vulnerable balanced ecological systems, endanger the living conditions for human beings and associated cultures.Thus, understanding the nature's governing rules of the earth, and clarifying its fundamental laws of sciences are everlasting research topics for the human pursuits.

  8. FY 1992 Blue Book: Grand Challenges: High Performance Computing and Communications

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — High performance computing and computer communications networks are becoming increasingly important to scientific advancement, economic competition, and national...

  9. Preventing Schizophrenia and Severe Mental Illness: A Grand Challenge for Social Work

    Science.gov (United States)

    DeVylder, Jordan E.

    2016-01-01

    Schizophrenia is a leading cause of disability and health expenditure worldwide and is associated with homelessness, substance use, familial and social isolation, unemployment, involvement with the criminal justice system, stigma, and excess mortality. Prevention may be feasible through intervention with help-seeking "clinical high-risk"…

  10. 75 FR 5634 - Grand Challenges of the 21st Century; Request for Information

    Science.gov (United States)

    2010-02-03

    ... outlines the Administration's plans to foster innovation for sustainable growth and the creation of high... decade is out, of landing a man on the moon and returning him safely to the Earth.'' More recently, in... water, engineering better medicines, securing cyberspace, and restoring and improving...

  11. Grand Challenges: Science, Engineering, and Societal Advances, Requiring Networking and Information Technology Research and Development

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — ...the U.S. Government makes critical decisions about appropriate investments in IT R and D to help society forward both socially and economically. To inform that...

  12. Taking care of our health: research tackling Europe's grand challenge of future health issues

    NARCIS (Netherlands)

    Chivot, E.; Gehem, M.; Lingemann, S.

    2012-01-01

    Europeans have never been healthier than they are today. Yet although European countries have experienced a continuous improvement of their overall health situation, our increasing wealth has paradoxically become a driving force of new health problems. Aging and unhealthy lifestyles are leading to n

  13. Research misconduct: a grand global challenge for the 21st Century.

    Science.gov (United States)

    Farthing, Michael J G

    2014-03-01

    Research misconduct is now acknowledged to be an important global issue for both researchers and the wider community. Guidance on the responsible conduct of research is now widespread, but many are still concerned by the apparent rising tide of serious cases of research misconduct, and perhaps the more worrying widespread presence of questionable research practices. I would suggest that guidance and training, while essential, are not sufficient. Additional interventions, including enhanced monitoring of research outputs and random audit using the available technology should be considered, as should the desirability of having a register of "licensed researchers." In addition, I would support a culture change in the research community in which researchers are encouraged to admit their mistakes; this should be accompanied by a spirit of forgiveness and programmed rehabilitation for the individual concerned. For multiple "premier league" offenders who are reluctant to face their misdemeanors, it is difficult to see how they could continue in the role of a researcher, and their "registration" should be revoked. Research is increasingly undertaken by researchers who cross national boundaries. The globalization of research demands greater collaboration between organizations that are responsible for ensuring standards of research integrity; the need for international standards and guidance has never been greater.

  14. FY 1993 Blue Book: Grand Challenges 1993: High Performance Computing and Communications

    Data.gov (United States)

    Networking and Information Technology Research and Development, Executive Office of the President — High performance computing and computer communications networks are becoming increasingly important to scientific advancement, economic competition, and national...

  15. SPS Challenges

    CERN Document Server

    Chapochnikova, Elena

    2008-01-01

    In future the SPS should be able to transfer to the LHC the beam produced by a completely new pre-injector chain and required by the LHC for different upgrade scenarios. The issues related to this extremely challenging task are presented together with some possible ways of overcoming the problems that arise. Besides an increase in injection energy provided by PS2, these measures can include both an SPS vacuum chamber upgrade against the e-cloud and operation with larger longitudinal emittance for beam stability. As a result the power plant of the SPS RF system must be doubled. The SPS upgrade will also need the improvement or replacement of many other machine elements.

  16. Scrapheap Challenge

    CERN Document Server

    2004-01-01

    Three British guys at CERN recently took a break from work to try their hand at Scrapheap Challenge. Shown on Channel 4 in the UK, it is a show where two teams must construct a machine for a specific task using only the junk they can scavenge from the scrap yard around them. And they have just 10 hours to build their contraption before it is put to the test. The first round, aired 19 September, pitted a team of three women, from the British Army's Royal Electrical and Mechanical Engineers, against the CERN guys - the Up 'n Atoms: Ali Day, David McFarlane and James Ridewood. Each team, with the help of an appointed expert, had the task of making a giant, 3-metre self-propelled "bowling ball", to roll down a 50 metre bowling alley at skittles 4 metres high. The Up 'n Atoms' contraption featured a small car with a huge wheel on its back. Once up to speed, slamming on the brakes caused the wheel to roll over and take the car with it. On their very last run they managed to take out seven pins. Luckily, though, ...

  17. Biomechanical analysis technique choreographic movements (for example, "grand battman jete"

    Directory of Open Access Journals (Sweden)

    Batieieva N.P.

    2015-04-01

    Full Text Available Purpose : biomechanical analysis of the execution of choreographic movement "grand battman jete". Material : the study involved students (n = 7 of the department of classical choreography faculty of choreography. Results : biomechanical analysis of choreographic movement "grand battman jete" (classic exercise, obtained kinematic characteristics (path, velocity, acceleration, force of the center of mass (CM bio parts of the body artist (foot, shin, thigh. Built bio kinematic model (phase. The energy characteristics - mechanical work and kinetic energy units legs when performing choreographic movement "grand battman jete". Conclusions : It was found that the ability of an athlete and coach-choreographer analyze the biomechanics of movement has a positive effect on the improvement of choreographic training of qualified athletes in gymnastics (sport, art, figure skating and dance sports.

  18. Grand Canal:Jiaxing in Action for World Heritage Listing

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    Editor’s Note: cities along the Grand Canal of China are working together to apply for a world heritage status for the world’s longest man-made waterway. Jiaxing in northern Zhejiang is in the league of cities for this grand mission. Two spots and six water-ways of Jiaxing are to go into the joint application. The author of this feature story is a journalist with Jiaxing Daily. From 2009 to 2011, he traveled all the way from Hangzhou to Beijing. For over two and half a year, he covered all the sections of the canal and cultural heritages, experienced local customs and lifestyles, interviewed 100 masters designated as inheritors of intangible cultural heritages. The following is a brief account of the Jiaxing section of the Grand Canal.

  19. Connection between solar activity cycles and grand minima generation

    Science.gov (United States)

    Vecchio, A.; Lepreti, F.; Laurenza, M.; Alberti, T.; Carbone, V.

    2017-03-01

    Aims: The revised dataset of sunspot and group numbers (released by WDC-SILSO) and the sunspot number reconstruction based on dendrochronologically dated radiocarbon concentrations have been analyzed to provide a deeper characterization of the solar activity main periodicities and to investigate the role of the Gleissberg and Suess cycles in the grand minima occurrence. Methods: Empirical mode decomposition (EMD) has been used to isolate the time behavior of the different solar activity periodicities. A general consistency among the results from all the analyzed datasets verifies the reliability of the EMD approach. Results: The analysis on the revised sunspot data indicates that the highest energy content is associated with the Schwabe cycle. In correspondence with the grand minima (Maunder and Dalton), the frequency of this cycle changes to longer timescales of 14 yr. The Gleissberg and Suess cycles, with timescales of 60-120 yr and 200-300 yr, respectively, represent the most energetic contribution to sunspot number reconstruction records and are both found to be characterized by multiple scales of oscillation. The grand minima generation and the origin of the two expected distinct types of grand minima, Maunder and longer Spörer-like, are naturally explained through the EMD approach. We found that the grand minima sequence is produced by the coupling between Gleissberg and Suess cycles, the latter being responsible for the most intense and longest Spörer-like minima (with typical duration longer than 80 yr). Finally, we identified a non-solar component, characterized by a very long scale oscillation of 7000 yr, and the Hallstatt cycle ( 2000 yr), likely due to the solar activity. Conclusions: These results provide new observational constraints on the properties of the solar cycle periodicities, the grand minima generation, and thus the long-term behavior of the solar dynamo.

  20. The Grand Geochemistry of 4 Vesta: First Results

    Science.gov (United States)

    Prettyman, T. H.; Beck, A.; Feldman, W. C.; Forni, O.; Joy, S. P.; Lawrence, D. J.; McCoy T. J.; McFadden, L. A.; McSween, H. Y.; Mittlefehldt, D. W.; Polanskey, C. A.; Rayman, M. D.; Raymond, C. A.; Reedy, R. C.; Russell, C. T.; Titus, T. N.; Toplis, M. J.; Yamashita, N.

    2012-01-01

    On 12-Dec-2011, the Dawn spacecraft commenced low altitude mapping of the giant asteroid, 4 Vesta (264-km mean radius). Dawn's roughly circular, polar, low altitude mapping orbit (LAMO) has a mean radius of 470 km, placing the spacecraft within about 210 km of Vesta's surface. At these altitudes, Dawn s Gamma Ray and Neutron Detector (GRaND) is sensitive to Vesta's elemental com-position (Fig. 1). GRaND will acquire data in LAMO for up to 16 weeks, which is sufficient to map the elemental composition of the entire surface of Vesta. The timing of LAMO enables us to report the first results of our geochemistry investigation at this conference. In this abstract, we present an overview of our initial observations, based on data acquired at high altitude and during the first weeks of LAMO. GRaND overview. A detailed description of the GRaND instrument, science objectives and prospective results is given in [1]. At low altitudes, GRaND is sensitive to gamma rays and neutrons produced by cosmogenic nuclear reactions and radioactive decay occurring within the top few decimeters of the surface and on a spatial scale of a few hundred kilometers. From these nuclear emissions, the abundance of several major- and minor-elements, such as Fe, Mg, Si, K, and Th can be determined. Assuming the howardite, eucrite, and diogenite (HED) meteorites are representative of Vesta s crustal composition [2], then GRaND will be able to map the mixing ratios of whole-rock HED end-members, enabling the determination of the relative proportions of basaltic eucrite, cumulate eucrite, and diogenite as well as the proportions of mafic and plagioclase minerals [1,3]. GRaND will also search for compositions not well-represented in the meteorite collection, such as evolved, K-rich lithologies [4], and outcrops of olivine from Vesta s mantle or igneous intrusions in major impact basins [5]. The search for a possible mesosiderite source region is described in [6]. GRaND will globally map the abundance of

  1. A World of Love 2008 Music Grand Ceremony

    Institute of Scientific and Technical Information of China (English)

    Bai; Yifeng

    2008-01-01

      Under the guidance of the theme slogan of the 29th Olympic Games - One World One Dream, with dream, love and dedication as its theme, the 2008 Music Grand Ceremony & 1000 People Charity Concert on 100 days countdown to Paralympic Games is officially launched on December 22, 2007. The 2008 Music Grand Ceremony is sponsored by China Disabled Persons' Federation, and co-hosted by National Paralympic Committee of China, China Huaxia Culture Group and Beijing Hanbohongyuan Culture Development Co., Ltd., aiming at supporting Chinese paralympic delegation in the 2008 Paralympic Games.……

  2. A World of Love 2008 Music Grand Ceremony

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Under the guidance of the theme slogan of the 29th Olympic Games - One World One Dream, with dream, love and dedication as its theme, the 2008 Music Grand Ceremony & 1000 People Charity Concert on 100 days countdown to Paralympic Games is officially launched on December 22, 2007. The 2008 Music Grand Ceremony is sponsored by China Disabled Persons' Federation, and co-hosted by National Paralympic Committee of China, China Huaxia Culture Group and Beijing Hanbohongyuan Culture Development Co., Ltd., aiming at supporting Chinese paralympic delegation in the 2008 Paralympic Games.

  3. Prigionieri dimenticati. Italiani nei lager della Grande guerra

    Directory of Open Access Journals (Sweden)

    Andrea Montanari

    2013-10-01

    Full Text Available L’articolo tratta del ciclo di eventi “Prigionieri dimenticati. Italiani nei lager della Grande guerra”, allestiti a Bibbiano (Reggio Emilia dal 15 al 29 settembre 2013. La prigionia nel campo di Celle (Germania è al centro di: una mostra, composta da pannelli esplicativi e oggetti provenienti dai lager e dalle trincee; uno spettacolo teatrale intitolato “Sandrone soldato”, scritto proprio a Celle; e un concerto di musiche originali composte e cantate nei lager e nelle trincee. La Grande guerra, dunque, raccontata in modo del tutto originale.

  4. Noncommutative geometry, Grand Symmetry and twisted spectral triple

    CERN Document Server

    Devastato, Agostino

    2015-01-01

    In the noncommutative geometry approach to the standard model we discuss the possibility to derive the extra scalar field sv- initially suggested by particle physicist to stabilize the electroweak vacuum - from a "grand algebra" that contains the usual standard model algebra. We introduce the Connes-Moscovici twisted spectral triples for the Grand Symmetry model, to cure a technical problem, that is the appearance, together with the field sv, of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking making the computation of the Higgs mass compatible with the 126 GeV experimental value.

  5. Noncommutative geometry, Grand Symmetry and twisted spectral triple

    Science.gov (United States)

    Devastato, Agostino

    2015-08-01

    In the noncommutative geometry approach to the standard model we discuss the possibility to derive the extra scalar field sv - initially suggested by particle physicist to stabilize the electroweak vacuum - from a “grand algebra” that contains the usual standard model algebra. We introduce the Connes-Moscovici twisted spectral triples for the Grand Symmetry model, to cure a technical problem, that is the appearance, together with the field sv, of unbounded vectorial terms. The twist makes these terms bounded, and also permits to understand the breaking making the computation of the Higgs mass compatible with the 126 GeV experimental value.

  6. Grand Symmetry, Spectral Action, and the Higgs mass

    CERN Document Server

    Devastato, Agostino; Martinetti, Pierre

    2013-01-01

    In the context of the spectral action and noncommutative geometry approach to the standard model, we build a model based on a larger symmetry. This symmetry satisfies all the conditions to have a noncommutative manifold, and mixes gauge and spin degrees of freedom and does not introduce extra fermions. With this "grand symmetry" it is natural to have the scalar field necessary to obtain the Higgs mass in the vicinity of 126 GeV. The spectral action breaks the grand symmetry to the standard model algebra. This breaking also gives the spin structure of spacetime as broken symmetry.

  7. La grande vitesse est-elle toujours sur les rails ?

    OpenAIRE

    Libourel, Eloïse; Ruggeri, Charlotte; Schorung, Matthieu

    2016-01-01

    National audience; Depuis le milieu du XXème, la grande vitesse ferroviaire est considérée comme une innovation révolutionnaire pour le transport de voyageurs. Elle renvoie une image de modernité à tous les acteurs institutionnels et à la société civile, et elle permet également aux États d’afficher une image de puissance technique et industrielle. L’objectif est de capitaliser sur l’objet « grande vitesse » pour valoriser l’avancée technologique d’un pays, d’une région, et pour promouvoir de...

  8. The Air-Shower Experiment KASCADE-Grande

    Energy Technology Data Exchange (ETDEWEB)

    Haungs, A., E-mail: haungs@ik.fzk.d [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Apel, W.D. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Arteaga, J.C. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Badea, F.; Bekk, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Bertaina, M. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Bluemer, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Bozdog, H. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, P.O. Box Mg-6, RO-7690 Bucharest (Romania); Brueggemann, M.; Buchholz, P. [Fachbereich Physik, Universitaet Siegen, 57068 Siegen (Germany); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF, 10133 Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Daumiller, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Souza, V. de [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Di Pierro, F. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Doll, P.; Engel, R.; Engler, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany)

    2009-12-15

    KASCADE-Grande is an extensive air shower experiment at the Forschungszentrum Karlsruhe, Germany. Main parts of the experiment are the Grande array spread over an area of 700x700m{sup 2}, the original KASCADE array covering 200x200m{sup 2} with unshielded and shielded detectors, and additional muon tracking devices. This multi-detector system allows to investigate the energy spectrum, composition, and anisotropies of cosmic rays in the energy range up to 1 EeV. An overview on the performance of the apparatus and first results will be given.

  9. Mercury and selenium accumulation in the Colorado River food web, Grand Canyon, USA.

    Science.gov (United States)

    Walters, David M; Rosi-Marshall, Emma; Kennedy, Theodore A; Cross, Wyatt F; Baxter, Colden V

    2015-10-01

    Mercury (Hg) and selenium (Se) biomagnify in aquatic food webs and are toxic to fish and wildlife. The authors measured Hg and Se in organic matter, invertebrates, and fishes in the Colorado River food web at sites spanning 387 river km downstream of Glen Canyon Dam (AZ, USA). Concentrations were relatively high among sites compared with other large rivers (mean wet wt for 6 fishes was 0.17-1.59 μg g(-1) Hg and 1.35-2.65 μg g(-1) Se), but consistent longitudinal patterns in Hg or Se concentrations relative to the dam were lacking. Mercury increased (slope = 0.147) with δ(15) N, a metric of trophic position, indicating biomagnification similar to that observed in other freshwater systems. Organisms regularly exceeded exposure risk thresholds for wildlife and humans (6-100% and 56-100% of samples for Hg and Se, respectfully, among risk thresholds). In the Colorado River, Grand Canyon, Hg and Se concentrations pose exposure risks for fish, wildlife, and humans, and the findings of the present study add to a growing body of evidence showing that remote ecosystems are vulnerable to long-range transport and subsequent bioaccumulation of contaminants. Management of exposure risks in Grand Canyon will remain a challenge, as sources and transport mechanisms of Hg and Se extend far beyond park boundaries.

