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Sample records for biopsia transrectal ecodirigida

  1. Estudo comparativo entre três técnicas de anestesia geral para biópsia de próstata dirigida por ultrassonografia transretal Estudio comparativo entre tres técnicas de anestesia general para biopsia de próstata dirigida por ultrasonido transrectal A comparative study among three techniques of general anesthesia for ultrasound-guided transrectal prostate biopsy

    Directory of Open Access Journals (Sweden)

    Ricardo Antônio Guimarães Barbosa

    2010-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A biópsia de próstata dirigida por ultrassonografia transretal constitui referência no diagnóstico das neoplasias da próstata. Quanto maior o número de amostras colhidas, maiores a dor e o desconforto relatados pelo paciente. O objetivo do estudo foi comparar três técnicas anestésicas neste grupo de pacientes. MÉTODO: Foram estudados 45 pacientes separados em três grupos: 1 - Propofol; 2 - Propofol + Bloqueio de Plexo Prostático; 3 - Propofol + Fentanil. Os pacientes foram monitorados com pressão arterial não invasiva, eletrocardioscopia contínua, oximetria de pulso (SpO2 e Índice Bispectral. Não receberam medicação pré-anestésica. Foram avaliados os parâmetros hemodinâmicos no intra e pós-operatório, Índice bispectral no intraoperatório, avaliação da dor pela escala numérica verbal (ENV no pós-operatório imediato e uso de dipirona como tratamento da dor pós-operatória. RESULTADOS: Não houve diferença significativa entre os três grupos: variáveis antropométricas, quantidade de propofol, número de fragmentos e tempo do exame. Os parâmetros hemodinâmicos e a SpO2 apresentaram comportamento semelhante nos três grupos durante o estudo. No grupo 1, a dor avaliada pela ENV foi mais elevada e houve maior necessidade de dipirona que nos outros grupos. CONCLUSÕES: Sedação com propofol isolado para biópsia causa maior dor e desconforto pós-operatório do que quando associado a bloqueio do plexo prostático ou a fentanil sistêmico. Além de hipnose, é necessária a realização de analgesia intraoperatória para garantir conforto pósoperatórioJUSTIFICATIVA Y OBJETIVOS: La biopsia de próstata dirigida por ultrasonido transrectal constituye una referencia en el diagnóstico de las neoplasias de la próstata. Mientras mayor es el número de muestras escogidas, mayores son el dolor y la incomodidad relatados por el paciente. El objetivo del estudio fue comparar tres técnicas anest

  2. BIOPSIA ENDOMETRIAL AMBULATORIA: EXPERIENCIA PRELIMINAR

    OpenAIRE

    Domínguez C,Claudio; Zamora F,Jessica; Barrera P,Sandra; Tacla F,Ximena

    2006-01-01

    Objetivo: Presentar la experiencia inicial en el diagnóstico histológico con biopsia endometrial ambulatoria obtenida con pipelle de Cornier. Material y método: Se efectuó biopsia endometrial ambulatoria con pipelle de Cornier en 144 pacientes con sospecha clínica y/o ecográfica de patología endometrial difusa. Resultados: Se logró realizar el procedimiento a 131 pacientes (91%), obteniéndose diagnóstico histológico satisfactorio en 110 casos (76,4%). De las 110 muestras analizadas, se diagno...

  3. Prostatic biopsy in the prostate specific antigen gray zone; La biopsia prostatica multipla nalla zona grigia dei valori dell'antigene prostatico specifico

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    Drudi, F. M.; Ricci, P.; Iannicelli, E.; Di Nardo, R.; Novelli, L.; Laghi, A.; Passariello, R. [Rome Univ. La Sapienza, Rome (Italy). Ist. di Radiologia II Cattedra; Perugia, G. [Rome Univ. La Sapienza, Rome (Italy). Dipt. di Urologia U. Bracci

    2000-02-01

    The main purpose of this study was to identify cases of undetected prostatic cancer in patients with normal findings at digital examination and transrectal US, and prostate specific antigen (PSA) values ranging 4-10 ng/mL. 290 patients were submitted to transrectal US and random bilateral prostatic biopsy; 3 samples were collected from each side of the gland using 16-Gauge thru-cut needles. Of the 290 patients who gave full informed consent, 34 people were selected whose age range was between 56 to 76 years (mean: 64). Inclusion criteria were PSA 4-10 ng/mL, PSAD cut-off 0.15, free/total PSA ratio 15-25%, and normal findings at digital examination and transrectal US. PSA velocity was calculated collecting 3 blood samples every 30 days for 2 months. 5 of the 34 selected patients (15%) had prostatic cancer, and 2 (6%) Pin (1 Pin 1 and 1 Pin 2). As for the other 27 patients, biopsy demonstrated 4 (12%) cases of prostatitis and 23 (62%) cases of BPH. PSA values increased in all patients with positive histology, versus only 6 (22%) of those with negative histology. Our findings confirm that prostatic biopsy can detect tumors also in areas which appear normal at transrectal US and digital examination, and that PSA rate increases in patients with positive histology. Finally, the actual clinical role of prostatic biopsy relative to all other diagnostic imaging techniques remains to be defined. [Italian] Si intende qui dimostrare la percentuale di neoplasie prostatiche sfuggite all'esplorazione rettale e all'ecografia transrettale nei pazienti convalori di antigene prostatico specifico tra 4 e 10 ng/ml. 290 pazienti sono stati sottoposti a ecografia transrettale e biopsia multipla (6 prelievi, ago da 16 Gauge) dopo consenso informato. Di questi sono stati selezionati 34: eta' tra 56 e 76 anni, eta' media 64 anni. Parametri di selezione: antigene prostatico specifico con valori tra 4 e 10ng/ml; densita' dell'antigene prostatico specifico con

  4. [Intrarectal povidone-iodine to reduce the risk of genitourinary infections after transrectal prostate biopsy].

    Science.gov (United States)

    Moreno-Palacios, Jorge; Espinosa-Guerrero, Alejandro; Torres-Anguiano, Juan Ramón; Montoya-Martínez, Guillermo; López-Samano, Virgilio; Serrano-Brambila, Eduardo

    2015-01-01

    Introducción: el objetivo de este estudio es comparar dos preparaciones distintas en pacientes sometidos a la toma de biopsias prostáticas transrectales (BPTR) y evaluar la prevalencia de infecciones genitourinarias (IGU). Métodos: se compararon dos grupos de pacientes con sospecha de cáncer de próstata sometidos a Biopsia Prostática Transrectal (BPTR): Con jalea lubricante endorrectal (grupo l, cohorte histórica) y con jalea lubricante más iodopovidona (grupo II, cohorte prospectiva). Se evaluaron las complicaciones a las tres semanas. Se realizó un análisis bivariado, calculando su OR (IC: 95 %) para determinar si la iodopovidona endorrectal adicional previa a la BPTR disminuye las IGU y otras complicaciones. Resultados: Se evaluaron 185 pacientes (Grupo I n = 86; grupo II n = 96). Tuvieron infección del tracto genitourinario el 45 y 25 % (OR: 0.4, IC: 0.2-0.9, p = 0.004); la fiebre se presentó en el 21 y 10 % respectivamente (OR: 0.42, IC: 0.1-0.9, p = 0.04). Conclusiones: Se observó una reducción en la presencia de infecciones genitourinarias en pacientes a quienes se aplicó en su preparación iodopovidona intrarrectal.

  5. Aportaciones de la biopsia muscular al entrenamiento deportivo

    OpenAIRE

    Subiela, J.V.; Torres, S.H.

    2010-01-01

    La biopsia muscular por aguja es una técnica bastante asequible, que ha permitido conocer las características de los diferentes tipos de fibras del músculo esquelético, su potencial metabólico y su gran capacidad de adaptación a los distintos estímulos de entrenamiento. Aunque el modelo de distribución de las fibras en los distintos músculos parece estar determinado genéticamente, se ha observado la transformación reversible de los tipos de fibras pertenecientes a un mismo músculo, inducida por ...

  6. Transrectal Drainage of Deep Pelvic Abscesses Using a Combined Transrectal Sonographic and Fluoroscopic Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Kyung Soon; Lee, Eun Jung; Ko, Ji Ho; Joh, Young Duk [Gospel Hospital, Kosin University College of Medicine, Busan (Korea, Republic of); Jung, Gyoo Sik [Ulsan Hospital, Ulsan (Korea, Republic of)

    2005-09-15

    To evaluate the feasibility and clinical efficacy of transrectal drainage of a deep pelvic abscess using combined transrectal sonographic and fluoroscopic guidance. From March 1995 and August 2004, 17 patients (9 men; 8 women; mean age, 39 years) suffering from pelvic pain, fever and leukocytosis were enrolled in this retrospective study. Ultrasound (US) or computed tomography (CT), which was obtained prior to the procedure, showed pelvic fluid collections that were deemed unapproachable by the percutaneous trans abdominal routes. Transrectal drainage of the pelvic abscess was performed under combined transrectal sonographic and fluoroscopic guidance. The causes of the deep pelvic abscess were postoperative complications (n=7), complications associated with radiation (n=3) and chemotherapy (n=1) as well as unknown causes (n=6). A 7.5-MHz end-firing transrectal US probe with a needle biopsy guide attachment was advanced into the rectum. Once the abscess was identified, a needle was advanced via the biopsy guide and the abscess was punctured. Under US guidance, either a 0.018'or 0.035' guide wire was passed through the needle in the abscess. Under fluoroscopic guidance, the tract was dilated to the appropriate diameter with sequential fascial dilators, and a catheter was placed over the guide wire within the abscess. Clinical success of drainage was determined by a combination closure of the cavity on the follow up images and diminished leukocytosis. The technical and clinical success rate, complications, and patient's discomfort were analyzed. Drainage was technically successful in all patients and there were no serious complications. Surgery was eventually performed in two cases due to fistular formation with the rectum and leakage of the anastomosis site. The procedure was well tolerated in all but one patient who complained of discomfort while the catheter was inserted . The catheter did not interfere with defecation and there was no incidence of

  7. Biopsia de la próstata, aspiración con aguja fina

    OpenAIRE

    Gómez Lloreda, Eugenio; Chavarro Porras, Jorge; Martínez Garzón, Miguel

    2012-01-01

    Se presentan los resultados preliminares de biopsia por punción con aguja tina de la próstata en cuanto a su tolerancia por parte de los pacientes, su fácil manejo por parte del urólogo y su interpretación desde el punto de vista histopatológico. Los resultados comparativos entre la biopsia por punción con aguja fina y la biopsia con Tru-Cut son similares en cuanto a la certeza en el diagnóstico del cáncer de próstata, pero las complicaciones médicas son mucho menores en la biopsia por punció...

  8. Biopsia Renal en receptores de Trasplante Renal: cuidados de enfermería y complicaciones

    Directory of Open Access Journals (Sweden)

    Esther Sanz Izquierdo

    Full Text Available Introducción: La biopsia renal percutánea es una herramienta fundamental para el manejo del paciente trasplantado renal. La prueba es primordial para detectar y/o prevenir cualquier disfunción en el injerto, siendo un procedimiento tanto diagnóstico como preconizador. Objetivo: Describir los cuidados de enfermería e identificar las complicaciones derivadas de la biopsia renal en los receptores de Trasplante Renal. Material y métodos: Estudio cuantitativo, descriptivo y transversal realizado en la Unidad de Trasplante Renal, Servicio de Nefrología, del 2008 al 2014. La población objeto de estudio son los receptores de Trasplante Renal (TR. La muestra está compuesta por 368 biopsias renales de seguimiento que ingresan para someterse a una biopsia renal. Los criterios de inclusión son ser mayores de 18 años, trasplantados y que han firmado el consentimiento informado. Se recogen datos sociodemográficos, clínico-asistenciales y complicaciones post-biopsia renal. Resultados: Desde 1980 hasta el 2014 se han llevado a cabo 1868 TR, de 2008 a 2014 se estudiaron 368 biopsias de seguimiento. Se monitoriza la Tensión Arterial y la coagulación pre biopsia. Tras el procedimiento, se controla la presencia de sangrado por micción y constantes vitales. Inicialmente el reposo absoluto era de 24 h, a partir de 2014 se reduce a 6 horas, recomendando reposo relativo al alta, las complicaciones fueron mínimas. Conclusiones: Los resultados indican que la biopsia renal es un procedimiento eficaz, con escasas complicaciones. Destacar el papel de enfermería en la detección precoz de complicaciones.

  9. Role of transrectal ultrasonography in evaluating the cause of azoospermia

    Energy Technology Data Exchange (ETDEWEB)

    Yassa, N.A.; Keesara, S. [Univ. of Southern California, Dept. of Radiology, Los Angeles, California (United States)

    2001-08-01

    To assess the role of transrectal ultrasonography in the investigation of azoospermia, a significant cause of infertility. Over a 2-year period, 35 patients with azoospermia underwent an infertility workup, which included transrectal ultrasonography. Sonograms of 10 of the 35 patients were normal; 8 patients had enlarged seminal vesicles containing cysts, 6 had ejaculatory duct dilation, 5 had seminal vesicle calcification, 3 had seminal vesicle atrophy-hypoplasia and 3 patients had midline prostatic cysts. Transrectal sonography is a useful modality to evaluate seminal duct abnormalities, some of which may cause azoospermia. (author)

  10. TRANSRECTAL ULTRASOUND GUIDED PROSTATIC NERVE BLOCKADE FOR PAIN CONTROL DURING TRANSRECTAL PROSTATE BIOPSY

    Institute of Scientific and Technical Information of China (English)

    YANG Liu-ping; DENG Jun-hong; ZHONG Hong; HU Jian-bo; WEI Hong-ai; WANG Liang-sheng

    2005-01-01

    Objective: To assess the effect of transrectal ultrasound guided prostatic nerve blockade on the discomfort associated with systematic biopsy of the prostate. Methods: 73 patients receiving systematic 13 cores biopsy of the prostate were randomized into two groups. Group A(37 cases) received an injection of 5 ml 1% lidocaine into the prostatic neurovascular bundles on each side at the base of the prostate under ultrasound guidance and group B(36 cases) received 5 ml saline injection (0.9% sodium chloride) at the same site. Pain during biopsy was assessed by using a 10-point linear visual analog score (VAS) immediately after the biopsy. Results: The mean pain scores during transrectal prostate biopsy were significantly lower in group A than group B(1.1±0.6 versus 5.9±3.1, t=4.81, P<0.01). During this study no patient in either group had any adverse effect from the injection. Conclusion: Transcrectal ultrasound guided prostatic nerve blockade is a safe and efficacious method for providing satisfactory anesthesia in transrectal prostate biopsy. We recommend its routine administration in all patients during this procedure.

  11. Biopsy needle detection in transrectal ultrasound.

    Science.gov (United States)

    Ayvaci, Alper; Yan, Pingkun; Xu, Sheng; Soatto, Stefano; Kruecker, Jochen

    2011-01-01

    Using the fusion of pre-operative MRI and real time intra-procedural transrectal ultrasound (TRUS) to guide prostate biopsy has been shown as a very promising approach to yield better clinical outcome than the routinely performed TRUS only guided biopsy. In several situations of the MRI/TRUS fusion guided biopsy, it is important to know the exact location of the deployed biopsy needle, which is imaged in the TRUS video. In this paper, we present a method to automatically detect and segment the biopsy needle in TRUS. To achieve this goal, we propose to combine information from multiple resources, including ultrasound probe stability, TRUS video background model, and the prior knowledge of needle orientation and position. The proposed algorithm was tested on TRUS video sequences which have in total more than 25,000 frames. The needle deployments were successfully detected and segmented in the sequences with high accuracy and low false-positive detection rate.

  12. Local staging of prostate cancer with transrectal ultrasound

    DEFF Research Database (Denmark)

    Lorentzen, T; Nerstrom, H; Iversen, P;

    1992-01-01

    A literature review was undertaken to investigate whether transrectal ultrasound can predict the local stage of prostate cancer. Twelve papers were found which correlated ultrasound findings with surgical findings and another paper reported on strategic staging biopsies guided by transrectal...... ultrasound. Eleven of these papers reported on ultrasound findings in patients in whom digital rectal examination had defined localized disease. One paper compared ultrasound findings and digital rectal findings. One paper indicated that transrectal ultrasound, though not suited to patients with clinically...... localized disease defined by digital rectal examination, may be superior as the initial staging tool. We conclude that transrectal ultrasound has too low a specificity to upgrade the diagnostic results of digital rectal examination, but that it may be more useful as the primary staging tool and for guidance...

  13. Life-threatening meningitis resulting from transrectal prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    Zhou-Jun Shen; Shan-Wen Chen; Hua Wang; Xie-Lai Zhou; Ju-Ping Zhao

    2005-01-01

    After antibiotic prophylaxis with metronidazole and levofloxacin, a transrectal sextant biopsy was performed under the guide of transrectal ultrasonography (TRUS) for a 75-year-old suspicious patient with prostate adenocarcinoma.Although antibiotics were also given after this procedure, the patient still developed fever, anxious, agrypnia and headache. Blood cultures remained negative. Lumbar puncture was performed and was consistent with Escherichia coli bacterial meningitis.

  14. Transperineal seed-implantation guided by biplanar transrectal ultrasound

    DEFF Research Database (Denmark)

    Holm, Hans Henrik; Torp-Pedersen, S; Myschetzky, P

    1990-01-01

    A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound.......A new method for precise transperineal placement of therapeutic sources in prostatic cancer is described. The method is a modification of the technique described in 1983 by Holm and coworkers. Insertion of needles is monitored by transverse as well as longitudinal transrectal ultrasound....

  15. Valor de la biopsia de glándulas salivales labiales en el diagnóstico de amiloidosis sistémica.

    OpenAIRE

    Delgado, Wilson

    2013-01-01

    En 78 pacientes con sospecha clínica de amiloidosis secundaria se tomaron igual número de biopsias de glándulas salivales labiales y 26 de encía. Así mismo se analizaron los resultados de 11biopsias renales, 4 de mucosa rectal y 1 de piel. La substancia amiloide fue detectada en todas las biopsias de glándulas salivales (100%),en tanto que en las biopsias de encía se le observó sólo en 4 casos (15%). Los resultados de las biopsias labiales en 42 pacientes control fueron negativos. En 11 pacie...

  16. Dual-Modality Prostate Imaging with PET and Transrectal Ultrasound

    Science.gov (United States)

    2011-09-01

    Page | 16 Shelley A. Caras Steven L. Ferreira David Fraser Jaspal Gill John S. Haugrud Luster D. Howard Ronald H. Huesman Robert T. Kelley William W...or not a lesion is observed using CT or TRUS imaging, which may not be cancerous). We will perform novel functional PET imaging using [11C]choline...determine the tumor “aggressiveness,” but few anatomical features are visible in the PET images. Transrectal ultrasound (TRUS) imaging identifies lesions

  17. Avaliações ultra-sonográfica, macroscópica e histológica da biopsia testicular em ovinos

    OpenAIRE

    Sartori R; Prestes N.C.; Canavessi A.M.O.; Kempinas W.G.; Rosa G.J.M.

    2002-01-01

    Devido ao fato da biopsia testicular poder acarretar hemorragia, inflamação, degeneração, aderência e fibrose, especialmente com as técnicas incisionais ou abertas, este trabalho avaliou a aplicabilidade de uma técnica menos invasiva (biopsia com agulha Tru-Cut) em ovinos na obtenção de material para histologia e acompanhou as lesões testiculares posteriores. Trinta carneiros foram igualmente divididos em três grupos: 1) controle, animais não submetidos à biopsia; 2) submetidos à biopsia + co...

  18. HIPERPLASIA ENDOMETRIAL: ANÁLISIS DE SERIE DE CASOS DIAGNOSTICADOS EN BIOPSIA ENDOMETRIAL

    OpenAIRE

    García Ayala,Ernesto; Cárdenas Mastrascusa,Laura; Sandoval Martínez,Diana; Mayorga Anaya,Henry

    2010-01-01

    Antecedentes: La hiperplasia endometrial es una entidad en la que existe una proliferación de glándulas endometriales de tamaño y forma irregular, con mayor proporción de glándulas sobre el estroma, a consecuencia de una excesiva exposición a los estrógenos. Aproximadamente, en el 15% de legrados/biopsias endometriales de mujeres postmenopausicas con cuadro clínico de hemorragia uterina anormal, se diagnostica esta entidad. Objetivo: Describir la incidencia y hallazgos histopatológicos en leg...

  19. Transrectal Near-Infrared Optical Tomography for Prostate Imaging

    Science.gov (United States)

    2011-03-01

    2009. CA Cancer J Clin. 2009;59:225-249. 2. Hodge KK, McNeal JE, Stamey TA. Ultrasound guided transrectal core biopsies of the palpably abnormal...near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001). [4] Tara Yates, Jeremy C Hebden, Adam Gibson, Nick ...digital rectal examination as screening tests for prostate carcinoma,” J Am Board Fam Pract.; 16(2):95- 101 (2003). 3. Hodge KK, McNeal JE, Stamey TA

  20. BIOPSIA QUIRURGICA CON MARCACION PREOPERATORIA EN LESIONES NO PALPABLES DE LA MAMA: EXPERIENCIA DE 10 AÑOS

    OpenAIRE

    Pardo G,Mario; Sepúlveda P,Sergio; Cuevas G,Claudia; Díaz G,Carolina

    2003-01-01

    El uso sistemático de la mamografía y ultrasonido ha incrementado el diagnóstico de lesiones mamarias no palpables y con ello, la indicación de biopsia. Material y Método: Presentamos nuestra experiencia en 315 biopsias excisionales de lesiones mamarias ocultas con localización preoperatoria. Utilizamos la mamografía en el 83,8% y el ultrasonido en el 10,5% de los casos para posicionar una guía metálica; en el 5,7% se realizó marcación sobre la piel, guiada por ultrasonido. Resultados: Obtuvi...

  1. Optimizing prostate biopsy for repeat transrectal prostate biopsies patients

    Institute of Scientific and Technical Information of China (English)

    Xiaojun Deng; Jianwei Cao; Feng Liu; Weifeng Wang; Jidong Hao; Jiansheng Wan; Hui Liu

    2014-01-01

    Objective:Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer re-mains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods:In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45° angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontal y inwardly inclined 45°. Results:A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8%(8/45), and prostate intraepithelial neoplasm (PIN) was 6.7%(3/45). The pa-tients receiving repeat transrectal prostate biopsies were pathological y diagnosed as lower Gleason grade prostate cancers. Conclusion:The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrectal prostate biopsies patients.

  2. Application of reinforcement learning for segmentation of transrectal ultrasound images

    Directory of Open Access Journals (Sweden)

    Tizhoosh Hamid R

    2008-04-01

    Full Text Available Abstract Background Among different medical image modalities, ultrasound imaging has a very widespread clinical use. But, due to some factors, such as poor image contrast, noise and missing or diffuse boundaries, the ultrasound images are inherently difficult to segment. An important application is estimation of the location and volume of the prostate in transrectal ultrasound (TRUS images. For this purpose, manual segmentation is a tedious and time consuming procedure. Methods We introduce a new method for the segmentation of the prostate in transrectal ultrasound images, using a reinforcement learning scheme. This algorithm is used to find the appropriate local values for sub-images and to extract the prostate. It contains an offline stage, where the reinforcement learning agent uses some images and manually segmented versions of these images to learn from. The reinforcement agent is provided with reward/punishment, determined objectively to explore/exploit the solution space. After this stage, the agent has acquired knowledge stored in the Q-matrix. The agent can then use this knowledge for new input images to extract a coarse version of the prostate. Results We have carried out experiments to segment TRUS images. The results demonstrate the potential of this approach in the field of medical image segmentation. Conclusion By using the proposed method, we can find the appropriate local values and segment the prostate. This approach can be used for segmentation tasks containing one object of interest. To improve this prototype, more investigations are needed.

  3. Biopsia por punción, en los tumores del seno maxilar

    OpenAIRE

    Cleves, Carlos A.; Mendoza, César

    2011-01-01

    Gracias a los adelantos actuales de los exámenes citológicos, en relación con la determinación de los procesos tumorales malignos, contamos en nuestra especialidad con un medio más para el diagnóstico de los tumores de los senos maxilares.Al examen clínico y radiológico podemos agregar hoy día el examen citológico, el cual tiene la enorme ventaja de ser de fácil ejecución, sin los inconvenientes que por el traumatismo se presenten cuando se practica la biopsia del tumor haciendo una trepanaci...

  4. Transrectal ultrasonography of anorectal disease: advantages and disadvantages

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Ju [Dept. of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul (Korea, Republic of)

    2015-01-15

    Transrectal ultrasonography (TRUS) has been widely accepted as a popular imaging modality for Epub ahead of print evaluating the lower rectum, anal sphincters, and pelvic floor in patients with various anorectal diseases. It provides excellent visualization of the layers of the rectal wall and of the anatomy of the anal canal. TRUS is an accurate tool for the staging of primary rectal cancer, especially for early stages. Although magnetic resonance imaging is a modality complementary to TRUS with advantages for evaluating the mesorectum, external sphincter, and deep pelvic inflammation, three-dimensional ultrasonography improves the detection and characterization of perianal fistulas and therefore plays a crucial role in optimal treatment planning. The operator should be familiar with the anatomy of the rectum and pelvic structures relevant to the preoperative evaluation of rectal cancer and other anal canal diseases, and should have technical proficiency in the use of TRUS combined with an awareness of its limitations compared to magnetic resonance imaging.

  5. [Calcifications of the prostate: a transrectal echographic study].

    Science.gov (United States)

    Bock, E; Calugi, V; Stolfi, V; Rossi, P; D'Ascenzo, R; Solivetti, F M

    1989-05-01

    Prostatic lithiasis is a well know phenomenon. It has little clinical significance and is not easily shown by conventional radiography, which has poor sensitivity and specificity. The authors have studied 612 patients with both suprapubic and transrectal US in order to 1) assess US sensitivity and specificity and 2) report the frequency, spatial distribution, number and features of prostatic calcifications with special emphasis on differential diagnosis between prostatic neoplasms and chronic prostatitis. The authors have also studied the relationship between morphology and symptoms and the results agree with those reported in the scanty literature. The authors conclude that the parameters studied are directly related to age, except for a younger group with clear evidence of genital inflammation. The authors emphasize the impossibility to correlate morphology of prostatic calcifications with pathologic conditions: there are no specific symptoms clearly connected with calcification even though the inflammation is often associated with calcifications.

  6. Ultrasound-guided transrectal extended prostate biopsy: a prospective study

    Institute of Scientific and Technical Information of China (English)

    Mohammed Ahmed Al-Ghazo; Ibrahim Fathi Ghalayini; Ismail Ibrahim Matalka

    2005-01-01

    Aim: To evaluate the diagnostic value of the 10 systematic transrectal ultrasound-guided (TRUS) prostate biopsy compared with the sextant biopsy technique for patients with suspected prostate cancer. Methods: One hundred and fifty-two patients with suspected prostate cancer were included in the study. Patients were entered in the study because they presented with high levels of prostate specific antigen (PSA) (over 4 ng/mL) and/or had undergone an abnormal digital rectal examination (DRE). In addition to sextant prostate biopsy cores, four more biopsies were obtained from the lateral peripheral zone with additional cores from each suspicious area revealed by transrectal ultrasound. Sextant, lateral peripheral zone and suspicious area biopsy cores were submitted separately to the pathological department. Results: Cancer detection rates were 27.6% (42/152) and 19.7% (30/152) for the 10-core and sextant core biopsy protocols, respectively. Adding the lateral peripheral zone (PZ) to the sextant prostate biopsy showed a 28.6% (12/42) increase in the cancer detection rate in patients with positive prostate cancer (P < 0.01).The cancer detection rate in patients who presented with elevated PSA was 29.3% (34/116). When serum PSA was 4-10 ng/mL TRUS-guided biopsy detected cancer in 20.6%, while the detection rate was 32.4% and 47.0% when serum PSA was 10-20 ng/mL and above 20 ng/mL, respectively. Conclusion: The 10 systematic TRUS-guided prostate biopsy improves the detection rate of prostate cancer by 28.6% when compared with the sextant biopsy technique alone, without increase in the morbidity. We therefore recommend the 10-core biopsy protocol to be the preferred method for early detection of prostate cancer.

  7. The diagnostic value of transrectal ultrasonographic features in prostate cancer

    Institute of Scientific and Technical Information of China (English)

    Xiaoli Zou; Guang Yang; Hui Wang

    2012-01-01

    Objective: The aim of the study was to detect the valuable ultrasonographic features in diagnosing prostate cancer.Methods: The patients who underwent transrectal ultrasound in the period from May 2005 to October 2009 at the 1st Affiliated Hospital of Dalian Medical University, China, were included, with needle biopsy diagnosis for patients with the prostate cancer and prostatic hyperplasia.Seventy-four cases of prostate cancer were diagnosed as adenocarcinoma, compared with 51 cases diagnosed as prostatic hyperplasia.Retrospective analysis of patients with transrectal ultrasound were done, comparing the difference between the two groups in the echo level (hypoechogenic), outlines (ill-defined margin), posterior acoustic attenuation, periphery halo, microcalcification incidence, the blood supply level, peak systolic velocity (Vs) and resistance index (RI).Results: The ratios of hypoechogenic lesions in the prostate cancer group and prostatic hyperplasia group were 56.76% and 35.90%, respectively (P 0.05).Vs of the two groups were (44.00 ± 15.30) cm/s and (17.32 ± 4.65) cm/s, respectively (P < 0.05).RI of the two groups were 0.76 ± 0.10, and 0.51 ± 0.03 respectively (P < 0.05).The significant correlation was designated in the blood supply level between the prostate cancer group and prostatic hyperplasia group (r = -0.388, P < 0.01).Higher revascularization grade was seen in the prostate cancer group compared to benign prostatic hyperplasia group.Conclusion: (1) The significant roles for diagnosing prostate cancer are hypoechogenic, irregular outlines, spiculation, microcalcification, high revascularization grade, posterior acoustic attenuation, high Vs and high RI.(2) It could not help in diagnosing prostate cancer with ultrasonographic periphery halo or not.

  8. Correlación anatomopatológica entre la biopsia preoperatoria y la pieza quirúrgica de quistes dentigeros y queratoquistes odontogenicos

    OpenAIRE

    Mordcovich Maldonado, Gonzalo

    2014-01-01

    En este estudio se analizó la correlación entre las biopsias preoperatoria y posoperatoria de 15 pacientestratados con quistes dentígeros (QD) y 15 pacientes tratados con queratoquistes (QQ). De esta manera se comparó cual de las dos patologías es más propensa a presentar transformaciones histopatológicas, su relación con el sexo, la edad, el mayor número de recidivas y la localización anatómica más frecuente Objetivo: se realizó el estudio de las biopsias preoperatorias (biopsia por imcisión...

  9. Biopsia Hepática Percutânea na Criança - Experiência de 10 anos

    OpenAIRE

    Lopes, Ana Isabel; Costa, Adília

    2014-01-01

    A biopsia hepática percutânea (BHP) na criança é um meio de diagnóstico essencial na investigação da doença hepática, mas que envolve risco de morbilidade e mortalidade não negligenciáveis.Novas modalidades inerentes ao procedimento têm vindo a ser propostas, designadamente quanto à própria técnica e quanto ao regime de vigilância pós-biopsia. Apresenta-se a experiência pessoal de BHP no período de 10 anos (1994 - 2003) referente a casuística não associada a transplante hepático (80 biópsias ...

  10. Histología de la biopsia hepática, enfoque para el clínico

    Directory of Open Access Journals (Sweden)

    Fernando Brenes-Pino

    2008-11-01

    Full Text Available La biopsia hepática es necesaria para la evaluación de la hepatitis crónica. Su utilidad reside en la valoración del grado de inflamación y fibrosis del paciente con hepatitis crónica. La utilización de un sistema semicuantitativo para la clasificación de las biopsias de hepatitis crónicas es necesaria con el fin de tener parámetros menos subjetivos, y para comparar la evolución ante una potencial terapia. Se establece una puntuación semicuantitativa que determina la graduación y el estadiaje. Se considera importante tener como mínimo para la valoración de una biopsia hepática, la presencia al menos de 3-5 espacios porta y realizar tinciones de rutina como hematoxilina eosina, tricromico, reticulita y orceina. Se considera básico para la definición de los tratamientos la actividad inflamatoria y el estadio de la fibrosis, apoyando a la parte clínica, bioquímica y de biología molecular del virus de hepatitis B.

  11. Biopsia en enfermedad intersticial pulmonar Lung biopsy for the diagnosis of interstitial lung disease

    Directory of Open Access Journals (Sweden)

    Silvia Quadrelli

    2007-12-01

    Full Text Available El objetivo del presente estudio fue determinar el rédito diagnóstico y los factores asociados a mayor morbimortalidad en la biopsia quirúrgica de pulmón en pacientes con enfermedad intersticial difusa. Se analizaron en forma retrospectiva los registros clínicos de 71 pacientes. Se registraron complicaciones en 16 pacientes (22.5%. La mortalidad operatoria fue 11.2%. Los pacientes en quienes la biopsia se realizó por videotoracoscopia (n = 52 y por toracotomía (n = 17 tuvieron la misma duración de estadía en terapia intensiva y de estadía hospitalaria. La tasa de complicaciones (22.2% vs. 21.0%, p = 1.0000 y la mortalidad (9.2 vs. 15.7%, p = 0.2738 no fueron diferentes. Ocho pacientes murieron dentro de los 30 días. La prevalencia de inmunosupresión (4/8 vs. 9/63, p = 0.0325 fue significativamente superior en el grupo de pacientes fallecidos. Estos pacientes tuvieron valores preoperatorios más elevados de urea (50 ± 20.1 mg/dl vs. 31.2 ± 10.3 mg/ dl, p = 0.0013 y menores valores de saturación de O2: 82.7 ± 14.8% vs. 92.8 ± 3.4%, p = 0.0009. En los 11 pacientes con iniciación aguda la mortalidad fue significativamente más elevada (36.3% vs. 7.1%, p = 0.0223. La biopsia aportó un diagnóstico específico en 100% de los pacientes y cambió la estrategia terapéutica en 66.7%. En conclusión, la biopsia de pulmón por vía toracoscópica es un procedimiento útil y seguro en los pacientes con enfermedad intersticial difusa del pulmón. Sin embargo, en el grupo de pacientes inmunocomprometidos, con cuadros de presentación aguda y con insuficiencia respiratoria preoperatoria, la mortalidad es elevada y deben balancearse muy críticamente los riesgos contra los beneficios en ese grupo de enfermos.The objective of this study was to determine the morbidity, mortality and diagnostic yield of video assisted thoracoscopy (VATS and thoracotomy lung biopsy in interstitial lung disease (ILD. Clinical records of 71 patients were

  12. Transrectal ultrasound of the prostate bed after collagen injection

    Energy Technology Data Exchange (ETDEWEB)

    Salomon, C.G.; Dudiak, C.M.; Pyle, J.M.; Wheeler, J.S.; Waters, W.B.; Flanigan, R.C. [Loyola Univ. Medical Center, Maywood, IL (United States)

    1996-03-01

    Transurethral injection of collagen (TCI) may be used to treat urinary incontinence following radical prostatectomy for prostate cancer. The transrectal ultrasound (TRUS) findings after TCI are described in this report. TRUS exams of four postprostatectomy patients who had undergone TCI were reviewed. Findings were correlated with pathologic specimens obtained at TRUS-guided core biopsy. These histologic specimens were compared with others from postprostatectomy patients who had not undergone TCI. Well defined bladder apex masses of uniform echogenicity, hypoechoic to adjacent fat and muscle, were identified sonographically in all TCI patients. Masses from which positive biopsies were obtained were similar in appearance to those with no malignant. Hypocellular fibrous tissue and foci of acellular loose connective tissue were identified in the biopsies of those patients who had undergone TCI No acellular areas were identified in specimens from patients who had not had TCI. Sequelae of to should be included in the differential diagnosis of perianastomotic masses in postprostatectomy patients. However, the need for biopsy is not obviated as residual or recurrent prostate carcinoma may coexist. 14 refs., 4 figs.

  13. Framework for 3D TransRectal Ultrasound

    CERN Document Server

    Mozer, Pierre; Chevreau, G; Daanen, Vincent; Moreau-Gaudry, Alexandre; Troccaz, Jocelyne

    2008-01-01

    Prostate biopsies are mainly performed under 2D TransRectal UltraSound (TRUS) control by sampling the prostate according to a predefined pattern. In case of first biopsies, this pattern follows a random systematic plan. Sometimes, repeat biopsies can be needed to target regions unsampled by previous biopsies or resample critical regions (for example in case of cancer expectant management or previous prostatic intraepithelial neoplasia findings). From a clinical point of view, it could be useful to control the 3D spatial distribution of theses biopsies inside the prostate. Modern 3D-TRUS probes allow acquiring high-quality volumes of the prostate in few seconds. We developed a framework to track the prostate in 3D TRUS images. It means that if one acquires a reference volume at the beginning of the session and another during each biopsy, it is possible to determine the relationship between the prostate in the reference and the others volumes by aligning images. We used this tool to evaluate the ability of a si...

  14. Utilidad de la biopsia transbronquial en el diagnostico de enfermedades pulmonares en pacientes VIH/SIDA

    Directory of Open Access Journals (Sweden)

    Carmen Elena Fuenmayor

    2014-04-01

    Full Text Available La biopsia transbronquial es una herramienta útil en el diagnóstico de un grupo heterogéneo de enfermedades pulmonares. El objetivo del presente estudio fue determinar la etiología de los procesos pulmonares más frecuentes en el grupo de pacientes VIH/SIDA controlados en el Instituto Autónomo Hospital Universitario de los Andes durante el periodo febrero a septiembre del 2009. Se realizó un estudio observacional, analítico y descriptivo con enfoque epidemiológico, clínico y anatomopatológico en un grupo de 39 pacientes portadores de virus de Inmunodeficiencia Humana. De estos solamente 36 cumplieron los criterios de inclusión para esta investigación. Se hicieron análisis sanguíneo, perfil inmunológico, estudios imagenológicos, lavado bronco-alveolar, cepillado bronquial y biopsia transbronquial. Los cortes histológicos mostraron respuesta inflamatoria en diferentes fases de evolución, daño alveolar difuso y edema intraalveolar. Se realizó el diagnóstico de un grupo de enfermedades oportunistas tales como: neumocistosis, Histoplasmosis, Candidiasis y lesiones probablemente debidas a virus Herpes y Citomegalovirus. Se destaca la participación de más de un germen. Además hubo vasculitis, trombos, áreas de infarto, fibrosis intersticial y hallazgos sugestivos de Hipertensión Pulmonar. Uno de los pacientes presento neoplasia maligna epitelial indiferenciada. El empleo de esta técnica permitió evaluar la presencia de infecciones oportunistas y neoplasias infrecuentes, así como los hallazgos sugestivos de Hipertensión pulmonar. Se avala su utilización ante la necesidad de realizar un diagnóstico etiológico de certeza y establecer así la terapéutica adecuada. Utility transbronchial biopsy in the diagnosis ofpulmonary disease in patients HIV/AIDS Abstract Transbronchial biopsy is a useful tool in the diagnosis of a heterogeneous group of lung diseases. The aim of this study was to determine the etiology of pulmonary

  15. Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia

    Institute of Scientific and Technical Information of China (English)

    Sandro La Vignera; Aldo E. Calogero; Alessandro Arancio; Roberto Castighone; Gaetano De Grande; Enzo Vicari

    2008-01-01

    Aim: To identify and define prostate and seminal vesicle abnormalities in patients with chronic male accessory gland infection (MAGI) who failed to respond to antibacterial treatment. Methods: We selected 67 consecutive patients with MAGI and persistently elevated bacteriospermia (≥ 106 colony forming units [CFU]/mL) after three antibiotic courses. Fourteen infertile patients with initial chronic microbial (≥ 106 CFU/mL) MAGI who responded to antibac- terial treatment (< 103 CFU/mL) served as a control group. All patients and controls underwent transrectal ultrasonog- raphy (TRUS) scans and semen analysis. Patients with low seminal plasma volume (< 1.5 mL) underwent both pre- ejaculatory and post-ejaculatory TRUS examination. Results: TRUS revealed multiple abnormalities indicative of: (I) bilaterally extended prostato-vesiculitis (group A: 52 cases, 77.6%) (nine of these patients also had micro-emphyse- matous prostate abscess); and (ii) prostato-vesiculitis with unilateral or bilateral sub-obstruction of the ejaculatory ducts (group B: 15 cases, 22.4%). Mean sperm concentration, total sperm number, ejaculate volume and pH value were significantly higher in group A than in group B. In addition, sperm forward motility and the percentage of normal forms were significantly worse than in controls, whereas leukocyte concentration was significantly higher in group A. Group B patients had all sperm parameters, but their pH values, significantly different from those of controls. Confusion: Although antibiotic therapy is considered suitable when microbial MAGI is suspected, it is impossible to account for a poor response to antibiotics merely on the basis of conventional criteria (clinical history, physical and ejaculate signs). Thus, TRUS may be helpful in the follow-up of these patients.

  16. Diagnóstico inicial de Linfoma de Hodgkin en biopsias de médula ósea

    OpenAIRE

    Kitagawa, R. B.; Martín, C. A.

    2016-01-01

    El Linfoma de Hodgkin (LH) es una neoplasia maligna de células linfoides B, habitualmente originada a nivel de los ganglios linfáticos. Durante la evolución de la enfermedad puede producirse el compromiso medular, que varía del 1 al 10% según el subtipo histopatológico, siendo éste muy raro como sitio inicial de presentación. Presentamos seis casos de LH diagnosticados inicialmente en biopsias de médula ósea.

  17. Feasibility of a pneumatically actuated MR-compatible robot for transrectal prostate biopsy guidance

    NARCIS (Netherlands)

    Yakar, D.; Schouten, M.G.; Bosboom, D.G.H.; Barentsz, J.O.; Scheenen, T.W.J.; Futterer, J.J.

    2011-01-01

    PURPOSE: To assess the feasibility of using a remote-controlled, pneumatically actuated magnetic resonance (MR)-compatible robotic device to aid transrectal biopsy of the prostate performed with real-time 3-T MR imaging guidance. MATERIALS AND METHODS: This prospective study was approved by the ethi

  18. Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer

    Science.gov (United States)

    2012-10-01

    transrectal ultrasound Imaging to monitor the photocoagulation front during interstitial photothermal therapy of primary focal prostate,” SPIE...collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching data sources, gathering and...maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other

  19. Midline fascial plication under continuous digital transrectal control: which factors determine anatomic outcome?

    NARCIS (Netherlands)

    Milani, A.L.; Withagen, M.I.J.; Schweitzer, K.J.; Janszen, E.W.; Vierhout, M.E.

    2010-01-01

    INTRODUCTION AND HYPOTHESIS: The aim of the study was to report anatomic and functional outcome of midline fascial plication under continuous digital transrectal control and to identify predictors of anatomic failure. METHODS: Prospective observational cohort. Anatomic success defined as POP-Q stage

  20. Transrectal ultrasound of the prostatic urethra related to urodynamically assessed urethral resistance. A pilot study

    NARCIS (Netherlands)

    R. van Mastrigt (Ron); R. Kranse (Ries); H. Jansen

    1994-01-01

    textabstractIn this pilot study on 17 men who underwent urodynamic investigation for various dysuric complaints, real-time transrectal ultrasonography (TRUS) was performed. From the images anatomical parameters were identified that correlated with obstructive urodynamic findings and urethral resista

  1. Transrectal Ultrasound-guided Systematic 13-Core Prostate Biopsy to Diagnose Prostate Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Liuping Yang; Junhong Deng; Hong Zhong; Jianbo Hu; Hongai Wei; Liangsheng Wang

    2005-01-01

    OBJECTIVE To evaluate the clinical value of transrectal ultrasound guided systematic 13-core prostate biopsy.METHODS A total of 213 patients referred for abnormal digital rectal examination and/or with a prostate specific antigen of 4 ng/ml or greater underwent transrectal ultrasound guided systematic 13-core prostate biopsy. This procedure was conducted in addition to the standard sextant biopsies in which cores were taken from the far lateral and middle regions of the gland as described by Eskew. Fathological findings of the additional regions were compared with those of the sextant regions.RESULTS Of the 213 patients 31% had cancer on biopsy (66/213). Of the 66 patients with prostate cancer 14 (21%) had carcinoma only in the additional regions, which would have remained undetected had the sextant biopsy technique been used alone (P<0.05). No severe complications occurred among the patients who underwent transrectal ultrasound guided systematic 13-core prostate biopsy.CONCLUSION Our data demonstrated that transrectal ultrasound guided systematic 13-core prostate biopsy can significantly increase the cancer detection rate. It is safe and efficacious, and should be recommended for use clinically.

  2. Transrectal ultrasonography and magnetic resonance imaging in the staging of rectal cancer. Effect of experience

    DEFF Research Database (Denmark)

    Rafaelsen, Søren R; Sørensen, Torben; Jakobsen, Anders

    2008-01-01

    OBJECTIVE: To evaluate the effect of experience on preoperative staging of rectal cancer using magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS). MATERIAL AND METHODS: From January 2002 to May 2006, 134 consecutive patients with biopsy-proven rectal cancer were examined with a 1....... In addition to this supervision, the person responsible for staging should be trained through a defined training programme....

  3. Comparison of transrectal photoacoustic, Doppler, and magnetic resonance imaging for prostate cancer detection

    Science.gov (United States)

    Ishihara, Miya; Horiguchi, Akio; Shinmoto, Hiroshi; Tsuda, Hitoshi; Irisawa, Kaku; Wada, Takatsugu; Asano, Tomohiko

    2016-03-01

    Transrectal ultrasonography (TRUS) is the most popular imaging modality for diagnosing and treating prostate cancer. TRUS-guided prostate biopsy is mandatory for the histological diagnosis of patients with elevated serum prostatespecific antigen (PSA), but its diagnostic accuracy is not satisfactory due to TRUS's low resolution. As a result, a considerable number of patients are required to undergo an unnecessary repeated biopsy. Photoacoustic imaging (PAI) can be used to provide microvascular network imaging using hemoglobin as an intrinsic, optical absorption molecule. We developed an original TRUS-type PAI probe consisting of a micro-convex array transducer with an optical illumination system to provide superimposed PAI and ultrasound images. TRUS-type PAI has the advantage of having much higher resolution and greater contrast than does Doppler TRUS. The purpose of this study was to demonstrate the clinical feasibility of the transrectal PAI system. We performed a clinical trial to compare the image of the cancerous area obtained by transrectal PAI with that obtained by TRUS Doppler during prostate biopsy. The obtained prostate biopsy cores were stained with anti-CD34 antibodies to provide a microvascular distribution map. We also confirmed its consistency with PAI and pre-biopsy MRI findings. Our study demonstrated that transrectal identification of tumor angiogenesis under superimposed photoacoustic and ultrasound images was easier than that under TRUS alone. We recognized a consistent relationship between PAI and MRI findings in most cases. However, there were no correspondences in some cases.

  4. La biopsia oral en el contexto del precáncer y del cáncer oral Oral biopsy in the context of oral cancer and precancer

    Directory of Open Access Journals (Sweden)

    J.M. Seoane

    2008-02-01

    Full Text Available Es este artículo se revisa el papel de la biopsia oral en el diagnóstico de lesiones precancerosas y en el diagnóstico precoz del cáncer oral. Se discuten diferentes técnicas, procedimientos, materiales, indicaciones y aspectos quirúrgicos. Se propone efectuar biopsias incisionales en lesiones malignas y sospechosas de malignidad, en tanto se preconizan biopsias escisionales, cuando el tamaño lo permita, en lesiones precancerosas.This article reviews the paper of oral biopsy on the precancerous lesions diagnosis and on the oral cancer early diagnosis. Different techniques, procedures, materials, indications and other surgical aspects are debated. It proposes to do incisional biopsies on malignant lesions and on malignant suspicious lesions, while doing excisional biopsies on precancerous lesions when the size allows it.

  5. AVALIAÇÃO QUANTITATIVA E QUALITATIVA, DA TÉCNICA DE BIOPSIA RENAL “DE JANELA” EM CÃES

    Directory of Open Access Journals (Sweden)

    Veridiana Maria Brianezi Dignani de Moura

    2006-10-01

    Full Text Available Foram biopsiados os rins de 86 cães pela técnica “de janela”, utilizando agulhas Vim Tru-Cut, com o objetivo de avaliar o número de glomérulos presentes nas amostras, determinar a qualidade diagnóstica delas, bem como estabelecer o melhor rim a ser biopsiado nos casos de nefropatia canina em que a biopsia é indicada como meio de diagnóstico. A média de glomérulos presentes nas biopsias dos rins direito e esquerdo foi 17,53 e 15,93 glomérulos por amostra, respectivamente, o que significa que não houve diferença estatística significativa. No entanto, as biopsias dos rins esquerdos apresentaram maior número de amostras sem glomérulos, dado que indica que elas são impróprias para o diagnóstico. Diante desses resultados conclui-se que o rim direito é o mais apropriado para a realização dessa técnica, uma vez que ele apresenta menor possibilidade de ocorrência de amostras sem glomérulos. PALAVRAS-CHAVE: Cão, biopsia renal “de janela”, glomérulo.

  6. Biopsia cerebral a mano alzada guiada por tomografía Cerebral biopsy by a handfree procedure

    Directory of Open Access Journals (Sweden)

    Juan Carlos Arango

    1998-03-01

    Full Text Available Se presenta la experiencia del Servicio de Neurocirugía del Hospital Universitario San Vicente de Paúl con un procedimiento alternativo para realizar una biopsia cerebral, el cual se lleva a cabo a mano alzada y guiado por tomografía sin utilizar un marco estereotáxico. Se resalta su utilidad en los casos de lesiones supratentoriales y con tamaño mayor de 3 centímetros, en centros donde no se disponga de los métodos estereotáxicos tradicionales. We report the experience at the Neurosurgery Service, Saint Vincent's University Hospital (Medellín, Colombia with a hand free procedure for performing brain biopsies, without stereotactical frames. It is considered useful in supratentorial lesions larger than 3 cm, in places lacking stereotactical technology.

  7. Repeat biopsy in patients with initial diagnosis of PIN; La biopsia ripetuta nei pazienti con diagnosi iniziale di PIN

    Energy Technology Data Exchange (ETDEWEB)

    De Matteis, Massimo [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Albertoni; Poggi, Cristina; De Martino, Antonietta; Pavlica, Pietro [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia Palagi, Dipartimento area radiologica; Corti, Barbara [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Anatomia ed istologia patologica, Dipartimento oncologico ed ematologico; Barozzi, Libero [Azienda Ospedaliera Policlinico S. Orsola-Malpighi, Bologna (Italy). UO Radiologia d' urgenza, Dipartimento emergenze ed accettazione

    2005-09-15

    indirizzare i pazienti alla biopsia ripetuta. Materiale e metodi. Abbiamo valutato i risultati di 72 biopsie ripetute in pazienti con una diagnosi di PIN ad una prima agobiopsia prostatica ecoguidata. A tutti e stato effettuato un numero minimo di 6 prelievi. Tutti avevano un PSA>4 ng/ml. Risultati. Sono stati rilevati alla biopsia ripetuta 15 adenocarcinomi su 50 pazienti (30%) con diagnosi iniziale di PIN a basso grado e 10 carcinomi su 22 (45,4%) con PIN ad alto grado. Sono stati diagnosticati 7 carcinomi in 18 pazienti (39%) nei quali il PSA era diminuito durante l'intervallo di osservazione, in 16 su 46 (35%) nei quali il PSA in aumento e 2 su 8 casi (25%) con PSA stabile. Conclusioni. I risultati sembrano confermare che il PIN puo essere considerato un precursore dell'adenocarcinoma prostatico o un'alterazione istologica frequentemente associata ad esso. I pazienti con diagnosi iniziale di PIN a basso grado e soprattutto quelli con PIN ad alto grado dovrebbero sistematicamente essere sottoposti a biopsia ripetuta a breve distanza per l'elevata frequenza di diagnosi finale di carcinoma. Non esistono ancora indicazioni condivise sull'intervallo temporale tra le due biopsie. Le variazioni del PSA che si possono riscontrare durante il periodo di osservazione non rappresentano un parametro statisticamente significativo per proporre o meno al paziente la ripetizione della biopsia prostatica.

  8. Análisis del valor de la biopsia del ganglio centinela en el melanoma cutáneo

    Directory of Open Access Journals (Sweden)

    C. Carrasco-López

    2015-09-01

    Full Text Available El melanoma cutáneo es una neoplasia cuya incidencia va en aumento en nuestro medio. Presentamos un estudio sobre 1023 casos de esta patología recogidos a lo largo de 20 años, distribuidos en 2 grupos: grupo A tratados antes del 2000, y grupo B tratados después del 2000. Comparamos la supervivencia de ambos grupos en base al cambio de tratamiento por la introducción del estudio del ganglio centinela a partir del año 2000. No observamos diferencias significativas entre los 2 grupos en la supervivencia de los pacientes con melanoma a pesar de realizar tratamientos más conservadores. Por tanto, gracias a la biopsia de ganglio centinela, se pueden evitar un 75% de linfadenectomías electivas realizadas en este tipo de patología sin modificar los índices de supervivencia.

  9. The results of transrectal prostate biopsy in patients with low levels of prostate specific antigen

    Directory of Open Access Journals (Sweden)

    Ahmet Ali Sancaktutar

    2012-06-01

    Full Text Available Objectives: The aim of this study is to evaluate the resultsof prostate biopsy of patients who had the prostatespecificantigen (PSA levels below 4 ng/ml.Material and methods: The medical records of 63 patientswho underwent transrectal prostate biopsy, betweenJanuary 2005 and December 2011, due to suspicionof prostate cancer with the PSA levels under 4 ng/mlwere retrospectively reviewed.Results: Transrectal Prostate biopsy was performed to63 patients. Prostate cancer was detected in 12 (19%patients. The mean value of PSA was 2.5 ng/ml. TheGleason score of Prostate cancer patients was 6,8 (5-7and the number of positive cores were 3.Conclusions: The rate of prostate cancer was found as19% in patients with levels of PSA under 4 ng/ml and thisratio is compatible with the results of previous reports.

  10. Mapping of transrectal ultrasonographic prostate biopsies: quality control and learning curve assessment by image processing

    CERN Document Server

    Mozer, Pierre; Chevreau, Gregoire; Moreau-Gaudry, Alexandre; Bart, Stephane; Renard-Penna, Raphaele; Comperat, Eva; Conort, Pierre; Bitker, Marc-Olivier; Chartier-Kastler, Emmanuel; Richard, Francois; Troccaz, Jocelyne

    2009-01-01

    Objective: Mapping of transrectal ultrasonographic (TRUS) prostate biopsies is of fundamental importance for either diagnostic purposes or the management and treatment of prostate cancer, but the localization of the cores seems inaccurate. Our objective was to evaluate the capacities of an operator to plan transrectal prostate biopsies under 2-dimensional TRUS guidance using a registration algorithm to represent the localization of biopsies in a reference 3-dimensional ultrasonographic volume. Methods: Thirty-two patients underwent a series of 12 prostate biopsies under local anesthesia performed by 1 operator using a TRUS probe combined with specific third-party software to verify that the biopsies were indeed conducted within the planned targets. RESULTS: The operator reached 71% of the planned targets with substantial variability that depended on their localization (100% success rate for targets in the middle and right parasagittal parts versus 53% for targets in the left lateral base). Feedback from this ...

  11. Antibiotic prophylaxis for transrectal ultrasound biopsy of the prostate in Ireland.

    LENUS (Irish Health Repository)

    Smyth, L G

    2012-03-01

    Prostate cancer is the most common solid cancer affecting men in Ireland. Transrectal ultrasound (TRUS) biopsies of the prostate are routinely performed to diagnose prostate cancer. They are, in general, a safe procedure but are associated with a significant risk of infective complications ranging from fever, urinary tract infection to severe urosepsis. At present, there are no recommended national guidelines on the use of antibiotic prophylaxis to minimise the risk of infective complications post-TRUS biopsy.

  12. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    OpenAIRE

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU) treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since...

  13. Fully Automated Prostate Magnetic Resonance Imaging and Transrectal Ultrasound Fusion via a Probabilistic Registration Metric

    OpenAIRE

    Sparks, Rachel; Bloch, B. Nicolas; Feleppa, Ernest; Barratt, Dean; Madabhushi, Anant

    2013-01-01

    In this work, we present a novel, automated, registration method to fuse magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) images of the prostate. Our methodology consists of: (1) delineating the prostate on MRI, (2) building a probabilistic model of prostate location on TRUS, and (3) aligning the MRI prostate segmentation to the TRUS probabilistic model. TRUS-guided needle biopsy is the current gold standard for prostate cancer (CaP) diagnosis. Up to 40% of CaP lesions appea...

  14. Midline Cysts in the Prostate: Incidence in Healthy Men on Transrectal Ultrasonography (TRUS)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Eun Kyoung; Lee, Yong Seok [Dongguk University Il-san Hospital, Goyang (Korea, Republic of); Kim, Sun Ho [National Cancer Center, Goyang (Korea, Republic of)

    2011-12-15

    To describe the incidence of prostatic midline cysts in healthy men on transrectal ultrasonography. From 2005 to 2009, 1,175 transrectal ultrasonography examinations were performed on 1,086 men (22-85 years) in a health promotion center. Incidence and size of midline cysts in men without any symptoms in the genitourinary tract were investigated according to age, prostate volume, and other ultrasonography findings. The incidence of midline cysts in healthy men was 28% (280/999). The mean diameter of midline cysts was 7.2 mm (1-30 mm). The incidence was the highest (32/102; 31.4%) and the size was the smallest (6.2 mm in mean) in men older than 60 years. The incidence of midline cysts in prostates larger than 20 ml was 33.2% (157/473) and in prostates smaller than or equal to 20 ml was 23.4% (123/526) (p < 0.05). Abnormal ultrasonography findings other than midline cysts were found in 196 men, and the incidence of midline cysts was high with seminal vesicle abnormalities (5/11: 45.5%). The incidence of prostatic midline cysts in healthy men on transrectal ultrasonography is higher than the result of previous studies. The incidence is higher in an enlarged prostate than in a prostate of normal size

  15. Analysis of Preoperative Detection for Apex Prostate Cancer by Transrectal Biopsy

    Directory of Open Access Journals (Sweden)

    Tomokazu Sazuka

    2013-01-01

    Full Text Available Background. The aim of this study was to determine concordance rates for prostatectomy specimens and transrectal needle biopsy samples in various areas of the prostate in order to assess diagnostic accuracy of the transrectal biopsy approach, especially for presurgical detection of cancer in the prostatic apex. Materials and Methods. From 2006 to 2011, 158 patients whose radical prostatectomy specimens had been evaluated were retrospectively enrolled in this study. Concordance rates for histopathology results of prostatectomy specimens and needle biopsy samples were evaluated in 8 prostatic sections (apex, middle, base, and transitional zones bilaterally from 73 patients diagnosed at this institution, besides factors for detecting apex cancer in total 118 true positive and false negative apex cancers. Results. Prostate cancer was found most frequently (85% in the apex of all patients. Of 584 histopathology sections, 153 (49% from all areas were false negatives, as were 45% of apex biopsy samples. No readily available preoperative factors for detecting apex cancer were identified. Conclusions. In Japanese patients, the most frequent location of prostate cancer is in the apex. There is a high false negative rate for transrectal biopsy samples. To improve the detection rate, transperitoneal biopsy or more accurate imaging technology is needed.

  16. Effect on hemostasis of an absorbable hemostatic gelatin sponge after transrectal prostate needle biopsy

    Directory of Open Access Journals (Sweden)

    Kohei Kobatake

    2015-04-01

    Full Text Available Objectives To examine the usefulness of an absorbable hemostatic gelatin sponge for hemostasis after transrectal prostate needle biopsy. Subjects and Methods The subjects comprised 278 participants who underwent transrectal prostate needle biopsy. They were randomly allocated to the gelatin sponge insertion group (group A: 148 participants and to the non-insertion group (group B: 130 participants. In group A, the gelatin sponge was inserted into the rectum immediately after biopsy. A biopsy-induced hemorrhage was defined as a case in which a subject complained of bleeding from the rectum, and excretion of blood clots was confirmed. A blood test was performed before and after biopsy, and a questionnaire survey was given after the biopsy. Results Significantly fewer participants in group A required hemostasis after biopsy compared to group B (3 (2.0% vs. 11 (8.5%, P=0.029. The results of the blood tests and the responses from the questionnaire did not differ significantly between the two groups. In multivariate analysis, only “insertion of a gelatin sponge into the rectum” emerged as a significant predictor of hemostasis. Conclusion Insertion of a gelatin sponge into the rectum after transrectal prostate needle biopsy significantly increases hemostasis without increasing patient symptoms, such as pain and a sense of discomfort.

  17. Clinically low-risk prostate cancer: evaluation with transrectal doppler ultrasound and functional magnetic resonance imaging

    Directory of Open Access Journals (Sweden)

    Maria Inês Novis

    2011-01-01

    Full Text Available OBJECTIVES: To evaluate transrectal ultrasound, amplitude Doppler ultrasound, conventional T2-weighted magnetic resonance imaging, spectroscopy and dynamic contrast-enhanced magnetic resonance imaging in localizing and locally staging low-risk prostate cancer. INTRODUCTION: Prostate cancer has been diagnosed at earlier stages and the most accepted classification for low-risk prostate cancer is based on clinical stage T1c or T2a, Gleason score <6, and prostate-specific antigen (PSA <10 ng/ml. METHODS: From 2005 to 2006, magnetic resonance imaging was performed in 42 patients, and transrectal ultrasound in 26 of these patients. Seven patients were excluded from the study. Mean patient age was 64.94 years and mean serum PSA was 6.05 ng/ml. The examinations were analyzed for tumor identification and location in prostate sextants, detection of extracapsular extension, and seminal vesicle invasion, using surgical pathology findings as the gold standard. RESULTS: Sixteen patients (45.7% had pathologically proven organ-confined disease, 11 (31.4% had positive surgical margin, 8 (28.9% had extracapsular extension, and 3 (8.6% presented with extracapsular extension and seminal vesicle invasion. Sensitivity, specificity, positive predictive value (PPV, negative predictive value (NPV and accuracy values for localizing low-risk prostate cancer were 53.1%, 48.3%, 63.4%, 37.8% and 51.3% for transrectal ultrasound; 70.4%, 36.2%, 65.1%, 42.0% and 57.7% for amplitude Doppler ultrasound; 71.5%, 58.9%, 76.6%, 52.4% and 67.1% for magnetic resonance imaging; 70.4%, 58.7%, 78.4%, 48.2% and 66.7% for magnetic resonance spectroscopy; 67.2%, 65.7%, 79.3%, 50.6% and 66.7% for dynamic contrast-enhanced magnetic resonance imaging, respectively. Sensitivity, specificity, PPV, NPV and accuracy values for detecting extracapsular extension were 33.3%, 92%, 14.3%, 97.2% and 89.7% for transrectal ultrasound and 50.0%, 77.6%, 13.7%, 95.6% and 75.7% for magnetic resonance imaging

  18. Transrectal EUS-guided FNA biopsy of a presacral chordoma-report of a case and review of the literature

    Institute of Scientific and Technical Information of China (English)

    Klaus Gottlieb; Paul H Lin; David M Liu; Karl Anders

    2008-01-01

    Chordomas are rare tumors which originate from the remnants of the notochord.These tumors are locally aggressive and have a predilection for the ends of the axial skeleton.An important prerequisite for optimal management of these tumors is a correct preoperative diagnosis.The present case is the first report of the use of endoscopic ultrasound to obtain transrectal fine needle aspiration biopsy of a presacral chordoma.A review of the prior computer tomography (CT) scans allowed us to calculate the tumor volume doubling time (18.3 mo).Transrectal biopsy of chordomas is controversial,however we believe that such concerns are not justified.

  19. Técnicas de biopsia para el diagnóstico de lesiones mamarias no palpables Biopsy techniques for the diagnosis of non-palpable mammary lesions

    Directory of Open Access Journals (Sweden)

    L. Pina

    2004-12-01

    Full Text Available Ante una lesión mamaria no palpable que precise una biopsia diagnóstica debe valorarse el método de guiado idóneo para acceder a la misma. En la actualidad se emplean tres métodos: la estereotaxia (fundamentalmente en casos de microcalcificaciones, la ecografía (sobre todo en los nódulos y la resonancia magnética (para lesiones no visibles mediante los anteriores sistemas. El siguiente paso es elegir la técnica de biopsia más adecuada. La técnica más clásica y fiable es la biopsia quirúrgica con marcaje previo con un arpón metálico, pero tiene los inconvenientes de ser una técnica agresiva para el diagnóstico de la patología benigna, además de presentar un alto coste. Como alternativas se han desarrollado múltiples sistemas de punción. La punción con aguja fina es de fácil realización técnica y puede dar buenos resultados en los nódulos mamarios, pero la existencia de resultados falsos positivos y negativos han limitado progresivamente su utilización. Como alternativa, los sistemas de biopsia con aguja gruesa han permitido la obtención de múltiples cilindros con gran fiabilidad diagnóstica, sobre todo en el caso de los nódulos mamarios. Sin embargo, su empleo en las microcalcificaciones continúa mostrando resultados falsos negativos. El advenimiento de los sistemas de biopsia asistida por vacío ha permitido la obtención de cilindros de mayor calidad, mejorando claramente los resultados de los sistemas anteriores, sobre todo en los casos de microcalcificaciones. Por último, los sistemas de biopsia escisional percutánea mediante cánulas de hasta 22 mm de diámetro consiguen la extracción completa de lesiones de tamaño inferior al de la cánula, con una fiabilidad similar al de la biopsia quirúrgica.Facing a non-palpable mammary lesion requiring a diagnostic biopsy, consideration must be given to the most suitable guiding method for obtaining the latter. Three methods are employed at present: stereotaxy

  20. Transrectal high-intensity focused ultrasound ablation of prostate cancer: Effective treatment requiring accurate imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Olivier.rouviere@netcourrier.com; Souchon, Remi [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: souchon@lyon.inserm.fr; Salomir, Rares [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: salomir@lyon.inserm.fr; Gelet, Albert [Hospices Civils de Lyon, Department of Urology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France)], E-mail: Albert.gelet@chu-lyon.fr; Chapelon, Jean-Yves [INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: chapelon@lyon.inserm.fr; Lyonnet, Denis [Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Pavillon P Radio, Hopital Edouard Herriot, F-69437 Lyon cedex 03 (France); Universite de Lyon, Lyon F-69003 (France); Universite de Lyon 1, Faculte de Medecine Lyon Nord, Lyon F-69003 (France); INSERM, Unit 556, 151 cours Albert Thomas, F-69424 Lyon cedex 03 (France)], E-mail: Denis.lyonnet@chu-lyon.fr

    2007-09-15

    Transrectal HIFU ablation has become a reasonable option for the treatment of localized prostate cancer in non-surgical patients, with 5-year disease-free survival similar to that of radiation therapy. It is also a promising salvage therapy of local recurrence after radiation therapy. These favourable results are partly due to recent improvements in prostate cancer imaging. However, further improvements are needed in patient selection, pre-operative localization of the tumor foci, assessment of the volume treated and early detection of recurrence. A better knowledge of the factors influencing the HIFU-induced tissue destruction and a better pre-operative assessment of them by imaging techniques should improve treatment outcome. Whereas prostate HIFU ablation is currently performed under transrectal ultrasound guidance, MR guidance with real-time operative monitoring of temperature will be available in the near future. If this technique will give better targeting and more uniform tissue destruction, its cost-effectiveness will have to be carefully evaluated. Finally, a recently reported synergistic effect between HIFU ablation and chemotherapy opens possibilities for treatment in high-risk or clinically advanced tumors.

  1. Transrectal Ultrasound Guided Biopsy of the Prostate: Is the Information Accessible, Usable, Reliable and Readable?

    Science.gov (United States)

    Redmond, Ciaran E.; Nason, Gregory J.; Kelly, Michael E.; McMahon, Colm; Cantwell, Colin P.; Quinlan, David M.

    2015-01-01

    Background/Aims To evaluate the accessibility, usability, reliability and readability of Internet information regarding transrectal ultrasound (TRUS) guided biopsy of the prostate. Materials and Methods The terms “prostate biopsy”, “TRUS biopsy” and “transrectal ultrasound guided biopsy of the prostate” were separately entered into the each of the top 5 most accessed Internet search engines. Websites were evaluated for accessibility, usability and reliability using the LIDA tool – a validated tool for the assessment of health related websites. Website readability was assessed using the Flesch Reading Ease Score and the Flesch Kincaid Grade Level. Results Following the application of exclusion criteria, 82 unique websites were analyzed. There was a significant difference in scores depending on authorship categories (p ≤ 0.001), with health related charity websites scoring highest (mean 122.29 ± 13.98) and non-academic affiliated institution websites scoring lowest (mean 87 ± 19.76). The presence of advertisements on a website was associated with a lower mean overall LIDA tool score (p = 0.024). Only a single website adhered to the National Institutes for Health recommendations on readability. Conclusions This study demonstrates variability in the quality of information available to Internet users regarding TRUS biopsies. Collaboration of website design and clinical acumen are necessary to develop appropriate websites for patient benefit. PMID:26195961

  2. Sonablate-500TM Transrectal High-intensity Focused Ultrasound (HIFU) for Benign Prostatic Hyperplasia Patients

    Institute of Scientific and Technical Information of China (English)

    L(U) Jun; HU Weilie; WANG Wei; ZHANG Yuanfeng; CHEN Zhaoyang; YE Zhangqun

    2007-01-01

    To evaluate the safety and efficacy of transrectal high-intensity focused ultrasound (HIFU) in the treatment of benign prostatic hyperplasia (BPH), serial studies were conducted in 150 BPH pa- tients before and 30 min, 1, 2, 6 and 12 month(s) after Sonablate-500TM HIFU treatment. A sili- con-coated indwelling 16F latex catheter was placed during the determination of the therapy zone. Preoperative and postoperative evaluations were made by using the international prostate symptom score (IPSS), quality of life (QOL), uroflowmetric findings and transrectal ultrasound, and incidence of complications. The cystourethrography was done in 23 patients within 1 year postoperatively. The results showed that after HIFU treatment, IPSS and QOL scores were significantly decreased at 1, 2, 6 and 12 month(s) (P<0.01). Maximum urine flow rate (6.0 to 17.2 mL/s, P<0.01), PVR (75.0 to 30.3,P<0.01) and prostatic volume (65.0 to 38.1 mL, P<0.05) were significantly improved 12 months after the operation. Recurrent urinary retention (n=2) and urethrorectal fistula (n=1) occurred at the 15th postoperative day. The duration of the HIFU prostate ablation was 25-90 rain. The mean time for an indwelling catheter was 3-19 days. These data demonstrate that treatment of BPH with Sonab- late-500TM HIFU is safe and effective.

  3. High-dose-rate prostate brachytherapy based on registered transrectal ultrasound and in-room cone-beam CT images

    NARCIS (Netherlands)

    Even, Aniek J.G.; Nuver, Tonnis T.; Westendorp, Hendrik; Hoekstra, Carel J.; Slump, C.H.; Minken, Andre W.

    2014-01-01

    Purpose To present a high-dose-rate (HDR) brachytherapy procedure for prostate cancer using transrectal ultrasound (TRUS) to contour the regions of interest and registered in-room cone-beam CT (CBCT) images for needle reconstruction. To characterize the registration uncertainties between the two ima

  4. Oncogenes E6-E7 de los Papilomavirus Humanos de alto riesgo detectados por PCR en Biopsias de pene incluidas en parafina

    OpenAIRE

    Guerrero, I; R Mejía; Velazco, R.; O Misad; M Pow-Sang

    1999-01-01

    La alta prevalencia del papilomavirus humano (PVH), referida a nivel mundial, en lesiones genitales de ambos sexos, el rol del varón como reservorio pasivo del virus, y el incremento de la mortalidad por cáncer genital en la mujer en nuestro país, motiva la detección y correlación de los oncogenes de los PVH de alto riesgo con la neoplasia de pene. Informamos de diez casos de biopsias de carcinoma escamoso de pene, incluidos en parafina, los cuales fueron investigados para la presencia de los...

  5. Mapeo linfático y biopsia del ganglio centinela en cáncer de pene. Estudio de factibilidad y reporte preliminar

    OpenAIRE

    Narciso Hernández-Toris; Joel Quintero-Becerra; José Francisco Gallegos-Hernández; Ramiro Flores-Ojeda; Isabel Alvarado-Cabrero; Donaciano Flores-López; Pablo Pichardo-Romero

    2007-01-01

    La mayoría de los pacientes con carcinoma epidermoide invasor de pene no tiene metástasis ganglionares inguinales al momento del diagnóstico; en 50 % de los ganglios palpables la causa es inflamatoria. El tratamiento del cáncer peneano implica resección del tumor primario y linfadenectomía inguinal, sin embargo, la morbilidad derivada del procedimiento es alta y la utilidad cuestionable en pacientes sin metástasis en ganglios disecados. El mapeo linfático con biopsia del ganglio centinela (ML...

  6. Descripción de los casos de nefropatía lúpica diagnosticados por biopsia en el Hospital Universitario del Valle, Cali, 1995-2000.

    OpenAIRE

    Rodrigo Villalobos; Pedro Rovetto; Armando Cortés; Consuelo Restrepo de Rovetto

    2009-01-01

    Se presenta un estudio descriptivo retrospectivo de 51 casos informados de nefropatía lúpica en el Departamento de Patología del Hospital Universitario del Valle, Cali, entre los años 1995 y 2000. Los casos fueron descritos según variables generales como sexo y grupo de edad al momento de la biopsia, diagnóstico histológico, grado de la nefropatía lúpica y puntajes del índice de actividad y cronicidad, según las definiciones aceptadas internacionalmente. Se hicieron comparaciones para determi...

  7. Factores predictivos de nefropatía no diabética en pacientes diabéticos. Utilidad de la biopsia renal

    OpenAIRE

    Bermejo García, Sheila; Soler, María José; Gimeno Beltran, Javier; Barrios Barrera, Clara; Rodríguez, Eva; Mojal, Sergio; Pascual Santos, Julio

    2016-01-01

    Antecedentes y objetivos: La afectación renal del diabético solo puede determinarse mediante biopsia renal, que presenta una elevada prevalencia de lesiones no diabéticas. Los objetivos del estudio fueron determinar la predictibilidad de nefropatía no diabética (NND) en diabéticos, estudiar diferencias de supervivencia y pronóstico renal, evaluar las lesiones histológicas en nefropatía diabética (ND) y el efecto de la proteinuria en la supervivencia y pronóstico renal en esta población. Mater...

  8. 3D transrectal ultrasound (TRUS) prostate segmentation based on optimal feature learning framework

    Science.gov (United States)

    Yang, Xiaofeng; Rossi, Peter J.; Jani, Ashesh B.; Mao, Hui; Curran, Walter J.; Liu, Tian

    2016-03-01

    We propose a 3D prostate segmentation method for transrectal ultrasound (TRUS) images, which is based on patch-based feature learning framework. Patient-specific anatomical features are extracted from aligned training images and adopted as signatures for each voxel. The most robust and informative features are identified by the feature selection process to train the kernel support vector machine (KSVM). The well-trained SVM was used to localize the prostate of the new patient. Our segmentation technique was validated with a clinical study of 10 patients. The accuracy of our approach was assessed using the manual segmentations (gold standard). The mean volume Dice overlap coefficient was 89.7%. In this study, we have developed a new prostate segmentation approach based on the optimal feature learning framework, demonstrated its clinical feasibility, and validated its accuracy with manual segmentations.

  9. Towards 3D ultrasound image based soft tissue tracking: a transrectal ultrasound prostate image alignment system

    CERN Document Server

    Baumann, Michael; Daanen, Vincent; Troccaz, Jocelyne

    2007-01-01

    The emergence of real-time 3D ultrasound (US) makes it possible to consider image-based tracking of subcutaneous soft tissue targets for computer guided diagnosis and therapy. We propose a 3D transrectal US based tracking system for precise prostate biopsy sample localisation. The aim is to improve sample distribution, to enable targeting of unsampled regions for repeated biopsies, and to make post-interventional quality controls possible. Since the patient is not immobilized, since the prostate is mobile and due to the fact that probe movements are only constrained by the rectum during biopsy acquisition, the tracking system must be able to estimate rigid transformations that are beyond the capture range of common image similarity measures. We propose a fast and robust multi-resolution attribute-vector registration approach that combines global and local optimization methods to solve this problem. Global optimization is performed on a probe movement model that reduces the dimensionality of the search space a...

  10. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management.

    Science.gov (United States)

    Fiaschetti, Valeria; Manenti, Guglielmo; Di Poce, Isabelle; Fornari, Maria; Ricci, Aurora; Finazzi Agrò, Enrico; Simonetti, Giovanni

    2012-01-01

    Colovesical fistula (CVF) is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF) is a possible but extremely rare complication of treatment of prostate cancer with "transrectal High-Intensity Focused Ultrasound (HIFU) treatment." We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan-with MPR, MIP, and VR reconstruction-before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  11. Evaluation of clinical efficacy of transrectal sonography and computed tomography for prostatic diseases

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Hiroki; Ohe, Hiroshi; Tanahashi, Toshikatsu and others

    1988-07-01

    Receiver operating characteristics (ROC) analysis was performed to evaluate the clinical efficacy of transrectal sonography (US) and computed tomography (CT) for prostatic diseases. One hundred US and CT images of prostatic diseases collected from 10 medical institutions, including 33 cases of prostatic cancer, 29 of benign prostatic hypertrophy, 7 of prostatitis, 2 of prostatic stone and 29 of normal finding, were read by 21 urologists. As the results, US was found to be more useful than CT for both the detection of prostatic diseases and the differentiation between prostatic cancer and benign prostatic hypertrophy. The sensitivity of US for the diagnosis of prostatic cancer was 64.2 % on average of all the urologists. However, the sensitivity was 80.0 % on average of 5 urologists who have read more than 3,000 US images and 59.5 % on average of 16 doctors who have read within 3,000 US images.

  12. A Rectourethral Fistula due to Transrectal High-Intensity Focused Ultrasound Treatment: Diagnosis and Management

    Directory of Open Access Journals (Sweden)

    Valeria Fiaschetti

    2012-01-01

    Full Text Available Colovesical fistula (CVF is an abnormal connection between the enteric and the urinary systems. The rectourethral fistula (RUF is a possible but extremely rare complication of treatment of prostate cancer with “transrectal High-Intensity Focused Ultrasound (HIFU treatment.” We present a case of CVF due to HIFU treatment of recurrent prostate cancer. The case was assessed with cystography completed with a pelvic CT scan—with MPR, MIP, and VR reconstruction—before emptying the bladder. Since the CT scan confirmed that the fistula involved solely the urethra and excluded even a minimal involvement of the bladder, it was possible to employ a conservative treatment by positioning a Foley catheter of monthly duration, in order to allow the urethra to rest. Still today, after 6 months, the patient is in a good clinical condition and has not shown yet signs of a recurrence of the fistula.

