WorldWideScience

Sample records for biology moving fluids

  1. Cosmology with moving bimetric fluids

    CERN Document Server

    García-García, Carlos; Martín-Moruno, Prado

    2016-01-01

    We study cosmological implications of bigravity and massive gravity solutions with non-simultaneously diagonal metrics by considering the generalized Gordon and Kerr-Schild ansatzes. The scenario that we obtain is equivalent to that of General Relativity with additional non-comoving perfect fluids. We show that the most general ghost-free bimetric theory generates three kinds of effective fluids whose equations of state are fixed by a function of the ansatz. Different choices of such function allow to reproduce the behaviour of different dark fluids. In particular, the Gordon ansatz is suitable for the description of various kinds of slowly-moving fluids, whereas the Kerr-Schild one is shown to describe a null dark energy component. The motion of those dark fluids with respect to the CMB is shown to generate, in turn, a relative motion of baryonic matter with respect to radition which contributes to the CMB anisotropies. CMB dipole observations are able to set stringent limits on the dark sector described by ...

  2. Cosmology with moving bimetric fluids

    OpenAIRE

    García-García, Carlos; Maroto, Antonio L.; Martín-Moruno, Prado

    2016-01-01

    We study cosmological implications of bigravity and massive gravity solutions with non-simultaneously diagonal metrics by considering the generalized Gordon and Kerr-Schild ansatzes. The scenario that we obtain is equivalent to that of General Relativity with additional non-comoving perfect fluids. We show that the most general ghost-free bimetric theory generates three kinds of effective fluids whose equations of state are fixed by a function of the ansatz. Different choices of such function...

  3. Microgravity Fluids for Biology, Workshop

    Science.gov (United States)

    Griffin, DeVon; Kohl, Fred; Massa, Gioia D.; Motil, Brian; Parsons-Wingerter, Patricia; Quincy, Charles; Sato, Kevin; Singh, Bhim; Smith, Jeffrey D.; Wheeler, Raymond M.

    2013-01-01

    Microgravity Fluids for Biology represents an intersection of biology and fluid physics that present exciting research challenges to the Space Life and Physical Sciences Division. Solving and managing the transport processes and fluid mechanics in physiological and biological systems and processes are essential for future space exploration and colonization of space by humans. Adequate understanding of the underlying fluid physics and transport mechanisms will provide new, necessary insights and technologies for analyzing and designing biological systems critical to NASAs mission. To enable this mission, the fluid physics discipline needs to work to enhance the understanding of the influence of gravity on the scales and types of fluids (i.e., non-Newtonian) important to biology and life sciences. In turn, biomimetic, bio-inspired and synthetic biology applications based on physiology and biology can enrich the fluid mechanics and transport phenomena capabilities of the microgravity fluid physics community.

  4. Multiphase flow of immiscible fluids on unstructured moving meshes

    OpenAIRE

    Misztal, Marek Krzysztof; Erleben, Kenny; Bargteil, Adam; Fursund, Jens; Christensen , Brian Bunch; Bærentzen, Jakob Andreas; Bridson, Robert

    2012-01-01

    In this paper, we present a method for animating multiphase flow of immiscible fluids using unstructured moving meshes. Our underlying discretization is an unstructured tetrahedral mesh, the deformable simplicial complex (DSC), that moves with the flow in a Lagrangian manner. Mesh optimization operations improve element quality and avoid element inversion. In the context of multiphase flow, we guarantee that every element is occupied by a single fluid and, consequently, the interface between ...

  5. Finite size fluid particle in nonuniform moving grid

    International Nuclear Information System (INIS)

    The particle-in-cell (PIC) method, which is known as mixed Eulerian-Lagrangian scheme, has been applied successfully to solve a wide variety of problems in which the fluid distortion is large. In this paper, a new type of the PIC method is presented. Area-weighting technique and a nonuniform-spacing, moving grid were employed for the suppression of nonphysical fluctuation and for the description of large density variation with few particles, respectively. The reduction of numerical viscosity is discussed. In a basic scheme, the equations for one compressible fluid were used. In the present approach to the PIC method, a particle has the memories for its own mass, position and internal energy, but momentum is attached to the particle only when it moves, in order to evade the multistreaming problem. An essential point is that a particle preserves the memory of the cell boundary lines when it moves. As the examples, one-dimensional adiabatic expansion process and the Rayleigh-Taylor instability were analyzed. The results showed that the new PIC method is useful for the description of large density variation with few particles as well as for the cases known to be powerful in Harlow's PIC method. Nonphysical noise, numerical thermal diffusion and viscosity were successfully reduced. A nonuniformly-spacing, moving grid system can be used for the local fine resolution of processes. (Kato, T.)

  6. Jets generated by a sphere moving vertically in stratified fluids

    Science.gov (United States)

    Hanazaki, Hideshi; Okino, Shinya; Nakamura, Shota; Akiyama, Shinsaku

    2013-11-01

    Unsteady development of buoyant jets generated by a sphere moving vertically at constant speeds in stratified fluids is investigated. Initially, the sphere simply drags light upper fluids or isopycnal surfaces as it goes down, as long as the molecular diffusion of density is negligible. In the succeeding period, molecular diffusion of density in the boundary layer on the sphere surface becomes increasingly significant, especially in the lower hemisphere. Then, the density is no longer conserved and a vertical jet starts from the rear/upper stagnation point of the sphere, since the fluid particle of altered but small density tends to go back to its original height. Strength and radius of those jets depend significantly on stratification (Froude number), as well as the Reynolds number and the Schmidt number. These mechanisms are investigated by numerical simulations and measurements by laser induced fluorescence (LIF).

  7. Adaptive thermo-fluid moving boundary computations for interfacial dynamics

    Institute of Scientific and Technical Information of China (English)

    Chih-Kuang Kuan; Jaeheon Sim; Wei Shyy

    2012-01-01

    In this study,we present adaptive moving boundary computation technique with parallel implementation on a distributed memory multi-processor system for large scale thermo-fluid and interfacial flow computations.The solver utilizes Eulerian-Lagrangian method to track moving (Lagrangian) interfaces explicitly on the stationary (Eulerian)Cartesian grid where the flow fields are computed. We address the domain decomposition strategies of EulerianLagrangian method by illustrating its intricate complexity of the computation involved on two different spaces interactively and consequently,and then propose a trade-off approach aiming for parallel scalability.Spatial domain decomposition is adopted for both Eulerian and Lagrangian domain due to easy load balancing and data locality for minimum communication between processors.In addition,parallel cell-based unstructured adaptive mesh refinement (AMR)technique is implemented for the flexible local refinement and even-distributed computational workload among processors.Selected cases are presented to highlight the computational capabilities,including Faraday type interfacial waves with capillary and gravitational forcing,flows around varied geometric configurations and induced by boundary conditions and/or body forces,and thermo-fluid dynamics with phase change.With the aid of the present techniques,large scale challenging moving boundary problems can be effectively addressed.

  8. Biological Phosphorus Removal in a Moving Bed Biofilm Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Helness, Herman

    2007-09-15

    The scope of this study was to investigate use of the moving bed biofilm reactor (MBBR) process for biological phosphorus removal. The goal has been to describe the operating conditions required for biological phosphorus and nitrogen removal in a MBBR operated as a sequencing batch reactor (SBR), and determine dimensioning criteria for such a process

  9. Multiphase Flow of Immiscible Fluids on Unstructured Moving Meshes

    DEFF Research Database (Denmark)

    Misztal, Marek Krzysztof; Erleben, Kenny; Bargteil, Adam;

    2012-01-01

    by a majority of fluid simulation techniques that use tetrahedral meshes. We characterize fluid simulation as an optimization problem allowing for full coupling of the pressure and velocity fields and the incorporation of a second-order surface energy. We introduce a preconditioner based on the diagonal Schur...... complement and solve our optimization on the GPU. We provide the results of parameter studies as well as a performance analysis of our method....

  10. Multiphase Flow of Immiscible Fluids on Unstructured Moving Meshes

    DEFF Research Database (Denmark)

    Misztal, Marek Krzysztof; Erleben, Kenny; Bargteil, Adam;

    2013-01-01

    by a majority of fluid simulation techniques that use tetrahedral meshes. We characterize fluid simulation as an optimization problem allowing for full coupling of the pressure and velocity fields and the incorporation of a second-order surface energy. We introduce a preconditioner based on the diagonal Schur...... complement and solve our optimization on the GPU. We provide the results of parameter studies as well as a performance analysis of our method, together with suggestions for performance optimization....

  11. Multiphase flow of immiscible fluids on unstructured moving meshes

    DEFF Research Database (Denmark)

    Misztal, Marek Krzysztof; Erleben, Kenny; Bargteil, Adam;

    2012-01-01

    by a majority of fluid simulation techniques that use tetrahedral meshes. We characterize fluid simulation as an optimization problem allowing for full coupling of the pressure and velocity fields and the incorporation of a second-order surface energy. We introduce a preconditioner based on the diagonal Schur...... complement and solve our optimization on the GPU. We provide the results of parameter studies as well as a performance analysis of our method....

  12. Interactions between kinetic and radiative processes inside moving absorbing fluids

    Energy Technology Data Exchange (ETDEWEB)

    Fumeron, S. [Departement des Sciences Appliquees, Groupe de Recherche en Ingenierie des Procedes et Systemes, P4-3240, CURAL, Universite du Quebec a Chicoutimi, 555 Boulevard de l' Universite, Chicoutimi, Que., G7H 2B1 (Canada); Charette, A. [Departement des Sciences Appliquees, Groupe de Recherche en Ingenierie des Procedes et Systemes, P4-3240, CURAL, Universite du Quebec a Chicoutimi, 555 Boulevard de l' Universite, Chicoutimi, Que., G7H 2B1 (Canada)]. E-mail: andre_charette@uqac.ca; Ben-Abdallah, P. [Laboratoire de Thermocinetique, UMR CNRS 6607, Ecole Polytechnique, Site de la Chantrerie, 44 306 Nantes Cedex (France)

    2006-01-15

    The aim of this paper is to present several features of the couplings occurring between radiative transfer and the kinetics of a moving dielectric. After determining how the velocity field affects the apparent thermo-optical properties of matter, the energy transport problem is investigated in instationary regime and the general form of transient radiative transfer equation inside a moving medium is built. Then, the model is applied to the particular case of turbulent flows: a system of two equations for mean and fluctuating radiative energies is presented, and the resolution of this system is finally carried out.

  13. Experimental study on moving boundaries of fluid flow in porous media

    Institute of Scientific and Technical Information of China (English)

    ZHOU HongWei; ZHANG YaHeng; LI AiMin; QIU DaYong

    2008-01-01

    Researches on the boundary shape of fluid flow in porous media play an important role in engineering practices,such as petroleum exploitation,nuclear waste disposal and groundwater contamination.In this paper,six types of artificial porous samples (emery jade) with different porosities are manufactured.With the background of slow flow in porous media,laboratory experiments are carried out by observing the movement of five types of fluids with different dynamic viscosities in various types of porous media.A digital video recorder is employed to record the complete process of the fluid flow in the porous media.Based on the digital photos of the moving boundaries of fluid flow in porous media,the average displacement and fractal dimension of the moving boundary are estimated for different combinations of porosity and dynamic viscosity.Moreover,the evolution behavior of the average velocity and fractal dimension of the moving boundary with time is known.The statistical relations of the average velocity,the fractal dimension of the moving boundary and the porosity of porous media and the dynamic vis-cosity of fluids are proposed in this paper.It is shown that the front shape of the moving boundary of fluid flow in porous media is an integrated result of the porosity of porous media and the dynamic viscosity of fluids.

  14. Lagrangian modelling of fluid sloshing in moving tanks

    OpenAIRE

    Buldakov, E.

    2014-01-01

    The paper presents general Lagrangian formulation for sloshing of inviscid fluid in 2D tanks under vertical and horizontal excitation. In the case of a rectangular tank a third-order asymptotic solution for resonant sloshing with a dominating mode is derived using the recursive technique introduced by Buldakov et al. (2006). The problem is also solved numerically using a fully nonlinear finite difference approximation. Both the Lagrangian recursive asymptotic model and the Lagrangian fully no...

  15. Unsteady Boundary-Layer Flow over Jerked Plate Moving in a Free Stream of Viscoelastic Fluid

    Directory of Open Access Journals (Sweden)

    Sufian Munawar

    2014-01-01

    Full Text Available This study aims to investigate the unsteady boundary-layer flow of a viscoelastic non-Newtonian fluid over a flat surface. The plate is suddenly jerked to move with uniform velocity in a uniform stream of non-Newtonian fluid. Purely analytic solution to governing nonlinear equation is obtained. The solution is highly accurate and valid for all values of the dimensionless time 0≤τ<∞. Flow properties of the viscoelastic fluid are discussed through graphs.

  16. A mathematics model investigation of ideal fluids in a pipeline of moving ending

    Institute of Scientific and Technical Information of China (English)

    CHEN Bin; YI Meng-lin

    2007-01-01

    A case of ideal fluid flow in a moving ending rigid constant diameter circular pipeline is investigated.A model of the pipeline was established based on distributed-parameter theory. The comparisons on a quotient module of output and input pressure of the moving ending model and neglected ending moving model are made on the frequency response. It is revealed that the moving ending of pipeline influences largely the quotient amplitude of output and input pressure, and the peak value of frequency resonance increases with the increase of pipeline's length.