  10. A Grand {Delta}(96) Multiplication-Sign SU(5) Flavour Model

    Energy Technology Data Exchange (ETDEWEB)

    King, Stephen F., E-mail: king@soton.ac.uk [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom); Luhn, Christoph, E-mail: christoph.luhn@durham.ac.uk [Institute for Particle Physics Phenomenology, University of Durham, Durham, DH1 3LE (United Kingdom); Stuart, Alexander J., E-mail: a.stuart@soton.ac.uk [School of Physics and Astronomy, University of Southampton, Southampton, SO17 1BJ (United Kingdom)

    2013-02-11

    Recent results from the Daya Bay and RENO reactor experiments have measured the smallest lepton mixing angle and found it to have a value of {theta}{sub 13} Almost-Equal-To 9 Degree-Sign . This result presents a new challenge for the existing paradigms of discrete flavour symmetries which attempt to describe all quark and lepton masses and mixing angles. Here we propose a Supersymmetric Grand Unified Theory of Flavour based on {Delta}(96) Multiplication-Sign SU(5), together with a U(1) Multiplication-Sign Z{sub 3} symmetry, including a full discussion of {Delta}(96) in a convenient basis. The Grand {Delta}(96) Multiplication-Sign SU(5) Flavour Model relates the quark mixing angles and masses in the form of the Gatto-Sartori-Tonin relation and realises the Georgi-Jarlskog mass relations between the charged leptons and down-type quarks. We predict a Bi-trimaximal (not Tri-bimaximal) form of neutrino mixing matrix, which, after including charged lepton corrections with zero phase, leads to the following GUT scale predictions for the atmospheric, solar, and reactor mixing angles: {theta}{sub 23} Almost-Equal-To 36.9 Degree-Sign , {theta}{sub 12} Almost-Equal-To 32.7 Degree-Sign and {theta}{sub 13} Almost-Equal-To 9.6 Degree-Sign , in good agreement with recent global fits, and a zero Dirac CP phase {delta} Almost-Equal-To 0.

  11. Mercury and selenium accumulation in the Colorado River food web, Grand Canyon, USA

    Science.gov (United States)

    Walters, David M.; E.J. Rosi-Marshall,; Kennedy, Theodore A.; W.F. Cross,; C.V. Baxter,

    2015-01-01

    Mercury (Hg) and selenium (Se) biomagnify in aquatic food webs and are toxic to fish and wildlife. The authors measured Hg and Se in organic matter, invertebrates, and fishes in the Colorado River food web at sites spanning 387 river km downstream of Glen Canyon Dam (AZ, USA). Concentrations were relatively high among sites compared with other large rivers (mean wet wt for 6 fishes was 0.17–1.59 μg g–1 Hg and 1.35–2.65 μg g–1 Se), but consistent longitudinal patterns in Hg or Se concentrations relative to the dam were lacking. Mercury increased (slope = 0.147) with δ15N, a metric of trophic position, indicating biomagnification similar to that observed in other freshwater systems. Organisms regularly exceeded exposure risk thresholds for wildlife and humans (6–100% and 56–100% of samples for Hg and Se, respectfully, among risk thresholds). In the Colorado River, Grand Canyon, Hg and Se concentrations pose exposure risks for fish, wildlife, and humans, and the findings of the present study add to a growing body of evidence showing that remote ecosystems are vulnerable to long-range transport and subsequent bioaccumulation of contaminants. Management of exposure risks in Grand Canyon will remain a challenge, as sources and transport mechanisms of Hg and Se extend far beyond park boundaries. Environ Toxicol Chem2015;9999:1–10

  12. Regulatory challenges

    Energy Technology Data Exchange (ETDEWEB)

    Austvik, Ole Gunnar

    2003-07-01

    The problem for policy makers wanting to liberalize natural gas markets is that its concentrated structure may also be the socially most efficient one. Because of scale economies, more firms operating in the market may incur higher transportation costs unless the market grows sufficiently in each geographic segment. This argument goes for product extension through vertical (or horizontal) integration and the exploitation of economies of scope as well. Thus, the challenge for governments is to intervene in a way that preserves a market structure that has the potential to minimize cost, and at the same lime change its behavior in order to avoid possible lax cost control and exploitation of market power. The existence of scope advantages indicates that liberalization of the market should open for the possibility to bundle services in competition with provision of unbundled services. If operations are unbundled and there exist economies of scope, the gain from increased competition should be weighed against the losses of less efficient operations of each firm. Thus, with the growth in the European market, gradually more arguments support the idea of unbundling. The significant scale economy in trunk pipelines, sunk investments and capital immobility, possible economies of scope in vertical integration and companies' bundling of services influences vertical and horizontal ownership relations and contractual terms in the European gas market. In specific segments of the markets, these relationships may promote efficient investments and pricing without public interference, but the strong concentration of market power indicates that this is rather the exception than the rule. In order to design an efficient and welfare maximizing way of regulating the market one needs a closer identification of the actual goal of the regulation. Microeconomic theory is often used for this purpose. The author discusses the alternatives of laissez-faire, nationalization or regulation for

  13. Bacteriophages as anti-infective agents: recent developments and regulatory challenges.

    Science.gov (United States)

    Gilmore, Brendan F

    2012-05-01

    The biennial meeting on 'Exploiting Bacteriophages for Bioscience, Biotechnology and Medicine', held in London, UK, on 20 January 2012, and chaired by George Salmond (University of Cambridge, UK) hosted over 50 participants representing 13 countries. The highly multidisciplinary meeting covered a diverse range of topics, reflecting the current expansion of interest in this field, including the use of bacteriophages as the source of biochemical reagents for molecular biology, bacteriophages for the treatment of human and animal diseases, bacteriophage-based diagnostics and therapeutic delivery technologies and necessity for, and regulatory challenges associated with, robust clinical trials of phage-based therapeutics. This report focuses on a number of presentations from the meeting relating to cutting-edge research on bacteriophages as anti-infective agents.

  14. Guest editorial: governing the challenges of climate change and energy transition in cities

    OpenAIRE

    Hoppe, T; Van Bueren, E.M.

    2015-01-01

    Cities form the key context within which social, economic and environmental challenges for sustainable development will manifest in the years to come. As they face the grand societal challenges of climate change and the greening of energy systems, city governments are confronted with the challenge of designing and implementing workable policy strategies. We find that although much attention has been paid to low carbon energy transition in cities, there is surprisingly little attention to the ...

  15. NewsMars: Express journey to Mars ASE 2003: Knocked out by meteorites Events: Sun-Earth Day ASE 2003: Fun Physics - popular as ever Appointments: Sykes to bring science to the people UK Science Education: The future's bright, the future's science ASE 2003: A grand finale for Catherine Teaching Resources: UK goes to the planets Cambridge Physics Update: Basement physics Conferences: Earth Science Teachers' Association Conference 2003 New Website: JESEI sets sail GIREP: Teacher education seminar Malaysia: Rewards for curriculum change Cambridge Physics Update: My boomerang will come back! Teaching Resources: Widening particiption through ideas and evidence with the University of Surrey Wales: First Ffiseg Events: Nuna: Solar car on tour Physics on Stage: Physics on Stage 3 embraces life Symposium: In what sense a nuclear 'debate'? Gifted and Talented: Able pupils experiencing challenging science Australia: ISS flies high Down Under

    Science.gov (United States)

    2003-03-01

    Mars: Express journey to Mars ASE 2003: Knocked out by meteorites Events: Sun-Earth Day ASE 2003: Fun Physics - popular as ever Appointments: Sykes to bring science to the people UK Science Education: The future's bright, the future's science ASE 2003: A grand finale for Catherine Teaching Resources: UK goes to the planets Cambridge Physics Update: Basement physics Conferences: Earth Science Teachers' Association Conference 2003 New Website: JESEI sets sail GIREP: Teacher education seminar Malaysia: Rewards for curriculum change Cambridge Physics Update: My boomerang will come back! Teaching Resources: Widening particiption through ideas and evidence with the University of Surrey Wales: First Ffiseg Events: Nuna: Solar car on tour Physics on Stage: Physics on Stage 3 embraces life Symposium: In what sense a nuclear 'debate'? Gifted and Talented: Able pupils experiencing challenging science Australia: ISS flies high Down Under

  16. Accidental permutation symmetries as a test for Grand Unification: the supersymmetric $SU(5)$ case

    CERN Document Server

    Fichet, Sylvain

    2016-01-01

    Unification of matter fields implies the existence of accidental permutation symmetries, which potentially remain immune to large quantum corrections up to the TeV scale. We investigate the case of a supersymmetric $SU(5)$ grand unified theory, where such a permutation symmetry is present in the up-type squark sector. We present a variety of tests allowing to challenge the $SU(5)$ hypothesis based on the observation of squarks at the LHC. These tests appear as relations among observables involving flavour-violating or chirality-flipping decays of squarks. Moreover, they rely on top-polarimetry and charm-tagging. As an example, we discuss the application to the scenario of Natural Supersymmetry, while more examples can be found in the related journal publications.

  17. The spectrum of high-energy cosmic rays measured with KASCADE-Grande

    CERN Document Server

    Apel, W D; Bekk, K; Bertaina, M; Bluemer, J; Bozdog, H; Brancus, I M; Buchholz, P; Cantoni, E; Chiavassa, A; Cossavella, F; Daumiller, K; de Souza, V; Di Pierro, F; Doll, P; Engel, R; Engler, J; Finger, M; Fuhrmann, D; Ghia, P L; Gils, H J; Glasstetter, R; Grupen, C; Haungs, A; Heck, D; Hoerandel, J R; Huber, D; Huege, T; Kampert, K -H; Kang, D; Kickelbick, D; Klages, H O; Link, K; Luczak, P; Ludwig, M; Mathes, H J; Mayer, H J; Melissas, M; Milke, J; Mitrica, B; Morello, C; Navarra, G; Oehlschlaeger, J; Ostapchenko, S; Over, S; Palmieri, N; Petcu, M; Pierog, T; Rebel, H; Roth, M; Schieler, H; Schroeder, F G; Sima, O; Toma, G; Trinchero, G C; Ulrich, H; Weindl, A; Wochele, J; Wommer, M; Zabierowski, J

    2012-01-01

    The energy spectrum of cosmic rays between 10**16 eV and 10**18 eV, derived from measurements of the shower size (total number of charged particles) and the total muon number of extensive air showers by the KASCADE-Grande experiment, is described. The resulting all-particle energy spectrum exhibits strong hints for a hardening of the spectrum at approximately 2x10**16 eV and a significant steepening at c. 8x10**16 eV. These observations challenge the view that the spectrum is a single power law between knee and ankle. Possible scenarios generating such features are discussed in terms of astrophysical processes that may explain the transition region from galactic to extragalactic origin of cosmic rays.

  18. An international borderland of concern: Conservation of biodiversity in the Lower Rio Grande Valley

    Science.gov (United States)

    Leslie,, David M.

    2016-07-20

    The Lower Rio Grande Valley (LRGV) of southern Texas is located on the United States-Mexico borderland and represents a 240-kilometer (150-mile) linear stretch that ends at the Gulf of Mexico. The LRGV represents a unique transition between temperate and tropical conditions and, as such, sustains an exceptionally high diversity of plants and animals—some of them found in few, or no other, places in the United States. Examples include Leopardus pardalis albescens (northern ocelot) and Falco femoralis septentrionalis (northern aplomado falcon)—both endangered in the United States and emblematic of the LRGV. The U.S. Fish and Wildlife Service (USFWS) manages three national wildlife refuges (Santa Ana, Lower Rio Grande Valley, and Laguna Atascosa) that together make up the South Texas Refuge Complex, which actively conserves biodiversity in about 76,006 hectares (187,815.5 acres) of native riparian and upland habitats in the LRGV. These diminished habitats harbor many rare, threatened, and endangered species. This report updates the widely used 1988 USFWS biological report titled “Tamaulipan Brushland of the Lower Rio Grande Valley of South Texas: Description, Human Impacts, and Management Options” by synthesizing nearly 400 peer-reviewed scientific publications that have resulted from biological and sociological research conducted specifically in the four Texas counties of the LRGV in the past nearly 30 years. This report has three goals: (1) synthesize scientific insights gained since 1988 related to the biology and management of the LRGV and its unique biota, focusing on flora and fauna of greatest conservation concern; (2) update ongoing challenges facing Federal and State agencies and organizations that focus on conservation or key natural resources in the LRGV; and (3) redefine conservation opportunities and land-acquisition strategies that are feasible and appropriate today, given the many new and expanding constraints that challenge conservation

  19. Nuove prospettive storiografiche sulla Grande guerra: violenze, traumi, esperienze

    Directory of Open Access Journals (Sweden)

    Marco Bizzocchi

    2014-03-01

    Full Text Available Il testo propone, attraverso l’analisi delle recensioni pubblicate sulla rivista internazionale “First World War Studies”, una rassegna su alcuni recenti studi storici sulla Prima guerra mondiale. Dopo la svolta degli anni Settanta-Ottanta, la storiografia sta continuando ad approfondire in particolare il tema dei risvolti sociali e culturali della Grande guerra.

  20. The Strategic Planning Process and the Need for Grand Strategy

    Science.gov (United States)

    2007-11-02

    Basil Liddell Hart defines the purpose of grand strategy as the means “to coordinate and direct all of the resources of the nation, or band of nations...University Press. Murray, William, MacGregor Knox, and Alvin Bernstein . The Making of Strategy. New York: Cambridge University Press, 1994. Naveh, Shimon

  1. Os grandes consumidores de consultas medicas: um estudo de familia

    Directory of Open Access Journals (Sweden)

    M. Pereira Graça

    2002-01-01

    Full Text Available Este artículo describe un estudio sobre algunas características familiares de sujetos grandes consumidores de servicios de salud. Por un lado, se compara un grupo de grandes consumidores de servicios de salud, a nivel de número de consultas, con un grupo control en términos de funcionamiento familiar y actitudes hacia los médicos y la Medicina; por otro lado, se estudia la relación entre la dinámica familiar y las actitudes hacia la Medicina y los médicos en el grupo de los grandes consumidores. Los resultados muestran que los dos grupos de usuarios son significativamente diferentes; además, en el grupo de grandes consumidores el funcionamiento familiar problemático parece ser un factor intermediario en el desarrollo de actitudes menos negativas hacia los médicos y la Medicina. Se discuten las implicaciones que los resultados tienen a nivel de intervención terapéutica.

  2. Progress at the La Grande complex phase II in Quebec

    Energy Technology Data Exchange (ETDEWEB)

    Levay, J.; Caron, O.; Parent, L. (Societe d' Energie de la Baie James (SEBJ), Montreal (Canada))

    1993-08-01

    Phase II of the La Grande complex in Quebec, Canada, is now under construction (see Water Power and Dam Construction January 1990 and Handbook 1993). This article gives an update on progress at the schemes that comprise the major elements of Phase II. (author)

  3. Grand Canyon Trekkers: School-Based Lunchtime Walking Program

    Science.gov (United States)

    Hawthorne, Alisa; Shaibi, Gabriel; Gance-Cleveland, Bonnie; McFall, Sarah

    2011-01-01

    The incidence of childhood overweight is especially troubling among low income Latino youth. Grand Canyon Trekkers (GCT) was implemented as a quasi-experimental study in 10 Title 1 elementary schools with a large Latino population to examine the effects of a 16-week structured walking program on components of health-related physical fitness: Body…

  4. Grande Ronde Basin Fish Habitat Enhancement Project : 1998 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Vance R.; Powell, Russ M.

    1999-05-01

    The primary goal of ''The Grande Ronde Basin Fish Habitat Improvement Project'' is to access, create, improve, protect, and restore reparian and instream habitat for anadromous salmonids, thereby maximizing opportunities for natural fish production within the basin.

  5. Winning in straight sets helps in Grand Slam tennis

    NARCIS (Netherlands)

    Goossens, Dries R.; Kempeneers, Jurgen; Koning, Ruud H.; Spieksma, Frits C. R.

    2015-01-01

    In this contribution, we study whether fatigue resulting from the previous match affects a player's chances of winning his (or her) next match in Grand Slum tennis. We measure relative fatigue levels of two opponents by looking at the difference in number of sets played in their previous match. We d

  6. Anti-Grand Unification and Critical Coupling Universality

    CERN Document Server

    Laperashvili, L V

    1997-01-01

    The present work considers the phase transition between the confinement and "Coulomb" phases in U(1), SU(2) and SU(3)-sectors of Anti-grand unified theory described by regularized Wilson loop action. It was shown the independence of the critical coupling constants of the regularization method ("universality").

  7. Los grandes retos tecnológicos de este siglo

    OpenAIRE

    Rojas Jiménez, Keilor

    2013-01-01

    El siglo anterior fue testigo del desarrollo de grandes avances tecnológicos como la electricidad, los automóviles, los cohetes, el laser, los antibióticos, las computadoras e internet. Estos ejemplos del ingenio humano permitieron que la población creciera y se interconectara como nunca antes en la historia.

  8. Carbonaceous aerosol particles from common vegetation in the Grand Canyon

    Energy Technology Data Exchange (ETDEWEB)

    Hallock, K.A.; Mazurek, M.A. (Brookhaven National Lab., Upton, NY (United States)); Cass, G.R. (California Inst. of Tech., Pasadena, CA (United States). Dept. of Environmental Engineering Science)

    1992-05-01

    The problem of visibility reduction in the Grand Canyon due to fine organic aerosol particles in the atmosphere has become an area of increased environmental concern. Aerosol particles can be derived from many emission sources. In this report, we focus on identifying organic aerosols derived from common vegetation in the Grand Canyon. These aerosols are expected to be significant contributors to the total atmospheric organic aerosol content. Aerosol samples from living vegetation were collected by resuspension of surface wax and resin components liberated from the leaves of vegetation common to areas of the Grand Canyon. The samples were analyzed using high-resolution gas chromatography/mass spectrometry (GC/MS). Probable identification of compounds was made by comparison of sample spectra with National Institute of Standards and Technology (NIST) mass spectral references and positive identification of compounds was made when possible by comparison with authentic standards as well as NIST references. Using these references, we have been able to positively identify the presence of n-alkane and n-alkanoic acid homolog series in the surface waxes of the vegetation sampled. Several monoterpenes, sesquiterpenes, and diterpenes were identified also as possible biogenic aerosols which may contribute to the total organic aerosol abundance leading to visibility reduction in the Grand Canyon.

  9. A Model for a Grand Theory: Creativity in Art.

    Science.gov (United States)

    McWhinnie, Harold J.

    This paper presents a collection of thoughts and observations about a grand theory of creativity in the arts. The theory elaborated in the paper is based upon the following five major bodies of psychological knowledge and research: (1) hemisphere differences and cerebral lateralization; (2) chemical balance in the brain and bipolar factors; (3)…

  10. Construction of calibration pads facility, Walker Field, Grand Junction, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    Ward, D.L.

    1978-08-01

    A gamma-ray spectrometer facility was completed at Walker Field Airport, Grand Junction, Colorado, in November 1976. This report describes spectrometers and their calibration, the construction of the spectrometer facility, the radioelement concentrations, procedures for using the facilites, and environmental considerations. (LK)

  11. Combined Lopes and Kascade-Grande Data Analysis

    NARCIS (Netherlands)

    Haungs, A.; Bähren, L.; Buitink, S.J.; Falcke, H.D.E.; Horneffer, K.H.A.; Kuijpers, J.M.E.; Lafebre, S.J.; Nigl, A.; Petrovic, J.