  13. Chorion biopsy in mongrel dogs Biopsia do cório fetal em cães

    Directory of Open Access Journals (Sweden)

    Guilherme J. Ferreira

    2009-10-01

    Full Text Available With the great development of the gestational studies in all of the species, we noticed the necessity of adaptations of these techniques for prenatal diagnosis in dogs. Based on this, we studied the feasibility of chorion biopsy guided by ultrasound. Our results demonstrated accuracy on the sex determination being 2 males and 12 females, as well as it would be possible to identify chromosome alteration due to the quality of samplings. Sex determination was accomplished with the identification of Y gene chromosomes in PCR technique. After the collection, fragments were prepared for light microscopy studies and revealed fetal chorion tissue, blood colloid and erythrocyte. In the whole material we found hemosiderin impregnations due to the hemolysis and to the residue of blood of the placental marginal hematomes. The submitted female dogs to this technique demonstrated normal puppy births without death.Com o grande desenvolvimento dos estudos gestacionais em todas as espécies, percebemos a necessidade de adaptarmos técnicas para diagnóstico pré-natal para cães. Assim, buscamos bases nas técnicas já existentes empregadas em humanos, e através destas, conseguimos estabelecer um método para coleta em cães, utilizando PCR para garantirmos a integridade das amostras. O procedimento foi realizado através de punção da cinta placentária com agulha de biopsia guiada por ultra-som. De todas as 14 amostras coletadas, duas apresentaram-se positivas para o cromossomo Y, presente apenas em machos, confirmando assim a viabilidade das amostras demonstrando com isso que através desta técnica podemos coletar material fetal para diagnóstico de alterações gênicas ou cromossômicas presentes nos cães antes mesmo destes virem a termo. A microscopia de material revelou fragmentos de cório fetal, colóide sangüíneo e eritrócitos. Em todo o material encontramos impregnações de hemosiderina devido à hemólise e ao resíduo de sangue dos hematomas

  14. Optical biopsy of the prostate: can we TRUST (trans-rectal ultrasound-coupled spectral tomography)?

    Science.gov (United States)

    Piao, Daqing; Jiang, Zhen; Bartels, Kenneth E.; Holyoak, G. Reed; Ritchey, Jerry W.; Rock, Kendra; Ownby, Charlotte L.; Bunting, Charles F.; Slobodov, Gennady

    2011-03-01

    Needle-based core-biopsy to locate prostate cancer relies heavily upon trans-rectal ultrasound (TRUS) imaging guidance. Ultrasonographic findings of classic hypoechoic peripheral zone lesions have a low specificity of ~28%, a low positive predictive value of ~29%, and an overall accuracy of ~43%, in prostate cancer diagnosis. The prevalence of isoechoic or nearly invisible prostate cancers on ultrasonography ranges from 25 to 42%. As a result, TRUS is useful and convenient to direct the needle trajectory following a systematic biopsy sampling template rather than to target only the potentially malignant lesion for focal-biopsy. To address this deficiency in the first-line of prostate cancer imaging, a trans-rectal ultrasound-coupled spectral tomography (TRUST) approach is being developed to non-invasively resolve the likely optical signatures of prostate malignancy. The approach has evolved from using one NIR wavelength to two NIR bands, and recently to three bands of NIR spectrum information. The concept has been evaluated on one normal canine prostate and three dogs with implanted prostate tumor developed as a model. The initial results implementing TRUST on the canine prostate tumor model includes: (1) quantifying substantially increased total hemoglobin concentration over the time-course of imaging in a rapidly growing prostate tumor; (2) confirming hypoxia in a prostatic cystic lesion; and (3) imaging hypoxic changes of a necrotic prostate tumor. Despite these interesting results, intensive technologic development is necessary for translating the approach to benefiting clinical practice, wherein the ultimate utility is not possibly to eliminate needle-biopsy but to perform focal-biopsy that is only necessary to confirm the cancer, as well as to monitor and predict treatment responses.

  15. Efficacy and cost analysis of transrectal ultrasound-guided prostate biopsy under monitored anesthesia

    Institute of Scientific and Technical Information of China (English)

    Sung Gu Kang; Bum Sik Tae; Sam Hong Mine; Young Hwu Ko; Seok Ho Kang; Jeong Gu Lee; Je Jong Kim; Jun Cheon

    2011-01-01

    @@ Sedation may result in reduction in pain during transrectal ultrasound(TRUS)-guided prostate biopsies.We aimed to evaluate the efficacy and safety of a combination of propofol and remifentanil infusion during TRUS-guided prostate biopsy and the related increases in health care costs.From January to September 2010,100 men undergoing a transrectal prostate biopsy were randomized into two groups.In Group 1,[50]patients received a combined infusion of propofol and remifentanil; in Group 2,[50]patients received lidocaine jelly.After TRUS-guided biopsies were performed,pain and patient satisfaction were evaluated by a 10-point visual analog scale (VAS),and a cost-related patient satisfaction questionnaire was completed by all patients.Patients were also asked whether they would be willing to undergo repeat biopsy by the same method.Patients in Group 1 showed a significantly lower VAS score than those in Group 2 (mean VAS score: 0.9士1.1 versus 6.312.5; P<0.001).In addition,the patient satisfaction scale was significantly higher in Group 1(P=0.002).Although the overall cost was significantly higher in Group 1(P=0.006),patient satisfaction scales considering cost were also higher in this group (P=0.009).A combination of propofol and remifentanil is a safe and effective way to decrease patient pain and increase patient satisfaction during TRUS-guided prostate biopsy.Although the costs were higher in the group that received sedation,as expected,the patients exhibited heightened satisfaction and willingness to repeat biopsies by the same method.

  16. Effectiveness of stress management in patients undergoing transrectal ultrasound-guided biopsy of the prostate

    Directory of Open Access Journals (Sweden)

    Chiu LP

    2016-02-01

    Full Text Available Li-Pin Chiu,1,2 Heng-Hsin Tung,3 Kuan-Chia Lin,3 Yu-Wei Lai,1,4 Yi-Chun Chiu,1,4 Saint Shiou-Sheng Chen,1,4 Allen W Chiu1,4 1Division of Urology, Taipei City Hospital, 2University of Taipei, General Education Center, 3School of Nursing, Department of Care Management, National Taipei University of Nursing and Health Science, 4Department of Urology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China Background: To assess the utilization of stress management in relieving anxiety and pain among patients who undergo transrectal ultrasound (TRUS-guided biopsy of the prostate.  Methods: Eighty-two patients admitted to a community hospital for a TRUS biopsy of the prostate participated in this case-controlled study. They were divided into an experimental group that was provided with stress management and a control group that received only routine nursing care. Stress management included music therapy and one-on-one simulation education. Before and after the TRUS biopsy, the patients’ state-anxiety inventory score, pain visual analogue scale (VAS, respiratory rate, heart rate, and blood pressure were obtained.  Results: There were no differences in baseline and disease characteristics between the two groups. The VAS in both groups increased after the TRUS biopsy, but the difference in pre- and postbiopsy VAS scores was significantly lower in the experimental group (P=0.03. Patients in both groups experienced mild anxiety before and after the biopsy, but those in the experimental group displayed a significantly greater decrease in postbiopsy state-anxiety inventory score compared to the control group (P=0.02.Conclusion: Stress management can alleviate anxiety and pain in patients who received a TRUS biopsy of the prostate under local anesthesia. Keywords: anxiety, pain, stress management, transrectal ultrasound-guided biopsy of the prostate

  17. Comparación entre las biopsias gástricas sin fijar 24 horas frente a la biopsia convencional para el diagnóstico de Helicobacter pylori en un hospital de referencia de Perú Comparison between gastric biopsies without fixation for 24 hours and conventional biopsy for the diagnosis of Helicobacter pylori in a reference hospital in Peru

    Directory of Open Access Journals (Sweden)

    César Tadeo Vela-Velásquez

    2011-03-01

    Full Text Available Objetivos. Comparar biopsias gástricas fijadas inmediatamente con formol al 10% frente a biopsias fijadas tras 24 horas en la detección de Helicobacter pylori (Hp en un hospital de referencia en Perú. Materiales y métodos. Se realizó un estudio de test diagnóstico sobre las biopsias gástricas de 72 pacientes que acudieron al Servicio de Gastroenterología del Hospital Essalud Alberto Sabogal en el Callao. Las muestras de cada paciente fueron repartidas en dos frascos de vidrio, una de ellas se fijó inmediatamente con formol al 10% y a la otra se fijó luego de 24 horas. Se procesaron ambos grupos de muestras con la técnica convencional de inclusión en parafina y coloración con hematoxilina-eosina. Resultados. Se evidenció Hp en 56,9% del grupo de biopsias fijadas inmediatamente y en el 79,2% del grupo de biopsias fijadas tras 24 horas, encontrándose diferencia estadística (pObjectives. To compare gastric biopsies immediately fixed with 10% formalin with biopsies fixed after 24 hours for the detection of Helicobacter pylori (Hp in a reference hospital in Peru. Materials and methods. A diagnostic test study on gastric biopsies from 72 patients attending the Gastroenterology service of hospital Essalud Alberto Sabogal in Callao was performed. Samples from each patient were divided into two glass jars, one of which was fixed immediately with 10% formalin and the other was fixed after 24 hours. Both groups of samples were processed with the conventional technique of paraffin embedding and staining with hematoxylin-eosin. Results. Hp was found in 56.9% of the group of biopsies which were inmediatly fixed and in 79.2% of the group of biopsies fixed after 24 hours, showing statistical difference (p <0.001. Conclusions. There is an increased frequency of diagnosis of Hp in the samples that were fixed after 24 hours, which may suggest that this would act as a biological culture for Hp, which would facilitate its diagnosis.

  18. Risk of prostate cancer diagnosis and mortality in men with a benign initial transrectal ultrasound-guided biopsy set

    DEFF Research Database (Denmark)

    Klemann, Nina; Røder, M Andreas; Helgstrand, J Thomas

    2017-01-01

    BACKGROUND: The risk of missing prostate cancer in the transrectal ultrasound-guided systematic biopsies of the prostate in men with suspected prostate cancer is a key problem in urological oncology. Repeat biopsy or MRI-guided biopsies have been suggested to increase sensitivity for diagnosis....... METHODS: Data were extracted from the Danish Prostate Cancer Registry-a population-based registry including all men undergoing histopathological assessment of prostate tissue. All men who were referred for transrectal ultrasound-guided biopsy for assessment of suspected prostate cancer between Jan 1, 1995......, and Dec 31, 2011, in Denmark were eligible for inclusion. Follow-up data were obtained on April 28, 2015. The primary endpoint was the cumulative incidence of prostate cancer-specific mortality, analysed in a competing risk setting, with death from other causes as the competing event. FINDINGS: Between...

  19. Characterization of prostate cancer, benign prostatic hyperplasia and normal prostates using transrectal 31phosphorus magnetic resonance spectroscopy: a preliminary report

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    Narayan, P.; Jajodia, P.; Kurhanewicz, J.; Thomas, A.; MacDonald, J.; Hubesch, B.; Hedgcock, M.; Anderson, C.M.; James, T.L.; Tanagho, E.A. (Univ. of California School of Medicine, San Francisco (USA))

    1991-07-01

    We assessed the ability of 31phosphorus (31P) transrectal magnetic resonance spectroscopy to characterize normal human prostates as well as prostates with benign and malignant neoplasms. With a transrectal probe that we devised for surface coil spectroscopy we studied 15 individuals with normal (5), benign hyperplastic (4) and malignant (6) prostates. Digital rectal examination, transrectal ultrasonography and magnetic resonance imaging were used to aid in accurate positioning of the transrectal probe against the region of interest within the prostate. The major findings of the in vivo studies were that normal prostates had phosphocreatine-to-adenosine triphosphate (ATP) ratios of 1.2 +/- 0.2, phosphomonoester-to-beta-ATP ratios of 1.1 +/- 0.1 and phosphomonoester-to-phosphocreatine ratios of 0.9 +/- 0.1. Malignant prostates had phosphocreatine-to-beta-ATP ratios that were lower (0.7 +/- 0.1) than those of normal prostates (p less than 0.02) or prostates with benign hyperplasia. Malignant prostates had phosphomonoester-to-beta-ATP ratios (1.8 +/- 0.2) that were higher than that of normal prostates (p less than 0.02). Using the phosphomonoester-to-phosphocreatine ratio, it was possible to differentiate metabolically malignant (2.7 +/- 0.3) from normal prostates (p less than 0.001), with no overlap of individual ratios. The mean phosphomonoester-to-phosphocreatine ratio (1.5 +/- 0.5) of prostates with benign hyperplasia was midway between the normal and malignant ratios, and there was overlap between individual phosphomonoester-to-phosphocreatine ratios of benign prostatic hyperplasia glands with that of normal and malignant glands. To verify the in vivo results, we performed high resolution magnetic resonance spectroscopy on perchloric acid extracts of benign prostatic hyperplasia tissue obtained at operation and on a human prostatic cancer cell line DU145.

  20. Identifying the variables associated with pain during transrectal ultrasonography of the prostate

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    Hou CP

    2015-08-01

    Full Text Available Chen-Pang Hou,1,2 Yu-Hsiang Lin,1,2 Meng-Chiao Hsieh,3 Chien-Lun Chen,1,2 Phei-Lang Chang,1,2 Ying-Chen Huang,2 Ke-Hung Tsui1,21Department of Urology, Chang Gung Memorial Hospital at Linkou, 2School of Medicine, Chang Gung University, 3Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan Objective: The purpose of this study was to prospectively investigate the degree of pain experienced by the patients receiving transrectal ultrasonography (TRUS of the prostate by applying a visual analog scale. We also identified the clinical parameters influencing pain during the TRUS examination.Materials and methods: Records were obtained from a prospective database for male patients who received TRUS of prostate in the outpatient department of Chang Gung Memorial Hospital, Taiwan, from January 2014 to June 2014. The patients underwent a detailed physical examination and medical history review. Immediately after the TRUS examination, the patients completed questionnaires based on a ten-point visual analog pain scale. The variables of interest were age, body mass index, prostate volume, prostate sagittal length, prostate-specific antigen, previous TRUS experience, external hemorrhoids, anal surgical history, prostate calcification, and image artifact caused by stool in the rectum. All variables were correlated to the visual analog scale by applying multivariate regression analysis.Results: By using linear regression analysis, we identified the independent factors that affected the pain score during the TRUS examination. The patients who received the examination for the first time or had longer prostate sagittal lengths, external hemorrhoids, anal surgical history, or stool stored in the rectum experienced more pain during the TRUS examination. Furthermore, the pain was reduced when we provided the patients with a detailed explanation before the procedure and

  1. The value and limitations of contrast-enhanced transrectal ultrasonography for the detection of prostate cancer

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    Zhao, Han-Xue, E-mail: zhaohx861@163.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Xia, Chun-Xia, E-mail: star9901482@163.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Yin, Hong-Xia, E-mail: hongxia_yin79@yahoo.com.cn [Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Guo, Ning, E-mail: ningguo99@sina.com.cn [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China); Zhu, Qiang, E-mail: qzhutrhos@gmail.com [Department of Diagnostic Ultrasound, Beijing Tongren Hospital, Capital Medical University, Dong-Jiao-Min-Xiang, Dong Cheng District, Beijing 100730 (China)

    2013-11-01

    Objectives: To evaluate the role of contrast-enhanced transrectal ultrasonography (CE-TRUS) for detecting prostate carcinoma. Methods: Sixty-five patients with elevated serum prostate-specific antigen (PSA) and/or abnormal digital rectal examination (DRE) were assessed using transrectal ultrasound (TRUS) and CE-TRUS. In all the patients, CE-TRUS was performed with intravenous injection of contrast agent (SonoVue, 2.4 ml) before biopsy. The cancer detection rates of the two techniques were compared. False-positive and false-negative findings related to CE-TRUS were analyzed in comparison to the pathological results of biopsy or radical prostatectomy. The targeted biopsy to abnormal CE-TRUS areas was also compared to systematic biopsy. Results: Prostate cancer was detected in 29 of the 65 patients. CE-TRUS showed rapid focal enhancement or asymmetric vessels of peripheral zones in 28 patients; 23 of them had prostate cancer. CE-TRUS had 79.3% sensitivity, compared to 65.5% of TRUS (P < 0.05). There were five false-positive and six false-negative findings from CE-TRUS. Benign prostate hyperplasia, and acute and chronic prostatitis were important causes related to the false-positive results of CE-TRUS. Prostate cancer originating from the transition zone or peripheral zone with lower PSA levels, small-size foci, and moderately or well-differentiated tumor was missed by CE-TRUS. The cancer detection rate of targeted biopsy (75%, 33/44 cores) was significantly higher than one of systematic biopsy (48.2%, 162/336) in those 28 cases (P < 0.05). In addition, no significant correlation was found between the cancer detection rate with CE-TRUS and serum PSA levels. Conclusion: CE-TRUS may improve the detection rate of prostate cancer through targeted biopsy of contrast-enhanced abnormalities. Our findings indicate that systematic biopsies should not be eliminated on the basis of false-positive and false-negative findings related to CE-TRUS.

  2. Granulomatous Prostatitis: Gray-scale Transrectal Ultrasonography and Color Doppler Ultrasonography Findings

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    Kim, Hyoung Jung; Lim, Joo Won; Lee, Dong Ho; Ko, Young Tae; Kim, Eui Jong [Kyung Hee University Medical Center, Seoul (Korea, Republic of)

    2007-12-15

    We report here three cases of granulomatous prostatitis. All cases were confirmed by a transrectal ultrasonography (TRUS)-guided core biopsy of the prostate. Two cases received intravesical BCG therapy for a bladder tumor, and one case had no known predisposing condition. Gray-scale TRUS showed low echoic nodules in the outer gland in all cases. Color Doppler ultrasonography (CDUS) showed several dot-like blood flows within the low echoic nodules in two cases and several dot-like blood flows and short linear blood flows within the low echoic nodules in one case. Gray-scale TRUS findings of granulomatous prostatitis are similar to findings of prostate cancer. On CDUS, several dot-like blood flows or short linear blood flows were noted within the low echoic nodules in patients with granulomatous prostatitis. If low echoic nodules with dot-like or short linear blood flows are noted in patients with genitourinary tract tuberculosis or previous BCG therapy, granulomatous prostatitis should be included in the differential diagnosis. However, a prostatic biopsy is required for a final diagnosis

  3. Rare complication after a transrectal ultrasound guided prostate biopsy: a giant retroperitoneal hematoma.

    Science.gov (United States)

    Chiancone, Francesco; Mirone, Vincenzo; Fedelini, Maurizio; Meccariello, Clemente; Pucci, Luigi; Carrino, Maurizio; Fedelini, Paolo

    2016-05-24

    Common complications related to transrectal ultrasound (TRUS) guided prostatic needle biopsy are hematuria, hematospermia, and hematochezia. To the best of our knowledge, we report the second case of a very large hematoma extending from the pelvis into the retroperitoneal space in literature.A 66-year-old man with a serum prostate-specific antigen (PSA) of 5.4 ng/ml was admitted to our department for a TRUS-guided prostatic needle biopsy. Laboratory values on the day before biopsy, including coagulation studies, were all normal. The patients did not take any anticoagulant drugs. No immediate complications were encountered. Nevertheless, 7 hours after the biopsy, the patient reached our emergency department with severe diffuse abdominal pain, hypotension, tachycardia, and confusional state. He underwent an ultrasonography and then a computed tomography (CT) scan that showed "a blood collection in the pelvis that extending to the lower pole of left kidney associated with a focus of active contrast extravasation, indicating active ongoing prostate bleeding." Consequently, he underwent a diagnostic angiography that showed no more contrast extravasation, without the need of embolization. Management of hematoma has been conservative and hematoma was completely reabsorbed 4 months later.

  4. Combining artificial neural networks and transrectal ultrasound in the diagnosis of prostate cancer.

    Science.gov (United States)

    Porter, Christopher R; Crawford, E David

    2003-10-01

    Arguably the most important step in the prognosis of prostate cancer is early diagnosis. More than 1 million transrectal ultrasound (TRUS)-guided prostate needle biopsies are performed annually in the United States, resulting in the detection of 200,000 new cases per year. Unfortunately, the urologist's ability to diagnose prostate cancer has not kept pace with therapeutic advances; currently, many men are facing the need for prostate biopsy with the likelihood that the result will be inconclusive. This paper will focus on the tools available to assist the clinician in predicting the outcome of the prostate needle biopsy. We will examine the use of "machine learning" models (artificial intelligence), in the form of artificial neural networks (ANNs), to predict prostate biopsy outcomes using prebiopsy variables. Currently, six validated predictive models are available. Of these, five are machine learning models, and one is based on logistic regression. The role of ANNs in providing valuable predictive models to be used in conjunction with TRUS appears promising. In the few studies that have compared machine learning to traditional statistical methods, ANN and logistic regression appear to function equivalently when predicting biopsy outcome. With the introduction of more complex prebiopsy variables, ANNs are in a commanding position for use in predictive models. Easy and immediate physician access to these models will be imperative if their full potential is to be realized.

  5. Complications and risk factors in transrectal ultrasound-guided prostate biopsies

    Directory of Open Access Journals (Sweden)

    Carlos Márcio Nóbrega de Jesus

    Full Text Available CONTEXT AND OBJECTIVE: Prostate biopsy is not a procedure without risk. There is concern about major complications and which antibiotics are best for routine use before these biopsies. The objective was to determine the rate of complications and the possible risk factors in prostate biopsies. DESIGN AND SETTING: Prospective study, Faculdade de Medicina de Botucatu. METHODS: Transrectal ultrasound (TRUS guided prostate biopsies were carried out in 174 patients presenting either abnormality in digital rectal examinations (DRE or levels higher than 4 ng/ml in prostate-specific antigen (PSA tests, or both. RESULTS: Hemorrhagic complications were the most common (75.3%, while infectious complications occurred in 19% of the cases. Hematuria was the most frequent type (56%. Urinary tract infection (UTI occurred in 16 patients (9.2%. Sepsis was observed in three patients (1.7%. The presence of an indwelling catheter was a risk factor for infectious complications (p < 0.05. Higher numbers of biopsies correlated with hematuria, rectal bleeding and infectious complications (p < 0.05. The other conditions investigated did not correlate with post-biopsy complications. CONCLUSIONS: Post-biopsy complications were mostly self-limiting. The rate of major complications was low, thus showing that TRUS guided prostate biopsy was safe and effective. Higher numbers of fragments taken in biopsies correlated with hematuria, rectal bleeding and infectious complications. An indwelling catheter represented a risk factor for infectious complications. The use of aspirin was not an absolute contraindication for TRUS.

  6. Comparison of Two Local Anesthesia Injection Methods During a Transrectal Ultrasonography-guided Prostate Biopsy

    Energy Technology Data Exchange (ETDEWEB)

    Baek, Song Ee; Oh, Young Taik [Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Jang Hwan; Rha, Koon Ho; Hong, Sung Joon; Yang, Seung Choul [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2010-09-15

    To compare the effectiveness of 2 injection methods of lidocaine during a transrectal ultrasound (TRUS)-guided prostate biopsy for pain control and complication rates. We retrospectively evaluated patients who underwent a TRUS-guided prostate biopsy from March 2005 to March 2006. One hundred patients were categorized into two groups based on injection method. For group 1, 10 mL of 1% lidocaine was injected bilaterally at the junction of the seminal vesicle and prostate and for group 2, into Denonvilliers' fascia. Pain scores using a visual analog scale (VAS) as well as immediate and delayed complication rates were evaluated. The mean VAS score showed no significant differences between the groups (group 1, 3.4{+-}1.78: group 2, 2.8{+-}1.3: p = 0.062). The difference in delayed complication rates and incidence of hematuria, hemospermia, and blood via the rectum was not significant between groups. However, two patients in group 1 complained of symptoms immediately after local anesthesia: one of tinnitus and the other of mild dizziness. There were no significant differences between pain control and complication rates between the 2 lidocaine injection methods. However, injection into Denonvilliers' fascia is thought to have less potential risk

  7. Transrectal ultrasound-guided biopsy of the prostate: aspirin increases the incidence of minor bleeding complications

    Energy Technology Data Exchange (ETDEWEB)

    Halliwell, O.T. [Department of Radiology, Southampton General Hospital, Southampton (United Kingdom)], E-mail: hallo99@doctors.org.uk; Yadegafar, G. [Public Health Sciences and Medical Statistics Division, School of Medicine, Southampton General Hospital, Southampton University, Southampton (United Kingdom); Lane, C.; Dewbury, K.C. [Department of Radiology, Southampton General Hospital, Southampton (United Kingdom)

    2008-05-15

    Aim: To assess whether patients taking aspirin were more likely to experience bleeding complications after transrectal ultrasound (TRUS)-guided prostate biopsy. Materials and methods: Three hundred and eighty-seven patients taking aspirin who underwent prostate biopsy over a 3.5 year period and 731 patients not taking aspirin over a 2 year period returned a questionnaire assessing the incidence and severity of bleeding complications. Results: Patients taking aspirin had a significantly higher cumulative incidence of haematuria and rectal bleeding, but not of haemospermia. They also had a longer mean duration of bleeding, but no increase in bleeding severity. Severe bleeding was very uncommon in both groups and no patients required intervention for bleeding complications. Conclusion: Aspirin exacerbates minor bleeding complications in patients undergoing TRUS guided biopsy of the prostate, but in this large group of aspirin-taking patients no dangerous bleeding complications were encountered. It may be that the risks associated with aspirin cessation outweigh the risks of haemorrhagic complications.

  8. Different optical spectral characteristics in a necrotic transmissible venereal tumor and a cystic lesion in the same canine prostate observed by triple-band trans-rectal optical tomography under trans-rectal ultrasound guidance

    Science.gov (United States)

    Jiang, Zhen; Holyoak, G. Reed; Ritchey, Jerry W.; Bartels, Kenneth E.; Rock, Kendra; Ownby, Charlotte L.; Slobodov, Gennady; Bunting, Charles F.; Piao, Daqing

    2011-03-01

    Different optical spectral characteristics were observed in a necrotic transmissible venereal tumor (TVT) and a cystic lesion in the same canine prostate by triple-wavelength trans-rectal optical tomography under trans-rectal ultrasound (TRUS) guidance. The NIR imager acquiring at 705nm, 785nm and 808nm was used to quantify both the total hemoglobin concentration (HbT) and oxygen saturation (StO2) in the prostate. The TVT tumor in the canine prostate as a model of prostate cancer was induced in a 7-year old, 27 kg dog. A 2 mL suspension of 2.5x106 cells/mL of homogenized TVT cells recovered from an in vivo subcutaneously propagated TVT tumor in an NOD/SCID mouse were injected in the cranial aspect of the right lobe of the canine prostate. The left lobe of the prostate had a cystic lesion present before TVT inoculation. After the TVT homogenate injection, the prostate was monitored weekly over a 9-week period, using trans-rectal NIR and TRUS in grey-scale and Doppler. A TVT mass within the right lobe developed a necrotic center during the later stages of this study, as the mass presented with substantially increased [HbT] in the periphery, with an area of reduced StO2 less than the area of the mass itself shown on ultrasonography. Conversely, the cystic lesion presented with slightly increased [HbT] in the periphery of the lesion shown on ultrasound with oxygen-reduction inside and in the periphery of the lesion. There was no detectable change of blood flow on Doppler US in the periphery of the cystic lesion. The slightly increased [HbT] in the periphery of the cystic lesion was correlated with intra-lesional hemorrhage upon histopathologic examination.

  9. Transrectal ultrasound-integrated spectral optical tomography of hypoxic progression of a regressing tumor in a canine prostate.

    Science.gov (United States)

    Jiang, Z; Piao, D; Bartels, K E; Holyoak, G R; Ritchey, J W; Ownby, C L; Rock, K; Slobodov, G

    2011-12-01

    The objective of this study was to evaluate if transrectal optical tomography implemented at three wavelength bands for spectral detection could monitor changes of the hemoglobin oxygen saturation (StO2) in addition to those of the total hemoglobin concentration ([HbT]) in lesions of a canine prostate, including an induced tumor modeling canine prostate cancer. Near-infrared (NIR) optical tomography was integrated with ultrasound (US) for transrectal imaging. Multi-spectral detection at 705_nm, 785_nm and 808_nm rendered measurements of [HbT] and StO2. Canine transmissible venereal tumor (TVT) cells were injected into the right lobe of a dog's prostate gland, which had a pre-existing cyst in the left lobe. Longitudinal assessments of the prostate were performed weekly over a 63-day duration by NIR imaging concurrent with grey-scale and Doppler US. Ultrasonography revealed a bi-lobular tumor-mass regressing from day-49 to day-63. At day-49 this tumor-mass developed a hypoxic core that became larger and more intense by day-56 and expanded further by day-63. The tumor-mass presented a strong hyper-[HbT] feature on day-56 that was inconsistent with US-visualized blood flow. Histology confirmed two necrotic TVT foci within this tumor-mass. The cyst appeared to have a large anoxic-like interior that was greater in size than its ultrasonographically delineated lesion, and a weak lesional elevation of [HbT]. On day-56, the cyst presented a strong hyper-[HbT] feature consistent with US-resolved blood flow. Histology revealed acute and chronic hemorrhage in the periphery of the cyst. The NIR imaging features of two other TVT nodules and a metastatic lymph node were evaluated retrospectively. Transrectal US-integrated spectral optical tomography seems to enable longitudinal monitoring of intra-lesional oxygenation dynamics in addition to the hemoglobin content of lesions in the canine prostate.

  10. The results of transperineal versus transrectal prostate biopsy: a systematic review and meta-analysis

    Institute of Scientific and Technical Information of China (English)

    Peng-Fei Shen; Yu-Chun Zhu; Wu-Ran Wei; Yong-Zhong Li; Jie Yang; Yu-Tao Li; Ding-Ming Li; Jia Wang; Hao Zeng

    2012-01-01

    This systematic review was performed to compare the efficacy and complications of transperineal (TP) vs.transrectal (TR) prostate biopsy.A systematic research of PUBMED,EMBASE and the Cochrane Library was performed to identify all clinical controlled trials on prostate cancer (PCa) detection rate and complications achieved by TP and TR biopsies.Prostate biopsies included sextant,extensive and saturation biopsy procedures.All patients were assigned to a TR group and a TP group.Subgroup analysis was performed according to prostate-specific antigen (PSA) levels and digital rectal examination (DRE) findings.The Cochrane Collaboration's RevMan 5.1 software was used for the meta-analysis.A total of seven trials,including three randomized controlled trials (RCTs) and four case- control studies (CCS),met our inclusion criteria.There was no significant difference in the cancer detection rate between the sextant TR and TP groups (risk difference (RD),-0.02; 95% confidence interval (Cl),-0.08-0.03; P=0.34).Meta-analysis for RCTs combined with CCS showed that there was no difference in the cancer detection rate between the extensive TR and TP group (RD,-0.01; 95% CI,-0.05-0.04; P=0.81).There was no significant difference in PCa detection rate between the saturation TR and TP approaches (31.4% vs.25.7%,respectively; P=0.3).There were also no significant differences in cancer detection between the TR and TP groups in each subgroup.Although the data on complications were not pooled for the meta-analysis,no significant difference was found when comparing TR and TP studies.TR and TP biopsies were equivalent in terms of efficiency and related complications.TP prostate biopsy should be an available and alternative procedure for use by urologists.

  11. THE PROGNOSTIC AND DIAGNOSTIC VALUE OF REPEATED TRANSRECTAL PROSTATE SATURATION BIOPSY

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    M. A. Kurdzhiev

    2014-08-01

    Full Text Available Objective: to determine the rate of prostate cancer (PC development after repeated transrectal saturation prostate biopsy (RTRSPB, to study the characteristics of diagnosed tumors, and to estimate their clinical significance from the data of radical retropubic prostatectomy (RRP.Materials and methods. The results of RTRSPB were analyzed in 226 patients with a later evaluation of a tumor from the results of RRP. All the patients underwent at least 2 prostate biopsies (mean 2.4. The average number of biopsy cores was 26.7 (range 24—30. The average value of total prostate-specific antigen before saturation biopsy was 7.5 (range 7.5 to 28.6 ng/ml. The mean age of patients was 62 years (range 53 to 70.  Results. PC was diagnosed in 14.6% of cases (33/226. An isolated lesion of the prostatic transition zone was in 12.1% of cases. If this zone had been excluded from the biopsy scheme, the detection rate of PC during saturation biopsy should be reduced by 13.8%. Better PC detectability during repeated saturation biopsy generally occurred due to the localized forms of the disease (93.3%. The agreement of Gleason tumor grading in the biopsy and prostatectomy specimens was noted in 66.7% of cases.Conclusion. Saturation biopsy allows prediction of a pathological stage of PC, Gleason grade of a tumor and its site localization with a greater probability. Most tumors detectable by saturation biopsy were clinically significant, which makes it possible to recommend RTRSPB to some cohort of high PC-risk patients 

  12. Comparative Effectiveness of Single versus Combination Antibiotic Prophylaxis for Infections after Transrectal Prostate Biopsy.

    Science.gov (United States)

    Marino, Kaylee; Parlee, Anne; Orlando, Ralph; Lerner, Lori; Strymish, Judith; Gupta, Kalpana

    2015-12-01

    An increase in fluoroquinolone resistance and transrectal ultrasound-guided prostate (TRUS) biopsy infections has prompted the need for alternative effective antibiotic prophylaxis. We aimed to compare ciprofloxacin and other single-agent therapies to combination therapy for efficacy and adverse effects. Men who underwent a TRUS biopsy within the VA Boston health care system with documented receipt of prophylactic antibiotics periprocedure were eligible for inclusion. Postprocedure infections within 30 days were ascertained by chart review from electronic records, including any inpatient, outpatient, or urgent-care visits. Among 455 evaluable men over a 3-year period, there were 25 infections (5.49%), with sepsis occurring in 2.4%, urinary tract infections (UTI) in 1.54%, and bacteremia in 0.44% of patients. Escherichia coli was the most common urine (89%) and blood (92%) pathogen, with fluoroquinolone resistance rates of 88% and 91%, respectively. Ciprofloxacin alone was associated with significantly more infections than ciprofloxacin plus an additional agent (P = 0.014). Intramuscular gentamicin alone was also significantly associated with a higher infection rate obtained with all other regimens (P = 0.004). Any single-agent regimen, including ciprofloxacin, ceftriaxone, or gentamicin, was associated with significantly higher infection rates than any combination regimen (odds ratio [OR], 4; 95% confidence interval [CI], 1.47, 10.85; P = 0.004). Diabetes, immunosuppressive condition or medication, hospitalization within the previous year, and UTI within the previous 6 months were not associated with infection risk. Clostridium difficile infections were similar. These findings suggest that ciprofloxacin, ceftriaxone, and gentamicin alone are inferior to a combination regimen. Institutions with high failure rates of prophylaxis for TRUS biopsies should consider combination regimens derived from their local data.

  13. The effectivity of periprostatic nerve blockade for the pain control during transrectal ultrasound guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Alper Otunctemur

    2013-06-01

    Full Text Available Aim: Transrectal ultrasound (TRUS guided prostete biopsy is accepted as a standard procedure in the diagnosis of prostate cancer. Many different protocoles are applied to reduce the pain during the process. In this study we aimed to the comparison of two procedure with intrarectal lidocaine gel and periprostatice nerve blockade respective- ly in addition to perianal intrarectal lidocaine gel on the pain control in prostate biop- sy by TRUS. Methods: 473 patients who underwent prostate biopsy guided TRUS between 2008-2012 were included in the study. 10-point linear visual analog pain scale(VAS was used to evaluate the pain during biopsy. The patients were divided into two groups according to anesthesia procedure. In Group 1, there were 159 patients who had perianal-intrarectal lidocaine gel, in Group 2 there were 314 patients who had periprostatic nerve blockade in addition to intrarectal lidocain gel. The pain about probe manipulation was aseesed by VAS-1 and during the biopsy needle entries was evalu- ated by VAS-2. Results were compared with Mann-Whitney U and Pearson chi-square test. Results: Mean VAS-2 scores in Group 1 and Group 2 were 4.54 ± 1.02 and 2.06 ± 0.79 respectively. The pain score was determined significantly lower in the Group 2 (p = 0.001. In both groups there was no significant difference in VAS-1 scores, patient’s age, prostate volume, complication rate and PSA level. Conclusion: The combination of periprostatic nerve blockade and intrarectal lidocain gel provides a more meaningful pain relief compared to group of patients undergoing intrarectal lidocaine gel.

  14. Automatic localization of the da Vinci surgical instrument tips in 3-D transrectal ultrasound.

    Science.gov (United States)

    Mohareri, Omid; Ramezani, Mahdi; Adebar, Troy K; Abolmaesumi, Purang; Salcudean, Septimiu E

    2013-09-01

    Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical system is the current state-of-the-art treatment option for clinically confined prostate cancer. Given the limited field of view of the surgical site in RALRP, several groups have proposed the integration of transrectal ultrasound (TRUS) imaging in the surgical workflow to assist with accurate resection of the prostate and the sparing of the neurovascular bundles (NVBs). We previously introduced a robotic TRUS manipulator and a method for automatically tracking da Vinci surgical instruments with the TRUS imaging plane, in order to facilitate the integration of intraoperative TRUS in RALRP. Rapid and automatic registration of the kinematic frames of the da Vinci surgical system and the robotic TRUS probe manipulator is a critical component of the instrument tracking system. In this paper, we propose a fully automatic registration technique based on automatic 3-D TRUS localization of robot instrument tips pressed against the air-tissue boundary anterior to the prostate. The detection approach uses a multiscale filtering technique to identify and localize surgical instrument tips in the TRUS volume, and could also be used to detect other surface fiducials in 3-D ultrasound. Experiments have been performed using a tissue phantom and two ex vivo tissue samples to show the feasibility of the proposed methods. Also, an initial in vivo evaluation of the system has been carried out on a live anaesthetized dog with a da Vinci Si surgical system and a target registration error (defined as the root mean square distance of corresponding points after registration) of 2.68 mm has been achieved. Results show this method's accuracy and consistency for automatic registration of TRUS images to the da Vinci surgical system.

  15. Correlation of transrectal ultrasonographic findings of the prostate with the occurrence of detrusor instability in patients with benign prostatic hyperplasia.

    Science.gov (United States)

    Tong, Y C; Lin, Y M; Yang, W H; Tzai, T S; Lin, J S

    1995-01-01

    Forty patients with benign prostatic hyperplasia were evaluated with urodynamics and transrectal ultrasonography. Seventeen patients were found to have detrusor instability while the remaining 23 did not. No significant differences were noted during ultrasonography in the estimated prostatic volume, the presumed circle area ratio and the incidence of finding prostatic calcification between these two groups. However, the incidence of detecting intravesical protrusion of the prostate is significantly higher in patients with instability than in patients with stable bladder (53 vs. 13%, p prostate and alter the stability status of the urinary bladder.

  16. Transrectal ultrasonography-guided transperineal bilateral seminal vesicle puncture and continuous irrigation for the treatment of intractable hematospermia

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xin-ru; GU Bao-jun; XU Yue-min; CHEN Rong; ZHANG Jiong; QIAO Yong

    2008-01-01

    @@ Hematospermia is a rare condition, but often causes frustration. The reason for this frustration is that the exact incidence of hematospermia remains unknown and its cause is difficult to determine.1 Many reports in the past decades have focused on the etiology of hematospermia.2 Hematospermia is treated initially by administration of antibiotics, coagulants, and sex steroid hormones. However, some cases may prove resistant to this therapy and the condition may continue. For some intractable and agnogenic cases, the therapeutic strategy mentioned above is not very effective. Recently, we treated 63 such nonresponsive patients by direct continuous antibiotic irrigation into the bilateral seminal vesicles through puncture under transrectal ultrasonography (TRUS) guidance.

  17. Resultados de biopsia guiada por tomografía axial computarizada en el síndrome de destrucción vertebral, evaluados en dos instituciones distintas

    Directory of Open Access Journals (Sweden)

    Barón Zarate-Kalfopulos

    2013-01-01

    Full Text Available OBJETIVO: Comparar resultados de biopsias vertebrales guiadas por tomografía axial computarizada, reportados por dos servicios de Anatomía Patológica distintos en pacientes con síndrome de destrucción vertebral para confirmar confiabilidad y utilidad en el diagnóstico. MÉTODOS: Se obtuvieron muestras de tejido de 21 pacientes en el periodo comprendido del 1 de marzo al 15 de julio del 2011 con el diagnóstico del síndrome de destrucción vertebral y a quienes se les realizó biopsia guiada por tomografía axial computarizada. Las muestras se enviaron en forma cegada a dos servicios de patología distintos. Los resultados fueron analizados con el método de comparación de dos proporciones. RESULTADOS: 14 pacientes fueron del género masculino (67% y 7 del femenino (23%, edades de 28-82, con afección principalmente lumbar (48% y torácica (38%; afectados en una vértebra en 62%, en dos en un 33% y en 3 o más niveles en 5%. Las vértebras más afectadas fueron L1, L2 y L3 (12/30 [40%], T4 (3/30 [10%] y T9 (3/30 [10%]. Los resultados se agruparon en categorías: 1. Osteomielitis (9/21 [43%], 2. Tumores (7/21 [33%], 3. Metástasis (3/21 [14%], 4. Tejido normal (2/21 [10%], 5. Inflamación (0/21 [0%], 6. Muestra inadecuada (0/21 [0%], 7. Mal de Pott (0/21 [0%]. CONCLUSIONES: De acuerdo a los valores de Z obtenidos mediante la prueba de comparación de dos proporciones no se encontró diferencia significativa entre los resultados reportados por dos los dos servicios de patología en el síndrome estudiado, determinándose que esta parte del proceso es confiable y útil en un 90%.

  18. The Accuracy of Prostate Cancer Localization Diagnosed on Transrectal Ultrasound-Guided Biopsy Compared to 3-Dimensional Transperineal Approach

    Directory of Open Access Journals (Sweden)

    Kevin Krughoff

    2013-01-01

    Full Text Available Background. Prostate cancer is often understaged following 12-core transrectal ultrasound- (TRUS- guided biopsies. Our goal is to understand where cancers are typically missed by this method. Methods. Transperineal 3-dimensional mapping biopsy (3DMB provides a more accurate depiction of disease status than transrectal ultrasound- (TRUS- guided biopsy. We compared 3DMB findings in men with prior TRUS-guided biopsies to determine grade and location of missed cancer. Results were evaluated for 161 men with low-risk organ confined prostate cancer. Results. The number of cancer-positive biopsy zones per patient with TRUS was 1.38 ± 1.21 compared to 3.33 ± 4.06 with 3DMB, with most newly discovered cancers originating from the middle lobe and apex. Approximately half of all newly discovered cancerous zones resulted from anterior 3DMB sampling. Gleason upgrade was recognized in 56 patients using 3DMB. When both biopsy methods found positive cores in a given zone, Gleason upgrades occurred most frequently in the middle left and right zones. TRUS cancer-positive zones not confirmed by 3DMB were most often the basal zones. Conclusion. Most cancer upgrades and cancers missed from TRUS biopsy originated in the middle left zone of the prostate, specifically in anterior regions. Anterior sampling may lead to more accurate diagnosis and appropriate followup.

  19. Postprostatectomy ultrasound-guided transrectal implantation of gold markers for external beam radiotherapy. Technique and complications rate

    Energy Technology Data Exchange (ETDEWEB)

    Langenhuijsen, J.F.; Kiemeney, L.A.L.M.; Witjes, J.A. [Radboud Univ. Nijmegen Medical Center, Nijmegen (Netherlands). Dept. of Urology; Donker, R. [Medical Center Alkmaar (Netherlands). Dept. of Radiation Oncology; McColl, G.M.; Lin, E.N.J.T. van [Radboud Univ. Nijmegen Medical Center, Nijmegen (Netherlands). Dept. of Radiation Oncology

    2013-06-15

    Background and purpose: Postprostatectomy radiotherapy (RT) improves survival in adjuvant and salvage settings. The implantation technique and complications rate of gold markers in the prostate bed for high-precision RT were analyzed. Patients and methods: Patients undergoing postprostatectomy RT for prostate-specific antigen (PSA) relapse or high-risk disease were enrolled in the study. Under transrectal ultrasound guidance, three fine gold markers were implanted in the prostate bed and the technical difficulties of insertion were documented. Patients received our self-designed questionnaires concerning complications and pain. The influence of anticoagulants and coumarins on bleeding was analyzed, as was the effect of potential risk factors on pain. Results: In 77 consecutive patients, failure of marker implantation or marker migration was seen in six cases. Rectal bleeding was reported by 10 patients and 1 had voiding complaints. No macroscopic hematuria persisting for more than 3 days was observed. Other complications included rectal discomfort (n = 2), nausea (n = 1), abdominal discomfort (n = 1), and pain requiring analgesics (n = 4). No major complications were reported. On a 0-10 visual analogue scale (VAS), the mean pain score was 3.7. No clinically significant risk factors for complications were identified. Conclusion: Transrectal implantation of gold markers in the prostate bed is feasible and safe. Alternatives like cone beam computed tomography (CBCT) should be considered, but the advantages of gold marker implantation for high-precision postprostatectomy RT would seem to outweigh the minor risks involved. (orig.)

  20. Detección inmunohistoquímica de la proteína L1 de Virus Papiloma Humano (HPV) de alto riesgo en citologías y biopsias de cuello uterino

    OpenAIRE

    Toro, Morelva; Llombart Bosch, Antonio

    2005-01-01

    Para confirmar la detección inmunohistoquímica de la proteína L1 de HPV de alto riesgo, tanto en citologías con anormalidades en células epiteliales como en biopsias con diagnóstico de carcinoma epidermoide cervical, se seleccionaron aleatoriamente: 11 citologías cervicales del año 2004 con interpretación citológica de anormalidades en células escamosas incluyendo: células escamosas atípicas y lesión intraepitelial escamosa de bajo y alto grado y 50 biopsias de cérvix con carcinoma epidermoid...

  1. Patient information leaflets for Transrectal Ultrasound guided prostate biopsy: Results of North Thames deanery survey

    Directory of Open Access Journals (Sweden)

    Phipps Claire

    2010-01-01

    Full Text Available Abstract Background We evaluated the quality of patient information leaflets for Trans-Rectal Ultrasound guided prostate biopsies (TRUS-Bx in North Thames region. TRUS-Bx information leaflets were requested from 24 hospitals in the region. All hospitals were contacted by telephone, and non-responders were followed-up by postal survey. Leaflets received were evaluated for a clear description of the procedure, directions to TRUS-Bx location, a clear description of the procedure, contact for queries/concerns, information about preparation prior to procedure, information about regular medication, information on how to obtain results, instructions for follow-up arrangements, analgesia used and risk of morbidity/mortality. Additionally, the leaflets were evaluated for diagrams to clarify the procedure and the anatomy, and sources of additional information, such as reference to published articles or prostate cancer patient support groups/internet websites. Findings In summary, a total of 17 leaflets (77% were received. Of these, the majority (94% had a clear description of the procedure, contact for queries/concerns (82%, information about preparation prior to TRUS-Bx (71%. Directions to TRUS-Bx location (29%, and analgesia used (35%, was very poorly described, and information on obtaining results and follow-up arrangements were described in only 12 (71% leaflets. Complications such as risks of infection, haematuria, haematospermia and rectal bleeding, were generally explained (71%-76% of leaflets, urinary retention was mentioned in only 5 (29% leaflets and mortality in only 1 case. Descriptive diagrams of the procedure and prostate anatomy were very rarely used, and sources of additional information were limited to 1 published article and reference to 1 prostate cancer support group. Conclusions This study demonstrates that there is large variation in the information supplied in TRUS-Bx patient information leaflets in the North Thames region, with

  2. Fully automated prostate magnetic resonance imaging and transrectal ultrasound fusion via a probabilistic registration metric

    Science.gov (United States)

    Sparks, Rachel; Bloch, B. Nicholas; Feleppa, Ernest; Barratt, Dean; Madabhushi, Anant

    2013-03-01

    In this work, we present a novel, automated, registration method to fuse magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) images of the prostate. Our methodology consists of: (1) delineating the prostate on MRI, (2) building a probabilistic model of prostate location on TRUS, and (3) aligning the MRI prostate segmentation to the TRUS probabilistic model. TRUS-guided needle biopsy is the current gold standard for prostate cancer (CaP) diagnosis. Up to 40% of CaP lesions appear isoechoic on TRUS, hence TRUS-guided biopsy cannot reliably target CaP lesions and is associated with a high false negative rate. MRI is better able to distinguish CaP from benign prostatic tissue, but requires special equipment and training. MRI-TRUS fusion, whereby MRI is acquired pre-operatively and aligned to TRUS during the biopsy procedure, allows for information from both modalities to be used to help guide the biopsy. The use of MRI and TRUS in combination to guide biopsy at least doubles the yield of positive biopsies. Previous work on MRI-TRUS fusion has involved aligning manually determined fiducials or prostate surfaces to achieve image registration. The accuracy of these methods is dependent on the reader's ability to determine fiducials or prostate surfaces with minimal error, which is a difficult and time-consuming task. Our novel, fully automated MRI-TRUS fusion method represents a significant advance over the current state-of-the-art because it does not require manual intervention after TRUS acquisition. All necessary preprocessing steps (i.e. delineation of the prostate on MRI) can be performed offline prior to the biopsy procedure. We evaluated our method on seven patient studies, with B-mode TRUS and a 1.5 T surface coil MRI. Our method has a root mean square error (RMSE) for expertly selected fiducials (consisting of the urethra, calcifications, and the centroids of CaP nodules) of 3.39 +/- 0.85 mm.

  3. [Improvement of transrectal ultrasound. Artificial neural network analysis (ANNA) in detection and staging of prostatic carcinoma].

    Science.gov (United States)

    Loch, T; Leuschner, I; Genberg, C; Weichert-Jacobsen, K; Küppers, F; Retz, M; Lehmann, J; Yfantis, E; Evans, M; Tsarev, V; Stöckle, M

    2000-07-01

    As a result of the enhanced clinical application of prostate specific antigen (PSA), an increasing number of men are becoming candidates for prostate cancer work-up. A high PSA value over 20 ng/ml is a good indicator of the presence of prostate cancer, but within the range of 4-10 ng/ml, it is rather unreliable. Even more alarming is the fact that prostate cancer has been found in 12-37% of patients with a "normal" PSA value of under 4 ng/ml (Hybritech). While PSA is capable of indicating a statistical risk of prostate cancer in a defined patient population, it is not able to localize cancer within the prostate gland or guide a biopsy needle to a suspicious area. This necessitates an additional effective diagnostic technique that is able to localize or rule out a malignant growth within the prostate. The methods available for the detection of these prostate cancers are digital rectal examination (DRE) and Transrectal ultrasound (TRUS). DRE is not suitable for early detection, as about 70% of the palpable malignancies have already spread beyond the prostate. The classic problem of visual interpretation of TRUS images is that hypoechoic areas suspicious for cancer may be either normal or cancerous histologically. Moreover, about 25% of all cancers have been found to be isoechoic and therefore not distinguishable from normal-appearing areas. None of the current biopsy or imaging techniques are able to cope with this dilemma. Artificial neural networks (ANN) are complex nonlinear computational models, designed much like the neuronal organization of a brain. These networks are able to model complicated biologic relationships without making assumptions based on conventional statistical distributions. Applications in Medicine and Urology have been promising. One example of such an application will be discussed in detail: A new method of Artificial Neural Network Analysis (ANNA) was employed in an attempt to obtain existing subvisual information, other than the gray scale

  4. Doença de Lafora: diagnóstico pela biopsia de músculo esquelético (relato de caso Lafora's disease: diagnosis by muscle biopsy (case report

    Directory of Open Access Journals (Sweden)

    ALZIRA ALVES DE SIQUEIRA CARVALHO

    2000-12-01

    Full Text Available Uma paciente de 16 anos apresentava epilepsia mioclônica causada pela doença de Lafora. A biopsia muscular mostrou padrão vacuolar nas fibras musculares com as reações nicotinamida adenina tetrazolium redutase desidrogenase, hematoxilina-eosina e PAS. O aspecto morfológico permite o diagnóstico através da biopsia muscular. Este é um procedimento menos agressivo que a biopsia de fígado e de cérebro. A microscopia eletrônica deve ser reservada para casos nos quais as alterações musculares à microscopia óptica são muito discretas deixando dúvidas quanto ao diagnóstico.A 16-year-old female patient had myoclonic epilepsy caused by Lafora's disease. Muscle biopsy showed a prominent splitting pattern in muscle fibers with the nicotinamide adenine nucleotide dehydrogenase-tetrazolium reductase reaction, hematoxylin-eosin, and PAS stains. This morphologic appearance of the tissue permits diagnosis using the benign technique of muscle biopsy. The ultrastructural examination of muscle may be necessary to confirm the diagnosis of Lafora myoclonus epilepsy if light microscopical findings are equivocal.

  5. Biopsia hepática em cães: relação entre qualidade da amostra e grau de conclusão do diagnóstico

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    Tostes R.A.

    2002-01-01

    Full Text Available O presente estudo objetivou analisar a qualidade do diagnóstico de biopsias colhidas com agulhas tipo aspirativa e cortante, comparando-as ao exame histológico post-mortem do fígado de cães portadores de afecções hepáticas. Foram utilizados 60 cães, sem distinção de sexo, raça ou idade. As biopsias foram procedidas com agulhas tipo MenghiniÒ (de natureza aspirativa e agulhas tipo Tru-CutÒ (de natureza cortante. As biopsias foram colhidas utilizando-se a técnica percutânea transabdominal. O diagnóstico referente à agulha tipo Tru-CutÒ não diferiu do diagnóstico referente à agulha tipo MenghiniÒ. O referente à agulha tipo Tru-CutÒ foi o que apresentou maior índice de concordância, 88,3% de acertos. A agulha tipo Tru-CutÒ apresentou excelentes resultados independente da natureza das lesões, enquanto que a agulha tipo MenghiniÒ falhou nos casos de fibrose.

  6. Descripción de los casos de nefropatía lúpica diagnosticados por biopsia en el Hospital Universitario del Valle, Cali, 1995-2000.

    Directory of Open Access Journals (Sweden)

    Rodrigo Villalobos

    2009-11-01

    Full Text Available Se presenta un estudio descriptivo retrospectivo de 51 casos informados de nefropatía lúpica en el Departamento de Patología del Hospital Universitario del Valle, Cali, entre los años 1995 y 2000. Los casos fueron descritos según variables generales como sexo y grupo de edad al momento de la biopsia, diagnóstico histológico, grado de la nefropatía lúpica y puntajes del índice de actividad y cronicidad, según las definiciones aceptadas internacionalmente. Se hicieron comparaciones para determinar si existían diferencias en cuanto a las tendencias descritas entre las poblaciones pediátrica y adulta, encontrándose que los pacientes de 15 años y menos no muestran nefropatías de grados más graves, ni presentan índices de actividad y cronicidad peores que los adultos; sin embargo, estos datos no son estadísticamente significativos.

  7. Treatment of anastomotic leakage after rectal resection with transrectal vacuum-assisted drainage (VAC). A method for rapid control of pelvic sepsis and healing

    DEFF Research Database (Denmark)

    Nagell, Carl Frederik Otto; Holte, Kathrine

    2006-01-01

    OBJECTIVE: Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor fun...

  8. COMPLEX TRANSRECTAL US WITH COLOR FLOW MAPPING, DOPPLER SONOGRAPHY AND SONOELASTOGRAFIEY IN PROSTATE CANCER EVALUATION

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    А. I. Mukhomor

    2014-07-01

    Full Text Available Oncology statistics shows steady increase of prostate cancer, since early diagnosis and adequate treatment are crucial. Among prostate imaging modalities sonoelastography (SEG has a special value for identifying suspicious dense foci in prostate, however more studies are still required to establishing accuracy and specificity with different SEG techniques for updating the prostate cancer diagnostics protocol.The aim of study was to evaluate sonoelastography capabilities for ultrasound guided prostate biopsy, comparing with gray scale and Doppler modalities.512 consecutively selected patients were examined (mean age of 56 years, mean prostate volume was 54 cm3, the average PSA about 14.3 ng/ml. All patients underwent prostate cancer diagnostic algorithm, including direct rectal exam, PSA level, transrectal ultrasound (TRUS with Doppler and SEG identification of suspicious foci, mostly in peripheral zones, followed by 10-point biopsy guided by ultrasound. According to aim we assigned patients to 4 groups: group 1 (n = 327 underwent gray scale and Doppler US guided prostate biopsy; in patients of group 2 (n = 106 – additionally SEG was applied (3 patients of this group was also performed MRI and MRS of the prostate; in group 3 there were patients with high level of PSA and negative TRUS guided biopsy; group 4 – of 41 patiens with prostatectomy and biochemical recidive of prostate.Among 430 cases included to this study in 318 patients (74 % prostate adenocarcinoma was revealed, in 270 (63 % patients – benign hyperplasia (BH. In group 1 cancer was diagnosed in 236 (72.1 ± 2.4 % patients, in group 2 – in 84 (79.2 ± 3.8 %. 19 false negative and 6 false positive results were registered in SEG enchanced US guided prostate biopsy. Routine TRUS indicate lesions with mean sizes about 0.8 ± 0,21 sm in compare with 0,5 ± 0,08 sm which were diagnose by SEG. Locuses which were marked as benign byTRUS with SEG hade never conatained neoplastic cells

  9. A multi-classifier system for the characterization of normal, infectious, and cancerous prostate tissues employing transrectal ultrasound images.

    Science.gov (United States)

    Glotsos, Dimitris; Kalatzis, Ioannis; Theocharakis, Pantelis; Georgiadis, Pantelis; Daskalakis, Antonis; Ninos, Kostas; Zoumboulis, Pavlos; Filippidou, Anna; Cavouras, Dionisis

    2010-01-01

    A computer-aided diagnostic system has been developed for the discrimination of normal, infectious and cancer prostate tissues based on texture analysis of transrectal ultrasound images. The proposed system has been designed using a panel of three classifiers, which have been evaluated individually or as a mutli-classifier scheme, using the external cross-validation procedure. Clinical data consisted of 165 transrectal ultrasound images, characterized by an experienced physician as normal (55/165), cancerous (55/165), and infectious (55/165) prostate cases. From each image, the physician delineated the most representative regions of interest, from which, 23 textural features were extracted. Classification was seen as a two level hierarchical decision tree. Normal from infectious and infectious from cancer cases were discriminated at the 1st and 2nd level of the decision tree, respectively. The best classification results for the 1st level were 89.5%, whereas for the 2nd level 90.1%. The utilization of multi-classifier system improved the discrimination of prostate pathologies as compared to individual classifiers; for infectious prostate cases improvement was from 87.3% to 88.7% and for cancer prostate cases improvement was from 84.1% to 91.4%. In terms of overall system performance (the decision tree's node propagating error taken into account), best classification accuracies were 89.5%, 79.6% and 82.7% for the recognition of normal, infectious and cancer cases, respectively. The proposed system might be used as a second opinion tool for assisting diagnosis of different prostate pathologies.

  10. Oncogenes E6-E7 de los Papilomavirus Humanos de alto riesgo detectados por PCR en Biopsias de pene incluidas en parafina

    Directory of Open Access Journals (Sweden)

    I Guerrero

    1999-01-01

    Full Text Available La alta prevalencia del papilomavirus humano (PVH, referida a nivel mundial, en lesiones genitales de ambos sexos, el rol del varón como reservorio pasivo del virus, y el incremento de la mortalidad por cáncer genital en la mujer en nuestro país, motiva la detección y correlación de los oncogenes de los PVH de alto riesgo con la neoplasia de pene. Informamos de diez casos de biopsias de carcinoma escamoso de pene, incluidos en parafina, los cuales fueron investigados para la presencia de los oncogenes E6-E7 de PVH de alto riesgo, utilizando cebadores tipo específico para los PVH -16 y 18, mediante la reacción en cadena de la polimerasa (PCR. El 40% de los casos mostró un producto de amplificación ADN E6-E7 de los PVH estudiados, correspondiendo el 75% de ellos a detección simple por PVH-18 y el 25% presentó detección mixta ADN E6 - E7 del PVH-16 y 18 simultáneamente. El producto de amplificación fue sometido a comprobación por análisis de restricción específico. La prevalencia obtenida de los oncogenes E6-E7 de los PVH de alto riesgo, usando un método tan sensible como la PCR, apoya el rol de estos virus en el proceso de carcinogénesis de la neoplasia de pene.

  11. Usefulness of jejunal biopsy in the study of intestinal malabsorption in the elderly Utilidad de la biopsia yeyunal en el estudio de la malabsorción intestinal en el anciano

    Directory of Open Access Journals (Sweden)

    B. Lobo

    2004-04-01

    clave en el estudio de la malabsorción intestinal es la biopsia yeyunal, cuya utilidad, eficacia o complicaciones, son poco conocidas en el grupo de población de edad avanzada. Objetivo: determinar la utilidad de la biopsia yeyunal con la cápsula de Watson en el anciano. Pacientes: pacientes de edad superior a los 65 años, remitidos para biopsia yeyunal desde 1996 a 2001 por sospecha de malabsorción intestinal. Resultados: se han incluido 47 pacientes. La biopsia obtuvo muestra útil para estudio histológico en 42 casos, obteniendo muestra en un segundo intento en 3 de los 5 fracasos iniciales. La histología demostró atrofia vellositaria parcial en 10 casos (22,2%, atrofia vellositaria completa en 5 (11,1%, linfocitosis intraepitelial en 5 (11,1%, y casos aislados de linfangiectasia intestinal, amiloidosis, yeyunitis inespecífica y enfermedad de Whipple. La histología fue normal en 19 casos (42%. El diagnóstico definitivo fue enfermedad celíaca en 14 pacientes, sobrecrecimiento bacteriano en 3, yeyunitis en 3, enfermedad de Whipple en 1, linfangiectasia en 1, gastritis atrófica en 3, amiloidosis en 1 (asociada a sobrecrecimiento bacteriano, y colitis isquémica en 1. La biopsia yeyunal fue esencial para el diagnóstico en 20 pacientes. No se registró perforación o hemorragia en ningún paciente. Conclusión: en el estudio de la malabsorción intestinal del anciano, la biopsia yeyunal es un método diagnóstico útil y seguro para identificar la causa de la malabsorción.

  12. A comparison of transrectal hyperthermia, transurethral thermotherapy, urolume wallstent, and prostatic spiral for benign prostatic hyperplasia patients at poor operative risk.

    Science.gov (United States)

    Montorsi, F; Guazzoni, G; Bergamaschi, F; Consonni, P; Galli, L; Rigatti, P

    1994-01-01

    Transrectal hyperthermia, transurethral thermotherapy, prostatic stent, and prostatic spiral were used to treat 120 poor operative risk patients with symptomatic benign prostatic hyperplasia. The preoperative subjective and objective conditions of the four groups (each of 30 patients) were comparable. None of the patients had an indwelling catheter, but according to flow nomograms, all were obstructed. The greatest increase in peak flow rate was observed after stent placement, while the greatest decrease of residual urine volume was seen after the insertion of the stent and transrectal hyperthermia. According to maximum flow nomograms, only the placement of the stent resolved bladder outlet obstruction. The greatest improvement in subjective symptoms was the result of stent insertion, but the heating procedures also caused a significant reduction of symptom scores. The spiral produced satisfactory results only in the short term.

  13. Manual transrectal palpations performed by veterinary students in cows: a Surrey - Palpaciones transrectales realizadas por estudiantes de veterinaria en las vacas: una encuesta

    Directory of Open Access Journals (Sweden)

    João Simões

    2012-03-01

    Full Text Available AbstractVeterinary education of novice veterinary students in bovine reproduction field, like rectum palpation training, represent some handicaps mainly related with animal welfare.ResumenLa educación veterinaria de estudiantes de veterinaria en el campo de la reproducción bovina, en el caso del entrenamiento mediante la palpación transrectal, tiene algunas desventajas, principalmente relacionadas con el bienestar animal.

  14. DETECCIÓN DE BACILOS ÁCIDO ALCOHOL RESISTENTES EN BIOPSIAS EMBEBIDAS EN PARAFINA EN CASOS DE INFLAMACIÓN GRANULOMATOSA CRÓNICA.

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2010-01-01

    Full Text Available La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspondientes a 30 pacientes (63,3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008. A cada muestra se le realizaron tres cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en pacientes con IGC necrotizante, reflejando una excelente concordancia en el diagnóstico (kappa=0,89, IC95%[0,68-1,0]. Sin embargo, la tinción con Auramina fue superior a la tinción Ziehl Neelsen para la detección de BAAR en pacientes con IGC no necrotizante (kappa=0,65, IC95%[0,23-1,0]. No se encontraron diferencias significativas entre la presencia de BAAR y el tipo de inflamacion, sexo y localización anatómica comprometida. En general, fue buena la concordancia entre los métodos histológicos empleados. Además, se hizo evidente la importancia de implementar el uso de técnicas moleculares mínimamente afectadas por el escaso número de bacilos presentes en las muestras, que finalmente ayudan en el reconocimiento del microorganismo.

  15. Usefulness of transrectal ultrasound-guided 12 core biopsy method in patients with clinically suspected prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Se Hwan; Lim, Joo Won; Park, Seong Jin; Ko, Young Tae; Kim, Yoon Wha [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    2000-06-15

    To evaluate the improvement of prostate cancer detection provided by transrectal ultrasound (TRUS)-guided 12 core biopsy method compared with sextant biopsy method. Between June 1997 and February 1999, 29 patients with pathologically proven prostate cancer in 124 patients who underwent TRUS-guided 12 core biopsy method were evaluated. They had abnormal findings in prostate specific antigen (PSA), digital rectal examination (DRE) or TRUS findings. The prostate was diffusely enlarged in all patients on DRE findings and in 15 cases (15/29, 52%), hard nodule was palpated. The average of PSA and prostate specific antigen density (PSAD) is 229.33 ng/ml (1-2280) and 9.14 ng/ml/cm{sup 3} (0.048-142.5), respectively, 12 transrectal biopsy, including 2 transition zones, was performed in both lobe, 6 biopsies were located in both base, middle and apex. Then 2 biopsies were inserted between 3 biopsies in both peripheral zone and 2 biopsies were performed in both transition zone. Each specimen was pathologically examined. The results of pathology were compared with method 1 and 2, respectively. We defined the method 1 and 2 as different sextant biopsy method. The method 1 is that cores are taken from both base, middle and apex and method 2 is that cores are taken from both base, apex and transition zone. TRUS findings were analyzed by two radiologists. Of the 29 patients with prostate cancer, 3 (10%) had carcinomas only in the additional regions as compared with method. When compared with method 2,2 (7.0%) had carcinomas only in the additional regions. 2 patients were same in both cases. TRUS findings were abnormal in 21 cases in all patients whose 12 biopsy method was not helpful. 12 biopsy method was helpful in 2/8 (25%) whose TRUS findings were non-specific and 1/21 (4.8%) whose TRUS findings were abnormal. Small low echoic lesion was seen in one patients whose 12 biopsy method was helpful, but cancer was found in other area. TRUS-guided 12 core biopsy method may be superior

  16. Biopsia de la arteria temporal: revisión de indicaciones y técnica quirúrgica para cirujanos plásticos Temporal artery biopsy: review of indications and surgical technique for plastic surgeons

    Directory of Open Access Journals (Sweden)

    A. Rodríguez Lorenzo

    2007-06-01

    Full Text Available La arteritis de células gigantes (ACG es una vasculitis que presenta complicaciones graves si no es diagnosticada y tratada precozmente con corticoides a altas dosis. La biopsia de la arteria temporal (BAT es la técnica diagnóstica estandarizada utilizada para confirmar la enfermedad. Se trata de una técnica sencilla y con poca morbilidad. No obstante, en la actualidad existe una controversia sobre su indicación en pacientes con sospecha clínica de arteritis sin síntomas craneales debido a la baja tasa de positividad de la biopsia. Presentamos en este trabajo una serie de 28 pacientes en los que se realizaron 30 BAT con el objetivo de revisar las indicaciones y describir la técnica quirúrgica utilizada.Giant cell arteritis is a vasculitis that presents serious complications if it is not diagnosed and treated prematurely with corticosteroids to high dose. The temporal artery biopsy is the gold estandar technique of diagnosis used to confirm the disease. It is a simple technique with little morbidity. Nevertheless, currently there is a controversy on its indication in patients with clinical suspicion of arteritis without craneal symptoms because of the downward rate of positiveness of the biopsy. We present in this work a serie of 28 patients in which 30 biopsies were carried out with the objective to review the indications and to describe the surgical technique utilized.

  17. Transrectal microwave thermotherapy causing a short-time influence on sperm quality in Chinese chronic nonbacterial prostatitis patients.

    Science.gov (United States)

    Jin, Jia-Xin; Wang, Han-Zhang; Zhai, Zheng-Xing; Ma, Bao-Liang; Li, Qin-Fang; Xiao, Nan; Wang, Zhi-Ping; Rodriguez, Ronald

    2016-08-19

    Chronic prostatitis can affect the sperm's quality. Previous studies have shown that transrectal microwave thermotherapy (TRMT) results in symptomatic relief in patients with chronic prostatitis, but the effects on sperm have not been carefully investigated. This study evaluates the impact of TRMT on the relief or decrease of symptoms and quality of sperm when used to treat patients with chronic nonbacterial prostatitis. Sixty patients were enrolled in the study. TRMT treatment was administered over 5 days, 1 h per day. Semen examination was carried out pretreatment and immediately at the conclusion of the 5-day treatment. Also, it was repeated 1 month, 3 months, and 6 months later. The treatment's symptom relief efficacy was evaluated using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). After the treatment, the overall NIH-CPSI scores were lower compared to those of pretreatment. In addition, the white blood cells and lecithin in expressed prostatic secretion were normal after the treatment. The sperm count was decreased by 23.8% 3 months after the treatment, sperm motility was reduced by 10.3% immediately after treatment, and sperm deformity was increased by 17.2%. The sperm volume and PH were not affected. However, the sperm quality recovered after treatment and the malformation rate was also lower at 6 months after treatment. TRMT is a favorable and safe treatment option for patients with nonbacterial chronic prostatitis. It could relieve the patient's symptoms and impact on sperm quality in the short-term.

  18. 3D non-rigid registration using surface and local salient features for transrectal ultrasound image-guided prostate biopsy

    Science.gov (United States)

    Yang, Xiaofeng; Akbari, Hamed; Halig, Luma; Fei, Baowei

    2011-03-01

    We present a 3D non-rigid registration algorithm for the potential use in combining PET/CT and transrectal ultrasound (TRUS) images for targeted prostate biopsy. Our registration is a hybrid approach that simultaneously optimizes the similarities from point-based registration and volume matching methods. The 3D registration is obtained by minimizing the distances of corresponding points at the surface and within the prostate and by maximizing the overlap ratio of the bladder neck on both images. The hybrid approach not only capture deformation at the prostate surface and internal landmarks but also the deformation at the bladder neck regions. The registration uses a soft assignment and deterministic annealing process. The correspondences are iteratively established in a fuzzy-to-deterministic approach. B-splines are used to generate a smooth non-rigid spatial transformation. In this study, we tested our registration with pre- and postbiopsy TRUS images of the same patients. Registration accuracy is evaluated using manual defined anatomic landmarks, i.e. calcification. The root-mean-squared (RMS) of the difference image between the reference and floating images was decreased by 62.6+/-9.1% after registration. The mean target registration error (TRE) was 0.88+/-0.16 mm, i.e. less than 3 voxels with a voxel size of 0.38×0.38×0.38 mm3 for all five patients. The experimental results demonstrate the robustness and accuracy of the 3D non-rigid registration algorithm.

  19. Sperm DNA fragmentation and morphological degeneration in chilled elephant (Elephas maximus and Loxodonta Africana) semen collected by transrectal massage.

    Science.gov (United States)

    O'Brien, J K; Steinman, K J; Montano, G A; Love, C C; Robeck, T R

    2013-05-01

    Ejaculates from nine Asian and two African elephants were analysed to gain a further understanding of mechanisms underlying variable semen quality after transrectal massage. Semen analysis was performed after collection (0 h; subjective motility parameters only) and after 24 h of chilled storage at 10 °C (24 h; all ejaculate and sperm characteristics). Ejaculates with ≤50% total motility (TM) at 24 h, which represented >90% of collection attempts, contained a sperm population with a high degree of DNA damage (64.2 ± 19.2% fragmented DNA) and an elevated incidence of detached heads (43.3 ± 22.5%). In contrast, good quality ejaculates designated as those with >50% TM at 24 h displayed higher (p < 0.05) values of sperm kinetic parameters, DNA integrity and normal morphology. Fertility potential was high for good quality ejaculates from two males (one Asian and one African bull) based on in vitro characteristics after chilled storage for up to 48 h post-collection. Urine contamination of semen, as assessed quantitatively by creatinine concentration, was confirmed as a significant factor in reduced elephant ejaculate quality. However, the identification of considerable DNA damage and morphological degeneration in the majority of ejaculates after only 24 h of chilled storage indicates that sperm ageing could be a primary contributor to inconsistent semen quality in the elephant.

  20. The Rectal Administration of Lignocaine Gel and Periprostatic Lignocaine Infiltration During Transrectal Ultrasound-Guided Prostate Biopsy Provides Effective Analgesia

    Science.gov (United States)

    Siddiqui, EJ; Ali, S; Koneru, S

    2006-01-01

    INTRODUCTION Transrectal ultrasound guided prostate needle biopsy (TRUS) is the standard procedure to diagnose or exclude prostate cancer. This procedure can be associated with significant discomfort, both on insertion of the ultrasound probe as well as on taking the biopsy. We evaluated a new technique for pain relief during TRUS biopsy. PATIENTS AND METHODS In Group 1 (n = 60), the biopsies were taken without any analgesia. In Group 2 (n = 60), 11 ml of Instillagel (2% lignocaine) was administered rectally prior to probe insertion and 5 ml of 1% lignocaine periprostatic injection was administered before taking the biopsy. The discomfort encountered during the procedure was graded by the patient on a scale ranging from no discomfort to mild, moderate and severe pain. RESULTS In Group 2, there was a marked reduction in the pain experienced during the procedure. The Chi-squared test for trend showed a significant association between the rectal administration of local anaesthetic gel and reduction in pain on probe insertion (P = 0.0001). There was also a significant association between the use of periprostatic lignocaine injection and reduction in pain on taking the biopsy (P < 0.0001). CONCLUSIONS The use of lignocaine gel prior to probe insertion and periprostatic infiltration of lignocaine before taking the needle biopsy significantly reduces the pain experienced by the patient during TRUS-guided prostate biopsy. PMID:16551424

  1. Hiperplasia estromal pseudoangiomatosa de la mama (PASH): presentación de dos casos Pseudoangiomatous stromal hyperplasia

    OpenAIRE

    Marta Machado; Alejandrina Garzón; Verónica Muñoz; Ma. Guadalupe Flores Turk

    2009-01-01

    La hiperplasia estromal pseudoangiomatosa (PASH) es una lesión mamaria benigna infrecuente, que afecta comúnmente a mujeres premenopáusicas y que se presenta como un nódulo único, móvil, de consistencia firme y por lo general unilateral. Hay un sobrecrecimiento benigno de tejido conectivo fibroso de la mama que produce numerosos espacios que semejan estructuras vasculares. En la actualidad, la alternativa diagnóstica la provee la punción biopsia percutánea eco-dirigida o por estereotaxia, la ...

  2. Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias Dinámica del virus de la hepatitis C con carga viral y ALT y monitoreo del daño hepático libre de biopsias

    Directory of Open Access Journals (Sweden)

    Justino Alavez Domínguez

    2006-12-01

    Full Text Available Se compara el modelo estándar reducido de tres poblaciones (hepatocitos sanos y enfermos, y carga viral para el estudio de la dinámica del virus de la hepatitis C (VHC, con el modelo de la dinámica viral con alanina aminotransferasa (ALT. En términos del parámetro umbral que es el mismo para ambos modelos, se determina la existencia y estabilidad del estado de equilibrio endémico, así como la estabilidad global del estado de equilibrio del individuo sano. Por otro lado, se presenta un estudio experimental que muestra que es posible monitorear el daño hepático sin biopsias, mediante la estimación numérica de los parámetros de los modelos, considerando solamente mediciones de la carga viral, de los niveles de ALT y una valoración razonable del daño hepático pretratamiento.aThe standard model of three populations (healthy and unhealthy hepatocytes, and viral load for the study of the dynamics of hepatitis C virus (HCV, is compared with viral dynamic model with alanine aminotransferase (ALT. In terms of the threshold parameter that it’s the same for both models, the existence and local asymptotic stability of the endemically infected equilibrium steady state, and the global stability of the healthy individual equilibrium steady state are established. Furthermore, an experimental study is presented showing that it’s possible to carry out the monitoring of hepatic damage biopsies free by numerical parameter estimation, considering only viral load and ALT levels measurements and a reasonable assessment of pretreatment hepatic damage.

  3. Classification of Focal Prostatic Lesions on Transrectal Ultrasound (TRUS) and the Accuracy of TRUS to Diagnose Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ho Yun [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lee, Hak Jong; Byun, Seok Soo; Lee, Sang Eun; Hong, Sung Kyu [Seoul National University Bundang Hospital, Seongnam (Korea, Republic of); Kim, Seung Hyup [Seoul National University Hospital, Seoul (Korea, Republic of)

    2009-06-15

    To improve the diagnostic efficacy of transrectal ultrasound (TRUS)-guided targeted prostatic biopsies, we have suggested the use of a new scoring system for the prediction of malignancies regarding the characteristics of focal suspicious lesions as depicted on TRUS. A total of 350 consecutive patients with or without prostate cancer who underwent targeted biopsies for 358 lesions were included in the study. The data obtained from participants were randomized into two groups; the training set (n = 240) and the test set (n = 118). The characteristics of focal suspicious lesions were evaluated for the training set and the correlation between TRUS findings and the presence of a malignancy was analyzed. Multiple logistic regression analysis was used to identify variables capable of predicting prostatic cancer. A scoring system that used a 5-point scale for better malignancy prediction was determined from the training set. Positive predictive values for malignancy prediction and the diagnostic accuracy of the scored components with the use of receiver operating characteristic curve analysis were evaluated by test set analyses. Subsequent multiple logistic regression analysis determined that shape, margin irregularity, and vascularity were factors significantly and independently associated with the presence of a malignancy. Based on the use of the scoring system for malignancy prediction derived from the significant TRUS findings and the interactions of characteristics, a positive predictive value of 80% was achieved for a score of 4 when applied to the test set. The area under the receiver operating characteristic curve (AUC) for the overall lesion score was 0.81. We have demonstrated that a scoring system for malignancy prediction developed for the characteristics of focal suspicious lesions as depicted on TRUS can help predict the outcome of TRUS-guided biopsies.

  4. Oral antibiotics in trans-rectal prostate biopsy and its efficacy to reduce infectious complications: Systematic review

    Directory of Open Access Journals (Sweden)

    Mohand Deeb Yaghi

    2015-01-01

    Full Text Available For the diagnosis of prostate cancer trans-rectal prostate biopsy (TRPB is used commonly, the procedure is associated with infective complications. There is evidence that antibiotics (ABx decrease infective events after TRPB, but different regimens are used. To systematically review different regimens of prophylactic oral ABx in TRPB. MEDLINE, EMBASE, clinical trials site, and Cochrane library were searched, experts were consulted for relevant studies. Randomized clinical trials conducted in the last 20 years, which investigated the different oral antibiotic regimens in TRPB, and compared their efficacy to reduce infectious complications were analyzed. Primary outcomes were bacteriuria, urinary tract infection (UTI, fever, bacteremia, and sepsis. Secondary outcomes were the hospitalization rate and the prevalence of ABx-resistant bacteria. Nine trials were eligible with 3012 patients. ABx prevented bacteriuria (3.5% vs. 9.88%, UTI (4.46% vs. 9.75%, and hospitalization (0.21% vs. 2.13% significantly in comparison with placebo or no treatment. No significant difference was found in all the outcomes of the review between the single dose regimen and the 3 days. The single dose regimen was as effective as the multiple doses except in bacteriuria (6.75% vs. 3.25%, and the prevalence of ABx-resistant bacteria (1.57% vs. 0.27%. Quinolones reduced only UTI significantly in comparison with other ABx (chloramphenicol, trimethoprim-sulfamethoxazol. It is essential to prescribe prophylactic ABx in TRPB. No conclusive evidence could be claimed about the superiority of the multiple or the 3 days regimens to the single dose regimen. Unexpectedly, ABx-resistant bacteria were identified more often in the single dose cohorts.