  17. Radioimmunoassay of penicilloyl groups in biological fluids

    International Nuclear Information System (INIS)

    Penicilloyl-protein conjugates may be formed in man or animals after therapeutic treatment but cannot be detected by the classical microbiological assay methods used for penicillin. Allergies have been noted in consumers of products coming from animals treated with penicillin (milk particularly). Although these compounds present a risk to public health, they passed unnoticed through hygienic food inspection. Therefore a specific and sensitive method was devised for the assay of these derivatives in biological fluids where they can be present in trace amounts. An iodine-125 labelled conjugate has been prepared. Already usable for the detection of antipenicilloyl antibodies in sera of penicillin allergic patients, it has been used for the development of a radioimmunoassay of penicilloyl groups. Assay is done directly on milk, urine and serum without previous extraction and with a detection limit of a few ppb. It permits a rapid, specific and easy to handle determination in the sera of hospital patients as well as in the inspection of animal products at the slaughter house and at the dairy

  18. Moving forward responsibly: Oversight for the nanotechnology-biology interface

    International Nuclear Information System (INIS)

    Challenges and opportunities for appropriate oversight of nanotechnology applied to or derived from biological systems (nano-bio interface) were discussed in a public workshop and dialog hosted by the Center for Science, Technology, and Public Policy of the University of Minnesota on September 15, 2005. This paper discusses the themes that emerged from the workshop, including the importance of analyzing potential gaps in current regulatory systems; deciding upon the general approach taken toward regulation; employing non-regulatory mechanisms for governance; making risk and other studies transparent and available to the public; bolstering mechanisms for public participation in risk analysis; creating more opportunities for meaningful discussion of the social and ethical dimensions of the nano-bio interface; increasing funds for implications and problem-solving research in this area; and having independent and reliable sources for communication. The workshop was successful in identifying ways of moving forward responsibly so that ultimately nanotechnology and its products can succeed in developers', researchers', regulators', and the public's eyes

  19. Numerical Study of Thermal Boundary Layer on a Continuous Moving Surface in Power Law Fluids

    Institute of Scientific and Technical Information of China (English)

    Hao ZHANG; Xinxin ZHANG; Liancun ZHENG

    2007-01-01

    This paper investigates flow and heat transfer of power law fluids on a continuous moving surface. The temperature distribution is obtained numerically by considering the effect of the power law viscosity on thermal diffusivity and the characteristics of the flow and heat transfer are analyzed. The results show that the distribution of the thermal boundary layer depends not only on the velocity ratio parameter of the plate, but also on the power law index and Prandtl number of fluids.

  20. Biological Phosphorus Removal in a Moving Bed Biofilm Reactor

    OpenAIRE

    Helness, Herman

    2007-01-01

    Phosphorus (P) and nitrogen (N) removal from municipal wastewater is performed to prevent or reduce eutrophication in the receiving water.Both P and N can be removed physical/chemically as well as biologically. While biological processes have always dominated in N-removal, chemical P-removal is used in many cases. Biological P-removal using enhanced biological phosphorus removal (EBPR) is normally carried out in suspended culture (activated sludge) processes while biological N-removal (throug...

  1. On the identifiability of a rigid body moving in a stationary viscous fluid

    International Nuclear Information System (INIS)

    This paper is devoted to a geometrical inverse problem associated with a fluid–structure system. More precisely, we consider the interaction between a moving rigid body and a viscous and incompressible fluid. Assuming a low Reynolds regime, the inertial forces can be neglected and, therefore, the fluid motion is modelled by the Stokes system. We first prove the well posedness of the corresponding system. Then we show an identifiability result: with one measure of the Cauchy forces of the fluid on one given part of the boundary and at some positive time, the shape of a convex body and its initial position are identified. (paper)

  2. A rapid and simple cannulation technique for repeated sampling of cerebrospinal fluid in freely moving rats

    NARCIS (Netherlands)

    Bouman, H.J.; Wimersma Greidanus, T.B. van

    1979-01-01

    A cannulation technique for frequent sampling of cerebrospinal fluid (CSF) in unanaesthetized freely moving rats is described. A permanent stainless steel cannula, constructed in such a way that no loss of CSF occurs, is placed into the rat's cisterna magna and fixed to the skull by anchoring screws

  3. Researchers move closer to understanding chaotic motion of a solid body in a fluid

    OpenAIRE

    Nystrom, Lynn A.

    2010-01-01

    In a paper appearing in the Feb. 24 issue of the "Proceedings of the Royal Society of London A," Virginia Tech Engineering Science and Mechanics Professor Hassan Aref, and his colleague Johan Roenby at the Technical University of Denmark shed new light on the chaotic motion of a solid body moving through a fluid.

  4. Ants as Fluids: Physics-Inspired Biology

    CERN Document Server

    Streiff, Micah; Shinotsuka, Sho; Alexeev, Alex; Hu, David

    2010-01-01

    Fire ants use their claws to grip diverse surfaces, including each other. As a result of their mutual adhesion and large numbers, ant colonies flow like inanimate fluids. In this sequence of films, we demonstrate how ants behave similarly to the spreading of drops, the capillary rise of menisci, and gravity-driven flow down a wall. By emulating the flow of fluids, ant colonies can remain united under stressful conditions.

  5. High order methods for incompressible fluid flow: Application to moving boundary problems

    Energy Technology Data Exchange (ETDEWEB)

    Bjoentegaard, Tormod

    2008-04-15

    Fluid flows with moving boundaries are encountered in a large number of real life situations, with two such types being fluid-structure interaction and free-surface flows. Fluid-structure phenomena are for instance apparent in many hydrodynamic applications; wave effects on offshore structures, sloshing and fluid induced vibrations, and aeroelasticity; flutter and dynamic response. Free-surface flows can be considered as a special case of a fluid-fluid interaction where one of the fluids are practically inviscid, such as air. This type of flows arise in many disciplines such as marine hydrodynamics, chemical engineering, material processing, and geophysics. The driving forces for free-surface flows may be of large scale such as gravity or inertial forces, or forces due to surface tension which operate on a much smaller scale. Free-surface flows with surface tension as a driving mechanism include the flow of bubbles and droplets, and the evolution of capillary waves. In this work we consider incompressible fluid flow, which are governed by the incompressible Navier-Stokes equations. There are several challenges when simulating moving boundary problems numerically, and these include - Spatial discretization - Temporal discretization - Imposition of boundary conditions - Solution strategy for the linear equations. These are some of the issues which will be addressed in this introduction. We will first formulate the problem in the arbitrary Lagrangian-Eulerian framework, and introduce the weak formulation of the problem. Next, we discuss the spatial and temporal discretization before we move to the imposition of surface tension boundary conditions. In the final section we discuss the solution of the resulting linear system of equations. (Author). refs., figs., tabs

  6. Methods for analysis of fluoroquinolones in biological fluids

    Science.gov (United States)

    Methods for analysis of 10 selected fluoroquinolone antibiotics in biological fluids are reviewed. Approaches for sample preparation, detection methods, limits of detection and quantitation and recovery information are provided for both single analyte and multi-analyte fluoroquinolone methods....

  7. THE WAVE-MAKING CHARACTERISTICS OF A MOVING BODY IN A TWO-LAYER FLUID

    Institute of Scientific and Technical Information of China (English)

    ZHU Wei

    2005-01-01

    The Wave-making characteristics of a moving body in a two-layer fluid with free surface is investigated numerically and experimentally. The numerical analysis is based on the modified layered boundary integral equation system. The wave characteristics on the free surface and interface generated by a moving sphere and an ellipsoid is numerically simulated in both finite depth and infinite depth of lower layer model. The numerical results of the sphere are compared with the analytical results for a dipole with the same velocity in a two-layer fluid of finite depth. The dependence of the wave systems and structures on the characteristic quantities is discussed. Three kinds of measurement techniques are used in model experiments on the internal waves generated by a sphere advancing in a two-layer fluid. The effects of the varying velocity and stratification on the wavelength, wave amplitudes and the maximum half angles of internal waves are analyzed qualitatively.

  8. Flat Solitary Waves due to a Submerged Body Moving in a Stratified Fluid

    Institute of Scientific and Technical Information of China (English)

    WEI Gang; SU Xiao-Bing; LU Dong-Qiang; YOU Yun-Xiang; DAI Shi-Qiang

    2008-01-01

    A theoretical model for interaction of a submerged moving body with the conjugate flow in a three-layer fluid is proposed to depict the internal flat solitary wave, which is observed in experiments conducted by the present authors. A set of coupled nonlinear algebraic equations is derived for the interracial displacements. The numerical results indicate that (a) the conjugate flow due to a two-dimensional body moving at the bottom possesses an apparent behaviour with two convex interfaces; (b) the solution satisfying the existence criterion is always unique near the relatively stable state of system. Theoretical analysis is qualitatively consistent with the experimental results obtained.

  9. Transverse vibration of an axially moving slender fiber of viscoelastic fluid in bubbfil spinning and stuffer box crimping

    OpenAIRE

    Huang Jian-Xin; Song Min-Feng; Li Zhang; Liu Peng; Chen Rou-Xi; He Ji-Huan; Wang Shu-Qiang

    2015-01-01

    Transverse vibration of an axially moving slender fiber of viscoelastic fluid is studied. The governing equations are derived under the assumptions of onedimensional steady and incompressible flow and linear Euler-Bernoulli bar. Effect of the moving velocity of the liquid fiber on natural frequencies is discussed, and the critical velocities of moving fibers are derived, below which transverse vibration is exponentially damped.

  10. Wave drag of rapidly and horizontally moving Rankine ovoid in uniformly stratified fluid

    Institute of Scientific and Technical Information of China (English)

    Zhaoting Xu; Qun Li; V. A. Gorodtsov

    2008-01-01

    A theory on the wave drag as the Rankine ovoids moving horizontally, uniformly and rapidly in uniformly vertical stratified fluid (or ocean) is presented. A mass source resulting from the theory in a uniform fluid is used to model a hydrodynamic interaction between the Rankine ovoid and stratification. Theoretical results show that there exists an asymptotic state of the drag in supercritical regimes where internal Froude numbers are large. When the Rankine ovoid reduces to a sphere, the result we obtained is in good agreement with the previous theoretical and experimental results. An experiment on the elongated Rankine ovoid is also carried out to validate the theoretical results.

  11. Volume-averaged macroscopic equation for fluid flow in moving porous media

    CERN Document Server

    Wang, Liang; Guo, Zhaoli; Mi, Jianchun

    2014-01-01

    Darcy's law and the Brinkman equation are two main models used for creeping fluid flows inside moving permeable particles. For these two models, the time derivative and the nonlinear convective terms of fluid velocity are neglected in the momentum equation. In this paper, a new momentum equation including these two terms are rigorously derived from the pore-scale microscopic equations by the volume-averaging method, which can reduces to Darcy's law and the Brinkman equation under creeping flow conditions. Using the lattice Boltzmann equation method, the macroscopic equations are solved for the problem of a porous circular cylinder moving along the centerline of a channel. Galilean invariance of the equations are investigated both with the intrinsic phase averaged velocity and the phase averaged velocity. The results demonstrate that the commonly used phase averaged velocity cannot serve as the superficial velocity, while the intrinsic phase averaged velocity should be chosen for porous particulate systems.

  12. Moving finite elements: A continuously adaptive method for computational fluid dynamics

    International Nuclear Information System (INIS)

    Moving Finite Elements (MFE), a recently developed method for computational fluid dynamics, promises major advances in the ability of computers to model the complex behavior of liquids, gases, and plasmas. Applications of computational fluid dynamics occur in a wide range of scientifically and technologically important fields. Examples include meteorology, oceanography, global climate modeling, magnetic and inertial fusion energy research, semiconductor fabrication, biophysics, automobile and aircraft design, industrial fluid processing, chemical engineering, and combustion research. The improvements made possible by the new method could thus have substantial economic impact. Moving Finite Elements is a moving node adaptive grid method which has a tendency to pack the grid finely in regions where it is most needed at each time and to leave it coarse elsewhere. It does so in a manner which is simple and automatic, and does not require a large amount of human ingenuity to apply it to each particular problem. At the same time, it often allows the time step to be large enough to advance a moving shock by many shock thicknesses in a single time step, moving the grid smoothly with the solution and minimizing the number of time steps required for the whole problem. For 2D problems (two spatial variables) the grid is composed of irregularly shaped and irregularly connected triangles which are very flexible in their ability to adapt to the evolving solution. While other adaptive grid methods have been developed which share some of these desirable properties, this is the only method which combines them all. In many cases, the method can save orders of magnitude of computing time, equivalent to several generations of advancing computer hardware

  13. WAVES GENERATED BY A SUBMERGED BODY MOVING IN STRATIFIED FLUIDS AND VERTICAL STRUCTURES OF INTERNAL WAVES

    Institute of Scientific and Technical Information of China (English)

    WEI Gang

    2004-01-01

    This dissertation deals with the internal waves generated by a submerged moving body in stratified fluids by combining theoretical and experimental methods. Our purpose is to provide some scientific evidences for non-acoustic detection of underwater moving bodies based on the principles of dynamics of the internal waves. An approach to velocity potentials obtained by superposing Green's functions of sources and sinks was proposed for Kelvin waves at the free surface or interface in a two-layer fluid. The effects of interacting surface- and internal-wave modes induced by a dipole on the surface divergence field were investigated. A new theoretical model formulating the interaction of a two-dimensional submerged moving body with the conjugate flow in a three-layer fluid was established. An exact solution satisfying the two-dimensional Benjamin-Ono equation was obtained and the vertically propagating properties of the weakly nonlinear long waves were studied by means of the ray theory and WKB method. The above theoretical results are qualitatively consistent with those obtained in the experiments conducted by the author.

  14. MHD Stagnation Flow of a Newtonian Fluid towards a Uniformly Heated and Moving Vertical Plate

    Directory of Open Access Journals (Sweden)

    Mehmet Şirin Demir

    2016-01-01

    Full Text Available Stagnation flow of an electrically conducting incompressible viscous fluid towards a moving vertical plate in the presence of a constant magnetic field is investigated. By using the appropriate transformations for the velocity components and temperature, the partial differential equations governing flow and heat transfer are reduced to a set of nonlinear ordinary differential equations. These equations are solved approximately using a numerical technique for the following two problems: (i two-dimensional stagnation-point flow on a moving vertical plate, (ii axisymmetric stagnation-point flow on a moving vertical plate. The effects of non-dimensional parameters on the velocity components, wall shear stresses, temperature and heat transfer are examined carefully.