    2006-01-01

    First analyses of coincident data of the LOPES (LOfar PrototypE Station) radio antennas with the particle air shower experiment KASCADE-Grande show basic correlations in the observed shower parameters, like the strength of the radio signal and the particle number, or comparing the estimated shower d

  12. Piccolo tõi Soomest taas grand prix'

    Index Scriptorium Estoniae

    2009-01-01

    Tänavuse Lappeenrantas toimunud rahvusvahelise suupillifestivali võistumängimisel osalesid suupilliklubi Piccolo orkester, kvartett ja noored solistid. Grand prix' ehk suure võidukarika pälvis Piccolo suupillikvartett koosseisus Ilmar Tõnisson, Andrus Haugas, Andres Kokk ja Elmar Trink. Noorte kategooria võitjaks tunnistati Martin Merevits, kolmandad kohad saavutasid Janek Sildvee bluusi- ja Eduard Einmann diatoonilise suupilli kategoorias

  13. Eesti nukufilm sai järjekordse grand prix

    Index Scriptorium Estoniae

    2005-01-01

    XII Rahvusvaheline animafilmifestival "KROK-2005", mis toimus laeval, mis sõitis Kiievist Odessasse. Rao Heidmets ja Hardi Volmer said festivali karnevalil oma jänese kostüümi eest grand prix. Eesti filmidest olid programmis "Karl ja Marilyn", "Frank ja Wendy", "Barbarid", "Laud" ja "Conkistadoor"

  14. KASCADE-Grande: An overview and first results

    Energy Technology Data Exchange (ETDEWEB)

    Bertaina, M. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy)], E-mail: bertaina@to.infn.it; Apel, W.D. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Arteaga, J.C. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, 76021 Karlsruhe (Germany); Badea, F.; Bekk, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Bluemer, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, 76021 Karlsruhe (Germany); Bozdog, H. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, 7690 Bucharest (Romania); Brueggemann, M.; Buchholz, P. [Fachbereich Physik, Universitaet Siegen, 57068 Siegen (Germany); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, 76021 Karlsruhe (Germany); Daumiller, K. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Souza, V. de [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, 76021 Karlsruhe (Germany); Di Pierro, F. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Doll, P.; Engel, R.; Engler, J. [Institut fuer Kernphysik, Forschungszentrum Karlsruhe, 76021 Karlsruhe (Germany); Finger, M. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, 76021 Karlsruhe (Germany); Fuhrmann, D. [Fachbereich Physik, Universitaet Wuppertal, 42097 Wuppertal (Germany)] (and others)

    2008-04-01

    The KASCADE-Grande experiment, located at Forschungszentrum Karlsruhe (Germany), is a multi-component extensive air-shower experiment to study cosmic rays and their interactions at primary energies 10{sup 14}-10{sup 18} eV. After detailed investigations of the knee in the spectrum with KASCADE and EAS-TOP experiments, the main goal of KASCADE-Grande is to provide conclusive results on the knee region by detecting the expected iron knee in the spectrum at around 10{sup 17} eV, and measuring the composition in the possible transition region between galactic and extragalactic components. Due to its multi-component characteristics, basically the former KASCADE experiment enriched by two new arrays of scintillator detectors (Grande and Piccolo), with the aim of providing a large acceptance area (0.5 km{sup 2}) and prompt trigger signal, KASCADE-Grande is a suitable array to provide refined measurements in the 10{sup 16}-10{sup 18} eV region. In the following, we briefly report on the characteristics of the detector, its performance, and first results based on 2 years of data taking.

  15. Recent Results from KASCADE-Grande and LOPES

    Energy Technology Data Exchange (ETDEWEB)

    Kampert, K.-H., E-mail: kampert@uni-wuppertal.d [Fachbereich Physik, Universitaet Wuppertal, 42097 Wuppertal (Germany); Apel, W.D. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany); Arteaga, J.C. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Asch, T. [Inst. Prozessdatenverarb. und Elektronik, Forschungszentrum Karlsruhe, D-76021 Karlsruhe (Germany); Badea, F. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany); Baehren, L. [Dept. of Astrophysics, Radboud University Nijmegen, 6525 ED Nijmegen (Netherlands); Bekk, K. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany); Bertaina, M. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Biermann, P.L. [Max-Planck-Institut fuer Radioastronomie, 53010 Bonn (Germany); Bluemer, J. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany); Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Bozdog, H. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany); Brancus, I.M. [National Institute of Physics and Nuclear Engineering, P.O. Box Mg-6, RO-7690 Bucharest (Romania); Brueggemann, M.; Buchholz, P. [Fachbereich Physik, Universitaet Siegen, 57068 Siegen (Germany); Buitink, S. [Dept. of Astrophysics, Radboud University Nijmegen, 6525 ED Nijmegen (Netherlands); Cantoni, E. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Istituto di Fisica dello Spazio Interplanetario, INAF, 10133 Torino (Italy); Chiavassa, A. [Dipartimento di Fisica Generale dell' Universita, 10125 Torino (Italy); Cossavella, F. [Institut fuer Experimentelle Kernphysik, Universitaet Karlsruhe, D-76021 Karlsruhe (Germany); Daumiller, K. [Institut fuer Kernphysik, Forschungszentrum, Karlsruhe, D-76021 Karlsruhe (Germany)

    2009-05-15

    KASCADE-Grande is an extensive air-shower experiment located at Forschungszentrum Karlsruhe, Germany. Main parts of the experiment are the Grande array spread over an area of 700x700 m{sup 2}, the original KASCADE array covering 200x200 m{sup 2} with unshielded and shielded detectors, and additional muon tracking devices. This multi-detector system allows to investigate the energy spectrum, composition, and anisotropies of cosmic rays in the energy range up to 1 EeV. LOPES is co-located at the same site to measure radio pulses from extensive air showers in coincidence with KASCADE-Grande. It consists of 30 digital antennas operated in different geometrical configurations. Read out is performed at high bandwidths and rate data processing with the aim to calibrate the emitted signal in the primary energy range of 10{sup 16}-10{sup 18} eV by making use of reconstructed air-shower observables of KASCADE-Grande. An overview on the performance of both experiments will be given and recent analysis results be reported.

  16. Un grand homme dans le petit monde des grandes écoles

    Directory of Open Access Journals (Sweden)

    Christian Hottin

    2009-05-01

    Full Text Available La recherche publiée dans la présente livraison de In Situ s’inscrivait à l’origine dans un atelier du Lahic consacré à la construction de la figure de Pasteur comme héros scientifique. Au sein de ce programme, on s’est plus particulièrement attaché à l’étude de la représentation de Pasteur dans le monde de l’enseignement supérieur parisien. Issu de ce monde avant que d’en être devenu l’une des figures les plus illustres, Louis Pasteur fait l’objet de nombreuses figurations dans les facultés et les grandes écoles parisiennes. Présent dans une dizaine d’établissements - ce qui est rarissime, la plupart des personnages représentés ne l’étant que dans une voire deux institutions - Pasteur marque de son visage aisément reconnaissable les couloirs de la Sorbonne comme le jardin de l’École normale supérieure. Parcourir la Montagne Sainte-Geneviève à la recherche de son image renseigne aussi bien sur la figuration de cet éminent savant en héros que sur les relations entretenues, à travers lui, par les différents établissements entre eux : tout entier accaparé par les normaliens et les scientifiques, Pasteur est singulièrement absent chez les médecins, à quelques dizaines de mètres de la Sorbonne...The research published in this present issue of the electronic review In Situ results from a series of papers discussed in a workshop of the LAHIC laboratory devoted to the question of how Pasteur came to be seen as a scientific hero. Within this programme we were particularly interested in looking at how Pasteur was represented in the world of higher learning in Paris. Pasteur was very much a part of this world before becoming one of its most illustrious representatives and, as such, was the object of numerous representations in the faculties and ‘grandes écoles’ in Paris. Exceptionally, he was associated with about ten of these institutions; most of the outstanding scientific figures of his

  17. Overview of natural gas in Rio Grande do Norte, Brazil; Panorama do gas natural no Rio Grande do Norte

    Energy Technology Data Exchange (ETDEWEB)

    Teixeira, Pedro Helio Gomes [Universidade Federal do Rio Grande do Norte (GREEN/UFRN), Natal, RN (Brazil). Centro de Tecnologia. Grupo de Estudos Energeticos

    2008-07-01

    This work draws a picture of what the natural gas means to Rio Grande do Norte in its quantitative dimension, expressed in the numbers and reserve indicators, production and structure of consume. In another dimension, it broaches the processes of energetic substitution by the natural gas in the state energetic matrix. (author)

  18. Birds of the Reserva Biológica do Mato Grande and surroundings, Rio Grande do Sul, Brazil

    DEFF Research Database (Denmark)

    Vizentin-Bugoni, Jeferson; Jacobs, Fernando; Coimbra, Marco Antônio Afonso;

    2015-01-01

    The Reserva Biológica do Mato Grande encompasses 5,161 hectares of wetlands, restinga forests and grasslands in southern Brazil. Aiming to assemble a list of bird species occurring in the reserve, we carried out 21 monthly expeditions from July 2007 to March 2009 and an additional visit on October...

  19. 78 FR 11680 - Notice of Intent To Repatriate Cultural Items: Grand Rapids Public Museum, Grand Rapids, MI

    Science.gov (United States)

    2013-02-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR... Grand Rapids Public Museum from a source with the initials ``K.S.I.'' (likely Kent Scientific Institute... to the U.S. Government and traditional tribal hunting and trading routes covered a large portion...

  20. Sedimentology and stratigraphy of the Palisades, Lower Comanche, and Arroyo Grande areas of the Colorado River Corridor, Grand Canyon, Arizona

    Science.gov (United States)

    Draut, Amy E.; Rubin, David M.; Dierker, Jennifer L.; Fairley, Helen C.; Griffiths, Ronald E.; Hazel, Joseph E.; Hunter, Ralph E.; Kohl, Keith; Leap, Lisa M.; Nials, Fred L.; Topping, David J.; Yeatts, Michael

    2005-01-01

    This report analyzes various depositional environments in three archaeologically significant areas of the Colorado River corridor in Grand Canyon. Archaeological features are built on and buried by fluvial, aeolian, and locally derived sediment, representing a complex interaction between geologic and cultural history. These analyses provide a basis for determining the potential influence of Glen Canyon Dam operations on selected archaeological sites and thus for guiding dam operations in order to facilitate preservation of cultural resources. This report presents initial results of a joint effort between geologists and archaeologists to evaluate the significance of various depositional processes and environments in the prehistoric formation and modern preservation of archaeological sites along the Colorado River corridor in Grand Canyon National Park. Stratigraphic investigations of the Palisades, Lower Comanche, and Arroyo Grande areas of Grand Canyon yield detailed information regarding the sedimentary history at these locations. Reconstruction of past depositional settings is critical to a thorough understanding of the geomorphic and stratigraphic evolution of these three archaeologically significant areas. This examination of past sedimentary environments allows the relative significance of fluvial, aeolian, debris-fan, and slope-wash sedimentary deposits to be identified at each site. In general the proportion of fluvial sediment (number and thickness of flood deposits) is shown to decrease away from the river, and locally derived sediment becomes more significant. Flood sequences often occur as 'couplets' that contain a fluvial deposit overlain by an interflood unit that reflects reworking of fluvial sediment at the land surface by wind and local runoff. Archaeological features are built on and buried by sediment of various depositional environments, implying a complex interaction between geologic and cultural history. Such field analysis, which combines

  1. 78 FR 32441 - Grand Ditch Breach Restoration, Final Environmental Impact Statement, Rocky Mountain National...

    Science.gov (United States)

    2013-05-30

    ... National Park Service Grand Ditch Breach Restoration, Final Environmental Impact Statement, Rocky Mountain... Availability of the Final Environmental Impact Statement for the Grand Ditch Breach Restoration, Rocky Mountain... Grand Ditch Breach Restoration, Rocky Mountain National Park, Colorado. DATES: The National Park...

  2. 77 FR 37326 - Safety Zone; Grand Hotel 125th Anniversary Fireworks Celebration, Mackinaw Island, MI

    Science.gov (United States)

    2012-06-21

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Grand Hotel 125th Anniversary Fireworks... launched from a point on Lake Huron to commemorate the Grand Hotel's 125th anniversary. The Captain of the Port, Sector Sault Sainte Marie, has determined that the Grand Hotel Celebration Fireworks Display...

  3. Water Environment Evolution along the China Grand Canal

    Science.gov (United States)

    Mao, F.; Wu, Y. X.; Yang, B. F.; Li, X. J.

    2014-03-01

    The China Grand Canal is one of the earliest canals in the world, having lasted for nearly 3000 years. Even its section canals have a rich history, such as the North-South Grand Canal that was established during the Sui Dynasty, whereas the Beijing-Hangzhou Canal was excavated during the Yuan Dynasty and the east line of the South-to-North Water Diversion. As one of the longest in the world, the China Grand Canal's total length is over 3500 kilometers. This length includes the navigable, unnavigable, and underground sections. Making the best use of situations and according to local conditions, the Chinese people harmoniously constructed the Beijing-Hangzhou Canal with nature. Tens of millions of workers took nearly 3000 years to complete the great shipping system. Navigable sections still exist for up to 900 kilometers and the volume of freight traffic is approximately 300 million tons. The canal remains the main logistical channel of the North-to-South Coal Transportation, South-to-North Water Diversion, and resources circulation. To date, China is promoting the success of heritage application. Part of these efforts is the declaration of the China Grand Canal as a World Cultural Heritage by 2014. In addition, the east route of the South-to-North Water Transfer project is planned to be navigable by 2016. The ancient Beijing-Hangzhou Grand Canal will usher in the new ecological civilization and cultural revival along the canal. This paper presents technical methods of water environment evolution research on the river system, river, and water quality along the Beijing-Hangzhou Canal through the integration of historical literature and modern remote sensing image data. The study carried out water environment investigation and analysis along the Beijing-Hangzhou canal by using ETM, SPOT image data, and GPS measurement data. Spatial and temporal evolution characteristics and regulations of the Beijing-Hangzhou Grand Canal regional water environment in the span of 3000

  4. A Grand Vision for European Astronomy

    Science.gov (United States)

    2007-09-01

    Today, and for the first time, astronomers share their global Science Vision for European Astronomy in the next two decades. This two-year long effort by the ASTRONET network of funding agencies, sponsored by the European Commission and coordinated by INSU-CNRS, underscores Europe's ascension to world leadership in astronomy and its will to maintain that position. It will be followed in just over a year by a prioritised roadmap for the observational facilities needed to implement the Vision. Implementation of these plans will ensure that Europe fully contributes to Mankind's ever deeper understanding of the wonders of our Universe. astronet logo "This is a great opportunity to help create a vibrant long-term future for astronomy and science" says Tim de Zeeuw (Leiden Observatory, The Netherlands) who led this community-wide effort. The ASTRONET Science Vision provides a comprehensive overview of the most important scientific questions that European astronomy should address in the next twenty years. The four key questions are the extremes of the Universe, from the nature of the dark matter and dark energy that comprise over 95% of the Universe to the physics of extreme objects such as black holes, neutron stars, and gamma-ray bursts; the formation of galaxies from the first seeds to our Milky Way; the formation of stars and planets and the origin of life; and the crucial question of how do we (and our Solar System) fit in the global picture. These themes reach well beyond the realm of traditional astronomy into the frontiers of physics and biology. The Vision identifies the major new facilities that will be needed to achieve these goals, but also stresses the need for parallel developments in theory and numerical simulations, high-performance computing resources, efficient astronomical data archiving and the European Virtual Observatory, as well as in laboratory astrophysics. "This report is a key input for the even more challenging task of developing a prioritised

  5. Blaise Cendrars et ses 'Grands Fétiches'

    DEFF Research Database (Denmark)

    Doubinsky, Sebastien

    2016-01-01

    Quand l’écrivain Blaise Cendrars fait paraître sa série de poèmes réunis sous le titre Les Grands Fétiches dans la revue bruxelloise Le Disque vert en 1922, il semble participer de la grande mode « Nègre » qui secoue la France en cette période. Co-découvreur des arts dits « primitives » dès 1916...... avec Guillaume Apollinaire, l’écrivain va les insérer dans son travail poétique comme miroirs inversés de la modernité occidentale. Cependant, même s'il utilise certains des clichés racistes de son époque, il se place lui-même dans le camp des « mélanophiles », et va se servir de cet Art Nègre pour...

  6. High-energy cosmic rays measured with KASCADE-Grande

    CERN Document Server

    Haungs, A; Arteaga-Velazquez, J C; Bekk, K; Bertaina, M; Bluemer, J; Bozdog, H; Brancus, I M; Cantoni, E; Chiavassa, A; Cossavella, F; Curcio, C; Daumiller, K; de Souza, V; Di Pierro, F; Doll, P; Engel, R; Engler, J; Fuchs, B; Fuhrmann, D; Gils, H J; Glasstetter, R; Grupen, C; Heck, D; Hoerandel, J R; Huber, D; Huege, T; Kampert, K -H; Kang, D; Klages, H O; Link, K; Luczak, P; Ludwig, M; Mathes, H J; Mayer, H J; Melissas, M; Milke, J; Mitrica, B; Morello, C; Oehlschlaeger, J; Ostapchenko, S; Palmieri, N; Petcu, M; Pierog, T; Rebel, H; Roth, M; Schieler, H; Schoo, S; Schroeder, F G; Sima, O; Toma, G; Trinchero, G C; Ulrich, H; Weindl, A; Wochele, D; Wochele, J

    2013-01-01

    The detection of high-energy cosmic rays above a few hundred TeV is realized by the observation of extensive air-showers. By using the multi-detector setup of KASCADE-Grande, energy spectrum, elemental composition, and anisotropies of high-energy cosmic rays in the energy range from below the knee up to 2 EeV are investigated. In addition, the large high-quality data set permits distinct tests of the validity of hadronic interaction models used in interpreting air-shower measurements. After more than 16 years, the KASCADE-Grande experiment terminated measurements end of 2012. This contribution will give an overview of the main results of the data analysis achieved so far, and will report about the status of KCDC, the KASCADE Cosmic-ray Data Center, where via a web-based interface the data will be made available for the interested public.

