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Sample records for biomedical sciences lead

  1. Leading change: curriculum reform in graduate education in the biomedical sciences.

    Science.gov (United States)

    Dasgupta, Shoumita; Symes, Karen; Hyman, Linda

    2015-01-01

    The Division of Graduate Medical Sciences at the Boston University School of Medicine houses numerous dynamic graduate programs. Doctoral students began their studies with laboratory rotations and classroom training in a variety of fundamental disciplines. Importantly, with 15 unique pathways of admission to these doctoral programs, there were also 15 unique curricula. Departments and programs offered courses independently, and students participated in curricula that were overlapping combinations of these courses. This system created curricula that were not coordinated and that had redundant course content as well as content gaps. A partnership of key stakeholders began a curriculum reform process to completely restructure doctoral education at the Boston University School of Medicine. The key pedagogical goals, objectives, and elements designed into the new curriculum through this reform process created a curriculum designed to foster the interdisciplinary thinking that students are ultimately asked to utilize in their research endeavors. We implemented comprehensive student and peer evaluation of the new Foundations in Biomedical Sciences integrated curriculum to assess the new curriculum. Furthermore, we detail how this process served as a gateway toward creating a more fully integrated graduate experience, under the umbrella of the Program in Biomedical Sciences.

  2. Holography In Biomedical Sciences

    Science.gov (United States)

    von Bally, G.

    1988-01-01

    Today not only physicists and engineers but also biological and medical scientists are exploring the potentials of holographic methods in their special field of work. Most of the underlying physical principles such as coherence, interference, diffraction and polarization as well as general features of holography e.g. storage and retrieval of amplitude and phase of a wavefront, 3-d-imaging, large field of depth, redundant storage of information, spatial filtering, high-resolving, non-contactive, 3-d form and motion analysis are explained in detail in other contributions to this book. Therefore, this article is confined to the applications of holography in biomedical sciences. Because of the great number of contributions and the variety of applications [1,2,3,4,5,6,7,8] in this review the investigations can only be mentioned briefly and the survey has to be confined to some examples. As in all fields of optics and laser metrology, a review of biomedical applications of holography would be incomplete if military developments and their utilization are not mentioned. As will be demonstrated by selected examples the increasing interlacing of science with the military does not stop at domains that traditionally are regarded as exclusively oriented to human welfare like biomedical research [9]. This fact is actually characterized and stressed by the expression "Star Wars Medicine", which becomes increasingly common as popular description for laser applications (including holography) in medicine [10]. Thus, the consequence - even in such highly specialized fields like biomedical applications of holography - have to be discussed.

  3. Leading Change: Curriculum Reform in Graduate Education in the Biomedical Sciences

    Science.gov (United States)

    Dasgupta, Shoumita; Symes, Karen; Hyman, Linda

    2015-01-01

    The Division of Graduate Medical Sciences at the Boston University School of Medicine houses numerous dynamic graduate programs. Doctoral students began their studies with laboratory rotations and classroom training in a variety of fundamental disciplines. Importantly, with 15 unique pathways of admission to these doctoral programs, there were…

  4. Optimizing biomedical science learning in a veterinary curriculum: a review.

    Science.gov (United States)

    Warren, Amy L; Donnon, Tyrone

    2013-01-01

    As veterinary medical curricula evolve, the time dedicated to biomedical science teaching, as well as the role of biomedical science knowledge in veterinary education, has been scrutinized. Aside from being mandated by accrediting bodies, biomedical science knowledge plays an important role in developing clinical, diagnostic, and therapeutic reasoning skills in the application of clinical skills, in supporting evidence-based veterinary practice and life-long learning, and in advancing biomedical knowledge and comparative medicine. With an increasing volume and fast pace of change in biomedical knowledge, as well as increased demands on curricular time, there has been pressure to make biomedical science education efficient and relevant for veterinary medicine. This has lead to a shift in biomedical education from fact-based, teacher-centered and discipline-based teaching to applicable, student-centered, integrated teaching. This movement is supported by adult learning theories and is thought to enhance students' transference of biomedical science into their clinical practice. The importance of biomedical science in veterinary education and the theories of biomedical science learning will be discussed in this article. In addition, we will explore current advances in biomedical teaching methodologies that are aimed to maximize knowledge retention and application for clinical veterinary training and practice.

  5. Los Alamos Life Sciences Division's biomedical and environmental research programs. Progress report, January-December 1981. [Leading abstract

    Energy Technology Data Exchange (ETDEWEB)

    Holland, L.M.; Stafford, C.G. (comps.)

    1982-10-01

    This report summarizes research and development activities of the Los Alamos Life Sciences Division's Biomedical and Environmental Research program for the calendar year 1981. Individual reports describing the current status of projects have been entered individually into the data base.

  6. Terahertz biomedical science and technology

    CERN Document Server

    Son, Joo-Hiuk

    2014-01-01

    Introduction to Biomedical Studies Using Terahertz WavesJoo-Hiuk SonSection I Terahertz TechnologyTerahertz Sources and DetectorsHyunyong Choi and Joo-Hiuk SonTabletop High-Power Terahertz Pulse Generation TechniquesYun-Shik LeeTerahertz Imaging and Tomography TechniquesHyunyong Choi and Joo-Hiuk SonCompact Solid-State Electronic Terahertz Devices and CircuitsJae-Sung Rieh, Daekeun Yoon, and Jongwon Yun<

  7. Application of infrared to biomedical sciences

    CERN Document Server

    Etehadtavakol, Mahnaz

    2017-01-01

    The book covers the latest updates in the application of infrared to biomedical sciences, a non-invasive, contactless, safe and easy approach imaging of skin and tissue temperatures. Its diagnostic procedure allows practitioners to identify the locations of abnormal chemical and blood vessel activity such as angiogenesis in body tissue. Its non-invasive approach works by applying the technology of the infrared camera and state-of-the-art software, where high-resolution digital infrared imaging technology benefits highly from enhanced image production, standardized image interpretation protocols, computerized comparison and storage, and sophisticated image enhancement and analysis. The book contains contributions from global prominent scientists in the area of infrared applications in biomedical studies. The target audience includes academics, practitioners, clinicians and students working in the area of infrared imaging in biomedicine.

  8. Dielectrophoresis for Biomedical Sciences Applications: A Review

    Directory of Open Access Journals (Sweden)

    Nurhaslina Abd Rahman

    2017-02-01

    Full Text Available Dielectrophoresis (DEP is a label-free, accurate, fast, low-cost diagnostic technique that uses the principles of polarization and the motion of bioparticles in applied electric fields. This technique has been proven to be beneficial in various fields, including environmental research, polymer research, biosensors, microfluidics, medicine and diagnostics. Biomedical science research is one of the major research areas that could potentially benefit from DEP technology for diverse applications. Nevertheless, many medical science research investigations have yet to benefit from the possibilities offered by DEP. This paper critically reviews the fundamentals, recent progress, current challenges, future directions and potential applications of research investigations in the medical sciences utilizing DEP technique. This review will also act as a guide and reference for medical researchers and scientists to explore and utilize the DEP technique in their research fields.

  9. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    1987-05-13

    1880Ü JPRS-UBB-87-OlO 13 MAY 1987 USSR Report LIFE SCIENCES BIOMEDICAL AND BEHAVIORAL SCIENCES DISTRIBUTION STATEMENT I App*w#d lot pubfe...Preirradiation Status and Site of Irradiation (N.P. Didenko, V.M. Perelmuter, et al.; BIOFIZIKA, No 5, Sep-Oct 86) 41 Effects of Nonionizing Microwave ...20026 radiometer (GDR) as a scaling unit. Regression equations were calculated for the controlr and experimental groups were calculated based on

  10. Biomedical and Environmental Sciences INFORMATION FOR AUTHORS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Biomedical and Environmental Sciences, an international journal with emphasis on scientific findings in China, publishes articles dealing with biologic and toxic effects of environmental pollutants on man and other forms of life. The effects may be measured with pharmacological, biochemical, pathological, and immunological techniques. The journal also publishes reports dealing with the entry, transport, and fate of natural and anthropogenic chemicals in the biosphere, and their impact on human health and well-being.Papers describing biochemical, pharmacological, pathological, toxicological and immunological studies of pharmaceuticals (biotechnological products) are also welcome.

  11. Signal and image analysis for biomedical and life sciences

    CERN Document Server

    Sun, Changming; Pham, Tuan D; Vallotton, Pascal; Wang, Dadong

    2014-01-01

    With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in t

  12. Modeling and control in the biomedical sciences

    CERN Document Server

    Banks, H T

    1975-01-01

    These notes are based on (i) a series of lectures that I gave at the 14th Biennial Seminar of the Canadian Mathematical Congress held at the University of Western Ontario August 12-24, 1973 and (li) some of my lectures in a modeling course that I have cotaught in the Division of Bio-Medical Sciences at Brown during the past several years. An earlier version of these notes appeared in the Center for Dynamical Systems Lectures Notes series (CDS LN 73-1, November 1973). I have in this revised and extended version of those earlier notes incorporated a number of changes based both on classroom experience and on my research efforts with several colleagues during the intervening period. The narrow viewpoint of the present notes (use of optimization and control theory in biomedical problems) reflects more the scope of the CMC lectures given in August, 1973 than the scope of my own interests. Indeed, my real interests have included the modeling process itself as well as the contributions made by investiga­ tors who e...

  13. The Impact of Regulating Social Science Research with Biomedical Regulations

    Science.gov (United States)

    Durosinmi, Brenda Braxton

    2011-01-01

    The Impact of Regulating Social Science Research with Biomedical Regulations Since 1974 Federal regulations have governed the use of human subjects in biomedical and social science research. The regulations are known as the Federal Policy for the Protection of Human Subjects, and often referred to as the "Common Rule" because 18 Federal…

  14. Theory and experiment in biomedical science

    Science.gov (United States)

    Allen, Roland

    2012-10-01

    A physicist might regard a person as a collection of electrons and quarks, and a biologist might regard her as an assemblage of biochemical molecules. But according to some speakers at a recent Welch conference [1] biology is a branch of physics. Then biomedical research is a branch of applied physics. Even if one adopts a more modest perspective, it is still true that physics can contribute strongly to biomedical research. An example on the experimental side is the recent studies of G protein-coupled receptors (targeted by more than 50 percent of therapeutic drugs) using synchrotron radiation and nuclear magnetic resonance. On the theory side, one might classify models as microscopic (e.g., simulations of molecules, ions, or electrons), mesoscopic (e.g., simulations of pathways within a cell), or macroscopic (e.g., calculations of processes involving the whole body). We have recently introduced a new macroscopic method for estimating the biochemical response to pharmaceuticals, surgeries, or other medical interventions, and applied it in a simple model of the response to bariatric surgeries [2]. An amazing effect is that the most widely used bariatric surgery (Roux-en-Y-gastric bypass) usually leads to remission of type 2 diabetes in days, long before there is any significant weight loss (with further beneficial effects in the subsequent months and years). Our results confirm that this effect can be largely explained by the enhanced post-meal excretion of glucagon-like peptide 1 (GLP-1), an incretin that increases insulin secretion from the pancreas, but also suggest that other mechanisms are likely to be involved, possibly including an additional insulin-independent pathway for glucose transport into cells. [4pt] [1] Physical Biology, from Atoms to Medicine, edited by Ahmed H. Zewail (Imperial College Press, London, 2008).[0pt] [2] Roland E. Allen, Tyler D. Hughes, Jia Lerd Ng, Roberto D. Ortiz, Michel Abou Ghantous, Othmane Bouhali, Abdelilah Arredouani

  15. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    academician, Ukrainian SSSR Academy of Sciences, Physicochemical Institute, Ukrainian SSR Academy of Sciences, Odessa [Abstract] Polyacrylamide gel (PAAG...the canned chicken and beef products. For example, it has been demonstrated that one of the common additives in pediatric products, starch ... starch products may react with proteins leading to the formation of polycondensation products and eliminating 20-50% of the free amino acids in the

  16. Biomedical Applications of NASA Science and Technology

    Science.gov (United States)

    Brown, James N., Jr.

    1968-01-01

    During the period 15 September 1968 to 14 December 1968, the NASA supported Biomedical Application Team at the Research Triangle Institute has identified 6 new problems, performed significant activities on 15 of the active problems identified previously, performed 5 computer searches of the NASA aerospace literature, and maintained one current awareness search. As a partial result of these activities, one technology transfer was accomplished. As a part of continuing problem review, 13 problems were classified inactive. Activities during the quarter involved all phases of team activity with respect to biomedical problems. As has been observed in preceding years, it has been exceedingly difficult to arrange meetings with medical investigators during the fourth quarter of the calendar year. This is a result of a combination of factors. Teaching requirements, submission of grant applications and holidays are the most significant factors involved. As a result, the numbers of new problems identified and of transfers and potential transfers are relatively low during this quarter. Most of our activities have thus been directed toward obtaining information related to problems already identified. Consequently, during the next quarter we will follow up on these activities with the expectation that transfers will be accomplished on a number of them. In addition, the normal availability of researchers to the team is expected to be restored during this quarter, permitting an increase in new problem identification activities as well as follow-up with other researchers on old problems. Another activity scheduled for the next quarter is consultation with several interested biomedical equipment manufacturers to explore means of effective interaction between the Biomedical Application Team and these companies.

  17. Publications in biomedical and environmental sciences programs, 1980

    Energy Technology Data Exchange (ETDEWEB)

    Pfuderer, H.A.; Moody, J.B.

    1981-07-01

    This bibliography contains 690 references to articles in journals, books, and reports published in the subject area of biomedical and environmental sciences during 1980. There are 529 references to articles published in journals and books and 161 references to reports. Staff members in the Biomedical and Environmental Sciences divisions have other publications not included in this bibliography; for example, theses, book reviews, abstracts published in journals or symposia proceedings, pending journal publications and reports such as monthly and bimonthly progress reports, contractor reports, and reports for internal distribution. This document is sorted by the division, and then alphabetically by author. The sorting by divisions separates the references by subject area in a simple way. The divisions represented in the order that they appear in the bibliography are Analytical Chemistry, Biology, Chemical Technology, Information R and D, Health and Safety Research, Energy, Environmental Sciences, and Computer Sciences.

  18. Evaluation of Biomedical Science Students Use and Perceptions of Podcasting

    Science.gov (United States)

    Smith, Katie; Morris, Neil P.

    2014-01-01

    The use of podcasting in higher education has escalated in recent years. The aim of this case study was to analyse undergraduate student use and perceptions of lecture audio recordings in the School of Biomedical Sciences at the University of Leeds. Students completed an online survey over a two-week period based on their use of lecture audio…

  19. Convergence of Terahertz Sciences in Biomedical Systems

    CERN Document Server

    Kim, Yong; Han, Haewook; Han, Joon; Ahn, Jaewook; Son, Joo-Hiuk; Park, Woong-Yang; Jeong, Young

    2012-01-01

    Recent technological breakthrough in the field of Terahertz radiation has triggered new applications in biology and biomedicine. Particularly, biological applications are based on the specific spectroscopic fingerprints of biological matter in this spectral region. Historically with the discovery of new electromagnetic wave spectrum, we have always discovered new medical diagnostic imaging systems. The use of terahertz wave was not realized due to the absence of useful terahertz sources. Now after successful generation of THz waves, it is reported that a great potential for THz wave exists for its resonance with bio-molecules. There are many challenging issues such as development of THz passive and active instrumentations, understanding of THz-Bio interaction for THz spectroscopy, THz-Bio nonlinear phenomena and safety guideline, and THz imaging systems. Eventually the deeper understanding of THz-Bio interaction and novel THz systems enable us to develop powerful THz biomedical imaging systems which can contr...

  20. Biomedical science postdocs: an end to the era of expansion.

    Science.gov (United States)

    Garrison, Howard H; Justement, Louis B; Gerbi, Susan A

    2016-01-01

    After >3 decades of steady growth, the number of biological and medical science postdoctorates at doctoral degree-granting institutions recently began to decline. From 2010 through 2013, the most recent survey years, the postdoctoral population decreased from 40,970 to 38,719, a loss of 5.5%. This decline represents a notable departure from the previous long-standing increases in the number of postdoctorates in the biomedical workforce. The rate of contraction appears to be accelerating in the most recent survey years, and this has important implications for the biomedical workforce.

  1. 76 FR 1212 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-01-07

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Eligibility of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... areas of biomedical, behavioral and clinical science research. The panel meeting will be open to...

  2. Research-Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment

    Science.gov (United States)

    Lorden, Joan F., Ed.; Kuh, Charlotte V., Ed.; Voytuk, James A., Ed.

    2011-01-01

    "Research Doctorate Programs in the Biomedical Sciences: Selected Findings from the NRC Assessment" examines data on the biomedical sciences programs to gather additional insight about the talent, training environment, outcomes, diversity, and international participation in the biomedical sciences workforce. This report supports an earlier…

  3. 76 FR 79273 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2011-12-21

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... Eligibility of the Joint Biomedical Laboratory Research and Development and Clinical Science Research and... biomedical, behavioral, and clinical science research. The panel meeting will be open to the public...

  4. Biomedical Engineering and Cognitive Science Secondary Science Curriculum Development: A Three Year Study

    Science.gov (United States)

    Klein, Stacy S.; Sherwood, Robert D.

    2005-01-01

    This study reports on a multi-year effort to create and evaluate cognitive-based curricular materials for secondary school science classrooms. A team of secondary teachers, educational researchers, and academic biomedical engineers developed a series of curriculum units that are based in biomedical engineering for secondary level students in…

  5. Structural biology computing: Lessons for the biomedical research sciences.

    Science.gov (United States)

    Morin, Andrew; Sliz, Piotr

    2013-11-01

    The field of structural biology, whose aim is to elucidate the molecular and atomic structures of biological macromolecules, has long been at the forefront of biomedical sciences in adopting and developing computational research methods. Operating at the intersection between biophysics, biochemistry, and molecular biology, structural biology's growth into a foundational framework on which many concepts and findings of molecular biology are interpreted1 has depended largely on parallel advancements in computational tools and techniques. Without these computing advances, modern structural biology would likely have remained an exclusive pursuit practiced by few, and not become the widely practiced, foundational field it is today. As other areas of biomedical research increasingly embrace research computing techniques, the successes, failures and lessons of structural biology computing can serve as a useful guide to progress in other biomedically related research fields.

  6. What should biomedical sciences education in dental schools achieve?

    Science.gov (United States)

    Lantz, M S; Chaves, J F

    1997-05-01

    Education for the first professional degree in dentistry is intended to produce graduates capable of offering a wide range of high quality dental services to the general public. More than that, it is expected that graduates will be firmly grounded in the scientific basis for their professional practices and be equipped to evaluate critically and integrate selectively new scientific findings that emerge during their professional lifetimes. In addition, they are expected to be able to work effectively with diverse patient populations and to conduct their practices with a high level of sensitivity to the ethical and psychosocial dimensions of patient care. Indiana University School of Dentistry has undergone a process of curriculum reform that has yielded a new first professional degree program. Its hallmarks are large, multidisciplinary courses (seven courses in the first two years) that are taught using a variety of strategies including problem-based learning in small groups as well as lectures. The biomedical sciences curriculum is concept-based. Students will demonstrate their understanding of science concepts and methods by applying them to the solution of research and health care problems. Biomedical sciences will be taught at a level that will provide a comprehensive understanding of the functioning of the human body in health and disease, allow students to assimilate the coming revolution in molecular medicine, and selectively use new diagnostics, preventives, and therapeutics that evolve as molecular biological technologies yield solutions to current medical and dental problems. Using the biomedical sciences curriculum as a vehicle, we will also achieve the goal of training dentists as critical thinkers, problem solvers, lifelong learners, and ethical practitioners, skillful in peer and self-evaluation, and cognizant of the psychosocial as well as biomedical perspective of health and disease.

  7. Life and Biomedical Sciences and Applications Advisory Subcommittee Meeting

    Science.gov (United States)

    1996-01-01

    The proceedings of the August 1995 meeting of the Life and Biomedical Sciences and Applications Advisory Subcommittee (LBSAAS) are summarized. The following topics were addressed by the Subcommittee members: the activities and status of the LBSA Division; program activities of the Office of Life and Microgravity Sciences and Applications (OLMSA); the medical Countermeasures Program; and the Fettman Report on animal research activities at ARC. Also presented were a history and overview of the activities of the Space Station Utilization Advisory Committee and the Advanced Life Support Program (ALSP). The meeting agenda and a list of the Subcommittee members and meeting attendees are included as appendices.

  8. Overview of the biomedical and environmental programs at the Oak Ridge National Laboratory. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Pfuderer, H.A.; Moody, J.B. (comps.)

    1981-07-01

    Separate abstracts were prepared for each of the 6 chapters presented by the six divisions involved in the Biomedical and Environmental Sciences Program at Oak Ridge National Laboratory. The introduction is not covered by an abstract and deals with the environmental, health and safety considerations of energy technology decisions, the major initiatives now being taken by these 6 divisions, and recent major accomplishments in the biomedical and environmental science program. (KRM)

  9. 78 FR 28292 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2013-05-14

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... areas of biomedical, behavioral and clinical science research. The panel meetings will be open to the... location changes have been made for the following panel meetings of the of the Joint Biomedical...

  10. Data science, learning, and applications to biomedical and health sciences.

    Science.gov (United States)

    Adam, Nabil R; Wieder, Robert; Ghosh, Debopriya

    2017-01-01

    The last decade has seen an unprecedented increase in the volume and variety of electronic data related to research and development, health records, and patient self-tracking, collectively referred to as Big Data. Properly harnessed, Big Data can provide insights and drive discovery that will accelerate biomedical advances, improve patient outcomes, and reduce costs. However, the considerable potential of Big Data remains unrealized owing to obstacles including a limited ability to standardize and consolidate data and challenges in sharing data, among a variety of sources, providers, and facilities. Here, we discuss some of these challenges and potential solutions, as well as initiatives that are already underway to take advantage of Big Data.

  11. Publications in biomedical and environmental sciences programs, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Moody, J.B. (comp.)

    1982-07-01

    This bibliography contains 698 references to articles in journals, books, and reports published in the subject area of biomedical and environmental sciences during 1981. There are 520 references to articles published in journals and books and 178 references to reports. Staff members in the Biomedical and Environmental Sciences divisions have other publications not included in this bibliography; for example, theses, book reviews, abstracts published in journals or symposia proceedings, pending journal publications and reports such as monthly, bimonthly, and quarterly progress reports, contractor reports, and reports for internal distribution. This document is sorted by the division, and then alphabetically by author. The sorting by divisions separates the references by subject area in a simple way. The divisions represented in the order that they appear in the bibliography are Analytical Chemistry, Biology, Chemical Technology, Information R and D, Health and Safety Research, Instrumentation and Controls, Computer Sciences, Energy, Engineering Technology, Solid State, Central Management, Operations, and Environmental Sciences. Indexes are provided by author, title, and journal reference.

  12. Life sciences biomedical research planning for Space Station

    Science.gov (United States)

    Primeaux, Gary R.; Michaud, Roger; Miller, Ladonna; Searcy, Jim; Dickey, Bernistine

    1987-01-01

    The Biomedical Research Project (BmRP), a major component of the NASA Life Sciences Space Station Program, incorporates a laboratory for the study of the effects of microgravity on the human body, and the development of techniques capable of modifying or counteracting these effects. Attention is presently given to a representative scenario of BmRP investigations and associated engineering analyses, together with an account of the evolutionary process by which the scenarios and the Space Station design requirements they entail are identified. Attention is given to a tether-implemented 'variable gravity centrifuge'.

  13. Graduate Experience in Science Education: The Development of a Science Education Course for Biomedical Science Graduate Students

    Science.gov (United States)

    Markowitz, Dina G.; DuPre, Michael J.

    2007-01-01

    The University of Rochester's Graduate Experience in Science Education (GESE) course familiarizes biomedical science graduate students interested in pursuing academic career tracks with a fundamental understanding of some of the theory, principles, and concepts of science education. This one-semester elective course provides graduate students with…

  14. Publications in biomedical and environmental sciences programs, 1982

    Energy Technology Data Exchange (ETDEWEB)

    Moody, J.B. (comp.)

    1983-04-01

    This bibliography contains 725 references to articles in journals, books, and reports published in the subject area of biomedical and environmental sciences during 1982. There are 553 references to articles published in journals and books and 172 references to reports. The citations appear once ordered by the first author's division or by the performing division. Staff members in the Biomedical and Environmental Sciences divisions have other publications not included in this bibliography; for example, theses, book reviews, abstracts published in journals or symposia proceedings, pending journal publications and reports such as monthly, bimonthly, and quarterly progress reports, contractor reports, and reports for internal distribution. This document is sorted by the division, and then alphabetically by author. The sorting by divisions separates the references by subject area in a simple way. The divisions are represented alphabetically. Indexes are provided by author, title, and journal reference. Reprints of articles referenced in this bibliography can be obtained from the author or the author's division.

  15. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow [Abstract] A study was made of the influence of tahyna virus on the...Suppression of Muscle Macrophage Function in Experimental Tahyna Virus Infection (V. V. Vargin, B. F. Semenov; VOPROSY VIRUSOLOGII, No 2, Mar-Apr 83) 14...Tick-Borne Encephalitis Virus Genome DNA-Copies Into Cellular DNA (I. D. Drynov, et al.; VOPROSY VIRUSOLOGII, No 2, Mar-Apr 83) 32 "Strict

  16. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    Studies) p 116 MARKYAVICHYUS, V. Yu., Institute of Botany , LiSSR Academy of Sciences, Nilnius [Abstract] Three species of mold of the genus Septoria...Jul-Sep 83 (manuscript received 19 Nov 82) pp 15-17 ZVYAGIN, V. N., Scientific Research Institute of Forensic Medicine (director- A. P. Gromov...received 2 Nov 82) pp 29-31 BOYKOVA, N. V., ZARAF’YANTS, G. N., KRAVTSOVA, G. B. and PETRACHKOVA, T. V., Chair of Forensic Medicine, Toxic Chemicals

  17. Cognitive and learning sciences in biomedical and health instructional design: A review with lessons for biomedical informatics education.

    Science.gov (United States)

    Patel, Vimla L; Yoskowitz, Nicole A; Arocha, Jose F; Shortliffe, Edward H

    2009-02-01

    Theoretical and methodological advances in the cognitive and learning sciences can greatly inform curriculum and instruction in biomedicine and also educational programs in biomedical informatics. It does so by addressing issues such as the processes related to comprehension of medical information, clinical problem-solving and decision-making, and the role of technology. This paper reviews these theories and methods from the cognitive and learning sciences and their role in addressing current and future needs in designing curricula, largely using illustrative examples drawn from medical education. The lessons of this past work are also applicable, however, to biomedical and health professional curricula in general, and to biomedical informatics training, in particular. We summarize empirical studies conducted over two decades on the role of memory, knowledge organization and reasoning as well as studies of problem-solving and decision-making in medical areas that inform curricular design. The results of this research contribute to the design of more informed curricula based on empirical findings about how people learn and think, and more specifically, how expertise is developed. Similarly, the study of practice can also help to shape theories of human performance, technology-based learning, and scientific and professional collaboration that extend beyond the domain of medicine. Just as biomedical science has revolutionized health care practice, research in the cognitive and learning sciences provides a scientific foundation for education in biomedicine, the health professions, and biomedical informatics.

  18. Context-Aware Adaptive Hybrid Semantic Relatedness in Biomedical Science

    Science.gov (United States)

    Emadzadeh, Ehsan

    Text mining of biomedical literature and clinical notes is a very active field of research in biomedical science. Semantic analysis is one of the core modules for different Natural Language Processing (NLP) solutions. Methods for calculating semantic relatedness of two concepts can be very useful in solutions solving different problems such as relationship extraction, ontology creation and question / answering [1--6]. Several techniques exist in calculating semantic relatedness of two concepts. These techniques utilize different knowledge sources and corpora. So far, researchers attempted to find the best hybrid method for each domain by combining semantic relatedness techniques and data sources manually. In this work, attempts were made to eliminate the needs for manually combining semantic relatedness methods targeting any new contexts or resources through proposing an automated method, which attempted to find the best combination of semantic relatedness techniques and resources to achieve the best semantic relatedness score in every context. This may help the research community find the best hybrid method for each context considering the available algorithms and resources.

  19. Art and science of authorship for biomedical research publication

    Directory of Open Access Journals (Sweden)

    S S Harsoor

    2016-01-01

    Full Text Available Completion of research is logically followed by process of submission of the outcomes for publication. The objective of this article is to sensitise the young potential authors to improve their skill of writing so that the acceptance rate of publication is improved without significant comments and efforts of the editors of the journal. The article is based on the available literature combined with the experience of the author himself as reviewer and editor of biomedical journals. The treatment patterns of clinicians are moving towards evidence-based medical practice. Hence, a clinically relevant research question based on the contemporary knowledge gap is studied using appropriate research methodology. The writers are informed about the criteria to be fulfilled to claim authorship. Finally, emphasis is laid on the essentials of good medical writing necessary for publication. The writing for submission to biomedical journal is both an art and science in itself. A scientifically well-conducted study along with a sound knowledge of the mechanics of writing will enable the novices to achieve better acceptance rate for publication.

  20. Art and science of authorship for biomedical research publication.

    Science.gov (United States)

    Harsoor, S S

    2016-09-01

    Completion of research is logically followed by process of submission of the outcomes for publication. The objective of this article is to sensitise the young potential authors to improve their skill of writing so that the acceptance rate of publication is improved without significant comments and efforts of the editors of the journal. The article is based on the available literature combined with the experience of the author himself as reviewer and editor of biomedical journals. The treatment patterns of clinicians are moving towards evidence-based medical practice. Hence, a clinically relevant research question based on the contemporary knowledge gap is studied using appropriate research methodology. The writers are informed about the criteria to be fulfilled to claim authorship. Finally, emphasis is laid on the essentials of good medical writing necessary for publication. The writing for submission to biomedical journal is both an art and science in itself. A scientifically well-conducted study along with a sound knowledge of the mechanics of writing will enable the novices to achieve better acceptance rate for publication.

  1. 77 FR 26069 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-05-02

    ... AFFAIRS Joint Biomedical Laboratory Research and Development and Clinical Science Research and Development... following three panels of the Joint Biomedical Laboratory Research and Development and Clinical Science... review by the Board involve a wide range of medical specialties within the general areas of...

  2. 1st International Conference on Computational and Experimental Biomedical Sciences

    CERN Document Server

    Jorge, RM

    2015-01-01

    This book contains the full papers presented at ICCEBS 2013 – the 1st International Conference on Computational and Experimental Biomedical Sciences, which was organized in Azores, in October 2013. The included papers present and discuss new trends in those fields, using several methods and techniques, including active shape models, constitutive models, isogeometric elements, genetic algorithms, level sets, material models, neural networks, optimization, and the finite element method, in order to address more efficiently different and timely applications involving biofluids, computer simulation, computational biomechanics, image based diagnosis, image processing and analysis, image segmentation, image registration, scaffolds, simulation, and surgical planning. The main audience for this book consists of researchers, Ph.D students, and graduate students with multidisciplinary interests related to the areas of artificial intelligence, bioengineering, biology, biomechanics, computational fluid dynamics, comput...

  3. Big biomedical data as the key resource for discovery science.

    Science.gov (United States)

    Toga, Arthur W; Foster, Ian; Kesselman, Carl; Madduri, Ravi; Chard, Kyle; Deutsch, Eric W; Price, Nathan D; Glusman, Gustavo; Heavner, Benjamin D; Dinov, Ivo D; Ames, Joseph; Van Horn, John; Kramer, Roger; Hood, Leroy

    2015-11-01

    Modern biomedical data collection is generating exponentially more data in a multitude of formats. This flood of complex data poses significant opportunities to discover and understand the critical interplay among such diverse domains as genomics, proteomics, metabolomics, and phenomics, including imaging, biometrics, and clinical data. The Big Data for Discovery Science Center is taking an "-ome to home" approach to discover linkages between these disparate data sources by mining existing databases of proteomic and genomic data, brain images, and clinical assessments. In support of this work, the authors developed new technological capabilities that make it easy for researchers to manage, aggregate, manipulate, integrate, and model large amounts of distributed data. Guided by biological domain expertise, the Center's computational resources and software will reveal relationships and patterns, aiding researchers in identifying biomarkers for the most confounding conditions and diseases, such as Parkinson's and Alzheimer's.

  4. Biomedical technology transfer: Applications of NASA science and technology

    Science.gov (United States)

    1976-01-01

    The major efforts of the Stanford Biomedical Applications Team Program at the Stanford University School of Medicine for the period from October 1, 1975 to September 31, 1976 are covered. A completed EMG biotelemetry system which monitors the physiological signals of man and animals in space related research is discussed. The results of a pilot study involving lower body negative pressure testing in cardiac patients has been completed as well as the design and construction of a new leg negative pressure unit for evaluating heart patients. This technology utilizes vacuum chambers to stress the cardiovascular system during space flight. Laboratory tests of an intracranial pressure transducer, have been conducted. Extremely stable long term data using capacative pressure sensors has lead to the order of commercially manufactured monitoring systems base. Projects involving commercialization are: flexible medical electrodes, an echocardioscope, a miniature biotelemetry system, and an on-line ventricular contour detector.

  5. Leading Learning: Science Departments and the Chair

    Science.gov (United States)

    Melville, Wayne; Campbell, Todd; Jones, Doug

    2016-01-01

    In this article, we have considered the role of the chair in leading the learning necessary for a department to become effective in the teaching and learning of science from a reformed perspective. We conceptualize the phrase "leading learning" to mean the chair's constitution of influence, power, and authority to intentionally impact…

  6. Keynote Lecture: The Problems and Challenges in Biomedical Sciences

    OpenAIRE

    Bruce Albert

    2015-01-01

    Distressed by the perverse incentives that have generated the current hyper-competitive biomedical research environment in the United States, four of us published an open-access article in April 2014 entitled: Rescuing US biomedical research from its systemic flaws (Alberts, B., Kirschner, Marc W., Tilghman, Shirley, and  Varmus, H.; Proc. Natl. Acad. Sci. USA 111, 5773-5777 (2014)). As announced in our follow-up piece, Opinion: Addressing systemic problems in the biomedical research enterpri...

  7. The rolling evolution of biomedical science as an essential tool in modern clinical practice.

    Science.gov (United States)

    Blann, Andrew

    2016-01-01

    The British Journal of Biomedical Science is committed to publishing high-quality original research that represents a clear advance in the practice of biomedical science, and reviews that summarise recent advances in the field of biomedical science. The overall aim of the Journal is to provide a platform for the dissemination of new and innovative information on the diagnosis and management of disease that is valuable to the practicing laboratory scientist. The Editorial that follows describes the Journal and provides a perspective of its aims and objectives.

  8. Biomedical Biopolymers, their Origin and Evolution in Biomedical Sciences: A Systematic Review.

    Science.gov (United States)

    Yadav, Preeti; Yadav, Harsh; Shah, Veena Gowri; Shah, Gaurav; Dhaka, Gaurav

    2015-09-01

    Biopolymers provide a plethora of applications in the pharmaceutical and medical applications. A material that can be used for biomedical applications like wound healing, drug delivery and tissue engineering should possess certain properties like biocompatibility, biodegradation to non-toxic products, low antigenicity, high bio-activity, processability to complicated shapes with appropriate porosity, ability to support cell growth and proliferation and appropriate mechanical properties, as well as maintaining mechanical strength. This paper reviews biodegradable biopolymers focusing on their potential in biomedical applications. Biopolymers most commonly used and most abundantly available have been described with focus on the properties relevant to biomedical importance.

  9. A proposal to establish master's in biomedical sciences degree programs in medical school environments.

    Science.gov (United States)

    Ingoglia, Nicholas A

    2009-04-01

    Most graduate schools associated with medical schools offer programs leading to the PhD degree but pay little attention to master's programs. This is unfortunate because many university graduates who are interested specifically in biomedical rather than pure science fields need further education before making decisions on whether to enter clinical, research, education, or business careers. Training for these students is done best in a medical school, rather than a graduate university, environment and by faculty who are engaged in research in the biomedical sciences. Students benefit from these programs by exploring career options they might not have previously considered while learning about disease-related subjects at the graduate level. Graduate faculty can also benefit by being compensated for their teaching with a portion of the tuition revenue, funds that can help run their laboratories and support other academic expenses. Faculty also may attract talented students to their labs and to their PhD programs by exposing them to a passion for research. The graduate school also benefits by collecting masters tuition revenue that can be used toward supporting PhD stipends. Six-year outcome data from the program at Newark show that, on completion of the program, most students enter educational, clinical, or research careers and that the graduate school has established a new and significant stream of revenue. Thus, the establishment of a master's program in biomedical sciences that helps students match their academic abilities with their career goals significantly benefits students as well as the graduate school and its faculty.

  10. The Recognition of Biomedical Engineering Within the International Council for Science

    Science.gov (United States)

    2001-10-25

    Forty years separate the emergence of Biomedical Engineering in a meeting in Paris at UNESCO in 1959 from its recognition together with Medical...Physics in 1999 by the International Council for Science. The main problems of definition and of identity of Biomedical Engineering as a scientific

  11. Mining biomedical images towards valuable information retrieval in biomedical and life sciences.

    Science.gov (United States)

    Ahmed, Zeeshan; Zeeshan, Saman; Dandekar, Thomas

    2016-01-01

    Biomedical images are helpful sources for the scientists and practitioners in drawing significant hypotheses, exemplifying approaches and describing experimental results in published biomedical literature. In last decades, there has been an enormous increase in the amount of heterogeneous biomedical image production and publication, which results in a need for bioimaging platforms for feature extraction and analysis of text and content in biomedical images to take advantage in implementing effective information retrieval systems. In this review, we summarize technologies related to data mining of figures. We describe and compare the potential of different approaches in terms of their developmental aspects, used methodologies, produced results, achieved accuracies and limitations. Our comparative conclusions include current challenges for bioimaging software with selective image mining, embedded text extraction and processing of complex natural language queries.

  12. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs.

    Science.gov (United States)

    Bernstam, Elmer V; Hersh, William R; Johnson, Stephen B; Chute, Christopher G; Nguyen, Hien; Sim, Ida; Nahm, Meredith; Weiner, Mark G; Miller, Perry; DiLaura, Robert P; Overcash, Marc; Lehmann, Harold P; Eichmann, David; Athey, Brian D; Scheuermann, Richard H; Anderson, Nick; Starren, Justin; Harris, Paul A; Smith, Jack W; Barbour, Ed; Silverstein, Jonathan C; Krusch, David A; Nagarajan, Rakesh; Becich, Michael J

    2009-07-01

    Clinical and translational research increasingly requires computation. Projects may involve multiple computationally oriented groups including information technology (IT) professionals, computer scientists, and biomedical informaticians. However, many biomedical researchers are not aware of the distinctions among these complementary groups, leading to confusion, delays, and suboptimal results. Although written from the perspective of Clinical and Translational Science Award (CTSA) programs within academic medical centers, this article addresses issues that extend beyond clinical and translational research. The authors describe the complementary but distinct roles of operational IT, research IT, computer science, and biomedical informatics using a clinical data warehouse as a running example. In general, IT professionals focus on technology. The authors distinguish between two types of IT groups within academic medical centers: central or administrative IT (supporting the administrative computing needs of large organizations) and research IT (supporting the computing needs of researchers). Computer scientists focus on general issues of computation such as designing faster computers or more efficient algorithms, rather than specific applications. In contrast, informaticians are concerned with data, information, and knowledge. Biomedical informaticians draw on a variety of tools, including but not limited to computers, to solve information problems in health care and biomedicine. The paper concludes with recommendations regarding administrative structures that can help to maximize the benefit of computation to biomedical research within academic health centers.

  13. British Journal of Biomedical Science in 2015: what have we learned?

    Science.gov (United States)

    Blann, Andrew; Nation, Brian

    2016-01-01

    In 2015, the British Journal of Biomedical Science published 47 reports on topics relating to the various disciplines within biomedical science. Of these, the majority were in infection science (15 in microbiology and two in virology) and blood science (seven in biochemistry, four in haematology, three in immunology and one in transplantation), with a smaller number in cellular sciences (four reports) and with one review across disciplines. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

  14. Interactive Processing and Visualization of Image Data forBiomedical and Life Science Applications

    Energy Technology Data Exchange (ETDEWEB)

    Staadt, Oliver G.; Natarjan, Vijay; Weber, Gunther H.; Wiley,David F.; Hamann, Bernd

    2007-02-01

    Background: Applications in biomedical science and life science produce large data sets using increasingly powerful imaging devices and computer simulations. It is becoming increasingly difficult for scientists to explore and analyze these data using traditional tools. Interactive data processing and visualization tools can support scientists to overcome these limitations. Results: We show that new data processing tools and visualization systems can be used successfully in biomedical and life science applications. We present an adaptive high-resolution display system suitable for biomedical image data, algorithms for analyzing and visualization protein surfaces and retinal optical coherence tomography data, and visualization tools for 3D gene expression data. Conclusion: We demonstrated that interactive processing and visualization methods and systems can support scientists in a variety of biomedical and life science application areas concerned with massive data analysis.

  15. New frontiers in biomedical science and engineering during 2014-2015.

    Science.gov (United States)

    Liu, Feng; Lee, Dong-Hoon; Lagoa, Ricardo; Kumar, Sandeep

    2015-01-01

    The International Conference on Biomedical Engineering and Biotechnology (ICBEB) is an international meeting held once a year. This, the fourth International Conference on Biomedical Engineering and Biotechnology (ICBEB2015), will be held in Shanghai, China, during August 18th-21st, 2015. This annual conference intends to provide an opportunity for researchers and practitioners at home and abroad to present the most recent frontiers and future challenges in the fields of biomedical science, biomedical engineering, biomaterials, bioinformatics and computational biology, biomedical imaging and signal processing, biomechanical engineering and biotechnology, etc. The papers published in this issue are selected from this Conference, which witness the advances in biomedical engineering and biotechnology during 2014-2015.

  16. From Bench to Bedside: A Communal Utility Value Intervention to Enhance Students' Biomedical Science Motivation

    Science.gov (United States)

    Brown, Elizabeth R.; Smith, Jessi L.; Thoman, Dustin B.; Allen, Jill M.; Muragishi, Gregg

    2015-01-01

    Motivating students to pursue science careers is a top priority among many science educators. We add to the growing literature by examining the impact of a utility value intervention to enhance student's perceptions that biomedical science affords important utility work values. Using an expectancy-value perspective, we identified and tested 2…

  17. Biomedical scientist training officers' evaluation of integrated (co-terminus) Applied Biomedical Science BSc programmes: a multicentre study.

    Science.gov (United States)

    Pitt, S J; Cunningham, J M

    2011-01-01

    The introduction of the Institute of Biomedical Science (IBMS) portfolio for pre-registration training in 2003 allowed universities to develop integrated (co-terminus) biomedical science BSc programmes. Students undertake structured placements within clinical pathology laboratories as part of their degree. The clinical training and professional development of students is undertaken by training officers (TOs), who are experienced Health Professions Council (HPC)-registered biomedical scientists and usually also members of the IBMS. This study aims to evaluate TOs' perceptions of these integrated degrees as a means of delivering pre-registration training for biomedical scientists. A questionnaire to collect quantitative data and be completed anonymously was sent to TOs, via staff at participating universities. Items considered TOs' perceptions in four categories: how well students fitted into the laboratory team, their professional and scientific development, the impact of delivering integrated degrees on service delivery, and the commitment to training students. Surveys took place in 2007, 2008 and 2009 and involved TOs taking students from 10, 14 and 17 universities each year, respectively. The response rates to the survey were 60% in 2007, 34% in 2008 and 12% in 2009. Participants were representative in terms of age, gender and pathology discipline and had a broad range of experience with students. The overall mean score for TOs perceptions was 3.38 in 2007 which increased significantly to 3.99 in 2009 (Kruskall Wallis test chi2 = 21.13, P<0.01). Mean scores in three of the four categories were positive in 2007, although the impact on service delivery was perceived negatively. In all areas, means were significantly greater in 2009. The results indicate that TOs view the integrated degrees favourably and are happy with the scientific and professional development of students. Although designing training sessions suitable for undergraduates took extra work initially

  18. The Role Biomedical Science Laboratories Can Play in Improving Science Knowledge and Promoting First-Year Nursing Academic Success

    Science.gov (United States)

    Arneson, Pam

    2011-01-01

    The need for additional nursing and health care professionals is expected to increase dramatically over the next 20 years. With this in mind, students must have strong biomedical science knowledge to be competent in their field. Some studies have shown that participation in bioscience laboratories can enhance science knowledge. If this is true, an…

  19. Should MD-PhD programs encourage graduate training in disciplines beyond conventional biomedical or clinical sciences?

    Science.gov (United States)

    O'Mara, Ryan J; Hsu, Stephen I; Wilson, Daniel R

    2015-02-01

    The goal of MD-PhD training programs is to produce physician-scientists with unique capacities to lead the future biomedical research workforce. The current dearth of physician-scientists with expertise outside conventional biomedical or clinical sciences raises the question of whether MD-PhD training programs should allow or even encourage scholars to pursue doctoral studies in disciplines that are deemed nontraditional, yet are intrinsically germane to major influences on health. This question is especially relevant because the central value and ultimate goal of the academic medicine community is to help attain the highest level of health and health equity for all people. Advances in medical science and practice, along with improvements in health care access and delivery, are steps toward health equity, but alone they will not come close to eliminating health inequalities. Addressing the complex health issues in our communities and society as a whole requires a biomedical research workforce with knowledge, practice, and research skills well beyond conventional biomedical or clinical sciences. To make real progress in advancing health equity, educational pathways must prepare physician-scientists to treat both micro and macro determinants of health. The authors argue that MD-PhD programs should allow and encourage their scholars to cross boundaries into less traditional disciplines such as epidemiology, statistics, anthropology, sociology, ethics, public policy, management, economics, education, social work, informatics, communications, and marketing. To fulfill current and coming health care needs, nontraditional MD-PhD students should be welcomed and supported as valuable members of our biomedical research workforce.

  20. The Faculty Costs to Educate a Biomedical Sciences Graduate Student

    Science.gov (United States)

    Smolka, Adam J.; Halushka, Perry V.; Garrett-Mayer, Elizabeth

    2015-01-01

    Academic medical centers nationwide face numerous fiscal challenges resulting from implementation of restructured healthcare delivery models, contracting state support for higher education, and increased competition for federal and other sources of biomedical research funding. In pursuing greater accountability and transparency in its fiscal…

  1. Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences

    Science.gov (United States)

    Ossorio, Pilar; Duster, Troy

    2005-01-01

    Among biomedical scientists, there is a great deal of controversy over the nature of race, the relevance of racial categories for research, and the proper methods of using racial variables. This article argues that researchers and scholars should avoid a binary-type argument, in which the question is whether to use race always or never.…

  2. Contribution of Electrochemistry to the Biomedical and Pharmaceutical Analytical Sciences.

    Science.gov (United States)

    Kauffmann, Jean-Michel; Patris, Stephanie; Vandeput, Marie; Sarakbi, Ahmad; Sakira, Abdul Karim

    2016-01-01

    All analytical techniques have experienced major progress since the last ten years and electroanalysis is also involved in this trend. The unique characteristics of phenomena occurring at the electrode-solution interface along with the variety of electrochemical methods currently available allow for a broad spectrum of applications. Potentiometric, conductometric, voltammetric and amperometric methods are briefly reviewed with a critical view in terms of performance of the developed instrumentation with special emphasis on pharmaceutical and biomedical applications.

  3. Keynote Lecture: The Problems and Challenges in Biomedical Sciences

    Directory of Open Access Journals (Sweden)

    Bruce Albert

    2015-08-01

    Full Text Available Distressed by the perverse incentives that have generated the current hyper-competitive biomedical research environment in the United States, four of us published an open-access article in April 2014 entitled: Rescuing US biomedical research from its systemic flaws (Alberts, B., Kirschner, Marc W., Tilghman, Shirley, and  Varmus, H.; Proc. Natl. Acad. Sci. USA 111, 5773-5777 (2014. As announced in our follow-up piece, Opinion: Addressing systemic problems in the biomedical research enterprise (Proc. Natl. Acad. Sci. USA 112, 1912-1913 (2015, we have formed a 16-member steering committee to oversee a new website that is designed to collect suggestions for actions that can ameliorate the identified problems, as well as to highlight promising changes that are either underway or proposed (see http://rescuingbiomedicalresearch.org.  Despite widespread agreement concerning the problems, any substantial change in the system is bound to be controversial. Experiments are therefore needed. In my talk, I will outline some possible ideas for overcoming the inertia that prevents moving forward.We are encouraging both national and international contributions to this effort, since the problems that we have described are by no means unique to the United States.

  4. Using Biomedically Relevant Multimedia Content in an Introductory Physics Course for Life Science and Pre-health Students

    Science.gov (United States)

    Mylott, Elliot; Kutschera, Ellynne; Dunlap, Justin C.; Christensen, Warren; Widenhorn, Ralf

    2016-04-01

    We will describe a one-quarter pilot algebra-based introductory physics course for pre-health and life science majors. The course features videos with biomedical experts and cogent biomedically inspired physics content. The materials were used in a flipped classroom as well as an all-online environment where students interacted with multimedia materials online and prior to engaging in classroom activities. Pre-lecture questions on both the medical content covered in the video media and the physics concepts in the written material were designed to engage students and probe their understanding of physics. The course featured group discussion and peer-lead instruction. Following in-class instruction, students engaged with homework assignments which explore the connections of physics and the medical field in a quantitative manner. Course surveys showed a positive response by the vast majority of students. Students largely indicated that the course helped them to make a connection between physics and the biomedical field. The biomedical focus and different course format were seen as an improvement to previous traditional physics instruction.