  15. Phase transitions in fluids and biological systems

    Science.gov (United States)

    Sipos, Maksim

    In this thesis, I consider systems from two seemingly different fields: fluid dynamics and microbial ecology. In these systems, the unifying features are the existences of global non-equilibrium steady states. I consider generic and statistical models for transitions between these global states, and I relate the model results with experimental data. A theme of this thesis is that these rather simple, minimal models are able to capture a lot of functional detail about complex dynamical systems. In Part I, I consider the transition between laminar and turbulent flow. I find that quantitative and qualitative features of pipe flow experiments, the superexponential lifetime and the splitting of turbulent puffs, and the growth rate of turbulent slugs, can all be explained by a coarse-grained, phenomenological model in the directed percolation universality class. To relate this critical phenomena approach closer to the fluid dynamics, I consider the transition to turbulence in the Burgers equation, a simplified model for Navier-Stokes equations. Via a transformation to a model of directed polymers in a random medium, I find that the transition to Burgers turbulence may also be in the directed percolation universality class. This evidence implies that the turbulent-to-laminar transition is statistical in nature and does not depend on details of the Navier-Stokes equations describing the fluid flow. In Part II, I consider the disparate subject of microbial ecology where the complex interactions within microbial ecosystems produce observable patterns in microbe abundance, diversity and genotype. In order to be able to study these patterns, I develop a bioinformatics pipeline to multiply align and quickly cluster large microbial metagenomics datasets. I also develop a novel metric that quantifies the degree of interactions underlying the assembly of a microbial ecosystem, particularly the transition between neutral (random) and niche (deterministic) assembly. I apply this

  16. Complex fluids in biological systems experiment, theory, and computation

    CERN Document Server

    2015-01-01

    This book serves as an introduction to the continuum mechanics and mathematical modeling of complex fluids in living systems. The form and function of living systems are intimately tied to the nature of surrounding fluid environments, which commonly exhibit nonlinear and history dependent responses to forces and displacements. With ever-increasing capabilities in the visualization and manipulation of biological systems, research on the fundamental phenomena, models, measurements, and analysis of complex fluids has taken a number of exciting directions. In this book, many of the world’s foremost experts explore key topics such as: Macro- and micro-rheological techniques for measuring the material properties of complex biofluids and the subtleties of data interpretation Experimental observations and rheology of complex biological materials, including mucus, cell membranes, the cytoskeleton, and blood The motility of microorganisms in complex fluids and the dynamics of active suspensions Challenges and solut...

  17. Moving hydrocarbons through portions of tar sands formations with a fluid

    Energy Technology Data Exchange (ETDEWEB)

    Stegemeier, George Leo; Mudunuri, Ramesh Raju; Vinegar, Harold J.; Karanikas, John Michael; Jaiswal, Namit; Mo, Weijian

    2010-05-18

    A method for treating a tar sands formation is disclosed. The method includes heating a first portion of a hydrocarbon layer in the formation from one or more heaters located in the first portion. The heat is controlled to increase a fluid injectivity of the first portion. A drive fluid and/or an oxidizing fluid is injected and/or created in the first portion to cause at least some hydrocarbons to move from a second portion of the hydrocarbon layer to a third portion of the hydrocarbon layer. The second portion is between the first portion and the third portion. The first, second, and third portions are horizontally displaced from each other. The third portion is heated from one or more heaters located in the third portion. Hydrocarbons are produced from the third portion of the formation. The hydrocarbons include at least some hydrocarbons from the second portion of the formation.

  18. A biological hierarchical model based underwater moving object detection.

    Science.gov (United States)

    Shen, Jie; Fan, Tanghuai; Tang, Min; Zhang, Qian; Sun, Zhen; Huang, Fengchen

    2014-01-01

    Underwater moving object detection is the key for many underwater computer vision tasks, such as object recognizing, locating, and tracking. Considering the super ability in visual sensing of the underwater habitats, the visual mechanism of aquatic animals is generally regarded as the cue for establishing bionic models which are more adaptive to the underwater environments. However, the low accuracy rate and the absence of the prior knowledge learning limit their adaptation in underwater applications. Aiming to solve the problems originated from the inhomogeneous lumination and the unstable background, the mechanism of the visual information sensing and processing pattern from the eye of frogs are imitated to produce a hierarchical background model for detecting underwater objects. Firstly, the image is segmented into several subblocks. The intensity information is extracted for establishing background model which could roughly identify the object and the background regions. The texture feature of each pixel in the rough object region is further analyzed to generate the object contour precisely. Experimental results demonstrate that the proposed method gives a better performance. Compared to the traditional Gaussian background model, the completeness of the object detection is 97.92% with only 0.94% of the background region that is included in the detection results. PMID:25140194

  19. A Biological Hierarchical Model Based Underwater Moving Object Detection

    Directory of Open Access Journals (Sweden)

    Jie Shen

    2014-01-01

    Full Text Available Underwater moving object detection is the key for many underwater computer vision tasks, such as object recognizing, locating, and tracking. Considering the super ability in visual sensing of the underwater habitats, the visual mechanism of aquatic animals is generally regarded as the cue for establishing bionic models which are more adaptive to the underwater environments. However, the low accuracy rate and the absence of the prior knowledge learning limit their adaptation in underwater applications. Aiming to solve the problems originated from the inhomogeneous lumination and the unstable background, the mechanism of the visual information sensing and processing pattern from the eye of frogs are imitated to produce a hierarchical background model for detecting underwater objects. Firstly, the image is segmented into several subblocks. The intensity information is extracted for establishing background model which could roughly identify the object and the background regions. The texture feature of each pixel in the rough object region is further analyzed to generate the object contour precisely. Experimental results demonstrate that the proposed method gives a better performance. Compared to the traditional Gaussian background model, the completeness of the object detection is 97.92% with only 0.94% of the background region that is included in the detection results.

  20. Amino acid analysis in biological fluids by GC-MS

    OpenAIRE

    Kaspar, Hannelore

    2009-01-01

    Amino acids are intermediates in cellular metabolism and their quantitative analysis plays an important role in disease diagnostics. A gas chromatography-mass spectrometry (GC-MS) based method was developed for the quantitative analysis of free amino acids as their propyl chloroformate derivatives in biological fluids. Derivatization with propyl chloroformate could be carried out directly in the biological samples without prior protein precipitation or solid-phase extraction of the amino acid...

  1. Boundary Layer Flow and Heat Transfer with Variable Fluid Properties on a Moving Flat Plate in a Parallel Free Stream

    Directory of Open Access Journals (Sweden)

    Norfifah Bachok

    2012-01-01

    Full Text Available The steady boundary layer flow and heat transfer of a viscous fluid on a moving flat plate in a parallel free stream with variable fluid properties are studied. Two special cases, namely, constant fluid properties and variable fluid viscosity, are considered. The transformed boundary layer equations are solved numerically by a finite-difference scheme known as Keller-box method. Numerical results for the flow and the thermal fields for both cases are obtained for various values of the free stream parameter and the Prandtl number. It is found that dual solutions exist for both cases when the fluid and the plate move in the opposite directions. Moreover, fluid with constant properties shows drag reduction characteristics compared to fluid with variable viscosity.

  2. Remarks on Hierarchic Control for a Linearized Micropolar Fluids System in Moving Domains

    Energy Technology Data Exchange (ETDEWEB)

    Jesus, Isaías Pereira de, E-mail: isaias@ufpi.edu.br [Universidade Federal do Piauí, Dpto. Matemática (Brazil)

    2015-12-15

    We study a Stackelberg strategy subject to the evolutionary linearized micropolar fluids equations in domains with moving boundaries, considering a Nash multi-objective equilibrium (non necessarily cooperative) for the “follower players” (as is called in the economy field) and an optimal problem for the leader player with approximate controllability objective. We will obtain the following main results: the existence and uniqueness of Nash equilibrium and its characterization, the approximate controllability of the linearized micropolar system with respect to the leader control and the existence and uniqueness of the Stackelberg–Nash problem, where the optimality system for the leader is given.

  3. Transverse vibration of an axially moving slender fiber of viscoelastic fluid in bubbfil spinning and stuffer box crimping

    Directory of Open Access Journals (Sweden)

    Huang Jian-Xin

    2015-01-01

    Full Text Available Transverse vibration of an axially moving slender fiber of viscoelastic fluid is studied. The governing equations are derived under the assumptions of onedimensional steady and incompressible flow and linear Euler-Bernoulli bar. Effect of the moving velocity of the liquid fiber on natural frequencies is discussed, and the critical velocities of moving fibers are derived, below which transverse vibration is exponentially damped.

  4. Fluid extraction-biological degradation of organic wastes

    International Nuclear Information System (INIS)

    The Institute of Gas Technology (IGT) Fluid Extraction-Biological Degradation (FEBD) Process extracts hydrocarbon contaminants from soil and then biologically degrades the pollutants in aerobic bioreactors. The FEBD process has the potential to be an environmentally benign means of safely and economically degrading pollutants by overcoming bioavailability limitations of the pollutants in soil. The process consists of three stages; extraction, separation, and biodegradation. Contaminants are first removed from the soil by solubilization in supercritical carbondioxide in an above-ground extraction vessel. The hydrocarbon contaminants are then collected in a separation solvent, and clean CO2 is recycled to the extraction stage. Separation solvent containing the organic wastes is sent to the biodegradation stage where the wastes are converted to CO2, water, and biomass. All stages of the FEBD process have been successfully demonstrated. The extraction stage of the FEBD process relies on the unique properties of supercritical fluids (SCF) to remove organic contaminants from soil. An SCF is a compound at conditions exceeding its critical temperature and pressure. Fluids in the supercritical range have viscosities and diffusivities between liquids and gases with densities close to those of liquids. Supercritical fluids have the solution characteristics of liquids with better mass transfer capabilities. Extraction and separation are easily controlled because changes in the pressure (density) of an SCF can be used to change the solvation ability of the fluid

  5. Fluid dynamics of moving fish in a two-dimensional multiparticle collision dynamics model.

    Science.gov (United States)

    Reid, Daniel A P; Hildenbrandt, H; Padding, J T; Hemelrijk, C K

    2012-02-01

    The fluid dynamics of animal locomotion, such as that of an undulating fish, are of great interest to both biologists and engineers. However, experimentally studying these fluid dynamics is difficult and time consuming. Model studies can be of great help because of their simpler and more detailed analysis. Their insights may guide empirical work. Particularly the recently introduced multiparticle collision dynamics method may be suitable for the study of moving organisms because it is computationally fast, simple to implement, and has a continuous representation of space. As regards the study of hydrodynamics of moving organisms, the method has only been applied at low Reynolds numbers (below 120) for soft, permeable bodies, and static fishlike shapes. In the present paper we use it to study the hydrodynamics of an undulating fish at Reynolds numbers 1100-1500, after confirming its performance for a moving insect wing at Reynolds number 75. We measure (1) drag, thrust, and lift forces, (2) swimming efficiency and spatial structure of the wake, and (3) distribution of forces along the fish body. We confirm the resemblance between the simulated undulating fish and empirical data. In contrast to theoretical predictions, our model shows that for steadily undulating fish, thrust is produced by the rear 2/3 of the body and that the slip ratio U/V (with U the forward swimming speed and V the rearward speed of the body wave) correlates negatively (instead of positively) with the actual Froude efficiency of swimming. Besides, we show that the common practice of modeling individuals while constraining their sideways acceleration causes them to resemble unconstrained fish with a higher tailbeat frequency. PMID:22463238

  6. A quadtree adaptive method for simulating fluid flows with moving interfaces

    International Nuclear Information System (INIS)

    In this paper, a computational method for solving fluid flow problems with moving interfaces is presented. Herein, adaptive quadtree grids are used coupled with the CICSAM [O. Ubbink, Numerical prediction of two fluid systems with sharp interfaces, PhD Thesis, Imperial College of Science, Technology and Medicine, London, 1997] free surface capturing volume of fluid (VoF) method and PLIC reconstruction to interpolate the volume fraction field during refinement and derefinement processes. The combination of high resolution adaptive hierarchical remeshing and CICSAM interface advection is shown to overcome the problems of interface smearing and high CPU intensivity inherent in most VoF schemes. The result is a combination of free surface tracking and free surface capturing in that the interface is effectively tracked by the adapting refinements in the quadtree grid. In this way, a sharp interface is achieved and the advantages of both free surface tracking and capturing are combined. The new method is applied to interface advection examples in translating, rotating and shearing flow fields, and the benefits of using adapting quadtree grids demonstrated

  7. Analytical Problems in Exposing Amperometric Enzyme Biosensors to Biological Fluids

    Directory of Open Access Journals (Sweden)

    Gaia Rocchitta

    2016-05-01

    Full Text Available Enzyme-based chemical biosensors are based on biological recognition. In order to operate, the enzymes must be available to catalyze a specific biochemical reaction and be stable under the normal operating conditions of the biosensor. Design of biosensors is based on knowledge about the target analyte, as well as the complexity of the matrix in which the analyte has to be quantified. This article reviews the problems resulting from the interaction of enzyme-based amperometric biosensors with complex biological matrices containing the target analyte(s. One of the most challenging disadvantages of amperometric enzyme-based biosensor detection is signal reduction from fouling agents and interference from chemicals present in the sample matrix. This article, therefore, investigates the principles of functioning of enzymatic biosensors, their analytical performance over time and the strategies used to optimize their performance. Moreover, the composition of biological fluids as a function of their interaction with biosensing will be presented.

  8. Preparative chromatography with supercritical fluids. Comparison of simulated moving bed and batch processes.

    Science.gov (United States)

    Peper, Stephanie; Johannsen, Monika; Brunner, Gerd

    2007-12-28

    Preparative chromatography is a key technology for the separation of fine chemicals in production scale. Most of the published studies are carried out using liquid solvents as mobile phase. However, the used organic solvents can often be replaced by supercritical fluids. A reduction or renouncement of organic solvents does not only correspond to the trend of the so-called green chemistry--a sustainable, environmentally friendly production of chemical products. But a changeover to chromatography with supercritical fluids can also be reasonable under economic criteria. In this contribution a comparison between the Batch-supercritical fluid chromatography (Batch-SFC) process and the simulated moving bed (SMB)-SFC process is presented. Because of the minor importance of solvent consumption and solvent recovery in SFC, the separation systems were optimized primarily in terms of their specific productivity. For three of the four investigated model systems, the specific productivity of the SMB process is significantly higher than the productivity of the Batch process. Due to the fact, that the process with the higher specific productivity is not inevitably the more economical process, supplementary the costs of the process were considered. Therefore the comparison of the two processes was done from an economic point of view considering the minimum product price that has to be realized to fulfill the defined economic aim. It was found that although the optimized specific productivities of the SMB process were significantly higher than the productivities of the Batch process, the Batch process is the more profitable process for the investigated production rate range between 0.4 and 5t/a.