  7. Trilepton Signal of Grand Unified Models at the Tevatron

    CERN Document Server

    Accomando, E; Dutta, B

    2000-01-01

    At the Tevatron, the most promising channel to detect supersymmetry is three leptons plus missing energy, where the leptons are $e$'s and/or $\\mu$'s. This final state appears from the production of chargino and second lighetst neutralino. However in grand unified models with universal scalar masses at the grand unified scale, this final state mostly consists of $\\tau$'s which are hard to detect. We show that for some regions of non universality in the scalar masses at the GUT scale based on unifying groups like SU(5) or SO(10), the final state mostly consists of 3$l$+${\\rlap/E}_T$ and $\\tau ll$+${\\rlap/E}_T$. The first mode has very high detection efficiency and the second one is expected to have high detection efficency as well. We also show that these models can have enough events in these modes to be detected in RUN II.

  8. Clinical Immersion and Biomedical Engineering Design Education: "Engineering Grand Rounds".

    Science.gov (United States)

    Walker, Matthew; Churchwell, André L

    2016-03-01

    Grand Rounds is a ritual of medical education and inpatient care comprised of presenting the medical problems and treatment of a patient to an audience of physicians, residents, and medical students. Traditionally, the patient would be in attendance for the presentation and would answer questions. Grand Rounds has evolved considerably over the years with most sessions being didactic-rarely having a patient present (although, in some instances, an actor will portray the patient). Other members of the team, such as nurses, nurse practitioners, and biomedical engineers, are not traditionally involved in the formal teaching process. In this study we examine the rapid ideation in a clinical setting to forge a system of cross talk between engineers and physicians as a steady state at the praxis of ideation and implementation.

  9. The Origin of Families and $SO(18)$ Grand Unification

    CERN Document Server

    BenTov, Yoni

    2015-01-01

    We exploit a recent advance in the study of topological superconductors to propose a solution to the nagging family puzzle of particle physics in the context of SO(18) (or more correctly, Spin(18)) grand unification. We argue that Yukawa couplings of intermediate strength may allow the mirror matter and extra families to decouple at arbitrarily high energies. As was clear from the existing literature, we have to go beyond the Higgs mechanism in order to solve the family puzzle. A pattern of symmetry breaking which results in the SU(5) grand unified theory with horizontal or family symmetry USp(4) = Spin(5) (or more loosely, SO(5)) leaves exactly three light families of matter and seems particularly appealing. We comment briefly on an alternative scheme involving discrete non-abelian family symmetries. In a few lengthy appendices we review some of the pertinent condensed matter theory.

  10. Los grandes telescopios ópticos e infrarrojos

    Science.gov (United States)

    Rodríguez-Espinosa, J. M.

    Recientemente se han puesto en funcionamiento telescopios de 8 y 10 metros de diámetro de su espejo primario que están significando un gran avance en las capacidades observacionales de la Astronomía moderna. Igualmente en nuestro país se está construyendo el Gran Telescopio de Canarias (GTC) que situará a la Astronomía española en la vanguardia de esta disciplina. En mi charla hablaré de las oportunidades observacionales que suponen estos grandes telescopios para la Astronomía moderna. Hablaré del GTC y del esfuerzo español por ser actores principales del desarrollo de la Astronomía moderna. Por último, mostraré brevemente los proyectos futuros de grandes telescopios que se están proponiendo a ambos lados del Atlántico.

  11. Standardized methods for Grand Canyon fisheries research 2015

    Science.gov (United States)

    Persons, William R.; Ward, David L.; Avery, Luke A.

    2013-01-01

    This document presents protocols and guidelines to persons sampling fishes in the Grand Canyon, to help ensure consistency in fish handling, fish tagging, and data collection among different projects and organizations. Most such research and monitoring projects are conducted under the general umbrella of the Glen Canyon Dam Adaptive Management Program and include studies by the U.S. Geological Survey (USGS), U.S. Fish and Wildlife Service (FWS), National Park Service (NPS), the Arizona Game and Fish Department (AGFD), various universities, and private contractors. This document is intended to provide guidance to fieldworkers regarding protocols that may vary from year to year depending on specific projects and objectives. We also provide herein documentation of standard methods used in the Grand Canyon that can be cited in scientific publications, as well as a summary of changes in protocols since the document was first created in 2002.

  12. Cholera Outbreak in Grande Comore: 1998–1999

    Science.gov (United States)

    Troeger, Christopher; Gaudart, Jean; Truillet, Romain; Sallah, Kankoe; Chao, Dennis L.; Piarroux, Renaud

    2016-01-01

    In 1998, a cholera epidemic in east Africa reached the Comoros Islands, an archipelago in the Mozambique Channel that had not reported a cholera case for more than 20 years. In just a little over 1 year (between January 1998 and March 1999), Grande Comore, the largest island in the Union of the Comoros, reported 7,851 cases of cholera, about 3% of the population. Using case reports and field observations during the medical response, we describe the epidemiology of the 1998–1999 cholera epidemic in Grande Comore. Outbreaks of infectious diseases on islands provide a unique opportunity to study transmission dynamics in a nearly closed population, and they may serve as stepping-stones for human pathogens to cross unpopulated expanses of ocean. PMID:26572869

  13. Environmental Assessment Housing Transfer at Grand Forks AFB, North Dakota

    Science.gov (United States)

    2005-01-27

    of grasses, legumes, and wild herbaceous plants. Included in the grasses and legumes vegetation species are tall wheat grass, brome grass, Kentucky ...little bluestem, Indian grass, switchgrass, blue gramma, buffalo grass, and many native wildflower species. 35 Two hundred and fifty five taxa...were identified in the ND Natural Heritage Inventory and the BS Bioserve biological inventory update for Grand Forks Air Force Base. Two rare orchid

  14. Environmental Assessment Tent City at Grand Forks AFB, North Dakota

    Science.gov (United States)

    2004-11-15

    legumes, and wild herbaceous plants. Included in the grasses and legumes vegetation species are tall wheat grass, brome grass, Kentucky bluegrass, sweet...bluestem, Indian grass, switchgrass, blue gramma, buffalo grass, and many native wildflower species. Two hundred and fifty five taxa were...identified in the ND Natural Heritage Inventory and the BS Bioserve biological inventory update for Grand Forks Air Force Base. Two rare orchid species are

  15. China Overseas Plaza Mock-up Floor Grand Openning

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Global Leasing launched on Full Scale Beijing, November 6, 2008- China Overseas Plaza, located at the heart of the Beijing CBD with Chang'an Avenue to the south and China World Trade Center PhasenⅢto the east, is constructed including two international Grade-A office towers with a commercial podium. The developer held a grand opening ceremony on the completed mock-up floor the sixth floor of the South Tower.

  16. On Black Hole Entropy Corrections in the Grand Canonical Ensemble

    CERN Document Server

    Mahapatra, Subhash; Sarkar, Tapobrata

    2011-01-01

    We study entropy corrections due to thermal fluctuations for asymptotically AdS black holes in the grand canonical ensemble. To leading order, these can be expressed in terms of the black hole response coefficients via fluctuation moments. We also analyze entropy corrections due to mass and charge fluctuations of R-charged black holes, and our results indicate an universality in the logarithmic corrections to charged AdS black hole entropy in various dimensions.

  17. Grande Ronde Basin Supplementation Program; Lostine River, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Onjukka, Sam T. (Oregon Department of Fish and Wildlife, Portland, OR); Harbeck, Jim (Nez Perce Tribe, Department of Fisheries Resource Management, Enterprise, OR)

    2003-03-01

    The Northwest Power Planning Council (NPPC) identified supplementation as a high priority to achieve its goal of increasing runs of anadromous fish in the Columbia Basin. Supplementation activities in the Lostine River and associated monitoring and evaluation conducted by the Nez Perce Tribe relate directly to the needs addressed in the Columbia River Basin Fish and Wildlife Program (NPPC 1994). Measure 7.4L.1 of the Program mandates that appropriate research accompany any proposed supplementation. In addition, measure 7.3B.2 of the Program stresses the need for evaluating supplementation projects to assess their ability to increase production. Finally, Section 7.4D.3 encourages the study of hatchery rearing and release strategies to improve survival and adaptation of cultured fish. In 1997, Oregon Department of Fisheries and Wildlife (ODFW) requested a modification of Permit 1011 to allow the take of adult spring chinook salmon. In 1998, the Nez Perce Tribe also requested a permit specific to activities on Lostine River. The permit was issued in 2000. A special condition in the permits required the development of a long term management plan for the spring chinook salmon of the Grande Ronde Basin. The Nez Perce Tribe, ODFW, and the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) completed a formal long range plan entitled ''Grande Ronde Basin Endemic Spring Chinook Salmon Supplementation Program''. The program proposes to increase the survival of spring chinook salmon in the Grand Ronde Basin through hatchery intervention. Adult salmon from the Lostine River, Catherine Creek, and the Upper Grande Ronde River are used for a conventional supplementation program in the basin. The Nez Perce program currently operates under the ESA Section 10 Permit 1149.

  18. Environmental Assessment: Demolish 934 of Grand Forks Air Force Base

    Science.gov (United States)

    2006-03-01

    the “ Prairie View Nature Preserve” has been developed to restore a part of the native tallgrass prairie that once was dominant in this region...buffalo grass, and many native wildflower species. The Grand Forks AFB Natural Resources Manager installed a butterfly garden in the Prairie View...identified as jurisdictional. Vegetation is robust at GFAFB wetlands, and they are characterized as typical prairie potholes found within the

  19. Environmental Assessment - Demolish 934 of Grand Forks Air Force Base

    Science.gov (United States)

    2006-03-01

    in the “ Prairie View Nature Preserve” has been developed to restore a part of the native tallgrass prairie that once was dominant in this region...buffalo grass, and many native wildflower species. The Grand Forks AFB Natural Resources Manager installed a butterfly garden in the Prairie View...identified as jurisdictional. Vegetation is robust at GFAFB wetlands, and they are characterized as typical prairie potholes found within the

  20. Differential compaction mechanism for earth fissures near Casa Grande, Arizona.

    Science.gov (United States)

    Jachens, R.C.; Holzer, T.L.

    1982-01-01

    Precise gravity measurements indicate that earth fissures or tension cracks caused by ground-water withdrawal within a 10km2 area SE of Casa Grande are associated with relief on the buried interface between the alluvial aquifer and underlying bedrock. These relations suggest that the fissures are forming in response to localized differential compaction caused by localized variations of aquifer-system thickness. -from Authors

  1. L'espace mondial des grandes manifestations sportives internationales

    Directory of Open Access Journals (Sweden)

    Daniel MATHIEU

    1989-06-01

    Full Text Available La carte des grandes manifestations sportives mondiales montre une forte concentration des épreuves dans un petit nombre de pays développés, en particulier l'Europe occidentale. L'examen des nations concernées par les tournois majeurs du tennis et par le cyclisme professionnel soulignent, avec les nuances propres à chacun des sports, l'étroitesse des espaces intéressés.

  2. New records of Muscidae (Diptera) in Campo Grande, MS, Brazil.

    OpenAIRE

    2013-01-01

    Synanthropic flies outstanding beside other flies due their relative abundance close to domestic animals and human population, to which they are able to cause myiasis or transmit pathogenic agents. As they're necrophagous they act as corpse decomposers and are useful in the forensic entomology in the post mortem interval determination. This study aimed to know flies diversity and abundance in Campo Grande, State of Mato Grosso do Sul. Captures were made weekly, utilizing three traps baited wi...

  3. Basement structures over Rio Grande Rise from gravity inversion

    Science.gov (United States)

    Constantino, Renata Regina; Hackspacher, Peter Christian; de Souza, Iata Anderson; Lima Costa, Iago Sousa

    2017-04-01

    The basement depth in the Rio Grande Rise (RGR), South Atlantic, is estimated from combining gravity data obtained from satellite altimetry, marine surveys, bathymetry, sediment thickness and crustal thickness information. We formulate a crustal model of the region by inverse gravity modeling. The effect of the sediment layer is evaluated using the global sediment thickness model of National Oceanic and Atmospheric Administration (NOAA) and fitting the sediment compaction model to observed density values from Deep Sea Drilling Project (DSDP) reports. The Global Relief Model ETOPO1 and constraining data from seismic interpretation on crustal thickness are integrated in the inversion process. The modeled Moho depth values vary between 6 and 27 km over the area, being thicker under the RGR and also in the direction of São Paulo Plateau. The inversion for the gravity-equivalent basement topography is applied to gravity residual data, which is free from the gravity effect of sediments and from the gravity effect of the estimated Moho interface. We find several short-wavelengths structures not present in the bathymetry data. Our model shows a rift crossing the entire Rio Grande Rise deeper than previously presented in literature, with depths up to 5 km in the East Rio Grande Rise (ERGR) and deeper in the West Rio Grande Rise (WRGR), reaching 6.4 km. An interesting NS structure that goes from 34°S and extends through de São Paulo Ridge may be related to the South Atlantic Opening and could reveal an extinct spreading center.

  4. Grande Ronde Basin Supplementation Program; Lostine River, 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Onjukka, Sam T. (Oregon Department of Fish and Wildlife, Portland, OR); Harbeck, Jim (Nez Perce Tribe, Department of Fisheries Resource Management, Enterprise, OR)

    2003-03-01

    The Northwest Power Planning Council (NPPC) identified supplementation as a high priority to achieve its goal of increasing runs of anadromous fish in the Columbia Basin. Supplementation activities in the Lostine River and associated monitoring and evaluation conducted by the Nez Perce Tribe relate directly to the needs addressed in the Columbia River Basin Fish and Wildlife Program (NPPC 1994). Measure 7.4L.1 of the Program mandates that appropriate research accompany any proposed supplementation. In addition, measure 7.3B.2 of the Program stresses the need for evaluating supplementation projects to assess their ability to increase production. Finally, Section 7.4D.3 encourages the study of hatchery rearing and release strategies to improve survival and adaptation of cultured fish. In 1997, Oregon Department of Fisheries and Wildlife (ODFW) requested a modification of Permit 1011 to allow the take of adult spring chinook salmon. In 1998, the Nez Perce Tribe also requested a permit specific to activities on Lostine River. The permit was issued in 2000. A special condition in the permits required the development of a long term management plan for the spring chinook salmon of the Grande Ronde Basin. The Nez Perce Tribe, ODFW, and the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) completed a formal long range plan entitled ''Grande Ronde Basin Endemic Spring Chinook Salmon Supplementation Program''. The program proposes to increase the survival of spring chinook salmon in the Grand Ronde Basin through hatchery intervention. Adult salmon from the Lostine River, Catherine Creek, and the Upper Grande Ronde River are used for a conventional supplementation program in the basin. The Nez Perce program currently operates under the ESA Section 10 Permit 1149.

  5. Border Security: Is it Achievable on the Rio Grande?

    Science.gov (United States)

    2011-04-30

    the outposts along the Rio Grande River.13 A raid by Francisco “ Pancho ” Villa into New Mexico precipitated the Mexican Expedition by General John...J. “Blackjack” Pershing into Mexico to capture Villa . The Pancho Villa expedition, referred to colloquially as the "Punitive Expedition," was a...military operation conducted by the United States Army against the paramilitary forces of insurgent Villa from 1916 to 1917. This effort was in

  6. Deciphering Solar Magnetic Activity: On Grand Minima in Solar Activity

    Directory of Open Access Journals (Sweden)

    Scott William Mcintosh

    2015-07-01

    Full Text Available The Sun provides the energy necessary to sustain our existence. While the Sun provides for us, it is also capable of taking away. The weather and climatic scales of solar evolution and the Sun-Earth connection are not well understood. There has been tremendous progress in the century since the discovery of solar magnetism - magnetism that ultimately drives the electromagnetic, particulate and eruptive forcing of our planetary system. There is contemporary evidence of a decrease in solar magnetism, perhaps even indicators of a significant downward trend, over recent decades. Are we entering a minimum in solar activity that is deeper and longer than a typical solar minimum, a grand minimum? How could we tell if we are? What is a grand minimum and how does the Sun recover? These are very pertinent questions for modern civilization. In this paper we present a hypothetical demonstration of entry and exit from grand minimum conditions based on a recent analysis of solar features over the past 20 years and their possible connection to the origins of the 11(-ish year solar activity cycle.

  7. Electrical resistance sensors record spring flow timing, Grand Canyon, Arizona

    Science.gov (United States)

    Adams, E.A.; Monroe, S.A.; Springer, A.E.; Blasch, K.W.; Bills, D.J.

    2006-01-01

    Springs along the south rim of the Grand Canyon, Arizona, are important ecological and cultural resources in Grand Canyon National Park and are discharge points for regional and local aquifers of the Coconino Plateau. This study evaluated the applicability of electrical resistance (ER) sensors for measuring diffuse, low-stage (flow in the steep, rocky spring-fed tributaries of the south rim. ER sensors were used to conduct a baseline survey of spring flow timing at eight sites in three spring-fed tributaries in Grand Canyon. Sensors were attached to a nearly vertical rock wall at a spring outlet and were installed in alluvial and bedrock channels. Spring flow timing data inferred by the ER sensors were consistent with observations during site visits, with flow events recorded with collocated streamflow gauging stations and with local precipitation gauges. ER sensors were able to distinguish the presence of flow along nearly vertical rock surfaces with flow depths between 0.3 and 1.0 cm. Laboratory experiments confirmed the ability of the sensors to monitor the timing of diffuse flow on impervious surfaces. A comparison of flow patterns along the stream reaches and at springs identified the timing and location of perennial and intermittent flow, and periods of increased evapotranspiration.

  8. Deciphering Solar Magnetic Activity: On Grand Minima in Solar Activity

    CERN Document Server

    McIntosh, Scott W

    2015-01-01

    The Sun provides the energy necessary to sustain our existence. While the Sun provides for us, it is also capable of taking away. The weather and climatic scales of solar evolution and the Sun-Earth connection are not well understood. There has been tremendous progress in the century since the discovery of solar magnetism - magnetism that ultimately drives the electromagnetic, particulate and eruptive forcing of our planetary system. There is contemporary evidence of a decrease in solar magnetism, perhaps even indicators of a significant downward trend, over recent decades. Are we entering a minimum in solar activity that is deeper and longer than a typical solar minimum, a "grand minimum"? How could we tell if we are? What is a grand minimum and how does the Sun recover? These are very pertinent questions for modern civilization. In this paper we present a hypothetical demonstration of entry and exit from grand minimum conditions based on a recent analysis of solar features over the past 20 years and their p...

  9. Thank You, Challenges!

    Institute of Scientific and Technical Information of China (English)

    陈晨; 陈传光

    2016-01-01

    A person may meet many challenges in his or her life.Some people think challenges are terrible.But I think they’re great.And I want to say,"Thank you,challenges!"For some people,it’s hard to face the challenges because they are afraid of failing in the end.However,it’s necessary for a person to face the challenges.Challenges are good to~①you.

