WorldWideScience

Sample records for biomedical complex systems

  1. Trends in modeling Biomedical Complex Systems

    OpenAIRE

    Remondini Daniel; Castellani Gastone; Romano Paolo; Milanesi Luciano; Liò Petro

    2009-01-01

    Abstract In this paper we provide an introduction to the techniques for multi-scale complex biological systems, from the single bio-molecule to the cell, combining theoretical modeling, experiments, informatics tools and technologies suitable for biological and biomedical research, which are becoming increasingly multidisciplinary, multidimensional and information-driven. The most important concepts on mathematical modeling methodologies and statistical inference, bioinformatics and standards...

  2. Complex biomedical systems: from basic science to translation.

    Science.gov (United States)

    Grzywacz, Norberto M

    2012-07-01

    The Department of Biomedical Engineering (BME) of the University of Southern California (BME@USC) has a longstanding tradition of advancing biomedicine through the development and application of novel engineering ideas. More than 80 primary and affiliated faculty members conduct cutting-edge research in a wide variety of areas, such as neuroengineering, biosystems and biosignal analysis, medical devices (including biomicroelectromechanical systems (bioMEMS) and bionanotechnology), biomechanics, bioimaging, and imaging informatics. Currently, the department hosts six internationally recognized research centers: the Biomimetic MicroElectronic Systems Engineering Research Center (funded by the National Science Foundation), the Biomedical Simulations Resource [funded by the National Institutes of Health (NIH)], the Medical Ultrasonic Transducer Center (funded by NIH), the Center for Neural Engineering, the Center for Vision Science and Technology (funded by an NIH Bioengineering Research Partnership Grant), and the Center for Genomic and Phenomic Studies in Autism (funded by NIH). BME@USC ranks in the top tier of all U.S. BME departments in terms of research funding per faculty. PMID:22850833

  3. Biomedical signals and systems

    CERN Document Server

    Tranquillo, Joseph V

    2013-01-01

    Biomedical Signals and Systems is meant to accompany a one-semester undergraduate signals and systems course. It may also serve as a quick-start for graduate students or faculty interested in how signals and systems techniques can be applied to living systems. The biological nature of the examples allows for systems thinking to be applied to electrical, mechanical, fluid, chemical, thermal and even optical systems. Each chapter focuses on a topic from classic signals and systems theory: System block diagrams, mathematical models, transforms, stability, feedback, system response, control, time

  4. Visualization and simulation of complex flows in biomedical engineering

    CERN Document Server

    Imai, Yohsuke; Ishikawa, Takuji; Oliveira, Mónica

    2014-01-01

    This book focuses on the most recent advances in the application of visualization and simulation methods to understand the flow behavior of complex fluids used in biomedical engineering and other related fields. It shows the physiological flow behavior in large arteries, microcirculation, respiratory systems and in biomedical microdevices.

  5. Telemedicine optoelectronic biomedical data processing system

    Science.gov (United States)

    Prosolovska, Vita V.

    2010-08-01

    The telemedicine optoelectronic biomedical data processing system is created to share medical information for the control of health rights and timely and rapid response to crisis. The system includes the main blocks: bioprocessor, analog-digital converter biomedical images, optoelectronic module for image processing, optoelectronic module for parallel recording and storage of biomedical imaging and matrix screen display of biomedical images. Rated temporal characteristics of the blocks defined by a particular triggering optoelectronic couple in analog-digital converters and time imaging for matrix screen. The element base for hardware implementation of the developed matrix screen is integrated optoelectronic couples produced by selective epitaxy.

  6. Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems

    Energy Technology Data Exchange (ETDEWEB)

    Aitken, Jade B.; Carter, Elizabeth A. [School of Chemistry, University of Sydney, NSW 2006 (Australia); Eastgate, Harold [Eastmac Pty Ltd, 8 Cassinia Close, Knoxfield, Vic 3180 (Australia); Hackett, Mark J.; Harris, Hugh H.; Levina, Aviva [School of Chemistry, University of Sydney, NSW 2006 (Australia); Lee, Y.-C.; Chen, C.-I. [National Synchrotron Radiation Research Centre, No. 101 Hsin-Ann Road, Hsinchu 30076, Taiwan (China); Lai, Barry; Vogt, Stefan [X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439 (United States); Lay, Peter A., E-mail: p.lay@chem.usyd.edu.a [School of Chemistry, University of Sydney, NSW 2006 (Australia)

    2010-02-15

    Protein crystallography and NMR spectroscopy took decades to emerge as routine techniques in structural biology. X-ray absorption spectroscopy now has reached a similar stage of maturity for obtaining complementary local structural information around metals in metalloproteins. However, the relatively recent emergence of X-ray and vibrational spectroscopic microprobes that build on these techniques has enabled the structural information obtained from the 'mature' techniques on isolated biomolecules to be translated into in situ structural information from inhomogeneous complex systems, such as whole cells and tissues.

  7. Cardiovascular system simulation in biomedical engineering education.

    Science.gov (United States)

    Rideout, V. C.

    1972-01-01

    Use of complex cardiovascular system models, in conjunction with a large hybrid computer, in biomedical engineering courses. A cardiovascular blood pressure-flow model, driving a compartment model for the study of dye transport, was set up on the computer for use as a laboratory exercise by students who did not have the computer experience or skill to be able to easily set up such a simulation involving some 27 differential equations running at 'real time' rate. The students were given detailed instructions regarding the model, and were then able to study effects such as those due to septal and valve defects upon the pressure, flow, and dye dilution curves. The success of this experiment in the use of involved models in engineering courses was such that it seems that this type of laboratory exercise might be considered for use in physiology courses as an adjunct to animal experiments.

  8. Personalized biomedical devices & systems for healthcare applications

    Science.gov (United States)

    Chen, I.-Ming; Phee, Soo Jay; Luo, Zhiqiang; Lim, Chee Kian

    2011-03-01

    With the advancement in micro- and nanotechnology, electromechanical components and systems are getting smaller and smaller and gradually can be applied to the human as portable, mobile and even wearable devices. Healthcare industry have started to benefit from this technology trend by providing more and more miniature biomedical devices for personalized medical treatments in order to obtain better and more accurate outcome. This article introduces some recent development in non-intrusive and intrusive biomedical devices resulted from the advancement of niche miniature sensors and actuators, namely, wearable biomedical sensors, wearable haptic devices, and ingestible medical capsules. The development of these devices requires carful integration of knowledge and people from many different disciplines like medicine, electronics, mechanics, and design. Furthermore, designing affordable devices and systems to benefit all mankind is a great challenge ahead. The multi-disciplinary nature of the R&D effort in this area provides a new perspective for the future mechanical engineers.

  9. Convergence of Terahertz Sciences in Biomedical Systems

    CERN Document Server

    Kim, Yong; Han, Haewook; Han, Joon; Ahn, Jaewook; Son, Joo-Hiuk; Park, Woong-Yang; Jeong, Young

    2012-01-01

    Recent technological breakthrough in the field of Terahertz radiation has triggered new applications in biology and biomedicine. Particularly, biological applications are based on the specific spectroscopic fingerprints of biological matter in this spectral region. Historically with the discovery of new electromagnetic wave spectrum, we have always discovered new medical diagnostic imaging systems. The use of terahertz wave was not realized due to the absence of useful terahertz sources. Now after successful generation of THz waves, it is reported that a great potential for THz wave exists for its resonance with bio-molecules. There are many challenging issues such as development of THz passive and active instrumentations, understanding of THz-Bio interaction for THz spectroscopy, THz-Bio nonlinear phenomena and safety guideline, and THz imaging systems. Eventually the deeper understanding of THz-Bio interaction and novel THz systems enable us to develop powerful THz biomedical imaging systems which can contr...

  10. A Semantics and Data-Driven Biomedical Multimedia Software System

    Directory of Open Access Journals (Sweden)

    Shih-Hsi Liu

    2010-08-01

    Full Text Available Developing a large-scale biomedical multimedia software system is always a challenging task: Satisfaction of sundry and stringent biomedical multimedia related requirements and standards; Heterogeneous software deployment and communication environments; and tangling correlation between data/contents and software functionalities, among others. This paper introduces a novel biomedical multimedia software system developed under Service-Oriented Architecture (SOA. Such a system takes the advantage of interoperability of SOA to solve the heterogeneity and correlation problems. The paper also classifies the system into services, annotation, ontologies, semantics matching, and QoS optimization aspects which may potentially solve the requirements problem: By establishing data ontology with respect to data properties, contents, QoS, and biomedical regulations and expanding service ontology to describe more functional and QoS specifications supported by services, appropriate services for processing biomedical multimedia data may be discovered, performed, tuned up or replaced as needed. Lastly, a biomedical education project that improves the performance of feature extraction and classification processed afterwards is introduced to illustrate the advantages of our software system developed under SOA.

  11. Enabling Ontology Based Semantic Queries in Biomedical Database Systems.

    Science.gov (United States)

    Zheng, Shuai; Wang, Fusheng; Lu, James; Saltz, Joel

    2012-01-01

    While current biomedical ontology repositories offer primitive query capabilities, it is difficult or cumbersome to support ontology based semantic queries directly in semantically annotated biomedical databases. The problem may be largely attributed to the mismatch between the models of the ontologies and the databases, and the mismatch between the query interfaces of the two systems. To fully realize semantic query capabilities based on ontologies, we develop a system DBOntoLink to provide unified semantic query interfaces by extending database query languages. With DBOntoLink, semantic queries can be directly and naturally specified as extended functions of the database query languages without any programming needed. DBOntoLink is adaptable to different ontologies through customizations and supports major biomedical ontologies hosted at the NCBO BioPortal. We demonstrate the use of DBOntoLink in a real world biomedical database with semantically annotated medical image annotations. PMID:23404054

  12. Cloud Based Metalearning System for Predictive Modeling of Biomedical Data

    Directory of Open Access Journals (Sweden)

    Milan Vukićević

    2014-01-01

    Full Text Available Rapid growth and storage of biomedical data enabled many opportunities for predictive modeling and improvement of healthcare processes. On the other side analysis of such large amounts of data is a difficult and computationally intensive task for most existing data mining algorithms. This problem is addressed by proposing a cloud based system that integrates metalearning framework for ranking and selection of best predictive algorithms for data at hand and open source big data technologies for analysis of biomedical data.

  13. Data Mining Algorithms for Classification of Complex Biomedical Data

    Science.gov (United States)

    Lan, Liang

    2012-01-01

    In my dissertation, I will present my research which contributes to solve the following three open problems from biomedical informatics: (1) Multi-task approaches for microarray classification; (2) Multi-label classification of gene and protein prediction from multi-source biological data; (3) Spatial scan for movement data. In microarray…

  14. Complex Systems

    Directory of Open Access Journals (Sweden)

    Yi Zhao

    2012-01-01

    Full Text Available Quantum instanton (QI approximation is recently proposed for the evaluations of the chemical reaction rate constants with use of full dimensional potential energy surfaces. Its strategy is to use the instanton mechanism and to approximate time-dependent quantum dynamics to the imaginary time propagation of the quantities of partition function. It thus incorporates the properties of the instanton idea and the quantum effect of partition function and can be applied to chemical reactions of complex systems. In this paper, we present the QI approach and its applications to several complex systems mainly done by us. The concrete systems include, (1 the reaction of H+CH4→H2+CH3, (2 the reaction of H+SiH4→H2+SiH3, (3 H diffusion on Ni(100 surface; and (4 surface-subsurface transport and interior migration for H/Ni. Available experimental and other theoretical data are also presented for the purpose of comparison.

  15. Resolving complex research data management issues in biomedical laboratories: Qualitative study of an industry-academia collaboration.

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L; Bova, G Steven; Wang, Jian; Ackerman, Christopher F; Berlinicke, Cynthia A; Chen, Steve H; Lindvall, Mikael; Zack, Donald J

    2016-04-01

    This paper describes a distributed collaborative effort between industry and academia to systematize data management in an academic biomedical laboratory. Heterogeneous and voluminous nature of research data created in biomedical laboratories make information management difficult and research unproductive. One such collaborative effort was evaluated over a period of four years using data collection methods including ethnographic observations, semi-structured interviews, web-based surveys, progress reports, conference call summaries, and face-to-face group discussions. Data were analyzed using qualitative methods of data analysis to (1) characterize specific problems faced by biomedical researchers with traditional information management practices, (2) identify intervention areas to introduce a new research information management system called Labmatrix, and finally to (3) evaluate and delineate important general collaboration (intervention) characteristics that can optimize outcomes of an implementation process in biomedical laboratories. Results emphasize the importance of end user perseverance, human-centric interoperability evaluation, and demonstration of return on investment of effort and time of laboratory members and industry personnel for success of implementation process. In addition, there is an intrinsic learning component associated with the implementation process of an information management system. Technology transfer experience in a complex environment such as the biomedical laboratory can be eased with use of information systems that support human and cognitive interoperability. Such informatics features can also contribute to successful collaboration and hopefully to scientific productivity. PMID:26652980

  16. Biomedical tracers: technetium-99 m complexing sulfur polydentate ligands

    International Nuclear Information System (INIS)

    Cyclic and acyclic tetra sulfur ligands have been synthesized and some of them have been labelled with technetium-99m. These works have two different aims: 1- Development of methods permitting to obtain easily potential technetium complexing sulfur polydentate chelates. 2- Research of positive and neutral complexes of this metal likely to replace thalium-201 in the coronary flow estimation and [TcO-HMPAO] sup 0 complex in the cerebral scintigraphy, respectively. In this work, first, different ways for obtaining dithioetherdithiols and cyclic tetrathioethers containing functional groups have been carried out, then complexation of the core of nitrutechnetium (TcN) sup 2+ at tracers scale, by dithioetherdithiols, using exchange reaction with [sup 9 sup 9 sup m TcNCl sub 4 ] sup - ion complex or sup 99 sup m TcN Cl sub 2 [P(CH sub 2 CH sub 2 CN) sub 3 ] sub 2 has been studied. Finally, biological distribution in swiss mouse of these technetiated complexes has been studied. 135 refs., 30 figs., 13 tabs. (F.M.)

  17. A multi-material virtual prototyping system for biomedical applications

    OpenAIRE

    Choi, SH; Cheung, HH; Zhu, WK

    2009-01-01

    This paper describes a multi-material virtual prototyping (MMVP) system for modelling and digital fabrication of discrete and functionally graded multi-material objects for biomedical applications. The MMVP system consists of a DMMVP module, an FGMVP module, and a virtual reality (VR) simulation module. The DMMVP module is used for design and process planning of discrete multi-material (DMM) objects, while the FGMVP module is for functionally graded multimaterial (FGM) objects. The VR simulat...

  18. Development of a novel microwave hyperthermia system for biomedical applications

    OpenAIRE

    Cañavate Sánchez, María Jesús

    2015-01-01

    [ENG]Microwave technology is now widely used in a variety of medical applications such as cancer treatment and diagnostics. This project describes the structure of a novel hyperthermia system for biomedical research. The software Ansoft HFSS was used to design a rectangular waveguide applicator. A closed-loop is presented in order to control the output power of the system by the temperature measured on the sample. Initial results from experimental testing are presented. In thes...

  19. [Big data, medical language and biomedical terminology systems].

    Science.gov (United States)

    Schulz, Stefan; López-García, Pablo

    2015-08-01

    A variety of rich terminology systems, such as thesauri, classifications, nomenclatures and ontologies support information and knowledge processing in health care and biomedical research. Nevertheless, human language, manifested as individually written texts, persists as the primary carrier of information, in the description of disease courses or treatment episodes in electronic medical records, and in the description of biomedical research in scientific publications. In the context of the discussion about big data in biomedicine, we hypothesize that the abstraction of the individuality of natural language utterances into structured and semantically normalized information facilitates the use of statistical data analytics to distil new knowledge out of textual data from biomedical research and clinical routine. Computerized human language technologies are constantly evolving and are increasingly ready to annotate narratives with codes from biomedical terminology. However, this depends heavily on linguistic and terminological resources. The creation and maintenance of such resources is labor-intensive. Nevertheless, it is sensible to assume that big data methods can be used to support this process. Examples include the learning of hierarchical relationships, the grouping of synonymous terms into concepts and the disambiguation of homonyms. Although clear evidence is still lacking, the combination of natural language technologies, semantic resources, and big data analytics is promising. PMID:26077872

  20. Remote powering and data communication for implanted biomedical systems

    CERN Document Server

    Kilinc, Enver Gurhan; Maloberti, Franco

    2016-01-01

    This book describes new circuits and systems for implantable biomedical applications and explains the design of a batteryless, remotely-powered implantable micro-system, designed for long-term patient monitoring.  Following new trends in implantable biomedical applications, the authors demonstrate a system which is capable of efficient, remote powering and reliable data communication.  Novel architecture and design methodologies are used to transfer power with a low-power, optimized inductive link and data is transmitted by a reliable communication link.  Additionally, an electro-mechanical solution is presented for tracking and monitoring the implantable system, while the patient is mobile.  ·         Describes practical example of an implantable batteryless biomedical system; ·         Analyzes and compares various energy harvesting and power transfer methods; ·         Describes design of remote powering link and data communication of the implantable system, comparing differe...

  1. Biomedical Application of Aerospace Personal Cooling Systems

    Science.gov (United States)

    Ku, Yu-Tsuan E.; Lee, Hank C.; Montgomery, Leslie D.; Webbon, Bruce W.; Kliss, Mark (Technical Monitor)

    1997-01-01

    Personal thermoregulatory systems which are used by astronauts to alleviate thermal stress during extravehicular activity have been applied to the therapeutic management of multiple sclerosis. However, little information is available regarding the physiologic and circulatory changes produced by routine operation of these systems. The objectives of this study were to compare the effectiveness of two passive and two active cooling vests and to measure the body temperature and circulatory changes produced by each cooling vest configuration. The MicroClimate Systems and the Life Enhancement Tech(LET) lightweight liquid cooling vests, the Steele Vest and LET's Zipper Front Garment were used to cool the chest region of 10 male and female subjects (25 to 55 yr.) in this study. Calf, forearm and finger blood flows were measured using a tetrapolar impedance rheograph. The subjects, seated in an upright position at normal room temperature (approx.22C), were tested for 60 min. with the cooling system operated at its maximum cooling capacity. Blood flows were recorded continuously using a computer data acquisition system with a sampling frequency of 250 Hz. Oral, right and left ear temperatures and cooling system parameters were logged manually every 5 min. Arm, leg, chest and rectal temperatures; heart rate; respiration; and an activity index were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. In general, the male and female subjects' oral and ear temperature responses to cooling were similar for all vest configurations tested. Oral temperatures during the recovery period were significantly (Pcooling and recovery periods.

  2. Biomedical Application of Aerospace Personal Cooling Systems

    Science.gov (United States)

    Ku, Yu-Tsuan E.; Lee, Hank C.; Montgomery, Leslie D.; Webbon, Bruce W.; Kliss, Mark (Technical Monitor)

    1997-01-01

    Personal thermoregulatory systems which are used by astronauts to alleviate thermal stress during extravehicular activity have been applied to the therapeutic management of multiple sclerosis. However, little information is available regarding the physiologic and circulatory changes produced by routine operation of these systems. The objectives of this study were to compare the effectiveness of two passive and two active cooling vests and to measure the body temperature and circulatory changes produced by each cooling vest configuration. The MicroClimate Systems and the Life Enhancement Tech(LET) lightweight liquid cooling vests, the Steele Vest and LET's Zipper Front Garment were used to cool the chest region of 10 male and female subjects (25 to 55 yr.) in this study. Calf, forearm and finger blood flows were measured using a tetrapolar impedance rheograph. The subjects, seated in an upright position at normal room temperature (approx.22C), were tested for 60 min. with the cooling system operated at its maximum cooling capacity. Blood flows were recorded continuously using a computer data acquisition system with a sampling frequency of 250 Hz. Oral, right and left ear temperatures and cooling system parameters were logged manually every 5 min. Arm, leg, chest and rectal temperatures; heart rate; respiration; and an activity index were recorded continuously on a U.F.I., Inc. Biolog ambulatory monitor. In general, the male and female subjects' oral and ear temperature responses to cooling were similar for all vest configurations tested. Oral temperatures during the recovery period were significantly (P<0.05) lower than during the control period, approx. 0.2 - 0.5C, for both men and women wearing any of the four different garments. The corresponding ear temperatures were significantly (P<0.05) decreased approx.0.2 - 0.4C by the end of the recovery period. Compared to the control period, no significant differences were found in rectal temperatures during cooling and

  3. Power optimization in wearable biomedical systems: a signal processing perspective

    Science.gov (United States)

    Ghasemzadeh, Hassan

    2012-10-01

    Wearable monitoring systems have caught considerable attention recently due to their potential in many domains including smart health and well-being. These new biomedical monitoring systems aim to provide continuous patient monitoring and proactive care options. Realization of this vision requires research that addresses a number of challenges, in particular, regarding limited resources that the wearable sensor networks offer. This paper presents an overview of different strategies for prolonging system lifetimes through power optimization in such systems. Particular emphasis is given to enhancing processing and communication architectures with respect to the signal processing requirements of the system.

  4. Cloud Based Metalearning System for Predictive Modeling of Biomedical Data

    OpenAIRE

    2014-01-01

    Rapid growth and storage of biomedical data enabled many opportunities for predictive modeling and improvement of healthcare processes. On the other side analysis of such large amounts of data is a difficult and computationally intensive task for most existing data mining algorithms. This problem is addressed by proposing a cloud based system that integrates metalearning framework for ranking and selection of best predictive algorithms for data at hand and open source big data technologies fo...

  5. Collaborative Initiative in Biomedical Imaging to Study Complex Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Weili [The University of North Carolina at Chapel Hill; Fiddy, Michael A. [The University of North Carolina at Charlotte

    2012-03-31

    The work reported addressed these topics: Fluorescence imaging; Optical coherence tomography; X-ray interferometer/phase imaging system; Quantitative imaging from scattered fields, Terahertz imaging and spectroscopy; and Multiphoton and Raman microscopy.

  6. SimplevisGrid: grid services for visualization of diverse biomedical knowledge and molecular systems data.

    Science.gov (United States)

    Stokes, Todd H; Wang, May D

    2009-01-01

    Biomedical data visualization is a great challenge due to the scale, complexity, and diversity of systems, system component interactions and experimental data. Standards for interoperable data are a good start to addressing these problems, but standardization of visualization technologies is an emerging topic. SimpleVisGrid builds on Cancer Biomedical Informatics Grid (caBIG) common infrastructure for cancer research, and clearly specifies and extends three standard data formats for inputs and outputs to grid services: comma-separated values (CSV), Portable Network Graphics (PNG), and Scalable Vector Graphics (SVG). Four prototype visualizations are available: 2D array data quality visualization, correlation heatmaps between high-dimensional data and associated meta-data, feature landscapes, and biochemical or semantic network graphs. The services and data model are prepared for submission for caBIG Silver-level compatibility review and for integration into automated research workflows. Making these tools available to caBIG developers and ultimately to biomedical researchers can (1) help with biomedical communication, discovery, and decision-making, (2) encourage more research on standardization of visualization formats, and (3) improve the efficiency of large data transfers across the grid. PMID:19964624

  7. Using Interactive 3D PDF for Exploring Complex Biomedical Data: Experiences and Solutions.

    Science.gov (United States)

    Newe, Axel; Becker, Linda

    2016-01-01

    The Portable Document Format (PDF) is the most commonly used file format for the exchange of electronic documents. A lesser-known feature of PDF is the possibility to embed three-dimensional models and to display these models interactively with a qualified reader. This technology is well suited to present, to explore and to communicate complex biomedical data. This applies in particular for data which would suffer from a loss of information if it was reduced to a static two-dimensional projection. In this article, we present applications of 3D PDF for selected scholarly and clinical use cases in the biomedical domain. Furthermore, we present a sophisticated tool for the generation of respective PDF documents. PMID:27577484

  8. Biomedical image and signal de-noising using dual tree complex wavelet transform

    Science.gov (United States)

    Rizi, F. Yousefi; Noubari, H. Ahmadi; Setarehdan, S. K.

    2011-10-01

    Dual tree complex wavelet transform(DTCWT) is a form of discrete wavelet transform, which generates complex coefficients by using a dual tree of wavelet filters to obtain their real and imaginary parts. The purposes of de-noising are reducing noise level and improving signal to noise ratio (SNR) without distorting the signal or image. This paper proposes a method for removing white Gaussian noise from ECG signals and biomedical images. The discrete wavelet transform (DWT) is very valuable in a large scope of de-noising problems. However, it has limitations such as oscillations of the coefficients at a singularity, lack of directional selectivity in higher dimensions, aliasing and consequent shift variance. The complex wavelet transform CWT strategy that we focus on in this paper is Kingsbury's and Selesnick's dual tree CWT (DTCWT) which outperforms the critically decimated DWT in a range of applications, such as de-noising. Each complex wavelet is oriented along one of six possible directions, and the magnitude of each complex wavelet has a smooth bell-shape. In the final part of this paper, we present biomedical image and signal de-noising by the means of thresholding magnitude of the wavelet coefficients.

  9. Biomedical indexing and retrieval system based on language modeling approach

    Directory of Open Access Journals (Sweden)

    Jihen Majdoubi

    2012-06-01

    Full Text Available In the medical field, scientific articles represent a very important source of knowledge for researchers of this domain. But due to the large volume of scientific articles published on the web, an efficient detection and use of this knowledge is quite a difficult task. In this paper, we propose our contribution for conceptual indexing of medical articles by using the MeSH (Medical Subject Headings thesaurus. With this in mind, we propose a tool for indexing medical articles called BIOINSY (BIOmedical Indexing SYstem which uses a language model for selecting the best representative descriptors for each document. The proposed indexing approach was evaluated by intensive experiments. These experiments were conducted on document test collections of real world clinical extracted from scientific collections, namely PUBMED and CLEF. The results generated by these experiments demonstrate the effectiveness of our indexing approach.

  10. Arnoldi preconditioning for solving large linear biomedical systems.

    Science.gov (United States)

    Deo, Makarand; Vigmond, Edward

    2005-01-01

    Simulations of biomedical systems often involve solving large, sparse, linear systems of the form Ax = b. In initial value problems, this system is solved at every time step, so a quick solution is essential for tractability. Iterative solvers, especially preconditioned conjugate gradient, are attractive since memory demands are minimized compared to direct methods, albeit at a cost of solution speed. A proper preconditioner can drastically reduce computation and remains an area of active research. In this paper, we propose a novel preconditioner based on system order reduction using the Arnoldi method. Systems of orders up to a million, generated from a finite element method formulation of the elliptic portion of the bidomain equations, are solved with the new preconditioner and performance is compared with that of other preconditioners. Results indicate that the new method converges considerably faster, often within a single iteration. It also uses less memory than an incomplete LU decomposition (ILU). For solving a system repeatedly, the Arnoldi transformation must be continually recomputed, unlike ILU, but this can be done quickly. In conclusion, for solving a system once, the Arnoldi preconditioner offers a greatly reduced solution time, and for repeated solves, will still be faster than an ILU preconditioner. PMID:17282853

  11. Wearable and Implantable Mechanical Energy Harvesters for Self-Powered Biomedical Systems.

    Science.gov (United States)

    Hinchet, Ronan; Kim, Sang-Woo

    2015-08-25

    In this issue of ACS Nano, Tang et al. investigate the ability of a triboelectric nanogenerator (TENG) to self-power a low-level laser cure system for osteogenesis by studying the efficiency of a bone remodeling laser treatment that is powered by a skin-patch-like TENG instead of a battery. We outline this field by highlighting the motivations for self-powered biomedical systems and by discussing recent progress in nanogenerators. We note the overlap between biomedical devices and TENGs and their dawning synergy, and we highlight key prospects for future developments. Biomedical systems should be more autonomous. This advance could improve their body integration and fields of action, leading to new medical diagnostics and treatments. However, future self-powered biomedical systems will need to be more flexible, biocompatible, and biodegradable. These advances hold the promise of enabling new smart autonomous biomedical systems and contributing significantly to the Internet of Things. PMID:26280752

  12. SYSTEMS WITH COMPLEXITY

    Institute of Scientific and Technical Information of China (English)

    WANG Chenghong; ZHANG Lijun

    2004-01-01

    Science of Complexity is a newly emerging branch of natural scienceAlthoughwe still haven't a precise definition, there are some principles for justifying whether a systemis a complex systemThe purpose of this article is to reveal some of such principlesOnthe basis of them, the concept of a system with complexity is proposedThey may helpus to distinguish a real complex system from complicated objects in common senseThenwe propose some fundamental problems faced by the study of systems with complexity.

  13. Fluorescence Resonance Energy Transfer (FRET) systems for biomedical sensor applications

    OpenAIRE

    Bird , Aoibheann

    2010-01-01

    This thesis investigates the use of Fluorescence Resonance Energy Transfer (FRET) for biomedical sensor applications. FRET is a process by which energy is transferred, via long range dipole-dipole interactions, from a donor molecule (D) in an excited electronic state to an acceptor molecule (A). The emission band of D must overlap the absorption band of A in order for FRET to occur. FRET is employed in a variety of biomedical applications, including the study of cell biology an...

  14. Complex Systems and Dependability

    CERN Document Server

    Zamojski, Wojciech; Sugier, Jaroslaw

    2012-01-01

    Typical contemporary complex system is a multifaceted amalgamation of technical, information, organization, software and human (users, administrators and management) resources. Complexity of such a system comes not only from its involved technical and organizational structure but mainly from complexity of information processes that must be implemented in the operational environment (data processing, monitoring, management, etc.). In such case traditional methods of reliability analysis focused mainly on technical level are usually insufficient in performance evaluation and more innovative meth

  15. Injection Molding of Titanium Alloy Implant For Biomedical Application Using Novel Binder System Based on Palm Oil Derivatives

    OpenAIRE

    Ibrahim, R.; M. Azmirruddin; Jabir, M; Ismail, M. R.; M. Muhamad; R. Awang; Muhamad, S.

    2010-01-01

    Problem statement: Titanium alloy (Ti6Al4V) has been widely used as an implant for biomedical application. In this study, the implant had been fabricated using high technology of Powder Injection Molding (PIM) process due to the cost effective technique for producing small, complex and precision parts in high volume compared with conventional method through machining. Approach: Through PIM, the binder system is one of the most important criteria in order to successfully fabricate the implants...

  16. From the NIH: A Systems Approach to Increasing the Diversity of the Biomedical Research Workforce.

    Science.gov (United States)

    Valantine, Hannah A; Lund, P Kay; Gammie, Alison E

    2016-01-01

    The National Institutes of Health (NIH) is committed to attracting, developing, and supporting the best scientists from all groups as an integral part of excellence in training. Biomedical research workforce diversity, capitalizing on the full spectrum of skills, talents, and viewpoints, is essential for solving complex human health challenges. Over the past few decades, the biomedical research workforce has benefited from NIH programs aimed at enhancing diversity. However, there is considerable room for improvement, particularly at the level of independent scientists and within scientific leadership. We provide a rationale and specific opportunities to develop and sustain a diverse biomedical research workforce through interventions that promote the successful transitions to different stages on the path toward completion of training and entry into the biomedical workforce. PMID:27587850

  17. BIG: a Grid Portal for Biomedical Data and Images

    Directory of Open Access Journals (Sweden)

    Giovanni Aloisio

    2004-06-01

    Full Text Available Modern management of biomedical systems involves the use of many distributed resources, such as high performance computational resources to analyze biomedical data, mass storage systems to store them, medical instruments (microscopes, tomographs, etc., advanced visualization and rendering tools. Grids offer the computational power, security and availability needed by such novel applications. This paper presents BIG (Biomedical Imaging Grid, a Web-based Grid portal for management of biomedical information (data and images in a distributed environment. BIG is an interactive environment that deals with complex user's requests, regarding the acquisition of biomedical data, the "processing" and "delivering" of biomedical images, using the power and security of Computational Grids.

  18. Topics in complex systems

    OpenAIRE

    Yap, Yee Jiun

    2006-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. Fundamental laws of physics, although successful in explaining many phenomena observed in nature and society, cannot account for the behaviour of complex, non-Hamiltonian systems. Much effort has been devoted to better understanding the topological properties of these systems. Neither ordered nor disordered, these systems of high variability are found in many areas of science. Studies on sand...

  19. Philosophy of complex systems

    CERN Document Server

    2011-01-01

    The domain of nonlinear dynamical systems and its mathematical underpinnings has been developing exponentially for a century, the last 35 years seeing an outpouring of new ideas and applications and a concomitant confluence with ideas of complex systems and their applications from irreversible thermodynamics. A few examples are in meteorology, ecological dynamics, and social and economic dynamics. These new ideas have profound implications for our understanding and practice in domains involving complexity, predictability and determinism, equilibrium, control, planning, individuality, responsibility and so on. Our intention is to draw together in this volume, we believe for the first time, a comprehensive picture of the manifold philosophically interesting impacts of recent developments in understanding nonlinear systems and the unique aspects of their complexity. The book will focus specifically on the philosophical concepts, principles, judgments and problems distinctly raised by work in the domain of comple...

  20. Modeling Complex Systems

    CERN Document Server

    Boccara, Nino

    2010-01-01

    Modeling Complex Systems, 2nd Edition, explores the process of modeling complex systems, providing examples from such diverse fields as ecology, epidemiology, sociology, seismology, and economics. It illustrates how models of complex systems are built and provides indispensable mathematical tools for studying their dynamics. This vital introductory text is useful for advanced undergraduate students in various scientific disciplines, and serves as an important reference book for graduate students and young researchers. This enhanced second edition includes: . -recent research results and bibliographic references -extra footnotes which provide biographical information on cited scientists who have made significant contributions to the field -new and improved worked-out examples to aid a student’s comprehension of the content -exercises to challenge the reader and complement the material Nino Boccara is also the author of Essentials of Mathematica: With Applications to Mathematics and Physics (Springer, 2007).

  1. Biomedical engineering and nanotechnology

    International Nuclear Information System (INIS)

    This book is predominantly a compilation of papers presented in the conference which is focused on the development in biomedical materials, biomedical devises and instrumentation, biomedical effects of electromagnetic radiation, electrotherapy, radiotherapy, biosensors, biotechnology, bioengineering, tissue engineering, clinical engineering and surgical planning, medical imaging, hospital system management, biomedical education, biomedical industry and society, bioinformatics, structured nanomaterial for biomedical application, nano-composites, nano-medicine, synthesis of nanomaterial, nano science and technology development. The papers presented herein contain the scientific substance to suffice the academic directivity of the researchers from the field of biomedicine, biomedical engineering, material science and nanotechnology. Papers relevant to INIS are indexed separately

  2. Complexity of Economical Systems

    Directory of Open Access Journals (Sweden)

    G. P. Pavlos

    2015-01-01

    Full Text Available In this study new theoretical concepts are described concerning the interpretation of economical complex dynamics. In addition a summary of an extended algorithm of nonlinear time series analysis is provided which is applied not only in economical time series but also in other physical complex systems (e.g. [22, 24]. In general, Economy is a vast and complicated set of arrangements and actions wherein agents—consumers, firms, banks, investors, government agencies—buy and sell, speculate, trade, oversee, bring products into being, offer services, invest in companies, strategize, explore, forecast, compete, learn, innovate, and adapt. As a result the economic and financial variables such as foreign exchange rates, gross domestic product, interest rates, production, stock market prices and unemployment exhibit large-amplitude and aperiodic fluctuations evident in complex systems. Thus, the Economics can be considered as spatially distributed non-equilibrium complex system, for which new theoretical concepts, such as Tsallis non extensive statistical mechanics and strange dynamics, percolation, nonGaussian, multifractal and multiscale dynamics related to fractional Langevin equations can be used for modeling and understanding of the economical complexity locally or globally.

  3. Managing Complex Dynamical Systems

    Science.gov (United States)

    Cox, John C.; Webster, Robert L.; Curry, Jeanie A.; Hammond, Kevin L.

    2011-01-01

    Management commonly engages in a variety of research designed to provide insight into the motivation and relationships of individuals, departments, organizations, etc. This paper demonstrates how the application of concepts associated with the analysis of complex systems applied to such data sets can yield enhanced insights for managerial action.

  4. Control of complex systems

    CERN Document Server

    Albertos, Pedro; Blanke, Mogens; Isidori, Alberto; Schaufelberger, Walter; Sanz, Ricardo

    2001-01-01

    The world of artificial systems is reaching complexity levels that es­ cape human understanding. Surface traffic, electricity distribution, air­ planes, mobile communications, etc. , are examples that demonstrate that we are running into problems that are beyond classical scientific or engi­ neering knowledge. There is an ongoing world-wide effort to understand these systems and develop models that can capture its behavior. The reason for this work is clear, if our lack of understanding deepens, we will lose our capability to control these systems and make they behave as we want. Researchers from many different fields are trying to understand and develop theories for complex man-made systems. This book presents re­ search from the perspective of control and systems theory. The book has grown out of activities in the research program Control of Complex Systems (COSY). The program has been sponsored by the Eu­ ropean Science Foundation (ESF) which for 25 years has been one of the leading players in stimula...

  5. Establishment of an index system for evaluating outstanding biomedical scientists for science foundation of Shanghai

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yu-jing; CHEN Xin; REN Xu-feng

    2007-01-01

    Objective:To establish a scientific, objective and applicable index system for evaluating outstanding biomedical scientists for science foundation of Shanghai. Methods: According to the principal indices that have been used in the developed countries for evaluating their talented personnel and the reality of our country, an index system was set up to evaluate the outstanding biomedical scientists for Shanghai science foundation. The following parameters were used to simplify the indices: correlation coefficient,multiple correlation coefficient, partial correlation coefficient, creditability, and discriminatory power.And analytic hierarchy process was used to determine the weights of each index. Results and Conclusions:The established index system is scientific and applicable; it is helpful for cultivating and evaluating outstanding biomedical scientists.

  6. Question Processing and Clustering in INDOC: A Biomedical Question Answering System

    Directory of Open Access Journals (Sweden)

    Ankush Mittal

    2007-12-01

    Full Text Available The exponential growth in the volume of publications in the biomedical domain has made it impossible for an individual to keep pace with the advances. Even though evidence-based medicine has gained wide acceptance, the physicians are unable to access the relevant information in the required time, leaving most of the questions unanswered. This accentuates the need for fast and accurate biomedical question answering systems. In this paper we introduce INDOC—a biomedical question answering system based on novel ideas of indexing and extracting the answer to the questions posed. INDOC displays the results in clusters to help the user arrive the most relevant set of documents quickly. Evaluation was done against the standard OHSUMED test collection. Our system achieves high accuracy and minimizes user effort.

  7. Question Processing and Clustering in INDOC: A Biomedical Question Answering System

    Directory of Open Access Journals (Sweden)

    Sondhi Parikshit

    2007-01-01

    Full Text Available The exponential growth in the volume of publications in the biomedical domain has made it impossible for an individual to keep pace with the advances. Even though evidence-based medicine has gained wide acceptance, the physicians are unable to access the relevant information in the required time, leaving most of the questions unanswered. This accentuates the need for fast and accurate biomedical question answering systems. In this paper we introduce INDOC—a biomedical question answering system based on novel ideas of indexing and extracting the answer to the questions posed. INDOC displays the results in clusters to help the user arrive the most relevant set of documents quickly. Evaluation was done against the standard OHSUMED test collection. Our system achieves high accuracy and minimizes user effort.

  8. Hardware and software design for a National Instrument-based magnetic induction tomography system for prospective biomedical applications

    International Nuclear Information System (INIS)

    Magnetic induction tomography (MIT) is a new and emerging type of tomography technique that is able to map the passive electromagnetic properties (in particular conductivity) of an object. Excitation coils are used to induce eddy currents in the medium, and the magnetic field produced by the induced eddy current is then sensed by the receiver coils. Because of its non-invasive and contactless feature, it becomes an attractive technique for many applications (especially in biomedical area) compared to traditional contact electrode-based electrical impedance tomography. Due to the low contrast in conductivity between biological tissues, an accurate and stable hardware system is necessary. Most MIT systems in the literature employ external signal generators, power amplifiers and highly stable down-conversion electronics to obtain a satisfactory phase measurement. However, this would increase design complexity substantially. In this paper, a National Instrument-based MIT system is developed at the University of Bath, aiming for biomedical applications. The system utilizes National Instrument products to accomplish all signal driving, switching and data acquisition tasks, which ease the system design whilst providing satisfactory performance. This paper presents a full-scaled medical MIT system, from the sensor and system hardware design, eddy current model verification to the image reconstruction software: the performance of this MIT instrumentation system is characterized in detail, including the system accuracy and system stability. The methods of solving eddy current problem are presented. The reconstructed images of detecting the presence of saline solutions are also included in this paper, which show the capability of national instrument products to be developed into a full-scaled biomedical MIT system, by demonstrating the practical experimental results. (paper)

  9. Hardware and software design for a National Instrument-based magnetic induction tomography system for prospective biomedical applications.

    Science.gov (United States)

    Wei, Hsin-Yu; Soleimani, Manuchehr

    2012-05-01

    Magnetic induction tomography (MIT) is a new and emerging type of tomography technique that is able to map the passive electromagnetic properties (in particular conductivity) of an object. Excitation coils are used to induce eddy currents in the medium, and the magnetic field produced by the induced eddy current is then sensed by the receiver coils. Because of its non-invasive and contactless feature, it becomes an attractive technique for many applications (especially in biomedical area) compared to traditional contact electrode-based electrical impedance tomography. Due to the low contrast in conductivity between biological tissues, an accurate and stable hardware system is necessary. Most MIT systems in the literature employ external signal generators, power amplifiers and highly stable down-conversion electronics to obtain a satisfactory phase measurement. However, this would increase design complexity substantially. In this paper, a National Instrument-based MIT system is developed at the University of Bath, aiming for biomedical applications. The system utilizes National Instrument products to accomplish all signal driving, switching and data acquisition tasks, which ease the system design whilst providing satisfactory performance. This paper presents a full-scaled medical MIT system, from the sensor and system hardware design, eddy current model verification to the image reconstruction software: the performance of this MIT instrumentation system is characterized in detail, including the system accuracy and system stability. The methods of solving eddy current problem are presented. The reconstructed images of detecting the presence of saline solutions are also included in this paper, which show the capability of national instrument products to be developed into a full-scaled biomedical MIT system, by demonstrating the practical experimental results. PMID:22531316

  10. A Computer Based Biomedical Information System. I. Logic Foundation and Techniques

    Science.gov (United States)

    Syner, James C.

    A digital computer based biomedical information system was designed to service the needs of physicians engaged in patient care and clinical research, and scientists engaged in laboratory research. The system embraces all functions of information processing which include information collection, storage, retrieval, analyses and display. The…

  11. Modeling Complex Systems

    International Nuclear Information System (INIS)

    This book by Nino Boccara presents a compilation of model systems commonly termed as 'complex'. It starts with a definition of the systems under consideration and how to build up a model to describe the complex dynamics. The subsequent chapters are devoted to various categories of mean-field type models (differential and recurrence equations, chaos) and of agent-based models (cellular automata, networks and power-law distributions). Each chapter is supplemented by a number of exercises and their solutions. The table of contents looks a little arbitrary but the author took the most prominent model systems investigated over the years (and up until now there has been no unified theory covering the various aspects of complex dynamics). The model systems are explained by looking at a number of applications in various fields. The book is written as a textbook for interested students as well as serving as a comprehensive reference for experts. It is an ideal source for topics to be presented in a lecture on dynamics of complex systems. This is the first book on this 'wide' topic and I have long awaited such a book (in fact I planned to write it myself but this is much better than I could ever have written it!). Only section 6 on cellular automata is a little too limited to the author's point of view and one would have expected more about the famous Domany-Kinzel model (and more accurate citation!). In my opinion this is one of the best textbooks published during the last decade and even experts can learn a lot from it. Hopefully there will be an actualization after, say, five years since this field is growing so quickly. The price is too high for students but this, unfortunately, is the normal case today. Nevertheless I think it will be a great success! (book review)

  12. STUDYING COMPLEX ADAPTIVE SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    John H. Holland

    2006-01-01

    Complex adaptive systems (cas) - systems that involve many components that adapt or learn as they interact - are at the heart of important contemporary problems. The study of cas poses unique challenges: Some of our most powerful mathematical tools, particularly methods involving fixed points, attractors, and the like, are of limited help in understanding the development of cas. This paper suggests ways to modify research methods and tools, with an emphasis on the role of computer-based models, to increase our understanding of cas.

  13. Biomedical Engineering

    CERN Document Server

    Suh, Sang C; Tanik, Murat M

    2011-01-01

    Biomedical Engineering: Health Care Systems, Technology and Techniques is an edited volume with contributions from world experts. It provides readers with unique contributions related to current research and future healthcare systems. Practitioners and researchers focused on computer science, bioinformatics, engineering and medicine will find this book a valuable reference.

  14. Views on the peer review system of biomedical journals: an online survey of academics from high-ranking universities

    OpenAIRE

    Ho, Roger Chun-Man; Mak, Kwok-Kei; Tao, Ren; Lu, Yanxia; Day, Jeffrey R; Pan, Fang

    2013-01-01

    Background Peer review is the major method used by biomedical journals for making the decision of publishing an article. This cross-sectional survey assesses views concerning the review system of biomedical journals among academics globally. Methods A total of 28,009 biomedical academics from high-ranking universities listed by the 2009 Times Higher Education Quacquarelli Symonds (THE-QS) World University Rankings were contacted by email between March 2010 and August 2010. 1,340 completed an ...

  15. Mechanism-based modeling of complex biomedical systems

    DEFF Research Database (Denmark)

    Mosekilde, Erik; Sosnovtseva, Olga; Holstein-Rathlou, N.-H.

    2005-01-01

    Mechanism-based modeling is an approach in which the physiological, pathological and pharmacological processes of relevance to a given problem are represented as directly as possible. This approach allows us (i) to test whether assumed hypotheses are consistent with observed behaviour, (ii) to ex...

  16. An ultra low energy biomedical signal processing system operating at near-threshold

    NARCIS (Netherlands)

    Hulzink, J.; Konijnenburg, M.; Ashouei, M.; Breeschoten, A.; Berset, T.; Huisken, J.; Stuyt, J.; Groot, H. de; Barat, F.; David, J.; Ginderdeuren, J. van

    2011-01-01

    This paper presents a voltage-scalable digital signal processing system designed for the use in a wireless sensor node (WSN) for ambulatory monitoring of biomedical signals. To fulfill the requirements of ambulatory monitoring, power consumption, which directly translates to the WSN battery lifetime

  17. 75 FR 3948 - Big Sky Energy Corp., Biomedical Waste Systems, Inc., Biometrics Security Technology, Inc...

    Science.gov (United States)

    2010-01-25

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Big Sky Energy Corp., Biomedical Waste Systems, Inc., Biometrics Security Technology, Inc., Biosys... Commission that there is a lack of current and accurate information concerning the securities of Big...

  18. Signals and Systems in Biomedical Engineering Signal Processing and Physiological Systems Modeling

    CERN Document Server

    Devasahayam, Suresh R

    2013-01-01

    The use of digital signal processing is ubiquitous in the field of physiology and biomedical engineering. The application of such mathematical and computational tools requires a formal or explicit understanding of physiology. Formal models and analytical techniques are interlinked in physiology as in any other field. This book takes a unitary approach to physiological systems, beginning with signal measurement and acquisition, followed by signal processing, linear systems modelling, and computer simulations. The signal processing techniques range across filtering, spectral analysis and wavelet analysis. Emphasis is placed on fundamental understanding of the concepts as well as solving numerical problems. Graphs and analogies are used extensively to supplement the mathematics. Detailed models of nerve and muscle at the cellular and systemic levels provide examples for the mathematical methods and computer simulations. Several of the models are sufficiently sophisticated to be of value in understanding real wor...

  19. Forecasting in Complex Systems

    Science.gov (United States)

    Rundle, J. B.; Holliday, J. R.; Graves, W. R.; Turcotte, D. L.; Donnellan, A.

    2014-12-01

    Complex nonlinear systems are typically characterized by many degrees of freedom, as well as interactions between the elements. Interesting examples can be found in the areas of earthquakes and finance. In these two systems, fat tails play an important role in the statistical dynamics. For earthquake systems, the Gutenberg-Richter magnitude-frequency is applicable, whereas for daily returns for the securities in the financial markets are known to be characterized by leptokurtotic statistics in which the tails are power law. Very large fluctuations are present in both systems. In earthquake systems, one has the example of great earthquakes such as the M9.1, March 11, 2011 Tohoku event. In financial systems, one has the example of the market crash of October 19, 1987. Both were largely unexpected events that severely impacted the earth and financial systems systemically. Other examples include the M9.3 Andaman earthquake of December 26, 2004, and the Great Recession which began with the fall of Lehman Brothers investment bank on September 12, 2013. Forecasting the occurrence of these damaging events has great societal importance. In recent years, national funding agencies in a variety of countries have emphasized the importance of societal relevance in research, and in particular, the goal of improved forecasting technology. Previous work has shown that both earthquakes and financial crashes can be described by a common Landau-Ginzburg-type free energy model. These metastable systems are characterized by fat tail statistics near the classical spinodal. Correlations in these systems can grow and recede, but do not imply causation, a common source of misunderstanding. In both systems, a common set of techniques can be used to compute the probabilities of future earthquakes or crashes. In this talk, we describe the basic phenomenology of these systems and emphasize their similarities and differences. We also consider the problem of forecast validation and verification

  20. An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

    OpenAIRE

    Seoane, Fernando; Ferreira, Javier; Sanchéz, Juan José; Bragós, Ramon

    2008-01-01

    The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-on-chip fully integrated electrical impedance spectrometer, which might al...