  5. Fully automatic prostate segmentation from transrectal ultrasound images based on radial bas-relief initialization and slice-based propagation.

    Science.gov (United States)

    Yu, Yanyan; Chen, Yimin; Chiu, Bernard

    2016-07-01

    Prostate segmentation from transrectal ultrasound (TRUS) images plays an important role in the diagnosis and treatment planning of prostate cancer. In this paper, a fully automatic slice-based segmentation method was developed to segment TRUS prostate images. The initial prostate contour was determined using a novel method based on the radial bas-relief (RBR) method, and a false edge removal algorithm proposed here in. 2D slice-based propagation was used in which the contour on each image slice was deformed using a level-set evolution model, which was driven by edge-based and region-based energy fields generated by dyadic wavelet transform. The optimized contour on an image slice propagated to the adjacent slice, and subsequently deformed using the level-set model. The propagation continued until all image slices were segmented. To determine the initial slice where the propagation began, the initial prostate contour was deformed individually on each transverse image. A method was developed to self-assess the accuracy of the deformed contour based on the average image intensity inside and outside of the contour. The transverse image on which highest accuracy was attained was chosen to be the initial slice for the propagation process. Evaluation was performed for 336 transverse images from 15 prostates that include images acquired at mid-gland, base and apex regions of the prostates. The average mean absolute difference (MAD) between algorithm and manual segmentations was 0.79±0.26mm, which is comparable to results produced by previously published semi-automatic segmentation methods. Statistical evaluation shows that accurate segmentation was not only obtained at the mid-gland, but also at the base and apex regions.

  6. Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier; Lyonnet, Denis [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Inserm, U556, Lyon (France); Girouin, Nicolas; Glas, Ludivine; Ben Cheikh, Alexandre [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Gelet, Albert [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Inserm, U556, Lyon (France); Mege-Lechevallier, Florence [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Pathology, Lyon (France); Rabilloud, Muriel [Hospices Civils de Lyon, Department of Biostatistics, Lyon (France); Universite de Lyon 1, UMR CNRS, Laboratoire Biostatistiques-Sante, Pierre-Benite (France); Chapelon, Jean-Yves [Inserm, U556, Lyon (France)

    2010-01-15

    The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies (''routine biopsies''); operator 2 obtained up to three cores per suspicious lesion on MRI (''targeted biopsies''). Seventy-seven suspicious lesions were detected on DCE images (n=52), T2w images (n=2) or both (n=23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p=0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p<0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05-3.64) and 1.38 (95% CI 1.13-1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue. (orig.)

  7. Association between Seminal Vesicle Invasion and Prostate Cancer Detection Location after Transrectal Systemic Biopsy among Men Who Underwent Radical Prostatectomy.

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    Young Ik Lee

    Full Text Available Our hypothesis is that the location of the seminal vesicles near the base of the prostate, the more positive cores are detected in the base, the greater the risk of seminal vesicle invasion. Therefore we investigate the clinical outcomes of base dominant prostate cancer (BDPC in transrectal ultrasound (TRUS -guided biopsies compared with anteromiddle dominant prostate cancer (AMPC.From November 2003 to June 2014, a total of 990 intermediate and high risk prostate cancer (PCa patients who underwent radical prostatectomy (RP were enrolled and stratified into two groups according to proportion of positive cores-BDPC group had ≥ 33.3% ratio of positive cores from the prostate base among all positive cores and AMPC group < 33.3% in systemic biopsy. Between two groups, we compared the rate of pathologic outcomes and biochemical recurrence (BCR. We performed multivariate logistic regression model to confirm the significance of BDPC to seminal vesicle invasion (SVI and Cox proportional hazard analysis to BCR.Among these 990 PCa patients, the 487 patients in BDPC group had more advanced clinical stage (p<0.001, a higher biopsy GS (p = 0.002, and a higher rate of extracapsular extension (ECE, SVI and BCR (all p<0.001 than AMPC group. The patients in BDPC group had poor BCR free survival rate via Kaplan-meier analysis (p<0.001. The ratio of the base positive cores was a significant predictor to SVI in multivariate analysis (p < 0.001 and significant predictor of BCR in multivariate Cox proportional analysis (hazard ratio: 1.466, p = 0.004.BDPC in TRUS-guided prostate biopsies was significantly associated with SVI and BCR after adjusting for other clinical factors. Therefore, BDPC should be considered to be a more aggressive tumor despite an otherwise similar cancer profile.

  8. Factors associated with the differential in actual gestational age and gestational age predicted from transrectal ultrasonography in pregnant dairy cows.

    Science.gov (United States)

    Fitzgerald, A M; Ryan, D P; Berry, D P

    2015-08-01

    The objective of the study was to determine (1) how gestational age predicted using transrectal ultrasonography related to actual gestational age derived as the number of days from the most recent artificial insemination date, (2) what factors, if any, were associated with the differential between the two measures, and (3) the association between this differential in gestational age and the likelihood of subsequent pregnancy loss, stillbirth, or calving dystocia. The data set contained 7340 ultrasound records from 6805 Holstein Friesian dairy cows in 175 herds. Ultrasonography assessment underestimated gestational age relative to days since last service by 0.51 days (standard error [SE]: 0.040), although the differential was less during embryonic development phase (i.e., ≤42 days of gestation; mean overestimation of 0.31 days) versus fetal development phase (i.e., >42 days of gestation; mean underestimation of 0.81 days). Predicted calving date calculated from ultrasonography was 1.41 days (SE: 0.040) later than the actual subsequent calving date and was, on average, 0.52 days later than predicted calving date, assuming a gestation length of 282 days. Parity of the dam (P gestation length. Gestation length was 1.27 days longer (SE: 0.01) for bull calves compared to heifer calves. Calves from beef sires had a longer gestation length than calves from dairy sires, and older parity cows had a longer gestation length than younger cows. The results highlight factors associated with differences in gestational age obtained from ultrasonography and insemination data and illustrate the value of ultrasonography for the prediction of calving date and pregnancy loss.

  9. Biopsy of the prostate guided by transrectal ultrasound: relation between warfarin use and incidence of bleeding complications

    Energy Technology Data Exchange (ETDEWEB)

    Ihezue, C.U. [Department of Radiology, Southampton General Hospital (United Kingdom); Smart, J. [Department of Radiology, Southampton General Hospital (United Kingdom); Dewbury, K.C. [Department of Radiology, Southampton General Hospital (United Kingdom)]. E-mail: keith.dewbury@suht.swest.nhs.uk; Mehta, R. [Department of Radiology, Southampton General Hospital (United Kingdom); Burgess, L. [Department of Radiology, Southampton General Hospital (United Kingdom)

    2005-04-01

    AIM: To determine the relation between warfarin use and the frequency of bleeding complications after biopsy of the prostate guided by transrectal ultrasound (TRUS). METHODS: Overall, 1022 consecutive patients with suspected prostatic disease were followed after biopsy. Warfarin and aspirin use was determined on the day of the procedure. A TRUS-guided biopsy was performed and patients were offered a questionnaire to complete 10 days after the procedure, to determine any immediate or delayed bleeding complications. Follow-up telephone calls were made to those who had not replied within the stipulated period. RESULTS: Of the 1000 patients who replied, 49 were receiving warfarin, 220 were receiving aspirin and 731 were not receiving any anticoagulant drugs. Of the 49 subjects reporting current use of warfarin, 18 (36.7%) experienced haematuria, compared with 440 (60.2%) of the patients receiving no anti-coagulant drugs who reported haematuria. This was statistically significant (p=0.001). Of the group receiving warfarin, 4 (8.2%) experienced haematospermia whereas 153 (21%) of the group receiving no anticoagulant medication reported haematospermia. This difference also was statistically significant (p=0.030). Rectal bleeding was experienced by 7 (14.3%) of the group receiving warfarin compared with 95 (13%) in the group without anticoagulant medication, but this was not statistically significant (p=0.80). We also demonstrated that there was no statistically significant association between the severity of the bleeding complications and medication with warfarin. CONCLUSION: None of the group receiving warfarin experienced clinically important bleeding complications. Our results suggest that the frequency and severity of bleeding complications were no worse in the warfarin group than in the control group and that discontinuing anticoagulation medication before prostate biopsy may be unnecessary.

  10. WE-A-17A-11: Implanted Brachytherapy Seed Movement Due to Transrectal Ultrasound Probe-Induced Prostate Deformation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, D; Usmani, N; Sloboda, R [Cross Cancer Institute, Edmonton, Alberta (Canada); University of Alberta, Edmonton, Alberta (Canada); Meyer, T; Husain, S; Angyalfi, S [Tom Baker Cancer Centre, Calgary, Alberta (Canada); University of Calgary, Calgary, Alberta (Canada); Kay, I [Canterbury District Health Board, Christchurch (New Zealand)

    2014-06-15

    Purpose: To characterize the movement of implanted brachytherapy seeds due to transrectal ultrasound probe-induced prostate deformation and to estimate the effects on prostate dosimetry. Methods: Implanted probe-in and probe-removed seed distributions were reconstructed for 10 patients using C-arm fluoroscopy imaging. The prostate was delineated on ultrasound and registered to the fluoroscopy seeds using a visible subset of seeds and residual needle tracks. A linear tensor and shearing model correlated the seed movement with position. The seed movement model was used to infer the underlying prostate deformation and to simulate the prostate contour without probe compression. Changes in prostate and surrogate urethra dosimetry were calculated. Results: Seed movement patterns reflecting elastic decompression, lateral shearing, and rectal bending were observed. Elastic decompression was characterized by anterior-posterior expansion and superior-inferior and lateral contractions. For lateral shearing, anterior movement up to 6 mm was observed for extraprostatic seeds in the lateral peripheral region. The average intra-prostatic seed movement was 1.3 mm, and the residual after linear modeling was 0.6 mm. Prostate D90 increased by 4 Gy on average (8 Gy max) and was correlated with elastic decompression. For selected patients, lateral shearing resulted in differential change in D90 of 7 Gy between anterior and posterior quadrants, and increase in whole prostate D90 of 4 Gy. Urethra D10 increased by 4 Gy. Conclusion: Seed movement upon probe removal was characterized. The proposed model captured the linear correlation between seed movement and position. Whole prostate dose coverage increased slightly, due to the small but systematic seed movement associated with elastic decompression. Lateral shearing movement increased dose coverage in the anterior-lateral region, at the expense of the posterior-lateral region. The effect on whole prostate D90 was smaller due to the subset

  11. Incidence of sepsis following transrectal ultrasound guided prostate biopsy at a tertiary-care medical center in Lebanon

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    Mohammed Shahait

    2016-02-01

    Full Text Available ABSTRACT Background Urosepsis is a rare but life-threatening complication following transrectal ultrasound (TRUS guided needle prostate biopsy. Despite the technological and pharmacological improvements, the problem of bacterial urosepsis after prostate biopsy remains. A strategy for preventing urosepsis following TRUS prostate biopsy in areas with high prevalence of resistant strains or patients presenting risk factors is lacking. Objectives The aim of this study was to assess the prevalence of urosepsis, as well its predictors, following TRUS guided needle biopsy of the prostate in a tertiary care medical center in Lebanon. Materials and Methods We carried out a retrospective study on all patients who underwent TRUS prostate biopsy at the American University of Beirut Medical Center between January 1, 2011 and June 31, 2013. Patients’ hospital charts were reviewed. Data collected included demographic information, pre-procedure disease specific information, as well as post-procedure information. Predictors of urosepsis following TRUS were assessed. Results In total, 265 patients were included in this study, where the prevalence of urosepsis following TRUS prostate biopsy was found to be 9.4%. The significant independent predictors of urosepsis were found to be: age with an OR=0.93 (95% CI: 0.88–1.00, p-value=0.03, and hypertension comorbidity with an OR=3.25 (95% CI: 1.19–8.85, p-value=0.02. Conclusion We found a high prevalence of urosepsis among patients who have undergone TRUS prostate biopsy, and identified two significant risk factors. The results of this study highlight the importance of implementing strategies for prevention of urosepsis following TRUS prostate biopsy.

  12. Application of transrectal ultrasonography in the diagnosis of gynecologic disease%经直肠超声在妇科疾病诊断中的应用

    Institute of Scientific and Technical Information of China (English)

    陶珍; 魏玲玲; 张红安

    2013-01-01

    Objective To discuss the using value of transrectal ultrasonography in the diagnosis of patients with gynecologic disease and nonsexual history. Methods The uterine, ovarian and pelvic of 83 patients were observed by transrectal and abdomen ultrasonography. Results The positive rate of detection results was 78.3%,in which the change of polycystic ovary accounting for 53% of the total cases. Conclusion The detection method and result of transrectal ultrasonography is basically same as transvaginal scan for female patients with nonsexual history;transrectal combined with abdomen ultrasonography can raise the accurately diagnostic rate and provide powerful imaging diagnostic basis for clinical diagnosis through combining with clinical detection results,especially for the diagnosis of polycystic ovarian syndrome.%  目的探讨经直肠超声在无性生活史等患者妇科疾病诊断中的应用价值。方法本组83例患者,采用经直肠超声,结合腹部超声补充检查,观察子宫、卵巢及盆腔情况。结果检出阳性率为78.3%,其中卵巢多囊改变占病例总数的53%。结论对于无性生活史等女性患者,经直肠超声的检查方法及结果,基本等同于经阴道超声检查;把直肠超声和腹部超声结合应用,以提高诊断率,结合临床检验结果,为临床医生的临床诊断,特别是对多囊卵巢综合征的诊断提供了有力的影像诊断依据。

  13. Treatment of anastomotic leakage after rectal resection with transrectal vacuum-assisted drainage (VAC). A method for rapid control of pelvic sepsis and healing

    DEFF Research Database (Denmark)

    Nagell, Carl Frederik Otto; Holte, Kathrine

    2006-01-01

    OBJECTIVE: Anastomotic leakage after rectal resection is associated with high morbidity and mortality. Patients without peritonitis can be treated conservatively by transrectal rinsing and drainage. However, healing is often very slow, and formation of abundant scar tissue resulting in a poor...... functional result is not uncommon. Vacuum-assisted closure (VAC) has been shown to accelerate wound healing by increasing local blood flow, reducing bacterial load and stimulating growth of granulation tissue. In this paper, we describe VAC as a method for treating anastomotic leakage after rectal resection...

  14. Multi-drug resistant E.coli urosepsis in physicians following transrectal ultrasound guided prostate biopsies--three cases including one death.

    Science.gov (United States)

    Carlson, William H; Bell, David G; Lawen, Joseph G; Rendon, Ricardo A

    2010-04-01

    Three male physicians underwent transrectal ultrasound guided prostate biopsies for elevated prostate-specific antigen levels or irregular digital rectal exam findings. All three of these patients developed urosepsis secondary to multi-drug resistant organisms despite antibiotic prophylaxis. There are increasing reports of infectious complications following prostate biopsy caused by multi-drug resistant organisms. These cases highlight the potentially lethal risks to healthcare workers who are more likely to harbor multi-drug resistant organisms than the general population. Further research into preoperative assessment and appropriate antibiotic prophylaxis in all potentially high risk patients is warranted.

  15. Abdominal masses in the pediatric age. Characterization by CT guided fine needle aspiration biopsy; Masse addominali nell'eta' pediatrica. Caratterizzazione mediante biopsia computerizzata con ago sottile guidata con Tomografia Computerizzata

    Energy Technology Data Exchange (ETDEWEB)

    Marano, I.; Soscia, E.; Salvatore, M. [Naples Univ. Federico 2. (Italy). Dipt. di Scienze Biomorfologiche e Fuzionali, Cattedra di Radiologia

    1999-04-01

    CT-guided fine needle aspiration biopsy (FNAB) is known to improve diagnosis of expansive abdominal lesions, especially relative to more invasive procedure like explorative laparotomy. FNAB in not commonly use in pediatric patients because of their poor collaboration and of associated risks. The authors investigated the feasibility of FNAB in the pediatric age. [Italian] Sono noti i vantaggi che la biopsia percutanea con ago sottile guidato con TC puo' apportare per la diagnosi delle lesioni espansive addominali, soprattutto se confrontata con procedure piu' invasive come la laparatomia esplorativa. Questo tipo di metodica e' attalmente poco utilizzato nel caso di pazienti pediatrici a causa della scarsa collaborazione e dei rischi associati. Gli autori valutano l'applicabilita' di tale procedura nell'eta' pediatrica alla luce delle propria esperienza.

  16. Evaluacion de la biopsia transpedicular guiada por TAC Avaliação da biópsia transpedicular guiada por TC Evaluation of transpedicular percutaneous biopsy guided by CT

    Directory of Open Access Journals (Sweden)

    Luis Miguel Rosales Olivarez

    2012-09-01

    Full Text Available OBJETIVO: Valorar la utilidad de la biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada en conjunto con la sistematización de estudios como pruebas diagnósticas de la etiología de la destrucción vertebral. MÉTODOS: Estudio de serie de casos prospectivo transversal de 21 pacientes a los que se les realizó biopsia transpedicular percutánea guiada por Tomografía Axial Computarizada y estudios de laboratorio y gabinete de marzo a julio del 2011, para evaluar su utilidad en el diagnóstico de destrucción vertebral. RESULTADOS: Fueron 21 pacientes, 14 hombres y 7 mujeres, con edad media de 59,2 años, cuyos niveles más afectados estuvieron en L1, L2 y L3. El reporte de la biopsia tuvo una precisión diagnóstica del 90,4%. En 2 casos se realizó correlación clínica entre biopsia y sistematización de estudios para obtener el diagnóstico. CONCLUSIÓN: La biopsia guiada por Tomografía Axial Computarizada es una técnica sencilla, útil, de bajo costo y eficaz en el estudio de la destrucción vertebral; la sistematización de estudios permite corroborar el diagnóstico de la biopsia.OBJETIVO: Avaliar a utilidade da biópsia transpedicular percutânea guiada por tomografia axial computadorizada em conjunto com a sistematização de estudos, como exames diagnósticos da etiologia da destruição vertebral. MÉTODOS: Estudo de série de casos, prospectivo e transversal de 21 pacientes submetidos à biópsia transpedicular percutânea guiada por tomografia axial computadorizada e exames laboratoriais e radiológicos, de março a julho de 2011, para avaliar sua utilidade no diagnóstico de destruição vertebral. RESULTADOS: Foram analisados 21 pacientes, 14 homens e 7 mulheres, com média de idade de 59,2 anos, cujos níveis mais afetados foram L1, L2 e L3. O laudo da biópsia teve precisão diagnóstica de 90,4%. Em dois casos, realizou-se a correlação clínica entre biópsia e sistematização de exames para obter

  17. Prolonged antibiotic therapy increases risk of infection after transrectal prostate biopsy: A case report after pancreasectomy and review of the literature

    Directory of Open Access Journals (Sweden)

    Guevar Maselli

    2014-12-01

    Full Text Available Infection due to prostate biopsy afflicted more than 5% of patients and is the most common reason for hospitalization. A large series from US SEER-Medicare reported that men undergoing biopsy were 2.26 times more likely to be hospitalized for infectious complications within 30 days compared with randomly selected controls. The factors predicting a higher susceptibility to infection remain largely unknown but some authors have higlighted in the etiopathogenesis the importance of the augmented prevalence of ciprofloxacin resistant variant of bacteria in the rectum flora. We present one case of sepsis after transrectal prostate biopsy in a patient with history of pancreatic surgery. Based on our experience patients candidated to prostate biopsy with transrectal technique with history of recent major surgery represent an high risk category for infective complication. Also major pancreatic surgery should be consider an high risk category for infection. A transperineal approach and preventive measures (such as rectal swab should be adopted to reduce biopsy driven infection.

  18. Local anesthesia for pain control during transrectal ultrasound-guided prostate biopsy: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Yan P

    2016-10-01

    Full Text Available Pu Yan,* Xiao-yan Wang,* Wei Huang, Yong Zhang Beijing Tian Tan Hospital, Capital Medical University, Neurology Research Division, China National Clinical Research Center for Neurological Disease, Beijing, People’s Republic of China *These authors contributed equally to this work. Background: A meta-analysis was performed to evaluate the efficacy and safety of intrarectal local anesthestic (IRLA, periprostatic nerve block (PPNB, and the combined modalities in alleviating the pain during transrectal ultrasound (TRUS-guided prostate biopsy.Materials and methods: A literature review was performed to identify all published randomized controlled trials (RCTs about IRLA vs no anesthesia or placebo gel; PPNB vs no injection, periprostatic placebo injection, or IRLA; combined PPNB and IRLA vs PPNB alone; and combined PPNB and intraprostatic nerve block (IPNB vs PPNB alone before TRUS-guided biopsy. Sources included MEDILINE, EMBASE, and Cochrane Library from 1980 to 2016. The main outcomes were biopsy pain score, probe manipulation pain score, and anesthetic infiltration pain score assessed by the visual pain scale.Results: A total of 26 articles involving 36 RCTs were used in this analysis: Although IRLA can lead to pain reduction, the result was not statistically significant when compared with no anesthesia or placebo gel (weighted mean difference [WMD]: -0.22, 95% CI: -0.45 to 0, P=0.06. PPNB can lead to significantly lower biopsy pain scores when compared with no analgesia (WMD: -1.32, 95% CI: -1.68 to -0.95, P<0.00001, placebo injection (WMD: -2.62, 95% CI: -3.16 to -2.07, P<0.00001, or IRLA (WMD: -1.31, 95% CI: -1.40 to -1.22, P<0.00001. PPNB + IRLA can lead to significantly lower biopsy pain scores when compared with PPNB alone (WMD: -0.45, 95% CI: -0.62 to -0.28, P<0.00001. PPNB + IPNB can lead to significantly lower biopsy pain scores when compared with PPNB alone (WMD: -0.73, 95% CI: -0.92 to -0.55, P<0.00001. There were no severe

  19. Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use.

    Science.gov (United States)

    Patel, Uday; Dasgupta, Prokar; Amoroso, Peter; Challacombe, Ben; Pilcher, James; Kirby, Roger

    2012-06-01

    Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Septicaemia is the most frequent cause of hospitalization after transtrectal prostate biopsy; fatalities have been reported and the incidence is on the rise. This study shows that men with a history of recent international travel or antibiotic use have up to four times increased risk of septicaemia and hospitalization. When they do occur, infections are usually due to multi-resistant E coli and additional care, e.g. delay before biopsy, different antibiotic prophylaxis or transperineal biopsy, should be considered in these cases. OBJECTIVE • To study the infection rate after prostate biopsy in those who have travelled overseas or used antibiotics in the 4 weeks before biopsy. PATIENTS AND METHODS • A total of 316 men with a mean (range) age of 61 (45-85) years were studied. All had undergone transrectal ultrasonography (TRUS)-guided prostate biopsy after standard antibiotic prophylaxis. • Before their biopsy the patients were risk stratified and a history of recent international travel or antibiotic use was recorded. • Those who suffered sufficiently severe infection/sepsis so as to require hospitalization were identified at the end of the study period. • The characteristics of these patients and the types of infections were explored and the relative risk (RR) of infection after recent travel or antibiotic use was calculated. RESULTS • Of the 316 men, 16 were hospitalized with infection. • The group with (n= 16) and without (n= 300) infection were equivalent in age, prostate-specific antigen level, disease status and number of biopsy cores taken. • Either recent travel or antibiotic use were independent risk factors for infection [travel: 8/16 vs 76/300; P= 0.04; RR 2.7 and antibiotic use: 4/16 vs 20/300; P= 0.025; RR 4]. There was no significant pattern in the countries visited or the type of antibiotic used. • Culture results were

  20. The criteria for the decision of transrectal US-guided prostate biopsy: Can we reduce the number of unnecessary biopsies?

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Joon Hyung; Cho, Jae Ho; Ahn, Jay Hong; Chang, Jay Chun [Yeungnam University College of Medicine, Taegu (Korea, Republic of)

    2001-09-15

    To establish the criteria which can safely reduce the number of unnecessary biopsies by comparing the transrectal ultrasonography (TRUS) findings, serum prostate-specific antigen (PSA), and prostate specific antigen density (PSAD) in the decision of criteria for the prostatic biopsy using TRUS. Two hundred and twenty patients underwent TRUS- guided prostate biopsy due to elevated PSA and/or focal nodule on TRUS were included. Sixty five (27.5%) patients were confirmed as prostate cancer, and remained 155 (70.5%) patients were reported as benign diseases including benign prostate hyperplasia. The sensitivity, specificity and accuracy of TRUS, PSA and PSAD were evaluated and the single criterion or the combination of the criteria which can safely reduce the unnecessary biopsies without missing prostatic cancer were investigated. The sensitivity, specificity and accuracy of TRUS, PSA (cut-off value, 4 ng/ml) and PSAD (cut-off level, 0.2 ng/ml/cm{sup 3}) were 78.5%/95.4%/95.4%/27.8%/51.6%/64/5%, 42.7%/64.5%/73.6%, respectively. PSAD cut-off level 0.2 ng/ml/cm{sup 3} was the most excellent single criterion for the decision of prostatic biopsy and the number of unnecessary biopsies was 100 cases. But 3 cases of prostatic cancer which the PSAD level was below 0.2 ng/ml/cm{sup 3} were included and in all these 3 cases, a focal nodule was detected on TRUS. Therefore, we applied these two criteria at once and the biopsies of 30 cases (13.6%) are unnecessary. With the single criterion, we could not obtain the satisfactory results but by the combinations of criteria (TRUS and PSAD), 30 (13.6%) cases are unnecessary biopsies without missing cancer. We think that the short term follow-up may be a substitute for the immediate when nodular lesion is suspicious on TRUS and serum PSAD level is below 0.2 ng/ml/cm{sup 3}.

  1. La biopsia estereotáctica en el diagnóstico de las lesiones cerebrales focales en sida Stereotactic brain biopsy in the diagnosis of focal brain lesions in AIDS

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    Marcelo Corti

    2008-08-01

    Full Text Available Las lesiones cerebrales focales constituyen una complicación frecuente en los pacientes con infección por el virus de la inmunodeficiencia humana (HIV y síndrome de inmunodeficiencia adquirida (sida. Durante el período comprendido entre enero de 1999 y mayo de 2007 se realizaron un total de 83 biopsias en pacientes con sida y lesiones cerebrales. Se incluyeron aquellos pacientes que no hubiesen respondido al algoritmo habitual de enfoque diagnóstico-terapéutico de estas lesiones. Todas las muestras obtenidas fueron sometidas a evaluación intraoperatoria para asegurar la obtención de material patológico y posterior análisis histopatológico y exámenes microbiológicos. De los 41 pacientes con lesiones cerebrales múltiples, 62 tenían localización supratentorial, en 4 eran infratentoriales y 17 mostraron ambas localizaciones. Cincuenta y un lesiones seleccionadas como blanco estereotáctico tuvieron refuerzo periférico del contraste. Se obtuvo material histopatológico en el 100% de los procedimientos. El diagnóstico más frecuente fue el de leucoencefalopatía multifocal progresiva (LEMP con 24 casos (29%, seguido del linfoma primario del sistema nervioso central (LPSNC con 19 diagnósticos (23% y de toxoplasmosis en 13 pacientes (15.7%. Se comprobó una relación significativa entre los diagnósticos histopatológicos y la localización de las lesiones y entre los diagnósticos histopatológicos y el comportamiento de las imágenes luego de la administración de la sustancia de contraste. El rédito diagnóstico alcanzó el 90.3% (75 biopsias. La morbiletalidad en esta serie fue de 2.4%. La biopsia cerebral estereotáctica permitió alcanzar el diagnóstico etiológico y adecuar el enfoque terapéutico en la mayoría de los pacientes de esta serie.Focal brain lesions are frequent complications among HIV/AIDS patients. Between January 1999 and May 2007, 83 procedures of stereotactic brain biopsies in HIV/AIDS patients with focal

  2. Morbidade da biópsia da próstata transretal guiada por ultrassonografia Morbidity of transrectal ultrasound guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Raphael Sandes Solha

    2013-04-01

    Full Text Available OBJETIVO: Avaliar a incidência de complicações pós-procedimento nos pacientes submetidos a biópsia prostática transretal guiada por ultrassom no setor de intervenção do Departamento de Diagnóstico por Imagem da Escola Paulista de Medicina - Universidade Federal de São Paulo. MATERIAIS E MÉTODOS: Foram avaliados, via contato telefônico, 132 pacientes submetidos a biópsia de próstata transretal guiada por ultrassom no período de abril/2011 a junho/2011, seguindo o protocolo padrão do nosso setor. RESULTADOS: As complicações pós-biópsia foram categorizadas em maiores e menores de acordo com a necessidade de avaliação médica adicional. Cinquenta e nove pacientes (61,8% apresentaram complicações, e desses, grande parte (86,4% apresentou sintomas leves e autolimitados, considerados menores. Oito pacientes (8,2% apresentaram complicações maiores, sendo que apenas um deles necessitou de tratamento sob regime de internação hospitalar. A retenção urinária foi a complicação maior mais incidente no nosso estudo. CONCLUSÃO: Corroborando outros estudos da literatura, nosso trabalho demonstrou baixa prevalência de complicações maiores após a biópsia prostática transretal.OBJECTIVE: To evaluate the incidence of postprocedural complications in patients submitted to transrectal ultrasound-guided prostate biopsy at the Unit of Intervention, Department of Imaging Diagnosis of Escola Paulista de Medicina - Universidade Federal de São Paulo. MATERIALS AND METHODS: Telephone interviews were conducted with 132 patients who had undergone transrectal ultrasound-guided prostate biopsy in the period from April 2011 to June 2011, according to the institution's protocol. RESULTS: Post-biopsy complications were categorized into two groups - minor and major complications, according to their need for further clinical evaluation. Complications were reported by 59 patients (61.8%, most of them (86.4% with mild and self-limited symptoms

  3. EVALUACIÓN DE DOS MÉTODOS DE EXTRACCIÓN DE ADN A PARTIR DE BIOPSIAS FIJADAS EN FORMALINA Y EMBEBIDAS EN PARAFINA EN CONDICIONES NO ÓPTIMAS

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2011-01-01

    Full Text Available Los tejidos de archivo son material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de mé- todos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no óptimas, se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,6% hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología, Hospital Universitario del Valle entre 2002 y 2007. Se realizaron 10 cortes a cada muestra y se sometieron a dos métodos de extracción de ADN: 1. convencional y 2. QIAamp-DNA mini kit ® . La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65,52 ng/μL ±11,47 (promedio ± EE y la relación 260/280 varió entre 0,52 y 2,30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60,89 ng/μL ± 6,02, con una absorbancia que osciló entre 0 y 2,64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificaron exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.

  4. Evaluación de dos métodos de extracción de ADN a partir de biopsias fijadas en formalina y embebidas en parafina en condiciones no optimas

    Directory of Open Access Journals (Sweden)

    Bravo Luis Eduardo

    2011-08-01

    Full Text Available Los tejidos de archivo son un material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de m��todos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no optimas. Se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,66%hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología del Hospital Universitario del Valle entre 2002-2007. A cada muestra se le realizaron 10 cortes y se sometieron a dos métodos de extracción de ADN: 1.Convencional y 2.QIAamp-DNA mini kit®. La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65.52ng/µl ±11.47 (promedio±EE y la relación 260/280 vario entre 0.52 y 2.30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60.89ng/µl±6.02, con una absorbancia que oscilo entre 0 y 2.64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificarón exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.

  5. Transjugular liver biopsy: histological diagnosis success comparing the trucut to the modified aspiration Ross needle Biopsia hepática transjugular: comparação do sucesso diagnóstico histológico entre as agulhas trucut e a aspirativa modificada de Ross

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Maciel

    2003-06-01

    Full Text Available BACKGROUND: Transjugular liver biopsy is an alternative procedure for patients who present contraindications to standard percutaneous procedure. AIM: To compare the rate of histological diagnosis obtained on transjugular liver biopsy with an automated trucut needle and with a modified Ross needle. PATIENTS / METHOD: Eighty-five patients with suspicion of chronic liver diseases and presenting contraindications for percutaneous liver biopsy (coagulopathy, massive ascites, morbid obesity, or chronic renal problems were submitted to 89 transjugular liver biopsies between March 1994 and April 2001 at ''Hospital São José, Irmandade da Santa Casa de Misercórdia'', Porto Alegre, RS, Brazil. Thirty-five patients underwent 36 biopsies with an automated trucut needle, and 50 patients underwent 53 biopsies with a modified Ross needle. RESULTS: Histological diagnosis was reached in 32/35 subjects submitted to transjugular liver biopsy with the trucut needle (91% and in 35/50 (70% submitted to biopsy with the modified Ross needle. Specimens obtained with the trucut needle were significantly larger and less fragmented than those obtained with the Ross needle. CONCLUSION: Transjugular liver biopsy with the automated trucut needle allowed a higher rate of histological diagnosis when compared to the modified Ross needle in patients with suspicion of chronic liver diseases.RACIONAL: A biopsia hepática transjugular é um procedimento alternativo para pacientes que apresentam contra-indicações ao procedimento padrão (percutâneo. OBJETIVO: Comparar o índice de diagnóstico obtido por meio da biopsia hepática transjugular utilizando uma agulha automatizada trucut e uma agulha Ross modificada. MÉTODOS: Oitenta e cinco pacientes com suspeita de doenças hepáticas crônicas e apresentando contra-indicações para biopsia hepática percutânea (coagulopatia, ascite maciça, obesidade mórbida ou problemas renais crônicos foram submetidos a 89 biopsias hep

  6. 经直肠腔内超声诊断后尿道结石的临床价值%The Clinical Value of Transrectal Ultrasonography in Diagnosing Hind Urethra Calculus

    Institute of Scientific and Technical Information of China (English)

    李庆; 谢江凌

    2013-01-01

    目的 探讨经直肠腔内超声对后尿道结石的诊断价值.方法 对36例后尿道结石患者采用经直肠腔内超声检查,并将超声诊断结果与临床结果进行对比分析.结果 经直肠腔内超声检查诊断后尿道结石35例,误诊1例.后尿道结石中,位于后尿道前列腺部22例,后尿道膜部14例,经直肠腔内超声检查诊断后尿道结石符合率为97.22%.结论 经直肠腔内超声检查对后尿道结石的诊断率高,可为临床治疗提供可靠的依据,值得临床推广应用.%Objective To study the value of transrectal ultrasonography in diagnosing hind urethra calculus. Methods Using intracavity probe, combined with high frequency rectum transducer and line transducer necessary, to check the hind urethra calculus by transrectal ultrasonography. Results By transrectal ultrasonography, 35 cases have been diagnosed as hind urethra calculus, misdiagnosis 1 case, 22 as prostate calculus of hind urethra and 14 as membrane calculus of hind urethra,the coincidence rate is 97. 22%. Conclusion Transrectal ultrasonography can improve the diagnostic rate of hind urethra calculus, provide reliable basis for the clinical diagnosis and treatment, worthy of clinical application.

  7. Impact of preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria on the incidence of sepsis following transrectal ultrasound guided prostate biopsy

    Science.gov (United States)

    Farrell, John J; Hicks, Jennifer L; Wallace, Stephanie E; Seftel, Allen D

    2017-01-01

    With the universal adoption of antibiotic prophylaxis prior to prostate biopsy, the current risk of post-biopsy infection (including sepsis) is study of preoperative rectal cultures to screen for rectal colonization with fluoroquinolone-resistant bacteria using ciprofloxacin-supplemented MacConkey agar culture media. To evaluate the feasibility and practicality of this test, one provider used the results of rectal swab cultures collected during the preoperative outpatient evaluation to adjust each patient’s preoperative antibiotic prophylaxis when fluoroquinolone-resistant enteric bacteria were detected, whereas two other providers continued usual preoperative care and empiric antimicrobial prophylaxis. Rectal colonization with fluoroquinolone-resistant bacteria was detected in 19/152 (12.5%) of patients. In our intention-to-treat analysis (N=268), the rate of post-biopsy sepsis was 3.6% lower in the group that was screened for rectal colonization with fluoroquinolone-resistant bacteria prior to transrectal prostate biopsy. The observed risk reduction in the rectal screening group trended toward, but did not achieve, statistical significance. We suggest that preoperative screening for rectal colonization with fluoroquinolone-resistant enteric bacteria may be a useful step toward mitigating post-prostate biopsy sepsis. PMID:28280717

  8. Prostate cancer detection upon transrectal ultrasound-guided biopsy in relation to digital rectal examination and prostate-specific antigen level: what to expect in the Chinese population?

    Directory of Open Access Journals (Sweden)

    Jeremy YC Teoh

    2015-01-01

    Full Text Available We investigated the prostate cancer detection rates upon transrectal ultrasound (TRUS-guided biopsy in relation to digital rectal examination (DRE and prostate-specific antigen (PSA, and risk factors of prostate cancer detection in the Chinese population. Data from all consecutive Chinese men who underwent first TRUS-guided prostate biopsy from year 2000 to 2013 was retrieved from our database. The prostate cancer detection rates with reference to DRE finding and PSA level of 50 ng ml−1 were investigated. Multivariate logistic regression analyses were performed to investigate for potential risk factors of prostate cancer detection. A total of 2606 Chinese men were included. In patients with normal DRE, the cancer detection rates were 8.6%, 13.4%, 21.8%, 41.7% and 85.2% in patients with PSA 50 ng ml−1 respectively. In patients with abnormal DRE, the cancer detection rates were 12.4%, 30.2%, 52.7%, 80.6% and 96.4% in patients with PSA 50 ng ml−1 respectively. Older age, smaller prostate volume, larger number of biopsy cores, presence of abnormal DRE finding and higher PSA level were associated with increased risk of prostate cancer detection upon multivariate logistic regression analyses (P < 0.001. Chinese men appeared to have lower prostate cancer detection rates when compared to the Western population. Taking the different risk factors into account, an individualized approach to the decision of TRUS-guided biopsy can be adopted.

  9. Application of transrectal ultrasound-guided repeat needle biopsy in the diagnosis of prostate cancer in Chinese population: A retrospective study

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    Yi Wang

    2016-01-01

    Full Text Available Background: Transrectal ultrasound-guided repeat needle biopsy (TUGRNB is widely used for diagnosis of prostate cancer (PCa. However, significance of TUGRNB in Chinese population was rarely reported. A retrospective study was conducted to evaluate the significance of TUGRNB applied in prediction of PCa in Chinese population. Materials and Methods: A total of 960 from January 2009 to December 2012 were included. Repeat needle biopsy rate and PCa positive detection rate were evaluated. Relationship between prostate specific antigen (PSA levels and PCa positive rates was analyzed. Results: PCa positive detection rate after initial needle biopsy was 28.4%, which was lower than the rate of repeat needle biopsy (40%. The rate for immediate transurethral resection (TUR, surgery after initial needle biopsy, was 27.1%, however with a low PCa positive detection rate (0.66%. The repeat needle biopsy rate was lower compared with the initial biopsy rate (P 20 ng/ml, PCa positive rate was significantly higher than those with PSA < 20 ng/ml (P < 0.05. Conclusion: PCa positive detection rate following repeat needle biopsy in Chinese population was higher, although the repeated needle biopsy rate was still in a low level. TUGRNB should attract more attention in the diagnosis of PCa.

  10. Amiloidosis Secundaria o Sistemática: Diagnóstico por la Biopsia Oral y por Patología Clínica en Relación con Pacientes Portadores de Enfermedades Crónicas en Especial TBC Crónica

    OpenAIRE

    Gutierrez Manay, Juan J.; Uriarte Mora, Carlos; Cuadrao Zavaleta, Luis; Rodriguez Alfaro, Miguel; Romero Rivas, Roberto; Gutierrez Portocarrero, Ledda Candy

    2014-01-01

    Tiene caracteres investigatorios ver el depósito anormal de sustancial amiloide en la mucosa oral, mediante la biopsia inocua de las áreas lateral gingival y dérmica (psoriatica) en 20 casos patológicos de pacientes enfermedad inflamatoria crónica, de larga evolución. Así como la aplicación de una adecuada historia clínica implementada en todos los pacientes en los diferentes hospitales y centros asistenciales donde practicando las incisiones operatorias, donde comunicamos y solicitamos el ad...

  11. Caracterización de los tumores testiculares de células germinales según biopsias del servicio de patología. Hospital México, Costa Rica: enero 2003 a marzo 2011

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    Julia Freer-Vargas

    2013-03-01

    Full Text Available Justificación y objetivo: el 95% de los tumores testiculares son de células germinales. La presencia de estas neoplasias ha venido en aumento, y se han hecho más frecuentes en gente jóven. Los tumores testiculares de células germinales se dividen en dos grupos: seminomatosos y no seminomatosos. El objetivo fue caracterizar los con base en los resultados de biopsia del Patología del Hospital México, del 1º de enero del 2003, al 31 de marzo del 2011. Métodos: estudio descriptivo de una base de datos del servicio de Patología, en donde se seleccionaron los tumores testiculares de células germinales. En el análisis, se calcularon frecuencias absolutas, relativas, intervalos de confianza, medidas de dispersión y de tendencia central y Chi cuadrado p< 0,05 para la tendencia. Resultados: se seleccionaron 148 casos con neoplasias de células germinales. Existe tendencia del aumento en los tumores con p < 0.003. El 60.2% (89 casos; IC 95% 52.2-68.1, se presentó en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos se presentaron en un 59.5% (88 casos, IC 95% (51.5-67.3; el promedio de edad para los no seminomatosos fue de 26.4 años, DE 8.1; y para los seminomatosos fue de 31 años, DE 7.5, con una diferencia calculada de p<0.001. Conclusiones: existe una tendencia significativa al aumento de los tumores testiculares de células germinales, que es más frecuente en menores de 30 años. Los tumores testiculares de células germinales no seminomatosos son los más frecuentes, cuyo promedio de edad es significativamente menor, que el de los TTCG seminomatosos. Se recomienda dirigir campañas de detección a población en riesgo y ampliar el estudio a otros hospitales.

  12. EMBOLIA GASEOSA CEREBRAL SECUNDARIA A BIOPSIA PULMONAR

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    Luís Rafael Moscote Salazar

    2008-01-01

    Full Text Available A 68-year-old male patient, underwent a lung biopsy. During the procedure, the patient had sudden loss of consciousness. A simple brain computed tomography was performed. Brain images showed multiple hypodenses areas in the brain parenchyma and subarachnoid space, making the diagnosis of cerebral gaseous embolism.Our case demonstrates the importance of considering the gaseous cerebral embolism when presented sudden loss of consciousness during invasive procedures such as lung biopsy or introduction of arterial and venous catheters.

  13. O papel da biopsia pulmonar na indicação cirúrgica de cardiopatias congénitas The role of lung biopsy in the decision-making process for congenital heart disease

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    Solange Bordignon

    1992-12-01

    Full Text Available Objetivando relacionar o aspecto morfológico dos vasos pulmonares com os dados clínicos para auxiliar na decisão da cirurgia de cardiopatias congênitas com hipertensão pulmonar severa, em casos previamente avaliados por critérios clínicos, angiográficos e/ou hemodinâmicos, foram realizadas, de 1980 a 1991, no Instituto de Cardiologia do Rio Grande do Sul, 49 biópsias pulmonares. As idades dos pacientes variaram de 5m a 28a6m (média = 7a7m e os diagnósticos foram: CIV (16, PCA (3, CIVe ESubAo (1, PCA e CIV (2, PCA e Cl A (1 DSAV (7, DSAV incompl. e PCA (1, PCA e CoAo (1, Inter Arco Ao com PCA e CIV e/ou ESupraM e Anel SubAo (2, DVSVD com CIV e/ou PCA (6, DVSVE e EP (1, ATe ESubP. (1, TGV (1, TGV corrigida e CIV (1 e truncus arteriosus (5. Houve 3 (6,1 % óbitos no pós-operatório da biopsia. Baseado na classificação de Heath-Edwards, foram para correção cirúrgica 11 pacientes com cardiopatias simples (CIV, PCA, DSAV, cuja mortalidade foi 36,4%. Dez pacientes com cardiopatias complexas (DVSVD, DVSVE, TGV, truncus, inter arco Ao foram para cirurgia, com mortalidade de 30%. A evolução pós-operatória tardia foi favorável em 13 (62% pacientes. Conclui-se que a biopsia pulmonar pode ser útil na indicação cirúrgica das cardiopatias congênitas com hipertensão pulmonar severa e, por envolver riscos, sua utilização deve ser criteriosa. E valiosa para os pacientes que apresentam dúvidas quanto ao grau de doença vascular pulmonar ou quanto à natureza das lesões e o estudo clínico e hemodinâmico não são esclarecedores, ou mesmo quando apontarem para a contra-indicação cirúrgica.Open lung biopsy has been performed in patients with congenital heart disease and severe pulmonary hypertension in order to complement the decision-making process for surgical correction. All patients had clinical, hemodynamic and angiographic evaluation previously and would not be surgical candidates by conventional criteria. The 49 patients

  14. Contrast-enhanced transrectal ultrasound for assessing vascularization of hypoechoic BPH nodules in the transition and peripheral zones: comparison with pathological examination.

    Science.gov (United States)

    Yang, Jing Chun; Tang, Jie; Li, Yanmi; Fei, Xiang; Shi, Huaiyin

    2008-11-01

    The purpose of this study was to investigate the vascularization of zonal location of hypoechoic benign prostatic hyperplasia (BPH) nodules and to evaluate the clinical value of contrast-enhanced transrectal ultrasound (CETRUS) for assessing vascularity of hypoechoic BPH nodules. Sixty-two patients with hypoechoic biopsy-proven BPH nodules in transition zone (TZ) (32 patients) or peripheral zone (PZ) (30 patients) of the prostate gland underwent CETRUS examination between January 2006 and September 2006. The enhancement characteristics of hypoechoic BPH nodules were observed and time to enhancement (AT), time to peak intensity (TTP) and peak intensity (PI) were measured with ACQ time-intensity curve analysis software. In addition, microvessel density (MVD) and vascular endothelial growth factor (VEGF) immunoreactivity were determined in the biopsy specimens. Microvessels were identified by immunohistochemical staining of endothelial cells for CD34. Findings were compared between hypoechoic BPH nodules located in PZ and TZ. The most common enhancement characteristic of hypoechoic BPH nodules in PZ was nonenhanced area inside (21/30), while most of hypoechoic BPH nodules in TZ appeared homogeneous enhancement (28/32). The average AT and TTP were significantly longer, the average PI was significantly lower in hypoechoic BPH nodules located in PZ than TZ (p BPH nodules located in TZ than PZ (p BPH nodules. Hypoechoic BPH nodules located in PZ and TZ showed significant difference in vascularization, which indirectly verified our finding that BPH nodule could occur in the peripheral zone. CETRUS could afford information on the vascularity of hypoechoic BPH nodules in a noninvasive manner and this could be used to improve selection of nodules for biopsy.

  15. The diagnostic ability of an additional midline peripheral zone biopsy in transrectal ultrasonography-guided 12-core prostate biopsy to detect midline prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, In Pyeong; Kim, Sang Youn; Cho, Jeong Yeon; Lee, Myoung Seok; Kim, Seung Hyup [Dept. of Radiology, Seoul National University Hospital and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul (Korea, Republic of)

    2016-01-15

    The goal of this study was to evaluate the diagnostic effect of adding a midline peripheral zone (PZ) biopsy to the 12-core biopsy protocol used to diagnose prostate cancer (PC), and to assess the clinical and pathologic characteristics of midline-positive PC in order to identify a potential subgroup of patients who would require midline PZ biopsy. This study included 741 consecutive patients who underwent a transrectal ultrasonography-guided, 12-core prostate biopsy with an additional midline core biopsy between October 2012 and December 2013. We grouped patients by the presence or absence of PC and subdivided patients with PC based on the involvement of the midline core. The clinical characteristics of these groups were compared, including serum prostate-specific antigen (PSA) concentrations, PSA density, and pathological features in the biopsy specimens. PC was detected in 289 patients (39.0%). Among the PC patients, 66 patients (22.8%) had midline PC. No patients were diagnosed with PC based only on a midline core. The Gleason scores, number of positive cores, tumor core length, serum PSA concentrations, and PSA density were significantly higher in patients with midline-positive PC (P<0.001). Furthermore, significant cancer was more frequent in the midline-positive group (98.5% vs. 78.0%). Patients showing a positive result for PC in a midline PZ biopsy were more likely to have multiple tumors or large-volume PC with a high tumor burden. However, our data indicated that an additional midline core biopsy is unlikely to be helpful in detecting occult midline PC.

  16. Ultrasound guided transrectal prostate biopsy:11-year experience%B超引导下经直肠前列腺穿刺临床分析

    Institute of Scientific and Technical Information of China (English)

    朱刚; 芦志华; 马宏; 闫伟; 万奔; 王建业

    2009-01-01

    Objective To summarize the experience in ultrasound guided transrectal prostate biopsy and analyze the influeneing factors of the biopsy results.Methods 687 patients with prostate specific antigen(PSA)>4μg,tubemles in prostate detected by digital rectal examination and/or prostate abnormality detected by magnetic resonance imaging,aged(70±8),underwent ultrasound guided transrectal 6-12 core prostate biopsy 1996-2007.Since 2006 the criteria for biopsy ineluded PSA of 4-10μg/ml,free PSA/total PSA ratio(F/T ratio)≤0.16,and PSA density>0.15.Results 269 of the 687 cases.witll the mean age of(72±8),were diagnosed as wlth pmstate cancer.294 and 121 of the 687patients(42.8%and 17.6%respectively)accepted prostate biopsy beeanse of elevated PSA or abnormality of DRE.The number of patients accepting prostate biopsy increased yearly(10 cases in 1996 to 98 cases in 2007).The positive biopsy rate was 39.8%.with the highest rate of 60.0%in 1999 and lowest rate of 30.4%in 2005.The highest number of prostate cancer diagnosed was the highest(42 cases)in 2007 and the lowest(4 cases)in 1996.PSA level was positively co-related with positive biopsy rate.The application of F/T ratio improved the positive biopsy rate in the patient with the PSA of 4-10μg/ml.The incidence rates of the main complications hematuria,bloody stool,and fever were 46.3%,8.7%,and 1.9%respectively.Conclusion Elevated PSA has become the most common resson for prostate biopsy.The combination with PSA.F/T ratio.and increased biopsy core number improve the positive biopsy rate.The ultrasound guided transrectal prostate biopsy is efficient and safe in the diagnosis of prostate cancer.%目的 总结B超引导下经直肠前列腺穿刺的经验并分析影响前列腺穿刺结果的因素.方法 统计卫生部北京医院1996-2007年行B超引导下经直肠前列腺穿刺病例.患者入选条件为前列腺特异抗原(PSA)>4μg/L,和(或)直肠指检发现前列腺结节,和(或)B超或磁共振成像(MRI)检

  17. UTILIDAD DE LA BIOPSIA RECTAL EN EL DIAGNÓSTICO DEL PACIENTE PEDIÁTRICO CON ESTREÑIMIENTO. EXPERIENCIA DE CINCO AÑOS EN UN CENTRO COLOMBIANO DE REFERENCIA The usefulness of rectal biopsy when diagnosing paediatric patients suffering from straining. Five year-experience in a Colombian reference centre (public hospital

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    Juan Carlos-Hiromi López T

    2011-09-01

    Full Text Available Antecedentes. El estreñimiento en la edad pediátrica es un problema de alta prevalencia que afecta aproximadamente al 8% de los niños. La mayoría de los pacientes no tienen una patología estructural de base y sólo en un pequeño porcentaje se encuentra una causa orgánica como las disganglionosis intestinales también llamadas neuropatías entéricas; es en estos casos donde la biopsia rectal juega un papel primordial para el diagnóstico. Objetivos. Determinar la incidencia de las neuropatías entéricas y las características de las biopsias colorectales realizadas para estudio del paciente con estreñimiento en el laboratorio de patología de la Fundación Hospital de la Misericordia en un periodo de cinco años. Material y métodos. Se revisaron y clasificaron las biopsias rectales remitidas para estudio por estreñimiento. Resultados. Se evaluaron 854 biopsias correspondientes a 272 casos, con un promedio de 3,13 muestras por paciente. En 183 casos se encontró histología normal (67,29%, en cincuenta y seis se estableció el diagnóstico de aganglionosis o enfermedad de Hirschsprung (20,59%, en dos el de displasia neuronal intestinal (DNI (0.74%, 8 pacientes se consideraron sospechosos de DNI (2.94% y los 22 restantes (8,1% fueron informados como material inadecuado para el estudio de neuropatía entérica. Conclusiones. Las biopsias rectales son un método útil para el diagnóstico de las neuropatías entéricas, sin embargo un porcentaje de ellas no permiten una adecuada interpretación. La disganglionosis más frecuente en esta serie fue la enfermedad de Hirschsprung con 56 casos, seguida por la displasia neuronal intestinal con tan sólo dos pacientes.Background. Straining occurs in around 8% of paediatric aged children. Most patients do not have base structural pathology and an organic cause, such as enteric neuropathy (also called Hirschsprung's disease or intestinal aganglionosis, is only found in a small percentage of them

  18. BACILOS ÁCIDO ALCOHOLRESISTENTES EN BIOPSIAS EMBEBIDASEN PARAFINA EN CASOS DE INFLAMACIÓNGRANULOMATOSA CRÓNICA. Detection of Acid-Fast Bacilli in Formalin-Fixed,Paraffin-Embedded Tissues of Patientswith Chronic Granulomatous Inflammation.

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    JAVIER ANDRÉS BUSTAMANTE

    Full Text Available La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pa-cientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspon-dientes a 30 pacientes (63,3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008. A cada muestra se le realizaron tres cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en pacientes con IGC necrotizante, reflejando una excelente concordancia en el diagnóstico (kappa=0,89, IC95%(0,68-1,0. Sin embargo, la tinción con Auramina fue superior a la tinción Ziehl Neelsen para la detección de BAAR en pacientes con IGC no necrotizante (kappa=0,65, IC95%(0,23-1,0. No se encontraron diferencias signi-ficativas entre la presencia de BAAR y el tipo de inflamacion, sexo y localización anatómica comprometida. En general, fue buena la concordancia entre los métodos histológicos empleados. Además, se hizo evidente la importancia de implementar el uso de técnicas moleculares mínimamente afectadas por el escaso número de bacilos presentes en las muestras, que finalmente ayudan en el reconocimiento del microorganismo.Detection of acid fast bacilli (AFB in smears is a significant aid in diagnosis and treatment of individuals with chronic granulomatous inflammation (CGI. This study was designed in order to detect the presence of AFB in several tissues of patients with

  19. Sentinel lymph node biopsy in patients with locally advanced breast cancer after neoadjuvant chemotherapy Biopsia do linfonodo sentinela em câncer na mama localmente avançado pós-quimioterapia neoadjuvante

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    Paulo Henrique Walter Aguiar

    2012-12-01

    Full Text Available PURPOSE: To check the rate of sentinel lymph node (SLN identification in patients with locally advanced breast cancer who underwent neoadjuvant chemotherapy comparing intraoperative contact cytology (imprint and embedded in paraffin and validation of methods. METHODS: A cross-sectional validation of diagnostic test involving 34 patients from the outpatient clinic of the Maternity School Assis Chateaubriand. The patients had locally advanced breast cancer and were treated with neoadjuvant chemotherapy. Those with clinically negative axilla underwent SLN biopsy, studied by imprint and histopathology in paraffin. All patients underwent axillary dissection and its histopathological study. RESULTS: The SLN identification rate was 85.3% (29/34. The sensitivity of imprint associated with paraffin on detection of metastasis compared to histopathology of the axillary content was 84.62% and specificity of 100% with false-negative rate of 12.01% and an accuracy of 92.77%. CONCLUSION: The search for metastases in the SLN by imprint and histopathological analysis in paraffin compared to the gold standard (axillary dissection had a low sensitivity with high rate of false negatives in our sample.OBJETIVO: Verificar a taxa de identificação do linfonodo sentinela (LS em pacientes portadoras de câncer na mama localmente avançado e que foram submetidos à quimioterapia neoadjuvante comparando a citologia de contato intraoperatória (imprint e a inclusão em parafina e validação dos procedimentos. MÉTODOS: Estudo transversal de validação de teste diagnóstico envolvendo 34 pacientes oriundas do Ambulatório da Maternidade-Escola Assis Chateaubriand. As pacientes eram portadoras de câncer na mama localmente avançado e foram tratadas com quimioterapia neoadjuvante. Àquelas com axila clinicamente negativa foram submetidas à biopsia do LS, esse estudado por impint e histopatologia em parafina. Todas as pacientes foram submetidas a esvaziamento axilar e seu

  20. Ganglio centinela en cáncer de mama: biopsia selectiva comparada con linfadenectomía axilar. Seguimiento a largo plazo Sentinel ganglion in breast cancer: selective biopsy compared with axillary lymphadectomy

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    E. Goñi

    2009-12-01

    Full Text Available Fundamento. La biopsia selectiva del ganglio centinela (BSGC ha reemplazado a la linfadenectomía axilar (LA, como procedimiento de elección, en el estadiaje del cáncer de mama en estadios iniciales y axila clínicamente negativa. El objetivo de este trabajo es comparar la supervivencia global y libre de eventos de aquellas pacientes a las que se realizó, en el periodo de validación de la técnica, BSGC seguida de LA respecto a las que se practicó BSGC y LA si el ganglio centinela (GC presentaba metástasis. Material y métodos. Se han incluido 148 pacientes, 81 pertenecientes al periodo de validación y 67 al grupo de aplicación clínica. El radiocoloide se administró intra-peritumoralmente, obteniéndose imágenes hasta la visualización del GC, posteriormente en la intervención quirúrgica se procedió a su identificación y extirpación. Resultados. En el grupo de validación, la eficacia de la técnica ha sido del 92,5%, la sensibilidad del 95,6% y la tasa de falsos negativos del 4%. De las 81 pacientes, 75 se encuentran libres de enfermedad (92,6%. De las 67 pacientes pertenecientes al grupo de aplicación clínica, 63 (94% viven libres de enfermedad. Ninguna paciente ha presentado recurrencia ganglionar axilar. Conclusiones. En la validación de la técnica hemos obtenido unos valores que se hallan dentro de las exigencias de calidad generalmente aceptadas. Con una media de seguimiento de 6 años no hemos observado recurrencia axilar en ninguno de los dos grupos. No existe diferencia estadísticamente significativa en la supervivencia global y libre de eventos entre ambos grupos.Background. Selective biopsy of the sentinel ganglion (SBSG has replaced axillary lymphadectomy (AL as the procedure of choice in staging breast cancer in its initial stages and in clinically negative axilla. The aim of this study is to compare global event-free survival of those patients subjected to SBSG followed by AL, during the period of validation of

  1. Application value of transrectal ultrasonography with transvaginal probe in diagnosis of polycystic ovary syndrome among unmarried women%阴式探头经直肠超声在诊断未婚女性多囊卵巢综合征中的应用价值

    Institute of Scientific and Technical Information of China (English)

    魏敏; 范丽梅; 翟萍; 王胜文

    2011-01-01

    Objective: To explore the clinical application value of transrectal ultrasonography with transvaginal probe in diagnosis of polycystic ovary syndrome among unmarried women. Methods: The results of 120 unmarried women with polycystic ovary s]drome examined by transabdominal ultrasonography and transrectal ultrasonography were compared. Results: The detection rates of transabdominal ultrasonography and transrectal ultrasonography in diagnosis of polycystic ovary syndrome among unmarried women were 31.14% and 90. 73%,respectively. Conclusion: Transrectal ultrasonography can increase the diagnosis rate of polycystic ovary syndrome among unmarried women,which is worthy to be popularized.%目的:探讨阴式探头经直肠超声检查诊断未婚女性多囊卵巢综合征的临床应用价值.方法:比较经腹部超声与经直肠超声检查未婚女性多囊卵巢综合征的患者120例.结果:经腹部超声诊断未婚女性多囊卵巢综合征,检出率只有31.14%,而经直肠超声检查诊断符合率可达90.73%.结论:经直肠超声可提高未婚女性多囊卵巢综合征的诊断率,值得临床推广使用.

  2. Biopsia por aspiración y supresión con hormonas tiroideas en el diagnóstico de cáncer tiroideo: comparación con la cirugía en 77 nódulos hipocaptantes Fine-Needle aspiration biopsy and suppression with thyroid hormone in the diagnosis of thyroid carcinoma

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    Humberto Aristizábal

    1992-01-01

    Full Text Available Se estudiaron 77 pacientes con nódulos tiroideos hipocaptantes, demostrados por gamagrafía, por medio de biopsia tiroidea por aspiración y terapia supresiva con hormonas tiroideas durante 6 meses o más. Se realizó estudio ecográfico del nódulo antes de iniciar la terapia y seis meses después de estarla administrando. Todos fueron intervenidos porque en ninguno desapareció el nódulo con la terapia, a pesar de que se obtuvo supresión de la tirotrofina en plasma. La biopsia tiroidea por aspiración (BT A fue Interpretada en todos los pacientes como bocio coloide o nodular o neoplasia folicular. En contraste, en el estudio de la pieza quirúrgica 52 pacientes presentaron bocio nodular, multinodular o coloide; 16 tenían carcinomas (12 papilares y 4 foliculares y 9 tiroiditis de Hashimoto. Contrariamente a lo esperado se observó que 5 de loS carcinomas (31.3% disminuyeron de volumen durante el tratamiento hormonal; de acuerdo a la ecografía la disminución promedio fue 0.41 cm3. En cambio 4 de los 52 nódulos benignos (7.7% aumentaron de volumen, en promedio 3.7 cm3. Estos hallazgos sugieren que la prueba de supresión con hormonas tiroideas no es confiable para definir si una lesión es benigna o maligna. En el estudio quirúrgico se demostró que 20.8% (16/77 de los nódulos eran carcinomas. A la luz de estos datos la biopsia por aspiración no estableció por lo general el diagnóstico de carcinoma; por ello se debe recurrir a la cirugía aunque la biopsia sea negativa.

    Seventy-seven patients with cold thyroid nodules were studied with flne-needle aspiration biopsy and suppression with thyroid hormone. The volume of the nodule was calculated ultrasonographycally at the beginning of the study and after six months of oral therapy with thyroglobulin, at doses sufficient to maintain TSH at the low limits of the normal

  3. Segurança e eficácia da técnica de biopsia pulmonar transtorácica percutânea para avaliação histopatológica do parênquima pulmonar de ovinos clinicamente sadios Safety and effectiveness of the transthoracic percutaneous lung biopsy technique for histopathological evaluation of the lung parenchyma in healthy sheep

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    Andreza Amaral da Silva

    2010-04-01

    Full Text Available Foram analisados os resultados e complicações decorrentes do emprego da técnica de biopsia pulmonar transtorácica percutânea em 20 ovinos clinicamente sadios. Os animais foram submetidos ao exame clínico seguido da biopsia com agulha semi-automática no 7º espaço intercostal direito, 5cm acima do olécrano. Foram analisados o número de tentativas para a execução do procedimento e o tamanho dos fragmentos. As amostras obtidas foram avaliadas histologicamente. Posteriormente ao abate, foi realizado o exame pos mortem para avaliação de complicações da técnica e das eventuais lesões provocadas. Entre todos os animais submetidos à biopsia apenas dois demonstraram resistência a técnica, sendo obtidos fragmentos pulmonares de 4-7mm de comprimento, com média de 1,8±1 tentativas por fragmento. As principais alterações relacionadas à técnica foram tosse, dispnéia inspiratória, elevação das freqüências cardíaca e respiratória e aumento do ruído broncobronquiolar. Ao exame post mortem observou-se hemorragia dos músculos intercostais e pleura visceral em todos os animais. Das 20 tentativas de execução da técnica, 18 obtiveram sucesso, enquanto que em duas o fígado foi equivocadamente puncionado. As amostras de tecido pulmonar foram consideradas representativas, pois foi possível a visualização de estruturas íntegras, incluindo bronquíolos e alvéolos. Podemos concluir que a biopsia pulmonar é segura e eficaz para obtenção de amostras pulmonares com fins de diagnóstico histológico.The results and complications arising from use of the percutaneous transthoracic lung biopsy technique in 20 clinically healthy sheep were analyzed. The animals were subjected to clinical examination followed by lung biopsy with a semi-automatic needle in the 7th right intercostal space, 5cm above the olecranon. The number of attempts to implement the procedure and size of the fragments were evaluated. The samples were evaluated

  4. Inflamación Granulomatosa Crónica: Métodos de detección de bacilos ácido alcohol resistentes en biopsias embebidas en parafina

    Directory of Open Access Journals (Sweden)

    Bustamante Rengifo Javier Andres

    2010-08-01

    Full Text Available

    La detección de bacilos ácido alcohol resistentes (BAAR en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC. Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con IGC demostrada y comparar la frecuencia de los extendidos positivos para BAAR con el grado de formación de granulomas y necrosis, se diseño un estudio retrospectivo, en el que se seleccionaron 57 bloques embebidos en parafina que contenían biopsias de pleura, pulmón, pericardio, ganglio linfático y lóbulo cerebral, correspondientes a 30 pacientes (63.3% hombres, mayores de 18 años, con IGC demostrada y remitidos al departamento de patología del Hospital Universitario del Valle entre el 2002-2008, a cada muestra se le realizaron 3 cortes y se sometieron a tinciones de H/E, Zielh Neelsen y Auramina. La detección de BAAR en frotis fue similar para ambas tinciones especiales en

  5. Pathologic diagnosis and Gleason grading of prostatic carcinoma by transrectal ultrasound-guided prostate needle biopsy%穿刺活检前列腺癌72例病理形态学观察及Gleason分级

    Institute of Scientific and Technical Information of China (English)

    王云帆; 缪琦; 王淑芳; 饶晓松

    2013-01-01

    目的 观察经直肠超声引导的前列腺癌穿刺活检组织的病理形态学改变,进行系统的Gleason分级.方法 收集经直肠超声引导的前列腺穿刺活检诊断的前列腺癌72例,复习HE组织切片,并依据2005年国际泌尿病理学协会(ISUP)修订的前列腺癌Gleason分级系统进行分级.结果 72例前列腺癌中53例的主要及次要成分为3级结构(73.6%),59例主要及次要成分为4级结构(81.9%),12例主要及次要成分为5级结构(16.7%).结论 本组前列腺癌Gleason 4级结构与3级结构常常混合存在,而且4级结构相比3级结构更为常见.修订后的Gleason分级系统有助于对前列腺癌进行规范分级,以利于进一步研究,准确反映肿瘤的预后差异.%Objective To study the morphological diagnostic criteria and Gleason grading of prostatic carcinoma in transrectal ultrasound guided prostate needle biopsy. Methods 72 cases of prostatic needle biopsy guided by transrectal ultrasound were reviewed. Routine pathological examination was used in the study. Data with respect to Gleason grading were studied according to the refinements of the ISUP 2005 consensus conference on Gleason grading of needle biopsies. Results The results showed that Gleason pattern 3 was seen in 73. 61% ; pattern 4 in 81. 94% ; pattern 5 in 16. 67% among 72 cases of prostatic carcinoma. Conclusions Most of the tumors show at least two different patterns, and the pattern 4 is more common than pattern 3. The use of modified Gleason scoring leads to improves the prognostic value of the patients with prostate cancer and can be more accurately assessed in transrectal ultrasound guided prostate needle biopsy. Continued effort is required to refine biopsy strategies to Gleason grading of prostatic specimens.

  6. 经直肠彩色多普勒超声对前列腺癌的诊断价值%Value of transrectal color Doppler ultrasound in diagnosis of prostatic carcinoma

    Institute of Scientific and Technical Information of China (English)

    易发现; 李永忠; 李响

    2012-01-01

    Objective To evaluate the clinical value of transrectal color Dopplei ultrasound in diagnosis of prostatic carcinoma. Methods Thiity-one patients with prostatic carcinoma were examined by transrectal color Dopplei ultrasound, and 31 patients with benign hyperplasia were involved as the control group. Then the shape, lesion size, internal echo oi prostate, membranes and whether metastasis in surrounding organs in two groups were observed. Blood flow distribution of prostate and interior and periphery of the lesions were observed with color Doppler flow imaging( CDFI) , the internal diameter, the peak velocity and resistance index of the art ray were measured. Results Prostatic carcinoma was associated with calcification with the form of cluster, weak echoes, increased blood flow, increased resistance index, respectively. Multivariant logistic regression showed increased blood flow and increased resistance index were independent risk factors of prostatic carcinoma( P= 0. 011 ,OR= 17. 3 16 ;P= 0. 007 , OR = 14. 068). Conclusion Transrectal color Doppler ultrasound can improve the diagnostic accurate rate of prostate cancer.%目的 评价经直肠彩色多普勒超声诊断前列腺癌的临床价值.方法 应用经直肠彩色多普勒超声对31例前列腺癌(试验组)进行检查,同时选取31例良性前列腺增生患者为对照组,观察两组前列腺形态、病灶大小及内部回声情况,包膜的完整及周边邻近器官是否有转移灶.然后应用彩色多普勒超声观察前列腺及结节内部、周边血流分布状态、测量血管内径并记录动脉频谱的峰值,计算阻力指数.结果 前列腺癌与簇状钙化、低回声、回声不均、血流信号增强、阻力指数升高等有关,经Logistic回归分析,血流信号增强和阻力指数增高分别是前列腺癌的独立危险因素(P=0.011,OR=17.316;P=0.007,OR=14.068).结论 经直肠彩色多普勒超声能提高前列腺癌的诊断准确率.

  7. Diagnostic Value of Transrectal Ultrasonics in Prostatic Adenocarcinoma and Urethral Invasion%直肠超声对前列腺癌及其侵及尿道的诊断价值

    Institute of Scientific and Technical Information of China (English)

    林礼务; 林晓东; 俞丽云; 叶真; 薛恩生; 何以敉; 高上达

    2001-01-01

    目的提高直肠超声检查对前列腺癌(PCA)及其侵及尿道的诊断水平。方法对42例病理证实的PCA(其中6例侵及尿道)及15例正常前列腺进行经腹壁与直肠超声检查、直肠指诊及血清PSA测定的对比观察。结果直肠超声、直肠指诊、PSA测定与腹部超声对42例PCA患者的诊断阳性率分别为66.7%(28/42)、42.9%(18/42)、81.0%(34/42)与33.3%(14/42)。对PCA侵及尿道的诊断阳性率也分别为83.3%(5/6)、66.7%(4/6)、83.3%(5/6)与33.3%(2/6)。结论直肠超声检查如发现前列腺不对称增大,包膜欠光滑或突向膀胱或前列腺内见低回声结节与杂乱回声区,应高度怀疑PCA并应结合血清PSA测定与直肠指诊等综合判断。%PurposeTo raise the transrectal ultrasonic diagnostic level of the prostatic adenocarcinoma as well as the urethral invasion. MethodsForty-two patients with the prostatic adenocarcinoma and fifteen cases with the normal prostata were respectively examined by the transrectal ultrasonography, the transabdominal ultrasonography and the rectal touch. The serum PSA of each case was also examined. Results The positive rates of the transrectal ultrasonography, the rectal touch., the serum PSA determination and the transabdominal ultrasonography of the prostatic adenocarcinomas of the 42 patients were 66.7%(28/42), 42.9%(18/42), 81.0%(34/42) and 33.3%(14/42) respectively. The positive rates of the methods mentioned above of the urethral invasion were 83.3%(5/6), 66.7%(4/6), 83.3%(5/6) and 33.3%(2/6). Conclusion The diagnostic accurate rate would be raised if the patients who are suspected with the prostatic adenocarcinoma are examined by the different ways mentioned above.

  8. Changes of Abdominal Ultrasound and Transrectal Ultrasound Detection of Prostate%腹部超声与直肠腔超声检测前列腺疾病的差异变化

    Institute of Scientific and Technical Information of China (English)

    王硕

    2015-01-01

    目的:探讨腹部超声与直肠腔超声检测前列腺疾病的差异变化。方法选取72例前列腺疾病患者,比较腹部超声和直肠腔内超声检测的差异。结果经腹部超声及直肠腔内超声检测,3组患者的前列腺前后径、左右径均超出正常范围,C组患者前列腺前后径、左右径明显长于A组、B组,差异有统计学意义(P<0.05)。直肠腔内超声诊断前列腺疾病癌、囊肿、增生、钙化的准确率均明显高于腹部超声,差异均有统计学意义(均P<0.05)。结论与腹部超声比较,直肠腔内超声在诊断前列腺疾病方面具有更高的灵敏性和准确性。%Objective To observe the difference of abdominal ultrasound and endorectal ultrasound in detection of prostatic diseases.Methods According to the age characteristics,72 patients with prostate disease in our hospi- talpatients were divided into 3 groups,A group(50~59 years old),B group(60~69 years old),C group(70~79 years old),24 cases in each group,the compared the difference between abdominal ultrasound and endorectal ultrasound. Results The abdominal ultrasound and transrectal ultrasound,3 groups of patients before and after the prostate size,diameter were beyond the normal range,and C group of patients with prostate size,diameter was significantly longer than that in A group,B group,the difference was statisticaly significant(P<0.05).The accuracy of transrectal ultrasound in diagnosis of prostate diseases, cancer, proliferation,calcification of the cyst was significantly higher than that of abdominal ultrasound,the differences were statisticaly significant(P<0.05).Conclusion Compared with transabdominal ultrasound,transrectal ultrasonography has higher sensitivity and accuracy in the diagnosis of prostate disease.

  9. Magnetic resonance imaging-targeted, 3D transrectal ultrasound-guided fusion biopsy for prostate cancer: Quantifying the impact of needle delivery error on diagnosis

    Energy Technology Data Exchange (ETDEWEB)

    Martin, Peter R., E-mail: pmarti46@uwo.ca [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Cool, Derek W. [Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7, Canada and Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Romagnoli, Cesare [Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Fenster, Aaron [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Department of Medical Imaging, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Robarts Research Institute, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Ward, Aaron D. [Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 3K7 (Canada); Department of Oncology, The University of Western Ontario, London, Ontario N6A 3K7 (Canada)

    2014-07-15

    Purpose: Magnetic resonance imaging (MRI)-targeted, 3D transrectal ultrasound (TRUS)-guided “fusion” prostate biopsy intends to reduce the ∼23% false negative rate of clinical two-dimensional TRUS-guided sextant biopsy. Although it has been reported to double the positive yield, MRI-targeted biopsies continue to yield false negatives. Therefore, the authors propose to investigate how biopsy system needle delivery error affects the probability of sampling each tumor, by accounting for uncertainties due to guidance system error, image registration error, and irregular tumor shapes. Methods: T2-weighted, dynamic contrast-enhanced T1-weighted, and diffusion-weighted prostate MRI and 3D TRUS images were obtained from 49 patients. A radiologist and radiology resident contoured 81 suspicious regions, yielding 3D tumor surfaces that were registered to the 3D TRUS images using an iterative closest point prostate surface-based method to yield 3D binary images of the suspicious regions in the TRUS context. The probabilityP of obtaining a sample of tumor tissue in one biopsy core was calculated by integrating a 3D Gaussian distribution over each suspicious region domain. Next, the authors performed an exhaustive search to determine the maximum root mean squared error (RMSE, in mm) of a biopsy system that gives P ≥ 95% for each tumor sample, and then repeated this procedure for equal-volume spheres corresponding to each tumor sample. Finally, the authors investigated the effect of probe-axis-direction error on measured tumor burden by studying the relationship between the error and estimated percentage of core involvement. Results: Given a 3.5 mm RMSE for contemporary fusion biopsy systems,P ≥ 95% for 21 out of 81 tumors. The authors determined that for a biopsy system with 3.5 mm RMSE, one cannot expect to sample tumors of approximately 1 cm{sup 3} or smaller with 95% probability with only one biopsy core. The predicted maximum RMSE giving P ≥ 95% for each

  10. Detection and localization of carcinoma within the prostate using high resolution transrectal gamma imaging (TRGI) of monoclonal antibody directed at prostate specific membrane antigen (PSMA)—Proof of concept and initial imaging results

    Energy Technology Data Exchange (ETDEWEB)

    Franc, Benjamin L., E-mail: francbl@radiological.com [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Cho, Steve Y. [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); Rosenthal, Seth A. [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Cui, Yonggang [Brookhaven National Laboratory, 2 Center Street, Upton, NY 11973 (United States); Tsui, Benjamin [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); Vandewalker, Kristen M.N. [Diagnostic Pathology Medical Group, 3301 C. Street, Suite 200E, Sacramento, CA 95816 (United States); Holz, Andrew L.; Poonamallee, Uday [Radiological Associates of Sacramento Medical Group, 1500 Expo Parkway, Sacramento, CA 95815 (United States); Pomper, Martin G. [Department of Radiology, Johns Hopkins University, 600 N. Wolfe Street, Baltimore, MD 21287 (United States); James, Ralph B. [Brookhaven National Laboratory, 2 Center Street, Upton, NY 11973 (United States)

    2013-11-01

    Purpose: Molecular imaging methods may identify primary prostate cancer foci and potentially guide biopsy and optimal management approaches. In this exploratory study, safety and first human imaging experience of a novel solid state endocavity transrectal gamma-imaging (TRGI) device was evaluated. Methods: Twelve patients received 5 ± 0.5 mCi In-111 capromab pendetide (ProstaScint{sup ®}) intravenously and the prostate of each was imaged 4 days later transrectally using an endoluminal cadmium zinc telluride (CZT)-based compact gamma camera (ProxiScan™, Hybridyne Imaging Technologies, Inc.). Immediate and 5–7-day post imaging safety assessments were performed. In those patients with a prostate cancer diagnosis (N = 10), single photon emission computed tomography (SPECT-CT) and magnetic resonance imaging (MRI) of the pelvis were also acquired. Images were reviewed and sites of suspected cancer were localized by prostate quadrant by consensus of two nuclear medicine physicians. Pathology from TRUS biopsy, or surgical pathology following prostatectomy (N = 3) when available, served as the gold standard. Results: There were no serious adverse events associated with TRGI. No focal signal was detected in patients without a diagnosis of prostate cancer (N = 2). Of 40 quadrants evaluated in the cancer cohort (N = 10), 22 contained malignancy. In 8 of these 10 patients, the most focal site of uptake on TRGI corresponded to a prostatic quadrant with biopsy-proven malignancy. In 6 cancer-containing quadrants, TRGI was positive where SPECT-CT was negative; MRI showed a detectable abnormality in only 1 of these 6 quadrants. Qualitative image review of the planar TRGI images for prostate cancer localization was severely limited in some cases by scatter artifact within the vicinity of the prostate gland arising from physiologic urine and blood pool activity from nearby structures. Conclusions: TRGI is a safe imaging method that can potentially detect radiopharmaceutical

  11. New kidney immobilization method for percutaneous renal biopsy technique in cats: Operational aspects and complications Novo método de imobilização do rim para biopsia renal percutânea em gatos: Aspectos operacionais e complicações

    Directory of Open Access Journals (Sweden)

    Daniele Alves Silva

    2012-01-01

    Full Text Available PURPOSE: Evaluate a new immobilization kidney method for collecting blind percutaneous renal biopsies (RB in healthy cats. METHODS: Ten cats were biopsied by a modified blinded percutaneous technique using semi-automated needles. Were evaluated the operational aspects of the technique, its complications, and the quality of the obtained samples. The evaluation included physical examination, hemogram, urinalysis, abdominal ultrasound, renal function, and histopathology of the biopsy specimens. RESULTS: The developed technique was fast and easy to perform; it required two operators, and the right kidney was elected for specimen collection. After the RB, a decrease in hematocrit levels was observed in addition to hematuria and perirenal transient hematoma; however, no clinical consequences were observed, and normal parameters were restored within 48 hrs. There were no major complications or deaths, alterations in the physical examination or renal function, or signs of infection. Of the samples, 95% revealed the presence of renal tissue, and in 100% of the cats the samples were of diagnostic quality. CONCLUSION: The technique was easily performed, provided adequate material for diagnosis with minimal transient complications.OBJETIVO: Avaliar um novo método de imobilização do rim para coleta de biopsia renal (BR percutânea às cegas em gatos hígidos. MÉTODOS: Dez gatos foram biopsiados por uma técnica de biopsia percutânea às cegas modificada, com uso de agulha semi-automática. Foram avaliados os aspectos operacionais da técnica, complicações e a qualidade das amostras obtidas. A avaliação incluiu exame físico, hemograma, urinálise, ultrassonografia abdominal, função renal e análise histopatológica do espécime de biopsia. RESULTADOS: A técnica foi de fácil realização; foram requeridos dois operadores, e o rim direito foi eleito para a coleta da BR. Após a BR, diminuição do hematócrito foi observada, em conjunto com hemat

  12. Fisher criteria vs. thyroid aspiration citology in the diagnosis of hashimoto's thyroiditis Valor de cuatro de los criterios de Fischer comarados con la biopsia tiroidea por aspiración en el diagnóstico de la tiroiditis de Hashimoto

    Directory of Open Access Journals (Sweden)

    Constanza Díaz González

    1991-02-01

    Full Text Available

    One hundred and forty one patients with diffuse goiter were studied In order to evaluate four of Fisher's criteria for the diagnosis of Hashimoto's thyroiditis and to compare them with the result of thyroid aspiration biopsy. The following criteria were Included in the analysis: a physical characteristics of the gland; b appearance of the radioisotope scan; c plasma TSH concentration; d serum tilters of antithyroid antibodies. It was found that neither criteria was satisfactory in terms of sensitivity or specificity when compared with the result of the aspiration cytology. Ac. cordingly, we favor the use of the latter provided that adequate material is obtained and that an expert reading is performed.