  10. Environmental assessment of facility operations at the U.S. Department of Energy Grand Junction Projects Office, Grand Junction, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    The US Department of Energy (DOE) has prepared a sitewide environmental assessment (EA) of the proposed action to continue and expand present-day activities on the DOE Grand Junction Projects Office (GJPO) facility in Grand Junction, Colorado. Because DOE-GJPO regularly proposes and conducts many different on-site activities, DOE decided to evaluate these activities in one sitewide EA rather than in multiple, activity-specific documents. On the basis of the information and analyses presented in the EA, DOE has determined that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment, as defined by the National Environmental Policy Act (NEPA) of 1969. Therefore, preparation of an environmental impact statement is not required for facility operations, and DOE is issuing this Finding of No Significant Impact (FONSI).

  11. Microbial contamination and chemical toxicity of the Rio Grande

    Directory of Open Access Journals (Sweden)

    Valles Adrian

    2004-04-01

    Full Text Available Abstract Background The Rio Grande River is the natural boundary between U.S. and Mexico from El Paso, TX to Brownsville, TX. and is one of the major water resources of the area. Agriculture, farming, maquiladora industry, domestic activities, as well as differences in disposal regulations and enforcement increase the contamination potential of water supplies along the border region. Therefore, continuous and accurate assessment of the quality of water supplies is of paramount importance. The objectives of this study were to monitor water quality of the Rio Grande and to determine if any correlations exist between fecal coliforms, E. coli, chemical toxicity as determined by Botsford's assay, H. pylori presence, and environmental parameters. Seven sites along a 112-Km segment of the Rio Grande from Sunland Park, NM to Fort Hancock, TX were sampled on a monthly basis between January 2000 and December 2002. Results The results showed great variability in the number of fecal coliforms, and E. coli on a month-to-month basis. Fecal coliforms ranged between 0–106 CFU/100 ml while E. coli ranged between 6 to > 2419 MPN. H. pylori showed positive detection for all the sites at different times. Toxicity ranged between 0 to 94% of inhibition capacity (IC. Since values above 50% are considered to be toxic, most of the sites displayed significant chemical toxicity at different times of the year. No significant correlations were observed between microbial indicators and chemical toxicity. Conclusion The results of the present study indicate that the 112-Km segment of the Rio Grande river from Sunland Park, NM to Fort Hancock, TX exceeds the standards for contact recreation water on a continuous basis. In addition, the presence of chemical toxicity in most sites along the 112-Km segment indicates that water quality is an area of concern for the bi-national region. The presence of H. pylori adds to the potential health hazards of the Rio Grande. Since no

  12. Pathogenic landscape of transboundary zoonotic diseases in the Mexico-US border along the Rio Grande

    Directory of Open Access Journals (Sweden)

    Maria Dolores Esteve-Gasent

    2014-11-01

    Full Text Available Transboundary zoonotic diseases, several of which are vector borne, can maintain a dynamic focus, and have pathogens circulating in geographic regions encircling multiple geopolitical boundaries. Global change is intensifying transboundary problems including the spatial variation of the risk and incidence of zoonotic diseases. The complexity of these challenges can be greater in areas where rivers delineate international boundaries and encompass transitions between ecozones. The Rio Grande serves as a natural border between the US State of Texas and the Mexican States of Chihuahua, Coahuila, Nuevo León, and Tamaulipas. Not only millions of people live in this transboundary region but also a substantial movement of goods and people pass through it everyday. Moreover, it occurs over a region that functions as a corridor for animal migrations, and thus links the Neotropic and Nearctic biogeographic zones, with the latter being a known foci of zoonotic diseases. However, the pathogenic landscape of important zoonotic diseases in the south Texas-Mexico transboundary region remains to be fully understood. An international perspective on the interplay between disease systems, ecosystem processes, land use, and human behaviors is applied here to analyze landscape and spatial features of Venezuelan equine encephalitis, Hantavirus disease, Lyme Borreliosis, Leptospirosis, Bartonellosis, Chagas disease, human Babesiosis, and Leishmaniasis. Surveillance systems following the One Health approach with a regional perspective will help identifying opportunities to mitigate the health burden of those diseases on human and animal populations. It is proposed that the Mexico-US border, along the Rio Grande region be viewed as a continuum landscape where zoonotic pathogens circulate regardless of national borders.

  13. Pathogenic Landscape of Transboundary Zoonotic Diseases in the Mexico-US Border Along the Rio Grande.

    Science.gov (United States)

    Esteve-Gassent, Maria Dolores; Pérez de León, Adalberto A; Romero-Salas, Dora; Feria-Arroyo, Teresa P; Patino, Ramiro; Castro-Arellano, Ivan; Gordillo-Pérez, Guadalupe; Auclair, Allan; Goolsby, John; Rodriguez-Vivas, Roger Ivan; Estrada-Franco, Jose Guillermo

    2014-01-01

    Transboundary zoonotic diseases, several of which are vector borne, can maintain a dynamic focus and have pathogens circulating in geographic regions encircling multiple geopolitical boundaries. Global change is intensifying transboundary problems, including the spatial variation of the risk and incidence of zoonotic diseases. The complexity of these challenges can be greater in areas where rivers delineate international boundaries and encompass transitions between ecozones. The Rio Grande serves as a natural border between the US State of Texas and the Mexican States of Chihuahua, Coahuila, Nuevo León, and Tamaulipas. Not only do millions of people live in this transboundary region, but also a substantial amount of goods and people pass through it everyday. Moreover, it occurs over a region that functions as a corridor for animal migrations, and thus links the Neotropic and Nearctic biogeographic zones, with the latter being a known foci of zoonotic diseases. However, the pathogenic landscape of important zoonotic diseases in the south Texas-Mexico transboundary region remains to be fully understood. An international perspective on the interplay between disease systems, ecosystem processes, land use, and human behaviors is applied here to analyze landscape and spatial features of Venezuelan equine encephalitis, Hantavirus disease, Lyme Borreliosis, Leptospirosis, Bartonellosis, Chagas disease, human Babesiosis, and Leishmaniasis. Surveillance systems following the One Health approach with a regional perspective will help identifying opportunities to mitigate the health burden of those diseases on human and animal populations. It is proposed that the Mexico-US border along the Rio Grande region be viewed as a continuum landscape where zoonotic pathogens circulate regardless of national borders.

  14. Pathogenic Landscape of Transboundary Zoonotic Diseases in the Mexico–US Border Along the Rio Grande

    Science.gov (United States)

    Esteve-Gassent, Maria Dolores; Pérez de León, Adalberto A.; Romero-Salas, Dora; Feria-Arroyo, Teresa P.; Patino, Ramiro; Castro-Arellano, Ivan; Gordillo-Pérez, Guadalupe; Auclair, Allan; Goolsby, John; Rodriguez-Vivas, Roger Ivan; Estrada-Franco, Jose Guillermo

    2014-01-01

    Transboundary zoonotic diseases, several of which are vector borne, can maintain a dynamic focus and have pathogens circulating in geographic regions encircling multiple geopolitical boundaries. Global change is intensifying transboundary problems, including the spatial variation of the risk and incidence of zoonotic diseases. The complexity of these challenges can be greater in areas where rivers delineate international boundaries and encompass transitions between ecozones. The Rio Grande serves as a natural border between the US State of Texas and the Mexican States of Chihuahua, Coahuila, Nuevo León, and Tamaulipas. Not only do millions of people live in this transboundary region, but also a substantial amount of goods and people pass through it everyday. Moreover, it occurs over a region that functions as a corridor for animal migrations, and thus links the Neotropic and Nearctic biogeographic zones, with the latter being a known foci of zoonotic diseases. However, the pathogenic landscape of important zoonotic diseases in the south Texas–Mexico transboundary region remains to be fully understood. An international perspective on the interplay between disease systems, ecosystem processes, land use, and human behaviors is applied here to analyze landscape and spatial features of Venezuelan equine encephalitis, Hantavirus disease, Lyme Borreliosis, Leptospirosis, Bartonellosis, Chagas disease, human Babesiosis, and Leishmaniasis. Surveillance systems following the One Health approach with a regional perspective will help identifying opportunities to mitigate the health burden of those diseases on human and animal populations. It is proposed that the Mexico–US border along the Rio Grande region be viewed as a continuum landscape where zoonotic pathogens circulate regardless of national borders. PMID:25453027

  15. Bioética, violência e desigualdade: as biociências e a constituição do biopoder Bioethics, violence and inequality: the biosciences and the conquest of biopower

    Directory of Open Access Journals (Sweden)

    Hélder Boska de Moraes Sarmento

    2008-12-01

    Full Text Available A sociedade contemporânea está atravessada por contradições e paradoxos, dentre os quais vale destacar a relação entre a alta tecnologia e, a pior situação humana, a miséria. Resultado das escolhas éticas e políticas desta era tecnológica, vive-se em situações de fronteira, nas quais as biociências desempenham papel central, tanto no volume de conhecimentos gerados, como na utilização de seus resultados, que, sem controle social, ampliam desigualdades. O objetivo deste artigo é demonstrar o quanto as biociências articulam-se com o desenvolvimento científico dos países inovadores de tecnologia, criando uma nova relação de poder, violento e desigual para os que apenas a consomem, denominado de biopoder. Daí a necessidade de uma bioética crítica capaz de empreender reflexões sobre os procedimentos técnicos, os fundamentos da atividade científica, sua aplicabilidade e relação com o mercado, oportunizando uma 'ponte' na tomada de decisões para que a própria ciência não se torne um obstáculo à democracia.Contemporary society is rife with contradictions and paradoxes, among which stand out the relationship between high technology and the worst human situation, poverty. The result of ethical and political choices of this technological era, we experience frontier situations, in which the biosciences play a central role, both in the volume of knowledge generated, as well as in the use of their results which, without social control, broaden inequalities. The objective of this article is to demonstrate the degree to which the biosciences are articulated with the scientific development of the countries that innovate technologies, creating a new relationship of power, which is violent and unequal for those who only consume, denominated biopower. This creates a need for a critical bioethics that is capable of reflecting on the technical procedures, the bases of scientific activity and their applicability and relation with

  16. Grandes sistemas fluviais tropicais: uma visão geral

    Directory of Open Access Journals (Sweden)

    Rajiv Sinha

    2005-11-01

    Full Text Available Muitos dos grandes rios e dos leques aluviais existentes estão situados em áreas tropicais e constituem os maiores sistemas de estoque e transferência de sedimentos e nutrientes para o oceano. O presente trabalho visa a apresentação e análise geral dos grandes sistemas fluviais e leques aluviais (área da bacia entre 104 e 6 x 106 km de regiões tropicais com precipitação acima de 700 mm anuais. Os grandes sistemas fluviais tropicais foram aqui classificados de acordo com o arcabouço geológico-geomorfológio de suas bacias em: a Cinturões orogenênicos de montanha, b Platô/plataforma basáltico-sedimentar, c Áreas cratônicas, d Planícies em áreas de bacias sedimentares, e e Áreas mistas. De modo geral, os rios analisados apresentam um pico de descarga bastante definido e variável durante a estação chuvosa e um período de baixa vazão na estação seca. Os dados dos rios sul-americanos e asiáticos de áreas continentais e orogênicas agruparam-se quando lançados num diagrama do suprimento de sedimentos versus descarga média anual, e apresentaram valores mais elevados que aqueles asiáticos insulares. Já rios de áreas de plataforma ou cratônicas, tanto em área de savana como nos trópicos úmidos, caracterizaram-se por terem baixo transporte de sedimento. Especialmente nas grandes bacias, os rios apresentam toda a gama de formas de canal, inviabilizando a classificação tradicional de canal meandrante, reto e entrelaçado, sendo nesse caso mais sugestiva a aplicação da terminologia de sistema uni ou multi-canal ou de complexo anastomosado.É também discutido, brevemente, o atual estado do conhecimento dos sistemas fluviais tropicais e seu potencial na aplicação na interpretação de antigas seqüências e na modelagem de fácies sedimentar. Os principais impactos ambientais a que os grandes sistemas fluviais tropicais estão submetidos incluem as mudanças no uso agrosilpastoril das terras, mineração, barragens

  17. El poder de las grandes empresas petroleras: 1900–1950

    Directory of Open Access Journals (Sweden)

    Jesús Mora Contreras

    2003-01-01

    Full Text Available Entre 1900 y 1950 las grandes corporaciones petroleras internacionales lograron imponer a los propietarios del recurso natural en el Medio Oriente y en Venezuela las normas y procedimientos que regulaban contractual y legalmente las actividades de exploración y explotación de petróleo. Lograron además crear un cartel interna-cional de empresas productoras para dividirse el mercado entre ellas e imponer a los consumidores un sistema de fijación del precio mundial del “crudo”.

  18. Grand unification in extra dimensions and proton decay

    Energy Technology Data Exchange (ETDEWEB)

    Feruglio, F. [Universita di Padova and INFN, Dipt. di Fisica, Padova (Italy)

    2001-07-01

    We discuss baryon and lepton violation in the context of a simple-dimensional grand unified model, based on the orbifold S{sup 1}/(Z{sub 2} x Z'{sub 2}). While gauge and Higgs degrees of freedom live in the bulk, matter is located on the boundaries of the space-time. We show that proton decay is naturally suppressed or even forbidden by suitable implementations of the parity symmetries in the mater sector. The corresponding mechanism does not affect the SU(5) description of fermion masses also including neutrinos. (author)

  19. Ethical Grand Rounds: Teaching Ethics at the Point of Care.

    Science.gov (United States)

    Airth-Kindree, Norah M M; Kirkhorn, Lee-Ellen C

    2016-01-01

    We offer an educational innovation called Ethical Grand Rounds (EGR) as a teaching strategy to enhance ethical decision-making. Nursing students participate in EGR-flexible ethical laboratories, where they take stands on ethical dilemmas, arguing for--or against--an ethical principle. This process provides the opportunity to move past normative ethics, that is, an ideal ethical stance in accord with ethical conduct codes, to applied ethics, what professional nurses would do in actual clinical practice, given the constraints that exist in contemporary care settings. EGR serves as a vehicle to translate "what ought to be" into "what is."

  20. Grande Ronde Basin Fish Habitat Enhancement Project : 2000 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Vance R.; Powell, Russ M.; Stennfeld, Scott P.

    2001-04-01

    On July 1, 1984 the Bonneville Power Administration and the Oregon Department of Fish and Wildlife entered into an agreement to initiate fish habitat enhancement work in the Joseph Creek subbasin of the Grande Ronde River Basin in northeast Oregon. In July of 1985 the Upper and Middle Grande Ronde River, and Catherine Creek subbasins were included in the intergovernmental contract, and on March 1, 1996 the Wallowa River subbasin was added. The primary goal of ''The Grande Ronde Basin Fish Habitat Enhancement Project'' is to access, create, improve, protect, and restore riparian and instream habitat for anadromous salmonids, thereby maximizing opportunities for natural fish production within the basin. This project provided for implementation of Program Measure 703 (C)(1), Action Item 4.2 of the Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program (NPPC, 1987), and continues to be implemented as offsite mitigation for mainstem fishery losses caused by the Columbia River hydro-electric system. All work conducted by the Oregon Department of Fish and Wildlife is on private lands and therefore requires that considerable time be spent developing rapport with landowners to gain acceptance of, and continued cooperation with this program throughout 10-15 year lease periods. This project calls for passive regeneration of habitat, using riparian enclosure fencing as the primary method to restore degraded streams to a normative condition. Active remediation techniques using plantings, off-site water developments, site-specific instream structures, or whole channel alterations are also utilized where applicable. Individual projects contribute to and complement ecosystem and basin-wide watershed restoration efforts that are underway by state, federal, and tribal agencies, and local watershed councils. Work undertaken during 2000 included: (1) Implementing 2 new projects in the Grande Ronde drainage, and retrofitting one old

  1. Baryon number violation catalysed by grand unified monopoles

    CERN Document Server

    Ellis, Jonathan Richard; Olive, Keith A

    1982-01-01

    It has been recognized for some time that grand unified monopoles may catalyze Delta B not=0 processes. The authors obtain model-independent upper bounds on the rates for such reactions from the survival of the baryon number generated in the early Universe and from present-day baryon stability. These constraints are compatible with recent estimates of large baryon number violating monopole cross sections, but a monopole flux close to present experimental upper limits could be detectable in forthcoming baryon decay experiments. The authors mention signatures for monopole-induced baryon 'decay' and point out that it could be used to solve the energy crisis.

  2. SU(5) grand unification in a transfinite form

    Energy Technology Data Exchange (ETDEWEB)

    El Naschie, M.S. [King Abdul Aziz City of Science and Technology, Riyadh (Saudi Arabia)

    2007-04-15

    The SU(5) grand unification with its vertical bar SU(5) vertical bar = 24 gauge Bosons is partially reformulated in a transfinite setting. By means of transfinite continuation it is shown that a new version of the theory yields an expectation value < vertical bar SU(5) vertical bar {sub c}> = 26 + k instead of the classical 24. By systematically exploring the non-super symmetric SU(5) scheme and transforming many of its fundamental aspects, it becomes plausible that it is a fundamental theory which could be integrated in various other fundamental theories including the transfinite forms of super strings and M theory.

  3. Simone de Beauvoir - a grande dama do feminismo

    Directory of Open Access Journals (Sweden)

    Rosa Alice Caubet

    2008-04-01

    Full Text Available A primeira mulher em que se pensa quando se procura, na literatura francesa, o exemplo de uma mulher que seja também uma grande escritora, é seguramente Colette. Mas, se em sua vida Colette foi uma feminista convicta, se teve um comportamento que desafiava toda e qualquer convenção da sociedade machista - mesmo que consideremos os padrões atuais - as suas personagens de meia idade e seu extenso bestiário têm, pela maneira como ela aborda esses temas, relentos de misoginia.

  4. Rio Grande Rift GPS Measurements 2006-2009

    Science.gov (United States)

    Berglund, H.; Sheehan, A. F.; Nerem, R.; Choe, J.; Lowry, A. R.; Roy, M.; Blume, F.; Murray, M.