  1. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D

    2014-01-01

    Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardia

  2. Interdisciplinary Symposium on Complex Systems

    CERN Document Server

    Rössler, Otto; Zelinka, Ivan

    2015-01-01

    The book you hold in your hands is the outcome of the “2014 Interdisciplinary Symposium on Complex Systems” held in the historical city of Florence. The book consists of 37 chapters from 4 areas of Physical Modeling of Complex Systems, Evolutionary Computations, Complex Biological Systems and Complex Networks. All 4 parts contain contributions that give interesting point of view on complexity in different areas in science and technology. The book starts with a comprehensive overview and classification of complexity problems entitled Physics in the world of ideas: Complexity as Energy”  , followed by chapters about complexity measures and physical principles, its observation, modeling and its applications, to solving various problems including real-life applications. Further chapters contain recent research about evolution, randomness and complexity, as well as complexity in biological systems and complex networks. All selected papers represent innovative ideas, philosophical overviews and state-of-the-...

  3. Biocompatible hybrid nanomaterials involving polymers and hydrogels interfaced with phosphorescent complexes and toxin-free metallic nanoparticles for biomedical applications

    Science.gov (United States)

    Marpu, Sreekar B.

    The major topics discussed are all relevant to interfacing brightly phosphorescent and non-luminescent coinage metal complexes of [Ag(I) and Au(I)] with biopolymers and thermoresponsive gels for making hybrid nanomaterials with an explanation on syntheses, characterization and their significance in biomedical fields. Experimental results and ongoing work on determining outreaching consequences of these hybrid nanomaterials for various biomedical applications like cancer therapy, bio-imaging and antibacterial abilities are described. In vitro and in vivo studies have been performed on majority of the discussed hybrid nanomaterials and determined that the cytotoxicity or antibacterial activity are comparatively superior when compared to analogues in literature. Consequential differences are noticed in photoluminescence enhancement from hybrid phosphorescent hydrogels, phosphorescent complex ability to physically crosslink, Au(I) sulfides tendency to form NIR (near-infrared) absorbing AuNPs compared to any similar work in literature. Syntheses of these hybrid nanomaterials has been thoroughly investigated and it is determined that either metallic nanoparticles syntheses or syntheses of phosphorescent hydrogels can be carried in single step without involving any hazardous reducing agents or crosslinkers or stabilizers that are commonly employed during multiple step syntheses protocols for syntheses of similar materials in literature. These astounding results that have been discovered within studies of hybrid nanomaterials are an asset to applications ranging from materials development to health science and will have striking effect on environmental and green chemistry approaches.

  4. ON COMPLEX DYNAMIC CONTROL SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    CHENG Daizhan

    2003-01-01

    This paper presents some recent works on the control of dynamic systems, which have certain complex properties caused by singularity of the nonlinear structures, structure-varyings, or evolution process etc. First, we consider the structure singularity of nonlinear control systems. It was revealed that the focus of researches on nonlinear control theory is shifting from regular systems to singular systems. The singularity of nonlinear systems causes certain complexity. Secondly, the switched systems are considered. For such systems the complexity is caused by the structure varying. We show that the switched systems have significant characteristics of complex systems. Finally, we investigate the evolution systems. The evolution structure makes complexity, and itself is a proper model for complex systems.

  5. The Application of Integrated Knowledge-based Systems for the Biomedical Risk Assessment Intelligent Network (BRAIN)

    Science.gov (United States)

    Loftin, Karin C.; Ly, Bebe; Webster, Laurie; Verlander, James; Taylor, Gerald R.; Riley, Gary; Culbert, Chris; Holden, Tina; Rudisill, Marianne

    1993-01-01

    One of NASA's goals for long duration space flight is to maintain acceptable levels of crew health, safety, and performance. One way of meeting this goal is through the Biomedical Risk Assessment Intelligent Network (BRAIN), an integrated network of both human and computer elements. The BRAIN will function as an advisor to flight surgeons by assessing the risk of in-flight biomedical problems and recommending appropriate countermeasures. This paper describes the joint effort among various NASA elements to develop BRAIN and an Infectious Disease Risk Assessment (IDRA) prototype. The implementation of this effort addresses the technological aspects of the following: (1) knowledge acquisition; (2) integration of IDRA components; (3) use of expert systems to automate the biomedical prediction process; (4) development of a user-friendly interface; and (5) integration of the IDRA prototype and Exercise Countermeasures Intelligent System (ExerCISys). Because the C Language, CLIPS (the C Language Integrated Production System), and the X-Window System were portable and easily integrated, they were chosen as the tools for the initial IDRA prototype. The feasibility was tested by developing an IDRA prototype that predicts the individual risk of influenza. The application of knowledge-based systems to risk assessment is of great market value to the medical technology industry.

  6. A remotely powered implantable biomedical system with location detector.

    Science.gov (United States)

    Kilinc, Enver G; Ghanad, Mehrdad A; Maloberti, Franco; Dehollain, Catherine

    2015-02-01

    An universal remote powering and communication system is presented for the implantable medical devices. The system be interfaced with different sensors or actuators. A mobile external unit controls the operation of the implantable chip and reads the sensor's data. A locator system is proposed to align the mobile unit with the implant unit for the efficient magnetic power transfer. The location of the implant is detected with 6 mm resolution from the rectified voltage level at the implanted side. The rectified voltage level is fedback to the mobile unit to adjust the magnetic field strength and maximize the efficiency of the remote powering system. The sensor's data are transmitted by using a free running oscillator modulated with on-off key scheme. To tolerate large data carrier drifts, a custom designed receiver is implemented for the mobile unit. The circuits have been fabricated in 0.18 um CMOS technology. The remote powering link is optimized to deliver power at 13.56 MHz. On chip voltage regulator creates 1.8 V from a 0.9 V reference voltage to supply the sensor/actuator blocks. The implantable chip dissipates 595 μW and requires 1.48 V for start up. PMID:24988596

  7. Impedance matching wireless power transmission system for biomedical devices.

    Science.gov (United States)

    Lum, Kin Yun; Lindén, Maria; Tan, Tian Swee

    2015-01-01

    For medical application, the efficiency and transmission distance of the wireless power transfer (WPT) are always the main concern. Research has been showing that the impedance matching is one of the critical factors for dealing with the problem. However, there is not much work performed taking both the source and load sides into consideration. Both sides matching is crucial in achieving an optimum overall performance, and the present work proposes a circuit model analysis for design and implementation. The proposed technique was validated against experiment and software simulation. Result was showing an improvement in transmission distance up to 6 times, and efficiency at this transmission distance had been improved up to 7 times as compared to the impedance mismatch system. The system had demonstrated a near-constant transfer efficiency for an operating range of 2cm-12cm. PMID:25980873

  8. Biomedical wellness monitoring system based upon molecular markers

    Science.gov (United States)

    Ingram, Whitney

    2012-06-01

    We wish to assist caretakers with a sensor monitoring systems for tracking the physiological changes of homealone patients. One goal is seeking biomarkers and modern imaging sensors like stochastic optical reconstruction microscopy (STORM), which has achieved visible imaging at the nano-scale range. Imaging techniques like STORM can be combined with a fluorescent functional marker in a system to capture the early transformation signs from wellness to illness. By exploiting both microscopic knowledge of genetic pre-disposition and the macroscopic influence of epigenetic factors we hope to target these changes remotely. We adopt dual spectral infrared imaging for blind source separation (BSS) to detect angiogenesis changes and use laser speckle imaging for hypertension blood flow monitoring. Our design hypothesis for the monitoring system is guided by the user-friendly, veteran-preferred "4-Non" principles (noninvasive, non-contact, non-tethered, non-stop-to-measure) and by the NIH's "4Ps" initiatives (predictive, personalized, preemptive, and participatory). We augment the potential storage system with the recent know-how of video Compressive Sampling (CSp) from surveillance cameras. In CSp only major changes are saved, which reduces the manpower cost of caretakers and medical analysts. This CSp algorithm is based on smart associative memory (AM) matrix storage: change features and detailed scenes are written by the outer-product and read by the inner product without the usual Harsh index for image searching. From this approach, we attempt to design an effective household monitoring approach to save healthcare costs and maintain the quality of life of seniors.

  9. Organization of Biomedical Data for Collaborative Scientific Research: A Research Information Management System

    Science.gov (United States)

    Myneni, Sahiti; Patel, Vimla L.

    2010-01-01

    Biomedical researchers often work with massive, detailed and heterogeneous datasets. These datasets raise new challenges of information organization and management for scientific interpretation, as they demand much of the researchers’ time and attention. The current study investigated the nature of the problems that researchers face when dealing with such data. Four major problems identified with existing biomedical scientific information management methods were related to data organization, data sharing, collaboration, and publications. Therefore, there is a compelling need to develop an efficient and user-friendly information management system to handle the biomedical research data. This study evaluated the implementation of an information management system, which was introduced as part of the collaborative research to increase scientific productivity in a research laboratory. Laboratory members seemed to exhibit frustration during the implementation process. However, empirical findings revealed that they gained new knowledge and completed specified tasks while working together with the new system. Hence, researchers are urged to persist and persevere when dealing with any new technology, including an information management system in a research laboratory environment. PMID:20543892

  10. Method for Detecting Core Malware Sites Related to Biomedical Information Systems

    Directory of Open Access Journals (Sweden)

    Dohoon Kim

    2015-01-01

    Full Text Available Most advanced persistent threat attacks target web users through malicious code within landing (exploit or distribution sites. There is an urgent need to block the affected websites. Attacks on biomedical information systems are no exception to this issue. In this paper, we present a method for locating malicious websites that attempt to attack biomedical information systems. Our approach uses malicious code crawling to rearrange websites in the order of their risk index by analyzing the centrality between malware sites and proactively eliminates the root of these sites by finding the core-hub node, thereby reducing unnecessary security policies. In particular, we dynamically estimate the risk index of the affected websites by analyzing various centrality measures and converting them into a single quantified vector. On average, the proactive elimination of core malicious websites results in an average improvement in zero-day attack detection of more than 20%.

  11. Method for detecting core malware sites related to biomedical information systems.

    Science.gov (United States)

    Kim, Dohoon; Choi, Donghee; Jin, Jonghyun

    2015-01-01

    Most advanced persistent threat attacks target web users through malicious code within landing (exploit) or distribution sites. There is an urgent need to block the affected websites. Attacks on biomedical information systems are no exception to this issue. In this paper, we present a method for locating malicious websites that attempt to attack biomedical information systems. Our approach uses malicious code crawling to rearrange websites in the order of their risk index by analyzing the centrality between malware sites and proactively eliminates the root of these sites by finding the core-hub node, thereby reducing unnecessary security policies. In particular, we dynamically estimate the risk index of the affected websites by analyzing various centrality measures and converting them into a single quantified vector. On average, the proactive elimination of core malicious websites results in an average improvement in zero-day attack detection of more than 20%. PMID:25821511

  12. A System for Information Management in BioMedical Studies—SIMBioMS

    Science.gov (United States)

    Krestyaninova, Maria; Zarins, Andris; Viksna, Juris; Kurbatova, Natalja; Rucevskis, Peteris; Neogi, Sudeshna Guha; Gostev, Mike; Perheentupa, Teemu; Knuuttila, Juha; Barrett, Amy; Lappalainen, Ilkka; Rung, Johan; Podnieks, Karlis; Sarkans, Ugis; McCarthy, Mark I; Brazma, Alvis

    2009-01-01

    Summary: SIMBioMS is a web-based open source software system for managing data and information in biomedical studies. It provides a solution for the collection, storage, management and retrieval of information about research subjects and biomedical samples, as well as experimental data obtained using a range of high-throughput technologies, including gene expression, genotyping, proteomics and metabonomics. The system can easily be customized and has proven to be successful in several large-scale multi-site collaborative projects. It is compatible with emerging functional genomics data standards and provides data import and export in accepted standard formats. Protocols for transferring data to durable archives at the European Bioinformatics Institute have been implemented. Availability: The source code, documentation and initialization scripts are available at http://simbioms.org. Contact: support@simbioms.org; mariak@ebi.ac.uk PMID:19633095

  13. Predicting Lexical Relations between Biomedical Terms: towards a Multilingual Morphosemantics-based System.

    Science.gov (United States)

    Namer, Fiammetta; Baud, Robert

    2005-01-01

    This paper addresses the issue of how semantic information can be automatically assigned to compound terms, i.e. both a definition and a set of semantic relations. This issue is particularly crucial when elaborating multilingual databases and when developing cross-language information retrieval systems. The paper shows how morpho-semantics can contribute in the constitution of multilingual lexical networks in biomedical corpora. It presents a system capable of labelling terms with morphologically related words, i.e. providing them with a definition, and grouping them according to synonymy, hyponymy and proximity relations. The approach requires the interaction of three techniques: (1) a la morphosemantic parser, (2) a multilingual table defining basic relations between word roots, and (3) a set of language-independant rules to draw up the list of related terms. This approach has been fully implemented for French, on an about 29,000 terms biomedical lexicon, resulting to more than 3,000 lexical families. PMID:16160355

  14. NASA Ames Research Center R and D Services Directorate Biomedical Systems Development

    Science.gov (United States)

    Pollitt, J.; Flynn, K.

    1999-01-01

    The Ames Research Center R&D Services Directorate teams with NASA, other government agencies and/or industry investigators for the development, design, fabrication, manufacturing and qualification testing of space-flight and ground-based experiment hardware for biomedical and general aerospace applications. In recent years, biomedical research hardware and software has been developed to support space-flight and ground-based experiment needs including the E 132 Biotelemetry system for the Research Animal Holding Facility (RAHF), E 100 Neurolab neuro-vestibular investigation systems, the Autogenic Feedback Systems, and the Standard Interface Glove Box (SIGB) experiment workstation module. Centrifuges, motion simulators, habitat design, environmental control systems, and other unique experiment modules and fixtures have also been developed. A discussion of engineered systems and capabilities will be provided to promote understanding of possibilities for future system designs in biomedical applications. In addition, an overview of existing engineered products will be shown. Examples of hardware and literature that demonstrate the organization's capabilities will be displayed. The Ames Research Center R&D Services Directorate is available to support the development of new hardware and software systems or adaptation of existing systems to meet the needs of academic, commercial/industrial, and government research requirements. The Ames R&D Services Directorate can provide specialized support for: System concept definition and feasibility Mathematical modeling and simulation of system performance Prototype hardware development Hardware and software design Data acquisition systems Graphical user interface development Motion control design Hardware fabrication and high-fidelity machining Composite materials development and application design Electronic/electrical system design and fabrication System performance verification testing and qualification.

  15. High-Speed Imaging and Optical Sensing Systems for Biomedical Applications

    OpenAIRE

    Mahjoubfar, Ata

    2014-01-01

    High-throughput real-time optical sensing and imaging instruments for capture and analysis of fast phenomena are among the most essential tools for scientific, industrial, military, and most importantly biomedical applications. The key challenge in these instruments is the fundamental trade-off between speed and sensitivity of the measurement system due to the limited signal energy collected in each measurement window. Based on two enabling technologies, namely photonic time-stretch dispersiv...

  16. A Processable Shape Memory Polymer System for Biomedical Applications.

    Science.gov (United States)

    Hearon, Keith; Wierzbicki, Mark A; Nash, Landon D; Landsman, Todd L; Laramy, Christine; Lonnecker, Alexander T; Gibbons, Michael C; Ur, Sarah; Cardinal, Kristen O; Wilson, Thomas S; Wooley, Karen L; Maitland, Duncan J

    2015-06-24

    Polyurethane shape memory polymers (SMPs) with tunable thermomechanical properties and advanced processing capabilities are synthesized, characterized, and implemented in the design of a microactuator medical device prototype. The ability to manipulate glass transition temperature (Tg ) and crosslink density in low-molecular weight aliphatic thermoplastic polyurethane SMPs is demonstrated using a synthetic approach that employs UV catalyzed thiol-ene "click" reactions to achieve postpolymerization crosslinking. Polyurethanes containing varying C=C functionalization are synthesized, solution blended with polythiol crosslinking agents and photoinitiator and subjected to UV irradiation, and the effects of number of synthetic parameters on crosslink density are reported. Thermomechanical properties are highly tunable, including glass transitions tailorable between 30 and 105 °C and rubbery moduli tailorable between 0.4 and 20 MPa. This new SMP system exhibits high toughness for many formulations, especially in the case of low crosslink density materials, for which toughness exceeds 90 MJ m(-3) at select straining temperatures. To demonstrate the advanced processing capability and synthetic versatility of this new SMP system, a laser-actuated SMP microgripper device for minimally invasive delivery of endovascular devices is fabricated, shown to exhibit an average gripping force of 1.43 ± 0.37 N and successfully deployed in an in vitro experimental setup under simulated physiological conditions. PMID:25925212

  17. High-power green diode laser systems for biomedical applications

    DEFF Research Database (Denmark)

    Müller, André

    beam propagation parameters and therefore efficiently increases the brightness of compact and cost-effective diode laser systems. The condition of overlapping beams is an ideal scenario for subsequent frequency conversion. Based on sum-frequency generation of two beam combined diode lasers a 3.2 fold....... The underlying principle is spectral beam combining of multiple, comparable diode lasers with subsequent nonlinear frequency conversion. In the former approach multiple lasers are incoherently combined with an external optical component. With two 1062 nm tapered diode lasers and a reflecting volume...... Bragg grating more than 16 W of output power at combining efficiencies > 93% are obtained. Utilizing the wavelength tunability of diode lasers enables less critical optical alignment compared to lasers limited to specific atomic transitions. It is shown that spectral beam combining does not affect the...

  18. Implementation and management of a biomedical observation dictionary in a large healthcare information system

    Science.gov (United States)

    Vandenbussche, Pierre-Yves; Cormont, Sylvie; André, Christophe; Daniel, Christel; Delahousse, Jean; Charlet, Jean; Lepage, Eric

    2013-01-01

    Objective This study shows the evolution of a biomedical observation dictionary within the Assistance Publique Hôpitaux Paris (AP-HP), the largest European university hospital group. The different steps are detailed as follows: the dictionary creation, the mapping to logical observation identifier names and codes (LOINC), the integration into a multiterminological management platform and, finally, the implementation in the health information system. Methods AP-HP decided to create a biomedical observation dictionary named AnaBio, to map it to LOINC and to maintain the mapping. A management platform based on methods used for knowledge engineering has been put in place. It aims at integrating AnaBio within the health information system and improving both the quality and stability of the dictionary. Results This new management platform is now active in AP-HP. The AnaBio dictionary is shared by 120 laboratories and currently includes 50 000 codes. The mapping implementation to LOINC reaches 40% of the AnaBio entries and uses 26% of LOINC records. The results of our work validate the choice made to develop a local dictionary aligned with LOINC. Discussion and Conclusions This work constitutes a first step towards a wider use of the platform. The next step will support the entire biomedical production chain, from the clinician prescription, through laboratory tests tracking in the laboratory information system to the communication of results and the use for decision support and biomedical research. In addition, the increase in the mapping implementation to LOINC ensures the interoperability allowing communication with other international health institutions. PMID:23635601

  19. Wearable Biomedical Measurement Systems for Assessment of Mental Stress of Combatants in Real Time

    Directory of Open Access Journals (Sweden)

    Fernando Seoane

    2014-04-01

    Full Text Available The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants’ operational capabilities. Within this framework the ATREC project funded by the “Coincidente” program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems.

  20. Wearable biomedical measurement systems for assessment of mental stress of combatants in real time.

    Science.gov (United States)

    Seoane, Fernando; Mohino-Herranz, Inmaculada; Ferreira, Javier; Alvarez, Lorena; Buendia, Ruben; Ayllón, David; Llerena, Cosme; Gil-Pita, Roberto

    2014-01-01

    The Spanish Ministry of Defense, through its Future Combatant program, has sought to develop technology aids with the aim of extending combatants' operational capabilities. Within this framework the ATREC project funded by the "Coincidente" program aims at analyzing diverse biometrics to assess by real time monitoring the stress levels of combatants. This project combines multidisciplinary disciplines and fields, including wearable instrumentation, textile technology, signal processing, pattern recognition and psychological analysis of the obtained information. In this work the ATREC project is described, including the different execution phases, the wearable biomedical measurement systems, the experimental setup, the biomedical signal analysis and speech processing performed. The preliminary results obtained from the data analysis collected during the first phase of the project are presented, indicating the good classification performance exhibited when using features obtained from electrocardiographic recordings and electrical bioimpedance measurements from the thorax. These results suggest that cardiac and respiration activity offer better biomarkers for assessment of stress than speech, galvanic skin response or skin temperature when recorded with wearable biomedical measurement systems. PMID:24759113

  1. Biomedical Materials

    Institute of Scientific and Technical Information of China (English)

    CHANG Jiang; ZHOU Yanling

    2011-01-01

    @@ Biomedical materials, biomaterials for short, is regarded as "any substance or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as part of a system which treats, augments, or replaces any tissue, organ or function of the body" (Vonrecum & Laberge, 1995).Biomaterials can save lives, relieve suffering and enhance the quality of life for human being.

  2. Survey of biomedical and environental data bases, models, and integrated computer systems at Argonne National Laboratory

    International Nuclear Information System (INIS)

    This document contains an inventory (index) of information resources pertaining to biomedical and environmental projects at Argonne National Laboratory--the information resources include a data base, model, or integrated computer system. Entries are categorized as models, numeric data bases, bibliographic data bases, or integrated hardware/software systems. Descriptions of the Information Coordination Focal Point (ICFP) program, the system for compiling this inventory, and the plans for continuing and expanding it are given, and suggestions for utilizing the services of the ICFP are outlined

  3. Survey of biomedical and environental data bases, models, and integrated computer systems at Argonne National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Murarka, I.P.; Bodeau, D.J.; Scott, J.M.; Huebner, R.H.

    1978-08-01

    This document contains an inventory (index) of information resources pertaining to biomedical and environmental projects at Argonne National Laboratory--the information resources include a data base, model, or integrated computer system. Entries are categorized as models, numeric data bases, bibliographic data bases, or integrated hardware/software systems. Descriptions of the Information Coordination Focal Point (ICFP) program, the system for compiling this inventory, and the plans for continuing and expanding it are given, and suggestions for utilizing the services of the ICFP are outlined.

  4. Comment on 'Interpretation of the Lempel-Ziv Complexity Measure in the context of Biomedical Signal Analysis'

    CERN Document Server

    Balasubramanian, Karthi

    2013-01-01

    In this Communication, we express our reservations on some aspects of the interpretation of the Lempel-Ziv Complexity measure (LZ) by Mateo et al. in "Interpretation of the Lempel-Ziv complexity measure in the context of biomedical signal analysis," IEEE Trans. Biomed. Eng., vol. 53, no. 11, pp. 2282-2288, Nov. 2006. In particular, we comment on the dependence of the LZ complexity measure on number of harmonics, frequency content and amplitude modulation. We disagree with the following statements made by Mateo et al. 1. "LZ is not sensitive to the number of harmonics in periodic signals." 2. "LZ increases as the frequency of a sinusoid increases." 3. "Amplitude modulation of a signal doesnot result in an increase in LZ." We show the dependence of LZ complexity measure on harmonics and amplitude modulation by using a modified version of the synthetic signal that has been used in the original paper. Also, the second statement is a generic statement which is not entirely true. This is true only in the low freque...

  5. Complex Digital Visual Systems

    Science.gov (United States)

    Sweeny, Robert W.

    2013-01-01

    This article identifies possibilities for data visualization as art educational research practice. The author presents an analysis of the relationship between works of art and digital visual culture, employing aspects of network analysis drawn from the work of Barabási, Newman, and Watts (2006) and Castells (1994). Describing complex network…

  6. The Complex System in Babel

    OpenAIRE

    Dwi Setiawan; Liliek Soelistyo

    2008-01-01

    This article discusses how the plot of Babel reflects the principles of the quantum-physic theory of complex system such as complexity, indeterminacy and non-linearity. In terms of complexity, the movie exposes more than two distinct subplots with their subcomponents. Yet, every subplot is only meaningful when it is mentally put in relation to the others. Due to its complexity, it is highly difficult for the audience and the characters of Babel to determine the meaning or the significance of ...

  7. Science gateways for biomedical big data analysis

    NARCIS (Netherlands)

    S. Shahand

    2015-01-01

    Biomedical researchers are facing data deluge challenges such as dealing with large volume of complex heterogeneous data and complex and computationally demanding data processing methods. Such scale and complexity of biomedical research requires multi-disciplinary collaboration between scientists fr

  8. ON COMPLEXITY OF POWER SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    MA Jin; CHENG Daizhan; HONG Yiguang; SUN Yuanzhang

    2003-01-01

    The power system is a classical example of complex systems. In this paper it is shown that the power industry in China is facing a tremendous challenge. The complexity in power systems is investigated as follows. First, the cascade failure in power systems is analyzed, and compared with sand-pile model. Next, we show that the agent-based modelling is a proper way for power network. Mathematically, the geometric dynamics and differential inclusion are useful tools for the stability analysis of large scale power systems. As for power market, the game theory and generalized control system model are proposed. For a complex power system, an evolutive model may be more accurate in description and analysis. Finally, certain newly developed numerical methods in the power system computation are introduced. Overall, we are convinced that the theorem of complexity, combined with modern control theory, may be the right way to answer the challenges faced by the power industry in China.

  9. An analog front-end enables electrical impedance spectroscopy system on-chip for biomedical applications

    International Nuclear Information System (INIS)

    The increasing number of applications of electrical bioimpedance measurements in biomedical practice, together with continuous advances in textile technology, has encouraged several researchers to make the first attempts to develop portable, even wearable, electrical bioimpedance measurement systems. The main target of these systems is personal and home monitoring. Analog Devices has made available AD5933, a new system-on-chip fully integrated electrical impedance spectrometer, which might allow the implementation of minimum-size instrumentation for electrical bioimpedance measurements. However, AD5933 as such is not suitable for most applications of electrical bioimpedance. In this work, we present a relatively simple analog front-end that adapts AD5933 to a four-electrode strategy, allowing its use in biomedical applications for the first time. The resulting impedance measurements exhibit a very good performance in aspects like load dynamic range and accuracy. This type of minimum-size, system-on-chip-based bioimpedance measurement system would lead researchers to develop and implement light and wearable electrical bioimpedance systems for home and personal health monitoring applications, a new and huge niche for medical technology development

  10. Biomedical engineering principles

    CERN Document Server

    Ritter, Arthur B; Valdevit, Antonio; Ascione, Alfred N

    2011-01-01

    Introduction: Modeling of Physiological ProcessesCell Physiology and TransportPrinciples and Biomedical Applications of HemodynamicsA Systems Approach to PhysiologyThe Cardiovascular SystemBiomedical Signal ProcessingSignal Acquisition and ProcessingTechniques for Physiological Signal ProcessingExamples of Physiological Signal ProcessingPrinciples of BiomechanicsPractical Applications of BiomechanicsBiomaterialsPrinciples of Biomedical Capstone DesignUnmet Clinical NeedsEntrepreneurship: Reasons why Most Good Designs Never Get to MarketAn Engineering Solution in Search of a Biomedical Problem

  11. Biomedical optical imaging

    CERN Document Server

    Fujimoto, James G

    2009-01-01

    Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this tech

  12. Challenges in Complex Systems Science

    CERN Document Server

    Miguel, Maxi San; Kertesz, Janos; Kaski, Kimmo; Díaz-Guilera, Albert; MacKay, Robert S; Loreto, Vittorio; Erdi, Peter; Helbing, Dirk

    2012-01-01

    FuturICT foundations are social science, complex systems science, and ICT. The main concerns and challenges in the science of complex systems in the context of FuturICT are laid out in this paper with special emphasis on the Complex Systems route to Social Sciences. This include complex systems having: many heterogeneous interacting parts; multiple scales; complicated transition laws; unexpected or unpredicted emergence; sensitive dependence on initial conditions; path-dependent dynamics; networked hierarchical connectivities; interaction of autonomous agents; self-organisation; non-equilibrium dynamics; combinatorial explosion; adaptivity to changing environments; co-evolving subsystems; ill-defined boundaries; and multilevel dynamics. In this context, science is seen as the process of abstracting the dynamics of systems from data. This presents many challenges including: data gathering by large-scale experiment, participatory sensing and social computation, managing huge distributed dynamic and heterogeneou...

  13. High-Definition 3D Stereoscopic Microscope Display System for Biomedical Applications

    Directory of Open Access Journals (Sweden)

    Gi-Chang Park

    2010-01-01

    Full Text Available Biomedical research has been performed by using advanced information techniques, and micro-high-quality stereo images have been used by researchers and/or doctors for various aims in biomedical research and surgery. To visualize the stereo images, many related devices have been developed. However, the devices are difficult to learn for junior doctors and demanding to supervise for experienced surgeons. In this paper, we describe the development of a high-definition (HD three-dimensional (3D stereoscopic imaging display system for operating a microscope or experimenting on animals. The system consists of a stereoscopic camera part, image processing device for stereoscopic video recording, and stereoscopic display. In order to reduce eyestrain and viewer fatigue, we use a preexisting stereo microscope structure and polarized-light stereoscopic display method that does not reduce the quality of the stereo images. The developed system can overcome the discomfort of the eye piece and eyestrain caused by use over a long period of time.

  14. European Conference on Complex Systems

    CERN Document Server

    Pellegrini, Francesco; Caldarelli, Guido; Merelli, Emanuela

    2016-01-01

    This work contains a stringent selection of extended contributions presented at the meeting of 2014 and its satellite meetings, reflecting scope, diversity and richness of research areas in the field, both fundamental and applied. The ECCS meeting, held under the patronage of the Complex Systems Society, is an annual event that has become the leading European conference devoted to complexity science. It offers cutting edge research and unique opportunities to study novel scientific approaches in a multitude of application areas. ECCS'14, its eleventh occurrence, took place in Lucca, Italy. It gathered some 650 scholars representing a wide range of topics relating to complex systems research, with emphasis on interdisciplinary approaches. The editors are among the best specialists in the area. The book is of great interest to scientists, researchers and graduate students in complexity, complex systems and networks.

  15. Anomaly Detection for Complex Systems

    Data.gov (United States)

    National Aeronautics and Space Administration — In performance maintenance in large, complex systems, sensor information from sub-components tends to be readily available, and can be used to make predictions...

  16. HEALTHCARE: A COMPLEX SERVICE SYSTEM

    Institute of Scientific and Technical Information of China (English)

    James M. TIEN; Pascal J. GOLDSCHMIDT-CLERMONT

    2009-01-01

    Healthcare is indeed a complex service system, one requiring the technobiology approach of systems engineering to underpin its development as an integrated and adaptive system. In general, healthcare services are carried out with knowledge-intensive agents or components which work together as providers and consumers to create or co-produce value. Indeed, the engineering design of a healthcare system must recognize the fact that it is actually a complex integration of human-centered activities that is increasingly dependent on information technology and knowledge. Like any service system, healthcare can be considered to be a combination or recombination of three essential components-people (characterized by behaviors, values, knowledge, etc.), processes (characterized by collaboration, customization, etc.) and products (characterized by software, hardware, infrastructures, etc.). Thus, a healthcare system is an integrated and adaptive set of people, processes and products. It is, in essence, a system of systems which objectives are to enhance its efficiency (leading to greater interdependency) and effectiveness (leading to improved health). Integration occurs over the physical, temporal, organizational and functional dimensions, while adaptation occurs over the monitoring, feedback, cybernetic and learning dimensions. In sum, such service systems as healthcare are indeed complex, especially due to the uncertainties associated with the human-centered aspects of these systems. Moreover, the system complexities can only be dealt with methods that enhance system integration and adaptation.

  17. Thiol-ene crosslinking polyamidoamine dendrimer-hyaluronic acid hydrogel system for biomedical applications.

    Science.gov (United States)

    Bi, Xiangdong; Liang, Aiye; Tan, Yu; Maturavongsadit, Panita; Higginbothem, Ashley; Gado, Togor; Gramling, Abigail; Bahn, Hanna; Wang, Qian

    2016-06-01

    A series of alkene functionalized polyamidoamine (PAMAM) dendrimers were synthesized to prepare in situ forming hydrogels with varied gelation time and mechanical properties through crosslinking with thiolated hyaluronic acid (HS-HA). By varying the alkenyl groups on the dendrimers, the gelation time displayed a large range from 8 seconds to 18 hours, and the modulus of the hydrogels ranged from 36 to 183 Pa under experimental conditions. Investigation by (1)H-NMR spectroscopy revealed that the gelation time and the stiffness of the hydrogels were governed by the degree of electron deficiency of alkenyl groups on the dendrimers. This research provided a systematic study on the relationship between chemical structures versus gelation time and mechanical properties of hydrogels, which could guide the way to synthesize in situ forming hydrogels with designated gelation time and stiffness for biomedical applications. Further, a RGD peptide was attached to the PAMAM dendrimers to enhance cell attachment and proliferation. Viability assays of Human Umbilical Vein Endothelial Cells (HUVEC) in the synthesized hydrogels demonstrated the biocompatibility of the hydrogels after 48 hours of culturing, and the RGD peptide improved the viability of HUVEC cells in hydrogels. We believe the PAMAM/HA hydrogel system is a tuneable and biocompatible system for diverse biomedical applications. PMID:26923639

  18. An intelligent monitoring and management system for cross-enterprise biomedical data sharing platform

    Science.gov (United States)

    Wang, Tusheng; Yang, Yuanyuan; Zhang, Jianguo

    2013-03-01

    In order to enable multiple disciplines of medical researchers, clinical physicians and biomedical engineers working together in a secured, efficient, and transparent cooperative environment, we had designed an e-Science platform for biomedical imaging research and application cross multiple academic institutions and hospitals in Shanghai by using grid-based or cloud-based distributed architecture and presented this work in SPIE Medical Imaging conference held in San Diego in 2012. However, when the platform integrates more and more nodes over different networks, the first challenge is that how to monitor and maintain all the hosts and services operating cross multiple academic institutions and hospitals in the e-Science platform, such as DICOM and Web based image communication services, messaging services and XDS ITI transaction services. In this presentation, we presented a system design and implementation of intelligent monitoring and management which can collect system resource status of every node in real time, alert when node or service failure occurs, and can finally improve the robustness, reliability and service continuity of this e-Science platform.

  19. Defining and relating biomedical terms: towards a cross-language morphosemantics-based system.

    Science.gov (United States)

    Namer, Fiammetta; Baud, Robert

    2007-01-01

    This paper addresses the issue of how semantic information can be automatically assigned to compound terms, i.e. both a definition and a set of semantic relations. This is particularly crucial when elaborating multilingual databases and when developing cross-language information retrieval systems. The paper shows how morphosemantics can contribute in the constitution of multilingual lexical networks in biomedical corpora. It presents a system capable of labelling terms with morphologically related words, i.e. providing them with a definition, and grouping them according to synonymy, hyponymy and proximity relations. The approach requires the interaction of three techniques: (1) a language-specific morphosemantic parser, (2) a multilingual table defining basic relations between word roots and (3) a set of language-independent rules to draw up the list of related terms. This approach has been fully implemented for French, on an about 29,000 terms biomedical lexicon, resulting to more than 3000 lexical families. A validation of the results against a manually annotated file by experts of the domain is presented, followed by a discussion of our method. PMID:16814603

  20. Decentralized control of complex systems

    CERN Document Server

    Siljak, Dragoslav D

    2011-01-01

    Complex systems require fast control action in response to local input, and perturbations dictate the use of decentralized information and control structures. This much-cited reference book explores the approaches to synthesizing control laws under decentralized information structure constraints.Starting with a graph-theoretic framework for structural modeling of complex systems, the text presents results related to robust stabilization via decentralized state feedback. Subsequent chapters explore optimization, output feedback, the manipulative power of graphs, overlapping decompositions and t

  1. Challenges in complex systems science

    Science.gov (United States)

    San Miguel, M.; Johnson, J. H.; Kertesz, J.; Kaski, K.; Díaz-Guilera, A.; MacKay, R. S.; Loreto, V.; Érdi, P.; Helbing, D.

    2012-11-01

    FuturICT foundations are social science, complex systems science, and ICT. The main concerns and challenges in the science of complex systems in the context of FuturICT are laid out in this paper with special emphasis on the Complex Systems route to Social Sciences. This include complex systems having: many heterogeneous interacting parts; multiple scales; complicated transition laws; unexpected or unpredicted emergence; sensitive dependence on initial conditions; path-dependent dynamics; networked hierarchical connectivities; interaction of autonomous agents; self-organisation; non-equilibrium dynamics; combinatorial explosion; adaptivity to changing environments; co-evolving subsystems; ill-defined boundaries; and multilevel dynamics. In this context, science is seen as the process of abstracting the dynamics of systems from data. This presents many challenges including: data gathering by large-scale experiment, participatory sensing and social computation, managing huge distributed dynamic and heterogeneous databases; moving from data to dynamical models, going beyond correlations to cause-effect relationships, understanding the relationship between simple and comprehensive models with appropriate choices of variables, ensemble modeling and data assimilation, modeling systems of systems of systems with many levels between micro and macro; and formulating new approaches to prediction, forecasting, and risk, especially in systems that can reflect on and change their behaviour in response to predictions, and systems whose apparently predictable behaviour is disrupted by apparently unpredictable rare or extreme events. These challenges are part of the FuturICT agenda.

  2. Studies on thermo-optic property of chitosan–alizarin yellow GG complex: a direction for devices for biomedical applications

    Indian Academy of Sciences (India)

    Nidhi Nigam; Santosh Kumar; Pradip Kumar Dutta; Tamal Ghosh

    2015-10-01

    The optical parameters including the refractive index () and thermo-optic coefficient, TOC (d/d), the dielectric constant () and its variation with temperature, and the thermal volume expansion coefficient () and its variation with temperature of chitosan–alizarin yellow GG (CS–AY GG) complex were examined. The dn/dT and - values for the polymer derivative were in the range −2.5 × 10−4 to 1.2 × 10−4° C−1 and 2.2 to 2.3, respectively. The dn/dT values were larger than that of inorganic glasses such as zinc silicate glass (5.5 × 10−6° C−1) and borosilicate glass (4.1 × 10−6° C−1) and were larger than that of organic polymers such as polystyrene (−1.23 × 10−4 ° C−1) and PMMA (−1.20 × 10−4 ° C−1). The -values are lower than optically estimated -values of conventional polymer (3.00), aliphatic polyimide (2.5) and semi-aromatic polyamide (2.83). The obtained results of chitosan derivative are expected to be useful for optical switching and optical waveguide areas for devices of biomedical applications.

  3. Ultrasonic compatibilization of polyelectrolyte complex based on polysaccharides for biomedical applications.

    Science.gov (United States)

    Belluzo, M Soledad; Medina, Lara F; Cortizo, Ana M; Cortizo, M Susana

    2016-05-01

    In recent years, there has been an increasing interest in the design of biomaterials for cartilage tissue engineering. This type of materials must meet several requirements. In this study, we apply ultrasound to prepare a compatibilized blend of polyelectrolyte complexes (PEC) based on carboxymethyl cellulose (CMC) and chitosan (CHI), in order to improve stability and mechanical properties through the inter-polymer macroradicals coupling produced by sonochemical reaction. We study the kinetic of the sonochemical degradation of each component in order to optimize the experimental conditions for PEC compatibilization. Scaffolds obtained applying this methodology and scaffolds without ultrasound processing were prepared and their morphology (by scanning electron microscopy), polyelectrolyte interactions (by FTIR), stability and mechanical properties were analyzed. The swelling kinetics was studied and interpreted based on the structural differences between the two kinds of scaffolds. In addition we evaluate the possible in vitro cytotoxicity of the scaffolds using macrophage cells in culture. Our results demonstrate that the ultrasound is a very efficient methodology to compatibilize PEC, exhibiting improved properties compared with the simple mixture of the two polysaccharides. The test with murine macrophage RAW 264.7 cells showed no evince of cytotoxicity, suggesting that PEC biomaterials obtained under ultrasound conditions could be useful in the cartilage tissue engineering field. PMID:26703196

  4. Consideration for solar system exploration - A system to Mars. [biomedical, environmental, and psychological factors

    Science.gov (United States)

    Nicogossian, Arnauld E.; Garshnek, Victoria

    1989-01-01

    Biomedical issues related to a manned mission to Mars are reviewed. Consideration is given to cardiovascular deconditioning, hematological and immunological changes, bone and muscle changes, nutritional issues, and the development of physiological countermeasures. Environmental issues are discussed, including radiation hazards, toxic chemical exposure, and the cabin environment. Also, human factors, performance and behavior, medical screening of the crew, disease prediction, and health maintenance are examined.

  5. A Follow-Up Study of Medical Students' Biomedical Understanding and Clinical Reasoning Concerning the Cardiovascular System

    Science.gov (United States)

    Ahopelto, Ilona; Mikkila-Erdmann, Mirjamaija; Olkinuora, Erkki; Kaapa, Pekka

    2011-01-01

    Novice medical students usually hold initial conceptions concerning medical domains, such as the cardiovascular system, which may contradict scientific explanations and thus hinder learning. The purpose of this study was to investigate which kinds of biomedical representations medical students constructed of the central cardiovascular system in…

  6. 1998 Complex Systems Summer School

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-15

    For the past eleven years a group of institutes, centers, and universities throughout the country have sponsored a summer school in Santa Fe, New Mexico as part of an interdisciplinary effort to promote the understanding of complex systems. The goal of these summer schools is to provide graduate students, postdoctoral fellows and active research scientists with an introduction to the study of complex behavior in mathematical, physical, and living systems. The Center for Nonlinear Studies supported the eleventh in this series of highly successful schools in Santa Fe in June, 1998.

  7. Pluralistic Modeling of Complex Systems

    CERN Document Server

    Helbing, Dirk

    2010-01-01

    The modeling of complex systems such as ecological or socio-economic systems can be very challenging. Although various modeling approaches exist, they are generally not compatible and mutually consistent, and empirical data often do not allow one to decide what model is the right one, the best one, or most appropriate one. Moreover, as the recent financial and economic crisis shows, relying on a single, idealized model can be very costly. This contribution tries to shed new light on problems that arise when complex systems are modeled. While the arguments can be transferred to many different systems, the related scientific challenges are illustrated for social, economic, and traffic systems. The contribution discusses issues that are sometimes overlooked and tries to overcome some frequent misunderstandings and controversies of the past. At the same time, it is highlighted how some long-standing scientific puzzles may be solved by considering non-linear models of heterogeneous agents with spatio-temporal inte...

  8. Leveraging dialog systems research to assist biomedical researchers' interrogation of Big Clinical Data.

    Science.gov (United States)

    Hoxha, Julia; Weng, Chunhua

    2016-06-01

    The worldwide adoption of electronic health records (EHR) promises to accelerate clinical research, which lies at the heart of medical advances. However, the interrogation of such Big Data by clinical researchers can be laborious and error-prone, involving iterative and ineffective communication of data requests to data analysts. Research on this communication process is rare. There also exists no contemporary system that offers intelligent solutions to assist clinical researchers in their quest for clinical data. In this article, we first provide a detailed characterization of the challenges encountered in this communication space. Second, we identify promising synergies between fields studying human-to-human and human-machine communication that can shed light on biomedical data query mediation. We propose a mixed-initiative dialog-based approach to support autonomous clinical data access and recommend needed technology development and communication study for accelerating clinical research. PMID:27067901

  9. The Complex System in Babel

    Directory of Open Access Journals (Sweden)

    Dwi Setiawan

    2008-01-01

    Full Text Available This article discusses how the plot of Babel reflects the principles of the quantum-physic theory of complex system such as complexity, indeterminacy and non-linearity. In terms of complexity, the movie exposes more than two distinct subplots with their subcomponents. Yet, every subplot is only meaningful when it is mentally put in relation to the others. Due to its complexity, it is highly difficult for the audience and the characters of Babel to determine the meaning or the significance of a component in the story. Finally, Babel also displays the phenomena of non-linearity and chaos. Babel's non-linearity expresses both positive and negative feedback loops, with the first being dominant. This is largely responsible for the chaotic development of the plot.

  10. Injection Molding of Titanium Alloy Implant For Biomedical Application Using Novel Binder System Based on Palm Oil Derivatives

    Directory of Open Access Journals (Sweden)

    R. Ibrahim

    2010-01-01

    Full Text Available Problem statement: Titanium alloy (Ti6Al4V has been widely used as an implant for biomedical application. In this study, the implant had been fabricated using high technology of Powder Injection Molding (PIM process due to the cost effective technique for producing small, complex and precision parts in high volume compared with conventional method through machining. Approach: Through PIM, the binder system is one of the most important criteria in order to successfully fabricate the implants. Even though, the binder system is a temporary, but failure in the selection and removal of the binder system will affect on the final properties of the sintered parts. Therefore, the binder system based on palm oil derivative which is palm stearin had been formulated and developed to replace the conventional binder system. Results: The rheological studies of the mixture between the powder and binders system had been determined properly in order to be successful during injection into injection molding machine. After molding, the binder held the particles in place. The binder system had to be removed completely through debinding step. During debinding step, solvent debinding and thermal pyrolysis had been used to remove completely of the binder system. The debound part was then sintered to give the required physical and mechanical properties. The in vitro biocompatibility also was tested using Neutral Red (NR and mouse fibroblast cell lines L-929 for the direct contact assay. Conclusion: The results showed that the properties of the final sintered parts fulfill the Standard Metal Powder Industries Federation (MPIF 35 for PIM parts except for tensile strength and elongation due to the formation of titanium carbide. The in vitro biocompatibility on the extraction using mouse fibroblast cell line L-929 by means of NR assays showed non toxic for the sintered specimen titanium alloy parts.

  11. UNMANNED AIRCRAFT SYSTEMS AS COMPLEX MULTISTRUCTURAL SYSTEM

    Directory of Open Access Journals (Sweden)

    A. S. Abufanas

    2015-08-01

    Full Text Available The principles of constructing mathematical models of unmanned aircraft systems as complex systems consisting of a plurality ofsubsystems, each of which is considered as a system. In this case, the relationship between the subsystems are described by equations based on the topological graph theory, and for the preparation of component equations describing the dynamics of the subsystems is proposed to use differential equations discontinuous type based on systems theory of random structure.

  12. Preconditioning Complex Symmetric Linear Systems

    Directory of Open Access Journals (Sweden)

    Enrico Bertolazzi

    2015-01-01

    Full Text Available A new preconditioner for symmetric complex linear systems based on Hermitian and skew-Hermitian splitting (HSS for complex symmetric linear systems is herein presented. It applies to conjugate orthogonal conjugate gradient (COCG or conjugate orthogonal conjugate residual (COCR iterative solvers and does not require any estimation of the spectrum of the coefficient matrix. An upper bound of the condition number of the preconditioned linear system is provided. To reduce the computational cost the preconditioner is approximated with an inexact variant based on incomplete Cholesky decomposition or on orthogonal polynomials. Numerical results show that the present preconditioner and its inexact variant are efficient and robust solvers for this class of linear systems. A stability analysis of the inexact polynomial version completes the description of the preconditioner.

  13. Bilinear effect in complex systems

    CERN Document Server

    Lam, Lui; Han, Xiao-Pu; Liu, Chih-Hui Alston; Shu, Chang-Qing; Wei, Zhengjin; Zhou, Tao; Zhu, Jichen

    2010-01-01

    A new, generic type of Zipf-plot behavior in complex systems has been discovered. This Zipf plot does not obey the power law or stretched-exponent distribution but appears as two monotonically decreasing straight lines intersecting each other. This is called the Bilinear Effect. Examples from real systems (including lifetime distributions of Chinese dynasties) are presented. A 3-layer network model that leads to the bilinear effect is given.

  14. COOPERATIVE BEHAVIOUR IN COMPLEX SYSTEMS

    OpenAIRE

    Karsai Márton

    2009-01-01

    In my PhD thesis I studied cooperative phenomena arise in complex systems using the methods of statistical and computational physics. The aim of my work was also to study the critical behaviour of interacting many-body systems during their phase transitions and describe their universal features analytically and by means of numerical calculations. In order to do so I completed studies in four different subjects. My first investigated subject was a study of non-equilibrium phase transitions in ...

  15. A Multilayer Secure Biomedical Data Management System for Remotely Managing a Very Large Number of Diverse Personal Healthcare Devices

    Directory of Open Access Journals (Sweden)

    KeeHyun Park

    2015-01-01

    Full Text Available In this paper, a multilayer secure biomedical data management system for managing a very large number of diverse personal health devices is proposed. The system has the following characteristics: the system supports international standard communication protocols to achieve interoperability. The system is integrated in the sense that both a PHD communication system and a remote PHD management system work together as a single system. Finally, the system proposed in this paper provides user/message authentication processes to securely transmit biomedical data measured by PHDs based on the concept of a biomedical signature. Some experiments, including the stress test, have been conducted to show that the system proposed/constructed in this study performs very well even when a very large number of PHDs are used. For a stress test, up to 1,200 threads are made to represent the same number of PHD agents. The loss ratio of the ISO/IEEE 11073 messages in the normal system is as high as 14% when 1,200 PHD agents are connected. On the other hand, no message loss occurs in the multilayered system proposed in this study, which demonstrates the superiority of the multilayered system to the normal system with regard to heavy traffic.