    Se hicieron estudios clínico y de laboratorio y biopsia tiroidea por aspiración a 133 mujeres y 8 hombres con bocio difuso, de la Consulta Externa del Instituto de Seguros Sociales de Medellín, con el fin de comparar el valor diagnóstico de cuatro de los cinco criterios de Fisher con el de dicha biopsia, en la tiroiditis de Hashimoto. El diagnóstico citológico fue bocio simple (nodular, multinodular O coloide en 130 casos (92.2% y tiroiditis de Hashimoto en 11 (7.8%. Se aplicó la prueba tamiz a los criterios de Fisher, aisladamente O en grupos, con resultados deficientes en cuanto a sensibilidad y especificidad. Los criterios analizados fueron: a glándula moderadamente crecida, difusa y firme; b captación tiroidea Irregular; c TSH plasmática elevada; y d anticuerpos antitiroideos positivos a muy altas diluciones (≥:1 :25.000. La captación tiroidea Irregular tuvo la mayor sensibilidad (90% pero su especificidad fue sólo 11 %. En contraste, la sensibilidad y la especificidad de los títulos altos de anticuerpos antimicrosomales fueron 78% 71 %, respectivamente.

  13. 不育男性前列腺中线囊肿经直肠超声检查及精液特点分析%Transrectal ultrasonographic features of midline prostatic cysts in infertile men and their semen analysis

    Institute of Scientific and Technical Information of China (English)

    顾怡栋; 邓学东; 杨慎敏; 姜纬; 李红

    2015-01-01

    目的分析男性不育患者前列腺中线囊肿经直肠超声表现和精液特点。方法对2013年11月至2014年10月在南京医科大学附属苏州医院超声中心就诊的34例男性不育患者经直肠超声表现及精液特点进行分析。结果34例男性不育超声显示前列腺中线囊肿的患者声像图均表现为前列腺内无回声区,其中射精管囊肿17例,囊肿一侧与同侧精囊相连,纵切面声像图示囊肿呈倒置水滴状尖端指向精阜;苗勒管囊肿11例,囊肿位于前列腺基底部、尿道后上方中线处,纵切面声像图呈水滴状或类圆形;真性前列腺囊肿6例,囊肿位于前列腺内部或前列腺包膜下,横切面及纵切面声像图呈圆形或类圆形,根据囊肿的解剖位置及形态可加以鉴别。精液检测分析提示射精管囊肿患者中无精子症13例,少精子症2例;苗勒管囊肿患者中无精子症4例,少精子症6例;真性前列腺囊肿患者中无精子症1例,少精子症2例。结论经直肠超声检查可对前列腺中线囊肿解剖位置及形态做出准确诊断,与精液分析相结合可为临床治疗提供可靠的依据。%Objective To investigate the transrectal ultrasonographic (TRUS) features of midline prostatic cysts and the semen analysis in infertile men. Methods The ultrasonographic characteristics of midline prostatic cysts were retrospectively analyzed in 34 infertile men, who underwent transrectal ultrasound and semen analysis in Suzhou Hospitial Affiliated to Nanjing Medical University from November 2013 to October 2014. Results Thirty-four patients were detected by transrectal ultrasound with anechoic areas in their prostates. Among them, the cysts could be divided into 3 groups:17 ejaculatory duct cyst, 11 mullerian duct cyst and 6 true prostatic cyst. Ejaculatory duct cysts was connected with ipsilateral seminal vesicle and pointed to seminal hillock showing a water-drop shape on longitudinal

  14. Determinación de la utilidad de la relación APE l/t (Antígeno Prostático Específico libre sobre el total en pacientes con sospecha de cáncer de próstata estudiados por biopsia ecográfica endorrectal Utility of Free/Total Serum Prostate-Specific Antigen Ratio in prostatic cancer studied with endorectal ultrasound biopsy

    Directory of Open Access Journals (Sweden)

    Alberto Marangoni

    2008-09-01

    Full Text Available Introducción: Los marcadores tumorales son importantes al momento de decidir la realización de biopsias para el diagnóstico de cáncer de próstata. El objetivo de este trabajo es evaluar la exactitud diagnóstica del APE libre como marcador tumoral en casos de pacientes con sospecha de cáncer prostático en su relación con el APE total (APEL/T y determinar un valor de corte ajustado. Material y Método: En total, fueron evaluados 248 pacientes de entre 38 y 88 años de edad, en un período comprendido entre noviembre de 2001 y junio de 2007, con un análisis del APE libre, identificación de la presencia de un área hipoecogénica como ayuda diagnóstica y un análisis anatomopatológico para confirmación pospunción prostática endorrectal, realizado en forma prospectiva. Resultados: La identificación de pacientes con cáncer de próstata a través de la sospecha por el APE libre es relativa pero puede ser potenciada con otros hallazgos. Un 23,3% de pacientes con APEL/T por debajo de 0,20 presentaron biopsias positivas, pero, con un valor de 0,14, el porcentaje fue del 60%. Discusión: La identificación de pacientes para ser estudiados mediante Biopsia Prostática Endorrectal (BPE es un problema de la práctica diaria en los consultorios de Urología. Debido a que la BPE es un procedimiento diagnóstico medianamente invasivo y no exento de morbilidad, es que se debería ajustar su indicación. La relación APEL/T debe ser considerada en este contexto con mayor importancia. Conclusión: La identificación de valores alterados de la relación APE L/T con un valor de corte ajustado a 0,14 puede ayudar en el diagnóstico presuntivo de cáncer de próstata y a la elección de pacientes para biopsia a fin de ahorrar biopsias innecesarias.Introduction: The tumor markers are important to decide to perform biopsies in the prostate cancer diagnosis. The goal of this article is to evaluate the diagnosis precision of FPSA (Free Prostatic Specific

  15. Research on the prediction of the outcome of medical abortion by transrectal ultrasonography%经直肠超声检查预测药物流产结局的研究

    Institute of Scientific and Technical Information of China (English)

    郭玮; 郭敏

    2012-01-01

    目的 探讨经直肠超声在预测药物流产结局方面的临床应用价值.方法 选择120例无任何合并症和并发症的药物流产妇女,于药物流产后第3天经直肠超声观察宫腔情况.根据宫腔内容物血流信号特征,分为Ⅰ、Ⅱ、Ⅲ型;根据宫腔内容物最大前后径,分为A(<10.0 mm)、B(11.0~30.0 mm)和C(>30.0 mm)三组;并随访各组药物流产结局.结果 Ⅰ、Ⅱ、Ⅲ型患者药流成功率依次为95.83%、31.03%、0;清宫率依次为0、17.24%及100%;A、B、C三组患者药流成功率依次为94.67%、3.03%、0;清宫率依次为0、24.24%、100%,且各组间比较差异有统计学意义(P<0.05).此外,随着血流信号丰富程度的增加,宫腔内容物大小呈逐渐上升趋势,差异有统计学意义(P<0.01).结论 应用直肠超声观测宫腔情况对预测药物流产结局有一定的指导意义.对于宫腔内容物血流信号丰富且体积较大的药物流产患者,应加强监测,可积极行清宫术.%Objective To explore the value of transrectal ultrasonography in predicting the outcome of medical abortion. Methods One hundred and twenty women who received medical abortion without any complications were enrolled in the study. Transrectal ultrasonography was performed to observe the situation of uterine cavity three days after medical abortion. Subjects were divided into group I , II and IE according to the features of blood flow signal in uterine cavity contents. Subjects were divided into group A(30.0 mm) according to the maximum diameter of uterine cavity contents. The outcome of medical abortion in all groups was followed. Results The success rate of medical abortion of group I , II and IH was 95.83% , 31.03% and 0, while the ratio of additional curettage was 0, 17.24% and 100% , respectively. By contrast, the success rate of medical abortion of group A, B and C was 94.67% , 3.03% , and 0, and the ratio of additional curettage was 0, 24.24% and

  16. The diagnostic values of serum prostate specific antigen and transrectal contrast-enhanced ultrasonography of prostate cancer%血清 PSA 指标与经直肠超声造影对前列腺癌的诊断

    Institute of Scientific and Technical Information of China (English)

    朱林; 黄君; 詹洁群; 贾天利; 刘灿

    2015-01-01

    目的:探讨血清前列腺特异性抗原(PSA)指标,游离前列腺特异性抗原(f-PSA)、总前列腺特异性抗原(T-PSA),前列腺特异性抗原密度(PSAD)与经直肠前列腺超声造影对前列腺癌(Prostate Cancer,PCa)的诊断价值。方法:获取59例血清 PSA 升高的患者的 fPSA 及 T-PSA、前列腺体积的三个径(L、W、H),所有病例均经直肠超声造影检查,并在超声引导下进行前列腺穿刺。结果:前列腺癌组患者的发病年龄要比良性前列腺增生(Benign prostate hyperplasia,BPH)组大,PSAD 比 BPH 组高。前列腺癌组的 f/T-PSA 比良性前列腺增生组低。前列腺癌组患者的显影时间、达峰时间、加速时间较良性前列腺增生组患者短,绝对增强强度较良性前列腺增生组高。前列腺癌组患者的强度减半时间比良性前列腺增生组患者短。结论:前列腺癌组的前列腺造影结果表现为“快进快出”。血清 f/T-PSA、PSAD 及经直肠超声造影技术对前列腺良恶性病变的鉴别诊断具有一定的临床价值。%Aim:To study the value of serum PSA indicator (f/T-PSA,PSAD)and CETRUS (con-trast-enhanced transrectal ultrasound)in diagnosis of prostate cancer.Methods:Fifty-nine patients were elevated with serum PSA had fPSA (free prostate specific antigen)and T-PSA (total prostate specific an-tigen),three size (Long,Wide,Height),the 59 patients carry through CETRUS (contrast-enhanced transrectal ultrasound)and biopsy.Results:Prostate cancer patients’age of onset are older than benign prostate hyperplasia group,PSAD in prostate cancer group are higher than that of benign prostate hyper-plasia group,f/T-PSA in prostate cancer group are lower than that of benign prostate hyperplasia group. AT (arrival time),TTP (time to peak),ACT (acceleration time)in prostate cancer group are shorter than those of benign prostate hyperplasia group,absolute enhance intense (△PI =PI

  17. AB226. The effects of transrectal radiofrequency hyperthermia on patients with chronic prostatitis and the changes of IL-8, IL-10, TNF-α, PGE2, β2-endorphin levels in pre-treatment and post-treatment

    Science.gov (United States)

    Ding, Hui; Gao, Mingdong; Lu, Jianzhong; Wang, Hanzhang; Li, Qinfang; Wang, Zhiping

    2014-01-01

    Objective To assess the effectiveness of transrectal radiofrequency hyperthermia in men with chronic prostatitis (CP), and explore the changes of IL-8, IL-10, TNF-equency hyperthermia in men wi CP patients pre-treatment and post-treatment. Materials and methods Patients diagnosed with chronic prostatitis were randomized to 6 weeks of tamsulosin plus clarithromycin, transrectal radiofrequency hyperthermia (TRFH) or TRFH with tamsulosin plus clarithromycin group, respectively. The primary outcome measure was evaluated by the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). The expression of EPS interleukin-8 (IL-8), interleukin 10 (IL-10), tumor necrosis factor (TNF-α), prostaglandin E2 (PGE2) and β2-endorphin (βNIH-) were detected by ELISA in the pre-treatment and post-treatment of CP. Results A total of 159 patients were randomized in the study. The NIH-CPSI total, domain and pain scores significantly decreased from baseline in all groups, After treatment, IL-8 and IL-10 was significantly decreased in the TRFH with tamsulosin plus clarithromycin group compared to the other two groups(P<0.05), Among the three groups, there was no significant changes of TNF-, domain and pain scores significantly, the levels of PGE2 was significantly decreased (P<0.05), while the TNF-, domain and pain scores significantly decreased from baseline in all groin plus clarithromycin group compared to the tamsulosin plus clarithromycin group (P<0.05). In the CP patients, the results showed that there was a significant negative correlation between β2-EP and pain (r=–0.747, P<0.05) or QoL (r=–0.595, P<0.05), while there was a significant positive correlation between TNF-α and micturition (r=0.619, P<0.05) or QoL (r=0.663, P<0.05), between PGE2 and pain (r=0.650, P<0.05) or QoL (r=0.685, P<0.05). Conclusions Comparison with pre-treatment, differences in IL-8, IL-10, TNF-ɑ,PGE2 and with pre-treatment, differences in IL-8, IL-10, TNF-ɑn TNF-α and

  18. The Impact of Free/Total PSA Ratio on Prostate Cancer Diagnosis in Patients with PSA Level Between 2,5-10 mg/dl Undergoing Transrectal Prostate Biopsy

    Directory of Open Access Journals (Sweden)

    Nevzat Sener

    2014-02-01

    Full Text Available Aim:  In this study, we aimed to compare the outcomes of pathologic results of patients underwent transrectal prostate biopsy (TRIB with free/total PSA ratio. Material and Method: Patients having a PSA level between 2.5-10 ng/ml and underwent TRIB were retrospectively analyzed. Patients were divided into two groups as having a free/total PSA ratio below and over 20%. The ratio below 20% was in Group 1 and over 20% were in Group 2. Results: There were 60 patients in Group 1 and 82 patients in Group 2. PSA levels were 7,45 ± 2,14 and 6,31 ± 1,89 for groups 1 and 2, respectively (p=0.067. Fourteen patients in Group 1 (23% and 15 patients in Group 2 (18% were diagnosed with prostate cancer. Sensitivity was 100% and specificity was 23% when PSA level was between 2.5 and 10. Discussion: Free/Total PSA ratio can be applied to PSA levels between 2.5 and 10. Even though it has a low specificity, with high sensitivity, it can be used in urologic practice.

  19. Complications and risk factors in transrectal prostate biopsies%经直肠前列腺穿刺活检术后并发症的原因分析

    Institute of Scientific and Technical Information of China (English)

    庄红雨; 彭涛; 许学敏

    2013-01-01

    目的 分析经直肠前列腺穿刺活检术后并发症发生的原因,提高诊治水平.方法 收集2002年1月至2012年6月北京安贞医院经直肠前列腺穿刺活检术1127例患者的病历资料进行回顾性分析.分析年龄、前列腺体积、总前列腺特异抗原(tPSA)、穿刺针数、口服抗凝药及病理结果等与并发症的关系.结果 1127例经直肠前列腺穿刺活检术患者发生并发症81例.1127例患者中,因感染中毒性休克死亡1例,发生血尿40例(3.5%),直肠出血8例(0.7%),其中5例较严重直肠出血,可于直肠镜下见直肠前壁黏膜点状缺损伴活动性出血;尿潴留21例(1.9%),发热10例(0.9%),迷走性晕厥2例(0.2%).并发症组平均年龄[(65±5)岁]高于无并发症组[(64±6)岁],差异有统计学意义(P =0.048).2组患者的平均前列腺体积、tPSA水平相近,组间差异均无统计学意义(均P>0.05).不同穿刺针数(6、8~12、>12针)及是否口服抗凝药者血尿、直肠出血、尿潴留、发热和迷走性晕厥发生率的差异均无统计学意义(均P>0.05).前列腺增生患者经直肠前列腺穿刺活检术后直肠出血发生率[0.5% (5/997)]低于前列腺癌者[2.3% (3/130)],差异有统计学意义(P=0.021);血尿、尿潴留、发热和迷走性晕厥发生率的差异无统计学意义(均P>0.05).结论 经直肠前列腺穿刺活检术是安全的,但对于高龄患者、高度怀疑前列腺癌者应警惕术后并发症的发生.%Objective To analyze the causes of the following complications after the trans-rectal prostate biopsy.Methods Transrectal prostate biopsy medical records of 1127 patients from January 2002 to June 2012 in Beijing Anzhen hospital were analyzed retrospectively,including age,prostate volume,tPSA level,biopsy needles,oral anticoagulants and pathological characters.Results 1 of 1127 patients died of septic shock.Major complications showed hematuria in 40 patients (3.5%),rectal bleeding in 8

  20. Estudio de la subestimación histológica e incidencia de falsos negativos en biopsias de mama por vacío con guía estereotáxica Evaluation of the histological underestimation and incidence of false-negative using vacuum assisted breast biopsy and stereotactic equipment

    Directory of Open Access Journals (Sweden)

    Javier Rodríguez Lucero

    2011-06-01

    Full Text Available Objetivo. Comparar los resultados histológicos en biopsias percutáneas bajo guía mamográfica y sistema de vacío con los resultados anatomopatológicos de las ulteriores cirugías. Evaluar falsos negativos al control mamográfico tras seis meses del procedimiento. Materiales y Métodos. Entre mayo de 2008 y mayo de 2010 en 148 mujeres se realizaron 157 biopsias. Del total biopsiado, se obtuvieron 137 grupos cálcicos, 6 nódulos, 9 densidades focales asimétricas y 5 blancos mixtos. Se colocaron clips en 85 blancos (85/157; 54,14%. Se compara la histología obtenida por punción con la surgida de las cirugías para analizar discrepancias o subestimaciones. En las biopsias negativas se indica control mamográfico a los 6 meses para evaluar falsos negativos. Resultados: En 41 pacientes (41/157; 27,70% se decidió completar con cirugía por el resultado histológico de la punción. Accedimos al resultado histológico quirúrgico en 34 casos, observando una concordancia entre la anatomía patológica de la punción y la quirúrgica en los 34 casos. De los 116 casos en los que no se realizó cirugía, logramos seguir mamográficamente a 67 mujeres reconociendo 1 falso negativo (1/67; 1,49% vinculado a un grupo cálcico. Conclusiones. Encontramos una correlación histológica en el 100% de los casos en los que accedimos a la anatomía patológica quirúrgica y pudimos reconocer durante el seguimiento posbiopsia 1 falso negativo. En el grupo que pudo evaluarse no hallamos subestimación. El falso negativo fue en una de las primeras pacientes biopsiadas, por lo que podría interpretarse como probable causa la falta de experiencia con el sistema. Creemos conveniente contar con grupos poblacionales más numerosos para obtener mayores conclusiones.Objective. To compare the histological findings in percutaneous biopsies under stereotactic guidance and vacuum assisted breast biopsy, with the pathological results from subsequent surgery. To evaluate false

  1. 影响二次经直肠前列腺穿刺活检阳性率的因素分析%To investigate the factors on affectting the positive prostate cancer in the secondary transrectal prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    曾健文; 蒋重和; 莫鉴锋; 周理林; 潘楚灶; 贺沂; 邵琳

    2015-01-01

    Objectives To Explore postive factors on suspicous prostate cancer in the secondary transrectal prostate biopsy.Methods From January 2008-February 2014,55 cases in our hospital had been recevied transrectal secondary prostate biopsy,retrospectively.According to the results of biopsy,the patients were divided into control groups and prostate cancer group.Differences between prostate-specific antigen(PSA) parameters and pathological findings were compared during the first puncture and to analyze the influenced factors in the second biopsy.Results There was significant difference in Family history of prostate cancer,prostate-specific antigen velocity (PSAV),prostate specific antigen density (PSAD),HGPIN,ASAP,chronic prostatitis between two groups (P < 0.05).Family history,PSAV,PSAD,HGPIN,ASAP were risk factorsn in secondary needle prostate biopsy.Results There was significant difference in Family history of prostate cancer,prostate-specific antigen velocity (PSAV),prostate specific antigen density(PSAD),HGPIN,ASAP,chronic prostatitis between two groups(P < 0.05).Family history,PSAV,PSAD,HGPIN,ASAP were risk factorsn in secondary needle prostate biopsy.Conclusions To avoid misdiagnosis and unnecessary repeat biopies,combined with the patient's family history,the first biopsy pathology results (HGPIN,ASAP) and PSAV,PSAD parameters can improve the positive rate of secondary prostate biopsy.%目的 探讨在二次经直肠前列腺穿刺活检中影响阳性率的因素.方法 回顾性分析2008年1月~2014年2月本院55例首次经直肠前列腺穿刺活检阴性并行二次经直肠前列腺穿刺活检的患者临床资料,依第二次穿刺活检结果分为前列腺癌组与非前列腺癌组.比较两组前列腺特异性抗原(PSA)相关参数及首次穿刺时病理结果的差异,并分析影响第二次穿刺活检阳性率的相关因素.结果 前列腺癌组家族史、前列腺特异性抗原速率(PSAV)、前列腺特异性抗原密度(PSAD)水平

  2. Study on infertility follicular ultrasound score from transrectal color Doppler ultrasound%腔内彩色多普勒超声对不孕症患者卵泡超声评分的研究

    Institute of Scientific and Technical Information of China (English)

    王文荣; 王艳娟; 刘瑞明; 张云; 孟凡艳

    2014-01-01

    目的:利用腔内彩色多普勒超声技术对不孕症患者卵泡监测并进行超声评分,初步探讨卵泡各种因素在不孕症范畴的相关性。方法对2011年1月至2013年12月我院超声诊断科就诊的不孕症患者腔内彩色多普勒超声所做的卵泡资料,通过卵泡大小、张力、被膜厚度、内部透声、血流情况等几个方面对卵泡进行评分并分级。结果卵泡大小界限17~25 mm计0分,14~17 mm及25~27 mm计1分,小于14 mm及大于27 mm计2分;张力分为3级,计0、1、2分;透声分为3级,计0、1、2分;被膜厚度,分为3级,小于0.5 mm,0.5~1.0 mm,大于1.0 mm计为0、1、2分;血流情况,阻力范围分为3级,计0、1、2分。结论腔内彩色多普勒超声对不孕症患者卵泡的超声评分简便易行,能够全面反映卵泡情况,给临床医生提供卵泡最全面的资料,为临床医师进一步诊治提供有力依据。%Objective To use transrectal color Doppler ultrasound in monitoring follicle infertility and ultrasound score , a preliminary study on the relationship between various factors in infertility categories of follicles.Follicular cavity data color Doppler ultrasound infertility patients .Methods On 2011 February to 2013 December in our hospital ultrasound department , by follicle size, tension, film thickness, the internal through several sound, blood flow and other aspects of scoring and grading of follicle .Results Follicle size limit of 17~25mm 0, 14 ~17mm and 25 ~27mm with 1 points, less than 14mm and greater than 27mm 2; tension was divided into 3, 0, 1, 2; sound transmission was divided into 3, 0, 1, 2; film thickness, was divided into 3 levels, less than 0.5mm, 0.5~1.0mm, more than 1.0mm is 0, 1, 2;blood flow, resistance range was divided into 3, 0, 1, 2.Conclusions Transrectal color Doppler ultrasound on follicular infertility score is simple , which can reflect the presence of follicle , follicle to

  3. Single-fraction high-dose-rate brachytherapy using real-time transrectal ultrasound based planning in combination with external beam radiotherapy for prostate cancer: dosimetrics and early clinical results

    Science.gov (United States)

    Lauche, Olivier; Delouya, Guila; Taussky, Daniel; Menard, Cynthia; Béliveau-Nadeau, Dominic; Hervieux, Yannick; Larouche, Renée

    2016-01-01

    Purpose To validate the feasibility of a single-fraction high-dose-rate brachytherapy (HDRBT) boost for prostate cancer using real-time transrectal ultrasound (TRUS) based planning. Material and methods From August 2012 to September 2015, 126 patients underwent a single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning. External beam radiation therapy (EBRT) (37.5 Gy/15 fractions, 44 Gy/22 fractions, or 45 Gy/25 fractions) was performed before (31%) or after (69%) HDRBT boost. Genito-urinary (GU) and gastro-intestinal (GI) toxicity were assessed 4 and 12 months after the end of combined treatment using the international prostate symptom score scale (IPSS) and the common terminology criteria for adverse events (CTCAE) v3.0. Results All dose-planning objectives were achieved in 90% of patients. Prostate D90 ≥ 105% and ≤ 115% was achieved in 99% of patients, prostate V150 ≤ 40% in 99%, prostate V200 < 11% in 96%, urethra D10 < 120% for 99%, urethra V125 = 0% in 100%, and rectal V75 < 1 cc in 93% of patients. Median IPSS score was 4 at baseline and did not change at 4 and 12 months after combined treatment. No patients developed ≥ grade 2 GI toxicity. With a median follow-up of 10 months, only two patients experienced biochemical failure. Among patients who didn't receive ADT, cumulative percentage of patients with PSA ≤ 1 ng/ml at 4 and 18 months was respectively 23% and 66%. Conclusions Single-fraction HDRBT boost of 15 Gy using real-time TRUS based planning achieves consistently high dosimetry quality. In combination with EBRT, toxicity outcomes appear promising. A longer follow-up is needed to assess long-term outcome and toxicities. PMID:27257413

  4. 经直肠双平面腔内超声对肛瘘及其分型的诊断价值%Biplane Transrectal Sonography Diagnosis of Fistula in Ano

    Institute of Scientific and Technical Information of China (English)

    吴长君; 吴国柱; 刘银龙; 王俊峰; 张光晨; 张锋; 汪勇

    2011-01-01

    目的 探讨应用经直肠双平面腔内超声诊断肛瘘及其分型的临床价值.方法 应用经直肠双平面腔内超声诊断79例肛痿,该组病例均经手术证实,超声诊断与术后结果 对照.结果 经直肠超声对肛瘘分型诊断符合率为92.4%,对内口的诊断符合率为92.1%,对主瘘管的诊断符合率为97.5%,对支管的诊断符合率为73.1%.结论经直肠双平面腔内超声能准确诊断肛瘘并正确分型,为临床诊断及术式的选择提供准确可靠的信息.%Objective To explore typing of anal fistula and diagnostic value of Dual plane TRUS(transrectal Ultrasonograpy)in anal fistula. Methods The sonographic features of seventy-nine patients of fistula in ano had been studied. All were treated with operation and approved by pathologic diagnosis, the ultrasonic types were classified according to the features of sonographic characteristics and the accuracy of TRUS were compared with surgical findings. Results The diagnose accordance rate of ultrasonic types was 92. 4%. The diagnose accordance rate of internal opening, primary tube and branch tube was 92.1% ,97. 5% and 73.1% respectively. Conclusions The types of anal fistula could be diagnosised exactly by Dual plane TRUS,Dual plane TRUS also could offer precise diagnostic information for the choice of the clinical treatment.

  5. 经直肠前列腺穿刺活检术后直肠活动性出血的临床分析%Reactive Proctorrhagia after Transrectal Prostate Biopsy

    Institute of Scientific and Technical Information of China (English)

    彭涛; 庄红雨; 许学敏

    2011-01-01

    目的 探讨影响经直肠前列腺穿刺活检术后直肠活动性出血并发症的相关因素,为提高诊治水平提供依据.方法 回顾性分析1 127例经直肠前列腺穿刺患者的年龄、前列腺体积、前列腺特异抗原(PSA)、穿刺活检前是否应用抗凝药、穿刺针数、病理结果.经直肠前列腺穿刺活检术后发生直肠活动性出血8例,分析活动性出血部位、程度、处理方法、治疗转归.结果 1 127例经直肠前列腺穿刺活检术后发生直肠活动性直肠出血8例,发生率为0.71%,其中997例前列腺增生患者发生直肠活动性出血5例,130例前列腺癌患者发生直肠活动性出血3例.8例直肠活动性出血患者中有2例前列腺平面以上直肠活动性出血点1个,出血量300~400 ml,直肠镜下缝扎一针止血成功;4例直肠前列腺部活动性出血点1个、2例前列腺外侧直肠活动性出血点1个,出血量100~200 ml,均在直肠镜下采用双极电凝(功率20 W)止血加肛管压迫止血成功.直肠活动性出血与直肠无活动性出血患者的年龄、前列腺体积、PSA水平比较,差异均无统计学意义(P>0.05).直肠活动性出血的影响因素分析显示,经直肠前列腺穿刺活检前是否口服抗凝药、穿刺针数均与术后直肠活动性出血无关,而患者前列腺疾病的性质与术后直肠活动性出血有关(P<0.05).结论 经直肠前列腺穿刺患者的年龄、前列腺体积、PSA、穿刺活检前是否应用抗凝药、穿刺针数与穿刺活检术后直肠活动性出血均无关,前列腺癌较前列腺增生患者易发生直肠活动性出血.正确处理术后直肠活动性出血就不会产生严重后果.%Objective To determine whether reactive proctorrhagia after transrectal prostate biopsy is affected by potential correlation factors and to improve our quality of diagnosis and treatment. Methods A total of 1 127 transrectal prostate biopsy cases were retrospectively evaluated

  6. 经直肠前列腺穿刺活检术并发感染性休克和MODS的临床研究%Clinical Analysis of Septic shock and MODS following transrectal ultrasound-guided prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    唐普贤; 王建业; 刘明; 何清; 冯喆; 韦军民

    2012-01-01

    Objective To investigate the diagnosis and treatment of septic shock and multiple organ dysfunction syndrome (MODS) following transrectal ultrasound-guided prostate biopsy (TRUSPB). Methods We reported two cases,45 and 46 years old,of septic shock and MODS after TRUSPB from June 1996 to May 2011.10 cases like these two cases in literatures were acquired (3 cases in Chinese and 7 cases in English) from 1991 to 2011,and the causes of severe infections following transrectal prostate biopsy and its prophylactic procedures were discussed as well. Results The two cases,suffered postoperative septic shock and MODS 16 -40 h after being smoothly performed TRUSPB.One patient died four days after surgery and the other improved after five days antibiotic treatment.All the 12 cases had abrupt onsets and deteriorated rapidly,2 cases died and 1 case was performed amputation due to double lower limb gangrene,resulted in high mortality and morbidity.There are many risk factors,such as repeated puncture (4/12),diabetes (3/12),chronic infections (3/12) and used immune suppression (1/12),et al; blood culture was positive in 9 case and E.coli bacteria was the main bacteria(8/9),besides,half of them were multi-drug resistant (4/8) and other 2 cases were ESBLs ( + ) or 1 case was quinolone-resistant repectively.9 cases recovered after actively controlled infection using carbapenem and other treatment. Conclusions Transrectal ultrasound-guided prostate biopsy could cause serious complications such as septic shock,to which more attentions should be paid.Preoperative use of carbapenem should be recommended for patients with repeating biopsy or other risk factors.%目的 探讨B超引导下经直肠前列腺穿刺活检术(TRUSPB)并发感染性休克和多器官功能不全综合征(MODS)的诊断与治疗. 方法 1996年6月至2011年5月行TRUSPB并发感染性休克和MODS的患者2例,年龄分别为45、46岁,回顾2例患者的诊治经过,结合1991-2011年文献报道10

  7. Role of axillary lymph node ultra-sound and large core biopsy in the preoperative assessment of patients selected for sentinel node biopsy; Ruolo dell'ecografia e della microbiopsia istologica nella valutazione del cavo ascellare in pazienti candidate a biopsia del linfonodo sentinella

    Energy Technology Data Exchange (ETDEWEB)

    Nori, Jacopo; Boeri, Cecilia; Vanzi, Ermanno; Nori Bufalini, Filippo; Masi, Andrea [Azienda Ospedaliero-Universitaria Careggi, Firenze (Italy). Diagnostica senologica; Bazzocchi, Massimo; Londero, Viviana [Udine Univ., Udine (Italy). Istituto di radiologia universitaria; Mangialavori, Giuseppe [Ospedale di Merano, Bolzano (Italy). Servizio di radiologia; Distante, Vito; Simoncini, Roberta [Firenze Univ., Firenze (Italy). Clinica chirurgica I

    2005-04-01

    important sonographic alteration was the gradual reduction in hilar echogenicity (seen in 100% metastatic nodes); conversely, hilar denting of irregularities, as well as dimensional criteria, proved to be poorly specific. Conclusions: The sonographic assessment of axillary and internal mammary chain nodes, possibly in addition to core biopsy, improve the preoperative evaluation of breast cancer patients scheduled for conservative surgery of the breast (quadrantectomy) and the axilla (sentinel node biopsy). US findings suspicious for metastatic involvement of axillary lymph nodes should be considered as an exclusion criterion for sentinel node biopsy. A more widespread use of axillary node biopsy and an accurate sonographic evaluation of the excised lymph node increase the specificity of the procedure, allowing a better correlation between sonographic findings and definitive histology. [Italian] Scopo: Valutare l'accuratezza diagnostica preoperatoria dell'esame ecografico del cavo ascellare con studio dei linfonodi, associato eventualmente a microbiopsia ecoguidata-ove esista indicazione-in pazienti con carcinoma mammario candidate a quadrantectomia associata a biopsia del linfonodo sentinella. Materiale e metodi: Nel periodo compreso tra Luglio 2001 e Dicembre 2002 presso la nostra Diagnostica Senologica abbiamo studiato con ecografia e, ove indicato, microbiopsia istologica, 117 pazienti affette da neoplasia mammaria; le lesioni avevano diametri compresi tra 4.0 e 26 mm (diametro medio 11 mm). Rispetto al totale, 15 pazienti sono state escluse: nove di queste non soddisfacevano i requisiti richiesti dalla preliminare valutazione ecografica del cavo ascellare (non erano dicumentabili linfonodi oppure erano visibili solamente due linfoghiadole) mentre le altre 6 pazienti (con citologia prechirurgica dubbia o sospetta) sono risultate, all'istologia intraoperatoria, portatrici di patologia mammaria benigna. In 11 pazienti (10.7%), in relazione al dubbio

  8. Caracterización de los tumores testiculares de células germinales según biopsias del servicio de patología. Hospital México, Costa Rica: enero 2003 a marzo 2011 Description of testicular germ cell tumors, according to biopsies from the department of pathology, Mexico Hospital, Costa Rica from january 2003 to march 2011

    Directory of Open Access Journals (Sweden)

    Julia Freer-Vargas

    2013-03-01

    Full Text Available Justificación y objetivo: el 95% de los tumores testiculares son de células germinales. La presencia de estas neoplasias ha venido en aumento, y se han hecho más frecuentes en gente jóven. Los tumores testiculares de células germinales se dividen en dos grupos: seminomatosos y no seminomatosos. El objetivo fue caracterizar los con base en los resultados de biopsia del Patología del Hospital México, del 1º de enero del 2003, al 31 de marzo del 2011. Métodos: estudio descriptivo de una base de datos del servicio de Patología, en donde se seleccionaron los tumores testiculares de células germinales. En el análisis, se calcularon frecuencias absolutas, relativas, intervalos de confianza, medidas de dispersión y de tendencia central y Chi cuadrado pBackground: 95% of testicular tumors are germ cell tumors (TGCT. These neoplasms have increased in number and have become more common in young people. The TGCTs are divided into two groups: seminomatous and non-seminomatous. The objective is to describe the TGCT based on pathological biopsy results at the Mexico hospital from 1st january 2003 to 31st march 2011. Methods: A descriptive study of the department of Pathology database, from which the cases of TGCTs were selected. Within the analysis, absolute and relative frequencies, confidence intervals, measures of dispersion and central tendency were calculated. Chi-square p <0.05 was used for the trend. Results: 148 patients with germ cell tumors were selected. There was an increasing tendency in tumors with p <0.003. Out of the total number of cases, 60.2% (89, CI 95% (52.2-68.1, occurred in males younger than thirty years old. Non-seminomatous TGCTs occurred in 59.5% (88 of the cases, CI 95% (51.5-67.3. The average age of those with non-seminoma was 26.4 years; DE 8.1, and of those with seminoma was 31 years; DE 7.5, with a difference of p <0.001. Conclusions: There is a significant tendency towards the increase of TGCT, which is more

  9. Sistema digital para realizar biopsia estereotáxica

    OpenAIRE

    Lozano Fantoba, Manuel; Ullán Comes, Miguel; Sentís i Crivillé, Melcior; Chmeissani, Mokhtar

    2007-01-01

    Referencia OEPM: P200401878 .-- Fecha de solicitud: 29/07/2004.-- Titulares: Udiat Centre Diagnostic, S.A., Institut de Fisica d'Altes Enerties (IFAE), Consejo Superior de Investigaciones Científicas (CSIC).

  10. Rectal Culture-Guided Targeted Antimicrobial Prophylaxis Reduces the Incidence of Post-Operative Infectious Complications in Men at High Risk for Infections Submitted to Transrectal Ultrasound Prostate Biopsy - Results of a Cross-Sectional Study.

    Science.gov (United States)

    Boeri, Luca; Fontana, Matteo; Gallioli, Andrea; Zanetti, Stefano Paolo; Catellani, Michele; Longo, Fabrizio; Mangiarotti, Barbara; Montanari, Emanuele

    2017-01-01

    The role of rectal culture-guided antimicrobial prophylaxis (TAP) in reducing infectious complications (IC) after transrectal-ultrasound prostate biopsy (TRUSPBx) is conflicting. We assessed the prevalence of IC in a cohort of men at high risk for IC submitted to TRUSPBx and treated with either TAP or empirical prophylaxis (EAP). Data from 53 patients at high risk for IC undergoing TRUSPBx were collected. Patients who did not receive a rectal swab (RS) were treated with EAP with fluoroquinolones (FQs). Of those who received the RS, patients with FQ-susceptible organisms received ciprofloxacin while those with FQ-resistant organisms received TAP. Office visits were scheduled to investigate the rate of complication at day 7 and 30 after TRUSPBx. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Descriptive statistics and logistic regression models detailed the association between clinical parameters and IC rate. Out of 53 men, 17 (32.1%) had RS while 36 (67.9%) did not. All RS cultures were positive for E. Coli and 4 (23.5%) reported FQ-resistant pathogens. Considering risk factors for IC, no difference was found in terms of CCI, rate of diabetes, UTIs or recent antibiotic utilization between groups. Overall, 12 (22.6%) men reported IC, with a greater proportion of them belonging to the group treated with EAP (30.6% vs 5.9%; p = 0.045). Of these, 9 (25.0%) patients, all treated with EAP, developed post biopsy UTIs. E. Coli sustained all UTIs and 7 (77.7%) were FQ resistant. At multivariable analysis, CCI≥1, a history of UTIs/prostatitis and recent antibiotic utilization (all p<0.04) were the most powerful predictors for ICs. In conclusion, we found that compared to EAP, TAP significantly reduces ICs, in men at high risk for post TRUSPBx IC. Patients at risk for IC, especially those with recent antibiotic utilization, CCI≥1 and a history of UTIs/prostatitis before biopsy, could benefit from TAP.

  11. Rectal Culture-Guided Targeted Antimicrobial Prophylaxis Reduces the Incidence of Post-Operative Infectious Complications in Men at High Risk for Infections Submitted to Transrectal Ultrasound Prostate Biopsy – Results of a Cross-Sectional Study

    Science.gov (United States)

    Boeri, Luca; Fontana, Matteo; Gallioli, Andrea; Zanetti, Stefano Paolo; Catellani, Michele; Longo, Fabrizio; Mangiarotti, Barbara; Montanari, Emanuele

    2017-01-01

    The role of rectal culture-guided antimicrobial prophylaxis (TAP) in reducing infectious complications (IC) after transrectal-ultrasound prostate biopsy (TRUSPBx) is conflicting. We assessed the prevalence of IC in a cohort of men at high risk for IC submitted to TRUSPBx and treated with either TAP or empirical prophylaxis (EAP). Data from 53 patients at high risk for IC undergoing TRUSPBx were collected. Patients who did not receive a rectal swab (RS) were treated with EAP with fluoroquinolones (FQs). Of those who received the RS, patients with FQ-susceptible organisms received ciprofloxacin while those with FQ-resistant organisms received TAP. Office visits were scheduled to investigate the rate of complication at day 7 and 30 after TRUSPBx. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Descriptive statistics and logistic regression models detailed the association between clinical parameters and IC rate. Out of 53 men, 17 (32.1%) had RS while 36 (67.9%) did not. All RS cultures were positive for E. Coli and 4 (23.5%) reported FQ-resistant pathogens. Considering risk factors for IC, no difference was found in terms of CCI, rate of diabetes, UTIs or recent antibiotic utilization between groups. Overall, 12 (22.6%) men reported IC, with a greater proportion of them belonging to the group treated with EAP (30.6% vs 5.9%; p = 0.045). Of these, 9 (25.0%) patients, all treated with EAP, developed post biopsy UTIs. E. Coli sustained all UTIs and 7 (77.7%) were FQ resistant. At multivariable analysis, CCI≥1, a history of UTIs/prostatitis and recent antibiotic utilization (all p<0.04) were the most powerful predictors for ICs. In conclusion, we found that compared to EAP, TAP significantly reduces ICs, in men at high risk for post TRUSPBx IC. Patients at risk for IC, especially those with recent antibiotic utilization, CCI≥1 and a history of UTIs/prostatitis before biopsy, could benefit from TAP. PMID:28122053

  12. EVALUACIÓN DE DOS MÉTODOS DE EXTRACCIÓN DE ADN A PARTIR DE BIOPSIAS FIJADAS EN FORMALINA Y EMBEBIDAS EN PARAFINA EN CONDICIONES NO ÓPTIMAS Evaluation of Two Methods DNA Extraction from Formalin-Fixed, Paraffin-Embedded Tissues on Non-Optimal Conditions

    Directory of Open Access Journals (Sweden)

    JAVIER ANDRÉS BUSTAMANTE

    2011-08-01

    Full Text Available Los tejidos de archivo son material de incalculable valor para estudios retrospectivos que requieran la aplicación de análisis moleculares. Existen múltiples métodos de extracción de ADN a partir de este tipo de muestras. No obstante, la mayoría de métodos toman mucho tiempo y los reactivos empleados contribuyen a la fragmentación del ADN. Con el objetivo de optimizar dos métodos de extracción de ADN a partir de tejidos embebidos en parafina en condiciones no óptimas, se seleccionaron 47 bloques en parafina que contenían biopsias de pleura, pulmón y pericardio correspondientes a 24 pacientes (66,6% hombres mayores de 18 años, con inflamación granulomatosa crónica, remitidos al Departamento de Patología, Hospital Universitario del Valle entre 2002 y 2007. Se realizaron 10 cortes a cada muestra y se sometieron a dos métodos de extracción de ADN: 1. convencional y 2. QIAamp-DNA mini kit®. La eficiencia del ADN fue valorada por espectrofotometría y amplificación del gen GAPDH. La concentración de ADN de las muestras extraídas por el método convencional fue de 65,52 ng/µL ±11,47 (promedio ± EE y la relación 260/280 varió entre 0,52 y 2,30. De las muestras extraídas por el método comercial, la concentración media de ADN fue 60,89 ng/µL ± 6,02, con una absorbancia que osciló entre 0 y 2,64. El ADN obtenido fue sometido a PCR, de 47 muestras extraídas por ambos métodos, 25 y 23 respectivamente amplificaron exitosamente el gen GAPDH. Los métodos usados para la obtención de ADN presentaron un desempeño similar, revelando así su potencial utilidad en estudios retrospectivos a partir de biopsias embebidas en parafina en condiciones inadecuadas.Paraffin wax embedded tissues are an invaluable material for retrospective studies requiring the application of molecular analysis. Multiple methods are available to extract DNA from these kind of samples. However, the most common methods are slow and the reagents often

  13. Cambios histológicos en muestras de agrandamientos gingivales obtenidas a través de biopsias con electrobisturí y bisturí convencional Histological changes in samples of gingival overgrowth biopsies obtained through conventional scalpel and electro surgical scalpel

    Directory of Open Access Journals (Sweden)

    A. Herrera Herrera

    2012-06-01

    Full Text Available Antecedentes: Es poco lo que se dice en la literatura sobre cambios histológicos observados en la encía y aun menos comparándolo en caso de agrandamiento gingival obtenido de tejidos humanos. Al realizar estos recortes surge la pregunta si existe alguna diferencia histológica al comparar las muestras obtenidas con electrobisturí y bisturí convencional. Métodos: Se implementó un estudio descriptivo comparativo, sobre 21 pacientes obteniendo 90 muestras. La asignación de los sitios quirúrgicos para cada uno de los tratamientos se hizo con la estrategia de control cruzado, evaluando ambos tratamientos en el mismo sujeto (electrobisturí y bisturí convencional, en forma aleatoria en ambas hemiarcadas. Los datos se incluyeron en una base de datos en Excel, se analizaron en un software estadístico STATA 9.1. Se utilizó el test exacto de Fischer, con significancia p=0,05. Resultados: Se observó carbonización y coagulación del colágeno en el 72,7% siendo superior en las muestras obtenidas con electrobisturí en el tejido conectivo, el 79,5% de diferencia de carbonización siendo superior con el electrobisturí en el tejido epitelial. Con respecto al bisturí convencional en el tejido conectivo en un 95,6% esta inflamación estaba mediada por linfocitos y células plasmáticas y solo en un 17,8% se encontró presencia de neutrófilos y con respecto al electrobisturí en el tejido conectivo el 100% de las muestras presentaron inflamación, el cual estaba constituido por un 97,8% de linfocitos y células plasmáticas, solo un 37,8% de neutrófilos. Conclusiones: Se observaron diversos fenómenos histológicos en las biopsias de encía obtenidas tanto con bisturí convencional como con electrobisturí que ayudan a la comprensión de las ciencias básicas para futuras investigaciones y así poder llegar a la práctica clínica. Se observaron daños en las biopsias tanto en los cortes de bisturí convencional como con los cortes de bistur

  14. Transrectal Ultrasound in Transperineal Cryosurgical Ablation for Prostate Cancer%经直肠超声在经会阴冷冻消融治疗前列腺癌中的应用

    Institute of Scientific and Technical Information of China (English)

    汪维; 郭宏骞; 李笑弓

    2012-01-01

    Objective To assess the value of transrectal ultrasound(TRUS) in transperineal cryosurgical ablation for prostate cancer. Methods The data of 34 patients diagnosed localized prostate cancer by biopsy, or with hormone-refractory prostate cancer(HRPC) were reviewed. The data of serum prostate-specific antigen(PSA)level and Gleason score were collected. The Gleason score, were 2~4, in 6 in 5~7 and 22 cases 8 -10 in 6 cases. The average pretreat-ment value of PSA was 23. 3 ng/ml(4. 7-59. 2 ng/ml). All the patients were treated with transrectal ultrasound-guided transperineal cryosurgical ablation(TRUSCSA) ,with a dual freeze-thaw cycle by using ultrathin 17-gauge cry-oneedles. Immediate and delayed morbidities were evaluated. The PSA level was obtained every 3 months for the first 2 years and then every 6 months thereafter,and failure was defined as the inability to reach a nadir of 0. 5 ng/ml or less. Results Therapeutic success was achieved in all patients. The average operative time was (105±34) min. After withdrawal of the catheter,26 cases achieved continence;8 had temporary incontinence for 3-7 days. 2 cases developed u-rethral sloughing , 1 case urethra-rectal fistula , and 1 case perineal pain. The follow-up ranged from 6 to 30 months (mean 22). The PSA level at the last follow-up visit was less than 0. 5 ng/ml in 28 patients(82%)and 0. 5 ng/ml or more in 6(18%). Conclusions The technology of TRUS is the key in transperineal cryosurgical ablation for clinically localized prostate cancer.%目的 探讨经直肠超声(TRUS)在经会阴冷冻消融治疗前列腺癌中的应用价值.方法 伴严重合并症不能接受根治性手术或拒绝开放手术、预期寿命大于10年、前列腺体积≤40 ml、或激素难治性前列腺癌(HRPC)患者34例.经直肠超声引导下前列腺穿刺活检,证实为前列腺癌,Gleason评分2~4分6例、5~7分22例、8~10分6例.血清前列腺特异抗原(PSA)平均23.3 (4.7~59.2) ng/ml.均行经直肠

  15. Hiperplasia estromal pseudoangiomatosa de la mama (PASH: presentación de dos casos Pseudoangiomatous stromal hyperplasia

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    Marta Machado

    2009-12-01

    Full Text Available La hiperplasia estromal pseudoangiomatosa (PASH es una lesión mamaria benigna infrecuente, que afecta comúnmente a mujeres premenopáusicas y que se presenta como un nódulo único, móvil, de consistencia firme y por lo general unilateral. Hay un sobrecrecimiento benigno de tejido conectivo fibroso de la mama que produce numerosos espacios que semejan estructuras vasculares. En la actualidad, la alternativa diagnóstica la provee la punción biopsia percutánea eco-dirigida o por estereotaxia, la que permite determinar la naturaleza de la lesión y descartar patología maligna, como el angiosarcoma, a fin de evitar la realización de biopsias quirúrgicas innecesarias. Presentamos dos casos que fueron categorizados en el control inicial por mamografía como BI-RADS 4c, lo que determinó la realización de una punción biopsia.Pseudoangiomatous stromal hyperplasia (PASH is a rare benign breast lesion, which commonly affects premenopausal women. It occurs as a single node, which is mobile, firm and usually unilateral. PASH is characterized by a benign overgrowth of fibrous connective tissue of the breast, which produces numerous spaces resembling vascular structures. The diagnostic alternative is currently provided by the ultrasound guided percutaneous biopsy or stereotactic biopsy, which determines the nature of the lesion and rules out malignancy, such as angiosarcoma, in order to avoid unnecessary surgical biopsies. We present two lesions that were classified as BI-RADS 4c in the initial control by mammography, which led to a needle biopsy.

  16. 超声引导下前列腺10点加定点穿刺活检术诊断前列腺癌%Transrectal ultrasound-guided 10 cores plus fixed-point prostate biopsy for diagnosing prostate cancer

    Institute of Scientific and Technical Information of China (English)

    张利; 韩雪冰; 米振国; 郭荣荣

    2008-01-01

    目的 探讨经直肠彩色多普勒超声引导下前列腺穿刺活组织检查在前列腺癌诊断中的应用.方法 181例疑诊前列腺癌的患者进行血清总前列腺特异性抗原(T-PSA)检测,采用10点加前列腺癌可疑灶定点穿刺活检术.结果 181例中检出前列腺癌80例(44.2%),前列腺增生63例(34.8%).前列腺炎36例(19.9%),前列腺结核1例(0.6%),前列腺平滑肌瘤1例(0.6%).T-PSA水平>20μg/L组的前列腺癌发生率高于其他各组.随着T-PSA水平的升高,Gleason评分增加(P<0.001).结论 超声引导下10点加定点穿刺活检术诊断前列腺癌的阳性率高,对T-PSA>20μg/L的疑诊前列腺癌患者活检意义较大.%Objective To evaluate the clinical value of transrectal ultrasound-guided 10 cores plus fixed-point prostate biopsy for diagnosing prostate cancer.Methods The serum PSA level of 181 patients were determined with ELISA.AU the patients underwent 10 cores plus fixed-point prostate biopsy under the guidance of transrectal ultrasound.Resuits 80 cases with prostate cancer(44.2%),63 cases with benign prostatic hypertrophy (34.8%),36 cases with prostatitis(19.9%),1 cage with tuberculosis(0.6%),and 1 cage with prostate leiomyoma(0.6%).When PSA WaS more than 20 μg/L,the incidence rate of prostate cancer was significantly higher than other PSA levels.Meanwhile,Gleason scores were increased with the advance of PSA levels (P<0.001).Conclusion Transrectal ultrasound-guided systematic 10 cores plus fixed-point prostate biopsy could significantly enhance the prostate cancer detection rate, and it was important in diagnosing prostate cancer for patients,especially when PsA was more than 20 μg/L.

  17. 超声引导下经直肠前列腺系统12点穿刺活检术对早期前列腺癌的诊断价值%Transrectal ultrasound- guided 12- core biopsy for early diagnosis of prostate cancer: A report of 149 cases

    Institute of Scientific and Technical Information of China (English)

    李波; 宋永胜

    2011-01-01

    目的 评价经直肠超声引导下前列腺系统12点穿刺活检术的临床价值.方法 对临床高度怀疑前列腺癌149例患者进行经直肠超声引导下前列腺系统12点穿刺活检.结果 成功进行12点系统穿刺活检者149例,获取组织满意.病理诊断为前列腺癌36例,前列腺增生80例,不典型增生4例,前列腺内皮瘤4例,前列腺慢性炎症9例,鳞状上皮化生3例,结核1例.前列腺平滑肌肉瘤7例,前列腺囊肿5例.结论 经直肠超声定位下系统12点穿刺法成功率高,无严重并发症.在临床早期诊断前列腺癌很有价值.%Objective To evaluate the clinical value of 12 - core systemic prostate biopsy. Methods Prostatic puncture and biopsy guided by transrectal ultrasound was performed in 149 patients suspected of prostate cancer. Results 149 cases were under 12 cores transrectal ultrasound guided biopsy. The histologic study confirmed 36 cases with prostate cancer, 80 benign hyperplasia, 4 atypical hyperplasia, 4 endothelioma, 9 chronic inflammation, 3 squamous cellmetaplasia, 1 tu berculosiswere, 7 leiomyosarcoma and 5 cyst of prostate. Conclusion Transrectal ultrasound guided 12 - core systemic prostate biopsy can improve prostate cancer detection rate with high success. No patient had severe complications after biopsy. It is useful in the early clinical diagnosis of prostate cancer.

  18. Punción pancreática ecodirigida: estudio multicéntrico Ultrasound-guided biopsy of the pancreas: A multicenter study

    Directory of Open Access Journals (Sweden)

    M. C. Garre Sánchez

    2007-09-01

    Full Text Available Objetivo: en el seno de la Asociación de Ecografía Digestiva se decidió realizar un estudio retrospectivo multicéntrico sobre la punción-aspiración con aguja fina (PAAF de lesiones ocupantes de espacio pancreáticas, mediante control ecográfico y por vía percutánea, con el objetivo de valorar el rendimiento de dicha técnica y poder compararla con la punción mediante ultrasonografía endoscópica. Participantes: en el estudio han participado 10 hospitales con 222 pacientes con lesiones pancreáticas entre 8 y 120 mm, sospechosas de malignidad. Resultados: el análisis de los resultados muestra una sensibilidad del 89%, especificidad 98%, valor predictivo positivo 99% y negativo 74%, con precisión diagnóstica global 91%. No encontramos ninguna complicación significativa. Conclusión: la PAAF de lesiones pancreáticas por vía percutánea es de alta rentabilidad diagnóstica y con pocas y leves complicaciones.Objective: members of "Asociación de Ecografía Digestiva" decided to carry out a multicenter retrospective study on fine-needle aspiration biopsy for pancreatic space-occupying lesions under ultrasonographic guidance and via the percutaneous route in order to assess this technique's performance versus endoscopic ultrasound-guided biopsy. Subjects: 10 hospitals for a total of 222 patients with suspiciously malignant, 8-120-mm pancreatic lesions were included in the study. Results: the analysis of results shows a sensitivity of 89%, a specificity of 98%, a positive predictive value of 99%, and a negative predictive value of 74%, for an overall diagnostic accuracy of 91%. No major complications occurred. Conclusion: percutaneous fine-needle aspiration for pancreatic lesions is highly cost-effective and has few and mild complications.

  19. Diagnosis of Polycystic Ovary Syndrome with Transrectal Ultrasound:ROC Curve Analysis%经直肠超声诊断多囊卵巢综合征ROC曲线分析

    Institute of Scientific and Technical Information of China (English)

    王海花; 李晓璇; 高蓓贝; 潘安利

    2016-01-01

    Objective To evaluate the diagnostic value of transrectal ultrasound(TRS)in poly-cystic ovary syndrome(PCOS)by using receiver operating characteristic(ROC)curve analysis, and to compare the efficacies of TRS and transvaginal ultrasound(TVS)for diagnosing PCOS. Methods Both TRS and TVS were performed in 38 healthy women and 42 patients with PCOS (NIH criteria).Ovarian volume and follicle number were determined,and ROC curves were calcu-lated.Results The ovarian volume and follicle number of PCOS are both significantly higher than control group in TRS and TVS ultrasound examination(P 9 resulted in the highest sensitivity(97.6%)and specificity(94.7%).By TVS examination,the ovarian vol-ume decision threshold≥7.85 and the follicle number decision threshold>9 were associated with the highest specificity(94.7%)and the lowest sensitivity(90.5%)for the diagnosis of PCOS. Conclusion Both TRS and TVS,especially TRS,have high diagnostic power for PCOS screening.%目的:采用 ROC 曲线分析经直肠超声(TRS)诊断多囊卵巢综合征(PCOS)的价值,并与经阴道超声(TVS)进行对比。方法38例正常女性(对照组)和42例经 NIH 标准确诊的 PCOS 患者(PCOS 组)均行 TRS 和 TVS 检查;测定卵巢体积和卵泡数目,并进行 ROC 曲线分析。结果PCOS 组 TRS 和 TVS 检测卵巢体积、卵泡数目均显著大于对照组(P <0.01)。TRS 检查卵巢体积和卵泡数目曲线下面积(AURC)分别为0.984和0.993,均高于TVS 获取的 AURC。TRS:当卵巢体积≥7.70,诊断 PCOS 特异性为84.2%、敏感性为95.2%;卵泡数目>9时,诊断 PCOS 具有最高的敏感性和特异性,分别为97.6%和94.7%。TVS:当卵巢体积≥7.85和卵泡数目>9时,诊断PCOS 具有最高的特异性(94.7%),而敏感性最低(90.5%)。结论TVS 和 TRS 对 PCOS 均具有较高的诊断效能,且 TRS 略优于 TVS。

  20. 经直肠超声诊断梗阻性无精子症致不育病因的价值%Etiology screening role of transrectal ultrasonography in male obstructive azoospermia infertility

    Institute of Scientific and Technical Information of China (English)

    宁浩杰; 韦德湛; 李红霞; 刘国庆; 徐臻; 李焕; 程超

    2015-01-01

    Objective To study etiology screening role of transrectal ultrasonography in male obstructive azoospermia infertility.Methods The clinical data of 328 cases who suspected of being obstructed sperm disease were retrospectively analyzed.TRUS detection was conducted,at the same time,the sperm amount,sperm and semen pH,pure berries quantitative,neutral sugar alpha glycosidase enzymes quantitative,elastic hard protease were tested.Results In 328 cases with male obstructed no sperm,by TRUS detection results,216 cases (65.8%) could find the causes,ejaculatory duct expansion,seminal vesicle gland lesions,prostate midline cyst were the top three causes respectively;112 patients(34.2%) had no obvious abnormal ultrasonic testing.Sperm was not seen in semen of obstructive azoospermia patients and semen pH < 7,pure berries sugar quantitative and quantitative value neutral alpha glycosidase enzymes were very low,hard elastic protease was low.Conclusion The main causes of obstructive azoospermia were ejaculatory duct expansion,seminal vesicle gland lesions,prostate midline cyst,sperm TRUS detection used for diagnosis of high sensitivity,and easy to operate,noninvasive,and combined with seminal plasma biochemical examination,the diagnostic effect is much better.%目的 探讨经直肠超声(TRUS)在梗阻性无精子症病因诊断中的价值.方法 对328例怀疑存在梗阻性无精子症患者的临床资料进行回顾性分析.对受试者行TRUS检查,同时检测受试者精液量、精子、精液pH值、精浆果糖定量、中性α-葡萄糖苷酶定量、弹性硬蛋白酶定量等指标.结果 328例男性梗阻性无精子症患者中,经TRUS检查,216例(65.8%)患者可以发现比较明确的病因,病因以射精管扩张、精囊腺病变、前列腺中线囊肿多见,分别位列病因的前三位;112例(34.2%)患者超声检查无明显异常;梗阻性无精子症患者精液中未见精子,精液pH <7,精浆果糖定量及中性α-葡萄糖苷酶

  1. Investigation on Conventional and Contrast Enhanced Transrectal Ultrasonography in Granulomatous Prostatitis%肉芽肿性前列腺炎经直肠常规超声及超声造影特征探讨

    Institute of Scientific and Technical Information of China (English)

    李岩密; 唐杰; 郭爱桃; 费翔; 张艳; 李秋洋; 何恩辉; 周昀

    2011-01-01

    Objective Granulomatous prostatitis mimics prostate cancer clinically. This study evaluated conventional transrectal ultrasound (TRUS) and contrast enhanced ultrasound (CELTS) findings of granulomatous prostatitis. Methods Thirty-seven cases of granulomatous prostatitis were culled from 2 215 consecutive men who underwent needle biopsy. Patients underwent TRUS. CEUS and histopathologic examination. Results Sonographically, 25 cases appeared solitary or multiple hypoechoic nodules in glands. Heterogeneous hypoechoic lesions with poor-defined margin in the peripheral zone were observed in 8 patients. One case presented multiple cysts and solid nodules in the gland and hypoechoic lesion involved seminal vesicles. In the remaining three patients, the gland showed a homogeneous normal echotexture. Three patients underwent CEUS. After administration of SonoVue, the lesion of one case displayed wash in simultaneously and rapidly wash out. The other two cases displayed no-enhancement areas and the boundaries were conspicuous. Conclusions It's difficult to make a specific diagnosis of granulmoatous prostatitis with nodules or differentiate it from prostate cancer only by conventional TRUS, and biopsy is still necessary. The sign of CEUS, which is no-enhancement areas, might be possible to distinguish granulmoatous prostatitis from prostate caner and very helpful in guided biopsy.%目的 肉芽肿性前列腺炎与前列腺癌难以鉴别,本研究分析肉芽肿性前列腺炎的经直肠常规超声(TRUS)和超声造影(CEUS)图像特征,以提高该病的超声诊断水平.方法 在我科行TRUS引导下前列腺穿刺活检的2 215例中经病理确诊为肉芽肿性前列腺炎者37例,分析其TRUS及CEUS特征、临床症状及病理资料.结果 TRUS示25例前列腺有单发或多发低回声结节;8例表现为周围区边界不清的低回声区;1例可见腺体内多发性囊、实性结节,病变累及精囊腺;3例常规

  2. The clinical value of using prostate volume detecting via transrectal ultrasound combine PSA level in the diagnosis for pros-tate cancer%经直肠超声检测前列腺体积结合 PSA 检测对于前列腺癌诊断的意义

    Institute of Scientific and Technical Information of China (English)

    胡剑; 任魁; 艾清秀; 王湘玉

    2015-01-01

    目的:探讨经直肠超声检测前列腺体积结合前列腺特异性抗原检测对于前列腺癌的诊断价值。方法回顾性分析我院2011年1月-2013年12月间收治的52例前列腺疾病患者的临床资料,入院后均给予经直肠超声检查,后经过前列腺穿刺活检或术后病理证实,其中有21例确诊为前列腺癌设为 PCa 组,中重度前列腺增生31例设为BPH 组,比较两组经直肠超声检测的声像特点及其 PSA 水平。结果PCa 组患者前列腺体积相比于 BPH 患者明显减小,t=3.901,P <0.05,其异常血流信号发生率明显升高,χ2=15.511,P <0.05,PCa 组患者的 PSA 值相比于 BPH组患者显著升高,t=18.470,其>10 ng/ml 区段的分布率显著高于对照组,χ2=23.862,P <0.05,<4 ng/ml 的分布率显著低于对照组,χ2=26.870,P <0.05。结论较小的前列腺体积以及异常的血流信号是前列腺癌直肠超声的检测特点,PSA 是前列腺癌的敏感性检测指标,二者联合应用于前列腺癌的诊断具有极高的临床价值。%Objective Study the clinical value of using prostate volume detecting via transrectal ultrasound combine PSA level in the diagnosis for prostate cancer.Methods Made a retrospective analysis for clinical data of 52 patients with prostate disease in our hospital from January 2011-December 2013,after hospital all of them received transrectal ultrasound detection,after the prostate biopsy or postoperative pathology,of which 21 patients was diagnosed with prostate cancer and set as PCa group,31 patients was diagnosed with moderately of severe hyperplasia and set as BPH group,compared acoustic image characteristics by transrectal ultrasound detection and the PSA level in two groups .Re-sults The prostate volume of PCa patients is lower than patients with BPH,t=3.901,P 10 is significantly higher than in the control group,χ2 =23.862,P <0.05,interval distribution

  3. 经直肠彩色多普勒超声对增生前列腺内腺低回声前列腺痛与低回声增生结节的鉴别%A study of the hypoechoic hypertrophic lesions and hypoechoic cancer lesions in hypertrophic prostate inner glands with transrectal color doppler ultrasonography

    Institute of Scientific and Technical Information of China (English)

    Hui Wang; Rui Hou; Guang Yang; Wenin Xue; Shen Lv

    2008-01-01

    Objective: To observe the sonographic and hemodynamic features of hypoechoic hypertrophic lesions and hy-poechoic cancer lesions in the hypertrophic prostate inner glands, in order to raise the accuracy of early diagnosis rate for prostate cancer. Methods: 31 cases of hypoechoic hypertrophic lesions and 18 cases of hypoechoic cancer lesions in the hypertrophic prostata inner glands were observed by transrectal ultrasonography and comparatively analyze the shape, edge and the systolic peak velocity (Vs), resistance index (RI) and pulsatility index (PI) of the lesions. Results: In contrast with hypertrophic group, the cancer group presented irregular shape and unclear edge, and obviously higher Vs, RI and PI. Con-clusion: The sonographic appearance and Vs. RI. PI have important value in distinguishing hypoechoic hypertrophic lesions and hypoechoic cancer lesions in the hypertrophic prostate inner glands.

  4. Application of transrectal ultrasound-guided transperineal prostate puncture biopsy in diagnosis of prostate cancer%基于直肠超声图像分析引导下的经会阴前列腺穿刺活检在前列腺癌诊断中应用

    Institute of Scientific and Technical Information of China (English)

    张进

    2014-01-01

    目的:探讨经直肠超声引导下经会阴前列腺穿刺活检对于前列腺癌诊断的价值。方法:通过9+X穿刺方法,对82例临床拟诊前列腺癌的患者进行经直肠超声引导下经会阴前列腺穿刺活检,对穿刺结果进行分析。结果:全部患者均活检成功,前列腺癌的阳性率为25.6%(21/82),穿刺并发症轻微。结论:经直肠超声引导下经会阴前列腺穿刺活检相对阳性率更高,并发症相对较少、较轻,适应范围更广,必将有更广阔的应用前景。%Objective:To investigate the value of the transrectal ultrasound-guided transperineal prostate puncture biopsy in diagnosis of prostate cancer. Methods:Transperineal prostate puncture biopsy was performed under tran-srectal guidance in 82 patients suspected of suffering from prostate cancer with 9+X method. Results:All the patients were completed the biopsy successfully. 21 patients were positive for cancer in 82 patients (25.6%).There were few-er and lighter complications. Conclusion:Transperineal prostate puncture biopsy would be gotten extensive usage be-cause of the higher positive rate, fewer and lighter complications and wider extent of application.

  5. 经直肠超声对前列腺苗勒管囊肿与射精管囊肿的鉴别诊断价值%Differential diagnostic value of transrectal ultrasonography for mullerian cyst and ejaculatory duct cyst

    Institute of Scientific and Technical Information of China (English)

    廖森成

    2013-01-01

    目的 探讨经直肠超声(Transrectal ultrasonography,TRUS)在苗勒管囊肿(Mullerian duct cyst,MDC)与射精管囊肿(Ejaculatory duct cyst,EDC)鉴别诊断中的价值.方法 收集TRUS所见前列腺中线囊肿70例,其中48例进行手术或超声引导下穿刺,与病理结果对照,回顾性分析其声像图特征.结果 70例病例中,苗勒管囊肿18例,射精管囊肿30例,不能明确性质22例.其中EDC伴有精囊扩张16例,射精管扩张4例,输精管扩张2例,精囊炎7例.结论 TRUS在MDC与EDC的鉴别诊断中有一定的临床价值.%Objective To investigate the differential diagnostic value of the transrectal ultrasonography (TRUS) for mullerian duct cyst (MDC) and ejaculatory duct cyst (EDC).Methods Collect 70 cases with midhne prostatic cyst diagnosed by TRUS,48 cases of which underwent surgery or ultrasound-guided puncture.Compared the TRUS results with pathological results.Retrospectively analyzed the features of TRUS.Results In the 70 patients,18 were diagnosed as mllerian duct cyst,30 ejaculatory duct cyst 30 cases and the other 22 cases properties unknown;In the cases of EDC,16 were seminal vesicle expansion,4 ejaculatory duct expansion,2 vas deferens expansion,and 9 seminal vesieulitis.Conclusion TRUS has certain clinical value in differential diagnosis of MDC and EDC.

  6. A comparative study of two histological techniques for the identification of cytomegalovirus infection in colorectal biopsies from patients with chronic inflammatory bowel disease Estudio comparativo entre dos técnicas histológicas para el diagnóstico de infección por citomegalovirus en biopsias colorrectales de pacientes con enfermedad inflamatoria intestinal crónica idiopática

    Directory of Open Access Journals (Sweden)

    M. L. de Castro

    2009-10-01

    ímica (IHC. Nuestro objetivo fue comparar la sensibilidad de ambas técnicas histológicas para establecer este diagnóstico. Pacientes y métodos: estudio caso-control, identificando en el periodo 1997-2007 aquellos pacientes CMV positivos con HE o IHQ. Sus controles fueron apareados por edad y año de diagnóstico de CMV en los casos. Se realizaron ambas técnicas en las biopsias de casos y controles obtenidas 6 meses antes y tras su inclusión en el estudio. En el análisis estadístico consideramos significativos los valores de p < 0,05. Resultados: encontramos infección por CMV en 10 pacientes. Estos sujetos presentaban más frecuentemente una EII resistente o dependiente de esteroides (p = 0,03 y un mayor número de biopsias de colon (p = 0,03. De 97 biopsias analizadas, 12 fueron HE-negativas e IHC-positivas y 3 mostraron resultados inversos. La sensibilidad de HE fue 58,6% IC95 (38,9-78,3 y para IHQ 89,7% IC95 (76,8-100. No encontramos una buena concordancia entre ambas técnicas histológicas: kappa 0,55 IC95 (0,36-0,75. La positividad para CMV se asoció al uso de más de un fármaco inmunosupresor, OR 13,5 IC95 (1,2-152,2. El tratamiento antiviral fue útil en la EII refractaria o dependiente de esteroides. Conclusiones: la IHQ posee una sensibilidad superior a HE (30% para el diagnóstico de infección por CMV en la EII, no existiendo buena concordancia entre ambas técnicas histológicas.

  7. Hemorrhagic complications and risk factors in transrectal ultrasound-guided prostate biopsies%经直肠超声引导前列腺穿刺引起出血并发症的危险因素分析

    Institute of Scientific and Technical Information of China (English)

    李岩密; 唐杰; 徐丽; 杨敬春; 张舜欣; 费翔

    2008-01-01

    目的 探讨经直肠超声(TRUS)引导前列腺穿刺的出血性并发症及其有关的可能危险因素.方法 对252例行TRUS引导前列腺穿刺活检者进行病例对照研究,对比分析穿刺后出现出血事件者和非出血组的相关因素(年龄、病理诊断、前列腺体积、高血压、糖尿病、服用抑制血小板聚集及抗凝药物、穿刺针数),采用非条件Logistic回归进行多因素分析.结果 血尿是最常见的穿刺后出血事件(19.1%).特征分析年龄和前列腺体积在两组的构成情况有差异.多因素分析出血事件具有统计学意义的相关因素包括年龄(OR=0.97,95% CI:0.942 1.000)和前列腺的体积(OR=0.989,95% CI:0.979~0.999).穿刺后血尿具有统计学意义的相关因素有3个:前列腺癌患者(OR=0.479,95% CI:0.236~0.975)、前列腺体积(OR=0.987,95% CI:0.976~0.999)、穿刺前服用抑制血小板聚集及抗凝药物者(OR=3.589,95% CI:1.133~11.366).结论 TRUS引导前列腺穿刺活检是安全、有效的.年龄和前列腺体积与出血事件的发生率有关;前列腺癌患者及前列腺体积是穿刺后出现血尿的相关因素;服用抑制血小板聚集及抗凝药物是穿刺后出现血尿的危险因素.%Objective To determine the rate of hemorrhagic complications and the possible risk factors in transrectal ultrasound(TRUS)guided prostate biopsies.Methods TRUS guided prostate biopsies were carried out in 252 patients.Chi-aquare test,t test,conditional Logistic regression were used to comparatively analyze the risk factors(age,presence of prostate cancer,the volume of prostate,arterial hypertension,diabetes mellitus,use of acetylsalicylic acid and anticoagulant,number of samples)between hemorrhagic patients and non-hemorrhagic groups.Results Hematuria was the most frequent sing in all complications,corresponding to 19.1% of the cases.According to the general feature analysis between two groups,age and the volume of the prostate were significant

  8. Comparison on transrectal ultrasonography with elastography and MR with MRS of prostate cancer%经直肠超声联合弹性成像与MR联合波谱检查诊断前列腺癌的比较分析

    Institute of Scientific and Technical Information of China (English)

    张迎春; 方军初; 马麒; 陈寒冰; 杨毅

    2011-01-01

    目的 评价经直肠超声(TRUS)联合实时弹性成像(TRTE)与MR联合MRS检查对不同Gleason评分前列腺癌( Pca)的诊断价值.方法 对73例Pca患者、49例良性前列腺增生患者(BPH组)进行TRUS联合TRTE、MR联合MRS检查,根据Gleason分级,将Pca患者分为低危组(n=21)、中危组(n=24)、高危组(n=28),以手术或穿刺活检病理组织学为标准,对检查结果进行统计分析.结果 Pca高危组的结节彩色血流最大峰值流速及阻力指数明显高于BPH组(P<0.05);中危组及高危组Pca的弹性应变率比值明显高于BPH组(P<0.05).TRUS联合TRTE的诊断符合率稍低于MRI联合MRS,但差异无统计学意义(P>0.05).结论 TRTE及MRS有助于Pca的诊断和鉴别诊断,但须密切结合TRUS及MR.%Objective To observe the diagnostic value of transrectal ultrasonography (TRUS) with transrectal real-time elastography (TRTE) and MR with MRS on prostate cancer (Pea) with different Gleason scores. Methods Totally 122 patients underwent TRUS with TRTE and MR with MRS. Seventy-three patients with Pea were divided into low risk group (n=21) , moderate risk group (n=24) and high risk group (n = 28) according to Gleason sores. The rest 49 patients were found with benign prostatic hyperplasia (PHB group). The results of each method were compared with pathological diagnosis from surgery or biopsy. Results Peak systolic velocity and resistance index of Pea in high risk group were higher than that in PHB group (F<0. 05). The strain ratio of elastography of moderate risk group and high risk group were higher than that in PHB group (P<0. 05). The diagnostic accordance rate of TRUS with TRTE was lower than that of MR with MRSt but there was no significant difference (P>0. 05). Conclusion TRTE and MRS can help to diagnosis and differential diagnosis of Pea, but need to combine with TRUS and MR.

  9. Diagnostic value of transrectal ultrasound in asexual life-history of female patients with polycystic ovary syndrome.%经直肠超声在诊断无性生活史患者多囊卵巢综合征中的价值

    Institute of Scientific and Technical Information of China (English)

    刘志辉; 邹翰琴; 颜嫒; 叶江; 刘慧; 张文波; 金秋阳; 黄俊

    2011-01-01

    目的 把经直肠超声(TRS)用于无性生活史的女性患者,探讨其在诊断多囊卵巢综合征(PCOS)中的价值.方法 对56例无性生活史的PCOS患者分别行经腹部超声检查及经直肠超声检查,仔细观察双侧卵巢并测量卵巢体积、卵泡个数、卵泡大小,比较两种检查方法的结果.结果 两种方法测量结果显示,TRS较经腹超声(TAS)卵巢显示率更高,卵巢体积两者差异无统计学意义.卵泡数量及卵泡大小两者差异有统计学意义.经TRS较经TAS更能显示小卵泡.结论 经直肠超声检查在PCOS的早期诊断中具有重要的临床意义.%Objective To investigate the clinical value of transrectal sonography (TRS) in asexual life-history of female patients with polycystic ovary syndrome (PCOS). Methods The transabdominal ultrasound and transrectal ultrasound were respectively conducted on 56 asexual life-history of female patients with PCOS. Bilateral ovarian volume, follicular number and follicular size were observed carefully and the results of two methods were compared to evaluate which was more advantage. Results Display rate of ovaries in TRS is higher than that in TAS. No significant difference was found in ovarian volume between two methods, while significant difference was observed in follicular number or follicular size between two methods. Small ovarian follicles can be shown better in TRS. Conclusion Transreetal ultrasound examination plays an important clinical significance in the early diagnosis of PCOS.