  9. Infrared light scattering in biological tissues and fluids

    Science.gov (United States)

    Thomas, Gordon A.; Koo, Tae-Woong; Dasari, Ramachandra R.; Feld, Michael S.

    2001-03-01

    We have studied the elastic and Raman scattering from whole blood, blood serum and related biological fluids and tissues. The motivation of this work is to determine the composition and elastic scattering properties with a non-invasive, optical method. An example of the possible applications is the determination of the glucose concentration and its variations in a way that would be clinically effective for patients with diabetes. We have imaged the elastically scattered light and determined the scattering parameters in order to assess appropriate geometries for efficient collection of the Raman scattering. Using the Raman apectra we have determined the concentration of glucose and the other analytes under laboratory conditions.

  10. Biological and biomedical aspects of magnetic fluid technology

    Science.gov (United States)

    Roath, S.

    1993-04-01

    Magnetic fluid technology has undergone study and development in its biological and biomedical aspects, principally in image enhancement and in the use of a variety of Separation techniques in the purification of biological materials or in the identification of very small amounts of organisms, cells, or genomic material. Many of these processes are already applied to small scale laboratory processing or manufacturing. A variety of magnetic materials are used; no standard technique has yet been consolidated but efficiency of separation especially is rapidly increasing. Clinical applications may be related both to diagnosis in areas of low level infection or contamination and also in ex-vivo processing of materials such as human bone marrow or peripheral blood where specific cell populations can be extracted. This may be a valuable tool in human bone marrow processing and in the coming field of gene transfer technology, as well as in the purification of genomic material.

  11. WAVES GENERATED BY A 3D MOVING BODY IN A TWO-LAYER FLUID OF FINITE DEPTH

    Institute of Scientific and Technical Information of China (English)

    ZHU Wei; YOU Yun-xiang; MIAO Guo-ping; ZHAO Feng; ZHANG Jun

    2005-01-01

    This paper is concerned with the waves generated by a 3-D body advancing beneath the free surface with constant speed in a two-layer fluid of finite depth. By applying Green's theorem, a layered integral equation system based on the Rankine source for the perturbed velocity potential generated by the moving body was derived with the potential flow theory. A four-node isoparametric element method was used to treat with the solution of the layered integral equation system. The surface and interface waves generated by a moving ball were calculated numerically. The results were compared with the analytical results for a moving source with constant velocity.

  12. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis.

    Directory of Open Access Journals (Sweden)

    Juhyun Lee

    Full Text Available Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS and pressure gradients (∇P across the atrioventricular (AV canal. Zebrafish (Danio rerio are a genetically tractable system to investigate cardiac morphogenesis. The use of Tg(fli1a:EGFP (y1 transgenic embryos allowed for delineation and two-dimensional reconstruction of the endocardium. This time-varying wall motion was then prescribed in a two-dimensional moving domain computational fluid dynamics (CFD model, providing new insights into spatial and temporal variations in WSS and ∇P during cardiac development. The CFD simulations were validated with particle image velocimetry (PIV across the atrioventricular (AV canal, revealing an increase in both velocities and heart rates, but a decrease in the duration of atrial systole from early to later stages. At 20-30 hours post fertilization (hpf, simulation results revealed bidirectional WSS across the AV canal in the heart tube in response to peristaltic motion of the wall. At 40-50 hpf, the tube structure undergoes cardiac looping, accompanied by a nearly 3-fold increase in WSS magnitude. At 110-120 hpf, distinct AV valve, atrium, ventricle, and bulbus arteriosus form, accompanied by incremental increases in both WSS magnitude and ∇P, but a decrease in bi-directional flow. Laminar flow develops across the AV canal at 20-30 hpf, and persists at 110-120 hpf. Reynolds numbers at the AV canal increase from 0.07±0.03 at 20-30 hpf to 0.23±0.07 at 110-120 hpf (p< 0.05, n=6, whereas Womersley numbers remain relatively unchanged from 0.11 to 0.13. Our moving domain simulations highlights hemodynamic changes in relation to cardiac morphogenesis; thereby, providing a 2-D quantitative approach to complement imaging analysis.

  13. Moving domain computational fluid dynamics to interface with an embryonic model of cardiac morphogenesis.

    Science.gov (United States)

    Lee, Juhyun; Moghadam, Mahdi Esmaily; Kung, Ethan; Cao, Hung; Beebe, Tyler; Miller, Yury; Roman, Beth L; Lien, Ching-Ling; Chi, Neil C; Marsden, Alison L; Hsiai, Tzung K

    2013-01-01

    Peristaltic contraction of the embryonic heart tube produces time- and spatial-varying wall shear stress (WSS) and pressure gradients (∇P) across the atrioventricular (AV) canal. Zebrafish (Danio rerio) are a genetically tractable system to investigate cardiac morphogenesis. The use of Tg(fli1a:EGFP) (y1) transgenic embryos allowed for delineation and two-dimensional reconstruction of the endocardium. This time-varying wall motion was then prescribed in a two-dimensional moving domain computational fluid dynamics (CFD) model, providing new insights into spatial and temporal variations in WSS and ∇P during cardiac development. The CFD simulations were validated with particle image velocimetry (PIV) across the atrioventricular (AV) canal, revealing an increase in both velocities and heart rates, but a decrease in the duration of atrial systole from early to later stages. At 20-30 hours post fertilization (hpf), simulation results revealed bidirectional WSS across the AV canal in the heart tube in response to peristaltic motion of the wall. At 40-50 hpf, the tube structure undergoes cardiac looping, accompanied by a nearly 3-fold increase in WSS magnitude. At 110-120 hpf, distinct AV valve, atrium, ventricle, and bulbus arteriosus form, accompanied by incremental increases in both WSS magnitude and ∇P, but a decrease in bi-directional flow. Laminar flow develops across the AV canal at 20-30 hpf, and persists at 110-120 hpf. Reynolds numbers at the AV canal increase from 0.07±0.03 at 20-30 hpf to 0.23±0.07 at 110-120 hpf (p< 0.05, n=6), whereas Womersley numbers remain relatively unchanged from 0.11 to 0.13. Our moving domain simulations highlights hemodynamic changes in relation to cardiac morphogenesis; thereby, providing a 2-D quantitative approach to complement imaging analysis.

  14. A form of MHD universal equations of unsteady incompressible fluid flow with variable elctroconductivity on heated moving plate

    Directory of Open Access Journals (Sweden)

    Boričić Zoran

    2005-01-01

    Full Text Available This paper deals with laminar, unsteady flow of viscous, incompressible and electro conductive fluid caused by variable motion of flat plate. Fluid electro conductivity is variable. Velocity of the plate is time function. Plate moves in its own plane and in "still" fluid. Present external magnetic filed is perpendicular to the plate. Plate temperature is a function of longitudinal coordinate and time. Viscous dissipation, Joule heat, Hole and polarization effects are neglected. For obtaining of universal equations system general similarity method is used as well as impulse and energy equation of described problem.

  15. Dynamic behavior of a fluid conveying pipe subjected to a moving sprung mass - An FEM-state space approach

    International Nuclear Information System (INIS)

    In this paper, the dynamic behavior of a pipe conveying fluid, with a sprung mass moving on it is studied. The governing equation is obtained in the transverse and longitudinal directions based on the nonlinear Von-Karman sense, by which large displacements may be taken into account. The effect of rotary inertia is also considered. Using the Galerkin method with appropriate shape functions, the dynamic equations are discretized spatially. In developing the equations of motion, a nonsymmetric damping matrix emerges due to the Coriolis effect. As a result, the eigen-values (damped natural frequencies) and eigen-vectors (mode shapes) are to be obtained by the state-space method. First, only the effect of fluid flow is considered, and the results obtained show good agreement with analytical ones under different fluid velocities. After validation of the results, the effect of a moving sprung mass with damping is added to the system, and using the Newmark-β integration scheme, the response of the system is obtained for different moving load and fluid velocities. The results show that moving mass changes the dynamic properties of the system on the one hand, and acts as an external source of force in the vibration the system on the other.

  16. Dynamic behavior of a fluid conveying pipe subjected to a moving sprung mass - An FEM-state space approach

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghi, Morteza H. [Mechanical Engineering Department, University of Tabriz, Tabriz 516 66 (Iran, Islamic Republic of); Karimi-Dona, Mohammad H., E-mail: mkarimidona@yahoo.com [Mechanical Engineering Department, University of Tabriz, Tabriz 516 66 (Iran, Islamic Republic of)

    2011-04-15

    In this paper, the dynamic behavior of a pipe conveying fluid, with a sprung mass moving on it is studied. The governing equation is obtained in the transverse and longitudinal directions based on the nonlinear Von-Karman sense, by which large displacements may be taken into account. The effect of rotary inertia is also considered. Using the Galerkin method with appropriate shape functions, the dynamic equations are discretized spatially. In developing the equations of motion, a nonsymmetric damping matrix emerges due to the Coriolis effect. As a result, the eigen-values (damped natural frequencies) and eigen-vectors (mode shapes) are to be obtained by the state-space method. First, only the effect of fluid flow is considered, and the results obtained show good agreement with analytical ones under different fluid velocities. After validation of the results, the effect of a moving sprung mass with damping is added to the system, and using the Newmark-{beta} integration scheme, the response of the system is obtained for different moving load and fluid velocities. The results show that moving mass changes the dynamic properties of the system on the one hand, and acts as an external source of force in the vibration the system on the other.

  17. Newton's Investigation of the Resistance to Moving Bodies in Continuous Fluids and the Nature of "Frontier Science"

    Science.gov (United States)

    Gauld, Colin F.

    2010-01-01

    Newton's experiments into the resistance which fluids offer to moving bodies provide some insight into the way he related theory and experiment. His theory demonstrates a way of thought typical of 17th century physics and his experiments are simple enough to be replicated by present day students. Newton's investigations using pendulums were…

  18. Boundary layer flow on a moving surface in otherwise quiescent pseudo-plastic non-Newtonian fluids

    Institute of Scientific and Technical Information of China (English)

    Liancun Zheng; Liu Ting; Xinxin Zhang

    2008-01-01

    A theoretical analysis for the boundary layer flow over a continuous moving surface in an otherwise quiescent pseudo-plastic non-Newtonian fluid medium was presented. The types of potential flows necessary for similar solutions to the boundary layer equations were determined and the solutions were numerically presented for different values of power law exponent.

  19. Irreversible Aspects of Continuum Mechanics and Transfer of Physical Characteristics in Moving Fluids : Symposia

    CERN Document Server

    Sedov, L

    1968-01-01

    At its meeting on April 23, 1965 in Paris the Bureau of IUTAM decided to have a Symposium on the Irreversible Aspects of Continaum Mechanics held in June 1966 in Vienna. In addition, a Symposium on the Transfer of Physical Characteristics in Moving Fluids which, orig­ inally, had been scheduled to take place in Stockholm was rescheduled to be held in Vienna immediately following the Symposium on the Irre­ versible Aspects of Continuum Mechanics. It was felt that the subjects of the two symposia were so closely related that participants should be given an opportunity to attend both. Both decisions were unanimously approved by the members of the General Assembly of IUTAM. Prof. H. PARKUS, Vienna, was appointed Chairman of the Symposium on the Irreversible Aspects, and Prof. L. I. SEDOV, Moscow, was appointed Chairman of the Symposium on the Transfer of Physical Characteristics, with Prof. P ARKUS being re­ sponsible for the local organization of both symposia. In accordance with the policy set forth by IUTAM...

  20. Momentum and heat transfer of an upper-convected Maxwell fluid over a moving surface with convective boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, T. [Department of Mathematics, Quaid-i-Azam University 45320, Islamabad 44000 (Pakistan); Department of Mathematics, Faculty of Science, King Abdulaziz University, P. O. Box 80257, Jeddah 21589 (Saudi Arabia); Iqbal, Z., E-mail: zahidiqbal_qau@yahoo.com [Department of Mathematics, Quaid-i-Azam University 45320, Islamabad 44000 (Pakistan); Mustafa, M. [Research Centre for Modeling and Simulation, National University of Sciences and Technology, Sector H-12, Islamabad 44000 (Pakistan); Alsaedi, A. [Department of Mathematics, Faculty of Science, King Abdulaziz University, P. O. Box 80257, Jeddah 21589 (Saudi Arabia)

    2012-11-15

    Highlights: Black-Right-Pointing-Pointer Boundary layer flow of an upper-convected Maxwell (UCM) fluid over a moving surface. Black-Right-Pointing-Pointer Convective boundary conditions have been used. Black-Right-Pointing-Pointer Series solutions are obtained by homotopy analysis method (HAM). Black-Right-Pointing-Pointer Graphical results for various interesting parametric values. - Abstract: This study discusses the flow and heat transfer in an upper-convected Maxwell (UCM) fluid over a moving surface in the presence of a free stream velocity. The convective boundary conditions have been handled. Similarly transformations are invoked to convert the partial differential equations governing the steady flow of a Maxwell fluid into an ordinary differential system. This system is solved by a homotopic approach. The effects of influential parameters such as Deborah number ({beta}), Prandtl number (Pr), Eckert number (Ec), suction parameter (S) and ratio ({lambda}) have been thoroughly examined.

  1. A Protein Microarray ELISA for Screening Biological Fluids

    Energy Technology Data Exchange (ETDEWEB)

    Varnum, Susan M.; Woodbury, Ronald L.; Zangar, Richard C.

    2004-02-01

    Protein microarrays permit the simultaneous measurement of many proteins in a small sample volume and therefore provide an attractive approach for the quantitative measurement of proteins in biological fluids, including serum. This chapter describes a microarray ELISA assay. Capture antibodies are immobilized onto a glass surface, the covalently attached antibodies bind a specific antigen from a sample overlaying the array. A second, biotinylated antibody that recognizes the same antigen as the first antibody but at a different epitope is then used for detection. Detection is based upon an enzymatic signal enhancement method known as tyramide signal amplification (TSA). By coupling a microarray-ELISA format with the signal amplification of tyramide deposition, the assay sensitivity is as low as sub-pg/ml.