  16. Empirical and theoretical analysis of complex systems

    Science.gov (United States)

    Zhao, Guannan

    This thesis is an interdisciplinary work under the heading of complexity science which focuses on an arguably common "hard" problem across physics, finance and biology [1], to quantify and mimic the macroscopic "emergent phenomenon" in large-scale systems consisting of many interacting "particles" governed by microscopic rules. In contrast to traditional statistical physics, we are interested in systems whose dynamics are subject to feedback, evolution, adaption, openness, etc. Global financial markets, like the stock market and currency market, are ideal candidate systems for such a complexity study: there exists a vast amount of accurate data, which is the aggregate output of many autonomous agents continuously competing with each other. We started by examining the ultrafast "mini flash crash (MFC)" events in the US stock market. An abrupt system-wide composition transition from a mixed human machine phase to a new all-machine phase is uncovered, and a novel theory developed to explain this observation. Then in the study of FX market, we found an unexpected variation in the synchronicity of price changes in different market subsections as a function of the overall trading activity. Several survival models have been tested in analyzing the distribution of waiting times to the next price change. In the region of long waiting-times, the distribution for each currency pair exhibits a power law with exponent in the vicinity of 3.5. By contrast, for short waiting times only, the market activity can be mimicked by the fluctuations emerging from a finite resource competition model containing multiple agents with limited rationality (so called El Farol Model). Switching to the biomedical domain, we present a minimal mathematical model built around a co-evolving resource network and cell population, yielding good agreement with primary tumors in mice experiment and with clinical metastasis data. In the quest to understand contagion phenomena in systems where social group

  17. Permutation Complexity in Dynamical Systems

    CERN Document Server

    Amigo, Jose

    2010-01-01

    The study of permutation complexity can be envisioned as a new kind of symbolic dynamics whose basic blocks are ordinal patterns, that is, permutations defined by the order relations among points in the orbits of dynamical systems. Since its inception in 2002 the concept of permutation entropy has sparked a new branch of research in particular regarding the time series analysis of dynamical systems that capitalizes on the order structure of the state space. Indeed, on one hand ordinal patterns and periodic points are closely related, yet ordinal patterns are amenable to numerical methods, while periodicity is not. Another interesting feature is that since it can be shown that random (unconstrained) dynamics has no forbidden patterns with probability one, their existence can be used as a fingerprint to identify any deterministic origin of orbit generation. This book is primarily addressed to researchers working in the field of nonlinear dynamics and complex systems, yet will also be suitable for graduate stude...

  18. Is there a need for biomedical CBIR systems in clinical practice? Outcomes from a usability study

    Science.gov (United States)

    Antani, Sameer; Xue, Zhiyun; Long, L. Rodney; Bennett, Deborah; Ward, Sarah; Thoma, George R.

    2011-03-01

    Articles in the literature routinely describe advances in Content Based Image Retrieval (CBIR) and its potential for improving clinical practice, biomedical research and education. Several systems have been developed to address particular needs, however, surprisingly few are found to be in routine practical use. Our collaboration with the National Cancer Institute (NCI) has identified a need to develop tools to annotate and search a collection of over 100,000 cervigrams and related, anonymized patient data. One such tool developed for a projected need for retrieving similar patient images is the prototype CBIR system, called CervigramFinder, which retrieves images based on the visual similarity of particular regions on the cervix. In this article we report the outcomes from a usability study conducted at a primary meeting of practicing experts. We used the study to not only evaluate the system for software errors and ease of use, but also to explore its "user readiness", and to identify obstacles that hamper practical use of such systems, in general. Overall, the participants in the study found the technology interesting and bearing great potential; however, several challenges need to be addressed before the technology can be adopted.

  19. Mining biomedical images towards valuable information retrieval in biomedical and life sciences

    Science.gov (United States)

    Ahmed, Zeeshan; Zeeshan, Saman; Dandekar, Thomas

    2016-01-01

    Biomedical images are helpful sources for the scientists and practitioners in drawing significant hypotheses, exemplifying approaches and describing experimental results in published biomedical literature. In last decades, there has been an enormous increase in the amount of heterogeneous biomedical image production and publication, which results in a need for bioimaging platforms for feature extraction and analysis of text and content in biomedical images to take advantage in implementing effective information retrieval systems. In this review, we summarize technologies related to data mining of figures. We describe and compare the potential of different approaches in terms of their developmental aspects, used methodologies, produced results, achieved accuracies and limitations. Our comparative conclusions include current challenges for bioimaging software with selective image mining, embedded text extraction and processing of complex natural language queries. PMID:27538578

  20. A high-efficiency power and data transmission system for biomedical implanted electronic devices

    Science.gov (United States)

    Hamici, Zoubir; Itti, Roland; Champier, Jacques

    1996-02-01

    In biomedical engineering, inductive transcutaneous links can be used for power and data transfer between external systems and implanted electronic devices. The development of a micro-telemeter having a significant implantation depth needs a high-efficiency magnetic transcutaneous link. This paper presents a new system, which uses a multi-frequency load network for transmitter coil based on the class E power amplifier. At the carrier frequency used, the resistive load is influenced by the coupling of the coils and by the variation of the implant equivalent resistance. Modulating this latter between two rails permits one to modulate the amplitude of the external transmitter current and then to transmit internal data without the use of the classical implanted emitter design. Furthermore, the fact that the modulation index depends on the coupling factor, allows one to find the external coil's correct position using a position feedback loop. A complete study of the concept of digital data transmission by impedance modulation associated with a class E power amplifier is presented. Internal data transmission using this system yields a decrease of the internal electronic circuitry bulk and constitutes a high-efficiency energizing device. A theoretical investigation shows that the efficiency of the power transfer varies between 44 and 75% within a wide range of implantation depths (20 - 40 mm).

  1. Simulation of complex molecular systems

    International Nuclear Information System (INIS)

    The combined evolution of the electronic structure softwares and computational capabilities makes quantum molecular dynamics simulations available for increasingly complex systems, up to several hundred atoms. Among the various ab initio techniques, Density Functional Theory (DFT) is very successful due to its important computational efficiency with respect to Hartree-Fock type approaches. Its combination with empirical treatments of the weak van der Waals interactions allows the simulation of equilibrium or dynamics properties of numerous systems of interest for the nuclear and defense industry. We present 3 direct applications of quantum molecular dynamics: the determination of the structure of the complex Pu(DTPA) ion where DTPA means diethylen-triamine-penta-acid, the calculation of the equation of state and the Hugoniot curve of TATB monocrystal. (authors)

  2. Description complexity of lindenmayer systems

    OpenAIRE

    SELAMAT, H.; Mavlankulov, G.; Othman, M.; S. Turaev

    2012-01-01

    In this paper we study the nonterminal complexity of Lindenmayer systems withrespect to tree controlled grammars. We show that all 0L, D0Land E0L languages can begenerated by tree controlled grammars with at most five nonterminals. The results based onthe idea of using a tree controlled grammar in the t-normal form, which has the one activenonterminal, and a coding homomorphism

  3. Description complexity of lindenmayer systems

    Directory of Open Access Journals (Sweden)

    H. Selamat

    2012-12-01

    Full Text Available In this paper we study the nonterminal complexity of Lindenmayer systems withrespect to tree controlled grammars. We show that all 0L, D0Land E0L languages can begenerated by tree controlled grammars with at most five nonterminals. The results based onthe idea of using a tree controlled grammar in the t-normal form, which has the one activenonterminal, and a coding homomorphism

  4. 7th International Conference on Complex Systems

    CERN Document Server

    Braha, Dan; Bar-Yam, Yaneer

    2012-01-01

    The International Conference on Complex Systems (ICCS) creates a unique atmosphere for scientists of all fields, engineers, physicians, executives, and a host of other professionals to explore common themes and applications of complex system science. With this new volume, Unifying Themes in Complex Systems continues to build common ground between the wide-ranging domains of complex system science.

  5. 5th International Conference on Complex Systems

    CERN Document Server

    Braha, Dan; Bar-Yam, Yaneer

    2011-01-01

    The International Conference on Complex Systems (ICCS) creates a unique atmosphere for scientists of all fields, engineers, physicians, executives, and a host of other professionals to explore common themes and applications of complex system science. With this new volume, Unifying Themes in Complex Systems continues to build common ground between the wide-ranging domains of complex system science.

  6. Testing Complex and Embedded Systems

    CERN Document Server

    Pries, Kim H

    2010-01-01

    Many enterprises regard system-level testing as the final piece of the development effort, rather than as a tool that should be integrated throughout the development process. As a consequence, test teams often execute critical test plans just before product launch, resulting in much of the corrective work being performed in a rush and at the last minute. Presenting combinatorial approaches for improving test coverage, Testing Complex and Embedded Systems details techniques to help you streamline testing and identify problems before they occur--including turbocharged testing using Six Sigma and

  7. Complex Phenomena in Nanoscale Systems

    CERN Document Server

    Casati, Giulio

    2009-01-01

    Nanoscale physics has become one of the rapidly developing areas of contemporary physics because of its direct relevance to newly emerging area, nanotechnologies. Nanoscale devices and quantum functional materials are usually constructed based on the results of fundamental studies on nanoscale physics. Therefore studying physical phenomena in nanosized systems is of importance for progressive development of nanotechnologies. In this context study of complex phenomena in such systems and using them for controlling purposes is of great practical importance. Namely, such studies are brought together in this book, which contains 27 papers on various aspects of nanoscale physics and nonlinear dynamics.

  8. Generating Explanations for Biomedical Queries

    OpenAIRE

    Erdem, Esra; Oztok, Umut

    2013-01-01

    We introduce novel mathematical models and algorithms to generate (shortest or k different) explanations for biomedical queries, using answer set programming. We implement these algorithms and integrate them in BIOQUERY-ASP. We illustrate the usefulness of these methods with some complex biomedical queries related to drug discovery, over the biomedical knowledge resources PHARMGKB, DRUGBANK, BIOGRID, CTD, SIDER, DISEASE ONTOLOGY and ORPHADATA. To appear in Theory and Practice of Logic Program...

  9. Problem Solving and Complex Systems

    CERN Document Server

    Guinand, Frédéric

    2008-01-01

    The observation and modeling of natural Complex Systems (CSs) like the human nervous system, the evolution or the weather, allows the definition of special abilities and models reusable to solve other problems. For instance, Genetic Algorithms or Ant Colony Optimizations are inspired from natural CSs to solve optimization problems. This paper proposes the use of ant-based systems to solve various problems with a non assessing approach. This means that solutions to some problem are not evaluated. They appear as resultant structures from the activity of the system. Problems are modeled with graphs and such structures are observed directly on these graphs. Problems of Multiple Sequences Alignment and Natural Language Processing are addressed with this approach.

  10. An RFID-Based Closed-Loop Wireless Power Transmission System for Biomedical Applications

    Science.gov (United States)

    Kiani, Mehdi; Ghovanloo, Maysam

    2010-01-01

    This brief presents a standalone closed-loop wireless power transmission system that is built around a commercial off-the-shelf (COTS) radio-frequency identification (RFID) reader (TRF7960) operating at 13.56 MHz. It can be used for inductively powering implantable biomedical devices in a closed loop. Any changes in the distance and misalignment between transmitter and receiver coils in near-field wireless power transmission can cause a significant change in the received power, which can cause either a malfunction or excessive heat dissipation. RFID circuits are often used in an open loop. However, their back telemetry capability can be utilized to stabilize the received voltage on the implant. Our measurements showed that the delivered power to the transponder was maintained at 11.2 mW over a range of 0.5 to 2 cm, while the transmitter power consumption changed from 78 mW to 1.1 W. The closed-loop system can also oppose voltage variations as a result of sudden changes in the load current. PMID:21179391

  11. Organization of Biomedical Data for Collaborative Scientific Research: A Research Information Management System

    OpenAIRE

    Myneni, Sahiti; Patel, Vimla L.

    2010-01-01

    Biomedical researchers often work with massive, detailed and heterogeneous datasets. These datasets raise new challenges of information organization and management for scientific interpretation, as they demand much of the researchers’ time and attention. The current study investigated the nature of the problems that researchers face when dealing with such data. Four major problems identified with existing biomedical scientific information management methods were related to data organization, ...

  12. High-Definition 3D Stereoscopic Microscope Display System for Biomedical Applications

    OpenAIRE

    Yoo Kwan-Hee; Park Gi-Chang; Hong Jong-Myeon; Kwon Ki-Chul; Lim Young-Tae; Kim Nam

    2010-01-01

    Biomedical research has been performed by using advanced information techniques, and micro-high-quality stereo images have been used by researchers and/or doctors for various aims in biomedical research and surgery. To visualize the stereo images, many related devices have been developed. However, the devices are difficult to learn for junior doctors and demanding to supervise for experienced surgeons. In this paper, we describe the development of a high-definition (HD) three-dimensional (3D...

  13. Computational models of complex systems

    CERN Document Server

    Dabbaghian, Vahid

    2014-01-01

    Computational and mathematical models provide us with the opportunities to investigate the complexities of real world problems. They allow us to apply our best analytical methods to define problems in a clearly mathematical manner and exhaustively test our solutions before committing expensive resources. This is made possible by assuming parameter(s) in a bounded environment, allowing for controllable experimentation, not always possible in live scenarios. For example, simulation of computational models allows the testing of theories in a manner that is both fundamentally deductive and experimental in nature. The main ingredients for such research ideas come from multiple disciplines and the importance of interdisciplinary research is well recognized by the scientific community. This book provides a window to the novel endeavours of the research communities to present their works by highlighting the value of computational modelling as a research tool when investigating complex systems. We hope that the reader...

  14. COMPLEX ECO-ECONOMY SYSTEM

    Institute of Scientific and Technical Information of China (English)

    Pawel Bartoszczuk; Yoshiteru Nakamori

    2003-01-01

    In the past there were a lot of researches on the topic of economic growth. Nevertheless, the environment has been a bit abstracted by standard economics. Scarce natural resources and our choices to protect them or exploit them jointly determine the economic and environmental systems. In this paper we describe a model with a particular focus on the relationship among income, pollution, and non-renewable resources. We want to combine both economic and environmental sectors. The system dynamics approach is used in analyzing these complex relationships. This paper gives an insight into the possibilities for replacing non-renewable resources with more renewable ones. Next, we present the simulation runs of the model that are conducted with the help of existing system dynamics modeling tools. Only the relationships simulated so far between the variables ought to be put under yet more cautious examination.

  15. Fractional Order and non-linear System Identification algorithms for Biomedical applications

    International Nuclear Information System (INIS)

    We discuss the modelling of dielectric responses of amorphous biological samples. Such samples are commonly encountered in impedance spectroscopy studies as well as in UV, IR, optical and THz transient spectroscopy experiments and in pump-probe studies. In many occasions, the samples may display quenched absorption bands. A systems identification framework may be developed to provide parsimonious representations of such responses. To achieve this, it is appropriate to augment the standard models found in the identification literature to incorporate fractional order dynamics. Extensions of models using the forward shift operator, state space models as well as their non-linear Hammerstein-Wiener counterpart models are highlighted. We also discuss the need to extend the theory of electromagnetically excited networks which can account for fractional order behaviour in the non-linear regime by incorporating nonlinear elements to account for the observed non-linearities. The proposed approach leads to the development of a range of new chemometrics tools for biomedical data analysis and classification

  16. Modeling Power Systems as Complex Adaptive Systems

    Energy Technology Data Exchange (ETDEWEB)

    Chassin, David P.; Malard, Joel M.; Posse, Christian; Gangopadhyaya, Asim; Lu, Ning; Katipamula, Srinivas; Mallow, J V.

    2004-12-30

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today's most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This report explores the state-of-the-art physical analogs for understanding the behavior of some econophysical systems and deriving stable and robust control strategies for using them. We review and discuss applications of some analytic methods based on a thermodynamic metaphor, according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood. We apply these methods to the question of how power markets can be expected to behave under a variety of conditions.

  17. Thermodynamic modeling of complex systems

    DEFF Research Database (Denmark)

    Liang, Xiaodong

    after an oil spill. Engineering thermodynamics could be applied in the state-of-the-art sonar products through advanced artificial technology, if the speed of sound, solubility and density of oil-seawater systems could be satisfactorily modelled. The addition of methanol or glycols into unprocessed well...... streams during subsea pipelines is necessary to inhibit gas hydrate formation, and the offshore reservoirs often mean complicated temperature and pressure conditions. Accurate description of the phase behavior and thermalphysical properties of complex systems containing petroleum fluids and polar...... for derivative properties, e.g. speed of sound, and for density under extreme conditions. This PhD thesis studies the capabilities and limitations of the Perturbed-Chain Statistical Association Fluid Theory (PC-SAFT) equation of state. It consists of three parts. In the first part, the PC-SAFT EOS...

  18. Interdisciplinary Symposium on Complex Systems

    CERN Document Server

    Zelinka, Ivan; Rössler, Otto

    2014-01-01

    The book you hold in your hands is the outcome of the "ISCS 2013: Interdisciplinary Symposium on Complex Systems" held at the historical capital of Bohemia as a continuation of our series of symposia in the science of complex systems. Prague, one of the most beautiful European cities, has its own beautiful genius loci. Here, a great number of important discoveries were made and many important scientists spent fruitful and creative years to leave unforgettable traces. The perhaps most significant period was the time of Rudolf II who was a great supporter of the art and the science and attracted a great number of prominent minds to Prague. This trend would continue. Tycho Brahe, Niels Henrik Abel, Johannes Kepler, Bernard Bolzano, August Cauchy Christian Doppler, Ernst Mach, Albert Einstein and many others followed developing fundamental mathematical and physical theories or expanding them. Thus in the beginning of the 17th century, Kepler formulated here the first two of his three laws of planetary motion on ...

  19. Compound Synchronization of Four Chaotic Complex Systems

    Directory of Open Access Journals (Sweden)

    Junwei Sun

    2015-01-01

    Full Text Available The chaotic complex system is designed from the start of the chaotic real system. Dynamical properties of a chaotic complex system in complex space are investigated. In this paper, a compound synchronization scheme is achieved for four chaotic complex systems. According to Lyapunov stability theory and the adaptive control method, four chaotic complex systems are considered and the corresponding controllers are designed to realize the compound synchronization scheme. Four novel design chaotic complex systems are given as an example to verify the validity and feasibility of the proposed control scheme.

  20. SORTA: a system for ontology-based re-coding and technical annotation of biomedical phenotype data

    OpenAIRE

    Pang, Chao; Sollie, Annet; Sijtsma, Anna; Hendriksen, Dennis; Charbon, Bart; Haan, Mark de; de Boer, Tommy; Kelpin, Fleur; Jetten, Jonathan; van der Velde, Joeri K; Smidt, Nynke; Sijmons, Rolf; Hillege, Hans; Swertz, Morris A.

    2015-01-01

    There is an urgent need to standardize the semantics of biomedical data values, such as phenotypes, to enable comparative and integrative analyses. However, it is unlikely that all studies will use the same data collection protocols. As a result, retrospective standardization is often required, which involves matching of original (unstructured or locally coded) data to widely used coding or ontology systems such as SNOMED CT (clinical terms), ICD-10 (International Classification of Disease) a...

  1. Customizable Electronic Laboratory Online (CELO): A Web-based Data Management System Builder for Biomedical Research Laboratories

    OpenAIRE

    Fong, Christine; Brinkley, James F.

    2006-01-01

    A common challenge among today’s biomedical research labs is managing growing amounts of research data. In order to reduce the time and resource costs of building data management tools, we designed the Customizable Electronic Laboratory Online (CELO) system. CELO automatically creates a generic database and web interface for laboratories that submit a simple web registration form. Laboratories can then use a collection of predefined XML templates to assist with the design of a database schema...

  2. Lessons Learned from Development of De-identification System for Biomedical Research in a Korean Tertiary Hospital

    OpenAIRE

    Shin, Soo-Yong; Lyu, Yongman; Shin, Yongdon; Choi, Hyo Joung; Park, Jihyun; Kim, Woo-Sung; Lee, Jae Ho

    2013-01-01

    Objectives The Korean government has enacted two laws, namely, the Personal Information Protection Act and the Bioethics and Safety Act to prevent the unauthorized use of medical information. To protect patients' privacy by complying with governmental regulations and improve the convenience of research, Asan Medical Center has been developing a de-identification system for biomedical research. Methods We reviewed Korean regulations to define the scope of the de-identification methods and well...

  3. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 6, is a collection of papers that discusses the role of integrated electronics in medical systems and the usage of biological mathematical models in biological systems. Other papers deal with the health care systems, the problems and methods of approach toward rehabilitation, as well as the future of biomedical engineering. One paper discusses the use of system identification as it applies to biological systems to estimate the values of a number of parameters (for example, resistance, diffusion coefficients) by indirect means. More particularly, the i

  4. Biomedical photonics handbook biomedical diagnostics

    CERN Document Server

    Vo-Dinh, Tuan

    2014-01-01

    Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, studen

  5. Infinite Particle Systems: Complex Systems III

    Directory of Open Access Journals (Sweden)

    Editorial Board

    2008-06-01

    Full Text Available In the years 2002-2005, a group of German and Polish mathematicians worked under a DFG research project No 436 POL 113/98/0-1 entitled "Methods of stochastic analysis in the theory of collective phenomena: Gibbs states and statistical hydrodynamics". The results of their study were summarized at the German-Polish conference, which took place in Poland in October 2005. The venue of the conference was Kazimierz Dolny upon Vistula - a lovely town and a popular place for various cultural, scientific, and even political events of an international significance. The conference was also attended by scientists from France, Italy, Portugal, UK, Ukraine, and USA, which predetermined its international character. Since that time, the conference, entitled "Infinite Particle Systems: Complex Systems" has become an annual international event, attended by leading scientists from Germany, Poland and many other countries. The present volume of the "Condensed Matter Physics" contains proceedings of the conference "Infinite Particle Systems: Complex Systems III", which took place in June 2007.

  6. Metal ion-assisted self-assembly of complexes for controlled and sustained release of minocycline for biomedical applications

    International Nuclear Information System (INIS)

    This study reports the development of novel drug delivery complexes self-assembled by divalent metal ion-assisted coacervation for controlled and sustained release of a hydrophilic small drug molecule minocycline hydrochloride (MH). MH is a multifaceted agent that has demonstrated therapeutic effects in infection, inflammation, tumor, as well as cardiovascular, renal, and neurological disorders due to its anti-microbial, anti-inflammatory, and cytoprotective properties. However, the inability to translate the high doses used in experimental animals to tolerable doses in human patients limits its clinical application. Localized delivery can potentially expose the diseased tissue to high concentrations of MH that systemic delivery cannot achieve, while minimizing the side effects from systemic exposure. The strong metal ion binding-assisted interaction enabled high drug entrapment and loading efficiency, and stable long term release for more than 71 d. Released MH demonstrated potent anti-biofilm, anti-inflammatory, and neuroprotective activities. Furthermore, MH release from the complexes is pH-sensitive as the chelation between minocycline and metal ions decreases with pH, allowing ‘smart’ drug release in response to the severity of pathology-induced tissue acidosis. This novel metal ion binding-mediated drug delivery mechanism can potentially be applied to other drugs that have high binding affinity for metal ions and may lead to the development of new delivery systems for a variety of drugs. (paper)

  7. Nonlinear Waves in Complex Systems

    DEFF Research Database (Denmark)

    2007-01-01

    The study of nonlinear waves has exploded due to the combination of analysis and computations, since the discovery of the famous recurrence phenomenon on a chain of nonlinearly coupled oscillators by Fermi-Pasta-Ulam fifty years ago. More than the discovery of new integrable equations, it is the ......The study of nonlinear waves has exploded due to the combination of analysis and computations, since the discovery of the famous recurrence phenomenon on a chain of nonlinearly coupled oscillators by Fermi-Pasta-Ulam fifty years ago. More than the discovery of new integrable equations......, it is the universality and robustness of the main models with respect to perturbations that developped the field. This is true for both continuous and discrete equations. In this volume we keep this broad view and draw new perspectives for nonlinear waves in complex systems. In particular we address energy flow...

  8. Multilevel Complex Networks and Systems

    Science.gov (United States)

    Caldarelli, Guido

    2014-03-01

    Network theory has been a powerful tool to model isolated complex systems. However, the classical approach does not take into account the interactions often present among different systems. Hence, the scientific community is nowadays concentrating the efforts on the foundations of new mathematical tools for understanding what happens when multiple networks interact. The case of economic and financial networks represents a paramount example of multilevel networks. In the case of trade, trade among countries the different levels can be described by the different granularity of the trading relations. Indeed, we have now data from the scale of consumers to that of the country level. In the case of financial institutions, we have a variety of levels at the same scale. For example one bank can appear in the interbank networks, ownership network and cds networks in which the same institution can take place. In both cases the systemically important vertices need to be determined by different procedures of centrality definition and community detection. In this talk I will present some specific cases of study related to these topics and present the regularities found. Acknowledged support from EU FET Project ``Multiplex'' 317532.

  9. Increase of Organization in Complex Systems

    OpenAIRE

    Georgiev, Georgi Yordanov; Daly, Michael; Gombos, Erin; Vinod, Amrit; Hoonjan, Gajinder

    2013-01-01

    Measures of complexity and entropy have not converged to a single quantitative description of levels of organization of complex systems. The need for such a measure is increasingly necessary in all disciplines studying complex systems. To address this problem, starting from the most fundamental principle in Physics, here a new measure for quantity of organization and rate of self-organization in complex systems based on the principle of least (stationary) action is applied to a model system -...

  10. Extending Life Concepts to Complex Systems

    OpenAIRE

    Jean Le Fur

    2013-01-01

    There is still no consensus definition of complex systems. This article explores, as a heuristic approach, the possibility of using notions associated with life as transversal concepts for defining complex systems. This approach is developed within a general classification of systems, with complex systems considered as a general ‘living things’ category and living organisms as a specialised class within this category. Concepts associated with life are first explored in the context of complex ...

  11. Biomedical technology transfer: Bioinstrumentation for cardiology, neurology, and the circulatory system

    Science.gov (United States)

    1976-01-01

    Developments in applying aerospace medical technology to the design and production of medical equipment and instrumentation are reported. Projects described include intercranial pressure transducers, leg negative pressure devices, a synthetic speech prosthesis for victims of cerebral palsy, and a Doppler blood flow instrument. Commercialization activities for disseminating and utilizing NASA technology, and new biomedical problem areas are discussed.

  12. Cooperative behaviour in complex systems

    Science.gov (United States)

    Karsai, Márton

    2009-07-01

    In my PhD thesis I studied cooperative phenomena arise in complex systems using the methods of statistical and computational physics. The aim of my work was also to study the critical behaviour of interacting many-body systems during their phase transitions and describe their universal features analytically and by means of numerical calculations. In order to do so I completed studies in four different subjects. My first investigated subject was a study of non-equilibrium phase transitions in weighted scale-free networks. The second problem I examined was the ferromagnetic random bond Potts model with large values of q on evolving scale-free networks which problem is equivalent to an optimal cooperation problem. The third examined problem was related to the large-q sate random bond Potts model also and I examined the critical density of clusters which touched a certain border of a perpendicular strip like geometry and expected to hold analytical forms deduced from conformal invariance. The last investigated problem was a study of the non-equilibrium dynamical behaviour of the antiferromagnetic Ising model on two-dimensional triangular lattice at zero temperature in the absence of external field and at the Kosterlitz-Thouless phase transition point.

  13. Metasynthetic computing and engineering of complex systems

    CERN Document Server

    Cao, Longbing

    2015-01-01

    Provides a comprehensive overview and introduction to the concepts, methodologies, analysis, design and applications of metasynthetic computing and engineering. The author: Presents an overview of complex systems, especially open complex giant systems such as the Internet, complex behavioural and social problems, and actionable knowledge discovery and delivery in the big data era. Discusses ubiquitous intelligence in complex systems, including human intelligence, domain intelligence, social intelligence, network intelligence, data intelligence and machine intelligence, and their synergy thro

  14. Hierarchical Self-organization of Complex Systems

    Institute of Scientific and Technical Information of China (English)

    CHAI Li-he; WEN Dong-sheng

    2004-01-01

    Researches on organization and structure in complex systems are academic and industrial fronts in modern sciences. Though many theories are tentatively proposed to analyze complex systems, we still lack a rigorous theory on them. Complex systems possess various degrees of freedom, which means that they should exhibit all kinds of structures. However, complex systems often show similar patterns and structures. Then the question arises why such similar structures appear in all kinds of complex systems. The paper outlines a theory on freedom degree compression and the existence of hierarchical self-organization for all complex systems is found. It is freedom degree compression and hierarchical self-organization that are responsible for the existence of these similar patterns or structures observed in the complex systems.

  15. Complex system modelling and control through intelligent soft computations

    CERN Document Server

    Azar, Ahmad

    2015-01-01

    The book offers a snapshot of the theories and applications of soft computing in the area of complex systems modeling and control. It presents the most important findings discussed during the 5th International Conference on Modelling, Identification and Control, held in Cairo, from August 31-September 2, 2013. The book consists of twenty-nine selected contributions, which have been thoroughly reviewed and extended before their inclusion in the volume. The different chapters, written by active researchers in the field, report on both current theories and important applications of soft-computing. Besides providing the readers with soft-computing fundamentals, and soft-computing based inductive methodologies/algorithms, the book also discusses key industrial soft-computing applications, as well as multidisciplinary solutions developed for a variety of purposes, like windup control, waste management, security issues, biomedical applications and many others. It is a perfect reference guide for graduate students, r...

  16. Encyclopedia of Complexity and Systems Science

    CERN Document Server

    Meyers, Robert A

    2009-01-01

    Encyclopedia of Complexity and Systems Science provides an authoritative single source for understanding and applying the concepts of complexity theory together with the tools and measures for analyzing complex systems in all fields of science and engineering. The science and tools of complexity and systems science include theories of self-organization, complex systems, synergetics, dynamical systems, turbulence, catastrophes, instabilities, nonlinearity, stochastic processes, chaos, neural networks, cellular automata, adaptive systems, and genetic algorithms. Examples of near-term problems and major unknowns that can be approached through complexity and systems science include: The structure, history and future of the universe; the biological basis of consciousness; the integration of genomics, proteomics and bioinformatics as systems biology; human longevity limits; the limits of computing; sustainability of life on earth; predictability, dynamics and extent of earthquakes, hurricanes, tsunamis, and other n...

  17. A novel multisensoric system recording and analyzing human biometric features for biometric and biomedical applications

    OpenAIRE

    Bashir, Muzaffar

    2012-01-01

    The recording and analyzing human motor control movements are fundamental parts of both behavioral biometrics and biomedical research studies. The dynamics of human motor functions of fingers, hand and wrist movements can be studied while handwriting, drawing or hand gestures. The major difficulties are the acquisition of high quality data and the characterization of the acquired data accurately and efficiently. A multisensoric Biometric Smart Pen BiSP device has been developed which has the ...

  18. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1976-01-01

    Advances in Biomedical Engineering, Volume 5, is a collection of papers that deals with application of the principles and practices of engineering to basic and applied biomedical research, development, and the delivery of health care. The papers also describe breakthroughs in health improvements, as well as basic research that have been accomplished through clinical applications. One paper examines engineering principles and practices that can be applied in developing therapeutic systems by a controlled delivery system in drug dosage. Another paper examines the physiological and materials vari

  19. Complex systems in metabolic engineering.

    Science.gov (United States)

    Winkler, James D; Erickson, Keesha; Choudhury, Alaksh; Halweg-Edwards, Andrea L; Gill, Ryan T

    2015-12-01

    Metabolic engineers manipulate intricate biological networks to build efficient biological machines. The inherent complexity of this task, derived from the extensive and often unknown interconnectivity between and within these networks, often prevents researchers from achieving desired performance. Other fields have developed methods to tackle the issue of complexity for their unique subset of engineering problems, but to date, there has not been extensive and comprehensive examination of how metabolic engineers use existing tools to ameliorate this effect on their own research projects. In this review, we examine how complexity affects engineering at the protein, pathway, and genome levels within an organism, and the tools for handling these issues to achieve high-performing strain designs. Quantitative complexity metrics and their applications to metabolic engineering versus traditional engineering fields are also discussed. We conclude by predicting how metabolic engineering practices may advance in light of an explicit consideration of design complexity. PMID:26319897

  20. European Conference on Complex Systems 2012

    CERN Document Server

    Kirkilionis, Markus; Nicolis, Gregoire

    2013-01-01

    The European Conference on Complex Systems, held under the patronage of the Complex Systems Society, is an annual event that has become the leading European conference devoted to complexity science. ECCS'12, its ninth edition, took place in Brussels, during the first week of September 2012. It gathered about 650 scholars representing a wide range of topics relating to complex systems research, with emphasis on interdisciplinary approaches. More specifically, the following tracks were covered:  1. Foundations of Complex Systems 2. Complexity, Information and Computation 3. Prediction, Policy and Planning, Environment 4. Biological Complexity 5. Interacting Populations, Collective Behavior 6. Social Systems, Economics and Finance This book contains a selection of the contributions presented at the conference and its satellite meetings. Its contents reflect the extent, diversity and richness of research areas in the field, both fundamental and applied.  

  1. Systemic Resilience of Complex Urban Systems

    Directory of Open Access Journals (Sweden)

    Serge Salat

    2012-07-01

    Full Text Available Two key paradigms emerge out of the variety of urban forms: certain cities resemble trees, others leaves. The structural difference between a tree and a leaf is huge: one is open, the other closed. Trees are entirely disconnected on a given scale: even if two twigs are spatially close, if they do not belong to the same branch, to go from one to the other implies moving down and then up all the hierarchy of branches.  Leaves on the contrary are entirely connected on intermediary scales. The veins of a leaf are disconnected on the two larger scales but entirely connected on the two or three following intermediary scales before presenting tiny tree-like structures on the finest capillary scales. Deltas are leaves not trees. Neither galaxies nor whirlpools are trees. We will see in this paper that historical cities, like leaves, deltas, galaxies, lungs, brains and vein systems are all fractal structures, multiply connected and complex on all scales. These structures display the same degree of complexity and connectivity, regardless of the magnification scale on which we observe them. We say that these structures are scale free. Mathematical fractal forms are often generated recursively by applying again and again the same generator to an initiator. The iteration creates an arborescence. But scale free structure is not synonymous with a recursive tree-like structure. The fractal structure of the leaf is much more complex than that of the tree by its multiconnectivity on three or more intermediary levels. In contrast, trees in the virgin forest, even when they seem to be entangled, horizontal, and rhizomic, have branches that are not interconnected to form a lattice. As we will see, the history of urban planning has evolved from leaf-like to tree-like patterns, with a consequent loss of efficiency and resilience. Indeed, in a closed foliar path structure, the formation of cycles enables internal complexification and flow fluctuations due to the

  2. Synchronization and emergence in complex systems

    Indian Academy of Sciences (India)

    Fatihcan M Atay

    2011-11-01

    We show how novel behaviour can emerge in complex systems at the global level through synchronization of the activities of their constituent units. Two mechanisms are suggested for the emergence, namely non-diffusive coupling and time delays. In this way, simple units can synchronize to display complex dynamics, or conversely, simple dynamics may arise from complex constituents.

  3. COMPLEX COMPOST AND DETOXICATION OF AGROLANDSCAPE SYSTEMS

    Directory of Open Access Journals (Sweden)

    Belyuchenko I. S.

    2014-03-01

    Full Text Available Toxicity complex compost arises during compiling of organomineral mixtures of various waste of life, agriculture and mineral industries. One of detoxification factors of complex compost is the ability of heavy metal cations to the formation insoluble compounds, which are fixed by clay materials and different disperse systems, and differ markedly by calcium content, acidity and humus soil-absorbing complex

  4. Extending Life Concepts to Complex Systems

    Directory of Open Access Journals (Sweden)

    Jean Le Fur

    2013-01-01

    Full Text Available There is still no consensus definition of complex systems. This article explores, as a heuristic approach, the possibility of using notions associated with life as transversal concepts for defining complex systems. This approach is developed within a general classification of systems, with complex systems considered as a general ‘living things’ category and living organisms as a specialised class within this category. Concepts associated with life are first explored in the context of complex systems: birth, death and lifetime, adaptation, ontogeny and growth, reproduction. Thereafter, a refutation approach is used to test the proposed classification against a set of diverse systems, including a reference case, edge cases and immaterial complex systems. The summary of this analysis is then used to generate a definition of complex systems, based on the proposal, and within the background of cybernetics, complex adaptive systems and biology. Using notions such as ‘birth’ or ‘lifespan’ as transversal concepts may be of heuristic value for the generic characterization of complex systems, opening up new lines of research for improving their definition.

  5. Bevalac biomedical facility

    International Nuclear Information System (INIS)

    This paper describes the physical layout of the Bevalac Facility and the research programs carried out at the facility. Beam time on the Bevalac is divided between two disciplines: one-third for biomedical research and two-thirds for nuclear science studies. The remainder of the paper discusses the beam delivery system including dosimetry, beam sharing and beam scanning

  6. Predictive Approaches to Control of Complex Systems

    CERN Document Server

    Karer, Gorazd

    2013-01-01

    A predictive control algorithm uses a model of the controlled system to predict the system behavior for various input scenarios and determines the most appropriate inputs accordingly. Predictive controllers are suitable for a wide range of systems; therefore, their advantages are especially evident when dealing with relatively complex systems, such as nonlinear, constrained, hybrid, multivariate systems etc. However, designing a predictive control strategy for a complex system is generally a difficult task, because all relevant dynamical phenomena have to be considered. Establishing a suitable model of the system is an essential part of predictive control design. Classic modeling and identification approaches based on linear-systems theory are generally inappropriate for complex systems; hence, models that are able to appropriately consider complex dynamical properties have to be employed in a predictive control algorithm. This book first introduces some modeling frameworks, which can encompass the most frequ...

  7. The 1 MV multi-element AMS system for biomedical applications at the Netherlands Organization for Applied Scientific Research (TNO)

    International Nuclear Information System (INIS)

    The Netherlands Organization for Applied Scientific Research (TNO) has installed a compact 1 MV multi-element AMS system manufactured by High Voltage Engineering Europa B.V., The Netherlands. TNO performs clinical research programs for pharmaceutical and innovative foods industry to obtain early pharmacokinetic data and to provide anti-osteoporotic efficacy data of new treatments. The AMS system will analyze carbon, iodine and calcium samples for this purpose. The first measurements on blank samples indicate background levels in the low 10−12 for calcium and iodine, making the system well suited for these biomedical applications. Carbon blanks have been measured at low 10−16. For unattended, around-the-clock analysis, the system features the 200 sample version of the SO110 hybrid ion source and user friendly control software.

  8. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains over 35 papers selected from those presented at the conference on topics including: self-organization in biology, ecological systems, language, economic modeling, ecological systems, artificial life, robotics, and complexity and art. ALI MINAI is an Affiliate of the New England Complex Systems Institute and an Associate Professor in the Department of Electrical and Computer Engine...

  9. Reliability of large and complex systems

    CERN Document Server

    Kolowrocki, Krzysztof

    2014-01-01

    Reliability of Large and Complex Systems, previously titled Reliability of Large Systems, is an innovative guide to the current state and reliability of large and complex systems. In addition to revised and updated content on the complexity and safety of large and complex mechanisms, this new edition looks at the reliability of nanosystems, a key research topic in nanotechnology science. The author discusses the importance of safety investigation of critical infrastructures that have aged or have been exposed to varying operational conditions. This reference provides an asympt

  10. Reliability calculations for complex systems

    OpenAIRE

    Lenz, Malte; Rhodin, Johan

    2011-01-01

    Functionality for efficient computation of properties of system lifetimes was developed, based on the Mathematica framework. The model of these systems consists of a system structure and the components independent lifetime distributions. The components are assumed to be non-repairable. In this work a very general implementation was created, allowing a large number of lifetime distributions from Mathematica for all the component distributions. All system structures with a monotone increasing s...

  11. Theoretical studies to elucidate the influence of magnetic dipolar interactions occurring in the magnetic nanoparticle systems, for biomedical applications

    Science.gov (United States)

    Osaci, M.; Cacciola, M.

    2016-02-01

    In recent years, the study of magnetic nanoparticles has been intensively developed not only for their fundamental theoretical interest, but also for their many technological applications, especially biomedical applications, ranging from contrast agents for magnetic resonance imaging to the deterioration of cancer cells via hyperthermia treatment. The theoretical and experimental research has shown until now that the magnetic dipolar interactions between nanoparticles can have a significant influence on the magnetic behaviour of the system. But, this influence is not well understood. It is clear that the magnetic dipolar interaction intensity is correlated with the nanoparticle concentration, volume fraction and magnetic moment orientations. In this paper, we try to understand the influence of magnetic dipolar interactions on the behaviour of magnetic nanoparticle systems, for biomedical applications. For the model, we considered spherical nanoparticles with uniaxial anisotropy and lognormal distribution of the sizes. The model involves a simulation stage of the spatial distribution and orientation of the nanoparticles and their easy axes of magnetic anisotropy, and an evaluation stage of the Néel relaxation time. To assess the Néel relaxation time, we are going to discretise and adapt, to the local magnetic field, the Coffey analytical solution for the equation Fokker-Planck describing the dynamics of magnetic moments of nanoparticles in oblique external magnetic field. There are three fundamental aspects of interest in our studies on the magnetic nanoparticles: their spatial & orientational distributions, concentrations and sizes.

  12. Self-Organization of Complex Systems

    OpenAIRE

    Paczuski, Maya; Bak, Per

    1999-01-01

    The basic laws of physics are simple, so why is the world complex? The theory of self-organized criticality posits that complex behavior in nature emerges from the dynamics of extended, dissipative systems that evolve through a sequence of meta-stable states into a critical state, with long range spatial and temporal correlations. Minor disturbances lead to intermittent events of all sizes. These events organize the system into a complex state that cannot be reduced to a few degrees of freedo...

  13. The challenge of complexity for cognitive systems

    OpenAIRE

    Schmid, Ute; Funke, Joachim et al.

    2011-01-01

    Complex cognition addresses research on (a) high-level cognitive processes – mainly problem solving, reasoning, and decision making – and their interaction with more basic processes such as perception, learning, motivation and emotion and (b) cognitive processes which take place in a complex, typically dynamic, environment. Our focus is on AI systems and cognitive models dealing with complexity and on psychological findings which can inspire or challenge cognitive systems research. In this...

  14. The challenge of complexity for cognitive systems

    OpenAIRE

    Schmid, Ute; Ragni, Marco; Gonzalez, Cleotilde; Funke, Joachim

    2011-01-01

    Complex cognition addresses research on (a) high-level cognitive processes – mainly problem solving, reasoning, and decision making – and their interaction with more basic processes such as perception, learning, motivation and emotion and (b) cognitive processes which take place in a complex, typically dynamic, environment. Our focus is on AI systems and cognitive models dealing with complexity and on psychological findings which can inspire or challenge cognitive systems research. In this ov...

  15. About Evaluation of Complex Dynamical Systems

    OpenAIRE

    Dmytro Polishchuk; Olexandr Polishchuk

    2016-01-01

    The methods are proposed for evaluation of complex dynamical systems, choice of their optimal operating modes, determination of optimal operating system from given class of equivalent systems, system's timeline behaviour analysis on the basis of versatile multicriteria and multilevel analysis of behaviour of system's elements.

  16. Mining sensor data from complex systems

    NARCIS (Netherlands)

    Vespier, Ugo

    2015-01-01

    Today, virtually everything, from natural phenomena to complex artificial and physical systems, can be measured and the resulting information collected, stored and analyzed in order to gain new insight. This thesis shows how complex systems often exhibit diverse behavior at different temporal scales

  17. Complex Evaluation of Hierarchically-Network Systems

    CERN Document Server

    Polishchuk, Dmytro; Yadzhak, Mykhailo

    2016-01-01

    Methods of complex evaluation based on local, forecasting, aggregated, and interactive evaluation of the state, function quality, and interaction of complex system's objects on the all hierarchical levels is proposed. Examples of analysis of the structural elements of railway transport system are used for illustration of efficiency of proposed approach.

  18. Conceptual Modelling of Complex Production Systems

    OpenAIRE

    Nenad Perši

    2008-01-01

    Complex system dynamics, structure and behaviour performances call for a wide range of methods, algorithms and tools to reach a model capable of finding optimal performing parameters. In the modelling process, it is up to the analyst to select the appropriate combination of methods, algorithms and tools to express significant system performances. Such a methodology for designing complex systems should be based upon conceptual modelling to perform a sensitive analysis of different system level...

  19. The Ontologies of Complexity and Learning about Complex Systems

    Science.gov (United States)

    Jacobson, Michael J.; Kapur, Manu; So, Hyo-Jeong; Lee, June

    2011-01-01

    This paper discusses a study of students learning core conceptual perspectives from recent scientific research on complexity using a hypermedia learning environment in which different types of scaffolding were provided. Three comparison groups used a hypermedia system with agent-based models and scaffolds for problem-based learning activities that…

  20. Biomedical irradiation system for boron neutron capture therapy at the Kyoto University reactor

    International Nuclear Information System (INIS)

    Physics studies related to radiation source, spectroscopy, beam quality, dosimetry, and biomedical applications using the Kyoto University Reactor Heavy Water Facility are described. Also, described are a Nickel Mirror Neutron Guide Tube and a Super Mirror Neutron Guide Tube that are used both for the measurement of boron concentration in phantom and living tissue and for precise measurements of neutron flux in phantom in the presence of both light and heavy water. Discussed are: (1) spectrum measurements using the time of flight technique, (2) the elimination of gamma rays and fast neutrons from a thermal neutron irradiation field, (3) neutron collimation without producing secondary gamma rays, (4) precise neutron flux measurements, dose estimation, and the measurement of boron concentration in tumor and its periphery using guide tubes, (5) the dose estimation of boron-10 for the first melanoma patient, and (6) special-purpose biological irradiation equipment. Other related subjects are also described

  1. Fourth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems IV

    2008-01-01

    In June of 2002, over 500 professors, students and researchers met in Boston, Massachusetts for the Fourth International Conference on Complex Systems. The attendees represented a remarkably diverse collection of fields: biology, ecology, physics, engineering, computer science, economics, psychology and sociology, The goal of the conference was to encourage cross-fertilization between the many disciplines represented and to deepen understanding of the properties common to all complex systems. This volume contains 43 papers selected from the more than 200 presented at the conference. Topics include: cellular automata, neurology, evolution, computer science, network dynamics, and urban planning. About NECSI: For over 10 years, The New England Complex Systems Institute (NECSI) has been instrumental in the development of complex systems science and its applications. NECSI conducts research, education, knowledge dissemination, and community development around the world for the promotion of the study of complex sys...

  2. Sixth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali; Bar-Yam, Yaneer; Unifying Themes in Complex Systems

    2008-01-01

    The International Conference on Complex Systems (ICCS) creates a unique atmosphere for scientists of all fields, engineers, physicians, executives, and a host of other professionals to explore the common themes and applications of complex systems science. In June 2006, 500 participants convened in Boston for the sixth ICCS, exploring an array of topics, including networks, systems biology, evolution and ecology, nonlinear dynamics and pattern formation, as well as neural, psychological, psycho-social, socio-economic, and global systems. This volume selects 77 papers from over 300 presented at the conference. With this new volume, Unifying Themes in Complex Systems continues to build common ground between the wide-ranging domains of complex systems science.

  3. Models of complex attitude systems

    DEFF Research Database (Denmark)

    Sørensen, Bjarne Taulo

    production systems was modelled. The analysis was based on data from a cross-cultural survey involving 1931 participants from Belgium, Denmark, Germany and Poland. The survey questionnaire contained measures of personal value orientations and attitudes towards environment and nature, industrial food...... production, food and the environment, technological progress, animal welfare, local employment and the local economy. In addition, the survey included a conjoint task by which participants’ evaluations of the importance of production system attributes were measured. The data were analysed by means of causal...

  4. Detection of timescales in evolving complex systems

    CERN Document Server

    Darst, Richard K; Arenas, Alex; Gómez, Sergio; Saramäki, Jari; Fortunato, Santo

    2016-01-01

    Most complex systems are intrinsically dynamic in nature. The evolution of a dynamic complex system is typically represented as a sequence of snapshots, where each snapshot describes the configuration of the system at a particular instant of time. Then, one may directly follow how the snapshots evolve in time, or aggregate the snapshots within some time intervals to form representative "slices" of the evolution of the system configuration. This is often done with constant intervals, whose duration is based on arguments on the nature of the system and of its dynamics. A more refined approach would be to consider the rate of activity in the system to perform a separation of timescales. However, an even better alternative would be to define dynamic intervals that match the evolution of the system's configuration. To this end, we propose a method that aims at detecting evolutionary changes in the configuration of a complex system, and generates intervals accordingly. We show that evolutionary timescales can be id...

  5. Systems pharmacology of complex diseases

    OpenAIRE

    Hansen, Jens; Zhao, Shan; Iyengar, Ravi

    2011-01-01

    Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.