  5. Biomedical technical transfer. Applications of NASA science and technology

    Science.gov (United States)

    1976-01-01

    Lower body negative pressure testing in cardiac patients has been completed as well as the design and construction of a new leg negative unit for evaluating heart patients. This technology is based on NASA research, using vacuum chambers to stress the cardiovascular system during space flight. Additional laboratory tests of an intracranial pressure transducer, have been conducted. Three new biomedical problems to which NASA technology is applicable are also identified. These are: a communication device for the speech impaired, the NASA development liquid-cooled garment, and miniature force transducers for heart research.

  6. Polymers in life sciences: Pharmaceutical and biomedical applications

    Science.gov (United States)

    Barba, Anna Angela; Dalmoro, Annalisa; d'Amore, Matteo; Lamberti, Gaetano; Cascone, Sara; Titomanlio, Giuseppe

    2015-12-01

    This paper deals with the work done by prof. Titomanlio and his group in the fields of pharmaceutical and biomedical applications of polymers. In particular, the main topics covered are: i) controlled drug release from pharmaceuticals based on hydrogel for oral delivery of drugs; ii) production and characterization of micro and nanoparticles based on stimuli-responsive polymers; iii) use of polymers for coronary stent gel-paving; iv) design and realization of novel methods (in-vitro and in-silico) to test polymer-based pharmaceuticals.

  7. Establishment of an index system for evaluating outstanding biomedical scientists for science foundation of Shanghai

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yu-jing; CHEN Xin; REN Xu-feng

    2007-01-01

    Objective:To establish a scientific, objective and applicable index system for evaluating outstanding biomedical scientists for science foundation of Shanghai. Methods: According to the principal indices that have been used in the developed countries for evaluating their talented personnel and the reality of our country, an index system was set up to evaluate the outstanding biomedical scientists for Shanghai science foundation. The following parameters were used to simplify the indices: correlation coefficient,multiple correlation coefficient, partial correlation coefficient, creditability, and discriminatory power.And analytic hierarchy process was used to determine the weights of each index. Results and Conclusions:The established index system is scientific and applicable; it is helpful for cultivating and evaluating outstanding biomedical scientists.

  8. A New Voice in Science : Patient participation in decision-making on biomedical research

    NARCIS (Netherlands)

    Caron-Flinterman, J.F.

    2005-01-01

    End-users are increasingly involved in decision-making concerning science and technology. This dissertation focuses on a specific kind of end-user participation: patient participation in decision-making on bio-medical research. Since patients can be considered relevant experts and stakeholders with

  9. Biomedical and environmental sciences programs at the Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Richmond, C.R.; Johnson, C.A.

    1988-02-01

    This progress report summarizes the research and development activities conducted in the Biomedical and Environmental Sciences Programs of Oak Ridge National Laboratory. The report is structured to provide descriptions of current activities and accomplishments in each of the major organizational units. Following the accounts of research programs, is a list of publications and awards to its members. 6 figs., 14 tabs.

  10. Impact of the USMLE Step 1 on Teaching and Learning of the Basic Biomedical Sciences.

    Science.gov (United States)

    Swanson, David B.; And Others

    1992-01-01

    Discussion of the newly modified United States Medical Licensing Examination Step 1 reviews the test, phase-in plans, and potential impact on basic biomedical sciences education. It is recommended that medical schools not use the test as the sole criterion for promotion to the third year and carefully review other examination-related requirements…

  11. Drug design and discovery: translational biomedical science varies among countries.

    Science.gov (United States)

    Weaver, Ian N; Weaver, Donald F

    2013-10-01

    Drug design and discovery is an innovation process that translates the outcomes of fundamental biomedical research into therapeutics that are ultimately made available to people with medical disorders in many countries throughout the world. To identify which nations succeed, exceed, or fail at the drug design/discovery endeavor--more specifically, which countries, within the context of their national size and wealth, are "pulling their weight" when it comes to developing medications targeting the myriad of diseases that afflict humankind--we compiled and analyzed a comprehensive survey of all new drugs (small molecular entities and biologics) approved annually throughout the world over the 20-year period from 1991 to 2010. Based upon this analysis, we have devised prediction algorithms to ascertain which countries are successful (or not) in contributing to the worldwide need for effective new therapeutics.

  12. Graduate Experience in Science Education: the development of a science education course for biomedical science graduate students.

    Science.gov (United States)

    Markowitz, Dina G; DuPré, Michael J

    2007-01-01

    The University of Rochester's Graduate Experience in Science Education (GESE) course familiarizes biomedical science graduate students interested in pursuing academic career tracks with a fundamental understanding of some of the theory, principles, and concepts of science education. This one-semester elective course provides graduate students with practical teaching and communication skills to help them better relate science content to, and increase their confidence in, their own teaching abilities. The 2-h weekly sessions include an introduction to cognitive hierarchies, learning styles, and multiple intelligences; modeling and coaching some practical aspects of science education pedagogy; lesson-planning skills; an introduction to instructional methods such as case studies and problem-based learning; and use of computer-based instructional technologies. It is hoped that the early development of knowledge and skills about teaching and learning will encourage graduate students to continue their growth as educators throughout their careers. This article summarizes the GESE course and presents evidence on the effectiveness of this course in providing graduate students with information about teaching and learning that they will use throughout their careers.

  13. Inclusion of policies on ethical standards in animal experiments in biomedical science journals.

    Science.gov (United States)

    Rands, Sean A

    2011-11-01

    Most published biomedical research involving animal models is evaluated carefully to ensure that appropriate ethical standards are met. In the current study, 500 journals randomly selected from MedLine were assessed for whether they presented animal research. Of the 138 journals that did, the instructions to authors of 85 (61.6%) included a requirement for author assurance of adherence to ethical standards during experiments involving animals. In comparison to a wider range of biologic journals, biomedical science journals were more likely to have some sort of ethical policy concerning the reporting and presentation of animal experiments.

  14. Biomedical Science, Unit II: Nutrition in Health and Medicine. Digestion of Foods; Organic Chemistry of Nutrients; Energy and Cell Respiration; The Optimal Diet; Foodborne Diseases; Food Technology; Dental Science and Nutrition. Student Text. Revised Version, 1975.

    Science.gov (United States)

    Biomedical Interdisciplinary Curriculum Project, Berkeley, CA.

    This student text presents instructional materials for a unit of science within the Biomedical Interdisciplinary Curriculum Project (BICP), a two-year interdisciplinary precollege curriculum aimed at preparing high school students for entry into college and vocational programs leading to a career in the health field. Lessons concentrate on…

  15. International Conference for Innovation in Biomedical Engineering and Life Sciences

    CERN Document Server

    Usman, Juliana; Mohktar, Mas; Ahmad, Mohd

    2016-01-01

    This volumes presents the proceedings of ICIBEL 2015, organized by the Centre for Innovation in Medical Engineering (CIME) under Innovative Technology Research Cluster, University of Malaya. It was held in Kuala Lumpur, Malaysia, from 6-8 December 2015. The ICIBEL 2015 conference promotes the latest researches and developments related to the integration of the Engineering technology in medical fields and life sciences. This includes the latest innovations, research trends and concerns, challenges and adopted solution in the field of medical engineering and life sciences. .

  16. Reaching Consensus on Essential Biomedical Science Learning Objectives in a Dental Curriculum.

    Science.gov (United States)

    Best, Leandra; Walton, Joanne N; Walker, Judith; von Bergmann, HsingChi

    2016-04-01

    This article describes how the University of British Columbia Faculty of Dentistry reached consensus on essential basic biomedical science objectives for DMD students and applied the information to the renewal of its DMD curriculum. The Delphi Method was used to build consensus among dental faculty members and students regarding the relevance of over 1,500 existing biomedical science objectives. Volunteer panels of at least three faculty members (a basic scientist, a general dentist, and a dental specialist) and a fourth-year dental student were formed for each of 13 biomedical courses in the first two years of the program. Panel members worked independently and anonymously, rating each course objective as "need to know," "nice to know," "irrelevant," or "don't know." Panel members were advised after each round which objectives had not yet achieved a 75% consensus and were asked to reconsider their ratings. After a maximum of three rounds to reach consensus, a second group of faculty experts reviewed and refined the results to establish the biomedical science objectives for the renewed curriculum. There was consensus on 46% of the learning objectives after round one, 80% after round two, and 95% after round three. The second expert group addressed any remaining objectives as part of its review process. Only 47% of previous biomedical science course objectives were judged to be essential or "need to know" for the general dentist. The consensus reached by participants in the Delphi Method panels and a second group of faculty experts led to a streamlined, better integrated DMD curriculum to prepare graduates for future practice.

  17. Applying Nanotechnology to Human Health: Revolution in Biomedical Sciences

    Directory of Open Access Journals (Sweden)

    Siddhartha Shrivastava

    2009-01-01

    Full Text Available Recent research on biosystems at the nanoscale has created one of the most dynamic science and technology domains at the confluence of physical sciences, molecular engineering, biology, biotechnology, and medicine. This domain includes better understanding of living and thinking systems, revolutionary biotechnology processes, synthesis of new drugs and their targeted delivery, regenerative medicine, neuromorphic engineering, and developing a sustainable environment. Nanobiosystems research is a priority in many countries and its relevance within nanotechnology is expected to increase in the future. The realisation that the nanoscale has certain properties needed to solve important medical challenges and cater to unmet medical needs is driving nanomedical research. The present review explores the significance of nanoscience and latest nanotechnologies for human health. Addressing the associated opportunities, the review also suggests how to manage far-reaching developments in these areas.

  18. The placebo puzzle: examining the discordant space between biomedical science and illness/healing.

    Science.gov (United States)

    Pohlman, Shawn; Cibulka, Nancy J; Palmer, Janice L; Lorenz, Rebecca A; SmithBattle, Lee

    2013-03-01

    The placebo response presents an enigma to biomedical science: how can 'inert' or 'sham' procedures reduce symptoms and produce physiological changes that are comparable to prescribed treatments? In this study, we examine this puzzle by explicating the discordant space between the prevailing biomedical paradigm, which focuses on a technical understanding of diagnosis and treatment, and a broader understanding of illness and healing as relational and embodied. Although biomedical achievements are impressive, the knowledge resulting from this paradigm is limited by its ontological and epistemological assumptions. When the body and world are objectified, illness meanings, therapeutic relationships, and healing practices are dismissed or distorted. In spite of a robust critique of the tenets of biomedicine for guiding practice, the biomedical paradigm retains a tenacious hold on evidence-based medicine and nursing, downplaying our clinical understanding of the sentient body, patients' life-worlds, and illness and healing. In reality, skilled nurses rely on multiple forms of knowledge in providing high-quality care to particular patients. Clinically wise nurses integrate their experience and knowledge of patients' priorities, fears, and illness trajectories along with biomedical findings to make astute judgments and promote health and healing.

  19. A new paradigm for graduate research and training in the biomedical sciences and engineering.

    Science.gov (United States)

    Humphrey, J D; Coté, G L; Walton, J R; Meininger, G A; Laine, G A

    2005-06-01

    98Emphasis on the individual investigator has fostered discovery for centuries, yet it is now recognized that the complexity of problems in the biomedical sciences and engineering requires collaborative efforts from individuals having diverse training and expertise. Various approaches can facilitate interdisciplinary interactions, but we submit that there is a critical need for a new educational paradigm for the way that we train biomedical engineers, life scientists, and mathematicians. We cannot continue to train graduate students in isolation within single disciplines, nor can we ask any one individual to learn all the essentials of biology, engineering, and mathematics. We must transform how students are trained and incorporate how real-world research and development are done-in diverse, interdisciplinary teams. Our fundamental vision is to create an innovative paradigm for graduate research and training that yields a new generation of biomedical engineers, life scientists, and mathematicians that is more diverse and that embraces and actively pursues a truly interdisciplinary, team-based approach to research based on a known benefit and mutual respect. In this paper, we describe our attempt to accomplish this via focused training in biomechanics, biomedical optics, mathematics, mechanobiology, and physiology. The overall approach is applicable, however, to most areas of biomedical research.

  20. Truth in basic biomedical science will set future mankind free.

    Science.gov (United States)

    Ling, Gilbert N

    2011-01-01

    It is self-evident that continued wellbeing and prosperity of our species in time to come depends upon a steady supply of major scientific and technologic innovations. However, major scientific and technical innovations are rare. As a rule, they grow only in the exceptionally fertile minds of men and women, who have fully mastered the underlying basic sciences. To waken their interest in science at an early critical age and to nurture and enhance that interest afterward, good textbooks at all level of education that accurately portray the relevant up-to-date knowledge are vital. As of now, the field of science that offers by far the greatest promise for the future of humanity is the science of life at the most basic cell and below-cell level. Unfortunately, it is precisely this crucial part of the (standardized) biological textbooks for all high schools and colleges in the US and abroad that have become, so to speak, fossilized. As a result, generation after generation of (educated) young men and women have been and are still being force-fed as established scientific truth an obsolete membrane (pump) theory, which has been categorically disproved half a century ago (see Endnote 1.) To reveal this Trojan horse of a theory for what it really is demands the concerted efforts of many courageous individuals especially young biology teachers who take themselves and their career seriously. But even the most courageous and the most resourceful won't find the task easy. To begin with, they would find it hard to access the critical scientific knowledge, with which to convert the skeptic and to rally the friendly. For the wealth of mutually supportive evidence against the membrane (pump) theory are often hidden in inaccessible publications and/or in languages other than English. To overcome this seemingly trivial but in fact formidable obstacle and to reveal the beauty and coherence of the existing but untaught truth, I put together in this small package a collection of the

  1. 77 FR 5247 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2012-02-02

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION..., ``Second External Review Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075B). The document... lead (Pb). EPA is releasing this draft document to seek review by the Clean Air Scientific...

  2. 77 FR 70776 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2012-11-27

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION..., ``Third External Review Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075C). The document... lead (Pb). EPA is releasing this draft document to seek review by the Clean Air Scientific...

  3. 76 FR 38650 - Draft Integrated Science Assessment for Lead

    Science.gov (United States)

    2011-07-01

    ... AGENCY Draft Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency. ACTION... Draft Integrated Science Assessment for Lead'' (EPA/600/R-10/075A). The original Federal Register notice... Development as part of the review of the National Ambient Air Quality Standards (NAAQS) for Lead. DATES:...

  4. 78 FR 38318 - Integrated Science Assessment for Lead

    Science.gov (United States)

    2013-06-26

    ... AGENCY Integrated Science Assessment for Lead AGENCY: Environmental Protection Agency (EPA). ACTION..., ``Integrated Science Assessment for Lead'' (EPA/600/R-10/075F). The document was prepared by the National... review of the national ambient air quality standards (NAAQS) for lead (Pb). DATES: The document will...

  5. Using Biomedically Relevant Multimedia Content in an Introductory Physics Course for Life Science and Pre-Health Students

    Science.gov (United States)

    Mylott, Elliot; Kutschera, Ellynne; Dunlap, Justin C.; Christensen, Warren; Widenhorn, Ralf

    2016-01-01

    We will describe a one-quarter pilot algebra-based introductory physics course for pre-health and life science majors. The course features videos with biomedical experts and cogent biomedically inspired physics content. The materials were used in a flipped classroom as well as an all-online environment where students interacted with multimedia…

  6. Tutorials for large classes of Common Foundation Program biomedical science students: successes and challenges.

    Science.gov (United States)

    al-Modhefer, Abdul-Kadhum J A; Roe, Sean M

    2010-05-01

    The aim of this paper is to investigate the problems encountered conducting biomedical science tutorials for nursing students in large classes with a typical student: staff ratio of 45:1. The study is based on level 1 Common Foundation Program students from the School of Nursing and Midwifery, Queen's University Belfast at the conclusion of two phases of biomedical sciences education which include a course of 12 interactive tutorials. Survey and interview methodologies were employed to investigate difficulties encountered by students in these large tutorial classes, to ascertain what characterises a good tutor and to explore student attitudes to interactive learning. The barriers to effective teaching and learning in tutorials are discussed and subsequently, a set of guidelines is proposed to enhance learning in them. These include being aware of the ability of the student group, having a compassionate questioning style, tailoring the teaching environment to fit the aims of the class and experimenting with different tutorial formats.

  7. Integrating Contemplative Tools into Biomedical Science Education and Research Training Programs

    Directory of Open Access Journals (Sweden)

    Rodney R. Dietert

    2014-01-01

    Full Text Available Academic preparation of science researchers and/or human or veterinary medicine clinicians through the science, technology, engineering, and mathematics (STEM curriculum has usually focused on the students (1 acquiring increased disciplinary expertise, (2 learning needed methodologies and protocols, and (3 expanding their capacity for intense, persistent focus. Such educational training is effective until roadblocks or problems arise via this highly-learned approach. Then, the health science trainee may have few tools available for effective problem solving. Training to achieve flexibility, adaptability, and broadened perspectives using contemplative practices has been rare among biomedical education programs. To address this gap, a Cornell University-based program involving formal biomedical science coursework, and health science workshops has been developed to offer science students, researchers and health professionals a broader array of personal, contemplation-based, problem-solving tools. This STEM educational initiative includes first-person exercises designed to broaden perceptional awareness, decrease emotional drama, and mobilize whole-body strategies for creative problem solving. Self-calibration and journaling are used for students to evaluate the personal utility of each exercise. The educational goals are to increase student self-awareness and self-regulation and to provide trainees with value-added tools for career-long problem solving. Basic elements of this educational initiative are discussed using the framework of the Tree of Contemplative Practices.

  8. Modern Trends in Imaging XI: Impedance Measurements in the Biomedical Sciences

    Directory of Open Access Journals (Sweden)

    Frederick D. Coffman

    2012-01-01

    Full Text Available Biological organisms and their component organs, tissues and cells have unique electrical impedance properties. Impedance properties often change with changes in structure, composition, and metabolism, and can be indicative of the onset and progression of disease states. Over the past 100 years, instruments and analytical methods have been developed to measure the impedance properties of biological specimens and to utilize these measurements in both clinical and basic science settings. This chapter will review the applications of impedance measurements in the biomedical sciences, from whole body analysis to impedance measurements of single cells and cell monolayers, and how cellular impedance measuring instruments can now be used in high throughput screening applications.

  9. Resident's morning report: an opportunity to reinforce principles of biomedical science in a clinical context.

    Science.gov (United States)

    Brass, Eric P

    2013-01-01

    The principles of biochemistry are core to understanding cellular and tissue function, as well as the pathophysiology of disease. However, the clinical utility of biochemical principles is often obscure to clinical trainees. Resident's Morning Report is a common teaching conference in which residents present clinical cases of interest to a faculty member for discussion. This venue provides an opportunity to illustrate how basic biomedical principles facilitate an understanding of the clinical presentation, the relevant pathophysiology, and the rationale for diagnostic and therapeutic strategies. A discussion of biochemical principles can easily be incorporated into these case discussions, with the potential to reinforce these concepts and to illustrate their application to clinical decision making. This approach maintains the effort to teach basic biomedical sciences in the context of clinical application across the educational continuum.

  10. Clinical and basic science teachers' opinions about the required depth of biomedical knowledge for medical students.

    Science.gov (United States)

    Koens, Franciska; Custers, Eugène J F M; ten Cate, Olle T J

    2006-05-01

    The aim of the present study was to investigate whether basic scientists and physicians agree on the required depth of biomedical knowledge of medical students at graduation. A selection of basic science and clinical teachers rated the relevance of biomedical topics for students at graduation, illustrated by 80 example items. The items were derived from ten organ systems and designed at four levels: clinical, organ, cellular and molecular. Respondents were asked to identify for each item to what extent recently graduated medical students should have knowledge about it. In addition, they were asked to indicate whether the content of the item should be included in the medical curriculum. Analysis showed that basic scientists and physicians do not diverge at the clinical level. At the organ, cellular and molecular levels however, basic scientists judge that medical students should have more active knowledge. As expected, basic scientists also indicate that more deep level content should be included. Explanations for this phenomenon will be discussed.

  11. Discovery informatics in biological and biomedical sciences: research challenges and opportunities.

    Science.gov (United States)

    Honavar, Vasant

    2015-01-01

    New discoveries in biological, biomedical and health sciences are increasingly being driven by our ability to acquire, share, integrate and analyze, and construct and simulate predictive models of biological systems. While much attention has focused on automating routine aspects of management and analysis of "big data", realizing the full potential of "big data" to accelerate discovery calls for automating many other aspects of the scientific process that have so far largely resisted automation: identifying gaps in the current state of knowledge; generating and prioritizing questions; designing studies; designing, prioritizing, planning, and executing experiments; interpreting results; forming hypotheses; drawing conclusions; replicating studies; validating claims; documenting studies; communicating results; reviewing results; and integrating results into the larger body of knowledge in a discipline. Against this background, the PSB workshop on Discovery Informatics in Biological and Biomedical Sciences explores the opportunities and challenges of automating discovery or assisting humans in discovery through advances (i) Understanding, formalization, and information processing accounts of, the entire scientific process; (ii) Design, development, and evaluation of the computational artifacts (representations, processes) that embody such understanding; and (iii) Application of the resulting artifacts and systems to advance science (by augmenting individual or collective human efforts, or by fully automating science).

  12. Measuring revolutionary biomedical science 1992-2006 using Nobel prizes, Lasker (clinical medicine) awards and Gairdner awards (NLG metric).

    Science.gov (United States)

    Charlton, Bruce G

    2007-01-01

    The Nobel prize for medicine or physiology, the Lasker award for clinical medicine, and the Gairdner international award are given to individuals for their role in developing theories, technologies and discoveries which have changed the direction of biomedical science. These distinctions have been used to develop an NLG metric to measure research performance and trends in 'revolutionary' biomedical science with the aim of identifying the premier revolutionary science research institutions and nations from 1992-2006. I have previously argued that the number of Nobel laureates in the biomedical field should be expanded to about nine per year and the NLG metric attempts to predict the possible results of such an expansion. One hundred and nineteen NLG prizes and awards were made during the past fifteen years (about eight per year) when overlapping awards had been removed. Eighty-five were won by the USA, revealing a massive domination in revolutionary biomedical science by this nation; the UK was second with sixteen awards; Canada had five, Australia four and Germany three. The USA had twelve elite centres of revolutionary biomedical science, with University of Washington at Seattle and MIT in first position with six awards and prizes each; Rockefeller University and Caltech were jointly second placed with five. Surprisingly, Harvard University--which many people rank as the premier world research centre--failed to reach the threshold of three prizes and awards, and was not included in the elite list. The University of Oxford, UK, was the only institution outside of the USA which featured as a significant centre of revolutionary biomedical science. Long-term success at the highest level of revolutionary biomedical science (and probably other sciences) probably requires a sufficiently large number of individually-successful large institutions in open competition with one another--as in the USA. If this model cannot be replicated within smaller nations, then it implies

  13. Teaching authorship and publication practices in the biomedical and life sciences.

    Science.gov (United States)

    Macrina, Francis L

    2011-06-01

    Examination of a limited number of publisher's Instructions for Authors, guidelines from two scientific societies, and the widely accepted policy document of the International Committee of Medical Journal Editors (ICMJE) provided useful information on authorship practices. Three of five journals examined (Nature, Science, and the Proceedings of the National Academy of Sciences) publish papers across a variety of disciplines. One is broadly focused on topics in medical research (New England Journal of Medicine) and one publishes research reports in a single discipline (Journal of Bacteriology). Similar elements of publication policy and accepted practices were found across the policies of these journals articulated in their Instructions for Authors. A number of these same elements were found in the professional society guidelines of the Society for Neuroscience and the American Chemical Society, as well as the ICMJE Uniform Requirements for Manuscripts Submitted to Biomedical Journals. Taken together, these sources provide the basis for articulating best practices in authorship in scientific research. Emerging from this material is a definition of authorship, as well as policy statements on duplicative publication, conflict of interest disclosure, electronic access, data sharing, digital image integrity, and research requiring subjects' protection, including prior registration of clinical trials. These common elements provide a foundation for teaching about scientific authorship and publication practices across biomedical and life sciences disciplines.

  14. Differential equation analysis in biomedical science and engineering partial differential equation applications with R

    CERN Document Server

    Schiesser, William E

    2014-01-01

    Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields With a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the com

  15. Should there be greater use of preprint servers for publishing reports of biomedical science?

    Science.gov (United States)

    Chalmers, Iain; Glasziou, Paul

    2016-01-01

    Vitek Tracz and Rebecca Lawrence declare the current journal publishing system to be broken beyond repair. They propose that it should be replaced by immediate publication followed by transparent peer review as the starting place for more open and efficient reporting of science. While supporting this general objective, we suggest that research is needed both to understand why biomedical scientists have been slow to take up preprint options, as well as to assess the relative merits of this and other alternatives to journal publishing.

  16. Spacelab Life Sciences 3 biomedical research using the Rhesus Research Facility

    Science.gov (United States)

    Ballard, R. W.; Searby, N. D.; Stone, L. S.; Hogan, R. P.; Viso, M.; Venet, M.

    1992-01-01

    In 1985, a letter of agreement was signed between the French space agency, CNES, and NASA, formally initiating a joint venture called the RHESUS Project. The goal of this project is to provide a facility to fly rhesus monkeys (Macaca mulatta) to support spaceflight experiments which are applicable but not practical to carry out on human subjects. Biomedical investigations in behavior/performance, immunology/microbiology, muscle physiology, cardiopulmonary physiology, bone/calcium physiology, regulatory physiology, and neurophysiology disciplines will be performed. The Rhesus Research Facility, hardware capable of supporting two adult rhesus monkeys in a microgravity environment, is being developed for a first flight on Spacelab Life Sciences in early 1996.

  17. Differential equation analysis in biomedical science and engineering ordinary differential equation applications with R

    CERN Document Server

    Schiesser, William E

    2014-01-01

    Features a solid foundation of mathematical and computational tools to formulate and solve real-world ODE problems across various fields With a step-by-step approach to solving ordinary differential equations (ODEs), Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R successfully applies computational techniques for solving real-worldODE problems that are found in a variety of fields, including chemistry, physics, biology,and physiology. The book provides readers with the necessary knowledge to reproduce andextend the comp

  18. Recent developments in fluorescence-based microscopy applied in biomedical sciences

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The present short review aims to give an overview of the most recent de velopments in fluorescence microscopy and its applications in biomedical science s. Apart from improvements in well-established methods based on conventional fl u orescence microscopy and confocal microscopy (fluorescence in situ hybridisa tion (FISH), tyramide signal amplification (TSA) in immunocytochemistry, new fluorop hores), more recently introduced techniques like fluorescence resonance energy t ransfer (FRET), fluorescence recovery after photobleaching (FRAP), multiphoton m icroscopy and fluorescence correlation spectroscopy (FCS) will be discussed.

  19. Predicting Transition and Adjustment to College: Biomedical and Behavioral Science Aspirants' and Minority Students' First Year of College

    Science.gov (United States)

    Hurtado, Sylvia; Han, June C.; Saenz, Victor B.; Espinosa, Lorelle L.; Cabrera, Nolan L.; Cerna, Oscar S.

    2007-01-01

    The purpose of this study is to explore key factors that impact the college transition of aspiring underrepresented minority students in the biomedical and behavioral sciences, in comparison with White, Asian students and non-science minority students. We examined successful management of the academic environment and sense of belonging during the…

  20. Boundary-Work in the Health Research Field: Biomedical and Clinician Scientists' Perceptions of Social Science Research

    Science.gov (United States)

    Albert, Mathieu; Laberge, Suzanne; Hodges, Brian D.

    2009-01-01

    Funding agencies in Canada are attempting to break down the organizational boundaries between disciplines to promote interdisciplinary research and foster the integration of the social sciences into the health research field. This paper explores the extent to which biomedical and clinician scientists' perceptions of social science research operate…

  1. Biomedical Big Data Training Collaborative (BBDTC): An effort to bridge the talent gap in biomedical science and research.

    Science.gov (United States)

    Purawat, Shweta; Cowart, Charles; Amaro, Rommie E; Altintas, Ilkay

    2016-06-01

    The BBDTC (https://biobigdata.ucsd.edu) is a community-oriented platform to encourage high-quality knowledge dissemination with the aim of growing a well-informed biomedical big data community through collaborative efforts on training and education. The BBDTC collaborative is an e-learning platform that supports the biomedical community to access, develop and deploy open training materials. The BBDTC supports Big Data skill training for biomedical scientists at all levels, and from varied backgrounds. The natural hierarchy of courses allows them to be broken into and handled as modules. Modules can be reused in the context of multiple courses and reshuffled, producing a new and different, dynamic course called a playlist. Users may create playlists to suit their learning requirements and share it with individual users or the wider public. BBDTC leverages the maturity and design of the HUBzero content-management platform for delivering educational content. To facilitate the migration of existing content, the BBDTC supports importing and exporting course material from the edX platform. Migration tools will be extended in the future to support other platforms. Hands-on training software packages, i.e., toolboxes, are supported through Amazon EC2 and Virtualbox virtualization technologies, and they are available as: (i) downloadable lightweight Virtualbox Images providing a standardized software tool environment with software packages and test data on their personal machines, and (ii) remotely accessible Amazon EC2 Virtual Machines for accessing biomedical big data tools and scalable big data experiments. At the moment, the BBDTC site contains three open Biomedical big data training courses with lecture contents, videos and hands-on training utilizing VM toolboxes, covering diverse topics. The courses have enhanced the hands-on learning environment by providing structured content that users can use at their own pace. A four course biomedical big data series is planned

  2. Biomedical Big Data Training Collaborative (BBDTC): An effort to bridge the talent gap in biomedical science and research

    Science.gov (United States)

    Purawat, Shweta; Cowart, Charles; Amaro, Rommie E.; Altintas, Ilkay

    2016-01-01

    The BBDTC (https://biobigdata.ucsd.edu) is a community-oriented platform to encourage high-quality knowledge dissemination with the aim of growing a well-informed biomedical big data community through collaborative efforts on training and education. The BBDTC collaborative is an e-learning platform that supports the biomedical community to access, develop and deploy open training materials. The BBDTC supports Big Data skill training for biomedical scientists at all levels, and from varied backgrounds. The natural hierarchy of courses allows them to be broken into and handled as modules. Modules can be reused in the context of multiple courses and reshuffled, producing a new and different, dynamic course called a playlist. Users may create playlists to suit their learning requirements and share it with individual users or the wider public. BBDTC leverages the maturity and design of the HUBzero content-management platform for delivering educational content. To facilitate the migration of existing content, the BBDTC supports importing and exporting course material from the edX platform. Migration tools will be extended in the future to support other platforms. Hands-on training software packages, i.e., toolboxes, are supported through Amazon EC2 and Virtualbox virtualization technologies, and they are available as: (i) downloadable lightweight Virtualbox Images providing a standardized software tool environment with software packages and test data on their personal machines, and (ii) remotely accessible Amazon EC2 Virtual Machines for accessing biomedical big data tools and scalable big data experiments. At the moment, the BBDTC site contains three open Biomedical big data training courses with lecture contents, videos and hands-on training utilizing VM toolboxes, covering diverse topics. The courses have enhanced the hands-on learning environment by providing structured content that users can use at their own pace. A four course biomedical big data series is planned

  3. Lecture 10: The European Bioinformatics Institute - "Big data" for biomedical sciences

    CERN Document Server

    CERN. Geneva; Dana, Jose

    2013-01-01

    Part 1: Big data for biomedical sciences (Tom Hancocks) Ten years ago witnessed the completion of the first international 'Big Biology' project that sequenced the human genome. In the years since biological sciences, have seen a vast growth in data. In the coming years advances will come from integration of experimental approaches and the translation into applied technologies is the hospital, clinic and even at home. This talk will examine the development of infrastructure, physical and virtual, that will allow millions of life scientists across Europe better access to biological data Tom studied Human Genetics at the University of Leeds and McMaster University, before completing an MSc in Analytical Genomics at the University of Birmingham. He has worked for the UK National Health Service in diagnostic genetics and in training healthcare scientists and clinicians in bioinformatics. Tom joined the EBI in 2012 and is responsible for the scientific development and delivery of training for the BioMedBridges pr...

  4. Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report. Appendix

    Science.gov (United States)

    Achieve, Inc., 2010

    2010-01-01

    This appendix accompanies the report "Taking the Lead in Science Education: Forging Next-Generation Science Standards. International Science Benchmarking Report," a study conducted by Achieve to compare the science standards of 10 countries. This appendix includes the following: (1) PISA and TIMSS Assessment Rankings; (2) Courses and…

  5. Hegemony in the marketplace of biomedical innovation: consumer demand and stem cell science.

    Science.gov (United States)

    Salter, Brian; Zhou, Yinhua; Datta, Saheli

    2015-04-01

    The global political economy of stem cell therapies is characterised by an established biomedical hegemony of expertise, governance and values in collision with an increasingly informed health consumer demand able to define and pursue its own interest. How does the hegemony then deal with the challenge from the consumer market and what does this tell us about its modus operandi? In developing a theoretical framework to answer these questions, the paper begins with an analysis of the nature of the hegemony of biomedical innovation in general, its close relationship with the research funding market, the current political modes of consumer incorporation, and the ideological role performed by bioethics as legitimating agency. Secondly, taking the case of stem cell innovation, it explores the hegemonic challenge posed by consumer demand working through the global practice based market of medical innovation, the response of the national and international institutions of science and their reassertion of the values of the orthodox model, and the supporting contribution of bioethics. Finally, the paper addresses the tensions within the hegemonic model of stem cell innovation between the key roles and values of scientist and clinician, the exacerbation of these tensions by the increasingly visible demands of health consumers, and the emergence of political compromise.

  6. Biomedical laboratory science education: standardising teaching content in resource-limited countries

    Directory of Open Access Journals (Sweden)

    Wendy Arneson

    2013-03-01

    Full Text Available Background: There is a worldwide shortage of qualified laboratory personnel to provide adequate testing for the detection and monitoring of diseases. In an effort to increase laboratory capacity in developing countries, new skills have been introduced into laboratory services. Curriculum revision with a focus on good laboratory practice is an important aspect of supplying entry-level graduates with the competencies needed to meet the current needs.Objectives: Gaps in application and problem-solving competencies of newly graduated laboratory personnel were discovered in Ethiopia, Tanzania and Kenya. New medical laboratory teaching content was developed in Ethiopia, Tanzania and Kenya using national instructors, tutors, and experts and consulting medical laboratory educators from the United States of America (USA.Method: Workshops were held in Ethiopia to create standardised biomedical laboratory science (BMLS lessons based on recently-revised course objectives with an emphasis on application of skills. In Tanzania, course-module teaching guides with objectives were developed based on established competency outcomes and tasks. In Kenya, example interactive presentations and lesson plans were developed by the USA medical laboratory educators prior to the workshop to serve as resources and templates for the development of lessons within the country itself.Results: The new teaching materials were implemented and faculty, students and other stakeholders reported successful outcomes.Conclusions: These approaches to updating curricula may be helpful as biomedical laboratory schools in other countries address gaps in the competencies of entry-level graduates.

  7. Applications of 14C-AMS in biomedical sciences (Bio-14C-AMS)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Accelerator mass spectrometry (AMS) is an ultrasensitive measure for tracing 14C labeled molecules in vivo or detecting the biomarker for assessment of carcinogenesis. In this review, basic principles, wide applications and new progresses of 14C-bio-AMS are presented. It has been a new advanced tool for measuring the adduction of biologcial molecules with xenobiotics, including carcinogens, drugs, agrochemicals, nicotine, etc. The successful applications have proven the effectiveness of AMS to assessing cancer risk, screening drug toxicity and studying nutrients uptake. In particular, AMS is characterized by measuring xenobiotics at very low dose levels relevant to human environmental exposure. It is sensitive and precise to an attomole (10-18 mole) or less of 14C per mg carbon. Although it has some shortcomings, undoubtedly, AMS possesses an evident merit of high sensitivity and will have widespread applications in the biomedical sciences.

  8. Additive manufacturing in biomedical sciences and the need for definitions and norms.

    Science.gov (United States)

    Chhaya, Mohit P; Poh, Patrina S P; Balmayor, Elizabeth R; van Griensven, Martijn; Schantz, Jan-Thorsten; Hutmacher, Dietmar W

    2015-01-01

    The application of additive biomanufacturing represents one of the most rapidly advancing areas of biomedical science, in which engineers, scientists, and clinicians are contributing to the future of health care. The combined efforts of a large number of groups around the globe have developed a strong research thrust that has resulted in a large number of publications. Reviewing this body of literature, there is an increasing trend of research groups inventing their own definitions and terminology. This has made it difficult to find and compare the results. Therefore, to move the field constructively forward, it is a conditio sine qua non to clarify various terminologies and standards. Based on this background, this article advocates tightening the terminology and has the objective of penning out definitions that will ultimately allow the development of official industry standard terms, such as American Society for Testing and Materials and or International Organization for Standardization for technologies developed for Tissue Engineering and Regenerative Medicine.

  9. Advancement and applications of peptide phage display technology in biomedical science.

    Science.gov (United States)

    Wu, Chien-Hsun; Liu, I-Ju; Lu, Ruei-Min; Wu, Han-Chung

    2016-01-01

    Combinatorial phage library is a powerful research tool for high-throughput screening of protein interactions. Of all available molecular display techniques, phage display has proven to be the most popular approach. Screening phage-displayed random peptide libraries is an effective means of identifying peptides that can bind target molecules and regulate their function. Phage-displayed peptide libraries can be used for (i) B-cell and T-cell epitope mapping, (ii) selection of bioactive peptides bound to receptors or proteins, disease-specific antigen mimics, peptides bound to non-protein targets, cell-specific peptides, or organ-specific peptides, and (iii) development of peptide-mediated drug delivery systems and other applications. Targeting peptides identified using phage display technology may be useful for basic research and translational medicine. In this review article, we summarize the latest technological advancements in the application of phage-displayed peptide libraries to applied biomedical sciences.

  10. Exploring lecturers' views of first-year health science students' misconceptions in biomedical domains.

    Science.gov (United States)

    Badenhorst, Elmi; Mamede, Sílvia; Hartman, Nadia; Schmidt, Henk G

    2015-05-01

    Research has indicated that misconceptions hamper the process of knowledge construction. Misconceptions are defined as persistent ideas not supported by current scientific views. Few studies have explored how misconceptions develop when first year health students conceptually move between anatomy and physiology to construct coherent knowledge about the human body. This explorative study analysed lecturers' perceptions of first-year health science students' misconceptions in anatomy and physiology to gain a deeper understanding of how and why misconceptions could potentially arise, by attempting to link sources of misconceptions with four schools of thought, namely theories on concept formation, complexity, constructivism and conceptual change. This was a qualitative study where ten lecturers involved in teaching anatomy and physiology in the health science curricula at the University of Cape Town were interviewed to explore perceptions of students' misconceptions. Analytical induction was used to uncover categories within the interview data by using a coding system. A deeper analysis was done to identify emerging themes that begins to explore a theoretical understanding of why and how misconceptions arise. Nine sources of misconceptions were identified, including misconceptions related to language, perception, three dimensional thinking, causal reasoning, curricula design, learning styles and moving between macro and micro levels. The sources of misconceptions were then grouped together to assist educators with finding educational interventions to overcome potential misconceptions. This explorative study is an attempt in theory building to understand what is at the core of biomedical misconceptions. Misconceptions identified in this study hold implications for educators as not all students have the required building blocks and cognitive skills to successfully navigate their way through biomedical courses. Theoretical insight into the sources of misconceptions can

  11. Biomedical and environmental sciences programs at the Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Preston, E.L.; Getsi, J.A. (comps.)

    1982-07-01

    A major objective of the biomedical and environmental sciences (BES) research at the Oak Ridge National Laboratory (ORNL) is to provide information on environmental, health, and safety considerations that can be used in the formulation and implementation of energy technology decisions. Research is directed at securing information required for an understanding of both the short- and long-term consequences of the processes involved in new energy technologies. Investigation of the mechanisms responsible for biological and ecological damage caused by substances associated with energy production and of repair mechanisms is a necessary component of this research. The research is carried out by the staff of four divisions and one program: Biology Division, Environmental Sciences Division, Health and Safety Research Division, Information Division, and the Life Sciences Synthetic Fuels Program. Research programs underway in each of these divisions are discussed. Information on the following subjects is also included: interactions with universities; interactions with industry; technology transfer; recent accomplishments in the areas of program, publications, awards, and patents; and new initiatives. (JGB)

  12. Adventurism in biomedical science: Washington University-Monsanto program in biotechnology.

    Science.gov (United States)

    Gordon, J I

    1992-01-01

    The Washington University-Monsanto relationship has supported innovation in the biological sciences. It has done so in part by making the fence between an industrial and an academic institution more transparent and more easy to cross. A unique means of promoting intellectual adventurism may be lost, however, if this type of relationship is not structured to maximize the likelihood of obtaining products or if products are the only financial benefit that the industrial partner can derive from such interactions (for example other benefits could include governmental R&D tax credits for those relationships that satisfy some minimal criteria for size and/or length of commitment). I hope that this and other forms of industrial-university relationships that encourage discovery by providing institutional support for new ideas will flourish. Whatever their fate, the responsibility for promoting dreams must be shared by all of us: by those who are privileged to have students in their labs, by academic institutions as they seek to define their roles in the next century, by peer review boards, by national science policymakers, and perhaps by industry. I have presented the Washington University-Monsanto collaboration not as a complete answer to the question of how to promote intellectual adventurism in the biomedical sciences but rather as a concrete response to a problem that must be clearly articulated, thoroughly examined, and creatively addressed.

  13. Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences.

    Science.gov (United States)

    Jun, Young-Wook; Seo, Jung-Wook; Cheon, Jinwoo

    2008-02-01

    Magnetic nanoparticles, which exhibit a variety of unique magnetic phenomena that are drastically different from those of their bulk counterparts, are garnering significant interest since these properties can be advantageous for utilization in a variety of applications ranging from storage media for magnetic memory devices to probes and vectors in the biomedical sciences. In this Account, we discuss the nanoscaling laws of magnetic nanoparticles including metals, metal ferrites, and metal alloys, while focusing on their size, shape, and composition effects. Their fundamental magnetic properties such as blocking temperature (Tb), spin life time (tau), coercivity (Hc), and susceptibility (chi) are strongly influenced by the nanoscaling laws, and as a result, these scaling relationships can be leveraged to control magnetism from the ferromagnetic to the superparamagnetic regimes. At the same time, they can be used in order to tune magnetic values including Hc, chi, and remanence (Mr). For example, life time of magnetic spin is directly related to the magnetic anisotropy energy (KuV) and also the size and volume of nanoparticles. The blocking temperature (Tb) changes from room temperature to 10 K as the size of cobalt nanoparticles is reduced from 13 to 2 nm. Similarly, H c is highly susceptible to the anisotropy of nanoparticles, while saturation magnetization is directly related to the canting effects of the disordered surface magnetic spins and follows a linear relationship upon plotting of ms (1/3) vs r(-1). Therefore, the nanoscaling laws of magnetic nanoparticles are important not only for understanding the behavior of existing materials but also for developing novel nanomaterials with superior properties. Since magnetic nanoparticles can be easily conjugated with biologically important constituents such as DNA, peptides, and antibodies, it is possible to construct versatile nano-bio hybrid particles, which simultaneously possess magnetic and biological functions

  14. Developmental programming: State-of-the-science and future directions-summary from a Pennington biomedical symposium

    Science.gov (United States)

    On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current s...

  15. The role biomedical science laboratories can play in improving science knowledge and promoting first-year nursing academic success

    Science.gov (United States)

    Arneson, Pam

    The Role Biomedical Science Laboratories Can Play In Improving Science Knowledge and Promoting First-Year Nursing Academic Success The need for additional nursing and health care professionals is expected to increase dramatically over the next 20 years. With this in mind, students must have strong biomedical science knowledge to be competent in their field. Some studies have shown that participation in bioscience laboratories can enhance science knowledge. If this is true, an analysis of the role bioscience labs have in first-year nursing academic success is apposite. In response, this study sought to determine whether concurrent enrollment in anatomy and microbiology lecture and lab courses improved final lecture course grades. The investigation was expanded to include a comparison of first-year nursing GPA and prerequisite bioscience concurrent lecture/lab enrollment. Additionally, research has indicated that learning is affected by student perception of the course, instructor, content, and environment. To gain an insight regarding students' perspectives of laboratory courses, almost 100 students completed a 20-statement perception survey to understand how lab participation affects learning. Data analyses involved comparing anatomy and microbiology final lecture course grades between students who concurrently enrolled in the lecture and lab courses and students who completed the lecture course alone. Independent t test analyses revealed that there was no significant difference between the groups for anatomy, t(285) = .11, p = .912, but for microbiology, the lab course provided a significant educational benefit, t(256) = 4.47, p = .000. However, when concurrent prerequisite bioscience lecture/lab enrollment was compared to non-concurrent enrollment for first-year nursing GPA using independent t test analyses, no significant difference was found for South Dakota State University, t(37) = -1.57, p = .125, or for the University of South Dakota, t(38) = -0.46, p

  16. Teaching of parasitology to students of veterinary medicine and biomedical sciences.

    Science.gov (United States)

    Thompson, R C A; Lymbery, A J; Hobbs, R P

    2002-10-02

    The teaching of an applied parasitology course suitable for both veterinary and biomedical students is described. A common lecture course is given complemented by separate and specific practical, research and problem-based learning components designed for veterinary and biomedical students. For veterinary and biomedical students, teaching of parasitology during the full course comprises a total of 46 lectures; 13 practical classes for veterinary students and five for biomedical students who also undertake an independent research project.

  17. Creating a pipeline of talent for informatics: STEM initiative for high school students in computer science, biology, and biomedical informatics.

    Science.gov (United States)

    Dutta-Moscato, Joyeeta; Gopalakrishnan, Vanathi; Lotze, Michael T; Becich, Michael J

    2014-01-01

    This editorial provides insights into how informatics can attract highly trained students by involving them in science, technology, engineering, and math (STEM) training at the high school level and continuing to provide mentorship and research opportunities through the formative years of their education. Our central premise is that the trajectory necessary to be expert in the emergent fields in front of them requires acceleration at an early time point. Both pathology (and biomedical) informatics are new disciplines which would benefit from involvement by students at an early stage of their education. In 2009, Michael T Lotze MD, Kirsten Livesey (then a medical student, now a medical resident at University of Pittsburgh Medical Center (UPMC)), Richard Hersheberger, PhD (Currently, Dean at Roswell Park), and Megan Seippel, MS (the administrator) launched the University of Pittsburgh Cancer Institute (UPCI) Summer Academy to bring high school students for an 8 week summer academy focused on Cancer Biology. Initially, pathology and biomedical informatics were involved only in the classroom component of the UPCI Summer Academy. In 2011, due to popular interest, an informatics track called Computer Science, Biology and Biomedical Informatics (CoSBBI) was launched. CoSBBI currently acts as a feeder program for the undergraduate degree program in bioinformatics at the University of Pittsburgh, which is a joint degree offered by the Departments of Biology and Computer Science. We believe training in bioinformatics is the best foundation for students interested in future careers in pathology informatics or biomedical informatics. We describe our approach to the recruitment, training and research mentoring of high school students to create a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics. We emphasize here how mentoring of high school students in pathology informatics and biomedical informatics

  18. Creating a pipeline of talent for informatics: STEM initiative for high school students in computer science, biology, and biomedical informatics

    Directory of Open Access Journals (Sweden)

    Joyeeta Dutta-Moscato

    2014-01-01

    Full Text Available This editorial provides insights into how informatics can attract highly trained students by involving them in science, technology, engineering, and math (STEM training at the high school level and continuing to provide mentorship and research opportunities through the formative years of their education. Our central premise is that the trajectory necessary to be expert in the emergent fields in front of them requires acceleration at an early time point. Both pathology (and biomedical informatics are new disciplines which would benefit from involvement by students at an early stage of their education. In 2009, Michael T Lotze MD, Kirsten Livesey (then a medical student, now a medical resident at University of Pittsburgh Medical Center (UPMC, Richard Hersheberger, PhD (Currently, Dean at Roswell Park, and Megan Seippel, MS (the administrator launched the University of Pittsburgh Cancer Institute (UPCI Summer Academy to bring high school students for an 8 week summer academy focused on Cancer Biology. Initially, pathology and biomedical informatics were involved only in the classroom component of the UPCI Summer Academy. In 2011, due to popular interest, an informatics track called Computer Science, Biology and Biomedical Informatics (CoSBBI was launched. CoSBBI currently acts as a feeder program for the undergraduate degree program in bioinformatics at the University of Pittsburgh, which is a joint degree offered by the Departments of Biology and Computer Science. We believe training in bioinformatics is the best foundation for students interested in future careers in pathology informatics or biomedical informatics. We describe our approach to the recruitment, training and research mentoring of high school students to create a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics. We emphasize here how mentoring of high school students in pathology informatics and biomedical

  19. Programmatic Efforts at the National Institutes of Health to Promote and Support the Careers of Women in Biomedical Science.

    Science.gov (United States)

    Plank-Bazinet, Jennifer L; Bunker Whittington, Kjersten; Cassidy, Sara K B; Filart, Rosemarie; Cornelison, Terri L; Begg, Lisa; Austin Clayton, Janine

    2016-08-01

    Although women have reached parity at the training level in the biological sciences and medicine, they are still significantly underrepresented in the professoriate and in mid- and senior-level life science positions. Considerable effort has been devoted by individuals and organizations across science sectors to understanding this disparity and to developing interventions in support of women's career development. The National Institutes of Health (NIH) formed the Office of Research on Women's Health (ORWH) in 1990 with the goals of supporting initiatives to improve women's health and providing opportunities and support for the recruitment, retention, reentry, and sustained advancement of women in biomedical careers. Here, the authors review several accomplishments and flagship activities initiated by the NIH and ORWH in support of women's career development during this time. These include programming to support researchers returning to the workforce after a period away (Research Supplements to Promote Reentry into Biomedical and Behavioral Research Careers), career development awards made through the Building Interdisciplinary Research Careers in Women's Health program, and trans-NIH involvement and activities stemming from the NIH Working Group on Women in Biomedical Careers. These innovative programs have contributed to advancement of women by supporting the professional and personal needs of women in science. The authors discuss the unique opportunities that accompany NIH partnerships with the scientific community, and conclude with a summary of the impact of these programs on women in science.