  10. 经直肠超声联合前列腺特异性抗原密度检测对前列腺癌与前列腺增生的鉴别诊断价值%Differential diagnostic value of transrectal ultrasound combined with PSAD on prostate cancer and benign prostate hyperplsia

    Institute of Scientific and Technical Information of China (English)

    罗青; 江锦雄; 曹小祯; 肖清华

    2013-01-01

    Objective To study and observe the differential diagnostic value of transrectal ultrasound combined with PSAD on early prostate cancer and benign prostate hyperplsia.Methods The clinical data of 42 patients with prostatic disorders treated in our hospital from May 2009 to June 2012 were analyzed retrospectively.All the patients received differential diagnosis of transrectal ultrasound combined with PSAD after admission.Through the examination and confirmation of prostate needle biopsy or postoperative pathology,19 patients with prostate cancer were set as PCa group and 23 patients with moderate to severe benign prostate hyperplsia were set as BPH group.The characteristics of transrectal ultrasound and test results of PSAD in 2 groups were compared.Results Prostate volume of PCa group was significantly larger than that of BPH group (P < 0.05),and the incidence rate of abnormal blood flow signal in PCa group was significantly higher than that of BPH group (P<0.05).But there was no significant difference in the incidence rate of abnormal echo tubercle between two groups(P >0.05).And PSAD value in PCa group was significantly higher than that of BPH group (P < 0.05).Section distribution rate with more than 0.2 ng/mL in PCa group was significantly higher than that of BPH group (P < 0.05),and section distribution rate with less than 0.1 ng/mL was significantly lower than that of BPH group.And there was no significant difference in section distribution rate from 0.1 ng/mL to 0.2 ng/mL between two groups(P >0.05).Conclusion Abnormal blood flow sign is the characteristic of transrectal ultrasound for prostate cancer and PSAD is a sensitive predictor of prostate cancer.The combination application of them has high differential diagnosis value on prostate cancer and benign prostate hyperplsia.%目的 探讨经直肠超声联合前列腺特异性抗原密度(PSAD)检测对早期前列腺癌与前列腺增生的鉴别诊断价值.方法 回顾性分析本院2009年5

  11. 体重指数对前列腺癌检出率及 G leaso n评分的影响%Effect of boby mass index on positive rate of prostate cancer and Gleason score in the patients undergoing transrectal prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    周峰; 浦金贤; 欧阳骏; 李纲; 平季根; 裴昌松; 黄玉华; 侯建全

    2016-01-01

    Objective To investigate the effect of body mass index (BMI) on the positive rate of prostate cancer and Gleason score in the patients undergoing transrectal prostate biopsy .Methods A total of 290 patients underwent prostatic biopsy for the first time was assigned into two groups of A(with BMI≥25 kg/m2 ,143 cases) and B(with BMI0 .05) .The percentage of patients with high Gleason score (Gleason score ≥ 7 points ) was higher in group A than that in group B (44.76% vs .38.10% ) (P0 .05);高BMI组的高Gleason评分(≥7分)比例高于正常BMI组(44.76% vs .38.10% )(P<0 .05).结论 前列腺穿刺活检患者的BM I对前列腺癌检出率没有显著影响 ,但BM I是影响前列腺穿刺活检Gleason评分的重要因素.

  12. 经直肠超声引导下的前列腺活检术后感染相关并发症的研究进展%Research Progress in Postoperative Infection Related Complications after Prostate Biopsy Guided by Transrectal Ultrasound

    Institute of Scientific and Technical Information of China (English)

    王娟霞(综述); 王志平(审校)

    2016-01-01

    With the improvement of living standards,the extension of human life,and the growth of age-ing population,the incidence of prostate cancer is an uptrend .However,there is no obvious symptom of early prostate cancer, most patients miss the best treatment timinge when diagnosed at middle-late stage,so early diagnosis of prostate cancer is critical.Prostate biopsy is the gold standard in the diagnosis of prostate cancer. Here is to make a review of the epidemiology,risk factors,prevention and treatment of the infection caused by prostate biopsy guided by transrectal ultrasound.%随着生活水平的提高、人类寿命的延长,人口老龄化增长,前列腺癌的发病率呈上升趋势。但由于前列腺癌早期无明显症状,大部分患者就诊时已属于中晚期,往往失去了最佳的治疗时机,因此早期诊断前列腺癌十分关键。前列腺穿刺活检术是诊断前列腺癌的金标准,该文对经直肠超声引导下的前列腺活检术后引发的感染相关并发症的流行病学,危险因素,预防及治疗进行综述。

  13. 经直肠三维超声检测前列腺特异性抗原相关参数诊断前列腺癌的价值%Study of prostate specific antigen relevant parameters in prostate cancer by three-dimensional transrectal ultrasonography

    Institute of Scientific and Technical Information of China (English)

    彭成忠; 范小明; 张新满; 蒋天安

    2011-01-01

    目的 探讨经直肠三维超声与血清前列腺特异性抗原(PSA)相关参数前列腺特异抗原密度(PSAD)、前列腺移行区抗原密度(PSAT)、游离前列腺特异抗原百分比和前列腺特异抗原密度的比值[(F/T)/PSAD]诊断前列腺癌的价值.方法 血清PSA位于4~20μg/L之间的患者78例,应用经直肠三维超声检测前列腺体积和移行区体积,分别计算出PSA相关参数PSAD、PSAT、(F/T)/PSAD.经直肠超声引导下前列腺穿刺活检,获得病理诊断.结果 前列腺癌组27例,前列腺增生组51例,PSAD、PSAT、(F/T)/PSAD在前列腺癌和前列腺增生组中的差异有统计学意义(P0.20、PSAT>0.33、(F/T)/PSAD0.20,PSAT>0.33,(F/T)/PSAD<0.8.Conclusions When the serum PSA level is between 4 μg/L and 20 μg/L,PSAD,PSAT and (F/T)/PSAD are of significant value to differentiate PCa from benign prostatic hyperplasia patients.The data are more reliable if prostatic volume are calculated by three-dimensional transrectal ultrasonography.

  14. Prediction of prostate cancer by logistic regression model about patient's age and transrectal ultrasound characteristics combined with serum PSA level%患者年龄及直肠超声特征联合血清PSA水平的logistic回归模型对前列腺癌的预测

    Institute of Scientific and Technical Information of China (English)

    刘琛志; 任伟

    2014-01-01

    Objective To construct a logistic regression model about the patients' age and transrectal ultrasound characteristics combined with serum PSA level and to predict prostate cancer.Methods 424 clinical data of patients with prostate disease in our hospital from January 2011 to January 2014 were retrospectively analyzed,the patients' age ,transrectal ultrasound pathological findings and biopsy findings in patients were used to establish a logistic regression model.Results Compared to patients with prostate cancer by age segment,>70 years of age or PSA levels in patients was significantly higher than in patients with other age groups;prostate cancer patients and patients with non-cancerous prostate disease were significant differences in the comparison of the various PSA levels (P0.05 );transrectal ultrasonographic combined age and PSA prostate cancer diagnosis sensitivity of 65.01% and a specificity of 92.73% and accuracy was 83.46%,81.89% positive predictive value,negative predictive value 83.95%. Conclusion Age and characteristics of patients with rectal ultrasound combined with serum PSA level logistic regression model to predict the results of the prostate is better,and should be introduced.%目的:探讨logistic回归模型的相关参数(患者年龄及直肠超声特征联合血清PSA水平)对前列腺癌的预测价值分析。方法选取2011年1月~2014年1月聊城市人民医院收治的424例前列腺疾病患者的临床资料进行回顾性分析,对患者的年龄及直肠超声检查结果与穿刺病理检查结果进行统计分析,并建立logistic回归模型。结果在前列腺癌患者分年龄段比较中,70岁以上的患者的PSA水平明显高于其他年龄段的患者(P<0.05);前列腺癌患者与非癌性前列腺疾病患者在各个PSA水平的比较中差异均有统计学意义(P<0.05);2组患者的前列腺形状、前列腺边界、内外腺边界、前列腺和精囊腺分离线的清晰度、前列

  15. Do apparent diffusion coefficient (ADC) values obtained using high b-values with a 3-T MRI correlate better than a transrectal ultrasound (TRUS)-guided biopsy with true Gleason scores obtained from radical prostatectomy specimens for patients with prostate cancer?

    Energy Technology Data Exchange (ETDEWEB)

    Kitajima, Kazuhiro, E-mail: kitajima@med.kobe-u.ac.jp [Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan); Takahashi, Satoru; Ueno, Yoshiko [Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan); Miyake, Hideaki; Fujisawa, Masato [Department of Urology, Kobe University Graduate School of Medicine, Kobe (Japan); Kawakami, Fumi [Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe (Japan); Sugimura, Kazuro [Department of Radiology, Kobe University Graduate School of Medicine, Kobe (Japan)

    2013-08-15

    Objective: To investigate the usefulness of apparent diffusion coefficient (ADC) values in predicting true Gleason scores from radical prostatectomy specimen (tGS), compared with systematic transrectal ultrasound (TRUS)-guided biopsy GS (bGS). Materials and methods: One hundred and five patients with biopsy-proven prostate cancer underwent preoperative DWI (b-values of 0, 1000, and 2000 s/mm{sup 2}) of 3-T MRI. The mean and minimum ADCs of visible tumors were calculated for either of a pair of b-values: 0 and 1000 s/mm{sup 2} (ADC{sub 1000}), or 0 and 2000 s/mm{sup 2} (ADC{sub 2000}), and relationships between the four ADC parameters and tGS evaluated for the peripheral zone (PZ) and transition zone (TZ). For multiple tumors, the dominant tumor's GS and ADCs were estimated for cancer aggressiveness assessment by computing ROC curves. Results: Significant negative correlations were observed between tGS and mean ADC{sub 1000}, mean ADC{sub 2000}, minimum ADC{sub 1000}, and minimum ADC{sub 2000} (r = −0.41, −0.39, −0.39, and −0.37, respectively) of 100 visible PZ tumors and 66 visible TZ tumors (r = −0.40, −0.42, −0.29, and −0.21, respectively). For distinguishing high-grade from low/intermediate-grade PZ lesions, the areas under the curve (AUCs) of mean ADC{sub 1000} (0.751), mean ADC{sub 2000} (0.710), minimum ADC{sub 1000} (0.768), and minimum ADC{sub 2000} (0.752) were similar to that of the highest bGS (0.708) (p = 0.61, p = 0.98, p = 0.47, and p = 0.60, respectively). For distinguishing high-grade from low/intermediate-grade TZ lesions, AUCs of mean ADC{sub 1000} (0.779), and mean ADC{sub 2000} (0.811) were similar to that of the highest bGS (0.805) (p = 0.83 and p = 0.97). Conclusion: Tumor ADCs obtained with high b-values could predict prostate cancer aggressiveness as effectively as systematic TRUS-guided biopsy.

  16. 经直肠实时超声弹性成像对前列腺增生和前列腺癌鉴别诊断的价值%The value of transrectal real-time ultrasonic elastography in the differential diagnosis between BPH and PCa

    Institute of Scientific and Technical Information of China (English)

    肖世伟; 左毅刚; 王剑松; 丁明霞; 冯蕾; 刘松

    2013-01-01

    Objective:To investigate the value of transrectal real-time ultrasonic elastography (TRTE) in the differential diagnosis between BPH and PCa,and the correlation of TRTE with Gleason scores and clinical stages.Method:Patients that were doubtful of PCa underwent a conventional TRTE check between October 2011 and September 2012 in our hospital.The results of strain ratio (SR) gained from quantitative analysis and elastic scores gained according to Ophir prostate five points-elastic scores were compared and analyzed with pathologic results and clinical stages to investigate the value of TRTE for BPH and PCa differential diagnosis.Result:The area under the Receiver Operating Characteristic curves (ROC curves) of SR max were 0.704 for differential diagnosis of BPH and PCa(95%CI 0.570-0.837,P<0.01),when a cutoff point of 16.50 was used,SR max had a sensitivity of 64.50% and a specificity 82.9% ; the area under the ROC curves of SR min were 0.723 for differential diag nosis of BPH and PCa(95%CI 0.592-0.853,P<0.01),when a cutoff point of 10.76 was used,SR min had a sensitivity of 61.30% and a specificity 85.7% ; when a cutoff point of 3 was used,elastic score had a sensitivity of 83.90% and a specificity of 65.70%.SR max has a low positive correlation with.Gleason scores (r=0.322,P=0.038); SR min has a moderately positive correlation with Gleason scores (r=0.413,P=0.021); SR max and SR min has no significant statistically significant correlation with clinical stages(r=-0.114,P =0.543; r=-0.060,P=0.748).Elastic score has a moderately positive correlation with Gleason scores and clinical stages respectively(r=0.450,P=0.011; r=0.595,P<0.001).Conclusion:TRTE is valuahle for differential diagnosis of BPH and PCa,and it has a certain degree of correlation with Gleason scores and clinical stages.%目的:探讨经直肠实时超声弹性成像(transrectal real-time ultrasonic elastography,TRTE)对前列腺增生(BPH)和前列腺癌(PCa)鉴别诊断的价值

  17. Comparison of diffusion weighted imaging and transrectal ultrasound-guided biopsy in predicting aggressiveness of prostate cancer%比较MR扩散加权成像和经直肠超声引导穿刺Gleason评分评估前列腺癌侵袭性的差异

    Institute of Scientific and Technical Information of China (English)

    李春媚; 陈敏; 李飒英; 张晨; 王萱; 周诚

    2012-01-01

    目的 比较DWI ADC值和经直肠超声引导穿刺所得Gleason评分评估前列腺癌侵袭性的作用.方法 回顾性分析51例经穿刺活检确诊为前列腺癌,于1.5 TMR扫描仪上行前列腺DWI检查,并进行了前列腺癌根治术的患者资料.以前列腺癌根治术标本为参考,测量前列腺癌灶的ADC值,采用Pearson相关分析检验癌灶ADC值与前列腺癌根治术标本Gleason评分的相关性,以及穿刺活检所得Gleason评分与前列腺癌根治术标本Gleason评分的相关性,采用ROC曲线分析确定癌灶ADC值和穿刺活检所得Gleason评分区分前列腺低级别癌和中高级别癌的效能.结果 前列腺穿刺活检评估前列腺癌根治术标本Gleason评分的准确率为41.2% (21/51),11.8% (6/51)患者Gleason评分被高估,47.0% (24/51)患者GS被低估.51例患者前列腺癌灶的ADC值平均为(0.974±0.194)×10-3 mm2/s,35例中高级别前列腺癌平均ADC值为(0.907±0.160)×10-3 mm2/s,16例低级别前列腺癌平均ADC值为(1.121±0.185)×10-3 mm2/s.前列腺癌灶ADC值与前列腺癌根治术标本Gleason评分存在负相关性(r=-0.761,P<0.01),而穿刺活检所得Gleason评分与前列腺癌根治术标本Gleason评分不存在相关性(r=0.187,P=0.189).ADC值和穿刺活检所得Gleason 评分区分前列腺低级别癌和中高级别癌的ROC曲线下面积分别为0.827和0.689.结论 前列腺癌灶的ADC值预测前列腺癌侵袭性优于穿刺活检所得Gleason评分.%Objective To retrospectively evaluate the utility of apparent diffusion coefficient (ADC) values in predicting aggressiveness of prostate cancer.Comparison was made with transrectal ultrasound-guided biopsy Gleason scores (GS) and prostatectomy GS.Methods Diffusion weighted images of 51 patients with biopsy-proven prostate cancer were obtained using 1.5 T MR with a pelvic phased-array coil.Regions of interest (ROIs) were drawn on areas of the suspicious lesion and the ADC values were calculated

  18. Application of microvascular density in determination of transrectal ultrasound hemodgynamics in differential diagnosis of prostate cancer and chronic prostatitis%微血管密度在经直肠超声血流动力学检测鉴别诊断前列腺癌和慢性前列腺炎中的应用及其评价

    Institute of Scientific and Technical Information of China (English)

    卢凤迎; 廖新红; 李智贤; 高泳; 李天宇

    2014-01-01

    Objective To study the application value of microvascular density (MVD)in determination of transrectal ultrasound hemodgynamics in the differential diagnosis of prostate cancer and chronic prostatitis, and to provide imageological basis for their differential diagnosis.Methods A total of 6 1 patients suspected of prostate cancer underwent transrectal ultrasound scan and ultrasound guided biopsy.38 cases of prostate cancer and 23 cases of chronic prostatitis were confirmed by pathology and retrospectively analyzed.The peak systolic blood flow velocity (Vs)and blood flow classification of the suspicious lesions were compared and analyzed.The MVD was observed by Weidner method with monoclonal antibody CD34 immunohisochemistry staning. Results The Vs and the blood flow classification of the suspicious lesions in prostate cancer group were significant higher than those in chronic prostatitis group (P<0.05).The MVD in prostate cancer group and chronic prostatitis group were 46.70±13.87 and 34.38±7.28,respectively(P<0.05);the MVD in prostate cancer (C+D)stage and (A+B)stage were 56.99±12.85 and 39.97±10.21,respectively(P<0.05);the MVD in prostate cancer with high Gleason score group and low Gleason score group were 53.79±13.30 and 36.96±7.24,respectively(P<0.05).The Vs and the blood flow classification of the suspicious lesions of prostate cancer had a significantly positive correlation with the MVD (r=0.793,P<0.05;r=0.723,P<0.05).Conclusion The Vs and the blood flow classification of prostate cancer by ultrasound can well reflect the changes of the micrangium in tumor tissue. The Vs and blood supply grade of suspicious lesions in the patients with prostate cancer are significantly higher than those in the patients with chronic prostatitis.They may be useful for the identification of prostate cancer and chronic prostatitis.%目的:探讨微血管密度(MVD)在经直肠超声血流动力学检测鉴别诊断前列腺癌和慢性前列腺炎中的应用价值

  19. The significance of transrectal ultrasound guided transperineal seminal vesicle biopsy in evaluating the clinical stage of prostate cancer%直肠超声引导下经会阴精囊腺穿刺活检术在评价前列腺癌临床分期中的意义

    Institute of Scientific and Technical Information of China (English)

    卢圣铭; 丁雪飞; 肖芹; 周广臣; 顾晓; 齐小康; 陈骥

    2015-01-01

    目的 探讨直肠超声引导下经会阴精囊腺穿刺活检术在评价前列腺癌临床分期中的可行性和安全性.方法 回顾性分析2010年7月至2015年1月收治的57例伴有精囊异常的疑似前列腺癌患者的临床资料.年龄50 ~ 78岁,平均(65±7)岁.血清总前列腺特异性抗原(tPSA)3.2 ~ 131.1 μg/L,平均(23.7±11.3) μg/L.22例直肠指检可触及前列腺结节.结合MRI检查结果,临床分期均为T3b期.局麻下,57例均行超声及模板引导下经会阴前列腺及精囊腺分区穿刺活检,前列腺分为11区,每区穿刺1~4针;两侧精囊腺分别自外侧向中央穿刺3针,尽量靠近膀胱底部.穿刺组织送病理检查.结果 57例均顺利完成穿刺.穿刺病理检查发现前列腺癌44例,Gleason评分6~10分.其中累及精囊腺32例(阳性组),肿瘤分期T3b期;未累及12例(阴性组),肿瘤分期T2期.阳性组中20例行根治性前列腺切除术,术后病理诊断均提示前列腺癌累及精囊腺,术后病理分期为T3b期.阴性组中11例行根治性前列腺切除术,2例术后病理诊断提示累及精囊腺,肿瘤分期为T3b期.精囊腺穿刺敏感性为91% (20/22),特异性为100% (9/9),阳性预测值为100%(20/20),阴性预测值为82% (9/11).57例穿刺后均无发热,发生肉眼血尿23例(40%)、血精20例(35%)、尿潴留1例(2%),对症处理后症状消失.结论 直肠超声引导下经会阴精囊腺穿刺安全、可靠,有助于提高前列腺癌术前临床分期的准确率.%Objective To explore the safty and feasibility of transrectal ultrasound guided transperineal seminal vesicle biopsy in the evaluation of clinical staging of prostate cancer.Methods Retrospectively study 57 suspected prostate cancer patients with seminal abnormality during 2010.7-2015.1,age ranged from 50 to 78 years,average 65 ±7 years,serum total prostate specific antigen (tPSA) 3.2-131.1 μg/L, average (23.7 ± 11.3) μg/L.Twenty-two cases had palpable prostate

  20. Biopsym : a learning environment for transrectal ultrasound guided prostate biopsies

    CERN Document Server

    Thomas, Janssoone; Vadcard, Lucile; Mozer, Pierre; Troccaz, Jocelyne

    2010-01-01

    This paper describes a learning environment for image-guided prostate biopsies in cancer diagnosis; it is based on an ultrasound probe simulator virtually exploring real datasets obtained from patients. The aim is to make the training of young physicians easier and faster with a tool that combines lectures, biopsy simulations and recommended exercises to master this medical gesture. It will particularly help acquiring the three-dimensional representation of the prostate needed for practicing biopsy sequences. The simulator uses a haptic feedback to compute the position of the virtual probe from three-dimensional (3D) ultrasound recorded data. This paper presents the current version of this learning environment.

  1. Dual-Modality Prostate Imaging with PET and Transrectal Ultrasound

    Science.gov (United States)

    2009-04-01

    Z(>>(*B(Z( JDL (*BD(6?&(’&::#90*#:#$&N(R&:8"<%(*’:<%N&$( ?8@(8(L(*B(NɠB&"&$D(\\=](V&*#%@"$Q*"&N(*#$#%8:(4S6(<B8R&(#M("?&(4S60Q:"$8@#Q%N(A?8%"#BD(6...8[Q80*#:#$&N( $&*Ŝ%RQ:8$(A&:F<@(?8@(#Q"&$(N<B&%@<#%@(#M(>G(*B(Z(>>(*B(Z( JDL (*BD(6?&(N8$+(R$&&%0*#:#$&N( *’:<%N$<*8:(A$#@Ŝ"&(?8@(8(L(*B(NɠB&"&$(8%N

  2. Antibiotic prophylaxis for transrectal prostate biopsy-a new strategy

    DEFF Research Database (Denmark)

    Antsupova, Valeria; Nørgaard, Nis; Bisbjerg, Rasmus;

    2014-01-01

    with pivmecillinam and amoxicillin/clavulanic acid before and for 2 days after TRUBP. RESULTS: One hundred and ten out of 148 (74.3%) post-TRUBP infections were caused by Escherichia coli, Klebsiella pneumoniae or Enterococcus faecalis. Group 3 with the extended prophylaxis with pivmecillinam and amoxicillin...

  3. Feasibility of Prostate Cancer Diagnosis by Transrectal Photoacoustic Imaging

    Science.gov (United States)

    2014-05-01

    neoplasia (PIN) and then become adenocarcinoma [32] with increased hyperplastic epithelium or/and cellular tufts filling the glandular space [33]. In...suggested that as the PCa grade of tissue increases from low to high, glandular epithelial cells will progress toward prostatic intraepithelial...foci of adjacent carcinoma, and thus changes cellular architecture and composition in both glandular and stroma space [33]. All of these

  4. 经直肠超声引导精囊穿刺注射药物冲洗治疗精囊炎的研究%Study on Puncturing Seminal Vesicle and Injecting Drugs Under the Guidance of Transrectal Ultrasound to Treat Vesiculitis

    Institute of Scientific and Technical Information of China (English)

    黄进; 李文伦; 张明荣; 张华民; 付世文; 李莉

    2001-01-01

    目的:探讨经直肠超声(TRUS)引导精囊穿刺注射药物冲洗并保留治疗精囊炎的效果。方法:将76例患者随机分为A、B、C三组,A组28例在TRUS引导下穿刺精囊,用灭滴灵250ml冲洗精囊后,注入丁胺卡那霉素0.4g保留;B组28例在TRUS引导下穿刺精囊,用生理盐水250ml冲洗精囊,注入丁胺卡那霉素0.4g保留,两组均每隔10天治疗一次,3次为一疗程;C组20例口服氟嗪酸及静脉应用丁胺卡那霉素。对三组的疗效进行评价。结果:A组治愈25例(89.3%),有效2例(7.1%),无效1例(3.6%),总有效率96.4%,B组治愈16例(57.1%),有效6例(21.4%),无效6例(21.4%),两组穿刺成功率100%。C组治愈3例(15%),有效3例(15%),无效14例(70%),A、B组比较治愈率、有效率有明显差异P<0.01,A、C两组比较有显著差异P<0.001。结论:TRUS引导精囊穿刺注射药物冲洗并保留抗生素治疗精囊炎是一种理想的治疗方法。%Objective:To explore the ideal result of puncturing seminalvesicle and injecting drugs with sluicing and retaining ways under the guidance of transrectal ultrasound(TRUS) to treat vesiculitis.Methods:Seventy six cases with vesiculitis were randomly divided into A,B,C groups. In group A 28 cases with seminal vesicles were punctured under the guidance of TRUS,sluiced with metronidazole,injected and retained with amikacin 0.4g. In group B other 28 cases with seminal vesicles were punctured with the same method, but sluiced with 0.9% NS, injected and retained with amikacin 0.4g.Each one of A,B groups were treated this way once in ten days.One course consisted of three times. In Group C 20 cases with seminal vesicle were treated with Ofloxacin capsules P.O. and amikacin in intravenous drip.Results:Twenty five cases of group A were cured(89.3%),the alleviations rate was 7.1%(2),one case was ineffective(3.6%),the total effective rate was 96.4%.sixteen cases in group B were cured(57.1%),the

  5. 经直肠超声检查在男性梗阻性无精子症病因筛查中的作用(附695例病例分析)%Transrectal ultrasonography in the etiological diagnosis of male obstructive azoospermia:Analysis of 695 cases

    Institute of Scientific and Technical Information of China (English)

    王道虎; 陈凌武; 丘少鹏; 邓春华; 梁辉; 赵红伟; 吴荣佩; 陈炜; 陈羽; 罗俊航; 陈俊星; 梁月有

    2011-01-01

    Objective: To assess the role of transrectal ultrasonography (TRUS) in the etiological diagnosis of male obstructive azoospermia. Methods: We retrospectively analyzed the clinical data and TRUS findings of 695 patients with obstructive azoospemia from January 2007 to May 2009. Results: Concerning the etiology of obstructive azoospemia, the main TRUS findings included ejaculatory duct abnormality (29.2%), seminal vesicle abnormality (25.4%) and prostate midline cyst ( 18.5% ). TRUS revealed 203 cases of ejaculatory duct dilation, 177 cases of seminal vesicle abnormality (including 108 with absence or agenesis and 51 with dilation of the seminal vesicle), and 128 cases of prostate midline cyst ( including 75 with ejaculatory duct cyst and 39 with Miillerian cyst). Calcification of the verumontanum or ejaculatory duct was suspected to be the causes of obstructive azoospermia in 34 cases.However, no significant etiological abnormality was found in 153 cases. Obvious etiology was shown by TRUS in 78.0% of the patients. Conclusion: TRUS can clearly display the structural abnormality of the ejaculatory duct and seminal vesicle, and provide important information on the etiology of male obstructive azoospermia.%目的:探讨经直肠超声(THUS)在男性梗阻性无精子症病因筛查中的作用.方法:回顾性分析我院2007年1月至2009年5月695例男性梗阻性无精于症患者的TRUS的病因诊断结果.结果:695例梗阻性无精子症患者中,TRUS检查发现病变以射精管病变(29.2%)、精囊腺病变(25.4%)以及前列腺中线囊肿病变(18.5%)为主.TRUS检查共发现射精管扩张203例;精囊腺病变177例,其中先天性精囊腺缺如或者发育不全108例,精囊腺扩张51例;另外,TRUS诊断发现前列腺中线囊肿128例,其中75例(58.5%)射精管囊肿,39例(30.5%)苗勒管囊肿.34例患者的梗阻性无精于症可能由于钙化性疾病导致.而153例患者(22.0%)TRUS检查未见明显异常.TRUS在本组

  6. Características de las úlceras gastroduodenales en pacientes con biopsia negativa para Helicobacter pylori.

    OpenAIRE

    Montes Teves, Pedro; Salazar Ventura, Sonia; Monge Salgado, Eduardo

    2014-01-01

    Objetivo. Evaluar las características clínico-epidemiológicas de la enfermedad ulcerosa péptica no asociada a infección por Helicobacter pylori (Hp). Métodos. En este estudio de corte transversal se incluyeron 651 pacientes con diagnóstico de úlcera péptica atendidos durante el período enero 2000 - diciembre 2005. El diagnóstico de infección por Hp se realizó mediante histología. Se compararon las características clínicoepidemiológicas y endoscópicas de los pacientes c...

  7. Biopsia por cepillado con el OralCDx®: Estado de la cuestión

    Directory of Open Access Journals (Sweden)

    R. Matos Cruz

    2013-06-01

    Full Text Available La controversia en torno al OralCDx® (OralScan Laboratories Inc., Suffern, Nueva York se ha mantenido desde la publicación del primer estudio evaluando la validez y seguridad de esta prueba diagnóstica, como artículo de portada de la revista JADA en 1999. Aunque el estudio fue muy elogiado por algunos, otros han cuestionado la interpretación de la estadística y por consiguiente la aplicabilidad clínica de estos resultados. Esto dio lugar a lo que Greenberg designó la "controversia del cepillo" y a una incertidumbre, que aún hoy prevalece, en cuanto al uso de esta prueba diagnóstica. Entendemos que es importante llevar a cabo un análisis actualizado de la literatura que permita resumir la evidencia actual en torno al OralCDx®. El objetivo de este artículo es realizar una revisión bibliográfica relacionada con la precisión del sistema de Test de cepillado OralCDx® como técnica adyuvante de diagnóstico de LOMP. Se resumen datos acerca del diseño, muestras y características del grupo de estudio, intervenciones, resultados comunicados y medidas básicas de precisión diagnóstica de este método adyuvante, a partir de los estudios clínicos publicados entre los años de 1999 y 2013.

  8. Tumores primarios intracranianos: analise de uma serie de autopsias e biopsias consecutivas

    OpenAIRE

    Marco Aurelio Lana-Peixoto; Jose Eymard Homem Pittella; Eustaquio Martins Gomes Arouca

    1981-01-01

    Entre 19.760 autópsias e 72.972 biópsias consecutivas, num período de 41 anos e 4 meses, foram encontrados 294 tumores intracranianos primários representando 74,8% das lesões expansivas intracranianas. Cerca de dois terços destes tumores se localizavam no compartimento supratentorial. Os gliomas foram os tumores mais freqüentemente observados, seguidos pelos meningiomas, adenomas hipofisários, tumores de origem embrionária e tumores vasculares. Na região selar foram diagnosticados 39 tumores,...

  9. Tumores primarios intracranianos: analise de uma serie de autopsias e biopsias consecutivas

    Directory of Open Access Journals (Sweden)

    Marco Aurelio Lana-Peixoto

    1981-03-01

    Full Text Available Entre 19.760 autópsias e 72.972 biópsias consecutivas, num período de 41 anos e 4 meses, foram encontrados 294 tumores intracranianos primários representando 74,8% das lesões expansivas intracranianas. Cerca de dois terços destes tumores se localizavam no compartimento supratentorial. Os gliomas foram os tumores mais freqüentemente observados, seguidos pelos meningiomas, adenomas hipofisários, tumores de origem embrionária e tumores vasculares. Na região selar foram diagnosticados 39 tumores, incluindo os tumores intra-selares, supraselares e paraselares. A maior parte destes tumores foi constituída pelos adenomas hipofisários, seguidos pelos craniofaringiomas, meningiomas, cistos epidermóides e teratomas. Setenta e cinco tumores foram verificados em pacientes com idade inferior a 15 anos, sendo a maioria deles na fossa posterior, principalmente no cerebelo. Estes tumores foram representados pelos astrocitomas do cerebelo e tronco encefálico, meduloblastomas e ependimomas do quarto ventrículo. Os dados obtidos foram comparados com as várias séries encontradas na literatura.

  10. Diagnosis of Helicobacter pylori infection using urease rapid test in patients with bleeding duodenal ulcer: influence of endoscopic signs and simultaneous corporal and antral biopsies Diagnóstico de la infección por Helicobacter pylori mediante el test rápido de la ureasa en pacientes con hemorragia por úlcera duodenal: influencia de los signos endoscópicos de sangrado y de la obtención simultánea de biopsias de cuerpo y antro gástrico

    Directory of Open Access Journals (Sweden)

    M. Castro Fernández

    2004-09-01

    patients with combined antral and fundic biopsies. In group A, urease test was positive in 90.5% of patients; in group B, it was positive in 89.5% of patients, and in group C, the test turned positive in 75.4% of patients. Statistical differences were only reached when patients in group C were compared to patients in groups A and B together (p = 0.037. Conclusions: 1. The presence of either blood in the stomach or recent bleeding endoscopic signs appeared not to be the conditioning factor for the decreased sensitivity of urease test among patients with bleeding duodenal ulcer. 2. The decreased sensitivity of this test in patients with upper gastrointestinal bleeding is more evident during the resolution stage, and it does not seem to occur because of H. pylori migration from the antrum to the corporal gastric region.Introducción: la sensibilidad de los métodos diagnósticos invasivos de infección por H. pylori, especialmente el test rápido de la ureasa, disminuye en los casos de úlcera gastro-duodenal y hemorragia digestiva. Objetivos: valorar la influencia de la presencia de sangre en estómago o de signos endoscópicos de sangrado en la sensibilidad del test rápido de la ureasa en pacientes con hemorragia por úlcera duodenal, así como la influencia de la obtención de biopsias de cuerpo y antro gástrico. Pacientes y métodos: incluimos 120 pacientes, 85 varones y 35 mujeres, con edad media de 62 (18-88 años, con hemorragia por úlcera duodenal y diagnóstico endoscópico en las primeras 24 horas del ingreso. Ningún paciente había consumido antiinflamatorios no esteroideos, inhibidores de la bomba de protones o antibióticos en las dos semanas previas a la hemorragia digestiva, ni había recibido tratamiento frente a H. pylori. En este grupo seleccionado de pacientes admitimos una tasa de infección de prácticamente el 100%. Investigamos la infección por H. pylori mediante biopsias de antro (69 casos o de cuerpo y antro (51 casos gástricos para test de

  11. 老年男性前列腺特异抗原水平与直肠超声引导无痛前列腺穿刺结果的相关性分析%Relation of the prostate specific antigen level with the outcome of analgesic transrectal ultrasound-guided prostate biopsy by intravenous anesthesia in the older men

    Institute of Scientific and Technical Information of China (English)

    王振华; 魏金星; 张雪培

    2011-01-01

    Objective To investigate the relation of the prostate specific antigen (PSA) level with the outcome of analgesic transrectal ultrasound-guided prostate biopsy(ATUGPB) by intravenous anesthesia and clinical parameters in the older men with evaluated PSA. Methods The AUGPB with twelve cores by intravenous anesthesia were completed in 106 patients from September 2008 to August 2010 induding our outpatient and inpatient [mean age(68±7)years] with evaluated PSA(>4 ng/ml). According to the PSA level, the patients were divided into low-risk group(4 ng/ml20 ng/ml,24 cases). The parameters were recorded including biopsy time, visual analog pain scale score(VAS), prostate volume(PV), PSA density(PSAD), pathological outcome, anesthetic adverse events and complications. Results The mean biopsy time was(5.9±2.0)min, ninety eight cases(92%) had no pain(VAS=0)and no case occurred anesthetic adverse event. There were total 164 positive cores in 1272 cores, of which 36 cases were prostate cancer(Pca), 4 cases were prostate atypical hyperplasia and 4 cases were prostate intraepithelial neoplasia. The detection rate of Pca from low-risk group to high-risk group were respectively 10.9%, 33.3% and 87.5%, and that of benign prostatic hyperplasia(BPH) were 81.8%, 59.2% and 4.2%, the difference of them was significant(P4 ng/ml),平均年龄(68±7)岁,进行静脉麻醉下经直肠超声引导无痛前列腺12针系统首次穿刺.将PSA水平分为低危组(4 ng/ml20 ng/ml,24例).记录穿刺时间、视觉模拟疼痛评分(VAS)、PSA密度(PSAD)、前列腺体积(PV)、穿刺病理结果、麻醉不良事件.结果 平均穿刺时间(5.9±2.0)min,98例(92%)穿刺后无疼痛(VAS=0),无一例发生麻醉不良事件.共穿刺1272针,病理阳性164针,包括36例前列腺癌(Pca)、4例非典型增生、4例腺瘤样改变.低危、中危和高危组中Pca检出率分别为10.9%、33.3%和87.5%,良性前列腺增生(BPH)检出率分别为81.8%、59.2%和4.2%,

  12. 前列腺周围神经阻滞麻醉对缓解经直肠超声引导下前列腺穿刺活检术疼痛的效果%Efficacy of periprostatic nerve block anesthesia for pain control in transrectal ultrasound-guided systematic prostate biopsy

    Institute of Scientific and Technical Information of China (English)

    谢毅; 周芳坚; 李永红; 蒋丽娟; 吴志明; 秦自科; 韩辉; 刘卓炜

    2016-01-01

    目的:评估前列腺周围神经阻滞麻醉(PPNB)对缓解经直肠超声引导下前列腺穿刺活检术时疼痛的效果。方法回顾性分析我院2013年11月~2015年1月经直肠超声引导下前列腺12针系统穿刺患者111例,根据是否采用PPNB,将患者分成PPNB组(52例)和非PPNB组(59例)。PPNB组在经直肠超声引导下注射1%利多卡因阻滞麻醉前列腺周围神经,然后行穿刺活检;非PPNB组未采用任何麻醉方法。穿刺结束后采用视觉模拟评分法对直肠指检(DRE)、经直肠超声检查、穿刺过程进行疼痛评分;穿刺结束后7天随访患者穿刺并发症。结果两组患者的年龄、前列腺体积、总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)、DRE异常比例差异无统计学意义。两组患者DRE疼痛评分(1.40∶1.39,P=0.997)、经直肠超声检查疼痛评分(2.10∶2.07,P=0.834)差异无统计学意义;然而,PPNB组穿刺疼痛评分更低(2.54∶3.07,P=0.033)。两组患者穿刺并发症差异无统计学意义。结论相对于无麻醉,采用前列腺周围神经阻滞麻醉可减轻经直肠超声引导下前列腺穿刺活检术时疼痛不适。%Objective To evaluate the efficacy of periprostatic nerve block anesthesia (PPNB) for pain relief in transrectal ultrasound-guided systematic prostate biopsy (PBx). Methods We reviewed the data of patients undergoing initial PBx at our center from November, 2013 to January, 2015. Only the patients with 12-core systemic PBx were included and 111 patients were eligible for this study, among whom 52 patients received PPNB and 59 did not. PPNB was achieved by an injection of 5 mL of 1%lidocaine at the angle between the seminal vesicle and base of the prostate on each side before biopsy. The DRE pain score, probe insert pain score, and biopsy pain score were assessed by visual analogue scale (VAS) immediately after the biopsy. The complications

  13. Evaluation on Transrectal Ultrasound in Identification of Benign and Malignant Hypoechoic Lesions in Prostate Peripheral Zone%经直肠超声鉴别前列腺外周区低回声良、恶性病变的价值

    Institute of Scientific and Technical Information of China (English)

    凌冰; 王小燕; 蓝春勇; 康利克; 廖明珠; 农美芬

    2014-01-01

    Objective To evaluate transrectal ultrasound ( TRUS) in the identification of benign and malignant hypoechoic lesions in the prostate peripheral zone .Methods The data of 74 cases of hypoechoic lesions in the prostate peripheral zone confirmed by TRUS were analyzed retrospectively .All patients underwent ‘6 +X ’ prostate biopsy guided by TRUS .The analysis on the distribution differences between benign and malignant lesions in the different morphological characteristics as well as the morphological characteristics of hypoechoic lesions was conducted .The positive rates of different hypoechoic lesions biopsies were calculated .Results ①Of the 74 lesions,30 benign lesions and 44 malignant lesions,the detection rate of prostate cancer was 59.5%(44/74).②The malignant lesions were dominated by mass(38.64%) and girdle-shaped ( 45.45%) lesions.The benign lesions were dominated by small-nodositied lesions (57.15%).There were significant differences (P<0.05).③The positive rates of targeted biopsy for mass ,girdle-shaped lesions were 89.5%(17/19),69.0%(20/29),respectively,which were significantly higher than that (26.9%,7/26) of small-nodositied lesions(P<0.05).④The specificity of combining mass with girdle-shaped lesions as a sonographic characteristic for the diagnosis of prostate cancer was 70 .8%,the positive predictive value was 84 .1%.Conclusion The mass and girdle-shaped hypoechoic lesions in the prostate peripheral zone could be regarded as ‘hot spot ’ of targeted biopsy .The combination of above two forms applied to the diagnosis of prostate cancer could improve the specificity of TRUS.%目的:探讨经直肠超声( TRUS)鉴别前列腺外周区低回声良恶性病变的价值。方法回顾性分析74例在TRUS检查发现前列腺外周区低回声并在超声引导下行“6+X”前列腺穿刺活检的病例资料,分析低回声病变的形态特点,良恶性病变在不同形态特征的分布特点,计算不同形态低回声

  14. Prophylactic using of levofloxacin in transrectal prostate biopsy: a prospective, multicenter, randomized, effective drug control and open-label clinical study%左氧氟沙星在经直肠前列腺穿刺围手术期应用的多中心、随机、对照、开放临床研究

    Institute of Scientific and Technical Information of China (English)

    乔庐东; 陈山; 王晓峰; 李清; 杨为民; 牛远杰; 孔垂泽; 王毅; 唐伟

    2014-01-01

    Objective To find an efficacy,safety and economic prophylactic regimen after the transrectal ultrasound-guided prostate biopsy (TRUSPBs) by comparing the results of infection complications after the oral levofloxacin application with other intravenous prophylaxis antibiotics.Methods It was a prospective,randomized,multicenter,effective drug control and open-label clinical study.From October 2011to December 2012,296 patients who had indications of prostate biopsy in 8 medical centers were randomized into two groups:test group (n=150,levofloxacin,500 mg,po,qd for 3 days) and control group (n=146 intravenous antibiotics of any kinds,3 days).All those antibiotics were used on the day of biopsy and within two days after the biopsy.The average age in test group and control group was (67.6±8.6) years vs (68.7± 8.8) years,the average PSA level in test group and control group was (105.8±638.1) μg/L vs (174.6±861.4) μg/L,respectively (P>0.05).In test group and control group,the mean duration of present illness was (0.6±2.3) months and (0.4± 1.2) months.The positive rate after the digital rectal examination was 45.3% (68/150) in test group and 51.4% (75/146) in control group.All patients underwent TRUSPB.The infectious complications and the expenditure of medicine in two groups were compared.Results The occurrences of infection complications in test group and control group were 6.0% (9/150) and 6.2% (9/146).Meanwhile,the rate of asymptomatic bacteriuria was 4.7% (7/150) in test group and 3.4% (5/146) in control group.In those groups,the rate of symptomatic urinary tract infection was 0 vs 0.7% (1/146),the rate of fever was 0 vs 0.7% (1/146),the rate of bacteremia was 1.3% (2/150) vs 0 and the rate of urosepsis was 0 vs 1.4% (2/146),respectively (P>0.05).The average costs of medicine in test group and control group were (43.0±3.8) yuan and (403.7±277.6) yuan,respectively (P<0.05).Conclusions Levofloxacin (500 mg,po,qd for 3 days) is an

  15. Ultrasound-guided percutaneous biopsy of digestive tract lesions; Biopsia percutanea de lesiones del tubo digestivo guiada por ecografia

    Energy Technology Data Exchange (ETDEWEB)

    Gil, S.; Martin, I.; Ballesteros, J. M.; Gomez, C. [Hospital General Universitario de Alicante (Spain); Marco, S. F.; Fernandez, P. [Hospital Gneral de Castellon (Spain)

    1999-07-01

    To present our experience in ultrasound-guided percutaneous biopsy of lesions located in the digestive tract. We performed ultrasound-guided percutaneous biopsy in 14 patients (10 men and 4 women) ranging in age from 7 to 71 years (mean; 519 years). The lesions were located throughout the digestive tract, from the pyriform sinus to the sigmoid colon. The biopsy was carried out with a 5 MHz convex probe equipped with a device to direct the needle. An 18G automatic needle or a 20G Chiba needle was used to obtain specimens for histological study in every case, and additional samples were collected with a 22G needle for cytological examination in 13 of the patients. The ultrasound images corresponded to pseudokidney in 9 cases and extrinsic masses in 5. The diagnosis was obtained from the histological examination in every case (100%) and from cytology in 6 (44.4%), the latter results were less specific. The only complication corresponded to a case of bilioperitoneum. Ultrasound-guided percutaneous biopsy is a suitable technique for the histological diagnosis of those lesions of the digestive tract that are visible in ultrasound images, but that for some reason can not be examined by endoscopic biopsy. (Author) 20 refs.

  16. Biopsia y estudio anatomopatológico de una lesión quística de mucosa bucal

    OpenAIRE

    Santángelo, Georgina; Ricciardi, A.; Bogo, P.; Prada, G; Cacciola, S.; Celis, Z.; Di Franco, P.; Teixeira Pocas, M.; Lunaschi, A.

    2015-01-01

    Se presenta a la consulta un paciente de género femenino de 32 años de edad con una lesión única de tipo tumoral ubicada en la cara interna del labio inferior. Clínicamente la lesión se ve elevada, hemiesférica, de base amplia, indolora, de aproximadamente 15 mm de diámetro, cubierta de mucosa sana con características normales. A la palpación se revela blanda y fluctuante. El tiempo de evolución de la lesión es de aproximadamente 3 meses. Diagnóstico presuntivo: Quiste mucoide. Tratamiento: b...

  17. Utilidad de la biopsia de piel en el diagnóstico de enfermedades neurológicas

    OpenAIRE

    de la Sotta F,Pilar; Romero G,William; González B,Sergio

    2008-01-01

    Skin biopsy is a powerful diagnostic tool in Dermatology. Its use has been extended to other medical specialties, aüowing the diagnosis of several diseases that previously required complex and high risk diagnostic procedures. Skin contains numerous cell types, including blood vessels and peripheral nerves and represents a window to the systemic circulation and nervous system. In this review we discuss the use of skin biopsy to diagnose nervous system diseases in which patients do not exhibit ...

  18. Prostate biopsies guided by three-dimensional real-time (4-D) transrectal ultrasonography on a phantom: comparative study versus two-dimensional transrectal ultrasound-guided biopsies

    CERN Document Server

    Long, Jean-Alexandre; Moreau-Gaudry, Alexandre; Troccaz, Jocelyne; Rambeaud, Jean-Jacques; Descotes, Jean-Luc

    2007-01-01

    OBJECTIVE: This study evaluated the accuracy in localisation and distribution of real-time three-dimensional (4-D) ultrasound-guided biopsies on a prostate phantom. METHODS: A prostate phantom was created. A three-dimensional real-time ultrasound system with a 5.9MHz probe was used, making it possible to see several reconstructed orthogonal viewing planes in real time. Fourteen operators performed biopsies first under 2-D then 4-D transurethral ultrasound (TRUS) guidance (336 biopsies). The biopsy path was modelled using segmentation in a 3-D ultrasonographic volume. Special software was used to visualise the biopsy paths in a reference prostate and assess the sampled area. A comparative study was performed to examine the accuracy of the entry points and target of the needle. Distribution was assessed by measuring the volume sampled and a redundancy ratio of the sampled prostate. RESULTS: A significant increase in accuracy in hitting the target zone was identified using 4-D ultrasonography as compared to 2-D....

  19. Evolución clínica en el tratamiento de la entesopatía rotuliana crónica mediante electro-estimulación percutánea ecodirigida: estudio de una serie de casos en población deportiva

    OpenAIRE

    Sánchez Ibáñez, José Manuel

    2013-01-01

    370 p. La tenopatía rotuliana o "rodilla de saltador" se considera más un proceso degenerativo (tendinosis) que inflamatorio (tendinitis). Recientes estudios histopatológicos han demostrado la ausencia de células inflamatorias en este tipo de afección, y han observado la presencia de disrupción de las fibras de colágeno, degeneración mixoide de la sustancia fundamental y signos de hipoxia en los tenocitos y macrófagos residentes. La electrólisis percutánea intratisular (EPI) consiste ...

  20. Is periprostatic nerve block a gold standard in case of transrectal ultrasound-guided prostate biopsy?

    Directory of Open Access Journals (Sweden)

    Ashok Kumar

    2013-01-01

    Conclusions: PNB provides better pain control in TRUS-guided prostate biopsy but still there is need of additional analgesic in the form of tramadol or INB. Tramadol has advantage of oral intake and analgesic effect at time of probe insertion and at nerve block. Both tramadol and INB may be used in combination along with PNB.

  1. Comparison of 3 different methods of anesthesia before transrectal prostate biopsy: a prospective randomized trial

    Energy Technology Data Exchange (ETDEWEB)

    Oebek, C.; Oezkan, B.; Tunc, B.; Can, G.; Yalcin, V.; Solok, V. [University of Istanbul (Turkey). Cerrahpasa School of Medicine. Depts. of Urology and Public Health (GC)

    2004-09-15

    Purpose: Periprostatic nerve block (PNB) is the most common anesthesia technique used before prostate biopsy. However, needle punctures for anesthetic infiltration may be painful and cause higher infectious complications. We assessed whether addition of rectal lidocaine gel would improve its efficacy. We also investigated the efficacy and safety of tramadol, a codeine derivative, as a noninvasive method. Materials and Methods: A total of 300 patients who underwent prostate biopsies were randomized into 4 groups of controls, PNB, perianal/intrarectal lidocaine gel plus PNB and tramadol. Pain was assessed with a numeric analog scale. Results: Each group consisted of 75 patients, and there was a statistically significant difference among pain scores (p = 0.001). Mean pain scores were 4.63 for controls, 2.57 for PNB, 2.03 for infiltration plus gel group and 3.11 for tramadol. Pain and discomfort were least in PNB plus gel arm. The difference of pain score between PNB alone and tramadol group did not reach statistical significance. Infectious complications were higher in the combination group, whereas there were no complications with tramadol. Conclusions: Any form of analgesia/anesthesia was superior to none. The combination of PNB plus gel provided significantly better analgesia compared to PNB alone or tramadol. If this can be duplicated in other trials, the combination may be accepted as the new gold standard of anesthesia for prostate biopsy. The efficacy of tramadol was similar to that of PNB, and was free of complications. Therefore, tramadol may have a role before prostate biopsy, which needs to be explored. (author)

  2. Evaluation of a robotic technique for transrectal MRI-guided prostate biopsies

    Energy Technology Data Exchange (ETDEWEB)

    Schouten, Martijn G. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); University Medical Centre Nijmegen, Department of Radiology, Nijmegen (Netherlands); Bomers, Joyce G.R.; Yakar, Derya; Huisman, Henkjan; Bosboom, Dennis; Scheenen, Tom W.J.; Fuetterer, Jurgen J. [Radboud University Nijmegen Medical Centre, Department of Radiology, Nijmegen (Netherlands); Rothgang, Eva [Pattern Recognition Lab, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen (Germany); Center for Applied Medical Imaging, Siemens Corporate Research (Germany); Center for Applied Medical Imaging, Siemens Corporate Research, Baltimore, MD (United States); Misra, Sarthak [University of Twente, MIRA-Institute of Biomedical Technology and Technical Medicine, Enschede (Netherlands)

    2012-02-15

    To evaluate the accuracy and speed of a novel robotic technique as an aid to perform magnetic resonance image (MRI)-guided prostate biopsies on patients with cancer suspicious regions. A pneumatic controlled MR-compatible manipulator with 5 degrees of freedom was developed in-house to guide biopsies under real-time imaging. From 13 consecutive biopsy procedures, the targeting error, biopsy error and target displacement were calculated to evaluate the accuracy. The time was recorded to evaluate manipulation and procedure time. The robotic and manual techniques demonstrated comparable results regarding mean targeting error (5.7 vs 5.8 mm, respectively) and mean target displacement (6.6 vs 6.0 mm, respectively). The mean biopsy error was larger (6.5 vs 4.4 mm) when using the robotic technique, although not significant. Mean procedure and manipulation time were 76 min and 6 min, respectively using the robotic technique and 61 and 8 min with the manual technique. Although comparable results regarding accuracy and speed were found, the extended technical effort of the robotic technique make the manual technique - currently - more suitable to perform MRI-guided biopsies. Furthermore, this study provided a better insight in displacement of the target during in vivo biopsy procedures. (orig.)

  3. Transrectal combined thickness of the uterus and placenta in normal pregnant Egyptian buffalo-cows.

    Science.gov (United States)

    Zaher, H; Abdalla, H; Labib, F; Eidaroos, A

    2012-04-15

    The combined thickness of the uterus and placenta (CTUP) is one of the characteristics that can be used to assess fetal development and/or placental function in bovine. The current study was designed to establish reference values for the CTUP throughout pregnancy in normal pregnant buffalo-cows. The CTUP at the intracotyledonary space was measured monthly from the second month until full term using electronic calipers of the ultrasound machine. The CTUP increased monthly from 2.5 mm at the second month to 12 mm at the full term. During the last trimester, the monthly increase in the CTUP was higher than that recorded during the first and second trimesters. The result of the current study can be used as normal values for future studies of CTUP in pathologically pregnant buffalo-cows.

  4. Challenges of Zinc-Specific Transrectal Fluorescence Tomography to Detect Prostate Cancer

    Science.gov (United States)

    2013-12-01

    x-ray--guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints," Journal of Biomedical Optics 13(4), 044006-10...2011; accepted December 1, 2011; posted December 1, 2011 (Doc. ID 155485); published March 22, 2012 This is Part III of the work that examines photon...okstate.edu Received March 6, 2012; revised May 11, 2012; accepted May 14, 2012; posted May 16, 2012 (Doc. ID 164299); published June 29, 2012 Part IV examines

  5. Comparison of medical of volume measurement of the prostate by transrectal ultrasound: Experiment with jelly models

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Jeong Yeon; Lee, Hak Jong; Kim, Sung Hyun [Samsung Seoul Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Kim, Seung Hyup [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2002-03-15

    To evaluate the accuracy of measuring the volume of the prostate using the prolate ellipsoid volume calculation method (antero-posterior (AP) diameter X length X width X {pi}6) when the antero-posterior diameter of the prostate was measured on midsagittal (sagittal volume) and axial plane (axial volume).The devil's tongue jelly was used for the creation of ultrasound model of the prostate (volume: 15-40 cc) by cutting and shaping the surface. The volume in 10 prostatic models and 30 patients was measured and calculated. First, the AP diameter and length of the prostate models in midsagittal plane, and the height and width of the models in axial plane were measured for 3 times. The volume was calculated in two ways, one using the AP diameter an midsagittal plane and the other using the AP diameter in axial plane. The true volume of the model was measured using mess cylinder. The calculated volume and true volume were compared, and the accuracy of two method of measuring the prostatic volume was evaluated by Friedman test. The intraobserver variation was evaluated by General Linear Model, Repeated Measure. The reproducibility was evaluated by Cronbach's {alpha}. In vivo study was also performed in 30 patients. The prostate volume was calculated in the same manner. These volume data were analyzed by statistical method, and the intraobeserver variation was evaluated. While there was a statistically significant difference between the sagittal and true volume of the models, there was no statistical significant difference between the axial and true volumes. There was no significant intraobserver variation between both methods. The reproducibility was high in both methods with Cronbach's {alpha} of 0.977 and 0.942. The sagittal volume was larger than the axial volume in 30 patients with a statistically significant difference. There was no significant intraobserver variation in both methods. The reproducibility was high in both methods Cronbach's {alpha} of 0.991 and 0994. The volumetric methods for the prostate using the antero-posterior diameter measured in axial plane was more accurate than on midsagittal plane.

  6. Safety of ultrasound-guided transrectal extended prostate biopsy in patients receiving low-dose aspirin

    Directory of Open Access Journals (Sweden)

    Ioannis Kariotis

    2010-06-01

    Full Text Available PURPOSE: To determine whether the peri-procedural administration of low-dose aspirin increases the risk of bleeding complications for patients undergoing extended prostate biopsies. MATERIALS AND METHODS: From February 2007 to September 2008, 530 men undergoing extended needle biopsies were divided in two groups; those receiving aspirin and those not receiving aspirin. The morbidity of the procedure, with emphasis on hemorrhagic complications, was assessed prospectively using two standardized questionnaires. RESULTS: There were no significant differences between the two groups regarding the mean number of biopsy cores (12.9 ± 1.6 vs. 13.1 ± 1.2 cores, p = 0.09. No major biopsy-related complications were noted. Statistical analysis did not demonstrate significant differences in the rate of hematuria (64.5% vs. 60.6%, p = 0.46, rectal bleeding (33.6% vs. 25.9%, p = 0.09 or hemospermia (90.1% vs. 86.9%, p = 0.45. The mean duration of hematuria and rectal bleeding was significantly greater in the aspirin group compared to the control group (4.45 ± 2.7 vs. 2.4 ± 2.6, p = < 0.001 and 3.3 ± 1.3 vs. 1.9 ± 0.7, p < 0.001. Multivariate logistic regression analysis revealed that only younger patients (mean age 60.1 ± 5.8 years with a lower body mass index (< 25 kg/m2 receiving aspirin were at a higher risk (odds ratio = 3.46, p = 0.047 for developing hematuria and rectal bleeding after the procedure. CONCLUSIONS: The continuing use of low-dose aspirin in patients undergoing extended prostatic biopsy is a relatively safe option since it does not increase the morbidity of the procedure.

  7. Current status of transrectal ultrasound-guided prostate biopsy in the diagnosis of prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Raja, J. [Department of Radiology, St George' s Hospital, Tooting, London (United Kingdom)]. E-mail: jowadraja@gmail.com; Ramachandran, N. [Department of Radiology, St George' s Hospital, Tooting, London (United Kingdom); Munneke, G. [Department of Radiology, St George' s Hospital, Tooting, London (United Kingdom); Patel, U. [Department of Radiology, St George' s Hospital, Tooting, London (United Kingdom)

    2006-02-15

    In contemporary practice, most prostate cancers are either invisible on ultrasound or indistinguishable from concurrent benign prostatic hyperplasia. Diagnosis therefore rests on prostate biopsy. Biopsies are not simply directed at ultrasonically visible lesions, as these would miss many cancers; rather the whole gland is sampled. The sampling itself is systematic, using patterns based on prostate zonal anatomy and the geographical distribution and frequency of cancer. This review explains the evolution of the prostate biopsy technique, from the classical sextant biopsy method to the more recent extended biopsy protocols (8, 10, 12, >12 and saturation biopsy protocols). Extended protocols are increasingly being used to improve diagnostic accuracy, especially in those patients who require repeat biopsy. This trend has been facilitated by the ongoing improvement in safety and acceptability of the procedure, particularly with the use of antibiotic prophylaxis and local anaesthesia. The technical details of these extended protocols are discussed, as are the current data regarding procedure-related morbidity and how this may be minimized.

  8. Bacteriology profile of febrile infectious complications after transrectal ultrasound-guided prostate biopsy

    Directory of Open Access Journals (Sweden)

    Tzu-Hao Huang

    2014-09-01

    Conclusion: Our study demonstrated an overall postbiopsy febrile complicating infection rate of 1.39%. E. coli was the most common pathogen. Fluoroquinolones or second generation cephalosporins are suggested as the initial choice in patients with postbiopsy fever.

  9. [Transrectal echography in the assessment of anastomosis and local recurrence after prior resection].

    Science.gov (United States)

    Iannicelli, E; Fusaro, P L; Manganaro, L; Conforti, G; Di Nardo, R; Drudi, F M; Passariello, R

    1993-05-01

    The value of rectal endosonography was investigated in the follow-up of the patients submitted to anterior resection for rectal cancer. Rectal endosonography was performed on 42 patients who had been operated on two months to five years before; all patients were monitored according to a carefully planned follow-up schedule including clinical and instrumental examinations and laboratory tests. Sixteen patients had altered clinical and laboratory data; 26 were completely asymptomatic. In the latter group, no signs of local recurrences were found, while in 4 cases the rectal wall appeared homogeneously thickened and hypoechoic: this pattern was due to postoperative or post-irradiation hyperemic-edematous phenomena. In 14 of 16 symptomatic patients, a mass was detected--in 9 of them inhomogeneous and hypoechoic and developing mainly in the perirectal perianastomotic tissue and in 5 limited to the rectal wall, in the anastomotic area. In the last 2 cases, no lesions were found. Both the manual and the stapler anastomoses were always demonstrated, which exhibited different US patterns. US findings were compared with histologic results or were clinically checked in the subsequent follow-up. To conclude, rectal endosonography proved to be useful in the postoperative follow-up of this kind of patients even though it did not allow the differential diagnosis between fibrosis and local recurrence.

  10. Percutaneous computed tomography-guided biopsy of the lung: data from a hospital; Biopsia pulmonar percutanea guiada por tomografia computadorizada: dados de um hospital

    Energy Technology Data Exchange (ETDEWEB)

    Carazzai, Emilio Humberto; Rossi, Marcelo D' Andrea [Maximagem Diagnosticos por Imagem, Sao Paulo, SP (Brazil); Andreosi, Maristela [Hospital Beneficencia Portuguesa, Sao Paulo, SP (Brazil); Gonzalez, Fabio Mota; Tornin, Olger de Souza [Hospital Heliopolis, Sao Paulo, SP (Brazil)]. E-mail: olger1@uol.com.br; Gonzalez, Sandra de Quadros Uzeda [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil)

    2006-07-15

    Objective: to present the experience of Santa Cecilia Hospital (Sao Paulo, SP, Brazil) radiology service in the handling of computed tomography-guided fine-needle aspiration biopsy and percutaneous core biopsy of pulmonary lesions, analyzing their importance and associated complications. Materials and methods: one hundred and sixty-eight computed tomography-guided biopsies were performed in 84 men and 84 women. Sixty-four patients underwent fine-needle aspiration biopsy, 68 underwent percutaneous core biopsy and 36 patients underwent both techniques. Results: pneumothorax occurred in 38 patients, and pulmonary hemorrhage in then cases. The biopsied lesions ranged in size from 0.5 to 15 cm. The diagnosis was achieved at the first attempt in 132 cases and at the second attempt, in ten cases. Conclusion: the accuracy of fine-needle aspiration and percutaneous core biopsies depends both on the size of the lesion and the patient's cooperation. These techniques are relatively safe and present a high diagnostic accuracy when performed by an experienced professional. (author)

  11. Computed tomography-guided percutaneous biopsy of pancreatic masses using pneumodissection; Biopsia percutanea de massas pancreaticas guiada por tomografia computadorizada com pneumodisseccao

    Energy Technology Data Exchange (ETDEWEB)

    Tyng, Chiang Jeng; Bitencourt, Almir Galvao Vieira; Almeida, Maria Fernanda Arruda; Barbosa, Paula Nicole Vieira; Martins, Eduardo Bruno Lobato; Junior, Joao Paulo Kawaoka Matushita; Chojniak, Rubens, E-mail: chiangjengtyng@gmail.com [Hospital A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Imagem; Coimbra, Felipe Jose Fernandez [Hospital A.C. Camargo, Sao Paulo, SP (Brazil). Dept. de Cirurgia Abdominal

    2013-05-15

    Objective: to describe the technique of computed tomography-guided percutaneous biopsy of pancreatic tumors with pneumodissection. Materials and methods: in the period from June 2011 to May 2012, seven computed tomography guided percutaneous biopsies of pancreatic tumors utilizing pneumodissection were performed in the authors' institution. All the procedures were performed with an automatic biopsy gun and coaxial system with Tru-core needles. The biopsy specimens were histologically assessed. Results: in all the cases the pancreatic mass could not be directly approached by computed tomography without passing through major organs and structures. The injection of air allowed the displacement of adjacent structures and creation of a safe coaxial needle pathway toward the lesion. Biopsy was successfully performed in all the cases, yielding appropriate specimens for pathological analysis. Conclusion: Pneumodissection is a safe, inexpensive and technically easy approach to perform percutaneous biopsy in selected cases where direct access to the pancreatic tumor is not feasible. (author)

  12. La biopsia con aguja gruesa guiada mediante estereotaxia en el diagnóstico de las lesiones mamarias sospechosas de malignidad

    OpenAIRE

    Hidalgo Pérez, José Alberto

    2000-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada El cáncer de mama es una enfermedad en la que no es posible la prevención primaria por lo que para disminuir la morbimortalidad es imprescindible un diagnóstico precoz que permita un tratamiento efectivo. Dado que en las campañas de cribado y en las mamografías de control se diagnostican muchas lesiones de las que no es posible saber si se trata o no de lesiones malignas hasta que no se biopsian, son necesarias técnicas ...

  13. Utility of color Doppler transrectal ultrasound in the diagnosis of prostate cancer: a study of 101 cases; Utilidad de la ecografia transrectal con Doppler color en el diagnostico del cancer de prostata. Estudio de 101 casos

    Energy Technology Data Exchange (ETDEWEB)

    Morales, F. J.; Jornet, J.; Cervera, J.; Labrador, T. [Instituto Valenciano de Oncologia. Valencia (Spain)

    2001-07-01

    To determine the value of color Doppler ultrasound in the detection of prostate cancer. To relate asymmetries in vascularisation with the results of directed biopsy. Between May and November 2000, we studied 101 patients suspected of having prostate cancer. The selection criteria were a prostate-specific antigen level of over 3 ng/ml, suspicious digital rectal examination or both. The volume, capsule and internal architecture were assessed, focusing on nodules, suspicious hypoechoic areas and asymmetric color intensity. Sextant biopsies were carried out with an 18-gauge needle and samples were also taken of the areas of increased color intensity. (Author) 16 refs.

  14. Comparison of two techniques of transrectal ultrasonography for the assessment of local extent of polypoid tumours of the rectum

    DEFF Research Database (Denmark)

    Rafaelsen, Søren Rafael; Kronborg, Ole; Fenger, Claus;

    1996-01-01

    was extended with an acoustic window system (AWS), preventing compression of the polyp. Pathological examination after surgical resection was used for definitive diagnosis in 110 polyps. Digital examination detected 10 of 22 carcinomas with adenomas, compared with 19 by TRUS (P

  15. The accuracy and safety aspects of a novel robotic needle guide manipulator to perform transrectal prostate biopsies.

    NARCIS (Netherlands)

    Schouten, M.G.; Ansems, J.; Renema, W.K.J.; Bosboom, D.G.H.; Scheenen, T.W.J.; Futterer, J.J.

    2010-01-01

    PURPOSE: To introduce a new in-house developed pneumatically controlled magnetic field compatible manipulator as an aid to perform magnetic resonance (MR)-guided biopsies of the prostate. METHODS: A pneumatic controlled manipulator with five degrees of freedom constructed of plastic to achieve magne

  16. Intra-operative dosimetry of trans-rectal ultrasound guided 125I prostate implants using C-arm fluoroscopic images

    Directory of Open Access Journals (Sweden)

    Ravindran Paul

    2006-01-01

    Full Text Available Permanent implantation of radioactive seeds is a viable and effective therapeutic option widely used today for early-stage prostate cancer. The implant technique has improved considerably during the recent years due to the use of image guidance; however, real-time dose distributions would allow potential cold spots to be assessed and additional seeds added. In this study, we investigate the use of a conventional C-arm fluoroscopy unit for image acquisition and evaluation of dose distribution immediately after the implant. The phantom study indicates that it is possible to obtain seed positions within ±2 mm. A pilot study carried out with three patients indicated that it is possible to obtain seed positions and calculate the dose distribution with C-arm fluoroscopy and about 95% of the seeds were reconstructed within ±2 mm. The results could be further improved with better digital imaging.

  17. The usefulness of transrectal endosonography in differentiating an anal abscess from a rectal carcinoma: a case report:

    OpenAIRE

    Kolodziejczak, Malgorzata; Sudoł-Szopińska, Iwona

    2005-01-01

    Background. The high anal abscess might have not a typical, chronic clinical course, and its diagnosis may be difficult. Case report. The authors describe a case of a patient with the initial diagnosis of rectal cancer. Because of non-specific clinical symptoms suggesting a high anal abscess with atypical , chronic course of the disease, additional investigations were suggested. The final diagnosis was high, submucous-intersphincetric abscess. Conclusions. In the described case the most impor...

  18. 3D versus 2D Systematic Transrectal Ultrasound-Guided Prostate Biopsy: Higher Cancer Detection Rate in Clinical Practice

    Directory of Open Access Journals (Sweden)

    Alexandre Peltier

    2013-01-01

    Full Text Available Objectives. To compare prostate cancer detection rates of extended 2D versus 3D biopsies and to further assess the clinical impact of this method in day-to-day practice. Methods. We analyzed the data of a cohort of 220 consecutive patients with no prior history of prostate cancer who underwent an initial prostate biopsy in daily practice due to an abnormal PSA and/or DRE using, respectively, the classical 2D and the new 3D systems. All the biopsies were done by a single experienced operator using the same standardized protocol. Results. There was no significant difference in terms of age, total PSA, or prostate volume between the two groups. However, cancer detection rate was significantly higher using the 3D versus the 2D system, 50% versus 34% (P<0.05. There was no statistically significant difference while comparing the 2 groups in term of nonsignificant cancer detection. Conclusion. There is reasonable evidence demonstrating the superiority of the 3D-guided biopsies in detecting prostate cancers that would have been missed using the 2D extended protocol.

  19. Transrectal endoscopy with three different techniques of rectal suture associate: NOTES survival study with liver biopsy in a swine model

    Directory of Open Access Journals (Sweden)

    A.B. Trindade

    2015-08-01

    Full Text Available A cirurgia endoscópica por orifícios naturais (NOTES representa um novo conceito de cirurgia, caracterizada por ausência de incisões abdominais. Os acessos mais comumente usados são o transvaginal e o transgástrico. Entretanto, as rotas transcolônica e transretal representam alternativas promissoras. O presente estudo objetiva avaliar três diferentes técnicas de sutura retal em três suínos submetidos a NOTES transretal para biópsia hepática, avaliando-se concomitantemente as repercussões clínicas e hematológicas. Sob anestesia geral, foi realizada uma incisão transversal no reto para a passagem do endoscópio até a cavidade abdominal em todos os animais para a realização da biópsia hepática. Cada animal recebeu um tipo de sutura retal: sutura em dois planos; reforço com tela de polipropileno ou reforço com membrana de pericárdio bovino. A NOTES transretal em modelo experimental suíno não apresentou implicações clínicas e hematológicas importantes, o que demonstra um acesso alternativo para biópsia hepática. Nenhum animal apresentou sinais de peritonite, aderências ou deiscência de pontos. O uso de reforço com pericárdio bovino para a sutura retal apresenta um atraso na cicatrização quando comparado com a sutura convencional ou com o uso de tela de polipropileno.

  20. Transrectal impalement of an incense stick in a child presenting as foreign body in the urinary bladder.

    Science.gov (United States)

    Mahapatra, Rajkumar Singha; Priyadarshi, Vinod; Madduri, Vijay Kumar Sarma; Pal, Dilip Kumar

    2014-06-12

    The diversity of objects that can be found in the urinary bladder often surpasses the urologist's imagination and mostly they are introduced per urethrally. Impalement injuries of the rectum with bladder perforation have been rarely reported. A high index of clinical suspicion is required to make the diagnosis of bladder perforation while assessing patients presenting with rectal impalement. In this interesting case, a young male child presented with haematuria and dysuria. He had a history of accidentally sitting on an agarbatti (Indian incense stick) stand while playing, followed by perianal pain which subsided spontaneously. Next day he presented with haematuria and dysuria. Clinical examination was inconclusive. On thorough investigation, a linear echogenic foreign body was found in the urinary bladder. The child was operated and the foreign body (incense stick) was removed. This is the first reported case of rectal impalement injury with incense stick, migrated to the urinary bladder in a 2-year-old child.

  1. Magnetic resonance (MR) imaging of prostatic tumours, a comparison with X-ray CT and transrectal sonography (TRS)

    Energy Technology Data Exchange (ETDEWEB)

    Bockisch, A.; Biersack, H.J.; Huenermann, B.; Schmitz, H.G.; Knopp, R.; Winkler, C.; Jaeger, N.; Vahlensieck, W.; Christ, F.

    1988-02-01

    A total of 7 healthy volunteers and 31 patients have been examined clinically, by MRI, TRS, and biopsy. In those patients with established carcinoma, a CT examination was also performed. For the MRI study, a superconducting MR 2000 imager (Picker International) operated at 0.15 T was used with multiplanar SE and IR sequnces. SE sequences with long echo times detected prostatitis, adenoma and carcinoma of the prostate with a high degree of sensitivity. However, at present, differentiation between adenoma, prostatis and carcinoma is not possible with sufficient accuracy. In these studies we were unable to establish a correlation between the signal pattern and staging and/or grading of the carcinoma. Reliable diagnosis of a prostate carcinoma still requires a biopsy. Because of the high soft tissue contrast and the possibility of selecting any orientation for the plane under investigation, however, MRI represents an improvement in the preoperative diagnosis of local spread.

  2. Location studies of prostate volume measurement by using transrectal ultrasonography: Experimental study by self-produced prostate phantom

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Joon; Byeon, Il Kyun; Lee, Hoo Min [Dept. of Radiological Science, (Korea, Republic of); Kim, Yun Min; Kim, Hyeong Gyun [Dept. of Radiological Technology, Dongnam Health University, Suwon (Korea, Republic of)

    2015-12-15

    Accurate volume measurement of the prostate is a significant role in determining the result of diagnosis and treatment of benign prostate hyperplasia. The purpose of this study was to determine, when measuring prostate volume by TRUS, whether location is more accurately determined by transaxial or longitudinal scanning. With reference to the patient’s image, it was produced six prostate model. It compares the actual volume and the measurement volume, and find the optimal measurement position of each specific model. Prostate volume measured by TRUS closely correlates with prostate phantom volume. There was no significant difference(p = .156). To measure the accurate volume of prostate with focal protrusion, its length should be measured exclude the protrusions.

  3. Prostatic fiducial markers implantation by transrectal ultrasound for adaptive image guided radiotherapy in localized cancer: 7-years experience

    Directory of Open Access Journals (Sweden)

    Vito Lacetera

    2014-12-01

    Full Text Available Objective: we present our 7-years’ experience with fiducial gold markers inserted before Image-Guided Radiotherapy (IGRT focusing on our echo-guided technique reporting early and late complications. Material and methods: 78 prostate cancer (PCA patients who underwent fiducial markers placement for adaptive IGRT (period 2007-2014 were selected. Mean patient age was 75 years (range 60-81, mean PSA 7.8 ng/ml (range 3.1-10, clinical stage < T3, mean Gleason Score 6.4 (range 6-7. We recorded early and late complications. Maximum distance between the Clinical Target Volume (CTV and Planning Target Volume (PTV was assessed for each direction and the mean PTV reduction was estimated. Results: we describe in details our echo-guided technique of intraprostatic gold fiducial markers insertion prior to adaptative IGRT. We report rare early toxicity (5-7% grade 1-2, a mean PTV reduction of 37% and a very low late toxicity (only 3.4% bladder G3 and 8% rectal G2 side effects. Conclusion: Our technique of fiducial gold markers implantation for adaptative IGRT is safe and well-tolerated and it resulted helpful to reduce CTV-PTV margin in all cases; the effects on clinical practice seem significant in terms of late toxicity but further investigations are needed with longer follow-up.

  4. Inflamación granulomatosa crónica: métodos de detección de bacilos ácido alcohol resistentes en biopsias embebidas en parafina

    OpenAIRE

    Bustamante Rengifo Javier Andres; Bravo Ocaña Luis Eduardo; Pazos Mocayo Alvaro Jairo; Astudillo Hernadez Miryam

    2010-01-01

    La detección de bacilos ácido alcohol resistentes (BAAR) en frotis resulta un aporte significativo al diagnóstico y tratamiento de individuos con inflamación granulomatosa crónica (IGC). Con el objetivo de evaluar la presencia de BAAR en diferentes tejidos de pacientes con I...

  5. Valoracion de la calidad del injerto hepático mediante la determinación de los patrones metabonómicos en biopsia del hígado donante

    OpenAIRE

    Cortes Cerisuelo, Miriam

    2015-01-01

    El trasplante de hígado (TH) constituye en el tratamiento de elección para las enfermedades hepáticas en estadio terminal, sin embargo, el desequilibrio entre el número de donantes y pacientes en lista de espera ha conducido a la utilización de injertos procedentes de donantes con criterios extendidos. Esta práctica, se ha traducido en una reducción de la tasa de mortalidad entre los pacientes en lista de espera, a expensas de un aumento de las complicaciones post-trasplante, como la disfunci...

  6. Biopsia por aspiración con aguja fina (BAAF) para el diagnóstico de linfoma no hodking cutáneo asociado a HTLV I-II. Presentación de caso.

    OpenAIRE

    Núñez Carrión., Ericka Cecilia

    2010-01-01

    INTRODUCCIÓN: El HTLV-1 es el primer retrovirus oncógeno humano que fue aislado por vez primera. Más tarde se demostró que el virus del linfoma leucemia de células T humanas (HTLV-1) era el agente causal de la Leucemia/linfoma de células T del adulto (ATL). EL HTLV-1 es más común en Japón y en el Caribe que en los Estados Unidos. También se ha descrito posteriormente en varios países latinoamericanos incluyendo Perú. El HTLV-1 pertenece a la familia de los retrovirus humanos, con tropismo pos...

  7. Development of a software of quantification of tumour density from images of biopsies from caner of head and neck; Desarrollo de un software de cuantificacion de densidad tumoral a partir de imagenes de biopsias de cancer de cabeza y cuello

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, J. M.; Alba, J. L.; Mera, M.; Lorenzo, Y.; Iglesias, M. B.; Lopez Medina, A.; Munoz, A.

    2013-07-01

    It has developed a software for automatic quantification of tumoral tissues biopsied density and tinted with Cytokeratin, using information colorimetric and morphologic, that also allows to distinguish between malignant cells and healthy cells. The software allows you to find, within the area biopsied, the area 1 mm{sub 2} with higher tumor density, which in the future may be associated with ADC minimum of the number of patients included in the ARTFIBio project and be able to check the inverse correlation between the two measures. (Author)

  8. Leishmania spp. parasite isolation through inoculation of patient biopsy macerates in interferon gamma knockout mice Leishmania spp.: isolamento de parasitos pela inoculação de macerados de biopsias de pacientes em camundongos deficientes em interferon gama

    Directory of Open Access Journals (Sweden)

    Milton Adriano Pelli de Oliveira

    2010-04-01

    Full Text Available Isolation of Leishmania parasite and species identification are important for confirmation and to help define the epidemiology of the leishmaniasis. Mice are often used to isolate pathogens, but the most common mouse strains are resistant to infection with parasites from the Leishmania (Viannia subgenus. In this study we tested the inoculation of interferon gamma knockout (IFNγ KO mice with biopsy macerates from Leishmania-infected patients to increase the possibility of isolating parasites. Biopsies from twenty five patients with clinical signs of leishmaniasis were taken and tested for the presence of parasites. Immunohistochemical assay (IHC and conventional histopathology detected the parasite in 88% and 83% of the patients, respectively. Leishmania sp. were isolated in biopsy macerates from 52% of the patients by culture in Grace's insect medium, but 13% of isolates were lost due to contamination. Inoculation of macerates in IFNγ KO mice provides isolation of parasites in 31.8% of the biopsies. Most isolates belong to L. (Viannia subgenus, as confirmed by PCR, except one that belongs to L. (Leishmania subgenus. Our preliminary results support the use of IFNγ KO mice to improve the possibility to isolate New World Leishmania species.O isolamento e a identificação da espécie de parasito do gênero Leishmania são importantes para a confirmação e auxiliam na epidemiologia da leishmaniose. Os camundongos são freqüentemente utilizados para isolar patógenos, porém, as linhagens mais comuns de camundongos são resistentes à infecção por parasitos do subgênero Leishmania (Viannia. Neste estudo, avaliamos a inoculação de macerados de biópsias de pacientes infectados em camundongos deficientes do gene do interferon gama (IFNγ KO como um método para aumentar a possibilidade de isolar Leishmania spp. Biópsias de 25 pacientes infectados com Leishmania sp. foram avaliadas para a presença de parasitos pelos métodos de imunohistoquímica (IHC e histopatologia convencional. Os parasitos foram observados, respectivamente, em 88% e 83% das biópsias. Leishmania sp. foi isolada de macerados de biópsia de 52% dos pacientes infectados, quando cultivados em meio Grace, porém, 13% destes isolados foram perdidos devido a contaminações. Inoculação dos macerados em camundongos IFNγ KO proporcionou o isolamento de parasitos oriundos de 31,8% dos pacientes. A maioria dos isolados pertence ao subgênero L. (Viannia, exceto um que pertence ao subgênero L. (Leishmania, como confirmado pela reação da polimerase em cadeia. Nossos resultados preliminares sugerem que o uso de camundongos IFNγ KO pode ser útil para aumentar a possibilidade de isolamento de leishmânias encontradas nas Américas.