  6. Simple molecules as complex systems.

    Science.gov (United States)

    Furtenbacher, Tibor; Arendás, Péter; Mellau, Georg; Császár, Attila G

    2014-01-01

    For individual molecules quantum mechanics (QM) offers a simple, natural and elegant way to build large-scale complex networks: quantized energy levels are the nodes, allowed transitions among the levels are the links, and transition intensities supply the weights. QM networks are intrinsic properties of molecules and they are characterized experimentally via spectroscopy; thus, realizations of QM networks are called spectroscopic networks (SN). As demonstrated for the rovibrational states of H2(16)O, the molecule governing the greenhouse effect on earth through hundreds of millions of its spectroscopic transitions (links), both the measured and first-principles computed one-photon absorption SNs containing experimentally accessible transitions appear to have heavy-tailed degree distributions. The proposed novel view of high-resolution spectroscopy and the observed degree distributions have important implications: appearance of a core of highly interconnected hubs among the nodes, a generally disassortative connection preference, considerable robustness and error tolerance, and an "ultra-small-world" property. The network-theoretical view of spectroscopy offers a data reduction facility via a minimum-weight spanning tree approach, which can assist high-resolution spectroscopists to improve the efficiency of the assignment of their measured spectra. PMID:24722221

  7. Chaotic systems in complex phase space

    Indian Academy of Sciences (India)

    Carl M Bender; Joshua Feinberg; Daniel W Hook; David J Weir

    2009-09-01

    This paper examines numerically the complex classical trajectories of the kicked rotor and the double pendulum. Both of these systems exhibit a transition to chaos, and this feature is studied in complex phase space. Additionally, it is shown that the short-time and long-time behaviours of these two $\\mathcal{PT}$ -symmetric dynamical models in complex phase space exhibit strong qualitative similarities.

  8. Complex motions and chaos in nonlinear systems

    CERN Document Server

    Machado, José; Zhang, Jiazhong

    2016-01-01

    This book brings together 10 chapters on a new stream of research examining complex phenomena in nonlinear systems—including engineering, physics, and social science. Complex Motions and Chaos in Nonlinear Systems provides readers a particular vantage of the nature and nonlinear phenomena in nonlinear dynamics that can develop the corresponding mathematical theory and apply nonlinear design to practical engineering as well as the study of other complex phenomena including those investigated within social science.

  9. Understanding Complex Construction Systems Through Modularity

    DEFF Research Database (Denmark)

    Jensen, Tor Clarke; Bekdik, Baris; Thuesen, Christian

    This paper develops a framework for understanding complexity in construction projects by combining theories of complexity management and modularization. The framework incorporates three dimensions of product, process, and organizational modularity with the case of gypsum wall elements. The analysis...... system, rather than a modular, although the industry forces modular organizational structures. This creates a high complexity degree caused by the non-alignment of building parts and organizations and the frequent swapping of modules....

  10. Dynamics of complex quantum systems

    CERN Document Server

    Akulin, Vladimir M

    2014-01-01

    This book gathers together a range of similar problems that can be encountered in different fields of modern quantum physics and that have common features with regard to multilevel quantum systems. The main motivation was to examine from a uniform standpoint various models and approaches that have been developed in atomic, molecular, condensed matter, chemical, laser and nuclear physics in various contexts. The book should help senior-level undergraduate, graduate students and researchers putting particular problems in these fields into a broader scientific context and thereby taking advantage of well-established techniques used in adjacent fields. This second edition has been expanded to include substantial new material (e.g. new sections on Dynamic Localization and on Euclidean Random Matrices and new chapters on Entanglement, Open Quantum Systems, and Coherence Protection). It is based on the author’s lectures at the Moscow Institute of Physics and Technology, at the CNRS Aimé Cotton Laboratory, and on ...

  11. Three sided complex adaptative systems

    CERN Document Server

    D'Hulst, R

    1999-01-01

    We introduce two three sided adaptative systems as toy models to mimic the exchange of commodities between buyers and sellers. These models are simple extensions of the minority game, exhibiting similar behaviour as well as some new features. The main difference between our two models is that in the first the three sides are equivalent while in the second, one choice appears as a compromise between the two other sides. Both models are investigated numerically and compared with the original minority game.

  12. Understanding Complex Adaptive Systems by Playing Games

    Directory of Open Access Journals (Sweden)

    Igor MAYER

    2010-04-01

    Full Text Available While educators teach their students about decision making in complex environments, managers have to deal with the complexity of large projects on a daily basis. To make better decisions it is assumed, that the latter would benefit from better understanding of complex phenomena, as do students as the professionals of the future. The goal of this article is to evaluate the relevance of the use of simulation games for learning about the complexity of large-scale socio-technical projects. Relevant concepts from complex adaptive systems will be introduced or described. The conjecture is that complex adaptive systems can be simulated by games, in which players are able to experience the system workings, and retrieve more insight in their complex behaviour as a result. The multiplayer computer game SimPort-MV2 illustrates this by simulating the decision making process revolving around Maasvlakte 2 (MV2, an extension of the Port of Rotterdam into the North Sea. The game has been played by hundreds of students of higher education. Based on this study, we present preliminary indications of learning and conclusions on how simulation games can provide insights in a complex adaptive system and be used to educate both students and professionals.

  13. Complex engineering systems science meets technology

    CERN Document Server

    Minai, Ali A; Bar-Yam, Yaneer

    2006-01-01

    Every time that we take money out of an ATM, surf the internet or simply turn on a light switch, we enjoy the benefits of complex engineered systems. Systems like power grids and global communication networks are so ubiquitous in our daily lives that we usually take them for granted, only noticing them when they break down. But how do such amazing technologies and infrastructures come to be what they are? How are these systems designed? How do distributed networks work? How are they made to respond rapidly in 'real time'? And as the demands that we place on these systems become increasingly complex, are traditional systems-engineering practices still relevant? This volume examines the difficulties that arise in creating highly complex engineered systems and new approaches that are being adopted. Topics addressed range from the formal representation and classification of distributed networked systems to revolutionary engineering practices inspired by biological evolution. By bringing together the latest resear...

  14. Geographical National Condition and Complex System

    Directory of Open Access Journals (Sweden)

    WANG Jiayao

    2016-01-01

    Full Text Available The significance of studying the complex system of geographical national conditions lies in rationally expressing the complex relationships of the “resources-environment-ecology-economy-society” system. Aiming to the problems faced by the statistical analysis of geographical national conditions, including the disunity of research contents, the inconsistency of range, the uncertainty of goals, etc.the present paper conducted a range of discussions from the perspectives of concept, theory and method, and designed some solutions based on the complex system theory and coordination degree analysis methods.By analyzing the concepts of geographical national conditions, geographical national conditions survey and geographical national conditions statistical analysis, as well as investigating the relationships between theirs, the statistical contents and the analytical range of geographical national conditions are clarified and defined. This investigation also clarifies the goals of the statistical analysis by analyzing the basic characteristics of the geographical national conditions and the complex system, and the consistency between the analysis of the degree of coordination and statistical analyses. It outlines their goals, proposes a concept for the complex system of geographical national conditions, and it describes the concept. The complex system theory provides new theoretical guidance for the statistical analysis of geographical national conditions. The degree of coordination offers new approaches on how to undertake the analysis based on the measurement method and decision-making analysis scheme upon which the complex system of geographical national conditions is based. It analyzes the overall trend via the degree of coordination of the complex system on a macro level, and it determines the direction of remediation on a micro level based on the degree of coordination among various subsystems and of single systems. These results establish

  15. Increase of Organization in Complex Systems

    CERN Document Server

    Georgiev, Georgi Yordanov; Gombos, Erin; Vinod, Amrit; Hoonjan, Gajinder

    2013-01-01

    Measures of complexity and entropy have not converged to a single quantitative description of levels of organization of complex systems. The need for such a measure is increasingly necessary in all disciplines studying complex systems. To address this problem, starting from the most fundamental principle in Physics, here a new measure for quantity of organization and rate of self-organization in complex systems based on the principle of least (stationary) action is applied to a model system - the central processing unit (CPU) of computers. The quantity of organization for several generations of CPUs shows a double exponential rate of change of organization with time. The exact functional dependence has a fine, S-shaped structure, revealing some of the mechanisms of self-organization. The principle of least action helps to explain the mechanism of increase of organization through quantity accumulation and constraint and curvature minimization with an attractor, the least average sum of actions of all elements ...

  16. From System Complexity to Emergent Properties

    CERN Document Server

    Aziz-Alaoui, M. A

    2009-01-01

    Emergence and complexity refer to the appearance of higher-level properties and behaviours of a system that obviously comes from the collective dynamics of that system's components. These properties are not directly deductable from the lower-level motion of that system. Emergent properties are properties of the "whole'' that are not possessed by any of the individual parts making up that whole. Such phenomena exist in various domains and can be described, using complexity concepts and thematic knowledges. This book highlights complexity modelling through dynamical or behavioral systems. The pluridisciplinary purposes, developped along the chapters, are enable to design links between a wide-range of fundamental and applicative Sciences. Developing such links - instead of focusing on specific and narrow researches - is characteristic of the Science of Complexity that we try to promote by this contribution.

  17. Coordination Approaches for Complex Software Systems

    OpenAIRE

    Bosse, T.; Hoogendoorn, M; Treur, J.

    2006-01-01

    This document presents the results of a collaboration between the Vrije Universiteit Amsterdam, Department of Artificial Intelligence and Force Vision to investigate coordination approaches for complex software systems. The project was funded by Force Vision.

  18. Quantum mechanics in complex systems

    Science.gov (United States)

    Hoehn, Ross Douglas

    This document should be considered in its separation; there are three distinct topics contained within and three distinct chapters within the body of works. In a similar fashion, this abstract should be considered in three parts. Firstly, we explored the existence of multiply-charged atomic ions by having developed a new set of dimensional scaling equations as well as a series of relativistic augmentations to the standard dimensional scaling procedure and to the self-consistent field calculations. Secondly, we propose a novel method of predicting drug efficacy in hopes to facilitate the discovery of new small molecule therapeutics by modeling the agonist-protein system as being similar to the process of Inelastic Electron Tunneling Spectroscopy. Finally, we facilitate the instruction in basic quantum mechanical topics through the use of quantum games; this method of approach allows for the generation of exercises with the intent of conveying the fundamental concepts within a first year quantum mechanics classroom. Furthermore, no to be mentioned within the body of the text, yet presented in appendix form, certain works modeling the proliferation of cells types within the confines of man-made lattices for the purpose of facilitating artificial vascular transplants. In Chapter 2, we present a theoretical framework which describes multiply-charged atomic ions, their stability within super-intense laser fields, also lay corrections to the systems due to relativistic effects. Dimensional scaling calculations with relativistic corrections for systems: H, H-, H 2-, He, He-, He2-, He3- within super-intense laser fields were completed. Also completed were three-dimensional self consistent field calculations to verify the dimensionally scaled quantities. With the aforementioned methods the system's ability to stably bind 'additional' electrons through the development of multiple isolated regions of high potential energy leading to nodes of high electron density is shown

  19. Evolutionary Subnetworks in Complex Systems

    CERN Document Server

    Li, Menghui; Lai, Choy-Heng

    2009-01-01

    Links in a practical network may have different functions, which makes the original network a combination of some functional subnetworks. Here, by a model of coupled oscillators, we investigate how such functional subnetworks are evolved and developed according to the network structure and dynamics. In particular, we study the case of evolutionary clustered networks in which the function of each link (either attractive or repulsive coupling) is updated by the local dynamics. It is found that, during the process of system evolution, the network is gradually stabilized into a particular form in which the attractive (repulsive) subnetwork consists only the intralinks (interlinks). Based on the properties of subnetwork evolution, we also propose a new algorithm for network partition which is distinguished by the convenient operation and fast computing speed.

  20. Mining sensor data from complex systems

    OpenAIRE

    Vespier, Ugo

    2015-01-01

    Today, virtually everything, from natural phenomena to complex artificial and physical systems, can be measured and the resulting information collected, stored and analyzed in order to gain new insight. This thesis shows how complex systems often exhibit diverse behavior at different temporal scales, and that data mining methods should be able to cope with the multiple resolutions (scales) at the same time in order to fully understand the data at hand and extract useful information from it. U...

  1. Complexity in physical, living and mathematical systems

    OpenAIRE

    Lacasa Saiz de Arce, Lucas

    2009-01-01

    This thesis is in a first place a compendium of different works addressing the emer¬gence of analogous complex behavior in areas of different garment, such as Social systems, Ecology, Networks, Stochastic Algorithms or Mathematical sequences. It also proposes in a second place some new methods and methodologies for Complex systems analysis. Some material is based on seven published papers and two preprints under review whose references can be found in the Concluding section. The work is divid...

  2. Project risk management in complex petrochemical system

    Directory of Open Access Journals (Sweden)

    Kirin Snežana

    2012-01-01

    Full Text Available Investigation of risk in complex industrial systems, as well as evaluation of main factors influencing decision making and implementation process using large petrochemical company as an example, has proved the importance of successful project risk management. This is even more emphasized when analyzing systems with complex structure, i.e. with several organizational units. It has been shown that successful risk management requires modern methods, based on adequate application of statistical analysis methods.

  3. Signs, Systems and Complexity of Transmedia Storytelling

    OpenAIRE

    Renira Rampazzo Gambarato

    2012-01-01

    This article addresses key concepts such as sign, system and complexity in order to approach transmedia storytelling and better understand its intricate nature. The theoretical framework chosen to investigate transmedia storytelling meanders is Semiotics by Charles Sanders Peirce (1839-1914) and General Systems Theory by Mario Bunge (1919-). The complexity of transmedia storytelling is not simply the one of the signs of the works included in a transmedia franchise. It also includes the comple...

  4. Machine learning and complex-network for personalized and systems biomedicine

    KAUST Repository

    Cannistraci, Carlo Vittorio

    2016-01-27

    The talk will begin with an introduction on using machine learning to discover hidden information and unexpected patterns in large biomedical datasets. Then, recent results on the use of complex network theory in biomedicine and neuroscience will be discussed. In particular, metagenomics and metabolomics data, approaches for drug-target repositioning, functional/structural MR connectomes and gut-brain axis data will be presented. The conclusion will outline the novel and exciting perspectives offered by the translation of these methods from systems biology to systems medicine.

  5. Advanced Methods of Biomedical Signal Processing

    CERN Document Server

    Cerutti, Sergio

    2011-01-01

    This book grew out of the IEEE-EMBS Summer Schools on Biomedical Signal Processing, which have been held annually since 2002 to provide the participants state-of-the-art knowledge on emerging areas in biomedical engineering. Prominent experts in the areas of biomedical signal processing, biomedical data treatment, medicine, signal processing, system biology, and applied physiology introduce novel techniques and algorithms as well as their clinical or physiological applications. The book provides an overview of a compelling group of advanced biomedical signal processing techniques, such as mult

  6. Low Complex System for Levitating Ferromagnetic Materials

    Directory of Open Access Journals (Sweden)

    Dahiru Sani Shu'aibu

    2010-06-01

    Full Text Available This paper primarily presents detailed design and implementation of a low complex magnetic levitation system which can be used in laboratory for levitation experiments. The system transfer function was derived from the coenergy and the mathematical model of the state space representation was obtained. The mathematical model showed that, the system is highly non-linear and inherently unstable. Based on simulation, a low complex circuit was designed and implemented to stabilize the system, using MATLAB control tool-box. The developed controller was simple, cheap and effective, capable of controlling weights of different masses at various distances as compared to some controllers in literature.

  7. What Is a Complex Innovation System?

    Science.gov (United States)

    Katz, J. Sylvan

    2016-01-01

    Innovation systems are sometimes referred to as complex systems, something that is intuitively understood but poorly defined. A complex system dynamically evolves in non-linear ways giving it unique properties that distinguish it from other systems. In particular, a common signature of complex systems is scale-invariant emergent properties. A scale-invariant property can be identified because it is solely described by a power law function, f(x) = kxα, where the exponent, α, is a measure of scale-invariance. The focus of this paper is to describe and illustrate that innovation systems have properties of a complex adaptive system. In particular scale-invariant emergent properties indicative of their complex nature that can be quantified and used to inform public policy. The global research system is an example of an innovation system. Peer-reviewed publications containing knowledge are a characteristic output. Citations or references to these articles are an indirect measure of the impact the knowledge has on the research community. Peer-reviewed papers indexed in Scopus and in the Web of Science were used as data sources to produce measures of sizes and impact. These measures are used to illustrate how scale-invariant properties can be identified and quantified. It is demonstrated that the distribution of impact has a reasonable likelihood of being scale-invariant with scaling exponents that tended toward a value of less than 3.0 with the passage of time and decreasing group sizes. Scale-invariant correlations are shown between the evolution of impact and size with time and between field impact and sizes at points in time. The recursive or self-similar nature of scale-invariance suggests that any smaller innovation system within the global research system is likely to be complex with scale-invariant properties too. PMID:27258040

  8. Vibrations and stability of complex beam systems

    CERN Document Server

    Stojanović, Vladimir

    2015-01-01

     This book reports on solved problems concerning vibrations and stability of complex beam systems. The complexity of a system is considered from two points of view: the complexity originating from the nature of the structure, in the case of two or more elastically connected beams; and the complexity derived from the dynamic behavior of the system, in the case of a damaged single beam, resulting from the harm done to its simple structure. Furthermore, the book describes the analytical derivation of equations of two or more elastically connected beams, using four different theories (Euler, Rayleigh, Timoshenko and Reddy-Bickford). It also reports on a new, improved p-version of the finite element method for geometrically nonlinear vibrations. The new method provides more accurate approximations of solutions, while also allowing us to analyze geometrically nonlinear vibrations. The book describes the appearance of longitudinal vibrations of damaged clamped-clamped beams as a result of discontinuity (damage). It...

  9. Signs, Systems and Complexity of Transmedia Storytelling

    Directory of Open Access Journals (Sweden)

    Renira Rampazzo Gambarato

    2012-12-01

    Full Text Available This article addresses key concepts such as sign, system and complexity in order to approach transmedia storytelling and better understand its intricate nature. The theoretical framework chosen to investigate transmedia storytelling meanders is Semiotics by Charles Sanders Peirce (1839-1914 and General Systems Theory by Mario Bunge (1919-. The complexity of transmedia storytelling is not simply the one of the signs of the works included in a transmedia franchise. It also includes the complexity of the dispositions of users/consumers/players as interpreters of semiotic elements (e.g. characters, themes, environments, events and outcomes presented by transmedia products. It extends further to the complexity of social, cultural, economical and political constructs. The German transmedia narrative The Ultimate SuperHero-Blog by Stefan Gieren and Sofia’s Diary, a Portuguese multiplatform production by BeActive, are presented as examples of closed and open system transmedia storytelling respectively.

  10. Symptoms of complexity in a tourism system

    CERN Document Server

    Baggio, R

    2007-01-01

    Tourism destinations behave as dynamic evolving complex systems, encompassing numerous factors and activities which are interdependent and whose relationships might be highly nonlinear. Traditional research in this field has looked after a linear approach: variables and relationships are monitored in order to forecast future outcomes with simplified models and to derive implications for management organizations. The limitations of this approach have become apparent in many cases, and several authors claim for a new and different attitude. While complex systems ideas are amongst the most promising interdisciplinary research themes emerged in the last few decades, very little has been done so far in the field of tourism. This paper presents a brief overview of the complexity framework as a means to understand structures, characteristics, relationships and explores the implications and contributions of the complexity literature on tourism systems. The objective is to allow the reader to gain a deeper appreciatio...

  11. Advanced Fabrication Techniques for Precisely Controlled Micro and Nano Scale Environments for Complex Tissue Regeneration and Biomedical Applications

    Science.gov (United States)

    Holmes, Benjamin

    As modern medicine advances, it is still very challenging to cure joint defects due to their poor inherent regenerative capacity, complex stratified architecture, and disparate biomechanical properties. The current clinical standard for catastrophic or late stage joint degradation is a total joint implant, where the damaged joint is completely excised and replaced with a metallic or artificial joint. However, these procedures still only lasts for 10-15 years, and there are hosts of recovery complications which can occur. Thus, these studies have sought to employ advanced biomaterials and scaffold fabricated techniques to effectively regrow joint tissue, instead of merely replacing it with artificial materials. We can hypothesize here that the inclusion of biomimetic and bioactive nanomaterials with highly functional electrospun and 3D printed scaffold can improve physical characteristics (mechanical strength, surface interactions and nanotexture) enhance cellular growth and direct stem cell differentiation for bone, cartilage and vascular growth as well as cancer metastasis modeling. Nanomaterial inclusion and controlled 3D printed features effectively increased nano surface roughness, Young's Modulus and provided effective flow paths for simulated arterial blood. All of the approaches explored proved highly effective for increasing cell growth, as a result of increasing micro-complexity and nanomaterial incorporation. Additionally, chondrogenic and osteogenic differentiation, cell migration, cell to cell interaction and vascular formation were enhanced. Finally, growth-factor(gf)-loaded polymer nanospheres greatly improved vascular cell behavior, and provided a highly bioactive scaffold for mesenchymal stem cell (MSC) and human umbilical vein endothelial cell (HUVEC) co-culture and bone formation. In conclusion, electrospinning and 3D printing when combined effectively with biomimetic and bioactive nanomaterials (i.e. carbon nanomaterials, collagen, nHA, polymer

  12. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2013-01-01

    Complex system theory is rapidly developing and gaining importance, providing tools and concepts central to our modern understanding of emergent phenomena. This primer offers an introduction to this area together with detailed coverage of the mathematics involved. All calculations are presented step by step and are straightforward to follow. This new third edition comes with new material, figures and exercises. Network theory, dynamical systems and information theory, the core of modern complex system sciences, are developed in the first three chapters, covering basic concepts and phenomena like small-world networks, bifurcation theory and information entropy. Further chapters use a modular approach to address the most important concepts in complex system sciences, with the emergence and self-organization playing a central role. Prominent examples are self-organized criticality in adaptive systems, life at the edge of chaos, hypercycles and coevolutionary avalanches, synchronization phenomena, absorbing phase...

  13. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2007-01-01

    We are living in an ever more complex world, an epoch where human actions can accordingly acquire far-reaching potentialities. Complex and adaptive dynamical systems are ubiquitous in the world surrounding us and require us to adapt to new realities and the way of dealing with them. This primer has been developed with the aim of conveying a wide range of "commons-sense" knowledge in the field of quantitative complex system science at an introductory level, providing an entry point to this both fascinating and vitally important subject. The approach is modular and phenomenology driven. Examples of emerging phenomena of generic importance treated in this book are: -- The small world phenomenon in social and scale-free networks. -- Phase transitions and self-organized criticality in adaptive systems. -- Life at the edge of chaos and coevolutionary avalanches resulting from the unfolding of all living. -- The concept of living dynamical systems and emotional diffusive control within cognitive system theory. Techn...

  14. Complex and Adaptive Dynamical Systems A Primer

    CERN Document Server

    Gros, Claudius

    2011-01-01

    We are living in an ever more complex world, an epoch where human actions can accordingly acquire far-reaching potentialities. Complex and adaptive dynamical systems are ubiquitous in the world surrounding us and require us to adapt to new realities and the way of dealing with them. This primer has been developed with the aim of conveying a wide range of "commons-sense" knowledge in the field of quantitative complex system science at an introductory level, providing an entry point to this both fascinating and vitally important subject. The approach is modular and phenomenology driven. Examples of emerging phenomena of generic importance treated in this book are: -- The small world phenomenon in social and scale-free networks. -- Phase transitions and self-organized criticality in adaptive systems. -- Life at the edge of chaos and coevolutionary avalanches resulting from the unfolding of all living. -- The concept of living dynamical systems and emotional diffusive control within cognitive system theory. Techn...

  15. Collectives and the design of complex systems

    CERN Document Server

    Wolpert, David

    2004-01-01

    Increasingly powerful computers are making possible distributed systems comprised of many adaptive and self-motivated computational agents. Such systems, when distinguished by system-level performance criteria, are known as "collectives." Collectives and the Design of Complex Systems lays the foundation for a science of collectives and describes how to design them for optimal performance. An introductory survey chapter is followed by descriptions of information-processing problems that can only be solved by the joint actions of large communities of computers, each running its own complex, decentralized machine-learning algorithm. Subsequent chapters analyze the dynamics and structures of collectives, as well as address economic, model-free, and control-theory approaches to designing complex systems. The work assumes a modest understanding of basic statistics and calculus. Topics and Features: Introduces the burgeoning science of collectives and its practical applications in a single useful volume Combines ap...

  16. Discontinuity and complexity in nonlinear physical systems

    CERN Document Server

    Baleanu, Dumitru; Luo, Albert

    2014-01-01

    This unique book explores recent developments in experimental research in this broad field, organized in four distinct sections. Part I introduces the reader to the fractional dynamics and Lie group analysis for nonlinear partial differential equations. Part II covers chaos and complexity in nonlinear Hamiltonian systems, important to understand the resonance interactions in nonlinear dynamical systems, such as Tsunami waves and wildfire propagations; as well as Lev flights in chaotic trajectories, dynamical system synchronization and DNA information complexity analysis. Part III examines chaos and periodic motions in discontinuous dynamical systems, extensively present in a range of systems, including piecewise linear systems, vibro-impact systems and drilling systems in engineering. And in Part IV, engineering and financial nonlinearity are discussed. The mechanism of shock wave with saddle-node bifurcation and rotating disk stability will be presented, and the financial nonlinear models will be discussed....

  17. Biomedically relevant chemical and physical properties of coal combustion products.

    OpenAIRE

    Fisher, G L

    1983-01-01

    The evaluation of the potential public and occupational health hazards of developing and existing combustion processes requires a detailed understanding of the physical and chemical properties of effluents available for human and environmental exposures. These processes produce complex mixtures of gases and aerosols which may interact synergistically or antagonistically with biological systems. Because of the physicochemical complexity of the effluents, the biomedically relevant properties of...

  18. Enabling Large-Scale Biomedical Analysis in the Cloud

    Directory of Open Access Journals (Sweden)

    Ying-Chih Lin

    2013-01-01

    Full Text Available Recent progress in high-throughput instrumentations has led to an astonishing growth in both volume and complexity of biomedical data collected from various sources. The planet-size data brings serious challenges to the storage and computing technologies. Cloud computing is an alternative to crack the nut because it gives concurrent consideration to enable storage and high-performance computing on large-scale data. This work briefly introduces the data intensive computing system and summarizes existing cloud-based resources in bioinformatics. These developments and applications would facilitate biomedical research to make the vast amount of diversification data meaningful and usable.

  19. Europium enabled luminescent nanoparticles for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Syamchand, S.S., E-mail: syamchand.ss@gmail.com; Sony, G., E-mail: emailtosony@gmail.com

    2015-09-15

    Lanthanide based nanoparticles are receiving great attention ought to their excellent luminescent and magnetic properties and find challenging biomedical applications. Among the luminescent lanthanide NPs, europium based NPs (Eu-NPs) are better candidates for immunoassay and imaging applications. The Eu-NPs have an edge over quantum dots (QDs) by means of their stable luminescence, long fluorescence lifetime, sharp emission peaks with narrow band width, lack of blinking and biocompatibility. This review surveys the synthesis and properties of a variety of Eu-NPs consolidated from different research articles, for their applications in medicine and biology. The exquisite luminescent properties of Eu-NPs are explored for developing biomedical applications such as immunoassay and bioimaging including multimodal imaging. The biomedical applications of Eu-NPs are mostly diagnostic in nature and mainly focus on various key analytes present in biological systems. The luminescent properties of europium enabled NPs are influenced by a number of factors such as the site symmetry, the metal nanoparticles, metal ions, quantum dots, surfactants, morphology of Eu-NPs, crystal defect, phenomena like antenna effect and physical parameters like temperature. Through this review we explore and assimilate all the factors which affect the luminescence in Eu-NPs and coil a new thread of parameters that control the luminescence in Eu-NPs, which would provide further insight in developing Eu-based nanoprobes for future biomedical prospects. - Highlights: • The review describes 14 major factors that influence the luminescence properties of europium enabled luminescent nanoparticles (Eu-NPs). • Surveys different types of europium containing nanoparticles that have been reported for their biomedical applications. • Eu-NPs are conveniently divided into four different categories, based on the type of the substrates involved. The four categories are (1) virgin Eu-substrate based NPs; (2

  20. Europium enabled luminescent nanoparticles for biomedical applications

    International Nuclear Information System (INIS)

    Lanthanide based nanoparticles are receiving great attention ought to their excellent luminescent and magnetic properties and find challenging biomedical applications. Among the luminescent lanthanide NPs, europium based NPs (Eu-NPs) are better candidates for immunoassay and imaging applications. The Eu-NPs have an edge over quantum dots (QDs) by means of their stable luminescence, long fluorescence lifetime, sharp emission peaks with narrow band width, lack of blinking and biocompatibility. This review surveys the synthesis and properties of a variety of Eu-NPs consolidated from different research articles, for their applications in medicine and biology. The exquisite luminescent properties of Eu-NPs are explored for developing biomedical applications such as immunoassay and bioimaging including multimodal imaging. The biomedical applications of Eu-NPs are mostly diagnostic in nature and mainly focus on various key analytes present in biological systems. The luminescent properties of europium enabled NPs are influenced by a number of factors such as the site symmetry, the metal nanoparticles, metal ions, quantum dots, surfactants, morphology of Eu-NPs, crystal defect, phenomena like antenna effect and physical parameters like temperature. Through this review we explore and assimilate all the factors which affect the luminescence in Eu-NPs and coil a new thread of parameters that control the luminescence in Eu-NPs, which would provide further insight in developing Eu-based nanoprobes for future biomedical prospects. - Highlights: • The review describes 14 major factors that influence the luminescence properties of europium enabled luminescent nanoparticles (Eu-NPs). • Surveys different types of europium containing nanoparticles that have been reported for their biomedical applications. • Eu-NPs are conveniently divided into four different categories, based on the type of the substrates involved. The four categories are (1) virgin Eu-substrate based NPs; (2

  1. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1973-01-01

    Advances in Biomedical Engineering, Volume 3, is a collection of papers that discusses circulatory system models, linguistics in computer usage, and clinical applications on patient monitoring. One paper describes the use of comparative models of overall circulatory mechanics that include models of the cardiac pump, of the vascular systems, and of the overall systems behavior. Another paper describes a model in processing medical language data that employs an explicit semantic structure, becoming the basis for the computer-based, artificial intelligence of the system. One paper cites studies b

  2. Aerostat radio-electronic systems and complexes

    OpenAIRE

    V. A. Bychkovsky; Yu. Yu. Reutskaya

    2010-01-01

    The balloon systems and complexes possibilities intended for reception of the information on extended and local anomalies of a natural and technogenic origin in territories of limited access and supervision over surface territory are considered. Methods of construction of communication channels of ballon systems with high speed of the information transfer, based on technologies 3G and 4G are analysed.

  3. Aerostat radio-electronic systems and complexes

    Directory of Open Access Journals (Sweden)

    V. A. Bychkovsky

    2010-10-01

    Full Text Available The balloon systems and complexes possibilities intended for reception of the information on extended and local anomalies of a natural and technogenic origin in territories of limited access and supervision over surface territory are considered. Methods of construction of communication channels of ballon systems with high speed of the information transfer, based on technologies 3G and 4G are analysed.

  4. (R)evolution of complex regulatory systems

    DEFF Research Database (Denmark)

    Linding, Rune

    2010-01-01

    Signaling systems are exciting to study precisely because they are some of the most complex and dynamical systems that we know. The cell needs operational freedom and, thus, many motif-domain interactions might not be "hard-wired" through evolution, but instead may be like the Linux operating...

  5. A System for Complex Robotic Welding

    DEFF Research Database (Denmark)

    Madsen, Ole; Sørensen, Carsten Bro; Olsen, Birger;

    2002-01-01

    This paper presents the architecture of a system for robotic welding of complex tasks. The system integrates off-line programming, control of redundant robots, collision-free motion planning and sensor-based control. An implementation for pipe structure welding made at Odense Steel Shipyard Ltd...

  6. Design tools for complex dynamic security systems.

    Energy Technology Data Exchange (ETDEWEB)

    Byrne, Raymond Harry; Rigdon, James Brian; Rohrer, Brandon Robinson; Laguna, Glenn A.; Robinett, Rush D. III (.; ); Groom, Kenneth Neal; Wilson, David Gerald; Bickerstaff, Robert J.; Harrington, John J.

    2007-01-01

    The development of tools for complex dynamic security systems is not a straight forward engineering task but, rather, a scientific task where discovery of new scientific principles and math is necessary. For years, scientists have observed complex behavior but have had difficulty understanding it. Prominent examples include: insect colony organization, the stock market, molecular interactions, fractals, and emergent behavior. Engineering such systems will be an even greater challenge. This report explores four tools for engineered complex dynamic security systems: Partially Observable Markov Decision Process, Percolation Theory, Graph Theory, and Exergy/Entropy Theory. Additionally, enabling hardware technology for next generation security systems are described: a 100 node wireless sensor network, unmanned ground vehicle and unmanned aerial vehicle.

  7. Are large complex economic systems unstable ?

    CERN Document Server

    Sinha, Sitabhra

    2010-01-01

    Although classical economic theory is based on the concept of stable equilibrium, real economic systems appear to be always out of equilibrium. Indeed, they share many of the dynamical features of other complex systems, e.g., ecological food-webs. We focus on the relation between increasing complexity of the economic network and its stability with respect to small perturbations in the dynamical variables associated with the constituent nodes. Inherent delays and multiple time-scales suggest that economic systems will be more likely to exhibit instabilities as their complexity is increased even though the speed at which transactions are conducted has increased many-fold through technological developments. Analogous to the birth of nonlinear dynamics from Poincare's work on the question of whether the solar system is stable, we suggest that similar theoretical developments may arise from efforts by econophysicists to understand the mechanisms by which instabilities arise in the economy.

  8. SORTA: a system for ontology-based re-coding and technical annotation of biomedical phenotype data.

    Science.gov (United States)

    Pang, Chao; Sollie, Annet; Sijtsma, Anna; Hendriksen, Dennis; Charbon, Bart; de Haan, Mark; de Boer, Tommy; Kelpin, Fleur; Jetten, Jonathan; van der Velde, Joeri K; Smidt, Nynke; Sijmons, Rolf; Hillege, Hans; Swertz, Morris A

    2015-01-01

    There is an urgent need to standardize the semantics of biomedical data values, such as phenotypes, to enable comparative and integrative analyses. However, it is unlikely that all studies will use the same data collection protocols. As a result, retrospective standardization is often required, which involves matching of original (unstructured or locally coded) data to widely used coding or ontology systems such as SNOMED CT (clinical terms), ICD-10 (International Classification of Disease) and HPO (Human Phenotype Ontology). This data curation process is usually a time-consuming process performed by a human expert. To help mechanize this process, we have developed SORTA, a computer-aided system for rapidly encoding free text or locally coded values to a formal coding system or ontology. SORTA matches original data values (uploaded in semicolon delimited format) to a target coding system (uploaded in Excel spreadsheet, OWL ontology web language or OBO open biomedical ontologies format). It then semi- automatically shortlists candidate codes for each data value using Lucene and n-gram based matching algorithms, and can also learn from matches chosen by human experts. We evaluated SORTA's applicability in two use cases. For the LifeLines biobank, we used SORTA to recode 90 000 free text values (including 5211 unique values) about physical exercise to MET (Metabolic Equivalent of Task) codes. For the CINEAS clinical symptom coding system, we used SORTA to map to HPO, enriching HPO when necessary (315 terms matched so far). Out of the shortlists at rank 1, we found a precision/recall of 0.97/0.98 in LifeLines and of 0.58/0.45 in CINEAS. More importantly, users found the tool both a major time saver and a quality improvement because SORTA reduced the chances of human mistakes. Thus, SORTA can dramatically ease data (re)coding tasks and we believe it will prove useful for many more projects. Database URL: http://molgenis.org/sorta or as an open source download from

  9. Particlelike wave packets in complex scattering systems

    Science.gov (United States)

    Gérardin, Benoît; Laurent, Jérôme; Ambichl, Philipp; Prada, Claire; Rotter, Stefan; Aubry, Alexandre

    2016-07-01

    A wave packet undergoes a strong spatial and temporal dispersion while propagating through a complex medium. This wave scattering is often seen as a nightmare in wave physics whether it be for focusing, imaging, or communication purposes. Controlling wave propagation through complex systems is thus of fundamental interest in many areas, ranging from optics or acoustics to medical imaging or telecommunications. Here, we study the propagation of elastic waves in a cavity and a disordered waveguide by means of laser interferometry. From the direct experimental access to the time-delay matrix of these systems, we demonstrate the existence of particlelike wave packets that remain focused in time and space throughout their complex trajectory. Due to their limited dispersion, their selective excitation will be crucially relevant for all applications involving selective wave focusing and efficient information transfer through complex media.

  10. Ecological Systems as Complex Systems: Challenges for an Emerging Science

    Directory of Open Access Journals (Sweden)

    Lael Parrott

    2010-03-01

    Full Text Available Complex systems science has contributed to our understanding of ecology in important areas such as food webs, patch dynamics and population fluctuations. This has been achieved through the use of simple measures that can capture the difference between order and disorder and simple models with local interactions that can generate surprising behaviour at larger scales. However, close examination reveals that commonly applied definitions of complexity fail to accommodate some key features of ecological systems, a fact that will limit the contribution of complex systems science to ecology. We highlight these features of ecological complexity—such as diversity, cross-scale interactions, memory and environmental variability—that continue to challenge classical complex systems science. Further advances in these areas will be necessary before complex systems science can be widely applied to understand the dynamics of ecological systems.

  11. On Phenomenology of Complex Scientific Systems

    CERN Document Server

    Shiltsev, Vladimir

    2011-01-01

    Performance evolution of a number of complex scientific and technical systems demonstrate exponential progress with time exp(+t/C) . The speed of progress C - a measure of difficulty and complexity - is analyzed for high energy elementary particle colliders, astrophysical searches for galaxies and exoplanets, protein structure determination and compared with computers and thermonuclear fusion reactors. An explanation of the characteristic exponential progress is offered.

  12. Toxicology of Biomedical Polymers

    Directory of Open Access Journals (Sweden)

    P. V. Vedanarayanan

    1987-04-01

    Full Text Available This paper deals with the various types of polymers, used in the fabrication of medical devices, their diversity of applications and toxic hazards which may arise out of their application. The potential toxicity of monomers and the various additives used in the manufacture of biomedical polymers have been discussed along with hazards which may arise out of processing of devices such as sterilization. The importance of quality control and stringent toxicity evaluation methods have been emphasised since in our country, at present, there are no regulations covering the manufacturing and marketing of medical devices. Finally the question of the general and subtle long term systemic toxicity of biomedical polymers have been brought to attention with the suggestion that this question needs to be resolved permanently by appropriate studies.

  13. Science gateways for biomedical big data analysis

    OpenAIRE

    Kampen, van, PJW; Olabarriaga, S.D.; Shahand, S.

    2015-01-01

    Biomedical researchers are facing data deluge challenges such as dealing with large volume of complex heterogeneous data and complex and computationally demanding data processing methods. Such scale and complexity of biomedical research requires multi-disciplinary collaboration between scientists from different organizations. Data-driven or e-Science methods are defined as a combination of Information Technology (IT) and science that enables scientists to tackle the data deluge challenges. Th...

  14. Distributed redundancy and robustness in complex systems

    KAUST Repository

    Randles, Martin

    2011-03-01

    The uptake and increasing prevalence of Web 2.0 applications, promoting new large-scale and complex systems such as Cloud computing and the emerging Internet of Services/Things, requires tools and techniques to analyse and model methods to ensure the robustness of these new systems. This paper reports on assessing and improving complex system resilience using distributed redundancy, termed degeneracy in biological systems, to endow large-scale complicated computer systems with the same robustness that emerges in complex biological and natural systems. However, in order to promote an evolutionary approach, through emergent self-organisation, it is necessary to specify the systems in an \\'open-ended\\' manner where not all states of the system are prescribed at design-time. In particular an observer system is used to select robust topologies, within system components, based on a measurement of the first non-zero Eigen value in the Laplacian spectrum of the components\\' network graphs; also known as the algebraic connectivity. It is shown, through experimentation on a simulation, that increasing the average algebraic connectivity across the components, in a network, leads to an increase in the variety of individual components termed distributed redundancy; the capacity for structurally distinct components to perform an identical function in a particular context. The results are applied to a specific application where active clustering of like services is used to aid load balancing in a highly distributed network. Using the described procedure is shown to improve performance and distribute redundancy. © 2010 Elsevier Inc.

  15. Stochastic Physics, Complex Systems and Biology

    CERN Document Server

    Qian, Hong

    2012-01-01

    In complex systems, the interplay between nonlinear and stochastic dynamics gives rise to an evolution process in Darwinian sense with punctuated equilibrium, random "mutations" and "adaptations". The emergent discrete states in such a system, i.e., attractors, have natural robustness against both internal and external perturbations. Epigenetic states of a biological cell, a mesoscopic nonlinear stochastic open biochemical system, could be understood through such a framework.

  16. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains selected transcripts from presentations given at the conference. Speakers include: Chris Adami, Kenneth Arrow, Michel Baranger, Dan Braha, Timothy Buchman, Michael Caramanis, Kathleen Carley, Greg Chaitin, David Clark, Jack Cohen, Jim Collins, George Cowan, Clay Easterly, Steven Eppinger, Irving Epstein, Dan Frey, Ary Goldberger, Helen Harte, Leroy Hood, Don Ingber, Atlee Jackson,...

  17. Conceptual Modelling of Complex Production Systems

    Directory of Open Access Journals (Sweden)

    Nenad Perši

    2008-12-01

    Full Text Available Complex system dynamics, structure and behaviour performances call for a wide range of methods, algorithms and tools to reach a model capable of finding optimal performing parameters. In the modelling process, it is up to the analyst to select the appropriate combination of methods, algorithms and tools to express significant system performances. Such a methodology for designing complex systems should be based upon conceptual modelling to perform a sensitive analysis of different system levels and views, allowing system representations for developing computer models.Complex systems, such as business systems with a continuous-discrete production process, require a well organised supply chain highly reactive to production assortment changes. Aligning two different production components distinctive in their behaviour is especially delicate at the production parameters transition point. Such system performances require distinctive designing methods that can follow the double nature of the production process behaviour in accordance with their entities dynamics caused by assortment changes. Consequently, such systems need different conceptual presentations for their purpose to be realized from different views and aspects.

  18. Complex Adaptive Systems of Systems (CASOS) engineering environment.

    Energy Technology Data Exchange (ETDEWEB)

    Detry, Richard Joseph; Linebarger, John Michael; Finley, Patrick D.; Maffitt, S. Louise; Glass, Robert John, Jr.; Beyeler, Walter Eugene; Ames, Arlo Leroy

    2012-02-01

    Complex Adaptive Systems of Systems, or CASoS, are vastly complex physical-socio-technical systems which we must understand to design a secure future for the nation. The Phoenix initiative implements CASoS Engineering principles combining the bottom up Complex Systems and Complex Adaptive Systems view with the top down Systems Engineering and System-of-Systems view. CASoS Engineering theory and practice must be conducted together to develop a discipline that is grounded in reality, extends our understanding of how CASoS behave and allows us to better control the outcomes. The pull of applications (real world problems) is critical to this effort, as is the articulation of a CASoS Engineering Framework that grounds an engineering approach in the theory of complex adaptive systems of systems. Successful application of the CASoS Engineering Framework requires modeling, simulation and analysis (MS and A) capabilities and the cultivation of a CASoS Engineering Community of Practice through knowledge sharing and facilitation. The CASoS Engineering Environment, itself a complex adaptive system of systems, constitutes the two platforms that provide these capabilities.

  19. Bio-Swarm-Pipeline: a light-weight, extensible batch processing system for efficient biomedical data processing

    Directory of Open Access Journals (Sweden)

    Xi Cheng

    2009-10-01

    Full Text Available A streamlined scientific workflow system that can track the details of the data processing history is critical for the efficient handling of fundamental routines used in scientific research. In the scientific workflow research community, the information that describes the details of data processing history is referred to as provenance which plays an important role in most of the existing workflow management systems. Despite its importance, however, provenance modeling and management is still a relatively new area in the scientific workflow research community. The proper scope, representation, granularity and implementation of a provenance model can vary from domain to domain and pose a number of challenges for an efficient pipeline design. This paper provides a case study on structured provenance modeling and management problems in the neuroimaging domain by introducing the Bio-Swarm-Pipeline (BSP. This new model, which is evaluated in the paper through real world scenarios, systematically addresses the provenance scope, representation, granularity, and implementation issues related to the neuroimaging domain. Although this model stems from applications in neuroimaging, the system can potentially be adapted to a wide range of bio-medical application scenarios.

  20. Toolsets Maintain Health of Complex Systems

    Science.gov (United States)

    2010-01-01

    First featured in Spinoff 2001, Qualtech Systems Inc. (QSI), of Wethersfield, Connecticut, adapted its Testability, Engineering, and Maintenance System (TEAMS) toolset under Small Business Innovation Research (SBIR) contracts from Ames Research Center to strengthen NASA's systems health management approach for its large, complex, and interconnected systems. Today, six NASA field centers utilize the TEAMS toolset, including TEAMS-Designer, TEAMS-RT, TEAMATE, and TEAMS-RDS. TEAMS is also being used on industrial systems that generate power, carry data, refine chemicals, perform medical functions, and produce semiconductor wafers. QSI finds TEAMS can lower costs by decreasing problems requiring service by 30 to 50 percent.

  1. Environmental/Biomedical Terminology Index

    Energy Technology Data Exchange (ETDEWEB)

    Huffstetler, J.K.; Dailey, N.S.; Rickert, L.W.; Chilton, B.D.

    1976-12-01

    The Information Center Complex (ICC), a centrally administered group of information centers, provides information support to environmental and biomedical research groups and others within and outside Oak Ridge National Laboratory. In-house data base building and development of specialized document collections are important elements of the ongoing activities of these centers. ICC groups must be concerned with language which will adequately classify and insure retrievability of document records. Language control problems are compounded when the complexity of modern scientific problem solving demands an interdisciplinary approach. Although there are several word lists, indexes, and thesauri specific to various scientific disciplines usually grouped as Environmental Sciences, no single generally recognized authority can be used as a guide to the terminology of all environmental science. If biomedical terminology for the description of research on environmental effects is also needed, the problem becomes even more complex. The building of a word list which can be used as a general guide to the environmental/biomedical sciences has been a continuing activity of the Information Center Complex. This activity resulted in the publication of the Environmental Biomedical Terminology Index (EBTI).

  2. Environmental/Biomedical Terminology Index

    International Nuclear Information System (INIS)

    The Information Center Complex (ICC), a centrally administered group of information centers, provides information support to environmental and biomedical research groups and others within and outside Oak Ridge National Laboratory. In-house data base building and development of specialized document collections are important elements of the ongoing activities of these centers. ICC groups must be concerned with language which will adequately classify and insure retrievability of document records. Language control problems are compounded when the complexity of modern scientific problem solving demands an interdisciplinary approach. Although there are several word lists, indexes, and thesauri specific to various scientific disciplines usually grouped as Environmental Sciences, no single generally recognized authority can be used as a guide to the terminology of all environmental science. If biomedical terminology for the description of research on environmental effects is also needed, the problem becomes even more complex. The building of a word list which can be used as a general guide to the environmental/biomedical sciences has been a continuing activity of the Information Center Complex. This activity resulted in the publication of the Environmental Biomedical Terminology Index

  3. Mapping complex traits as a dynamic system

    Science.gov (United States)

    Sun, Lidan; Wu, Rongling

    2015-06-01

    Despite increasing emphasis on the genetic study of quantitative traits, we are still far from being able to chart a clear picture of their genetic architecture, given an inherent complexity involved in trait formation. A competing theory for studying such complex traits has emerged by viewing their phenotypic formation as a "system" in which a high-dimensional group of interconnected components act and interact across different levels of biological organization from molecules through cells to whole organisms. This system is initiated by a machinery of DNA sequences that regulate a cascade of biochemical pathways to synthesize endophenotypes and further assemble these endophenotypes toward the end-point phenotype in virtue of various developmental changes. This review focuses on a conceptual framework for genetic mapping of complex traits by which to delineate the underlying components, interactions and mechanisms that govern the system according to biological principles and understand how these components function synergistically under the control of quantitative trait loci (QTLs) to comprise a unified whole. This framework is built by a system of differential equations that quantifies how alterations of different components lead to the global change of trait development and function, and provides a quantitative and testable platform for assessing the multiscale interplay between QTLs and development. The method will enable geneticists to shed light on the genetic complexity of any biological system and predict, alter or engineer its physiological and pathological states.

  4. Multiphase reliability analysis of complex systems

    Science.gov (United States)

    Azam, Mohammad S.; Tu, Fang; Pattipati, Krishna R.