  20. Low statistical power in biomedical science: a review of three human research domains

    Science.gov (United States)

    Dumas-Mallet, Estelle; Button, Katherine S.; Boraud, Thomas; Gonon, Francois

    2017-01-01

    Studies with low statistical power increase the likelihood that a statistically significant finding represents a false positive result. We conducted a review of meta-analyses of studies investigating the association of biological, environmental or cognitive parameters with neurological, psychiatric and somatic diseases, excluding treatment studies, in order to estimate the average statistical power across these domains. Taking the effect size indicated by a meta-analysis as the best estimate of the likely true effect size, and assuming a threshold for declaring statistical significance of 5%, we found that approximately 50% of studies have statistical power in the 0–10% or 11–20% range, well below the minimum of 80% that is often considered conventional. Studies with low statistical power appear to be common in the biomedical sciences, at least in the specific subject areas captured by our search strategy. However, we also observe evidence that this depends in part on research methodology, with candidate gene studies showing very low average power and studies using cognitive/behavioural measures showing high average power. This warrants further investigation.

  1. An Overview of SBIR Phase 2 Physical Sciences and Biomedical Technologies in Space

    Science.gov (United States)

    Nguyen, Hung D.; Steele, Gynelle C.

    2015-01-01

    Technological innovation is the overall focus of NASA's Small Business Innovation Research (SBIR) program. The program invests in the development of innovative concepts and technologies to help NASA's mission directorates address critical research and development needs for agency projects. This report highlights innovative SBIR Phase II projects from 2007-2012 specifically addressing areas in physical sciences and biomedical technologies in space, which is one of six core competencies at NASA Glenn Research Center. There are twenty two technologies featured with emphasis on a wide spectrum of applications such as reusable handheld electrolyte, sensor for bone markers, wideband single crystal transducer, mini treadmill for musculoskeletal, and much more. Each article in this report describes an innovation, technical objective, and highlights NASA commercial and industrial applications. This report serves as an opportunity for NASA personnel including engineers, researchers, and program managers to learn of NASA SBIR's capabilities that might be crosscutting into this technology area. As the result, it would cause collaborations and partnerships between the small companies and NASA Programs and Projects resulting in benefit to both SBIR companies and NASA.

  2. Pacific Northwest Laboratory annual report for 1994 to the DOE Office of Energy Research Part 1: Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1995-04-01

    Research in the biomedical sciences at PNL is described. Activities reported include: inhaled plutonium in dogs; national radiobiology archives; statistical analysis of data from animal studies; genotoxicity of inhaled energy effluents; molecular events during tumor initiation; biochemistry of free radical induced DNA damage; radon hazards in homes; mechanisms of radon injury; genetics of radon induced lung cancer; and in vivo/in vitro radon induced cellular damage.

  3. Development of Biomedical Polymer-Silicate Nanocomposites: A Materials Science Perspective

    Directory of Open Access Journals (Sweden)

    Chia-Jung Wu

    2010-04-01

    Full Text Available Biomedical polymer-silicate nanocomposites have potential to become critically important to the development of biomedical applications, ranging from diagnostic and therapeutic devices, tissue regeneration and drug delivery matrixes to various bio-technologies that are inspired by biology but have only indirect biomedical relation. The fundamental understanding of polymer-nanoparticle interactions is absolutely necessary to control structure-property relationships of materials that need to work within the chemical, physical and biological constraints required by an application. This review summarizes the most recent published strategies to design and develop polymer-silicate nanocomposites (including clay based silicate nanoparticles and bioactive glass nanoparticles for a variety of biomedical applications. Emerging trends in bio-technological and biomedical nanocomposites are highlighted and potential new fields of applications are examined.

  4. How can we improve Science, Technology, Engineering, and Math education to encourage careers in Biomedical and Pathology Informatics?

    Directory of Open Access Journals (Sweden)

    Rahul Uppal

    2016-01-01

    Full Text Available The Computer Science, Biology, and Biomedical Informatics (CoSBBI program was initiated in 2011 to expose the critical role of informatics in biomedicine to talented high school students.[1] By involving them in Science, Technology, Engineering, and Math (STEM training at the high school level and providing mentorship and research opportunities throughout the formative years of their education, CoSBBI creates a research infrastructure designed to develop young informaticians. Our central premise is that the trajectory necessary to be an expert in the emerging fields of biomedical informatics and pathology informatics requires accelerated learning at an early age.In our 4th year of CoSBBI as a part of the University of Pittsburgh Cancer Institute (UPCI Academy (http://www.upci.upmc.edu/summeracademy/, and our 2nd year of CoSBBI as an independent informatics-based academy, we enhanced our classroom curriculum, added hands-on computer science instruction, and expanded research projects to include clinical informatics. We also conducted a qualitative evaluation of the program to identify areas that need improvement in order to achieve our goal of creating a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics in the era of big data and personalized medicine.

  5. How can we improve Science, Technology, Engineering, and Math education to encourage careers in Biomedical and Pathology Informatics?

    Science.gov (United States)

    Uppal, Rahul; Mandava, Gunasheil; Romagnoli, Katrina M; King, Andrew J; Draper, Amie J; Handen, Adam L; Fisher, Arielle M; Becich, Michael J; Dutta-Moscato, Joyeeta

    2016-01-01

    The Computer Science, Biology, and Biomedical Informatics (CoSBBI) program was initiated in 2011 to expose the critical role of informatics in biomedicine to talented high school students.[1] By involving them in Science, Technology, Engineering, and Math (STEM) training at the high school level and providing mentorship and research opportunities throughout the formative years of their education, CoSBBI creates a research infrastructure designed to develop young informaticians. Our central premise is that the trajectory necessary to be an expert in the emerging fields of biomedical informatics and pathology informatics requires accelerated learning at an early age.In our 4(th) year of CoSBBI as a part of the University of Pittsburgh Cancer Institute (UPCI) Academy (http://www.upci.upmc.edu/summeracademy/), and our 2nd year of CoSBBI as an independent informatics-based academy, we enhanced our classroom curriculum, added hands-on computer science instruction, and expanded research projects to include clinical informatics. We also conducted a qualitative evaluation of the program to identify areas that need improvement in order to achieve our goal of creating a pipeline of exceptionally well-trained applicants for both the disciplines of pathology informatics and biomedical informatics in the era of big data and personalized medicine.

  6. An Interactive, Integrated, Instructional Pathway to the LEAD Science Gateway

    Science.gov (United States)

    Yalda, S.; Clark, R.; Davis, L.; Wiziecki, E. N.

    2008-12-01

    Linked Environments for Atmospheric Discovery (LEAD) is a bold and revolutionary paradigm that through a Web-based Service Oriented Architecture (SOA) exposes the user to a rich environment of data, models, data mining and visualization and analysis tools, enabling the user to ask science questions of applications while the complexity of the software and middleware managing these applications is hidden from the user. From its inception in 2003, LEAD has championed goals that have context for the future of weather and related research and education. LEAD espouses to lowering the barrier for using complex end-to-end weather technologies by a) democratizing the availability of advanced weather technologies, b) empowering the user of these technologies to tackle a variety of problems, and c) facilitating learning and understanding. LEAD, as it exists today, is poised to enable a diverse community of scientists, educators, students, and operational practitioners. The project has been informed by atmospheric and computer scientists, educators, and educational consultants who, in search of new knowledge, understanding, ideas, and learning methodologies, seek easy access to new capabilities that allow for user-directed and interactive query and acquisition, simulation, assimilation, data mining, computational modeling, and visualization. As one component of the total LEAD effort, the LEAD education team has designed interactive, integrated, instructional pathways within a set of learning modules (LEAD-to-Learn) to facilitate, enhance, and enable the use of the LEAD gateway in the classroom. The LEAD education initiative focuses on the means to integrate data, tools, and services used by researchers into undergraduate meteorology education in order to provide an authentic and contextualized environment for teaching and learning. Educators, educational specialists, and students from meteorology and computer science backgrounds have collaborated on the design and development

  7. Biomedical Engineering

    CERN Document Server

    Suh, Sang C; Tanik, Murat M

    2011-01-01

    Biomedical Engineering: Health Care Systems, Technology and Techniques is an edited volume with contributions from world experts. It provides readers with unique contributions related to current research and future healthcare systems. Practitioners and researchers focused on computer science, bioinformatics, engineering and medicine will find this book a valuable reference.

  8. Blazing the trail essays by leading women in science

    CERN Document Server

    Ideal, Emma

    2013-01-01

    Name a famous scientist. Got one? Now name a famous physicist. Ok, now name a famous female physicist. Ok, now name a famous living female physicist. Stumped? In Blazing the Trail: Essays by Leading Women in Science, 35 highly successful physicists, engineers, and chemists share their personal histories, their passion for discovery, and their secrets for success with the next generation. Essayists candidly recount their experiences – both positive and negative – with an uplifting tone, focusing on lessons learned along the way. The combination of personal stories and advice sends a powerful message to all young women considering scientific careers: I did it, so can you. Here’s how.

  9. Preparing for the unexpected: the pivotal role of social and behavioral sciences in trials of biomedical HIV prevention interventions.

    Science.gov (United States)

    Koblin, Beryl A; Andrasik, Michele; Austin, Judy

    2013-07-01

    A range of efficacies have been reported for biomedical HIV prevention interventions, including antiretroviral treatment, male circumcision, preexposure prophylaxis, microbicides, and preventive vaccines. This range of efficacies probably results from the influence of multiple inputs and processes during trials, including the strength and target of the intervention, host factors, target population characteristics, level of HIV exposure, and intervention dose. Expertise in social and behavioral sciences, in conjunction with basic science, clinical research, epidemiology, biostatistics, and community, is needed to understand the influence of these inputs and processes on intervention efficacy, improve trial design and implementation, and enable interpretation of trial results. In particular, social and behavioral sciences provide the means for investigating and identifying populations suitable for recruitment into and retention in trials and for developing and improving measures of HIV exposure and intervention dose, all within the larger sociocultural context. Integration of social and behavioral sciences early in idea generation and study design is imperative for the successful conduct of biomedical trials and for ensuring optimal data collection approaches necessary for the interpretation of findings, particularly in cases of unexpected results.

  10. Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives

    DEFF Research Database (Denmark)

    Schroter, Sara; Groves, Trish; Højgaard, Liselotte

    2010-01-01

    The objectives of this research were (a) to describe the current status of grant review for biomedical projects and programmes from the perspectives of international funding organisations and grant reviewers, and (b) to explore funders' interest in developing uniform requirements for grant review...... aimed at making the processes and practices of grant review more consistent, transparent, and user friendly....

  11. Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives

    DEFF Research Database (Denmark)

    Schroter, Sara; Groves, Trish; Højgaard, Liselotte

    2010-01-01

    The objectives of this research were (a) to describe the current status of grant review for biomedical projects and programmes from the perspectives of international funding organisations and grant reviewers, and (b) to explore funders' interest in developing uniform requirements for grant review...

  12. Understanding public opinion in debates over biomedical research: looking beyond political partisanship to focus on beliefs about science and society.

    Science.gov (United States)

    Nisbet, Matthew; Markowitz, Ezra M

    2014-01-01

    As social scientists have investigated the political and social factors influencing public opinion in science-related policy debates, there has been growing interest in the implications of this research for public communication and outreach. Given the level of political polarization in the United States, much of the focus has been on partisan differences in public opinion, the strategies employed by political leaders and advocates that promote those differences, and the counter-strategies for overcoming them. Yet this focus on partisan differences tends to overlook the processes by which core beliefs about science and society impact public opinion and how these schema are often activated by specific frames of reference embedded in media coverage and popular discourse. In this study, analyzing cross-sectional, nationally representative survey data collected between 2002 and 2010, we investigate the relative influence of political partisanship and science-related schema on Americans' support for embryonic stem cell research. In comparison to the influence of partisan identity, our findings suggest that generalized beliefs about science and society were more chronically accessible, less volatile in relation to media attention and focusing events, and an overall stronger influence on public opinion. Classifying respondents into four unique audience groups based on their beliefs about science and society, we additionally find that individuals within each of these groups split relatively evenly by partisanship but differ on other important dimensions. The implications for public engagement and future research on controversies related to biomedical science are discussed.

  13. Understanding public opinion in debates over biomedical research: looking beyond political partisanship to focus on beliefs about science and society.

    Directory of Open Access Journals (Sweden)

    Matthew Nisbet

    Full Text Available As social scientists have investigated the political and social factors influencing public opinion in science-related policy debates, there has been growing interest in the implications of this research for public communication and outreach. Given the level of political polarization in the United States, much of the focus has been on partisan differences in public opinion, the strategies employed by political leaders and advocates that promote those differences, and the counter-strategies for overcoming them. Yet this focus on partisan differences tends to overlook the processes by which core beliefs about science and society impact public opinion and how these schema are often activated by specific frames of reference embedded in media coverage and popular discourse. In this study, analyzing cross-sectional, nationally representative survey data collected between 2002 and 2010, we investigate the relative influence of political partisanship and science-related schema on Americans' support for embryonic stem cell research. In comparison to the influence of partisan identity, our findings suggest that generalized beliefs about science and society were more chronically accessible, less volatile in relation to media attention and focusing events, and an overall stronger influence on public opinion. Classifying respondents into four unique audience groups based on their beliefs about science and society, we additionally find that individuals within each of these groups split relatively evenly by partisanship but differ on other important dimensions. The implications for public engagement and future research on controversies related to biomedical science are discussed.

  14. Uptake of Optional Activities Leads to Improved Performance in a Biomedical Sciences Class

    Science.gov (United States)

    Verkade, Heather; Lim, Saw Hoon

    2015-01-01

    Optional (non-assessed) learning activities are a learning tool that may help students achieve their desired grade, or help students with lower levels of previous experience in the topic. This study examines the implementation of, and outcomes from, two optional activities, one online and one paper-based. The activities complemented the lectures…

  15. Applications of systems science in biomedical research regarding obesity and noncommunicable chronic diseases: opportunities, promise, and challenges.

    Science.gov (United States)

    Wang, Youfa; Xue, Hong; Liu, Shiyong

    2015-01-01

    Interest in the application of systems science (SS) in biomedical research, particularly regarding obesity and noncommunicable chronic disease (NCD) research, has been growing rapidly over the past decade. SS is a broad term referring to a family of research approaches that include modeling. As an emerging approach being adopted in public health, SS focuses on the complex dynamic interaction between agents (e.g., people) and subsystems defined at different levels. SS provides a conceptual framework for interdisciplinary and transdisciplinary approaches that address complex problems. SS has unique advantages for studying obesity and NCD problems in comparison to the traditional analytic approaches. The application of SS in biomedical research dates back to the 1960s with the development of computing capacity and simulation software. In recent decades, SS has been applied to addressing the growing global obesity epidemic. There is growing appreciation and support for using SS in the public health field, with many promising opportunities. There are also many challenges and uncertainties, including methodologic, funding, and institutional barriers. Integrated efforts by stakeholders that address these challenges are critical for the successful application of SS in the future.

  16. Computer Science, Biology and Biomedical Informatics academy: Outcomes from 5 years of Immersing High-school Students into Informatics Research.

    Science.gov (United States)

    King, Andrew J; Fisher, Arielle M; Becich, Michael J; Boone, David N

    2017-01-01

    The University of Pittsburgh's Department of Biomedical Informatics and Division of Pathology Informatics created a Science, Technology, Engineering, and Mathematics (STEM) pipeline in 2011 dedicated to providing cutting-edge informatics research and career preparatory experiences to a diverse group of highly motivated high-school students. In this third editorial installment describing the program, we provide a brief overview of the pipeline, report on achievements of the past scholars, and present results from self-reported assessments by the 2015 cohort of scholars. The pipeline continues to expand with the 2015 addition of the innovation internship, and the introduction of a program in 2016 aimed at offering first-time research experiences to undergraduates who are underrepresented in pathology and biomedical informatics. Achievements of program scholars include authorship of journal articles, symposium and summit presentations, and attendance at top 25 universities. All of our alumni matriculated into higher education and 90% remain in STEM majors. The 2015 high-school program had ten participating scholars who self-reported gains in confidence in their research abilities and understanding of what it means to be a scientist.

  17. The diversity of experimental organisms in biomedical research may be influenced by biomedical funding.

    Science.gov (United States)

    Erick Peirson, B R; Kropp, Heather; Damerow, Julia; Laubichler, Manfred D

    2017-03-30

    Contrary to concerns of some critics, we present evidence that biomedical research is not dominated by a small handful of model organisms. An exhaustive analysis of research literature suggests that the diversity of experimental organisms in biomedical research has increased substantially since 1975. There has been a longstanding worry that organism-centric funding policies can lead to biases in experimental organism choice, and thus negatively impact the direction of research and the interpretation of results. Critics have argued that a focus on model organisms has unduly constrained the diversity of experimental organisms. The availability of large electronic databases of scientific literature, combined with interest in quantitative methods among philosophers of science, presents new opportunities for data-driven investigations into organism choice in biomedical research. The diversity of organisms used in NIH-funded research may be considerably lower than in the broader biomedical sciences, and may be subject to greater constraints on organism choice.

  18. Earth Sciences Division annual report 1981. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    1982-09-01

    Separate abstracts were prepared for the 59 papers of the 1981 annual report of the Earth Sciences Division at Lawrence Berkeley Laboratory. The general topics covered included nuclear waste isolation, geophysics and reservoir engineering, and geosciences. (KRM)

  19. Rhythm Analysis by Heartbeat Classification in the Electrocardiogram (Review article of the research achievements of the members of the Centre of Biomedical Engineering, Bulgarian Academy of Sciences

    Directory of Open Access Journals (Sweden)

    Irena Jekova

    2009-08-01

    Full Text Available The morphological and rhythm analysis of the electrocardiogram (ECG is based on ventricular beats detection, wave parameters measurement, as amplitudes, widths, polarities, intervals and relations between them, and a subsequent classification supporting the diagnostic process. Number of algorithms for detection and classification of the QRS complexes have been developed by researchers in the Centre of Biomedical Engineering - Bulgarian Academy of Sciences, and are reviewed in this material. Combined criteria have been introduced dealing with the QRS areas and amplitudes, the waveshapes evaluated by steep slopes and sharp peaks, vectorcardiographic (VCG loop descriptors, RR intervals irregularities. Algorithms have been designed for application on a single ECG lead, a synthesized lead derived by multichannel synchronous recordings, or simultaneous multilead analysis. Some approaches are based on templates matching, cross-correlation or rely on a continuous updating of adaptive thresholds. Various beat classification methods have been designed involving discriminant analysis, the K-th nearest neighbors, fuzzy sets, genetic algorithms, neural networks, etc. The efficiency of the developed methods has been assessed using internationally recognized arrhythmia ECG databases with annotated beats and rhythm disturbances. In general, high values for specificity and sensitivity competitive to those reported in the literature have been achieved.

  20. Biomedical and veterinary science can increase our understanding of coral disease

    Science.gov (United States)

    Work, Thierry M.; Richardson, Laurie L.; Reynolds, T.L.; Willis, Bette L.

    2008-01-01

    A balanced approach to coral disease investigation is critical for understanding the global decline of corals. Such an approach should involve the proper use of biomedical concepts, tools, and terminology to address confusion and promote clarity in the coral disease literature. Investigating disease in corals should follow a logical series of steps including identification of disease, systematic morphologic descriptions of lesions at the gross and cellular levels, measurement of health indices, and experiments to understand disease pathogenesis and the complex interactions between host, pathogen, and the environment. This model for disease investigation is widely accepted in the medical, veterinary and invertebrate pathology disciplines. We present standard biomedical rationale behind the detection, description, and naming of diseases and offer examples of the application of Koch's postulates to elucidate the etiology of some infectious diseases. Basic epidemiologic concepts are introduced to help investigators think systematically about the cause(s) of complex diseases. A major goal of disease investigation in corals and other organisms is to gather data that will enable the establishment of standardized case definitions to distinguish among diseases. Concepts and facts amassed from empirical studies over the centuries by medical and veterinary pathologists have standardized disease investigation and are invaluable to coral researchers because of the robust comparisons they enable; examples of these are given throughout this paper. Arguments over whether coral diseases are caused by primary versus opportunistic pathogens reflect the lack of data available to prove or refute such hypotheses and emphasize the need for coral disease investigations that focus on: characterizing the normal microbiota and physiology of the healthy host; defining ecological interactions within the microbial community associated with the host; and investigating host immunity, host

  1. Childhood lead poisoning: the torturous path from science to policy

    OpenAIRE

    Bellinger, David C; Bellinger, Andrew M.

    2006-01-01

    The long history of lead poisoning provides many lessons about the process by which scientific knowledge is translated into public health policy. In the United States, lead was added to paint and to gasoline in enormous quantities long after medical evidence clearly showed that excessive lead exposure caused considerable morbidity in the population. This article discusses some of the factors that contributed to the slow pace of efforts to address this problem, including the ubiquity and magni...

  2. Is basic science disappearing from medicine? The decline of biomedical research in the medical literature.

    Science.gov (United States)

    Steinberg, Benjamin E; Goldenberg, Neil M; Fairn, Gregory D; Kuebler, Wolfgang M; Slutsky, Arthur S; Lee, Warren L

    2016-02-01

    Explosive growth in our understanding of genomics and molecular biology have fueled calls for the pursuit of personalized medicine, the notion of harnessing biologic variability to provide patient-specific care. This vision will necessitate a deep understanding of the underlying pathophysiology in each patient. Medical journals play a pivotal role in the education of trainees and clinicians, yet we suspected that the amount of basic science in the top medical journals has been in decline. We conducted an automated search strategy in PubMed to identify basic science articles and calculated the proportion of articles dealing with basic science in the highest impact journals for 8 different medical specialties from 1994 to 2013. We observed a steep decline (40-60%) in such articles over time in almost all of the journals examined. This rapid decline in basic science from medical journals is likely to affect practitioners' understanding of and interest in the basic mechanisms of disease and therapy. In this Life Sciences Forum, we discuss why this decline may be occurring and what it means for the future of science and medicine.

  3. Early Childhood: Follow My Lead: A Science Board Game.

    Science.gov (United States)

    Science and Children, 1985

    1985-01-01

    Two identical boards and sets of playing pieces can help teach science vocabulary while improving skills in observing, describing, giving clear and complete directions, and listening to and questioning those directions. Children or groups communicate without seeing each other's board. Examples of topics/board design and suggestions for teachers…

  4. Childhood lead poisoning: the torturous path from science to policy.

    Science.gov (United States)

    Bellinger, David C; Bellinger, Andrew M

    2006-04-01

    The long history of lead poisoning provides many lessons about the process by which scientific knowledge is translated into public health policy. In the United States, lead was added to paint and to gasoline in enormous quantities long after medical evidence clearly showed that excessive lead exposure caused considerable morbidity in the population. This article discusses some of the factors that contributed to the slow pace of efforts to address this problem, including the ubiquity and magnitude of lead exposure during much of the twentieth century, which produced a distorted notion about the blood lead level that can be considered "normal"; the prevailing model of disease during this period, notably the novelty of the concept of subclinical disease; the fact that childhood lead poisoning affected mostly families that were politically and economically disenfranchised, fostering a "blame the victim" attitude; and that controlling lead exposure would have impeded efforts to achieve other desirable goals, illustrating the role that value trade-offs often play in policy decisions.

  5. Using a popular science nonfiction book to introduce biomedical research ethics in a biology majors course.

    Science.gov (United States)

    Walton, Kristen L W

    2014-12-01

    Although bioethics is an important topic in modern society, it is not a required part of the curriculum for many biology degree programs in the United States. Students in our program are exposed to biologically relevant ethical issues informally in many classes, but we do not have a requirement for a separate bioethics course. The Immortal Life of Henrietta Lacks is a recent nonfiction book that describes the life of the woman whose cervical cancer biopsy gave rise to the HeLa cell line, as well as discussing relevant medical, societal, and ethical issues surrounding human tissue use for research. Weekly reading assignments from the book with discussion questions and a final paper were used to engage students in learning about the ethics of human subjects and human tissues research. Students were surveyed for qualitative feedback on the usefulness of including this book as part of the course. This book has been a successful platform for increasing student knowledge and interest in ethics related to biomedical and biological research.

  6. Using a Popular Science Nonfiction Book to Introduce Biomedical Research Ethics in a Biology Majors Course

    Directory of Open Access Journals (Sweden)

    Kristen L.W. Walton

    2014-08-01

    Full Text Available Although bioethics is an important topic in modern society, it is not a required part of the curriculum for many biology degree programs in the United States.  Students in our program are exposed to biologically relevant ethical issues informally in many classes, but we do not have a requirement for a separate bioethics course.  The Immortal Life of Henrietta Lacks is a recent nonfiction book that describes the life of the woman whose cervical cancer biopsy gave rise to the HeLa cell line, as well as discussing relevant medical, societal, and ethical issues surrounding human tissue use for research.  Weekly reading assignments from the book with discussion questions and a final paper were used to engage students in learning about the ethics of human subjects and human tissues research.  Students were surveyed for qualitative feedback on the usefulness of including this book as part of the course.  This book has been a successful platform for increasing student knowledge and interest in ethics related to biomedical and biological research.

  7. The reincarnation of a biomedical researcher: from bench science to medical education.

    Science.gov (United States)

    Brawer, James R

    2008-02-01

    After 33 years as a biomedical research scientist, I embarked on a new career in medical education. The transformation was awkward, difficult and exciting. Although I had assumed that previous experience in research and scholarship would stand me in good stead, such was hardly the case. I had to learn to navigate a strange new literature, replete with terms that I did not understand, and to deal with concepts that challenged my physico-chemical mindset. As I learned, I found myself discovering a field rich in essential questions, controversial hypotheses, and important potential applications. With my newly acquired knowledge and skills, I began to reflect on my own educational endeavors. I identified a number of outstanding issues and I designed studies to address them. What made these investigations particularly significant for me was their applicability. Although medical education is an exciting and meaningful career path, because of its low profile in most medical schools, few faculty are aware of the academic opportunities that it affords.

  8. Mentoring Strategies and Outcomes of Two Federally Funded Cancer Research Training Programs for Underrepresented Students in the Biomedical Sciences.

    Science.gov (United States)

    Ford, Marvella E; Abraham, Latecia M; Harrison, Anita L; Jefferson, Melanie S; Hazelton, Tonya R; Varner, Heidi; Cannady, Kimberly; Frichtel, Carla S; Bagasra, Omar; Davis, Leroy; Rivers, David E; Slaughter, Sabra C; Salley, Judith D

    2016-06-01

    The US is experiencing a severe shortage of underrepresented biomedical researchers. The purpose of this paper is to present two case examples of cancer research mentoring programs for underrepresented biomedical sciences students. The first case example is a National Institutes of Health/National Cancer Institute (NIH/NCI) P20 grant titled "South Carolina Cancer Disparities Research Center (SC CaDRe)" Training Program, contributing to an increase in the number of underrepresented students applying to graduate school by employing a triple-level mentoring strategy. Since 2011, three undergraduate and four graduate students have participated in the P20 SC CaDRe program. One graduate student published a peer-reviewed scientific paper. Two graduate students (50 %) have completed their master's degrees, and the other two graduate students will receive their degrees in spring 2015. Two undergraduate students (67 %) are enrolled in graduate or professional school (grad./prof. school), and the other graduate student is completing her final year of college. The second case example is a prostate cancer-focused Department of Defense grant titled "The SC Collaborative Undergraduate HBCU Student Summer Training Program," providing 24 students training since 2009. Additionally, 47 students made scientific presentations, and two students have published peer-reviewed scientific papers. All 24 students took a GRE test preparation course; 15 (63 %) have applied to graduate school, and 11 of them (73 %) are enrolled in grad./prof. school. Thirteen remaining students (54 %) are applying to grad./prof. school. Leveraged funding provided research-training opportunities to an additional 201 National Conference on Health Disparities Student Forum participants and to 937 Ernest E. Just Research Symposium participants at the Medical University of South Carolina.

  9. Tribute to a Leading Personality of World Horticultural Science

    OpenAIRE

    2010-01-01

    Following the proposal of Academic Council of Horticulture Faculty, the Senate of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca accepted nominee Professor Jules Janick for Doctor Honoris Causa award. The title was awarded in festive ceremony on September 30, 2010. Jules Janick, Professor at Purdue University has a long and distinguished career devoted to horticulture in all its facets. In horticultural research, he has made important advances including the gen...

  10. Identity Theft in the Academic World Leads to Junk Science.

    Science.gov (United States)

    Dadkhah, Mehdi; Lagzian, Mohammad; Borchardt, Glenn

    2017-01-10

    In recent years, identity theft has been growing in the academic world. Cybercriminals create fake profiles for prominent scientists in attempts to manipulate the review and publishing process. Without permission, some fraudulent journals use the names of standout researchers on their editorial boards in the effort to look legitimate. This opinion piece, highlights some of the usual types of identity theft and their role in spreading junk science. Some general guidelines that editors and researchers can use against such attacks are presented.

  11. Tribute to a Leading Personality of World Horticultural Science

    Directory of Open Access Journals (Sweden)

    Radu E. SESTRAS

    2010-12-01

    Full Text Available Following the proposal of Academic Council of Horticulture Faculty, the Senate of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca accepted nominee Professor Jules Janick for Doctor Honoris Causa award. The title was awarded in festive ceremony on September 30, 2010. Jules Janick, Professor at Purdue University has a long and distinguished career devoted to horticulture in all its facets. In horticultural research, he has made important advances including the genetics of sex determination including the synthesis of heteromorphic sex chromosomes, fireblight resistance, cleistogamy, cucurbitacins, artemisisin production, anthocyanin pigmentation, as well as in vitro metabolite production from somatic embryos and the production of synthetic seed. In crop improvement, he has been associated with the release of 21 scab-resistant apple cultivars, three pear cultivars with tolerance to fireblight, delayed-bolting arugula, crack resistant tomato, and the first release of a pelargonium cultivar from somaclonal variation. Professor Janick has made contributions to the historical aspects of horticulture and explored the relation of art and horticultural technology with special studies on the iconography of Rubus, Cucurbitaceae, and Solanaceae, opening up a new approach to the study of plant diversity, origins, cultivar evolution, and diversity. Professor Janick has been a prolific author and editor in horticulture. He was the editor of HortScience and editor of the Journal of ASHS. He is the founder and editor of both Horticultural Reviews and Plant Breeding Reviews. Since 2002 he has been the science editor of Chronica Horticulturae (ISHS. Janick has edited and produced six proceedings of New Crops symposia since 1990 that have had a deep impact on new crop information. The development of a new crop website has become a major world resource for information on crops. He is the author of the texts Horticultural Science, Plant Science

  12. Beyond Preparation: Identity, Cultural Capital, and Readiness for Graduate School in the Biomedical Sciences

    Science.gov (United States)

    Gazley, J. Lynn; Remich, Robin; Naffziger-Hirsch, Michelle E.; Keller, Jill; Campbell, Patricia B.; McGee, Richard

    2014-01-01

    In this study, we conducted in-depth interviews with 52 college graduates as they entered a Postbaccalaureate Research Education Program (PREP). Our goal was to investigate what it means for these aspiring scientists, most of whom are from groups underrepresented in the sciences, to feel ready to apply to a doctoral program in the biomedical…

  13. 77 FR 20489 - Joint Biomedical Laboratory Research and Development and Clinical Science Research and...

    Science.gov (United States)

    2012-04-04

    ... Town Alexandria. Cellular and Molecular June 4, 2012..... *VA Central Office. Medicine. Infectious... May 24, 2012..... Sheraton Suites--Old Science-B. Town Alexandria. Neurobiology-D May 24-25, 2012.... Neurobiology-A June 1, 2012..... Sheraton Suites--Old Town Alexandria. Clinical Application of June 1,...

  14. Making Bioinformatics Projects a Meaningful Experience in an Undergraduate Biotechnology or Biomedical Science Programme

    Science.gov (United States)

    Sutcliffe, Iain C.; Cummings, Stephen P.

    2007-01-01

    Bioinformatics has emerged as an important discipline within the biological sciences that allows scientists to decipher and manage the vast quantities of data (such as genome sequences) that are now available. Consequently, there is an obvious need to provide graduates in biosciences with generic, transferable skills in bioinformatics. We present…

  15. Subject Design and Factors Affecting Achievement in Mathematics for Biomedical Science

    Science.gov (United States)

    Carnie, Steven; Morphett, Anthony

    2017-01-01

    Reports such as Bio2010 emphasize the importance of integrating mathematical modelling skills into undergraduate biology and life science programmes, to ensure students have the skills and knowledge needed for biological research in the twenty-first century. One way to do this is by developing a dedicated mathematics subject to teach modelling and…

  16. [A study of development of medicine and science in the nineteenth century science fiction: biomedical experiments in Mary Shelley's Frankenstein].

    Science.gov (United States)

    Choo, Jae-Uk

    2014-12-01

    As the sciences advanced rapidly in the modern European world, outstanding achievements have been made in medicine, chemistry, biology, physiology, physics and others, which have been co-influencing each of the scientific disciplines. Accordingly, such medical and scientific phenomena began to be reflected in novels. In particular, Mary Shelley's Frankenstein includes the diverse aspects of the change and development in the medicine and science. Associated with medical and scientific information reflected in Frankenstein and Frankenstein's experiments in the text, accordingly, this research will investigate the aspects of medical and scientific development taking place in the nineteenth century in three ways. First, the medical and scientific development of the nineteenth century has been reviewed by summerizing both the information of alchemy in which Frankenstein shows his interest and the new science in general that M. Waldman introduces in the text. Second, the actual features of medical and scientific development have been examined through some examples of the experimental methods that M. Waldman implicitly uttered to Frankenstein. Third, it has been checked how the medical and scientific development is related to the main issues of mechanism and vitalism which can be explained as principles of life. Even though this research deals with the developmental process of medicine & science and origin & principles of life implied in Mary Shelley's Frankenstein, its significance is that it is the interdisciplinary research focussing on how deeply medical and scientific discourse of Mary Shelley's period has been imbedded in the nineteenth century novel.

  17. Healthcare and biomedical technology in the 21st century an introduction for non-science majors

    CERN Document Server

    Baran, George R; Samuel, Solomon Praveen

    2014-01-01

    This textbook introduces students not pursuing degrees in science or engineering to the remarkable new applications of technology now available to physicians and their patients and discusses how these technologies are evolving to permit new treatments and procedures.  The book also elucidates the societal and ethical impacts of advances in medical technology, such as extending life and end of life decisions, the role of genetic testing, confidentiality, costs of health care delivery, scrutiny of scientific claims, and provides background on the engineering approach in healthcare and the scientific method as a guiding principle. This concise, highly relevant text enables faculty to offer a substantive course for students from non-scientific backgrounds that will empower them to make more informed decisions about their healthcare by significantly enhancing their understanding of these technological advancements. This book also: ·         Presents scientific concepts from modern medical science using r...

  18. Handbook of Coherent-Domain Optical Methods Biomedical Diagnostics, Environmental Monitoring, and Materials Science

    CERN Document Server

    2013-01-01

    This Handbook provides comprehensive coverage of laser and coherent-domain methods as applied to biomedicine, environmental monitoring, and materials science. Worldwide leaders in these fields describe the fundamentals of light interaction with random media and present an overview of basic research. The latest results on coherent and polarization properties of light scattered by random media, including tissues and blood, speckles formation in multiple scattering media, and other non-destructive interactions of coherent light with rough surfaces and tissues, allow the reader to understand the principles and applications of coherent diagnostic techniques. The expanded second edition has been thoroughly updated with particular emphasis on novel coherent-domain techniques and their applications in medicine and environmental science. Volume 1 describes state-of-the-art methods of coherent and polarization optical imaging, tomography and spectroscopy; diffusion wave spectroscopy; elastic, quasi-elastic and inelasti...

  19. Some Aspects of the State-of-the-Arts in Biomedical Science Research: A Perspective for Organizational Change in African Academia.

    Science.gov (United States)

    John, Theresa Adebola

    2014-01-01

    In the biomedical sciences, there is need to generate solutions for Africa's health and economic problems through the impact of university research. To guide organizational transformation, the author here presents some aspects of the state-of-the-arts of biomedical science research in advanced countries using a perspective derived from the FASEB journal publications. The author examines the thirty three peer reviewed scientific research articles in a centennial (April 2012) issue of the FASEB Journal [Volume 26(4)] using the following parameters: number of authors contributing to the paper; number of academic departments contributing to the paper; number of academic institutions contributing to the paper; funding of the research reported in the article. The articles were written by 7.97±0.61 authors from 3.46±0.3 departments of 2.79±0.29 institutions. The contributors were classified into four categories: basic sciences, clinical sciences, institutions and centers, and programs and labs. Amongst the publications, 21.2% were single disciplinary. Two tier collaboration amongst any two of the four categories were observed in 16/33 (48.5%) of the articles. Three tier and four tier collaborations were observed amongst 7/33 (21.2%) and 3/33 (9%) of the articles respectively. Therefore 26/33 (78.7%) of the articles were multidisciplinary. Collaborative efforts between basic science and clinical science departments were observed in 9/33 (27.3%) articles. Public funding through government agencies provided 85 out of a total of 143 (59.5%) grants. The collaborative and multidisciplinary nature and government support are characteristic of biomedical science in the US where research tends to result in solutions to problems and economic benefits.

  20. The importance of being elegant: a discussion of elegance in nephrology and biomedical science.

    Science.gov (United States)

    Nathan, Marco J; Brancaccio, Diego

    2013-06-01

    Elegance is pursued and appreciated in virtually all aspects of our lives, from fashion to visual and performing arts, from literature to architecture. While most of us praise the elegance and beauty of science when we see it, elegance is typically treated as something that need not concern our research and thus does not belong inside the laboratory. In this article, we provide an alternative perspective, according to which elegance is more than an accessory ornament of scientific theories. We endorse and defend the view that elegance is an intrinsic feature of successful scientific practice and observation, a benchmark that demarcates between good experiments and bad ones. In support of our conclusions, we present and discuss three paradigms of scientific elegance: Jenner's discovery of vaccination, Bricker and Slatopolsky's trade-off hypothesis and Brenner's hypothesis regarding the role of residual nephrons in the decline of renal function.

  1. Career Coaches as a Source of Vicarious Learning for Racial and Ethnic Minority PhD Students in the Biomedical Sciences: A Qualitative Study

    Science.gov (United States)

    Williams, Simon N.; Thakore, Bhoomi K.; McGee, Richard

    2016-01-01

    Introduction Many recent mentoring initiatives have sought to help improve the proportion of underrepresented racial and ethnic minorities (URMs) in academic positions across the biomedical sciences. However, the intractable nature of the problem of underrepresentation suggests that many young scientists may require supplemental career development beyond what many mentors are able to offer. As an adjunct to traditional scientific mentoring, we created a novel academic career “coaching” intervention for PhD students in the biomedical sciences. Objective To determine whether and how academic career coaches can provide effective career-development-related learning experiences for URM PhD students in the biomedical sciences. We focus specifically on vicarious learning experiences, where individuals learn indirectly through the experiences of others. Method The intervention is being tested as part of a longitudinal randomized control trial (RCT). Here, we describe a nested qualitative study, using a framework approach to analyze data from a total of 48 semi-structured interviews from 24 URM PhD students (2 interviews per participant, 1 at baseline, 1 at 12-month follow-up) (16 female, 8 male; 11 Black, 12 Hispanic, 1 Native-American). We explored the role of the coach as a source of vicarious learning, in relation to the students’ goal of being future biomedical science faculty. Results Coaches were resources through which most students in the study were able to learn vicariously about how to pursue, and succeed within, an academic career. Coaches were particularly useful in instances where students’ research mentors are unable to provide such vicarious learning opportunities, for example because the mentor is too busy to have career-related discussions with a student, or because they have, or value, a different type of academic career to the type the student hopes to achieve. Implications Coaching can be an important way to address the lack of structured career

  2. 75 FR 69078 - Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA)

    Science.gov (United States)

    2010-11-10

    ... AGENCY Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA) AGENCY... a workshop to evaluate initial draft materials for the Pb Integrated Science Assessment (ISA) is... the scientific content of initial draft materials or sections for the draft ISA. Workshop...

  3. Web of Science, Scopus, and Google Scholar citation rates: a case study of medical physics and biomedical engineering: what gets cited and what doesn't?

    Science.gov (United States)

    Trapp, Jamie

    2016-12-01

    There are often differences in a publication's citation count, depending on the database accessed. Here, aspects of citation counts for medical physics and biomedical engineering papers are studied using papers published in the journal Australasian physical and engineering sciences in medicine. Comparison is made between the Web of Science, Scopus, and Google Scholar. Papers are categorised into subject matter, and citation trends are examined. It is shown that review papers as a group tend to receive more citations on average; however the highest cited individual papers are more likely to be research papers.

  4. Why not just Google it? An assessment of information literacy skills in a biomedical science curriculum

    Science.gov (United States)

    2011-01-01

    Background Few issues in higher education are as fundamental as the ability to search for, evaluate, and synthesize information. The need to develop information literacy, the process of finding, retrieving, organizing, and evaluating the ever-expanding collection of online information, has precipitated the need for training in skill-based competencies in higher education, as well as medical and dental education. Methods The current study evaluated the information literacy skills of first-year dental students, consisting of two, consecutive dental student cohorts (n = 160). An assignment designed to evaluate information literacy skills was conducted. In addition, a survey of student online search engine or database preferences was conducted to identify any significant associations. Subsequently, an intervention was developed, based upon the results of the assessment and survey, to address any deficiencies in information literacy. Results Nearly half of students (n = 70/160 or 43%) missed one or more question components that required finding an evidence-based citation. Analysis of the survey revealed a significantly higher percentage of students who provided incorrect responses (n = 53/70 or 75.7%) reported using Google as their preferred online search method (p < 0.01). In contrast, a significantly higher percentage of students who reported using PubMed (n = 39/45 or 86.7%) were able to provide correct responses (p < 0.01). Following a one-hour intervention by a health science librarian, virtually all students were able to find and retrieve evidence-based materials for subsequent coursework. Conclusions This study confirmed that information literacy among this student population was lacking and that integration of modules within the curriculum can help students to filter and establish the quality of online information, a critical component in the training of new health care professionals. Furthermore, incorporation of these modules early in the curriculum may be of

  5. Leading the way in biomedical engineering: an interview with Robert Langer. Interview by Hannah Stanwix, Commissioning Editor.

    Science.gov (United States)

    Langer, Robert

    2012-10-01

    Professor Robert Langer obtained his Bachelor's Degree in Chemical Engineering from Cornell University (NY, USA) in 1970. He received his Sc.D. from the Massachusetts Institute of Technology (MA, USA) in 1974. He is currently the David H Koch Institute Professor at the Massachusetts Institute of Technology. Professor Langer is a member of the Institute of Medicine of the National Academy of Sciences, the National Academy of Engineering and the National Academy of Sciences. At the age of 43 he was the youngest person in history to be elected to all three United States National Academies. Throughout his career, Professor Langer has received over 200 awards including, notably, the Charles Stark Draper Prize (considered the equivalent of the Nobel Prize for engineers), the 2008 Millennium Prize, the 2006 United States National Medal of Science and the 2012 Priestley Medal. In 1996 he was awarded the Gairdner Foundation International Award (the only engineer ever to have been awarded this accolade). Professor Langer has also been the recipient of the Lemelson-MIT prize, which he was awarded with for being "one of history's most prolific inventors in medicine." Professor Langer was selected by Time Magazine in 2001 as one of the 100 most important people in the USA. He has received honorary degrees from several universities worldwide, including Harvard University (MA, USA), the Mt. Sinai School of Medicine (NY, USA), Yale University (CT, USA), the ETH Zurich (Zurich, Switzerland), the Technion-Israel Institute of Technology (Haifa, Israel), the Hebrew University of Jerusalem (Israel), the Université Catholique de Louvain (Louvain-La-Neuve, Belgium), Rensselaer Polytechnic Institute (NY, USA), Willamette University (OR, USA), the University of Liverpool (Liverpool, UK), Bates College (ME, USA), the University of Nottingham (Nottingham, UK), Albany Medical College (NY, USA), Pennsylvania State University (PA, USA), Northwestern University (IL, USA) and Uppsala University

  6. Lead

    Science.gov (United States)

    ... found? Who is at risk? What are the health effects of lead? Get educational material about lead Get certified as a Lead Abatement Worker, or other abatement discipline Lead in drinking water Lead air pollution Test your child Check and maintain your home ...

  7. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D; Bronzino, Joseph D

    2006-01-01

    Over the last century,medicine has come out of the "black bag" and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiology to informatics and signal processing. Reflecting the enormous growth and change in biomedical engineering during the infancy of the 21st century, The Biomedical Engineering Handbook enters its third edition as a set of three carefully focused and

  8. Pacific Northwest Laboratory annual report for 1983 to the DOE Office of Energy Research. Part 1. Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1984-02-01

    This report summarizes progress on Office of Health and Environmental Research (OHER) biomedical and health effects research conducted at PNL in FY 1983 to develop the information required for a comprehensive understanding of the interaction of energy-related pollutants with living organisms. The first section is devoted to an evaluation of possible health effects among nuclear workers. The next three sections, which contain reports of health effects research in biological systems, are grouped according to the major endpoint being studied: carcinogenesis, mutagenesis, and systems damage. Since some projects have multiple objectives, a section may contain data concerning other endpoints as well. The section on carcinogenesis presents results from laboratory animal dose-effect relationship studies from both nuclear and synfuels materials. These data, along with metabolism and modeling studies, provide a basis for predicting human risks in the absence of relevant human exposure. This year we include a report on our 22nd Hanford Life Sciences Symposium, which dealt with this problem of extrapolating the results of animal studies to man. Of particular importance in carcinogenesis has been the demonstration that the carcinogenic potencies of complex organic synfuel mixtures may be much lower (or, occasionally, higher) than the sum of the potencies of the individual components. The mutagenesis section is primarily concerned with the results of microbial mutagenesis studies with synfuel materials. These studies provide valuable information on the carcinogenic potential of these complex organic mixtures. With results from studies reported in the carcinogenesis section, they are also being used to establish an adequate data base for determining the correlation between mutagenic and carcinogenic processes. Separate abstracts have been prepared for each program for inclusion in the Energy Data Base.

  9. "Partners in Science": A Model Cooperative Program Introducing High School Teachers and Students to Leading-Edge Pharmaceutical Science

    Science.gov (United States)

    Woska, Joseph R., Jr.; Collins, Danielle M.; Canney, Brian J.; Arcario, Erin L.; Reilly, Patricia L.

    2005-01-01

    "Partners in Science" is a cooperative program between Boehringer Ingelheim Pharmaceuticals, Inc. and area high schools in the community surrounding our Connecticut campus. It is a two-phase program that introduces high school students and teachers to the world of drug discovery and leading-edge pharmaceutical research. Phase 1 involves…

  10. Biomedical Engineering Desk Reference

    CERN Document Server

    Ratner, Buddy D; Schoen, Frederick J; Lemons, Jack E; Dyro, Joseph; Martinsen, Orjan G; Kyle, Richard; Preim, Bernhard; Bartz, Dirk; Grimnes, Sverre; Vallero, Daniel; Semmlow, John; Murray, W Bosseau; Perez, Reinaldo; Bankman, Isaac; Dunn, Stanley; Ikada, Yoshito; Moghe, Prabhas V; Constantinides, Alkis

    2009-01-01

    A one-stop Desk Reference, for Biomedical Engineers involved in the ever expanding and very fast moving area; this is a book that will not gather dust on the shelf. It brings together the essential professional reference content from leading international contributors in the biomedical engineering field. Material covers a broad range of topics including: Biomechanics and Biomaterials; Tissue Engineering; and Biosignal Processing* A hard-working desk reference providing all the essential material needed by biomedical and clinical engineers on a day-to-day basis * Fundamentals, key techniques,

  11. NIH Funding for Biomedical Imaging

    Science.gov (United States)

    Conroy, Richard

    Biomedical imaging, and in particular MRI and CT, is often identified as among the top 10 most significant advances in healthcare in the 20th century. This presentation will describe some of the recent advances in medical physics and imaging being funded by NIH in this century and current funding opportunities. The presentation will also highlight the role of multidisciplinary research in bringing concepts from the physical sciences and applying them to challenges in biological and biomedical research.. NIH Funding for Biomedical Imaging.

  12. Pacific Northwest Laboratory annual report for 1983 to the DOE Office of Energy Research. Part 1. Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Drucker, H.

    1983-02-01

    Biomedical and health effects research conducted at PNL in 1982 on the evaluation of risk to man from existing and/or developing energy-related technologies are described. Most of the studies described in this report relate to activities for three major energy technologies: nuclear fuel cycle; fossil fuel cycle (oil, gas, and coal process technologies, mining, and utilization; synfuel development), and fudion (biomagnetic effects). The report is organized under these technologies. In addition, research reports are included on the application of nuclear energy to biomedical problems. Individual projects are indexed separately.

  13. Biomedical engineering frontier research and converging technologies

    CERN Document Server

    Jun, Ho-Wook; Shin, Jennifer; Lee, SangHoon

    2016-01-01

    This book provides readers with an integrative overview of the latest research and developments in the broad field of biomedical engineering. Each of the chapters offers a timely review written by leading biomedical engineers and aims at showing how the convergence of scientific and engineering fields with medicine has created a new basis for practically solving problems concerning human health, wellbeing and disease. While some of the latest frontiers of biomedicine, such as neuroscience and regenerative medicine, are becoming increasingly dependent on new ideas and tools from other disciplines, the paradigm shift caused by technological innovations in the fields of information science, nanotechnology, and robotics is opening new opportunities in healthcare, besides dramatically changing the ways we actually practice science. At the same time, a new generation of engineers, fluent in many different scientific “languages,” is creating entirely new fields of research that approach the “old” questions f...