  9. Epidemiología retrospectiva y análisis de las características múltiples del carcinoma espinocelular de la mucosa bucal con estudio histopatológico de biopsias

    OpenAIRE

    Baudo, Judith Ethel

    2000-01-01

    La Organización Mundial de la Salud ha venido estableciendo parámetros de estudio histológico y clasificaciones de las enfermedades precancerosas y carcinoma oral. Ha efectuado distintas revisiones con el fin de implicar los conceptos para los patólogos de todas las naciones. El objetivo general de este trabajo fue actualizar los aspectos epidemiológicos, clínicos, condicionantes, etiológicos, y de diagnóstico, pronóstico y tratamiento del carcinoma a células escamosas de la mucosa bucal. ...

  10. Comparação entre a citopatologia por biopsia com agulha fina e a histopatologia no diagnóstico das neoplasias cutâneas e subcutâneas de cães

    Directory of Open Access Journals (Sweden)

    Paulo H. Braz

    2016-03-01

    Full Text Available Resumo: Os neoplasmas cutâneos estão entre os mais diagnosticados em medicina veterinária, diante disso busca-se que o diagnóstico desses tumores seja rápido e eficaz. Em medicina veterinária o uso da citopatologia como método para diagnóstico tornou-se crescente. Diante disso, é necessário que estudos comprovem a eficiência da técnica para que a mesma possa ser usada de maneira isolada. Este trabalho teve como objetivo comparar o diagnóstico obtido pelas técnicas citopatológica e histopatológica de tumores cutâneos e subcutâneos de cães, determinar qual o tipo neoplásico mais facilmente diagnosticado pela citopatologia e a neoplasia mais prevalente nesses animais, atendidos em dois hospitais veterinários de Campo Grande/MS, no período de março de 2012 a dezembro de 2013. Foram coletadas amostras celulares de tumores de 91 cães, através de punção aspirativa por agulha fina e punch cirúrgico Os resultados citopatológicos demonstraram uma eficácia de 69,69%, em relação à histopatologia. Para a diferenciação entre tumores neoplásicos e não neoplásicos, a eficiência aumenta, com resultados iguais em 91,91%. Para diferenciar tumores benignos de malignos, foi possível chegar a uma concordância na ordem de 68,13%. Os tumores mais prevalentes foram o mastocitoma, seguido do lipoma, fibrossarcoma e tumor de célula basal.

  11. Early experience with multiparametric magnetic resonance imaging-targeted biopsies under visual transrectal ultrasound guidance in patients suspicious for prostate cancer undergoing repeated biopsy

    DEFF Research Database (Denmark)

    Boesen, Lars; Noergaard, Nis; Chabanova, Elizaveta;

    2015-01-01

    in all 39 patients. Both PI-RADS and Likert scoring showed a high correlation between suspicion of malignancy and biopsy results (p Gleason score....... MATERIAL AND METHODS: Eighty-three patients with prior negative TRUS-bx scheduled for repeated biopsies due to persistent suspicion of PCa were prospectively enrolled. mp-MRI was performed before biopsy and all lesions were scored according to the Prostate Imaging Reporting and Data System (PI...... upgrade of at least one grade based on the mp-MRI-bx. Secondary PCa lesions not visible on mp-MRI were detected by TRUS-bx in six out of 39 PCa patients. The secondary foci were all Gleason 6 (3 + 3) in 5-10% of the biopsy core. According to the Epstein criteria, 37 out of 39 cancer patients were...

  12. 经直肠超声在前列腺囊肿诊断中的价值%Value of transrectal ultrasonography in the diagnosis of prostatic cyst

    Institute of Scientific and Technical Information of China (English)

    李巍; 胡峻岭; 张桂萍; 潘秀梅; 田然; 黄谨谦

    2005-01-01

    目的探讨经直肠超声前列腺检查对前列腺囊肿的早期诊断价值.方法全部病例均行经腹超声(TAS)及经直肠超声(TRUS)对比检查.结果 110例前列腺疾患者,TAS检出7例(6%)前列腺囊肿,TRUS检出24例(22%)前列腺囊肿,两种方法的检出率及不同年龄组的患病率有明显差异.结论 TRUS对前列腺囊肿的探测敏感性高于TAS,而且可进一步帮助定性诊断,是诊断前列腺囊肿的理想方法.

  13. Utilidad de la videonasofibroscopía en el diagnóstico histológico del cáncer de laringe

    OpenAIRE

    Herrera J,María José; Urbano M,Hernán; Rahal E,Maritza

    2014-01-01

    Introducción: La laringoscopía directa (LD) se considera indispensable en el estudio del cáncer de laringe, tanto para precisar la extensión como para tomar biopsia. Objetivo: Demostrar que el resultado de biopsias tomadas por videonasofibroscopía (VFC) en cáncer de laringe es equivalente al de la biopsia definitiva. Material y método: Revisión de fichas de 53 pacientes del Servicio de Otorrinolaringología HBLT con sospecha de cáncer de laringe con biopsia realizada por VFC y definitiva, dura...

  14. 经直肠超声定位下前列腺穿刺活检术的探讨%Transrectal Ultrasounography Guided Prostate Biopsy and its Influencing Factors

    Institute of Scientific and Technical Information of China (English)

    杜科霖; 欧阳骏; 丁翔; 温端改

    2011-01-01

    目的 探讨理想的前列腺穿刺活检方案.方法 回顾性分析127例疑诊为前列腺癌患者的年龄、直肠指检(DRE)或经直肠超声(TRUS)情况、血清前列腺特异性抗原(PSA)水平、前列腺体积大小、穿刺针数等,与穿刺活检阳性率的关系.结果 127例穿刺活检结果显示:前列腺增生症(BPH)80例,前列腺癌(Pca)47例,Pca活检阳性率为37.9%;随着患者年龄的增长及PSA水平的增高,Pca检出率明显增高,差异有统计学意义(P<0.05),对前列腺体积不同患者,采用不同穿刺活检方案,其Pca活检阳性率不等,小体积前列腺患者,系统6针、10针、12针穿刺活检三组阳性率比较差异无统计学意义(P>0.05),大体积前列腺患者,12针穿刺活检阳性率明显高于系统6针的.直肠指检阳性组穿刺活检阳性率与阴性组比较有统计学意义(P<0.05).结论 对不同的初次前列腺活检患者,应当根据患者的个体情况选择不同的穿刺活检方案.%Objective To investigate the impaction of different prostate biopsy strategies on the prostate cancer detection. Methods 127 men who were highly suspected as prostate cancer were included in this study. Retrospective analysis the relationship hetween the patient ' s age , DRE or TRUS conditions . PSA levels , prostate volume size , the numher of needle and the biopsy positive rate. Results Of the 127 patients, prostate cancers were detected in 47 ( 37.9% ). The positive rate of prostate cancer was positively correlated with the age of the patients and the PSA levels ( P < 0. 05 ). In the patients with small prostate volume, there was no significant difference in the dete.ction rate of prostate cancer between 6-, 10-, and 12-core protocols ( P >0. 05 ). But In the patients with large prostate volume, the detection rate by 12-core protocol was significantly higher than that hy 6-core protocol ( 36. 9% vs. 12. 8% , P > 0. 05 ). The detection rate of the prostate canc:er was significantly higher in the patients with positive DRE compared with those with negative DRE ( P < 0. 05 ). Conclusion Different biopsy strategies should he used in patients with different age,DRE or TRUS status.PSA levels.

  15. 经直肠前列腺活检的单中心16年回顾%Transrectal prostate biopsy:a review of 16 years experience in single center

    Institute of Scientific and Technical Information of China (English)

    潘永昇; 王增军; 华立新; 成功; 汪骏; 李潇; 张成; 吴杰; 郑雨潇; 黄源; 秦超

    2016-01-01

    目的:分析前列腺活检技术变化对阳性率的影响,探讨活检阳性患者的流行病学变化,尤其PSA应用后对前列腺癌诊断及危险度分级的影响。方法回顾性分析本中心1999年3月至2015年3月3762例前列腺活检患者的临床资料。年龄22~93岁,平均69岁。所有患者均接受经直肠前列腺活检。分析PSA各区间的活检阳性率和并发症,比较手指引导下6针、8针活检法与经直肠超声( TRUS)引导下12+1针活检法的阳性率,总结历年活检阳性患者的PSA、年龄及Gleason评分变化趋势。结果本中心共行前列腺活检3762例,总体阳性率为39.3%。手指引导下6针活检1006例,阳性率为31.0%;8针活检398例,阳性率为36.2%;TRUS引导下12+1针活检2258例,阳性率43.9%,高于手指引导(43.9% vs.32.4%,P<0.001)。总前列腺特异抗原(tPSA)异常组(PSA>4 ng/ml)的阳性率低于直肠指检(DRE)异常组(37.8% vs.57.6%,P<0.001),tPSA异常组的Gleason评分均值也低于DRE异常组(6.88 vs.7.14,P<0.001)。前列腺外周6针的阳性率高于内侧6针(37.5%vs.31.4%,P<0.001),第13针的阳性率高于前12针平均阳性率(70.7% vs.56.6%,P<0.001)。术后发生轻微肉眼血尿或镜下血尿1312例(34.9%),肉眼血尿56例(1.5%),直肠出血72例(1.9%),发热63例(1.7%),肝肾功能衰竭及死亡各1例(0.03%,0.03%)。自1999年始,前列腺活检的阳性率逐渐上升。随着tPSA的升高,阳性患者的Gleason评分逐渐升高。近10年低危患者比例从6.5%逐渐上升到15.7%。2009年后因tPSA升高就诊行前列腺活检的患者较2009年以前显著增加(46.7%vs.34.1%, P<0.001)。因tPSA升高就诊行前列腺活检患者的阳性率较以下尿路症状(LUTS)为主诉的患者无明显差异(45.2% vs.43.2%,P=0.362),但其阳性患者的Gleason评分均值低于LUTS组(6.76 vs.7.25,P<0.001)。结论 TRUS引导下经直肠12+1针活检方案阳性率显著高于手指引导下6针及8针活检。随着PSA的应用,前列腺活检的阳性率逐渐增高,阳性者的年龄呈下降趋势;年龄越大,前列腺活检的阳性率越高;直肠指检阳性患者,活检的Gleason评分偏高;外周区的活检有利于前列腺癌的检出;tPSA水平越高,前列腺活检的Gleason评分越高。 TRUS引导的前列腺12+1针活检检出的低危患者有增加趋势,但多数仍为有临床意义的前列腺癌。%Objective To assess the improvement of prostate cancer detection rate ( PCDR) with the advance of prostate biopsy technologies and analyse the changing epidemiology of patients with positive prostate biopsy, especially the PCDR and classficaton of risk.Methods From March 1999 to March 2015, a total of 3 762 patients were recruited to the department of urology, the first affiliated hospital of Nanjing medical university.All patients underwent a systematic 6-, 8-or 13-core biopsy, guided by finger or TRUS. The PCDR of different prostate specific antigen ( PSA) interval was analyzed.The PCDR of 6-or 8-core biopsy guided by finger and 13-core biopsy guided by TRUS were compared.The trends of PSA level, age and Gleason score in the patients with positive biopsy were summarized.Results A total of 3 762 patients underwent prostate biopsies and PCa were detected in 1479 patients (39.3%).Finger-guided 6-core biopsy was performed on 1 106 patients, and PCa were detected in 343 cases ( 31.0%) .Finger-guided 8-core biopsy was performed on 398 patients, and PCa were diagnosed in 144 cases (36.2%).Since 2009, 2 258 patients underwent TRUS-guided 13-core biopsy, and 992 ( 43.9%) were diagnosed as PCa, higher than that of finger-guided biopsies ( 43.9% vs.32.4%, P4 ng/ml) were lower than that of positive in digital rectal examination.The PCDR of 6 needles biopsy was higher in

  16. Contemporary outcomes in the detection of prostate cancer using transrectal ultrasound-guided 12-core biopsy in Singaporean men with elevated prostate specific antigen and/or abnormal digital rectal examination

    Directory of Open Access Journals (Sweden)

    Alvin Lee

    2015-10-01

    Conclusion: In conclusion, using contemporary 12-core biopsy methods, the local prostate cancer detection rate based on serum PSA and DRE findings has increased over the past decade presumably due to multiple genetic and environmental factors. Post-biopsy sepsis remains an important complication worldwide.

  17. 丁卡因胶浆在经直肠前列腺穿刺活检中的临床应用价值%Tetracaine Hydrochloride Jelly for clinical value during Transrectal Ultrasound guided biopsy of the prostate

    Institute of Scientific and Technical Information of China (English)

    邓晓俊; 刘辉; 刘峰; 王伟峰; 郝继东; 万建省; 刘波

    2014-01-01

    目的 比较患者在行经直肠前列腺穿刺活检术时,在直肠内及肛周使用丁卡因胶浆或单纯润滑剂,患者所经历的疼痛情况.方法 回顾性分析2011年1月至2013年1月120例行经直肠前列腺穿刺患者的临床资料.其中术中采用单纯性润滑剂患者60例(组Ⅰ),采用丁卡因胶浆患者60例(组2).采用水平视觉疼痛评分法评估患者经历的疼痛程度.结果 通过组间比较,两组患者疼痛程度与患者年龄、PSA水平、DRE是否异常、穿刺数目及术后并发症发生等均无统计学意义(P>0.05),当穿刺器械进入肛门时患者疼痛不适评分组1为2.8±1.8分,组2为1.3±1.6分(P=0.000<0.05),当行前列腺穿刺活检术时患者疼痛不适评分组1为5.5±1.7分,组2为3.3±1.5分(P=0.211 >0.05).结论 麻药制剂并不能增加经直肠前列腺穿刺活检术的安全性,但采用麻药制剂(如丁卡因胶浆)后可明显减轻穿刺所带给患者的疼痛不适.%Objectives The aim of this study was to compare the level of pain experienced by patients during TRUS-guided prostate biopsy using intrarectal 1% Tetracaine Hydrochloride Jelly versus Liquid paraffin.Methods 120 men using intrarectal 1% Tetracaine Hydrochloride Jelly versus Liquid paraffin in a protocol for prostate-cancer screening were analyzed.In this study we compared the pain and discomfort associated with prostate biopsy between two group of patient.Group 1 consists of 60men who received simple Liquid paraffin,and group 2 consists of 60 men who were given 1% Tetracaine Hydrochloride Jelly before the biopsy.Pain score measured by horizontal visual analogue scales.Results There were no statistical differences between the two groups in terms of age,serum PSA,DRE,TURS,biopsy core number and complications after biopsy(P > 0.05).The average pain score at the time of insertion of the ultrasound probe were 28 ± 1.8 and 1.3 ± 1.6 (P =0.000 < 0.05) and the average pain score at the time of taking biopsy were 5.5 ± 1.7and 3.3 ± 1.5 (P =0.211 > 0.05),respectively.Conclusions TRUS-guided prostate biopsy of the prostate can be safely whether or not anaesthesia in patients.But used 1% Tetracaine Hydrochloride Jelly in the rectal and perianal before TURS-guided prostate biopsy is an effective method for relieving biopsy-relate pain during the procedure.

  18. Rational scheme option of prostate biopsy guided by transrectal ultrasound%经直肠超声引导前列腺穿刺活检方案的合理选择

    Institute of Scientific and Technical Information of China (English)

    张步林; 胡兵

    2007-01-01

    经直肠超声(TRUS)引导前列腺穿刺活检是前列腺癌诊断和制定合理治疗方案的常规手段.制定扩大前列腺系统性穿刺方案时需综合考虑患者的年龄、前列腺体积及健康状况等因素.在系统性穿刺活检的基础上结合靶向性穿刺活检可提高前列腺癌的阳性率.

  19. A new method to measure the volume of unequable benign prostatic hypertrophy by transrectal ultrasonography%腔内超声测量不均匀增生前列腺体积新方法的探索

    Institute of Scientific and Technical Information of China (English)

    苏里亚; 杨扬; 王玉兰

    2005-01-01

    目的探索经直肠腔内超声(TRUS)准确测量不均匀增生前列腺体积的新方法.方法对比研究常规和本方法测量不均匀增生前列腺体积的差异.结果新方法所得值与不均匀增生前列腺实际重量之间的相关性良好,且优于常规方法.结论使用新方法更能反映不均匀增生前列腺的实际体积.

  20. 直肠超声下前列腺囊肿置管硬化治疗探讨%Catheterization for sclerosis therapy of prostate cyst guided By transrectal ultrasonography

    Institute of Scientific and Technical Information of China (English)

    王树松; 颜翠兰

    2002-01-01

    目的探讨直肠超声引导穿刺并置管在前列腺囊肿硬化治疗中的应用. 方法在直肠超声引导下,对前列腺囊肿进行穿刺置管,抽尽囊液、冲洗囊腔、注入无水酒精. 结果 21例均成功置管并进行硬化治疗.随访6月~18个月,21例囊肿均消失. 结论直肠超声引导穿刺前列腺囊肿准确可靠,置管硬化治疗方便、安全、有效.

  1. 经腹联合经直肠超声在前列腺中线囊肿诊断中的应用%Application of transabdominal and transrectal ultrasonography in diagnosis of midline prostatic cysts

    Institute of Scientific and Technical Information of China (English)

    廖森成; 何敏仪

    2014-01-01

    目的 探讨经腹超声(TAS)联合经直肠超声(TRUS)对前列腺中线囊肿的诊断价值.方法 根据检查方法将71例前列腺中线囊肿患者的资料分成两组,TRUS探查为对照组(30例),TAS+TRUS联合探查为观察组(41例),均经穿刺或病理证实,回顾分析并对比两组诊断符合率.结果 观察组对是否与精道相通、伴随征象及并发症的检出能力高于对照组,两组的超声诊断符合率差异有统计学意义(P<0.05).结论 TAS+TRUS联合探查较单纯使用TRUS在前列腺中线囊肿诊断时更加准确、全面.

  2. Diagnostic value of transrectal ultrasound for obstructive azoospermia induced by midline prostatic cysts%前列腺中线囊肿所致梗阻性无精子症的经直肠超声诊断价值

    Institute of Scientific and Technical Information of China (English)

    严剑波

    2013-01-01

    目的:探讨前列腺中线囊肿所致梗阻性无精子症的经直肠超声(TRus)诊断价值.方法:回顾性分析9例前列腺中线囊肿所致梗阻性无精子症患者的临床资料,及TRUS声像图表现.结果:9例无精子症患者精液量0.6~1.7 mL,pH值5.3~7.0,睾丸体积13~19 mL.其中,苗勒管囊肿4例,射精管囊肿2例,不能明确性质者3例.伴有精囊腺扩张者2例,精囊发育不全者1例.精囊炎1例.结论:利用TRUS检查前列腺中线囊肿准确而敏感,是现代影像学诊断前列腺中线囊肿所致梗阻性无精子症的理想方法.

  3. Value of Transrectal Ultrasonography in the Diagnosis of Midline Prostatic Cysts%经直肠超声检查对前列腺中线囊肿的诊断价值

    Institute of Scientific and Technical Information of China (English)

    罗彬; 戴宇平; 王道虎; 罗道升; 邓春华; 吴荣佩

    2008-01-01

    目的:探讨经直肠超声在诊断前列腺中线囊肿中的价值.方法:回顾性分析87例前列腺中线囊肿的经直肠超声的表现.结果:经直肠超声法诊断前列腺中线囊肿87例患者,其中,苗勒管囊肿33例,射精管囊肿21例,不能明确性质者33例.伴有精囊腺扩张者19例,精囊缺如或发育不全者19例,精囊炎9例,射精管扩张5例.结论:经直肠超声简便、准确、安全、无创,是诊断前列腺中线囊肿的理想方法.

  4. Value of diagnosis and treatment for patients with cysts around prostate by transrectal ultrasonography%经直肠超声对前列腺周围囊性病变的诊断与治疗的评估

    Institute of Scientific and Technical Information of China (English)

    陈文卫; 赵玉荣; 石华; 孙彬; 张玉国; 龙文; 胡云飞; 孙有刚

    2007-01-01

    目的 探讨经直肠超声对前列腺周围囊肿诊断与治疗的临床意义.方法 65例前列腺周围囊肿患者均行经直肠穿刺,获取囊液并分别给予硬化治疗和抗感染治疗.结果 先天性囊肿较大且囊液大多清亮,细胞数较少.除非合并其他生殖畸形,对男性生殖影响较少;后天性囊肿多源于感染,囊液内细胞数较多,对生殖尤其是精液、精子影响明显,经直肠超声结合介入治疗对前列腺周围囊肿有较好效果,有效率可达78.46%.结论 经直肠超声结合介入治疗是评价前列腺周围囊肿性质及治疗的方法之一.

  5. Fisher criteria vs. thyroid aspiration citology in the diagnosis of hashimoto's thyroiditis Valor de cuatro de los criterios de Fischer comarados con la biopsia tiroidea por aspiración en el diagnóstico de la tiroiditis de Hashimoto

    OpenAIRE

    Constanza Díaz González; Arturo Orrego; Mauricio Orrego; John J. Orrego

    1991-01-01

    One hundred and forty one patients with diffuse goiter were studied In order to evaluate four of Fisher's criteria for the diagnosis of Hashimoto's thyroiditis and to compare them with the result of thyroid aspiration biopsy. The following criteria were Included in the analysis: a) physical characteristics of the gland; b) appearance of the radioisotope scan; c) plasma TSH concentration; d) serum tilters of anti...

  6. Evaluation of WGA and Concanavalin A (Con A lectin as biomarkers of hepatosplenic schistosomiasis in human biopsies with no evidence of egg-granuloma system Avaliação das lectinas WGA e Con A como biomarcadoras de esquistossomose hepatoesplênica em biopsias humanas sem evidência do sistema ovo-granuloma

    Directory of Open Access Journals (Sweden)

    Moacyr Jesus Barreto de Melo Rêgo

    2013-06-01

    Full Text Available Introduction: Colonic lesions are predominant in patients with schistosomiasis. However, carbohydrate alterations in colonic schistosomiasis remain unclear. Lectin-ligands allow us to identify changes in the saccharide patterns of cells. Methods: Biopsies of descending and rectosigmoid colon of patients were submitted to WGA and Con A lectin histochemistry. Results: WGA stained stroma and gland cells of descending colon and rectosigmoid tissues in a granular strong cytoplasmatic pattern in schistosomiasis specimens differing from normal control and Con A failing to recognize all samples analyzed. Conclusions: WGA ligands are expressed differently in patients with hepatosplenic schistosomiasis and no evidence of egg-granuloma system. Introdução: Lesões do cólon são predominantes em pacientes com esquistossomose, entretanto alterações dos carboidratos no cólon com esquistossomose permanecem desconhecidas. Ligantes de lectinas permitem a identificação das mudanças no padrão dos carboidratos celulares. Métodos: Biópsias do cólon descendente e sigmóide dos pacientes foram submetidas a histoquímica com as lectinas WGA e Con A. Resultados: WGA marcou o estroma dos tecidos das células glandulares do cólon descendente e sigmóide com um padrão citoplasmático intenso e granular em espécimes com esquistossomose diferindo do controle normal e da Con A, a qual não reconheceu nenhum tecido estudado. Cólon sem esquistossomose não apresentou marcação. Conclusões: ligantes de WGA são diferentemente expressos em pacientes com esquistossomose hepatoesplênica sem evidência de sistema ovo-granuloma.

  7. Sobre-expresión de la proteína p 16 en biopsias con diagnóstico de NIC I, positivas para Genoma de Papiloma Virus Humano. Instituto del Cáncer. SOLCA Cuenca-Ecuador. 2009-2010.

    OpenAIRE

    Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Palta González, Araceli Miroslava; Picón Coronel, María Gabriela

    2015-01-01

    Numerosos estudios mencionan que la sobreexpresión de la proteína p16, un marcador biológico que permite identificar lesiones preneoplásicas del epitelio exocervical, tendría una alta asociación con el Papiloma Virus Humano (HPV) de alto riesgo oncogénico. Es un estudio descriptivo correlacional cuyo objetivo fue establecer asociación de las Neoplasias Intraepiteliales Cervicales grado I (NIC I), HPV positivos, con la expresión del p16. Materiales, métodos y resultados: Es un estudio corre...

  8. Evaluación de la subestimación diagnóstica e incidencia en nódulos mamarios BI-RADS 3, 4 y 5 estudiadas mediante biopsia-core guiada por ecografía Evaluation of diagnostic underestimation and incidence in BI-RADS 3, 4 and 5 nodules studied by ultrasound- guided core biopsy.

    Directory of Open Access Journals (Sweden)

    María Paula Tiscornia

    2011-12-01

    Full Text Available Objetivos. Determinar retrospectivamente el índice de falsos negativos y el grado de subestimación de la punción con aguja gruesa eco-guiada de nódulos mamarios. Establecer la incidencia de las diferentes lesiones que se manifiestan como nódulos mamarios. Materiales y Métodos. Se estudiaron las punciones de nódulos mamarios desde enero del 2000 a septiembre del 2010. Las mismas fueron realizadas por un radiólogo con 10 años de experiencia y se utilizaron agujas de corte de 14-gauge y 10 cm de longitud. Para la guía ecográfica se usaron dos ecógrafos con transductores lineales de 5-12 MHz. Se punzaron lesiones de moderada y alta sospecha de malignidad (BI-RADS 4 y 5 y algunas lesiones probablemente benignas (BI-RADS 3. Se correlacionaron los hallazgos histológicos de la punción y de la cirugía para cada lesión. A los casos con resultado benigno que no fueron operados se les realizó un seguimiento clínico de entre uno y diez años. Resultados. Se realizaron 190 punciones. El índice de falsos negativos fue del 3%, la sensibilidad de 95% y la especificidad de 100% (VPP de 100% y VPN de 95%. Discusión. Hubo coincidencia entre los resultados de las punciones y la cirugía en un 94%. El índice de falsos negativos es aceptable en comparación con otros reportes donde varía entre 0 y 8%. Conclusiones. Este estudio indica que la punción con aguja de corte eco-guiada es un método válido, con alto grado de precisión y bajo índice de subestimación y falsos negativos para el diagnóstico de nódulos mamarios malignos y benignos. Esto fue comprobado mediante la escisión quirúrgica y/o el seguimiento clínico- imagenológico de las diferentes lesiones.Objectives. To retrospectively determine the false negatives rate and the extent of underestimation of ultrasound-guided core biopsy of breast nodules, and to determine the incidence of the various lesions presenting as breast nodules. Materials and Methods. We studied core biopsies of breast nodules from January 2000 to September 2010, performed by a radiologist with 10 years experience in breast imaging, using 14-gauge and 10-cm needles. For ultrasound guidance, two ultrasound machines with a 5-12 MHz linear transducer were used. Biopsied lesions had a moderate or high suspicion of malignancy (BI-RADS 4 and 5 and some were probably benign lesions (BI-RADS 3. Histological findings of core-biopsy were correlated with those of surgery for each lesion. Cases of benign lesions which had not been operated on underwent a 1- to 10-year clinical and radiological follow-up. Results. A total of 190 biopsies were performed. The false negative rate was 3%, sensitivity was 95% and specificity was 100% (PPV 100% and NPV 95%. Discussion. There was 94% consistency between core biopsy results and surgery. The false negative rate is acceptable as compared to other reports, where it ranges from 0 to 8%. Conclusions. This study indicates that ultrasound-guided core biopsy is a valid method, with a high degree of accuracy and a low rate of false negatives and underestimation, in the diagnosis malignant and benign of breast nodules. This has been confirmed by surgical excision and / or clinical and imaging follow-up of different lesions.

  9. Determinación molecular de herpesvirus en biopsias de piel de pacientes sometidos a trasplante de precursores hematopoyéticos. Posible relación en el desarrollo de la enfermedad injerto contra huésped cutánea

    OpenAIRE

    2016-01-01

    [ES]La enfermedad de injerto contra huésped es el resultado de la agresión inmunológica de los tejidos del paciente que recibe el injerto mediada por las linfocitos del donante que reconocen a dichos tejidos como elementos extraños. Para que se produzca la enfermedad de injerto contra huésped, es condición sine qua non un paciente inmunodeprimido y una transferencia de linfocitos activos de otro paciente, bien sea de precursores hematopoyéticos de sangre periférica, médul...

  10. Three-dimensional grayscale ultrasound: evaluation of prostate cancer compared with benign prostatic hyperplasia.

    NARCIS (Netherlands)

    Sedelaar, J.P.M.; Roermund, J.G. van; Leenders, G.L. van; Hulsbergen-van de Kaa, C.A.; Wijkstra, H.; Rosette, J.J.M.H.C. de la

    2001-01-01

    OBJECTIVES: To compare the accuracy of the detection, localization, and staging of prostate cancer using transrectal three-dimensional (3D) grayscale ultrasonography (3D-US) with conventional transrectal two-dimensional grayscale ultrasonography (2D-US). METHODS: Fifty patients with clinical localiz

  11. Novel contrast-enhanced ultrasound imaging in prostate cancer

    NARCIS (Netherlands)

    Smeenge, M.; Mischi, M.; Laguna Pes, M.P.; de la Rosette, J.J.M.C.H.; Wijkstra, H.

    2011-01-01

    The purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing. Although grayscale transrectal ultrasound is the standard method for prostate imaging, it lacks accur

  12. [Prostatic abscesses. A review].

    Science.gov (United States)

    Rabii, R; Rais, H; Joual, A; el Mrini, M; Benjelloun, S

    1999-01-01

    We review the literature to the diagnosis and therapeutic aspect of prostatic abscess. The prostatic abscess having become an uncommon disease. The diagnosis of prostatic abscess has been nearly made by transrectal ultrasound and computed tomography scan. The best diagnostic method is considered to be the transrectal ultrasound. The choice therapy was intravenous antibiotic, and drainage by ultrasound guided transperineal percutaneous puncture.

  13. Radiation dose to the patient and the radiologist while performing on chest computed tomography: a program of early diagnosis of lung cancer, biopsy and treatment simulation guided radiation oncologist breast cancer; Dosis de radiacion al paciente y al radiologo durante la realizacion de tomografia computarizada en torax: progrma de diagnostico precoz del cancer de pulmon, biopsia guiada y simulacion del tratamiento oncologo radioterapico del cancer de mama

    Energy Technology Data Exchange (ETDEWEB)

    Pastor Sanchis, V.; Martinez Sanchez, J. M.; Palma Copete, J. D.; Crispin Contreras, V.; Casal Zamorano, E.; Dolores Alemany, V. de los; Gonzalez Perez, V.; Gimeno Olmo, J.; Guardino de la Flor, C.

    2011-07-01

    In this paper we determine the equivalent dose received by the operator and patient lung biopsies using thermoluminescence dosimeters, are established recommendations that this dose is as low as possible. It also reviews the acquisition protocols in both CT scans in early diagnosis program cited as the acquisition of CT for treatment planning dosimetric radiation oncologist in breast cancer.

  14. The value of transrectal color Doppler ultrasound in diagnosis of prostate carcinoma with different Gleason scores%经直肠彩色多普勒超声对不同Gleason评分前列腺癌的诊断价值

    Institute of Scientific and Technical Information of China (English)

    陈寒冰; 马麒; 方军初

    2010-01-01

    目的 探讨经直肠彩色多普勒超声(TRUS)对不同Gleason评分前列腺癌(PCa)的诊断价值.方法 对69例PCa结节与99例前列腺增牛结节患者采用TRUS榆查,记录结节内部血流丰富程度,并测量动脉血流收缩期最大血流速度(Vs)和阻力指数(RI).比较不同Gleason评分PCa结节与增生结节的Vs及RI.结果 PCa结节的血流丰富程度高于增生结节(P<0.05);PCa结节与增牛结节组间Vs、RI差异无统计学意义(P>0.05);Gleason评分高危组PCa结节的RI值显著高于增生结节(P<0.05).结论 频谱多普勒参数Vs、RI不能有效鉴别前列腺结节的良恶性.但当结节内血流的RI值明显增高时,应考虑Gleason评分高危组的PCa可能.

  15. Comparison of transrectal ultrasonography guided percutaneous sclerosing and drug-injection for prostatic cysts%经直肠超声引导穿刺硬化与注药治疗前列腺囊肿的疗效对比

    Institute of Scientific and Technical Information of China (English)

    白建宁; 钱毅; 郭莉; 张大勇; 单西云; 周璇奕; 李建文; 李建益; 郭亮; 麦海浪

    2010-01-01

    目的 探讨经直肠超声引导穿刺硬化与注药治疗前列腺囊肿的疗效及临床应用价值.方法 将28例前列腺囊肿患者平均分为2组,分别进行经直肠超声引导穿刺硬化治疗(硬化组)和注药治疗(注药组).比较两组的一次穿刺有效率及18个月后的复发率.结果 硬化组12例患者一次穿刺硬化治疗后囊肿显著减小,症状消失,一次硬化治疗有效率为85.71%(12/14);注药组11例一次穿刺注药治疗后囊肿显著减小,症状消失,一次注药治疗有效率为78.57%(11/14),两组一次穿刺治疗有效率差异无统计学意义(P=0.648).随访18个月,硬化组1例(7.14%,1/14)复发,注药组4例(28.57%,4/14)复发,两组复发率差异无统计学意义(P=0.328).结论 经直肠超声引导穿刺前列腺囊肿准确可靠,硬化治疗与注药治疗均具有较高的临床应用价值.

  16. Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism

    NARCIS (Netherlands)

    R. Kranse (Ries); R. van Mastrigt (Ron); F.H. Schröder (Fritz); J.L.H.R. Bosch (Ruud)

    1995-01-01

    textabstractIn an attempt to increase our understanding of the clinical syndrome of benign prostatic hyperplasia (BPH) an analysis was made of the association between prostate volume as measured by transrectal ultrasound and several reported urodynamically determined urethral resis

  17. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... three types of pelvic ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently ... pelvic ultrasound: abdominal ( transabdominal ) vaginal ( transvaginal / endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam ...

  18. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently used to evaluate the ... vaginal ( transvaginal / endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam may be part of ...

  19. Prostate Ultrasound

    Medline Plus

    Full Text Available ... uses sound waves to produce pictures of a man’s prostate gland and to help diagnose symptoms such ... also called transrectal ultrasound, provides images of a man's prostate gland and surrounding tissue. The exam typically ...

  20. Ultrasound -- Pelvis

    Medline Plus

    Full Text Available ... ultrasound: abdominal, vaginal (for women), and rectal (for men). These exams are frequently used to evaluate the ... vaginal ( transvaginal , endovaginal ) for women rectal ( transrectal ) for men A Doppler ultrasound exam may be part of ...

  1. Prostate Ultrasound

    Medline Plus

    Full Text Available ... as detailed as with the transrectal probe. An MRI of the pelvis may be obtained as an ... Benign Prostatic Hyperplasia (BPH) Prostate Cancer Ultrasound- and MRI-Guided Prostate Biopsy Images related to Ultrasound - Prostate ...

  2. Metabolism of adrenal androgen and its impacts on prostate cancer after castration

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ With the extensive utilization of PSA,digital rectum examination and transrectal ultrasound for screening in the aging population,the diagnosis of prostate cancer in China has markedly increased during the past years,particularly in developed regions.

  3. Prostate Ultrasound

    Medline Plus

    Full Text Available ... Prostate Ultrasound Imaging? What is Ultrasound Imaging of the Prostate? Ultrasound is safe and painless, and produces ... of page What are some common uses of the procedure? A transrectal ultrasound of the prostate gland ...

  4. [Resident of emergency attitude towards patients-physician relationship at the Hospital de Clínicas- Asunción, Paraguay].

    Science.gov (United States)

    Silvero, R A; Aranda, G R; Cristaldo, R; Recalde, M E; Arias, R; Presentado, D; Patiño, D; Acosta, A A; Apuril, E S; Hidalgo, D; Capurro, M H

    2015-01-01

    Se estudiaron retrospectivamente pacientes con diagnóstico de lupus eritematoso sistémico (LES) de acuerdo a criterios ACR 1982, con nefritis lúpica (NL) durante el período comprendido desde 2005 al 2012 y que fueran sometidos a una biopsia renal repetida. El número total de pacientes con NL atendidos fue de 120, de los cuales 18 (15%) pacientes fueron sometidos a biopsia renal repetida, 18 con 2 biopsias renales y 6 con 3 biopsias. 3 (16,7%) de los pacientes fueron fumadores; 1 (5,6%) poseía antecedentes de DBT previa, 2 (11,1%) poseían antecedentes de HTA; y 3 (16,7%) pacientes tenían obesidad previa. El tiempo de diagnóstico de LES al momento del estudio fue de 96 meses ± 15; el tiempo transcurrido entre la 1° y la 2° biopsia fue de 45 ± 11 meses y el tiempo entre la 2° y 3° biopsia fue de 56 ± 12 meses. Las indicaciones de la biopsia repetida fueron proteinuria en 10 biopsias (41,6%); proteinuria con alteración de la función renal en 2 biopsias (8,3%); proteinuria con sedimento patológico en 8 biopsias (33,3%); y proteinuria con sedimento patológico y alteración de la función renal en 4 biopsias (16,6%). Los cambios histológicos más frecuentes encontrados entre las primeras y las biopsias repetidas fueron: de clase IV a clase III: 2 (8,2%); clase IV a clase IV: 8 (33,3%), clase IV a clase III+V: 2 (8,2%); clase IV a clase IV+V: 3 (12,5%); clase IV a clase V: 2 (8,2%). Los cambios en las biopsias de NL proliferativas con índices de actividad y cronicidad (A/C) fueron: de A a A/C: 7 (29,1%), A/C a A/C: 7 (29,1%). La intensidad de la terapia inmunosupresora aumentó en 79,1%, se mantuvo el tratamiento inmunosupresor en 16.6%. Con respecto al cambio de medicación 7 (20%) pacientes recibieron Ciclofosfamida 1 gr cada 30 días, 9 (26%) Ciclofosfamida 500 mg cada 15 días, 8 (23%) tratamiento de reinducción con Micofenolato mofetil; Rituximab 8 (23%); y 3 (8%) Ciclosporina A. El tratamiento de mantenimiento se realizó con micofenolato

  5. Paracoccidioidomicosis perianal asociada a lepra lepromatosa: Presentación de un caso clínico Perianal paracoccidioidomycosis associated with lepromatous leprosy: A clinical case report

    OpenAIRE

    2008-01-01

    Se presenta el caso de un paciente alcoholista con una ulceración perianal y manifestaciones cutáneas de enfermedad de Hansen. La biopsia de la lesión perianal y otros estudios arribaron al diagnóstico de una forma diseminada de paracoccidioidomicosis, así como también las biopsias cutáneas y los estudios baciloscópicos fueron diagnósticos de lepra lepromatosa. La respuesta a la terapéutica fue satisfactoria con desaparición de las lesiones cutáneas. La disminución de la respuesta inmunológic...

  6. Concordancia entre histología pre, intra y postoperatoria en cáncer de endometrio

    OpenAIRE

    Serman V.,Felipe; Sánchez A,María Elena; Barrientos F,Bárbara; Saldaña G,Bárbara; Trullen S,Javier; Burky A,Daniela; Calvo S,Paula; Matus I,Maritza; Walton L,Roderick

    2012-01-01

    Antecedentes: En pacientes con cáncer de endometrio se discute la concordancia entre biopsia pre e intraoperatoria versus la definitiva, en grado de diferenciación, tipo histológico y profundidad de mioinvasión. Método: Se determinó sensibilidad (S), especificidad (E), valor predictivo positivo (VPP) y valor predictivo negativo (VPN) de: grado de diferenciación bien diferenciado y tipo histológico sólo endometrioide en biopsia preoperatoria; y grado de diferenciación bien diferenciado, tipo h...

  7. Detección del virus del papiloma humano en lesiones precancerosas y cancerosas de la mucosa bucal : Evaluación de diferentes métodos, diagnósticos y de técnicas de obtencion del material. Asociación de los resultados con otros factores carcinogénicos

    OpenAIRE

    Benitez, Mónica Beatriz

    2014-01-01

    Antecedentes: Varios estudios epidemiológicos han demostrado una amplia variación en el predominio del HPV en lesiones precancerosas y cancerosas bucales. Métodos: Las biopsias y las citologías por raspado de lesiones bucales premalignas y malignas, fueron evaluadas para detectar el DNA de HPV por el análisis PCR- Southern-Blot. Resultados: En 22 pacientes estudiados el 45,45 por ciento de las biopsias resultaron positivos para la detección de DNA-HPV, mientras que el 95-100 por ciento de las...

  8. LIQUEN SIMPLE CRÓNICO VULVAR UNILATERAL

    OpenAIRE

    Lema C,Rodrigo; Ricci A,Paolo; Solà D,Vicente; Contreras M,Luis

    2006-01-01

    Presentamos un caso de liquen simple crónico vulvar izquierdo, en una paciente con diagnóstico psiquiátrico de trastorno bipolar, tratado repetidamente como micosis. Se realizó biopsia que confirmó el diagnóstico y se trató exitosamente con antihistamínicos orales y corticoides tópicos

  9. Sonographic management of mediastinal syndrome.

    Science.gov (United States)

    Caremani, M; Benci, A; Tacconi, D; Occhini, U; Lapini, L; Caremani, A

    2009-06-01

    Sommario INTRODUZIONE: La diagnosi di sindrome mediastinica viene sospettata dai sintomi e confermata da una radiografia standard del torace ed ancor meglio dalla TC, ma anche l'ecografia con e senza mezzo di contrasto (CEUS) può essere utile in questa emergenza ematologica, permettendo oltre tutto una diagnosi istologica tramite biopsia ecoguidata. MATERIALI E METODI: 15 pazienti affetti da sindrome mediastinica sono stati prospetticamente studiati sia con l'ecografia B-Mode che utilizzando la CEUS. 13 di questi pazienti, senza altre lesioni sono stati proposti per una biopsia ecoguidata della massa mediastinica, che è stata tecnicamente possibile solo in 12. RISULTATI: L'ecografia B-mode mostra in questo lavoro un'ottima sensibilità (100%), nell'evidenziare le lesioni, ma una bassa specificità che non supera il 30–40%. La CEUS mostra invece una buona specificità per le patologie neoplastiche se viene valutata sia la fase precoce che quella tardiva (90–86,6%). La biopsia ecoguidata è stata possibile nel 92,3%, mostrando un'adeguatezza diagnostica del 91,66%. CONCLUSIONI: L'ecografia B-Mode, associata all'ecografia con mdc ed alla biopsia ecoguidata delle masse mediastiniche, ha un'elevata accuratezza nella diagnosi delle masse mediastiniche, che se confermata da ulteriori lavori, può trovare indicazione nel management della sindrome mediastinica.

  10. Carcinoma de células escamosas intraóseo primario derivado de un tumor odontogénico queratoquístico: reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Marcelo Mardones

    2014-04-01

    Se describen las características clínicas, radiológicas e histológicas, discutiendo la importancia de tomar biopsia de distintas zonas de una lesión quística caracterizada por afectar amplias zonas de los huesos maxilares.

  11. Occurrence of infection following prostate biopsy procedures in Japan: Japanese Research Group for Urinary Tract Infection (JRGU) - a multi-center retrospective study.

    Science.gov (United States)

    Togo, Yoshikazu; Kubo, Tatsuhiko; Taoka, Rikiya; Hiyama, Yoshiki; Uehara, Teruhisa; Hashimoto, Jiroh; Kurimura, Yuichiro; Takahashi, Satoshi; Tsukamoto, Taiji; Miyazaki, Jun; Nishiyama, Hiroyuki; Kira, Shinichiro; Kiyota, Hiroshi; Yazawa, Satoshi; Niwa, Naoya; Hongo, Hiroshi; Oya, Mototsugu; Kato, Taku; Yasuda, Mitsuru; Deguchi, Takashi; Ishikawa, Kiyohito; Hoshinaga, Kiyotaka; Matsumoto, Minori; Shigemura, Katsumi; Tanaka, Kazushi; Arakawa, Soichi; Fujisawa, Masato; Wada, Koichiro; Uehara, Shinya; Watanabe, Toyohiko; Kumon, Hiromi; Kobayashi, Kanao; Matsubara, Akio; Matsumoto, Masahiro; Sho, Takehiko; Hamasuna, Ryoichi; Matsumoto, Tetsuro; Hayami, Hiroshi; Nakagawa, Masayuki; Yamamoto, Shingo

    2014-04-01

    We retrospectively investigated the incidence of genitourinary tract infection in 5895 patients who underwent transrectal and/or transperineal prostate biopsy procedure between January and December 2011 at 46 institutions belonging to Japanese Research Group for Urinary Tract Infection (JRGU). The total rate of genitourinary tract infection after prostate biopsy was 0.76%, while that following transrectal procedure was 0.83% and following transperineal procedure was 0.57%, which were not significantly different. In contrast, febrile infection associated with a fever (≥38 °C) occurred significantly more frequently after transrectal (0.71%) than transperineal (0.16%) approach (P = 0.04). Notably, in infectious cases, Escherichia coli was most frequently isolated. Of the 9 E. coli strains isolated by urine culture, 6 (66.7%) produced extended spectrum β-lactamase (ESBL) and 7 (77.8%) showed levofloxacin resistance. Similarly, of 6 E. coli strains isolated by blood culture, 4 (66.7%) produced ESBL and 6 (100%) showed levofloxacin resistance. When the efficacy of antimicrobial prophylaxis (AMP) with levofloxacin for the patients undergoing transrectal or transperineal biopsy was compared between a single dose (500 mg) and that given for 2 or more days, no significant difference was observed for the rate of infection (transrectal: 0.82% vs. 1.04%, p = 0.94; transperineal: 0.30% vs. 0.46%, p = 0.68). Although a single dose of levofloxacin for AMP is sufficient to prevent genitourinary infection after transrectal or transperineal prostate biopsy, and recommended in this era of increased multi-drug resistant pathogens, the increase in fluoroquinolone-resistant E. coli and ESBL-producing E. coli has emerged as a profound problem for surveillance.

  12. Preparation and management of complications in prostate biopsies

    Directory of Open Access Journals (Sweden)

    Chiang Jeng Tyng

    2013-12-01

    Full Text Available Transrectal ultrasonography-guided biopsy plays a key role in prostate sampling for cancer detection. Among interventional procedures, it is one of the most frequent procedures performed by radiologists. Despite the safety and low morbidity of such procedure, possible complications should be promptly assessed and treated. The standardization of protocols and of preprocedural preparation is aimed at minimizing complications as well as expediting their management. The authors have made a literature review describing the possible complications related to transrectal ultrasonography-guided prostate biopsy, and discuss their management and guidance to reduce the incidence of such complications.

  13. [Combined therapy of voiding irritative disorders after surgical treatment of benign prostatic hyperplasia with Andro-Gin].

    Science.gov (United States)

    Loran, O B; Luk'ianov, I V; Markov, A V

    2005-01-01

    The results of operative and rehabilitative treatment of benign prostatic hyperplasia (BPH) was analysed for 69 BPH patients with postoperative irritative disorders of voiding. The patients were divided into four groups by rehabilitative therapy: group 1 received antibacterial therapy; group 2--antibacterial therapy+alpha-adrenoblockers; group 3--antibacterial therapy+transrectal laser and magnetic physiotherapy; group 4--antibacterial therapy+alpha-adrenoblockers+transrectal laser and magnetic physiotherapy. The worst result was obtained in group 1, the best one in groups 3 and 4 (the response was compatible). Thus, the addition of physiotherapy to the complex of postoperative rehabilitation of patients operated for BPH is justified and provides treatment improvement.

  14. In vivo testing of laser optoacoustic system for image-guided biopsy of prostate

    Science.gov (United States)

    Oraevsky, Alexander; Ermilov, Sergey; Mehta, Ketan; Miller, Tom; Bell, Brent; Orihuela, Eduardo; Motamedi, Massoud

    2006-02-01

    We have developed and used a laser optoacoustic imaging system with transrectal probe (LOIS-P) for detection of mechanical lesions in canine prostates in vivo. LOIS images have been acquired with a 128-channel transrectal probe and a 32-channel data acquisition system. Optoacoustic images showed a strong contrast enhancement for a blood containing lesion, when compared with ultrasound images. Our studies demonstrated that sufficient optoacoustic contrast exists between blood containing lesion and prostate tissue, although the lesion has been undetectable with ultrasound. The imaging results have been compared with visual examination of surgically excised prostates. Although axial resolution of the wide-band transducers employed in the transrectal probe provides good axial resolution of 0.5 mm, the convex arc geometry of the this array of transducers provides lateral resolution degrading with depth in tissue. A two step algorithm has been developed to improve the lateral resolution of deeply located objects. This algorithm employs optoacoustic image reconstruction based on radial back-projection to determine location and shape of the target object, then a procedure, we call Maximum Angular Amplitude Probability (MAAP), to determine true brightness of the object and simultaneously remove arc-shaped artifacts associated with radial back-projection. A laser optoacoustic imaging system (LOIS-P) with transrectal probe operating in backward detection mode empowered with the new image reconstruction algorithm seems promising as a modality for detection of prostate cancer and guiding prostate biopsy.

  15. Effect of alternate day collection on semen quality of Asian elephants (Elephas maximus) with poor initial fresh semen quality

    NARCIS (Netherlands)

    Imrat, P.; Mahasawangkul, Sittidet; Thitaram, Chatchote; Suthanmapinanth, P.; Kornkaewrat, K.; Sombutputorn, P.; Jansittiwate, S.; Thongtip, Nikorn; Pinyopummin, A.; Colenbrander, B.; Holt, W.V.; Stout, Tom

    2014-01-01

    In captivity, male Asian elephants often yield poor quality semen after transrectal manually assisted semen collection; however, the reasons for the disappointing semen quality are not clear. Here we test the hypothesis that accumulation of senescent spermatozoa is a contributory factor, and that se

  16. Ultrasound Imaging of the Pelvic Floor: linking anatomical findings with clinical symtoms

    NARCIS (Netherlands)

    A.B. Steensma (Anneke)

    2009-01-01

    textabstractFor evaluation of pelvic floor and lower urinary tract dysfunction the use of transabdominal ultrasound was first documented in the early eighties, with the translabial [1], transrectal [2] and transvaginal [3, 4] techniques developing somewhat later. To obtain a translabial or transperi

  17. Initial experience with identifying high-grade prostate cancer using diffusion-weighted MR imaging (DWI) in patients with a Gleason score

    NARCIS (Netherlands)

    Somford, D.M.; Hambrock, T.; Hulsbergen- van de Kaa, C.A.; Futterer, J.J.; Oort, I.M. van; Basten, J.P. van; Karthaus, H.F.M.; Witjes, J.A.; Barentsz, J.O.

    2012-01-01

    INTRODUCTION: Diffusion-weighted magnetic resonance (MR) imaging (DWI) might be able to fulfill the need to accurately identify high-grade prostate carcinoma, in patients initially selected for active surveillance in the Prostate Specific Antigen (PSA) screening era based on transrectal ultrasound-g

  18. Leiomyoma of the seminal vesicles: laparoscopic excision.

    Science.gov (United States)

    Casado Varela, Javier; Hermida Gutiérrez, Juan Francisco; Castillón Vela, Ignacio T; León Rueda, Maria Eugenia; Ortega Medina, Luis; Moreno Sierra, Jesús

    2014-01-01

    Leiomyoma of the seminal vesicles is an extremely rare type of benign tumor of the genitourinary system and can cause lower urinary tract symptoms. Despite their low incidence, these tumors can be identified with transrectal ultrasound of the seminal vesicles during prostate examination. The removal of these tumors is facilitated by a laparoscopic approach.

  19. Post-prostate biopsy infection with Escherichia coli ST131 leading to epididymo-orchitis and meningitis caused by Gram-negative bacilli.

    Science.gov (United States)

    Assimacopoulos, Aris; Johnston, Brian; Clabots, Connie; Johnson, James R

    2012-12-01

    A 57-year-old man who had recently undergone a transrectal prostate biopsy for a rising prostate-specific antigen level developed postbiopsy necrotizing epididymo-orchitis (requiring orchiectomy) and then Gram-negative meningitis, despite fluoroquinolone administration for periprocedural prophylaxis and subsequent therapy. The causative organism proved to be a fluoroquinolone-resistant Escherichia coli strain from sequence type ST131.

  20. MRI of the prostate: potential role of robots

    NARCIS (Netherlands)

    Fütterer, Jurgen J.; Misra, Sarthak; Macura, Katarzyna J.

    2010-01-01

    Prostate cancer is the most frequently diagnosed malignancy in the male population. Transrectal ultrasound- guided biopsy is still the imaging modality of choice in detecting prostate cancer. However, with prostate cancer being detected at an earlier stage, most prostate cancers tend to be isoechoic

  1. Pyometra and complete vaginal adhesion in a miniature horse

    Science.gov (United States)

    Cozens, Elizabeth R.W.

    2009-01-01

    A 4-year-old miniature horse experienced intermittent episodes of pyrexia, lethargy, and purulent vaginal discharge following dsytocia. Vaginal endoscopy and transrectal ultrasonography revealed a blind-ending vaginal cavity and distended uterus. Surgical treatment was declined and the mare was euthanized. Post-mortem examination confirmed the diagnosis of pyometra and vaginal adhesions. PMID:19949560

  2. Prostate biopsy with image fusion: system validation and clinical results (abstract)

    NARCIS (Netherlands)

    Kruecker, J.; Kadoury, S.; Xu, S.; Turkbey, B.; Choyke, P.; Pinto, P.; Wood, B.

    2011-01-01

    Purpose Prostate cancer (PCA) is the second most frequent cause of cancer-related death in men in the United States and Europe. Transrectal ultrasound (TRUS) guided systematic prostate biopsy is the standard of care for detection and diagnosis of PCA. However, due to inadequate visualization of PCA

  3. Reasons for the weak correlation between prostate volume and urethral resistance parameters in patients with prostatism

    NARCIS (Netherlands)

    J.L.H.R. Bosch (Ruud); R. Kranse (Ries); R. van Mastrigt (Ron); F.H. Schröder (Fritz); W.K. Mebust (W.)

    1995-01-01

    textabstractIn an attempt to increase our understanding of the clinical syndrome of benign prostatic hyperplasia (BPH) an analysis was made of the association between prostate volume as measured by transrectal ultrasound and several reported urodynamically determined urethral resistance parameters.

  4. In vitro fertilization (IVF) using semi-defined culture conditions from low or high antral follicle count pubertal beef heifers

    Science.gov (United States)

    To compare the in vitro fertilization (IVF) and production (IVP) of embryos from low and high antral follicle count (AFC) heifers, AFC were determined on 106 heifers using transrectal ultrasonography. Ten heifers with the lowest AFC (avg. 13.2) and 10 heifers with the highest AFC (avg. 27.4) with ev...

  5. High-risk prostate cancer: value of multi-modality 3T MRI-guided biopsies after previous negative biopsies

    NARCIS (Netherlands)

    Fütterer, J.J.; Verma, S.; Hambrock, T.; Yakar, D.; Barentsz, J.O.

    2012-01-01

    Transrectal ultrasound-guided biopsy is the gold standard for prostate cancer detection. The latter detection rates of random systematic TRUS-guided biopsy do not exceed 44\\%. As a consequence other biopsy methods have been explored. One of these methods is MR-guided biopsy (MRGB), which revealed de

  6. Utilidad de la elastografía de transición (Fibroscan® en la evaluación de la fibrosis hepática en pacientes con hepatopatía crónica

    Directory of Open Access Journals (Sweden)

    Daniel Álvarez

    2012-02-01

    Full Text Available El pronóstico de la enfermedad crónica hepática depende de la extensión y la progresión de la fibrosis hepática. Actualmente la biopsia hepática es la técnica de elección para determinar el grado de fibrosis, pero es una prueba invasiva, no exenta de complicaciones. Por ello, el desarrollo de marcadores no invasivos de fibrosis hepática se convirtió en una necesidad indiscutible. Se propuso la elastografìa por transición (Fibroscan® para valorar la fibrosis hepática en pacientes con enfermedad crónica hepática, mediante la medición de la rigidez hepática. Nuestro objetivo fue evaluar la efectividad, la objetividad y la seguridad de esta técnica. Se estudiaron 68 pacientes a los que se les realizó una biopsia hepática en los 18 meses previos al estudio. Todos los procedimientos de elastografia y biopsia hepática fueron analizados por un mismo profesional (DA y MA, respectivamente. Para la valoración de la biopsia hepática se utilizó la escala METAVIR. El valor medio de rigidez en pacientes sin fibrosis o con fibrosis leve (F0-F1 y en los pacientes con fibrosis avanzada o cirrosis (F3-F4 fue 6.8 ± 3.0 kPa y 21.0 ± 15.1 kPa, respectivamente (con diferencia significativa, p < 0.01. Las áreas debajo de la curva ROC definieron los niveles de corte en cada grupo. Con independencia del diagnóstico etiológico de enfermedad hepática, hallamos una correlación positiva, en todos los pacientes, entre rigidez hepática medida por elastografìa y grado de fibrosis hepática en la biopsia. En conclusión, podemos considerar que el Fibroscan® es un método no invasivo, seguro, fácil y rápido, que lo convierte en la alternativa a la biopsia para identificar fibrosis significativa o cirrosis.

  7. Renal arteriovenous fistula simulating hydronephrosis: A case report.

    Science.gov (United States)

    Lusenti, T; Fiorini, F; Barozzi, L

    2011-12-01

    Sommario INTRODUZIONE: Tra le fistole arterovenose (FAV) acquisite vi sono quelle che si formano quale complicanza dell’esecuzione di una biopsia renale. CASO CLINICO: Gli autori riportano il caso di una paziente giunta in ambulatorio di ecografia nefrologica per l’esecuzione di un’ecografia dei reni e delle vie urinarie per un’ipertensione sistolica di I grado di recente insorgenza. Negli esami di laboratorio era presente microematuria con proteinuria clinico-ecografico. DISCUSSIONE: Tra le malformazioni vascolari renali di non rara osservazione sono le FAV. Il caso descritto ribadisce l’importanza dell’impiego dell’eco color Doppler (ECD) nel sospetto di uropatia ostruttiva, per diagnosticare una FAV, specialmente nei pazienti già sottoposti a biopsia renale.

  8. Orbitotomía lateral mediante abordaje temporal Lateral orbitotomy using a temporal approach

    OpenAIRE

    H. Herencia Nieto; J.J. Verdaguer Martín; F. Riba García; J. Calvo de Mora Álvarez; A. del Amo Fernández de Velasco; R. Pujol Romanya; Navarro Cuéllar, C.

    2005-01-01

    La orbitotomía lateral sigue siendo en el momento actual la técnica quirúrgica de elección para la biopsia o extirpación de lesiones intraorbitarias laterales al nervio óptico, la biopsia del propio nervio óptico y la extirpación de la glándula lacrimal. Se han descrito múltiples incisiones cutáneas para llevar a cabo esta intervención; la más frecuentemente empleada por el momento es la incisión palpebral, que discurre a nivel de alguna arruga del párpado superior. Aunque los resultados obte...

  9. Caracterización de las fibras del músculo gluteus medius en equinos por métodos histoquímicos e inmunohistoquímicos Characterization of fibers from gluteus medius muscle in horses by histochemical and immunohistochemical methods

    OpenAIRE

    A Islas; M. QUEZADA; Mora, G.; J. L LÓPEZ-RIVERO; V. MERINO; Rojas, H; C Carrillo; M. ROJAS E; A. ZEGPIG

    2001-01-01

    Se tomó una biopsia a cuatro centímetros de profundidad en el músculo Gluteus medius de 16 equinos. Los animales tenían una edad promedio de 6 años y durante 3 meses previo a la toma de la biopsia no habían realizado entrenamiento. Las muestras fueron analizadas por medio de la técnica mATPasa miofibrilar, NADH-TR e inmuno-histoquímica. Los porcentajes de fibras tipo I, IIA, IIB oxidativas y no oxidativas fueron de un 14, 39, 30 y 17%, respectivamente, para la técnica histoquímica y un 16, 35...

  10. Hepatotoxicidad inducida por azatioprina en paciente con enfermedad de Crohn

    Directory of Open Access Journals (Sweden)

    D. Ruiz-Clavijo

    2013-08-01

    Full Text Available Los inmunosupresores se encuentran entre los grupos farmacológicos con mayor potencial teórico de inducir reacciones adversas, entre ellas las hepáticas. Presentamos el caso de un paciente de 35 años con enfermedad de Crohn en tratamiento con azatioprina por corticodependencia al que se le diagnosticó tras realización de una biopsia hepática de hiperplasia nodular regenerativa secundaria a este tratamiento.

  11. Perfil bioquímico del músculo Gluteus medius enequinos con distinto historial en carreras de resistencia Biochemical profile of the Gluteus medius muscle in horses with different performance records

    OpenAIRE

    1998-01-01

    El objetivo del estudio fue examinar las actividades de enzimas representativasde rutas metabólicas importantes del músculo esqueléticoen equinos de resistencia con diferente historial en competiciones, conel objeto de explicar si estas diferencias contribuyen a las diferenciasobservadas en el rendimiento funcional. Se obtuvieron biopsias a tres profundidadesdistintas (20, 40, 60 mm) del músculo Gluteus medius en 36equinos participantes en carreras de larga distancia de nivel nacionale intern...

  12. Sentinel node radioguided biopsy in surgical management of the medullary thyroid carcinoma A case report.

    Science.gov (United States)

    Boni, Giuseppe; Mazzarri, Sara; Grosso, Mariano; Manca, Giampiero; Biricotti, Marco; Ambrosini, Carlo Enrico; Fregoli, Lorenzo; Puccini, Marco; Caldarelli, Claudio; Spisni, Roberto

    2014-01-21

    Il carcinoma midollare della tiroide è raro. Il suo trattamento è chirurgico e consiste in una tiroidectomia totale associata a dissezione dei linfonodi centrali. L’opportunità della linfoadenectomia dei linfonodi cervicali laterali è argomento controverso. Per ridurre l’estensione della dissezione dei linfonodi laterocervicali ai casi in cui tale procedura sia effettivamente necessaria abbiamo eseguito la tecnica della biopsia del linfonodo sentinella, già praticata in altra patologia tumorale, in un caso di carcinoma midollare, sporadico, diagnosticato con ecografia, determinazione dei livelli di calcitonina serica e citologia dell’agoaspirato. All’ecografia non si evidenziavano linfonodi cervicali centrali o laterali. Abbiamo eseguito mappaggio preoperatorio dei linfonodi sentinella iniettando Tecnezio 99-m nel nodulo tiroideo. La paziente è stata poi sottoposta a tiroidectomia totale e biopsia radioguidata dei linfonodi sentinella. L’esame istologico ha confermato la presenza di un carcinoma midollare della tiroide e di micrometastasi in due linfonodi sentinella situati nel compartimento laterale destro. Dopo la tiroidectomia l’intervento è stato completato con dissezione dei compartimenti centrale e laterala destro. Al followup non sono stati rilevati livelli di calcitonina serica nè basali nè dopo stimolazione con pentagastrina. Si tratta del primo caso, riportato in letteratura, che dimostra l’utilità della biopsia radioguidata del linfonodo sentinella nella stadiazione linfonodale e del trattamento chirurgico del microcarcinoma midollare della tiroide. Tale biopsia può essere utile ad eseguire la dissezione linfonodale laterale solo nei pazienti con provato coinvolgimento dei linfonodi laterali del collo e quindi a ridurre l’entità della dissezione e delle relative complicanze.

  13. Tratamiento, mediante bloqueo de moléculas CD20 con Rituximab, en miopatías Inflamatorias Idiopáticas refractarias a tratamiento convencional

    OpenAIRE

    Chinchilla Palomares, Eduardo

    2012-01-01

    Las miopatías inflamatorias idiopáticas (MII) constituyen un grupo heterogéneo de enfermedades adquiridas, de probable mecanismo inflamatorio autoinmune, que se caracterizan por debilidad muscular e infiltrado inflamatorio local o difuso, junto con necrosis de las fibras musculares, en la biopsia muscular. Afectan preferentemente a la musculatura estriada. Dentro de este grupo se incluyen tres variantes principales: la dermatomiositis (DM), la polimiositis (PM) y la miositis con cuerpos de in...

  14. Cromoendoscopia com azul de metileno para diagnóstico de esôfago de Barrett

    Directory of Open Access Journals (Sweden)

    Saporiti Marcela Rocha Loures

    2003-01-01

    Full Text Available RACIONAL: O esôfago de Barrett é uma condição na qual a mucosa escamosa esofágica é substituída por metaplasia intestinal especializada, que predispõe o paciente ao desenvolvimento de adenocarcinoma esofágico. Este é precedido por displasia e carcinoma precoce; o rastreamento dessas lesões faz-se através de endoscopias digestivas periódicas com biopsias randomizadas. A incidência aumentada desse, tem despertado interesse no desenvolvimento de novas técnicas endoscópicas, como a cromoendoscopia com azul de metileno, para melhorar a identificação do esôfago de Barrett e suas complicações. OBJETIVO: Determinar se as biopsias dirigidas pela cromoendoscopia com azul de metileno oferecem vantagem em relação ao método convencional na detecção do esôfago de Barrett. MATERIAL E MÉTODO: Estudaram-se 45 pacientes com diagnóstico prévio de esôfago de Barrett, todos submetidos a dois exames de endoscopia digestiva alta com biopsias, em intervalo de 4 semanas, um convencional e outro com aplicação do corante, no período entre abril e outubro de 2002. RESULTADOS: Os resultados histológicos das biopsias de todos os exames foram comparados. Observou-se sensibilidade de 62,5%, especificidade de 15,4%, valor preditivo positivo de 57,7% e valor preditivo negativo de 18,2%. Não houve diferença significativa quanto ao número de biopsias. O tempo de duração da técnica de cromoendoscopia foi significativamente maior quando comparado ao da técnica convencional. CONCLUSÃO: Não se observou vantagem na utilização da cromoendoscopia em relação à técnica randomizada no diagnóstico do esôfago de Barrett.

  15. Comparación de métodos diagnósticos en la infección por Helicobacter pylori en Quindío, Colombia

    Directory of Open Access Journals (Sweden)

    José Ignacio Moncayo

    2006-09-01

    Full Text Available Introducción: El Helicobacter pylori es un bacilo gramnegativo que infecta la mucosa gástrica de más de la mitad de la población mundial; causa gastritis, enfermedad ulcero-péptica, y se asocia tanto con carcinoma gástrico como con linfoma gástrico (MALT. Objetivo: Comparar el índice de desempeño de los métodos de diagnóstico de rutina y la PCR para establecer por definición de caso la prevalencia de infección por H. pylori en pacientes con enfermedad acido-péptica en Quindío. Metodología: A 73 pacientes se les tomaron seis biopsias de cada uno, una antral para la PCR-ureC, tres para cultivo (antral, cuerpo y fondo gástricos, otra antral para prueba rápida de ureasa (PRU y ésta junto con una del cuerpo para el examen histológico. Se determinó el índice de desempeño de cada uno de los métodos. Para el diagnóstico decisivo de la infección se consideró como definición de caso (H. pylori positivo el cultivo positivo o la concordancia de por lo menos dos métodos de diagnósticos positivos (examen histológico, PRU y PCR. Resultados: El examen histológico del antro fue positivo en 79.5% (58/73 y en cuerpo 82.2% (60/73; la combinación de los resultados de las dos biopsias del estudio histológico fue 94.5% (69/73. Los cultivos de las tres biopsias mostraron idéntico resultado en 75.4% (55/73; la combinación de los resultados del cultivo en las tres biopsias fue 86.3% (63/73. La PRU en biopsia antral fue positiva en 79.5% (58/73 y la PCR-ureC de biopsia antral fue 86.3% (63/73. De acuerdo con la definición de caso la prevalencia de la infección por H. pylori fue 97.3 % (71/73. Al comparar los resultados de cada método frente al obtenido por definición de caso, el examen histológico, el cultivo, la PCR y PRU presentaron 2, 8, 8, y 13 falsos negativos, respectivamente, pero no hubo falsos positivos. Los índices de desempeño (ID para cada método fueron: Cultivo: ID, 78.1% y 88.7% de sensibilidad, resultado id

  16. Aborto en una yegua debido a mellizos, ¿porque conviene reducirlos manualmente?: reporte de un caso - Abortion in a Mare caused by twins pregnancy, the convenience of the manual reduction of one of the twins. A case report

    Directory of Open Access Journals (Sweden)

    González del Pino, Francisco Javier.

    2010-12-01

    Full Text Available ResumenEl artículo describe el caso clínico de un cuadro de aborto en un yegua deraza Peruano de Paso de 10 años de edad, debido a una preñez de mellizoscon fijación bicornual. La misma fue diagnosticada en forma precozmediante ecografía transrectal, pero su desenlace final en un abortoindeseable se debió a que el propietario del animal, no quiso su resoluciónmediante la técnica de reducción manual de uno de los mellizos.SummaryThis article describes a clinical case of an abortion in a 10 year old PeruvianPaso mare, caused by twin pregnancies bilaterally fixed. It was earlydiagnosed by transrectal ultrasound, but its final outcome in an unwantedabortion because the animal's owner declined to its resolution through thetechnique of manual reduction of one of the twins.

  17. Neuroendocrine carcinoma of the seminal vesicles presenting with Lambert Eaton syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Burger Maximilian

    2010-10-01

    Full Text Available Abstract Introduction Primary tumors of seminal vesicles are rare and only a few cases have been reported. Diagnosis is difficult due to the absence of early clinical signs. Prognosis is generally poor. Case presentation We present the case of a 70-year-old Caucasian man with a seminal vesicle mass and concomitant lymph node metastasis detected by computed tomography and body positron emission tomography/low-dose computed tomography scan carried out for evaluation of Lambert Eaton syndrome. Transrectal ultrasound-guided biopsy showed a poorly differented neuroendocrine carcinoma with an immunhistochemical profile similar to small cell lung cancer. Following chemotherapy the disease was stable and active surveillance was initiated. Conclusions Lambert Eaton syndrome may be the initial symptom of a seminal vesicle mass. Diagnosis needs to be obtained by transrectal biopsy and chemotherapy may delay progression of the tumor.

  18. Granulomatous prostatitis after intravesical immunotherapy mimicking prostate cancer.

    Science.gov (United States)

    Białek, Waldemar; Rudzki, Sławomir; Iberszer, Paweł; Wronecki, Lech

    2016-12-01

    Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented. Due to abnormalities found in rectal examination and an abnormal transrectal ultrasound image of the prostate with extensive infiltration mimicking neoplastic hyperplasia a core biopsy of the prostate was performed. Histopathological examination revealed inflammatory infiltration sites of tuberculosis origin.

  19. VERIFICATION OF A TUMOR LESION OF INTRAPELVIC LYMPH NODES AFTER RADICAL PROSTATECTOMY. THE FIRST EXPERIENCE

    Directory of Open Access Journals (Sweden)

    V. V. Kapustin

    2014-08-01

    Full Text Available Objective: to study the possibilities of transrectal ultrasound scan (TRUS and magnetic resonance imaging (MRI in identifying and verifying a tumor lesion of intrapelvic lymph nodes (LN in patients with biochemical recurrence after radical prostatectomy.Subjects and methods. Metastatic tumor lesion of intrapelvic LNs was verified in 4 patients by transrectal ultrasound (US-guided needle biopsies. All the patients underwent multi-parametric MRI studies and TRUS.Results. The application of current MRI technologies (for qualitative and quantitative analysis of diffusion-weighted images and for postcontrast sequences could detect and judge with confidence the metastatic lesion of intrapelvic LNs. TRUS permits clearly visualizing pathologically altered LNs, by taking into account their MRI pattern and verifying their tumor lesion by US-guided core needle biopsy.Conclusion. The combined use of multi-parametric MRI and TRUS provides a means for diagnosing and verifying the tumor lesion of pelvic LNs in patients after prostatectomy.

  20. VERIFICATION OF A TUMOR LESION OF INTRAPELVIC LYMPH NODES AFTER RADICAL PROSTATECTOMY. THE FIRST EXPERIENCE

    Directory of Open Access Journals (Sweden)

    V. V. Kapustin

    2012-01-01

    Full Text Available Objective: to study the possibilities of transrectal ultrasound scan (TRUS and magnetic resonance imaging (MRI in identifying and verifying a tumor lesion of intrapelvic lymph nodes (LN in patients with biochemical recurrence after radical prostatectomy.Subjects and methods. Metastatic tumor lesion of intrapelvic LNs was verified in 4 patients by transrectal ultrasound (US-guided needle biopsies. All the patients underwent multi-parametric MRI studies and TRUS.Results. The application of current MRI technologies (for qualitative and quantitative analysis of diffusion-weighted images and for postcontrast sequences could detect and judge with confidence the metastatic lesion of intrapelvic LNs. TRUS permits clearly visualizing pathologically altered LNs, by taking into account their MRI pattern and verifying their tumor lesion by US-guided core needle biopsy.Conclusion. The combined use of multi-parametric MRI and TRUS provides a means for diagnosing and verifying the tumor lesion of pelvic LNs in patients after prostatectomy.

  1. Clinicopathologic characteristics of anterior prostate cancer (APC), including correlation with previous biopsy pathology.

    Science.gov (United States)

    Magers, Martin J; Zhan, Tianyu; Udager, Aaron M; Wei, John T; Tomlins, Scott A; Wu, Angela J; Kunju, Lakshmi P; Lew, Madelyn; Feng, Felix Y; Hamstra, Daniel A; Siddiqui, Javed; Chinnaiyan, Arul M; Montgomery, Jeffrey S; Weizer, Alon Z; Morgan, Todd M; Hollenbeck, Brent K; Miller, David C; Palapattu, Ganesh S; Jiang, Hui; Mehra, Rohit

    2015-11-01

    Anterior-predominant prostate cancer (APC) is an incompletely understood entity which can be difficult to sample via transrectal biopsy. Seemingly favorable biopsy results may belie the potential aggressiveness of these tumors. Here, we attempt to characterize APC by retrospectively examining the clinicopathologic features of APC at radical prostatectomy and comparing our findings with prior biopsy information. We found that 17.4 % of patients in our study had APC. APC demonstrated a significantly lower (P value biopsy than non-transperineal saturation (i.e., transrectal ultrasound guided) biopsy strategies. Four patients (7 %) without transperineal saturation biopsy exhibited a significantly worse GS at RP than biopsy, compared to five patients (36 %) with transperineal saturation biopsy. Our findings corroborate the difficulty in detecting APC and suggest that APC is not a uniform disease with a wholly indolent phenotype. Dedicated long-term outcome data are needed in these patients. Additionally, alternative pathologic staging parameters may be necessary.

  2. Phyllodes tumor of the verumontanum: a case report.

    Science.gov (United States)

    Tang, Jin; He, Leye; Long, Zhi; Wei, Jingchao

    2015-06-16

    The current report presents the case of a 42-year-old male with extraordinarily salient urination difficulty that had lasted 6 months. Transrectal ultrasonography and pelvic magnetic resonance imaging demonstrated prostatic hyperplasia and cyst. PSA level was 20.65 (>4) μg/L in the patient. Transrectal prostatic biopsy revealed benign prostatic hyperplasia. He agreed to receive plasmakinetic resection of the prostate. During operation a lobulated lump was unexpectedly found on the verumontanum, with the prostate macroscopically normal. Complete tumor excision was performed and pathological assessment indicated phyllodes tumor of the verumontanum. The patient had an uneventful post-operative course and recovered well. The diagnosis, histological classification, treatment, and prognosis of this case are presented. It is necessary to perform cystoscopy to exclude verumontanum tumor even when all imaging examinations indicate prostate hyperplasia, especially in young males. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1868931661161758.

  3. The role of transperineal template biopsies of the prostate in the diagnosis of prostate cancer: a review.

    Science.gov (United States)

    Abdulmajed, Mohamed Ismat; Hughes, Daniel; Shergill, Iqbal Singh

    2015-03-01

    The incidence of prostate cancer has shown a significant increase, highlighting the importance of early diagnosis. Current practice considers histological diagnosis a necessity in the majority of the cases. The limitations of transrectal biopsies led to the development of the promising transperineal prostatic biopsies. The latter offers a safer approach by avoiding the rectum, utilizing brachytherapy template grid to detect anterior zone disease and provides accurate prostatic mapping by systematically sampling the whole gland. It also helps to direct biopsies based on images obtained from previous prostate scanning and identify those eligible for focal therapy to direct focal treatment accurately. The current literature provides enough reassurance that transperineal template biopsies are effective, efficient and superior to the traditional and inaccurate transrectal biopsies. The absence of consensus on the technical aspect of template biopsies is a drawback, yet it highlights the need to develop robust guidelines to standardize the procedure.

  4. Piezoelectric Composite Micromachined Multifrequency Transducers for High-Resolution, High-Contrast Ultrasound Imaging for Improved Prostate Cancer Assessment

    Science.gov (United States)

    2015-08-01

    Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 DISTRIBUTION STATEMENT: Approved for Public Release; Distribution Unlimited...SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick...a Siemens EV- 8C4 transrectal ultrasound probe. In the in-vivo study, molecular imaging and microvascular mapping will both be performed to assess

  5. The Prevalence and Characteristic Differences in Prostatic Calcification between Health Promotion Center and Urology Department Outpatients

    OpenAIRE

    Hong, Chan Gyu; Yoon, Byung Il; Choe, Hyun-Sop; Ha, U-Syn; Sohn, Dong Wan; Cho, Yong-Hyun

    2012-01-01

    Purpose We evaluated the differences in calculi characteristics and their prevalence according to the presence of lower urinary tract symptoms between adult patients examined at the Urology Department and those examined at the Health Promotion Center (HPC). Materials and Methods The prevalence of prostatic calcification, characteristics of calculi (number, size, and location), and differences in lower urinary tract symptoms were compared and analyzed for 479 subjects who underwent transrectal...

  6. Primary cryptococcal prostatitis--rare occurrence.

    Science.gov (United States)

    Shah, Vinaya B; Patil, Pallavi A; Agrawa, Vipul; Kaswan, Harish K

    2012-05-01

    Cryptococcosis is a well recognized infection in immunocompromised patients. Cryptococcal infection primarily involves the lung and is hematogeneously spread to other organs. Sometimes it might affect the genitourinary tract. The prostate gland is a rare site of primary infection due to cryptococcus neoformans. We report a case of granulomatous inflammation in the prostate as a result of crypyococcus neoformans infection in a 70 year old immunocompetent patient, a non diabetic, which was diagnosed by transrectal ultrasound guided biopsy.

  7. Role of 18F-FDG PET/CT in the staging of pediatric peritoneal mesothelioma.

    Science.gov (United States)

    Abikhzer, Gad; Gourevich, Konstantin; Arkovitz, Marc; Postovsky, Sergey; Keidar, Zohar

    2013-08-01

    A 7-year-old girl with a 1-month history of diffuse abdominal pain underwent an ultrasound which showed a pelvic mass with multiple peritoneal implants and ascites. An US-guided core biopsy of one of the implants as well as a transrectal biopsy of the pelvic tumor showed pathological findings consistent with epithelioid mesothelioma. We describe the findings on (18)F-FDG PET/CT in pediatric peritoneal mesothelioma.

  8. [Hemospermia].

    Science.gov (United States)

    Koutani, A; Joual, A; Herard, A

    1997-01-01

    Haemospermia is a relatively frequent symptom in urology, especially in young subjects. It is often benign, but is important because of the anxiety it can cause to the patient. The predominant aetiology of haemospermia is prostatic and seminal vesicle disease. Iatrogenic aetiologies, generally without severity, are due to the development of instrumental diagnosis and treatment in urology. Recent progress in the field of medical imaging, particularly transrectal ultrasonography and magnetic resonance imaging, has greatly contributed to the diagnostic and therapeutic approach to haemospermia.