  2. Obstructive renal injury: from fluid mechanics to molecular cell biology

    Directory of Open Access Journals (Sweden)

    Alvaro C Ucero

    2010-04-01

    Full Text Available Alvaro C Ucero1,*, Sara Gonçalves2,*, Alberto Benito-Martin1, Beatriz Santamaría1, Adrian M Ramos1, Sergio Berzal1, Marta Ruiz-Ortega1, Jesus Egido1, Alberto Ortiz11Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain; 2Nefrologia e Transplantação Renal, Hospital de Santa Maria EPE, Lisbon, Portugal *Both authors contributed equally to the manuscriptAbstract: Urinary tract obstruction is a frequent cause of renal impairment. The physiopathology of obstructive nephropathy has long been viewed as a mere mechanical problem. However, recent advances in cell and systems biology have disclosed a complex physiopathology involving a high number of molecular mediators of injury that lead to cellular processes of apoptotic cell death, cell injury leading to inflammation and resultant fibrosis. Functional studies in animal models of ureteral obstruction using a variety of techniques that include genetically modified animals have disclosed an important role for the renin-angiotensin system, transforming growth factor-β1 (TGF-β1 and other mediators of inflammation in this process. In addition, high throughput techniques such as proteomics and transcriptomics have identified potential biomarkers that may guide clinical decision-making.Keywords: urinary tract obstruction, renal injury, fluid mechanics, molecular cell biology

  3. Fluid models and simulations of biological cell phenomena

    Science.gov (United States)

    Greenspan, H. P.

    1982-01-01

    The dynamics of coated droplets are examined within the context of biofluids. Of specific interest is the manner in which the shape of a droplet, the motion within it as well as that of aggregates of droplets can be controlled by the modulation of surface properties and the extent to which such fluid phenomena are an intrinsic part of cellular processes. From the standpoint of biology, an objective is to elucidate some of the general dynamical features that affect the disposition of an entire cell, cell colonies and tissues. Conventionally averaged field variables of continuum mechanics are used to describe the overall global effects which result from the myriad of small scale molecular interactions. An attempt is made to establish cause and effect relationships from correct dynamical laws of motion rather than by what may have been unnecessary invocation of metabolic or life processes. Several topics are discussed where there are strong analogies droplets and cells including: encapsulated droplets/cell membranes; droplet shape/cell shape; adhesion and spread of a droplet/cell motility and adhesion; and oams and multiphase flows/cell aggregates and tissues. Evidence is presented to show that certain concepts of continuum theory such as suface tension, surface free energy, contact angle, bending moments, etc. are relevant and applicable to the study of cell biology.

  4. Mixed convection boundary layer flow over a moving vertical flat plate in an external fluid flow with viscous dissipation effect.

    Directory of Open Access Journals (Sweden)

    Norfifah Bachok

    Full Text Available The steady boundary layer flow of a viscous and incompressible fluid over a moving vertical flat plate in an external moving fluid with viscous dissipation is theoretically investigated. Using appropriate similarity variables, the governing system of partial differential equations is transformed into a system of ordinary (similarity differential equations, which is then solved numerically using a Maple software. Results for the skin friction or shear stress coefficient, local Nusselt number, velocity and temperature profiles are presented for different values of the governing parameters. It is found that the set of the similarity equations has unique solutions, dual solutions or no solutions, depending on the values of the mixed convection parameter, the velocity ratio parameter and the Eckert number. The Eckert number significantly affects the surface shear stress as well as the heat transfer rate at the surface.

  5. Three-dimensional local ALE-FEM method for fluid flow in domains containing moving boundaries/objects interfaces

    Energy Technology Data Exchange (ETDEWEB)

    Carrington, David Bradley [Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Monayem, A. K. M. [Univ. of New Mexico, Albuquerque, NM (United States); Mazumder, H. [Univ. of New Mexico, Albuquerque, NM (United States); Heinrich, Juan C. [Univ. of New Mexico, Albuquerque, NM (United States)

    2015-03-05

    A three-dimensional finite element method for the numerical simulations of fluid flow in domains containing moving rigid objects or boundaries is developed. The method falls into the general category of Arbitrary Lagrangian Eulerian methods; it is based on a fixed mesh that is locally adapted in the immediate vicinity of the moving interfaces and reverts to its original shape once the moving interfaces go past the elements. The moving interfaces are defined by separate sets of marker points so that the global mesh is independent of interface movement and the possibility of mesh entanglement is eliminated. The results is a fully robust formulation capable of calculating on domains of complex geometry with moving boundaries or devises that can also have a complex geometry without danger of the mesh becoming unsuitable due to its continuous deformation thus eliminating the need for repeated re-meshing and interpolation. Moreover, the boundary conditions on the interfaces are imposed exactly. This work is intended to support the internal combustion engines simulator KIVA developed at Los Alamos National Laboratories. The model's capabilities are illustrated through application to incompressible flows in different geometrical settings that show the robustness and flexibility of the technique to perform simulations involving moving boundaries in a three-dimensional domain.

  6. Heat transfer in a couple stress fluid over a continuous moving surface with internal hat generation and convective boundary conditions

    Energy Technology Data Exchange (ETDEWEB)

    Hayat, Tasawar [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; King Saud Univ., Riyadh (Saudi Arabia). Dept. of Physics; Iqbal, Zahid [Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Mathematics; Qasim, Muhammad [COMSATS Institute of Information Technology (CIIT), Islamabad (Pakistan). Dept. of Mathematics; Aldossary, Omar M. [King Saud Univ., Riyadh (Saudi Arabia). Dept. of Physics

    2012-05-15

    This investigation reports the boundary layer flow and heat transfer characteristics in a couple stress fluid flow over a continuos moving surface with a parallel free stream. The effects of heat generation in the presence of convective boundary conditions are also investigated. Series solutions for the velocity and temperature distributions are obtained by the homotopy analysis method (HAM). Convergence of obtained series solutions are analyzed. The results are obtained and discussed through graphs for physical parameters of interest. (orig.)

  7. Unsteady Unidirectional MHD Flow of Voigt Fluids Moving between Two Parallel Surfaces for Variable Volume Flow Rates

    OpenAIRE

    Wei-Fan Chen; Hsin-Yi Lai; Cha'o-Kuang Chen

    2012-01-01

    The velocity profile and pressure gradient of an unsteady state unidirectional MHD flow of Voigt fluids moving between two parallel surfaces under magnetic field effects are solved by the Laplace transform method. The flow motion between parallel surfaces is induced by a prescribed inlet volume flow rate that varies with time. Four cases of different inlet volume flow rates are considered in this study including (1) constant acceleration piston motion, (2) suddenly started flow, (3) linear ac...

  8. Why do we have to move fluid to be able to breathe?

    Directory of Open Access Journals (Sweden)

    Martin eFronius

    2012-05-01

    Full Text Available The ability to breathe air represents a fundamental step in vertebrate evolution that was accompanied by several anatomical and physiological adaptations. The morphology of the air-blood barrier is highly conserved within air-breathing vertebrates. It is formed by three different plies, which are represented by the alveolar epithelium, the basal lamina and the endothelial layer. Besides these conserved morphological elements, another common feature of vertebrate lungs is that they contain a certain amount of fluid that covers the alveolar epithelium. The volume and composition of the alveolar fluid is regulated by transepithelial ion transport mechanisms expressed in alveolar epithelial cells. These transport mechanisms have been reviewed extensively. Therefore, the present review focuses on the properties and functional significance of the alveolar fluid. How does the fluid enter the alveoli? What is the fate of the fluid in the alveoli? What is the function of the alveolar fluid in the lungs? The review highlights the importance of the alveolar fluid, its volume and its composition. Maintenance of the fluid volume and composition within certain limits is critical to facilitate gas exchange. We propose that the alveolar fluid is an essential element of the air-blood barrier. Therefore, it is appropriate to refer to this barrier as being formed by four plies, namely (1 the thin fluid layer covering the apical membrame of the epithelial cells, (2 the epithelial cell layer, (3 the basal membrane, and (4 the endothelial cells.

  9. [Nitric Oxide in Modulation of Crystallogenic Propeties of Biological Fluid].

    Science.gov (United States)

    Martusevich, A K; Kovaleva, L K; Davyduk, A V

    2016-01-01

    The aim of this work was a comparative analysis of the influence of different NO forms on dehydration structurization of human blood serum. Blood specimens from 15 healthy people were treated by NO-containing gas flow (800 and 80 ppm) generated with the "Plazon" unit, experimental NO-generator (20, 50, 75 and 100 ppm) and by water solution of thiol-containing dinitrosyl iron complexes (3 mM/L). The influence of blood sodium on blood serum crystallization in original and NO-treated blood specimens was estimated. It was found, that the effect of NO on crystallogenic properties of blood serum depends directly on its concentration and form (free or bound), as well as on the presence of reactive oxygen species in gas flow. The most pronounced stimulating effect was observed for the bound form of NO--dinitrosyl iron complexes with glutathione ligands. Low NO concentrations modulated crystallogenic properties of blood serum and the most optimal stimulating action was demonstrated in gas flow containing 20 ppm nitric oxide. In contrast, high NO concentration (800 ppm) inhibited the crystallogenic activity of biological fluid with multiply increasing of structural elements destruction leading to the formation of an additional belt in marginal zone of dehydrated specimens.

  10. Heterodyne QELS instrument for diagnostics of biological fluids

    Science.gov (United States)

    Lebedev, Andrei D.; Ivanova, Mariya A.; Lomakin, Aleksey V.; Noskin, Valentin A.

    1997-05-01

    The instrument for the quasielastic light scattering (QELS), LCS-03 utilizes heterodyne optical scheme which permits a high resolution determination of particle size distribution. The vibration related problems, which are common for the heterodyne techniques, have been overcome by using a single glass block incorporating all the optical elements. The real-time correlation analysis of the photocurrent fluctuations is performed by a PC-embedded analog-to-digit converter card with digital signal processor (DSP) using an original algorithm. Both the technical specifications of the instrument and the software for the size distribution analysis are presented. The heterodyne technique consistently outperforms the homodyne one when the accurate characterization of the particle size distributions in heterogeneous systems is required. Diagnostic analysis of size distribution of particles in blood serum/plasma, liquor and saliva is such an application. This kind of diagnostics usually requires a simultaneous analysis of huge number of QELS data. The original statistical algorithm with graphic user interface is described. We discuss the technical specifications of instrumentation as well as methodical problems of biological fluids QELS diagnostics.

  11. Simultaneous determination of salicylic acid and salicylamide in biological fluids

    Science.gov (United States)

    Murillo Pulgarín, J. A.; Alañón Molina, A.; Sánchez-Ferrer Robles, I.

    2011-09-01

    A new methodology for the simultaneous determination of salicylic acid and salicylamide in biological fluids is proposed. The strong overlapping of the fluorescence spectra of both analytes makes impossible the conventional fluorimetric determination. For that reason, the use of fluorescence decay curves to resolve mixtures of analytes is proposed; this is a novel technique that provides the benefits in selectivity and sensitivity of the fluorescence decay curves. In order to assess the goodness of the proposed method, a prediction set of synthetic samples were analyzed obtaining recuperation percentages between 98.2 and 104.6%. Finally, a study of the detection limits was done using a new criterion resulting in values for the detection limits of 8.2 and 11.6 μg L -1 for salicylic acid and salicylamide respectively. The validity of the method was tested in human serum and human urine spiked with aliquots of the analytes. Recoveries obtained were 96.2 and 94.5% for salicylic acid and salicylamide respectively.

  12. EFFECT OF A MOVING BOUNDARY ON THE FLUID TRANSIENT FLOW IN LOW PERMEABILITY RESERVOIRS

    Institute of Scientific and Technical Information of China (English)

    LUO Wan-Jing; WANG Xiao-dong

    2012-01-01

    In a low permeability reservoir,the existence of a moving boundary is considered in the study of the transient porous flow with threshold pressure gradient.The transmission of the moving boundary directly indicates the size of the drainage area as well as the apparent influences on the pressure behavior.The nonlinear transient flow mathematical model in which the threshold pressure gradient and the moving boundary are incorporated is solved by advanced mathematical methods.This paper presents some new analytical solutions describing the pressure distribution at a constant rate and the production decline in a constant pressure production with the boundary propagation.It is shown that the greater the threshold pressure gradient,the slower the transmission of the moving boundary,the larger the pressure loss will be,and there is no radial flow in the middle and later phases of the wellface pressure for a well at a constant rate.We have the the maximum moving boundary at a specific drawdown pressure for a low permeability reservoir.The greater the threshold pressure gradient,the smaller the maximum moving boundary distance,the quieker the production decline for a well in a constant pressure production will be.The type curve charts for the modem well test analysis and the rate transient analysis with a moving boundary are obtained and the field test and the production data are interpreted as examples to illustrate how to use our new results.

  13. An assessment of the moving point method for numerical calculation of fluid-structure interaction in water hammer

    International Nuclear Information System (INIS)

    The problem of providing an accurate numerical method for modelling fluid-structure interaction in practical water hammer calculations for power station pipe networks is addressed. The application of the moving point method to a problem representative of practical water hammer is presented. A suitable model including both liquid pressure waves and pipe wall tension waves if formulated as a set of partial differential equations with algebraic equations and boundary and initial conditions. The problem is non-dimensionalized, to identify key parameters, and a suitable linearized problem is constructed by omitting small terms. The problem is transformed to characteristic variables which are shown to be simply transported along the pipe without change of value. This motivates the choice of the moving point method. In the course of the work a program WHOMP (Water Hammer On Moving Points) was developed which exploits the moving point method. It is specific to the problem of a single pipe with thin elastic walls but the boundary and initial conditions permitted are sufficiently general that any reasonable physical problem for a single pipe can be addressed. Results of WHOMP for the model problem are compared with experimental and other numerical results including superficially those from a commercially available code FLUSTRIN. Some consideration of extending the moving point method to practical pipe networks is given. This includes the incorporation of bending and torsion waves in the pipe wall and incorporation of additional physics leading to significant non-linearity. (author)

  14. Fluid dynamics of moving fish in a two-dimensional multiparticle collision dynamics model

    NARCIS (Netherlands)

    Reid, Daniel A. P.; Hildenbrandt, H.; Hemelrijk, C. K.; Padding, J.T.