  14. Molecular Biomedical Imaging Laboratory (MBIL)

    Data.gov (United States)

    Federal Laboratory Consortium — The Molecular Biomedical Imaging Laboratory (MBIL) is adjacent-a nd has access-to the Department of Radiology and Imaging Sciences clinical imaging facilities. MBIL...

  15. What is biomedical informatics?

    Science.gov (United States)

    Bernstam, Elmer V; Smith, Jack W; Johnson, Todd R

    2010-02-01

    Biomedical informatics lacks a clear and theoretically-grounded definition. Many proposed definitions focus on data, information, and knowledge, but do not provide an adequate definition of these terms. Leveraging insights from the philosophy of information, we define informatics as the science of information, where information is data plus meaning. Biomedical informatics is the science of information as applied to or studied in the context of biomedicine. Defining the object of study of informatics as data plus meaning clearly distinguishes the field from related fields, such as computer science, statistics and biomedicine, which have different objects of study. The emphasis on data plus meaning also suggests that biomedical informatics problems tend to be difficult when they deal with concepts that are hard to capture using formal, computational definitions. In other words, problems where meaning must be considered are more difficult than problems where manipulating data without regard for meaning is sufficient. Furthermore, the definition implies that informatics research, teaching, and service should focus on biomedical information as data plus meaning rather than only computer applications in biomedicine.

  16. On Biomedical Research Policy in the Future

    Science.gov (United States)

    1989-01-01

    0 ON BIOMEDICAL RESEARCH POLICY IN THE FUTURE Albert P. Williams January 1989 DTIC ELECTE P-7520 "’T,, . The RAND Corporation Papers are issued by...BIOMEDICAL RESEARCH POLICY IN THE FUTURE[l] Mr. Walden, members of the Science Policy Task Force, I am honored to be invited to appear on this panel and...to offer my thoughts on future biomedical research policy . My perspective is that of an outsider with a longstanding interest in federal biomedical

  17. Pacific Northwest Laboratory annual report for 1980 to the DOE Assistant Secretary for Environment. Part 1. Biomedical sciences. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Drucker, H.

    1981-02-01

    Separate abstracts were prepared for 31 sections in this progress report. The appendix which deals with dose-effect studies with inhaled plutonium in beagles is not represented by a separate abstract. (KRM)

  18. Linking geology and health sciences to assess childhood lead poisoning from artisanal gold mining in Nigeria

    Science.gov (United States)

    Plumlee, Geoffrey S.; Durant, James T.; Morman, Suzette A.; Neri, Antonio; Wolf, Ruth E.; Dooyema, Carrie A.; Hageman, Philip L.; Lowers, Heather; Fernette, Gregory L.; Meeker, Gregory P.; Benzel, William M.; Driscoll, Rhonda L.; Berry, Cyrus J.; Crock, James G.; Goldstein, Harland L.; Adams, Monique; Bartrem, Casey L.; Tirima, Simba; Behrooz, Behbod; von Lindern, Ian; Brown, Mary Jean

    2013-01-01

    Background: In 2010, Médecins Sans Frontières discovered a lead poisoning outbreak linked to artisanal gold processing in northwestern Nigeria. The outbreak has killed approximately 400 young children and affected thousands more. Objectives: Our aim was to undertake an interdisciplinary geological- and health-science assessment to clarify lead sources and exposure pathways, identify additional toxicants of concern and populations at risk, and examine potential for similar lead poisoning globally. Methods: We applied diverse analytical methods to ore samples, soil and sweep samples from villages and family compounds, and plant foodstuff samples. Results: Natural weathering of lead-rich gold ores before mining formed abundant, highly gastric-bioaccessible lead carbonates. The same fingerprint of lead minerals found in all sample types confirms that ore processing caused extreme contamination, with up to 185,000 ppm lead in soils/sweep samples and up to 145 ppm lead in plant foodstuffs. Incidental ingestion of soils via hand-to-mouth transmission and of dusts cleared from the respiratory tract is the dominant exposure pathway. Consumption of water and foodstuffs contaminated by the processing is likely lesser, but these are still significant exposure pathways. Although young children suffered the most immediate and severe consequences, results indicate that older children, adult workers, pregnant women, and breastfed infants are also at risk for lead poisoning. Mercury, arsenic, manganese, antimony, and crystalline silica exposures pose additional health threats. Conclusions: Results inform ongoing efforts in Nigeria to assess lead contamination and poisoning, treat victims, mitigate exposures, and remediate contamination. Ore deposit geology, pre-mining weathering, and burgeoning artisanal mining may combine to cause similar lead poisoning disasters elsewhere globally.

  19. A community of practice: librarians in a biomedical research network.

    Science.gov (United States)

    De Jager-Loftus, Danielle P; Midyette, J David; Harvey, Barbara

    2014-01-01

    Providing library and reference services within a biomedical research community presents special challenges for librarians, especially those in historically lower-funded states. These challenges can include understanding needs, defining and communicating the library's role, building relationships, and developing and maintaining general and subject specific knowledge. This article describes a biomedical research network and the work of health sciences librarians at the lead intensive research institution with librarians from primarily undergraduate institutions and tribal colleges. Applying the concept of a community of practice to a collaborative effort suggests how librarians can work together to provide effective reference services to researchers in biomedicine.

  20. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1973-01-01

    Advances in Biomedical Engineering, Volume 2, is a collection of papers that discusses the basic sciences, the applied sciences of engineering, the medical sciences, and the delivery of health services. One paper discusses the models of adrenal cortical control, including the secretion and metabolism of cortisol (the controlled process), as well as the initiation and modulation of secretion of ACTH (the controller). Another paper discusses hospital computer systems-application problems, objective evaluation of technology, and multiple pathways for future hospital computer applications. The pos

  1. Biomedical photonics handbook biomedical diagnostics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, studen

  2. Green fluorescent protein purification through Immobilized Metal Affinity Chromatografy (IMAC and its relevance for Biomedical Science students during Biochemistry practical classes at La Trobe University – Australia

    Directory of Open Access Journals (Sweden)

    Alex Jose José de Melo Silva

    2016-12-01

    Full Text Available This work was performed as an integrated practical of a Biomedical Science undergraduate course of Biochemistry subject, in order to demonstrate used techniques to purify of Green Fluorescent Protein (GFP. To perform the experiments the main methodology applied was the by immobilized metal affinity chromatography (IMAC.  The open reading frame for enhanced GFP was sub-cloned into the pQE30 expression vector. The subsequent production of protein tagged N-terminally with hexahistidine, facilitated its purification by IMAC.  An approximate 3-fold purification of GFP was achieved. Thus, the students who completed the course gained significant experience related to fundamental techniques in molecular cloning and a sound basis in the principles of recombinant protein expression and purification.

  3. Los Alamos Life Sciences Division's biomedical and environmental research programs. Progress report, January-December 1980

    Energy Technology Data Exchange (ETDEWEB)

    Holland, L.M.; Stafford, C.G.; Bolen, S.K. (comps.)

    1981-09-01

    Highlights of research progress accomplished in the Life Sciences Division during the year ending December 1980 are summarized. Reports from the following groups are included: Toxicology, Biophysics, Genetics; Environmental Pathology, Organic Chemistry, and Environmental Sciences. Individual abstracts have been prepared for 46 items for inclusion in the Energy Data Base. (RJC)

  4. The Rosetta Stone of isotope science and the uranium/lead system.

    Science.gov (United States)

    De Laeter, John

    2011-01-01

    The nucleosynthetic characteristics of U and Pb, together with the interconnectivity between these elements by two radioactive decay chains, are the foundation on which the U/Pb system was able to make a unique contribution to isotope science. The Rosetta Stone is an ancient Egyptian tablet that enabled previously indecipherable hieroglyphics to be translated. In a similar manner, the isotopic investigation of the U/Pb system, by a variety of mass spectrometric instrumentation, has led to our knowledge of the age of the Earth and contributed to thermochronology. In a similar manner, climate change information has been garnered by utilizing the U-Disequilibrium Series to measure the ages of marine archives. The impact of Pb in the environment has been demonstrated in human health, particularly at the peak of leaded petrol consumption in motor vehicles in the 1970s. Variations in the isotopic composition of lead in samples enable the source of the lead to be "fingerprinted" so as to trace the history of the Pb in ice cores and aerosols. The discovery of nuclear fission of (235)U led to the development of nuclear reactors and the isotopic investigation of the Oklo natural reactors. The mass spectrometer is the modern Rosetta Stone of isotope science, which has enabled the isotopic hieroglyphics of the U/Pb system to be investigated to reveal new horizons in our understanding of nature, and to address a number of societal and environmental problems.

  5. Pacific Northwest Laboratory annual report for 1985 to the DOE Office of Energy Research. Part 1. Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1986-02-01

    This report summarizes progress on OHER biomedical and health-effects research conducted at PNL in FY 1985 to develop information for a comprehensive understanding of the interaction of energy-related radiation and chemicals with man. Our continuing emphasis on decreasing the uncertainty of health-effects risk estimates to man from existing and/or developing energy-related technologies supports the DOE goal of increasing and diversifying national energy resources and decreasing risks to human health. The report is arranged to reflect the PNL research relative to OHER programmatic needs. The first section concerns evaluation of possible health effects among nuclear workers. The next two sections, which contain reports of health-effects research in biological systems, include health effects of radiation and health effects of chemical mixtures. The last section is related to medical applications of nuclear technology.

  6. Pacific Northwest Laboratory: Annual report for 1986 to the DOE Office of Energy Research: Part 1, Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1987-02-01

    This report summarizes progress on OHER biomedical and health-effects research conducted at PNL in FY 1986. The research develops the knowledge and scientific principles necessary to identify, understand and anticipate the long-term health consequences of energy-related radiation and chemicals. Our continuing emphasis is to decrease the uncertainty of health-effects risk estimates from existing and/or developing energy-related technologies through an increased understanding of how radiation and chemicals cause health effects. The report is arranged to reflect the PNL research relative to OHER programmatic structure. The first section, on human health effects, concerns statistical and epidemiological methods for assessing health risks among nuclear workers. The next two sections, which contain reports of health-effects research in biological systems, include effects of radiation and of energy-related chemicals. The last section is related to medical applications of nuclear technology.

  7. Pacific Northwest Laboratory annual report for 1988 to the DOE Office of Energy Research: Part 1, Biomedical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1989-06-01

    This report summarizes progress on OHER biomedical and health-effects research conducted at PNL in FY 1988. The research develops the knowledge and scientific principles necessary to identify, understand, and anticipate the long-term health consequences of energy-related radiation and chemicals. Our continuing emphasis is to decrease the uncertainty of health-effects risk estimates from existing and/or developing energy-related technologies through an increased understanding of how radiation and chemicals cause health effects. The report is arranged to reflect PNL research relative to OHER programmatic structure. The first section, on human health effects, concerns statistical and epidemiological studies for assessing health risks. The next section, which contains reports of health-effects research in biological systems, includes research with radiation and chemicals.

  8. Pacific Northwest Laboratory annual report for 1987 to the DOE Office of Energy Research: Part 1, Biomedical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1988-02-01

    This report summarizes progress on OHER biomedical and health-effects research conducted at Pacific Northwest Laboratory in FY 1987. The research develops the knowledge and scientific principles necessary to identify, understand, and anticipate the long-term health consequences of energy-related radiation and chemicals. Our continuing emphasis is to decrease the uncertainty of health-effects risk estimates from existing and/or developing energy-related technologies through an increased understanding of how radiation and chemicals cause health effects. The report is arranged to reflect PNL research relative to OHER programmatic structure. The first section, on human health effects, concerns statistical and epidemiological studies for assessing health risks. The next section, which contains reports of health-effects research in biological systems, includes research with radiation and chemicals. The last section is related to medical applications of nuclear technology.

  9. Medicine's perception of reality - a split picture: critical reflections on apparent anomalies within the biomedical theory of science.

    Science.gov (United States)

    Kirkengen, Anna Luise; Ekeland, Tor-Johan; Getz, Linn; Hetlevik, Irene; Schei, Edvin; Ulvestad, Elling; Vetlesen, Arne Johan

    2016-08-01

    Escalating costs, increasing multi-morbidity, medically unexplained health problems, complex risk, poly-pharmacy and antibiotic resistance can be regarded as artefacts of the traditional knowledge production in Western medicine, arising from its particular worldview. Our paper presents a historically grounded critical analysis of this view. The materialistic shift of Enlightenment philosophy, separating subjectivity from bodily matter, became normative for modern medicine and yielded astonishing results. The traditional dichotomies of mind/body and subjective/objective are, however, incompatible with modern biological theory. Medical knowledge ignores central tenets of human existence, notably the physiological impact of subjective experience, relationships, history and sociocultural contexts. Biomedicine will not succeed in resolving today's poorly understood health problems by doing 'more of the same'. We must acknowledge that health, sickness and bodily functioning are interwoven with human meaning-production, fundamentally personal and biographical. This implies that the biomedical framework, although having engendered 'success stories' like the era of antibiotics, needs to be radically revised.

  10. Biomedical nanotechnology.

    Science.gov (United States)

    Hurst, Sarah J

    2011-01-01

    This chapter summarizes the roles of nanomaterials in biomedical applications, focusing on those highlighted in this volume. A brief history of nanoscience and technology and a general introduction to the field are presented. Then, the chemical and physical properties of nanostructures that make them ideal for use in biomedical applications are highlighted. Examples of common applications, including sensing, imaging, and therapeutics, are given. Finally, the challenges associated with translating this field from the research laboratory to the clinic setting, in terms of the larger societal implications, are discussed.

  11. Biomedical Libraries

    Science.gov (United States)

    Pizer, Irwin H.

    1978-01-01

    Biomedical libraries are discussed as a distinct and specialized group of special libraries and their unique services and user interactions are described. The move toward professional standards, as evidenced by the Medical Library Association's new certification program, and the current state of development for a new section of IFLA established…

  12. Biomedical photonics handbook

    CERN Document Server

    Vo-Dinh, Tuan

    2003-01-01

    1.Biomedical Photonics: A Revolution at the Interface of Science and Technology, T. Vo-DinhPHOTONICS AND TISSUE OPTICS2.Optical Properties of Tissues, J. Mobley and T. Vo-Dinh3.Light-Tissue Interactions, V.V. Tuchin 4.Theoretical Models and Algorithms in Optical Diffusion Tomography, S.J. Norton and T. Vo-DinhPHOTONIC DEVICES5.Laser Light in Biomedicine and the Life Sciences: From the Present to the Future, V.S. Letokhov6.Basic Instrumentation in Photonics, T. Vo-Dinh7.Optical Fibers and Waveguides for Medical Applications, I. Gannot and

  13. Using a Popular Science Nonfiction Book to Introduce Biomedical Research Ethics in a Biology Majors Course †

    Science.gov (United States)

    Walton, Kristen L. W.

    2014-01-01

    Although bioethics is an important topic in modern society, it is not a required part of the curriculum for many biology degree programs in the United States. Students in our program are exposed to biologically relevant ethical issues informally in many classes, but we do not have a requirement for a separate bioethics course. The Immortal Life of Henrietta Lacks is a recent nonfiction book that describes the life of the woman whose cervical cancer biopsy gave rise to the HeLa cell line, as well as discussing relevant medical, societal, and ethical issues surrounding human tissue use for research. Weekly reading assignments from the book with discussion questions and a final paper were used to engage students in learning about the ethics of human subjects and human tissues research. Students were surveyed for qualitative feedback on the usefulness of including this book as part of the course. This book has been a successful platform for increasing student knowledge and interest in ethics related to biomedical and biological research. PMID:25574289

  14. Pacific Northwest Laboratory annual report for 1993 to the DOE Office of Energy Research. Part 1: Biomedical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Lumetta, C.C. [ed.; Park, J.F.

    1994-03-01

    This report summarizes FY 1993 progress in biological and general life sciences research programs conducted for the Department of Energy`s Office of Health and Environmental REsearch (OHER) at Pacific Northwest Laboratory (PNL). This research provides knowledge of fundamental principles necessary to identify, understand, and anticipate the long-term health consequences of exposure to energy-related radiation and chemicals. The Biological Research section contains reports of studies using laboratory animals, in vitro cell systems, and molecular biological systems. This research includes studies of the impact of radiation, radionuclides, and chemicals on biological responses at all levels of biological organization. The General Life Sciences Research section reports research conducted for the OHER human genome program.

  15. Pacific Northwest Laboratory annual report for 1991 to the DOE Office of Energy Research. Part 1, Biomedical sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1992-09-01

    This report summarizes progress in OHER biological research and general life sciences research programs conducted conducted at PNL in FLY 1991. The research develops the knowledge and scientific principles necessary to identify, understand, and anticipate the long- term health consequences of energy-related radiation and chemicals. Our continuing emphasis is to decrease the uncertainty of health risk estimates from existing and newly developed energy-related technologies through an increased understanding of the ways in which radiation and chemicals cause biological damage.

  16. Biomedical Materials

    Institute of Scientific and Technical Information of China (English)

    CHANG Jiang; ZHOU Yanling

    2011-01-01

    @@ Biomedical materials, biomaterials for short, is regarded as "any substance or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as part of a system which treats, augments, or replaces any tissue, organ or function of the body" (Vonrecum & Laberge, 1995).Biomaterials can save lives, relieve suffering and enhance the quality of life for human being.

  17. Instructional leadership in elementary science: How are school leaders positioned to lead in a next generation science standards era?

    Science.gov (United States)

    Winn, Kathleen Mary

    The Next Generation Science Standards (NGSS) are the newest K-12 science content standards created by a coalition of educators, scientists, and researchers available for adoption by states and schools. Principals are important actors during policy implementation especially since principals are charged with assuming the role of an instructional leader for their teachers in all subject areas. Science poses a unique challenge to the elementary curricular landscape because traditionally, elementary teachers report low levels of self-efficacy in the subject. Support in this area therefore becomes important for a successful integration of a new science education agenda. This study analyzed self-reported survey data from public elementary principals (N=667) to address the following three research questions: (1) What type of science backgrounds do elementary principals have? (2) What indicators predict if elementary principals will engage in instructional leadership behaviors in science? (3) Does self-efficacy mediate the relationship between science background and a capacity for instructional leadership in science? The survey data were analyzed quantitatively. Descriptive statistics address the first research question and inferential statistics (hierarchal regression analysis and a mediation analysis) answer the second and third research questions.The sample data show that about 21% of elementary principals have a formal science degree and 26% have a degree in a STEM field. Most principals have not had recent experience teaching science, nor were they every exclusively a science teacher. The analyses suggests that demographic, experiential, and self-efficacy variables predict instructional leadership practices in science.

  18. A Review of Biomedical Composite Materials

    Institute of Scientific and Technical Information of China (English)

    吴珊珊

    2013-01-01

    This article addresses the review of the biomedical composite materials.It introduces the operational definition,the classification of biomedical composite materials,and its constituents within itself.In this thesis,the last part presents the application of this kind of material.By writing this paper,I hope that people will get a comprehensive knowledge of the biomedical composite material and make further and deeper research in this material by which way to animate the material science industry.

  19. Pacific Northwest Laboratory annual report for 1989 to the DOE Office of Energy Research - Part 1: Biomedical Sciences

    Energy Technology Data Exchange (ETDEWEB)

    Park, J.F.

    1990-05-01

    This report summarizes progress on OHER human health, biological, general life sciences, and medical applications research programs conducted at PNL in FY 1989. The research develops the knowledge and scientific principles necessary to identify, understand, and anticipate the long-term health consequences of energy-related radiation and chemicals. Our continuing emphasis is to decrease the uncertainty of health risk estimates from existing and developing energy-related technologies through an increased understanding of how radiation and chemicals cause biological damage. The sequence of this report of PNL research reflects the OHER programmatic structure. The first section, on human health research, concerns statistical and epidemiological studies for assessing health risks. The next section contains reports of biological research in laboratory animals and in vitro cell systems, including research with radionuclides and chemicals. The general life sciences research section reports research conducted for the OHER human genome research program, and the medical applications section summarizes commercial radioisotope production and distribution activities at DOE facilities. 6 refs., 50 figs., 35 tabs.

  20. International Co-authorship Relations in the Social Science Citation Index: Is Internationalization Leading the Network?

    CERN Document Server

    Leydesdorff, Loet; Wagner, Caroline

    2013-01-01

    We analyze international co-authorship relations in the Social Science Citation Index 2011 using all citable items in the DVD-version of this index. Network statistics indicate four groups of nations: (i) an Asian-Pacific one to which all Anglo-Saxon nations (including the UK and Ireland) are attributed; (ii) a continental European one including also the Latin-American countries; (iii) the Scandinavian nations; and (iv) a community of African nations. Within the EU-28 (including Croatia), eleven of the EU-15 states have dominant positions. Collapsing the EU-28 into a single node leads to a bi-polar structure between the US and EU-28; China is part of the US-pole. We develop an information-theoretical test to distinguish whether international collaborations or domestic collaborations prevail; the results are mixed, but the international dimension is more important than the national one in the aggregated sets (this was found in both SSCI and SCI). In France, however, the national distribution is more important ...

  1. [Projects to accelerate the practical use of innovative medical devices to collaborate with TWIns, Center for Advanced Biomedical Sciences, Waseda University and School of Engineering, The University of Tokyo].

    Science.gov (United States)

    Niimi, Shingo; Umezu, Mitsuo; Iseki, Hiroshi; Harada, Hiroshi Kasanuki Noboru; Mitsuishi, Mamoru; Kitamori, Takehiko; Tei, Yuichi; Nakaoka, Ryusuke; Haishima, Yuji

    2014-01-01

    Division of Medical Devices has been conducting the projects to accelerate the practical use of innovative medical devices to collaborate with TWIns, Center for Advanced Biomedical Sciences, Waseda University and School of Engineering, The University of Tokyo. The TWIns has been studying to aim at establishment of preclinical evaluation methods by "Engineering Based Medicine", and established Regulatory Science Institute for Medical Devices. School of Engineering, The University of Tokyo has been studying to aim at establishment of assessment methodology for innovative minimally invasive therapeutic devices, materials, and nanobio diagnostic devices. This report reviews the exchanges of personnel, the implement systems and the research progress of these projects.

  2. Integrated Biomaterials for Biomedical Technology

    CERN Document Server

    Ramalingam, Murugan; Ramakrishna, Seeram; Kobayashi, Hisatoshi

    2012-01-01

    This cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications. The volume consists of 12 chapters written by acknowledged experts of the biomaterials field and covers a wide range of topics and applications.

  3. Biomedical Engineering Education in Perspective

    Science.gov (United States)

    Gowen, Richard J.

    1973-01-01

    Discusses recent developments in the health care industry and their impact on the future of biomedical engineering education. Indicates that a more thorough understanding of the complex functions of the living organism can be acquired through the application of engineering techniques to problems of life sciences. (CC)

  4. Biomedical informatics: changing what physicians need to know and how they learn.

    Science.gov (United States)

    Stead, William W; Searle, John R; Fessler, Henry E; Smith, Jack W; Shortliffe, Edward H

    2011-04-01

    The explosive growth of biomedical complexity calls for a shift in the paradigm of medical decision making-from a focus on the power of an individual brain to the collective power of systems of brains. This shift alters professional roles and requires biomedical informatics and information technology (IT) infrastructure. The authors illustrate this future role of medical informatics with a vignette and summarize the evolving understanding of both beneficial and deleterious effects of informatics-rich environments on learning, clinical care, and research. The authors also provide a framework of core informatics competencies for health professionals of the future and conclude with broad steps for faculty development. They recommend that medical schools advance on four fronts to prepare their faculty to teach in a biomedical informatics-rich world: (1) create academic units in biomedical informatics; (2) adapt the IT infrastructure of academic health centers (AHCs) into testing laboratories; (3) introduce medical educators to biomedical informatics sufficiently for them to model its use; and (4) retrain AHC faculty to lead the transformation to health care based on a new systems approach enabled by biomedical informatics. The authors propose that embracing this collective and informatics-enhanced future of medicine will provide opportunities to advance education, patient care, and biomedical science.

  5. NIH/NSF accelerate biomedical research innovations

    Science.gov (United States)

    A collaboration between the National Science Foundation and the National Institutes of Health will give NIH-funded researchers training to help them evaluate their scientific discoveries for commercial potential, with the aim of accelerating biomedical in

  6. Organic Bioelectronic Tools for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Susanne Löffler

    2015-11-01

    Full Text Available Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients.

  7. Fraud and deceit in biomedical research

    Directory of Open Access Journals (Sweden)

    Buitrago Juliana

    2004-05-01

    Full Text Available History: Scientists are supposed to be moved by lofty ideals and be taught to work restlessly in pursue of the truth, but sadly fraud in biomedical research can be traced through the entire history of science. Definition: Nowadays, typology of fraud is clearly defined. Principal types of misconduct are reviewed. Consequences: It is impossible to know to what extent the damage will remain. Fraud threats public confidence in the integrity of science and may change professional attitudes and health public policies leading to serious social consequences. Evaluation of the problem: Prevalence of research fraud is unknown but in almost every country where investigation has been largely developed, at least a corroborated case of mis-conduct has been known. Policies on the scientific process may eventually contribute to fraudulent behaviour. Situation in Colombia: Colombia lacks of comprehensive policies to deal with fraud in research. How to tackle this problem: Finally, some recommendations are given to prevent, detect and deal with fraud in biomedical research.

  8. Writing intelligible English prose for biomedical journals.

    Science.gov (United States)

    Ludbrook, John

    2007-01-01

    1. I present a combination of semi-objective and subjective evidence that the quality of English prose in biomedical scientific writing is deteriorating. 2. I consider seven possible strategies for reversing this apparent trend. These refer to a greater emphasis on good writing by students in schools and by university students, consulting books on science writing, one-on-one mentoring, using 'scientific' measures to reveal lexical poverty, making use of freelance science editors and encouraging the editors of biomedical journals to pay more attention to the problem. 3. I conclude that a fruitful, long-term, strategy would be to encourage more biomedical scientists to embark on a career in science editing. This strategy requires a complementary initiative on the part of biomedical research institutions and universities to employ qualified science editors. 4. An immediately realisable strategy is to encourage postgraduate students in the biomedical sciences to undertake the service courses provided by many universities on writing English prose in general and scientific prose in particular. This strategy would require that heads of departments and supervisors urge their postgraduate students to attend such courses. 5. Two major publishers of biomedical journals, Blackwell Publications and Elsevier Science, now provide lists of commercial editing services on their web sites. I strongly recommend that authors intending to submit manuscripts to their journals (including Blackwell's Clinical and Experimental Pharmacology and Physiology) make use of these services. This recommendation applies especially to those for whom English is a second language.

  9. Environmental/Biomedical Terminology Index

    Energy Technology Data Exchange (ETDEWEB)

    Huffstetler, J.K.; Dailey, N.S.; Rickert, L.W.; Chilton, B.D.

    1976-12-01

    The Information Center Complex (ICC), a centrally administered group of information centers, provides information support to environmental and biomedical research groups and others within and outside Oak Ridge National Laboratory. In-house data base building and development of specialized document collections are important elements of the ongoing activities of these centers. ICC groups must be concerned with language which will adequately classify and insure retrievability of document records. Language control problems are compounded when the complexity of modern scientific problem solving demands an interdisciplinary approach. Although there are several word lists, indexes, and thesauri specific to various scientific disciplines usually grouped as Environmental Sciences, no single generally recognized authority can be used as a guide to the terminology of all environmental science. If biomedical terminology for the description of research on environmental effects is also needed, the problem becomes even more complex. The building of a word list which can be used as a general guide to the environmental/biomedical sciences has been a continuing activity of the Information Center Complex. This activity resulted in the publication of the Environmental Biomedical Terminology Index (EBTI).

  10. Environmental Sciences Division annual progress report for period ending September 30, 1982. Environmental Sciences Division Publication No. 2090. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    1983-04-01

    Separate abstracts were prepared for 12 of the 14 sections of the Environmental Sciences Division annual progress report. The other 2 sections deal with educational activities. The programs discussed deal with advanced fuel energy, toxic substances, environmental impacts of various energy technologies, biomass, low-level radioactive waste management, the global carbon cycle, and aquatic and terrestrial ecology. (KRM)

  11. The Accreditation Process for Science: The Path Leads to Unintended (Positive) Consequences

    Science.gov (United States)

    Kubitskey, Beth; Rutherford, Sandra; Wylo, Bonnie; Liggit, Peggy

    2011-01-01

    In this paper, we discuss how a community of scholars came together to create assessments across science departments for the initial teacher preparation program in secondary science teaching. The steps of the process taken to meet accreditation standards are described, as well as some surprising findings from our road trip down the path of…

  12. Renewed Attention to Social Sciences in China Leads to New Partnerships with American Universities

    Science.gov (United States)

    Hvistendahl, Mara

    2009-01-01

    Politics and a lack of money resulted in decades of neglect for the social sciences in China, by foreign and domestic institutions alike. American universities looking to establish partnerships here have focused instead on high-demand fields like finance and the hard sciences. But societal change, along with a government push to develop more…

  13. Rewiring the Corporate Brain: Using the New Science To Rethink How We Structure and Lead Organizations.

    Science.gov (United States)

    Zohar, Danah

    This book relates the radically new sciences of the 20th century--quantum mechanics, chaos theory, and complexity theory--to organizational problems and challenges facing corporate leaders. The book draws on the science of the human brain, with its three different kinds of neural structures--mental, emotional, and spiritual--to illustrate how to…

  14. International coauthorship relations in the Social Sciences Citation Index: is internationalization leading the network?

    NARCIS (Netherlands)

    Leydesdorff, L.; Park, H.W.; Wagner, C.

    2014-01-01

    International coauthorship relations have increasingly shaped another dynamic in the natural and life sciences during recent decades. However, much less is known about such internationalization in the social sciences. In this study, we analyze international and domestic coauthorship relations of all

  15. Basics of biomedical ultrasound for engineers

    CERN Document Server

    Azhari, Haim

    2010-01-01

    "Basics of Biomedical Ultrasound for Engineers is a structured textbook for university engineering courses in biomedical ultrasound and for researchers in the field. This book offers a tool for building a solid understanding of biomedical ultrasound, and leads the novice through the field in a step-by-step manner. The book begins with the most basic definitions of waves, proceeds to ultrasounds in fluids, and then delves into solid ultrasounds, the most complicated kind of ultrasound. It encompasses a wide range of topics within biomedical ultrasound, from conceptual definitions of waves to the intricacies of focusing devices, transducers, and acoustic fields"--Provided by publisher.

  16. Innovations in Biomedical Engineering 2016

    CERN Document Server

    Tkacz, Ewaryst; Paszenda, Zbigniew; Piętka, Ewa

    2017-01-01

    This book presents the proceedings of the “Innovations in Biomedical Engineering IBE’2016” Conference held on October 16–18, 2016 in Poland, discussing recent research on innovations in biomedical engineering. The past decade has seen the dynamic development of more and more sophisticated technologies, including biotechnologies, and more general technologies applied in the area of life sciences. As such the book covers the broadest possible spectrum of subjects related to biomedical engineering innovations. Divided into four parts, it presents state-of-the-art achievements in: • engineering of biomaterials, • modelling and simulations in biomechanics, • informatics in medicine • signal analysis The book helps bridge the gap between technological and methodological engineering achievements on the one hand and clinical requirements in the three major areas diagnosis, therapy and rehabilitation on the other.

  17. On the Crisis in Biomedical Education: Is There an Overproduction of Biomedical PhDs?

    Science.gov (United States)

    Domer, Judith E.; And Others

    1996-01-01

    The debate over whether there is an oversupply of doctorates in the biomedical sciences is examined, and a case study of doctoral graduates and postdoctoral fellows at the Tulane University (Louisiana) Medical Center is reported. It is concluded that there is no biomedical doctoral glut and that doctoral program downsizing would have serious…

  18. The ethics of biomedical big data

    CERN Document Server

    Mittelstadt, Brent Daniel

    2016-01-01

    This book presents cutting edge research on the new ethical challenges posed by biomedical Big Data technologies and practices. ‘Biomedical Big Data’ refers to the analysis of aggregated, very large datasets to improve medical knowledge and clinical care. The book describes the ethical problems posed by aggregation of biomedical datasets and re-use/re-purposing of data, in areas such as privacy, consent, professionalism, power relationships, and ethical governance of Big Data platforms. Approaches and methods are discussed that can be used to address these problems to achieve the appropriate balance between the social goods of biomedical Big Data research and the safety and privacy of individuals. Seventeen original contributions analyse the ethical, social and related policy implications of the analysis and curation of biomedical Big Data, written by leading experts in the areas of biomedical research, medical and technology ethics, privacy, governance and data protection. The book advances our understan...

  19. Securing a biomedical communications future: thinking strategically.

    Science.gov (United States)

    Stein, D

    1985-11-01

    Ensuring continued growth and viability of the biomedical communication function has become a critical task of the biomedical communications director. Thinking strategically is a cognitive process which assists a director in visualizing programs and tactics which meet clients needs, creates competitive advantages for the biomedical communications unit and builds on existing unit strengths. Thinking strategically can be divided into five phases: strategic vision, strategy development, strategic plan implementation, strategic plan dissemination, and strategic plan evaluation. Each sequence leads the biomedical communications director through a process designed to increase the effectiveness of the biomedical unit and to meet the challenges posed by an environment characterized by diminished financial, material, and human resources as well as respond to threats and opportunities posed by increased competition in the biomedical communications product and marketplace.

  20. Functionalized carbon nanotubes: biomedical applications

    Directory of Open Access Journals (Sweden)

    Vardharajula S

    2012-10-01

    Full Text Available Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh11Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, IndiaAbstract: Carbon nanotubes (CNTs are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applications

  1. Smoking Prevalence Among Mugla School of Health Sciences Students and Causes of Leading Increase in Smoking

    Directory of Open Access Journals (Sweden)

    Metin Picakciefe

    2007-08-01

    Full Text Available The purpose of this study was to determine the smoking prevalence among Mugla School of Health Sciences students, to determine the effects the increasing causes of smoking and their education about adverse health outcome of smoking. A cross-sectional study was performed among Mugla School of Health Sciences students in Mugla University. All students (417 in Mugla School of Health Sciences included in the study. The participation rates was 85.1%. Data were obtained by the self-administered questionnaire without teachers in classes. SPSS 11.0 was used for data analysis, and the differentiation was assessed by Chi-square analysis. P < 0.05 was accepted statistically significant. The prevalence of current smokers was 25.3% among students in Mugla School of Health Sciences. The students stated that the most important factor of smoking initiation was stress (59.2%. The univariable analysis showed that the friends’ smoking (p: 0.000 , having knowledge about smoking habits of teachers (p: 0.020 , alcohol consumption (p: 0.000, and other smokers out of parent in the home (p: 0.000 was significantly associated with increasing rate of smoking prevalence. The smoking prevalence was quite high (25.3% among Mugla School of Health Sciences students in Mugla University. It is needed to decreasing smoking prevalence among students that antismoking education should be reevaluated, that antismoking campaign should be administered in schools. [TAF Prev Med Bull. 2007; 6(4: 267-272

  2. Smoking Prevalence Among Mugla School of Health Sciences Students and Causes of Leading Increase in Smoking

    Directory of Open Access Journals (Sweden)

    Metin Picakciefe

    2007-08-01

    Full Text Available The purpose of this study was to determine the smoking prevalence among Mugla School of Health Sciences students, to determine the effects the increasing causes of smoking and their education about adverse health outcome of smoking. A cross-sectional study was performed among Mugla School of Health Sciences students in Mugla University. All students (417 in Mugla School of Health Sciences included in the study. The participation rates was 85.1%. Data were obtained by the self-administered questionnaire without teachers in classes. SPSS 11.0 was used for data analysis, and the differentiation was assessed by Chi-square analysis. P < 0.05 was accepted statistically significant. The prevalence of current smokers was 25.3% among students in Mugla School of Health Sciences. The students stated that the most important factor of smoking initiation was stress (59.2%. The univariable analysis showed that the friends’ smoking (p: 0.000 , having knowledge about smoking habits of teachers (p: 0.020 , alcohol consumption (p: 0.000, and other smokers out of parent in the home (p: 0.000 was significantly associated with increasing rate of smoking prevalence. The smoking prevalence was quite high (25.3% among Mugla School of Health Sciences students in Mugla University. It is needed to decreasing smoking prevalence among students that antismoking education should be reevaluated, that antismoking campaign should be administered in schools. [TAF Prev Med Bull 2007; 6(4.000: 267-272

  3. Japanese representation in leading general medicine and basic science journals: a comparison of two decades.

    Science.gov (United States)

    Fukui, Tsuguya; Takahashi, Osamu; Rahman, Mahbubur

    2013-01-01

    During 1991-2000, Japan contribution to the top general medicine journals was very small although the contribution to the top basic science journals was sizeable. However, it has not been examined whether the contribution to the top general medicine and basic science journals has changed during the last decade (2001-2010). The objective of this study was to compare Japan representation in high-impact general medicine and basic science journals between the years 1991-2000 and 2001-2010. We used PubMed database to examine the frequency of articles originated from Japan and published in 7 high-impact general medicine and 6 high-impact basic science journals. Several Boolean operators were used to connect name of the journal, year of publication and corresponding authors' affiliation in Japan. Compared to the 1991-2000 decade, Japan contribution to the top general medicine journals did not increase over the 2001-2010 period (0.66% vs. 0.74%, P = 0.255). However, compared to the same period, its contribution to the top basic science journals increased during 2001-2010 (2.51% vs. 3.60%, P journals showed an upward trend over the 1991-2000 period (P journals remained flat both during 1991-2000 (P = 0.273) and 2001-2010 (P = 0.073). Overall, Japan contribution to the top general medicine journals has remained small and unchanged over the last two decades. However, top basic science journals had higher Japan representation during 2001-2010 compared to 1991-2000.

  4. [Biomedical research in Revista de Biologia Tropical].

    Science.gov (United States)

    Gutiérrez, José María

    2002-01-01

    The contributions published in Revista de Biología Tropical in the area of Biomedical Sciences are reviewed in terms of number of contributions and scope of research subjects. Biomedical Sciences, particularly Parasitology and Microbiology, constituted the predominant subject in the Revista during the first decade, reflecting the intense research environment at the School of Microbiology of the University of Costa Rica and at Hospital San Juan de Dios. The relative weight of Biomedicine in the following decades diminished, due to the outstanding increment in publications in Biological Sciences; however, the absolute number of contributions in Biomedical Sciences remained constant throughout the last decades, with around 80 contributions per decade. In spite of the predominance of Parasitology as the main biomedical subject, the last decades have witnessed the emergence of new areas of interest in the Revista, such as Pharmacology of natural products, Toxinology, especially related to snake venoms, and Human Genetics. This retrospective analysis evidences that Biomedical Sciences, particularly those related to Tropical Medicine, were a fundamental component during the first years of Revista de Biología Tropical, and have maintained a significant presence in the scientific output of this journal, the most relevant scientific publication in biological sciences in Central America.

  5. Environmental Sciences Division. Annual progress report for period ending September 30, 1980. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Auerbach, S.I.; Reichle, D.E.

    1981-03-01

    Research conducted in the Environmental Sciences Division for the Fiscal Year 1980 included studies carried out in the following Division programs and sections: (1) Advanced Fossil Energy Program, (2) Nuclear Program, (3) Environmental Impact Program, (4) Ecosystem Studies Program, (5) Low-Level Waste Research and Development Program, (6) National Low-Level Waste Program, (7) Aquatic Ecology Section, (8) Environmental Resources Section, (9) Earth Sciences Section, and (10) Terrestrial Ecology Section. In addition, Educational Activities and the dedication of the Oak Ridge National Environmental Research Park are reported. Separate abstracts were prepared for the 10 sections of this report.

  6. Refutations in science texts lead to hypercorrection of misconceptions held with high confidence

    NARCIS (Netherlands)

    Van Loon, Mariëtte H.; Dunlosky, John; Van Gog, Tamara; Van Merriënboer, Jeroen J.g.; De Bruin, Anique B.h.

    2015-01-01

    Misconceptions about science are often not corrected during study when they are held with high confidence. However, when corrective feedback co-activates a misconception together with the correct conception, this feedback may surprise the learner and draw attention, especially when the misconception

  7. Biomedical technology

    CERN Document Server

    Wriggers, Peter

    2015-01-01

    During the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types o...

  8. Handbook of photonics for biomedical engineering

    CERN Document Server

    Kim, Donghyun; Somekh, Michael

    2017-01-01

    Nanophotonics has emerged rapidly into technological mainstream with the advent and maturity of nanotechnology available in photonics and enabled many new exciting applications in the area of biomedical science and engineering that were unimagined even a few years ago with conventional photonic engineering techniques. Handbook of Nanophotonics in Biomedical Engineering is intended to be a reliable resource to a wealth of information on nanophotonics that can inspire readers by detailing emerging and established possibilities of nanophotonics in biomedical science and engineering applications. This comprehensive reference presents not only the basics of nanophotonics but also explores recent experimental and clinical methods used in biomedical and bioengineering research. Each peer-reviewed chapter of this book discusses fundamental aspects and materials/fabrication issues of nanophotonics, as well as applications in interfaces, cell, tissue, animal studies, and clinical engineering. The organization provides ...

  9. Biomedical wellness challenges and opportunities

    Science.gov (United States)

    Tangney, John F.

    2012-06-01

    The mission of ONR's Human and Bioengineered Systems Division is to direct, plan, foster, and encourage Science and Technology in cognitive science, computational neuroscience, bioscience and bio-mimetic technology, social/organizational science, training, human factors, and decision making as related to future Naval needs. This paper highlights current programs that contribute to future biomedical wellness needs in context of humanitarian assistance and disaster relief. ONR supports fundamental research and related technology demonstrations in several related areas, including biometrics and human activity recognition; cognitive sciences; computational neurosciences and bio-robotics; human factors, organizational design and decision research; social, cultural and behavioral modeling; and training, education and human performance. In context of a possible future with automated casualty evacuation, elements of current science and technology programs are illustrated.

  10. Advanced computational approaches to biomedical engineering

    CERN Document Server

    Saha, Punam K; Basu, Subhadip

    2014-01-01

    There has been rapid growth in biomedical engineering in recent decades, given advancements in medical imaging and physiological modelling and sensing systems, coupled with immense growth in computational and network technology, analytic approaches, visualization and virtual-reality, man-machine interaction and automation. Biomedical engineering involves applying engineering principles to the medical and biological sciences and it comprises several topics including biomedicine, medical imaging, physiological modelling and sensing, instrumentation, real-time systems, automation and control, sig

  11. Identifying the Factors Leading to Success: How an Innovative Science Curriculum Cultivates Student Motivation

    Science.gov (United States)

    Scogin, Stephen C.

    2016-06-01

    PlantingScience is an award-winning program recognized for its innovation and use of computer-supported scientist mentoring. Science learners work on inquiry-based experiments in their classrooms and communicate asynchronously with practicing plant scientist-mentors about the projects. The purpose of this study was to identify specific factors contributing to the program's effectiveness in engaging students. Using multiple data sources, grounded theory (Strauss and Corbin in Basics of qualitative research. Sage, Newbury Park, 1990) was used to develop a conceptual model identifying the central phenomenon, causal conditions, intervening conditions, strategies, contexts, and student outcomes of the project. Student motivation was determined to be the central phenomenon explaining the success of the program, with student empowerment, online mentor interaction, and authenticity of the scientific experiences serving as causal conditions. Teachers contributed to student motivation by giving students more freedom, challenging students to take projects deeper, encouraging, and scaffolding. Scientists contributed to student motivation by providing explanations, asking questions, encouraging, and offering themselves as partners in the inquiry process. Several positive student outcomes of the program were uncovered and included increased positivity, greater willingness to take projects deeper, better understanding of scientific concepts, and greater commitments to collaboration. The findings of this study provide relevant information on how to develop curriculum, use technology, and train practitioners and mentors to utilize strategies and actions that improve learners' motivation to engage in authentic science in the classroom.

  12. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardia

  13. The National Center for Biomedical Ontology: Advancing Biomedicinethrough Structured Organization of Scientific Knowledge

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, Daniel L.; Lewis, Suzanna E.; Mungall, Chris J.; Misra,Sima; Westerfield, Monte; Ashburner, Michael; Sim, Ida; Chute,Christopher G.; Solbrig, Harold; Storey, Margaret-Anne; Smith, Barry; Day-Richter, John; Noy, Natalya F.; Musen, Mark A.

    2006-01-23

    The National Center for Biomedical Ontology (http://bioontology.org) is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists funded by the NIH Roadmap to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are: (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. The Center is working toward these objectives by providing tools to develop ontologies and to annotate experimental data, and by developing resources to integrate and relate existing ontologies as well as by creating repositories of biomedical data that are annotated using those ontologies. The Center is providing training workshops in ontology design, development, and usage, and is also pursuing research in ontology evaluation, quality, and use of ontologies to promote scientific discovery. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease.

  14. [From human genome to man-made life: J. Craig Venter leads the life sciences].

    Science.gov (United States)

    Sun, Mingwei; Li, Yin; Gao, George F

    2010-06-01

    For the first time ever, the scientists of J. Craig Venter team have created actual self-replicating synthetic life. The research was just published in the Journal of Science on May 20, 2010. Although this news immediately brings the worry about the possible potential threat to biosecurity and biosafety as well as the ethical disputes, it yet indicates that mankind have made a new step forward in synthetic biology. In the time of post-genome era, we believe the advancement of synthetic biology that might affect or change the future life of human being will be widely used in energy, environment, materials, medication and many other fields.

  15. Education and research in biomedical engineering of the Budapest University of Technology and Economics.

    Science.gov (United States)

    Benyó, Z

    2006-03-01

    Biomedical Engineering is a relatively new interdisciplinary science. This review paper presents the biomedical engineering activity, which is carried out at the Budapest University of Technology and Economics (BUTE) and its partner institutions. In the first parts the main goals and the curriculum of the Biomedical Engineering Education Program is presented. The second part of the paper summarizes the most important biomedical engineering researches most of them carried out in the Biomedical Engineering Laboratory of BUTE.

  16. The Science of Change: The Importance of Methodology in Leading Change in the Army

    Science.gov (United States)

    2007-05-24

    the institution. The scope of these changes is unprecedented and the potential for “organizational whiplash ” is extremely high. Therefore, the...here that CM is the highest order and that all other models, to include tools such as LSS, should be selected and applied as appropriate only after ...potential obstacles in their efforts to lead change in the Army, even after only a cursory review of the model. So, while the table conveniently

  17. 15th International Conference on Biomedical Engineering

    CERN Document Server

    2014-01-01

    This volume presents the proceedings of the 15th ICMBE held from 4th to 7th December 2013, Singapore. Biomedical engineering is applied in most aspects of our healthcare ecosystem. From electronic health records to diagnostic tools to therapeutic, rehabilitative and regenerative treatments, the work of biomedical engineers is evident. Biomedical engineers work at the intersection of engineering, life sciences and healthcare. The engineers would use principles from applied science including mechanical, electrical, chemical and computer engineering together with physical sciences including physics, chemistry and mathematics to apply them to biology and medicine. Applying such concepts to the human body is very much the same concepts that go into building and programming a machine. The goal is to better understand, replace or fix a target system to ultimately improve the quality of healthcare. With this understanding, the conference proceedings offer a single platform for individuals and organisations working i...

  18. Biomedical engineering and society: policy and ethics.

    Science.gov (United States)

    Flexman, J A; Lazareck, L

    2007-01-01

    Biomedical engineering impacts health care and contributes to fundamental knowledge in medicine and biology. Policy, such as through regulation and research funding, has the potential to dramatically affect biomedical engineering research and commercialization. New developments, in turn, may affect society in new ways. The intersection of biomedical engineering and society and related policy issues must be discussed between scientists and engineers, policy-makers and the public. As a student, there are many ways to become engaged in the issues surrounding science and technology policy. At the University of Washington in Seattle, the Forum on Science Ethics and Policy (FOSEP, www.fosep.org) was started by graduate students and post-doctoral fellows interested in improving the dialogue between scientists, policymakers and the public and has received support from upper-level administration. This is just one example of how students can start thinking about science policy and ethics early in their careers.

  19. The Potential Improvement of Team-Working Skills in Biomedical and Natural Science Students Using a Problem-Based Learning Approach

    Science.gov (United States)

    Nowrouzian, Forough L.; Farewell, Anne

    2013-01-01

    Teamwork has become an integral part of most organisations today, and it is clearly important in Science and other disciplines. In Science, research teams increase in size while the number of single-authored papers and patents decline. Team-work in laboratory sciences permits projects that are too big or complex for one individual to be tackled.…

  20. Evaluation of research in biomedical ontologies.

    Science.gov (United States)

    Hoehndorf, Robert; Dumontier, Michel; Gkoutos, Georgios V

    2013-11-01

    Ontologies are now pervasive in biomedicine, where they serve as a means to standardize terminology, to enable access to domain knowledge, to verify data consistency and to facilitate integrative analyses over heterogeneous biomedical data. For this purpose, research on biomedical ontologies applies theories and methods from diverse disciplines such as information management, knowledge representation, cognitive science, linguistics and philosophy. Depending on the desired applications in which ontologies are being applied, the evaluation of research in biomedical ontologies must follow different strategies. Here, we provide a classification of research problems in which ontologies are being applied, focusing on the use of ontologies in basic and translational research, and we demonstrate how research results in biomedical ontologies can be evaluated. The evaluation strategies depend on the desired application and measure the success of using an ontology for a particular biomedical problem. For many applications, the success can be quantified, thereby facilitating the objective evaluation and comparison of research in biomedical ontology. The objective, quantifiable comparison of research results based on scientific applications opens up the possibility for systematically improving the utility of ontologies in biomedical research.