  9. Experimental Study on the Effect of High-intensity Focused Ultrasound (HIFU) Using Sonablate-500 in the Ablation of Canine Prostate

    Institute of Scientific and Technical Information of China (English)

    LU Jun; YE Zhangqun; WANG Wei; CHEN Zhaoyang; ZHANG Yuanfeng; HU Weilie

    2007-01-01

    To investigate the safety, feasibility and effectiveness of transrectal high-intensity focused ultrasound (HIFU) in the ablation of canine prostate, 20 dogs were divided randomly into 5 groups.Sixteen canine prostates were treated with the third-generation transrectal HIFU device (Sonablate-500 TM). Transrectal ultrasound images of the prostate and prostatic urethra were observed preoperatively and postoperatively. Serial study was performed 30 min, 30 days, 60 days and 180 days after the therapy. The rectum, periprostatic tissues, and prostate were excised en bloc and the tissues were fixed for gross and histological analysis. Our results showed that the average maximal diameter of prostatic urethra was 0.59±0.11 cm before the operation and 2.57±0.98 cm 60 days after the operation. The volume of prostate was 6.5±3.12 cm3 before the treatment while the volume was 4.13±0.23 cm3 60 days after the treatment and the differences were statistically significant (P<0.05).Histologically, there was a clear demarcation between the necrotic area of the treated tissues and the unaffected surrounding tissues. All the necrotic tissues in the targeted zone broke off and the prostatic urethra became cavitary 60 days later. The more frequent complications were urinary retention and frequency and hematuria. No rectal injury occurred during the treatment. It is concluded that the third-generation transrectal HIFU is capable of destroying prostatic tissue, substantially increasing the width of the prostatic urethra without causing injury to the adjacent tissues. The risk of postoperative complications associated with HIFU was low. HIFU may become a safe, effective and minimally invasive alternative for the treatment of prostatic diseases..

  10. Dissemination of tuberculosis after biopsy of primary tubercular prostate: a case report

    OpenAIRE

    Onkar Jha; Vidya Nair; Deepak Talwar

    2015-01-01

    Only 15-20% of extrapulmonary tuberculosis (TB) has been attributed to TB of the urogenital system and often Results from haematogenous spread from an active site of infection. Isolated involvement of prostate by TB is relatively less common. The incidence of primary prostatic TB is unknown and in its truest sense is a very rare entity. Here, we report the case of a patient with primary prostatic TB who was misdiagnosed as nonspecific granulomatous inflammation on transrectal ultrasound-guid...

  11. TRUS, CT and MRI findings of hydatid disease of seminal vesicles

    Energy Technology Data Exchange (ETDEWEB)

    Saglam, M.; Tasar, M.; Bulakbasi, N.; Tayfun, C.; Somuncu, I. [Department of Diagnostic Radiology, Guelhane Military Medical Academy and Medical School, Ankara (Turkey)

    1998-07-01

    Hydatid disease of the urogenital system, especially seminal vesicles and prostate, or retroperitoneum is a very rare condition. Secondary dissemination of seminal vesicles has not been described before. We describe the transrectal ultrasonography (TRUS), CT and MRI findings of a secondary solitary hydatid cyst of the left seminal vesicle, in a patient with disseminated hydatid disease involving all abdominal organs except for right kidney. We obtained typical findings of hydatid cyst at all modalities. (orig.) With 3 figs., 11 refs.

  12. Haemospermia and 25 cases

    Directory of Open Access Journals (Sweden)

    Nikoubakht M

    1997-04-01

    Full Text Available During 3 years (1991-1994 25 cases were evaluated for hemospermia. 64% with primary management had improved. 36% that required more evaluation have at least one urologic problem in TRUS. Of these, adenocarcinoma of prostate, prostatic stone, seminal vesicle dilatation, each two cases, and verumontanum stone, urethral polyp, prostatic cyst each one case are diagnosed. According to this study the best method for evaluation of hemospermia is transrectal ultrasonography.

  13. Rectum separation in patients with cervical cancer for treatment planning in primary chemo-radiation

    OpenAIRE

    Marnitz Simone; Budach Volker; Weißer Friederike; Burova Elena; Gebauer Bernhard; Vercellino Filiberto; Köhler Christhardt

    2012-01-01

    Abstract Purpose To proof feasibility of hydrogel application in patients with advanced cervical cancer undergoing chemo-radiation in order to reduce rectal toxicity from external beam radiation as well as brachytherapy. Material and methods Under transrectal sonographic guidance five patients with proven cervical cancer underwent hydro gel (20 cc) instillation into the tip of rectovaginal septum adherent to posterior part of the visible cervical tumor. Five days after this procedure all pati...

  14. [Use of levofloxacin in the antibiotic prophylaxis for diagnostic procedures in urology].

    Science.gov (United States)

    Trinchieri, Alberto; Mangiarotti, Barbara; Lizzano, Renata

    2002-03-01

    Chemoprophylaxis is the use of antimicrobial agents before contamination in the hope of preventing infections. The need for prophylaxis depends on the type of procedure and the risk for each individual patient. The risk for infection from urethral catheterization in a hospital setting is 5% for men and 10-20% for women, after routine cystoscopy is 4.7%, after transurethral resection of the bladder (TURB) is 39%, after transurethral resection of the prostate (TURP) is 6-43%, after transrectal biopsy of the prostate is 6.2-87%, and after shock wave lithotripsy is 5.7%. On this basis prophylactic treatment is recommended in all patients for transrectal prostate biopsy and transurethral surgery and in patients with increased risk of infection for diagnostic endoscopy of the urinary tract and SWL. Risk factors such as age, immunosuppression, metabolic dysfunction (e.g., diabetes), reduced general condition, prolonged operative time and bleeding, should be considered. Broad-spectrum cephalosporin, penicillins and fluoroquinolones are most often used. The choice of the drug also depends on its pharmacokinetic properties that should secure effective tissue levels during the procedure. Levofloxacin meets these criteria and reduces the incidence of infection after transrectal prostate biopsy and endoscopy of the urinary tract.

  15. Endoscopic ultrasound for the characterization and staging of rectal cancer. Current state of the method. Technological advances and perspectives.

    Science.gov (United States)

    Gersak, Mariana M; Badea, Radu; Graur, Florin; Hajja, Nadim Al; Furcea, Luminita; Dudea, Sorin M

    2015-06-01

    Endoscopic ultrasound is the most accurate type of examination for the assessment of rectal tumors. Over the years, the method has advanced from gray-scale examination to intravenous contrast media administration and to different types of elastography. The multimodal approach of tumors (transrectal, transvaginal) is adapted to each case. 3D ultrasound is useful for spatial representation and precise measurement of tumor formations, using CT/MR image reconstruction; color elastography is useful for tumor characterization and staging; endoscopic ultrasound using intravenous contrast agents can help study the amount of contrast agent targeted at the level of the tumor formations and contrast wash-in/wash-out time, based on the curves displayed on the device. The transvaginal approach often allows better visualization of the tumor than the transrectal approach. Performing the procedure with the rectal ampulla distended with contrast agent may be seen as an optimization of the examination methodology. All these aspects are additional methods for gray-scale endoscopic ultrasound, capable of increasing diagnostic accuracy. This paper aims at reviewing the progress of transrectal and transvaginal ultrasound, generically called endoscopic ultrasound, for rectal tumor diagnosis and staging, with emphasis on the current state of the method and its development trends.

  16. Photoacoustic image-guided drug delivery in the prostate

    Science.gov (United States)

    Tang, Shanshan; Chen, Jian; Samant, Pratik; Xiang, Liangzhong

    2016-03-01

    Image guided drug delivery is a novel strategy that combines the effect of therapy and visibility into one system. Here we apply photoacoustic (PA) imaging to visualize the drug delivery process, and perform a simulation study on monitoring the photosensitizer concentration in a prostate tumor during photodynamic therapy (PDT). A 3D optical model of the human prostate is developed, and the light absorption distribution in the prostate is estimated by the Monte Carlo simulation method. The filtered back-projection algorithm is used to reconstruct PA images. PA images of transurethral laser/transrectal ultrasound are compared to those of transrectal laser/ultrasound. Results show that the transurethral laser has a better penetration depth in the prostate compared with transrectal one. Urethral thermal safety is investigated via COMSOL Multiphysics, and the results show that the proposed pulsed transurethral laser will cause no thermal damage on the urethral surface. Regression analysis for PA signal amplitude and drug concentration demonstrates that the PA technique has the potential to monitor drug distributions in PDT, as well as in other laser-based prostate therapy modalities.

  17. Uroflowmetry, trans rectal ultra sonography and power doppler to develop a less invasive bladder outlet obstruction score in benign prostatic hyperplasia: A prospective analysis

    Directory of Open Access Journals (Sweden)

    Rajiv Goyal

    2006-01-01

    Full Text Available OBJECTIVE : To evaluate the ability of transrectal power doppler sonography (TRPDS in combination with conventional grey scale transrectal ultrasonography (TRUS, uroflowmetry and clinical parameters, to predict bladder outlet obstruction (BOO in benign prostatic hyperplasia (BPH. MATERIALS AND METHODS : Sixty-nine male patients with more than 50 years of age, presenting with lower urinary tract symptoms were evaluated prospectively for BOO secondary to BPH. TRUS was done to estimate prostate volume (PV, transition zone volume (TZV, median lobe projection in the bladder (ML and bladder wall thickness (BWT. TRPDS was done to measure resistive index (RI of transition zone vessels. All patients also underwent PFS and depending upon its results, the patients were divided into Group 1 [Abram-Griffiths (AG number 40. Mean values of TRUS and TRPDS parameters and uroflowmetry in the two groups were compared to identify predictive factors for BOO. RESULTS : Demographic profile of Group 1 (n= 42 was similar to that of Group 2 (n= 27. Significant independent factors for prediction of BOO were maximum flow rate, resistive index of transition zone, median lobe projection into the bladder and post void residue. BOO scoring system was developed based on these 4 factors, which showed a specificity of 77.8% and a sensitivity of 85.7%, with an overall predictive value of 82.6%. CONCLUSIONS : Transrectal power doppler ultrasonography (resistive index in combination with uroflowmetry, median lobe projection in bladder and post void residue measurement can predict BOO with a high specificity and sensitivity.

  18. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori

    Directory of Open Access Journals (Sweden)

    Luis Eduardo Bravo

    2008-03-01

    Full Text Available Introducción: El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos: Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI, displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos: En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento.Resultados: La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9% y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0

  19. Fuentes de variabilidad en el diagnóstico de gastritis atrófica multifocal asociada con la infección por Helicobacter pylori1

    Science.gov (United States)

    Bravo, Luis Eduardo; Bravo, Juan Carlos; Realpe, José Luis; Zarama, Guillermo; Piazuelo, MarÍa Blanca; Correa, Pelayo

    2014-01-01

    RESUMEN Introducción El mapeo de las diferentes regiones del estómago y el número de fragmentos de mucosa gástrica disponibles para evaluación histopatológica son fuentes importantes de variación en el momento de clasificar y hacer la gradación de la gastritis crónica. Objetivos Estimar la sensibilidad del número de fragmentos de mucosa gástrica necesarios para establecer los diagnósticos de gastritis atrófica con metaplasia intestinal (MI), displasia y estado de infección por Helicobacter pylori. Además evaluar la variabilidad intra-observador en la clasificación de estas lesiones precursoras del cáncer gástrico. Materiales y métodos En una cohorte de 6 años de seguimiento se evaluaron 1,958 procedimientos de endoscopia realizados por dos gastroenterólogos. En cada procedimiento y de cada participante se obtuvieron 5 biopsias de mucosa gástrica que representaban antro, incisura angularis y cuerpo. Un único patólogo hizo la interpretación histológica de las 5 biopsias y proporcionó un diagnóstico definitivo global que se utilizó como patrón de referencia. Cada fragmento de mucosa gástrica examinado condujo a un diagnóstico individual para cada biopsia que se comparó con el patrón de referencia. La variabilidad intra-observador se evaluó en 127 personas que corresponden a una muestra aleatoria de 20% del total de endoscopias hechas a los 72 meses de seguimiento. Resultados La sensibilidad del diagnóstico de MI y displasia gástrica aumentó de manera significativa con el número de fragmentos de mucosa gástrica evaluados El sitio anatómico de mayor sensibilidad para el diagnóstico de MI y displasia fue la incisura angularis. Para descubrir H. pylori se logró alta sensibilidad con el estudio de un solo fragmento de mucosa gástrica (95.9%) y fue independiente del sitio de obtención de la biopsia. El acuerdo intra-observador para el diagnóstico de gastritis crónica fue 86.1% con valor kappa de 0.79 IC 95% (0.76-0.85). Las

  20. Contrast-enhanced US of the prostate with time/intensity curves: Preliminary results.

    Science.gov (United States)

    Valentino, M; De Matteis, M; Casadio Baleni, M; Monteduro, F; Paganelli, F; Pavlica, P; Barozzi, L

    2008-03-01

    Sommario SCOPO: Determinare la performance diagnostica dell'ecografia con mezzo di contrasto di seconda generazione nello studio delle lesioni focali della prostata nei pazienti con elevati valori sierologici di antigene prostatico specifico. MATERIALI E METODI: Sei pazienti consecutivi (età 72–87 anni) con elevati valori di antigene prostatico specifico (≥4 ng/ml) sono stati sottoposti a ecografia transrettale tradizionale seguita da ecografia con mezzo di contrasto. In ogni paziente sono state identificate le aree periferiche di alterata ecostruttura sospette per lesione neoplastica. Queste aree sono state valutate con ecografia con mezzo di contrasto mediante curve di intensità/tempo. I dati ottenuti sono stati confrontati con la biopsia dell'area sospetta. RISULTATI: L'ecografia con mezzo di contrasto ha consentito di identificare due pattern distinti: pattern 1 caratterizzato da rapida elevazione della curva calcolata a livello della lesione rispetto all'intensità di impregnazione del parenchima adiacente. Due dei sei pazienti con questo pattern hanno dimostrato presenza di lesione neoplastica nell'area sottoposta a biopsia. Pattern 2 caratterizzato da scarsa elevazione della curva rispetto all'intensità dell'impregnazione del parenchima adiacente. I rimanenti 4 dei 6 pazienti esaminati avevano questo pattern e l'area bioptizzata ha dimostrato assenza di lesione neoplastica. CONCLUSIONI: L'ecografia con mezzo di contrasto di seconda generazione, attraverso le curve di intensità/tempo può identificare differenze di comportamento tra tessuto normale e patologico. Queste caratteristiche possono risultare utili soprattutto nel caso di aree ipoecogene all'ecografia basale per identificare le aree da sottoporre a biopsia.

  1. Nefropatía mesangial IgA

    OpenAIRE

    Darnell Tey, Alejandro

    1988-01-01

    El objetivo de esta Tesis es realizar un estudio retrospectivo de características clínicas histológicas de la nefropatía idiopática en una serie amplia de pacientes, aportar acerca de la historia de enfermedad y conocer qué factores pueden relacionarse con el de la enfermedad.En ella se analiza la historia clínica y la biopsia renal de 100 pacientes, 77 adultos y 23 niños, diagnosticados de nefropatía entre septiembre de 1975 y diciembre de 1986 en el Servicio de Nefrología del Hospital Clíni...

  2. VASCULITIS DE CHURG-STRAUSS: PRESENTACIÓN CLÍNICA COMO GLOMERULONEFRITIS EXTRACAPILAR NECROTIZANTE PAUCI-INMUNE CON NEFRITIS TUBULO-INTERSTICIAL EOSINOFÍLICA.

    OpenAIRE

    Fernanda da Cunha; Edgar Lorga; Tânia Sousa; Jesús Garrido.

    2004-01-01

    RESUMEN: Se presenta el caso clínico de una mujer de 81 años con antecedentes patología pulmonar obstructiva crónica "idiopática" que desarrolló un cuadro de insuficiencia renal aguda aparentemente prerrenal, con posterior oliguria y eosinofilia simulando una nefropatía túbulo-intersticial alérgica. La evolución atípica y la presencia de p-ANCA, sugerían una vasculitis, patología que se confirmó con la biopsia renal. Los resultados anatomopatológicos revelaron la existencia de una glomerulone...

  3. Leucemia Cutis de presentación atípica An atypical presentation of Leukemia Cutis

    Directory of Open Access Journals (Sweden)

    F Pulgar Martín

    2011-06-01

    Full Text Available El trabajo aporta un nuevo caso de leucemia cutis, raro en frecuencia, que presenta un comienzo clínico muy poco habitual, a tener en cuenta. Fueron necesarias varias biopsias para llegar al diagnóstico de la paciente. La supervivencia de la paciente está por encima de la media en estos casos.The work presents a new case of leukemia cutis, rare in frequency, which has a very unusual clinical onset to take into account. It took several biopsies for the diagnosis of the patient. The survival of the patient is above average in these cases.

  4. [Sentinel lymph node metastasis in patients with ductal breast carcinoma in situ].

    Science.gov (United States)

    Ruvalcaba-Limón, Eva; de Jesús Garduño-Raya, María; Bautista-Piña, Verónica; Trejo-Martínez, Claudia; Maffuz-Aziz, Antonio; Rodríguez-Cuevas, Sergio

    2014-01-01

    Antecedentes: en pacientes con carcinoma ductal in situ la biopsia de ganglio centinela es motivo de controversia porque se reportan ganglios positivos en 1.4-12.5% debido al carcinoma invasor oculto en la pieza quirúrgica. Objetivo: conocer la frecuencia de metástasis en ganglio centinela en pacientes con carcinoma ductal in situ e identificar las diferencias entre los casos positivos y negativos. Material y métodos: estudio retrospectivo, transversal, analítico de pacientes con carcinoma ductal in situ a quienes se realizó una biopsia de ganglio centinela por requerir mastectomía, tener un tumor palpable, lesión radiológica = 5 cm, inadecuada relación mama-tumor o porque la escisión pudiera afectar el flujo linfático. Resultados: de 168 carcinomas in situ, se incluyeron 50 casos con carcinoma ductal in situ y biopsia de ganglio centinela, de pacientes con edad promedio de 51.6 años, 30 (60%) de ellas asintomáticas. Los signos reportados fueron: nódulo palpable (18%), secreción por el pezón (12%) o ambos (8%). Predominaron las microcalcificaciones (72%), comedonecrosis (62%) y grado histológico -2 (44%) con 28% de receptores hormonales negativos. En el estudio transoperatorio 4 (8%) pacientes tuvieron ganglio centinela positivo y un caso en estudio histopatológico definitivo (60% micrometástasis, 40% macrometástasis), todos con carcinoma invasor en la pieza quirúrgica. Las pacientes con ganglio centinela transoperatorio positivo eran más jóvenes (44.5 vs 51 años), con más tumores palpables (50 vs 23.1%), más grandes (3.5 vs 2 cm), más comedonecrosis (75 vs 60.8%), más indiferenciados (75% vs 39.1%) y menos receptores hormonales (50 vs 73.9%), que las que tenían ganglio centinela negativo, sin que estas diferencias tuvieran significación estadística. Conclusiones: puesto que 1 de cada 12 pacientes con carcinoma ductal in situ tiene afectación ganglionar en el ganglio centinela, se recomienda seguir tomando la biopsia para evitar

  5. Preservación de espermatozoides de la cola del epidídimo bovino en condiciones de campo

    OpenAIRE

    Durán, J. P.; Espinoza, J. R.; Cabrera, N. C.; Aponte, P. M.; Universidad de Cuenca; Dirección de Investigación de la Universidad de Cuenca; DIUC

    2015-01-01

    La cola del epidídimo constituye un reservorio de espermatozoides que han alcanzado la madurez biológica a través de su trayecto por el largo conducto del epidídimo (Robaire y Hinton, 2014). Los espermatozoides de esta reserva epididimaria pueden obtenerse postmortem o a través de biopsias y utilizarse con fines reproductivos (Albers y Barrios, 2011). El presente trabajo tiene como objetivo principal probar algunas condiciones iniciales de manejo de espermatozoides de la cola del epidídimo de...

  6. RUPTURA UTERINA ESPONTANEA POR PLACENTA PERCRETA

    OpenAIRE

    2003-01-01

    La rotura uterina en un útero sin cicatriz previa, y temprano en el tercer trimestre, es un evento raro. Se expone el caso clínico de una paciente que se presenta con abdomen agudo, cursando embarazo de aproximadamente 25 semanas, se realiza laparotomía exploradora encontrando hemoperitoneo, feto y placenta libres en la cavidad peritoneal y útero roto en el fondo invadido por la placenta, que compromete epiplón mayor. Se realiza histerectomía y se confirma el diagnóstico con biopsia

  7. Identificación de factores biológicos asociados con la afectación del ganglio centinela y/o los ganglios no centinela en el cáncer de mama

    OpenAIRE

    Beridze Vaktangova, Nana

    2014-01-01

    La técnica de la biopsia selectiva del ganglio centinela en el cáncer de mama no está exenta de falsos negativos, con un efecto adverso sobre el tratamiento óptimo de las pacientes. Además, su desarrollo nos plantea nuevos interrogantes, tales como la posibilidad de obviar la práctica de la técnica en aquellos casos de carcinomas de mama en estadio muy precoz o muy baja probabilidad de afectación ganglionar; o como identificar a ese importante porcentaje de mujeres (32-68 %) que presentan afe...

  8. Lepra Dimorfa Lepromatosa (Borderline Lepromatosa, BL) Dimorphous Lepromatous Leprosy (Borderline Lepromatous, BL

    OpenAIRE

    M Palombo; RE Achenbach; GF Sánchez; Dupuy, S.

    2012-01-01

    Presentamos un caso de lepra dimorfa lepromatosa, en un hombre austríaco radicado en la Argentina desde hace 40 años, que presentaba placas infiltradas monomorfas y asintomáticas en tronco y miembros, sin alteraciones neurológicas periféricas evidentes. La biopsia de una de las lesiones demostró áreas de hiperplasia fibroblástica perineural "en catafilas de cebolla", granulomas en contacto focal con la epidermis, con transgresión del muro de contención y abundantes bacilos ácido-alcohol resis...

  9. Valor de los metodos directos e indirectos de diagnóstico en las micosis sitémicas asociadas al SIDA

    OpenAIRE

    Arechavala,A.I.; A.M. Robles; R. Negroni; Bianchi,M.H.; A. Taborda

    1993-01-01

    Durante 5 años se estudiaron 117 pacientes con micosis sistémicas asociadas al SIDA: 74 criptococosis, 39 histoplasmosis y 4 con ambas enfermedades. Para el diagnóstico analizamos los siguientes materiales: escarificaciones de lesiones cutáneas o mucosas, aspirados de médula ósea, secreciones bronquiales, biopsias de diversos órganos, líquido cefalorraquídeo, hemocultivos y sueros para determinaciones serológicas. Fueron estudiadas en total 203 muestras de pacientes con histoplasmosis, el 46....

  10. Características clínicas y sociodemográficas de pacientes colombianos con Síndrome de Sjögren solo y asociado a otras enfermedades autoinmunes

    OpenAIRE

    Amador-Patarroyo, Manuel-José

    2013-01-01

    Introducción: Dado que una de las principales comorbilidades asociadas al síndrome de Sjögren es la presencia de otra enfermedad autoinmune, el objetivo de este estudio fue investigar la frecuencia de poliautoinmunidad en pacientes con síndrome de Sjögren y evaluar sus factores asociados. Métodos: Este fue un estudio de corte transversal en el que 410 pacientes con síndrome de Sjögren (por criterios del Consenso Americano-Europeo, incluyendo biopsia positiva) fueron sistemáticamente inclu...

  11. DIAGNÓSTICO PRENATAL INVASIVO AL FINAL DEL PRIMER TRIMESTRE: RESULTADOS DE UN ENSAYO INTERNACIONAL RANDOMIZADO (1) Philip J, Silver RK, Wilson RD, Thom EA, Zachary JM, Mohide P, Mahoney MJ, Simpson J L, Platt LD, Pergament E, Hershey D, Filkins K, Johnson A, Shulman LP, Bang J, MacGregor S, Smith JR, Shaw D, Wapner RJ, Jackson LG. For the NICHD EATA Trial Group. Obstet Gynecol 2004; 103(6): 1164-73.

    OpenAIRE

    González R,Christian; Vera,Claudio; Carvajal C,Jorge

    2004-01-01

    Objetivo: Determinar, en un ensayo aleatorizado, la seguridad y la exactitud de la amniocentesis y de la biopsia de vellosidades coriales (BVC) realizada entre las 11-14 semanas de gestación, dado que en este periodo es cada vez más relevante a la investigación temprana de las trisomias. Método: Se comparó amniocentesis con BVC a partir de los 77 a 104 días de gestación en un ensayo aleatorizado en una población materna predominantemente de edad avanzada. Antes de la randomización, la factibi...

  12. Cáncer oral: Métodos de diagnóstico (screening rápido en la consulta odontológica

    Directory of Open Access Journals (Sweden)

    J.R. Barbany

    Full Text Available Se analizan los procedimientos existentes en el mercado, destinados al diagnóstico rápido de lesiones de la mucosa oral sospechosas de malignidad, en la consulta odontológica. De entre los distintos métodos propuestos: tinción con colorantes, iluminación con luz fluorescente y biopsia optimizada con toma de muestras ("brush biopsy", monitorizada por computadora y valorada por un equipo específico de anátomo-patólogos, éste último es el que más documentado y con un mayor nivel de garantía y seguridad.

  13. CONIZACIÓN LEEP EN NIE DE ALTO GRADO EN UNA INSTITUCIÓN PRIVADA DE SALUD

    OpenAIRE

    Roa B,Eutimio  ; Osorio F,Eduardo  ; Lizana C,Sergio  ; Herrera Z,Ramiro  

    2009-01-01

    Antecedentes: La conización cervical del cuello uterino es considerada el tratamiento de elección de las neoplasias intraepiteliales de alto grado. Objetivo: Analizar los resultados del tratamiento de esta patología mediante conización Leep. Método: Se revisan los antecedentes y biopsias de 145 pacientes con diagnóstico histológico de neoplasia intraepitelial II y III tratadas con conización cervical por asa Leep en la Unidad de Patología del Tracto Genital Inferior de Clínica Dávila desde el...

  14. RECTAL BIOPSY IN SHEEP AND GOATS FOR MONITORING AND ANTE-MORTEM DIAGNOSIS OF SCRAPIE: NUMBER OF LYMPHOID FOLLICLES IN TWO CONSECUTIVE COLLECTIONS

    Directory of Open Access Journals (Sweden)

    Helen Caroline Raksa

    2016-07-01

    O acúmulo da PrPSc em tecidos linfoides levou ao desenvolvimento de procedimentos de biopsia para o diagnóstico ante mortem da scrapie em ovinos, utilizando tecidos acessíveis como a tonsila(5 e terceira pálpebra(6, e a técnica de imuno-histoquímica (IHQ. Por outro lado, a grande área de folículos linfoides presente no reto de ovinos(7 tornou a biopsia retal uma possibilidade de diagnóstico ante mortem da scrapie. Amostras da mucosa retal têm sido colhidas e analisadas por meio de provas de IHQ para avaliar a presença de PrPSc no tecido linfoide associado à mucosa retoanal (RAMALT, do inglês Recto-Anal Mucosa Associated Lymphoid Tissue(8,9. No Brasil, o primeiro relato de scrapie foi em 1978, em um ovino Hampshire Down, importado da Inglaterra(10. Segundo a OIE, de 2008 a 2014 foram sacrificados 41 animais no país, em surtos de scrapie(11. Desde 2008, o diagnóstico de scrapie é realizado por meio da técnica de IHQ a partir de amostras do SNC e tecidos linfoides(12. Porém, no caso de tecidos linfoides associados à mucosa retal, pode haver necessidade de novas colheitas em curtos intervalos de tempo devido à escassez de tecido para o diagnóstico da doença que, segundo Leal et al.(13, deve ser de no mínimo três folículos linfoides (FL por amostra. Visando ao reconhecimento de boas técnicas para o monitoramento e o diagnóstico ante mortem da scrapie, o presente estudo teve por objetivo avaliar a quantidade de tecido linfoide associado à mucosa retal obtido pela técnica de biopsia retal e com vistas à avaliação imuno-histoquímica, bem como a possibilidade de se realizarem dois procedimentos de biopsia consecutivos, em diferentes intervalos de tempo, em ovinos e caprinos.

  15. Enfermedad de. Lafora y efecto fundador en una pequeña localidad neotropical

    OpenAIRE

    Solís, María Virginia

    2015-01-01

    La enfermedad de Lafora es una condición genética infrecuente. Cuatro casos (dos familias) fueron detectados en ZarceTo, una pequeña localidad de Costa Rica (población bajo'2000). Ellos pertenecieron a dos matrimonios consanguíneos y ambas familias tenían ancestros comunes. El diagnóstico de Enfermedad de Lafora fue confirmado por medio de una biopsia de hígado en uno de los pacientes. Las edades de aparición fueron 13, 14, 16 Y 17 años. Los pacientes murieron después de cuatro, nueve, seis y...

  16. Tumor odontogénico queratoquístico: Hallazgo radiográfico y resolución quirúrgica de un caso clínico Keratocystic odontogenic tumor: Radiographic findings and surgical management of a clinical case

    OpenAIRE

    J. Vázquez Diego; C. Gandini Pablo; Ramírez, María J; José N. Ibero; Eduardo E. Carbajal

    2012-01-01

    Se presenta un caso clínico de queratoquiste odontogénico. El paciente de 26 años de edad es de sexo femenino. Se utilizan las técnicas radiológicas intrabucales y extrabucales para localizar y diagnosticar presuntivamente dicha patología. Posteriormente se realiza la biopsia que corrobora el diagnóstico presuntivo y se realizó intervención quirúrgica en la que se lleva a cabo la enucleación del tumor. Se realizaron los controles periódicos a corto, mediano y largo plazo en el que no se const...

  17. Encefalitis a citomegalovirus en un paciente inmunocompetente: análisis clinico, neuropatologico y ultraestructural

    OpenAIRE

    2001-01-01

    Las encefalitis por citomegalovirus en pacientes inmunocompetentes son excepcionales, siendo un patógeno reconocido en pacientes inmunodeprimidos (SIDA, transplantados). Se reporta el caso clínico de una encefalitis por Citomegalovirus en un adulto joven, sin evidencia de enfermedad inmunosupresora, cuyo diagnóstico fue posible mediante la detección de ADN viral en la biopsia cerebral. Se describen además las singularidades clínicas de este caso y los hallazgos de la anatomía patológica y de ...

  18. Cultivo in vitro con colágeno y fibroblastos humanos de un equivalente de mucosa oral de espesor total In vitro culture with collagen and human fibroblasts of a full-thickness oral mucosa equivalent

    OpenAIRE

    S. González Mendez; L.M. Junquera Gutiérrez; I. Peña González; V. García Díaz; L. Gallego López; García Pérez, E.; A. Meana Infiesta

    2009-01-01

    Objetivos. El presente trabajo tiene por objetivo obtener, mediante cultivo in vitro, láminas de tejido oral en las que se pueda identificar las estructuras de una mucosa oral completa. La aplicación clínica del presente estudio permitiría, en determinados casos, la sustitución del empleo de injertos libres de piel o autólogos de mucosa oral por esta técnica. Material y Método. A partir de pequeñas biopsias de mucosa oral se hicieron cultivos primarios de queratinocitos. A partir de estos cul...

  19. Análisis ultraestructural de la formación ósea en relación con el OsteoGen®

    OpenAIRE

    C. López Valenzuela; E. Javer Manzur; S. Arroyo Palacios; A. Oyarzun Droguett

    2002-01-01

    El OsteoGen®, ha sido profusamente utilizado como material osteoconductor en cirugía periodontal. Sin embargo las características estructurales de la interfase y del hueso neoformado han sido escasamente evaluadas en el ser humano. Con el objeto de estudiar la calidad de la reparación ósea alrededor de OsteoGen®, se injertó el material en defectos óseos de dos pacientes . Las biopsias fueron tomadas a los 6 y 12 meses y procesadas para microscopía optica ( MO ) y electrónica de transmisión ( ...

  20. Rinoescleroma

    OpenAIRE

    John Segura-Vílchez; Paulina González-Rojas; Lissette Retana-Moreira

    2013-01-01

    Paciente masculino de 19 años de edad, proveniente de zona rural, con cuadro clínico de 3 años de oclusión nasal, episodios de inflamación facial, epistaxis, rinorrea fétida, hipoacusia derecha, adenopatías faciales múltiples y axilares bilaterales; fue referido al Hospital México por una lesión granulomatosa obstructiva del tabique nasal. Una biopsia inicial reveló la presencia de tejido con infiltrado inflamatorio crónico, con predominio de macrófagos de aspecto espumoso. Una segunda biopsi...

  1. Rinoescleroma Rhinoscleroma

    OpenAIRE

    John Segura-Vílchez; Paulina González-Rojas; Lissette Retana-Moreira

    2013-01-01

    Paciente masculino de 19 años de edad, proveniente de zona rural, con cuadro clínico de 3 años de oclusión nasal, episodios de inflamación facial, epistaxis, rinorrea fétida, hipoacusia derecha, adenopatías faciales múltiples y axilares bilaterales; fue referido al Hospital México por una lesión granulomatosa obstructiva del tabique nasal. Una biopsia inicial reveló la presencia de tejido con infiltrado inflamatorio crónico, con predominio de macrófagos de aspecto espumoso. Una segunda biopsi...

  2. Características clínicas y anatomo-patológicas de las pacientes que ingresaron al Programa de Control de Tuberculosis con diagnóstico de tuberculosis de mama

    OpenAIRE

    Tafur, Karla; Cáceres, Jaime; ACCINELLI, Roberto

    2014-01-01

    Objetivo: Describir las características clínicas y anatomo-patológicas de pacientes que ingresaron con diagnóstico de TB de mama al Programa de control de Tuberculosis (PCT) de un hospital general. Material y métodos: Se incluyeron los casos registrados en el PCT como TB de mama en cuyo informe anatomo-patológico figuraba inflamación crónica granulomatosa. Se revisaron las historias clínicas y revaluaron las biopsias de mama. Resultados: Se incluyeron 69 mujeres con edad promedio 35,79 ± 7,94...

  3. Nevos sebáceo linear de Jadassohn: registro de um caso

    OpenAIRE

    Aron J. Diament; Patrícia J. Campos-Olazabal; Espinoza Espinoza,Ruth F.

    1982-01-01

    É relatado um caso de nevos sebáceo linear de Jadassohn, com sua forma clínica, apresentando a clássica tríade: 1) nevos facial; 2) crises focais; e 3) retardo mental progressivo, aparentemente. Apresenta-se no primeiro estadio de desenvolvimento, quando as glândulas sebáceas estão pouco desenvolvidas, à biopsia de pele. À TAC apresenta atrofias córtico-subcorticais discretas, contrastando com a intensidade do retardo mental e das crises convulsivas. Estas, foram controladas após várias combi...

  4. Nevos sebáceo linear de Jadassohn: registro de um caso

    Directory of Open Access Journals (Sweden)

    Aron J. Diament

    1982-12-01

    Full Text Available É relatado um caso de nevos sebáceo linear de Jadassohn, com sua forma clínica, apresentando a clássica tríade: 1 nevos facial; 2 crises focais; e 3 retardo mental progressivo, aparentemente. Apresenta-se no primeiro estadio de desenvolvimento, quando as glândulas sebáceas estão pouco desenvolvidas, à biopsia de pele. À TAC apresenta atrofias córtico-subcorticais discretas, contrastando com a intensidade do retardo mental e das crises convulsivas. Estas, foram controladas após várias combinações medicamentosas.

  5. Prevalencia de tumores odontogénicos en el Hospital Base Valdivia: periodo 1989-2008

    OpenAIRE

    L.C. Thiers; C.C. Sotomayor; F.I. Peters; P.C. Lantaño; L.S. Thiers

    2013-01-01

    Objetivo: Este artículo corresponde a un estudio observacional de tipo descriptivo de corte transversal, tiene como objetivo determinar la prevalencia de tumores odontogénicos en la población atendida en el Hospital Base Valdivia, en un periodo de 20 años (1989-2008), según la nueva clasificación de lesiones tumorales de la WHO, 2005. Metodología: Se revisaron 2.078 informes de biopsias correspondientes a lesiones de la cavidad oral de los archivos de informes del servicio de Anatomía Patológ...

  6. Módulo para solicitudes de gammagrafía ósea en pacientes con cáncer

    OpenAIRE

    Morales, Rosanna; Vásquez, Edinson; Cano, Roque; Díaz, Pepe; Vásquez, Mario; Vásquez, María; Rojas, Peter

    2014-01-01

    Se reporta la aplicación de un software que permite registrar con datos completos y pertinentes del paciente, la solicitud para la realización de los exámenes de gammagrafía ósea, con la finalidad que cada información sea consultada adecuadamente y el paciente sea atendido con eficiencia en los servicios de medicina nuclear. La gammagrafía ósea es un estudio de uso frecuente que permite diagnosticar la existencia de un cáncer primario, dirigir un estudio para biopsia o reportar la diseminació...

  7. Metástasis humeral tardía de un cáncer de laringe

    OpenAIRE

    Martínez Martín, Angel Antonio; Vera Alvarez, J.; Sanz Lacalle, Javier; Cuadra Ruiz, J.; Gracia Repollés, Fernando

    1999-01-01

    Presentamos un caso de metástasis ósea única en el húmero cuyo tumor primario fue un cáncer de laringe. Investigamos otras localizaciones primarias pero sólo se encontró esta. La metástasis apareció 6 años después de que el tumor primario fuera detectado. El diagnóstico fue confirmado mediante biopsia. El paciente fue tratado mediante radioterapia local, obteniéndose un alivio de su dolor. We report a case of solitary bone metastasis in the humerus whose primaty tumor was a larynx cancer. ...

  8. Concordancia endoscópico-histológica de la gastritis crónica en Cali

    OpenAIRE

    Gustavo Mariño; Eduardo Lima; Fernado Tuffi García; Carlos Cuello; Harold Cuello; Alberto Alzate

    2009-01-01

    Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad...

  9. Atrofia muscular proximal familiar

    Directory of Open Access Journals (Sweden)

    José Antonio Levy

    1962-09-01

    Full Text Available Os autores relatam dois casos de atrofia muscular proximal familiar, moléstia caracterizada por déficit motor e atrofias musculares de distribuição proximal, secundárias a lesão de neurônios periféricos. Assim, como em outros casos descritos na literatura, foi feito inicialmente o diagnóstico de distrofia muscular progressiva. O diagnóstico correto foi conseguido com auxílio da eletromiografia e da biopsia muscular.

  10. Genomic characterisation of brain malignancies through liquid biopsies: The cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

    OpenAIRE

    Arruda,Letícia de Mattos

    2016-01-01

    Los recientes avances en la secuenciación masiva en paralelo y en las técnicas genómicas digitales apoyan la validez clínica del ADN libre tumoral circulante (ctDNA) como una "biopsia líquida" en el cáncer humano. La presencia de ctDNA en el plasma puede ser útil para identificar alteraciones genómicas, monitorizar la respuesta al tratamiento, identificar la resistencia terapéutica, y potencialmente caracterizar la heterogeneidad del tumor. El estudio de prueba de concepto en el campo de las ...

  11. Complexo distrofina-gllcoproteínas - a propósito de um doente com distrofia de Becker

    OpenAIRE

    Monteiro, Cecília; Taipa, Ricardo; Melo Pires, Manuel; Guimarães, António; Gonçalves, Ana Rita; Vieira, Emília; Santos, Rosário; Santos, Manuela

    2012-01-01

    Introdução: A distrofina faz parte do complexo distrofina-glicoproteínas (DAG - dystrophin associated glicoproteins) que inclui as sarcoglicanos α, β, y e δ, bem com as distroglicanos α e β. O estudo imunohistoquímico da biopsia muscular das distrofinopatias pode assim mostrar alterações na marcação não só da distrofina, como também das outras proteínas associadas. Caso clínico: Apresentamos um doente do sexo masculino com quadro clínico caracterizado por cãibras e dores musculares d...

  12. Diagnóstico de la toxocarosis humana Diagnosis of human toxocarosis

    OpenAIRE

    2010-01-01

    La toxocarosis humana es una importante zoonosis parasitaria causada por formas larvarias de especies del género Toxocara, un parásito nematodo de los perros y los gatos. La migración de la larva por los diferentes tejidos blandos en el ser humano genera una serie de entidades clínicas en el paciente, tales como el síndrome de larva migrans visceral, la toxocarosis ocular y la neurotoxocarosis. El diagnóstico definitivo es mediante la histopatología en biopsias, pero resulta ser casi imposibl...

  13. Criptococosis gingival en un paciente con SIDA

    OpenAIRE

    Delgado-Azañero, Wilson A.; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Meneses Rivadeneyra, Leopoldo; Facultad de Estomatología, Universidad Peruana Cayetano Heredia. Lima,; Gotuzzo Herencia, Eduardo; Instituto de Medicina Tropical “Alexander von Humboldt”. Universidad Peruana Cayetano Heredia. Lima,; Bustamante, Beatriz; Instituto de Medicina Tropical “Alexander von Humboldt”. Universidad Peruana Cayetano Heredia. Lima,

    2014-01-01

    La criptococosis es una infección micótica que afecta a personas con o sin inmunosupresión. Sepresenta principalmente como una infección pulmonar crónica. La mayoría de casos enmucosa oral han sido reportados en pacientes con SIDA que cursaban con la forma diseminadade la infección. Se presenta un paciente varón de 36 años con SIDA, cuyo diagnóstico decriptococosis se estableció por biopsias de las encías. El cuadro oral se caracterizó poragrandamientos gingivales del sector ántero superior e...

  14. Funciones del coordinador/a TIC : estudio de caso en un centro de la capital onubense

    OpenAIRE

    Rodríguez Miranda, Francisco de Paula

    2005-01-01

    En este artículo comenzamos ofreciendo una definición de coordinador/a TIC. Seguidamente analizamos cuáles son sus funciones, extraídas de nuestro estudio de casos desarrollado en un centro público de educación infantil y primaria (centro TIC) en la capital onubense. Para finalizar ofrecemos una biopsia sobre las funciones más relevantes del coordinador/a TIC, teniendo en cuenta las opiniones del equipo docente del colegio y del resto de sus compañeros en la coordinación TIC de...

  15. Sialosis Parotídea Alcohólica: estudio Estructural y Ultraestructural

    OpenAIRE

    Carda Batalla, María del Carmen; Gómez de Ferraris, María Elsa; Arriaga, Adriana; Carranza, Miriam; Peydró Olaya, Amando

    2004-01-01

    Objetivos: El propósito del presente trabajo fue establecer posibles diferencias histopatológicas entre los estadíos iniciales y terminales de la sialosis alcohólica, patología que generalmente involucra hipertrofia parotídea y afecta estructuralmente en diverso grado a las demás glándulas salivales. Diseño del estudio: se analizaron y compararon las modificaciones estructurales y ultraestructurales de glándulas parótidas provenientes de: A) biopsias de alcohólicos crónic...

  16. QUISTES DE MAXILARES Y MANDÍBULA: ALGUNAS CARACTERÍSTICAS CLÍNICAS Y CORRELACIÓN ENTRE EL DIAGNÓSTICO RADIOLÓGICO E HISTOPATOLÓGICO.

    OpenAIRE

    2008-01-01

    Se realizó un estudio retrospectivo en el Departamento de Patología Bucal de la Facultad de Estomatología de Ciudad de la Habana, desde el 2002 hasta el 2006; con el objetivo de identificar algunas características clínicas y la correlación entre el diagnóstico radiológico e histopatológico de los quistes del maxilar y de la mandíbula.A partir de las 1324 biopsias estomatológicas realizadas en el periodo, fueron seleccionas aleatoriamente 662, se procesaron algunas variables de interés y se ca...

  17. Monoartritis gotosa de muñeca asociada a necrosis del semilunar: a propósito de un caso clínico

    OpenAIRE

    Olmedo García, N.; Mackenney Carrasco, Enrique

    1994-01-01

    Se presenta un caso de monoartritis de muñeca asociada a imágenes radiológicas de necrosis avascular del semilunar que, tras biopsia de la sinovial, se diagnostica de artritis gotosa. Esta asociación es rara. La alteración metabólica que se produce en la gota da lugar a una sinovitis, que provoca un aumento de presión intraarticular. Esta hiperpresión en el carpo podría determinar una necrosis isquémica del semilunar, pero con una evolución diferente a la enfermedad de Kienböck...

  18. Diferencias en el perfil enzimático muscular y respuesta metabólica a la lidia en toros de uno a tres años de edad Differences in muscle enzyme profile and metabolic response to fighting in bulls from one to three years old

    OpenAIRE

    2007-01-01

    La respuesta metabólica al ejercicio depende parcialmente del perfil enzimático muscular y ambos factores pueden verse modificados por la edad. Los objetivos de esta investigación son: 1) Analizar las diferencias en las características musculares de toros de lidia de diferente edad y 2) Valorar si el perfil enzimático muscular se modifica con la edad de forma similar a la descrita en otras razas bovinas. Se extrajeron biopsias inmediatamente tras la lidia -de los músculos glúteo medio y semit...

  19. Doenças de equinos na região Sul do Rio Grande do Sul

    Directory of Open Access Journals (Sweden)

    Clairton Marcolongo-Pereira

    2014-03-01

    Full Text Available Foi realizado um estudo retrospectivo dos diagnósticos de causas de morte e de lesões em equinos na região Sul do Rio Grande do Sul entre 1978 e 2012. Foram revisados os protocolos de necropsia e materiais desta espécie encaminhados ao Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas no período. Foram recebidos 514 cadáveres de equinos e 1500 materiais (biopsias, órgãos, suabes, fezes, sangue e raspado de pele, totalizando 2026 materiais de equinos recebidos no período. Dos 2026 casos 467 (23,05% corresponderam a neoplasmas e lesões tumorifores, 168 (8,29% a doenças parasitárias; 135 (6,66% a doenças bacterianas, 31 (1,53% a doenças virais, 86 (4,24% a doenças causadas por fungos e oomicetos, 50 (2,47% a intoxicações e micotoxicoses, nove (0,44% a doenças metabólicas, 60 (2,96% a outras doenças e 75 (3,70% a doenças não transmissíveis do trato digestivo. Trezentos e vinte (15,79% foram classificados como doenças de etiologia indeterminada. Outros diagnósticos representaram 489/2026 (24,14% casos. Em 44/514 (8,56% das necropsias e em 91/961 (9,47% de biopsias e órgãos remetidos ao laboratório o diagnóstico foi inconclusivo, perfazendo um total de 135/1475 (9,15% casos incluídos nesta categoria. Ficou evidenciado neste trabalho a importância das lesões dermatológicas em equinos, sendo que 31,88% (642/2014 dos casos recebidos eram biopsias de lesões observadas na pele dos animais. Os principais tumores encontrados foram o sarcoide equino com 33,18% e o carcinoma de células escamosas com 7,94% das biopsias recebidas. Algumas causas de morte mais importantes diagnosticadas no período foram a leucoencefalomalacia (7,59%, a raiva (3,70%, o tromboembolismo por Strongylus vulgaris (2,33% e a erliquiose monocítica (1,75%.

  20. Achados histopatológicos renais em idosos

    OpenAIRE

    Carmo, Priscylla Aparecida Vieira do; Kirsztajn,Gianna Mastroianni; Carmo,Wander Barros do; de Franco, Marcello Fabiano; Bastos,Marcus Gomes

    2010-01-01

    INTRODUÇÃO: A população idosa mundial tem aumentado de forma expressiva e pesquisas apontam para um aumento da expectativa de vida dos brasileiros em cerca de 10 anos. Assim como outras comorbidades, as doenças glomerulares também são observadas em idosos e, neste contexto, a biopsia renal surge como ferramenta diagnóstica fundamental para auxiliar a tomada de conduta, evitando, muitas vezes, terapias desnecessárias. OBJETIVO: Estabelecer a frequência dos diagnósticos histológicos em idosos s...

  1. The toxicity of a natural polycarbonate as a potential tissue implant in animals. An investigation

    OpenAIRE

    Luna, M. M.; Brusa, Mario C.; Stornelli, María Alejandra; Stornelli, María Cecilia

    2002-01-01

    El policarbonato (PC) es una extrusión de resina, polímero termoplástico duro, transparente en su forma natural, resistente al impacto, posee las propiedades de un biomaterial. Las aplicaciones más comunes del PC incluyen elementos de óptica, catéteres, dispositivos para biopsias e injertos óseos y envases de medicamentos y alimentos. El objetivo es establecer y comprobar la habilidad del PC para desarrollar una respuesta tisular apropiada como posible implante orgánico en un período de 180 d...

  2. Dermatomicose e ceratite micótica causada por Exophiala sp em um cão Dermatomycosis and mycotic keratitis caused by Exophiala sp in a dog

    OpenAIRE

    2008-01-01

    Neste trabalho, descreve-se o diagnóstico e a conduta terapêutica aplicada em caso de dermatomicose e ceratite micótica causada por Exophiala sp em um cão com um ano e seis meses de idade. Os sinais clínicos incluíam alopecia, crostas, despigmentação e ulceração do plano nasal e focinho, e ceratite superficial bilateral no canto lateral dos olhos. Na cultura fúngica foi isolado Exophiala sp e o exame histopatológico da biopsia cutânea revelou dermatite nodular superficial e profunda granuloma...

  3. Arterite temporal com comprometimento das glândulas salivares

    Directory of Open Access Journals (Sweden)

    Lineu C. Werneck

    1972-09-01

    Full Text Available E relatado um caso de arterite temporal em paciente com crises de cefaléia paroxística associadas a síndrome depressiva e, na última crise, a aumento de volume das glândulas salivares. Biopsia de artéria temporal superficial mostrou aspecto típico de arterite, com células gigantes mononucleadas. A cefalalgia e o aumento de volume das glândulas salivares regrediram mediante a administração de corticoesteróides.

  4. Desarrollo de técnicas para determinar mutaciones del gen K- ras de pacientes con cáncer de pulmón

    Directory of Open Access Journals (Sweden)

    Moreno Pablo

    2004-12-01

    Full Text Available Se desarrolló un protocolo de procesamiento y extracción de ADN para cada uno de los tipos de muestras analizadas: Lavados broncoalveolares (BAL, Biopsias y Tejidos incluidos en parafina (TEPs colectadas de pacientes con cáncer de pulmón de célula no pequeña tipo adenocarcinoma o carcinoma escamocelular. La amplificación de los fragmentos del codón 12 de Kras se realizó utilizando la técnica de “PCR enriquecida”. Se obtuvo un porcentaje de amplificación del 84,6% para biopsias, 70% para BAL y 73,2% para TEPs para un total de 70 muestras, distribuidas en 11 biopsias, siete BAL y 52 TEPs. Se detectaron 18 (25.3% mutaciones en las 70 muestras analizadas: cinco biopsias, tres BAL y diez TEPs. De las 18 mutaciones detectadas, 15 fueron encontradas en hombres fumadores con edad promedio de 68 años. Las restantes tres
    mutaciones fueron encontradas en mujeres no fumadoras con edad promedio de 66 años. 77,7% (14 de las 18 muestras con mutaciones corresponden a tumores de tipo adenocarcinoma mientras solo el 37,5% (3 corresponden a tumores de tipo escamocelular. Todas las muestras con mutación corresponden a tumores de estados avanzados del cáncer. Los resultados hallados corresponden a un reporte preliminar del estado de la mutación K-ras codón 12 en
    tumores de cáncer de pulmón, sin embargo los datos no coinciden con los reportes de la literatura mundial, principalmente debido a variaciones poblacionales, sensibilidad del método de detección y cantidad y tipo de muestra analizada. Además, estos datos describen algunas de las
    características propias de la población portadora de la mutación.

  5. Nefropatía lúpica en niños correlación clínico patológica en una institución pediátrica de bogotá-colombia

    OpenAIRE

    Beltrán Avendaño, Giovanny; Mejía Gaviria, Natalia; Martínez Insuasty, Martha; Martínez Riveros, Paola

    2014-01-01

    Antecedentes. El lupus eritematoso sistémicoes una enfermedad autoinmune que ocasionadepósitos de complejos antígeno-anticuerpo inclusoen los tejidos renales.Objetivo. Describir la relación entre las lesionesobservadas en la biopsia renal y las manifestacionesclínicas, el tratamiento y la evoluciónde la enfermedad en un grupo de pacientespediátricos con lupus eritematoso sistémico.Material y métodos. Estudio retrospectivo de11 pacientes atendidos en la Fundación Hospitalde la Misericordia, de...

  6. Lesiones benignas de la mama y riesgo de cáncer de mama

    OpenAIRE

    Torres Ardanuy, Silvia

    2004-01-01

    Consultable des del TDX Títol obtingut de la portada digitalitzada Hipótesis de trabajo Una historia de biopsia con resultado de patología mamaria benigna, presentan un riesgo de cáncer de mama posterior. Page y Dupont encontraron que las lesiones proliferativas con atipias tienen un RR de 4-5 para cáncer de mama, las lesiones proliferativas sin atipias tienen un RR de 1,5-2 y lesiones benignas de tipo no proliferativo no están asociadas con riesgo de cáncer de mama subsecuente. Sin emb...

  7. Colitis eosinofílica y colitis linfocítica: ¿diferentes manifestaciones histológicas de un mismo proceso en pacientes con diarrea crónica?

    OpenAIRE

    Arévalo, Fernando; Aragón, Violeta; Montes, Pedro; Perez Narrea, Teresa; Monge, Eduardo

    2014-01-01

    Objetivos: 1) Determinar la prevalencia de incremento de eosinófilos en mucosa colónica en pacientes con colitis linfocítica (CL). 2) Determinar la coexistencia de colitis eosinofílica (CE) en pacientes con CL. Materiales y métodos: Las biopsias colónicas de pacientes adultos con diarrea crónica diagnosticados como CL en el hospital Daniel A. Carrión durante octubre 2009 a marzo 2012 fueron revisadas de forma independiente por 2 patólogos. Microscópicamente, se investigó y cuantificó la prese...

  8. Statin and fibrate associed myopathy: study of eight patients Miopatia associada a estatina e fibrato: estudo de oito pacientes

    Directory of Open Access Journals (Sweden)

    Alzira A. Siqueira Carvalho

    2004-06-01

    Full Text Available Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates. Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms.As drogas redutoras de colesterol são ocasionalmente associadas a sintomas neuromusculares e alterações morfológicas observadas na biopsia muscular. Relatamos o curso clínico e achado da biopsia muscular em oito pacientes com hiperlipoproteinemia tratados com drogas redutoras de colesterol (estatinas/fibratos. Cinco pacientes tiveram mialgia e em dois havia fraqueza muscular proximal. Todos os pacientes ficaram assintomáticos após retirada da medicação embora a creatinoquinase permanecesse elevada. Analisamos a biopsia muscular em seis casos realizados entre três meses e dois anos após a suspensão da droga. Encontramos variação no calibre das fibras em todos os casos com necrose de fibras em cinco, infiltrado inflamatório em um caso, presença de vacúolos em um e "ragged red fiber" em três deles. Concluímos que, embora os achados da biopsia muscular não fossem específicos, o uso prolongado de estatinas e/ou fibratos pode induzir a uma miopatia crônica até mesmo na ausência de

  9. Ictericia febril colestásica como forma de presentación de linfoma de Hodgkin

    OpenAIRE

    Max Schindler; Nicolás Kreplak; Lucía Acevedo; Héctor Damis; Guillermo Márquez; María del Carmen Ardaiz

    2014-01-01

    La ictericia febril colestásica como forma de presentación de los linfomas de Hodgkin es un cuadro muy infrecuente. Describimos aquí un caso de síndrome febril prolongado asociado a ictericia progresiva, en el que el diagnóstico de la enfermedad se realiza a través de la biopsia hepática, dada la ausencia de afectación ganglionar que caracteriza a esta enfermedad. Destacamos asimismo el cuadro clínico avanzado y el compromiso multisistémico de una enfermedad rápidamente evolutiva.

  10. Ictericia febril colestásica como forma de presentación de linfoma de Hodgkin

    Directory of Open Access Journals (Sweden)

    Max Schindler

    2014-02-01

    Full Text Available La ictericia febril colestásica como forma de presentación de los linfomas de Hodgkin es un cuadro muy infrecuente. Describimos aquí un caso de síndrome febril prolongado asociado a ictericia progresiva, en el que el diagnóstico de la enfermedad se realiza a través de la biopsia hepática, dada la ausencia de afectación ganglionar que caracteriza a esta enfermedad. Destacamos asimismo el cuadro clínico avanzado y el compromiso multisistémico de una enfermedad rápidamente evolutiva.

  11. Mucormicosis yeyunal en paciente con linfoma de Hodgkin Jejunal mucormycosis in a patient with Hodgkin's lymphoma

    OpenAIRE

    B. Madrigal; J. J. Arenal; Torres, A.; M. J. Peñarrubia; A. Vara; Ruiz, M.; Hernández, A.; P. Enríquez

    2008-01-01

    Comunicamos un caso de mucormicosis intestinal en un hombre de 46 años de edad, diagnosticado de enfermedad de Hodgkin clásica, estadio IV-B. Durante la primera fase de la quimioterapia, sufrió una hemorragia digestiva masiva secundaria a una úlcera yeyunal por zigomicosis tipo mucor, diagnosticada por biopsia endoscópica. El paciente fue tratado con antifúngicos y resección quirúrgica del intestino afectado. En la cirugía, se apreció una doble perforación yeyunal cubierta. El estudio anatomo...

  12. Espectrometría de impedancia eléctrica en tejido pulmonar

    OpenAIRE

    Coll Guich, Núria; Bragós Bardia, Ramon; Muñoz Fernández, Ana María; Pajares, Virginia; Torrego Fernández, Alfons; Riu Costa, Pere Joan

    2016-01-01

    Las biopsias de pulmón son necesarias para el estudio de diversas enfermedades pulmonares. Este es un procedimiento agresivo y tiene la dificultad añadida de conocer la ubicación exacta de la toma de muestras. El método de detección de tejido mediante bioimpedancia eléctrica podría suponer un sistema guía más fiable dado que es capaz de identificar regiones con diferentes propiedades histológicas. Se evalúa la efectividad de este sistema obteniendo datos de impedancia en ...

  13. Presencia de Linfocitos T Reguladores en Periodontitis Crónica

    OpenAIRE

    2010-01-01

    La enfermedad periodontal requiere de un hospedero susceptible para su desarrollo y progresión. Dentro de las características del hospedero se encuentra la respuesta T reguladora, que otorga tolerancia frente a antígenos propios, participa durante las enfermedades infecciosas limitando el daño tisular, sin disminuir la respuesta antibacteriana. El presente estudio tiene por objetivo determinar la presencia, reclutamiento y función de Tregs en pacientes con periodontitis crónica. En 10 biopsia...

  14. Presencia de Linfocitos T Reguladores en Periodontitis Crónica Presence of T Regulatory Cells in Chronic Periodontitis

    OpenAIRE

    2010-01-01

    La enfermedad periodontal requiere de un hospedero susceptible para su desarrollo y progresión. Dentro de las características del hospedero se encuentra la respuesta T reguladora, que otorga tolerancia frente a antígenos propios, participa durante las enfermedades infecciosas limitando el daño tisular, sin disminuir la respuesta antibacteriana. El presente estudio tiene por objetivo determinar la presencia, reclutamiento y función de Tregs en pacientes con periodontitis crónica. En 10 biopsia...

  15. Histiocitosis de células de Langerhans

    Directory of Open Access Journals (Sweden)

    J. Rojo Álvaro

    2014-04-01

    Full Text Available Se describe el caso de un varón con diagnóstico de histiocitosis de células de Langerhans. La histiocitosis X es una enfermedad intersticial con una incidencia real y una prevalencia desconocidas que puede sospecharse por datos epidemiológicos y radiológicos. El diagnóstico puede realizarse mediante BAL y/o estudio anatomo-patológico de biopsia. El principal tratamiento consiste en abandonar el hábito tabáquico. La evolución puede ser variable.

  16. Sensores de microondas para la detección de materiales de alta constante dieléctrica

    OpenAIRE

    Mediavilla Salcedo, Paula

    2012-01-01

    El objetivo principal en el presente proyecto es la detección de tumores con tecnologías no intrusivas ni ionizantes que permitan identificar de forma más precisa las áreas a extirpar, reduciendo de esta forma el tejido sano a sacrificar. Esta aproximación tiene como finalidad el minimizar significativamente el número de biopsias intraoperatorias en el caso de tumores renales y vesicales. El proyecto se ha basado en el diseño de dos métodos diferentes para la detección, análisis y...

  17. Espondilodiscitis cervicales

    OpenAIRE

    2001-01-01

    Se revisaron nueve casos de discitis infecciosas de localización cervical de una serie de ochenta pacientes con espondilodiscitis (10%). Se valoraron mediante historia clínica, analítica y radiología simple todos ellos. Además, seis de ellos se valoraron por Resonancia Magnética, tres por gammagrafía ósea, y un caso por punción-biopsia. Los factores predisponentes eran claros en seis de los pacientes, encontrando entre ellos tres sepsis por Stafilococcus aureus, dos intervenciones quirúrgicas...

  18. Survivability and Infectivity of Viscerotropic Leishmania Tropica from Operation Desert Storm Participants in Human Blood Products Maintained Under Blood Bank Conditions

    Science.gov (United States)

    1993-01-01

    AD-A272 136 PN PAGE OfN Mao_.•. few- ol :i. :1datn ’ o 1. A REPORT TYPE ANdO OATE COVERED 4-TITEuANOSUSTTTU Survivability and Infectivity of Viscero...the kinetics and frequency of peripheral appropriate are ones to prevent transfusion-re- blood parasitemia in humans (donors), the type lated...leucocytes. -Itn J (C1n Pathol 75: 435- hepaticas concomitantes estudiadas en biopsia 438. eon aguja de Vim-Silverman. .Aca .%fed Cos- 15. Nuwavri-Salti

  19. Amplificación del gen hsp18 para la detección de Mycobacterium leprae

    Directory of Open Access Journals (Sweden)

    Róger Calderón E

    2006-10-01

    Full Text Available Mediante PCR se amplificó un fragmento de 360 pb del gen hsp18, que codifica al antígeno proteico de 18kDa de M. leprae, a partir de una biopsia de un paciente con diagnóstico baciloscópico, histopatológico y clínico de lepra. Además, se evaluaron tejidos embebidos en parafina (fijados en formol y ADN de otras micobacterias para determinar la especificidad, sensibilidad y confiabilidad del método. El ensayo de PCR amplificó clara y satisfactoriamente ADN de M. leprae procedente de la biopsia del paciente, pero fue incapaz de amplificar usando ADN purificado a partir de tejidos embebidos en parafina. No se observaron productos de amplificación al utilizar ADN genómico de varias micobacterias tales como M. tuberculosis, M. bovis, M. fortuitum, M. gordonae, M. kansasii, M. scrofulaceum, M. avium entre otras, así como de otras bacterias. Este sistema puede considerarse como una alternativa para la identificación de pacientes infectados con M. leprae orientando el esfuerzo para determinar la prevalencia oculta de la enfermedad mediante la identificación de casos asintomáticos con capacidad de transmisión de bacilos.

  20. [Castleman disease].

    Science.gov (United States)

    Belletti, Gerardo A; Savio, Verónica; Minoldo, Daniel; Caminos, Susana; Yorio, Marcelo A

    2004-01-01

    A 66 years female, who was since last year under astenia, arthralgias, pimply lesions in spread plates and tests showing eritrosedimentation over 100 mm, anemi, leucocitosis with neutrofilia, policlonal hypergammaglobulinemia, slight proteinuria and IgE on 900. This patient was sporadically treated with corticoids. When made the medical consult had lost 34lb., was under anorexy, as well as dyspepsia. Hemoglobyn 6.9 gr/dl, leucocytes 20000/mm3, neutrofils at 90%, proteinogram the same as former, with hypoalbuminemia. She was taking prednisona, 16 mg/day. When examined showed depress of conscience, astenia, and dermic lesions already quoted. 4 cm nonpainful right axillary adenopaty adhered to deep planes. Medulogram with increased iron, hyperegenerative. Ganglionar biopsia: linfoid hyperplasic process linked to inmune response. Toracoabdominal tomography with adenomegalia in torax and retroperitoneo. Skin biopsia: neutrofilic vasculitis. The patient suspends the 16 mg of prednisona and fever as well as generalized adenopatias come up. After laying aside other ethiologies, and understanding as Castleman Multicentric disease, it is started to supply prednisona 1 mg/kg of weight with a clinical and biochemical fast and outstanding response. After 7 months it was progressively suspended the esteroids and 60 days later, the process fall back; for that, corticoids are restarted, with a good evolution. The illness of Castleman although it is not very frequent, it should be considered as differential diagnosis in those clinical cases that are accompanied with important general commitment, linphadenopaties and respons to steroid therapy.

  1. Fascitis nodular en la región frontal: a propósito de un caso excepcional y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Fátima Martínez Pérez

    2015-07-01

    Full Text Available La fascitis nodular es una entidad excepcional en el territorio maxilofacial, consiste en una proliferación benigna del tejido fibroblástico, de etiología desconocida y con características clínicas e histopatológicas similares a los sarcomas. La clínica habitual consiste en una masa de consistencia dura, indolora y de rápido crecimiento. Su diagnóstico se realiza mediante una biopsia y un estudio histopatológico. El tratamiento consiste en la exéresis quirúrgica completa de la lesión. El diagnóstico diferencial es esencial dado el alto potencial de confusión diagnóstica con lesiones sarcomatosas debido a la similitud de sus características clínicas e histopatológicas. Se presenta el segundo caso clínico en la literatura de fascitis nodular en la región frontal, un varón de 43 años de edad, sin sufrir traumatismo previo en dicha localización. Se procedió a la biopsia-exéresis de la lesión con el diagnóstico histológico de fascitis nodular. Sin evidencia de recurrencia del tumor y un resultado estético excelente.

  2. Apoptosis de fibroblastos gingivales en periodontitis

    Directory of Open Access Journals (Sweden)

    Roger Mauricio Arce

    2007-09-01

    Full Text Available Introducción: Los fibroblastos gingivales humanos (FGH tienen un papel importante en la enfermedad periodontal, pues alteran su normal funcionamiento en respuesta a estímulos pro-inflamatorios. Se cree que los fibroblastos se pueden eliminar anormalmente por medio de apoptosis en periodontitis. El propósito de este estudio es determinar y cuantificar la apoptosis de FGH en biopsias del periodonto de individuos sanos y con enfermedad periodontal. Métodos: Se realizó un estudio clínico descriptivo de corte transversal en personas con diagnóstico de salud periodontal (S, gingivitis (G y periodontitis crónica (PC. Se tomaron biopsias escisionales y se hicieron tinciones inmunohistoquímicas (hematoxilina-eosina, caspasa-3 y vimentina. Las placas se interpretaron por histopatología y se digitalizaron para cuantificar las células apoptóticas. Todos los datos se analizaron con un software estadístico para encontrar diferencias significativas (p0.5, r²=0.02; mientras que para las células inflamatorias se encontró una relación proporcional significativa (p<0.05, r²=0.2018. Conclusiones: Los resultados permiten concluir que tanto los fibroblastos gingivales como las células inflamatorias presentan apoptosis manifiesta por la expresión de caspasa-3, y ésta se incrementa significativamente en gingivitis y enfermedad periodontal.

  3. Glomus tumor in a patient suffering from Von Recklinghausen disease. A case presentation. Tumor glómico en un paciente con la enfermedad de Von Recklinghausen. Presentación de un caso.

    Directory of Open Access Journals (Sweden)

    Ricardo Souza Bello

    Full Text Available This is a case of a pacient with Von Recklinghausen desease background, she suffers from pain since 2 years evolution in the pulpex of the second finger in the right hand. A physical and radiographic examination is done and a solitary glomal tumor is diagnosed. She goes under surgical treatment with exeresis and biopsia of the lesion. The anatomopathological examination confirmed the glomal tumor diagnosis.

    Se presenta el caso de una paciente con antecedentes de la enfermedad de Von Recklinghausen, que sufre dolor de aproximadamente 2 años de evolución en el pulpejo del segundo dedo mano derecha. Se realiza examen físico y radiográfico y se diagnostica un tumor glómico solitario. Se somete a tratamiento quirúrgico realizándose exéresis y biopsia de la lesión. El examen anatomopatológico confirmó el diagnóstico de tumor glómico.

  4. An Overlap Syndrome involving systemic lupus erythematosus and autoimmune hepatitis in an adolescent girl.

    Science.gov (United States)

    Battagliotti, Cristina; Rispolo Klubek, Daniela; Karakachoff, Mario; Costaguta, Alejandro

    2016-06-01

    La superposición del lupus eritematoso sistémico y la hepatitis autoinmune se describe ocasionalmente. Aunque ambas enfermedades pueden compartir ciertos hallazgos, como poliartralgias, hipergammaglobulinemia y anticuerpo antinúcleo positivo, son consideradas dos diferentes. Se presenta a una paciente de 14 años con lupus eritematoso sistémico, que, luego de dos años, consultó por ictericia. Sin antecedentes de ingesta de drogas, alcohol o exposición a virus hepatotropos. Tenia un aumento de las enzimas hepáticas con anticuerpos antinúcleo, anti-ADN de doble cadena y LKM 1 positivos. La biopsia hepática mostró una hepatitis de interfase con infiltrado linfoplasmocitario. De esta manera, cumplia con los criterios diagnósticos tanto para lupus eritematoso sistémico como para hepatitis autoinmune. Tratada con corticoides y micofenolato mofetil, mejoró su clinica y laboratorio. Conclusión. La hepatitis autoinmune puede ocurrir en el curso del lupus eritematoso sistémico. Un diagnóstico temprano es importante para prevenir el avance de la enfermedad; es obligatoria la realización de la biopsia hepática.

  5. Rinoescleroma

    Directory of Open Access Journals (Sweden)

    John Segura-Vílchez

    2013-03-01

    Full Text Available Paciente masculino de 19 años de edad, proveniente de zona rural, con cuadro clínico de 3 años de oclusión nasal, episodios de inflamación facial, epistaxis, rinorrea fétida, hipoacusia derecha, adenopatías faciales múltiples y axilares bilaterales; fue referido al Hospital México por una lesión granulomatosa obstructiva del tabique nasal. Una biopsia inicial reveló la presencia de tejido con infiltrado inflamatorio crónico, con predominio de macrófagos de aspecto espumoso. Una segunda biopsia fue positiva por Klebsiella pneumoniae subsp. rhinoscleromatis, y por anatomía patológica se describió una hiperplasia pseudoepiteliomatosa y en lámina propia denso infiltrado inflamatorio con base en linfocitos, células plasmáticas, cuerpos de Russell y macrófagos con citoplasma vacuolado, con presencia de microorganismos y detritos. El paciente recibió terapia con ciprofloxacina vía oral por siete meses, con lo cual resolvió desde el punto de vista etiológico.

  6. Concordancia endoscópico-histológica de la gastritis crónica en Cali

    Directory of Open Access Journals (Sweden)

    Gustavo Mariño

    2009-10-01

    Full Text Available Se realizó un estudio prospectivo con el fin de evaluar la concordancia entre signos endoscópicos y diagnóstico histológico en 216 pacientes con gastritis y metaplasia intestinal. Se estableció un registro codificado de los signos sugestivos de gastritis, que se correlacionaron con los diagnósticos histológicos de las biopsias gástricas. Se seleccionaron aquellas asociaciones que tuvieran una correlación mayor que la esperada por azar. Estas fueron: gastritis atrófica y aumento de visibilidad de vasos en antro, Kappa 0.208 (0.041-0.376; gastritis atrófica y aumento de visibilidad de vasos en cuerpo gástrico, Kappa 0.195 (0.002-0.388; gastritis atrófica y superficie en empedrado en antro, Kappa 0.213 (0.044-0.381; inflamación aguda y pliegues engrosados en antro, Kappa 0.094 (0.018-0.16. Hubo una concordancia pobre entre la mayoría de los signos endoscópicos y los diagnósticos histológicos. El diagnóstico definitivo de la gastritis sólo se debe hacer con base en los estudios histológicos de las biopsias.

  7. Variability among pathologists in the histological diagnosis of helicobacter pylori infection: is it a subjective diagnosis? Variabilidad entre patólogos en el diagnóstico histológico de la infección por Helicobacter pylori: ¿un diagnóstico subjetivo?

    Directory of Open Access Journals (Sweden)

    Luis Fernando Arias Restrepo

    2006-01-01

    Full Text Available Histopathologic diagnosis of Helicobacter pylori (Hp infection is not necessarily easy, and reproducibility is not perfect. Our aim was to determine differences in the frequency of Hp infection according to the pathologists interpreting gastric biopsies in Medellín (Colombia. Materials and methods: All gastric biopsy reports of eight pathologists during one year were reviewed. We excluded cases with intestinal metaplasia, atrophy, dysplasia or carcinoma. We registered patient age, positivity or negativity for H. pylori, and pathologist. We determined the percentage with H. pylori infection and the percentage of each pathologist in order to determine differences. Results: 2.023 cases were included. Each pathologist evaluated a mean of 252.9 ± 154.9 cases (range: 102-445. Patients were 43.5 ± 15.1 years-old (range: 12-90. H. pylori was diagnosed in 1.034 cases (51.1%. The range of positivity according to the pathologist was 38.8-71.1%; mean 51.1% ± 8.7% (p < 0,001. Conclusion: Among pathologists, there is a significant variability in the frequency of diagnosis of H. pylori infection. This result suggests the need to achieve greater homogeneity of concepts and criteria for the diagnosis of this infection, and of its severity. El diagnóstico histológico de la infección por Helicobacter pylori (Hp puede ser difícil, principalmente en casos con pocos microorganismos. Nuestro objetivo fue determinar si hay diferencias significativas en la frecuencia del diagnóstico de la infección por Hp entre patólogos que laboran en Medellín. Materiales y métodos: revisamos todos los informes de biopsias gástricas de ocho patólogos durante un año. Excluimos las biopsias con metaplasia, atrofia, displasia o carcinoma. Registramos la edad del paciente, la presencia o ausencia de Hp y el patólogo que estudió la biopsia. Calculamos el porcentaje de casos con la infección y el porcentaje por patólogo. Finalmente, comparamos estos porcentajes para

  8. Pudendal nerve latency time in normal women via intravaginal stimulation

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    Geraldo A. Cavalcanti

    2006-12-01

    Full Text Available INTRODUCTION & OBJECTIVES: Studies of motor conduction for the efferent functional assessment of the pudendal nerve in women with pelvic dysfunctions have been conducted through researching distal motor latency times. The transrectal approach has been the classic approach for this electrophysiological examination. The objective of the present study is to verify the viability of the transvaginal approach in performing the exam, to establish normal values for this method and to analyze the influence of age, stature and parity in the latency value of normal women. MATERIALS AND METHODS: A total of 23 volunteers without genitourinary pathologies participated in this study. In each, pudendal motor latency was investigated through the transvaginal approach, which was chosen due to patient’s higher tolerance levels. RESULTS: The motor response represented by registering the M-wave was obtained in all volunteers on the right side (100% and in 13 volunteers on the left side (56.5%. The mean motor latency obtained in the right and left was respectively: 1.99 ± 0.41 and 1.92 ± 0.48 milliseconds (ms. There was no difference between the sides (p = 0.66. Latency did not correlate with age, stature or obstetric history. The results obtained in the present study were in agreement with those found by other researchers using the transrectal approach. CONCLUSION: The vaginal approach represents an alternative for pudendal nerve distal motor latency time, with similar results to those achieved through the transrectal approach. Normative values obtained herein might serve as a comparative basis for subsequent physiopathological studies.

  9. Evaluation of the resistive index of prostatic blood flow in benign prostatic hyperplasia

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    Osama Abdelwahab

    2012-04-01

    Full Text Available OBJECTIVE: The aim of this work is to study the resistive index (RI of prostatic blood flow by transrectal power Doppler sonography in benign prostatic hyperplasia (BPH to determine its correlation with other parameters of BPH. MATERIALS AND METHODS: Eighty-two male patients aged 52-86 years with lower urinary tract symptoms (LUTS due to BPH were included in the study. Patients with prostate cancer, neurogenic bladder, or with other pathology (e.g. prostatitis, bladder stone were excluded from the study. All patients were evaluated by full history including Internatinoal Prostate Symptoms Score (IPSS, general and local examination (DRE, neurologic examination, uroflowmetry, laboratory investigations including urine analysis, routine laboratory tests and serum prostate specific antigen (PSA. Transrectal ultrasonography was used to calculate the total prostatic volume. Transrectal Power Doppler Ultrasound (PUD was used to identify the capsular and urethral arteries of the prostate and to measures the RI value. RESULTS: The mean prostate volume was 75.1 ± 44.7 g. The mean RI of the right and left capsular arteries were 0.76 ± 0.06 and 0.76 ± 0.07, respectively. The mean RI of the urethral arteries was 0.76 ± 0.08. There was a high significative correlation between the increase of the RI of the right and left capsular and urethral arteries and the degree of obstruction (P value < 0.001, severity of symptoms (P value < 0.001 and also the prostatic volume (P value < 0.001. CONCLUSION: Resistive index of the prostatic blood flow can be applied as an easy and non-invasive tool to evaluate the lower urinary tract obstruction due to BPH.

  10. Biodegradable estradiol microspheres do not affect uterine involution or characteristics of postpartum estrus in mares.

    Science.gov (United States)

    Arrott, C; Macpherson, M; Blanchard, T; Varner, D; Thompson, J; Simpson, B; Bruemmer, J; Vogelsang, S; Fernandez, M; Fleet, T; Burns, P

    1994-08-01

    Quarterhorse mares were used to investigate effects of estradiol-17beta on uterine involution, duration of estrus, interval to ovulation, and fertility achieved by breeding on the first postpartum estrus. On the day of foaling, mares were injected with biodegradable poly (DL-lactide) microspheres containing either 100 mg estradiol-17beta (25 mares) or no drug (27 mares). The treatment period was considered to last for 12 to 15 d. Estrus was determined by teasing mares (n=16) with a stallion. Ovulation was detected by transrectal ultrasonographic examination of ovaries (n=48). On Days 6, 11 and 16 post partum, transrectal ultrasonography was used to measure cross-sectional diameters of the uterine body, uterine horns, and fluid within the uterine lumen (n=28). Uteri were swabbed for bacteriologic culture, and uterine biopsies were obtained from the previously gravid uterine horn on Days 11 and 16 post partum, for assessment of endometritis and morphometric analysis of endometrial histioarchitecture (n=19). Twenty-two mares were bred on foal-heat, and pregnancy was determined by transrectal ultrasonography on 14 to 16 and 30 to 35 d after breeding. With only one exception (diameter of previously gravid uterine horn on Day 11), mean values for all measures of uterine involution did not differ between treatment groups (P > 0.05). No differences were detected between treatment group means for length of estrus or interval to ovulation (P > 0.05). No differences were detected between treatment group liklihoods for recovery of potential bacterial pathogens, presence of endometritis, or presence of intrauterine fluid at 11 or 16 d post partum (P > 0.05). Pregnancy rate of mares treated with estradiol (5 11 ; 45%) was not different from that of control mares (9 11 ; 82%; P > 0.05). Estradiol treatment did not hasten uterine involution, increase duration of estrus, delay ovulation, or increase fertility in these postpartum mares.