    2012-01-01

    The fluid dynamics of animal locomotion, such as that of an undulating fish, are of great interest to both biologists and engineers. However, experimentally studying these fluid dynamics is difficult and time consuming. Model studies can be of great help because of their simpler and more detailed an

  15. Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids.

    Directory of Open Access Journals (Sweden)

    Louise Fornander

    Full Text Available BACKGROUNDS: Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions. METHODS: The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach. RESULTS: Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms. CONCLUSIONS: This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.

  16. Role of Moving Bed Biofilm Reactor and Sequencing Batch Reactor in Biological Degradation of Formaldehyde Wastewater

    Directory of Open Access Journals (Sweden)

    B. Ayati

    2011-10-01

    Full Text Available Nowadays formaldehyde is used as raw material in many industries. It has also disinfection applications in some public places. Due to its toxicity for microorganisms, chemical or anaerobic biological methods are applied for treating wastewater containing formaldehyde.In this research, formaldehyde removal efficiencies of aerobic biological treatment systems including moving bed biofilm (MMBR and sequencing batch reactors (SBR were investigated. During all experiments, the efficiency of SBR was more than MBBR, but the difference was not significant statistically. According to the results, the best efficiencies were obtained for influent formaldehyde COD of 200 mg/L in MBBR and SBR which were 93% and 99.4%, respectively. The systems were also capable to treat higher formaldehyde concentrations (up to 2500 mg/L with lower removal efficiency. The reaction kinetics followed the Stover-Kincannon second order model. The gram-positive and gram-negative bacillus and coccus as well as the gram-positive binary bacillus were found to be the most dominant species. The results of 13C-NMR analysis have shown that formaldehyde and urea were converted into N-{[(aminocarbonyl amino] methyl}urea and the residual formaldehyde was polymerized at room temperature.

  17. Unsteady Unidirectional MHD Flow of Voigt Fluids Moving between Two Parallel Surfaces for Variable Volume Flow Rates

    Directory of Open Access Journals (Sweden)

    Wei-Fan Chen

    2012-01-01

    Full Text Available The velocity profile and pressure gradient of an unsteady state unidirectional MHD flow of Voigt fluids moving between two parallel surfaces under magnetic field effects are solved by the Laplace transform method. The flow motion between parallel surfaces is induced by a prescribed inlet volume flow rate that varies with time. Four cases of different inlet volume flow rates are considered in this study including (1 constant acceleration piston motion, (2 suddenly started flow, (3 linear acceleration piston motion, and (4 oscillatory piston motion. The solution for each case is elaborately derived, and the results of associated velocity profile and pressure gradients are presented in analytical forms.

  18. Disregarded Effect of Biological Fluids in siRNA Delivery: Human Ascites Fluid Severely Restricts Cellular Uptake of Nanoparticles.

    Science.gov (United States)

    Dakwar, George R; Braeckmans, Kevin; Demeester, Joseph; Ceelen, Wim; De Smedt, Stefaan C; Remaut, Katrien

    2015-11-01

    Small interfering RNA (siRNA) offers a great potential for the treatment of various diseases and disorders. Nevertheless, inefficient in vivo siRNA delivery hampers its translation into the clinic. While numerous successful in vitro siRNA delivery stories exist in reduced-protein conditions, most studies so far overlook the influence of the biological fluids present in the in vivo environment. In this study, we compared the transfection efficiency of liposomal formulations in Opti-MEM (low protein content, routinely used for in vitro screening) and human undiluted ascites fluid obtained from a peritoneal carcinomatosis patient (high protein content, representing the in vivo situation). In Opti-MEM, all formulations are biologically active. In ascites fluid, however, the biological activity of all lipoplexes is lost except for lipofectamine RNAiMAX. The drop in transfection efficiency was not correlated to the physicochemical properties of the nanoparticles, such as premature siRNA release and aggregation of the nanoparticles in the human ascites fluid. Remarkably, however, all of the formulations except for lipofectamine RNAiMAX lost their ability to be taken up by cells following incubation in ascites fluid. To take into account the possible effects of a protein corona formed around the nanoparticles, we recommend always using undiluted biological fluids for the in vitro optimization of nanosized siRNA formulations next to conventional screening in low-protein content media. This should tighten the gap between in vitro and in vivo performance of nanoparticles and ensure the optimal selection of nanoparticles for further in vivo studies.

  19. Ultrasonic wave propagation in thermoviscous moving fluid confined by heating pipeline and flow measurement performance.

    Science.gov (United States)

    Chen, Yong; Huang, Yiyong; Chen, Xiaoqian

    2013-09-01

    Ultrasonic wave propagation in thermoviscous fluid with pipeline shear mean flow in the presence of a temperature gradient is investigated. On the assumption of irrotational and axisymmetric wave propagation, a mathematical formulation of the convected wave equation is proposed without simplification in the manner of Zwikker and Kosten. A method based on the Fourier-Bessel theory, which is complete and orthogonal in Lebesgue space, is introduced to convert the wave equations into homogeneous algebraic equations. Then numerical calculation of the axial wavenumber is presented. In the end, wave attenuation in laminar and turbulent flow is numerically studied. Meanwhile measurement performance of an ultrasonic flow meter is parametrically analyzed.

  20. Drag characteristics of power law fluids on an upstream moving surface

    Institute of Scientific and Technical Information of China (English)

    Liancun Zheng; Xinxin Zhang; Jicheng He

    2005-01-01

    The specific problem to be considered here concerns the boundary layer problem of a non-Newtonian fluid on a flat plate in length, whose surface has a constant velocity opposite in the direction to that of the mainstream with Uw >> U∞, or alternatively when the plate surface velocity is kept fixed but the stream speed is reduced to zero. A theoretical analysis for a boundary layer flow is made and the self-similar equation is determined. Solutions are presented numerically for special power index and the associated transfer behavior is discussed.

  1. Ultrasonic wave propagation in thermoviscous moving fluid confined by heating pipeline and flow measurement performance.

    Science.gov (United States)

    Chen, Yong; Huang, Yiyong; Chen, Xiaoqian

    2013-09-01

    Ultrasonic wave propagation in thermoviscous fluid with pipeline shear mean flow in the presence of a temperature gradient is investigated. On the assumption of irrotational and axisymmetric wave propagation, a mathematical formulation of the convected wave equation is proposed without simplification in the manner of Zwikker and Kosten. A method based on the Fourier-Bessel theory, which is complete and orthogonal in Lebesgue space, is introduced to convert the wave equations into homogeneous algebraic equations. Then numerical calculation of the axial wavenumber is presented. In the end, wave attenuation in laminar and turbulent flow is numerically studied. Meanwhile measurement performance of an ultrasonic flow meter is parametrically analyzed. PMID:23967920

  2. Stochastic moving particle semi-implicit for inviscid fluid wave simulation

    CERN Document Server

    Naa, Christian Fredy; Kazama, Masaki

    2013-01-01

    The present paper introduces stochastic velocity as improvement for moving particle semi-implicit (MPS) method. This improvement is to overcome energy loss caused by numerical dissipation in the basic MPS that brings about rapid decay of waves. Stochastic velocity is added in the explicit step of the basic MPS method. MPS with stochastic improvement is compared with the basic method in the case of linear water waves, in particular dam break problem and standing wave in a rectangular tank. Surface detection and curve fitting are used to analyze the parameters of wave on the standing wave case. The surface detection and curved fitting was efficient to determine parameters of the wave and it was found that the stochastic improvement made the waves survived longer than in the basis method.

  3. DETERMINATION OF PARTICLE DENSITY BY MERCURY POROSIMETRY FOR BIOMASS FLUID DYNAMIC STUDY IN MOVING BEDS

    Directory of Open Access Journals (Sweden)

    Juan F. Saldarriaga

    2014-06-01

    Full Text Available Determination of the particle density is required to address the hydrodynamic study of a moving bed contactor. The measurement of this parameter is complicated when particles are irregularly shaped. In this study, two different techniques were use: compaction by mechanical compression and an alternative proposal, which contemplates the potential of mercury porosimetry for determining the surface and structural properties. It was observed that the results obtained by compacting in all cases are higher than expected. However, the values obtained by mercury porosimetry are more consistent with expected values. For example in the sawdust valued at 500kg/m3, very similar to the value of the original wood (502kg/m3. Values obtained by this procedure adequately represent the relationship between mass and volume of the particle and therefore are valid for hydrodynamic characterization of the biomass.

  4. Analysis of ray stability and caustic formation in a layered moving fluid medium

    CERN Document Server

    Bergman, David R

    2015-01-01

    Caustic formation occurs within a ray skeleton as optical or acoustic fields propagate in a medium with variable refractive properties and are unphysical, their presence being an artifact of the ray approximation of the field, and methods of correcting the field near a caustic are well known. Differential geometry provides a novel approach to calculating acoustic intensity, assessing ray stability and locating caustics in acoustic ray traces when the properties of medium are completely arbitrary by identifying points on the caustic with conjugate points along various rays. The method of geodesic deviation is applied to the problem of determining ray stability and locating caustics in 2-dimensional acoustic ray traces in a layered moving medium. Specifically, a general treatment of caustic formation in sound ducts and in piecewise continuous media is presented and applied to various idealized and realistic scenarios.

  5. Assessment of the impact of moving fluids on the regional thermal field for the area of Brandenburg (North German Basin)

    Science.gov (United States)

    Noack, V.; Scheck-Wenderoth, M.; Cacace, M.; Lewerenz, B.

    2012-04-01

    We present results from numerical simulations of the 3D thermal field for the area of Brandenburg in the North German Basin. The study area encompasses a part of the basin centre in the north, whereas to the south the basin margin is enclosed. Starting with Permocarboniferous volcanic rocks the basin fill is represented by Permian to Cenozoic sediments. A thick layer of mobilized salt (Zechstein, Upper Permian) generated elevated structures such as salt pillows and diapirs. Especially where diapirs pierce their overburden, the overlying deposits are strongly influenced in their thickness and distribution. This special configuration of the Zechstein salt is relevant for the thermal calculations due to the fact that salt has a distinctly higher thermal conductivity than the surrounding sediments and is impermeable to fluid flow. Therefore, the Zechstein salt acts as a conductive chimney for heat and a hydraulic decoupling horizon between the Pre-Permian and the Mesozoic-Cenozoic strata. The latter are characterized by two further quasi-impervious sediment complexes, the Rupelian-clay and the Muschelkalk. These two divide the Post-Permian strata in three main aquifer systems: the Buntsandstein, Keuper to Pre-Rupelian and the Post-Rupelian complex. Based on results from purely conductive modelling we additionally analyse the influence of moving fluids on the shallow temperature field above the Zechstein salt. Therefore coupled fluid flow and heat transfer numerical simulations are carried out to investigate the hydrothermal field. The 3D simulations for the heat transport processes are based on the finite element method. The results indicate that the distribution of thermal conductivities in the basin fill controls the short-wavelength pattern of the temperature distribution whereas the long wavelength pattern results from interaction between the highly conductive crust and low conductive sediments. Furthermore, the results reveal that the shallow temperature field

  6. Assessment of Blood Contamination in Biological Fluids Using MALDI-TOF MS.

    Science.gov (United States)

    Laks, Katrina; Kirsipuu, Tiina; Dmitrijeva, Tuuli; Salumets, Andres; Palumaa, Peep

    2016-06-01

    Biological fluid sample collection often includes the risk of blood contamination that may alter the proteomic profile of biological fluid. In proteomics studies, exclusion of contaminated samples is usually based on visual inspection and counting of red blood cells in the sample; analysis of specific blood derived proteins is less used. To fill the gap, we developed a fast and sensitive method for ascertainment of blood contamination in crude biological fluids, based on specific blood-derived protein, hemoglobin detection by MALDI-TOF MS. The MALDI-TOF MS based method allows detection of trace hemoglobin with the detection limit of 0.12 nM. UV-spectrometry, which was used as reference method, was found to be less sensitive. The main advantages of the presented method are that it is fast, effective, sensitive, requires very small sample amount and can be applied for detection of blood contamination in various biological fluids collected for proteomics studies. Method applicability was tested on human cerebrospinal and follicular fluid, which proteomes generally do not contain hemoglobin, however, which possess high risk for blood contamination. Present method successfully detected the blood contamination in 12 % of cerebrospinal fluid and 24 % of follicular fluid samples. High percentage of contaminated samples accentuates the need for initial inspection of proteomic samples to avoid incorrect results from blood proteome overlap.

  7. Application of Moving Bed Biofilm Process for Biological Organics and Nutrients Removal from Municipal Wastewater

    OpenAIRE

    M. Kermani; B BINA; Haji Movahedian; Amin, M. M.; M. Nikaein

    2008-01-01

    In this study, experiments have been conducted to evaluate the organics and nutrients removal from synthetic wastewater by a laboratory scale moving bed biofilm process. For nutrients removal, moving bed biofilm process has been applied in series with anaerobic, anoxic and aerobic units in four separate reactors. Moving bed biofilm reactors were operated continuously at different loading rates of nitrogen and Phosphorus. During optimum conditions, close to complete nitrification with average ...

  8. Conception and realization of a new viscometer using a magnetic fluid for measuring biological fluids.

    Science.gov (United States)

    Brancher, J P; Lucius, M; Bernardin, D; Raihani, R; Stoltz, J F

    1984-01-01

    The viscometer described in this paper comprises a vertical cylinder containing the fluid to be tested and an inner, hollow cylinder floating in the fluid and filled with magnetic liquid. The magnetic liquid and inner cylinder are set in motion by applying a rotating magnetic field. Torque is balanced by the stresses in the fluid and the inertia of the rotating cylinder. The main characteristics of this new apparatus are: - possibility of applying various torques to the rotor. Measurements of angular velocity are made on the inner cylinder (in general, conventional viscometers are built on the opposite principle), - study in transient flow. Various measurements on Newtonian fluids (water, plasma, oils, etc.) and on blood suspensions have made it possible to improve the accuracy of the method. PMID:6592002

  9. Vanishing condition for the heat flux of a relativistic fluid in a moving frame

    Science.gov (United States)

    Romero-Muñoz, Martín; Dagdug, Leonardo; Chacón-Acosta, Guillermo

    2014-11-01

    It has been asked if is appropriate to introduce the heat flow in the energy- momentum tensor, due to the non-mechanical nature of heat [1]. Although this could be answered by both kinetic and symmetry arguments, we address the problem by checking the validity of the second law of thermodynamics in a fluid that is boosted by a Lorentz transformation to a non comoving frame. In this contribution we found that this only can happen under certain conditions. Indeed, we found that there are a family of reference frames that satisfies these conditions, where Landau-Lifshitz frame is one of those. Additionally we relate such conditions with the null energy condition and the entropy production.