  1. 面向生物医学影像e-Science平台的审计监控系统%An Auditing and Monitoring System for Biomedical Image E-Science Platform

    Institute of Scientific and Technical Information of China (English)

    王土生; 杨媛媛; 张建国

    2013-01-01

    During Research in biomedical imaging and clinical applications for major diseases, it is often necessary to involve scientist of basic medicine, clinical medicine, physics and biomedical engineering for collaborative research. To do this, we built a grid-based biomedical image e-Science platform, providing data sharing and exchange between the different institutions. Due to the distribution of system and node heterogeneity, it is difficult to avoid the system hardware and software failures. Therefore, this paper designed an XMPP-based audit and monitoring system, which supports both real-time monitoring of each host, and auditing of the data business happening in e-Science. The system is running with e-Science platform, showing good convenient and soundness.%在面向重大疾病的生物医学成像与临床应用等研究中,常常需要包括基础医学、临床医学、物理学和生物医学工程多学科的科研工作者进行协同交互。为此采用网格技术构建了生物医学影像e-Science平台,实现了跨机构之间大数据的快速共享与交换。由于系统的分布性和节点的异构性,难以避免会碰到系统的软硬件故障。因此,设计了一种基于XMPP协议的审计监控系统,既对e-Science的各个主机系统资源进行实时监测,又对平台中数据业务进行审计跟踪。系统最终被部署应用在e-Science平台,具有良好的便捷性和稳健性。

  2. VI Latin American Congress on Biomedical Engineering

    CERN Document Server

    Hadad, Alejandro

    2015-01-01

    This volume presents the proceedings of the CLAIB 2014, held in Paraná, Entre Ríos, Argentina 29, 30 & 31 October 2014. The proceedings, presented by the Regional Council of Biomedical Engineering for Latin America (CORAL) offer research findings, experiences and activities between institutions and universities to develop Bioengineering, Biomedical Engineering and related sciences. The conferences of the American Congress of Biomedical Engineering are sponsored by the International Federation for Medical and Biological Engineering (IFMBE), Society for Engineering in Biology and Medicine (EMBS) and the Pan American Health Organization (PAHO), among other organizations and international agencies and bringing together scientists, academics and biomedical engineers in Latin America and other continents in an environment conducive to exchange and professional growth. The Topics include: - Bioinformatics and Computational Biology - Bioinstrumentation; Sensors, Micro and Nano Technologies - Biomaterials, Tissu...

  3. UK Doubles Its "World-Leading" Research in Life Sciences and Medicine in Six Years: Testing the Claim?

    Directory of Open Access Journals (Sweden)

    Steven Wooding

    Full Text Available The UK, like some other countries, carries out a periodic review of research quality in universities and the most recent Research Excellence Framework (REF reported a doubling (103% increase in its "world leading" or so-called "4*" research outputs in the areas of life sciences and medicine between 2008 and 2014. This is a remarkable improvement in six years and if validated internationally could have profound implications for health sciences.We compared the reported changes in 4* quality to bibliometric measures of quality for the 56,639 articles submitted to the RAE 2008 and the 50,044 articles submitted to the REF 2014 to Panel A, which assesses the life sciences, including medicine.UK research submitted to the RAE and REF was of better quality than worldwide research on average. While we found evidence for some increase in the quality of top UK research articles, a 10-25% increase in the top 10%ile papers, depending upon the metrics used, we could not find evidence to support a 103% increase in quality. Instead we found that as compared to the RAE, the REF results implied a lower citation %ile threshold for declaring a 4*.There is a wide discrepancy between bibliometric indices and peer-review panel judgements between the RAE 2008 and REF 2014. It is possible that the changes in the funding regime between 2008 and 2014 that significantly increased the financial premium for 4* articles may have influenced research quality evaluation. For the advancement of science and health, evaluation of research quality requires consistency and validity - the discrepancy noted here calls for a closer examination of mass peer-review methods like the REF.

  4. "small problems, Big Trouble": An Art and Science Collaborative Exhibition Reflecting Seemingly small problems Leading to Big Threats

    Science.gov (United States)

    Waller, J. L.; Brey, J. A.

    2014-12-01

    "small problems, Big Trouble" (spBT) is an exhibition of artist Judith Waller's paintings accompanied by text panels written by Earth scientist Dr. James A. Brey and several science researchers and educators. The text panels' message is as much the focus of the show as the art--true interdisciplinarity! Waller and Brey's history of art and earth science collaborations include the successful exhibition "Layers: Places in Peril". New in spBT is extended collaboration with other scientists in order to create awareness of geoscience and other subjects (i.e. soil, parasites, dust, pollutants, invasive species, carbon, ground water contaminants, solar wind) small in scale which pose significant threats. The paintings are the size of a mirror, a symbol suggesting the problems depicted are those we increasingly need to face, noting our collective reflections of shared current and future reality. Naturalistic rendering and abstract form in the art helps reach a broad audience including those familiar with art and those familiar with science. The goal is that gallery visitors gain greater appreciation and understanding of both—and of the sober content of the show as a whole. "small problems, Big Trouble" premiers in Wisconsin April, 2015. As in previous collaborations, Waller and Brey actively utilize art and science (specifically geoscience) as an educational vehicle for active student learning. Planned are interdisciplinary university and area high school activities linked through spBT. The exhibition in a public gallery offers a means to enhance community awareness of and action on scientific issues through art's power to engage people on an emotional level. This AGU presentation includes a description of past Waller and Brey activities: incorporating art and earth science in lab and studio classrooms, producing gallery and museum exhibitions and delivering workshops and other presentations. They also describe how walking the paths of several past earth science

  5. Joseph F. Keithley Award For Advances in Measurement Science Lecture: Thermophotonic and Photoacoustic Radar Imaging Methods for Biomedical and Dental Imaging

    Science.gov (United States)

    Mandelis, Andreas

    2012-02-01

    In the first part of this presentation I will introduce thermophotonic radar imaging principles and techniques using chirped or binary-phase-coded modulation, methods which can break through the maximum detection depth/depth resolution limitations of conventional photothermal waves. Using matched-filter principles, a methodology enabling parabolic diffusion-wave energy fields to exhibit energy localization akin to propagating hyperbolic wave-fields has been developed. It allows for deconvolution of individual responses of superposed axially discrete sources, opening a new field: depth-resolved thermal coherence tomography. Several examples from dental enamel caries diagnostic imaging to metal subsurface defect thermographic imaging will be discussed. The second part will introduce the field of photoacoustic radar (or sonar) biomedical imaging. I will report the development of a novel biomedical imaging system that utilizes a continuous-wave laser source with a custom intensity modulation pattern, ultrasonic phased array for signal detection and processing coupled with a beamforming algorithm for reconstruction of photoacoustic correlation images. Utilization of specific chirped modulation waveforms (``waveform engineering'') achieves dramatic signal-to-noise-ratio increase and improved axial resolution over pulsed laser photoacoustics. The talk will conclude with aspects of instrumental sensitivity of the PA Radar to optical contrast using cancerous breast tissue-mimicking phantoms, super paramagnetic iron oxide nanoparticles as contrast enhancement agents and in-vivo tissue samples.

  6. Biomedical Engineering Laboratory

    Science.gov (United States)

    2007-11-02

    The Masters of Engineering program with concentration in Biomedical Engineering at Tennessee State University was established in fall 2000. Under... biomedical engineering . The lab is fully equipped with 10 Pentium5-based, 2 Pentium4-based laptops for mobile experiments at remote locations, 8 Biopac...students (prospective graduate students in biomedical engineering ) are regularly using this lab. This summer, 8 new prospective graduate students

  7. Manpower development for the biomedical industry space.

    Science.gov (United States)

    Goh, James C H

    2013-01-01

    The Biomedical Sciences (BMS) Cluster is one of four key pillars of the Singapore economy. The Singapore Government has injected research funding for basic and translational research to attract companies to carry out their commercial R&D activities. To further intensify the R&D efforts, the National Research Foundation (NRF) was set up to coordinate the research activities of different agencies within the larger national framework and to fund strategic R&D initiatives. In recent years, funding agencies began to focus on support of translational and clinical research, particularly those with potential for commercialization. Translational research is beginning to have traction, in particular research funding for the development of innovation medical devices. Therefore, the Biomedical Sciences sector is projected to grow which means that there is a need to invest in human capital development to achieve sustainable growth. In support of this, education and training programs to strengthen the manpower capabilities for the Biomedical Sciences industry have been developed. In recent years, undergraduate and graduate degree courses in biomedical engineering/bioengineering have been developing at a rapid rate. The goal is to train students with skills to understand complex issues of biomedicine and to develop and implement of advanced technological applications to these problems. There are a variety of career opportunities open to graduates in biomedical engineering, however regardless of the type of career choices, students must not only focus on achieving good grades. They have to develop their marketability to employers through internships, overseas exchange programs, and involvement in leadership-type activities. Furthermore, curriculum has to be developed with biomedical innovation in mind and ensure relevance to the industry. The objective of this paper is to present the NUS Bioengineering undergraduate program in relation to manpower development for the biomedical

  8. Biomedical and environmental applications of magnetic nanoparticles

    Science.gov (United States)

    Tran, Dai Lam; Le, Van Hong; Linh Pham, Hoai; Nhung Hoang, Thi My; Quy Nguyen, Thi; Luong, Thien Tai; Thu Ha, Phuong; Phuc Nguyen, Xuan

    2010-12-01

    This paper presents an overview of syntheses and applications of magnetic nanoparticles (MNPs) at the Institute of Materials Science, Vietnam Academy of Science and Technology. Three families of oxide MNPs, magnetite, manganite and spinel ferrite materials, were prepared in various ways: coprecipitation, sol-gel and high energy mechanical milling. Basic properties of MNPs were characterized by Vibrating Sample Magnetometer (VSM) and Physical Properties Measurement Systems (PPMS). As for biomedical application, the aim was to design a novel multifunctional, nanosized magnetofluorescent water-dispersible Fe3O4-curcumin conjugate, and its ability to label, target and treat tumor cells was described. The conjugate possesses a magnetic nano Fe3O4 core, chitosan (CS) or Oleic acid (OL) as an outer shell and entrapped curcumin (Cur), serving the dual function of naturally autofluorescent dye as well as antitumor model drug. Fe3O4-Cur conjugate exhibited a high loading cellular uptake with the help of a macrophage, which was clearly visualized dually by Fluorescence Microscope and Laser Scanning Confocal Microscope (LSCM), as well as by magnetization measurement (PPMS). A preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using the conjugate. As for the environmental aspect, the use of magnetite MNPs for the removal of heavy toxic metals, such as Arsenic (As) and Lead (Pb), from contaminated water was studied.

  9. Biomedical engineering principles

    CERN Document Server

    Ritter, Arthur B; Valdevit, Antonio; Ascione, Alfred N

    2011-01-01

    Introduction: Modeling of Physiological ProcessesCell Physiology and TransportPrinciples and Biomedical Applications of HemodynamicsA Systems Approach to PhysiologyThe Cardiovascular SystemBiomedical Signal ProcessingSignal Acquisition and ProcessingTechniques for Physiological Signal ProcessingExamples of Physiological Signal ProcessingPrinciples of BiomechanicsPractical Applications of BiomechanicsBiomaterialsPrinciples of Biomedical Capstone DesignUnmet Clinical NeedsEntrepreneurship: Reasons why Most Good Designs Never Get to MarketAn Engineering Solution in Search of a Biomedical Problem

  10. Fundamental of biomedical engineering

    CERN Document Server

    Sawhney, GS

    2007-01-01

    About the Book: A well set out textbook explains the fundamentals of biomedical engineering in the areas of biomechanics, biofluid flow, biomaterials, bioinstrumentation and use of computing in biomedical engineering. All these subjects form a basic part of an engineer''s education. The text is admirably suited to meet the needs of the students of mechanical engineering, opting for the elective of Biomedical Engineering. Coverage of bioinstrumentation, biomaterials and computing for biomedical engineers can meet the needs of the students of Electronic & Communication, Electronic & Instrumenta

  11. The 'Food Polymer Science' Approach to the Practice of Industrial R&D, Leading to Patent Estates Based on Fundamental Starch Science and Technology.

    Science.gov (United States)

    Slade, Louise; Levine, Harry

    2016-09-22

    This paper reviews the application of the 'Food Polymer Science' approach to the practice of industrial R&D, leading to patent estates based on fundamental starch science and technology . The areas of patents and patented technologies reviewed here include: a) soft-from-the-freezer ice creams and freezer-storage-stable frozen bread dough products, based on 'cryostabilization technology' of frozen foods, utilizing commercial starch hydrolysis products (SHPs); b) glassy-matrix encapsulation technology for flavors and other volatiles, based on structure-function relationships for commercial SHPs; c) production of stabilized whole-grain wheat flours for biscuit products, based on the application of 'solvent retention capacity' technology to develop flours with reduced damaged starch; d) production of improved-quality, low-moisture cookies and crackers, based on pentosanase enzyme technology; e) production of 'baked-not-fried', chip-like, starch-based snack products, based on the use of commercial modified-starch ingredients with selected functionality; f) accelerated staling of a starch-based food product from baked bread crumb, based on the kinetics of starch retrogradation, treated as a crystallization process for a partially crystalline glassy polymer system; g) a process for producing an enzyme-resistant starch, for use as a reduced-calorie flour replacer in a wide range of grain-based food products, including cookies, extruded expanded snacks, and breakfast cereals.

  12. A study on knowledge and practice regarding biomedical waste management among staff nurses and nursing students of Rajendra Institute of Medical Sciences, Ranchi

    Directory of Open Access Journals (Sweden)

    Shamim Haider

    2015-03-01

    Full Text Available Background: Hospitals are the centre of cure and also the important centres of infectious waste generation. Effective management of Biomedical Waste (BMW is not only a legal necessity but also a social responsibility. Aims and Objectives: To assess the knowledge and practice in managing the biomedical wastes among nursing staff and student nurses in RIMS, Ranchi. Materials and methods: The study was conducted at RIMS, Ranchi from Oct 2013 to March 2014 (6 months. It was a descriptive, hospital based, cross-sectional study. A total of 240 nurses participated in the present study, randomly chosen from various departments A pre-designed, pre-tested, structured proforma was used for data collection after getting their informed consent. Self-made scoring system was used to categorize the participants as having good, average and poor scores. Data was tabulated and analyzed using percentages and chi-square test. Results: The knowledge regarding general information about BMW management was assessed(with scores 0-8,it was found  that level of knowledge was better in student nurses than staff nurses as student nurses scored good(6-8correct answers in more than half of the questions (65%.Whereas staff nurses scored good in only 33.33% questions. When the practical information regarding the BMW management is assessed (with scores 0-8, it was found that staff nurses had relatively better practice regarding BMW management than students as they scored good(6-8correct answers in 40% and 30% respectively. Conclusion: Though overall knowledge of study participants was good but still they need good quality training to improve their current knowledge about BMW. 

  13. Capturing the Value of Biomedical Research.

    Science.gov (United States)

    Bertuzzi, Stefano; Jamaleddine, Zeina

    2016-03-24

    Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information system from scratch that has been afforded by the Sidra Medical and Research Center in Qatar. This experiment is part of the global conversation on maximizing returns on research investment.

  14. Lead Poisoning

    Science.gov (United States)

    ... Topics Environment & Health Healthy Living Pollution Reduce, Reuse, Recycle Science – How It Works The Natural World Games ... OTHERS: Lead has recently been found in some plastic mini-blinds and vertical blinds which were made ...

  15. Improving Graduate Education to Support a Branching Career Pipeline: Recommendations Based on a Survey of Doctoral Students in the Basic Biomedical Sciences

    Science.gov (United States)

    Fuhrmann, C. N.; Halme, D. G.; O'Sullivan, P. S.; Lindstaedt, B.

    2011-01-01

    Today's doctoral programs continue to prepare students for a traditional academic career path despite the inadequate supply of research-focused faculty positions. We advocate for a broader doctoral curriculum that prepares trainees for a wide range of science-related career paths. In support of this argument, we describe data from our survey of…

  16. Powering biomedical devices

    CERN Document Server

    Romero, Edwar

    2013-01-01

    From exoskeletons to neural implants, biomedical devices are no less than life-changing. Compact and constant power sources are necessary to keep these devices running efficiently. Edwar Romero's Powering Biomedical Devices reviews the background, current technologies, and possible future developments of these power sources, examining not only the types of biomedical power sources available (macro, mini, MEMS, and nano), but also what they power (such as prostheses, insulin pumps, and muscular and neural stimulators), and how they work (covering batteries, biofluids, kinetic and ther

  17. Biomedical applications of polymers

    CERN Document Server

    Gebelein, C G

    1991-01-01

    The biomedical applications of polymers span an extremely wide spectrum of uses, including artificial organs, skin and soft tissue replacements, orthopaedic applications, dental applications, and controlled release of medications. No single, short review can possibly cover all these items in detail, and dozens of books andhundreds of reviews exist on biomedical polymers. Only a few relatively recent examples will be cited here;additional reviews are listed under most of the major topics in this book. We will consider each of the majorclassifications of biomedical polymers to some extent, inclu

  18. Handbook of biomedical optics

    CERN Document Server

    Boas, David A

    2011-01-01

    Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.Organized into six sections, this handbook: Contains intr

  19. Sensors for biomedical applications

    NARCIS (Netherlands)

    Bergveld, Piet

    1986-01-01

    This paper considers the impact during the last decade of modern IC technology, microelectronics, thin- and thick-film technology, fibre optic technology, etc. on the development of sensors for biomedical applications.

  20. Statistics in biomedical research

    OpenAIRE

    González-Manteiga, Wenceslao; Cadarso-Suárez, Carmen

    2007-01-01

    The discipline of biostatistics is nowadays a fundamental scientific component of biomedical, public health and health services research. Traditional and emerging areas of application include clinical trials research, observational studies, physiology, imaging, and genomics. The present article reviews the current situation of biostatistics, considering the statistical methods traditionally used in biomedical research, as well as the ongoing development of new methods in response to the new p...

  1. Biomedical signal processing

    CERN Document Server

    Akay, Metin

    1994-01-01

    Sophisticated techniques for signal processing are now available to the biomedical specialist! Written in an easy-to-read, straightforward style, Biomedical Signal Processing presents techniques to eliminate background noise, enhance signal detection, and analyze computer data, making results easy to comprehend and apply. In addition to examining techniques for electrical signal analysis, filtering, and transforms, the author supplies an extensive appendix with several computer programs that demonstrate techniques presented in the text.

  2. Biomedical signal analysis

    CERN Document Server

    Rangayyan, Rangaraj M

    2015-01-01

    The book will help assist a reader in the development of techniques for analysis of biomedical signals and computer aided diagnoses with a pedagogical examination of basic and advanced topics accompanied by over 350 figures and illustrations. Wide range of filtering techniques presented to address various applications. 800 mathematical expressions and equations. Practical questions, problems and laboratory exercises. Includes fractals and chaos theory with biomedical applications.

  3. [Biomedical engineering today : An overview from the viewpoint of the German Biomedical Engineering Society].

    Science.gov (United States)

    Schlötelburg, C; Becks, T; Stieglitz, T

    2010-08-01

    Biomedical engineering is characterized by the interdisciplinary co-operation of technology, science, and ways of thinking, probably more than any other technological area. The close interaction of engineering and information sciences with medicine and biology results in innovative products and methods, but also requires high standards for the interdisciplinary transfer of ideas into products for patients' benefits. This article describes the situation of biomedical engineering in Germany. It displays characteristics of the medical device industry and ranks it with respect to the international market. The research landscape is described as well as up-to-date research topics and trends. The national funding situation of research in biomedical engineering is reviewed and existing innovation barriers are discussed.

  4. The 1991 Lead/Copper Drinking Water Rule and the 1995 Decision Not to Revise the Arsenic Drinking Water Rule: Two Case Studies in EPA's Use of Science

    OpenAIRE

    Powell, Mark

    1996-01-01

    This paper discusses EPA's acquisition and use of science in two decisions under the Safe Drinking Water Act: the 1991 revision of the lead drinking water regulations and the 1995 decision to pursue additional research instead of revising the arsenic in drinking water standard. In the first case, a committed band of policy entrepreneurs within EPA mobilized and supplemented scientific information which had accumulated in the agency's air program to force lead in drinking water up the agency's...

  5. [Reflections about the historical development of biomedical sciences in Chile and the role of Revista Médica de Chile: an homage on 130-years old].

    Science.gov (United States)

    Vargas Fernández, Luis

    2002-12-01

    When Revista Médica de Chile turns to be 130 years old, the author reflects about the difficulties that scientific and technological creativity faces in Chile, considering that there was a 70 years gap between its historical origin in Chile compared to developed countries. The scientific progress erases the boundaries between Biomedicine and science and technology. This progress has resulted in an improvement in the quality of scientific publications in Revista Medica de Chile. The editorial work has also contributed to this improvement. Revista Medica de Chile has obtained international recognition and stands in a good position as a medical journal in Latin America and Chile.

  6. Integrating behavioral and biomedical research in HIV interventions: challenges and opportunities.

    Science.gov (United States)

    Rausch, Dianne M; Grossman, Cynthia I; Erbelding, Emily J

    2013-06-01

    Recent clinical trials have demonstrated overwhelming success of biomedical tools to prevent the spread of HIV infection. However, the complex and somewhat disparate results of some of these trials have highlighted the need for effective integration of biomedical and behavioral sciences in the design and implementation of any future intervention trial. Integrating behavioral and biomedical sciences will require appropriate behavioral theories that can be used in the context of biomedical clinical trials and multidisciplinary teams working together from the earliest stages of trial design through to completion. It is also clear that integration of behavioral science will be necessary to implement prevention at the population level and reverse the HIV epidemic.

  7. Scientists and the 3Rs: attitudes to animal use in biomedical research and the effect of mandatory training in laboratory animal science.

    Science.gov (United States)

    Franco, N H; Olsson, I A S

    2014-01-01

    The 3Rs principle of replacement, reduction, and refinement has increasingly been endorsed by legislators and regulatory bodies as the best approach to tackle the ethical dilemma presented by animal experimentation in which the potential benefits for humans stand against the costs borne by the animals. Even when animal use is tightly regulated and supervised, the individual researcher's responsibility is still decisive in the implementation of the 3Rs. Training in laboratory animal science (LAS) aims to raise researchers' awareness and increase their knowledge, but its effect on scientists' attitudes and practice has not so far been systematically assessed. Participants (n = 206) in eight LAS courses (following the Federation of European Laboratory Animal Science Associations category C recommendations) in Portugal were surveyed in a self-administered questionnaire during the course. Questions were related mainly to the 3Rs and their application, attitudes to animal use and the ethical review of animal experiments. One year later, all the respondents were asked to answer a similar questionnaire (57% response rate) with added self-evaluation questions on the impact of training. Our results suggest that the course is effective in promoting awareness and increasing knowledge of the 3Rs, particularly with regard to refinement. However, participation in the course did not change perceptions on the current and future needs for animal use in research.

  8. Document Exploration and Automatic Knowledge Extraction for Unstructured Biomedical Text

    Science.gov (United States)

    Chu, S.; Totaro, G.; Doshi, N.; Thapar, S.; Mattmann, C. A.; Ramirez, P.

    2015-12-01

    We describe our work on building a web-browser based document reader with built-in exploration tool and automatic concept extraction of medical entities for biomedical text. Vast amounts of biomedical information are offered in unstructured text form through scientific publications and R&D reports. Utilizing text mining can help us to mine information and extract relevant knowledge from a plethora of biomedical text. The ability to employ such technologies to aid researchers in coping with information overload is greatly desirable. In recent years, there has been an increased interest in automatic biomedical concept extraction [1, 2] and intelligent PDF reader tools with the ability to search on content and find related articles [3]. Such reader tools are typically desktop applications and are limited to specific platforms. Our goal is to provide researchers with a simple tool to aid them in finding, reading, and exploring documents. Thus, we propose a web-based document explorer, which we called Shangri-Docs, which combines a document reader with automatic concept extraction and highlighting of relevant terms. Shangri-Docsalso provides the ability to evaluate a wide variety of document formats (e.g. PDF, Words, PPT, text, etc.) and to exploit the linked nature of the Web and personal content by performing searches on content from public sites (e.g. Wikipedia, PubMed) and private cataloged databases simultaneously. Shangri-Docsutilizes Apache cTAKES (clinical Text Analysis and Knowledge Extraction System) [4] and Unified Medical Language System (UMLS) to automatically identify and highlight terms and concepts, such as specific symptoms, diseases, drugs, and anatomical sites, mentioned in the text. cTAKES was originally designed specially to extract information from clinical medical records. Our investigation leads us to extend the automatic knowledge extraction process of cTAKES for biomedical research domain by improving the ontology guided information extraction

  9. The Present State and Future Perspective of Biomedical Engineering in Japan

    Science.gov (United States)

    2007-11-02

    The Present State and Future Perspective of Biomedical Engineering in Japan Shunsuke Sato (Osaka University, Graduate School of Engineering...21st century is a century of life sciences. Biomedical engineering is a field of integrated science and biotechnology, a paradigm where the basic... biomedical engineering and technological development in Japan. The number of members of the society was 900 at the time of establishment, but has

  10. Conception of Pharmacological Knowledge and Needs Amongst Nigerian Medical Students at Lagos State University College of Medicine: Implication for Future Biomedical Science in Africa.

    Science.gov (United States)

    Agaga, Luther Agbonyegbeni; John, Theresa Adebola

    2016-08-30

    In Nigeria, medical students are trained in more didactic environments than their counterparts in researchintensive academic medical centers. Their conception of pharmacology was thus sought. Students who are taking/have takenthe medical pharmacology course completed an 18-question survey within 10min by marking one/more choices fromalternatives. Instructions were: "Dear Participant, Please treat as confidential, give your true view, avoid influences, avoidcrosstalk, return survey promptly." Out of 301 students, 188 (62.46%) participated. Simple statistics showed: 61.3%respondents associated pharmacology with medicine, 24.9% with science, 16.8 % with industry, and 11.1% with government;32.8% want to know clinical pharmacology, 7.1% basic pharmacology, 6.7% pharmacotherapy, and 34.2% want a blend ofall three; 57.8% want to know clinical uses of drugs, 44.8% mechanisms of action, 44.4% side effects, and 31.1% differentdrugs in a group; 45.8% prefer to study lecturers' notes, 26.7% textbooks, 9.8% the Internet, and 2.7% journals; 46.7% usestandard textbooks, 11.5% revision texts, 2.66% advanced texts, and 8.4% no textbook; 40.4% study pharmacology to beable to treat patients, 39.1% to complete the requirements for MBBS degree, 8.9% to know this interesting subject, and 3.1%to make money. Respondents preferring aspects of pharmacology were: 42.7, 16, 16, and 10 (%) respectively for mechanismsof action, pharmacokinetics, side effects, and drug lists. Medical students' conception and need for pharmacology werebased on MBBS degree requirements; they lacked knowledge/interest in pharmacology as a science and may not be thepotential trusts for Africa's future pharmacology.

  11. Optimization and Data Analysis in Biomedical Informatics

    CERN Document Server

    Pardalos, Panos M; Xanthopoulos, Petros

    2012-01-01

    This volume covers some of the topics that are related to the rapidly growing field of biomedical informatics. In June 11-12, 2010 a workshop entitled 'Optimization and Data Analysis in Biomedical Informatics' was organized at The Fields Institute. Following this event invited contributions were gathered based on the talks presented at the workshop, and additional invited chapters were chosen from world's leading experts. In this publication, the authors share their expertise in the form of state-of-the-art research and review chapters, bringing together researchers from different disciplines

  12. Introducing the B I P (Biomedical Instrumentation Package). Many Important Electronic Functions in One Instrument.

    Science.gov (United States)

    Biomedical Interdisciplinary Curriculum Project, Berkeley, CA.

    Described are the use and purposes of the Biomedical Instrumentation Package (BIP) in science classrooms. Science activities are suggested and equipment use is described. A sample laboratory activity, which includes materials, procedure, and discussion, is provided. (SA)

  13. Camera systems in human motion analysis for biomedical applications

    Science.gov (United States)

    Chin, Lim Chee; Basah, Shafriza Nisha; Yaacob, Sazali; Juan, Yeap Ewe; Kadir, Aida Khairunnisaa Ab.

    2015-05-01

    Human Motion Analysis (HMA) system has been one of the major interests among researchers in the field of computer vision, artificial intelligence and biomedical engineering and sciences. This is due to its wide and promising biomedical applications, namely, bio-instrumentation for human computer interfacing and surveillance system for monitoring human behaviour as well as analysis of biomedical signal and image processing for diagnosis and rehabilitation applications. This paper provides an extensive review of the camera system of HMA, its taxonomy, including camera types, camera calibration and camera configuration. The review focused on evaluating the camera system consideration of the HMA system specifically for biomedical applications. This review is important as it provides guidelines and recommendation for researchers and practitioners in selecting a camera system of the HMA system for biomedical applications.

  14. Lead Agency Responsibilities to Keep Informed of Personnel Needs in the Food and Agricultural Sciences are not being Fully Met.

    Science.gov (United States)

    1981-12-28

    managers told us that various experiences in hiring and retaining personnel can be attributed to several causes, such as the degree of technology needed...General Foods Corp. - processors of packaged grocery products Hershey Foods Corp. - chocolates and confectionary products and pasta International...Placement Service National Academy of Sciences National Institutes of Health National Science Foundation Office of Technology Assessment Rockefeller

  15. Industry careers for the biomedical engineer.

    Science.gov (United States)

    Munzner, Robert F

    2004-01-01

    This year's conference theme is "linkages for innovation in biomedicine." Biomedical engineers, especially those transitioning their career from academic study into medical device industry, will play a critical role in converting the fruits of scientific research into the reality of modern medical devices. This special session is organized to help biomedical engineers to achieve their career goals more effectively. Participants will have opportunities to hear from and interact with leading industrial experts on many issues. These may include but not limited to 1) career paths for biomedical engineers (industrial, academic, or federal; technical vs. managerial track; small start-up or large established companies); 2) unique design challenges and regulatory requirements in medical device development; 3) aspects of a successful biomedical engineering job candidate (such as resume, interview, follow-up). Suggestions for other topics are welcome and should be directed to xkong@ieee.org The distinguished panelists include: Xuan Kong, Ph.D., VP of Research, NEUROMetrix Inc, Waltham, MA Robert F. Munzner, Ph.D., Medical Device Consultant, Doctor Device, Herndon, VA Glen McLaughlin, Ph.D., VP of Engineering and CTO, Zonare Medical System Inc., Mountain View, CA Grace Bartoo, Ph.D., RAC, General Manager, Decus Biomedical LLC San Carlos, CA.

  16. Biomedical enhancements as justice.

    Science.gov (United States)

    Nam, Jeesoo

    2015-02-01

    Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie moral obligation to use these new developments for the end goal of promoting social justice. In terms of both range and magnitude, the use of biomedical enhancements will mark a radical advance in how we compensate the most disadvantaged members of society.

  17. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 6, is a collection of papers that discusses the role of integrated electronics in medical systems and the usage of biological mathematical models in biological systems. Other papers deal with the health care systems, the problems and methods of approach toward rehabilitation, as well as the future of biomedical engineering. One paper discusses the use of system identification as it applies to biological systems to estimate the values of a number of parameters (for example, resistance, diffusion coefficients) by indirect means. More particularly, the i

  18. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 5, is a collection of papers that deals with application of the principles and practices of engineering to basic and applied biomedical research, development, and the delivery of health care. The papers also describe breakthroughs in health improvements, as well as basic research that have been accomplished through clinical applications. One paper examines engineering principles and practices that can be applied in developing therapeutic systems by a controlled delivery system in drug dosage. Another paper examines the physiological and materials vari

  19. Biomedical implantable microelectronics.

    Science.gov (United States)

    Meindl, J D

    1980-10-17

    Innovative applications of microelectronics in new biomedical implantable instruments offer a singular opportunity for advances in medical research and practice because of two salient factors: (i) beyond all other types of biomedical instruments, implants exploit fully the inherent technical advantages--complex functional capability, high reliability, lower power drain, small size and weight-of microelectronics, and (ii) implants bring microelectronics into intimate association with biological systems. The combination of these two factors enables otherwise impossible new experiments to be conducted and new paostheses developed that will improve the quality of human life.

  20. Ethics in biomedical engineering.

    Science.gov (United States)

    Morsy, Ahmed; Flexman, Jennifer

    2008-01-01

    This session focuses on a number of aspects of the subject of Ethics in Biomedical Engineering. The session starts by providing a case study of a company that manufactures artificial heart valves where the valves were failing at an unexpected rate. The case study focuses on Biomedical Engineers working at the company and how their education and training did not prepare them to deal properly with such situation. The second part of the session highlights the need to learn about various ethics rules and policies regulating research involving human or animal subjects.

  1. New ethical challenges in science and technology

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-08-31

    The published research features some of the nation's leading scientists and engineers, as well as science policy experts, and discusses a wide range of issues and topics. These include the economic and social pressure impacting biomedical research, the impossibility of predicting all the behaviors of increasingly complex, engineered systems, a look at the new federal guidelines for misconduct and new wrinkles on faculty conflicts of interest.

  2. Keep Abreast of Important Scientific Developments in China With the Leading Journal From China Science in China

    Institute of Scientific and Technical Information of China (English)

    1995-01-01

    Science in China (in English) with a history of 45 years is a comprehensive academicjournal of natural sciences sponsored by the Chinese Academy of Sciences. It is themost widely read scientific research journal in China and is i’ecognized as the mostauthoritative source of reference for current important development in scientific re-search in China. Papers carried in the journal are vigorously refereed by the mosthighly-esteemed scientists in China today "ensuring that only the papers of the higheststandard and quality are published.

  3. Facilitating biomedical researchers' interrogation of electronic health record data: Ideas from outside of biomedical informatics.

    Science.gov (United States)

    Hruby, Gregory W; Matsoukas, Konstantina; Cimino, James J; Weng, Chunhua

    2016-04-01

    Electronic health records (EHR) are a vital data resource for research uses, including cohort identification, phenotyping, pharmacovigilance, and public health surveillance. To realize the promise of EHR data for accelerating clinical research, it is imperative to enable efficient and autonomous EHR data interrogation by end users such as biomedical researchers. This paper surveys state-of-art approaches and key methodological considerations to this purpose. We adapted a previously published conceptual framework for interactive information retrieval, which defines three entities: user, channel, and source, by elaborating on channels for query formulation in the context of facilitating end users to interrogate EHR data. We show the current progress in biomedical informatics mainly lies in support for query execution and information modeling, primarily due to emphases on infrastructure development for data integration and data access via self-service query tools, but has neglected user support needed during iteratively query formulation processes, which can be costly and error-prone. In contrast, the information science literature has offered elaborate theories and methods for user modeling and query formulation support. The two bodies of literature are complementary, implying opportunities for cross-disciplinary idea exchange. On this basis, we outline the directions for future informatics research to improve our understanding of user needs and requirements for facilitating autonomous interrogation of EHR data by biomedical researchers. We suggest that cross-disciplinary translational research between biomedical informatics and information science can benefit our research in facilitating efficient data access in life sciences.

  4. Inorganic nanolayers: structure, preparation, and biomedical applications

    Science.gov (United States)

    Saifullah, Bullo; Hussein, Mohd Zobir B

    2015-01-01

    Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging. PMID:26366081

  5. Inorganic nanolayers: structure, preparation, and biomedical applications.

    Science.gov (United States)

    Saifullah, Bullo; Hussein, Mohd Zobir B

    2015-01-01

    Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

  6. Biomedical Engineering in Modern Society

    Science.gov (United States)

    Attinger, E. O.

    1971-01-01

    Considers definition of biomedical engineering (BME) and how biomedical engineers should be trained. State of the art descriptions of BME and BME education are followed by a brief look at the future of BME. (TS)

  7. Anatomy for Biomedical Engineers

    Science.gov (United States)

    Carmichael, Stephen W.; Robb, Richard A.

    2008-01-01

    There is a perceived need for anatomy instruction for graduate students enrolled in a biomedical engineering program. This appeared especially important for students interested in and using medical images. These students typically did not have a strong background in biology. The authors arranged for students to dissect regions of the body that…

  8. Investigating the teaching methodology of English for science and technology in the major of biomedical engineering%生物医学工程专业《科技英语》教学方法探讨

    Institute of Scientific and Technical Information of China (English)

    景达; 罗二平; 谢康宁; 申广浩; 汤池; 吴小明; 郭伟; 刘娟; 佟世超

    2015-01-01

    科技英语是科技工作者进行学术交流的语言媒介,其表述具有简明、准确、客观和易懂的特点。《科技英语》课程是学生继大学公共英语学习之后,夯实英语基础知识、提高专业英语水平和应用技能的一个重要环节。实践中针对从事生物医学工程专业开展的科技英语教学,结合了本专业”医工结合“的学科特点,总结出一套以兴趣驱动、输出牵引、由点及面为主体的交互式教学思路。%English for science and technology (EST) is the language medium for academic communication among scientists and technologists. The expression of EST is characterized by concise-ness, correctness, objectiveness and understandability. The EST course is regarded as a key process for the undergraduate students to reinforce the English foundation and improve the capacity of English application after their College English study. In this paper, the authors introduced an interest-motivated, output-dominated, snowballing and interactive teaching strategy, according to the accumulated experi-ence of EST teaching in the past few years coupled with the unique medicine-engineering combined characteristics for the major of biomedical engineering.

  9. Biomedical signals, imaging, and informatics

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Signals, Imaging, and Informatics, the third volume of the handbook, presents material from respected scientists with diverse backgrounds in biosignal processing, medical imaging, infrared imaging, and medical informatics.More than three dozen specific topics are examined, including biomedical s

  10. World-leading science with SPIRou - the nIR spectropolarimeter / high-precision velocimeter for CFHT

    CERN Document Server

    Delfosse, X; Kouach, D; Hébrard, G; Doyon, R; Artigau, E; Bouchy, F; Boisse, I; Brun, A S; Hennebelle, P; Widemann, T; Bouvier, J; Bonfils, X; Morin, J; Moutou, C; Pepe, F; Udry, S; Nascimento, J -D do; Alencar, S H P; Castilho, B V; Martioli, E; Wang, S Y; Figueira, P; Santos, N C

    2013-01-01

    SPIRou is a near-infrared (nIR) spectropolarimeter / velocimeter proposed as a new-generation instrument for CFHT. SPIRou aims in particular at becoming world-leader on two forefront science topics, (i) the quest for habitable Earth-like planets around very- low-mass stars, and (ii) the study of low-mass star and planet formation in the presence of magnetic fields. In addition to these two main goals, SPIRou will be able to tackle many key programs, from weather patterns on brown dwarf to solar-system planet atmospheres, to dynamo processes in fully-convective bodies and planet habitability. The science programs that SPIRou proposes to tackle are forefront (identified as first priorities by most research agencies worldwide), ambitious (competitive and complementary with science programs carried out on much larger facilities, such as ALMA and JWST) and timely (ideally phased with complementary space missions like TESS and CHEOPS). SPIRou is designed to carry out its science mission with maximum efficiency and ...

  11. Classroom Use of Narrative and Documentary Film Leads to an Enhanced Understanding of Cultural Diversity and Ethics in Science

    Science.gov (United States)

    González, Edward L. F.; Lewis, C. Thomas; Slayback-Barry, Denise; Yost, Robert W.

    2016-01-01

    For a first-year seminar, Windows on Science, the authors developed a cooperative learning activity around film designed to meet two of the campus-wide Principles of Undergraduate Learning. The teaching method utilizes the power of storytelling by screening narrative and documentary films. In the process, the methodology helps students to realize…

  12. Biomedical engineering: A platform for research and innovation in ultrasound

    Science.gov (United States)

    Holland, Christy K.

    2001-05-01

    An undergraduate or graduate degree in biomedical engineering prepares students to solve problems at the interface between engineering and medicine. Biomedical engineering encompasses evolving areas such as advanced medical imaging for diagnosis and treatment of disease, tissue engineering for designing and manufacturing biological implants for damaged or diseased tissues and organs, and bioinformatics for determining which genes play a major role in health and disease. Biomedical engineering academic programs produce graduates with the ability to pursue successful careers in the biomedical device industry or to obtain advanced degrees leading to careers in biomedical engineering research, medicine, law or business. Biomedical engineering majors take courses in biology, anatomy, physics, chemistry, engineering, mathematics and medical product design and value life-long learning. Students learn to work effectively in interdisciplinary teams comprised of individuals with diverse social, cultural and technical backgrounds. Biomedical engineering is becoming increasingly important in imaging and image-guided research. Some examples of innovative ultrasound technology under development are ultrasound devices to accelerate the dissolution of blood clots, advanced surgical instruments with ultrasound guidance and ultrasound contrast agents for targeted drug delivery. Biomedical engineering is a great career choice for technically minded individuals who endeavor to work on applied problems that are medically relevant.

  13. Biomedical engineering: A platform for research and innovation in ultrasound

    Science.gov (United States)

    Holland, Christy K.

    2004-05-01

    An undergraduate or graduate degree in biomedical engineering prepares students to solve problems at the interface between engineering and medicine. Biomedical engineering encompasses evolving areas such as advanced medical imaging for diagnosis and treatment of disease, tissue engineering for designing and manufacturing biological implants for damaged or diseased tissues and organs, and bioinformatics for determining which genes play a major role in health and disease. Biomedical engineering academic programs produce graduates with the ability to pursue successful careers in the biomedical device industry or to obtain advanced degrees leading to careers in biomedical engineering research, medicine, law or business. Biomedical engineering majors take courses in biology, anatomy, physics, chemistry, engineering, mathematics and medical product design and value life-long learning. Students learn to work effectively in interdisciplinary teams comprised of individuals with diverse social, cultural and technical backgrounds. Biomedical engineering is becoming increasingly important in imaging and image-guided research. Some examples of innovative ultrasound technology under development are ultrasound devices to accelerate the dissolution of blood clots, advanced surgical instruments with ultrasound guidance and ultrasound contrast agents for targeted drug delivery. Biomedical engineering is a great career choice for technically minded individuals who endeavor to work on applied problems that are medically relevant.

  14. Optical Polarizationin Biomedical Applications

    CERN Document Server

    Tuchin, Valery V; Zimnyakov, Dmitry A

    2006-01-01

    Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.

  15. Functional supramolecular polymers for biomedical applications.

    Science.gov (United States)

    Dong, Ruijiao; Zhou, Yongfeng; Huang, Xiaohua; Zhu, Xinyuan; Lu, Yunfeng; Shen, Jian

    2015-01-21

    As a novel class of dynamic and non-covalent polymers, supramolecular polymers not only display specific structural and physicochemical properties, but also have the ability to undergo reversible changes of structure, shape, and function in response to diverse external stimuli, making them promising candidates for widespread applications ranging from academic research to industrial fields. By an elegant combination of dynamic/reversible structures with exceptional functions, functional supramolecular polymers are attracting increasing attention in various fields. In particular, functional supramolecular polymers offer several unique advantages, including inherent degradable polymer backbones, smart responsiveness to various biological stimuli, and the ease for the incorporation of multiple biofunctionalities (e.g., targeting and bioactivity), thereby showing great potential for a wide range of applications in the biomedical field. In this Review, the trends and representative achievements in the design and synthesis of supramolecular polymers with specific functions are summarized, as well as their wide-ranging biomedical applications such as drug delivery, gene transfection, protein delivery, bio-imaging and diagnosis, tissue engineering, and biomimetic chemistry. These achievements further inspire persistent efforts in an emerging interdisciplin-ary research area of supramolecular chemistry, polymer science, material science, biomedical engineering, and nanotechnology.

  16. Multilingual biomedical dictionary.

    Science.gov (United States)

    Daumke, Philipp; Markó, Kornél; Poprat, Michael; Schulz, Stefan

    2005-01-01

    We present a unique technique to create a multilingual biomedical dictionary, based on a methodology called Morpho-Semantic indexing. Our approach closes a gap caused by the absence of free available multilingual medical dictionaries and the lack of accuracy of non-medical electronic translation tools. We first explain the underlying technology followed by a description of the dictionary interface, which makes use of a multilingual subword thesaurus and of statistical information from a domain-specific, multilingual corpus.

  17. Adaptive Biomedical Innovation.

    Science.gov (United States)

    Honig, P K; Hirsch, G

    2016-12-01

    Adaptive Biomedical Innovation (ABI) is a multistakeholder approach to product and process innovation aimed at accelerating the delivery of clinical value to patients and society. ABI offers the opportunity to transcend the fragmentation and linearity of decision-making in our current model and create a common collaborative framework that optimizes the benefit and access of new medicines for patients as well as creating a more sustainable innovation ecosystem.

  18. [Biomedical activity of biosurfactants].

    Science.gov (United States)

    Krasowska, Anna

    2010-07-23

    Biosurfactants, amphiphilic compounds, synthesized by microorganisms have surface, antimicrobial and antitumor properties. Biosurfactants prevent adhesion and biofilms formation by bacteria and fungi on various surfaces. For many years microbial surfactants are used as antibiotics with board spectrum of activity against microorganisms. Biosurfactants act as antiviral compounds and their antitumor activities are mediated through induction of apoptosis. This work presents the current state of knowledge related to biomedical activity of biosurfactants.

  19. Biomedical accelerator mass spectrometry

    Science.gov (United States)

    Freeman, Stewart P. H. T.; Vogel, John S.

    1995-05-01

    Ultrasensitive SIMS with accelerator based spectrometers has recently begun to be applied to biomedical problems. Certain very long-lived radioisotopes of very low natural abundances can be used to trace metabolism at environmental dose levels ( [greater-or-equal, slanted] z mol in mg samples). 14C in particular can be employed to label a myriad of compounds. Competing technologies typically require super environmental doses that can perturb the system under investigation, followed by uncertain extrapolation to the low dose regime. 41Ca and 26Al are also used as elemental tracers. Given the sensitivity of the accelerator method, care must be taken to avoid contamination of the mass spectrometer and the apparatus employed in prior sample handling including chemical separation. This infant field comprises the efforts of a dozen accelerator laboratories. The Center for Accelerator Mass Spectrometry has been particularly active. In addition to collaborating with groups further afield, we are researching the kinematics and binding of genotoxins in-house, and we support innovative uses of our capability in the disciplines of chemistry, pharmacology, nutrition and physiology within the University of California. The field can be expected to grow further given the numerous potential applications and the efforts of several groups and companies to integrate more the accelerator technology into biomedical research programs; the development of miniaturized accelerator systems and ion sources capable of interfacing to conventional HPLC and GMC, etc. apparatus for complementary chemical analysis is anticipated for biomedical laboratories.

  20. Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?

    Science.gov (United States)

    Poland, Gregory A; Kennedy, Richard B; Ovsyannikova, Inna G

    2011-12-01

    As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a current major barrier in vaccinology-that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper-variable viruses. While our laboratory's data and thinking (and hence also for this paper) has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines) may be appropriate.

  1. Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery?

    Directory of Open Access Journals (Sweden)

    Gregory A Poland

    2011-12-01

    Full Text Available As is apparent in many fields of science and medicine, the new biology, and particularly new high-throughput genetic sequencing and transcriptomic and epigenetic technologies, are radically altering our understanding and views of science. In this article, we make the case that while mostly ignored thus far in the vaccine field, these changes will revolutionize vaccinology from development to manufacture to administration. Such advances will address a current major barrier in vaccinology-that of empiric vaccine discovery and development, and the subsequent low yield of viable vaccine candidates, particularly for hyper-variable viruses. While our laboratory's data and thinking (and hence also for this paper has been directed toward viruses and viral vaccines, generalization to other pathogens and disease entities (i.e., anti-cancer vaccines may be appropriate.

  2. Integrating science and business models of sustainability for environmentally-challenging industries such as secondary lead smelters: a systematic review and analysis of findings.

    Science.gov (United States)

    Genaidy, A M; Sequeira, R; Tolaymat, T; Kohler, J; Wallace, S; Rinder, M

    2010-09-01

    Secondary lead smelters (SLS) represent an environmentally-challenging industry as they deal with toxic substances posing potential threats to both human and environmental health, consequently, they operate under strict government regulations. Such challenges have resulted in the significant reduction of SLS plants in the last three decades. In addition, the domestic recycling of lead has been on a steep decline in the past 10 years as the amount of lead recovered has remained virtually unchanged while consumption has increased. Therefore, one may wonder whether sustainable development can be achieved among SLS. The primary objective of this study was to determine whether a roadmap for sustainable development can be established for SLS. The following aims were established in support of the study objective: (1) to conduct a systematic review and an analysis of models of sustainable systems with a particular emphasis on SLS; (2) to document the challenges for the U.S. secondary lead smelting industry; and (3) to explore practices and concepts which act as vehicles for SLS on the road to sustainable development. An evidence-based methodology was adopted to achieve the study objective. A comprehensive electronic search was conducted to implement the aforementioned specific aims. Inclusion criteria were established to filter out irrelevant scientific papers and reports. The relevant articles were closely scrutinized and appraised to extract the required information and data for the possible development of a sustainable roadmap. The search process yielded a number of research articles which were utilized in the systematic review. Two types of models emerged: management/business and science/mathematical models. Although the management/business models explored actions to achieve sustainable growth in the industrial enterprise, science/mathematical models attempted to explain the sustainable behaviors and properties aiming at predominantly ecosystem management. As such

  3. [The Chilean Association of Biomedical Journal Editors].