    2009-12-01

    We use three years of measurements from 25 continuous GPS stations across the Rio Grande Rift in New Mexico and Colorado to estimate surface velocities, time series, baselines, and strain rates. The stations are part of the EarthScope Rio Grande Rift experiment, a collaboration between researchers at the University of Colorado at Boulder, the University of New Mexico, and Utah State University. The network includes 5 east-west station profiles transecting the rift, with the southernmost line in southern New Mexico and the northernmost line in northern Colorado. Most of the stations have shallow-drilled braced monuments installed in 2006-2007 and will remain occupied until 2010-2011 or longer. We also estimate station coordinates and velocities from the 2001 and 2008 High Accuracy Reference Network (HARN) campaigns conducted in Colorado. Initial 72-hour observations were made in the summer of 2001 and were repeated in the summer of 2008. Data from regional Plate Boundary Observatory (PBO) GPS stations are included in the processing to increase station density and extend profiles further to the east and west of the Rio Grande Rift. We use GAMIT/GLOBK to process regional sub-networks that share several common sites well determined in the Stable North America Reference Frame (SNARF). These common sites are used as a tie between the sub-networks and SNARF. Our time series from the first three years of the experiment show excellent monument stability. We have solved for baseline distance as a function of time across each of these lines. Despite what might be expected for a rigid Colorado Plateau moving away from rigid North America about a pole near Colorado, we find no evidence of an increase in Rio Grande Rift opening to the south. Our results suggest that steady-state extension across the rift from northern Colorado to southern New Mexico has an upper bound less than ~1 mm/yr with strain rates less than ~20 nanostrain/yr, although these results are still preliminary

  5. Nursing in a complex world: a case for grand theory.

    Science.gov (United States)

    Florczak, Kristine; Poradzisz, Michele; Hampson, Susan

    2012-10-01

    The authors of this column put forth a call for more grand theory to be used as the basis of nursing research. To that end, complexity theory and the Neuman systems model are reviewed followed by a discussion of the links that occur between them. Then evidence of the increased use of middle-range theory as the foundation of current nursing research is put forth. Finally, there is a discussion about the authors' conclusion that the complexity of the phenomena of interest for nursing research requires theories to be used as underpinnings that are more abstract and less reductionistic.

  6. Grande Ronde Endemic Spring Chinook Project - ODFW, 2008 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, Scott

    2009-04-10

    Core activities of the Grande Ronde Endemic Spring Chinook Supplementation Program (GRESCSP) are funded through the authority of the Lower Snake River Fish and Wildlife Compensation Plan (LSRCP). The LSRCP program was approved by the Water Resources Development Act of 1976, PL 94-587, Section 102, 94th Congress substantially in accordance with the Special Report, LSRCP, June 1975 on file with the Chief of Engineers. The LSRCP was prepared and submitted in compliance with the Fish and Wildlife Coordination Act of 1958, PL 85-624, 85th Congress, August 12, 1958 to mitigate for the losses of fish and wildlife caused by the construction of dams on lower Snake River. The GRESCSP is an artificial propagation program that was initiated by Bonneville Power Administrations Fish and Wildlife program in the mid 1990's. The intent of this program was to change the mitigation aspect of the LSRCP program (harvest mitigation) to an integrated supplementation program; inasmuch as, hatchery produced fish could be experimentally used as a recovery tool and fish surplus to mitigation would be available for in-place and in-kind harvest. Fish production is still authorized by the LSRCP with the original mitigation return goal of 5,860 adult spring Chinook to the project area. The GRESCSP was developed with two primary components: (1) conventional broodstock (projects 199800702; 199800703; 199800704) and (2) captive brood (projects 199801001; 199801006). The GRESCSP relies on cooperative M&E efforts from the LSRCP including setting aside the Wenaha and Minam tributaries as natural production reserves components used for reference streams. The GRESCSP, coordinated with federal and tribal partners, identifies production levels for both propagation components and weir management strategies for each of the three supplemented tributary areas within the Grande Ronde Sub-basin. The three supplemented areas are Catherine Creek, Lostine River, and upper Grande Ronde River. Lookingglass

  7. Radiation effects on science instruments in Grand Tour type missions

    Science.gov (United States)

    Parker, R. H.

    1972-01-01

    The extent of the radiation effects problem is delineated, along with the status of protective designs for 15 representative science instruments. Designs for protecting science instruments from radiation damage is discussed for the various instruments to be employed in the Grand Tour type missions. A literature search effort was undertaken to collect science instrument components damage/interference effects data on the various sensitive components such as Si detectors, vidicon tubes, etc. A small experimental effort is underway to provide verification of the radiation effects predictions.

  8. Google Science Fair 2012 : Grand Prize Winner Brittany Wenger

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    17-18 age category AND Grand Prize Winner: Brittany Wenger (USA)—“Global Neural Network Cloud Service for Breast Cancer.” Brittany’s project harnesses the power of the cloud to help doctors accurately diagnose breast cancer. Brittany built an application that compares individual test results to an extensive dataset stored in the cloud, allowing doctors to assess tumors using a minimally-invasive procedure. Brittany Michelle Wenger, and her mother, passed through the CERN Control Centre accompanied by Mike Lamont, CERN Beams Department, Operation Group Leader.

  9. LabTrove: a lightweight, web based, laboratory "blog" as a route towards a marked up record of work in a bioscience research laboratory.

    Directory of Open Access Journals (Sweden)

    Andrew J Milsted

    Full Text Available BACKGROUND: The electronic laboratory notebook (ELN has the potential to replace the paper notebook with a marked-up digital record that can be searched and shared. However, it is a challenge to achieve these benefits without losing the usability and flexibility of traditional paper notebooks. We investigate a blog-based platform that addresses the issues associated with the development of a flexible system for recording scientific research. METHODOLOGY/PRINCIPAL FINDINGS: We chose a blog-based approach with the journal characteristics of traditional notebooks in mind, recognizing the potential for linking together procedures, materials, samples, observations, data, and analysis reports. We implemented the LabTrove blog system as a server process written in PHP, using a MySQL database to persist posts and other research objects. We incorporated a metadata framework that is both extensible and flexible while promoting consistency and structure where appropriate. Our experience thus far is that LabTrove is capable of providing a successful electronic laboratory recording system. CONCLUSIONS/SIGNIFICANCE: LabTrove implements a one-item one-post system, which enables us to uniquely identify each element of the research record, such as data, samples, and protocols. This unique association between a post and a research element affords advantages for monitoring the use of materials and samples and for inspecting research processes. The combination of the one-item one-post system, consistent metadata, and full-text search provides us with a much more effective record than a paper notebook. The LabTrove approach provides a route towards reconciling the tensions and challenges that lie ahead in working towards the long-term goals for ELNs. LabTrove, an electronic laboratory notebook (ELN system from the Smart Research Framework, based on a blog-type framework with full access control, facilitates the scientific experimental recording requirements for

  10. Sleep bruxism: challenges and restorative solutions

    Directory of Open Access Journals (Sweden)

    Mengatto CM

    2016-04-01

    Full Text Available Cristiane Machado Mengatto, Fábio Herrmann Coelho-de-Souza, Oswaldo Baptista de Souza Junior Department of Conservative Dentistry, School of Dentistry, Federal University of Rio Grande do Sul (UFRGS, Porto Alegre, Brazil Abstract: Bruxism is a parafunctional activity related to clenching or grinding the teeth and tooth wear can be a consequence of sleep bruxism (SB. Management of severe tooth wear due to SB is a challenging situation because of the common reduced amount of remaining dental structure and loss of vertical dimension of occlusion. Rationale for the planning of oral rehabilitation of patients with SB presenting severe tooth wear should rely on evidence-based approaches; however, few studies have discussed properties of dental materials for SB rehabilitation and how to cosmetically manage severe tooth wear. This review aimed to provide an overview into bruxism cosmetic rehabilitation and how this can be implemented with good outcomes for the patient. Keywords: sleep bruxism, restoration, rehabilitation, prosthodontics, dentistry

  11. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    Science.gov (United States)

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  12. Environmental Assessment: Construct Airfield Lighting Vault and Demolish Building 531 at Grand Forks Air Force Base

    Science.gov (United States)

    2007-08-01

    in the grasses and legumes vegetation species are tall wheat grass, brome grass, Kentucky bluegrass, sweet clover, and alfalfa. Herbaceous plants...gramma, buffalo grass, and many native wildflower species. The Grand Forks AFB Natural Resources Manager and volunteers installed a butterfly garden in...Bioserve biological inventory update for Grand Forks Air Force Base. Two rare orchid species are known to exist on Grand Forks AFB, the Large and

  13. Environmental Assessment: Construct a CDC Main Entry Addition at Grand Forks Air Force Base

    Science.gov (United States)

    2006-03-01

    Included in the grasses and legumes vegetation species are tall wheat grass, brome grass, Kentucky bluegrass, sweet clover, and alfalfa. Herbaceous...gramma, buffalo grass, and many native wildflower species. The Grand Forks AFB Natural Resources Manager and volunteers installed a butterfly garden...Bioserve biological inventory update for Grand Forks Air Force Base. Two rare orchid species are known to exist on Grand Forks AFB, the Large and

  14. Assessing Grand Strategies: How the EU and NATO Rock the Strategic Boat

    Science.gov (United States)

    2015-05-01

    arose. Sir Basil Henry Liddell Hart dynamically contributed to the debate by promoting the concept of grand strategy.50 However, the concept of grand...the Science of War, 105–6. Corbett, Some Principles of Maritime Strategy, 308. 58. Basil Henry Liddell Hart, Strategy, 2nd rev. ed (New York, N.Y... Moore , advocate that the NATO Strategic Concept constitutes a NATO grand strategy more ostensibly.7 These disparate analyses merely reflect the

  15. 110 Years of Humiliation From 1839 to 1949: China’s Grand Strategy

    Science.gov (United States)

    2016-06-10

    2003). From this study, there is an indication that China’s grand strategy seeks to increase economic growth, military readiness, and global power...grand strategy seeks to increase economic growth and global power to undo the century of humiliation. This study adds to the body of literature in...110 YEARS OF HUMILIATION FROM 1839 TO 1949: CHINA’S GRAND STRATEGY A thesis presented to the Faculty of the U.S. Army Command

  16. The La Grande hydroelectric development - James Bay, Quebec

    Energy Technology Data Exchange (ETDEWEB)

    Pare, J-J.; Levay, J.

    1997-10-01

    An historical overview of the James Bay Hydroelectric Power Development in northern Quebec was provided. The account touches upon the foundation of the Societe d`energie de la Baie James, a wholly-owned subsidiary of Hydro-Quebec. It describes the La Grande Complex, and provides a brief summary of the site investigation, the geological and geotechnical considerations, the rock excavation, the construction of embankments and dikes, and nature of the bedrock and overburden foundations. Some of the more interesting problems that arose during the construction such as the settling of the crest in the protective islands surrounding the instruments at some of the dam sites were outlined. Leakage under some of the La Grande 3 low head dikes near the end of the reservoir filling period and the degradation of some of the riprap protection of the Phase One embankments were also described. The solutions designed to overcome these problems were also part of the account of this major mega development project that promoted Quebec into the ranks of the major hydro energy producers in North America. 11 refs., 2 tabs., 3 figs., photos.

  17. Female homicide in Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Gabriela Tomedi Leites

    2014-09-01

    Full Text Available This study aimed to assess the female homicide rate due to aggression in Rio Grande do Sul, Brazil, using this as a "proxy" of femicide. This was an ecological study which correlated the female homicide rate due to aggression in Rio Grande do Sul, according to the 35 microregions defined by the Brazilian Institute of Geography and Statistics (IBGE, with socioeconomic and demographic variables access and health indicators. Pearson's correlation test was performed with the selected variables. After this, multiple linear regressions were performed with variables with p < 0.20. The standardized average of female homicide rate due to aggression in the period from 2003 to 2007 was 3.1 obits per 100 thousand. After multiple regression analysis, the final model included male mortality due to aggression (p = 0.016, the percentage of hospital admissions for alcohol (p = 0.005 and the proportion of ill-defined deaths (p = 0.015. The model have an explanatory power of 39% (adjusted r2 = 0.391. The results are consistent with other studies and indicate a strong relationship between structural violence in society and violence against women, in addition to a higher incidence of female deaths in places with high alcohol hospitalization.

  18. Grand Unification as a Bridge Between String Theory and Phenomenology

    Energy Technology Data Exchange (ETDEWEB)

    Pati, Jogesh C.

    2006-06-09

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2){sub L} x SU(2){sub R} x SU(4){sup c} or SO(10) symmetry in 4D in explaining (1) observed neutrino oscillations, (2) baryogenesis via leptogenesis, and (3) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in {mu} {yields} e{gamma}, {tau} {yields} {mu}{gamma}, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  19. Geomorphology of plutonium in the Northern Rio Grande

    Energy Technology Data Exchange (ETDEWEB)

    Graf, W.L. [Arizona Univ., Tempe, AZ (United States). Dept., of Geography

    1993-03-01

    Nearly all of the plutonium in the natural environment of the Northern Rio Grande is associated with soils and sediment, and river processes account for most of the mobility of these materials. A composite regional budget for plutonium based on multi-decadal averages for sediment and plutonium movement shows that 90 percent of the plutonium moving into the system is from atmospheric fallout. The remaining 10 percent is from releases at Los Alamos. Annual variation in plutonium flux and storage exceeds 100 percent. The contribution to the plutonium budget from Los Alamos is associated with relatively coarse sediment which often behaves as bedload in the Rio Grande. Infusion of these materials into the main stream were largest in 1951, 1952, 1957, and 1968. Because of the schedule of delivery of plutonium to Los Alamos for experimentation and weapons manufacturing, the latter two years are probably the most important. Although the Los Alamos contribution to the entire plutonium budget was relatively small, in these four critical years it constituted 71--86 percent of the plutonium in bedload immediately downstream from Otowi.

  20. Mandibular fracture cases in Pelotas, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Rafael Silva da Silva

    2009-10-01

    Full Text Available Objectives: To analyze the data in the literature, which show a high incidence of mandibular fractures. The aim of this research was to elucidate the context in which these fractures occur among patients attended at the first aid center of “Pronto Socorro Municipal de Pelotas”, Rio Grande do Sul, Brazil. Methods: From the records referring to the period of June, 2001 to August, 2007, there were 1 345 patients with facial fractures. Of this total, 116 patients with mandibular fracture were selected for this study and the items analysed were: age, gender, mandibular fracture site, etiology and period of the year. Results: It was found that 86.2% of the sample were men. The most prevalent age was 20 to 29 years old representing 36.2%, and the most affected mandibular sites were the body, with 29 cases (25%, and the condyle, with 26 cases (22.4%. The most common cause of fractures was the physical aggression representing 37.1%. The period of the year with the highest incidence of mandibular fractures was the summer, with 38 cases (32.8%. Conclusion: It was therefore observed that the patients with mandibular fracture assisted at Pronto-Socorro Municipal de Pelotas, Rio Grande do Sul, Brazil, were generally men, 20 to 29 years old with mandibular body fracture and they were victims of physical aggression.

  1. Grand Unification as a Bridge Between String Theory and Phenomenology

    Science.gov (United States)

    Pati, Jogesh C.

    In the first part of this paper, we explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity — be it string/M-theory or a reincarnation — this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2)L × SU(2)R × SU(4)c or SO(10) symmetry in 4D in explaining (i) observed neutrino oscillations, (ii) baryogenesis via leptogenesis, and (iii) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in μ → eγ, τ → μγ, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we have had in our understanding of nature so far, and the current difficulties of string/M-theory as regards the large multiplicity of string vacua, some comments are made on the traditional goal of understanding vis a vis the recently evolved view of landscape and anthropism.

  2. Grand Unification as a Bridge Between String Theory and Phenomenology

    CERN Document Server

    Pati, J C

    2006-01-01

    In the first part of the talk, I explain what empirical evidence points to the need for having an effective grand unification-like symmetry possessing the symmetry SU(4)-color in 4D. If one assumes the premises of a future predictive theory including gravity--be it string/M theory or a reincarnation--this evidence then suggests that such a theory should lead to an effective grand unification-like symmetry as above in 4D, near the string-GUT-scale, rather than the standard model symmetry. Advantages of an effective supersymmetric G(224) = SU(2)$_L \\times$ SU(2)$_R \\times$ SU(4)$^c$ or SO(10) symmetry in 4D in explaining (i) observed neutrino oscillations, (ii) baryogenesis via leptogenesis, and (iii) certain fermion mass-relations are noted. And certain distinguishing tests of a SUSY G(224) or SO(10)-framework involving CP and flavor violations (as in $\\mu \\to e\\gamma$, $\\tau \\to\\mu\\gamma$, edm's of the neutron and the electron) as well as proton decay are briefly mentioned. Recalling some of the successes we ...

  3. Grand Design Spiral Arms in A Young Forming Circumstellar Disk

    CERN Document Server

    Tomida, Kengo; Hosokawa, Takashi; Sakurai, Yuya; Lin, Chia Hui

    2016-01-01

    We study formation and long-term evolution of a circumstellar disk in a collapsing molecular cloud core using a resistive magnetohydrodynamic simulation. While the formed circumstellar disk is initially small, it grows as accretion continues and its radius becomes as large as 200 AUs toward the end of the Class-I phase. A pair of grand-design spiral arms form due to gravitational instability in the disk, and they transfer angular momentum in the highly resistive disk. Although the spiral arms disappear in a few rotations as expected in a classical theory, new spiral arms form recurrently as the disk soon becomes unstable again by gas accretion. Such recurrent spiral arms persist throughout the Class-0 and I phase. We then perform synthetic observations and compare our model with a recent high-resolution observation of a young stellar object Elias 2-27, whose circumstellar disk has grand design spiral arms. We find an excellent agreement between our theoretical model and the observation. Our model suggests tha...

  4. The influence of fluvial dynamics and North Atlantic swells on the beach habitat of leatherback turtles at Grande Riviere Trinidad.

    Science.gov (United States)

    Darsan, Junior; Jehu, Adam; Asmath, Hamish; Singh, Asha; Wilson, Matthew

    2016-09-15

    Grande Riviere beach, located on the north coast of Trinidad, West Indies, is internationally recognised as a critical habitat/nesting ground for the endangered leatherback turtles (Dermochelys coriacea). Episodic extreme flooding of the Grande Riviere River led to the shifting of the river mouth and resulted in backshore beach erosion, with the most recent recorded event occurring in 2012. Following this event, the construction of a sand dam to arrest further erosion which threatened coastal infrastructure, precipitated a host of new problems ranging from beach instability to public health threats. In January 2013, high energy swell waves naturally in-filled the erosion channel, and the beach recovery continued over the successive months, thereby rendering the intervention in the previous year questionable. This paper presents a geomorphological analysis of beach dynamics for Grande Riviere, within the context of this erosion event. Data on beach profiles, sediment and coastal processes were collected using standard geomorphological techniques. Beach topographic analysis and water quality tests on impounded water in the erosion channel were conducted. Results indicate that the event created an erosion channel of 4843.42 m(3) over a contiguous area of 2794.25 m(2). While swell waves were able to naturally infill the channel, they also eroded 17,762 m(3) of sand overall across the beach. Water quality tests revealed that the impounded water was classified as a pollutant, and created challenges for remediation. Hydrologic and coastal geomorphologic interplay is responsible for the existence and sustainability of this coastal system. It is also evident that the beach system is able to recover naturally following extreme events. Our results demonstrate that effective and integrated management of such critical habitats remains dependent upon continuous monitoring data which should be used to inform policy and decision making.