    2003-08-01

    Modern industrial systems assume different configurations to accomplish multiple objectives during different phases of operation, and the component parameters may also vary from one phase to the next. Consequently, reliability evaluation of complex multi-phased systems is a vital and challenging issue. Maximization of mission reliability of a multi-phase system via optimal asset selection is another key demand; incorporation of optimization issues adds to the complexities of reliability evaluation processes. Introduction of components having self-diagnostics and self-recovery capabilities, along with increased complexity and phase-dependent configuration variations in network architectures, requires new approaches for reliability evaluation. This paper considers the problem of evaluating the reliability of a complex multi-phased system with self-recovery/fault-protection options. The reliability analysis is based on a colored digraph (i.e., multi-functional) model that subsumes fault trees and digraphs as special cases. These models enable system designers to decide on system architecture modifications and to determine the optimum levels of redundancy. A sum of disjoint products (SDP) approach is employed to compute system reliability. We also formulated the problem of optimal asset selection in a multi-phase system as one of maximizing the probability of mission success under random load profiles on components. Different methods (e.g., ordinal optimization, robust design, and nonparametric statistical testing) are explored to solve the problem. The resulting analytical expressions and the software tool are demonstrated on a generic programmable software-controlled switchgear, a data bus controller system and a multi-phase mission involving helicopters.

  5. Complex Protection System of Metadata-based Distributed Information Systems

    OpenAIRE

    Kourilov, Denis; Lyadova, Lyudmila

    2008-01-01

    A description of architecture and approaches to the implementation of a protection system of metadatabased adaptable information systems is suggested. Various protection means are examined. The system described is a multilevel complex based on a multiagent system combining IDS functional abilities with structure and logics protection means.

  6. Extraction of quantifiable information from complex systems

    CERN Document Server

    Dahmen, Wolfgang; Griebel, Michael; Hackbusch, Wolfgang; Ritter, Klaus; Schneider, Reinhold; Schwab, Christoph; Yserentant, Harry

    2014-01-01

    In April 2007, the  Deutsche Forschungsgemeinschaft (DFG) approved the  Priority Program 1324 “Mathematical Methods for Extracting Quantifiable Information from Complex Systems.” This volume presents a comprehensive overview of the most important results obtained over the course of the program.   Mathematical models of complex systems provide the foundation for further technological developments in science, engineering and computational finance.  Motivated by the trend toward steadily increasing computer power, ever more realistic models have been developed in recent years. These models have also become increasingly complex, and their numerical treatment poses serious challenges.   Recent developments in mathematics suggest that, in the long run, much more powerful numerical solution strategies could be derived if the interconnections between the different fields of research were systematically exploited at a conceptual level. Accordingly, a deeper understanding of the mathematical foundations as w...

  7. Constructing minimal models for complex system dynamics

    Science.gov (United States)

    Barzel, Baruch; Liu, Yang-Yu; Barabási, Albert-László

    2015-05-01

    One of the strengths of statistical physics is the ability to reduce macroscopic observations into microscopic models, offering a mechanistic description of a system's dynamics. This paradigm, rooted in Boltzmann's gas theory, has found applications from magnetic phenomena to subcellular processes and epidemic spreading. Yet, each of these advances were the result of decades of meticulous model building and validation, which are impossible to replicate in most complex biological, social or technological systems that lack accurate microscopic models. Here we develop a method to infer the microscopic dynamics of a complex system from observations of its response to external perturbations, allowing us to construct the most general class of nonlinear pairwise dynamics that are guaranteed to recover the observed behaviour. The result, which we test against both numerical and empirical data, is an effective dynamic model that can predict the system's behaviour and provide crucial insights into its inner workings.

  8. Managing interoperability and complexity in health systems.

    Science.gov (United States)

    Bouamrane, M-M; Tao, C; Sarkar, I N

    2015-01-01

    In recent years, we have witnessed substantial progress in the use of clinical informatics systems to support clinicians during episodes of care, manage specialised domain knowledge, perform complex clinical data analysis and improve the management of health organisations' resources. However, the vision of fully integrated health information eco-systems, which provide relevant information and useful knowledge at the point-of-care, remains elusive. This journal Focus Theme reviews some of the enduring challenges of interoperability and complexity in clinical informatics systems. Furthermore, a range of approaches are proposed in order to address, harness and resolve some of the many remaining issues towards a greater integration of health information systems and extraction of useful or new knowledge from heterogeneous electronic data repositories. PMID:25579862

  9. Energy Consumption Monitoring System for Large Complexes

    Science.gov (United States)

    Jorge, André; Guerreiro, João; Pereira, Pedro; Martins, João; Gomes, Luís

    This paper describes the development of an open source system for monitoring and data acquisition of several energy analyzers. The developed system is based on a computer with Internet/Intranet connection by means of RS485 using Modbus RTU as communication protocol. The monitoring/metering system was developed for large building complexes and was validated in the Faculdade de Ciências e Tecnologia University campus. The system considers two distinct applications. The first one allows the user to verify, in real time, the energy consumption of any department in the complex, produce load diagrams, tables and print, email or save all available data. The second application keeps records of active/reactive energy consumption in order to verify the existence of some anomalous situation, and also monthly charge energy consumption to each corresponding department.

  10. Resource Letter CS-1: Complex Systems

    Science.gov (United States)

    Newman, M. E. J.

    2011-08-01

    A complex system is a system composed of many interacting parts, often called agents, which displays collective behavior that does not follow trivially from the behaviors of the individual parts. Examples include condensed-matter systems, ecosystems, stock markets and economies, biological evolution, and indeed the whole of human society. Substantial progress has been made in the quantitative understanding of complex systems, particularly since the 1980s, using a combination of basic theory, much of it derived from physics, and computer simulation. The subject is a broad one, drawing on techniques and ideas from a wide range of areas. Here, I give a selection of introductory resources, ranging from classic papers to recent books and reviews.

  11. Morphogenetic Engineering Toward Programmable Complex Systems

    CERN Document Server

    Sayama, Hiroki; Michel, Olivier

    2012-01-01

    Generally, spontaneous pattern formation phenomena are random and repetitive, whereas elaborate devices are the deterministic product of human design. Yet, biological organisms and collective insect constructions are exceptional examples of complex systems that are both self-organized and architectural.   This book is the first initiative of its kind toward establishing a new field of research, Morphogenetic Engineering, to explore the modeling and implementation of “self-architecturing” systems. Particular emphasis is placed on the programmability and computational abilities of self-organization, properties that are often underappreciated in complex systems science—while, conversely, the benefits of self-organization are often underappreciated in engineering methodologies.   Altogether, the aim of this work is to provide a framework for and examples of a larger class of “self-architecturing” systems, while addressing fundamental questions such as   > How do biological organisms carry out morphog...

  12. Complex and adaptive dynamical systems a primer

    CERN Document Server

    Gros, Claudius

    2015-01-01

    This primer offers readers an introduction to the central concepts that form our modern understanding of complex and emergent behavior, together with detailed coverage of accompanying mathematical methods. All calculations are presented step by step and are easy to follow. This new fourth edition has been fully reorganized and includes new chapters, figures and exercises. The core aspects of modern complex system sciences are presented in the first chapters, covering network theory, dynamical systems, bifurcation and catastrophe theory, chaos and adaptive processes, together with the principle of self-organization in reaction-diffusion systems and social animals. Modern information theoretical principles are treated in further chapters, together with the concept of self-organized criticality, gene regulation networks, hypercycles and coevolutionary avalanches, synchronization phenomena, absorbing phase transitions and the cognitive system approach to the brain. Technical course prerequisites are the standard ...

  13. An Inductive Link-Based Wireless Power Transfer System for Biomedical Applications

    OpenAIRE

    Adeeb, M. A.; A. B. Islam; Haider, M. R.; F. S. Tulip; M. N. Ericson; Islam, S. K.

    2012-01-01

    A wireless power transfer system using an inductive link has been demonstrated for implantable sensor applications. The system is composed of two primary blocks: an inductive power transfer unit and a backward data communication unit. The inductive link performs two functions: coupling the required power from a wireless power supply system enabling battery-less, long-term implant operation and providing a backward data transmission path. The backward data communication unit transmits the data...

  14. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  15. Optimal sensor configuration for complex systems

    DEFF Research Database (Denmark)

    Sadegh, Payman; Spall, J. C.

    1998-01-01

    The paper considers the problem of sensor configuration for complex systems with the aim of maximizing the useful information about certain quantities of interest. Our approach involves: 1) definition of an appropriate optimality criterion or performance measure; and 2) description of an efficient...

  16. Ensemble annealing of complex physical systems

    OpenAIRE

    Habeck, Michael

    2015-01-01

    Algorithms for simulating complex physical systems or solving difficult optimization problems often resort to an annealing process. Rather than simulating the system at the temperature of interest, an annealing algorithm starts at a temperature that is high enough to ensure ergodicity and gradually decreases it until the destination temperature is reached. This idea is used in popular algorithms such as parallel tempering and simulated annealing. A general problem with annealing methods is th...

  17. Exergy Analysis of Complex Ship Energy Systems

    OpenAIRE

    Pierre Marty; Jean-François Hétet; David Chalet; Philippe Corrignan

    2016-01-01

    With multiple primary and secondary energy converters (diesel engines, steam turbines, waste heat recovery (WHR) and oil-fired boilers, etc.) and extensive energy networks (steam, cooling water, exhaust gases, etc.), ships may be considered as complex energy systems. Understanding and optimizing such systems requires advanced holistic energy modeling. This modeling can be done in two ways: The simpler approach focuses on energy flows, and has already been tested, approved and presented; a new...

  18. Student Response (Clicker) Systems: Preferences of Biomedical Physiology Students in Asian Classes

    Science.gov (United States)

    Hwang, Isabel; Wong, Kevin; Lam, Shun Leung; Lam, Paul

    2015-01-01

    Student response systems (commonly called "clickers") are valuable tools for engaging students in classroom interactions. In this study, we investigated the use of two types of response systems (a traditional clicker and a mobile device) by students in human physiology courses. Our results showed high student satisfaction with the use of…

  19. The Clinical Practice Library of Medicine (CPLM): An on-line biomedical computer library. System documentation

    Science.gov (United States)

    Grams, R. R.

    1982-01-01

    A system designed to access a large range of available medical textbook information in an online interactive fashion is described. A high level query type database manager, INQUIRE, is used. Operating instructions, system flow diagrams, database descriptions, text generation, and error messages are discussed. User information is provided.

  20. Existence of travelling wave solutions for a Fisher-Kolmogorov system with biomedical applications

    Science.gov (United States)

    Belmonte-Beitia, Juan

    2016-07-01

    We consider a Fisher-Kolmogorov system with applications in oncology Pérez-García et al. (2015). Of interest is the question of the existence of travelling front solutions of the system. When the speed of the travelling wave is sufficiently large, existence of such fronts is shown using singular geometric perturbation theory.

  1. Dependency visualization for complex system understanding

    Energy Technology Data Exchange (ETDEWEB)

    Smart, J.A.C.

    1994-09-01

    With the volume of software in production use dramatically increasing, the importance of software maintenance has become strikingly apparent. Techniques now sought and developed for reverse engineering and design extraction and recovery. At present, numerous commercial products and research tools exist which are capable of visualizing a variety of programming languages and software constructs. The list of new tools and services continues to grow rapidly. Although the scope of the existing commercial and academic product set is quite broad, these tools still share a common underlying problem. The ability of each tool to visually organize object representations is increasingly impaired as the number of components and component dependencies within systems increases. Regardless of how objects are defined, complex ``spaghetti`` networks result in nearly all large system cases. While this problem is immediately apparent in modem systems analysis involving large software implementations, it is not new. As will be discussed in Chapter 2, related problems involving the theory of graphs were identified long ago. This important theoretical foundation provides a useful vehicle for representing and analyzing complex system structures. While the utility of directed graph based concepts in software tool design has been demonstrated in literature, these tools still lack the capabilities necessary for large system comprehension. This foundation must therefore be expanded with new orgnizational and visualization constructs necessary to meet this challenge. This dissertation addresses this need by constructing a conceptual model and a set of methods for interactively exploring, organizing, and understanding the structure of complex software systems.

  2. Biomedical semantics in the Semantic Web.

    Science.gov (United States)

    Splendiani, Andrea; Burger, Albert; Paschke, Adrian; Romano, Paolo; Marshall, M Scott

    2011-01-01

    The Semantic Web offers an ideal platform for representing and linking biomedical information, which is a prerequisite for the development and application of analytical tools to address problems in data-intensive areas such as systems biology and translational medicine. As for any new paradigm, the adoption of the Semantic Web offers opportunities and poses questions and challenges to the life sciences scientific community: which technologies in the Semantic Web stack will be more beneficial for the life sciences? Is biomedical information too complex to benefit from simple interlinked representations? What are the implications of adopting a new paradigm for knowledge representation? What are the incentives for the adoption of the Semantic Web, and who are the facilitators? Is there going to be a Semantic Web revolution in the life sciences?We report here a few reflections on these questions, following discussions at the SWAT4LS (Semantic Web Applications and Tools for Life Sciences) workshop series, of which this Journal of Biomedical Semantics special issue presents selected papers from the 2009 edition, held in Amsterdam on November 20th. PMID:21388570

  3. Classification of time series patterns from complex dynamic systems

    Energy Technology Data Exchange (ETDEWEB)

    Schryver, J.C.; Rao, N.

    1998-07-01

    An increasing availability of high-performance computing and data storage media at decreasing cost is making possible the proliferation of large-scale numerical databases and data warehouses. Numeric warehousing enterprises on the order of hundreds of gigabytes to terabytes are a reality in many fields such as finance, retail sales, process systems monitoring, biomedical monitoring, surveillance and transportation. Large-scale databases are becoming more accessible to larger user communities through the internet, web-based applications and database connectivity. Consequently, most researchers now have access to a variety of massive datasets. This trend will probably only continue to grow over the next several years. Unfortunately, the availability of integrated tools to explore, analyze and understand the data warehoused in these archives is lagging far behind the ability to gain access to the same data. In particular, locating and identifying patterns of interest in numerical time series data is an increasingly important problem for which there are few available techniques. Temporal pattern recognition poses many interesting problems in classification, segmentation, prediction, diagnosis and anomaly detection. This research focuses on the problem of classification or characterization of numerical time series data. Highway vehicles and their drivers are examples of complex dynamic systems (CDS) which are being used by transportation agencies for field testing to generate large-scale time series datasets. Tools for effective analysis of numerical time series in databases generated by highway vehicle systems are not yet available, or have not been adapted to the target problem domain. However, analysis tools from similar domains may be adapted to the problem of classification of numerical time series data.

  4. Biomedical Circuits and Systems Dedicated for Sensing and Neurostimulation: Case study on Urinary Bladder dysfunctions

    OpenAIRE

    Sawan, Mohamad; BA, Aguibou; MOUNAIM, Faycal

    2008-01-01

    This paper covers circuits and systems techniques for the construction of high reliability biosensing and neurostimulation smart medical devices. Such microsystems are dedicated for interconnections through the peripheral neural systems. Case study related to applications such as bladder control is discussed. Available electrical neurostimulation techniques for the rehabilitation of urinary bladder functions do not allow an adequate voiding due to dyssynergia between the bladder and...

  5. A Biomedical Information System for Retrieval and Manipulation of NHANES Data

    OpenAIRE

    Mukherjee, Sukrit; Martins, David; Norris, Keith C.; Jenders, Robert A

    2013-01-01

    The retrieval and manipulation of data from large public databases like the U.S. National Health and Nutrition Examination Survey (NHANES) may require sophisticated statistical software and significant expertise that may be unavailable in the university setting. In response, we have developed the Data Retrieval And Manipulation System (DReAMS), an automated information system to handle all processes of data extraction and cleaning and then joining different subsets to produce analysis-ready o...

  6. Causes of catastrophic failure in complex systems

    Science.gov (United States)

    Thomas, David A.

    2010-08-01

    Root causes of mission critical failures and major cost and schedule overruns in complex systems and programs are studied through the post-mortem analyses compiled for several examples, including the Hubble Space Telescope, the Challenger and Columbia Shuttle accidents, and the Three Mile Island nuclear power plant accident. The roles of organizational complexity, cognitive biases in decision making, the display of quantitative data, and cost and schedule pressure are all considered. Recommendations for mitigating the risk of similar failures in future programs are also provided.

  7. Unified Computational Intelligence for Complex Systems

    CERN Document Server

    Seiffertt, John

    2010-01-01

    Computational intelligence encompasses a wide variety of techniques that allow computation to learn, to adapt, and to seek. That is, they may be designed to learn information without explicit programming regarding the nature of the content to be retained, they may be imbued with the functionality to adapt to maintain their course within a complex and unpredictably changing environment, and they may help us seek out truths about our own dynamics and lives through their inclusion in complex system modeling. These capabilities place our ability to compute in a category apart from our ability to e

  8. A Multifaceted Mathematical Approach for Complex Systems

    Energy Technology Data Exchange (ETDEWEB)

    Alexander, F.; Anitescu, M.; Bell, J.; Brown, D.; Ferris, M.; Luskin, M.; Mehrotra, S.; Moser, B.; Pinar, A.; Tartakovsky, A.; Willcox, K.; Wright, S.; Zavala, V.

    2012-03-07

    Applied mathematics has an important role to play in developing the tools needed for the analysis, simulation, and optimization of complex problems. These efforts require the development of the mathematical foundations for scientific discovery, engineering design, and risk analysis based on a sound integrated approach for the understanding of complex systems. However, maximizing the impact of applied mathematics on these challenges requires a novel perspective on approaching the mathematical enterprise. Previous reports that have surveyed the DOE's research needs in applied mathematics have played a key role in defining research directions with the community. Although these reports have had significant impact, accurately assessing current research needs requires an evaluation of today's challenges against the backdrop of recent advances in applied mathematics and computing. To address these needs, the DOE Applied Mathematics Program sponsored a Workshop for Mathematics for the Analysis, Simulation and Optimization of Complex Systems on September 13-14, 2011. The workshop had approximately 50 participants from both the national labs and academia. The goal of the workshop was to identify new research areas in applied mathematics that will complement and enhance the existing DOE ASCR Applied Mathematics Program efforts that are needed to address problems associated with complex systems. This report describes recommendations from the workshop and subsequent analysis of the workshop findings by the organizing committee.

  9. Stability threshold approach for complex dynamical systems

    Science.gov (United States)

    Klinshov, Vladimir V.; Nekorkin, Vladimir I.; Kurths, Jürgen

    2016-01-01

    A new measure to characterize the stability of complex dynamical systems against large perturbations is suggested, the stability threshold (ST). It quantifies the magnitude of the weakest perturbation capable of disrupting the system and switch it to an undesired dynamical regime. In the phase space, the ST corresponds to the 'thinnest site' of the attraction basin and therefore indicates the most 'dangerous' direction of perturbations. We introduce a computational algorithm for quantification of the ST and demonstrate that the suggested approach is effective and provides important insights. The generality of the obtained results defines their vast potential for application in such fields as engineering, neuroscience, power grids, Earth science and many others where the robustness of complex systems is studied.

  10. Analysis of Complex Valve and Feed Systems

    Science.gov (United States)

    Ahuja, Vineet; Hosangadi, Ashvin; Shipman, Jeremy; Cavallo, Peter; Dash, Sanford

    2007-01-01

    A numerical framework for analysis of complex valve systems supports testing of propulsive systems by simulating key valve and control system components in the test loop. In particular, it is designed to enhance the analysis capability in terms of identifying system transients and quantifying the valve response to these transients. This system has analysis capability for simulating valve motion in complex systems operating in diverse flow regimes ranging from compressible gases to cryogenic liquids. A key feature is the hybrid, unstructured framework with sub-models for grid movement and phase change including cryogenic cavitations. The multi-element unstructured framework offers improved predictions of valve performance characteristics under steady conditions for structurally complex valves such as pressure regulator valve. Unsteady simulations of valve motion using this computational approach have been carried out for various valves in operation at Stennis Space Center such as the split-body valve and the 10-in. (approx.25.4-cm) LOX (liquid oxygen) valve and the 4-in. (approx.10 cm) Y-pattern valve (liquid nitrogen). Such simulations make use of variable grid topologies, thereby permitting solution accuracy and resolving important flow physics in the seat region of the moving valve. An advantage to this software includes possible reduction in testing costs incurred due to disruptions relating to unexpected flow transients or functioning of valve/flow control systems. Prediction of the flow anomalies leading to system vibrations, flow resonance, and valve stall can help in valve scheduling and significantly reduce the need for activation tests. This framework has been evaluated for its ability to predict performance metrics like flow coefficient for cavitating venturis and valve coefficient curves, and could be a valuable tool in predicting and understanding anomalous behavior of system components at rocket propulsion testing and design sites.

  11. Network fingerprint: a knowledge-based characterization of biomedical networks

    OpenAIRE

    Xiuliang Cui; Haochen He; Fuchu He; Shengqi Wang; Fei Li; Xiaochen Bo

    2015-01-01

    It can be difficult for biomedical researchers to understand complex molecular networks due to their unfamiliarity with the mathematical concepts employed. To represent molecular networks with clear meanings and familiar forms for biomedical researchers, we introduce a knowledge-based computational framework to decipher biomedical networks by making systematic comparisons to well-studied “basic networks”. A biomedical network is characterized as a spectrum-like vector called “network fingerpr...

  12. Dependability problems of complex information systems

    CERN Document Server

    Zamojski, Wojciech

    2014-01-01

    This monograph presents original research results on selected problems of dependability in contemporary Complex Information Systems (CIS). The ten chapters are concentrated around the following three aspects: methods for modelling of the system and its components, tasks ? or in more generic and more adequate interpretation, functionalities ? accomplished by the system and conditions for their correct realization in the dynamic operational environment. While the main focus is on theoretical advances and roadmaps for implementations of new technologies, a?much needed forum for sharing of the bes

  13. Complex systems: features, similarity and connectivity

    CERN Document Server

    Comin, Cesar H; Silva, Filipi N; Amancio, Diego R; Rodrigues, Francisco A; Costa, Luciano da F

    2016-01-01

    The increasing interest in complex networks research has been a consequence of several intrinsic features of this area, such as the generality of the approach to represent and model virtually any discrete system, and the incorporation of concepts and methods deriving from many areas, from statistical physics to sociology, which are often used in an independent way. Yet, for this same reason, it would be desirable to integrate these various aspects into a more coherent and organic framework, which would imply in several benefits normally allowed by the systematization in science, including the identification of new types of problems and the cross-fertilization between fields. More specifically, the identification of the main areas to which the concepts frequently used in complex networks can be applied paves the way to adopting and applying a larger set of concepts and methods deriving from those respective areas. Among the several areas that have been used in complex networks research, pattern recognition, op...

  14. Complex Systems Design & Management : Proceedings of the Second International Conference on Complex Systems Design & Management

    CERN Document Server

    Krob, Daniel; Voirin, Jean-Luc

    2012-01-01

    This book contains all refereed papers that were accepted to the second edition of the « Complex Systems Design & Management » (CSDM 2011) international conference that took place in Paris (France) from December 7 to December 9, 2011. (Website: http://www.csdm2011.csdm.fr/). These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, e-services), scientific & technical topics (systems fundamentals, systems architecture& engineering, systems metrics & quality, systemic  tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSDM 2011 conference is organized under the guidance of the CESAMES non-profit organization (http://www.cesames.net/).

  15. Complex Systems Design & Management : Proceedings of the Third International Conference on Complex Systems Design & Management

    CERN Document Server

    Caseau, Yves; Krob, Daniel; Rauzy, Antoine

    2013-01-01

    This book contains all refereed papers that were accepted to the third edition of the « Complex Systems Design & Management » (CSD&M 2012) international conference that took place in Paris (France) from December 12-14, 2012. (Website: http://www.csdm2012.csdm.fr)  These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, e-services), scientific & technical topics (systems fundamentals, systems architecture& engineering, systems metrics & quality, systemic  tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSD&M 2012 conference is organized under the guidance of the CESAMES non-profit organization (http://www.cesames.net).

  16. Three-dimensional laser optoacoustic and laser ultrasound imaging system for biomedical research

    Science.gov (United States)

    Ermilov, Sergey A.; Su, Richard; Conjusteau, Andre; Oruganti, Tanmayi; Wang, Kun; Anis, Fatima; Anastasio, Mark A.; Oraevsky, Alexander A.

    2015-03-01

    In this work, we introduce an improved prototype of the imaging system that combines three-dimensional optoacoustic tomography (3D-OAT) and laser ultrasound tomography slicer (2D-LUT) to obtain coregistered maps of tissue optical absorption and speed of sound (SOS). The imaging scan is performed by a 360 degree rotation of a phantom/mouse with respect to a static arc-shaped array of ultrasonic transducers. A Q-switched laser system is used to establish optoacoustic illumination pattern appropriate for deep tissue imaging with a tunable (730-840 nm) output wavelengths operated at 10 Hz pulse repetition rate. For the LUT slicer scans, the array is pivoted by 90 degrees with respect to the central transducers providing accurate registration of optoacoustic and SOS maps, the latter being reconstructed using waveform inversion with source encoding (WISE) technique. The coregistered OAT-LUT modality is validated by imaging a phantom and a live mouse. SOS maps acquired in the imaging system can be employed by an iterative optoacoustic reconstruction algorithm capable of compensating for acoustic wavefield aberrations. The most promising applications of the imaging system include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents (carbon nanotubes, metal plasmonic nanoparticles, fluorophores, etc.).

  17. Combined confocal Raman and quantitative phase microscopy system for biomedical diagnosis

    OpenAIRE

    Kang, Jeon Woong; Lue, Niyom; Kong, Chae-Ryon; Barman, Ishan; Dingari, Narahara C.; Goldfless, Stephen J.; Niles, Jacquin C.; Dasari, Ramachandra R.; Michael S. Feld

    2011-01-01

    We have developed a novel multimodal microscopy system that incorporates confocal Raman, confocal reflectance, and quantitative phase microscopy (QPM) into a single imaging entity. Confocal Raman microscopy provides detailed chemical information from the sample, while confocal reflectance and quantitative phase microscopy show detailed morphology. Combining these intrinsic contrast imaging modalities makes it possible to obtain quantitative morphological and chemical information without exoge...

  18. Mid-infrared spectroscopic characterisation of an ultra-broadband tunable EC-QCL system intended for biomedical applications

    Science.gov (United States)

    Vahlsing, T.; Moser, H.; Grafen, M.; Nalpantidis, K.; Brandstetter, M.; Heise, H. M.; Lendl, B.; Leonhardt, S.; Ihrig, D.; Ostendorf, A.

    2015-07-01

    Mid-infrared spectroscopy has been successfully applied for reagent-free clinical chemistry applications. Our aim is to design a portable bed-side system for ICU patient monitoring, based on mid-infrared absorption spectra of continuously sampled body-fluids. Robust and miniature bed-side systems can be achieved with tunable external cavity quantum cascade lasers (EC-QCL). Previously, single EC-QCL modules covering a wavenumber interval up to 250 cm-1 have been utilized. However, for broader applicability in biomedical research an extended interval around the mid-infrared fingerprint region should be accessible, which is possible with at least three or four EC-QCL modules. For such purpose, a tunable ultra-broadband system (1920 - 780 cm-1, Block Engineering) has been studied with regard to its transient emission characteristics in ns time resolution during different laser pulse widths using a VERTEX 80v FTIR spectrometer with step-scan option. Furthermore, laser emission line profiles of all four incorporated EC-QCL modules have been analysed at high spectral resolution (0.08 cm-1) and beam profiles with few deviations from the TEM 00 spatial mode have been manifested. Emission line reproducibility has been tested for various wavenumbers in step tune mode. The overall accuracy of manufacturer default wavenumber setting has been found between ± 3 cm-1 compared to the FTIR spectrometer scale. With regard to an application in clinical chemistry, theoretically achievable concentration accuracies for different blood substrates based on blood plasma and dialysate spectra previously recorded by FTIRspectrometers have been estimated taking into account the now accessible extended wavenumber interval.

  19. Reliable and energy-efficient communications for wireless biomedical implant systems.

    Science.gov (United States)

    Ntouni, Georgia D; Lioumpas, Athanasios S; Nikita, Konstantina S

    2014-11-01

    Implant devices are used to measure biological parameters and transmit their results to remote off-body devices. As implants are characterized by strict requirements on size, reliability, and power consumption, applying the concept of cooperative communications to wireless body area networks offers several benefits. In this paper, we aim to minimize the power consumption of the implant device by utilizing on-body wearable devices, while providing the necessary reliability in terms of outage probability and bit error rate. Taking into account realistic power considerations and wireless propagation environments based on the IEEE P802.l5 channel model, an exact theoretical analysis is conducted for evaluating several communication scenarios with respect to the position of the wearable device and the motion of the human body. The derived closed-form expressions are employed toward minimizing the required transmission power, subject to a minimum quality-of-service requirement. In this way, the complexity and power consumption are transferred from the implant device to the on-body relay, which is an efficient approach since they can be easily replaced, in contrast to the in-body implants. PMID:25375682

  20. A Triple-Loop Inductive Power Transmission System for Biomedical Applications.

    Science.gov (United States)

    Lee, Byunghun; Kiani, Mehdi; Ghovanloo, Maysam

    2016-02-01

    A triple-loop wireless power transmission (WPT) system equipped with closed-loop global power control, adaptive transmitter (Tx) resonance compensation (TRC), and automatic receiver (Rx) resonance tuning (ART) is presented. This system not only opposes coupling and load variations but also compensates for changes in the environment surrounding the inductive link to enhance power transfer efficiency (PTE) in applications such as implantable medical devices (IMDs). The Tx was built around a commercial off-the-shelf (COTS) radio-frequency identification (RFID) reader, operating at 13.56 MHz. A local Tx loop finds the optimal capacitance in parallel with the Tx coil by adjusting a varactor. A global power control loop maintains the received power at a desired level in the presence of changes in coupling distance, coil misalignments, and loading. Moreover, a local Rx loop is implemented inside a power management integrated circuit (PMIC) to avoid PTE degradation due to the Rx coil surrounding environment and process variations. The PMIC was fabricated in a 0.35- μm 4M2P standard CMOS process with 2.54 mm(2) active area. Measurement results show that the proposed triple-loop system improves the overall PTE by up to 10.5% and 4.7% compared to a similar open- and single closed-loop system, respectively, at nominal coil distance of 2 cm. The added TRC and ART loops contribute 2.3% and 1.4% to the overall PTE of 13.5%, respectively. This is the first WPT system to include three loops to dynamically compensate for environment and circuit variations and improve the overall power efficiency all the way from the driver output in Tx to the load in Rx. PMID:25667358

  1. Multifractal Resilience Metrics for Complex Systems?

    Science.gov (United States)

    Schertzer, D. J.; Tchiguirinskaia, I.; Lovejoy, S.

    2011-12-01

    The term resilience has become extremely fashionable, especially for complex systems, whereas corresponding operational definitions have remained rather elusive (Carpenter et al. 2001). More precisely, the resilience assessment of man-made systems (from nuclear plants to cities) to geophysical extremes require mathematically defined resilience metrics based on some conceptual definition, e.g. the often cited definition of "ecological resilience" (Hollings 1973): "the capacity of a system to absorb disturbance and reorganize while undergoing change so as to still retain essentially the same function, structure, identity, and feedbacks". Surprisingly, whereas it was acknowledged by Folke et al. (2010) that "multiscale resilience is fundamental for understanding the interplay between persistence and change, adaptability and transformability", the relation between resilience and scaling has not been so much questioned, see however Peterson (2000). We argue that is rather indispensable to go well beyond the attractor approach (Pimm and Lawton 1977; Collings and Wollkind 1990;), as well as extensions (Martin et al., 2011) into the framework of the viability theory (Aubin 1991; Aubin et al. 2011). Indeed, both are rather limited to systems that are complex only in time. Scale symmetries are indeed indispensable to reduce the space-time complexity by defining scale independent observables, which are the singularities of the original, scale dependent fields. These singularities enable to define across-scale resilience, instead of resilience at a given scale.

  2. Development and eigenvalue calibration of an automated spectral Mueller matrix system for biomedical polarimetry

    Science.gov (United States)

    Purwar, Harsh; Soni, Jalpa; Lakhotia, Harshit; Chandel, Shubham; Banerjee, Chitram; Ghosh, Nirmalya

    2012-03-01

    We present a novel spectral Mueller matrix measurement system for both elastic and inelastic scattering (fluorescence) polarimetric measurements. The system comprises of a Xenon lamp as excitation source, a polarization state generator (PSG) and a polarization state analyzer (PSA) unit to generate and analyze polarization states required for 4 x 4 sample Mueller matrix measurements, coupled to a spectrometer for spectrally resolved (λ ~ 400 - 800 nm) signal detection. The PSG unit comprises of a fixed linear polarizer (polarization axis oriented at horizontal position) followed by a rotatable broadband quarter wave plate. The sample-scattered light is collected and collimated using an assembly of lenses, then passes through the PSA unit, and is finally recorded using the spectrometer. The PSA unit essentially consists of a similar arrangement as that of the PSG, but positioned in reverse order, and with the axis of the linear polarizer oriented at vertical position. A sequence of sixteen measurements are performed by changing the orientation of the fast axis of the quarter wave plates of the PSG unit (for generating the four required elliptical polarization states) and that of the PSA unit (for analyzing the corresponding polarization states). The orientation angles (35°, 70°, 105° and 140°) were chosen based on optimization of the PSG and PSA matrices to yield most stable system Mueller matrices. The performance of the polarimeter was calibrated using Eigenvalue calibration method which also yielded the actual values of the system PSG and PSA matrices at each wavelength. The system has been automated and is capable of Mueller matrix measurement with high accuracy over the entire spectral range 400 - 800 nm (elemental error PSG and PSA matrices for each wavelength are used, while for fluorescence Mueller matrix measurements, the PSG for the excitation wavelength (chosen to be 405 nm) and PSA for varying emission wavelengths (450 - 800 nm) are used. The

  3. A Novel Feature Selection Strategy for Enhanced Biomedical Event Extraction Using the Turku System

    Directory of Open Access Journals (Sweden)

    Jingbo Xia

    2014-01-01

    Full Text Available Feature selection is of paramount importance for text-mining classifiers with high-dimensional features. The Turku Event Extraction System (TEES is the best performing tool in the GENIA BioNLP 2009/2011 shared tasks, which relies heavily on high-dimensional features. This paper describes research which, based on an implementation of an accumulated effect evaluation (AEE algorithm applying the greedy search strategy, analyses the contribution of every single feature class in TEES with a view to identify important features and modify the feature set accordingly. With an updated feature set, a new system is acquired with enhanced performance which achieves an increased F-score of 53.27% up from 51.21% for Task 1 under strict evaluation criteria and 57.24% according to the approximate span and recursive criterion.

  4. A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging

    International Nuclear Information System (INIS)

    Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals. (author)

  5. Development of A Biomedical Imaging Informatics System for Diagnosis and Treatment Planning

    OpenAIRE

    Wang, Geoffrey; Wang, May D.

    2003-01-01

    The medical imaging technologies have been used for detecting tumors through the years. Tumors that can be viewed in imaging are usually big enough to contain billion tumor cells. Some patients may be cured if detected earlier and the surgery is performed well. Those lead to molecular imaging and image-guided surgery research activities, which post new challenges on large scale imaging data management and 3-D visualization. The goal of this project is to develop 3-D imaging informatics system...

  6. Biomedical Technology: The transforming paradigm of Healthcare Industry with its impact on Patient Monitoring System

    Directory of Open Access Journals (Sweden)

    Onkar S Kemkar

    2012-06-01

    Full Text Available Telehealth technology, which leverages wireless andenterprise networking, is changing the model of how we thinkabout going to the doctor. The ability to automatically andaccurately capture and record patient data from biomedicaldevices can improve workflow and efficiency. In this paperwe are going to discuss a patient monitoring system based onan existing industry standard communication network, usingstandard hardware components and software technologies.The standard interfaces, and flexible signal interpretationpotential.

  7. Biotechnological and biomedical applications of mesenchymal stem cells as a therapeutic system.

    Science.gov (United States)

    Rahimzadeh, Amirbahman; Tabatabaei Mirakabad, Fatemeh Sadat; Movassaghpour, Aliakbar; Shamsasenjan, Karim; Kariminekoo, Saber; Talebi, Mehdi; Shekari, Abolfazl; Zeighamian, Vahideh; Gandomkar Ghalhar, Masoud; Akbarzadeh, Abolfazl

    2016-03-01

    Mesenchymal stem cells (MSCs) are non-hematopoietic, multipotent progenitor cells which reside in bone marrow (BM), support homing of hematopoietic stem cells (HSCs) and self-renewal in the BM. These cells have the potential to differentiate into tissues of mesenchymal origin, such as fibroblasts, adipocytes, cardiomyocytes, and stromal cells. MSCs can express surface molecules like CD13, CD29, CD44, CD73, CD90, CD166, CXCL12 and toll-like receptors (TLRs). Different factors, such as TGF-β, IL-10, IDO, PGE-2, sHLA-G5, HO, and Galectin-3, secreted by MSCs, induce interaction in cell to cell immunomodulatory effects on innate and adaptive cells of the immune system. Furthermore, these cells can stimulate and increase the TH2 and regulatory T-cells through inhibitory effects on the immune system. MSCs originate from the BM and other tissues including the brain, adipose tissue, peripheral blood, cornea, thymus, spleen, fallopian tube, placenta, Wharton's jelly and umbilical cord blood. Many studies have focused on two significant features of MSC therapy: (I) MSCs can modulate T-cell-mediated immunological responses, and (II) systemically administered MSCs home in to sites of ischemia or injury. In this review, we describe the known mechanisms of immunomodulation and homing of MSCs. As a result, this review emphasizes the functional role of MSCs in modulating immune responses, their capability in homing to injured tissue, and their clinical therapeutic potential. PMID:25340260

  8. Biomedical Sensors and Instruments

    CERN Document Server

    Tagawa, Tatsuo

    2011-01-01

    The living body is a difficult object to measure: accurate measurements of physiological signals require sensors and instruments capable of high specificity and selectivity that do not interfere with the systems under study. As a result, detailed knowledge of sensor and instrument properties is required to be able to select the "best" sensor from one of the many designed to meet these challenges. From the underlying principles to practical applications, this updated edition of Biomedical Sensors and Instruments provides an easy-to-understand introduction to the various kinds of biome

  9. Principles of Biomedical Engineering

    CERN Document Server

    Madihally, Sundararajan V

    2010-01-01

    Describing the role of engineering in medicine today, this comprehensive volume covers a wide range of the most important topics in this burgeoning field. Supported with over 145 illustrations, the book discusses bioelectrical systems, mechanical analysis of biological tissues and organs, biomaterial selection, compartmental modeling, and biomedical instrumentation. Moreover, you find a thorough treatment of the concept of using living cells in various therapeutics and diagnostics.Structured as a complete text for students with some engineering background, the book also makes a valuable refere

  10. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1973-01-01

    Advances in Biomedical Engineering, Volume 2, is a collection of papers that discusses the basic sciences, the applied sciences of engineering, the medical sciences, and the delivery of health services. One paper discusses the models of adrenal cortical control, including the secretion and metabolism of cortisol (the controlled process), as well as the initiation and modulation of secretion of ACTH (the controller). Another paper discusses hospital computer systems-application problems, objective evaluation of technology, and multiple pathways for future hospital computer applications. The pos

  11. Advances in biomedical engineering

    CERN Document Server

    Brown, J H U

    1974-01-01

    Advances in Biomedical Engineering, Volume 4, is a collection of papers that deals with gas chromatography, mass spectroscopy and the analysis of minute samples, as well as the role of the government in regulating the production, usage, safety, and efficacy of medical devices. One paper reviews the use of mass spectrometry and computer technology in relation to gas-phase analytical methods based on gas chromatograph-mass spectrometer instruments and gas chromatograph-mass spectrometer-computer analytical systems. Many health practitioners, government and private health agencies, the legal prof

  12. Relaxation and Diffusion in Complex Systems

    CERN Document Server

    Ngai, K L

    2011-01-01

    Relaxation and Diffusion in Complex Systems comprehensively presents a variety of experimental evidences of universal relaxation and diffusion properties in complex materials and systems. The materials discussed include liquids, glasses, colloids, polymers, rubbers, plastic crystals and aqueous mixtures, as well as carbohydrates, biomolecules, bioprotectants and pharmaceuticals. Due to the abundance of experimental data, emphasis is placed on glass-formers and the glass transition problem, a still unsolved problem in condensed matter physics and chemistry. The evidence for universal properties of relaxation and diffusion dynamics suggests that a fundamental physical law is at work. The origin of the universal properties is traced to the many-body effects of the interaction, rigorous theory of which does not exist at the present time. However, using solutions of simplified models as guides, key quantities have been identified and predictions of the universal properties generated. These predictions from Ngai’...

  13. Analysis of complex systems using neural networks

    International Nuclear Information System (INIS)

    The application of neural networks, alone or in conjunction with other advanced technologies (expert systems, fuzzy logic, and/or genetic algorithms), to some of the problems of complex engineering systems has the potential to enhance the safety, reliability, and operability of these systems. Typically, the measured variables from the systems are analog variables that must be sampled and normalized to expected peak values before they are introduced into neural networks. Often data must be processed to put it into a form more acceptable to the neural network (e.g., a fast Fourier transformation of the time-series data to produce a spectral plot of the data). Specific applications described include: (1) Diagnostics: State of the Plant (2) Hybrid System for Transient Identification, (3) Sensor Validation, (4) Plant-Wide Monitoring, (5) Monitoring of Performance and Efficiency, and (6) Analysis of Vibrations. Although specific examples described deal with nuclear power plants or their subsystems, the techniques described can be applied to a wide variety of complex engineering systems

  14. Verification and Examination Management of Complex Systems

    Directory of Open Access Journals (Sweden)

    Stian Ruud

    2014-10-01

    Full Text Available As ship systems become more complex, with an increasing number of safety-critical functions, many interconnected subsystems, tight integration to other systems, and a large amount of potential failure modes, several industry parties have identified the need for improved methods for managing the verification and examination efforts of such complex systems. Such needs are even more prominent now that the marine and offshore industries are targeting more activities and operations in the Arctic environment. In this paper, a set of requirements and a method for verification and examination management are proposed for allocating examination efforts to selected subsystems. The method is based on a definition of a verification risk function for a given system topology and given requirements. The marginal verification risks for the subsystems may then be evaluated, so that examination efforts for the subsystem can be allocated. Two cases of requirements and systems are used to demonstrate the proposed method. The method establishes a systematic relationship between the verification loss, the logic system topology, verification method performance, examination stop criterion, the required examination effort, and a proposed sequence of examinations to reach the examination stop criterion.

  15. Complex Systems and Self-organization Modelling

    CERN Document Server

    Bertelle, Cyrille; Kadri-Dahmani, Hakima

    2009-01-01

    The concern of this book is the use of emergent computing and self-organization modelling within various applications of complex systems. The authors focus their attention both on the innovative concepts and implementations in order to model self-organizations, but also on the relevant applicative domains in which they can be used efficiently. This book is the outcome of a workshop meeting within ESM 2006 (Eurosis), held in Toulouse, France in October 2006.

  16. Stochastic Physics, Complex Systems and Biology

    OpenAIRE

    Qian, Hong

    2012-01-01

    In complex systems, the interplay between nonlinear and stochastic dynamics, e.g., J. Monod's necessity and chance, gives rise to an evolutionary process in Darwinian sense, in terms of discrete jumps among attractors, with punctuated equilibrium, spontaneous random "mutations" and "adaptations". On an evlutionary time scale it produces sustainable diversity among individuals in a homogeneous population rather than convergence as usually predicted by a deterministic dynamics. The emergent dis...

  17. Metadata queries for complex database systems

    OpenAIRE

    O'Connor, Gerald

    2004-01-01

    Federated Database Management Systems (FDBS) are very complex. Component databases can be heterogeneous, autonomous and distributed, accounting for these different characteristics in building a FDBS is a difficult engineering problem. The Common Data Model (CDM) is what is used to represent the data in the FDBS. It must be semantically rich to correctly represent the data from diverse component databases which differ in structure, datamodel, semantics and content. In this research project we ...

  18. FRAM Modelling Complex Socio-technical Systems

    CERN Document Server

    Hollnagel, Erik

    2012-01-01

    There has not yet been a comprehensive method that goes behind 'human error' and beyond the failure concept, and various complicated accidents have accentuated the need for it. The Functional Resonance Analysis Method (FRAM) fulfils that need. This book presents a detailed and tested method that can be used to model how complex and dynamic socio-technical systems work, and understand both why things sometimes go wrong but also why they normally succeed.

  19. Biomedical Imaging Principles and Applications

    CERN Document Server

    Salzer, Reiner

    2012-01-01

    This book presents and describes imaging technologies that can be used to study chemical processes and structural interactions in dynamic systems, principally in biomedical systems. The imaging technologies, largely biomedical imaging technologies such as MRT, Fluorescence mapping, raman mapping, nanoESCA, and CARS microscopy, have been selected according to their application range and to the chemical information content of their data. These technologies allow for the analysis and evaluation of delicate biological samples, which must not be disturbed during the profess. Ultimately, this may me

  20. Complex Engineered Systems: A New Paradigm

    Science.gov (United States)

    Mina, Ali A.; Braha, Dan; Bar-Yam, Yaneer

    Human history is often seen as an inexorable march towards greater complexity — in ideas, artifacts, social, political and economic systems, technology, and in the structure of life itself. While we do not have detailed knowledge of ancient times, it is reasonable to conclude that the average resident of New York City today faces a world of much greater complexity than the average denizen of Carthage or Tikal. A careful consideration of this change, however, suggests that most of it has occurred recently, and has been driven primarily by the emergence of technology as a force in human life. In the 4000 years separating the Indus Valley Civilization from 18th century Europe, human transportation evolved from the bullock cart to the hansom, and the methods of communication used by George Washington did not differ significantly from those used by Alexander or Rameses. The world has moved radically towards greater complexity in the last two centuries. We have moved from buggies and letter couriers to airplanes and the Internet — an increase in capacity, and through its diversity also in complexity, orders of magnitude greater than that accumulated through the rest of human history. In addition to creating iconic artifacts — the airplane, the car, the computer, the television, etc. — this change has had a profound effect on the scope of experience by creating massive, connected and multiultra- level systems — traffic networks, power grids, markets, multinational corporations — that defy analytical understanding and seem to have a life of their own. This is where complexity truly enters our lives.

  1. A System for Automated Acquisition of 3D Biomedical Images Using Confocal Microscopy

    Czech Academy of Sciences Publication Activity Database

    Čapek, Martin; Tomori, Z.; Michálek, Jan; Janáček, Jiří; Kubínová, Lucie; Hozman, J.

    Vol.2. Graz: Verlag der Technischen Universität, 2009 - (Pabst, M.; Zellnig, G.), s. 415-416 ISBN 978-3-85125-062-6. [MC 2009 - Joint Meeting of Dreiländertagung and Multinational Congress on Microscopy /9./. Graz (AT), 30.08.2009-04.09.2009] R&D Projects: GA MŠk(CZ) LC06063; GA ČR(CZ) GA102/08/0691; GA ČR(CZ) GA304/09/0733; GA AV ČR(CZ) IAA100110502; GA MŠk(CZ) MEB080831 Grant ostatní: VEGA(SK) 2-0164-07 Institutional research plan: CEZ:AV0Z50110509 Keywords : confocal laser scanning microscope * illumination inhomogeneity * automated acquisition system Subject RIV: JD - Computer Applications, Robotics

  2. A System for Computing Conceptual Pathways in Bio-medical Text Models

    DEFF Research Database (Denmark)

    Andreasen, Troels; Bulskov, Henrik; Nilsson, Jørgen Fischer;

    2014-01-01

    -algebraic form of predicate logic. Natural logics are distinguished by coming close to natural language so that propositions are readable by domain experts. The natural logic knowledge base is accompanied by an internal graph representation, where the nodes represent simple concept terms as well as compound......This paper describes the key principles in a system for querying and conceptual path finding in a logic-based knowledge base. The knowledge base is extracted from textual descriptions in bio-, pharma- and medical areas. The knowledge base applies natural logic, that is, a variable-free term...... concepts stemming from entire phrases. Path finding between concepts is facilitated by a labelled graph form that represents the knowledge base as well as the ontological information....

  3. Life: An Introduction to Complex Systems Biology

    CERN Document Server

    Kaneko, Kunihiko

    2006-01-01

    What is life? Has molecular biology given us a satisfactory answer to this question? And if not, why, and how to carry on from there? This book examines life not from the reductionist point of view, but rather asks the question: what are the universal properties of living systems and how can one construct from there a phenomenological theory of life that leads naturally to complex processes such as reproductive cellular systems, evolution and differentiation? The presentation has been deliberately kept fairly non-technical so as to address a broad spectrum of students and researchers from the natural sciences and informatics.