    Science.gov (United States)

    Reyes, H

    2001-01-01

    On September 29th, 2000, The Chilean Association of Biomedical Journal Editors was founded, sponsored by the "Comisión Nacional de Investigación Científica y Tecnológica (CONICYT)" (the Governmental Agency promoting and funding scientific research and technological development in Chile) and the "Sociedad Médica de Santiago" (Chilean Society of Internal Medicine). The Association adopted the goals of the World Association of Medical Editors (WAME) and therefore it will foster "cooperation and communication among Editors of Chilean biomedical journals; to improve editorial standards, to promote professionalism in medical editing through education, self-criticism and self-regulation; and to encourage research on the principles and practice of medical editing". Twenty nine journals covering a closely similar number of different biomedical sciences, medical specialties, veterinary, dentistry and nursing, became Founding Members of the Association. A Governing Board was elected: President: Humberto Reyes, M.D. (Editor, Revista Médica de Chile); Vice-President: Mariano del Sol, M.D. (Editor, Revista Chilena de Anatomía); Secretary: Anna María Prat (CONICYT); Councilors: Manuel Krauskopff, Ph.D. (Editor, Biological Research) and Maritza Rahal, M.D. (Editor, Revista de Otorrinolaringología y Cirugía de Cabeza y Cuello). The Association will organize a Symposium on Biomedical Journal Editing and will spread information stimulating Chilean biomedical journals to become indexed in international databases and in SciELO-Chile, the main Chilean scientific website (www.scielo.cl).

  4. Implantable biomedical microsystems design principles and applications

    CERN Document Server

    Bhunia, Swarup; Sawan, Mohamad

    2015-01-01

    Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body. This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each co

  5. Nanotechnologies for biomedical science and translational medicine.

    Science.gov (United States)

    Heath, James R

    2015-11-24

    In 2000 the United States launched the National Nanotechnology Initiative and, along with it, a well-defined set of goals for nanomedicine. This Perspective looks back at the progress made toward those goals, within the context of the changing landscape in biomedicine that has occurred over the past 15 years, and considers advances that are likely to occur during the next decade. In particular, nanotechnologies for health-related genomics and single-cell biology, inorganic and organic nanoparticles for biomedicine, and wearable nanotechnologies for wellness monitoring are briefly covered.

  6. Handbook of photonics for biomedical science

    CERN Document Server

    Tuchin, Valery V

    2010-01-01

    Many of the chapters are written by leaders in their field and thus provide both good foundational descriptions as well as up-to-date accounts of the state of the field. … the book does well throughout: providing a better than skin-deep introduction to a subject, focusing on the core issues within a field and providing references to enable more detailed investigation. … It brings together much of the most important literature into an easily accessible form. Written by leaders in their respective fields, this book would be a valuable addition to the collection of researchers, engineers and c

  7. Light-actuated microrobots for biomedical science

    DEFF Research Database (Denmark)

    Glückstad, Jesper; Villangca, Mark Jayson; Palima, Darwin Z.

    2017-01-01

    Light can be used to fabricate, handle, power, and actuate microrobotics functionalities, such as the loading and unloading of micro-cargo, showing promise for drug delivery and biological-testing applications....

  8. Biomedical research applications of electromagnetically separated enriched stable isotopes

    Science.gov (United States)

    Lambrecht, R. M.

    The current and projected annual requirements through 1985 for stable isotopes enriched by electromagnetic separation methods were reviewed for applications in various types of biomedical research: (1) medical radiosiotope production, labeled compounds, and potential radio-pharmaceuticals; (2) nutrition, food science, and pharmacology: (3) metallobiochemistry and environmental toxicology; (4) nuclear magnetic resonance, electron paramagnetic resonance, and moessbauer spectroscopy in biochemical, biophysical, and biomedical research; and (5) miscellaneous advances in radioactive and nonradioactive tracer technology. Radioisotopes available from commercial sources or routinely used in clinical nuclear medicine were excluded. Current requirements for enriched stable isotopes in biomedical research are not being satisfied. Severe shortages exist for Mg 26, Ca 43, Zn 70, Se 76, Se 77, Se 78, Pd 102, Cd 111, Cd 113, and Os 190. Many interesting and potentially important investigations in biomedical research require small quantities of specific elements at high isotopic enrichments.

  9. Titanium nanostructures for biomedical applications

    Science.gov (United States)

    Kulkarni, M.; Mazare, A.; Gongadze, E.; Perutkova, Š.; Kralj-Iglič, V.; Milošev, I.; Schmuki, P.; Iglič, A.; Mozetič, M.

    2015-02-01

    Titanium and titanium alloys exhibit a unique combination of strength and biocompatibility, which enables their use in medical applications and accounts for their extensive use as implant materials in the last 50 years. Currently, a large amount of research is being carried out in order to determine the optimal surface topography for use in bioapplications, and thus the emphasis is on nanotechnology for biomedical applications. It was recently shown that titanium implants with rough surface topography and free energy increase osteoblast adhesion, maturation and subsequent bone formation. Furthermore, the adhesion of different cell lines to the surface of titanium implants is influenced by the surface characteristics of titanium; namely topography, charge distribution and chemistry. The present review article focuses on the specific nanotopography of titanium, i.e. titanium dioxide (TiO2) nanotubes, using a simple electrochemical anodisation method of the metallic substrate and other processes such as the hydrothermal or sol-gel template. One key advantage of using TiO2 nanotubes in cell interactions is based on the fact that TiO2 nanotube morphology is correlated with cell adhesion, spreading, growth and differentiation of mesenchymal stem cells, which were shown to be maximally induced on smaller diameter nanotubes (15 nm), but hindered on larger diameter (100 nm) tubes, leading to cell death and apoptosis. Research has supported the significance of nanotopography (TiO2 nanotube diameter) in cell adhesion and cell growth, and suggests that the mechanics of focal adhesion formation are similar among different cell types. As such, the present review will focus on perhaps the most spectacular and surprising one-dimensional structures and their unique biomedical applications for increased osseointegration, protein interaction and antibacterial properties.

  10. BIMS: Biomedical Information Management System

    OpenAIRE

    Mora, Oscar; Bisbal, Jesús

    2013-01-01

    In this paper, we present BIMS (Biomedical Information Management System). BIMS is a software architecture designed to provide a flexible computational framework to manage the information needs of a wide range of biomedical research projects. The main goal is to facilitate the clinicians' job in data entry, and researcher's tasks in data management, in high data quality biomedical research projects. The BIMS architecture has been designed following the two-level modeling paradigm, a promising...

  11. Biomedical Sensors and Instruments

    CERN Document Server

    Tagawa, Tatsuo

    2011-01-01

    The living body is a difficult object to measure: accurate measurements of physiological signals require sensors and instruments capable of high specificity and selectivity that do not interfere with the systems under study. As a result, detailed knowledge of sensor and instrument properties is required to be able to select the "best" sensor from one of the many designed to meet these challenges. From the underlying principles to practical applications, this updated edition of Biomedical Sensors and Instruments provides an easy-to-understand introduction to the various kinds of biome

  12. Principles of Biomedical Engineering

    CERN Document Server

    Madihally, Sundararajan V

    2010-01-01

    Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Supported with over 145 illustrations, the book discusses bioelectrical systems, mechanical analysis of biological tissues and organs, biomaterial selection, compartmental modeling, and biomedical instrumentation. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics.Structured as a complete text for students with some engineering background, the book also makes a valuable refere

  13. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1973-01-01

    Advances in Biomedical Engineering, Volume 3, is a collection of papers that discusses circulatory system models, linguistics in computer usage, and clinical applications on patient monitoring. One paper describes the use of comparative models of overall circulatory mechanics that include models of the cardiac pump, of the vascular systems, and of the overall systems behavior. Another paper describes a model in processing medical language data that employs an explicit semantic structure, becoming the basis for the computer-based, artificial intelligence of the system. One paper cites studies b

  14. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1974-01-01

    Advances in Biomedical Engineering, Volume 4, is a collection of papers that deals with gas chromatography, mass spectroscopy and the analysis of minute samples, as well as the role of the government in regulating the production, usage, safety, and efficacy of medical devices. One paper reviews the use of mass spectrometry and computer technology in relation to gas-phase analytical methods based on gas chromatograph-mass spectrometer instruments and gas chromatograph-mass spectrometer-computer analytical systems. Many health practitioners, government and private health agencies, the legal prof

  15. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  16. Statistics in biomedical research

    Directory of Open Access Journals (Sweden)

    González-Manteiga, Wenceslao

    2007-06-01

    Full Text Available The discipline of biostatistics is nowadays a fundamental scientific component of biomedical, public health and health services research. Traditional and emerging areas of application include clinical trials research, observational studies, physiology, imaging, and genomics. The present article reviews the current situation of biostatistics, considering the statistical methods traditionally used in biomedical research, as well as the ongoing development of new methods in response to the new problems arising in medicine. Clearly, the successful application of statistics in biomedical research requires appropriate training of biostatisticians. This training should aim to give due consideration to emerging new areas of statistics, while at the same time retaining full coverage of the fundamentals of statistical theory and methodology. In addition, it is important that students of biostatistics receive formal training in relevant biomedical disciplines, such as epidemiology, clinical trials, molecular biology, genetics, and neuroscience.La Bioestadística es hoy en día una componente científica fundamental de la investigación en Biomedicina, salud pública y servicios de salud. Las áreas tradicionales y emergentes de aplicación incluyen ensayos clínicos, estudios observacionales, fisología, imágenes, y genómica. Este artículo repasa la situación actual de la Bioestadística, considerando los métodos estadísticos usados tradicionalmente en investigación biomédica, así como los recientes desarrollos de nuevos métodos, para dar respuesta a los nuevos problemas que surgen en Medicina. Obviamente, la aplicación fructífera de la estadística en investigación biomédica exige una formación adecuada de los bioestadísticos, formación que debería tener en cuenta las áreas emergentes en estadística, cubriendo al mismo tiempo los fundamentos de la teoría estadística y su metodología. Es importante, además, que los estudiantes de

  17. Biomedical problems of hydrotechnical construction

    Energy Technology Data Exchange (ETDEWEB)

    Avakyan, A.B.; El' piner, L.I.; Delitsyn, V.M.

    1988-04-01

    The effect of hydrotechnical and water-management construction on the living conditions and health of the population was examined. The results were used to develop the scientific bases and methods of biomedical predictions in several stages: evaluating biomedical conditions in territories where a change is expected, and constructing biomedical prediction proper of the effect of hydrotechnical constructions. The development of the indicated predictions make it possible to include measures on intensifying the positive and preventing or abating undesired effects on the biomedical situation when designing hydrotechnical and water-management construction.

  18. Measurements and Evaluation of Nuclear Reaction Cross Sections Leading to Various Practical Applications in Science and Technology

    Energy Technology Data Exchange (ETDEWEB)

    Khandaker, Mayeen Uddin; Lee, Young Ouk; Cho, Young Sik

    2008-07-15

    This report contains the measurements and evaluation of production cross sections of some medically and technologically important radionuclides over the energy range 1-40 MeV by using a conventional stacked-foil activation technique combined with high purity germanium (HPGe) -ray spectrometry. The irradiations were done by using the external beam line of the MC-50 cyclotron at the Korea Institute of Radiological and Medical Sciences (KIRAMS). The standard cross sections for monitor reactions were taken from IAEA web site. Integral yields for the investigated radionuclides were deduced using the measured cross-sections. Reported data were compared with the available literature data, theoretical calculations by the codes TALYS and ALICE-IPPE, and a good overall agreement among them was found.

  19. Role of Leading Programs in Doctoral Education: A New Type of Leadership Education in the Sciences at University of Hyogo, Japan

    Directory of Open Access Journals (Sweden)

    Maya Okamoto

    2015-01-01

    Full Text Available Fostering global leaders for the next generation is an important mission of universities. In Japan, Leading Programs in Doctoral Education (LP has been implemented in many graduate schools. The main goal of this program is to foster PhDs with deep specialization and peer leadership who will be able to compete well internationally. The Graduate School of Life Science, University of Hyogo is implementing a LP to foster global leaders using cutting-edge technology. They are also trying to create new evaluation criteria of human resource development with their corporate sponsors. The success of LP depends not only on how many graduates can play leading roles globally, but also how university staff can create a superior new evaluation criteria of human resource development and how much it can be shared with universities and industry. Development of students and graduates with a high level of ability takes time, thus it is important to consider the continuous development of LP.

  20. Biomedical applications of nisin.

    Science.gov (United States)

    Shin, J M; Gwak, J W; Kamarajan, P; Fenno, J C; Rickard, A H; Kapila, Y L

    2016-06-01

    Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin is classified as a Type A (I) lantibiotic that is synthesized from mRNA and the translated peptide contains several unusual amino acids due to post-translational modifications. Over the past few decades, nisin has been used widely as a food biopreservative. Since then, many natural and genetically modified variants of nisin have been identified and studied for their unique antimicrobial properties. Nisin is FDA approved and generally regarded as a safe peptide with recognized potential for clinical use. Over the past two decades the application of nisin has been extended to biomedical fields. Studies have reported that nisin can prevent the growth of drug-resistant bacterial strains, such as methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Enterococci and Clostridium difficile. Nisin has now been shown to have antimicrobial activity against both Gram-positive and Gram-negative disease-associated pathogens. Nisin has been reported to have anti-biofilm properties and can work synergistically in combination with conventional therapeutic drugs. In addition, like host-defence peptides, nisin may activate the adaptive immune response and have an immunomodulatory role. Increasing evidence indicates that nisin can influence the growth of tumours and exhibit selective cytotoxicity towards cancer cells. Collectively, the application of nisin has advanced beyond its role as a food biopreservative. Thus, this review will describe and compare studies on nisin and provide insight into its future biomedical applications.

  1. What Do I Want to Be with My PhD? The Roles of Personal Values and Structural Dynamics in Shaping the Career Interests of Recent Biomedical Science PhD Graduates

    Science.gov (United States)

    Gibbs, Kenneth D., Jr.; Griffin, Kimberly A.

    2013-01-01

    Interest in faculty careers decreases as graduate training progresses; however, the process underlying career-interest formation remains poorly defined. To better understand this process and whether/how it differs across social identity (i.e., race/ethnicity, gender), we conducted focus groups with 38 biomedical scientists who received PhDs…

  2. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  3. Environmental practices for biomedical research facilities.

    Science.gov (United States)

    Medlin, E L; Grupenhoff, J T

    2000-12-01

    As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement of for-profit companies and government agencies. The designation "facilities" includes all related buildings and grounds, "green auditing" of buildings and programs, purchasing of furnishings and sources, energy efficiency, and engineering services (lighting, heating, air conditioning), among other activities. The committee made a number of recommendations, including development of a national council for environmental stewardship in biomedical research, development of a system of green auditing of such research facilities, and creation of programs for sustainable building and use. In addition, the committee recommended extension of education and training programs for environmental stewardship, in cooperation with facilities managers, for all research administrators and researchers. These programs would focus especially on graduate fellows and other students, as well as on science labs at levels K--12.

  4. Training Multidisciplinary Biomedical Informatics Students: Three Years of Experience

    NARCIS (Netherlands)

    E.M. van Mulligen (Erik); M. Cases (Montserrat); K.M. Hettne (Kristina); E. Molero (Eva); M. Weeber (Marc); K.A. Robertson (Kevin); B. Oliva (Baldomero); G. de la Calle (Guillermo); V. Maojo (Victor)

    2008-01-01

    textabstractObjective: The European INFOBIOMED Network of Excellence1recognized that a successful education program in biomedical informatics should include not only traditional teaching activities in the basic sciences but also the development of skills for working in multidisciplinary teams. Desig

  5. Biomedical Engineering: A Compendium of Research Training Programs.

    Science.gov (United States)

    National Inst. of General Medical Sciences (NIH), Bethesda, MD.

    This document was prepared to provide a comprehensive view of the programs in biomedical engineering in existence in 1969. These programs are supported by the National Institute of General Medical Sciences and are located at 18 universities. This compendium provides information as to the intent and content of these programs from data provided by…

  6. Distributed Representation of Biomedical Words for Drug Repositioning

    OpenAIRE

    ゴー, ドゥク, ルー

    2016-01-01

    博士論文本文 以下に掲載:Journal of Biomedical Science and Engineering 9(1) pp.7-16 2016 January. Scientific Research Publishing Inc. 共著者:Duc Luu Ngo, Naoki Yamamoto, Vu Anh Tran, Ngoc Giang Nguyen, Dau Phan, Favorisen Rosyking Lumbanraja, Mamoru Kubo, Kenji Satou

  7. The panacea statistical toolbox of a biomedical peer reviewer.

    Science.gov (United States)

    Skaik, Younis

    2015-01-01

    The main role of a peer reviewer is to make judgments on the research articles by asking a number of questions to evaluate the quality of the research article. Statistics is a major part of any biomedical research article, and most reviewers gain their experiences in manuscript reviewing by undertaking it but not through an educational process. Therefore, reviewers of the biomedical journals normally do not have enough knowledge and skills to evaluate the validity of statistical methods used in biomedical research articles submitted for consideration. Hence, inappropriate statistical analysis in medical journals can lead to misleading conclusions and incorrect results. In this paper, the most common basic statistical guidelines are described that might be a road map to the biomedical reviewers. It is not meant for statisticians or medical editors who have special interest and expertise in statistical analysis.

  8. Professional Identification for Biomedical Engineers

    Science.gov (United States)

    Long, Francis M.

    1973-01-01

    Discusses four methods of professional identification in biomedical engineering including registration, certification, accreditation, and possible membership qualification of the societies. Indicates that the destiny of the biomedical engineer may be under the control of a new profession, neither the medical nor the engineering. (CC)

  9. Ethical considerations for biomedical scientists and engineers: issues for the rank and file.

    Science.gov (United States)

    Kwarteng, K B

    2000-01-01

    Biomedical science and engineering is inextricably linked with the fields of medicine and surgery. Yet, while physicians and surgeons, nurses, and other medical professionals receive instruction in ethics during their training and must abide by certain codes of ethics during their practice, those engaged in biomedical science and engineering typically receive no formal training in ethics. In fact, the little contact that many biomedical science and engineering professionals have with ethics occurs either when they participate in government-funded research or submit articles for publication in certain journals. Thus, there is a need for biomedical scientists and engineers as a group to become more aware of ethics. Moreover, recent advances in biomedical technology and the ever-increasing use of new devices virtually guarantee that biomedical science and engineering will become even more important in the future. Although they are rarely in direct contact with patients, biomedical scientists and engineers must become aware of ethics in order to be able to deal with the complex ethical issues that arise from our society's increasing reliance on biomedical technology. In this brief communication, the need for ethical awareness among workers in biomedical science and engineering is discussed in terms of certain conflicts that arise in the workaday world of the biomedical scientist in a complex, modern society. It is also recognized that inasmuch as workers in the many branches of bioengineering are not regulated like their counterparts in medicine and surgery, perhaps academic institutions and professional societies are best equipped to heighten ethical awareness among workers in this important field.

  10. Computational intelligence in biomedical imaging

    CERN Document Server

    2014-01-01

    This book provides a comprehensive overview of the state-of-the-art computational intelligence research and technologies in biomedical images with emphasis on biomedical decision making. Biomedical imaging offers useful information on patients’ medical conditions and clues to causes of their symptoms and diseases. Biomedical images, however, provide a large number of images which physicians must interpret. Therefore, computer aids are demanded and become indispensable in physicians’ decision making. This book discusses major technical advancements and research findings in the field of computational intelligence in biomedical imaging, for example, computational intelligence in computer-aided diagnosis for breast cancer, prostate cancer, and brain disease, in lung function analysis, and in radiation therapy. The book examines technologies and studies that have reached the practical level, and those technologies that are becoming available in clinical practices in hospitals rapidly such as computational inte...

  11. Student engagement in biomedical courses : studies in technology-enhanced seminar learning

    NARCIS (Netherlands)

    Bouwmeester, R.A.M.

    2016-01-01

    Academic medical and biomedical curricula are designed to educate future academics contributing to new developments in science, clinical practice and society. During undergraduate programs student training is typically focused on acquisition of knowledge and understanding of these interdisciplinary

  12. Biomedical applications of functionalized fullerene-based nanomaterials

    OpenAIRE

    Ranga Partha; Conyers, Jodie L.

    2009-01-01

    Ranga Partha, Jodie L ConyersCenter for Translational Injury Research, The University of Texas Health Science Center, Houston, TX 77030, USAAbstract: Since their discovery in 1985, fullerenes have been investigated extensively due to their unique physical and chemical properties. In recent years, studies on functionalized fullerenes for various applications in the field of biomedical sciences have seen a significant increase. The ultimate goal is towards employing these functionalized fullere...

  13. Checklists in biomedical publications

    Directory of Open Access Journals (Sweden)

    Pardal-Refoyo JL

    2013-12-01

    Full Text Available Introduction and objectives: the authors, reviewers, editors and readers must have specific tools that help them in the process of drafting, review, or reading the articles. Objective: to offer a summary of the major checklists for different types of biomedical research articles. Material and method: review literature and resources of the EQUATOR Network and adaptations in Spanish published by Medicina Clínica and Evidencias en Pediatría journals. Results: are the checklists elaborated by various working groups. (CONSORT and TREND, experimental studies for observational studies (STROBE, accuracy (STARD diagnostic studies, systematic reviews and meta-analyses (PRISMA and for studies to improve the quality (SQUIRE. Conclusions: the use of checklists help to improve the quality of articles and help to authors, reviewers, to the editor and readers in the development and understanding of the content.

  14. Biomedical applications of collagens.

    Science.gov (United States)

    Ramshaw, John A M

    2016-05-01

    Collagen-based biomedical materials have developed into important, clinically effective materials used in a range of devices that have gained wide acceptance. These devices come with collagen in various formats, including those based on stabilized natural tissues, those that are based on extracted and purified collagens, and designed composite, biosynthetic materials. Further knowledge on the structure and function of collagens has led to on-going developments and improvements. Among these developments has been the production of recombinant collagen materials that are well defined and are disease free. Most recently, a group of bacterial, non-animal collagens has emerged that may provide an excellent, novel source of collagen for use in biomaterials and other applications. These newer collagens are discussed in detail. They can be modified to direct their function, and they can be fabricated into various formats, including films and sponges, while solutions can also be adapted for use in surface coating technologies.

  15. MEMS biomedical implants

    Institute of Scientific and Technical Information of China (English)

    Tai Yuchong

    2012-01-01

    The field of micro-electro-mechanical systems (MEMS) has advanced tremendously for the last 20 years. Most commercially noticeably, the field has successfully advanced from pressure sensors to micro physical sensors, such as accelerometers and gyros, for handheld electronics application. In parallel, MEMS has also advanced into micro total analysis system(TAS) and/or lab-on-a-chip applications. This article would discuss a relatively new but promising future direction towards MEMS biomedical implants. Specifically, Parylene C has been explored to be used as a good MEMS implant material and will be discussed in detail. Demonstrated implant devices, such as retinal and spinal cord implants, are presented in this article.

  16. Amending soils with phosphate as means to mitigate soil lead hazard: a critical review of the state of the science.

    Science.gov (United States)

    Scheckel, Kirk G; Diamond, Gary L; Burgess, Michele F; Klotzbach, Julie M; Maddaloni, Mark; Miller, Bradley W; Partridge, Charles R; Serda, Sophia M

    2013-01-01

    Ingested soil and surface dust may be important contributors to elevated blood lead (Pb) levels in children exposed to Pb contaminated environments. Mitigation strategies have typically focused on excavation and removal of the contaminated soil. However, this is not always feasible for addressing widely disseminated contamination in populated areas often encountered in urban environments. The rationale for amending soils with phosphate is that phosphate will promote formation of highly insoluble Pb species (e.g., pyromorphite minerals) in soil, which will remain insoluble after ingestion and, therefore, inaccessible to absorption mechanisms in the gastrointestinal tract (GIT). Amending soil with phosphate might potentially be used in combination with other methods that reduce contact with or migration of contaminated soils, such as covering the soil with a green cap such as sod, clean soil with mulch, raised garden beds, or gravel. These remediation strategies may be less expensive and far less disruptive than excavation and removal of soil. This review evaluates evidence for efficacy of phosphate amendments for decreasing soil Pb bioavailability. Evidence is reviewed for (1) physical and chemical interactions of Pb and phosphate that would be expected to influence bioavailability, (2) effects of phosphate amendments on soil Pb bioaccessibility (i.e., predicted solubility of Pb in the GIT), and (3) results of bioavailability bioassays of amended soils conducted in humans and animal models. Practical implementation issues, such as criteria and methods for evaluating efficacy, and potential effects of phosphate on mobility and bioavailability of co-contaminants in soil are also discussed.

  17. Nanomaterials and nanofabrication for biomedical applications

    Science.gov (United States)

    Cheng, Chao-Min; Chia-Wen Wu, Kevin

    2013-08-01

    Traditional boundaries between materials science and engineering and life sciences are rapidly disintegrating as interdisciplinary research teams develop new materials-science-based tools for exploring fundamental issues in both medicine and biology. With recent technological advances in multiple research fields such as materials science, cell and molecular biology and micro-/nano-technology, much attention is shifting toward evaluating the functional advantages of nanomaterials and nanofabrication, at the cellular and molecular levels, for specific, biomedically relevant applications. The pursuit of this direction enhances the understanding of the mechanisms of, and therapeutic potentials for, some of the most lethal diseases, including cardiovascular diseases, organ fibrosis and cancers. This interdisciplinary approach has generated great interest among researchers working in a wide variety of communities including industry, universities and research laboratories. The purpose of this focus issue in Science and Technology of Advanced Materials is to bridge nanotechnology and biology with medicine, focusing more on the applications of nanomaterials and nanofabrication in biomedically relevant issues. This focus issue, we believe, will provide a more comprehensive understanding of (i) the preparation of nanomaterials and the underlying mechanisms of nanofabrication, and (ii) the linkage of nanomaterials and nanofabrication with biomedical applications. The multidisciplinary focus issue that we have attempted to organize is of interest to various research fields including biomaterials and tissue engineering, bioengineering, nanotechnology and nanomaterials, i.e. chemistry, physics and engineering. Nanomaterials and nanofabrication topics addressed in this focus issue include sensing and diagnosis (e.g. immunosensing and diagnostic devices for diseases), cellular and molecular biology (e.g. probing cellular behaviors and stem cell differentiation) and drug delivery

  18. Recent progress in biomedical applications of magnetic nanoparticles

    KAUST Repository

    Giouroudi, Ioanna

    2010-06-01

    Magnetic nanoparticles have been proposed for biomedical applications for several years. Various research groups worldwide have focused on improving their synthesis, their characterization techniques and the specific tailoring of their properties. Yet, it is the recent, impressive advances in nanotechnology and biotechnology which caused the breakthrough in their successful application in biomedicine. This paper aims at reviewing some current biomedical applications of magnetic nanoparticles as well as some recent patents in this field. Special emphasis is placed on i) hyperthermia, ii) therapeutics iii) diagnostics. Future prospects are also discussed. © 2010 Bentham Science Publishers Ltd.

  19. Biomedical education for clinical engineers.

    Science.gov (United States)

    Langevin, Francois; Donadey, Alain; Hadjes, Pierre; Blagosklonov, Oleg

    2007-01-01

    Biomedical equipment Master's degree is recognized by the French Ministry of Health, since its creation in 1975 under the denomination of "Specialization for Hospital Biomedical Engineers". Since the new national status of technical staff in the public service by decree of September 5th of 1991, it allows to access directly to the level of Chief Hospital Engineer (first category, second class, by ordinance of October 23rd, 1992). Biomedical Engineers jobs in French hospitals are selected after an examination organized by the recruiting hospital. Master's graduates are most often the best qualified.

  20. Engaging the community through an undergraduate biomedical physics course

    Science.gov (United States)

    Van Ness, G. R.; Widenhorn, Ralf

    2012-12-01

    We report on the development of an undergraduate biomedical physics course at Portland State University, motivated by both student interest and the desire of the university's Physics Department to provide an interdisciplinary intermediate-level physics course. The course was developed through the community engagement of physicians, clinical researchers, and basic science researchers. Class meetings were a combination of regular and guest lectures, hands-on exercises, web-based activities, class discussions, and a student poster information session for patrons at a local science museum. The course inspired students to engage in research projects in biomedical physics that enhance their understanding of science and education as well as benefit the learning of future students. Furthermore, this course offers an opportunity for traditionally underrepresented groups in physics courses, such as women, to gain additional exposure to physics.

  1. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    No 10, Oct 84) 36 NONIONIZING ELECTROMAGNETIC RADIATION EFFECTS Combined Effects of Heterogenous 2,4 GHz Microwave and Gamma-Irradiation on...632.8 nm, 25 mW) in this respect. Such pretreatment has been shown to stimulate germination and growth and, by diminishing losses due to fungal...ELECTROMAGNETIC RADIATION EFFECTS UDC 591.1 COMBINED EFFECTS OF HETEROGENOUS 2,4 GHz MICROWAVE AND GAMMA-IRRADIATION ON BLOOD-BRAIN BARRIER IN RAT Moscow

  2. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    1985-01-28

    south, in 15 years. It must be noted that there had also been accidental transportation of rats to this zone even before the virgin land started to be...interrelationship between cortical and autonomic processes in healthy subjects (18-33 years) and patients with cerebrovascular disease (42-56 years), to...toto, these observations indicate that the pattern of interaction responsible for regulating brain function is compromised in cerebrovascular

  3. USSR Report, Life Sciences, Biomedical and Behavioral Sciences, No. 39

    Science.gov (United States)

    2007-11-02

    deliberately asked in a " sick " voice: "May I please speak with Trifilov." "This is Trifilov." "Hello, Boris Ivanovich. You recognized me?" "Of course...patients and 10 persons with chronic tonsillitis, in reference to their agglutinability by the patient’s blood serum and their sensitivity to...antibiotics Clevomycetin, tetracyclin, streptomycin, erythromycin, penicillin , chlorotetracycline, monomycin) showed great non-uniformity in sensitivity

  4. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    brucellosis from sheep, goats , and pigs. In all the animals infected with a brucellosis agent, the highest titers of autoantibodies were against...infected with brucellosis agents from sheep, goats , and especially pigs, the titers of autoantibodies against antigens from the spleen and lymph nodes were...EPIDEMIOLOGII I IMMUNOBIOLOGII, No 11, 1983) 143 Autoantibody Formation in Brucellosis (N. I. Tikhenko, et al.; ZHURNAL MIKROBIOLOGII

  5. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    contribution. After all, from one plant cell one can obtain a mature plant—a fruit tree , berry bushes, potatoes, and many vegetables. Such production is...ground, cotton growing, intensive industrial horticulture, citrus growing, viticulture, tea growing, and so forth. The Kiev Institute of Labor Hygiene...an allergical nature: allergic rhinopathy, conjunctivitis, dermatitis, eczema , bronchial asthma, and chronic asthmatic bronchitis, which are

  6. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    1987-03-10

    arsenal of research techniques . Among those honored in this fashion is Valeriy Kazimirovich Lishko, director of the Institute of Biochemistry of the...cytogenetic stabilization, pollen fertility, aneuploidy and formation of productivity traits of plants in early generations (F..-F5) of new hexaploid...view of reports, some contested, that laser irradiation of crop seeds promotes germination and enhances yields, a statistical evaluation was conducted

  7. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    1984-12-05

    was observed in the experiments on mice and chicks. Pathological changes in the lungs were reduced, and dissemination of the virus In the body was...present article reports on molecular mechanisms of glucocorticoid hormones such as corticosterone, hydrocortisone and, to a lesser degree, cortisone , as

  8. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    system involvement: hepatorenal, cardiovascular, pulmonary, meningeal, abdominal and gastrointestinal . References 6: 3 Russian, 3 Western. [229...method for fecal and urine examination is best for detecting nematodes . In blood analysis for tropical diseases, thick drop and thin smears treated...Malyutka and Malysh-fed displayed more acute gastrointestinal infections. The kefir-fed babies suffered more frequent respiratory tract infections

  9. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    the way of the sonic wave is an acoustical lens, a very special part of the body, which exists only in cetaceans , the so-called melon (Figure 8...specialized children’s homes until they are 4 years old, and then are transferred to the home-boarding school system of social welfare . Thus, according

  10. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    most important groups of phytoparasitic nematodes was very important to the development of systematics ; it was organized in the 1970’s by the...plant protection. Consideration is given to useful organisms referable to different systematic groups: insects, viruses, fungi, protozoans, etc...used is a few grams per hectare, and it destroys many species of pests ( Lepidoptera , beetles, bugs, aphids, Coccidae). Fastak is virtually safe for

  11. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    Krylov, A. N. Petrov, et al.; FARMAKOLOGIYA I TOKSIKOLOGIYA, No 1, Jan-Feb 86) 51 Experimental Tests for Detection of Addictive Agents (N. K... carbohydrates characterized by low levels of metabolic activity. Equilibrium situation for 14C is attained in ca. 78 days in the case of bean leaves...EXPERIMENTAL TESTS FOR DETECTION OF ADDICTIVE AGENTS Moscow FARMAKOLOGIYA I TOKSIKOLOGIYA in Russian Vol 49, No 1, Jan-Feb 86 (manuscript received 7 Jun 84) pp

  12. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    Composition of Free Aminoacids in Blood of Hypokinetic Rats (T. F. Vlasova, M. S. Belakovskiy, et al.; VOPROSY PITANIYA, No 1, Jan-Feb 86...06:612.766.2 EFFECT OF DIETS WITH ACTIVE VITAMIN D3 METABOLITE AND VARYING CALCIUM AND PHOSPHORUS CONTENT ON COMPOSITION OF FREE AMINOACIDS IN...Miroshnikova, I. N. Sergeyev and V. B. Spirichev, Institute of Medical Biological Problems, USSR Ministry of Health, Moscow] [Abstract] Aminoacid metabolism

  13. USSR Report. Life Sciences: Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    schedule). Yields rise to 25 percent. Besides, seed treatment improves the biochemical properties of the plants. For example, the green mass of maize ...grown for silage has a higher fat and protein content, while cabbage contains more vitamin C. Sugar beets increase their sugar content, and sunflower

  14. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    1983-09-13

    conditions, the young females reached sexual maturity at the age of 50 days, on the average, but onset of the estral cycle varied for individuals...Cloning and Structure of Rat DNA Fragments Homologous to Murine Sarcoma Virus Mos Oncogene (0, V. Sayanova, et al.; DOKLADY AKADEMII NAÜK SSSR, Feb 83...32 LASER EFFECTS Effects of Low Intensity Laser Light on Aspartate Aminotransferase Activity in Rat Brain and Liver (V. M. Lavrova, et al,; VYESTSI

  15. USSR Report, Life Sciences, Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    1 Chair of Eye Diseases and Chair of Histology and Embryology , Rostov Medical Institute] [Abstract] Histological comparison was conducted on the...determination of alcohol, its storage, and other processes. This required a review of rules and regulations pertaining to the acquisition, processing...and presently represent about 12% of all pharmacies. One of their major functions is monitoring adherence to pharmaceutical rules and quality of

  16. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    SERIYA BIOLOGICHESKAYA, No 5, Sep-Oct 83) 11 Fucoid Algae as Bioindicators of Heavy Metal Contamination of Atlantic and Western Pacific Coastal Waters...Preparing Bioindicators for Monitoring Effectiveness of Sterilization Processes (N. M. Kalinina, et al.; ANTIBIOTIKI, No 8, Aug 83) 47 Microbial... BIOINDICATORS OF HEAVY METAL CONTAMINATION OF ATLANTIC AND WESTERN PACIFIC COASTAL WATERS Vladivostok BIOLOGIYA MORYA in Russian No 1, Jan-Feb 83

  17. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    EPIDEMIOLOGII I IMMUNOBIOLOGII, No 6, Jun 84) 40 Congenital and Hereditary Nephropathies Among Children According to Epidemiologie Investigation...Capabilities for Diagnosis of Hepatitis B (A. S. Novokhatskiy, V. M. Zhdanov; VOPROSY VIRUSOLOGII, No 2, Mar-Apr 84) 73 Formation of Specific...19° Influence of Therapy for Pregnancy -Associated Anemia on Status of Neonates and Children Under One Year of Age (T. P. Kollsnlchenko

  18. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    E, Nizkyy; RADIOBIOLOGIYA, No 4, Jul-Aug 83) ’ • • " 56 Radioprotectlve and Toxic Effects of ATP- AET -Serotonin Combination in Mice: Optimum...Krasnov), USSR Ministry of Health, Moscow iAbsrract] Preretinal macular fibrosis is a major cause of reduced visual acuity following surgical treatment...and the effectiveness of traditional methods of laser coagulation is compared with that of a new principle of laser surgery considering annew visual

  19. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    1985-02-05

    bonding the antigens to erythrocytes were determined.. The concentrations of chromium chloride and tannin to-be used for preliminary treatment of the...conducted on the utility and effective- ness of using chlorine derived from sea water by electrolysis for disinfection aboard fishing vessels. Chlorine...used for technical purposes, was readily disinfected with chlorine concentrations of 5 mg/ml and exposure times of 10 min, if the microbial flora did

  20. USSR Report, Life Sciences Biomedical and Behavioral Sciences

    Science.gov (United States)

    1984-02-15

    the blood-brain barrier and lipid synthesis. References 9: 1 Polish, 4 Russian, 4 Western. [130-12172] 34 UDC 616.61-78 POROUS STRUCTURE OF...Latrodectus tredecimguttatus spider venom possess- ing channel-forming properties on bilayer lipid membranes has been isolated and identified as a presynaptic...Pathologic-anatomic changes included hemorrhagic diathesis, liver dystrophy, myocardial atrophy, jaundice of subcutaneous tissue and serous linings and

  1. USSR Report, Life Sciences Biomedical and Behavioral Sciences.

    Science.gov (United States)

    2007-11-02

    et al.; VESTNIK KHIRURGII IMENI I.I. GREKOVA, No 10, Oct 86) 24 MICROBIOLOGY Adhesion of Aspergillus Niger Conidia to Polymeric Surfaces (I.V...579.083.131:621.0398 ADHESION OF ASPERGILLUS NIGER CONIDIA TO POLYMERIC SURFACES Moscow DOKLADY AKADEMII NAUK SSSR in Russian Vol 291, No 5, Dec 86...deterioration of polymeric materials, a study was conducted on the adhesion of Aspergillus niger conidia to polymeric surfaces. Strength of adhesion was

  2. USSR Report, Life Sciences, Biomedical and Behavioral Sciences, No. 38.

    Science.gov (United States)

    1983-07-22

    membrane protein". Using sodium dodecylsulfate with electro- phoresis in a polyacrylamide gel, Lugtenberg and coauthors [10] discovered that this...outer membrane proteins was done in a 10 percent polyacrylamide gel with 2 percent sodium dodecylsulfate [10], The electrophoresis was done in glass...the food ration of individual population groups, a predominance of starch and groats dishes and in some cases an insufficient consumption of animal

  3. USSR Report. Life Sciences: Biomedical and Behavioral Sciences

    Science.gov (United States)

    2007-11-02

    abscisic acid led to enhanced accumulation of plant levels of mono- and disaccharides, water-soluble polysaccharides, starch , hemicellulose, and...transferring the nuclear proteins from polyacrylamide gel to a nitrocellulose filter and incubation with a 125I-labeled regulatory subunit. The subunit can...purification are homogeneous according to electrophoresis in polyacrylamide gel in the presence of sodium dodecyl sulfate. Figures 3; references 10: 2

  4. USSR Report: Life Sciences, Biomedical and Behavioral Sciences, No. 40

    Science.gov (United States)

    1983-09-02

    formed a dilatation of its caudal end in the form of wings . Concurrently, there was proliferation in width of its anterior end. These age-related...and presphenoid are formed from three ossification centers. The ossification centers merge into the anterior and central sphenoid in Stenella when the...supraoccipital membrane bone and surrounded, in the form of wide wings , virtually the entire supraoccipital bone on the sides and at the top (Romer

  5. USSR Report, Life Sciences, Biomedical and Behavioral Sciences

    Science.gov (United States)

    1987-01-20

    of the gram-positive bacteria Bacillus oligonitrophilus in rocking flasks. The method of "dialysis" of cultures was used, allowing a comparison to...male white mice and rats. The anticonvulsive effect of the compounds was studied by their antagonism to the convulsive effect of corazol

  6. Functionalized carbon nanotubes: biomedical applications.

    Science.gov (United States)

    Vardharajula, Sandhya; Ali, Sk Z; Tiwari, Pooja M; Eroğlu, Erdal; Vig, Komal; Dennis, Vida A; Singh, Shree R

    2012-01-01

    Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.

  7. New Directions for Biomedical Engineering

    Science.gov (United States)

    Plonsey, Robert

    1973-01-01

    Discusses the definition of "biomedical engineering" and the development of educational programs in the field. Includes detailed descriptions of the roles of bioengineers, medical engineers, and chemical engineers. (CC)

  8. Program of “Okayama Biomedical Engineering Professional” for Local Renovation

    Science.gov (United States)

    Hayashi, Kozaburo

    Okayama University of Science, Department of Biomedical Engineering, is promoting a program of “Okayama Biomedical Engineering Professional” for the development and renovation of biomedical industries in Okayama area. This is one of the programs of the national project on “Formation of the Center for the Production of Capable Persons for Local Renovation” , sponsored by the Ministry of Education, Culture, Sports, Science and Technology, Japan, and performed by the Japan Science and Technology Agency. The purpose of the program is to develop and educate specialists for the research, development, production, and marketing of biomedical devices and equipment in local industries in Okayama area. A half a year training for approximately 5 students from industries consists of 12 days of lectures and experiments, which is repeatedly provided for 5 years (approximately 45 students in total) .

  9. Biomedical engineer: an international job.

    Science.gov (United States)

    Crolet, Jean-Marie

    2007-01-01

    Biomedical engineer is an international job for several reasons and it means that the knowledge of at least one foreign language is a necessity. A geographical and structural analysis of the biomedical sector concludes to the teaching of a second foreign language. But in spite of the presence of adequate means, it is not possible for us for the moment to set up such a teaching. This paper presents the solution we have chosen in the framework of Erasmus exchanges.

  10. Hydroxyapatite coatings for biomedical applications

    CERN Document Server

    Zhang, Sam

    2013-01-01

    Hydroxyapatite coatings are of great importance in the biological and biomedical coatings fields, especially in the current era of nanotechnology and bioapplications. With a bonelike structure that promotes osseointegration, hydroxyapatite coating can be applied to otherwise bioinactive implants to make their surface bioactive, thus achieving faster healing and recovery. In addition to applications in orthopedic and dental implants, this coating can also be used in drug delivery. Hydroxyapatite Coatings for Biomedical Applications explores developments in the processing and property characteri

  11. John Glenn Biomedical Engineering Consortium

    Science.gov (United States)

    Nall, Marsha

    2004-01-01

    The John Glenn Biomedical Engineering Consortium is an inter-institutional research and technology development, beginning with ten projects in FY02 that are aimed at applying GRC expertise in fluid physics and sensor development with local biomedical expertise to mitigate the risks of space flight on the health, safety, and performance of astronauts. It is anticipated that several new technologies will be developed that are applicable to both medical needs in space and on earth.

  12. Biomedical ontologies: a functional perspective.

    Science.gov (United States)

    Rubin, Daniel L; Shah, Nigam H; Noy, Natalya F

    2008-01-01

    The information explosion in biology makes it difficult for researchers to stay abreast of current biomedical knowledge and to make sense of the massive amounts of online information. Ontologies--specifications of the entities, their attributes and relationships among the entities in a domain of discourse--are increasingly enabling biomedical researchers to accomplish these tasks. In fact, bio-ontologies are beginning to proliferate in step with accruing biological data. The myriad of ontologies being created enables researchers not only to solve some of the problems in handling the data explosion but also introduces new challenges. One of the key difficulties in realizing the full potential of ontologies in biomedical research is the isolation of various communities involved: some workers spend their career developing ontologies and ontology-related tools, while few researchers (biologists and physicians) know how ontologies can accelerate their research. The objective of this review is to give an overview of biomedical ontology in practical terms by providing a functional perspective--describing how bio-ontologies can and are being used. As biomedical scientists begin to recognize the many different ways ontologies enable biomedical research, they will drive the emergence of new computer applications that will help them exploit the wealth of research data now at their fingertips.

  13. RPCs in biomedical applications

    Science.gov (United States)

    Belli, G.; De Vecchi, C.; Giroletti, E.; Guida, R.; Musitelli, G.; Nardò, R.; Necchi, M. M.; Pagano, D.; Ratti, S. P.; Sani, G.; Vicini, A.; Vitulo, P.; Viviani, C.

    2006-08-01

    We are studying possible applications of Resistive Plate Chambers (RPCs) in the biomedical domain such as Positron Emission Tomography (PET). The use of RPCs in PET can provide several improvements on the usual scintillation-based detectors. The most striking features are the extremely good spatial and time resolutions. They can be as low as 50 μm and 25 ps respectively, to be compared to the much higher intrinsic limits in bulk detectors. Much efforts have been made to investigate suitable materials to make RPCs sensitive to 511 keV photons. For this reason, we are studying different types of coating employing high Z materials with proper electrical resistivity. Later investigations explored the possibility of coating glass electrodes by mean of serigraphy techniques, employing oxide based mixtures with a high density of high Z materials; the efficiency is strongly dependent on its thickness and it reaches a maximum for a characteristic value that is a function of the compound (usually a few hundred microns). The most promising mixtures seem to be PbO, Bi 2O 3 and Tl 2O. Preliminary gamma efficiency measurements for a Multigap RPC prototype (MRPC) are presented as well as simulations using GEANT4-based framework. The MRPC has 5 gas gaps; their spacings are kept by 0.3 mm diameter nylon fishing line, electrodes are made of thin glasses (1 mm for the outer electrodes, 0.15-0.4 mm for the inner ones). The detector is enclosed in a metallic gas-tight box, filled with a C 2H 2F 4 92.5%, SF 6 2.5%, C 4H 10 5% mixture. Different gas mixtures are being studied increasing the SF6 percentage and results of efficiency as a function of the new mixtures will be presented.

  14. RPCs in biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Belli, G. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); De Vecchi, C. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Giroletti, E. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Guida, R. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Musitelli, G. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Nardo, R. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Necchi, M.M. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Pagano, D. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Ratti, S.P. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Sani, G. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Vicini, A. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Vitulo, P. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy); Viviani, C. [Dipartimento di Fisica Nucleare e Teorica and Sezione INFN, via A. Bassi 6, 27100 Pavia (Italy)

    2006-08-15

    We are studying possible applications of Resistive Plate Chambers (RPCs) in the biomedical domain such as Positron Emission Tomography (PET). The use of RPCs in PET can provide several improvements on the usual scintillation-based detectors. The most striking features are the extremely good spatial and time resolutions. They can be as low as 50 {mu}m and 25 ps respectively, to be compared to the much higher intrinsic limits in bulk detectors. Much efforts have been made to investigate suitable materials to make RPCs sensitive to 511 keV photons. For this reason, we are studying different types of coating employing high Z materials with proper electrical resistivity. Later investigations explored the possibility of coating glass electrodes by mean of serigraphy techniques, employing oxide based mixtures with a high density of high Z materials; the efficiency is strongly dependent on its thickness and it reaches a maximum for a characteristic value that is a function of the compound (usually a few hundred microns). The most promising mixtures seem to be PbO, Bi{sub 2}O{sub 3} and Tl{sub 2}O. Preliminary gamma efficiency measurements for a Multigap RPC prototype (MRPC) are presented as well as simulations using GEANT4-based framework. The MRPC has 5 gas gaps; their spacings are kept by 0.3 mm diameter nylon fishing line, electrodes are made of thin glasses (1 mm for the outer electrodes, 0.15-0.4 mm for the inner ones). The detector is enclosed in a metallic gas-tight box, filled with a C{sub 2}H{sub 2}F{sub 4} 92.5%, SF{sub 6} 2.5%, C{sub 4}H{sub 10} 5% mixture. Different gas mixtures are being studied increasing the SF6 percentage and results of efficiency as a function of the new mixtures will be presented.

  15. Physical sciences and engineering advances in life sciences and oncology a WTEC global assessment

    CERN Document Server

    Fletcher, Daniel; Gerecht, Sharon; Levine, Ross; Mallick, Parag; McCarty, Owen; Munn, Lance; Reinhart-King, Cynthia

    2016-01-01

    This book presents an Assessment of Physical Sciences and Engineering Advances in Life Sciences and Oncology (APHELION) by a panel of experts. It covers the status and trends of applying physical sciences and engineering principles to oncology research in leading laboratories and organizations in Europe and Asia. The book elaborates on the six topics identified by the panel that have the greatest potential to advance understanding and treatment of cancer, each covered by a chapter in the book. The study was sponsored by the National Cancer Institute (NCI) at the National Institute of Health (NIH), the National Science Foundation (NSF) and the National Institute of Biomedical Imaging and Bioengineering at the NIH in the US under a cooperative agreement with the World Technology Evaluation Center (WTEC).

  16. Biomedical journals in Republic of Macedonia: the current state.

    Science.gov (United States)

    Polenakovic, Momir; Danevska, Lenche

    2014-01-01

    Several biomedical journals in the Republic of Macedonia have succeeded in maintaining regular publication over the years, but only a few have a long-standing tradition. In this paper we present the basic characteristics of 18 biomedical journals that have been published without a break in the Republic of Macedonia. Of these, more details are given for 14 journals, a particular emphasis being on the journal Prilozi/Contributions of the Macedonian Academy of Sciences and Arts, Section of Medical Sciences as one of the journals with a long-term publishing tradition and one of the journals included in the Medline/PubMed database. A brief or broad description is given for the following journals: Macedonian Medical Review, Acta Morphologica, Physioacta, MJMS-Macedonian Journal of Medical Sciences, International Medical Journal Medicus, Archives of Public Health, Epilepsy, Macedonian Orthopaedics and Traumatology Journal, BANTAO Journal, Macedonian Dental Review, Macedonian Pharmaceutical Bulletin, Macedonian Veterinary Review, Journal of Special Education and Rehabilitation, Balkan Journal of Medical Genetics, Contributions of the Macedonian Scientific Society of Bitola, Vox Medici, Social Medicine: Professional Journal for Public Health, and Prilozi/Contributions of the Macedonian Academy of Sciences and Arts. Journals from Macedonia should aim to be published regularly, should comply with the Uniform requirements for manuscripts submitted to biomedical journals, and with the recommendations of reliable organizations working in the field of publishing and research. These are the key prerequisites which Macedonian journals have to accomplish in order to be included in renowned international bibliographic databases. Thus the results of biomedical science from the Republic of Macedonia will be presented to the international scientific arena.