  10. SURFACE EFFECTS OF INTERNAL WAVE GENERATED BY A MOVING SOURCE IN A TWO-LAYER FLUID OF FINITE DEPTH

    Institute of Scientific and Technical Information of China (English)

    魏岗; 乐嘉春; 戴世强

    2003-01-01

    Based on the potential flow theory of water waves, the interaction mechanism between the free- surface and internal waves generated by a moving point source in the lower layer of a two- layer fluid was studied. By virtue of the method of Green' s function, the properties of the divergence field at the free surface were obtained, which plays an important role in the SAR ( Synthetic Aperture Radar) image. It is shown that the coupling interaction between the surface-wave mode and internal-wave mode must be taken into account for the cases of large density difference between two layers, the source approaching to the pynocline and the total Froude number Fr close to the critical number Fr2 . The theoretical analysis is qualitatively consistent with the experimental results presented by Ma Hui-yang.

  11. Asymptotic analysis of a newtonian fluid in a curved pipe with moving walls

    Science.gov (United States)

    Castiñeira, Gonzalo; Rodríguez, José M.

    2016-06-01

    This communication is devoted to the presentation of our recent results regarding the asymptotic analysis of a viscous flow in a tube with elastic walls. This study can be applied, for example, to the blood flow in an artery. With this aim, we consider the dynamic problem of the incompressible flow of a viscous fluid through a curved pipe with a smooth central curve. Our analysis leads to the obtention of an one dimensional model via singular perturbation of the Navier-Stokes system as ɛ, a non dimensional parameter related to the radius of cross-section of the tube, tends to zero. We allow the radius depend on tangential direction and time, so a coupling with an elastic or viscoelastic law on the wall of the pipe is possible. To perform the asymptotic analysis, we do a change of variable to a reference domain where we assume the existence of asymptotic expansions on ɛ for both velocity and pressure which, upon substitution on Navier-Stokes equations, leads to the characterization of various terms of the expansion. This allows us to obtain an approximation of the solution of the Navier-Stokes equations.

  12. Entropy Generation Analysis of Power-Law Non-Newtonian Fluid Flow Caused by Micropatterned Moving Surface

    Directory of Open Access Journals (Sweden)

    M. H. Yazdi

    2014-01-01

    Full Text Available In the present study, the first and second law analyses of power-law non-Newtonian flow over embedded open parallel microchannels within micropatterned permeable continuous moving surface are examined at prescribed surface temperature. A similarity transformation is used to reduce the governing equations to a set of nonlinear ordinary differential equations. The dimensionless entropy generation number is formulated by an integral of the local rate of entropy generation along the width of the surface based on an equal number of microchannels and no-slip gaps interspersed between those microchannels. The velocity, the temperature, the velocity gradient, and the temperature gradient adjacent to the wall are substituted into this equation resulting from the momentum and energy equations obtained numerically by Dormand-Prince pair and shooting method. Finally, the entropy generation numbers, as well as the Bejan number, are evaluated. It is noted that the presence of the shear thinning (pseudoplastic fluids creates entropy along the surface, with an opposite effect resulting from shear thickening (dilatant fluids.

  13. A Numerical Study on Water Waves Generated by A Submerged Moving Body in A Two-Layer Fluid System

    Institute of Scientific and Technical Information of China (English)

    YANG Jia-Zhen; NG Chiu-On; ZHANG Dao-Hua

    2009-01-01

    This is a numerical study on the time development of surface waves generated by a submerged body moving steadily in a two-layer fluid system, in which a layer of water is underlain by a layer of viscous mud. The fully nonlinear Navier-Stokes equations are solved on FLUENT with the Volume-of-Fluid (VOF) multiphase scheme in order to simulate the free surface waves as well as the water-mud interface waves as functions of time. The numerical model is validated by mimick-ing a reported experiment in a one-layer system before it is applied to a two-layer system, it is found that the presence of bottom mud in a water layer can lead to large viscous damping of the surface waves. For the investigation of the problem systematically, the effects of the Froude number and the mud layer thickness, density and viscosity relative to those of water are evaluated and discussed in detail.

  14. Presence of hepcidin-25 in biological fluids: Bile,ascitic and pleural fluids

    Institute of Scientific and Technical Information of China (English)

    Jayantha; Arnold; Arvind; Sangwaiya; Vijay; Manglam; Frank; Geoghegan; Mark; Thursz; Mark; Busbridge

    2010-01-01

    AIM: To examine body fluids such as ascitic fluid (AF),saliva,bile and pleural effusions for the presence of hepcidin using a novel radioimmunoassay (RIA).METHODS: Serum samples were collected from 25 healthy volunteers (mean age: 36 ± 11.9 years,11 males,14 females).In addition bile was obtained from 12 patients undergoing endoscopic retrograde cholangiopancreatography (mean age: 66.9 ± 16.7 years,M:F = 5:7).Saliva was collected from 17 healthy volunteers (mean age: 35 ± 9.9 years,M:F = 8:9).Pleural and AF...

  15. Cystatin C and lactoferrin concentrations in biological fluids as possible prognostic factors in eye tumor development

    Directory of Open Access Journals (Sweden)

    Mariya A. Dikovskaya

    2013-08-01

    Full Text Available Objectives. To investigate the possible role of cystatin C in eye biological fluids locally and in serum and lactoferrin revealing anti-tumor activity in eye tumor development. Background. The increased number of eye tumors was registered recently not only in the countries with high insolation, but also in the northern countries including Russia (11 cases per million of population. Search for new biological markers is important for diagnosis and prognosis in eye tumors. Cystatin C, an endogenous inhibitor of cysteine proteases, plays an important protective role in several tumors. Lactoferrin was shown to express anti-tumor and antiviral activities. It was hypothesized that cystatin C and lactoferrin could serve as possible biomarkers in the diagnosis of malignant and benign eye tumors. Study design. A total of 54 patients with choroidal melanoma and benign eye tumors were examined (part of them undergoing surgical treatment. Serum, tear fluid and intraocular fluid samples obtained from the anterior chamber of eyes in patients with choroidal melanoma were studied. Methods. Cystatin C concentration in serum and eye biological fluids was measured by commercial ELISA kits for human (BioVendor, Czechia; lactoferrin concentration – by Lactoferrin-strip D 4106 ELISA test systems (Vector-BEST, Novosibirsk Region, Russia. Results. Cystatin C concentration in serum of healthy persons was significantly higher as compared to tear and intraocular fluids. In patients with choroidal melanoma, increased cystatin C concentration was similar in tear fluid of both the eyes. Lactoferrin level in tear fluid of healthy persons was significantly higher than its serum level. Significantly increased lactoferrin concentration in tear fluid was noted in patients with benign and malignant eye tumors. Conclusion. Increased level of cystatin C in tear fluid seems to be a possible diagnostic factor in the eye tumors studied. However, it does not allow us to differentiate

  16. A radioenzymatic technique for the measurement of free and conjugated 3,4-dihydroxyphenylethyleneglycol in brain tissue and biological fluids

    International Nuclear Information System (INIS)

    A simple, sensitive and specific radioenzymatic assay for the measurement of 3,4-dihydroxyphenylethyleneglycol (DOPEG) was developed. The assay is based on the conversion of the compound to its O-methylated derivative in the presence of catechol-O-methyltransferase and [3H]S-adenosyl-methionine. The tritiated 3-methoxy-4-hydroxyphenylethyleneglycol formed is selectively extracted in organic solvents and isolated by thin layer chromatography. After oxidation to vanillin the O-methylated compound is extracted and measured by liquid scintillation spectrophotometry. This assay has been applied to the measurement of free and conjugated DOPEG is a variety of biological tissues and fluids. Both free and conjugated DOPEG were readily detected in discrete rat brain areas. Substantial amounts of free and conjugated DOPEG were also measured in ventricular perfusates from freely moving rats. Finally, the presence of DOPEG was also demonstrated in human cerebrospinal fluid, plasma and urine. Only the free form of DOPEG was found in cerebrospinal fluid, whereas both unconjugated and conjugated forms were present in plasma and urine. (Auth.)

  17. Radioenzymatic technique for the measurement of free and conjugated 3,4-dihydroxyphenylethyleneglycol in brain tissue and biological fluids

    Energy Technology Data Exchange (ETDEWEB)

    Dennis, T.; Scatton, B. (Synthelabo-L.E.R.S., Bagneux (France))

    1982-11-01

    A simple, sensitive and specific radioenzymatic assay for the measurement of 3,4-dihydroxyphenylethyleneglycol (DOPEG) was developed. The assay is based on the conversion of the compound to its O-methylated derivative in the presence of catechol-O-methyltransferase and (/sup 3/H)S-adenosyl-methionine. The tritiated 3-methoxy-4-hydroxyphenylethyleneglycol formed is selectively extracted in organic solvents and isolated by thin layer chromatography. After oxidation to vanillin the O-methylated compound is extracted and measured by liquid scintillation spectrophotometry. This assay has been applied to the measurement of free and conjugated DOPEG is a variety of biological tissues and fluids. Both free and conjugated DOPEG were readily detected in discrete rat brain areas. Substantial amounts of free and conjugated DOPEG were also measured in ventricular perfusates from freely moving rats. Finally, the presence of DOPEG was also demonstrated in human cerebrospinal fluid, plasma and urine. Only the free form of DOPEG was found in cerebrospinal fluid, whereas both unconjugated and conjugated forms were present in plasma and urine.

  18. Controlling the Mobility of the Fluid Interface of Moving Gas Bubbles or Liquid Drops by Using Micellar Solutions of Surfactants

    Science.gov (United States)

    Maldarelli, Charles; Papageorgiou, Demetrios

    1998-01-01

    Microgravity processes must rely on mechanisms other than buoyancy to move bubbles or droplets from one region to another in a continuous liquid phase. One suggested method is thermocapillary migration in which a temperature gradient is applied to the continuous phase. A significant and as yet unresolved impediment to the use of thermocapillary migration to direct bubble or drop motion is that these migrations can be significantly retarded by the adsorption onto the fluid particle surface of surface active impurities unavoidably present in the continuous or (if the particle is a liquid) droplet phases. The focus of our research was to develop a theory for remobilizing fluid particle interfaces retarded by a surfactant impurity in an effort to make more viable the use of thermocapillary migrations for the management of bubbles and drops in microgravity. We postulated that a surfactant at high bulk concentration which kinetically exchanges rapidly with the surface can restore interface mobility. The scaling arguments along with a discussion of the previous literature is reviewed in the context of the scaling framework. The specific objectives of the research were twofold. The first was to prove the remobilization theory by studying a model problem. As the mechanism for remobilization is independent of the force which drives the particle, the fluid particle shape and the presence of fluid inertia, we chose the simplest model consisting of a spherical bubble rising steadily by buoyancy in creeping flow. We solved the hydrodynamic and surfactant transport equations for rapid kinetic exchange to demonstrate that as the concentration increases, the Marangoni retardation at first increases (the low k behavior) and then decreases (the high k behavior). The second objective was to develop a method to determine the kinetic rate constants of a surfactant molecule, since this information is necessary to select surfactants which will exchange rapidly enough relative to the

  19. Evaluating Biological Treatment Systems: (i) Moving Bed Biofilm Reactor versus Biological Aerated Filtration, and (ii) Sulfide-Induced corrosion in Anaerobic Digester Gas Piping

    OpenAIRE

    Asiedu, Kofi

    2001-01-01

    The research presented in this report is in two sections. Section I involved the performance of a moving bed biofilm reactor (MBBR) versus a biological aerated filtration (BAF) and Section II involved study on causes of deposition in anaerobic digester gas piping. The first section evaluated and compared the performance of a laboratory-scale MBBR and BAF for organic carbon and suspended solids removal. A kinetic study was also performed on the MBBR to evaluate the system performance. T...

  20. Teaching Fluid Mechanics for Undergraduate Students in Applied Industrial Biology: from Theory to Atypical Experiments

    CERN Document Server

    Absi, Rafik; Dufour, Florence; Huet, Denis; Bennacer, Rachid; Absi, Tahar

    2011-01-01

    EBI is a further education establishment which provides education in applied industrial biology at level of MSc engineering degree. Fluid mechanics at EBI was considered by students as difficult who seemed somewhat unmotivated. In order to motivate them, we applied a new play-based pedagogy. Students were asked to draw inspiration from everyday life situations to find applications of fluid mechanics and to do experiments to verify and validate some theoretical results obtained in course. In this paper, we present an innovative teaching/learning pedagogy which includes the concept of learning through play and its implications in fluid mechanics for engineering. Examples of atypical experiments in fluid mechanics made by students are presented. Based on teaching evaluation by students, it is possible to know how students feel the course. The effectiveness of this approach to motivate students is presented through an analysis of students' teaching assessment. Learning through play proved a great success in fluid...

  1. Method for detection of a suspect viral deoxyribonucleic acid in an acellular biological fluid

    International Nuclear Information System (INIS)

    A method for evaluating an acellular biological fluid for the presence of a suspect viral DNA, such as DNA of the Hepatitis-B virus, is described. The acellular biological fluid is treated to immobilize in denatured form the DNAs including the suspect viral DNA on a solid substrate. This substrate is contacted with a solution including radioisotopically-labelled suspect viral denatured DNA to renature the immobilized suspect viral native DNA. The solid substrate is then evaluated for radioisotopically-labelled suspect viral renatured DNA. (author)

  2. Believe it or not: Moving non-biological stimuli believed to have human origin can be represented as human movement.

    Science.gov (United States)

    Gowen, E; Bolton, E; Poliakoff, E

    2016-01-01

    Does our brain treat non-biological movements (e.g. moving abstract shapes or robots) in the same way as human movements? The current work tested whether the movement of a non-biological rectangular object, believed to be based on a human action is represented within the observer's motor system. A novel visuomotor priming task was designed to pit true imitative compatibility, due to human action representation against more general stimulus response compatibility that has confounded previous belief experiments. Stimulus response compatibility effects were found for the object. However, imitative compatibility was found when participants repeated the object task with the belief that the object was based on a human finger movement, and when they performed the task viewing a real human hand. These results provide the first demonstration that non-biological stimuli can be represented as a human movement if they are believed to have human agency and have implications for interactions with technology and robots.