  4. Chaos from simple models to complex systems

    CERN Document Server

    Cencini, Massimo; Vulpiani, Angelo

    2010-01-01

    Chaos: from simple models to complex systems aims to guide science and engineering students through chaos and nonlinear dynamics from classical examples to the most recent fields of research. The first part, intended for undergraduate and graduate students, is a gentle and self-contained introduction to the concepts and main tools for the characterization of deterministic chaotic systems, with emphasis to statistical approaches. The second part can be used as a reference by researchers as it focuses on more advanced topics including the characterization of chaos with tools of information theor

  5. Complexity for Survival of Living Systems

    Science.gov (United States)

    Zak, Michail

    2009-01-01

    A logical connection between the survivability of living systems and the complexity of their behavior (equivalently, mental complexity) has been established. This connection is an important intermediate result of continuing research on mathematical models that could constitute a unified representation of the evolution of both living and non-living systems. Earlier results of this research were reported in several prior NASA Tech Briefs articles, the two most relevant being Characteristics of Dynamics of Intelligent Systems (NPO- 21037), NASA Tech Briefs, Vol. 26, No. 12 (December 2002), page 48; and Self-Supervised Dynamical Systems (NPO- 30634) NASA Tech Briefs, Vol. 27, No. 3 (March 2003), page 72. As used here, living systems is synonymous with active systems and intelligent systems. The quoted terms can signify artificial agents (e.g., suitably programmed computers) or natural biological systems ranging from single-cell organisms at one extreme to the whole of human society at the other extreme. One of the requirements that must be satisfied in mathematical modeling of living systems is reconciliation of evolution of life with the second law of thermodynamics. In the approach followed in this research, this reconciliation is effected by means of a model, inspired partly by quantum mechanics, in which the quantum potential is replaced with an information potential. The model captures the most fundamental property of life - the ability to evolve from disorder to order without any external interference. The model incorporates the equations of classical dynamics, including Newton s equations of motion and equations for random components caused by uncertainties in initial conditions and by Langevin forces. The equations of classical dynamics are coupled with corresponding Liouville or Fokker-Planck equations that describe the evolutions of probability densities that represent the uncertainties. The coupling is effected by fictitious information-based forces that are

  6. Nanodiamonds as novel nanomaterials for biomedical applications: drug delivery and imaging systems

    Directory of Open Access Journals (Sweden)

    Kaur R

    2013-01-01

    Full Text Available Randeep Kaur, Ildiko BadeaDrug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaAbstract: Detonation nanodiamonds (NDs are emerging as delivery vehicles for small chemical drugs and macromolecular biotechnology products due to their primary particle size of 4 to 5 nm, stable inert core, reactive surface, and ability to form hydrogels. Nanoprobe technology capitalizes on the intrinsic fluorescence, high refractive index, and unique Raman signal of the NDs, rendering them attractive for in vitro and in vivo imaging applications. This review provides a brief introduction of the various types of NDs and describes the development of procedures that have led to stable single-digit-sized ND dispersions, a crucial feature for drug delivery systems and nanoprobes. Various approaches used for functionalizing the surface of NDs are highlighted, along with a discussion of their biocompatibility status. The utilization of NDs to provide sustained release and improve the dispersion of hydrophobic molecules, of which chemotherapeutic drugs are the most investigated, is described. The prospects of improving the intracellular delivery of nucleic acids by using NDs as a platform are exemplified. The photoluminescent and optical scattering properties of NDs, together with their applications in cellular labeling, are also reviewed. Considering the progress that has been made in understanding the properties of NDs, they can be envisioned as highly efficient drug delivery and imaging biomaterials for use in animals and humans.Keywords: dispersion, surface functionalization, toxicity, carriers, fluorescence, light scattering

  7. System architecture and information model for integrated access to distributed biomedical information

    Science.gov (United States)

    Kim, Dongkyu; Alaoui, Adil; Levine, Betty; Leondaridis, Leonidas; Shields, Peter; Byers, Steve; Cleary, Kevin

    2009-02-01

    The current trend towards systems medicine will rely heavily on computational and bioinformatics capabilities to collect, integrate, and analyze massive amounts of data from disparate sources. The objective is to use this information to make medical decisions that improve patient care. At Georgetown University Medical Center, we are developing an informatics capability to integrate several research and clinical databases. Our long term goal is to provide researchers at Georgetown's Lombardi Comprehensive Cancer Center better access to aggregated molecular and clinical information facilitating the investigation of new hypotheses that impact patient care. We also recognize the need for data mining tools and intelligent agents to help researchers in these efforts. This paper describes our initial work to create a flexible platform for researchers and physicians that provides access to information sources including clinical records, medical images, genomic, epigenomic, proteomic and metabolomic data. This paper describes the data sources selected for this pilot project and possible approaches to integrating these databases. We present the different database integration models that we considered. We conclude by outlining the proposed Information Model for the project.

  8. Complex Generalized Synchronization and Parameter Identification of Nonidentical Nonlinear Complex Systems.

    Directory of Open Access Journals (Sweden)

    Shibing Wang

    Full Text Available In this paper, generalized synchronization (GS is extended from real space to complex space, resulting in a new synchronization scheme, complex generalized synchronization (CGS. Based on Lyapunov stability theory, an adaptive controller and parameter update laws are designed to realize CGS and parameter identification of two nonidentical chaotic (hyperchaotic complex systems with respect to a given complex map vector. This scheme is applied to synchronize a memristor-based hyperchaotic complexsystem and a memristor-based chaotic complex Lorenz system, a chaotic complex Chen system and a memristor-based chaotic complex Lorenz system, as well as a memristor-based hyperchaotic complexsystem and a chaotic complexsystem with fully unknown parameters. The corresponding numerical simulations illustrate the feasibility and effectiveness of the proposed scheme.

  9. Complex Generalized Synchronization and Parameter Identification of Nonidentical Nonlinear Complex Systems.

    Science.gov (United States)

    Wang, Shibing; Wang, Xingyuan; Han, Bo

    2016-01-01

    In this paper, generalized synchronization (GS) is extended from real space to complex space, resulting in a new synchronization scheme, complex generalized synchronization (CGS). Based on Lyapunov stability theory, an adaptive controller and parameter update laws are designed to realize CGS and parameter identification of two nonidentical chaotic (hyperchaotic) complex systems with respect to a given complex map vector. This scheme is applied to synchronize a memristor-based hyperchaotic complexsystem and a memristor-based chaotic complex Lorenz system, a chaotic complex Chen system and a memristor-based chaotic complex Lorenz system, as well as a memristor-based hyperchaotic complexsystem and a chaotic complexsystem with fully unknown parameters. The corresponding numerical simulations illustrate the feasibility and effectiveness of the proposed scheme. PMID:27014879

  10. Investigating combination HIV prevention: isolated interventions or complex system

    Directory of Open Access Journals (Sweden)

    Graham Brown

    2015-12-01

    Full Text Available Introduction: Treatment as prevention has mobilized new opportunities in preventing HIV transmission and has led to bold new UNAIDS targets in testing, treatment coverage and transmission reduction. These will require not only an increase in investment but also a deeper understanding of the dynamics of combining behavioural, biomedical and structural HIV prevention interventions. High-income countries are making substantial investments in combination HIV prevention, but is this investment leading to a deeper understanding of how to combine interventions? The combining of interventions involves complexity, with many strategies interacting with non-linear and multiplying rather than additive effects. Discussion: Drawing on a recent scoping study of the published research evidence in HIV prevention in high-income countries, this paper argues that there is a gap between the evidence currently available and the evidence needed to guide the achieving of these bold targets. The emphasis of HIV prevention intervention research continues to look at one intervention at a time in isolation from its interactions with other interventions, the community and the socio-political context of their implementation. To understand and evaluate the role of a combination of interventions, we need to understand not only what works, but in what circumstances, what role the parts need to play in their relationship with each other, when the combination needs to adapt and identify emergent effects of any resulting synergies. There is little development of evidence-based indicators on how interventions in combination should achieve that strategic advantage and synergy. This commentary discusses the implications of this ongoing situation for future research and the required investment in partnership. We suggest that systems science approaches, which are being increasingly applied in other areas of public health, could provide an expanded vocabulary and analytic tools for

  11. Simulating Complex Systems by Cellular Automata

    CERN Document Server

    Kroc, Jiri; Hoekstra, Alfons G

    2010-01-01

    Deeply rooted in fundamental research in Mathematics and Computer Science, Cellular Automata (CA) are recognized as an intuitive modeling paradigm for Complex Systems. Already very basic CA, with extremely simple micro dynamics such as the Game of Life, show an almost endless display of complex emergent behavior. Conversely, CA can also be designed to produce a desired emergent behavior, using either theoretical methodologies or evolutionary techniques. Meanwhile, beyond the original realm of applications - Physics, Computer Science, and Mathematics – CA have also become work horses in very different disciplines such as epidemiology, immunology, sociology, and finance. In this context of fast and impressive progress, spurred further by the enormous attraction these topics have on students, this book emerges as a welcome overview of the field for its practitioners, as well as a good starting point for detailed study on the graduate and post-graduate level. The book contains three parts, two major parts on th...

  12. 生物医学传感器与医疗保健系统的发展趋势%Developing Trends of Biomedical Sensors and Healthcare System

    Institute of Scientific and Technical Information of China (English)

    陈鲁英; 刘忠国; 刘伯强

    2011-01-01

    生物医学传感器是高质量、低成本的卫生保健系统发展的主要驱动力.以智能生物医学衣服、无损检测传感器、吞服式智能药丸、植入式传感器、无线传感器等为例介绍了生物医学传感器的发展趋势,指出它的发展方向是低成本、低功耗、微型化、智能化、多功能化、无损检测、远程供电、无线传输和采用高级功能生物相客材料,并对未来卫生保健系统的发展进行了展望.%With the upcoming aging population, it will be important to offer high-quality cost-effective health care services to them. Monitoring, diagnostics and therapy will become much more closely coupled than it is now. Thus, development of biomedical sensors technology will be crucial. With the increasing of hospital cost, the need for home care is expected to increase drastically, which will necessitate an increased use of simple sensors for health status monitoring and early detection. This will prevent diseases and will shorten hospital stays and contribute to a better life quality. Biomedical sensors will be one of the main driving forces for a high quality cost effective healthcare system. Future biomedical sensors will be low -cost, low -power, miniature, intelligent, invasive and multifunctional. Future biomedical sensors require technology of remote power generation and wireless communication with advanced functional and biocompatible materials. Intelligent biomedical clothes, invasive sensors, implantable sensors, smart pill, wireless monitoring, etc are taken as the examples to explain the prospect of biomedical sensor.[Chinese Medical Equipment Journal,2011,32(12) :90-92,109

  13. Recent developments in intelligent biomedical polymers

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Intelligent polymers or stimuli-responsive polymers may exhibit distinct transitions in physical-chemical properties, including conformation, polarity, phase structure and chemical composition in response to changes in environmental stimuli. Due to their unique ’intelligent’ characteristics, stimuli-sensitive polymers have found a wide variety of applications in biomedical and nanotechnological fields. This review focuses on the recent developments in biomedical application of intelligent polymer systems, such as intelligent hydrogel systems, intelligent drug delivery systems and intelligent molecular recognition systems. Also, the possible future directions for the application of these intelligent polymer systems in the biomedical field are presented.

  14. Ensemble annealing of complex physical systems

    CERN Document Server

    Habeck, Michael

    2015-01-01

    Algorithms for simulating complex physical systems or solving difficult optimization problems often resort to an annealing process. Rather than simulating the system at the temperature of interest, an annealing algorithm starts at a temperature that is high enough to ensure ergodicity and gradually decreases it until the destination temperature is reached. This idea is used in popular algorithms such as parallel tempering and simulated annealing. A general problem with annealing methods is that they require a temperature schedule. Choosing well-balanced temperature schedules can be tedious and time-consuming. Imbalanced schedules can have a negative impact on the convergence, runtime and success of annealing algorithms. This article outlines a unifying framework, ensemble annealing, that combines ideas from simulated annealing, histogram reweighting and nested sampling with concepts in thermodynamic control. Ensemble annealing simultaneously simulates a physical system and estimates its density of states. The...

  15. Orbit equivalent substitution dynamical systems and complexity

    CERN Document Server

    Bezuglyi, S

    2012-01-01

    For any primitive proper substitution \\sigma, we give explicit constructions of countably many pairwise non-isomorphic substitution dynamical systems {(X_{\\zeta_n}, T_{\\zeta_n})}_{n=1}^{\\infty} such that they all are (strong) orbit equivalent to (X_{\\sigma}, T_{\\sigma}). We show that the complexity of the substitution dynamical systems {(X_{\\zeta_n}, T_{\\zeta_n})} is essentially different that prevents them from being isomorphic. Given a primitive (not necessarily proper) substitution \\tau, we find a stationary simple properly ordered Bratteli diagram with the least possible number of vertices such that the corresponding Bratteli-Vershik system is orbit equivalent to (X_{\\tau}, T_{\\tau}).

  16. Optimal exploitation of complex electric energy systems

    International Nuclear Information System (INIS)

    One of the possible manners, to reduce the losses in consumption of electrical energy in Complex Electro-energetic Systems is inventing of optimal solution on a lot of problems which exists in exploitation of CEES (Complexual Electro-energetic Systems), as so as in theirs starting that and in theirs exploitation in CEES, independent of consumption in EPS (Electric Power System). In all this very important is the insuring of optimal exploitation of Power Plants with minimal economic deficit and minimal energetic deficit. In this paper will be proposed concrete example of exploitation of two Power Plants, which one of them is Thermal Power Plant and the other is Hydro Power Plant, and by the way was calculated their necessary optimal working time independent of consumption in Power Grids. It is analyzed regular using of Primary energetic sources in exploitation of Thermal and Hydro Power Plants with maximal saving water in HPP and maximal saving fossil fuel in TPP. (Author)

  17. Simulating Complex Window Systems using BSDF Data

    Energy Technology Data Exchange (ETDEWEB)

    Konstantoglou, Maria; Jonsson, Jacob; Lee, Eleanor

    2009-06-22

    Nowadays, virtual models are commonly used to evaluate the performance of conventional window systems. Complex fenestration systems can be difficult to simulate accurately not only because of their geometry but also because of their optical properties that scatter light in an unpredictable manner. Bi-directional Scattering Distribution Functions (BSDF) have recently been developed based on a mixture of measurements and modelling to characterize the optics of such systems. This paper describes the workflow needed to create then use these BSDF datasets in the Radiance lighting simulation software. Limited comparisons are made between visualizations produced using the standard ray-tracing method, the BSDF method, and that taken in a full-scale outdoor mockup.

  18. Supervisory control for a complex robotic system

    International Nuclear Information System (INIS)

    The Robotic Radiation Survey and Analysis System investigates the use of advanced robotic technology for performing remote radiation surveys on nuclear waste shipping casks. Robotic systems have the potential for reducing personnel exposure to radiation and providing fast reliable throughput at future repository sites. A primary technology issue is the integrated control of distributed specialized hardware through a modular supervisory software system. Automated programming of robot trajectories based upon mathematical models of the cask and robot coupled with sensory feedback enables flexible operation of a commercial gantry robot with the reliability needed to perform autonomous operations in a hazardous environment. Complexity is managed using structured software engineering techniques resulting in the generation of reusable command primitives which contribute to a software parts catalog for a generalized robot programming language

  19. Nanostructured, complex hydride systems for hydrogen generation

    Directory of Open Access Journals (Sweden)

    Robert A. Varin

    2015-02-01

    Full Text Available Complex hydride systems for hydrogen (H2 generation for supplying fuel cells are being reviewed. In the first group, the hydride systems that are capable of generating H2 through a mechanical dehydrogenation phenomenon at the ambient temperature are discussed. There are few quite diverse systems in this group such as lithium alanate (LiAlH4 with the following additives: nanoiron (n-Fe, lithium amide (LiNH2 (a hydride/hydride system and manganese chloride MnCl2 (a hydride/halide system. Another hydride/hydride system consists of lithium amide (LiNH2 and magnesium hydride (MgH2, and finally, there is a LiBH4-FeCl2 (hydride/halide system. These hydride systems are capable of releasing from ~4 to 7 wt.% H2 at the ambient temperature during a reasonably short duration of ball milling. The second group encompasses systems that generate H2 at slightly elevated temperature (up to 100 °C. In this group lithium alanate (LiAlH4 ball milled with the nano-Fe and nano-TiN/TiC/ZrC additives is a prominent system that can relatively quickly generate up to 7 wt.% H2 at 100 °C. The other hydride is manganese borohydride (Mn(BH42 obtained by mechano-chemical activation synthesis (MCAS. In a ball milled (2LiBH4 + MnCl2 nanocomposite, Mn(BH42 co-existing with LiCl can desorb ~4.5 wt.% H2 at 100 °C within a reasonable duration of dehydrogenation. Practical application aspects of hydride systems for H2 generation/storage are also briefly discussed.

  20. Modular interdependency in complex dynamical systems.

    Science.gov (United States)

    Watson, Richard A; Pollack, Jordan B

    2005-01-01

    Herbert A. Simon's characterization of modularity in dynamical systems describes subsystems as having dynamics that are approximately independent of those of other subsystems (in the short term). This fits with the general intuition that modules must, by definition, be approximately independent. In the evolution of complex systems, such modularity may enable subsystems to be modified and adapted independently of other subsystems, whereas in a nonmodular system, modifications to one part of the system may result in deleterious side effects elsewhere in the system. But this notion of modularity and its effect on evolvability is not well quantified and is rather simplistic. In particular, modularity need not imply that intermodule dependences are weak or unimportant. In dynamical systems this is acknowledged by Simon's suggestion that, in the long term, the dynamical behaviors of subsystems do interact with one another, albeit in an "aggregate" manner--but this kind of intermodule interaction is omitted in models of modularity for evolvability. In this brief discussion we seek to unify notions of modularity in dynamical systems with notions of how modularity affects evolvability. This leads to a quantifiable measure of modularity and a different understanding of its effect on evolvability. PMID:16197673

  1. BIG: a Grid Portal for Biomedical Data and Images

    OpenAIRE

    Giovanni Aloisio; Maria Cristina Barba; Euro Blasi; Massimo Cafaro; Sandro Fiore; Maria Mirto

    2004-01-01

    Modern management of biomedical systems involves the use of many distributed resources, such as high performance computational resources to analyze biomedical data, mass storage systems to store them, medical instruments (microscopes, tomographs, etc.), advanced visualization and rendering tools. Grids offer the computational power, security and availability needed by such novel applications. This paper presents BIG (Biomedical Imaging Grid), a Web-based Grid portal for management of biomedic...

  2. Biomedical technology

    CERN Document Server

    Wriggers, Peter

    2015-01-01

    During the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types o...

  3. Nonlinear Dynamics, Chaotic and Complex Systems

    Science.gov (United States)

    Infeld, E.; Zelazny, R.; Galkowski, A.

    2011-04-01

    Part I. Dynamic Systems Bifurcation Theory and Chaos: 1. Chaos in random dynamical systems V. M. Gunldach; 2. Controlling chaos using embedded unstable periodic orbits: the problem of optimal periodic orbits B. R. Hunt and E. Ott; 3. Chaotic tracer dynamics in open hydrodynamical flows G. Karolyi, A. Pentek, T. Tel and Z. Toroczkai; 4. Homoclinic chaos L. P. Shilnikov; Part II. Spatially Extended Systems: 5. Hydrodynamics of relativistic probability flows I. Bialynicki-Birula; 6. Waves in ionic reaction-diffusion-migration systems P. Hasal, V. Nevoral, I. Schreiber, H. Sevcikova, D. Snita, and M. Marek; 7. Anomalous scaling in turbulence: a field theoretical approach V. Lvov and I. Procaccia; 8. Abelian sandpile cellular automata M. Markosova; 9. Transport in an incompletely chaotic magnetic field F. Spineanu; Part III. Dynamical Chaos Quantum Physics and Foundations Of Statistical Mechanics: 10. Non-equilibrium statistical mechanics and ergodic theory L. A. Bunimovich; 11. Pseudochaos in statistical physics B. Chirikov; 12. Foundations of non-equilibrium statistical mechanics J. P. Dougherty; 13. Thermomechanical particle simulations W. G. Hoover, H. A. Posch, C. H. Dellago, O. Kum, C. G. Hoover, A. J. De Groot and B. L. Holian; 14. Quantum dynamics on a Markov background and irreversibility B. Pavlov; 15. Time chaos and the laws of nature I. Prigogine and D. J. Driebe; 16. Evolutionary Q and cognitive systems: dynamic entropies and predictability of evolutionary processes W. Ebeling; 17. Spatiotemporal chaos information processing in neural networks H. Szu; 18. Phase transitions and learning in neural networks C. Van den Broeck; 19. Synthesis of chaos A. Vanecek and S. Celikovsky; 20. Computational complexity of continuous problems H. Wozniakowski; Part IV. Complex Systems As An Interface Between Natural Sciences and Environmental Social and Economic Sciences: 21. Stochastic differential geometry in finance studies V. G. Makhankov; Part V. Conference Banquet

  4. Combination-Combination Hyperchaos Synchronization of Complex Memristor Oscillator System

    OpenAIRE

    Zhang Jin-E

    2014-01-01

    The combination-combination synchronization scheme is based on combination of multidrive systems and combination of multiresponse systems. In this paper, we investigate combination-combination synchronization of hyperchaotic complex memristor oscillator system. Several sufficient conditions are provided to ascertain the combination of two drive hyperchaotic complex memristor oscillator systems to synchronize the combination of two response hyperchaotic complex memristor oscillator systems. Th...

  5. Complex Adaptive Digital EcoSystems

    CERN Document Server

    Briscoe, Gerard

    2011-01-01

    We investigate an abstract conceptualisation of DigitalEcosystems from a computer science perspective. We then provide a conceptual framework for the cross pollination of ideas, concepts and understanding between different classes of ecosystems through the universally applicable principles of Complex Adaptive Systems (CAS) modelling. A framework to assist the cross-disciplinary collaboration of research into Digital Ecosystems, including Digital BusinessEcosystems (DBEs) and Digital Knowledge Ecosystems (DKEs). So, we have defined the key steps towards a theoretical framework for Digital Ecosystems, that is compatible with the diverse theoretical views prevalent. Therefore, a theoretical edifice that can unify the diverse efforts within Digital Ecosystems research.

  6. Abstraction in artificial intelligence and complex systems

    CERN Document Server

    Saitta, Lorenza

    2013-01-01

    Abstraction is a fundamental mechanism underlying both human and artificial perception, representation of knowledge, reasoning and learning. This mechanism plays a crucial role in many disciplines, notably Computer Programming, Natural and Artificial Vision, Complex Systems, Artificial Intelligence and Machine Learning, Art, and Cognitive Sciences. This book first provides the reader with an overview of the notions of abstraction proposed in various disciplines by comparing both commonalities and differences.  After discussing the characterizing properties of abstraction, a formal model, the K

  7. Complex Fluids in Energy Dissipating Systems

    Directory of Open Access Journals (Sweden)

    Francisco J. Galindo-Rosales

    2016-07-01

    Full Text Available The development of engineered systems for energy dissipation (or absorption during impacts or vibrations is an increasing need in our society, mainly for human protection applications, but also for ensuring the right performance of different sort of devices, facilities or installations. In the last decade, new energy dissipating composites based on the use of certain complex fluids have flourished, due to their non-linear relationship between stress and strain rate depending on the flow/field configuration. This manuscript intends to review the different approaches reported in the literature, analyses the fundamental physics behind them and assess their pros and cons from the perspective of their practical applications.

  8. Metaheuristics progress in complex systems optimization

    CERN Document Server

    Doerner, Karl F; Greistorfer, Peter; Gutjahr, Walter; Hartl, Richard F; Reimann, Marc

    2007-01-01

    The aim of ""Metaheuristics: Progress in Complex Systems Optimization"" is to provide several different kinds of information: a delineation of general metaheuristics methods, a number of state-of-the-art articles from a variety of well-known classical application areas as well as an outlook to modern computational methods in promising new areas. Therefore, this book may equally serve as a textbook in graduate courses for students, as a reference book for people interested in engineering or social sciences, and as a collection of new and promising avenues for researchers working in this field.

  9. Integrative Systems Biology: Elucidating Complex Traits

    DEFF Research Database (Denmark)

    Pers, Tune Hannes

    human traits and disease. e esis is structured as follows. Chapter  presents a few introductory remarks to integrative systems biology, and Chapter  gives a brief description of human genetic variation and GWA analysis. Chapters - present the main topics in the esis (integrative methodologies for...... body-mass index associated gene products coalesce onto distinct protein complexes, and show that these putative risk modules incriminate novel candidate obesitysusceptibility genes. e last overall line of research presented here, provides examples on how networks of human metabolism may serve as a...

  10. Ultrametricity in the theory of complex systems

    Science.gov (United States)

    Kozyrev, S. V.

    2015-11-01

    We review applications of p-adic and ultrametric methods in the theory of complex systems. We consider the following examples: the p-adic parameterization of the Parisi matrix in the replica method; the method of hierarchical (interbasin) kinetics, which allows describing macromolecular dynamics by models of ultrametric diffusion; the two-dimensional 2-adic parameterization of the genetic code, which demonstrates that degenerations of the genetic code are described by local constancy domains of maps in the 2-adic metric. We discuss clustering methods for a family of metrics and demonstrate that the multiclustering (ensemble clustering) approach is related to the Bruhat-Tits building theory.

  11. Modelling problems in complex systems dynamics

    International Nuclear Information System (INIS)

    The research deals with different aspects of mathematical modelling and the analysis of complex dynamic non-linear systems as a consequence of applied problems in mechanics (in particular those for gyrosystems, for stabilization and orientation systems, control systems of movable objects, including the aviation and aerospace systems) Non-linearity, multi-connectedness and high dimensionness of dynamical problems, that occur at the initial full statement lead to the need of the problem narrowing, and of the decomposition of the full model, but with safe-keeping of main properties and of qualitative equivalence. The elaboration of regular methods for modelling problems in dynamics, the generalization of reduction principle are the main aims of the investigations. Here, uniform methodology, based on Lyapunov's methods, founded by N.G.Ohetayev, is developed. The objects of the investigations are considered with exclusive positions, as systems of singularly perturbed class, treated as ones with singular parametrical perturbations. It is the natural extension of the statements of N.G.Chetayev and P.A.Kuzmin for parametrical stability. In paper the systematical procedures for construction of correct simplified models (comparison ones) are developed, the validity conditions of the transition are determined the appraisals are received, the regular algorithms of engineering level are obtained. Applicabilitelly to the stabilization and orientation systems with the gyroscopic controlling subsystems, these methods enable to build the hierarchical sequence of admissible simplified models; to determine the conditions of their correctness

  12. Assessment Environment for Complex Systems Software Guide

    Science.gov (United States)

    2013-01-01

    This Software Guide (SG) describes the software developed to test the Assessment Environment for Complex Systems (AECS) by the West Virginia High Technology Consortium (WVHTC) Foundation's Mission Systems Group (MSG) for the National Aeronautics and Space Administration (NASA) Aeronautics Research Mission Directorate (ARMD). This software is referred to as the AECS Test Project throughout the remainder of this document. AECS provides a framework for developing, simulating, testing, and analyzing modern avionics systems within an Integrated Modular Avionics (IMA) architecture. The purpose of the AECS Test Project is twofold. First, it provides a means to test the AECS hardware and system developed by MSG. Second, it provides an example project upon which future AECS research may be based. This Software Guide fully describes building, installing, and executing the AECS Test Project as well as its architecture and design. The design of the AECS hardware is described in the AECS Hardware Guide. Instructions on how to configure, build and use the AECS are described in the User's Guide. Sample AECS software, developed by the WVHTC Foundation, is presented in the AECS Software Guide. The AECS Hardware Guide, AECS User's Guide, and AECS Software Guide are authored by MSG. The requirements set forth for AECS are presented in the Statement of Work for the Assessment Environment for Complex Systems authored by NASA Dryden Flight Research Center (DFRC). The intended audience for this document includes software engineers, hardware engineers, project managers, and quality assurance personnel from WVHTC Foundation (the suppliers of the software), NASA (the customer), and future researchers (users of the software). Readers are assumed to have general knowledge in the field of real-time, embedded computer software development.

  13. SoC-based architecture for biomedical signal processing.

    Science.gov (United States)

    Gutiérrez-Rivas, R; Hernández, A; García, J J; Marnane, W

    2015-08-01

    Over the last decades, many algorithms have been proposed for processing biomedical signals. Most of these algorithms have been focused on the elimination of noise and artifacts existing in these signals, so they can be used for automatic monitoring and/or diagnosis applications. With regard to remote monitoring, the use of portable devices often requires a reduced number of resources and power consumption, being necessary to reach a trade-off between the accuracy of algorithms and their computational complexity. This paper presents a SoC (System-on-Chip) architecture, based on a FPGA (Field-Programmable Gate Array) device, suitable for the implementation of biomedical signal processing. The proposal has been successfully validated by implementing an efficient QRS complex detector. The results show that, using a reduced amount of resources, values of sensitivity and positive predictive value above 99.49% are achieved, which make the proposed approach suitable for telemedicine applications. PMID:26737663

  14. Advances in biomedical dosimetry

    International Nuclear Information System (INIS)

    Full text: Radiation dosimetry, the accurate determination of the absorbed dose within an irradiated body or a piece of material, is a prerequisite for all applications of ionizing radiation. This has been known since the very first radiation applications in medicine and biology, and increasing efforts are being made by radiation researchers to develop more reliable, effective and safe instruments, and to further improve dosimetric accuracy for all types of radiation used. Development of new techniques and instrumentation was particularly fast in the field of both medical diagnostic and therapeutic radiology. Thus, in Paris in October the IAEA held the latest symposium in its continuing series on dosimetry in medicine and biology. The last one was held in Vienna in 1975. High-quality dosimetry is obviously of great importance for human health, whether the objectives lie in the prevention and control of risks associated with the nuclear industry, in medical uses of radioactive substances or X-ray beams for diagnostic purposes, or in the application of photon, electron or neutron beams in radiotherapy. The symposium dealt with the following subjects: General aspects of dosimetry; Special physical and biomedical aspects; Determination of absorbed dose; Standardization and calibration of dosimetric systems; and Development of dosimetric systems. The forty or so papers presented and the discussions that followed them brought out a certain number of dominant themes, among which three deserve particular mention. - The recent generalization of the International System of Units having prompted a fundamental reassessment of the dosimetric quantities to be considered in calibrating measuring instruments, various proposals were advanced by the representatives of national metrology laboratories to replace the quantity 'exposure' (SI unit = coulomb/kg) by 'Kerma' or 'absorbed dose' (unit joule/kg, the special name of which is 'gray'), this latter being closer to the practical

  15. Theories and simulations of complex social systems

    CERN Document Server

    Mago, Vijay

    2014-01-01

    Research into social systems is challenging due to their complex nature. Traditional methods of analysis are often difficult to apply effectively as theories evolve over time. This can be due to a lack of appropriate data, or too much uncertainty. It can also be the result of problems which are not yet understood well enough in the general sense so that they can be classified, and an appropriate solution quickly identified. Simulation is one tool that deals well with these challenges, fits in well with the deductive process, and is useful for testing theory. This field is still relatively new, and much of the work is necessarily innovative, although it builds upon a rich and varied foundation. There are a number of existing modelling paradigms being applied to complex social systems research. Additionally, new methods and measures are being devised through the process of conducting research. We expect that readers will enjoy the collection of high quality research works from new and accomplished researchers. ...

  16. Intrinsic Uncertainties in Modeling Complex Systems.

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Curtis S; Bramson, Aaron L.; Ames, Arlo L.

    2014-09-01

    Models are built to understand and predict the behaviors of both natural and artificial systems. Because it is always necessary to abstract away aspects of any non-trivial system being modeled, we know models can potentially leave out important, even critical elements. This reality of the modeling enterprise forces us to consider the prospective impacts of those effects completely left out of a model - either intentionally or unconsidered. Insensitivity to new structure is an indication of diminishing returns. In this work, we represent a hypothetical unknown effect on a validated model as a finite perturba- tion whose amplitude is constrained within a control region. We find robustly that without further constraints, no meaningful bounds can be placed on the amplitude of a perturbation outside of the control region. Thus, forecasting into unsampled regions is a very risky proposition. We also present inherent difficulties with proper time discretization of models and representing in- herently discrete quantities. We point out potentially worrisome uncertainties, arising from math- ematical formulation alone, which modelers can inadvertently introduce into models of complex systems. Acknowledgements This work has been funded under early-career LDRD project %23170979, entitled %22Quantify- ing Confidence in Complex Systems Models Having Structural Uncertainties%22, which ran from 04/2013 to 09/2014. We wish to express our gratitude to the many researchers at Sandia who con- tributed ideas to this work, as well as feedback on the manuscript. In particular, we would like to mention George Barr, Alexander Outkin, Walt Beyeler, Eric Vugrin, and Laura Swiler for provid- ing invaluable advice and guidance through the course of the project. We would also like to thank Steven Kleban, Amanda Gonzales, Trevor Manzanares, and Sarah Burwell for their assistance in managing project tasks and resources.

  17. MEMS biomedical implants

    Institute of Scientific and Technical Information of China (English)

    Tai Yuchong

    2012-01-01

    The field of micro-electro-mechanical systems (MEMS) has advanced tremendously for the last 20 years. Most commercially noticeably, the field has successfully advanced from pressure sensors to micro physical sensors, such as accelerometers and gyros, for handheld electronics application. In parallel, MEMS has also advanced into micro total analysis system(TAS) and/or lab-on-a-chip applications. This article would discuss a relatively new but promising future direction towards MEMS biomedical implants. Specifically, Parylene C has been explored to be used as a good MEMS implant material and will be discussed in detail. Demonstrated implant devices, such as retinal and spinal cord implants, are presented in this article.

  18. Solving complex problems: Human identification and control of complex systems

    OpenAIRE

    Funke, Joachim

    1991-01-01

    Studying complex problem solving by means of computer-simulated scenarios has become one of the favorite themes of modern theorists in German-speaking countries who are concerned with the psychology of thinking. Following the pioneering work of Dietrich Doerner (University of Bamberg, FRG) in the mid-70s, many new scenarios have been developed and applied in correlational as well as in experimental studies (for a review see Funke, 1988). Instead of studying problem-solving behavior in restric...

  19. On Complexity of Social System and Modern Thinking

    Institute of Scientific and Technical Information of China (English)

    HongsenWei

    2004-01-01

    This paper puts forward the idea that social system is an open complex macrosystem and summarized its eight characteristics. The research object of social system is also an open complex macro-system, thus the complex theory and systems thinking should be applied to research rather than the simplicity theory.

  20. Teaching biomedical applications to secondary students.

    Science.gov (United States)

    Openshaw, S; Fleisher, A; Ljunggren, C

    1999-01-01

    Certain aspects of biomedical engineering applications lend themselves well to experimentation that can be done by high school students. This paper describes two experiments done during a six-week summer internship program in which two high school students used electrodes, circuit boards, and computers to mimic a sophisticated heart monitor and also to control a robotic car. Our experience suggests that simple illustrations of complex instrumentation can be effective in introducing adolescents to the biomedical engineering field. PMID:11143394

  1. Complex flows in granular and quantum systems

    Science.gov (United States)

    Herrera, Mark Richard

    In this thesis we investigate three problems involving complex flows in granular and quantum systems. (a) We first study the dynamics of granular particles in a split-bottom shear cell experiment. We utilize network theory to quantify the dynamics of the granular system at the mesoscopic scale. We find an apparent phase transition in the formation of a giant component of broken links as a function of applied shear. These results are compared to a numerical model where breakages are based on the amount of local stretching in the granular pile. (b) Moving to quantum mechanical systems, we study revival and echo phenomena in systems of anharmonically confined atoms, and find a novel phenomena we call the "pre-revival echo". We study the effect of size and symmetry of the perturbations on the various echoes and revivals, and form a perturbative model to describe the phenomena. We then model the effect of interactions using the Gross-Pitaevskii Equation and study interactions' effect on the revivals. (c) Lastly, we continue to study the effect of interactions on particles in weakly anharmonic traps. We numerically observe a "dynamical localization" phenomena in the presence of both anharmonicity and interactions. States may remain localized or become spread out in the potential depending on the strength and sign of the anharmonicity and interactions. We formulate a model for this phenomena in terms of a classical phase space.

  2. Statistically validated networks in bipartite complex systems

    CERN Document Server

    Tumminello, Michele; Lillo, Fabrizio; Piilo, Jyrki; Mantegna, Rosario N

    2010-01-01

    Many complex systems present an intrinsic bipartite nature and are often described and modeled in terms of networks [1-5]. Examples include movies and actors [1, 2, 4], authors and scientific papers [6-9], email accounts and emails [10], plants and animals that pollinate them [11, 12]. Bipartite networks are often very heterogeneous in the number of relationships that the elements of one set establish with the elements of the other set. When one constructs a projected network with nodes from only one set, the system heterogeneity makes it very difficult to identify preferential links between the elements. Here we introduce an unsupervised method to statistically validate each link of the projected network against a null hypothesis taking into account the heterogeneity of the system. We apply our method to three different systems, namely the set of clusters of orthologous genes (COG) in completely sequenced genomes [13, 14], a set of daily returns of 500 US financial stocks, and the set of world movies of the ...

  3. SINTHESES AND FUNCTIONALIZATION OF POLY(L-LACTIDE) BASED NANOCOMPOSITES SYSTEMS FOR SELECTIVE AND CONTROLLED DRUG RELEASE IN BIOMEDICAL USES

    OpenAIRE

    Casini, Gabriele

    2012-01-01

    In this thesis, the research activity, focused on two investigations topics, both addressed to the preparation and characterization of poly(L-lactide) (PLLA) based nano-materials for biomedical applications, is reported. In particular, the research deals with the preparation of a new polymeric substrate for vaccine (line 1) and superparamagnetic nanoparticles-PLLA core-shell nanocomposites for targeted and controlled release of anti-tumor drugs (line 2).The polymer we used in both the resea...

  4. Biomedical text mining and its applications in cancer research.

    Science.gov (United States)

    Zhu, Fei; Patumcharoenpol, Preecha; Zhang, Cheng; Yang, Yang; Chan, Jonathan; Meechai, Asawin; Vongsangnak, Wanwipa; Shen, Bairong

    2013-04-01

    Cancer is a malignant disease that has caused millions of human deaths. Its study has a long history of well over 100years. There have been an enormous number of publications on cancer research. This integrated but unstructured biomedical text is of great value for cancer diagnostics, treatment, and prevention. The immense body and rapid growth of biomedical text on cancer has led to the appearance of a large number of text mining techniques aimed at extracting novel knowledge from scientific text. Biomedical text mining on cancer research is computationally automatic and high-throughput in nature. However, it is error-prone due to the complexity of natural language processing. In this review, we introduce the basic concepts underlying text mining and examine some frequently used algorithms, tools, and data sets, as well as assessing how much these algorithms have been utilized. We then discuss the current state-of-the-art text mining applications in cancer research and we also provide some resources for cancer text mining. With the development of systems biology, researchers tend to understand complex biomedical systems from a systems biology viewpoint. Thus, the full utilization of text mining to facilitate cancer systems biology research is fast becoming a major concern. To address this issue, we describe the general workflow of text mining in cancer systems biology and each phase of the workflow. We hope that this review can (i) provide a useful overview of the current work of this field; (ii) help researchers to choose text mining tools and datasets; and (iii) highlight how to apply text mining to assist cancer systems biology research. PMID:23159498

  5. Introduction to biomedical engineering

    CERN Document Server

    Enderle, John

    2011-01-01

    Introduction to Biomedical Engineering is a comprehensive survey text for biomedical engineering courses. It is the most widely adopted text across the BME course spectrum, valued by instructors and students alike for its authority, clarity and encyclopedic coverage in a single volume. Biomedical engineers need to understand the wide range of topics that are covered in this text, including basic mathematical modeling; anatomy and physiology; electrical engineering, signal processing and instrumentation; biomechanics; biomaterials science and tissue engineering; and medical and engineering e

  6. Complex biological and bio-inspired systems

    Energy Technology Data Exchange (ETDEWEB)

    Ecke, Robert E [Los Alamos National Laboratory

    2009-01-01

    The understanding and characterization ofthe fundamental processes of the function of biological systems underpins many of the important challenges facing American society, from the pathology of infectious disease and the efficacy ofvaccines, to the development of materials that mimic biological functionality and deliver exceptional and novel structural and dynamic properties. These problems are fundamentally complex, involving many interacting components and poorly understood bio-chemical kinetics. We use the basic science of statistical physics, kinetic theory, cellular bio-chemistry, soft-matter physics, and information science to develop cell level models and explore the use ofbiomimetic materials. This project seeks to determine how cell level processes, such as response to mechanical stresses, chemical constituents and related gradients, and other cell signaling mechanisms, integrate and combine to create a functioning organism. The research focuses on the basic physical processes that take place at different levels ofthe biological organism: the basic role of molecular and chemical interactions are investigated, the dynamics of the DNA-molecule and its phylogenetic role are examined and the regulatory networks of complex biochemical processes are modeled. These efforts may lead to early warning algorithms ofpathogen outbreaks, new bio-sensors to detect hazards from pathomic viruses to chemical contaminants. Other potential applications include the development of efficient bio-fuel alternative-energy processes and the exploration ofnovel materials for energy usages. Finally, we use the notion of 'coarse-graining,' which is a method for averaging over less important degrees of freedom to develop computational models to predict cell function and systems-level response to disease, chemical stress, or biological pathomic agents. This project supports Energy Security, Threat Reduction, and the missions of the DOE Office of Science through its efforts to

  7. Fundamental of biomedical engineering

    CERN Document Server

    Sawhney, GS

    2007-01-01

    About the Book: A well set out textbook explains the fundamentals of biomedical engineering in the areas of biomechanics, biofluid flow, biomaterials, bioinstrumentation and use of computing in biomedical engineering. All these subjects form a basic part of an engineer''s education. The text is admirably suited to meet the needs of the students of mechanical engineering, opting for the elective of Biomedical Engineering. Coverage of bioinstrumentation, biomaterials and computing for biomedical engineers can meet the needs of the students of Electronic & Communication, Electronic & Instrumenta

  8. Applications of computational intelligence in biomedical technology

    CERN Document Server

    Majernik, Jaroslav; Pancerz, Krzysztof; Zaitseva, Elena

    2016-01-01

    This book presents latest results and selected applications of Computational Intelligence in Biomedical Technologies. Most of contributions deal with problems of Biomedical and Medical Informatics, ranging from theoretical considerations to practical applications. Various aspects of development methods and algorithms in Biomedical and Medical Informatics as well as Algorithms for medical image processing, modeling methods are discussed. Individual contributions also cover medical decision making support, estimation of risks of treatments, reliability of medical systems, problems of practical clinical applications and many other topics  This book is intended for scientists interested in problems of Biomedical Technologies, for researchers and academic staff, for all dealing with Biomedical and Medical Informatics, as well as PhD students. Useful information is offered also to IT companies, developers of equipment and/or software for medicine and medical professionals.  .

  9. Optimal sensor configuration for complex systems

    DEFF Research Database (Denmark)

    Sadegh, Payman; Spall, J. C.

    1998-01-01

    Considers the problem of sensor configuration for complex systems. Our approach involves definition of an appropriate optimality criterion or performance measure, and description of an efficient and practical algorithm for achieving the optimality objective. The criterion for optimal sensor...... configuration is based on maximizing the overall sensor response while minimizing the correlation among the sensor outputs. The procedure for sensor configuration is based on simultaneous perturbation stochastic approximation (SPSA). SPSA avoids the need for detailed modeling of the sensor response by simply...... relying on observed responses as obtained by limited experimentation with test sensor configurations. We illustrate the approach with the optimal placement of acoustic sensors for signal detection in structures. This includes both a computer simulation study for an aluminum plate, and real...

  10. Exergy Analysis of Complex Ship Energy Systems

    Directory of Open Access Journals (Sweden)

    Pierre Marty

    2016-04-01

    Full Text Available With multiple primary and secondary energy converters (diesel engines, steam turbines, waste heat recovery (WHR and oil-fired boilers, etc. and extensive energy networks (steam, cooling water, exhaust gases, etc., ships may be considered as complex energy systems. Understanding and optimizing such systems requires advanced holistic energy modeling. This modeling can be done in two ways: The simpler approach focuses on energy flows, and has already been tested, approved and presented; a new, more complicated approach, focusing on energy quality, i.e., exergy, is presented in this paper. Exergy analysis has rarely been applied to ships, and, as a general rule, the shipping industry is not familiar with this tool. This paper tries to fill this gap. We start by giving a short reminder of what exergy is and describe the principles of exergy modeling to explain what kind of results should be expected from such an analysis. We then apply these principles to the analysis of a large two-stroke diesel engine with its cooling and exhaust systems. Simulation results are then presented along with the exergy analysis. Finally, we propose solutions for energy and exergy saving which could be applied to marine engines and ships in general.

  11. Natural immunoglobulins (contribution to a debate on biomedical education

    Directory of Open Access Journals (Sweden)

    Vaz Nelson M

    2000-01-01

    Full Text Available Immunology has contributed to biomedical education in many important ways since the creation of scientific medicine in the last quarter of the 19th century. Today, immunology is a major area of biomedical research. Nevertheless, there are many basic problems unresolved in immunological activities and phenomena. Solving these problems is probably necessary to devise predictable and safe ways to produce new vaccines, treat allergy and autoimmune diseases and perform safe transplants. This challenge involves not only technical developments but also changes in attitude, of which the most fundamental is to abandon the traditional stimulus-response perspective in favor of more "systemic" views. Describing immunological activities as the operation of a complex multiconnected network, raises biological and epistemological issues not usually dealt with in biomedical education. Here we point to one example of systemic approaches. A new form of immunoblot (Panama blot, by which the reaction of natural immunoglobulins with complex protein mixtures may be analyzed by a special software and multivariate statistics, has been recently used to characterize human autoimmune diseases. Our preliminary data show that Panama blots can also be used to characterize global (systemic immunogical changes in chronic human parasitic diseases, such as malaria and schistosomiasis mansoni, that correlate with the clinical status.

  12. Self-organization and collective behaviour in complex systems

    OpenAIRE

    Editors

    2014-01-01

    It is our great honour to present the CMP special issue devoted to self-organization and collective behaviour in complex systems. A complex system is a system whose emergent properties are not simple sums of the properties of its components. Since complex systems involve cooperative behaviour of many interconnected components, the field of statistical physics provides a perfect conceptual and mathematical framework for their quantitative understanding. Critical phenomena and complexity have c...

  13. Methods and Techniques of Complex Systems Science: An Overview

    OpenAIRE

    Shalizi, Cosma Rohilla

    2003-01-01

    In this chapter, I review the main methods and techniques of complex systems science. As a first step, I distinguish among the broad patterns which recur across complex systems, the topics complex systems science commonly studies, the tools employed, and the foundational science of complex systems. The focus of this chapter is overwhelmingly on the third heading, that of tools. These in turn divide, roughly, into tools for analyzing data, tools for constructing and evaluating models, and tool...

  14. UMLS knowledge for biomedical language processing.

    OpenAIRE

    McCray, A T; Aronson, A. R.; Browne, A. C.; Rindflesch, T. C.; A razi; Srinivasan, S

    1993-01-01

    This paper describes efforts to provide access to the free text in biomedical databases. The focus of the effort is the development of SPECIALIST, an experimental natural language processing system for the biomedical domain. The system includes a broad coverage parser supported by a large lexicon, modules that provide access to the extensive Unified Medical Language System (UMLS) Knowledge Sources, and a retrieval module that permits experiments in information retrieval. The UMLS Metathesauru...

  15. Adaptive generalized combination complex synchronization of uncertain real and complex nonlinear systems

    Science.gov (United States)

    Wang, Shi-bing; Wang, Xing-yuan; Wang, Xiu-you; Zhou, Yu-fei

    2016-04-01

    With comprehensive consideration of generalized synchronization, combination synchronization and adaptive control, this paper investigates a novel adaptive generalized combination complex synchronization (AGCCS) scheme for different real and complex nonlinear systems with unknown parameters. On the basis of Lyapunov stability theory and adaptive control, an AGCCS controller and parameter update laws are derived to achieve synchronization and parameter identification of two real drive systems and a complex response system, as well as two complex drive systems and a real response system. Two simulation examples, namely, ACGCS for chaotic real Lorenz and Chen systems driving a hyperchaotic complexsystem, and hyperchaotic complex Lorenz and Chen systems driving a real chaotic Lü system, are presented to verify the feasibility and effectiveness of the proposed scheme.

  16. Understanding Complex Adaptive Systems by Playing Games

    Science.gov (United States)

    van Bilsen, Arthur; Bekebrede, Geertje; Mayer, Igor

    2010-01-01

    While educators teach their students about decision making in complex environments, managers have to deal with the complexity of large projects on a daily basis. To make better decisions it is assumed, that the latter would benefit from better understanding of complex phenomena, as do students as the professionals of the future. The goal of this…

  17. Biomedical Visual Computing: Case Studies and Challenges

    KAUST Repository

    Johnson, Christopher

    2012-01-01

    Advances in computational geometric modeling, imaging, and simulation let researchers build and test models of increasing complexity, generating unprecedented amounts of data. As recent research in biomedical applications illustrates, visualization will be critical in making this vast amount of data usable; it\\'s also fundamental to understanding models of complex phenomena. © 2012 IEEE.