  17. Multi-scale biomedical systems: measurement challenges

    Science.gov (United States)

    Summers, R.

    2016-11-01

    Multi-scale biomedical systems are those that represent interactions in materials, sensors, and systems from a holistic perspective. It is possible to view such multi-scale activity using measurement of spatial scale or time scale, though in this paper only the former is considered. The biomedical application paradigm comprises interactions that range from quantum biological phenomena at scales of 10-12 for one individual to epidemiological studies of disease spread in populations that in a pandemic lead to measurement at a scale of 10+7. It is clear that there are measurement challenges at either end of this spatial scale, but those challenges that relate to the use of new technologies that deal with big data and health service delivery at the point of care are also considered. The measurement challenges lead to the use, in many cases, of model-based measurement and the adoption of virtual engineering. It is these measurement challenges that will be uncovered in this paper.

  18. From biomedical-engineering research to clinical application and industrialization

    Science.gov (United States)

    Taguchi, Tetsushi; Aoyagi, Takao

    2012-12-01

    The rising costs and aging of the population due to a low birth rate negatively affect the healthcare system in Japan. In 2011, the Council for Science and Technology Policy released the 4th Japan's Science and Technology Basic Policy Report from 2011 to 2015. This report includes two major innovations, 'Life Innovation' and 'Green Innovation', to promote economic growth. Biomedical engineering research is part of 'Life Innovation' and its outcomes are required to maintain people's mental and physical health. It has already resulted in numerous biomedical products, and new ones should be developed using nanotechnology-based concepts. The combination of accumulated knowledge and experience, and 'nanoarchitechtonics' will result in novel, well-designed functional biomaterials. This focus issue contains three reviews and 19 original papers on various biomedical topics, including biomaterials, drug-delivery systems, tissue engineering and diagnostics. We hope that it demonstrates the importance of collaboration among scientists, engineers and clinicians, and will contribute to the further development of biomedical engineering.

  19. The biomedical engineer as a driver for Health Technology innovation.

    Science.gov (United States)

    Colas Fustero, Javier; Guillen Arredondo, Alejandra

    2010-01-01

    Health Technology has played a mayor role on most of the fundamental advances in medicine, in the last 30 years. Right now, beginning the XXI Century, it is well accepted that the most important revolution expected in Health Care is the empowerment of the individuals on their own health management. Innovation in health care technologies will continue being paramount, not only in the advances of medicine and in the self health management of patients but also in allowing the sustainability of the public health care becomes more important, the role of the biomedical engineer will turn to be more crucial for the society. The paper targets the development of new curricula for the Biomedical Engineers, The needs of evolving on his different fields in which the contribution of the Biomedical Engineer is becoming fundamental to drive the innovation that Health Care Technology Industry must provide to continue improving human health through cross-disciplinary activities that integrate the engineering sciences with the biomedical sciences and clinical practice.

  20. Adaptive optics applications in vision science

    Science.gov (United States)

    Olivier, Scot S.

    2003-06-01

    Adaptive optics can be used to correct the aberrations in the human eye caused by imperfections in the cornea and the lens and thereby, improve image quality both looking into and out of the eye. Under the auspices of the NSF Center for Adaptive Optics and the DOE Biomedical Engineering Program, Lawrence Livermore National Laboratory has joined together with leading vision science researchers around the country to develop and test new ophthalmic imaging systems using novel wavefront corrector technologies. Results of preliminary comparative evaluations of these technologies in initial system tests show promise for future clinical utility.

  1. The biomedical discourse relation bank

    Directory of Open Access Journals (Sweden)

    Joshi Aravind

    2011-05-01

    Full Text Available Abstract Background Identification of discourse relations, such as causal and contrastive relations, between situations mentioned in text is an important task for biomedical text-mining. A biomedical text corpus annotated with discourse relations would be very useful for developing and evaluating methods for biomedical discourse processing. However, little effort has been made to develop such an annotated resource. Results We have developed the Biomedical Discourse Relation Bank (BioDRB, in which we have annotated explicit and implicit discourse relations in 24 open-access full-text biomedical articles from the GENIA corpus. Guidelines for the annotation were adapted from the Penn Discourse TreeBank (PDTB, which has discourse relations annotated over open-domain news articles. We introduced new conventions and modifications to the sense classification. We report reliable inter-annotator agreement of over 80% for all sub-tasks. Experiments for identifying the sense of explicit discourse connectives show the connective itself as a highly reliable indicator for coarse sense classification (accuracy 90.9% and F1 score 0.89. These results are comparable to results obtained with the same classifier on the PDTB data. With more refined sense classification, there is degradation in performance (accuracy 69.2% and F1 score 0.28, mainly due to sparsity in the data. The size of the corpus was found to be sufficient for identifying the sense of explicit connectives, with classifier performance stabilizing at about 1900 training instances. Finally, the classifier performs poorly when trained on PDTB and tested on BioDRB (accuracy 54.5% and F1 score 0.57. Conclusion Our work shows that discourse relations can be reliably annotated in biomedical text. Coarse sense disambiguation of explicit connectives can be done with high reliability by using just the connective as a feature, but more refined sense classification requires either richer features or more

  2. Rotation Covariant Image Processing for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Henrik Skibbe

    2013-01-01

    Full Text Available With the advent of novel biomedical 3D image acquisition techniques, the efficient and reliable analysis of volumetric images has become more and more important. The amount of data is enormous and demands an automated processing. The applications are manifold, ranging from image enhancement, image reconstruction, and image description to object/feature detection and high-level contextual feature extraction. In most scenarios, it is expected that geometric transformations alter the output in a mathematically well-defined manner. In this paper we emphasis on 3D translations and rotations. Many algorithms rely on intensity or low-order tensorial-like descriptions to fulfill this demand. This paper proposes a general mathematical framework based on mathematical concepts and theories transferred from mathematical physics and harmonic analysis into the domain of image analysis and pattern recognition. Based on two basic operations, spherical tensor differentiation and spherical tensor multiplication, we show how to design a variety of 3D image processing methods in an efficient way. The framework has already been applied to several biomedical applications ranging from feature and object detection tasks to image enhancement and image restoration techniques. In this paper, the proposed methods are applied on a variety of different 3D data modalities stemming from medical and biological sciences.

  3. Biomedical journals: keeping up and reading critically.

    Science.gov (United States)

    Chase, Karen L; DiGiacomo, Ronald F; Van Hoosier, Gerald L

    2006-09-01

    By extrapolation from studies of physicians, knowledge and practice of laboratory animal medicine and science are expected to become progressively more outdated the longer practitioners are out of school. Keeping up with current literature and practice is a challenge that necessitates the use of many different sources of continuing education. Both veterinarians and physicians consistently list journals as the most beneficial source of new information. Accordingly, they must select from the veterinary and biomedical literature articles that report original studies and systematic reviews and recognize and respond to valid new knowledge to improve diagnostic and therapeutic approaches and maintain consistent clinical skills. Other objectives include selecting journals for general information and for information relevant or specific to one's field of research. Lastly, candidates for board certification need to read articles from journals that potentially provide the basis for questions on the examination. 'High-impact' journals should be identified, and articles should be reviewed critically. In a survey of recent candidates for laboratory animal medicine board examination, these journals included Contemporary Topics (now JAALAS), Comparative Medicine, ILAR Journal, and Laboratory Animals. Strategies for coping with the challenge of staying current with the literature include wise use of technology, journal clubs, and consultation with colleagues. A laboratory animal practitioner can become a better scientist and clinician by evaluating the research performed by others. Thorough, critical review of biomedical literature is paramount to these goals.

  4. Recent Advances in Shape Memory Soft Materials for Biomedical Applications.

    Science.gov (United States)

    Chan, Benjamin Qi Yu; Low, Zhi Wei Kenny; Heng, Sylvester Jun Wen; Chan, Siew Yin; Owh, Cally; Loh, Xian Jun

    2016-04-27

    Shape memory polymers (SMPs) are smart and adaptive materials able to recover their shape through an external stimulus. This functionality, combined with the good biocompatibility of polymers, has garnered much interest for biomedical applications. In this review, we discuss the design considerations critical to the successful integration of SMPs for use in vivo. We also highlight recent work on three classes of SMPs: shape memory polymers and blends, shape memory polymer composites, and shape memory hydrogels. These developments open the possibility of incorporating SMPs into device design, which can lead to vast technological improvements in the biomedical field.

  5. Biomaterials surface science

    CERN Document Server

    Taubert, Andreas; Rodriguez-Cabello, José Carlos

    2013-01-01

    The book provides an overview of the highly interdisciplinary field of surface science in the context of biological and biomedical applications. The covered topics range from micro- and nanostructuring for imparting functionality in a top-down manner to the bottom-up fabrication of gradient surfaces by self-assembly, from interfaces between biomaterials and living matter to smart, stimuli-responsive surfaces, and from cell and surface mechanics to the elucidation of cell-chip interactions in biomedical devices.

  6. [Master course in biomedical engineering].

    Science.gov (United States)

    Jobbágy, Akos; Benyó, Zoltán; Monos, Emil

    2009-11-22

    The Bologna Declaration aims at harmonizing the European higher education structure. In accordance with the Declaration, biomedical engineering will be offered as a master (MSc) course also in Hungary, from year 2009. Since 1995 biomedical engineering course has been held in cooperation of three universities: Semmelweis University, Budapest Veterinary University, and Budapest University of Technology and Economics. One of the latter's faculties, Faculty of Electrical Engineering and Informatics, has been responsible for the course. Students could start their biomedical engineering studies - usually in parallel with their first degree course - after they collected at least 180 ECTS credits. Consequently, the biomedical engineering course could have been considered as a master course even before the Bologna Declaration. Students had to collect 130 ECTS credits during the six-semester course. This is equivalent to four-semester full-time studies, because during the first three semesters the curriculum required to gain only one third of the usual ECTS credits. The paper gives a survey on the new biomedical engineering master course, briefly summing up also the subjects in the curriculum.

  7. Nanomaterials in biomedical applications

    DEFF Research Database (Denmark)

    Christiansen, Jesper de Claville; Potarniche, Catalina-Gabriela; Vuluga, Z.

    2011-01-01

    Advances in nano materials have lead to applications in many areas from automotive to electronics and medicine. Nano composites are a popular group of nano materials. Nanocomposites in medical applications provide novel solutions to common problems. Materials for implants, biosensors and drug del...

  8. An Examination of Biomedical Intellectual Reputation in Relationship to Graduates' Productivity, Regional Innovation and Absorptive Capacity at Selected Universities Worldwide

    Science.gov (United States)

    Cavanaugh, Gesulla

    2014-01-01

    The purpose of this study was first to determine factors associated with intellectual reputation, specifically among selected biomedical departments worldwide within the university setting. Second, the study aimed to examine intellectual reputation in relationship to doctoral graduates' productivity in the biomedical sciences and in relationship…

  9. News CERN Celebration: CERN marks 20 years of the Web Workshops: Physics Teachers' Day aired live on Web Teacher Programme: Physics Teachers at CERN 2009 leaves attendees thirsty for more GIREP: Registration open for GIREP '09 Science and Creationism: Telegraph headline leads readers down wrong path Recruitment: Is recession proving to be good news for science teaching? Forthcoming Events

    Science.gov (United States)

    2009-05-01

    CERN Celebration: CERN marks 20 years of the Web Workshops: Physics Teachers' Day aired live on Web Teacher Programme: Physics Teachers at CERN 2009 leaves attendees thirsty for more GIREP: Registration open for GIREP '09 Science and Creationism: Telegraph headline leads readers down wrong path Recruitment: Is recession proving to be good news for science teaching? Forthcoming Events

  10. Pathophysiologic mechanisms of biomedical nanomaterials.

    Science.gov (United States)

    Wang, Liming; Chen, Chunying

    2016-05-15

    Nanomaterials (NMs) have been widespread used in biomedical fields, daily consuming, and even food industry. It is crucial to understand the safety and biomedical efficacy of NMs. In this review, we summarized the recent progress about the physiological and pathological effects of NMs from several levels: protein-nano interface, NM-subcellular structures, and cell-cell interaction. We focused on the detailed information of nano-bio interaction, especially about protein adsorption, intracellular trafficking, biological barriers, and signaling pathways as well as the associated mechanism mediated by nanomaterials. We also introduced related analytical methods that are meaningful and helpful for biomedical effect studies in the future. We believe that knowledge about pathophysiologic effects of NMs is not only significant for rational design of medical NMs but also helps predict their safety and further improve their applications in the future.

  11. Career development in Bioengineering/Biomedical Engineering: a student's roadmap.

    Science.gov (United States)

    Abu-Faraj, Ziad O

    2008-01-01

    Bioengineering/biomedical engineering education has progressed since the late 1950s and is still evolving in leading academic institutions worldwide. Today, Bioengineering/Biomedical Engineering is acclaimed as one of the most reputable fields within the global arena, and will likely be the catalyst for any future breakthroughs in Medicine and Biology. This paper provides a set of strategies and recommendations to be pursued by individuals aiming at planning and developing careers in this field. The paper targets the international student contemplating bioengineering/biomedical engineering as a career, with an underlying emphasis on the student within developing and transitional countries where career guidance is found deficient. The paper also provides a comprehensive definition of the field and an enumeration of its subdivisions.

  12. Leveraging Industry-Academia Collaborations in Adaptive Biomedical Innovation.

    Science.gov (United States)

    Stewart, S R; Barone, P W; Bellisario, A; Cooney, C L; Sharp, P A; Sinskey, A J; Natesan, S; Springs, S L

    2016-12-01

    Despite the rapid pace of biomedical innovation, research and development (R&D) productivity in the pharmaceutical industry has not improved broadly. Increasingly, firms need to leverage new approaches to product development and commercial execution, while maintaining adaptability to rapid changes in the marketplace and in biomedical science. Firms are also seeking ways to capture some of the talent, infrastructure, and innovation that depends on federal R&D investment. As a result, a major transition to external innovation is taking place across the industry. One example of these external innovation initiatives is the Sanofi-MIT Partnership, which provided seed funding to MIT investigators to develop novel solutions and approaches in areas of interest to Sanofi. These projects were highly collaborative, with information and materials flowing both ways. The relatively small amount of funding and short time frame of the awards built an adaptable and flexible process to advance translational science.

  13. Promising iron oxide-based magnetic nanoparticles in biomedical engineering.

    Science.gov (United States)

    Tran, Phuong Ha-Lien; Tran, Thao Truong-Dinh; Vo, Toi Van; Lee, Beom-Jin

    2012-12-01

    For the past few decades biomedical engineering has imprinted its significant impact on the map of science through its wide applications on many other fields. An important example obviously proving this fact is the versatile application of magnetic nanoparticles in theranostics. Due to preferable properties such as biocompatibility, non-toxicity compared to other metal derivations, iron oxide-based magnetic nanoparticles was chosen to be addressed in this review. Aim of this review is to give the readers a whole working window of these magnetic nanoparticles in the current context of science. Thus, preparation of magnetic iron oxide nanoparticles with the so-far techniques, methods of characterizing the nanoparticles as well as their most recent biomedical applications will be stated.

  14. Fluid-structure interaction and biomedical applications

    CERN Document Server

    Galdi, Giovanni; Nečasová, Šárka

    2014-01-01

    This book presents, in a methodical way, updated and comprehensive descriptions and analyses of some of the most relevant problems in the context of fluid-structure interaction (FSI). Generally speaking, FSI is among the most popular and intriguing problems in applied sciences and includes industrial as well as biological applications. Various fundamental aspects of FSI are addressed from different perspectives, with a focus on biomedical applications. More specifically, the book presents a mathematical analysis of basic questions like the well-posedness of the relevant initial and boundary value problems, as well as the modeling and the numerical simulation of a number of fundamental phenomena related to human biology. These latter research topics include blood flow in arteries and veins, blood coagulation and speech modeling. We believe that the variety of the topics discussed, along with the different approaches used to address and solve the corresponding problems, will help readers to develop a more holis...

  15. Implantable biomedical devices on bioresorbable substrates

    Science.gov (United States)

    Rogers, John A; Kim, Dae-Hyeong; Omenetto, Fiorenzo; Kaplan, David L; Litt, Brian; Viventi, Jonathan; Huang, Yonggang; Amsden, Jason

    2014-03-04

    Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.

  16. 病毒样颗粒技术——现代生物医学应用的新平台%Virus-like particles: new platforms for the applications of contemporary biomedical sciences

    Institute of Scientific and Technical Information of China (English)

    龙遗芳; 郭中敏; 陆家海

    2013-01-01

    Virus-like particles (VLPs) are composed of one or several virus structural proteins but not packaged the virus genome inside the capsid.VLPs have remarkable advantages over the complete viruses such as VLP can closely mimick the three-dimensional nature of a real virus; VLPs are safe with strong immunogenicity,flexibility of structure and unique ability of bearing DNA and other molecules.VLP technology has been widely accepted especially in the field of vaccinology.In this review,we summarize the applications of VLPs in the field of biomedical research including basic research,development of immunoassays,novel vaccines and VLPs as vehicles for delivering therapeutic molecules.

  17. Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health

    Science.gov (United States)

    Tromberg, Bruce J.; Anderson, R. Rox; Birngruber, Reginald; Brinkmann, Ralf; Berns, Michael W.; Parrish, John A.; Apiou-Sbirlea, Gabriela

    2016-12-01

    Despite widespread government and public interest, there are significant barriers to translating basic science discoveries into clinical practice. Biophotonics and biomedical optics technologies can be used to overcome many of these hurdles, due, in part, to offering new portable, bedside, and accessible devices. The current JBO special issue highlights promising activities and examples of translational biophotonics from leading laboratories around the world. We identify common essential features of successful clinical translation by examining the origins and activities of three major international academic affiliated centers with beginnings traceable to the mid-late 1970s: The Wellman Center for Photomedicine (Mass General Hospital, USA), the Beckman Laser Institute and Medical Clinic (University of California, Irvine, USA), and the Medical Laser Center Lübeck at the University of Lübeck, Germany. Major factors driving the success of these programs include visionary founders and leadership, multidisciplinary research and training activities in light-based therapies and diagnostics, diverse funding portfolios, and a thriving entrepreneurial culture that tolerates risk. We provide a brief review of how these three programs emerged and highlight critical phases and lessons learned. Based on these observations, we identify pathways for encouraging the growth and formation of similar programs in order to more rapidly and effectively expand the impact of biophotonics and biomedical optics on human health.

  18. Network fingerprint: a knowledge-based characterization of biomedical networks

    Science.gov (United States)

    Cui, Xiuliang; He, Haochen; He, Fuchu; Wang, Shengqi; Li, Fei; Bo, Xiaochen

    2015-01-01

    It can be difficult for biomedical researchers to understand complex molecular networks due to their unfamiliarity with the mathematical concepts employed. To represent molecular networks with clear meanings and familiar forms for biomedical researchers, we introduce a knowledge-based computational framework to decipher biomedical networks by making systematic comparisons to well-studied “basic networks”. A biomedical network is characterized as a spectrum-like vector called “network fingerprint”, which contains similarities to basic networks. This knowledge-based multidimensional characterization provides a more intuitive way to decipher molecular networks, especially for large-scale network comparisons and clustering analyses. As an example, we extracted network fingerprints of 44 disease networks in the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. The comparisons among the network fingerprints of disease networks revealed informative disease-disease and disease-signaling pathway associations, illustrating that the network fingerprinting framework will lead to new approaches for better understanding of biomedical networks. PMID:26307246

  19. Development of new metallic alloys for biomedical applications.

    Science.gov (United States)

    Niinomi, Mitsuo; Nakai, Masaaki; Hieda, Junko

    2012-11-01

    New low modulus β-type titanium alloys for biomedical applications are still currently being developed. Strong and enduring β-type titanium alloy with a low Young's modulus are being investigated. A low modulus has been proved to be effective in inhibiting bone atrophy, leading to good bone remodeling in a bone fracture model in the rabbit tibia. Very recently β-type titanium alloys with a self-tunable modulus have been proposed for the construction of removable implants. Nickel-free low modulus β-type titanium alloys showing shape memory and super elastic behavior are also currently being developed. Nickel-free stainless steel and cobalt-chromium alloys for biomedical applications are receiving attention as well. Newly developed zirconium-based alloys for biomedical applications are proving very interesting. Magnesium-based or iron-based biodegradable biomaterials are under development. Further, tantalum, and niobium and its alloys are being investigated for biomedical applications. The development of new metallic alloys for biomedical applications is described in this paper.

  20. Biomedical Imaging Principles and Applications

    CERN Document Server

    Salzer, Reiner

    2012-01-01

    This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may me

  1. Research and technology activities at Ames Research Center's Biomedical Research Division

    Science.gov (United States)

    Martello, N.

    1985-01-01

    Various research and technology activities at Ames Research Center's Biomedical Research Division are described. Contributions to the Space Administration's goals in the life sciences include descriptions of research in operational medicine, cardiovascular deconditioning, motion sickness, bone alterations, muscle atrophy, fluid and electrolyte changes, radiation effects and protection, behavior and performance, gravitational biology, and life sciences flight experiments.

  2. Epistemic modesty, ostentatiousness and the uncertainties of epigenetics: on the knowledge machinery of (social) science

    OpenAIRE

    Pickersgill, Martyn

    2016-01-01

    Abstract Epigenetic processes are garnering attention in the social sciences, where some scholars assert their importance for theorizing social life. I engage with such ideas here by drawing on interviews with leading bioscientists. To begin with, I underscore the (productive) uncertainties of those working in and around epigenetics; I describe these as a manifestation of ‘epistemic modesty’, and suggest that dissensus helps to propel biomedical innovation. Then, drawing on the concept of ‘al...

  3. Inorganic nanolayers: structure, preparation, and biomedical applications

    Directory of Open Access Journals (Sweden)

    Saifullah B

    2015-09-01

    Full Text Available Bullo Saifullah, Mohd Zobir B HusseinMaterials Synthesis and Characterization Laboratory, Institute of Advanced Technology (ITMA, Universiti Putra Malaysia, Serdang, MalaysiaAbstract: Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes, high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.Keywords: inorganic nanolayers, layered double hydroxides, layered hydroxy salts, drug delivery, biosensors, bioimaging

  4. National Institute of Biomedical Imaging and Bioengineering

    Science.gov (United States)

    ... Health & Human Services National Institutes of Health Creating Biomedical Technologies to Improve Health En Español | Site Map | ... 2016 VIEW MORE NEWS AND HIGHLIGHTS Design by Biomedical Undergraduate Teams Challenge RSS LISTSERV YOUTUBE FACEBOOK TWITTER ...

  5. Mathematical modeling in biomedical imaging

    CERN Document Server

    2009-01-01

    This volume gives an introduction to a fascinating research area to applied mathematicians. It is devoted to providing the exposition of promising analytical and numerical techniques for solving challenging biomedical imaging problems, which trigger the investigation of interesting issues in various branches of mathematics.

  6. Mathematical modeling in biomedical imaging

    CERN Document Server

    2012-01-01

    This volume reports on recent mathematical and computational advances in optical, ultrasound, and opto-acoustic tomographies. It outlines the state-of-the-art and future directions in these fields and provides readers with the most recently developed mathematical and computational tools.  It is particularly suitable for researchers and graduate students in applied mathematics and biomedical engineering.

  7. Biomedical applications of magnesium alloys

    NARCIS (Netherlands)

    Sillekens, W.H.; Bormann, D.

    2012-01-01

    This chapter deals with the emerging field of biomedical applications for magnesium-based materials, envisioning degradable implants that dissolve in the human body after having cured a particular medical condition. After outlining the background of this interest, some major aspects concerning degra

  8. Are graduate students rational? Evidence from the market for biomedical scientists.

    Science.gov (United States)

    Blume-Kohout, Margaret E; Clack, John W

    2013-01-01

    The U.S. National Institutes of Health (NIH) budget expansion from 1998 through 2003 increased demand for biomedical research, raising relative wages and total employment in the market for biomedical scientists. However, because research doctorates in biomedical sciences can often take six years or more to complete, the full labor supply response to such changes in market conditions is not immediate, but rather is observed over a period of several years. Economic rational expectations models assume that prospective students anticipate these future changes, and also that students take into account the opportunity costs of their pursuing graduate training. Prior empirical research on student enrollment and degree completions in science and engineering (S&E) fields indicates that "cobweb" expectations prevail: that is, at least in theory, prospective graduate students respond to contemporaneous changes in market wages and employment, but do not forecast further changes that will arise by the time they complete their degrees and enter the labor market. In this article, we analyze time-series data on wages and employment of biomedical scientists versus alternative careers, on completions of S&E bachelor's degrees and biomedical sciences PhDs, and on research expenditures funded both by NIH and by biopharmaceutical firms, to examine the responsiveness of the biomedical sciences labor supply to changes in market conditions. Consistent with previous studies, we find that enrollments and completions in biomedical sciences PhD programs are responsive to market conditions at the time of students' enrollment. More striking, however, is the close correspondence between graduate student enrollments and completions, and changes in availability of NIH-funded traineeships, fellowships, and research assistantships.

  9. Recent advances in biomedical applications of accelerator mass spectrometry.

    Science.gov (United States)

    Hah, Sang Soo; Henderson, Paul T; Turteltaub, Kenneth W

    2009-06-17

    The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS), an extremely sensitive nuclear physics technique for detection of very low-abundant, stable and long-lived isotopes, has now revolutionized high-sensitivity isotope detection in biomedical research, because it allows the direct determination of the amount of isotope in a sample rather than measuring its decay, and thus the quantitative analysis of the fate of the radiolabeled probes under the given conditions. Since AMS was first used in the early 90's for the analysis of biological samples containing enriched 14C for toxicology and cancer research, the biomedical applications of AMS to date range from in vitro to in vivo studies, including the studies of 1) toxicant and drug metabolism, 2) neuroscience, 3) pharmacokinetics, and 4) nutrition and metabolism of endogenous molecules such as vitamins. In addition, a new drug development concept that relies on the ultrasensitivity of AMS, known as human microdosing, is being used to obtain early human metabolism information of candidate drugs. These various aspects of AMS are reviewed and a perspective on future applications of AMS to biomedical research is provided.

  10. Recent advances in biomedical applications of accelerator mass spectrometry

    Directory of Open Access Journals (Sweden)

    Hah Sang

    2009-06-01

    Full Text Available Abstract The use of radioisotopes has a long history in biomedical science, and the technique of accelerator mass spectrometry (AMS, an extremely sensitive nuclear physics technique for detection of very low-abundant, stable and long-lived isotopes, has now revolutionized high-sensitivity isotope detection in biomedical research, because it allows the direct determination of the amount of isotope in a sample rather than measuring its decay, and thus the quantitative analysis of the fate of the radiolabeled probes under the given conditions. Since AMS was first used in the early 90's for the analysis of biological samples containing enriched 14C for toxicology and cancer research, the biomedical applications of AMS to date range from in vitro to in vivo studies, including the studies of 1 toxicant and drug metabolism, 2 neuroscience, 3 pharmacokinetics, and 4 nutrition and metabolism of endogenous molecules such as vitamins. In addition, a new drug development concept that relies on the ultrasensitivity of AMS, known as human microdosing, is being used to obtain early human metabolism information of candidate drugs. These various aspects of AMS are reviewed and a perspective on future applications of AMS to biomedical research is provided.

  11. Full text clustering and relationship network analysis of biomedical publications.

    Directory of Open Access Journals (Sweden)

    Renchu Guan

    Full Text Available Rapid developments in the biomedical sciences have increased the demand for automatic clustering of biomedical publications. In contrast to current approaches to text clustering, which focus exclusively on the contents of abstracts, a novel method is proposed for clustering and analysis of complete biomedical article texts. To reduce dimensionality, Cosine Coefficient is used on a sub-space of only two vectors, instead of computing the Euclidean distance within the space of all vectors. Then a strategy and algorithm is introduced for Semi-supervised Affinity Propagation (SSAP to improve analysis efficiency, using biomedical journal names as an evaluation background. Experimental results show that by avoiding high-dimensional sparse matrix computations, SSAP outperforms conventional k-means methods and improves upon the standard Affinity Propagation algorithm. In constructing a directed relationship network and distribution matrix for the clustering results, it can be noted that overlaps in scope and interests among BioMed publications can be easily identified, providing a valuable analytical tool for editors, authors and readers.

  12. Carbon nanotubes from synthesis to in vivo biomedical applications.

    Science.gov (United States)

    Sajid, Muhammad Imran; Jamshaid, Usama; Jamshaid, Talha; Zafar, Nadiah; Fessi, H; Elaissari, Abdelhamid

    2016-03-30

    Owing to their unique and interesting properties, extensive research round the globe has been carried out on carbon nanotubes and carbon nanotubes based systems to investigate their practical usefulness in biomedical applications. The results from these studies demonstrate a great promise in their use in targeted drug delivery systems, diagnostic techniques and in bio-analytical applications. Although, carbon nanotubes possess quite interesting properties, which make them potential candidates in the biomedical science, but they also have some inherent properties which arise great concern regarding their biosafety. In this comprehensive review, we have discussed different aspects of carbon nanotubes and carbon nanotube based systems related to biomedical applications. In the beginning, a short historical account of these tiny yet powerful particles is given followed by discussion regarding their types, properties, methods of synthesis, large scale production method, purification techniques and characterization aspects of carbon nanotubes. In the second part of the review, the functionalization of carbon nanotubes is reviewed in detail, which is not only important to make them biocompatible and stable in biological systems but also render them a great property of loading various biomolecules, diagnostic and therapeutic moieties resulting in diversified applications. In the final part of the review, emphasis is given on the pharmacokinetic aspects of carbon nanotubes including administration routes, absorption mechanisms, distribution and elimination of carbon nanotubes based systems. Lastly, a comprehensive account about the potential biomedical applications has been given followed by insights into the future.

  13. Biomedical ethics and the biomedical engineer: a review.

    Science.gov (United States)

    Saha, S; Saha, P S

    1997-01-01

    Biomedical engineering is responsible for many of the dramatic advances in modern medicine. This has resulted in improved medical care and better quality of life for patients. However, biomedical technology has also contributed to new ethical dilemmas and has challenged some of our moral values. Bioengineers often lack adequate training in facing these moral and ethical problems. These include conflicts of interest, allocation of scarce resources, research misconduct, animal experimentation, and clinical trials for new medical devices. This paper is a compilation of our previous published papers on these topics, and it summarizes many complex ethical issues that a bioengineer may face during his or her research career or professional practice. The need for ethics training in the education of a bioengineering student is emphasized. We also advocate the adoption of a code of ethics for bioengineers.

  14. Livestock in biomedical research: history, current status and future prospective.

    Science.gov (United States)

    Polejaeva, Irina A; Rutigliano, Heloisa M; Wells, Kevin D

    2016-01-01

    Livestock models have contributed significantly to biomedical and surgical advances. Their contribution is particularly prominent in the areas of physiology and assisted reproductive technologies, including understanding developmental processes and disorders, from ancient to modern times. Over the past 25 years, biomedical research that traditionally embraced a diverse species approach shifted to a small number of model species (e.g. mice and rats). The initial reasons for focusing the main efforts on the mouse were the availability of murine embryonic stem cells (ESCs) and genome sequence data. This powerful combination allowed for precise manipulation of the mouse genome (knockouts, knockins, transcriptional switches etc.) leading to ground-breaking discoveries on gene functions and regulation, and their role in health and disease. Despite the enormous contribution to biomedical research, mouse models have some major limitations. Their substantial differences compared with humans in body and organ size, lifespan and inbreeding result in pronounced metabolic, physiological and behavioural differences. Comparative studies of strategically chosen domestic species can complement mouse research and yield more rigorous findings. Because genome sequence and gene manipulation tools are now available for farm animals (cattle, pigs, sheep and goats), a larger number of livestock genetically engineered (GE) models will be accessible for biomedical research. This paper discusses the use of cattle, goats, sheep and pigs in biomedical research, provides an overview of transgenic technology in farm animals and highlights some of the beneficial characteristics of large animal models of human disease compared with the mouse. In addition, status and origin of current regulation of GE biomedical models is also reviewed.

  15. Branding the bio/biomedical engineering degree.

    Science.gov (United States)

    Voigt, Herbert F

    2011-01-01

    The future challenges to medical and biological engineering, sometimes referred to as biomedical engineering or simply bioengineering, are many. Some of these are identifiable now and others will emerge from time to time as new technologies are introduced and harnessed. There is a fundamental issue regarding "Branding the bio/biomedical engineering degree" that requires a common understanding of what is meant by a B.S. degree in Biomedical Engineering, Bioengineering, or Biological Engineering. In this paper we address some of the issues involved in branding the Bio/Biomedical Engineering degree, with the aim of clarifying the Bio/Biomedical Engineering brand.

  16. Advanced Methods of Biomedical Signal Processing

    CERN Document Server

    Cerutti, Sergio

    2011-01-01

    This book grew out of the IEEE-EMBS Summer Schools on Biomedical Signal Processing, which have been held annually since 2002 to provide the participants state-of-the-art knowledge on emerging areas in biomedical engineering. Prominent experts in the areas of biomedical signal processing, biomedical data treatment, medicine, signal processing, system biology, and applied physiology introduce novel techniques and algorithms as well as their clinical or physiological applications. The book provides an overview of a compelling group of advanced biomedical signal processing techniques, such as mult

  17. Advancing community stakeholder engagement in biomedical HIV prevention trials: principles, practices and evidence.

    Science.gov (United States)

    Newman, Peter A; Rubincam, Clara

    2014-12-01

    Community stakeholder engagement is foundational to fair and ethically conducted biomedical HIV prevention trials. Concerns regarding the ethical engagement of community stakeholders in HIV vaccine trials and early terminations of several international pre-exposure prophylaxis trials have fueled the development of international guidelines, such as UNAIDS' good participatory practice (GPP). GPP aims to ensure that stakeholders are effectively involved in all phases of biomedical HIV prevention trials. We provide an overview of the six guiding principles in the GPP and critically examine them in relation to existing social and behavioral science research. In particular, we highlight the challenges involved in operationalizing these principles on the ground in various global contexts, with a focus on low-income country settings. Increasing integration of social science in biomedical HIV prevention trials will provide evidence to advance a science of community stakeholder engagement to support ethical and effective practices informed by local realities and sociocultural differences.

  18. Liberal Arts Engineers: Applied Sciences at the University of North Carolina at Chapel Hill

    Science.gov (United States)

    McNeil, Laurie

    1997-03-01

    As a university without an engineering school, the University of North Carolina at Chapel Hill has sought ways to enhance its appeal to students interested in the sciences. Building on strong undergraduate and graduate programs in the physical and biomedical sciences, we have developed a program for students who are interested in the practical applications of the sciences, but desire more of a basic science focus than a typical engineering program would provide. We think of these students as "liberal arts engineers." The program leads to a B.S. degree in Applied Sciences, and is administered through the Curriculum in Applied and Materials Sciences. This interdisciplinary unit is composed of faculty with primary appointments in the departments of Physics and Astronomy, Chemistry, Computer Science, Biomedical Engineering, Dental Research, and Orthopaedics, among others. Students in the program pursue tracks in digital systems, electronic materials, biomaterials, and polymers. I will describe the program as it has evolved, and the outcome of our dozen years of experience with it. I will also touch on our graduate program in Materials Science, which we began in fall 1996.

  19. Carbon nanotubes: engineering biomedical applications.

    Science.gov (United States)

    Gomez-Gualdrón, Diego A; Burgos, Juan C; Yu, Jiamei; Balbuena, Perla B

    2011-01-01

    Carbon nanotubes (CNTs) are cylinder-shaped allotropic forms of carbon, most widely produced under chemical vapor deposition. They possess astounding chemical, electronic, mechanical, and optical properties. Being among the most promising materials in nanotechnology, they are also likely to revolutionize medicine. Among other biomedical applications, after proper functionalization carbon nanotubes can be transformed into sophisticated biosensing and biocompatible drug-delivery systems, for specific targeting and elimination of tumor cells. This chapter provides an introduction to the chemical and electronic structure and properties of single-walled carbon nanotubes, followed by a description of the main synthesis and post-synthesis methods. These sections allow the reader to become familiar with the specific characteristics of these materials and the manner in which these properties may be dependent on the specific synthesis and post-synthesis processes. The chapter ends with a review of the current biomedical applications of carbon nanotubes, highlighting successes and challenges.

  20. Biomedical Applications of Biodegradable Polyesters

    Directory of Open Access Journals (Sweden)

    Iman Manavitehrani

    2016-01-01

    Full Text Available The focus in the field of biomedical engineering has shifted in recent years to biodegradable polymers and, in particular, polyesters. Dozens of polyester-based medical devices are commercially available, and every year more are introduced to the market. The mechanical performance and wide range of biodegradation properties of this class of polymers allow for high degrees of selectivity for targeted clinical applications. Recent research endeavors to expand the application of polymers have been driven by a need to target the general hydrophobic nature of polyesters and their limited cell motif sites. This review provides a comprehensive investigation into advanced strategies to modify polyesters and their clinical potential for future biomedical applications.

  1. [Biomedical update in bioethics: a primordial ethical imperative].

    Science.gov (United States)

    Pastor, Luis Miguel

    2011-01-01

    In this brief article we continue our reflection about the relations that should exist between the knowledge of biomedical sciences and the development of bioethics. After stating the principle of not absolute concordance between empirical and philosophical data as well as the former data are partial truths and highly contextualized by the experiment, we propose a certain criteria that should govern the use of biomedical sciences in bioethics. These criteria are based on ability to distinguish the two areas of knowledge and, without confusing each other, achieve their integration in a new unit of knowledge. Approximating the two disciplines in this way each will be more able to accommodate the other. From contiguity to integration into a higher order unit, without that both losing their own nature. We conclude that not only this posture avoid the mistake of deducting the bioethics from experimental scientific date but also not to manipulate biomedical data based on previous philosophical positions. Furthermore we also reached a more comprehensive and real understanding of bioethics. This implies that both scientists and humanists that work in bioethics must live an ethical imperative in their research that we have described as essential. This consist in a continuously update in biomedicine for research and development the bioethics.

  2. New biomedical applications of radiocarbon

    Energy Technology Data Exchange (ETDEWEB)

    Davis, J.C.

    1990-12-01

    The potential of accelerator mass spectrometry (AMS) and radiocarbon in biomedical applications is being investigated by Lawrence Livermore National Laboratory (LLNL). A measurement of the dose-response curve for DNA damage caused by a carcinogen in mouse liver cells was an initial experiment. This demonstrated the sensitivity and utility of AMS for detecting radiocarbon tags and led to numerous follow-on experiments. The initial experiment and follow-on experiments are discussed in this report. 12 refs., 4 figs. (SM)

  3. Biomedical Applications of Biodegradable Polyesters

    OpenAIRE

    Iman Manavitehrani; Ali Fathi; Hesham Badr; Sean Daly; Ali Negahi Shirazi; Fariba Dehghani

    2016-01-01

    The focus in the field of biomedical engineering has shifted in recent years to biodegradable polymers and, in particular, polyesters. Dozens of polyester-based medical devices are commercially available, and every year more are introduced to the market. The mechanical performance and wide range of biodegradation properties of this class of polymers allow for high degrees of selectivity for targeted clinical applications. Recent research endeavors to expand the application of polymers have be...

  4. Biomedical devices and their applications

    CERN Document Server

    2004-01-01

    This volume introduces readers to the basic concepts and recent advances in the field of biomedical devices. The text gives a detailed account of novel developments in drug delivery, protein electrophoresis, estrogen mimicking methods and medical devices. It also provides the necessary theoretical background as well as describing a wide range of practical applications. The level and style make this book accessible not only to scientific and medical researchers but also to graduate students.

  5. The Ontology for Biomedical Investigations.

    Science.gov (United States)

    Bandrowski, Anita; Brinkman, Ryan; Brochhausen, Mathias; Brush, Matthew H; Bug, Bill; Chibucos, Marcus C; Clancy, Kevin; Courtot, Mélanie; Derom, Dirk; Dumontier, Michel; Fan, Liju; Fostel, Jennifer; Fragoso, Gilberto; Gibson, Frank; Gonzalez-Beltran, Alejandra; Haendel, Melissa A; He, Yongqun; Heiskanen, Mervi; Hernandez-Boussard, Tina; Jensen, Mark; Lin, Yu; Lister, Allyson L; Lord, Phillip; Malone, James; Manduchi, Elisabetta; McGee, Monnie; Morrison, Norman; Overton, James A; Parkinson, Helen; Peters, Bjoern; Rocca-Serra, Philippe; Ruttenberg, Alan; Sansone, Susanna-Assunta; Scheuermann, Richard H; Schober, Daniel; Smith, Barry; Soldatova, Larisa N; Stoeckert, Christian J; Taylor, Chris F; Torniai, Carlo; Turner, Jessica A; Vita, Randi; Whetzel, Patricia L; Zheng, Jie

    2016-01-01

    The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource (http://obi-ontology.org) providing details on the people, policies, and issues being addressed

  6. Writing biomedical manuscripts part I: fundamentals and general rules.

    Science.gov (United States)

    Ohwovoriole, A E

    2011-01-01

    It is a professional obligation for health researchers to investigate and communicate their findings to the medical community. The writing of a publishable scientific manuscript can be a daunting task for the beginner and to even some established researchers. Many manuscripts fail to get off the ground and/or are rejected. The writing task can be made easier and the quality improved by using and following simple rules and leads that apply to general scientific writing .The manuscript should follow a standard structure:(e.g. (Abstract) plus Introduction, Methods, Results, and Discussion/Conclusion, the IMRAD model. The authors must also follow well established fundamentals of good communication in science and be systematic in approach. The manuscript must move from what is currently known to what was unknown that was investigated using a hypothesis, research question or problem statement. Each section has its own style of structure and language of presentation. The beginning of writing a good manuscript is to do a good study design and to pay attention to details at every stage. Many manuscripts are rejected because of errors that can be avoided if the authors follow simple guidelines and rules. One good way to avoid potential disappointment in manuscript writing is to follow the established general rules along with those of the journal in which the paper is to be published. An important injunction is to make the writing precise, clear, parsimonious, and comprehensible to the intended audience. The purpose of this article is to arm and encourage potential biomedical authors with tools and rules that will enable them to write contemporary manuscripts, which can stand the rigorous peer review process. The expectations of standard journals, and common pitfalls the major elements of a manuscript are covered.

  7. ISIFC - dual Biomedical Engineering School.

    Science.gov (United States)

    Butterlin, Nadia; Soto-Romero, Georges; Duffaud, Jacques; Blagosklonov, Oleg

    2007-01-01

    The Superior Institute for Biomedical Engineering (ISIFC), created in 2001, is part of the Franche-Comté University and is accredited by the French Ministry of National Education. Its originality lies in its innovative course of studies, which trains engineers in the scientific and medical fields to get both competencies. The Institute therefore collaborates with the University Hospital Centre of Besançon (CHU), biomedical companies and National Research Centres (CNRS and INSERM). The dual expertise trainees will have acquired at the end of their 3 years course covers medical and biological skills, scientific and Technical expertises. ISIFC engineers answer to manufacturer needs for skilled scientific and technical staff in instrumentation and techniques adapted to diagnosis, therapeutics and medical control, as well as the needs of potential users for biomedical devices, whether they are doctors, hospital staff, patients, laboratories, etc... Both the skills and the knowledge acquired by an ISIFC engineer will enable him/her to fulfil functions of study, research and development in the industrial sector.

  8. Lead Poison Detection

    Science.gov (United States)

    1976-01-01

    With NASA contracts, Whittaker Corporations Space Science division has developed an electro-optical instrument to mass screen for lead poisoning. Device is portable and detects protoporphyrin in whole blood. Free corpuscular porphyrins occur as an early effect of lead ingestion. Also detects lead in urine used to confirm blood tests. Test is inexpensive and can be applied by relatively unskilled personnel. Similar Whittaker fluorometry device called "drug screen" can measure morphine and quinine in urine much faster and cheaper than other methods.

  9. Annual Report for 1981 to the DOE Office of the Assistant Secretary for Environmental Protection, Safety, and Emergency Preparedness. Part 2. Ecological Sciences. [Lead abstract

    Energy Technology Data Exchange (ETDEWEB)

    Vaughan, B.E.

    1982-02-01

    Separate abstracts were prepared for the 38 reports for this Pacific Northwest Laboratory Annual Report for 1981 to the DOE Office of Energy Research. This part dealt with research conducted in the ecological sciences.

  10. Biomedical engineering - A means to add new dimension to medicine and research

    Science.gov (United States)

    Doerr, D. F.

    1992-01-01

    Biomedical engineering is an evolving science that seeks to insert technically oriented and trained personnel to assist medical professionals in solving technological problems in the pursuit of innovations in the delivery of health care. Consequently, engineering solutions are brought to bear on problems that previously were outside the training of physicians and beyond the understanding or appreciation of the conventionally educated electrical or mechanical engineers. This physician/scientist/engineer team has a capability to extend medicine and research far beyond the capability of a single entity operating alone. How biomedical engineering has added a new dimension to medical science at the Kennedy Space Center is described.

  11. Efficient Retrieval of Text for Biomedical Domain using Expectation Maximization Algorithm

    Directory of Open Access Journals (Sweden)

    Sumit Vashishtha

    2011-11-01

    Full Text Available Data mining, a branch of computer science [1], is the process of extracting patterns from large data sets by combining methods from statistics and artificial intelligence with database management. Data mining is seen as an increasingly important tool by modern business to transform data into business intelligence giving an informational advantage. Biomedical text retrieval refers to text retrieval techniques applied to biomedical resources and literature available of the biomedical and molecular biology domain. The volume of published biomedical research, and therefore the underlying biomedical knowledge base, is expanding at an increasing rate. Biomedical text retrieval is a way to aid researchers in coping with information overload. By discovering predictive relationships between different pieces of extracted data, data-mining algorithms can be used to improve the accuracy of information extraction. However, textual variation due to typos, abbreviations, and other sources can prevent the productive discovery and utilization of hard-matching rules. Recent methods of soft clustering can exploit predictive relationships in textual data. This paper presents a technique for using soft clustering data mining algorithm to increase the accuracy of biomedical text extraction. Experimental results demonstrate that this approach improves text extraction more effectively that hard keyword matching rules.

  12. The Theory of Biomedical Knowledge Integration(Ⅳ)

    Institute of Scientific and Technical Information of China (English)

    BAO Han-fei

    2005-01-01

    This paper presented some philosophic viewpoints of the Theory of BMKI (The Theory of Biomedical Knowledge Integration), a new exploration in BioMedical Informatics. It discussed an evolutional relation from propositional calculus, predicate calculus, through framework, to neural network.. The differences in exclusivity and other natures were explored for physical systems (the real world), quasi-physical systems (the copies of the real world) and mental systems(the abstracts of the real world). Based on their behaviours in cognitive sciences and knowledge engineering, the new concepts quasi-infinity or -infinitesimal,potential knowledge,dynamic knowledge were introduced. This paper has also described so called "big-or" space which is the base of scientific understanding or association. Furthermore the paper put forward the viewpoint that "reasoning only can implement in an axiomatic space" and then outlined the building processes of such kind of space. At last so called "beacon-andcompass strategy" in BMKI was introduced.

  13. Biological and biomedical aspects of genetically modified food.

    Science.gov (United States)

    Celec, Peter; Kukucková, Martina; Renczésová, Veronika; Natarajan, Satheesh; Pálffy, Roland; Gardlík, Roman; Hodosy, Július; Behuliak, Michal; Vlková, Barbora; Minárik, Gabriel; Szemes, Tomás; Stuchlík, Stanislav; Turna, Ján

    2005-12-01

    Genetically modified (GM) foods are the product of one of the most progressive fields of science-biotechnology. There are major concerns about GM foods in the public; some of them are reasonable, some of them are not. Biomedical risks of GM foods include problems regarding the potential allergenicity, horizontal gene transfer, but environmental side effects on biodiversity must also be recognized. Numerous methods have been developed to assess the potential risk of every GM food type. Benefits of the first generation of GM foods were oriented towards the production process and companies, the second generation of GM foods offers, on contrary, various advantages and added value for the consumer. This includes improved nutritional composition or even therapeutic effects. Recombinant probiotics and the principle of alternative gene therapy represent the latest approach of using GM organisms for biomedical applications. This article tries to summarize and to explain the problematic topic of GM food.

  14. A general method for modeling biochemical and biomedical response

    Science.gov (United States)

    Ortiz, Roberto; Lerd Ng, Jia; Hughes, Tyler; Abou Ghantous, Michel; Bouhali, Othmane; Arredouani, Abdelilah; Allen, Roland

    2012-10-01

    The impressive achievements of biomedical science have come mostly from experimental research with human subjects, animal models, and sophisticated laboratory techniques. Additionally, theoretical chemistry has been a major aid in designing new drugs. Here we introduce a method which is similar to others already well known in theoretical systems biology, but which specifically addresses biochemical changes as the human body responds to medical interventions. It is common in systems biology to use first-order differential equations to model the time evolution of various chemical concentrations, and we as physicists can make a significant impact through designing realistic models and then solving the resulting equations. Biomedical research is rapidly advancing, and the technique presented in this talk can be applied in arbitrarily large models containing tens, hundreds, or even thousands of interacting species, to determine what beneficial effects and side effects may result from pharmaceuticals or other medical interventions.

  15. Lead Poisoning

    Science.gov (United States)

    Lead is a metal that occurs naturally in the earth's crust. Lead can be found in all parts of our ... from human activities such as mining and manufacturing. Lead used to be in paint; older houses may ...