  5. Jeito de mulher rural: a busca de direitos sociais e da igualdade de gênero no Rio Grande do Sul The rural woman's way: the struggle for social rights and gender equality in Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Alie Van Der Schaaf

    2003-01-01

    Full Text Available Este trabalho trata de processos emancipatórios de mulheres, em especial de pequenas agricultoras no sul do Brasil, no Movimento de Mulheres Trabalhadoras Rurais do Rio Grande do Sul - MMTR-RS. A vida diária das agricultoras nos providencia elementos cruciais para entender a sua ação social, sendo o âmbito em que se produzem os significados culturais. Além disso, o enfoque na vida diária revela o impacto dos contextos históricos, econômicos, religiosos e políticos específicos em que a ação social acontece e nos ajuda a entender como as participantes chegam a problematizar demandas coletivas e a desafiar a arena política.This work approaches womens' emancipatory processes, specially those by small farmers in Southern Brazil, within the Rural Working Women's Movement of Rio Grande do Sul - MMTR-RS. Rural working women's daily life provide us with crucial elements to understand their social action, as the field in which they produce cultural meaning. Besides, the focus on daily life reveals the impact of historical, economical, religious and political contexts in which action develops, and helps us to understand how participants identify a set of problems as collective demands and challenge public arena.

  6. 78 FR 49296 - Centennial Challenges 2014 Sample Return Robot Challenge

    Science.gov (United States)

    2013-08-13

    ... SPACE ADMINISTRATION Centennial Challenges 2014 Sample Return Robot Challenge AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Notice of Centennial Challenges 2014 Sample Return Robot... Robot Challenge is scheduled and teams that wish to compete may register. Centennial Challenges is...

  7. National Drug IQ Challenge

    Science.gov (United States)

    ... Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2016 National Drug IQ Challenge ... Reto nacional del coeficiente intelectual (CI) sobre las drogas y el alcohol 2015 National Drug IQ Challenge ...

  8. Biomedical wellness challenges and opportunities

    Science.gov (United States)

    Tangney, John F.

    2012-06-01

    The mission of ONR's Human and Bioengineered Systems Division is to direct, plan, foster, and encourage Science and Technology in cognitive science, computational neuroscience, bioscience and bio-mimetic technology, social/organizational science, training, human factors, and decision making as related to future Naval needs. This paper highlights current programs that contribute to future biomedical wellness needs in context of humanitarian assistance and disaster relief. ONR supports fundamental research and related technology demonstrations in several related areas, including biometrics and human activity recognition; cognitive sciences; computational neurosciences and bio-robotics; human factors, organizational design and decision research; social, cultural and behavioral modeling; and training, education and human performance. In context of a possible future with automated casualty evacuation, elements of current science and technology programs are illustrated.

  9. The Backpack Design Challenge

    Science.gov (United States)

    Roman, Harry T.

    2010-01-01

    Something as simple as carrying books to school can be an interesting design challenge for students. It's an old problem that gets reinvented from time to time. In this article, the author discusses a backpack design challenge in which teachers work with students to design another way to carry books to school. The challenge started by trying to…

  10. Serologic response of Rio Grande wild turkeys to experimental infections of Mycoplasma gallisepticum.

    Science.gov (United States)

    Rocke, T E; Yuill, T M

    1988-10-01

    The serologic response of Rio Grande wild turkeys (Meleagris gallopavo intermedia) to Mycoplasma gallisepticum (MG) was determined. Free-ranging turkeys were caught in southern Texas, shipped to the University of Wisconsin, Madison, and housed in isolation facilities. Fourteen birds were exposed to MG, by intratracheal and intranasal inoculation. Eight birds received sterile broth only. Two wk prior to the end of the experiment, MG exposed turkeys were stressed by challenge with a serologically unrelated mycoplasma. Serum from all exposed birds reacted positively for MG antibody by the rapid plate agglutination (RPA) procedure within 2 mo postexposure (PE) and all but one remained positive for 14 mo PE. Less than one half of the exposed birds developed positive MG antibody titers detectable by the hemagglutination inhibition (HI) test within 2 mo PE, and by 10 mo PE, none had positive titers. Antibody was detected by the HI test in two of 11 infected turkeys, 14 mo PE, and titers increased significantly within 2 wk. MG was isolated from tracheal swabs from two infected birds 2 mo PE, but attempts thereafter failed. However, at the termination of the experiment 15 mo later, MG was isolated from lung tissue of three of 11 exposed turkeys and from a blood clot found in the lower trachea of one bird.

  11. Serologic response of Rio Grande wild turkeys to experimental infections of Mycoplasma gallisepticum

    Science.gov (United States)

    Rocke, Tonie E.; Yuill, Thomas M.

    1988-01-01

    The serologic response of Rio Grande wild turkeys (Meleagris gallopavo intermedia) to Mycoplasma gallisepticum (MG) was determined. Free-ranging turkeys were caught in southern Texas, shipped to the University of Wisconsin, Madison, and housed in isolation facilities. Fourteen birds were exposed to MG, by intratracheal and intranasal inoculation. Eight birds received sterile broth only. Two wk prior to the end of the experiment, MG exposed turkeys were stressed by challenge with a serologically unrelated mycoplasma. Serum from all exposed birds reacted positively for MG antibody by the rapid plate agglutination (RPA) procedure within 2 mo postexposure (PE) and all but one remained positive for 14 mo PE. Less than one half of the exposed birds developed positive MG antibody titers detectable by the hemagglutination inhibition (HI) test within 2 mo PE, and by 10 mo PE, none had positive titers. Antibody was detected by the HI test in two of 11 infected turkeys, 14 mo PE, and titers increased significantly within 2 wk. MG was isolated from tracheal swabs from two infected birds 2 mo PE, but attempts thereafter failed. However, at the termination of the experiment 15 mo later, MG was isolated from lung tissue of three of 11 exposed turkeys and from a blood clot found in the lower trachea of one bird.

  12. ‘Praise beyond Words’: Psalm 150 as grand finale of the crescendo in the Psalter

    Directory of Open Access Journals (Sweden)

    Dirk J. Human

    2011-06-01

    Full Text Available Without doubt the final hymn of the Psalter can be described as the climax, or grand finale, of the Israelite faith’s most known hymnbook. In this psalm, sound and action are blended into a picture of ecstatic joy. The whole universe is called upon to magnify Yah(weh, the God of Israel. The text poses various exegetical challenges. In the past, Psalm 150 was traditionally analysed as a single text; but with the advent of the canonical and redactionhistorical approaches to the interpretation of the Book of Psalms, Psalm 150 can be interpreted as part of the final Hallel (Pss 146–150, or Book V (Pss 107–150 of the Psalter. This view opens up new possibilities for reading the psalm in broader contexts and its broader literary context(s illuminate its theological significance. This article is an attempt at reflecting on the psalm’s context(s, structure, Gattung and dates of origin, tradition-historical relations to the Pentateuch, Psalms and other Old Testament texts. Ultimately some reflections on the psalm’s theological significance will be suggested.

  13. Towards omni-tomography--grand fusion of multiple modalities for simultaneous interior tomography.

    Directory of Open Access Journals (Sweden)

    Ge Wang

    Full Text Available We recently elevated interior tomography from its origin in computed tomography (CT to a general tomographic principle, and proved its validity for other tomographic modalities including SPECT, MRI, and others. Here we propose "omni-tomography", a novel concept for the grand fusion of multiple tomographic modalities for simultaneous data acquisition in a region of interest (ROI. Omni-tomography can be instrumental when physiological processes under investigation are multi-dimensional, multi-scale, multi-temporal and multi-parametric. Both preclinical and clinical studies now depend on in vivo tomography, often requiring separate evaluations by different imaging modalities. Over the past decade, two approaches have been used for multimodality fusion: Software based image registration and hybrid scanners such as PET-CT, PET-MRI, and SPECT-CT among others. While there are intrinsic limitations with both approaches, the main obstacle to the seamless fusion of multiple imaging modalities has been the bulkiness of each individual imager and the conflict of their physical (especially spatial requirements. To address this challenge, omni-tomography is now unveiled as an emerging direction for biomedical imaging and systems biomedicine.

  14. Reduced Resolution Groundwater Modeling in the Rio Grande for Real Time Scenario Evaluation

    Science.gov (United States)

    Roach, J. D.; Tidwell, V. C.

    2006-12-01

    As the finite, and often over-allocated water resources of the western United States are challenged by growing demands, computer based simulations can provide a powerful tool for evaluating potential water use scenarios in support of hydrologic decision making and water policy analysis. To represent the complexities of water resource management, a model should capture the salient behaviors and interactions between, the groundwater, surface water, and human behavioral systems, while to effectively connect science to the decision process, the model should run quickly enough to allow real time evaluation of a wide range of scenarios by stakeholders and decision makers themselves. As these potentially mutually exclusive objectives are pursued, the tradeoffs between resolution, run time, and the degree of coupling between modeled systems must be considered. In the Upper Rio Grande in New Mexico, three MODFLOW based, distributed groundwater models of the Espanola, Albuquerque, and Socorro groundwater basins have been used to calibrate a spatially simplified representation of the groundwater system in the region. The groundwater model is dynamically coupled to surface water and human behavioral systems as part of an integrated system dynamics based model which runs quickly enough to support rapid basin scale water policy scenario evaluation. This presentation will focus on development of the simplified groundwater model, and the performance tradeoffs and gains associated with spatial aggregation and dynamic coupling to the surface water system.

  15. Big Bologna. Le anomalie degli spazi pubblici in grande scala

    Directory of Open Access Journals (Sweden)

    Richard Ingersoll

    2013-06-01

    Full Text Available Nella periferia di Bologna sono nati recentemente nuovi spazi pubblici, molto diversi rispetto a quelli della città storica, che esprimono chiaramente  la mania della grandezza, la sindrome di Big Bologna. Ovunque si getta lo sguardo si notano nuove manifestazioni di una scala fuori proporzione che contribuisce alla segregazione sociale. Da quando sono arrivate le torri bianche della megastruttura di Kenzo Tange alla Fiera, la grande scala ha dato origine a spazi pubblici poco ameni per la vita urbana. Forse questi megaprogetti sono inevitabili segni dell’epoca della globalizzazione, ma ci si chiede se i committenti e i loro architetti sono stati consapevoli di quanto la progettazione di tali forme causa un deterrente alla socializzazione.

  16. Ethiopia's Grand Renaissance Dam: Implications for Downstream Riparian Countries

    Science.gov (United States)

    Zhang, Y.; Block, P. J.; Hammond, M.; King, A.

    2013-12-01

    Ethiopia has begun seriously developing their significant hydropower potential by launching construction of the Grand Ethiopian Renaissance Dam (GERD) on the Blue Nile River to facilitate local and regional growth. Although this has required substantial planning on Ethiopia's part, no policy dictating the reservoir filling rate strategy has been publicly issued. This filling stage will have clear implications on downstream flows in Sudan and Egypt, complicated by evaporative losses, climate variability, and climate change. In this study, various filling policies and future climate states are simultaneously explored to infer potential streamflow reductions at Lake Nasser, providing regional decision-makers with a set of plausible, justifiable, and comparable outcomes. Schematic of the model framework Box plots of 2017-2032 percent change in annual average streamflow at Lake Nasser for each filling policy constructed from the 100 time-series and weighted precipitation changes. All values are relative to the no dam policy and no changes to future precipitation.

  17. The grand partition function of dilute biregular solutions

    Science.gov (United States)

    Nagamori, Meguru; Ito, Kimihisa; Tokuda, Motonori

    1994-10-01

    It has been demonstrated that the grand partition function (GPF) of biregular solutions contains in one single equation such thermodynamic principles as Henry's law, Raoult's law, the Gibbs-Duhem relation, Raoultian activity coefficients and their finite power series, Wagner's rec-iprocity, Schenck-Frohberg-Steinmetz's interchange, Lupis-Elliott's additivity, Mori-Morooka's disparity, and Darken's quadratic formalism. The logarithm of the Raoultian activity coefficient of species i, In γi should not be expressed by the Taylor series expansion, lest its truncation infringe the Gibbs-Duhem equation. The GPF methodology establishes that In γi, is not a vector but a scalar point function, free from any path dependence. While Darken's quadratic formalism employs three parameters to describe a ternary solution, the present biregularity approximation offers an alternative using seven empirical parameters, in case better accuracy is needed.

  18. Organización de grandes eventos deportivos internacionales

    Directory of Open Access Journals (Sweden)

    Añó Sanz, Vicente

    2000-02-01

    Full Text Available Not available

    El deporte moderno ha evolucionado sustancialmente en los últimos años, principalmente en los aspectos económicos y organizativos. La clave para ello ha sido la gran demanda de los ciudadanos hacia el mismo. Ello ha provocado su comercialización y la organización de grandes acontecimientos deportivos, que como los JJOO o los Campeonatos del Mundo, obligan a crear modelos de organización en los que se distribuyen las áreas de trabajo para resolver las tareas que se plantean, como los transportes y alojamientos de la gran cantidad de personas que acuden, los aspectos técnicos deportivos, los medios materiales, los recursos humanos, etc.

  19. From Grand Narratives of Democracy to Small Expectations of Participation

    DEFF Research Database (Denmark)

    Peters, Christopher; Witschge, Tamara

    2016-01-01

    representative, mediation for political actors), we compare and contrast conceptualisations of the audience found within these and discuss how digital technologies impact these relationships. We consider how “participatory” transformations influence perceptions of news consumption and draw out analytic......This chapter critically examines the invocation of democracy in the discourse of audience participation in digital journalism. Rather than simply restate the familiar grand narratives that traditionally described journalism’s function for democracy (information source, watchdog, public...... we distinguish between minimalist and maximalist versions of participation through interactive tools, as there is a significant distinction between technologies that allow individuals to control and personalise content (basic digital control) and entire platforms that easily facilitate...

  20. A Graphical representation of the grand canonical partition function

    CERN Document Server

    Smii, Boubaker

    2010-01-01

    In this paper we consider a stochastic partial differential equation defined on a Lattice $L_\\delta$ with coefficients of non-linearity with degree $p$. An analytic solution in the sense of formal power series is given. The obtained series can be re-expressed in terms of rooted trees with two types of leaves. Under the use of the so-called Cole-Hopf transformation and for the particular case $p=2$, one thus get the generalized Burger equation. A graphical representation of the solution and its logarithm is done in this paper. A discussion of the summability of the previous formal solutions is done in this paper using Borel sum. A graphical calculus of the correlation function is given. The special case when the noise is of L\\'evy type gives a simplified representations of the solution of the generalized Burger equation. From the previous results we recall a graphical representation of the grand canonical partition function.

  1. Testing Grand Unification at the (S)LHC

    CERN Document Server

    Rainwater, D L

    2007-01-01

    We examine the possibility of measuring the three gauge couplings at high scales at the LHC, in order to see the first steps as they run toward Grand Unification at much higher energies. Using the MSSM with sparticle masses of several hundred GeV as an example of a theory in which the couplings do unify at very high energies, we find that the processes pp->lv, pp->l+l- and pp->gamma+j can be useful to discriminate the SM from the MSSM with masses at the few hundred GeV scale, and determine that the couplings are converging at better than the SM prediction toward the GUT scale. Such measurements indirectly probe the existence of lower mass states, charged under the SM gauge groups, but which may be difficult to produce directly or extract from backgrounds at the LHC.

  2. Grande Ronde Basin Fish Habitat Enhancement Project : 2007 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    McGowan, Vance R.; Morton, Winston H.

    2008-12-30

    On July 1, 1984 the Bonneville Power Administration and the Oregon Department of Fish and Wildlife entered into an intergovernmental contract to initiate fish habitat enhancement work in the Joseph Creek subbasin of the Grande Ronde River Basin in northeast Oregon. In 1985 the Upper and Middle Grande Ronde River, and Catherine Creek subbasins were included in the contract, and in 1996 the Wallowa River subbasin was added. The primary goal of 'The Grande Ronde Basin Fish Habitat Enhancement Project' is to create, protect, and restore riparian and instream habitat for anadromous salmonids, thereby maximizing opportunities for natural fish production within the basin. This project provided for implementation of Program Measure 703 (C)(1), Action Item 4.2 of the Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program (NPPC, 1987), and continues to be implemented as offsite mitigation for mainstem fishery losses caused by the Columbia River hydro-electric system. All work conducted by the Oregon Department of Fish and Wildlife and partners is on private lands and therefore requires that considerable time be spent developing rapport with landowners to gain acceptance of, and continued cooperation with this program throughout 10-15 year lease periods. Both passive and active restoration treatment techniques are used. Passive regeneration of habitat, using riparian exclosure fencing and alternate water sources are the primary method to restore degraded streams when restoration can be achieved primarily through changes in management. Active restoration techniques using plantings, bioengineering, site-specific instream structures, or whole stream channel alterations are utilized when streams are more severely degraded and not likely to recover in a reasonable timeframe. Individual projects contribute to and complement ecosystem and basin-wide watershed restoration efforts that are underway by state, federal, and tribal agencies, and

  3. Climate Change Impacts in the Upper Rio Grande Catchment

    Science.gov (United States)

    Heikkila, T.; Siegfried, T. U.; Sellars, S. L.; Schlager, E.