  18. Major depression as a complex dynamical system

    CERN Document Server

    Cramer, Angélique O J; Giltay, Erik J; van der Maas, Han L J; Kendler, Kenneth S; Scheffer, Marten; Borsboom, Denny

    2016-01-01

    In this paper, we characterize major depression (MD) as a complex dynamical system in which symptoms (e.g., insomnia and fatigue) are directly connected to one another in a network structure. We hypothesize that individuals can be characterized by their own network with unique architecture and resulting dynamics. With respect to architecture, we show that individuals vulnerable to developing MD are those with strong connections between symptoms: e.g., only one night of poor sleep suffices to make a particular person feel tired. Such vulnerable networks, when pushed by forces external to the system such as stress, are more likely to end up in a depressed state; whereas networks with weaker connections tend to remain in or return to a healthy state. We show this with a simulation in which we model the probability of a symptom becoming active as a logistic function of the activity of its neighboring symptoms. Additionally, we show that this model potentially explains some well-known empirical phenomena such as s...

  19. A complex systems approach to bibliometrics

    Science.gov (United States)

    Stringer, Michael J.

    Enabled by technological change, we are in the midst of a fundamental shift in how scientific information is produced and communicated. Electronic publishing, preprint archives, blogs, and wikis are emerging as possible viable alternatives to the current journal publishing and peer review system. However, these new technologies flood the environment with information, making it increasingly difficult to find the highest quality and most relevant papers. Additionally, accreditation and quality assessment of published material becomes nearly impossible for agencies interested in funding the research and development that is most likely to succeed. Recently, bibliometric tools have emerged as an effective means for the filtering, accreditation, and assessment of scholarly information. In this thesis, we approach bibliometrics from a complex systems perspective. A unique characteristic of the work presented in this thesis is that we perform empirical validation of bibliometric models using the most comprehensive bibliographic database available. Using these methods, we quantify the dynamics of citations to scientific journals, and investigate the relationship between social network position and research performance.

  20. Design in Complex Systems: Individual Performance versus System Efficiency

    CERN Document Server

    Gou, C

    2005-01-01

    This paper studies the correlations of the average winnings of agents and the volatilities of systems based on mix-game model which is an extension of minority game (MG). In mix-game, there are two groups of agents; group1 plays the majority game, but the group2 plays the minority game. The results show that the correlations between the average winnings of agents and the mean of local volatilities are different with different combinations of agents' memory lengths when the proportion of agents in group1 increases. The average winnings of agents can represent the average individual performance and the volatility of a system can represent the efficiency of the system. Therefore, these results imply that the combinations of agents' memory lengths largely influence the relation between the system efficiency and the average individual performance. These results could give some guidance in designing complex systems.

  1. Economic decision making: application of the theory of complex systems

    OpenAIRE

    Robert Kitt

    2012-01-01

    In this chapter the complex systems are discussed in the context of economic and business policy and decision making. It will be showed and motivated that social systems are typically chaotic, non-linear and/or non-equilibrium and therefore complex systems. It is discussed that the rapid change in global consumer behaviour is underway, that further increases the complexity in business and management. For policy making under complexity, following principles are offered: openness and internatio...

  2. Metabolic Scaling in Complex Living Systems

    Directory of Open Access Journals (Sweden)

    Douglas S. Glazier

    2014-10-01

    Full Text Available In this review I show that four major kinds of theoretical approaches have been used to explain the scaling of metabolic rate in cells, organisms and groups of organisms in relation to system size. They include models focusing on surface-area related fluxes of resources and wastes (including heat, internal resource transport, system composition, and various processes affecting resource demand, all of which have been discussed extensively for nearly a century or more. I argue that, although each of these theoretical approaches has been applied to multiple levels of biological organization, none of them alone can fully explain the rich diversity of metabolic scaling relationships, including scaling exponents (log-log slopes that vary from ~0 to >1. Furthermore, I demonstrate how a synthetic theory of metabolic scaling can be constructed by including the context-dependent action of each of the above modal effects. This “contextual multimodal theory” (CMT posits that various modulating factors (including metabolic level, surface permeability, body shape, modes of thermoregulation and resource-transport, and other internal and external influences affect the mechanistic expression of each theoretical module. By involving the contingent operation of several mechanisms, the “meta-mechanistic” CMT differs from most metabolic scaling theories that are deterministically mechanistic. The CMT embraces a systems view of life, and as such recognizes the open, dynamic nature and complex hierarchical and interactive organization of biological systems, and the importance of multiple (upward, downward and reciprocal causation, biological regulation of resource supply and demand and their interaction, and contingent internal (system and external (environmental influences on metabolic scaling, all of which are discussed. I hope that my heuristic attempt at building a unifying theory of metabolic scaling will not only stimulate further testing of all of the

  3. Research on basic characteristics of complex system brittleness

    Institute of Scientific and Technical Information of China (English)

    JIN Hong-zhang; GUO Jian; WEI Qi; LIN De-ming; LI Qi

    2004-01-01

    Tbe goal of this paper is to research one new characteristic of complex system. Brittleness, which is one new characteritic of complex system, is presented in this paper. The linguistic and qualitative descriptions of complex system are also given in this paper.Otherwise, the qualitative description of complex system is presented at first. On the basis of analyzing the existing brittleness problems, linguistic description and mathematic description of brittleness are given as well. Three kinds of phenomena to judge brittleness of complex system are also given, based on catastrophe theory. Basic characteristics of brittleness are given on the basis of its mathematic description. Two critical point sets are defined by using catastrophe theory. The definition of brittleness and its related theory can serve the control of complex system, and provide theoretical basis for the design and control of complex system.

  4. Advanced computational approaches to biomedical engineering

    CERN Document Server

    Saha, Punam K; Basu, Subhadip

    2014-01-01

    There has been rapid growth in biomedical engineering in recent decades, given advancements in medical imaging and physiological modelling and sensing systems, coupled with immense growth in computational and network technology, analytic approaches, visualization and virtual-reality, man-machine interaction and automation. Biomedical engineering involves applying engineering principles to the medical and biological sciences and it comprises several topics including biomedicine, medical imaging, physiological modelling and sensing, instrumentation, real-time systems, automation and control, sig

  5. Nanomaterials driven energy, environmental and biomedical research

    International Nuclear Information System (INIS)

    We have developed state-of-the-art nanomaterials such as nanofibers, nanotubes, nanoparticles, nanocatalysts and nanostructures for clean energy, environmental and biomedical research. Energy can neither be created nor be destroyed, but it can be converted from one form to another. Based on this principle, chemical energy such as hydrogen has been produced from water electrolysis at a much lower voltage using RuO2 nanoparticles on the Si wafer substrate. Once the hydrogen is produced from the clean sources such as solar energy and water, it has to be stored by physisorption or chemisorption processes on to the solid state systems. For the successful physical adsorption of hydrogen molecule, we have developed novel polyaniline nanostructures via chemical templating and electrospinning routes. Chemical or complex hydrides involving nano MgH2 and transition metal nanocatalysts have been synthesized to tailor both the thermodynamics and kinetics of hydrogen (chemi) sorption respectively. Utilization of solar energy (UV-Vis) and a coupling of novel semiconductor oxide nanoparticles have been recently demonstrated with enhancement in photo-oxidation and/or photo-reduction processes for the water/air detoxification and sustainable liquid fuel production respectively. Magnetic nanoparticles such as ZnFe2O4 have been synthesized and optimized for biomedical applications such as targeted drug delivery and tumor diagnostic sensing (MRI)

  6. Nanomaterials driven energy, environmental and biomedical research

    Science.gov (United States)

    Sharma, Prakash C.; Srinivasan, Sesha S.; Wilson, Jeremiah F.

    2014-03-01

    We have developed state-of-the-art nanomaterials such as nanofibers, nanotubes, nanoparticles, nanocatalysts and nanostructures for clean energy, environmental and biomedical research. Energy can neither be created nor be destroyed, but it can be converted from one form to another. Based on this principle, chemical energy such as hydrogen has been produced from water electrolysis at a much lower voltage using RuO2 nanoparticles on the Si wafer substrate. Once the hydrogen is produced from the clean sources such as solar energy and water, it has to be stored by physisorption or chemisorption processes on to the solid state systems. For the successful physical adsorption of hydrogen molecule, we have developed novel polyaniline nanostructures via chemical templating and electrospinning routes. Chemical or complex hydrides involving nano MgH2 and transition metal nanocatalysts have been synthesized to tailor both the thermodynamics and kinetics of hydrogen (chemi) sorption respectively. Utilization of solar energy (UV-Vis) and a coupling of novel semiconductor oxide nanoparticles have been recently demonstrated with enhancement in photo-oxidation and/or photo-reduction processes for the water/air detoxification and sustainable liquid fuel production respectively. Magnetic nanoparticles such as ZnFe2O4 have been synthesized and optimized for biomedical applications such as targeted drug delivery and tumor diagnostic sensing (MRI).

  7. A Remote Health Care System Combining a Fall Down Alarm and Biomedical Signal Monitor System in an Android Smart-Phone

    Directory of Open Access Journals (Sweden)

    Ching-Sung Wang

    2013-10-01

    Full Text Available First aid and immediate help are very important following an accident. The earlier the detection and treatment is carried out, the better the prognosis and chance of recovery of the patients. It is even more important when considering the elderly. Once the elderly have an accident, they not only physically injure their body, but also impair their mental and social ability, and may develop severe sequela. In the last few years, the continuously developed Android cell phone has been applied to many fields. Despite the nature of the GPS positioning system that the mobile phone currently uses, most applications used are SMS and file transfers. However, these biomedical measurement signals, passing through a transferring interface and uploading to the mobile, result the little really successful cases with the remote health care feasibility. This research will develop an Android cell phone which combines the functionality of an ECG, pulsimeter, SpO2, and BAD (Body Activity Detector for real-time monitoring of the activity of a body. When an accident occurs, the signals go through Android smart phone, immediately notifying the remote ends and providing first time help.

  8. Management Strategies for Complex Adaptive Systems: Sensemaking, Learning, and Improvisation

    Science.gov (United States)

    McDaniel, Reuben R., Jr.

    2007-01-01

    Misspecification of the nature of organizations may be a major reason for difficulty in achieving performance improvement. Organizations are often viewed as machine-like, but complexity science suggests that organizations should be viewed as complex adaptive systems. I identify the characteristics of complex adaptive systems and give examples of…

  9. Advances in Electronic-Nose Technologies Developed for Biomedical Applications

    OpenAIRE

    Wilson, Alphus D.; Manuela Baietto

    2011-01-01

    The research and development of new electronic-nose applications in the biomedical field has accelerated at a phenomenal rate over the past 25 years. Many innovative e-nose technologies have provided solutions and applications to a wide variety of complex biomedical and healthcare problems. The purposes of this review are to present a comprehensive analysis of past and recent biomedical research findings and developments of electronic-nose sensor technologies, and to identify current and futu...

  10. Shape-Memory Polymers for Biomedical Applications

    Science.gov (United States)

    Yakacki, Christopher M.; Gall, Ken

    Shape-memory polymers (SMPs) are a class of mechanically functional "smart" materials that have generated substantial interest for biomedical applications. SMPs offer the ability to promote minimally invasive surgery, provide structural support, exert stabilizing forces, elute therapeutic agents, and biodegrade. This review focuses on several areas of biomedicine including vascular, orthopedic, and neuronal applications with respect to the progress and potential for SMPs to improve the standard of treatment in these areas. Fundamental studies on proposed biomedical SMP systems are discussed with regards to biodegradability, tailorability, sterilization, and biocompatibility. Lastly, a proposed research and development pathway for SMP-based biomedical devices is proposed based on trends in the recent literature.

  11. Translational Bioinformatics and Clinical Research (Biomedical) Informatics.

    Science.gov (United States)

    Sirintrapun, S Joseph; Zehir, Ahmet; Syed, Aijazuddin; Gao, JianJiong; Schultz, Nikolaus; Cheng, Donavan T

    2016-03-01

    Translational bioinformatics and clinical research (biomedical) informatics are the primary domains related to informatics activities that support translational research. Translational bioinformatics focuses on computational techniques in genetics, molecular biology, and systems biology. Clinical research (biomedical) informatics involves the use of informatics in discovery and management of new knowledge relating to health and disease. This article details 3 projects that are hybrid applications of translational bioinformatics and clinical research (biomedical) informatics: The Cancer Genome Atlas, the cBioPortal for Cancer Genomics, and the Memorial Sloan Kettering Cancer Center clinical variants and results database, all designed to facilitate insights into cancer biology and clinical/therapeutic correlations. PMID:26851671

  12. Complexity Analysis and Critical Factor Identity in Multimedia Social Systems

    OpenAIRE

    Dali Li

    2014-01-01

    The rapid development of multimedia social systems makes the exchange and the share of the information between users more and more convenient. At the same time, it also makes that the multimedia social systems have complexity characteristic. Hence the traditional object-oriented analysis methods have been not able to suit this kind of saturation. This paper analyzes the complexity of social multimedia systems and proposes that the complexity performance of multimedia social systems includes t...

  13. The engineering of concurrent simulations of complex systems

    OpenAIRE

    Polack, Fiona A.C.; Andrews, Paul S.; Sampson, Adam T

    2009-01-01

    Concurrent process-oriented programming is a natural medium for simulating complex systems, particularly systems where many simple components interact in an environment (which may itself be complex). There is little guidance for engineering complex systems simulation. In the context of simulation work to support immunological research, we explore relevant approaches to modelling, and draw on concepts from dependable and high-integrity systems engineering, including the emphasis on the need to...

  14. Introduction to biomedical engineering technology

    CERN Document Server

    Street, Laurence J

    2011-01-01

    IntroductionHistory of Medical DevicesThe Role of Biomedical Engineering Technologists in Health CareCharacteristics of Human Anatomy and Physiology That Relate to Medical DevicesSummaryQuestionsDiagnostic Devices: Part OnePhysiological Monitoring SystemsThe HeartSummaryQuestionsDiagnostic Devices: Part TwoCirculatory System and BloodRespiratory SystemNervous SystemSummaryQuestionsDiagnostic Devices: Part ThreeDigestive SystemSensory OrgansReproductionSkin, Bone, Muscle, MiscellaneousChapter SummaryQuestionsDiagnostic ImagingIntroductionX-RaysMagnetic Resonance Imaging ScannersPositron Emissio

  15. Handbook of biomedical optics

    CERN Document Server

    Boas, David A

    2011-01-01

    Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.Organized into six sections, this handbook: Contains intr

  16. Biomedical applications of polymers

    CERN Document Server

    Gebelein, C G

    1991-01-01

    The biomedical applications of polymers span an extremely wide spectrum of uses, including artificial organs, skin and soft tissue replacements, orthopaedic applications, dental applications, and controlled release of medications. No single, short review can possibly cover all these items in detail, and dozens of books andhundreds of reviews exist on biomedical polymers. Only a few relatively recent examples will be cited here;additional reviews are listed under most of the major topics in this book. We will consider each of the majorclassifications of biomedical polymers to some extent, inclu

  17. Powering biomedical devices

    CERN Document Server

    Romero, Edwar

    2013-01-01

    From exoskeletons to neural implants, biomedical devices are no less than life-changing. Compact and constant power sources are necessary to keep these devices running efficiently. Edwar Romero's Powering Biomedical Devices reviews the background, current technologies, and possible future developments of these power sources, examining not only the types of biomedical power sources available (macro, mini, MEMS, and nano), but also what they power (such as prostheses, insulin pumps, and muscular and neural stimulators), and how they work (covering batteries, biofluids, kinetic and ther

  18. Biomedical Engineering Desk Reference

    CERN Document Server

    Ratner, Buddy D; Schoen, Frederick J; Lemons, Jack E; Dyro, Joseph; Martinsen, Orjan G; Kyle, Richard; Preim, Bernhard; Bartz, Dirk; Grimnes, Sverre; Vallero, Daniel; Semmlow, John; Murray, W Bosseau; Perez, Reinaldo; Bankman, Isaac; Dunn, Stanley; Ikada, Yoshito; Moghe, Prabhas V; Constantinides, Alkis

    2009-01-01

    A one-stop Desk Reference, for Biomedical Engineers involved in the ever expanding and very fast moving area; this is a book that will not gather dust on the shelf. It brings together the essential professional reference content from leading international contributors in the biomedical engineering field. Material covers a broad range of topics including: Biomechanics and Biomaterials; Tissue Engineering; and Biosignal Processing* A hard-working desk reference providing all the essential material needed by biomedical and clinical engineers on a day-to-day basis * Fundamentals, key techniques,

  19. Biomedical engineering fundamentals

    CERN Document Server

    Bronzino, Joseph D; Bronzino, Joseph D

    2006-01-01

    Over the last century,medicine has come out of the "black bag" and emerged as one of the most dynamic and advanced fields of development in science and technology. Today, biomedical engineering plays a critical role in patient diagnosis, care, and rehabilitation. As such, the field encompasses a wide range of disciplines, from biology and physiology to informatics and signal processing. Reflecting the enormous growth and change in biomedical engineering during the infancy of the 21st century, The Biomedical Engineering Handbook enters its third edition as a set of three carefully focused and

  20. The brittleness model of complex system based on cellular automata

    Institute of Scientific and Technical Information of China (English)

    LIN De-ming; JIN Hong-zhang; LI Qi; WU Hong-mei

    2004-01-01

    Now the research on the complex system is a hot spot. Brittleness is one of the basic characteristics of a complex system. In a complex system, after one of subsystems is struck to be collapsed, the whole system will collapse. Meanwhile, cellular automata is a discrete dynamic system. When the rule is given, the cellular automata could be defined. Then it can imitate the complex action. Cellular automata is used to simulate the brittleness action in this study. Entropy was used to analyze the action and get the rule. Then,three normal brittleness models were given. The result shows that the brittleness of complex system is existent and in addition some important behavior mode of complex system brittleness has been achieved.

  1. The BIRN Project: Distributed Information Infrastructure and Multi-scale Imaging of the Nervous System (BIRN = Biomedical Informatics Research Network)

    CERN Document Server

    CERN. Geneva

    2004-01-01

    The grand goal in neuroscience research is to understand how the interplay of structural, chemical and electrical signals in nervous tissue gives rise to behavior. Experimental advances of the past decades have given the individual neuroscientist an increasingly powerful arsenal for obtaining data, from the level of molecules to nervous systems. Scientists have begun the arduous and challenging process of adapting and assembling neuroscience data at all scales of resolution and across disciplines into computerized databases and other easily accessed sources. These databases will complement the vast structural and sequence databases created to catalogue, organize and analyze gene sequences and protein products. The general premise of the neuroscience goal is simple; namely that with "complete" knowledge of the genome and protein structures accruing rapidly we next need to assemble an infrastructure that will facilitate acquisition of an understanding for how functional complexes operate in their ...

  2. Applications of Nonlinear Dynamics Model and Design of Complex Systems

    CERN Document Server

    In, Visarath; Palacios, Antonio

    2009-01-01

    This edited book is aimed at interdisciplinary, device-oriented, applications of nonlinear science theory and methods in complex systems. In particular, applications directed to nonlinear phenomena with space and time characteristics. Examples include: complex networks of magnetic sensor systems, coupled nano-mechanical oscillators, nano-detectors, microscale devices, stochastic resonance in multi-dimensional chaotic systems, biosensors, and stochastic signal quantization. "applications of nonlinear dynamics: model and design of complex systems" brings together the work of scientists and engineers that are applying ideas and methods from nonlinear dynamics to design and fabricate complex systems.

  3. Multistage Spectral Relaxation Method for Solving the Hyperchaotic Complex Systems

    Directory of Open Access Journals (Sweden)

    Hassan Saberi Nik

    2014-01-01

    Full Text Available We present a pseudospectral method application for solving the hyperchaotic complex systems. The proposed method, called the multistage spectral relaxation method (MSRM is based on a technique of extending Gauss-Seidel type relaxation ideas to systems of nonlinear differential equations and using the Chebyshev pseudospectral methods to solve the resulting system on a sequence of multiple intervals. In this new application, the MSRM is used to solve famous hyperchaotic complex systems such as hyperchaotic complex Lorenz system and the complex permanent magnet synchronous motor. We compare this approach to the Runge-Kutta based ode45 solver to show that the MSRM gives accurate results.

  4. Environmental and biomedical applications of natural metal stable isotope variations

    Science.gov (United States)

    Bullen, T.D.; Walczyk, T.

    2009-01-01

    etal stable isotopes are now being used to trace metal contaminants in the environment and as indicators of human systemic function where metals play a role. Stable isotope abundance variations provide information about metal sources and the processes affecting metals in complex natural systems, complementing information gained from surrogate tracers, such as metal abundance ratios or biochemical markers of metal metabolism. The science is still in its infancy, but the results of initial studies confirm that metal stable isotopes can provide a powerful tool for forensic and biomedical investigations.

  5. Complexity theory, systems thinking and international relations

    OpenAIRE

    Bousquet, Antoine; Curtis, S

    2011-01-01

    The concepts, language and methods of complexity theory have been slowly making their way into international relations (IR), as scholars explore their potential for extending our understanding of the dynamics of international politics. In this article we examine the progress made so far and map the existing debates within IR that are liable to being significantly reconfigured by the conceptual resources of complexity. We consider the various ontological, epistemological and methodological que...

  6. Tethering Complexes in the Arabidopsis Endomembrane System.

    Science.gov (United States)

    Vukašinović, Nemanja; Žárský, Viktor

    2016-01-01

    Targeting of endomembrane transport containers is of the utmost importance for proper land plant growth and development. Given the immobility of plant cells, localized membrane vesicle secretion and recycling are amongst the main processes guiding proper cell, tissue and whole plant morphogenesis. Cell wall biogenesis and modification are dependent on vectorial membrane traffic, not only during normal development, but also in stress responses and in plant defense against pathogens and/or symbiosis. It is surprising how little we know about these processes in plants, from small GTPase regulation to the tethering complexes that act as their effectors. Tethering factors are single proteins or protein complexes mediating first contact between the target membrane and arriving membrane vesicles. In this review we focus on the tethering complexes of the best-studied plant model-Arabidopsis thaliana. Genome-based predictions indicate the presence of all major tethering complexes in plants that are known from a hypothetical last eukaryotic common ancestor (LECA). The evolutionary multiplication of paralogs of plant tethering complex subunits has produced the massively expanded EXO70 family, indicating a subfunctionalization of the terminal exocytosis machinery in land plants. Interpretation of loss of function (LOF) mutant phenotypes has to consider that related, yet clearly functionally-specific complexes often share some common core subunits. It is therefore impossible to conclude with clarity which version of the complex is responsible for the phenotypic deviations observed. Experimental interest in the analysis of plant tethering complexes is growing and we hope to contribute with this review by attracting even more attention to this fascinating field of plant cell biology. PMID:27243010

  7. Sensors for biomedical applications

    NARCIS (Netherlands)

    Bergveld, Piet

    1986-01-01

    This paper considers the impact during the last decade of modern IC technology, microelectronics, thin- and thick-film technology, fibre optic technology, etc. on the development of sensors for biomedical applications.

  8. Smart modeling and simulation for complex systems practice and theory

    CERN Document Server

    Ren, Fenghui; Zhang, Minjie; Ito, Takayuki; Tang, Xijin

    2015-01-01

    This book aims to provide a description of these new Artificial Intelligence technologies and approaches to the modeling and simulation of complex systems, as well as an overview of the latest scientific efforts in this field such as the platforms and/or the software tools for smart modeling and simulating complex systems. These tasks are difficult to accomplish using traditional computational approaches due to the complex relationships of components and distributed features of resources, as well as the dynamic work environments. In order to effectively model the complex systems, intelligent technologies such as multi-agent systems and smart grids are employed to model and simulate the complex systems in the areas of ecosystem, social and economic organization, web-based grid service, transportation systems, power systems and evacuation systems.

  9. Sharing big biomedical data

    OpenAIRE

    Toga, Arthur W.; Dinov, Ivo D.

    2015-01-01

    Background The promise of Big Biomedical Data may be offset by the enormous challenges in handling, analyzing, and sharing it. In this paper, we provide a framework for developing practical and reasonable data sharing policies that incorporate the sociological, financial, technical and scientific requirements of a sustainable Big Data dependent scientific community. Findings Many biomedical and healthcare studies may be significantly impacted by using large, heterogeneous and incongruent data...

  10. Biomedical signal processing

    CERN Document Server

    Akay, Metin

    1994-01-01

    Sophisticated techniques for signal processing are now available to the biomedical specialist! Written in an easy-to-read, straightforward style, Biomedical Signal Processing presents techniques to eliminate background noise, enhance signal detection, and analyze computer data, making results easy to comprehend and apply. In addition to examining techniques for electrical signal analysis, filtering, and transforms, the author supplies an extensive appendix with several computer programs that demonstrate techniques presented in the text.

  11. Biomedical signal analysis

    CERN Document Server

    Rangayyan, Rangaraj M

    2015-01-01

    The book will help assist a reader in the development of techniques for analysis of biomedical signals and computer aided diagnoses with a pedagogical examination of basic and advanced topics accompanied by over 350 figures and illustrations. Wide range of filtering techniques presented to address various applications. 800 mathematical expressions and equations. Practical questions, problems and laboratory exercises. Includes fractals and chaos theory with biomedical applications.

  12. What is biomedical informatics?

    OpenAIRE

    Bernstam, Elmer V.; Smith, Jack W.; Johnson, Todd R

    2009-01-01

    Biomedical informatics lacks a clear and theoretically grounded definition. Many proposed definitions focus on data, information, and knowledge, but do not provide an adequate definition of these terms. Leveraging insights from the philosophy of information, we define informatics as the science of information, where information is data plus meaning. Biomedical informatics is the science of information as applied to or studied in the context of biomedicine. Defining the object of study of info...

  13. Tax system complexity and compliance costs — some theoretical considerations

    OpenAIRE

    Tracy Oliver; Scott Bartley

    2005-01-01

    This paper examines some of the factors that influence the level of tax system complexity and taxpayers' compliance costs. The policy trade-offs and legislative and administrative design choices that are made during the development and implementation of a new provision have a direct bearing on the complexity of the tax system and the compliance costs of taxpayers. Private interest in minimising tax liabilities can also be an important driver of tax system complexity. This paper shows how tax-...

  14. Complexity: Outline of the NWO strategic theme Dynamics of complex systems

    OpenAIRE

    Burgers, G.; Doelman, A.; Frenken, K.; Hogeweg, P.; Hommes, C.; Maas, van der, H.L.J.; Mulder, B.; Stam, K.; Steen, van der, M.; Zandee, L.

    2008-01-01

    Dynamics of complex systems is one of the program 5 themes in the NWO (Netherlands Organisation for Scientific Research) strategy for the years 2007-2011. The ambition of the current proposal is to initiate integrated activities in the field of complex systems within the Netherlands, to provide opportunities for the Dutch scientific community to start up a research program on 'Complexity', and to join in, and give direction to, European activities in this field. At many levels of activity, Du...

  15. Complexity Thinking in PE: Game-Centred Approaches, Games as Complex Adaptive Systems, and Ecological Values

    Science.gov (United States)

    Storey, Brian; Butler, Joy

    2013-01-01

    Background: This article draws on the literature relating to game-centred approaches (GCAs), such as Teaching Games for Understanding, and dynamical systems views of motor learning to demonstrate a convergence of ideas around games as complex adaptive learning systems. This convergence is organized under the title "complexity thinking"…

  16. Complexity

    CERN Document Server

    Gershenson, Carlos

    2011-01-01

    The term complexity derives etymologically from the Latin plexus, which means interwoven. Intuitively, this implies that something complex is composed by elements that are difficult to separate. This difficulty arises from the relevant interactions that take place between components. This lack of separability is at odds with the classical scientific method - which has been used since the times of Galileo, Newton, Descartes, and Laplace - and has also influenced philosophy and engineering. In recent decades, the scientific study of complexity and complex systems has proposed a paradigm shift in science and philosophy, proposing novel methods that take into account relevant interactions.

  17. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry. PMID:23502560

  18. From Hamiltonian chaos to complex systems a nonlinear physics approach

    CERN Document Server

    Leonetti, Marc

    2013-01-01

    From Hamiltonian Chaos to Complex Systems: A Nonlinear Physics Approach collects contributions on recent developments in non-linear dynamics and statistical physics with an emphasis on complex systems. This book provides a wide range of state-of-the-art research in these fields. The unifying aspect of this book is a demonstration of how similar tools coming from dynamical systems, nonlinear physics, and statistical dynamics can lead to a large panorama of  research in various fields of physics and beyond, most notably with the perspective of application in complex systems. This book also: Illustrates the broad research influence of tools coming from dynamical systems, nonlinear physics, and statistical dynamics Adopts a pedagogic approach to facilitate understanding by non-specialists and students Presents applications in complex systems Includes 150 illustrations From Hamiltonian Chaos to Complex Systems: A Nonlinear Physics Approach is an ideal book for graduate students and researchers working in applied...

  19. Combination-Combination Hyperchaos Synchronization of Complex Memristor Oscillator System

    Directory of Open Access Journals (Sweden)

    Zhang Jin-E

    2014-01-01

    Full Text Available The combination-combination synchronization scheme is based on combination of multidrive systems and combination of multiresponse systems. In this paper, we investigate combination-combination synchronization of hyperchaotic complex memristor oscillator system. Several sufficient conditions are provided to ascertain the combination of two drive hyperchaotic complex memristor oscillator systems to synchronize the combination of two response hyperchaotic complex memristor oscillator systems. These new conditions improve and extend the existing synchronization results for memristive systems. A numerical example is given to show the feasibility of theoretical results.

  20. Managing software complexity of adaptive systems

    NARCIS (Netherlands)

    Roo, de Auke Jan

    2012-01-01

    To survive under competitive pressure, embedded system companies build systems that can deal with changing customer needs and operating conditions, and deterioration of the hardware over the lifetime of the embedded system. Engineers face the challenge to design such adaptive systems, while keeping

  1. Exploring subdomain variation in biomedical language

    Directory of Open Access Journals (Sweden)

    Séaghdha Diarmuid Ó

    2011-05-01

    Full Text Available Abstract Background Applications of Natural Language Processing (NLP technology to biomedical texts have generated significant interest in recent years. In this paper we identify and investigate the phenomenon of linguistic subdomain variation within the biomedical domain, i.e., the extent to which different subject areas of biomedicine are characterised by different linguistic behaviour. While variation at a coarser domain level such as between newswire and biomedical text is well-studied and known to affect the portability of NLP systems, we are the first to conduct an extensive investigation into more fine-grained levels of variation. Results Using the large OpenPMC text corpus, which spans the many subdomains of biomedicine, we investigate variation across a number of lexical, syntactic, semantic and discourse-related dimensions. These dimensions are chosen for their relevance to the performance of NLP systems. We use clustering techniques to analyse commonalities and distinctions among the subdomains. Conclusions We find that while patterns of inter-subdomain variation differ somewhat from one feature set to another, robust clusters can be identified that correspond to intuitive distinctions such as that between clinical and laboratory subjects. In particular, subdomains relating to genetics and molecular biology, which are the most common sources of material for training and evaluating biomedical NLP tools, are not representative of all biomedical subdomains. We conclude that an awareness of subdomain variation is important when considering the practical use of language processing applications by biomedical researchers.

  2. Statistical Features of Complex Systems ---Toward Establishing Sociological Physics---

    Science.gov (United States)

    Kobayashi, Naoki; Kuninaka, Hiroto; Wakita, Jun-ichi; Matsushita, Mitsugu

    2011-07-01

    Complex systems have recently attracted much attention, both in natural sciences and in sociological sciences. Members constituting a complex system evolve through nonlinear interactions among each other. This means that in a complex system the multiplicative experience or, so to speak, the history of each member produces its present characteristics. If attention is paid to any statistical property in any complex system, the lognormal distribution is the most natural and appropriate among the standard or ``normal'' statistics to overview the whole system. In fact, the lognormality emerges rather conspicuously when we examine, as familiar and typical examples of statistical aspects in complex systems, the nursing-care period for the aged, populations of prefectures and municipalities, and our body height and weight. Many other examples are found in nature and society. On the basis of these observations, we discuss the possibility of sociological physics.

  3. No Fundamental Limitation on Studying Living Organisms and Other Complex Systems with Statistical Methods

    CERN Document Server

    Thomas, Drew M

    2012-01-01

    Although the state of living organisms is affected by many interrelated and unidentified variables, one need not invoke this to explain the "Truth Wears Off" or "decline" effect, and this complexity imposes no fundamental limitation on statistical inference. Similar "decline" effects occur in physics as well as the biomedical sciences; selective reporting and publication bias, and scientists' biases in favour of reporting eye-catching results (in biomedical sciences and psychology) or conforming to others' results (in physics) better explain this feature of the "Truth Wears Off" effect than Rabin's suggested limitation on statistical inference.

  4. French Roadmap for complex Systems 2008-2009

    OpenAIRE

    Chavalarias, David; Bourgine, Paul; Perrier, Edith; Amblard, Fréderic; Arlabosse, François; Auger, Pierre; Baillon, Jean-Bernard; Barreteau, Olivier; Baudot, Pierre; Bouchaud, Elisabeth; Ben Amor, Soufian; Berry, Hugues; Bertelle, Cyrille; Berthod, Marc; Beslon, Guillaume

    2009-01-01

    This second issue of the French Complex Systems Roadmap by the French National Network for Complex SYstems (http://RNSC.fr) and the Paris Ile-de-France Complex Systems Institute (http://iscpif.fr) is the outcome of the “Entretiens de Cargèse 2008”, an interdisciplinary brainstorming session organized over one week in 2008, jointly by RNSC, ISC-PIF and IXXI. It capitalizes on the first roadmap and gathers contributions of more than 70 scientists from major French institutions. A “complex sy...

  5. Size and complexity in model financial systems

    OpenAIRE

    Arinaminpathy, Nimalan; Kapadia, Sujit; May, Robert

    2012-01-01

    The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification in the financial system? We explore these questions using a deliberately simplified, dynamic model of a banking system that combines three different channels for direct transmis...

  6. Control system for the FFAG complex at KURRI

    International Nuclear Information System (INIS)

    A simple and convenient control system has been developed for the 150 MeV proton FFAG accelerator complex at Research Reactor Institute, Kyoto University. This control system is designed as a distributed control scheme and developed with simple and versatile tools, such as PLCs, LabVIEW and an IP based network, expecting applications in small accelerators, which are often operated by non-specialists in computer programming or in control systems. The control system for the FFAG accelerator complex has actually been developed by non-specialists, and the developed control system was successfully used for commissioning the FFAG complex.

  7. Complexity measure for the Prototype System Description Language (PSDL)

    OpenAIRE

    Dupont, Joseph P.

    2002-01-01

    "We often misunderstand, ill define or improperly measure the complexity of software. Software complexity is represented by the degree of complication of a system determined by such factors as control flow, information flow, the degree of nesting, the types of data structures, and other system characteristics, such as unconventional architectures. However, a common notion of software complexity fulfills a non-functional requirement, that of understandability. How well do we understand the...

  8. Complex Systems: Science for the 21st Century

    Energy Technology Data Exchange (ETDEWEB)

    Shank, Charles V. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Awschalom, David [Univ. of California, Santa Barbara, CA (United States); Bawendi, Moungi [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Frechet, Jean [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Murphy, Donald [Lucent Technologies (United States); Stupp, Sam [Northwestern Univ., Evanston, IL (United States); Wolynes, Peter [Univ. of Illinois, Urbana, IL (United States)

    1999-03-06

    The workshop was designed to help define new scientific directions related to complex systems in order to create new understanding about the nano world and complicated, multicomponent structures. Five emerging themes regarding complexity were covered: Collective Phenomena; Materials by Design; Functional Systems; Nature's Mastery; and New Tools.

  9. Complex, Dynamic Systems: A New Transdisciplinary Theme for Applied Linguistics?

    Science.gov (United States)

    Larsen-Freeman, Diane

    2012-01-01

    In this plenary address, I suggest that Complexity Theory has the potential to contribute a transdisciplinary theme to applied linguistics. Transdisciplinary themes supersede disciplines and spur new kinds of creative activity (Halliday 2001 [1990]). Investigating complex systems requires researchers to pay attention to system dynamics. Since…

  10. Acquisition of Complex Systemic Thinking: Mental Models of Evolution

    Science.gov (United States)

    d'Apollonia, Sylvia T.; Charles, Elizabeth S.; Boyd, Gary M.

    2004-01-01

    We investigated the impact of introducing college students to complex adaptive systems on their subsequent mental models of evolution compared to those of students taught in the same manner but with no reference to complex systems. The students' mental models (derived from similarity ratings of 12 evolutionary terms using the pathfinder algorithm)…

  11. PCA Fault Feature Extraction in Complex Electric Power Systems

    OpenAIRE

    ZHANG, J.; Z. Wang; Zhang, Y.; J. MA

    2010-01-01

    Electric power system is one of the most complex artificial systems in the world. The complexity is determined by its characteristics about constitution, configuration, operation, organization, etc. The fault in electric power system cannot be completely avoided. When electric power system operates from normal state to failure or abnormal, its electric quantities (current, voltage and angles, etc.) may change significantly. Our researches indicate that the variable with the biggest coeffic...

  12. Understanding complex urban systems multidisciplinary approaches to modeling

    CERN Document Server

    Gurr, Jens; Schmidt, J

    2014-01-01

    Understanding Complex Urban Systems takes as its point of departure the insight that the challenges of global urbanization and the complexity of urban systems cannot be understood – let alone ‘managed’ – by sectoral and disciplinary approaches alone. But while there has recently been significant progress in broadening and refining the methodologies for the quantitative modeling of complex urban systems, in deepening the theoretical understanding of cities as complex systems, or in illuminating the implications for urban planning, there is still a lack of well-founded conceptual thinking on the methodological foundations and the strategies of modeling urban complexity across the disciplines. Bringing together experts from the fields of urban and spatial planning, ecology, urban geography, real estate analysis, organizational cybernetics, stochastic optimization, and literary studies, as well as specialists in various systems approaches and in transdisciplinary methodologies of urban analysis, the volum...

  13. A high accuracy broadband measurement system for time resolved complex bioimpedance measurements

    International Nuclear Information System (INIS)

    Bioimpedance measurements are useful tools in biomedical engineering and life science. Bioimpedance is the electrical impedance of living tissue and can be used in the analysis of various physiological parameters. Bioimpedance is commonly measured by injecting a small well known alternating current via surface electrodes into an object under test and measuring the resultant surface voltages. It is non-invasive, painless and has no known hazards. This work presents a field programmable gate array based high accuracy broadband bioimpedance measurement system for time resolved bioimpedance measurements. The system is able to measure magnitude and phase of complex impedances under test in a frequency range of about 10–500 kHz with excitation currents from 10 µA to 5 mA. The overall measurement uncertainties stay below 1% for the impedance magnitude and below 0.5° for the phase in most measurement ranges. Furthermore, the described system has a sample rate of up to 3840 impedance spectra per second. The performance of the bioimpedance measurement system is demonstrated with a resistor based system calibration and with measurements on biological samples. (paper)

  14. ARTIFICIAL LIVING SYSTEM AND ITS COMPLEXITY

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yongguang

    2001-01-01

    In this paper the author shows some artificial living systems, whose basic life characteristics are explored, especially the differentiation in evolution from single cellular to multi-cellular organism. In addition, the author discusses diversity and evolvability also.The author gives a modified entropy function to measure the diversity. Finally, the author drops an open problem about the structure of "gene" of artificial living systems, so that we can measure the evolutionary order between the artificial living systems.

  15. Financial Networks, Complexity and Systemic Risk

    OpenAIRE

    Roukny, Tarik

    2016-01-01

    The recent financial crisis has brought to the fore the need to better understand systemic risk, that is, the risk of collapse of a large part of the financial system and its potential effects on the real economy. In this thesis, we argue that a proper assessment of systemic risk must include an analysis of the network of interdependencies that exists between the different financial institutions. In fact, today's level of financial interconnectedness between and among markets has proven to ha...

  16. Size and complexity in model financial systems.

    Science.gov (United States)

    Arinaminpathy, Nimalan; Kapadia, Sujit; May, Robert M

    2012-11-01

    The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification in the financial system? We explore these questions using a deliberately simplified, dynamic model of a banking system that combines three different channels for direct transmission of contagion from one bank to another: liquidity hoarding, asset price contagion, and the propagation of defaults via counterparty credit risk. Importantly, we also introduce a mechanism for capturing how swings in "confidence" in the system may contribute to instability. Our results highlight that the importance of relatively large, well-connected banks in system stability scales more than proportionately with their size: the impact of their collapse arises not only from their connectivity, but also from their effect on confidence in the system. Imposing tougher capital requirements on larger banks than smaller ones can thus enhance the resilience of the system. Moreover, these effects are more pronounced in more concentrated systems, and continue to apply, even when allowing for potential diversification benefits that may be realized by larger banks. We discuss some tentative implications for policy, as well as conceptual analogies in ecosystem stability and in the control of infectious diseases. PMID:23091020

  17. Size and complexity in model financial systems

    Science.gov (United States)

    Arinaminpathy, Nimalan; Kapadia, Sujit; May, Robert M.

    2012-01-01

    The global financial crisis has precipitated an increasing appreciation of the need for a systemic perspective toward financial stability. For example: What role do large banks play in systemic risk? How should capital adequacy standards recognize this role? How is stability shaped by concentration and diversification in the financial system? We explore these questions using a deliberately simplified, dynamic model of a banking system that combines three different channels for direct transmission of contagion from one bank to another: liquidity hoarding, asset price contagion, and the propagation of defaults via counterparty credit risk. Importantly, we also introduce a mechanism for capturing how swings in “confidence” in the system may contribute to instability. Our results highlight that the importance of relatively large, well-connected banks in system stability scales more than proportionately with their size: the impact of their collapse arises not only from their connectivity, but also from their effect on confidence in the system. Imposing tougher capital requirements on larger banks than smaller ones can thus enhance the resilience of the system. Moreover, these effects are more pronounced in more concentrated systems, and continue to apply, even when allowing for potential diversification benefits that may be realized by larger banks. We discuss some tentative implications for policy, as well as conceptual analogies in ecosystem stability and in the control of infectious diseases. PMID:23091020

  18. Manpower development for the biomedical industry space.

    Science.gov (United States)

    Goh, James C H

    2013-01-01

    The Biomedical Sciences (BMS) Cluster is one of four key pillars of the Singapore economy. The Singapore Government has injected research funding for basic and translational research to attract companies to carry out their commercial R&D activities. To further intensify the R&D efforts, the National Research Foundation (NRF) was set up to coordinate the research activities of different agencies within the larger national framework and to fund strategic R&D initiatives. In recent years, funding agencies began to focus on support of translational and clinical research, particularly those with potential for commercialization. Translational research is beginning to have traction, in particular research funding for the development of innovation medical devices. Therefore, the Biomedical Sciences sector is projected to grow which means that there is a need to invest in human capital development to achieve sustainable growth. In support of this, education and training programs to strengthen the manpower capabilities for the Biomedical Sciences industry have been developed. In recent years, undergraduate and graduate degree courses in biomedical engineering/bioengineering have been developing at a rapid rate. The goal is to train students with skills to understand complex issues of biomedicine and to develop and implement of advanced technological applications to these problems. There are a variety of career opportunities open to graduates in biomedical engineering, however regardless of the type of career choices, students must not only focus on achieving good grades. They have to develop their marketability to employers through internships, overseas exchange programs, and involvement in leadership-type activities. Furthermore, curriculum has to be developed with biomedical innovation in mind and ensure relevance to the industry. The objective of this paper is to present the NUS Bioengineering undergraduate program in relation to manpower development for the biomedical

  19. Big Data Processing in Complex Hierarchical Network Systems

    CERN Document Server

    Polishchuk, Olexandr; Tyutyunnyk, Maria; Yadzhak, Mykhailo

    2016-01-01

    This article covers the problem of processing of Big Data that describe process of complex networks and network systems operation. It also introduces the notion of hierarchical network systems combination into associations and conglomerates alongside with complex networks combination into multiplexes. The analysis is provided for methods of global network structures study depending on the purpose of the research. Also the main types of information flows in complex hierarchical network systems being the basic components of associations and conglomerates are covered. Approaches are proposed for creation of efficient computing environments, distributed computations organization and information processing methods parallelization at different levels of system hierarchy.

  20. The Fallacy of Univariate Solutions to Complex Systems Problems.

    Science.gov (United States)

    Lessov-Schlaggar, Christina N; Rubin, Joshua B; Schlaggar, Bradley L

    2016-01-01

    Complex biological systems, by definition, are composed of multiple components that interact non-linearly. The human brain constitutes, arguably, the most complex biological system known. Yet most investigation of the brain and its function is carried out using assumptions appropriate for simple systems-univariate design and linear statistical approaches. This heuristic must change before we can hope to discover and test interventions to improve the lives of individuals with complex disorders of brain development and function. Indeed, a movement away from simplistic models of biological systems will benefit essentially all domains of biology and medicine. The present brief essay lays the foundation for this argument. PMID:27375425

  1. Complexity in practice: understanding primary care as a complex adaptive system

    Directory of Open Access Journals (Sweden)

    Beverley Ellis

    2010-06-01

    Conclusions The results are real-world exemplars of the emergent properties of complex adaptive systems. Improving clinical governance in primary care requires both complex social interactions and underpinning informatics. The socio-technical lessons learned from this research should inform future management approaches.

  2. Luminescence response of an osmium(II) complex to macromolecular polyanions for the detection of heparin and chondroitin sulfate in biomedical preparations.

    Science.gov (United States)

    Wu, Hao; Wu, Jain; Saez, Christopher; Campana, Maria; Megehee, Elise G; Wang, Enju

    2013-12-01

    Heparin, dextran sulfate (DS), chondroitin sulfate (CS), and carrageenan are found to enhance the luminescence intensity of an osmium(II) carbonyl complex with phenanthroline (phen) and 4-phenylpyridine (4-phpy) ligands in aqueous and ethanol solutions. The enhancing effect of the polyanions on the luminescence of the complex is heavily dependent on the sulfate content and other factors such as structure, solubility, and counter ions of the polyanion. The highly sulfated dextran and ι-carrageenan have the most profound effect, while the low charged κ-carrageenan and CS have the least response in aqueous solution. All polyanions exhibited enhanced luminescence intensity of the complex in ethanol solutions, and even the low charged CS and κ-carrageenan enhanced the luminescence more than 4 times. DS contamination of the sodium heparin at 5% can show a significant increase in luminescence response. The osmium complex is found to be highly successful in the fast and sensitive detection of heparin in commercial injectable samples with various backgrounds as well as the detection of CS in over the counter food supplement tablets. PMID:24267085

  3. Complex systems and networks dynamics, controls and applications

    CERN Document Server

    Yu, Xinghuo; Chen, Guanrong; Yu, Wenwu

    2016-01-01

    This elementary book provides some state-of-the-art research results on broad disciplinary sciences on complex networks. It presents an in-depth study with detailed description of dynamics, controls and applications of complex networks. The contents of this book can be summarized as follows. First, the dynamics of complex networks, for example, the cluster dynamic analysis by using kernel spectral methods, community detection algorithms in bipartite networks, epidemiological modeling with demographics and epidemic spreading on multi-layer networks, are studied. Second, the controls of complex networks are investigated including topics like distributed finite-time cooperative control of multi-agent systems by applying homogenous-degree and Lyapunov methods, composite finite-time containment control for disturbed second-order multi-agent systems, fractional-order observer design of multi-agent systems, chaos control and anticontrol of complex systems via Parrondos game and many more. Third, the applications of ...

  4. Term identification in the biomedical literature.

    Science.gov (United States)

    Krauthammer, Michael; Nenadic, Goran

    2004-12-01

    Sophisticated information technologies are needed for effective data acquisition and integration from a growing body of the biomedical literature. Successful term identification is key to getting access to the stored literature information, as it is the terms (and their relationships) that convey knowledge across scientific articles. Due to the complexities of a dynamically changing biomedical terminology, term identification has been recognized as the current bottleneck in text mining, and--as a consequence--has become an important research topic both in natural language processing and biomedical communities. This article overviews state-of-the-art approaches in term identification. The process of identifying terms is analysed through three steps: term recognition, term classification, and term mapping. For each step, main approaches and general trends, along with the major problems, are discussed. By assessing previous work in context of the overall term identification process, the review also tries to delineate needs for future work in the field. PMID:15542023

  5. Biomedical enhancements as justice.

    Science.gov (United States)

    Nam, Jeesoo

    2015-02-01

    Biomedical enhancements, the applications of medical technology to make better those who are neither ill nor deficient, have made great strides in the past few decades. Using Amartya Sen's capability approach as my framework, I argue in this article that far from being simply permissible, we have a prima facie moral obligation to use these new developments for the end goal of promoting social justice. In terms of both range and magnitude, the use of biomedical enhancements will mark a radical advance in how we compensate the most disadvantaged members of society. PMID:24117708

  6. Biomedical engineering entrepreneurship

    CERN Document Server

    Lee, Jen-Shih

    2014-01-01

    This book is written for undergraduate and graduate students in biomedical engineering wanting to learn how to pursue a career in building up their entrepreneur ventures. Practicing engineers wanting to apply their innovations for healthcare will also find this book useful. The 21st century is the Biotech Century where many nations are investing heavily in biotechnology. As a result, tremendous business opportunities exist for biomedical engineering graduates who are interested in becoming successful entrepreneurs. However, many challenges await these entrepreneurs intending to invent safe and

  7. Quantum dynamics of complex molecular systems

    OpenAIRE

    Miller, William H.