  16. The Central Importance of Laboratories for Reducing Waste in Biomedical Research.

    Science.gov (United States)

    Stroth, Nikolas

    2016-12-01

    The global biomedical research enterprise is driving substantial advances in medicine and healthcare. Yet it appears that the enterprise is rather wasteful, falling short of its true innovative potential. Suggested reasons are manifold and involve various stakeholders, such that there is no single remedy. In the present paper, I will argue that laboratories are the basic working units of the biomedical research enterprise and an important site of action for corrective intervention. Keeping laboratories relatively small will enable better training and mentoring of individual scientists, which in turn will yield better performance of the scientific workforce. The key premise of this argument is that people are at the heart of the successes and failures of biomedical research, yet the human dimension of science has been unduly neglected in practice. Renewed focus on the importance of laboratories and their constituent scientists is one promising approach to reducing waste and increasing efficiency within the biomedical research enterprise.

  17. Teaching Research Integrity and Bioethics to Science Undergraduates

    Science.gov (United States)

    Turrens, Julio F.

    2005-01-01

    Undergraduate students in the Department of Biomedical Sciences at the University of South Alabama, Mobile, are required to take a course entitled "Issues in Biomedical Sciences," designed to increase students' awareness about bioethical questions and issues concerning research integrity. This paper describes the main features of this…

  18. Text mining patents for biomedical knowledge.

    Science.gov (United States)

    Rodriguez-Esteban, Raul; Bundschus, Markus

    2016-06-01

    Biomedical text mining of scientific knowledge bases, such as Medline, has received much attention in recent years. Given that text mining is able to automatically extract biomedical facts that revolve around entities such as genes, proteins, and drugs, from unstructured text sources, it is seen as a major enabler to foster biomedical research and drug discovery. In contrast to the biomedical literature, research into the mining of biomedical patents has not reached the same level of maturity. Here, we review existing work and highlight the associated technical challenges that emerge from automatically extracting facts from patents. We conclude by outlining potential future directions in this domain that could help drive biomedical research and drug discovery.

  19. Lead Toxicity

    Science.gov (United States)

    ... including some imported jewelry. What are the health effects of lead? • More commonly, lower levels of lead in children over time may lead to reduced IQ, slow learning, Attention Deficit Hyperactivity Disorder (ADHD), or behavioral issues. • Lead also affects other ...

  20. Novel Hyperbranched Polyurethane Brushes for Biomedical Applications

    Institute of Scientific and Technical Information of China (English)

    Ton; Loontjens; Bart; Plum

    2007-01-01

    1 Results The objective was to make hyperbranched (HB) polyurethane brushes with reactive end groups, to coat biomedical devices and to enable the introduction of various functionalities that are needed to fulfill biomedical tasks.Biomedical materials should fulfill at least three requirements: (1) good mechanical properties, (2) good biocompatibility and (3) provided with functionalities to perform the required tasks. Since polyurethanes are able to fulfill the first 2 requirements we focused in this w...

  1. Biomedical signal and image processing

    CERN Document Server

    Najarian, Kayvan

    2012-01-01

    INTRODUCTION TO DIGITAL SIGNAL AND IMAGE PROCESSINGSignals and Biomedical Signal ProcessingIntroduction and OverviewWhat is a ""Signal""?Analog, Discrete, and Digital SignalsProcessing and Transformation of SignalsSignal Processing for Feature ExtractionSome Characteristics of Digital ImagesSummaryProblemsFourier TransformIntroduction and OverviewOne-Dimensional Continuous Fourier TransformSampling and NYQUIST RateOne-Dimensional Discrete Fourier TransformTwo-Dimensional Discrete Fourier TransformFilter DesignSummaryProblemsImage Filtering, Enhancement, and RestorationIntroduction and Overview

  2. An introduction to biomedical instrumentation

    CERN Document Server

    Dewhurst, D J

    1976-01-01

    An Introduction to Biomedical Instrumentation presents a course of study and applications covering the basic principles of medical and biological instrumentation, as well as the typical features of its design and construction. The book aims to aid not only the cognitive domain of the readers, but also their psychomotor domain as well. Aside from the seminar topics provided, which are divided into 27 chapters, the book complements these topics with practical applications of the discussions. Figures and mathematical formulas are also given. Major topics discussed include the construction, handli

  3. Thermoresponsive Polymers for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Theoni K. Georgiou

    2011-08-01

    Full Text Available Thermoresponsive polymers are a class of “smart” materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

  4. Microfabrication materials for biomedical microdevices

    Science.gov (United States)

    Hansford, Derek James

    Major hurdles to the implementation of microfabricated devices for therapeutic applications include materials processing and biocompatibility issues. This dissertation reports research on improving the materials selection and fabrication for biomedical microdevices, using a microfabricated immunoisolation biocapsule as an example. Two material classes in the microfabrication protocol were examined based on the requirements determined for biomedical microdevices: the adhesive layer for bonding devices to encapsulate delicate biological substances and the thin film structural materials for surface structures, such as the biocapsule membrane. The major requirements for the adhesive layer material included non-cytotoxicity during bonding, adhesive strength, and durability under physiological conditions. Low glassy-phase transition temperature (Tg) methacrylates were found to be suitable candidates for adhesives of biomedical microdevices. A comparison study of poly propy1methacrylate (PPMA), poly (butyl, ethyl) methacrylate (PBEMA), and the higher Tg PMMA showed that all of the methacrylates had similar biocompatibility, adhesive strength, and durability. The adhesive strengths were found to be suitable for the adhesion of biomedical microdevices, as shown by measurement using a pressurized plate test and the current use of PMMA as bone cement. None of the methacrylates showed evidence of cytotoxicity, as measured by both optical and cytometric cell culture cytotoxicity tests. A protocol for the selective placement of smooth, thin films of PPMA using a Gel-PakTM transfer substrate was developed and demonstrated. The major requirements determined for the thin film structural materials were based on processing, mechanical, and biological parameters. Several candidates were identified as for structural materials based on these requirements: polycrystalline silicon. silicon nitride, fluoropolymers, PMMA, and silicone. A new fabrication protocol was developed to allow the

  5. Review of Biomedical Image Processing

    Directory of Open Access Journals (Sweden)

    Ciaccio Edward J

    2011-11-01

    Full Text Available Abstract This article is a review of the book: 'Biomedical Image Processing', by Thomas M. Deserno, which is published by Springer-Verlag. Salient information that will be useful to decide whether the book is relevant to topics of interest to the reader, and whether it might be suitable as a course textbook, are presented in the review. This includes information about the book details, a summary, the suitability of the text in course and research work, the framework of the book, its specific content, and conclusions.

  6. Introduction to biomedical engineering technology

    CERN Document Server

    Street, Laurence J

    2011-01-01

    IntroductionHistory of Medical DevicesThe Role of Biomedical Engineering Technologists in Health CareCharacteristics of Human Anatomy and Physiology That Relate to Medical DevicesSummaryQuestionsDiagnostic Devices: Part OnePhysiological Monitoring SystemsThe HeartSummaryQuestionsDiagnostic Devices: Part TwoCirculatory System and BloodRespiratory SystemNervous SystemSummaryQuestionsDiagnostic Devices: Part ThreeDigestive SystemSensory OrgansReproductionSkin, Bone, Muscle, MiscellaneousChapter SummaryQuestionsDiagnostic ImagingIntroductionX-RaysMagnetic Resonance Imaging ScannersPositron Emissio

  7. Biomedical engineering principles of modern cochlear implants and recent surgical innovations.

    Science.gov (United States)

    Eshraghi, Adrien A; Gupta, Chhavi; Ozdamar, Ozcan; Balkany, Thomas J; Truy, Eric; Nazarian, Ronen

    2012-11-01

    This review covers the most recent clinical and surgical advances made in the development and application of cochlear implants (CIs). In recent years, dramatic progress has been made in both clinical and basic science aspect of cochlear implantation. Today's modern CI uses multi-channel electrodes with highly miniaturized powerful digital processing chips. This review article describes the function of various components of the modern multi-channel CIs. A selection of the most recent clinical and surgical innovations is presented. This includes the preliminary results with electro-acoustic stimulation or hybrid devices and ongoing basic science research that is focused on the preservation of residual hearing post-implantation. The result of an original device that uses a binaural stimulation mode with a single implanted receiver/stimulator is also presented. The benefit and surgical design of a temporalis pocket technique for the implant's receiver stimulator is discussed. Advances in biomedical engineering and surgical innovations that lead to an increasingly favorable clinical outcome and to an expansion of the indication of CI surgery are presented and discussed.

  8. Telemedicine optoelectronic biomedical data processing system

    Science.gov (United States)

    Prosolovska, Vita V.

    2010-08-01

    The telemedicine optoelectronic biomedical data processing system is created to share medical information for the control of health rights and timely and rapid response to crisis. The system includes the main blocks: bioprocessor, analog-digital converter biomedical images, optoelectronic module for image processing, optoelectronic module for parallel recording and storage of biomedical imaging and matrix screen display of biomedical images. Rated temporal characteristics of the blocks defined by a particular triggering optoelectronic couple in analog-digital converters and time imaging for matrix screen. The element base for hardware implementation of the developed matrix screen is integrated optoelectronic couples produced by selective epitaxy.

  9. Frontiers in biomedical engineering and biotechnology.

    Science.gov (United States)

    Liu, Feng; Goodarzi, Ali; Wang, Haifeng; Stasiak, Joanna; Sun, Jianbo; Zhou, Yu

    2014-01-01

    The 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013), held in Wuhan on 11–13 October 2013, is an annual conference that aims at providing an opportunity for international and national researchers and practitioners to present the most recent advances and future challenges in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The papers published by this issue are selected from this conference, which witnesses the frontier in the field of Biomedical Engineering and Biotechnology, which particularly has helped improving the level of clinical diagnosis in medical work.

  10. Imaging sciences workshop

    Energy Technology Data Exchange (ETDEWEB)

    Candy, J.V.

    1994-11-15

    This workshop on the Imaging Sciences sponsored by Lawrence Livermore National Laboratory contains short abstracts/articles submitted by speakers. The topic areas covered include the following: Astronomical Imaging; biomedical imaging; vision/image display; imaging hardware; imaging software; Acoustic/oceanic imaging; microwave/acoustic imaging; computed tomography; physical imaging; imaging algorithms. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

  11. Hypercompetition in biomedical research evaluation and its impact on young scientist careers.

    Science.gov (United States)

    Kamerlin, Shina Caroline Lynn

    2015-12-01

    Recent years have seen tremendous changes in the modes of publication and dissemination of biomedical information, with the introduction of countless new publishers and publishing models, as well as alternative modes of research evaluation. In parallel, we are witnessing an unsustainable explosion in the amount of information generated by each individual scientist, at the same time as many countries' shrinking research budgets are greatly increasing the competition for research funding. In such a hypercompetitive environment, how does one measure excellence? This contribution will provide an overview of some of the ongoing changes in authorship practices in the biomedical sciences, and also the consequences of hypercompetition to the careers of young scientists, from the perspective of a tenured young faculty member in the biomedical sciences. It will also provide some suggestions as to alternate dissemination and evaluation practices that could reverse current trends. [Int Microbiol 18(4):253-261 (2015)].

  12. Phytofabricated gold nanoparticles and their biomedical applications.

    Science.gov (United States)

    Ahmad, Bashir; Hafeez, Nabia; Bashir, Shumaila; Rauf, Abdur; Mujeeb-Ur-Rehman

    2017-02-26

    In a couple of decades, nanotechnology has become a trending technology owing to its integrated science collection that incorporates variety of fields such as chemistry, physics, medicine, catalytic processes, food processing industries, electronics and energy sectors. One of the emerging fields of nanotechnology that has gained momentous admiration is nano-biotechnology. Nano-biotechnology is an integrated combination of biology with nanotechnology that encompasses the tailoring, and synthesis of small particles that are less than 100nm in size and subsequent exploitation of these particles for their biological applications. Though the variety of physical techniques and chemical procedures are known for the nanoparticles synthesis, biological approach is considered to be the preferred one. Environmental hazards and concerns associated with the physical and chemical approaches of nanoparticles synthesis has added impetus and zenith to the biological approach involving the use of plants and microorganisms. The current review article is focused on the synthesis of plant-derived (phytochemical) gold nanoparticles alongside their scope in biomedical applications.

  13. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry.

  14. Legacy of Biomedical Research During the Space Shuttle Program

    Science.gov (United States)

    Hayes, Judith C.

    2011-01-01

    The Space Shuttle Program provided many opportunities to study the role of spaceflight on human life for over 30 years and represented the longest and largest US human spaceflight program. Outcomes of the research were understanding the effect of spaceflight on human physiology and performance, countermeasures, operational protocols, and hardware. The Shuttle flights were relatively short, Biomedical research was conducted on the Space Shuttle using various vehicle resources. Specially constructed pressurized laboratories called Spacelab and SPACEHAB housed many laboratory instruments to accomplish experiments in the Shuttle s large payload bay. In addition to these laboratory flights, nearly every mission had dedicated human life science research experiments conducted in the Shuttle middeck. Most Shuttle astronauts participated in some life sciences research experiments either as test subjects or test operators. While middeck experiments resulted in a low sample per mission compared to many Earth-based studies, this participation allowed investigators to have repetition of tests over the years on successive Shuttle flights. In addition, as a prelude to the International Space Station (ISS), NASA used the Space Shuttle as a platform for assessing future ISS hardware systems and procedures. The purpose of this panel is to provide an understanding of science integration activities required to implement Shuttle research, review biomedical research, characterize countermeasures developed for Shuttle and ISS as well as discuss lessons learned that may support commercial crew endeavors. Panel topics include research integration, cardiovascular physiology, neurosciences, skeletal muscle, and exercise physiology. Learning Objective: The panel provides an overview from the Space Shuttle Program regarding research integration, scientific results, lessons learned from biomedical research and countermeasure development.

  15. Biomedical information retrieval across languages.

    Science.gov (United States)

    Daumke, Philipp; Markü, Kornél; Poprat, Michael; Schulz, Stefan; Klar, Rüdiger

    2007-06-01

    This work presents a new dictionary-based approach to biomedical cross-language information retrieval (CLIR) that addresses many of the general and domain-specific challenges in current CLIR research. Our method is based on a multilingual lexicon that was generated partly manually and partly automatically, and currently covers six European languages. It contains morphologically meaningful word fragments, termed subwords. Using subwords instead of entire words significantly reduces the number of lexical entries necessary to sufficiently cover a specific language and domain. Mediation between queries and documents is based on these subwords as well as on lists of word-n-grams that are generated from large monolingual corpora and constitute possible translation units. The translations are then sent to a standard Internet search engine. This process makes our approach an effective tool for searching the biomedical content of the World Wide Web in different languages. We evaluate this approach using the OHSUMED corpus, a large medical document collection, within a cross-language retrieval setting.

  16. Biomedical applications of control engineering

    CERN Document Server

    Hacısalihzade, Selim S

    2013-01-01

    Biomedical Applications of Control Engineering is a lucidly written textbook for graduate control engin­eering and biomedical engineering students as well as for medical prac­ti­tioners who want to get acquainted with quantitative methods. It is based on decades of experience both in control engineering and clinical practice.   The book begins by reviewing basic concepts of system theory and the modeling process. It then goes on to discuss control engineering application areas like ·         Different models for the human operator, ·         Dosage and timing optimization in oral drug administration, ·         Measuring symptoms of and optimal dopaminergic therapy in Parkinson’s disease, ·         Measure­ment and control of blood glucose le­vels both naturally and by means of external controllers in diabetes, and ·         Control of depth of anaesthesia using inhalational anaesthetic agents like sevoflurane using both fuzzy and state feedback controllers....

  17. ENLIGHT and LEIR biomedical facility.

    Science.gov (United States)

    Dosanjh, M; Cirilli, M; Navin, S

    2014-07-01

    Particle therapy (including protons and carbon ions) allows a highly conformal treatment of deep-seated tumours with good accuracy and minimal dose to surrounding tissues, compared to conventional radiotherapy using X-rays. Following impressive results from early phase trials, over the last decades particle therapy in Europe has made considerable progress in terms of new institutes dedicated to charged particle therapy in several countries. Particle therapy is a multidisciplinary subject that involves physicists, biologists, radio-oncologists, engineers and computer scientists. The European Network for Light Ion Hadron Therapy (ENLIGHT) was created in response to the growing needs of the European community to coordinate such efforts. A number of treatment centres are already operational and treating patients across Europe, including two dual ion (protons and carbon ions) centres in Heidelberg (the pioneer in Europe) and Pavia. However, much more research needs to be carried out and beamtime is limited. Hence there is a strong interest from the biomedical research community to have a facility with greater access to relevant beamtime. Such a facility would facilitate research in radiobiology and the development of more accurate techniques of dosimetry and imaging. The Low Energy Ion Ring (LEIR) accelerator at CERN presents such an opportunity, and relies partly on CERN's existing infrastructure. The ENLIGHT network, European Commission projects under the ENLIGHT umbrella and the future biomedical facility are discussed.

  18. The Role of Scientific Communication Skills in Trainees' Intention to Pursue Biomedical Research Careers: A Social Cognitive Analysis.

    Science.gov (United States)

    Cameron, Carrie; Lee, Hwa Young; Anderson, Cheryl; Byars-Winston, Angela; Baldwin, Constance D; Chang, Shine

    2015-01-01

    Scientific communication (SciComm) skills are indispensable for success in biomedical research, but many trainees may not have fully considered the necessity of regular writing and speaking for research career progression. Our purpose was to investigate the relationship between SciComm skill acquisition and research trainees' intentions to remain in research careers. We used social cognitive career theory (SCCT) to test a model of the relationship of SciComm skills to SciComm-related cognitive variables in explaining career intentions. A sample of 510 graduate students and postdoctoral fellows at major academic health science centers in the Texas Medical Center, Houston, Texas, were surveyed online. Results suggested that interest in performing SciComm tasks, SciComm outcome expectations (SCOEs), and SciComm productivity predicted intention to remain in a research career, while SciComm self-efficacy did not directly predict career intention. SCOEs also predicted interest in performing SciComm tasks. As in other SCCT studies, SciComm self-efficacy predicted SCOEs. We conclude that social cognitive factors of SciComm skill acquisition and SciComm productivity significantly predict biomedical trainees' intentions to pursue research careers whether within or outside academia. While further studies are needed, these findings may lead to evidence-based interventions to help trainees remain in their chosen career paths.

  19. Enhancing Graduate and Postdoctoral Education To Create a Sustainable Biomedical Workforce.

    Science.gov (United States)

    Fuhrmann, Cynthia N

    2016-11-01

    PhD-trained biomedical scientists are moving into an increasingly diverse variety of careers within the sciences. However, graduate and postdoctoral training programs have historically focused on academic career preparation, and have not sufficiently prepared trainees for transitioning into other scientific careers. Advocates for science have raised the concern that the collective disregard of the broader career-development needs for predoctoral and postdoctoral trainees could drive talent away from science in upcoming generations. A shift is occurring, wherein universities are increasingly investing in centralized career development programs to address this need. In this Perspective, I reflect on the movement that brought biomedical PhD career development to the spotlight in recent years, and how this movement has influenced both the academic biomedical community and the field of career development. I offer recommendations for universities looking to establish or strengthen their career development programs, including recommendations for how to develop a campus culture that values career development as part of pre- and postdoctoral training. I also suggest steps that faculty might take to facilitate the career development of their mentees, regardless of the mentee's career aspirations. Finally, I reflect on recent national efforts to incentivize innovation, evaluation, and research in the field of biomedical PhD career development, and propose actions that the scientific community can take to support biomedical career development further as a scholarly discipline. These investments will enable new approaches to be rigorously tested and efficiently disseminated to support this rapidly growing field. Ultimately, strengthening biomedical career development will be essential for attracting the best talent to science and helping them efficiently move into careers that will sustain our nation's scientific enterprise.

  20. Tooth regeneration: challenges and opportunities for biomedical material research.

    Science.gov (United States)

    Du, Chang; Moradian-Oldak, Janet

    2006-03-01

    Tooth regeneration presents many challenges to researchers in the fields of biology, medicine and material science. This review considers the opportunities for biomedical material research to contribute to this multidisciplinary endeavor. We present short summaries and an overview on the collective knowledge of tooth developmental biology, advances in stem-cell research, and progress in the understanding of the tooth biomineralization principles as they provide the foundation for developing strategies for reparative and regenerative medicine. We emphasize that various biomaterials developed via biomimetic strategies have great potential for tooth tissue engineering and regeneration applications. The current practices in tooth tissue engineering approaches and applications of biomimetic carriers or scaffolds are also discussed.

  1. Introduction to fiber optics: Sensors for biomedical applications.

    Science.gov (United States)

    Shah, R Y; Agrawal, Y K

    2011-01-01

    The paper focuses on the introduction of fiber optics, a fusion of science and engineering and describes the materials generally used for its construction along with the procedure used to design the fibers. It gives an idea of the materials used for the construction along with the pros and cons associated with them and various factors governing the emission of ultraviolet, infrared or visible radiations. The central core revolves around the applications of optical fibers in the medical and biomedical field and extending the use of the same in pharmaceutical industry as probes in quality control and dosage form analysis.

  2. Reaping the benefits of biomedical research: partnerships required.

    Science.gov (United States)

    Portilla, Lili M; Alving, Barbara

    2010-06-09

    Reaping the benefits of investments in biomedical research can be achieved most efficiently through active collaboration among industry, academia, government, and nonprofit organizations. The National Institutes of Health (NIH) are exploring multiple ways in which to increase the efficiency of the translational process. Investigators involved in the NIH-funded Clinical and Translational Science Awards are developing public-private partnerships, addressing the barriers to collaboration, training the next generation of interdisciplinary team-oriented researchers, and producing open-source tools for collaboration. NIH is engaging with industry through the Foundation for the NIH and the Small Business Innovation Research Awards.

  3. Environmental and biomedical applications of natural metal stable isotope variations

    Science.gov (United States)

    Bullen, T.D.; Walczyk, T.

    2009-01-01

    etal stable isotopes are now being used to trace metal contaminants in the environment and as indicators of human systemic function where metals play a role. Stable isotope abundance variations provide information about metal sources and the processes affecting metals in complex natural systems, complementing information gained from surrogate tracers, such as metal abundance ratios or biochemical markers of metal metabolism. The science is still in its infancy, but the results of initial studies confirm that metal stable isotopes can provide a powerful tool for forensic and biomedical investigations.

  4. Lab-on-a-chip techniques, circuits, and biomedical applications

    CERN Document Server

    Ghallab, Yehya H

    2010-01-01

    Here's a groundbreaking book that introduces and discusses the important aspects of lab-on-a-chip, including the practical techniques, circuits, microsystems, and key applications in the biomedical, biology, and life science fields. Moreover, this volume covers ongoing research in lab-on-a-chip integration and electric field imaging. Presented in a clear and logical manner, the book provides you with the fundamental underpinnings of lab-on-a-chip, presents practical results, and brings you up to date with state-of-the-art research in the field. This unique resource is supported with over 160 i

  5. Announcement of new division: C9 – Biomedical, Health-Beneficial, and Nutritionally Enhanced Plants

    Science.gov (United States)

    Crop Science, is pleased to announce that manuscript submissions are now being accepted to the journal through the new Provisional Division C09 – Biomedical, Health-Beneficial, and Nutritionally Enhanced Plants. The focus of this Division is on plants as food or feed, and on the development and eva...

  6. Peer Relationships and the Biomedical Doctorate: A Key Component of the Contemporary Learning Environment

    Science.gov (United States)

    Kemp, Matthew W.; Molloy, Timothy J.; Pajic, Marina; Chapman, Elaine

    2013-01-01

    Little attention has been paid to the scholarship of doctoral education in the biomedical sciences, hindering the formulation of research-informed improvements to this important area of higher education. We present an analysis of interview data from Australian PhD students and suggest that relationships between students and their…

  7. Analysis of Uncertainty and Variability in Finite Element Computational Models for Biomedical Engineering: Characterization and Propagation.

    Science.gov (United States)

    Mangado, Nerea; Piella, Gemma; Noailly, Jérôme; Pons-Prats, Jordi; Ballester, Miguel Ángel González

    2016-01-01

    Computational modeling has become a powerful tool in biomedical engineering thanks to its potential to simulate coupled systems. However, real parameters are usually not accurately known, and variability is inherent in living organisms. To cope with this, probabilistic tools, statistical analysis and stochastic approaches have been used. This article aims to review the analysis of uncertainty and variability in the context of finite element modeling in biomedical engineering. Characterization techniques and propagation methods are presented, as well as examples of their applications in biomedical finite element simulations. Uncertainty propagation methods, both non-intrusive and intrusive, are described. Finally, pros and cons of the different approaches and their use in the scientific community are presented. This leads us to identify future directions for research and methodological development of uncertainty modeling in biomedical engineering.

  8. Magnetic Resonance Imaging in Biomedical Engineering

    Science.gov (United States)

    Kaśpar, Jan; Hána, Karel; Smrčka, Pavel; Brada, Jiří; Beneš, Jiří; Šunka, Pavel

    2007-11-01

    The basic principles of magnetic resonance imaging covering physical principles and basic imaging techniques will be presented as a strong tool in biomedical engineering. Several applications of MRI in biomedical research practiced at the MRI laboratory of the FBMI CTU including other laboratory instruments and activities are introduced.

  9. Biomedical engineering research at DOE national labs

    Energy Technology Data Exchange (ETDEWEB)

    None

    1999-03-01

    Biomedical Engineering is the application of principles of physics, chemistry, nd engineering to problems of human health. The National Laboratories of the U.S. Department of Energy have been leaders in this scientific field since 1947. This inventory of their biomedical engineering projects was compiled in January 1999.

  10. Cross language information retrieval for biomedical literature

    NARCIS (Netherlands)

    Schuemie, M.; Trieschnigg, D.; Kraaij, W.

    2007-01-01

    This workshop report discusses the collaborative work of UT, EMC and TNO on the TREC Genomics Track 2007. The biomedical information retrieval task is approached using cross language methods, in which biomedical concept detection is combined with effective IR based on unigram language models. Furthe

  11. Locally Learning Biomedical Data Using Diffusion Frames

    Science.gov (United States)

    2012-01-01

    expands, increasingly detailed biomedical data must be integrated to betterunderstand normal function and evolution of multifactorial chronic disease ...1259 approach on two standard datasets, we aimed to classify and predict disease progression in AMD patients. Drusen were classified in multispectral...early disease stages in standard and new biomedical datasets. Key words: graphs and networks, machine learning. 1. INTRODUCTION As personalized medicine

  12. Science Bubbles

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella; Pedersen, David Budtz

    2013-01-01

    Much like the trade and trait sof bubbles in financial markets,similar bubbles appear on the science market. When economic bubbles burst, the drop in prices causes the crash of unsustainable investments leading to an investor confidence crisis possibly followed by a financial panic. But when...... bubbles appear in science, truth and reliability are the first victims. This paper explores how fashions in research funding and research management may turn science into something like a bubble economy....

  13. Biomedical informatics research network: building a national collaboratory to hasten the derivation of new understanding and treatment of disease.

    Science.gov (United States)

    Grethe, Jeffrey S; Baru, Chaitan; Gupta, Amarnath; James, Mark; Ludaescher, Bertram; Martone, Maryann E; Papadopoulos, Philip M; Peltier, Steven T; Rajasekar, Arcot; Santini, Simone; Zaslavsky, Ilya N; Ellisman, Mark H

    2005-01-01

    Through support from the National Institutes of Health's National Center for Research Resources, the Biomedical Informatics Research Network (BIRN) is pioneering the use of advanced cyberinfrastructure for medical research. By synchronizing developments in advanced wide area networking, distributed computing, distributed database federation, and other emerging capabilities of e-science, the BIRN has created a collaborative environment that is paving the way for biomedical research and clinical information management. The BIRN Coordinating Center (BIRN-CC) is orchestrating the development and deployment of key infrastructure components for immediate and long-range support of biomedical and clinical research being pursued by domain scientists in three neuroimaging test beds.

  14. An evaluative conservative case for biomedical enhancement.

    Science.gov (United States)

    Danaher, John

    2016-09-01

    It is widely believed that a conservative moral outlook is opposed to biomedical forms of human enhancement. In this paper, I argue that this widespread belief is incorrect. Using Cohen's evaluative conservatism as my starting point, I argue that there are strong conservative reasons to prioritise the development of biomedical enhancements. In particular, I suggest that biomedical enhancement may be essential if we are to maintain our current evaluative equilibrium (ie, the set of values that undergird and permeate our current political, economic and personal lives) against the threats to that equilibrium posed by external, non-biomedical forms of enhancement. I defend this view against modest conservatives who insist that biomedical enhancements pose a greater risk to our current evaluative equilibrium, and against those who see no principled distinction between the forms of human enhancement.

  15. Applications of computational intelligence in biomedical technology

    CERN Document Server

    Majernik, Jaroslav; Pancerz, Krzysztof; Zaitseva, Elena

    2016-01-01

    This book presents latest results and selected applications of Computational Intelligence in Biomedical Technologies. Most of contributions deal with problems of Biomedical and Medical Informatics, ranging from theoretical considerations to practical applications. Various aspects of development methods and algorithms in Biomedical and Medical Informatics as well as Algorithms for medical image processing, modeling methods are discussed. Individual contributions also cover medical decision making support, estimation of risks of treatments, reliability of medical systems, problems of practical clinical applications and many other topics  This book is intended for scientists interested in problems of Biomedical Technologies, for researchers and academic staff, for all dealing with Biomedical and Medical Informatics, as well as PhD students. Useful information is offered also to IT companies, developers of equipment and/or software for medicine and medical professionals.  .

  16. Design and analysis of biomedical studies

    DEFF Research Database (Denmark)

    Hansen, Merete Kjær

    Biomedicine is a field that has great influence on the majority of mankind. The constant development has considerably changed our way of life during the last centuries. This has been achieved through the dedication of biomedical researchers along with the tremendous ressources that over time have...... been allocated this field. It is utterly important to utilize these ressources responsibly and efficiently by constantly striving to ensure high-quality biomedical studies. This involves the use of a sound statistical methodology regarding both the design and analysis of biomedical studies. The focus...... for biomedical studies are a recurring theme in this thesis. Data collected in some biomedical studies are positively skewed; hence methods relying on the normal distribution are not directly applicable. We investigated how data from one of these studies are suitably analyzed. We extracted 23 different summary...

  17. Current state of biomedical engineering; Biomedical Engineering ha ima

    Energy Technology Data Exchange (ETDEWEB)

    Sakai, K. [Waseda Univ., Tokyo (Japan). School of Science and Engineering; Kanamori, T. [National Inst. of Materials and Chemical Research, Tsukuba (Japan)

    1996-11-05

    Medical science is divided into basic medical science and clinical medicine, and the technology of the medical treatment is established as their aggregate power. This concept can be compared with the presence of industrial engineering as a product of physical science and engineering. Basic medical science has come to be combined with science deeply as a result of the rise of recent molecular biology. As to clinical medicine, current highly advanced medical treatment can be said to be made up of scientific technology. Medical treatment can be considered to include prevention, diagnosis, remedy, and rehabilitation stages. It is closely connected with engineering in each stage. The methods of approaching medical science are elucidation of the functions of internal organs and tissue considering that a living body is a plant, and offering of new therapeutical means by applying chemical devices to a living body. The functions of artificial organs can e divided roughly into convection transport, mass transfer, structural members, and signal transfer from the viewpoint of chemical engineering. Medical treatment will be brought into close relation with scientific technology in the future. 10 refs., 3 figs., 2 tabs.

  18. Animals in biomedical space research

    Science.gov (United States)

    Phillips, Robert W.

    The use of experimental animals has been a major component of biomedical research progress. Using animals in space presents special problems, but also provides special opportunities. Rat and squirrel monkeys experiments have been planned in concert with human experiments to help answer fundamental questions concerning the effect of weightlessness on mammalian function. For the most part, these experiments focus on identified changes noted in humans during space flight. Utilizing space laboratory facilities, manipulative experiments can be completed while animals are still in orbit. Other experiments are designed to study changes in gravity receptor structure and function and the effect of weightlessness on early vertebrate development. Following these preliminary animals experiments on Spacelab Shuttle flights, longer term programs of animal investigation will be conducted on Space Station.

  19. Piezoelectric nanomaterials for biomedical applications

    CERN Document Server

    Menciassi, Arianna

    2012-01-01

    Nanoscale structures and materials have been explored in many biological applications because of their novel and impressive physical and chemical properties. Such properties allow remarkable opportunities to study and interact with complex biological processes. This book analyses the state of the art of piezoelectric nanomaterials and introduces their applications in the biomedical field. Despite their impressive potentials, piezoelectric materials have not yet received significant attention for bio-applications. This book shows that the exploitation of piezoelectric nanoparticles in nanomedicine is possible and realistic, and their impressive physical properties can be useful for several applications, ranging from sensors and transducers for the detection of biomolecules to “sensible” substrates for tissue engineering or cell stimulation.

  20. Biomedical Perspective of Electrochemical Nanobiosensor

    Institute of Scientific and Technical Information of China (English)

    Priti Singh; Shailendra Kumar Pandey; Jyoti Singh; Sameer Srivastava; Sadhana Sachan; Sunil Kumar Singh

    2016-01-01

    Electrochemical biosensor holds great promise in the biomedical area due to its enhanced specificity, sensi-tivity, label-free nature and cost effectiveness for rapid point-of-care detection of diseases at bedside. In this review, we are focusing on the working principle of electrochemical biosensor and how it can be employed in detecting biomarkers of fatal diseases like cancer, AIDS, hepatitis and cardiovascular diseases. Recent advances in the development of implantable biosensors and exploration of nanomaterials in fabrication of electrodes with increasing the sensitivity of biosensor for quick and easy detection of biomolecules have been elucidated in detail. Electrochemical-based detection of heavy metal ions which cause harmful effect on human health has been discussed. Key challenges associated with the electrochemical sensor and its future perspectives are also addressed.

  1. Tritium AMS for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, M.L.; Velsko, C.; Turteltaub, K.W.

    1993-08-01

    We are developing {sup 3}H-AMS to measure {sup 3}H activity of mg-sized biological samples. LLNL has already successfully applied {sup 14}C AMS to a variety of problems in the area of biomedical research. Development of {sup 3}H AMS would greatly complement these studies. The ability to perform {sup 3}H AMS measurements at sensitivities equivalent to those obtained for {sup 14}C will allow us to perform experiments using compounds that are not readily available in {sup 14}C-tagged form. A {sup 3}H capability would also allow us to perform unique double-labeling experiments in which we learn the fate, distribution, and metabolism of separate fractions of biological compounds.

  2. Biomedical Applications for Introductory Physics

    Science.gov (United States)

    Tuszynski, J. A.; Dixon, J. M.

    2001-12-01

    Can be utilized in either Algebra or Calculus-based courses and is available either as a standalone text or as a supplement for books like Cutnell PHYSICS, 5e or Halliday, Resnick, & Walker FUNDAMENTALS OF PHYSICS, 6e. Math level is Algebra & Trigonometry; however, a few examples require the use of integration and differentiation. Unlike competing supplements, Tuszinski offers both a wealth of engaging biomedical applications as well as quantitative problem-solving. The quantitative problem-solving is presented in the form of worked examples and homework problems. The quantitative problem-solving is presented in the form of worked examples and homework problems. The standard organization facilitates the integration of the material into most introductory courses.

  3. Biomedical Wireless Ambulatory Crew Monitor

    Science.gov (United States)

    Chmiel, Alan; Humphreys, Brad

    2009-01-01

    A compact, ambulatory biometric data acquisition system has been developed for space and commercial terrestrial use. BioWATCH (Bio medical Wireless and Ambulatory Telemetry for Crew Health) acquires signals from biomedical sensors using acquisition modules attached to a common data and power bus. Several slots allow the user to configure the unit by inserting sensor-specific modules. The data are then sent real-time from the unit over any commercially implemented wireless network including 802.11b/g, WCDMA, 3G. This system has a distributed computing hierarchy and has a common data controller on each sensor module. This allows for the modularity of the device along with the tailored ability to control the cards using a relatively small master processor. The distributed nature of this system affords the modularity, size, and power consumption that betters the current state of the art in medical ambulatory data acquisition. A new company was created to market this technology.

  4. Cell mechanics in biomedical cavitation

    Science.gov (United States)

    Wang, Qianxi; Manmi, Kawa; Liu, Kuo-Kang

    2015-01-01

    Studies on the deformation behaviours of cellular entities, such as coated microbubbles and liposomes subject to a cavitation flow, become increasingly important for the advancement of ultrasonic imaging and drug delivery. Numerical simulations for bubble dynamics of ultrasound contrast agents based on the boundary integral method are presented in this work. The effects of the encapsulating shell are estimated by adapting Hoff's model used for thin-shell contrast agents. The viscosity effects are estimated by including the normal viscous stress in the boundary condition. In parallel, mechanical models of cell membranes and liposomes as well as state-of-the-art techniques for quantitative measurement of viscoelasticity for a single cell or coated microbubbles are reviewed. The future developments regarding modelling and measurement of the material properties of the cellular entities for cutting-edge biomedical applications are also discussed. PMID:26442142

  5. Science and Technology of Bio-Inert Thin Films as Hermetic-Encapsulating Coatings for Implantable Biomedical Devices: Application to Implantable Microchip in the Eye for the Artificial Retina

    Science.gov (United States)

    Auciello, Orlando; Shi, Bing

    Extensive research has been devoted to the development of neuron prostheses and hybrid bionic systems to establish links between the nervous system and electronic or robotic prostheses with the main focus of restoring motor and sensory functions in blind patients. Artificial retinas, one type of neural prostheses we are currently working on, aim to restore some vision in blind patients caused by retinitis picmentosa or macular degeneration, and in the future to restore vision at the level of face recognition, if not more. Currently there is no hermetic microchip-size coating that provides a reliable, long-term (years) performance as encapsulating coating for the artificial retina Si microchip to be implanted inside the eye. This chapter focuses on the critical topics relevant to the development of a robust, long-term artificial retina device, namely the science and technology of hermetic bio-inert encapsulating coatings to protect a Si microchip implanted in the human eye from being attacked by chemicals existing in the eye's saline environment. The work discussed in this chapter is related to the development of a novel ultrananocrystalline diamond (UNCD) hermetic coating, which exhibited no degradation in rabbit eyes. The material synthesis, characterization, and electrochemical properties of these hermetic coatings are reviewed for application as encapsulating coating for the artificial retinal microchips implantable inside the human eye. Our work has shown that UNCD coatings may provide a reliable hermetic bio-inert coating technology for encapsulation of Si microchips implantable in the eye specifically and in the human body in general. Electrochemical tests of the UNCD films grown under CH4/Ar/H2 (1%) plasma exhibit the lowest leakage currents (˜7 × 10-7 A/cm2) in a saline solution simulating the eye environment. This leakage is incompatible with the functionality of the first-generation artificial retinal microchip. However, the growth of UNCD on top of the

  6. Building biomedical web communities using a semantically aware content management system.

    Science.gov (United States)

    Das, Sudeshna; Girard, Lisa; Green, Tom; Weitzman, Louis; Lewis-Bowen, Alister; Clark, Tim

    2009-03-01

    Web-based biomedical communities are becoming an increasingly popular vehicle for sharing information amongst researchers and are fast gaining an online presence. However, information organization and exchange in such communities is usually unstructured, rendering interoperability between communities difficult. Furthermore, specialized software to create such communities at low cost-targeted at the specific common information requirements of biomedical researchers-has been largely lacking. At the same time, a growing number of biological knowledge bases and biomedical resources are being structured for the Semantic Web. Several groups are creating reference ontologies for the biomedical domain, actively publishing controlled vocabularies and making data available in Resource Description Framework (RDF) language. We have developed the Science Collaboration Framework (SCF) as a reusable platform for advanced structured online collaboration in biomedical research that leverages these ontologies and RDF resources. SCF supports structured 'Web 2.0' style community discourse amongst researchers, makes heterogeneous data resources available to the collaborating scientist, captures the semantics of the relationship among the resources and structures discourse around the resources. The first instance of the SCF framework is being used to create an open-access online community for stem cell research-StemBook (http://www.stembook.org). We believe that such a framework is required to achieve optimal productivity and leveraging of resources in interdisciplinary scientific research. We expect it to be particularly beneficial in highly interdisciplinary areas, such as neurodegenerative disease and neurorepair research, as well as having broad utility across the natural sciences.

  7. From GRID to gridlock: the relationship between scientific biomedical breakthroughs and HIV/AIDS policy in the US Congress

    Directory of Open Access Journals (Sweden)

    Matthew B Platt

    2013-11-01

    Full Text Available Introduction: From the travel ban on people living with HIV (PLHIV to resistance to needle exchange programmes, there are many examples where policy responses to HIV/AIDS in the United States seem divorced from behavioural, public health and sociological evidence. At its root, however, the unknowns about HIV/AIDS lie at biomedical science, and scientific researchers have made tremendous progress over the past 30 years of the epidemic by using antiretroviral therapy to increase the life expectancy of PLHIV almost to the same level as non-infected individuals; but a relationship between biomedical science discoveries and congressional responses to HIV/AIDS has not been studied. Using quantitative approaches, we directly examine the hypothesis that progress in HIV/AIDS biomedical science discoveries would have a correlative relationship with congressional response to HIV/AIDS from 1981 to 2010. Methods: This study used original data on every bill introduced, hearing held and law passed by the US Congress relating to HIV/AIDS over 30 years (1981–2010. We combined congressional data with the most cited and impactful biomedical research scientific publications over the same time period as a metric of biomedical science breakthroughs. Correlations between congressional policy and biomedical research were then analyzed at the aggregate and individual levels. Results: Biomedical research advancements helped shape both the level and content of bill sponsorship on HIV/AIDS, but they had no effect on other stages of the legislative process. Examination of the content of bills and biomedical research indicated that science helped transform HIV/AIDS bill sponsorship from a niche concern of liberal Democrats to a bipartisan coalition when Republicans became the majority party. The trade-off for that expansion has been an emphasis on the global epidemic to the detriment of domestic policies and programmes. Conclusions: Breakthroughs in biomedical science did

  8. Focus on polymer chemistry papers in Science in China Series B:Chemistry of the year 2009

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The journal Science in China Series B:Chemistry published 11 and 37 papers in polymer fields in 2008 and 2009,respectively,leading to a percentage increase of 236% and thereby a great historic breakthrough of the journal.These papers mainly focus on three fields:(1) polymer synthesis,(2) functional polymer materials and (3) biomedical polymers.Several research groups published a series of papers in Science in China Series B:Chemistry and detailedly introduced their works in the related fields.

  9. Education of biomedical engineering in Taiwan.

    Science.gov (United States)

    Lin, Kang-Ping; Kao, Tsair; Wang, Jia-Jung; Chen, Mei-Jung; Su, Fong-Chin

    2014-01-01

    Biomedical Engineers (BME) play an important role in medical and healthcare society. Well educational programs are important to support the healthcare systems including hospitals, long term care organizations, manufacture industries of medical devices/instrumentations/systems, and sales/services companies of medical devices/instrumentations/system. In past 30 more years, biomedical engineering society has accumulated thousands people hold a biomedical engineering degree, and work as a biomedical engineer in Taiwan. Most of BME students can be trained in biomedical engineering departments with at least one of specialties in bioelectronics, bio-information, biomaterials or biomechanics. Students are required to have internship trainings in related institutions out of campus for 320 hours before graduating. Almost all the biomedical engineering departments are certified by IEET (Institute of Engineering Education Taiwan), and met the IEET requirement in which required mathematics and fundamental engineering courses. For BMEs after graduation, Taiwanese Society of Biomedical Engineering (TSBME) provides many continue-learning programs and certificates for all members who expect to hold the certification as a professional credit in his working place. In current status, many engineering departments in university are continuously asked to provide joint programs with BME department to train much better quality students. BME is one of growing fields in Taiwan.

  10. From global bioethics to ethical governance of biomedical research collaborations

    DEFF Research Database (Denmark)

    Wahlberg, Ayo; Rehmann-Sutter, Christoph; Sleeboom-Faulkner, Margaret

    2013-01-01

    standardisation under the rubric of ‘global bioethics’. Such a ‘global’, ‘Western’ or ‘universal’ bioethics has in turn been critiqued as an imposition upon resource-poor, non-Western or local medical settings. In this article, we propose that a different tack is necessary if we are to come to grips......One of the features of advanced life sciences research in recent years has been its internationalisation, with countries such as China and South Korea considered ‘emerging biotech’ locations. As a result, crosscontinental collaborations are becoming common generating moves towards ethical and legal...... with the ethical challenges that inter-continental biomedical research collaborations generate. In particular we ask how national systems of ethical governance of life science research might cope with increasingly global research collaborations with a focus on Sino-European collaboration. We propose four ‘spheres...

  11. Towards a broader understanding of agency in biomedical ethics.

    Science.gov (United States)

    López Barreda, Rodrigo; Trachsel, Manuel; Biller-Andorno, Nikola

    2016-09-01

    With advances in medical science, the concept of agency has received increasing attention in biomedical ethics. However, most of the ethical discussion around definitions of agency has focused either on patients suffering from mental disorders or on patients receiving cutting-edge medical treatments in developed countries. Very little of the discussion around concepts of agency has focused on the situation of patients suffering from common diseases that affect populations worldwide. Therefore, the most widely-used definitions of agency may be not appropriate to analyse common diseases among large populations. The branch of social sciences known as development studies draw on their own definitions of the term agency that may provide a more applicable and accurate way of referring to common and general cases than the definitions currently used in bioethics. Moreover, the psychological Self-Determination Theory may improve the usefulness of these definitions in common situations. This article explains the characteristics and the shortcomings of current bioethical definitions of agency when they are applied to common medical conditions worldwide. A new, value-based concept of agency, informed by development studies, is proposed as more accurate and useful for biomedical ethics.

  12. The educational value of teaching biomedical engineering history.

    Science.gov (United States)

    Requena-Carrion, Jesus; Leder, Ron S; Beebe, M; Geselowitz, M

    2010-01-01

    It has been previously argued that science and engineering undergraduate students can benefit greatly from learning the history of their discipline. In order to successfully enhance learning by introducing history into undergraduate curriculum, it would be desirable to assess what the current educational uses of history are and to understand the needs and perceptions of teachers. Nevertheless, to our knowledge no quantitative study of the role of the history of science, engineering, and technology in the classroom has been so far conducted. In this paper we present the design of a survey aimed at assessing the current perception of teachers towards using the history of biomedical engineering (HBME) to enhance learning. This survey was part of a broader project originally led by the EMBS History Committee aimed at evaluating the educational value of the HBME, both for future biomedical engineers and for the broader public. The main goals of the survey are (1) to find out the current uses of the HBME in the classroom, and (2) to identify possible obstacles to expanding the HBME in the classroom.

  13. Lead Test

    Science.gov (United States)

    ... months, and at 3, 4, 5, and 6 years of age. A blood lead level test should be done only if the risk ... recommended if the person is symptomatic at any level below 70 mcg/dL. Because lead will pass through the blood to an unborn child, pregnant ...

  14. The fully integrated biomedical engineering programme at Eindhoven University of Technology.

    Science.gov (United States)

    Slaaf, D W; van Genderen, M H P

    2009-05-01

    The development of a fully integrated biomedical engineering programme (life sciences included from the start) is described. Details are provided about background, implementation, and didactic concept: design centred learning combined with courses. The curriculum has developed into a bachelor-master's programme with two different master's degrees: Master's Degree in Biomedical Engineering and Master's Degree in Medical Engineering. Recently, the programme has adopted semester programming, has included a major and minor in the bachelor's degree phase, and a true bachelor's degree final project. Details about the programme and data about where graduates find jobs are provided in this paper.

  15. Governance of biomedical research in Singapore and the challenge of conflicts of interest.

    Science.gov (United States)

    Ho, Calvin Wai Loon; De Castro, Leonardo D; Campbell, Alastair V

    2014-07-01

    This article discusses the establishment of a governance framework for biomedical research in Singapore. It focuses on the work of the Bioethics Advisory Committee (BAC), which has been instrumental in institutionalizing a governance framework, through the provision of recommendations to the government, and through the coordination of efforts among government agencies. However, developing capabilities in biomedical sciences presents challenges that are qualitatively different from those of past technologies. The state has a greater role to play in balancing conflicting and potentially irreconcilable economic, social, and political goals. This article analyzes the various ways by which the BAC has facilitated this.

  16. Veterans administration biomedical engineer training program.

    Science.gov (United States)

    Bradley, D E

    1981-01-01

    The Veterans administration's Department of Medical and Surgery includes in its Graduate Engineer Training Program a special program for Biomedical Engineers. The program is intended for recent graduates in biomedical engineering and provides for the VA a means of recruiting and training biomedical engineers for employment in its medical centers nationwide. This paper discusses the structure and objectives of the program, the opportunities that exist for the trainee within the program and the results of the program since its inception in 1973, and provides an outlook on the future of the program.

  17. Translational Bioinformatics and Clinical Research (Biomedical) Informatics.

    Science.gov (United States)

    Sirintrapun, S Joseph; Zehir, Ahmet; Syed, Aijazuddin; Gao, JianJiong; Schultz, Nikolaus; Cheng, Donavan T

    2016-03-01

    Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations.

  18. Enhancing biomedical design with design thinking.

    Science.gov (United States)

    Kemnitzer, Ronald; Dorsa, Ed

    2009-01-01

    The development of biomedical equipment is justifiably focused on making products that "work." However, this approach leaves many of the people affected by these designs (operators, patients, etc.) with little or no representation when it comes to the design of these products. Industrial design is a "user focused" profession which takes into account the needs of diverse groups when making design decisions. The authors propose that biomedical equipment design can be enhanced, made more user and patient "friendly" by adopting the industrial design approach to researching, analyzing, and ultimately designing biomedical products.

  19. Recent developments in intelligent biomedical polymers

    Institute of Scientific and Technical Information of China (English)

    XIAO ChunSheng; TIAN HuaYu; ZHUANG XiuLi; CHEN XueSi; JING XiaBin

    2009-01-01

    Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique 'intelligent' characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented.

  20. Biomedical Optical Imaging Technologies Design and Applications

    CERN Document Server

    2013-01-01

    This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.