    2010-12-01

    In the US Southwest, evidence of increased future drought severity and duration in the context of climate change has been detected. Considering the already difficult water distribution and allocation strategies within the region, we are investigating the Costilla Creek, a tributary to the Rio Grande. The catchment is located in Costilla county in Colorado from where on runoff is crossing boundaries between Colorado and New Mexico three times before its confluence with the Rio Grande in New Mexico. Water allocation is governed by an interstate compact between Colorado and New Mexico. While the states have been relatively successful in complying with the compact’s allocation rules, the Costilla Creek catchment has experienced interstate upstream/downstream conflict, mainly during irrigation seasons. Whether or not the states will be able to avert conflict in the future and maintain compliance with the compact, is a critical question. The situation in the relatively small catchment is not unique. Various interstate watersheds, including the entire Rio Grande basin, the La Plata, Arkansas, and Colorado, are expected to face similar impacts from climate change, yet the water compacts that govern them may not be structured to adapt to these conditions. Looking at the Costilla Creek offers a valuable starting point for understanding how to model these effects across various basins. We have developed a lumped-parameter rainfall-runoff model including snow storage of the Costilla Creek watershed. Temperature and precipitation data from NCRS - SNOTEL stations together with USGS gauging station data were utilized for model calibration and validation. ISCCP solar radiation data and temperature data were used to estimate irrigation water demand in irrigated agriculture. The model is driven by the IPCC SRES A2 scenario. GCM ensemble averaged temperature / precipitation trends were extracted for the upper Rio Grande region. 50 year precipitation simulations were created using a

  4. SO(10) grand unification in a fuzzy setting

    Energy Technology Data Exchange (ETDEWEB)

    El Naschie, M.S. [King Abdul Aziz City of Science and Technology, Riyadh (Saudi Arabia)

    2007-05-15

    While the SU (5) unification is controlled by vertical bar SU(5) vertical bar = 24 charges, the SO(10) grand unification possesses vertical bar SO(10) vertical bar = 45 charges. The present work gives a partial reformulation of SO(10) unification in a fuzzy setting. In particular, it is argued that the geometrical picture behind the {l_brace}126{r_brace} representation of SO(10) is identical to the structure behind E-infinity and the transfinite E {sub 8} - E {sub 8} exceptional Lie group when we continue {l_brace}126{r_brace} transfinitely. It is conjectured that within the fuzzy setting, SU(5) and SO(10) are essentially various homeomorphisms approximating E-infinity theory.

  5. Brasil – Estados Unidos: grandes expectativas, pequenos atritos

    Directory of Open Access Journals (Sweden)

    Virgílio Caixeta Arraes

    2016-12-01

    Full Text Available O princípio da administração de Barack Obama, do Partido Democrata, gerou expectativa positiva na América Latina, região desdenhada pelo antecessor, George Bush, do Partido Republicano. Valorizar o continente seria prestigiar o Brasil. Todavia, o relacionamento não foi o esperado, embora sem grandes decepções também. The beginning of Barack Obama´s term produced positive expectations on Latin America, a continent which was ignored by his predecessor, George Bush. To give attention to Latin America implies giving prestige to Brazil.  Nonetheless the real relationship could not meet the expectations, although without causing great deceptions.

  6. Dawn Grand Map Vesta Neutron Absorption V1.0

    Science.gov (United States)

    Prettyman, T. H.

    2014-06-01

    A global map of a unitless compositional parameter, delta-C_perpendicular (DCP), and propagated 1-sigma uncertainties is provided. DCP varies linearly with the macroscopic thermal neutron absorption cross section of Vesta's regolith. An equation for converting tabulated DCP values to absorption units is provided in this document. DCP was determined from thermal and epithermal neutron counting rates measured by the NASA Dawn mission's Gamma Ray and Neutron Detector (GRaND) while in low altitude mapping orbit, about 210 km from Vesta's surface. The measurements are representative of Vesta's bulk regolith composition to depths of a few decimeters with a spatial resolution of about 300-km full-width-at-half-maximum of arc length on the surface. The methods used to determine neutron absorption are described by PRETTYMANETAL2013.

  7. Percepção dos trabalhadores avulsos sobre os riscos ocupacionais no porto do Rio Grande, Rio Grande do Sul, Brasil Temporary workers' perceptions of occupational risks in the port of Rio Grande, Rio Grande do Sul State, Brazil

    Directory of Open Access Journals (Sweden)

    Jorgana Fernanda de Souza Soares

    2008-06-01

    Full Text Available Este é um estudo transversal, descritivo, com abordagem quantitativa, realizado no porto do Rio Grande, Rio Grande do Sul, Brasil e objetivou identificar a percepção, em uma amostra com 306 trabalhadores portuários avulsos, sobre risco à saúde no trabalho. A maioria dos trabalhadores portuários avulsos (93,46% reconheceu que existem riscos à sua saúde no trabalho e isso foi independente do grau de instrução (p = 0,44, atividade desenvolvida (p = 0,47. Os riscos identificados no grupo geral de trabalhadores portuários avulsos foram queda de objetos suspensos (8,43 ± 2,47, ruídos (8,06 ± 2,32 e intempéries (8,05 ± 2,48. Os riscos significativamente diferentes entre as atividades foram: ruídos (p = 0,00, levantamento manual de carga (p = 0,00, ferramentas de trabalho (p = 0,00, componentes dos ternos em número abaixo do ideal (p = 0,03, ganho por produtividade (p = 0,00, ritmo de trabalho (p = 0,01, trabalho em altura (p = 0,00, deslocamento do trabalhador sobre as cargas (p = 0,00, escadas de acesso às embarcações (p = 0,00. Pode-se corroborar que o trabalho portuário avulso é insalubre e perigoso, e os riscos se apresentam aos trabalhadores em consonância com a atividade por eles desenvolvida.This was a cross-sectional, descriptive, quantitative study in the port of Rio Grande, Rio Grande do Sul, Brazil, aimed at identifying occupational risk perceptions in a sample of 306 temporary dockworkers. Most temporary dockworkers (93.46% acknowledged the existence of health risks on the job, independently of schooling (p = 0.44 and job activity (p = 0.47. Risks identified by temporary workers as a whole included falling of suspended objects (8.43 ± 2.47, noise (8.06 ± 2.32, and bad weather conditions (8.05 ± 2.48. Risks that varied significantly between jobs were: noise (p = 0.00, lifting loads manually (p = 0.00, work tools (p = 0,00, insufficient number of work team members (p = 0.03, extra wages based on productivity (p = 0

  8. Sensitivity of KASCADE-Grande data to hadronic interaction models

    CERN Document Server

    Kang, D; Arteaga-Velázquez, J C; Bekk, K; Bertaina, M; Blümer, J; Bozdog, H; Brancus, I M; Buchholz, P; Cantoni, E; Chiavassa, A; Cossavella, F; Daumiller, K; de Souza, V; di Pierro, F; Doll, P; Engel, R; Engler, J; Finger, M; Fuhrmann, D; Ghia, P L; Gils, H J; Glasstetter, R; Grupen, C; Haungs, A; Heck, D; Hörandel, J R; Huege, T; Isar, P G; Kampert, K -H; Kickelbick, D; Klages, H O; Link, K; Luczak, P; Ludwig, M; Mathes, H J; Mayer, H J; Melissas, M; Milke, J; Mitrica, B; Morello, C; Navarra, G; Nehls, S; Oehlschläger, J; Ostapchenko, S; Over, S; Palmieria, N; Petcu, M; Pierog, T; Rebel, H; Roth, M; Schieler, H; Schröder, F G; Sima, O; Toma, G; Trinchero, G C; Ulrich, H; Weindl, A; Wochele, J; Wommer, M; Zabierowski, J

    2010-01-01

    KASCADE-Grande is a large detector array dedicated for studies of high-energy cosmic rays in the primary energy range from 100 TeV to 1 EeV. The multi-detector concept of the experimental set-up offers the possibility to measure simultaneously various observables related to the electromagnetic, muonic, and hadronic air shower components. The experimental data are compared to predictions of CORSIKA simulations using high-energy hadronic interaction models (e.g. QGSJET or EPOS), as well as low-energy interaction models (e.g. FLUKA or GHEISHA). This contribution will summarize the results of such investigations. In particular, the validity of the new EPOS version 1.99 for EAS with energy around 100 PeV will be discussed.

  9. An SU(5) grand unified model with discrete flavour symmetries

    CERN Document Server

    Hernández, A E Cárcamo; Schmidt, Iván

    2014-01-01

    We propose a model based on the $SU(5)$ grand unification with an extra $Z_{2}\\otimes Z_{2}^{\\prime}\\otimes Z_{2}^{\\prime \\prime}\\otimes Z_{4}\\otimes Z_{12}$ flavor symmetry, which successfully describes the observed SM fermion mass and mixing pattern. The observed quark mass and mixing pattern is caused by the $Z_{4}$ and $Z_{12}$ symmetries, which are broken at very high scale by the $SU(5)$ scalar singlets $\\sigma $ and $\\chi $, charged respectively under these symmetries and which acquire VEVs at the GUT scale. The light neutrino masses are generated via a type I seesaw mechanism with three heavy Majorana neutrinos. The model has in total 17 effective free parameters, from which 2 are fixed and 15 are fitted to reproduce the experimental values of the 18 physical parameters in the quark and lepton sectors. The model predictions for both quark and lepton sectors are in excellent agreement with the experimental data.

  10. A grande aceleração & o campo comunicacional

    Directory of Open Access Journals (Sweden)

    Lucia Santaella

    2015-12-01

    Full Text Available Desde a revolução industrial que inaugurou, no campo da comunicação, a era da reprodutibilidade técnica, novas tecnologias midiáticas não cessam de emergir em um ritmo cada vez mais intenso até se tornar verdadeiramente avassalador a partir do advento do universo digital. Essa emergência crescente de tecnologias midiáticas não é um fenômeno isolado, mas deve ser inserida no contexto bem mais amplo daquilo que os especialistas em mudanças climáticas e geologia estão chamando de “grande aceleração”. Para realizar tal inserção, este artigo tomou como roteiro metodológico o levantamento e estudo de dados bibliográficos, de um lado, relativos à evolução midiática desde a revolução industrial no século XIX até os nossos dias. De outro lado, relativos ao crescimento desmedido do gasto de fontes energéticas do planeta inteiramente imerso na circulação perversa do mercado capitalista. A comparação entre os dados tanto de um quanto de outro lado, conduziu esta pesquisa à constatação de uma interrelação indissolúvel entre ambos. Esse percurso nos leva à conclusão de que a aceleração midiática é parte integrante e contribui a seu modo para a grande aceleração que está levando o planeta Terra a uma nova era geológica.

  11. Web-based Interactive Landform Simulation Model - Grand Canyon

    Science.gov (United States)

    Luo, W.; Pelletier, J. D.; Duffin, K.; Ormand, C. J.; Hung, W.; Iverson, E. A.; Shernoff, D.; Zhai, X.; Chowdary, A.

    2013-12-01

    Earth science educators need interactive tools to engage and enable students to better understand how Earth systems work over geologic time scales. The evolution of landforms is ripe for interactive, inquiry-based learning exercises because landforms exist all around us. The Web-based Interactive Landform Simulation Model - Grand Canyon (WILSIM-GC, http://serc.carleton.edu/landform/) is a continuation and upgrade of the simple cellular automata (CA) rule-based model (WILSIM-CA, http://www.niu.edu/landform/) that can be accessed from anywhere with an Internet connection. Major improvements in WILSIM-GC include adopting a physically based model and the latest Java technology. The physically based model is incorporated to illustrate the fluvial processes involved in land-sculpting pertaining to the development and evolution of one of the most famous landforms on Earth: the Grand Canyon. It is hoped that this focus on a famous and specific landscape will attract greater student interest and provide opportunities for students to learn not only how different processes interact to form the landform we observe today, but also how models and data are used together to enhance our understanding of the processes involved. The latest development in Java technology (such as Java OpenGL for access to ubiquitous fast graphics hardware, Trusted Applet for file input and output, and multithreaded ability to take advantage of modern multi-core CPUs) are incorporated into building WILSIM-GC and active, standards-aligned curricula materials guided by educational psychology theory on science learning will be developed to accompany the model. This project is funded NSF-TUES program.

  12. Along the Grand Trunk Road: The Photography of Raghubir Singh

    Directory of Open Access Journals (Sweden)

    Chaya Chandrasekhar

    2013-05-01

    Full Text Available For more than two millennia, the historic Grand Trunk Road, the busy thoroughfare that extends some 1500 miles through north India and Pakistan served as the main artery of South Asia. It was also the gateway through which waves of immigrants, travelers, and invaders entered the subcontinent. As a result, a great deal of diversity and tolerance marks the road. Between 1988 and 1991, Raghubir Singh (1942-1999, one of India’s renowned documentary photographers, traveled and photographed the Indian stretch of the Road. Ninety-six photographs from his journeys appear in the publication, 'The Grand Trunk Road: A Passage Through India '(1995. Singh used the pictorial style of street photography that he is known for to capture everyday life along the path. Further, he emphasized the tremendous diversity he witnessed along the road through the selections he made for inclusion in the book and the specific manner in which he arranged many of them. By underscoring the heterogeneity, Singh provided a critical visual commentary of the political climate in India during the 1980s and early nineties. This period coincided with the rise of Hindu nationalism, which aimed to erase the subcontinent’s diverse past and promote instead the idea of a homogenous/Hindu India. By documenting the road in his uniquely pictorial style and arranging the photographs in his book to draw attention to the differences and tolerance witnessed along the path, Singh demonstrated that India was not a monolithic culture as the politics of the time claimed, but a rich interwoven fabric of many varied strands.

  13. Fatores associados ao atraso no desenvolvimento em crianças, Rio Grande, Rio Grande do Sul, Brasil Factores asociados con retraso en el desarrollo de los niños, Rio Grande, Rio Grande do Sul, Brasil Factors associated with delay in development in children, Rio Grande, Rio Grande do Sul, Brazil

    Directory of Open Access Journals (Sweden)

    Aline Alves Veleda

    2011-03-01

    Full Text Available Estudo analítico com o objetivo de avaliar os fatores associados ao atraso no desenvolvimento em crianças entre 8 a 12 meses de idade indicadas como de risco ao nascer no município do Rio Grande, Rio Grande do Sul, Brasil. Foram utilizados como instrumentos o Teste de Triagem de Desenvolvimento de Denver II (TTDD II, a avaliação antropométrica e questionários estruturados. Participaram 220 crianças consideradas de risco ou não ao nascer. Foi encontrada uma prevalência de 20,5% de suspeita de atraso no desenvolvimento neuropsicomotor. As crianças que apresentaram risco de um TTDD II suspeito faziam parte de famílias de mais baixa renda; eram filhos de mães que haviam realizado menos de seis consultas de pré-natal e apresentavam índice peso-idade inadequado. Os dados sugerem a necessidade de um replanejamento das políticas de saúde infantil, visto que outros critérios poderiam ser incluídos nas condições de risco para a criança ao nascer.Estudio analítico con el objetivo de evaluar los factores asociados al atraso en el desarrollo en niños de 8 a 12 meses de edad indicados como riesgo al nacer en el municipio de Rio Grande, RS, Brasil. Fueron utilizadas como herramientas la Prueba de Tamizaje del Desarrollo de Denver II, la evaluación antropométrica y cuestionarios estructurados. Participaron 220 niños considerados de riesgo o no al nacer. Fue encontrada una prevalencia del 20,5% de sospecha de atraso en el desarrollo neuropsicomotor. Los niños que presentaron riesgo de un DDST II sospechoso formaban parte de familias de más baja renta; eran hijos de madres que habían realizado menos de seis consultas de prenatal y presentaban índice peso-edad inadecuado. Los datos sugieren la necesidad de un replanteamiento de las políticas de salud infantil, así como otros criterios podrían ser inclusos en las condiciones de riesgo para el niño al nacer.This analytical study aims to evaluate the factors associated to

  14. 75 FR 36673 - Notice of Inventory Completion: Public Museum of West Michigan, Grand Rapids, MI

    Science.gov (United States)

    2010-06-28

    ... following non-federally recognized Indian groups: Burt Lake Band of Ottawa & Chippewa and the Grand River... individual was identified. The 11 associated funerary objects are 1 lot of woven fiber fragments, 1 lot of... as the Grand River Band of Ottawa Indians, a non-federally recognized tribe, because the...

  15. 40 CFR 81.239 - Upper Rio Grande Valley Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Air Quality Control Regions § 81.239 Upper Rio Grande Valley Intrastate Air Quality Control Region. The Upper Rio Grande Valley Intrastate Air Quality Control Region (New Mexico) consists of the... Quality Control Region. 81.239 Section 81.239 Protection of Environment ENVIRONMENTAL PROTECTION...

  16. 40 CFR 81.83 - Albuquerque-Mid Rio Grande Intrastate Air Quality Control Region.

    Science.gov (United States)

    2010-07-01

    ... Designation of Air Quality Control Regions § 81.83 Albuquerque-Mid Rio Grande Intrastate Air Quality Control Region. The Albuquerque-Mid Rio Grande Intrastate Air Quality Control Region (New Mexico) is revised to... Air Quality Control Region. 81.83 Section 81.83 Protection of Environment ENVIRONMENTAL...

  17. Cent’anni dopo: la Grande Guerra e la cultura politica britannica

    Directory of Open Access Journals (Sweden)

    Maria Chiara Pievatolo

    2014-12-01

    Full Text Available Claudio Palazzolo ha scelto di pubblicare ad accesso aperto il suo intervento al convegno L’Italia e l’Europa di fronte alla Grande Guerra, dedicato a La Grande Guerra e la cultura politica britannica. Il suo testo, depositato nell’archivio Marini, è a...

  18. A study of the Forbush decrease event of September 11, 2005 with GRAND

    OpenAIRE

    Poirier, J; Herrera, M.; Hemphill, P.; D'Andrea, C.

    2008-01-01

    Project GRAND, a proportional wire chamber array, is used to examine the decreased counting rate of ground level muons during the Forbush decrease event of September 11, 2005. Data are presented and compared to that of other cosmic ray monitors. A directional study of the Forbush decrease was undertaken and precursor anisotropies to this geomagnetic storm were studied utilizing GRAND's angular resolution.

  19. 78 FR 73559 - Moose-Wilson Corridor Comprehensive Management Plan, Environmental Impact Statement, Grand Teton...

    Science.gov (United States)

    2013-12-06

    ... National Park Service Moose-Wilson Corridor Comprehensive Management Plan, Environmental Impact Statement... the Moose-Wilson Corridor, Grand Teton National Park, Wyoming. DATES: The National Park Service will...://parkplanning.nps.gov/MooseWilson , at the Grand Teton National Park Headquarters Building, 1 Teton Park...

  20. 78 FR 45495 - Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation Management...

    Science.gov (United States)

    2013-07-29

    ... Forest Service Conejos Peak Ranger District, Rio Grande National Forest; Colorado; Cumbres Vegetation... statement. SUMMARY: The Conejos Peak Ranger District, Rio Grande National Forest, proposes to salvage timber... comments-rockv-mountain-rio-qrande-conejos-peak@fs.fed.us , or via facsimile to 719-852-6250, with...