  11. A motorized ultrasound system for MRI-ultrasound fusion guided prostatectomy

    Science.gov (United States)

    Seifabadi, Reza; Xu, Sheng; Pinto, Peter; Wood, Bradford J.

    2016-03-01

    Purpose: This study presents MoTRUS, a motorized transrectal ultrasound system, to enable remote navigation of a transrectal ultrasound (TRUS) probe during da Vinci assisted prostatectomy. MoTRUS not only provides a stable platform to the ultrasound probe, but also allows the physician to navigate it remotely while sitting on the da Vinci console. This study also presents phantom feasibility study with the goal being intraoperative MRI-US image fusion capability to bring preoperative MR images to the operating room for the best visualization of the gland, boundaries, nerves, etc. Method: A two degree-of-freedom probe holder is developed to insert and rotate a bi-plane transrectal ultrasound transducer. A custom joystick is made to enable remote navigation of MoTRUS. Safety features have been considered to avoid inadvertent risks (if any) to the patient. Custom design software has been developed to fuse pre-operative MR images to intraoperative ultrasound images acquired by MoTRUS. Results: Remote TRUS probe navigation was evaluated on a patient after taking required consents during prostatectomy using MoTRUS. It took 10 min to setup the system in OR. MoTRUS provided similar capability in addition to remote navigation and stable imaging. No complications were observed. Image fusion was evaluated on a commercial prostate phantom. Electromagnetic tracking was used for the fusion. Conclusions: Motorized navigation of the TRUS probe during prostatectomy is safe and feasible. Remote navigation provides physician with a more precise and easier control of the ultrasound image while removing the burden of manual manipulation of the probe. Image fusion improved visualization of the prostate and boundaries in a phantom study.

  12. The Healing Effect of Hydroalcoholic Extract of Hypericum Perforatum on Acetic Acid-Induced Ulcerative Colitis in Male Rats

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    Nader Tanideh

    2017-02-01

    Full Text Available Background & Objective: Anti-inflammatory effect of Hypericum have long been considered. Ulcerative Colitis (UC is a form of Inflammatory Bowel Disease (IBD. In this study, the effects of Hypericum perforatum on histopathological changes and tissue malondialdehyde (MDA level of colonic tissue in rats with induced UC were evaluated. Materials & Methods: 70 rats were divided into seven equal groups. Colitis was induced by acetic acid.. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V, as positive control, received 1 mL of intra-colonic Asacol; group VI received 1 mL of normal saline as negative control; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level of colon seven days after the treatment. Results: H. perforatum extract in the two forms of trans-rectal and oral administration could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel had a better healing response than the 10% gel. In oral administration, the 600 mg/kg dosage had a better healing response than the 300 mg/kg. Conclusions: Therefor, H. perforatum can be considered as a treatment of choice for UC especially in trans-rectal gel form.

  13. Comparison of Digital Rectal Examination and Serum Prostate Specific Antigen in the Early Detection of Prostate Cancer: Results of a Multicenter Clinical Trial of 6,630 Men.

    Science.gov (United States)

    Catalona, William J; Richie, Jerome P; Ahmann, Frederick R; Hudson, M'Liss A; Scardino, Peter T; Flanigan, Robert C; DeKernion, Jean B; Ratliff, Timothy L; Kavoussi, Louis R; Dalkin, Bruce L; Waters, W Bedford; MacFarlane, Michael T; Southwick, Paula C

    2017-02-01

    To compare the efficacy of digital rectal examination and serum prostate specific antigen (PSA) in the early detection of prostate cancer, we conducted a prospective clinical trial at 6 university centers of 6,630 male volunteers 50 years old or older who underwent PSA determination (Hybritech Tandom-E or Tandem-R assays) and digital rectal examination. Quadrant biopsies were performed if the PSA level was greater than 4 μg./l. or digital rectal examination was suspicious, even if transrectal ultrasonography revealed no areas suspicious for cancer. The results showed that 15% of the men had a PSA level of greater than 4 μg./l., 15% had a suspicious digital rectal examination and 26% had suspicious findings on either or both tests. Of 1,167 biopsies performed cancer was detected in 264. PSA detected significantly more tumors (82%, 216 of 264 cancers) than digital rectal examination (55%, 146 of 264, p = 0.001). The cancer detection rate was 3.2% for digital rectal examination, 4.6% for PSA and 5.8% for the 2 methods combined. Positive predictive value was 32% for PSA and 21% for digital rectal examination. Of 160 patients who underwent radical prostatectomy and pathological staging 114 (71%) had organ confined cancer: PSA detected 85 (75%) and digital rectal examination detected 64 (56%, p = 0.003). Use of the 2 methods in combination increased detection of organ confined disease by 78% (50 of 64 cases) over digital rectal examination alone. If the performance of a biopsy would have required suspicious transrectal ultrasonography findings, nearly 40% of the tumors would have been missed. We conclude that the use of PSA in conjunction with digital rectal examination enhances early prostate cancer detection. Prostatic biopsy should be considered if either the PSA level is greater than 4 μg./l. or digital rectal examination is suspicious for cancer, even in the absence of abnormal transrectal ultrasonography findings.

  14. Laparoscopic rectocele repair using polyglactin mesh.

    Science.gov (United States)

    Lyons, T L; Winer, W K

    1997-05-01

    We assessed the efficacy of laparoscopic treatment of rectocele defect using a polyglactin mesh graft. From May 1, 1995, through September 30, 1995, we prospectively evaluated 20 women (age 38-74 yrs) undergoing pelvic floor reconstruction for symptomatic pelvic floor prolapse, with or without hysterectomy. Morbidity of the procedure was extremely low compared with standard transvaginal and transrectal approaches. Patients were followed at 3-month intervals for 1 year. Sixteen had resolution of symptoms. Laparoscopic application of polyglactin mesh for the repair of the rectocele defect is a viable option, although long-term follow-up is necessary.

  15. Transurethral resection of the ejaculatory duct.

    Science.gov (United States)

    Paick, J S

    2000-05-01

    Complete bilateral ejaculatory duct obstruction has long been recognized as an uncommon, treatable form of male infertility. Partial ejaculatory duct obstruction reflects a disturbance of ejaculation where sperm quality is impaired during transit through the distal vas deferens and ejaculatory ducts. With the advent and increased use of high-resolution transrectal ultrasonography, abnormalities of the distal ejaculatory ducts related to infertility have been well documented. Although there are no pathognomonic findings associated with ejaculatory duct obstruction, several clinical findings are highly suggestive. In an infertile man with oligospermia or azoospermia with low ejaculate volume, normal secondary sexual characteristics, testes and hormonal profile and dilated seminal vesicles, midline cyst, or calcification on transrectal ultrasonography, ejaculatory duct obstruction is suggested. Of course, other causes of infertility may be concomitantly present and need to be searched for and treated as well. In selected cases, transurethral resection has resulted in marked improvement in semen parameters and pregnancies have been achieved. As is the case with all surgical procedures, proper patient selection and surgical experience are necessary to obtain optimal results. However, it appears that the treatments currently available for relief of ejaculatory obstruction are not optimally effective. Only approximately one half of treated patients will have an improvement in semen parameters and only about one quarter of treated patients will contribute to a pregnancy. What remains to be determined is how to manage the additional nearly 50% of patients who do not benefit from transurethral resection of ejaculatory obstruction. Based on my experience, I suggest that transrectal ultrasonography should be the first diagnostic procedure used when infertile men are suspected of having ejaculatory duct obstruction; however, vasography should still be considered for a more

  16. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples

    OpenAIRE

    Francesco Lotti; Giovanni Corona; Linda Vignozzi; Matteo Rossi; Elisa Maseroli; Sarah Cipriani; Mauro Gacci; Gianni Forti; Mario Maggi

    2014-01-01

    No previous study has evaluated systematically the relationship between metabolic syndrome (MetS) and prostate-related symptoms and signs in young infertile men. We studied 171 (36.5 ± 8.3-years-old) males of infertile couples. MetS was defined based on the National Cholesterol Education Program Third Adult Treatment Panel. All men underwent hormonal (including total testosterone (TT) and insulin), seminal (including interleukin-8 (IL-8), seminal plasma IL-8 (sIL-8)), scrotal and transrectal ...

  17. Granulomatous Prostatitis: Report of Two Cases and Review of the Literature

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    Fikret Erdemir

    2014-03-01

    Full Text Available     Granulomatous prostatitis (GnP accounts for 0.8–1% of benign inflammatory conditions of the prostate. It mimics prostate cancer clinically, histologically and biochemically.Non-specific granulomatous prostatitis is the most common type of granulomatous prostatitis. As most GnP is of the non-specific type, therapy is mainly supportive and up to 62% of the patients have spontaneous resolution. The present study reviews the transrectal ultrasonography results and serum prostate specific antigen (PSA levels of 2 patients with biopsy-proven non-specific granulomatous prostatitis.

  18. Prevention and treatment of biopsy-related complications.

    Science.gov (United States)

    Satyanarayana, Ramgopal; Parekh, Dipen

    2014-02-01

    Transrectal biopsy of the prostate is necessary in the diagnosis of prostate cancer (PC). Though generally considered safe, patients encounter minor complications such as bleeding and urinary symptoms, and uncommonly, serious infections that may require antibiotic therapy, visits to the emergency room (ER) or hospital admission, causing morbidity and rarely even mortality. It is concerning that infections are on the rise due to resistant bacteria. Urologists will have to be aware of bacterial susceptibility studies to reduce such complications. This review focuses on prostate biopsy and its complications, and measures to reduce these complications in our practice.

  19. Characterization of ovarian follicular dynamics in dromedary camels (Camelus dromedarius).

    Science.gov (United States)

    Manjunatha, B M; Pratap, N; Al-Bulushi, Samir; Hago, B E

    2012-09-15

    Ovarian follicular dynamics was monitored by transrectal ultrasonography, for a period of 60 to 90 days, and its correlation with plasma estradiol-17β (E2) and progesterone (P4) were studied in seventeen, multiparous, non-lactating, 12 to 20-year-old dromedary camels. The average number of follicles recruited (12.77 ± 0.93) in each wave between animals varied (P dromedary camels and the IWI and follicle numbers recruited per wave are variable between the animals and repeatable within an individual animal.

  20. A Rare Prostatic Diagnosis of an Old Man: A Pure Prostatic Leiomyoma

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    W. M. van Ulden-Bleumink

    2013-01-01

    Full Text Available A pure leiomyoma of the prostate is a rare benign tumor. An 82-year-old man was referred to our urology department with gross hematuria and complete urinary retention. Examination revealed a benign prostatic hyperplasia. Transrectal ultrasound showed a prostate of 125 mL. Serum PSA was 1.9 µg/L. A simple retropubic prostatectomy was performed. Histopathological examination showed a pure leiomyoma of the prostate, without the presence of glandular prostate tissue. The diagnosis, characteristics, and treatment of this tumor are described.

  1. Prostatic sarcoma of the Ewing family in a 33-year-old male – A case report and review of the literature

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    Lukas Esch

    2016-04-01

    Full Text Available Ewing sarcoma is the second most common primary bone tumor seen in children and adolescents, typically presenting between 10 and 20 years of age. Extraosseous sarcomas of the Ewing family in adults are rare. We report a manifestation of this tumor entity in the periprostatic tissue of a 33-year-old male and discuss our treatment approach. Transrectal biopsy is a feasible and simple diagnostic tool for unclear pelvic masses. Multi-modal therapy and central registries are needed to gain knowledge of rare pelvic tumors like Ewing sarcoma.

  2. Características del ciclo estral, desarrollo embrionario y determinación de la tasa de preñez en yeguas criollas colombianas

    OpenAIRE

    Paredes Higuera, María del Pilar

    2013-01-01

    Para contribuir al establecimiento de valores de referencia durante el ciclo estral (CE) y la gestación temprana en yeguas Criollas colombianas (CC), se realizó seguimiento de la dinámica folicular y del diámetro del cuerpo lúteo (CL) durante dos CE consecutivos por medio de ultrasonografía (US) transrectal diariamente. Se emplearon 30 yeguas entre 4 a 14 años de edad, ubicadas en Pereira (Colombia). Además se tomaron muestras de sangre cada 48 horas durante un CE para cuantifi...

  3. Diámetro del cuerpo lúteo y niveles de progesterona sérica, durante el ciclo estral en yeguas criollas colombianas

    OpenAIRE

    Pilar Paredes H.; Claudia Jiménez E.; Aureliano Hernández V

    2013-01-01

    RESUMENObjetivo. Determinar el diámetro del cuerpo lúteo (CL) y los niveles séricos de progesterona (P4) durante el ciclo estral (CE) en yeguas Criollas Colombianas (CC). Materiales y métodos. Se utilizaron 30 yeguas entre 4 a 14 años de edad, ubicadas en Pereira (Colombia). Se realizó ultrasonografía transrectal diariamente, desde la ovulación (día cero), durante dos CE para evaluar el diámetro del CL. Se tomaron muestras de sangre cada 48 horas entre una ovulación y la siguiente para cuanti...

  4. Dissemination of tuberculosis after biopsy of primary tubercular prostate: a case report

    Directory of Open Access Journals (Sweden)

    Onkar Jha

    2015-01-01

    Full Text Available Only 15-20% of extrapulmonary tuberculosis (TB has been attributed to TB of the urogenital system and often Results from haematogenous spread from an active site of infection. Isolated involvement of prostate by TB is relatively less common. The incidence of primary prostatic TB is unknown and in its truest sense is a very rare entity. Here, we report the case of a patient with primary prostatic TB who was misdiagnosed as nonspecific granulomatous inflammation on transrectal ultrasound-guided biopsy of the prostate, who later presented to our centre after 4 months with disseminated TB. The rarity of the case prompted us to report this case.

  5. Billeddiagnostisk stadieinddeling af kolorektal cancer

    DEFF Research Database (Denmark)

    Rafaelsen, Søren R

    2005-01-01

    The main strength of MR is the ability to define the mesorectal facia. There is recent evidence suggesting that MR imaging can accurately predict the tumor-free circumferential resection margin before total mesorectal excision. However, the prediction of T stage is less accurate and more affected...... by the experience of the observer. Transrectal ultrasonography has proven useful for staging of rectal carcinoma. Computed tomography is one of the most useful imaging techniques for the evaluation of metastatic lesions in colorectal cancer. Udgivelsesdato: 2005-Oct-31...

  6. Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art.

    Science.gov (United States)

    Chen, Frank K; de Castro Abreu, Andre Luis; Palmer, Suzanne L

    2016-10-01

    Prostate cancer screening currently consists of serum prostate-specific antigen and digital rectal examination, followed by transrectal ultrasound-guided biopsy for diagnostic confirmation. Although the current paradigm of prostate cancer screening has led to a decrease in advanced disease and cancer-related mortality, these techniques have limitations in terms of sensitivity and specificity, resulting in missed cancers that are clinically significant and the overdetection of clinically insignificant cancers. New imaging techniques and technologies are required to improve the detection of prostate cancer. This article summarizes the use of novel ultrasound techniques and technologies in the detection, biopsy, and treatment of prostate cancer.

  7. Nonspecific Presentation of a Multiloculated Prostatic Abscess After Transurethral Prostatic Biopsy for Elevated Prostate-specific Antigen Level

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    Nilay M. Gandhi

    2014-11-01

    Full Text Available Prostate postbiopsy infectious complications typically present in the form of prostatitis and uncommonly urosepsis. Prostatic abscesses are generally found after multiple bouts of prostatitis and are associated with a clinically septic picture requiring intensive care unit admission and resuscitation. We report the case of a 65-year-old man who presented with prostatic abscess in the setting of nonspecific urinary symptoms after transrectal ultrasonography–guided prostate biopsy. At 4-month follow-up, he is currently free of disease with undetectable prostate-specific antigen level and negative imaging.

  8. PREOVULATORY FOLLICLE DEVELOPMENT IN HIGH YIELDING COWS

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    Radovan Tomášek

    2013-06-01

    Full Text Available The aim of the study was to examine the development of preovulatory follicles in pregnant and non-pregnant high yielding cows. The treatment by supergestran and oestrophan was used to synchronize the estrous cycle. Ovaries were monitored by transrectal ultrasonography. The linear increase of preovulatory follicles was observed in pregnant (P < 0,001 and non-pregnant (P < 0,001 cows during 8 days before ovulation. In conclusion, preovulatory follicles in pregnant and non-pregnant high yielding cows developed similarly.

  9. Metabolic syndrome and prostate abnormalities in male subjects of infertile couples.

    Science.gov (United States)

    Lotti, Francesco; Corona, Giovanni; Vignozzi, Linda; Rossi, Matteo; Maseroli, Elisa; Cipriani, Sarah; Gacci, Mauro; Forti, Gianni; Maggi, Mario

    2014-01-01

    No previous study has evaluated systematically the relationship between metabolic syndrome (MetS) and prostate-related symptoms and signs in young infertile men. We studied 171 (36.5 ± 8.3-years-old) males of infertile couples. MetS was defined based on the National Cholesterol Education Program Third Adult Treatment Panel. All men underwent hormonal (including total testosterone (TT) and insulin), seminal (including interleukin-8 (IL-8), seminal plasma IL-8 (sIL-8)), scrotal and transrectal ultrasound evaluations. Because we have previously assessed correlations between MetS and scrotal parameters in a larger cohort of infertile men, here, we focused on transrectal features. Prostate-related symptoms were assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS). Twenty-two subjects fulfilled MetS criteria. In an age-adjusted logistic ordinal model, insulin levels increased as a function of MetS components (Wald = 29.5, P parameters of seminal vesicle size or function. In conclusion, in males of infertile couples, MetS is positively associated with prostate enlargement, biochemical (sIL8) and ultrasound-derived signs of prostate inflammation but not with prostate-related symptoms, which suggests that MetS is a trigger for a subclinical, early-onset form of benign prostatic hyperplasia.

  10. Field use of ultrasonography to characterize the reproductive tract and early pregnancy in a phocid, the Weddell seal (Leptonychotes weddellii).

    Science.gov (United States)

    Shero, Michelle R; Adams, Gregg P; Burns, Jennifer M

    2015-12-01

    The utility of transrectal ultrasonography was tested in a field setting to characterize the reproductive tract and detect early pregnancy (embryonic vesicles body, ovaries with follicles and corpora lutea) using a 5-10 MHz linear-array probe with a 70 cm-long extension. A single pregnancy was detected in 14 of 17 seals (82.4%) as a circular or guitar-pick shaped nonechogenic (black) vesicle with a clearly visible echogenic border within the lumen of the uterus. The stage of embryonic development (ostensibly the gestational age) varied markedly among individuals, ranging from a vesicle with no embryo proper to a large fetus with an ocular orbit, nose/mouth, limb buds, spinal column, umbilical cord, and prominent vasculature. Two of the pregnant seals were re-examined 3-6 days after the initial examination to obtain longitudinal growth rates. Images of one or both ovaries were obtained in nine and seven of the 19 examinations, respectively. Numerous ovarian follicles (3 to 12 mm diameter) were detected and animals typically had a single well-perfused corpus luteum (determined by Doppler color-flow) ipsilateral to the uterine horn containing the pregnancy. We conclude that real-time transrectal ultrasonography is an effective tool for characterizing reproductive events in phocids including ovarian dynamics, and for elucidating the nature of embryonic diapause.

  11. THE FIRST EXPERIENCE IN USING THE ULTRASOUND AND MAGNETIC RESONANCE IMAGE FUSION TECHNOLOGY IN THE DIAGNOSIS OF PROSTATE CANCER

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    V. V. Kapustin

    2014-07-01

    Full Text Available Objective: to study the feasibility of the image fusion technology to choose a target portion for needle biopsy in prostate cancer (PC. Subjects and methods. Ultrasound (US-magnetic resonance imaging (MRI-guided needle biopsies were made in 12 patients. All the patients underwent intravenous bolus-enhanced MRI, then MRI and US images were fused during transrectal ultrasound studies (TRUS and targets were determined to make a needle biopsy. Results. The image fusion technology allows one to concurrently assess MRI and US images in the primary diagnosis of prostate cancer and after radical prostatectomy (RPE. The MRI and transrectal images are compared with a high degree of accuracy, providing the clear positioning of the portions substantially accumulating the MRI contrast agent during real-time TRUS. Conclusion. The MRI-US image fusion procedure enables the choice of the targets to be biopsied both in the primary diagnosis of PC and in its suspected recurrence in patients after RPE. The increased accumulation of a MRI contrast agent is a major criterion for choosing a target portion.

  12. THE FIRST EXPERIENCE IN USING THE ULTRASOUND AND MAGNETIC RESONANCE IMAGE FUSION TECHNOLOGY IN THE DIAGNOSIS OF PROSTATE CANCER

    Directory of Open Access Journals (Sweden)

    V. V. Kapustin

    2010-01-01

    Full Text Available Objective: to study the feasibility of the image fusion technology to choose a target portion for needle biopsy in prostate cancer (PC. Subjects and methods. Ultrasound (US-magnetic resonance imaging (MRI-guided needle biopsies were made in 12 patients. All the patients underwent intravenous bolus-enhanced MRI, then MRI and US images were fused during transrectal ultrasound studies (TRUS and targets were determined to make a needle biopsy. Results. The image fusion technology allows one to concurrently assess MRI and US images in the primary diagnosis of prostate cancer and after radical prostatectomy (RPE. The MRI and transrectal images are compared with a high degree of accuracy, providing the clear positioning of the portions substantially accumulating the MRI contrast agent during real-time TRUS. Conclusion. The MRI-US image fusion procedure enables the choice of the targets to be biopsied both in the primary diagnosis of PC and in its suspected recurrence in patients after RPE. The increased accumulation of a MRI contrast agent is a major criterion for choosing a target portion.

  13. Modified uterine allotransplantation and immunosuppression procedure in the sheep model.

    Directory of Open Access Journals (Sweden)

    Li Wei

    Full Text Available OBJECTIVE: To develop an orthotopic, allogeneic, uterine transplantation technique and an effective immunosuppressive protocol in the sheep model. METHODS: In this pilot study, 10 sexually mature ewes were subjected to laparotomy and total abdominal hysterectomy with oophorectomy to procure uterus allografts. The cold ischemic time was 60 min. End-to-end vascular anastomosis was performed using continuous, non-interlocking sutures. Complete tissue reperfusion was achieved in all animals within 30 s after the vascular re-anastomosis, without any evidence of arterial or venous thrombosis. The immunosuppressive protocol consisted of tacrolimus, mycophenolate mofetil and methylprednisolone tablets. Graft viability was assessed by transrectal ultrasonography and second-look laparotomy at 2 and 4 weeks, respectively. RESULTS: Viable uterine tissue and vascular patency were observed on transrectal ultrasonography and second-look laparotomy. Histological analysis of the graft tissue (performed in one ewe revealed normal tissue architecture with a very subtle inflammatory reaction but no edema or stasis. CONCLUSION: We have developed a modified procedure that allowed us to successfully perform orthotopic, allogeneic, uterine transplantation in sheep, whose uterine and vascular anatomy (apart from the bicornuate uterus is similar to the human anatomy, making the ovine model excellent for human uterine transplant research.

  14. Analysis of Acoustic Access to the Prostate Through the Abdomen and Perineum for Extracorporeal Ablation

    Science.gov (United States)

    Hall, Timothy L.; Hempel, Christopher R.; Sabb, Brian J.; Roberts, William W.

    2010-03-01

    As part of the development of a noninvasive treatment for BPH using histotripsy, this study aimed to measure acoustic access for extracorporeal ablation of the prostate. Both transabdominal and transperineal approaches were considered. The objective was to measure the size and shape of a transducer aperture that could target the prostate without obstruction. CT images obtained from 17 subjects >56 years of age were used to create 3D reconstructions of the lower abdomen and pelvis. Target locations on the urethra at the base, mid, and apex in the prostate were marked along with a transrectal imaging probe. Evenly space rays spanning were traced from each target location towards the perineum and separately towards the abdomen with the maximum x-ray density encountered along each path recorded. The overall free aperture through the perineum was found to be a triangular shaped region bounded by the lower bones of the pelvis and the transrectal probe varying significantly in size between subjects. The free aperture through the abdomen was wedge shaped limited by the pubis also with great subject to subject variability. Average unblocked fractions of an f/1 transducer to target base, veru, and apex through the perineum were 77.0%, 94.4%, and 99.6%, respectively. Averages targeting through the abdomen were 86.1%, 52.3%, and 11.0%. Acoustic access to the prostate for through the perineum was judged to be feasible.

  15. CARACTERÍSTICAS DO PARTO E INVOLUÇÃO UTERINA EM OVELHAS NATIVAS DO PANTANAL BRASILEIRO

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    Carlos E. Fernandes

    2013-06-01

    Full Text Available The aim of this study was to describe aspects of the parturition and uterine involution in native sheep from Brazilian Pantanal. Fifty-seven pluriparous ewes were used in this study. At parturition, the placenta expulsion (h, weight (g, total diameter of cotyledons, sex and weight of newborn, and single or twin parturition were evaluated. The uterine involution was evaluated by leucocytes profile, desquamation cells (cervix-uterine smears and transrectal ultrasonography at 1, 7, 14, 21 and 28 days post-partum. The weight of the placenta and total of cotyledons were higher (P0.05 between sex and parturition classification. The total of neutrophils in twin parturitions were higher in days 1, 7 and 14 postpartum (78.5±9.5; 58.5±9.6 and 31.9±9.8, respectively. Macrophages were different (P<0.05 at 1 and 14 days postpartum in ewes with twin parturition (12.5±1.6 and 6.7±1.6, respectively. The regression analysis model revealed a quadratic curve estimation (P<0.001 to the diameter, area and uterine volume considering all postpartum period. In conclusion, the parturition characteristics are similar to other breeds. Leukocytary profile and the transrectal ultrasonography exam suggest that the uterine involution in native sheep of Brazilian Pantanal varies among 14 and 21 days postpartum.

  16. Dual-Modality PET/Ultrasound imaging of the Prostate

    Energy Technology Data Exchange (ETDEWEB)

    Huber, Jennifer S.; Moses, William W.; Pouliot, Jean; Hsu, I.C.

    2005-11-11

    Functional imaging with positron emission tomography (PET)will detect malignant tumors in the prostate and/or prostate bed, as well as possibly help determine tumor ''aggressiveness''. However, the relative uptake in a prostate tumor can be so great that few other anatomical landmarks are visible in a PET image. Ultrasound imaging with a transrectal probe provides anatomical detail in the prostate region that can be co-registered with the sensitive functional information from the PET imaging. Imaging the prostate with both PET and transrectal ultrasound (TRUS) will help determine the location of any cancer within the prostate region. This dual-modality imaging should help provide better detection and treatment of prostate cancer. LBNL has built a high performance positron emission tomograph optimized to image the prostate.Compared to a standard whole-body PET camera, our prostate-optimized PET camera has the same sensitivity and resolution, less backgrounds and lower cost. We plan to develop the hardware and software tools needed for a validated dual PET/TRUS prostate imaging system. We also plan to develop dual prostate imaging with PET and external transabdominal ultrasound, in case the TRUS system is too uncomfortable for some patients. We present the design and intended clinical uses for these dual imaging systems.

  17. Presacral abscess as a rare complication of sacral nerve stimulator implantation.

    Science.gov (United States)

    Gumber, A; Ayyar, S; Varia, H; Pettit, S

    2017-03-01

    A 50-year-old man with intractable anal pain attributed to proctalgia fugax underwent insertion of a sacral nerve stimulator via the right S3 vertebral foramen for pain control with good symptomatic relief. Thirteen months later, he presented with signs of sepsis. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a large presacral abscess. MRI demonstrated increased enhancement along the pathway of the stimulator electrode, indicating that the abscess was caused by infection introduced at the time of sacral nerve stimulator placement. The patient was treated with broad spectrum antibiotics, and the sacral nerve stimulator and electrode were removed. Attempts were made to drain the abscess transrectally using minimally invasive techniques but these were unsuccessful and CT guided transperineal drainage was then performed. Despite this, the presacral abscess progressed, developing enlarging gas locules and extending to the pelvic brim to involve the aortic bifurcation, causing hydronephrosis and radiological signs of impending sacral osteomyelitis. MRI showed communication between the rectum and abscess resulting from transrectal drainage. In view of the progressive presacral sepsis, a laparotomy was performed with drainage of the abscess, closure of the upper rectum and formation of a defunctioning end sigmoid colostomy. Following this, the presacral infection resolved. Presacral abscess formation secondary to an infected sacral nerve stimulator electrode has not been reported previously. Our experience suggests that in a similar situation, the optimal management is to perform laparotomy with drainage of the presacral abscess together with simultaneous removal of the sacral nerve stimulator and electrode.

  18. Pregnancy Loss in Dairy Cattle: Relationship of Ultrasound, Blood Pregnancy-Specific Protein B, Progesterone and Production Variables.

    Science.gov (United States)

    Gábor, G; Kastelic, J P; Abonyi-Tóth, Z; Gábor, P; Endrődi, T; Balogh, O G

    2016-08-01

    Objectives were to determine associations between percentage pregnancy loss (PPL) in dairy cattle and: (i) pregnancy diagnosis by ultrasonography; (ii) pregnancy diagnosis by serum pregnancy-specific protein B (PSPB) concentrations, with or without serum progesterone concentrations; and (iii) production and environmental factors. This study included 149 822 pregnancy diagnoses conducted over 13 years in Holstein-Friesian cows in Hungarian dairy herds. The following were determined: PPL in cows diagnosed pregnant by transrectal ultrasonography 29-42 days after artificial insemination (AI; n = 11 457); PPL in cows diagnosed pregnant by serum PSPB 29-35 days after AI (n = 138 365); and PPL and its association with serum progesterone concentrations, PSPB and production/environmental variables. The definition of PPL was percentage of cows initially diagnosed pregnant based on ultrasonography or PSPB, but not pregnant when examined by transrectal palpation 60 -70 days after AI. The PPL was lower (p 1.1 ng/ml) was lowest (15.0%), whereas cows with low concentrations of both PSPB and progesterone (0.6-1.1 and advanced parity and with high milk production, when ambient temperatures were high, although body condition score (BCS) had no effect on PPL. Finally, there were no significant associations between serum PSPB and environmental temperatures or number of post-partum uterine treatments.

  19. Denonvilliers' space expansion by transperineal injection of hydrogel: implications for focal therapy of prostate cancer.

    Science.gov (United States)

    de Castro Abreu, Andre Luis; Ma, Yanling; Shoji, Sunao; Marien, Arnaud; Leslie, Scott; Gill, Inderbir; Ukimura, Osamu

    2014-04-01

    We developed and assessed a technique of: (i) expanding Denonvilliers' space by hydrogel (polyethylene glycol) during focal cryoabation; and (ii) temperature mapping to ensure protection of the rectal wall. In a fresh cadaver, 20 cc of hydrogel was injected transperineally into Denonvilliers' space under transrectal ultrasound guidance. Successful expansion of Denonvilliers' space was achieved with a range of 9-11 mm thickness covering the entire posterior prostate surface. Two freeze-thaw cycles were used to expand the iceball reaching the rectal wall as an end-point. Intraoperative transrectal ultrasound monitoring and temperature mapping in Denonvilliers' space by multiple thermocouples documented real-time iceball expansion up to 10 mm beyond the prostate, and safety in protecting the rectal wall from thermal injury. The lowest temperatures of the thermocouples with a distance of 0 mm, 5 mm and 10 mm from the prostate were: -35°C, -18°C and 0°C (P focal therapy of prostate cancer.

  20. Ultrasound-guided endocavitary drainage of pelvic abscesses: Technique, results and complications

    Energy Technology Data Exchange (ETDEWEB)

    Ryan, R.S.; McGrath, F P.; Haslam, P.J.; Varghese, J.C.; Lee, M.J

    2003-01-01

    AIM: To evaluate the experience in our institution with ultrasound-guided transrectal and transvaginal (endocavitary) drainage of pelvic abscesses. MATERIALS AND METHODS: Eighteen patients (four male, 14 female; mean age 55 years, range 30-78 years) presenting with pelvic abscesses were referred to our institution for therapeutic drainage over a 4 year period. Patients received broad-spectrum antibiotics prior to drainage, which was performed by either the transvaginal or transrectal route under ultrasound guidance. Patients were given sedo-analgesia in the form of midazolam and fentanyl and local anaesthesia was also employed. Eight French catheters were inserted into the abscess cavities, and patients were subsequently monitored on a daily basis by a member of the interventional radiology team until such time as it was deemed appropriate to remove the catheter. RESULTS: Eighteen catheters were placed in 17 patients, and transvaginal aspiration alone was performed in one patient. Drainage was successful in 16 of 17 patients, but a transgluteal approach was ultimately required in the remaining patient to enable passage of a larger catheter into an infected haematoma. The mean duration of drainage was 5 days, mean time to defervesce 2 days. Spontaneous catheter dislodgement occurred in four patients associated with straining, but this did not have any adverse effect in three of the four patients. CONCLUSION: Endocavitary drainage is an effective method of treatment for pelvic abscesses. Spontaneous catheter dislodgement does not affect patient outcome.

  1. Usefulness and limitations of CT examinations for deep anal fistulas

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Shinichiro; Matsumoto, Akihiko (Yokohama City Univ. (Japan). Faculty of Medicine); Kono, Kazuo (and others)

    1990-05-01

    Preoperative CT examination was performed on 30 cases of deep anal fistula and one case with an anal fistular carcinoma, and its usefulness and the limit of applicability were investigated. The deep anal fistula was recognized as a funicular or tumorous shadow on CT image. The differentiation of tumorous shadow and carcinoma was performed by biopsy under CT observation. While, there were also unidentifiable cases including three out of eight cases (37.5%) in II HC type and one out of 11 cases (9.1%) in II HC and III B types. Particularly, patients with a rectostenosis as the madn lesion could not be identified on CT images. The benefits of CT examination in deep anal fistula were compared with transrectal ultrasonography to establish a procedure for image diagnosis. Transrectal ultrasonography is performed as a routine test and CT examination is added when a lesion waving diameter of more than one cm is observed. Furthermore, active biopsy for patients with suspected carcinoma is planned under CT observation. (author).

  2. Ciprofloxacin-Ceftriaxone Combination Prophylaxis for Prostate Biopsy; Infective Complications

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    Alper Ozorak

    2014-03-01

    Full Text Available Aim: To present our clinical experience about infective complications due to ultrasound guided transrectal prostate biopsy under ciprofloxacin plus third-generation cephalosporin (Ceftriaxone combination prophylaxis. Material and Method: The 1193 patients that used combination of ceftriaxone 1 g intramuscular 1 hour before biopsy and ciprofloxacin 500 mg twice a day for 5 days after biopsy were included to study. Before biopsy, urine analysis and urinary cultures were not performed routinely. Serious infective complications such as acute prostatitis and urosepsis, causing microorganisms were evaluated. Results: Serious infective complications occurred in (1.3% 16 patients. Fifteen of them had acute prostatitis and urine culture results were positive in 10/15 patients for Escherichia coli. The strains were uniformly resistant to ciprofloxacin. Only 1 patient had urosepsis and his blood and urine cultures demonstrated extended- spectrum %u03B2-lactamase-producing (ESBL Escherichia coli also resistant to ciprofloxacin. Antibiotic treatment-related side effects were not observed in any patient. Discussion: Although there is not a certain procedure, ciprofloxacin is the most common used antibiotic for transrectal prostate biopsy prophylaxis. On the other hand, the incidence of ciprofloxacin resistant Escherichia coli strain is increasing. Thus, new prophylaxis strategies have to be discussed. Ceftriaxone plus ciprofloxacin prophylaxis is safe and can be useable option for prophylaxis of prostate biopsy.

  3. Reducing infection rates after prostate biopsy.

    Science.gov (United States)

    Wagenlehner, Florian M E; Pilatz, Adrian; Waliszewski, Przemyslaw; Weidner, Wolfgang; Johansen, Truls E Bjerklund

    2014-02-01

    Over the years, prostate biopsy has become the gold-standard technique for diagnosing prostate carcinoma. Worldwide, several million prostate biopsies are performed every year, most commonly using the transrectal approach. Preoperative antibiotic prophylaxis with fluoroquinolones has been shown to be effective for reducing infection rates. However, in recent years, an increase in febrile infection rates after transrectal prostate biopsy (from 1% to 4%) has been reported in retrospective and prospective studies. The predominant risk factor for infection seems to be the presence of fluoroquinolone-resistant bacteria in faeces. Patients at risk of fluoroquinolone resistance should receive carefully selected antibiotics at sufficient concentrations to be effective. Targeted prophylaxis after rectal flora swabbing has been shown to be efficacious compared with empirical antibiotic prophylaxis. Several forms of bowel preparations are under investigation, although none have yet been shown to significantly reduce infection rates. Perineal prostate biopsy is currently being evaluated as a strategy for preventing the inoculation of rectal flora, but limited data support this approach at present.

  4. Identificación del genotipo del virus del papiloma humano en pacientes portadoras de lesiones cérvico uterinas

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    Alexander Morales Fontaine

    2016-02-01

    Full Text Available Fundamento: en los últimos años se ha observado un elevado predominio de mujeres infestadas por genotipos del  Virus del Papiloma Humano considerados de alto riesgo por su elevada oncogenicidad.Objetivo: identificar los genotipos del Virus del Papiloma Humano en pacientes portadoras de este con lesiones cervicales, cuyas biopsias fueron analizadas en el departamento de anatomía patológica, perteneciente al Hospital General Docente ¨Ernesto Guevara de la Serna¨, en el período comprendido entre enero de 2013 a diciembre de 2014.Métodos: se realizó un estudio descriptivo, de corte transversal, en 45 pacientes cuyas biopsias fueron tomadas de forma aleatoria de un total de 456 casos en los que se encontraron evidencias histopatológicas de infección por el  Virus del Papiloma Humano, en el período referido período de estudio. Las biopsias fueron enviadas al Laboratorio de Biología Molecular del departamento de Virología del Instituto de Medicina Tropical ´´Pedro Kourí´, a fin de aislar e identificar los tipos de este virus, involucrados en la patogénesis de las lesiones premalignas en estudio. Se utilizaron fuentes secundarias dadas por los resultados de la identificación del genotipo del virus aislado enviados desde dicha institución. Los datos se procearon según la estadística descriptiva, mediante el análisis porcentual.Resultados: en el 88,8 % de la muestra se obtuvo infestación por el Virus del Papiloma Humano, de alto riesgo de oncogenicidad, de ellos hay una preponderancia del genotipo 16, con 26 casos (57,7 % seguido del 31 con 12 aislamientos (26,6 % y 2 pacientes presentaron el genotipo 52 para el 4,4 %. El 6,6 % de la muestra resultó estar infestadas por el genotipo 11, el cual es considerado de bajo riesgo y en 2 casos no fue posible realizar la tipificación.Conclusiones: Existió gran predominio de pacientes afectadas por Virus de Papiloma Humano de alto riesgo de oncogenicidad.

  5. Caracterización de lesiones cervicouterinas en pacientes atendidas en el hospital “Ernesto Guevara de la Serna”

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    Alicia María Yabor Palomo

    2015-11-01

    Full Text Available Fundamento: en los últimos años ha existido un incremento en la incidencia de cáncer cérvicouterino en pacientes pertenecientes a la provincia de Las Tunas.Objetivo: caracterizar a las pacientes con lesiones cervicales, cuyas biopsias fueron analizadas en el departamento de anatomía patológica, perteneciente al Hospital General Docente “Dr. Ernesto Guevara de la Serna”, en el período comprendido entre enero de 2013 y diciembre de 2014.Métodos: se realizó un estudio descriptivo, de corte transversal, en 1369 pacientes con lesiones cervicales, atendidas en el lugar y período de tiempo antes señalado, se utilizó el modelo oficial de biopsia como fuente secundaria de recolección de la información. Los datos fueron procesados utilizando la estadística descriptiva.Resultados: del total de la muestra, la frecuencia de positividad de las biopsias para lesiones cervicales pertenecieron: al año 2013 el 44,4 % y 55,6 % al 2014. Predominaron las mujeres en edad comprendida entre 26 y 35 años, 47,4 %, seguido del grupo de 36 a 55 años, 43,46 %; la neoplasia intraepitelial grado I estuvo presente en el 42,73 %. El 33,6 % de la muestra presentó infección por el virus del papiloma humano, de ellas el 35,28 % correspondieron al 2013 y el 32,19 % al 2014. La neoplasia intraepitelial cervical grado III reportó la mayor cantidad de pacientes con cervicitis, para un 42,95 %, seguido por el carcinoma in situ, presente en el 93 % de la muestra.Conclusiones: se caracterizaron las lesiones cervicouterinas en pacientes de la provincia, predominó el grupo de edad comprendido entre 26 y 35 años, la neoplasia intraepitelial grado I, aproximadamente un tercio estaban infectadas con el virus del papiloma humano, y en las pacientes con neoplasia intraepitelial cervical grado III existió mayor incidencia de cervicitis.

  6. [Pineal region tumors in children: is gross-total resection necessary? A single-center experience].

    Science.gov (United States)

    López-Aguilar, Enrique; Garza-González, María del Carmen; Ortiz-Azpilcueta, Mariana; Sepúlveda-Vildósola, Ana Carolina; Rioscovian-Soto, Ana; de la Cruz-Yañez, Hermilo; Betanzos-Cabrera, Yadira

    2015-01-01

    Introducción: la supervivencia de los niños con tumores de la región pineal se ha incrementado en la última década; estos tienen una evolución insidiosa asociada con los desórdenes endocrinológicos y una alta morbilidad y mortalidad, sobre todo después de la resección. El objetivo es reportar la supervivencia, la morbilidad y mortalidad según el tipo de cirugía, la histología y el tratamiento en un grupo de niños con tumores de la región pineal. Métodos: estudio retrospectivo que incluyó a todos los pacientes con diagnóstico de tumor de la región pineal menores de 17 años de edad que acudieron en un periodo de 10 años a un hospital de pediatría. Se realizó una revisión histopatológica, se determinó la extensión de la resección y se estimó la supervivencia. Resultados: se incluyeron 46 pacientes, 36 de los cuales tenían expediente completo y material de patología adecuado. La resección total se realizó en 24 (66.6 %) y biopsia en 12 (33.3 %); fallecieron 23 pacientes (88 %) y fue el desequilibrio hidroelectrolítico la causa de 14 defunciones (60 %) y la progresión tumoral la causa de las 9 defunciones restantes (39.1 %). La sobrevida a 10 años de los pacientes tratados con resección total y biopsia fue del 52 y 75 %, respectivamente, con una p = 0.7; se presentaron alteraciones endocrinológicas en 13 (36.1%) pacientes de los cuales a 10 (76.9 %) se les realizó la resección de la tumoración. Conclusión: los tumores de la región pineal en niños se pueden tratar con biopsia diagnóstica seguida de tratamiento adyuvante con quimioterapia y radioterapia.

  7. Validación del Protocolo para el Estudio de la Hemorragia Uterina Anormal con Ecografía endovaginal y medio de Contraste (Sonohisterografía.

    Directory of Open Access Journals (Sweden)

    Ricardo Rueda Saenz

    2003-08-01

    Full Text Available

    La evaluación del sangrado uterino anormal (SUA especialmente en los años postreproductivos, convencionalmente se hace recurriendo a las biopsias y aspiraciones endometriales ciegas en el consultorio, o al curetaje uterino bajo anestesia general. Dichos procedimientos, además de ser invasivos, han mostrado ser poco sensibles y específicos en la detección y el tratamiento de la patología focal del endometrio (pólipos, leiomiomas submucosos, y además pueden resultar costosos. Con el advenimiento de la histeroscopia, se han obviado muchas de las dificultades atribuidas a la biopsia ciega y el curetaje uterino, pero aquella, además de requerir un entrenamiento específico y un equipo costoso, requiere de anestesia local o general, en ocasiones dilatación del cervix y en muchas instancias arroja resultados negativos.

    De otro lado, la histeroscopia sólo permite evaluar el canal cervical y la cavidad endometrial, sin poder visualizar la pared miometrial, los anexos y otras estructuras pélvicas, lo cual desvirtúa su uso en una gran proporción de pacientes como investigación inicial rutinaria en el sangrado uterino anormal.

    La utilización de la ecografía transvaginal con contraste líquido (sonohisterografía o histerosonografía permite, por el contrario, no solamente una evaluación precisa y detallada del canal cervical y la cavidad endometrial, sino que permite evaluar la pared miometrial, los ovarios y otras estructuras pélvicas, así como la permeabilidad de las trompas uterinas.

    Este procedimiento tiene además un bajo costo, no requiere de entrenamiento especial, tampoco de anestesia ni de dilatación cervical y tiene bajas tasas de complicaciones. Con la sonohisterografía se pueden seleccionar en forma eficiente y rápida, las mujeres que realmente se benefician de una histeroscopia diagnóstica-operatoria o de una biopsia endometrial ciega de consultorio para evaluar el SUA.

    El presente estudio

  8. Correlación clínico-citohistológica de los quistes congénitos cervicales Clinical-cytohistological correlation of cervicofacial congenital cysts

    Directory of Open Access Journals (Sweden)

    L.D. Medina Vega

    2004-02-01

    Full Text Available Objetivo: Determinar la efectividad de los diagnósticos clínico y citológico en los quistes congénitos cervicofaciales. Método: Se realizó un estudio retrospectivo de los pacientes con diagnóstico clínico, citológico y/o histológico de quiste tirogloso, branquial y dermoide, atendidos en el Hospital Universitario «Arnaldo Milián Castro», durante cinco años. Se calculó la sensibilidad, especificidad y seguridad del diagnóstico clínico y la biopsia por aspiración con aguja fina (FNAC para cada quiste. Resultado: La seguridad del diagnóstico clínico fue de 94,1%, 92,2% y 98% para los quistes tirogloso branquial y dermoide respectivamente. Encontramos mayor tendencia al error clínico en los quistes branquiales, donde las confusiones más frecuentes se presentan con linfoadenopatías inflamatorias. La seguridad de la biopsia por aspiración con aguja fina fue de 96,1% y 94,1% para los quistes tirogloso y branquial respectivamente. Conclusiones: El diagnóstico clínico no es suficiente en ocasiones, por lo que es preciso recurrir a medios diagnósticos complementarios, como la biopsia por aspiración con aguja fina; sin embargo esta prueba no es 100% segura.Objective: To determine the effectiveness of clinical and cytological diagnosis in congenital cysts located in head and neck. Method: We were carried out a retrospective study of patients with clinical, cytological or histological diagnosis of thyroglossal, branchial and dermoid cyst, assisted in the University Hospital Arnaldo Milián Castro", during five years. It was calculated the sensibility, specificity and security of the clinical diagnosis and the Fine Needle Aspiration Biopsy for each cyst. Result: The security of the clinical diagnosis it was respectively of 94,1%, 92,2% and 98% for the thyroglossal, branchial and dermoid cysts. We find bigger tendency to the clinical error in branchial cysts, where the most frequent confusions are presented with inflammatory

  9. Tamoxifeno y afecciones endometriales en pacientes con cáncer de mama

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    Delia B. Dalbert

    2013-04-01

    Full Text Available Los objetivos fueron evaluar la prevalencia de afecciones endometriales en pacientes tratadas con tamoxifeno (TAM y analizar los aspectos epidemiológicos, ecográficos, histeroscópicos e histopatológicos. Desde enero de 1999 a diciembre 2008 se estudiaron 152 pacientes con cáncer de mama tratadas con TAM (20 mg/día, sintomáticas (con sangrado o asintomáticas, pre y postmenopáusicas, incluidas en forma consecutiva. El diseño fue prospectivo y observacional. Los métodos diagnósticos usados fueron ecografía transvaginal, histeroscopía y biopsia. Las pacientes fueron seguidas durante 5 años con ecografía cada 12 meses e histeroscopia con biopsia en casos que lo justificaran. Edad: 62.76 ± 10.24 años y tiempo de tratamiento: 36.2 ± 19.9 meses. El adenocarcinoma se observó en 3/87 (3.45% pacientes con factores de riesgo y en 1/65 (1.54% sin ellos (RA: 1.91, IC 95% 1.88 a 1.94. Las afecciones benignas se hallaron en 148 pacientes (97.37% y los adenocarcinomas en 4 (2.63%,1 en un pólipo de aspecto benigno. Los 4 se observaron en mujeres postmenopáusicas (2 asintomáticas con grosor endometrial igual o mayor a 16 mm. El riesgo de cáncer fue significativamente mayor en sintomáticas (2.36 versus 0.42 en asintomáticas. Tres adenocarcinomas se detectaron entre 24 y 48 meses del tratamiento. Recomendamos un seguimiento con ecografía transvaginal de las pacientes asintomáticas, resección de los pólipos evaluando factores de riesgo y tiempo de exposición, en especial luego de los 24 meses. Consideramos aceptable un cut-off = 10 mm en el grosor del endometrio en postmenopáusicas asintomáticas para realizar histeroscopía y biopsia.

  10. Características clínicas e histopatológicas del síndrome nefrótico primario.

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    Laercio Bolaños

    2009-11-01

    Full Text Available Introducción: La presentación del síndrome nefrótico con proteinuria masiva, hipoalbuminemia, presencia de anasarca y el manejo con altas dosis de esteroides obliga al clínico a reconocerlo oportunamente, manejarlo interdisciplinariamente y tener la habilidad para predecir el curso y pronóstico de la enfermedad después del manejo inicial. Objetivos: Conocer el comportamiento del síndrome nefrótico primario en niños de Cali y área de influencia, sus características demográficas, la presentación clínica, respuesta a tratamiento y clasificación histopatológica y recomendaciones sobre indicación de biopsia renal. Material y métodos: Se revisaron las historias clínicas de 264 niños con síndrome nefrótico entre enero 1986 y julio 2002 con edades entre 1 y 15 años. Resultados: El promedio de edad al diagnóstico fue 4 años y 60% de los pacientes eran del sexo masculino. Todos presentaron edema y proteinuria, 97% hipoalbuminemia, 94% hipercolesterolemia y 54% oliguria; 89% fueron corticosensibles y sólo 11% corticorresistentes. En 65 pacientes con recaídas frecuentes que recibieron citotóxicos se logró remisión de la enfermedad en 40%. Se realizó biopsia renal en 73 (28%; en 29% la indicación fue por resistencia a esteroides y en 71% por recaídas frecuentes o corticodependencia. Los hallazgos histopatológicos mostraron cambios glomerulares mínimos en 36%, proliferación mesangial en 46%, esclerosis focal y segmentaria en 11% y otras enfermedades 7%. Conclusiones: El porcentaje de casos resistentes a esteroides y la presencia de esclerosis segmentaria y focal son más bajos que los descritos en otras series. En niños con racaídas frecuentes o corticodependientes se recomienda intentar un ciclo con citotóxicos antes de programar biopsia renal, esta se debe reservar para los casos corticorresistentes. Sólo 40% del total son controlados en forma regular por el Servicio de Nefropediatría siendo necesario mejorar el

  11. Hemangioendotelioma Epitelioide Pulmonar: reporte de un caso

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    Victoria Monterroso-Azofeifa

    2001-06-01

    Full Text Available En 1983 se reportaron 20 enfermos con un tumor pulmonar raro que fue entonces llamado IVBAT, por sus siglas en inglés (tumor intravascular bronquio-alveolar. Los pacientes se presentaron con numerosos nódulos pulmonares, de crecimiento lento, cuyos hallazgos histológicos variaban desde una apariencia benigna granulomatosa hasta una claramente maligna sarcomatosa. Eventualmente se demostró que el tumor era de origen vascular y se le llamó hemangioendotelioma epiteliode (HEE. Poco después se describió en otras regiones anatómicas. Reportamos aquí el primer caso costarricense de esta estirpe histológica y de presentación pulmonar. Un hombre de 42 años de edad, nos fue referido en fase final con metástasis generalizadas, aunque en buenas condiciones generales. Se le practicó una biopsia pulmonar para definir la histología, pero falleció poco tiempo después sin responder a la terapia instituida. Dieciséis años antes se le habían descubierto nódulos pulmonares pequeños bilaterales y mediante una biopsia abierta se le hizo el diagnostico de HEE. Como el curso de su enfermedad fue considerado estable durante ese tiempo había sido seguido clínicamente. Se comparó el material de la biopsia inicial con el de la reciente, encontrándose mucho mayor celularidad y atipia en la última. Se efectuaron análisis inmunohistoquímicos con un panel de anticuerpos, que permitió establecer la naturaleza vascular del tumor. El HEE es un tumor muy raro, de crecimiento lento y de bajo potencial metastásico, a pesar de ser de origen vascular. Llama la atención el fenómeno de dependencia hormonal de este tumor, que se plantea en la literatura, y que sugiere otras avenidas terapéuticas.

  12. Cambios histométricos del epitelio de la mucosa palatina en pacientes portadores de prótesis completa

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    Watanabe, Romel

    2004-01-01

    Con la finalidad de observar las variaciones en las dimensiones del epitelio y su capa córnea, así como el grado de queratinización de la mucosa palatina por el uso de prótesis completa, se realizó un estudio en seis pacientes edéntulos totales no portadores de prótesis completa. Se realizaron biopsias de la mucosa palatina antes de al confección y 60 días después de la instalación de las prótesis completas. Las muestras biopsiadas fueron fijadas en formol neutro y coloreadas con hematoxilina...

  13. Histopatologia das lâminas do casco de equinos com laminite aguda induzida e tratados com ketoprofeno, fenilbutazona e flunixin meglumine Histopathology of the digital laminae from horses with acute induced laminitis treated with ketoprophen, phenylbutazone, and flunixin meglumin

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    F.O. Paes Leme

    2010-04-01

    Full Text Available Avaliaram-se as alterações histológicas do tecido laminar, obtido por biopsia, em 20 equinos portadores de laminite induzida por sobrecarga de carboidratos e tratados com ketoprofeno, fenilbutazona ou flunixin meglumine. A biopsia foi colhida dos dígitos torácicos 72 horas após a indução. Os achados histológicos foram comparados com os achados de amostras de equinos isentos de laminite. Infiltrado inflamatório neutrofílico foi observado em 80%, congestão em 50%, hemorragia em 35% e hiperplasia na túnica íntima das arteríolas das lâminas dérmicas primárias em 15% das amostras. As taxas de microtrombos e coágulos foram 15% e 20%, respectivamente. Estes achados parecem decorrer dos distúrbios circulatórios que ocasionaram edema, congestão e hiperemia, seguidos de degeneração. Em 70% das análises realizadas nos animais tratados, as lesões histológicas foram inferiores aos graus de claudicação observados. Conclui-se que a biopsia de tecido laminar digital de equinos é viável, os artefatos decorrentes da técnica de biopsia não prejudicam a análise histológica das amostras e os anti-inflamatórios não esteroidais não são capazes de evitar as lesões laminares quando administrados após o início da sintomatologia clínica de laminite.Experimental laminitis caused by carbohydrate overload was induced in 20 healthy horses. Seventy two hours after induction, samples of the laminar tissue were obtained by biopsy from the thoracic limbs digits for histopathology. The histological findings were compared to samples from horses without laminitis. Neutrophilic infiltrate was observed in 80% of the samples, congestion in 50%, hemorrhage in 35%, and hyperplasia of the arteriolar intima layer of the primary dermal lamina in 15%. Thrombi and intravascular blood clots were observed in 15% and 20% of the samples, respectively. Apparently, these findings were due to circulatory changes that resulted in edema, congestion, and

  14. Proteinosis alveolar pulmonar y patrón en empedrado ("crazy-paving" en tomografía computarizada de alta resolución

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    C. de Arriba

    Full Text Available Se presenta un caso de proteinosis alveolar pulmonar en un varón de 27 años en el que la tomografía computarizada de alta resolución muestra un típico patrón "crazy-paving" o en empedrado, siendo esta prueba la que orienta hacia un diagnóstico diferencial concreto, a pesar de la inespecificidad de la presentación clínica. El lavado broncoalveolar no es concluyente y el diagnóstico definitivo se hace con biopsia transbronquial. Se revisan los aspectos más característicos de esta rara enfermedad y del patrón "crazy-paving" o en empedrado en la tomografía computarizada de alta resolución.

  15. Displasias y tumores de la glándula mamaria: su diagnostico por los rayos x

    OpenAIRE

    Andrade Valderrama, Ernesto; Vargas Barrero, Enrique

    2011-01-01

    1) Recomendamos la clasificación del Gershon-Gohen e Ingleby de las afecciones benignas o displasias, por estar basada en la radiología y la anatomía patológica. 2) En el cáncer del seno, la radiografía es complemento muy útil del diagnóstico. También lo es para su pronóstico por los datos que pueden dar relacionados con infiltración e invasión posteriores. 3) El diagnóstico radiológico negativo para cáncer, no excluye la extirpación biopsia de la lesión, pero sí en la mayoría de los casos de...

  16. Actinomicose pulmonar simulando tumor de Tobias-Pancoast

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    Amanda Nogueira Barbosa Dantas Teixeira

    2011-04-01

    Full Text Available A actinomicose é uma infecção rara que pode envolver diversos órgãos. O envolvimento torácico é incomum (10-20%. No presente trabalho, é descrito o caso de um paciente de 33 anos, HIV negativo, com dor torácica posterior à esquerda em queimação com irradiação para membro superior esquerdo e diminuição da força com parestesias. A tomografia computadorizada evidenciou uma massa em contato com a parede torácica. Após realização de toracotomia foi visualizada lesão pulmonar sólida vascularizada aderida no lobo superior esquerdo, infiltrando a parede torácica posterior e ápice da cavidade. A biopsia incisional da lesão e o estudo microbiológico evidenciaram actinomicose.

  17. Blastomicosis oral, papilomatosis laríngea y tuberculosis esofágica Oral blastomycosis, laryngeal papillomatosis and esophageal tuberculosis

    OpenAIRE

    Manuel Montoya; Robert Chumbiraico; Melvin Ricalde; Ernesto Cazorla; Gustavo Hernández-Córdova

    2012-01-01

    El compromiso esofágico es una complicación infrecuente de la tuberculosis incluso en países con alta prevalencia de infección. Se presenta el caso de un paciente de 57 años no seropositivo al virus de inmunodeficiencia humana (VIH), con diagnóstico simultáneo de blastomicosis en cavidad oral y papilomatosis laríngea, ambas confirmadas por anatomía patológica. La biopsia de esófago reveló esofagitis granulomatosa con necrosis; la tinción de Ziehl-Neelsen mostró bacilos ácido-alcohol resistent...

  18. Diagnóstico y marcadores moleculares del potencial maligno de la leucoplasia oral: una revisión

    OpenAIRE

    Rebolledo Cobos, Martha; Ricardo, Jonathan Harris; Rincón Osorio, Jason

    2014-01-01

    El término leucoplasia oral (lo) es estrictamente clínico y atribuye a una lesión predominantemente blanca con patrones clínicos e histológicos de características neoplásicas, en asociación común a hábito tabáquico. Debido a esto se propone un diagnóstico provisional de leucoplasia concluyendo con una evaluación de histopatología por medio de una biopsia para confirmación y determinación del grado de displasia epitelial, el cual lleva a determinar y plantear objetivamente una terapéutica con ...

  19. Micosis fungoide: reporte de un caso clínico

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    Gabriel Abudinén A

    2010-01-01

    Full Text Available La micosis fungoide es una neoplasia maligna originada en los linfocitos T que compromete la piel pudiendo extenderse a médula ósea, linfocitos sanguíneos, ganglios linfáticos y diversos órganos internos. Se presenta el caso de un paciente de 32 años de edad, sexo masculino, que desde hace aproximadamente 1 año presenta lesiones eritematodescamativas pruriginosas inicialmente localizadas en extremidades inferiores y que luego se generalizan, asociándose a baja de peso de aproximadamente 20 Kg. Ha usado corticoides y antihistamínicos, con regular respuesta. Se inicia su estudio por eritrodermia confirmándose por biopsia el diagnóstico de micosis fungoide. Se deriva para iniciar tratamiento específico con Fototerapia con Luz Ultravioleta A (PUVA.

  20. Principios de ENDOSCOPIA diagnóstica y terapéutica (endocirugía

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    Flores-Alés, Andrés J.

    2010-09-01

    Full Text Available ResumenSe hace una introducción general a las bases, terminología, material y a las indicaciones de interés practico en la clínica diaria, con especial incapie en las tomas de biopsias, cuerpos extraños, polipectomias y en menor grado en la dilatación de de estenosis y las gastrotomía percutánea endoscópica todas ellas abarcables bajo el concepto de endocirugía, finalizando con el informe endoscópico.SummaryThe meaning of the term is defined traqueobroncoscopia describing itself the necessary material, its utility in the diagnosis, its indications, the used technique, the preparation of instruments and the patient, the exploratory routine remembering the direction endoscópica anatomy to end up concluding with the benefits that contribute.

  1. Atypical presentations of celiac disease

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    Balasa Adriana Luminita

    2016-08-01

    Full Text Available In this study we evaluated the association of celiac disease in 81 children with autoimmune disease and genetic syndromes over a two years periods (January 2014 to July 2016 in Pediatric Clinic in Constanta. Because the extraintestinal symptoms are an atypical presentation of celiac disease we determined in these children the presence of celiac disease antibodies: Anti-tissue Transglutaminase Antibody IgA and IgA total serum level as a screening method followeds in selective cases by Anti-tissue Transglutaminase Antibody IgG, anti-endomysial antibodies, deamidated gliadin antibodies IgA and IgG and intestinal biopsia. In our study 8 patients had been diagnosed with celiac disease with extraintestinal symptoms, of which 4 with type 1 diabetes, 1 patient with ataxia, 2 patients with dermatitis herpetiformis and 1 patient with Down syndrome that associate also autoimmune thyroiditis, alopecia areata, enamel hypoplasia.

  2. Contribuição para o diagóstico diferencial da distrofia muscular progressiva

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    José Antonio Levy

    1964-06-01

    Full Text Available Os dados fornecidos pela anamnese assim como a sintomatologia nem sempre permitem estabelecer, com segurança, o diagnóstico de distrofia muscular progressiva (DMP; o diagnótico é facilitado quando são obtidos dados heredológicos depondo por afecção de caráter familiar ou quando se trate de casos de longa evolução, mostrando a característica fundamental da irreversibilidade. As provas laboratoriais propostas até agora, embora úteis para a avaliação do estado da consunção do tecido muscular, não fornecem elementos seguros para o diagnóstico diferencial, pois os resultados podem ser idênticos tanto na DMP (especialmente nas fases, iniciais ou de evolução subaguda como nas polimiosites e nas neuromiosites. De grande importância para o diagnóstico diferencial são a eletromio-grafia e a biopsia muscular: a eletromiografia mostra, na DMP, diminuição da voltagem e redução da duração média dos potenciais de ação, com elevada incidência de potenciais polifásicos; o exame histológico mostra grande variação no calibre e degeneração das fibras musculares com proliferação de tecido conjuntivo, sem infiltrações de caráter inflamatório e sem atividade regenerativa útil. Entretanto, êstes exames complementares não bastam, por si sós, para o diagnóstico diferencial de todos os casos e seus resultados devem ser interpretados cuidadosamente. Neste trabalho são referidos 21 casos que exigiram cuidadoso diagnóstico diferencial. Em 17 (casos 1 a 17, com base na anamnese e na sintomatologia, fôra feito o diagnóstico de DMP; entretanto em todos êles o exame mais minucioso, acrescido de dados fornecidos pela eletromiografia e especialmente pela biopsia, conduziu à formulação de outro diagnóstico. Em dois casos (18 e 19, ambos de moléstia de Charcot-Marie-Tooth, o exame histo-patológico sugeria o diagnóstico de DMP. Em um caso (20 o quadro clínico sugeria DMP e o exame eletromiográfico indicava haver les

  3. Quiste gigante de ovario

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    Dagoberto Calderón Rodríguez

    2014-08-01

    Full Text Available Un crecimiento quístico del ovario debe medir por lo menos 2,5 cm de diámetro para denominarse quiste. Se presenta el caso de una paciente de 36 años, femenina, perteneciente a la etnia Wayú, con un quiste gigante en ovario derecho, de aproximadamente 10 cm de diámetro, un peso de 3,6 Kg y torcido sobre su pedículo, que le provoca dolor intenso de más de un mes de evolución. Se practicó intervención quirúrgica y se comprobaron signos macroscópicos de necrobiosis de ovario, siendo el resultado de la biopsia un teratoma maduro. Su resultado final fue satisfactorio

  4. Tuberculosis peritoneal con niveles elevados de CA 125

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    Andrés José Gómez-Aldana

    2013-09-01

    Full Text Available Resumen La tuberculosis peritoneal hace parte de los diagnósticos diferenciales de ascitis; sin embargo, su documentación está dada por la presencia de granulomas necrotizantes al igual que el crecimiento de micobacterias en las muestras tomadas del peritoneo. Se presenta el caso de una paciente con dolor abdominal y ascitis en quien se documentaron lesiones nodulares en cavidad peritoneal, con niveles marcadamente elevados de "Antígeno Carbohidrato o Antígeno Cáncer" CA 125, sin cambios en otros órganos, realizando biopsias de peritoneo, con documentación de granulomas necrotizantes y crecimiento de micobacterias en el cultivo, por lo que se instauró tratamiento con adecuada respuesta logrando disminución progresiva de la ascitis y ganancia de peso.

  5. Modulación en la expresión de biomarcadores (RE, RP y C-erbB2 en cáncer de mama tras tratamiento neoadyuvante Modulation of biomarkers expression (OR, PR and C-erbB2 in breast cancer following neoadjuvant treatment

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    A. Córdoba

    2006-12-01

    Full Text Available Introducción: El tratamiento oncológico pre y postoperatorio en pacientes con carcinoma de mama está condicionado entre otros factores, por el resultado del estudio inmunohistoquímico de los receptores hormonales y por la expresión de c-erbB2. El objetivo del estudio es determinar la influencia del tratamiento neoadyuvante en la expresión de receptores de estrógeno (RE, progesterona (PR y c-erbB2. Material y métodos. Estudiamos 53 pacientes con cáncer de mama diagnosticadas mediante biopsia "trucut". Las pacientes con carcinoma localmente avanzado (20 se someten a quimioterapia preoperatoria. Se realiza extirpación quirúrgica en todos los casos. Comparamos la expresión de receptores de estrógeno (RE, receptores de progesterona (PR y c-erbB2, en la biopsia"trucut" y en la pieza quirúrgica. Resultados. Encontramos diferencias significativas en la expresión de RE, RP entre biopsia/pieza quirúrgica, comparando el grupo de pacientes sometidas a tratamiento neoadyuvante frente al grupo de pacientes sin tratamiento oncológico prequirúrgico. Encontramos diferencias de signo (positivización y negativización entre un 10 y un 40% de casos en la expresión inmunohistoquímica para RE, RP y c-erbB2 entre la biopsia"trucut" y la resección quirúrgica en las pacientes tratadas con neoadyuvancia. Estas diferencias de signo no tienen significación estadística.Introducción: Pre and post-operative oncological therapy in patients with breast cancer is determined, amongst other factors, by hormone receptor status and by c-erbB2 expression. The aim of this study is to determine the influence of neoadjuvant therapy on the expression of oestrogen receptor (OR, progesterone receptor (PR and c-erbB2. Methods. Fifty-three patients with breast cancer diagnosed by tru-cut biopsy were studied. Patients with locally advanced carcinoma (20 had preoperative treatment. All patients underwent surgical resection. Expression of OR, PR and c-erbB2 in both the

  6. Factores de recurrencia de las lesiones de alto grado de cuello uterino tras extirpación completa con márgenes negativos

    OpenAIRE

    Doyagüe Sánchez, María José

    2016-01-01

    [ES] La relación etimológica entre las infecciones por HPV y los tumores genitales constituye uno de los avances mas significativos en relación a la etiología del cáncer de cérvix. La evolución de las infecciones genitales por HPV van desde la eliminación espontánea a la presencia de Lesiones Intraepiteliales de Bajo Grado a las de Alto Grado a Cáncer de Cérvix. El diagnóstico de las lesiones se basa en el uso de la Citología, genómica HPV, Colposcopia y biopsia- anatomía patológica. El Trat...

  7. La enfermedad de Kimura: comunicación de un caso en un varón caucásico y revisión de la literatura Kimura disease: Report of a case in a Caucasian male and revision of the literature

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    J.M. López-Arcas Calleja

    2006-12-01

    Full Text Available La enfermedad de Kimura es un trastorno inflamatorio que afecta principalmente a sujetos de origen asiático. Se manifiesta por la existencia de masas de tejido subcutáneo y subplatismal generalmente en la cabeza y el cuello. Suele acompañarse de linadenopatías, y aumento de los niveles de eosinófilos e IgE en sangre periférica. Comunicamos un caso de enfermedad de Kimura, descubierto en un varón caucasiano, tras una biopsia excisional de una masa cervical.Kimura disease is a chronic inflammatory disorder mainly involving Asians. It often presents as soft-tissue nodes or lymphadenopathy of the head and neck. Commonly associated with increased levels of eosinophils and IgE in peripheral blood. We report a case of Kimura disease in a Caucasian, diagnosed after lymph node and submaxillary gland removal.

  8. Encefalitis a citomegalovirus en un paciente inmunocompetente: análisis clinico, neuropatologico y ultraestructural

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    Salamano Ronald

    2001-01-01

    Full Text Available Las encefalitis por citomegalovirus en pacientes inmunocompetentes son excepcionales, siendo un patógeno reconocido en pacientes inmunodeprimidos (SIDA, transplantados. Se reporta el caso clínico de una encefalitis por Citomegalovirus en un adulto joven, sin evidencia de enfermedad inmunosupresora, cuyo diagnóstico fue posible mediante la detección de ADN viral en la biopsia cerebral. Se describen además las singularidades clínicas de este caso y los hallazgos de la anatomía patológica y de la microscopía electrónica comparándolos con los reportados en pacientes inmunodeprimidos.

  9. Comparação dos anticorpos anti-reticulina e antiendomísio classe IGA para diagnóstico e controle da dieta na doença celíaca Comparison of IgA class reticulin and endomysium antibodies for diagnosis and control of the diet in celiac disease

    OpenAIRE

    KOTZE,Lorete Maria da Silva; Shirley Ramos da Rosa UTIYAMA; Renato Mitsunori NISIHARA; Mocelin, Valmir; CARVALHO,Roberta Ferreira de Andrade; Márgara Patrícia Bini ZENI; AMARANTE,Heda Maria Santos

    1999-01-01

    Sensibilidade ao glúten é um estado de elevada resposta iamunológica (celular e humoral) à ingestão de proteínas do glúten do trigo, centeio, cevada e aveia, em indivíduos geneticamente predispostos. A doença celíaca é sua expressão mais freqüente, variando as formas de apresentação. Tem como tratamento a exclusão de alimentos contendo as gliadinas tóxicas. Embora a biopsia do intestino delgado proximal seja necessária, tem-se ressaltado a importância de testes sorológicos no rastreamento, di...

  10. Hallazgo casual de un linfoma no Hodgkin en la base de la lengua

    OpenAIRE

    Tavárez Rodríguez, Juan José; Benito Orejas, José Ignacio; Morais Pérez, Darío; Trueba Arguiñarena, Javier

    2013-01-01

    [ES] Presentamos el caso clínico de un varón de 65 años, al que descubrimos de forma casual una tumoración submucosa en la amígdala lingual, cuyo diagnóstico pudo realizarse mediante una punción/biopsia con aguja gruesa guiada por ecografía. La evaluación anatomo-patológica demostraba la existencia de un linfoma no Hodgkin de fenotipo B. El estudio de extensión clasificaba al proceso de Estadio I-A y el tratamiento inicial fue con radioterapia local.Justifican esta publicación, el escaso núme...

  11. Tiroiditis autoinmune inducida por interferón en pacientes con infección por virus de la hepatitis C. Interferon-induced autoimmune thyroiditis in a patient with hepatitis C virus infection

    OpenAIRE

    Pinto, José L.; Miguel E. Pinto

    2011-01-01

    Se reporta el caso de un varón de 43 años de edad, sin antecedentes patológicos de importancia, que acudió por elevación asintomática de la alanino aminotransferasa (ALT). El paciente negó ser bebedor crónico de alcohol. Se hizo el diagnóstico serológico de infección activa por hepatitis C y la biopsia de hígado reveló inflamación crónica activa. Con estos resultados, se inició tratamiento con interferón-alfa y ribavirina. Durante el tratamiento de 48 semanas, el paciente presentó anticuerpos...

  12. Porocarcinoma ecrino en asociación con tricoepitelioma en una lesión tumoral única, reporte de un caso

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    Pablo Aguilera Huerta

    2010-01-01

    Full Text Available Hombre de 78 años, presenta tumor exofítico en zona frontal de crecimiento acelerado. Se le realiza biopsia que informa una neoplasia maligna de anexo cutáneo, consistente con poroma ecrino maligno. Se extirpa quirúrgicamente la lesión, informándose a la anatomía patológica una lesión correspondiente a un poroma ecrino maligno asociado a zonas de tricoepitelioma. El porocarcinoma es una neoplasia cutánea rara que se origina en la porción ductal intraepidérmica de las glándulas ecrinas. Se presenta en pacientes entre la quinta y octava década de la vida y evoluciona lentamente. Tiene potencial metastásico, puede recidivar e invadir tempranamente los vasos linfáticos dérmicos.

  13. Actualización sobre estreñimiento crónico funcional en niños

    OpenAIRE

    Carlos Alberto Velasco

    2005-01-01

    El estreñimiento crónico es un problema frecuente en la edad pediátrica; 95% de los casos es funcional, es decir, no debido a causas orgánicas, anatómicas o por ingesta de alimentos. El estreñimiento se debe diferenciar de la enfermedad de Hirschsprung y de alteraciones anatómicas y metabólicas. La evaluación clínica incluye una historia clínica completa, examen físico adecuado y paraclínicos como radiología, manometría anorrectal y biopsia rectal. El manejo incluye cambios en el medio ambien...

  14. Desintegración de las praxias en la enfermedad de Alzheimer

    Directory of Open Access Journals (Sweden)

    Carlos A. Bardeci

    1972-03-01

    Full Text Available Se describe la sintomatologia clínica, los resultados de métodos auxiliares y de la punción biopsia cerebral de una paciente con enfermedad de Alzheimer. Se analizan los diversos aspectos clínicos, sosteniendose como posible determinar la individualidad clínica de la enfermedad de Alzheimer, dentro del capítulo de las demencias preseniles y su diagnóstico en vida. Las formas de apraxia presentes en esta observación confirman la correlación estrecha que existe entre los distintos niveles de su desintegración, à su relación con las perturbaciones del espacio al cual están genéticamente vinculadas; el espacio euclidiano para la apraxia constructiva, el espacio centrado en el propio cuerpo para la ideomotora y el concreto de manipulación de objetos para la ideatoria.

  15. Compromiso nodular hepático secundario a mieloma múltiple

    Directory of Open Access Journals (Sweden)

    Fernando J. Vázquez

    2010-08-01

    Full Text Available El mieloma múltiple (MM es una enfermedad maligna caracterizada por una proliferación clonal de células plasmáticas atípicas en la médula ósea, que produce una inmunoglobulina (Ig con estructura homogénea en la sangre y/o en la orina (cadenas livianas. El compromiso del parénquima hepático con masa ocupante en los pacientes con MM es excepcional. Describimos 3 casos clínicos confirmados histológicamente. La ecografía y la tomografía computarizada tienen una sensibilidad intermedia y las imágenes no son patognomónicas, por lo tanto es necesaria la confirmación a través de la biopsia. Se desconoce la implicancia pronóstica de este hallazgo.

  16. Características clínicas, bioquímicas y epidemiológicas de un grupo de pacientes con diagnóstico imaginológico de hígado graso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Restrepo

    2001-04-01

    Full Text Available En nuestro medio, la esteatosis o infiltración hepática grasa se
    convierte casi siempre en un hallazgo imaginológico incidental, al cual
    se la da muy poca importancia desde el punto de vista clínico, y por
    ende no se realizan estudios posteriores para determinar su causa, las condiciones asociadas que lo expliquen (1, y mucho menos se realiza biopsia hepática para determinar, cuáles de estos pacientes tienen esteatohepatitis, algún grado de fibrosis o incluso cirrosis. Este trabajo tuvo como objetivo describir las características epidemiológicas, clínicas y bioquímicas de un grupo de pacientes con diagnóstico imaginológico de hígado graso.

  17. Asociación de Helicobacter pylori y patología gástrica no neoplásica en una clínica privada de Lima Norte.

    OpenAIRE

    SALAS SANCHEZ, Willy Alfredo; BENITES GALVEZ, Maria del Rosario; SALINAS CERQUIN, César

    2013-01-01

    Objetivo: Determinar la asociación entre la infección de Helicobacter pylori (HP) y los hallazgos histológicos de las BGNPN. Materiales y métodos: Se realizó el estudio descriptivo retrospectivo en las BGNPN realizadas por endoscopía digestiva alta en el Servicio de Gastroenterología de la Clínica Médica Cayetano Heredia del 1º de enero de 1999 al 31 de julio del 2002. Resultados: Se revisaron 676 biopsias gástricas negativas a patología neoplásica. La edad promedio fue 45,12 años. No hubo pr...

  18. Un caso excepcional de disnea y disfagia

    Directory of Open Access Journals (Sweden)

    Javier Moreno Díaz

    2015-12-01

    Full Text Available Se presenta un caso de una mujer de 43 años, valorada por un cuadro insidioso de disnea progresiva con odinofagia. Tras las primeras evaluaciones por el servicio de Otorrinolaringología, se realiza biopsia a través de fibrobroncoscopia de lesiones obeservadas en epiglotis. La anatomía patológica de la lesión confirmó la presencia de bacilos de Mycobacterium tuberculosis. Las formas clásicas de tuberculosis laríngea muestran estadíos avanzados de lesiones pulmonares y afectación clínica grave, siendo raros los casos de afectación paucisintomática.

  19. Fulminant form of multiple sclerosis simulating brain tumor: A case with parkinsonian features and pathologic study Forma fulminante de esclerose múltipla simulando tumor cerebral: um caso com sinais parkinsonianos e estudo patológico

    Directory of Open Access Journals (Sweden)

    Pa. Maranhão-Filho

    1995-09-01

    Full Text Available We describe the case of a 48 year- old man in whom the clinical features, CT and MR scans were suggestive of a brain tumor but, posteriorly, another MRI study, CSF examination and brain biopsy supported the diagnosis of multiple sclerosis. Interestingly, this patient presented parkinsonian features, probably in connection with the underlying disease.Os autores descrevem o caso de um paciente com 48 anos de idade cujos sinais e sintomas, TC e RM foram sugestivos de tumor cerebral mas, posteriormente, nova RM, estudo do LCR e biopsia cerebral sustentaram o diagnóstico de esclerose múltipla. Curiosamente, no transcurso da enfermidade este paciente apresentou parkinsonismo, provavelmente relacionado com a doença de base.

  20. Premio Aventis – Proyectos de Investigación: «Análisis de Longitud Telomérica y Actividad Telomerasa en Carcinogénesis Gástrica»

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    Humberto Arboleda

    2005-06-01

    En el estudio se incluirán pacientes que lleguen al servicio de Gastroenterología de las Clínicas Carlos Lleras y San Pedro Claver de Bogotá D.C, para realización de endoscopia de vías digestivas altas mas biopsia. Con previo consentimiento informado, se obtendrán muestras de mucosa gástrica lesionada y sana del mismo paciente la cual se utilizará como control. Además también se estudiarán especímenes quirúrgicos de pacientes de la Clínica Fundadores y el Instituto Nacional de Cancerología...