    2005-01-01

    This Perspective presents a broad overview of the present status of theoretical capabilities for describing quantum dynamics in molecular systems with many degrees of freedom, e.g., chemical reactions in solution, clusters, solids, or biomolecular environments.

  8. MODELING AND ANALYSIS OF ENERGY SYSTEM BASED ON COMPLEX ADAPTIVE SYSTEM

    Institute of Scientific and Technical Information of China (English)

    QIU Shiming; GU Peiliang

    2004-01-01

    Complex adaptive system (CAS) is a kind of complex system in natural and artificial systems. In this paper, the theory of complex adaptive system is introduced at first. Considering the characteristic of energy system, it can be regarded as a complex adaptive system. After the evolutionary law is analysed, the energy complex system model is established based on CAS and application tool SWARM, which is a simulation software platform. The model differs from the models as well as methods developed before. As an application, China's energy system is simulated with the model established above.China's future total energy demand in the future, energy structure and related in fiuence on environment are presented.

  9. 5th International Conference on Complex Systems Design & Management

    CERN Document Server

    Krob, Daniel; Morel, Gérard; Roussel, Jean-Claude

    2015-01-01

    This book contains all refereed papers that were accepted to the fifth edition of the « Complex Systems Design & Management » (CSD&M 2014) international conference which took place in Paris (France) on the November 12-14, 2014. These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (aeronautic & aerospace, transportation & systems, defense & security, electronics & robotics, energy & environment, health & welfare services, software & e-services), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, systemic tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSD&M 2014 conference is organized under the guidance of the CESAMES non-profit organization, addres...

  10. Observation-Driven Configuration of Complex Software Systems

    CERN Document Server

    Sage, Aled

    2010-01-01

    The ever-increasing complexity of software systems makes them hard to comprehend, predict and tune due to emergent properties and non-deterministic behaviour. Complexity arises from the size of software systems and the wide variety of possible operating environments: the increasing choice of platforms and communication policies leads to ever more complex performance characteristics. In addition, software systems exhibit different behaviour under different workloads. Many software systems are designed to be configurable so that policies can be chosen to meet the needs of various stakeholders. For complex software systems it can be difficult to accurately predict the effects of a change and to know which configuration is most appropriate. This thesis demonstrates that it is useful to run automated experiments that measure a selection of system configurations. Experiments can find configurations that meet the stakeholders' needs, find interesting behavioural characteristics, and help produce predictive models of...

  11. Complex systems relationships between control, communications and computing

    CERN Document Server

    2016-01-01

    This book gives a wide-ranging description of the many facets of complex dynamic networks and systems within an infrastructure provided by integrated control and supervision: envisioning, design, experimental exploration, and implementation. The theoretical contributions and the case studies presented can reach control goals beyond those of stabilization and output regulation or even of adaptive control. Reporting on work of the Control of Complex Systems (COSY) research program, Complex Systems follows from and expands upon an earlier collection: Control of Complex Systems by introducing novel theoretical techniques for hard-to-control networks and systems. The major common feature of all the superficially diverse contributions encompassed by this book is that of spotting and exploiting possible areas of mutual reinforcement between control, computing and communications. These help readers to achieve not only robust stable plant system operation but also properties such as collective adaptivity, integrity an...

  12. Nonlinear and Complex Dynamics in Real Systems

    OpenAIRE

    William Barnett; Apostolos Serletis; Demitre Serletis

    2005-01-01

    This paper was produced for the El-Naschie Symposium on Nonlinear Dynamics in Shanghai in December 2005. In this paper we provide a review of the literature with respect to fluctuations in real systems and chaos. In doing so, we contrast the order and organization hypothesis of real systems with nonlinear chaotic dynamics and discuss some techniques used in distinguishing between stochastic and deterministic behavior. Moreover, we look at the issue of where and when the ideas of chaos could p...

  13. Metabolic Scaling in Complex Living Systems

    OpenAIRE

    Glazier, Douglas S.

    2014-01-01

    In this review I show that four major kinds of theoretical approaches have been used to explain the scaling of metabolic rate in cells, organisms and groups of organisms in relation to system size. They include models focusing on surface-area related fluxes of resources and wastes (including heat), internal resource transport, system composition, and various processes affecting resource demand, all of which have been discussed extensively for nearly a century or more. I argue that, although e...

  14. Measuring system complexity to support development cost estimates

    Science.gov (United States)

    Malone, P.; Wolfarth, L.

    Systems and System-of-Systems (SoS) are being used more frequently either as a design element of stand alone systems or architectural frameworks. Consequently, a programmatic need has arisen to understand and measure systems complexity in order to estimate more accurately development plans and life-cycle costs. In a prior paper, we introduced the System Readiness Level (SRL) concept as a composite function of both Technology Readiness Levels (TRLs) and Integration Readiness Levels (IRLs) and touched on system complexity. While the SRL approach provides a repeatable, process-driven method to assess the maturity of a system or SoS, it does not capture all aspects of system complexity. In this paper we assess the concept of cyclomatic complexity as a system complexity metric and consider its utility as an approach for estimating the life-cycle costs and cost growth of complex systems. We hypothesize that the greater the number of technologies and integration tasks, the more complex the system and the higher its cost to develop and maintain. We base our analysis on historical data from DoD programs that have experienced significant cost growth, including some that have been cancelled due to unsustainable cost (and schedule) growth. We begin by describing the original implementation of the cyclomatic method, which was developed to estimate the effort to maintain system software. We then describe how the method can be generalized and applied to systems. Next, we show how to estimate the cyclomatic number (CN) and show the statistical significance between a system's CN metric and its cost. We illustrate the method with an example. Last, we discuss opportunities for future research.

  15. Modeling Complex System Correlation Using Detrended Cross-Correlation Coefficient

    OpenAIRE

    2014-01-01

    The understanding of complex systems has become an area of active research for physicists because such systems exhibit interesting dynamical properties such as scale invariance, volatility correlation, heavy tails, and fractality. We here focus on traffic dynamic as an example of a complex system. By applying the detrended cross-correlation coefficient method to traffic time series, we find that the traffic fluctuation time series may exhibit cross-correlation characteristic. Further, we show...

  16. Diagnosis for Control and Decision Support in Complex Systems

    OpenAIRE

    Blanke, Mogens; Hansen, Søren; Blas, Morten Rufus

    2011-01-01

    Diagnosis and, when possible, prognosis of faults are essential for safe and reliable operation. The area of fault diagnosis has emerged over three decades. The majority of studies related to linear systems but real-life systems are complex and nonlinear. The development of methodologies coping with complex and nonlinear systems have matured and even though there are many un-solved problems, methodology and associated tools have become available in the form of theory and software for design. ...

  17. Decision-making in healthcare as a complex adaptive system.

    Science.gov (United States)

    Kuziemsky, Craig

    2016-01-01

    Healthcare transformation requires a change in how the business of healthcare is done. Traditional decision-making approaches based on stable and predictable systems are inappropriate in healthcare because of the complex nature of healthcare delivery. This article reviews challenges to using traditional decision-making approaches in healthcare and how insight from Complex Adaptive Systems (CAS) could support healthcare management. The article also provides a system model to guide decision-making in healthcare as a CAS. PMID:26656389

  18. Eigenfunction Statistics of Complex Systems: A Common Mathematical Formulation

    OpenAIRE

    Shukla, Pragya

    2005-01-01

    We derive a common mathematical formulation for the eigenfunction statistics of Hermitian operators, represented by a multi-parametric probability density. The system-information in the formulation enters through two parameters only, namely, system size and the complexity parameter, a function of all system parameter including size. The behavior is contrary to the eigenvalue statistics which is sensitive to complexity parameter only and shows a single parametric scaling. The existence of a ma...

  19. Complex systems as lenses on learning and teaching

    Science.gov (United States)

    Hurford, Andrew C.

    From metaphors to mathematized models, the complexity sciences are changing the ways disciplines view their worlds, and ideas borrowed from complexity are increasingly being used to structure conversations and guide research on teaching and learning. The purpose of this corpus of research is to further those conversations and to extend complex systems ideas, theories, and modeling to curricula and to research on learning and teaching. A review of the literatures of learning and of complexity science and a discussion of the intersections between those disciplines are provided. The work reported represents an evolving model of learning qua complex system and that evolution is the result of iterative cycles of design research. One of the signatures of complex systems is the presence of scale invariance and this line of research furnishes empirical evidence of scale invariant behaviors in the activity of learners engaged in participatory simulations. The offered discussion of possible causes for these behaviors and chaotic phase transitions in human learning favors real-time optimization of decision-making as the means for producing such behaviors. Beyond theoretical development and modeling, this work includes the development of teaching activities intended to introduce pre-service mathematics and science teachers to complex systems. While some of the learning goals for this activity focused on the introduction of complex systems as a content area, we also used complex systems to frame perspectives on learning. Results of scoring rubrics and interview responses from students illustrate attributes of the proposed model of complex systems learning and also how these pre-service teachers made sense of the ideas. Correlations between established theories of learning and a complex adaptive systems model of learning are established and made explicit, and a means for using complex systems ideas for designing instruction is offered. It is a fundamental assumption of this

  20. Quality assurance of biomedical equipment repair process on technical condition

    OpenAIRE

    Кучеренко, Валентина Леонідівна

    2014-01-01

    Construction of a system of biomedical equipment repair on the actual technical condition is considered, and results of research in this area are given in the paper. The purpose of the research is to analyze the ways of quality assurance of biomedical equipment repair process in transition to the operation on the actual technical condition. Using the methods and means for the repair process stages automation allows to estimate actual technical condition of biomedical equipment. The analysis o...

  1. Synchronizing and controlling hyperchaos in complex Lorentz-Haken systems

    International Nuclear Information System (INIS)

    Synchronizing hyperchaos is realized by the drive-response relationship in the complex Lorentz-Haken system and its higher-order cascading systems for the first time. Controlling hyperchaos is achieved by the intermittent proportional feedback to all of the drive (master) system variables. The complex Lorentz-Haken system describes the detuned single-mode laser and is taken as a typical example of hyperchaotic synchronization to clarify our ideas and results. The ideas and concepts could be extended to some nonlinear dynamical systems and have prospects for potential applications, for example. to laser, electronics, plasma, cryptography, communication, chemical and biological systems and so on. (8 figs., 2 tabs.)

  2. Fourth International Conference on Complex Systems Design & Management

    CERN Document Server

    Boulanger, Frédéric; Krob, Daniel; Marchal, Clotilde

    2014-01-01

    This book contains all refereed papers that were accepted to the fourth edition of the « Complex Systems Design & Management » (CSD&M 2013) international conference which took place in Paris (France) from December 4-6, 2013. These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, e-services), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, systemic tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSD&M 2013 conference is organized under the guidance of the CESAMES non-profit organization

  3. 6th International Conference on Complex Systems Design & Management

    CERN Document Server

    Bocquet, Jean-Claude; Bonjour, Eric; Krob, Daniel

    2016-01-01

    This book contains all refereed papers that were accepted to the sixth edition of the « Complex Systems Design & Management Paris » (CSD&M Paris 2015) international conference which took place in Paris (France) on November 23-25, 2015. These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (aeronautics & aerospace, defense & security, electronics & robotics, energy & environment, health & welfare, software & e-services, transportation), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, systems modeling tools) and systems types (artificial ecosystems, embedded systems, software & information systems, systems of systems, transportation systems). The CSD&M Paris 2015 conference is organized under the guidance of the CESAMES non-profit organization, address...

  4. Discovering independent parameters in complex dynamical systems

    OpenAIRE

    Lainscsek, Claudia; Weyhenmeyer, Jonathan; Sejnowski, Terrence J.; Letellier, Christophe

    2015-01-01

    The transformation of a nonlinear dynamical system into a standard form by using one of its variables and its successive derivatives can be used to identify the relationships that may exist between the parameters of the original system such as the subset of the parameter space over which the dynamics is left invariant. We show how the size of the attractor or the time scale (the pseudo-period) can be varied without affecting the underlying dynamics. This is demonstrated for the Rössler and th...

  5. Theory and model of water resources complex adaptive allocation system

    Institute of Scientific and Technical Information of China (English)

    ZHAOJianshi; WANGZhongjing; WENGWenbin

    2003-01-01

    Complex adaptive system theory is a new and important embranchment of system science,which provides a new thought to research water resources allocation system.Based on the analysis of complexity and complex adaptive mechanism of water resources allocation system,a fire-new analysis model is presented in this paper.With the description of Dynamical mechanism of system,behavior characters of agents and the evalustion method of system status,an integrity research system is built to analyse the evolvement rule of water resources allocation system.And a brief research for the impact of water resources allocation in beneficial regions of the Water Transfer from south to North China Project is conducted.

  6. 基于知识组织系统的生物医学文本挖掘研究%Research on Biomedical Text Mining Based on Knowledge Organization System

    Institute of Scientific and Technical Information of China (English)

    钱庆

    2016-01-01

    With the rapid development of biomedical information technology, biological medical literatures grow exponential y. It's hard to read and understand the required knowledge by manual, how to integrate knowledge from huge amounts of biomedical literatures, mining new knowledge has been becoming the current hot spot. Knowledge organization system construction in the field of biological medicine is more normative and complete than other fields, which is the foundation for biomedical text mining. A large number of text mining methodsand systems based on knowledge organization system have fast development. This paper investigates the existing medical knowledge organization systems and summarizes the process of biomedical text mining. It also summaries the researches andrecentprogressand analyzes the characteristics of biomedical text mining based on knowledge organization system. The knowledge organization systems play an important role in biomedical text mining and the chal enge for the current study are summarized, so as to provide references for biomedical workers.%随着生物医学信息技术的飞速发展,生物医学文献呈“指数型”增长,单纯依靠人工阅读获取和理解所需知识变得异常困难,如何从海量生物医学文献中整合已有知识、挖掘新知识成为当前研究热点。生物医学领域的知识组织系统建设相比其他领域更加规范和完整,为生物医学文本挖掘奠定了基础,大量基于知识组织系统的文本挖掘方法、系统得到快速发展。本文主要梳理现有医学知识组织系统,归纳生物医学文本挖掘的主要流程,按照挖掘任务探讨当前的主要研究和进展情况,并进一步分析基于知识组织系统的生物医学文本挖掘的特点,对知识组织系统在生物医学文本挖掘中发挥的主要作用和当前研究面临的挑战进行总结,以期为生物医学工作者提供借鉴。

  7. Proactive degradation management in complex systems

    International Nuclear Information System (INIS)

    Timely preventive maintenance is of great importance for safety equipment on NPP's. But preventive maintenance becomes complicated when we face systems in where these activities can be performed only during outage period and reactor shutdown must be executed in cause of safety related equipment failure during operation to perform corrective actions. For preventive maintenance strategy degradation monitoring is not always sufficient and degradation trending (extrapolation) should be performed to provide predictability of the extend of degradation and timely preventive or mitigative actions. Degradation trending in proactive maintenance case plays very important role. Current paper is devoted to the analysis and application of mathematical models to the degradation assessment of systems with dependent components. The main attention in present work was paid to the mathematical description of the degradation mechanism. Developed mathematical model allows assess and perform trending of degradation processes during various time moments. Methods can be applied for assessment of various risk estimates of hazardous systems such as systems at nuclear power plants. (author)

  8. TEST QUALITY EVALUATION FOR COMPLEX DIGITAL SYSTEMS

    OpenAIRE

    VLADIMIR HAHANOV; STANLEY HYDUKE; IGOR CHUGUROV

    2003-01-01

    A high performance Back-traced Deductive-Parallel (BDP) fault simulation method based on the superposition procedure is oriented on a using large digital designs processing. Evaluation of RT and gate level design description is proposed in this work. The data structure and program are developed for algorithms realization of proposed method and integration with automatic test pattern generation systems.

  9. Dynamical systems examples of complex behaviour

    CERN Document Server

    Jost, Jürgen

    2005-01-01

    Our aim is to introduce, explain, and discuss the fundamental problems, ideas, concepts, results, and methods of the theory of dynamical systems and to show how they can be used in speci?c examples. We do not intend to give a comprehensive overview of the present state of research in the theory of dynamical systems, nor a detailed historical account of its development. We try to explain the important results, often neglecting technical re?nements 1 and, usually, we do not provide proofs. One of the basic questions in studying dynamical systems, i.e. systems that evolve in time, is the construction of invariants that allow us to classify qualitative types of dynamical evolution, to distinguish between qualitatively di?erent dynamics, and to studytransitions between di?erent types. Itis also important to ?nd out when a certain dynamic behavior is stable under small perturbations, as well as to understand the various scenarios of instability. Finally, an essential aspect of a dynamic evolution is the transformat...

  10. Economic Development and Inequality: a complex system analysis

    OpenAIRE

    Sbardella, Angelica; Pugliese, Emanuele; Pietronero, Luciano

    2016-01-01

    By borrowing methods from complex system analysis, in this paper we analyze the features of the complex relationship that links the development and the industrialization of a country to economic inequality. In order to do this, we identify industrialization as a combination of a monetary index, the GDP per capita, and a recently introduced measure of the complexity of an economy, the Fitness. At first we explore these relations on a global scale over the time period 1990--2008 focusing on two...

  11. Teaching Public Budgeting and Finance as Complex Adaptive System

    OpenAIRE

    Dawoody, Alexander

    2010-01-01

    Complexity studies were nonexistent until the work of Poincare during the period between 1881 and 1886. Poincare‟s work illustrated the first indication of chaotic behavior in a dynamic system. Today, complexity studies extend to vast areas in the fields of natural and social sciences. These studies uncover information of complex nature through paradigms such as interconnectedness, network, process, self-organization, mutual causality, bifurcation, scattered matrix, emergence, collapse dynami...

  12. Ligamentotaxis for complex calcaneal fractures using Joshi's external stabilization system

    OpenAIRE

    Singh, Ajai; Srivastava, RN; Jah, M; Kumar, Ashish

    2008-01-01

    Background: Controversies exist in the literature regarding the management of complex fractures of the calcaneum. We evaluated a series of complex fractures of the calcaneum managed by ligamentotaxis using Joshi's external stabilization system (JESS) for its efficacy. Materials and Methods: Forty-five patients having complex (comminuted, intra-articular fracture with compromised soft tissue condition) fractures of the calcaneum, who were treated by external fixator (JESS) based on the princip...

  13. Statistical Study of Complex Eigenvalues in Stochastic Systems

    Directory of Open Access Journals (Sweden)

    Seifedine Kadry

    2010-05-01

    Full Text Available In this research we analyze the complex modes arising in multiple degree-of-freedom nonproportionally damped discrete linear stochastic systems. The complex eigenvalues intervene when unstable states like resonances, happened. Linear dynamic systems must generally be expected to exhibit non-proportional damping. Non-proportionally damped linear systems do not possess classical normal modes but possess complex modes. The proposed method is based on the transformation of random variables. The advantage of this method which give us the probability density function of real and imaginary part of the complex eigenvalue for stochastic mechanical system, i.e. a system with random output (Young's modulus, load. The proposed method is illustrated by considering numerical example based on a linear array of damped spring-mass oscillators. It is show n that the approach can predict the probability density function with good accuracy when compared with independent Monte-Carlo simulations.

  14. Stability of Rotor Systems: A Complex Modelling Approach

    DEFF Research Database (Denmark)

    Kliem, Wolfhard; Pommer, Christian; Stoustrup, Jakob

    1996-01-01

    A large class of rotor systems can be modelled by a complex matrix differential equation of secondorder. The angular velocity of the rotor plays the role of a parameter. We apply the Lyapunov matrix equation in a complex setting and prove two new stability results which are compared with the...... results of the classical approach using Rayleighquotients. Several rotor systems are tested: a simple Laval rotor, a Laval rotor with additional elasticity and damping in thr bearings, and a number of rotor systems with complex symmetric 4x4 randomly generated matrices....

  15. Large-scale computing techniques for complex system simulations

    CERN Document Server

    Dubitzky, Werner; Schott, Bernard

    2012-01-01

    Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations. The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex systems simulations applications. The intention is to identify new research directions in this field and

  16. Complex fluids in biological systems experiment, theory, and computation

    CERN Document Server

    2015-01-01

    This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solut...

  17. Applications of Complex Systems in Business and Economy

    CERN Document Server

    Kitt, Robert

    2012-01-01

    In this paper the complex systems are discussed from the business and economics point of view. It will be showed and motivated that social systems are typically chaotic and/or non-linear and therefore non-equilibrium or complex systems. It is discussed that the rapid change global consumer behaviour is underway, that further increases the complexity in the business and management. For successful management under complexity, a following principles are offered: openness and international competition, tolerance and variety of the ideas, self-reliability and low dependence on external help. The paper discusses the opportunities and challenges in management under complexity from macro and micro economic perspective. It is motivated that small economies have good prospects to gain from the global processes underway, if they can demonstrate flexible production, reliable business ethics and good risk management. In this environment, the challenges for corporate managements are being also permanently changed: the bala...

  18. Methodology for Measuring the Complexity of Enterprise Information Systems

    Directory of Open Access Journals (Sweden)

    Ilja Holub

    2016-07-01

    Full Text Available The complexity of enterprise information systems is currently a challenge faced not only by IT professionals and project managers, but also by the users of such systems. Current methodologies and frameworks used to design and implement information systems do not specifically deal with the issue of their complexity and, apart from few exceptions, do not at all attempt to simplify the complexity. This article presents the author's own methodology for managing complexity, which can be used to complement any other methodology and which helps limit the growth of complexity. It introduces its own definition and metric of complexity, which it defines as the sum of entities of the individual UML models of the given system, which are selected according to the MMDIS methodology so as to consistently describe all relevant content dimensions of the system. The main objective is to propose a methodology to manage information system complexity and to verify it in practice on a real-life SAP implementation project.

  19. Holography In Biomedical Sciences

    Science.gov (United States)

    von Bally, G.

    1988-01-01

    Today not only physicists and engineers but also biological and medical scientists are exploring the potentials of holographic methods in their special field of work. Most of the underlying physical principles such as coherence, interference, diffraction and polarization as well as general features of holography e.g. storage and retrieval of amplitude and phase of a wavefront, 3-d-imaging, large field of depth, redundant storage of information, spatial filtering, high-resolving, non-contactive, 3-d form and motion analysis are explained in detail in other contributions to this book. Therefore, this article is confined to the applications of holography in biomedical sciences. Because of the great number of contributions and the variety of applications [1,2,3,4,5,6,7,8] in this review the investigations can only be mentioned briefly and the survey has to be confined to some examples. As in all fields of optics and laser metrology, a review of biomedical applications of holography would be incomplete if military developments and their utilization are not mentioned. As will be demonstrated by selected examples the increasing interlacing of science with the military does not stop at domains that traditionally are regarded as exclusively oriented to human welfare like biomedical research [9]. This fact is actually characterized and stressed by the expression "Star Wars Medicine", which becomes increasingly common as popular description for laser applications (including holography) in medicine [10]. Thus, the consequence - even in such highly specialized fields like biomedical applications of holography - have to be discussed.

  20. Implantable CMOS Biomedical Devices

    Directory of Open Access Journals (Sweden)

    Toshihiko Noda

    2009-11-01

    Full Text Available The results of recent research on our implantable CMOS biomedical devices are reviewed. Topics include retinal prosthesis devices and deep-brain implantation devices for small animals. Fundamental device structures and characteristics as well as in vivo experiments are presented.

  1. Biomedical applications in EELA.

    Science.gov (United States)

    Cardenas, Miguel; Hernández, Vicente; Mayo, Rafael; Blanquer, Ignacio; Perez-Griffo, Javier; Isea, Raul; Nuñez, Luis; Mora, Henry Ricardo; Fernández, Manuel

    2006-01-01

    The current demand for Grid Infrastructures to bring collabarating groups between Latina America and Europe has created the EELA proyect. This e-infrastructure is used by Biomedical groups in Latina America and Europe for the studies of ocnological analisis, neglected diseases, sequence alignments and computation plygonetics. PMID:16823158

  2. Biomedical applications of photochemistry

    OpenAIRE

    Chan, BP

    2010-01-01

    Photochemistry is the study of photochemical reactions between light and molecules. Recently, there have been increasing interests in using photochemical reactions in the fields of biomaterials and tissue engineering. This work revisits the components and mechanisms of photochemistry and reviews biomedical applications of photochemistry in various disciplines, including oncology, molecular biology, and biosurgery, with particular emphasis on tissue engineering. Finally, potential toxicities a...

  3. Stripping syntax from complexity: An information-theoretical perspective on complex systems

    CERN Document Server

    Quax, Rick; Thurner, Stefan; Sloot, Peter M A

    2016-01-01

    Claude Shannons information theory (1949) has had a revolutionary impact on communication science. A crucial property of his framework is that it decouples the meaning of a message from the mechanistic details from the actual communication process itself, which opened the way to solve long-standing communication problems. Here we argue that a similar impact could be expected by applying information theory in the context of complexity science to answer long-standing, cross-domain questions about the nature of complex systems. This happens by decoupling the domain-specific model details (e.g., neuronal networks, ecosystems, flocks of birds) from the cross-domain phenomena that characterize complex systems (e.g., criticality, robustness, tipping points). This goes beyond using information theory as a non-linear correlation measure, namely it allows describing a complex system entirely in terms of the storage, transfer, and modification of informational bits. After all, a phenomenon that does not depend on model ...

  4. A Memristor-Based Hyperchaotic ComplexSystem and Its Adaptive Complex Generalized Synchronization

    Directory of Open Access Journals (Sweden)

    Shibing Wang

    2016-02-01

    Full Text Available This paper introduces a new memristor-based hyperchaotic complexsystem (MHCLS and investigates its adaptive complex generalized synchronization (ACGS. Firstly, the complex system is constructed based on a memristor-based hyperchaotic real Lü system, and its properties are analyzed theoretically. Secondly, its dynamical behaviors, including hyperchaos, chaos, transient phenomena, as well as periodic behaviors, are explored numerically by means of bifurcation diagrams, Lyapunov exponents, phase portraits, and time history diagrams. Thirdly, an adaptive controller and a parameter estimator are proposed to realize complex generalized synchronization and parameter identification of two identical MHCLSs with unknown parameters based on Lyapunov stability theory. Finally, the numerical simulation results of ACGS and its applications to secure communication are presented to verify the feasibility and effectiveness of the proposed method.

  5. Managing complex systems: The Labdata case

    OpenAIRE

    Pettersen, Mads Walle

    2014-01-01

    The aim of this master thesis is to explore the organization of a program within Digital Fornying, namely Labdata. The goal of Labdata is to introduce a common, standard, laboratory system for the South-Eastern Norway Regional Health Authority. We compare the organization of Labdata with theoretical concepts from adaptive co-management, Weill & Ross, project and program management. In order to manage this, we have developed the following research question: What are the challenges involved...

  6. Some problems of complex drive system solution

    Czech Academy of Sciences Publication Activity Database

    Kratochvíl, Ctirad; Heriban, P.; Houfek, Lubomír; Houfek, Martin

    Praha : Institute of Thermomechanics AS CR, v. v. i., 2007 - (Zolotarev, I.), s. 131-132 ISBN 978-80-87012-06-2. [Engineering mechanics 2007. Svratka (CZ), 14.05.2007-17.05.2007] R&D Projects: GA ČR GA101/06/0063 Institutional research plan: CEZ:AV0Z20760514 Keywords : drive system * mechanical basic Subject RIV: JR - Other Machinery

  7. Digital System for Complex Bioimpedance Measurement

    Czech Academy of Sciences Publication Activity Database

    Verner, Petr

    Brno : Vysoké učení technické v Brně, 2004 - (Boušek, J.; Háze, J.), s. 149-152 ISBN 80-214-2701-9. [EDS '04 /11./ Electronic Devices and Systems Conference. Brno (CZ), 09.09.2004-10.09.2004] R&D Projects: GA ČR GA102/00/1262 Keywords : bioimpedance measurement * digital receiver * cardiac output Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  8. Theoretical optical spectroscopy of complex systems

    Energy Technology Data Exchange (ETDEWEB)

    Conte, A. Mosca, E-mail: adriano.mosca.conte@roma2.infn.it [MIFP, NAST, ETSF,CNR INFM-SMC, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy); Violante, C., E-mail: claudia.violante@roma2.infn.it [MIFP, NAST, ETSF,CNR INFM-SMC, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy); Missori, M., E-mail: mauro.missori@isc.cnr.it [Istituto dei Sistemi Complessi, Consiglio Nazionale delle Ricerche, Via Salaria Km 29.300, 00016 Monterotondo Scalo (Rome) (Italy); Bechstedt, F., E-mail: bech@ifto.physik.uni-jena.de [Institut fur Festkorpertheorie und -optik, Friedrich-Schiller-Universitat, Max-Wien-Platz 1, 07743 Jena (Germany); Teodonio, L. [MIFP, NAST, ETSF,CNR INFM-SMC, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy); Istituto centrale per il restauro e la conservazione del patrimonio archivistico e librario (IC-RCPAL), Italian Minister for Cultural Heritage, Via Milano 76, 00184 Rome (Italy); Ippoliti, E.; Carloni, P. [German Research School for Simulation Sciences, Julich (Germany); Guidoni, L., E-mail: leonardo.guidoni@univaq.it [Università degli Studi di L’Aquila, Dipartimento di Chimica e Materiali, Via Campo di Pile, 67100 L’Aquila (Italy); Pulci, O., E-mail: olivia.pulci@roma2.infn.it [MIFP, NAST, ETSF,CNR INFM-SMC, Universitá di Roma Tor Vergata, Via della Ricerca Scientifica 1, Roma (Italy)

    2013-08-15

    Highlights: ► We review some theoretical condensed matter ab initio spectroscopic computational techniques. ► We show several applications ranging from 0 to 3 dimensional systems. ► For each system studied, we show which kind of information it is possible to obtain by performing these calculations. -- Abstract: We review here some of the most reliable and efficient computational theoretical ab initio techniques for the prediction of optical and electronic spectroscopic properties and show some important applications to molecules, surfaces, and solids. We investigate the role of the solvent in the optical absorption spectrum of indole molecule. We study the excited-state properties of a photo-active minimal model molecule for the retinal of rhodopsin, responsible for vision mechanism in animals. We then show a study about spectroscopic properties of Si(1 1 1) surface. Finally we simulate a bulk system: paper, that is mainly made of cellulose, a pseudo-crystalline material representing 40% of annual biomass production in the Earth.

  9. Computer aided operation of complex systems

    International Nuclear Information System (INIS)

    Advanced technology is having the effect that industrial systems are becoming more highly automated and do not rely on human intervention for the control of normally planned and/or predicted situations. Thus the importance of the operator has shifted from being a manual controller to becoming more of a systems manager and supervisory controller. At the same time, the use of advanced information technology in the control room and its potential impact on human-machine capabilities places additional demands on the designer. This report deals with work carried out to describe the plant-operator relationship in order to systematize the design and evaluation of suitable information systems in the control room. This design process starts with the control requirements from the plant and transforms them into corresponding sets of decision-making tasks with appropriate allocation of responsibilities between computer and operator. To further effectivize this cooperation, appropriate information display and accession are identified. The conceptual work has been supported by experimental studies on a small-scale simulator. (author)

  10. Theoretical optical spectroscopy of complex systems

    International Nuclear Information System (INIS)

    Highlights: ► We review some theoretical condensed matter ab initio spectroscopic computational techniques. ► We show several applications ranging from 0 to 3 dimensional systems. ► For each system studied, we show which kind of information it is possible to obtain by performing these calculations. -- Abstract: We review here some of the most reliable and efficient computational theoretical ab initio techniques for the prediction of optical and electronic spectroscopic properties and show some important applications to molecules, surfaces, and solids. We investigate the role of the solvent in the optical absorption spectrum of indole molecule. We study the excited-state properties of a photo-active minimal model molecule for the retinal of rhodopsin, responsible for vision mechanism in animals. We then show a study about spectroscopic properties of Si(1 1 1) surface. Finally we simulate a bulk system: paper, that is mainly made of cellulose, a pseudo-crystalline material representing 40% of annual biomass production in the Earth

  11. Critical care nursing: Embedded complex systems.

    Science.gov (United States)

    Trinier, Ruth; Liske, Lori; Nenadovic, Vera

    2016-01-01

    Variability in parameters such as heart rate, respiratory rate and blood pressure defines healthy physiology and the ability of the person to adequately respond to stressors. Critically ill patients have lost this variability and require highly specialized nursing care to support life and monitor changes in condition. The critical care environment is a dynamic system through which information flows. The critical care unit is typically designed as a tree structure with generally one attending physician and multiple nurses and allied health care professionals. Information flow through the system allows for identification of deteriorating patient status and timely interventionfor rescue from further deleterious effects. Nurses provide the majority of direct patient care in the critical care setting in 2:1, 1:1 or 1:2 nurse-to-patient ratios. The bedside nurse-critically ill patient relationship represents the primary, real-time feedback loop of information exchange, monitoring and treatment. Variables that enhance information flow through this loop and support timely nursing intervention can improve patient outcomes, while barriers can lead to errors and adverse events. Examining patient information flow in the critical care environment from a dynamic systems perspective provides insights into how nurses deliver effective patient care and prevent adverse events. PMID:27047997

  12. Research Methodology on Language Development from a Complex Systems Perspective

    Science.gov (United States)

    Larsen-Freeman, Diane; Cameron, Lynne

    2008-01-01

    Changes to research methodology motivated by the adoption of a complexity theory perspective on language development are considered. The dynamic, nonlinear, and open nature of complex systems, together with their tendency toward self-organization and interaction across levels and timescales, requires changes in traditional views of the functions…

  13. Vertical leadership in highly complex and unpredictable health systems.

    Science.gov (United States)

    Till, Alex; Dutta, Nina; McKimm, Judy

    2016-08-01

    This article explores how the concept of vertical leadership development might help health organizations cope with and thrive within highly complex and unpredictable health systems, looking at concepts of VUCA (volatility, uncertainty, complexity and ambiguity) and RUPT (rapid, unpredictable, paradoxical and tangled). PMID:27487058

  14. Classrooms as Complex Adaptive Systems: A Relational Model

    Science.gov (United States)

    Burns, Anne; Knox, John S.

    2011-01-01

    In this article, we describe and model the language classroom as a complex adaptive system (see Logan & Schumann, 2005). We argue that linear, categorical descriptions of classroom processes and interactions do not sufficiently explain the complex nature of classrooms, and cannot account for how classroom change occurs (or does not occur), over…

  15. Understanding Learner Agency as a Complex Dynamic System

    Science.gov (United States)

    Mercer, Sarah

    2011-01-01

    This paper attempts to contribute to a fuller understanding of the nature of language learner agency by considering it as a complex dynamic system. The purpose of the study was to explore detailed situated data to examine to what extent it is feasible to view learner agency through the lens of complexity theory. Data were generated through a…

  16. On the Descriptional Complexity of Limited Propagating Lindenmayer Systems

    Directory of Open Access Journals (Sweden)

    Bianca Truthe

    2010-08-01

    Full Text Available We investigate the descriptional complexity of limited propagating Lindenmayer systems and their deterministic and tabled variants with respect to the number of rules and the number of symbols. We determine the decrease of complexity when the generative capacity is increased. For incomparable families, we give languages that can be described more efficiently in either of these families than in the other.

  17. On the Descriptional Complexity of Limited Propagating Lindenmayer Systems

    OpenAIRE

    Bianca Truthe

    2010-01-01

    We investigate the descriptional complexity of limited propagating Lindenmayer systems and their deterministic and tabled variants with respect to the number of rules and the number of symbols. We determine the decrease of complexity when the generative capacity is increased. For incomparable families, we give languages that can be described more efficiently in either of these families than in the other.

  18. 3rd International Conference on Nanotechnologies and Biomedical Engineering

    CERN Document Server

    Tiginyanu, Ion

    2016-01-01

    This volume presents the proceedings of the 3rd International Conference on Nanotechnologies and Biomedical Engineering which was held on September 23-26, 2015 in Chisinau, Republic of Moldova. ICNBME-2015 continues the series of International Conferences in the field of nanotechnologies and biomedical engineering. It aims at bringing together scientists and engineers dealing with fundamental and applied research for reporting on the latest theoretical developments and applications involved in the fields. Topics include Nanotechnologies and nanomaterials Plasmonics and metamaterials Bio-micro/nano technologies Biomaterials Biosensors and sensors systems Biomedical instrumentation Biomedical signal processing Biomedical imaging and image processing Molecular, cellular and tissue engineering Clinical engineering, health technology management and assessment; Health informatics, e-health and telemedicine Biomedical engineering education Nuclear and radiation safety and security Innovations and technology transfer...

  19. Communication and control for networked complex systems

    CERN Document Server

    Peng, Chen; Han, Qing-Long

    2015-01-01

    This book reports on the latest advances in the study of Networked Control Systems (NCSs). It highlights novel research concepts on NCSs; the analysis and synthesis of NCSs with special attention to their networked character; self- and event-triggered communication schemes for conserving limited network resources; and communication and control co-design for improving the efficiency of NCSs. The book will be of interest to university researchers, control and network engineers, and graduate students in the control engineering, communication and network sciences interested in learning the core principles, methods, algorithms and applications of NCSs.

  20. AN ADVANCED SYSTEM FOR POLLUTION PREVENTION IN CHEMICAL COMPLEXES

    Science.gov (United States)

    One important accomplishment is that the system will give process engineers interactively and simultaneously use of programs for total cost analysis, life cycle assessment and sustainability metrics to provide direction for the optimal chemical complex analysis pro...

  1. Distributed Diagnosis, Prognosis and Recovery for Complex Systems Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Complex space systems such as lunar habitats generate huge amounts of data. For example, the International Space Station (ISS) has over 250,000 individually...

  2. Lie and Noether symmetries of systems of complex ordinary differential equations and their split systems

    Indian Academy of Sciences (India)

    R Naz; F M Mahomed

    2014-07-01

    The Lie and Noether point symmetry analyses of a th-order system of complex ordinary differential equations (ODEs) with dependent variables are performed. The decomposition of complex symmetries of the given system of complex ODEs yields Lie- and Noether-like operators. The system of complex ODEs can be split into 2 coupled real partial differential equations (PDEs) and 2 Cauchy–Riemann (CR) equations. The classical approach is invoked to compute the symmetries of the 4 real PDEs and these are compared with the decomposed Lie- and Noetherlike operators of the system of complex ODEs. It is shown that, in general, the Lie- and Noether-like operators of the system of complex ODEs and the symmetries of the decomposed system of real PDEs are not the same. A similar analysis is carried out for restricted systems of complex ODEs that split into 2 coupled real ODEs. We summarize our findings on restricted complex ODEs in two propositions.

  3. Micro and Nano Manipulations for Biomedical Applications

    CERN Document Server

    Yih, Tachung C

    2007-01-01

    Taking bio-device research and development to "the next level," this book covers the latest advances in biomedical microelectromechanical systems (MEMS) and nanoelectromechanical systems (NEMS). The book presents new developments in the synthesis and use of metallic nanoparticles in bio-sensing and drug delivery, including quantum dots semiconductors nanocrystals.

  4. A simple framework for complex system improvement.

    Science.gov (United States)

    Kraft, Sally; Carayon, Pascale; Weiss, Jennifer; Pandhi, Nancy

    2015-05-01

    The need to rapidly improve health care value is unquestioned, but the means to accomplish this task is unknown. Improving performance at the level of the health care organization frequently involves multiple interventions, which must be coordinated and sequenced to fit the specific context. Those responsible for achieving large-scale improvements are challenged by the lack of a framework to describe and organize improvement strategies. Drawing from the fields of health services, industrial engineering, and organizational behavior, a simple framework was developed and has been used to guide and evaluate improvement initiatives at an academic health center. The authors anticipate that this framework will be helpful for health system leaders responsible for improving health care quality. PMID:24723664

  5. 1st International Workshop on Complex Systems in Sports - Proceedings

    OpenAIRE

    Guervós, Juan Julián Merelo; Cotta, Carlos; Mora, Antonio M.

    2011-01-01

    Online proceedings for the first workshop on complex systems in sports; index pointing to the papers that will be presented and discussed in that workshop. The papers deal with sports from a complex systems point of view, and include papers on a network analysis of the performance of the Spanish team in the 2010 world cup and basketball scoring, study of populations of sports fans, try to select attributes for sports forecasting and finally try to analyze the physical condition from the persp...

  6. Summer School Mathematical Foundations of Complex Networked Information Systems

    CERN Document Server

    Fosson, Sophie; Ravazzi, Chiara

    2015-01-01

    Introducing the reader to the mathematics beyond complex networked systems, these lecture notes investigate graph theory, graphical models, and methods from statistical physics. Complex networked systems play a fundamental role in our society, both in everyday life and in scientific research, with applications ranging from physics and biology to economics and finance. The book is self-contained, and requires only an undergraduate mathematical background.

  7. Supply Chain as Complex Adaptive System and Its Modeling

    Institute of Scientific and Technical Information of China (English)

    MingmingWang

    2004-01-01

    Supply chain is a complex, hierarchical, integrated, open and dynamic network.Every node in the network is an independent business unit that unites other organizations to develop its value, the competition and cooperation between these units are basic impetus of the development and evolution of the supply chain system. The characteristics of supply chain as a complex adaptive system and its modeling are discussed in this paper, and use an example demonstrating the feasibility of CAS modeling in supply chain management study.

  8. Approximate entropy as a measure of system complexity.

    OpenAIRE

    Pincus, S M

    1991-01-01

    Techniques to determine changing system complexity from data are evaluated. Convergence of a frequently used correlation dimension algorithm to a finite value does not necessarily imply an underlying deterministic model or chaos. Analysis of a recently developed family of formulas and statistics, approximate entropy (ApEn), suggests that ApEn can classify complex systems, given at least 1000 data values in diverse settings that include both deterministic chaotic and stochastic processes. The ...

  9. A Measure for Complex Dynamics in Power Systems

    Directory of Open Access Journals (Sweden)

    Ralph Wilson

    2011-06-01

    Full Text Available In an attempt to quantify the dynamical complexity of power systems, we introduce the use of a non-linear time series technique to detect complex dynamics in a signal. The technique is a significant reinterpretation of the Approximate Entropy (ApEn introduced by Pincus, as an approximation to the Eckmann- Ruelle entropy. It is examined in the context of power systems, and several examples are explored.

  10. Obesity, Complexity, and the Role of the Health System

    OpenAIRE

    Frood, Sarah; Johnston, Lee M.; Matteson, Carrie L.; Finegood, Diane T.

    2013-01-01

    As obesity continues to increase throughout the world, there is still no well-defined solution to the issue. Reducing obesity poses a significant challenge for the health care system because it is a complex problem with numerous interconnections and elements. The complexity of obesity challenges traditional primary care practices that have been structured to address simple or less complicated conditions. Systems thinking provides a way forward for clinicians that are discouraged or overwhelme...

  11. Advertising, product quality, and complex evolving marketing systems

    OpenAIRE

    Verbeke, Willem

    1992-01-01

    textabstractThe paper analyses the advertising as power vs. advertising as information controversy as well as its recent empirical testing. It is stressed that this distinction focuses too much on the interaction between consumer and manufacturer while ignoring the retailer as an important stake-holder. To compensate for this lack, a complex marketing system perspective is introduced in which consumer, retailer, and manufacturer interact. However, these complex marketing systems might drift t...

  12. Software Testing Strategy: In Conversion of Complex Financial Systems

    OpenAIRE

    Fatma Molu

    2014-01-01

    Complex financial conversion projects with large budgets have many different challenges. For companies that want to survive in conditions of tough competition, legacy (old) systems must continue to provide the required service throughout the project life cycle and in some circumstances even after project completion partly. In this case, the term coexistence comes into prominence. During this period, testing phase takes more critical role while integration systems' complexity and risk amount i...

  13. Safety control program for complex system based on behavior science

    Institute of Scientific and Technical Information of China (English)

    LIANG Mei-jian; YANG Guang; CHEN Da-wei

    2008-01-01

    To control complex system's safety effectively, safety control program was supported based on the principles of behavioral science that shapes organizational be-havior, and organizational behavior produced individual behavior. The program can be structured into a model that consists of three modules including individual behavior rectifi-cation, organization behavior diagnosis and model of safety culture. The research result not only reveals the deep cause of complex system accidents but also provides structural descriptions with the accidents cause.

  14. Safety control program for complex system based on behavior science

    Institute of Scientific and Technical Information of China (English)

    LIANG Mei-jian; YANG Guang; CHEN Da-wei

    2008-01-01

    To control complex system's safety effectively,safety control program was supported based on the principles of behavioral science that shapes organizational behavior,and organizational behavior produced individual behavior.The program can be structured into a model that consists of three modules including individual behavior rectification,organization behavior diagnosis and model of safety culture.The research result not only reveals the deep cause of complex system accidents but also provides structural descriptions with the accidents cause.

  15. From the complex system leadership perspective: DNA leadership

    Directory of Open Access Journals (Sweden)

    Hasan Basri Gündüz

    2011-01-01

    Full Text Available Traditional leadership models are based on the paradigm of bureaucratic top-down administration. These models were suitable for industrial societies and organizations. However, the complex and quickly changing structure of information societies and because market conditions become more and more challenging conditions require different and more flexible organizational structures and leadership approaches. Complexity leadership approach is one of the approaches that were put forward to meet these needs. This approach suggests a new paradigm for leadership, and leadership is defined as a complex interactive dynamic from which adaptive outcomes (learning, innovation, and adaptability emerge.  Multi-cellular higher organisms are complex systems like information societies. In this context, DNA that leads the processes in multi-cellular higher organisms may be taken as a metaphor for leadership. In this study, considering the functions and role of DNA in a cell, the concept of DNA leadership was discussed from the complex system leadership perspective.

  16. Recording information on protein complexes in an information management system

    Science.gov (United States)

    Savitsky, Marc; Diprose, Jonathan M.; Morris, Chris; Griffiths, Susanne L.; Daniel, Edward; Lin, Bill; Daenke, Susan; Bishop, Benjamin; Siebold, Christian; Wilson, Keith S.; Blake, Richard; Stuart, David I.; Esnouf, Robert M.

    2011-01-01

    The Protein Information Management System (PiMS) is a laboratory information management system (LIMS) designed for use with the production of proteins in a research environment. The software is distributed under the CCP4 licence, and so is available free of charge to academic laboratories. Like most LIMS, the underlying PiMS data model originally had no support for protein–protein complexes. To support the SPINE2-Complexes project the developers have extended PiMS to meet these requirements. The modifications to PiMS, described here, include data model changes, additional protocols, some user interface changes and functionality to detect when an experiment may have formed a complex. Example data are shown for the production of a crystal of a protein complex. Integration with SPINE2-Complexes Target Tracker application is also described. PMID:21605682

  17. Design and optimization of a 3-coil resonance-based wireless power transfer system for biomedical implants

    KAUST Repository

    Yi, Ying

    2014-09-01

    This paper presents a resonance-based wireless power transfer system using a single layer of inductor coil windings, in a pancake configuration, in order to obtain a compact system for implantable electronic applications. We theoretically analyzed the system and characterized it by measuring its inductance, self-resonant frequency, and quality factor Q. In our resonance-based wireless power transfer prototype, we proposed a 3-coil system, using two 15-mm radius implantable coils, with a resonance frequency of 6.76MHz. This system can effectively transfer power for a distance of up to 50mm. Moreover, our proposed 3-coil system can achieve a high Q-factor and has a comparable power transfer efficiency (PTE) to previously reported works about 3-coil and 4-coil systems. The experimental PTE can achieve 82.4% at a separation distance of 20mm and more than 10% PTE at a distance of 40mm.

  18. An ensemble approach to the evolution of complex systems

    Indian Academy of Sciences (India)

    Göker Arpağ; Ayşe Erzan

    2014-04-01

    Adaptive systems frequently incorporate complex structures which can arise spontaneously and which may be non-adaptive in the evolutionary sense. We give examples from phase transition and fractal growth to develop the themes of cooperative phenomena and pattern formation. We discuss RNA interference and transcriptional gene regulation networks, where a major part of the topological properties can be accounted for by mere combinatorics. A discussion of ensemble approaches to biological systems and measures of complexity is presented, and a connection is established between complexity and fitness.

  19. Hybrid synchronization of two independent chaotic systems on complex network

    Indian Academy of Sciences (India)

    NIAN FUZHONG; LIU WEILONG

    2016-06-01

    The real network nodes are always interfered by other messages. So, how to realize the hybrid synchronization of two independent chaotic systems based on the complex network is very important. To solve this problem, two other problems should be considered. One is how the same network node of the complex network was affected by different information sources. Another is how to achieve hybrid synchronization on the network. In this paper, the theoretical analysis andnumerical simulation on various complex networks are implemented. The results indicate that the hybrid synchronization of two independent chaotic systems is feasible.

  20. An ensemble approach to the evolution of complex systems.

    Science.gov (United States)

    Arpağ, Göker; Erzan, Ayşe

    2014-04-01

    Adaptive systems frequently incorporate complex structures which can arise spontaneously and which may be nonadaptive in the evolutionary sense. We give examples from phase transition and fractal growth to develop the themes of cooperative phenomena and pattern formation. We discuss RNA interference and transcriptional gene regulation networks, where a major part of the topological properties can be accounted for by mere combinatorics. A discussion of ensemble approaches to biological systems and measures of complexity is presented, and a connection is established between complexity and fitness. PMID:24736159