  3. Application of Moving Bed Biofilm Process for Biological Organics and Nutrients Removal from Municipal Wastewater

    Directory of Open Access Journals (Sweden)

    M. Kermani

    2008-01-01

    Full Text Available In this study, experiments have been conducted to evaluate the organics and nutrients removal from synthetic wastewater by a laboratory scale moving bed biofilm process. For nutrients removal, moving bed biofilm process has been applied in series with anaerobic, anoxic and aerobic units in four separate reactors. Moving bed biofilm reactors were operated continuously at different loading rates of nitrogen and Phosphorus. During optimum conditions, close to complete nitrification with average ammonium removal efficiency of 99.72% occurred in the aerobic reactor. In the aerobic reactor, the average specific nitrification rate was 1.8 g NOx-N kg VSS-1 h-1. The results of the average effluent soluble COD concentration from each reactor showed that denitrification process in the second anoxic reactor consumed most of the biodegradable organic matter. As seen from the results, denitrification rate has increased with increasing NOx-N loading in the second anoxic reactor. The aerobic phosphate removal rate showed a good correlation to the anaerobic phosphate release rate. Moreover, phosphate removal rate showed a strong correlation to the phosphate loading rate in the aerobic reactor. In optimum conditions, the average SCOD, total nitrogen and phosphorus removal efficiencies were 96.9, 84.6 and 95.8%, respectively. This study showed that the moving bed biofilm process could be used as an ideal and efficient option for the total nutrient removal from municipal wastewater.

  4. Drag Force of Non-newtonian Fluid on a Continuous Moving Surface with Strong Suction/Blowing

    Institute of Scientific and Technical Information of China (English)

    郑连存; 张欣欣; 赫冀成

    2003-01-01

    A theoretical analysis for the laminar boundary layer flow of a non-Newtonian fluid on a continuous moving flat plate with surface strong suction/blowing is made. The types of potential flows necessary for similar solutions to the boundary layer are determined and both analytical and numerical solutions are presented. It is shown that the solution of the boundary layer problem depends not only on the ratio of the velocity of the plate to the velocity of the free stream, but also on the suction/blowing parameter. The skin friction decreases with increasing the parameters of power law and blowing. In the case of existing suction, the shear force decreases with the increases of tangential velocity, the largest shear force occurs at wall and the smallest shear force occurs at the edge of the boundary layer. However, in the case of existing surface blowing, the shear force initially increases with tangentialvelocity and the biggest shear force occurs at the interior of the boundary layer, the skin friction approaches to zero as the blowing rate approaches the critical value.

  5. Experimental study of quasi-2D dipolar vortex streets generated by a moving momentum source in a stratified fluid

    Science.gov (United States)

    Chen, K.; You, Y.; Noblesse, F.

    2016-07-01

    Experiments are conducted in a linear stratified fluid with a momentum source modeled via a nozzle jet moving horizontally. The generation mechanism of the quasi-two-dimensional dipolar vortex streets is investigated and their evolution characteristics are analyzed. Observation shows that the formation of a dipolar vortex street requires a nonzero motion of the nozzle in addition to conditions of the Reynolds and Froude number (Re, Fr). The (Re, Fr) condition that the dipolar vortex streets can be generated is determined via experimental measurements. The explanation for the absence of such a vortex street can be the low energy of the jet and the strong body-effect disturbance of the solid nozzle. The dependence of the vortex street dimensionless formation time τ and the Strouhal number St on the Froude number Fr or the Reynolds number Re is analyzed. This analysis shows that τ and St appear to be independent of Re and approximately have power-law relations with Fr via data fitting. The exponents of Fr in the two power-law functions are -0.27 for τ and -0.21 for St, while the constant coefficients are 65 and 0.21.

  6. Transformation of vortex structures in the wake of a sphere moving in the stratified fluid with decreasing of internal Froude number

    International Nuclear Information System (INIS)

    The 3D separated, density stratified viscous fluid flows around a sphere are investigated by means of the direct numerical simulation (DNS) on the basis of the Navier-Stokes equations in the Boussinesq approximation on the supercomputers at the wide range of internal Froude (Fr) and Reynolds (Re) numbers. For DNS the Splitting on physical factors Method for Incompressible Fluid flows (SMIF) with the hybrid explicit finite difference scheme (second-order accuracy in space, minimum scheme viscosity and dispersion, monotonous) has been used. At Fr > 10 with increasing of Re we observed the flow regimes of the homogeneous viscous fluid (including the laminar-turbulent transition in the boundary layer on the sphere). With decreasing of Fr at Re < 500 the strong transformation of vortex structures in the sphere wake is demonstrated by means of the β – visualization. Thus the refined classification of the flow regimes around a sphere moving in the viscous stratified fluid is presented.

  7. Pattern formation in biological fluids II: cell deformation in shear fields evidences convective membrane organisation

    CERN Document Server

    Lofthouse, J

    2004-01-01

    The mechanical behaviour and symmetry-breaking shape deformation of red blood cells subjected to shear flows is used to demonstrate that far from being random fluids, both the membrane and cytoplasm of every biological cell undergo spatially organised convective and shear driven flows when the cell maintains a Near Equilibrium state through continuousmetabolic activity. The model demonstrates that fluid bifurcation events drive cell shape changes, rather than a Meccano like cytoskeletal structure, and represents a significant Gestalt shift in models of cell mechanics.

  8. Moving Away from Dogmatic Knowledge Dissemination in a Cell Biology Module: Examples from Singapore

    Science.gov (United States)

    Yeong, Foong May

    2012-01-01

    A surge in the amount of information in the discipline of Cell Biology presents a problem to the teaching of undergraduates under time constraints. In most textbooks and during lectures, students in Singapore are often taught in a dogmatic manner where concepts and ideas are expounded to them. The students in turn passively receive the materials…

  9. Systems Biology of cancer: Moving toward the Integrative Study of the metabolic alterations in cancer cells.

    Directory of Open Access Journals (Sweden)

    Claudia Erika Hernández Patiño

    2013-01-01

    Full Text Available One of the main objectives in systems biology is to understand the biological mechanisms that give rise to the phenotype of a microorganism by using high-throughput technologies and genome-scale mathematical modeling. The computational modeling of genome-scale metabolic reconstructions is one systemic and quantitative strategy for characterizing the metabolic phenotype associated with human diseases and potentially for designing drugs with optimal clinical effects. The purpose of this short review is to describe how computational modeling, including the specific case of constraint-based modeling, can be used to explore, characterize and predict the metabolic capacities that distinguish the metabolic phenotype of cancer cell lines. As we show herein, this computational framework is far from a pure theoretical description, and to ensure proper biological interpretation, it is necessary to integrate high-throughput data and generate predictions for later experimental assessment. Hence, genome-scale modeling serves as a platform for the following: 1 the integration of data from high-throughput technologies, 2 the assessment of how metabolic activity is related to phenotype in cancer cell lines and 3 the design of new experiments to evaluate the outcomes of the in silico analysis. By combining the functions described above, we show that computational modeling is a useful methodology to construct an integrative, systemic and quantitative scheme for understanding the metabolic profiles of cancer cell lines, a first step to determine the metabolic mechanism by which cancer cells maintain and support their malignant phenotype in human tissues.

  10. Systems biology of cancer: moving toward the integrative study of the metabolic alterations in cancer cells.

    Science.gov (United States)

    Hernández Patiño, Claudia E; Jaime-Muñoz, Gustavo; Resendis-Antonio, Osbaldo

    2012-01-01

    One of the main objectives in systems biology is to understand the biological mechanisms that give rise to the phenotype of a microorganism by using high-throughput technologies (HTs) and genome-scale mathematical modeling. The computational modeling of genome-scale metabolic reconstructions is one systemic and quantitative strategy for characterizing the metabolic phenotype associated with human diseases and potentially for designing drugs with optimal clinical effects. The purpose of this short review is to describe how computational modeling, including the specific case of constraint-based modeling, can be used to explore, characterize, and predict the metabolic capacities that distinguish the metabolic phenotype of cancer cell lines. As we show herein, this computational framework is far from a pure theoretical description, and to ensure proper biological interpretation, it is necessary to integrate high-throughput data and generate predictions for later experimental assessment. Hence, genome-scale modeling serves as a platform for the following: (1) the integration of data from HTs, (2) the assessment of how metabolic activity is related to phenotype in cancer cell lines, and (3) the design of new experiments to evaluate the outcomes of the in silico analysis. By combining the functions described above, we show that computational modeling is a useful methodology to construct an integrative, systemic, and quantitative scheme for understanding the metabolic profiles of cancer cell lines, a first step to determine the metabolic mechanism by which cancer cells maintain and support their malignant phenotype in human tissues.

  11. Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Marta Maria Duarte Carvalho Vila

    2007-04-01

    Full Text Available Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.

  12. Direct Deposition of Gas Phase Generated Aerosol Gold Nanoparticles into Biological Fluids - Corona Formation and Particle Size Shifts

    Science.gov (United States)

    Svensson, Christian R.; Messing, Maria E.; Lundqvist, Martin; Schollin, Alexander; Deppert, Knut; Pagels, Joakim H.; Rissler, Jenny; Cedervall, Tommy

    2013-01-01

    An ongoing discussion whether traditional toxicological methods are sufficient to evaluate the risks associated with nanoparticle inhalation has led to the emergence of Air-Liquid interface toxicology. As a step in this process, this study explores the evolution of particle characteristics as they move from the airborne state into physiological solution. Airborne gold nanoparticles (AuNP) are generated using an evaporation-condensation technique. Spherical and agglomerate AuNPs are deposited into physiological solutions of increasing biological complexity. The AuNP size is characterized in air as mobility diameter and in liquid as hydrodynamic diameter. AuNP:Protein aggregation in physiological solutions is determined using dynamic light scattering, particle tracking analysis, and UV absorption spectroscopy. AuNPs deposited into homocysteine buffer form large gold-aggregates. Spherical AuNPs deposited in solutions of albumin were trapped at the Air-Liquid interface but was readily suspended in the solutions with a size close to that of the airborne particles, indicating that AuNP:Protein complex formation is promoted. Deposition into serum and lung fluid resulted in larger complexes, reflecting the formation of a more complex protein corona. UV absorption spectroscopy indicated no further aggregation of the AuNPs after deposition in solution. The corona of the deposited AuNPs shows differences compared to AuNPs generated in suspension. Deposition of AuNPs from the aerosol phase into biological fluids offers a method to study the protein corona formed, upon inhalation and deposition in the lungs in a more realistic way compared to particle liquid suspensions. This is important since the protein corona together with key particle properties (e.g. size, shape and surface reactivity) to a large extent may determine the nanoparticle effects and possible translocation to other organs. PMID:24086363

  13. An expanded role for microbial physiology in metabolic engineering and functional genomics: moving towards systems biology

    DEFF Research Database (Denmark)

    Nielsen, Jens; Olsson, Lisbeth

    2002-01-01

    . With the progress in molecular biology it has become possible to optimize industrial fermentations through introduction of directed genetic modification - an approach referred to as metabolic engineering. Furthermore, as a consequence of large sequencing programs the complete genomic sequence has become available......Microbial physiology has traditionally played a very important role in both fundamental research and in industrial applications of microorganisms. The classical approach in microbial physiology has been to analyze the role of individual components (genes or proteins) in the overall cell function...

  14. Treatment of waste metalworking fluid by a hybrid ozone-biological process.

    Science.gov (United States)

    Jagadevan, Sheeja; Graham, Nigel J; Thompson, Ian P

    2013-01-15

    In metal machining processes, the regulation of heat generation and lubrication at the contact point are achieved by application of a fluid referred to as metalworking fluid (MWF). MWFs inevitably become operationally exhausted with age and intensive use, which leads to compromised properties, thereby necessitating their safe disposal. Disposal of this waste through a biological route is an increasingly attractive option, since it is effective with relatively low energy demands. However, successful biological treatment is challenging since MWFs are chemically complex, and include biocides specifically to retard microbial deterioration whilst the fluids are operational. In this study remediation of the recalcitrant component of a semi-synthetic MWF by a novel hybrid ozone-bacteriological treatment, was investigated. The hybrid treatment proved to be effective and reduced the chemical oxygen demand by 72% (26.9% and 44.9% reduction after ozonation and biological oxidation respectively). Furthermore, a near-complete degradation of three non-biodegradable compounds (viz. benzotriazole, monoethanolamine, triethanolamine), commonly added as biocides and corrosion inhibitors in MWF formulations, under ozonation was observed. PMID:23274939

  15. Hydrodynamics and convection enhanced macromolecular fluid transport in soft biological tissues: Application to solid tumor.

    Science.gov (United States)

    Dey, Bibaswan; Sekhar, G P Raja

    2016-04-21

    This work addresses a theoretical framework for transvascular exchange and extravascular transport of solute macromolecules through soft interstitial space inside a solid tumor. Most of the soft biological tissues show materialistic properties similar to deformable porous material. They exhibit mechanical behavior towards the fluid motion since the solid phase of the tumor tissue gets compressed by the drag force that is associated with the extracellular fluid flow. This paper presents a general view about the transvascular and interstitial transport of solute nutrients inside a tumor in the macroscopic level. Modified Starling׳s equation is used to describe transvascular nutrient transport. On the macroscopic level, motion of extracellular fluid within the tumor interstitium is modeled with the help of biphasic mixture theory and a spherical symmetry solution is given as a simpler case. This present model describes the average interstitial fluid pressure (IFP), extracellular fluid velocity (EFV) and flow rate of extracellular fluid, as well as the deformation of the solid phase of the tumor tissue as an immediate cause of extracellular fluid flow. When the interstitial transport is diffusion dominated, an analytical treatment of advection-diffusion-reaction equation finds the overall nutrient distribution. We propose suitable criteria for the formation of necrosis within the tumor interstitium. This study introduces some parameters that represent the nutrient supply from tumor blood vessels into the tumor extracellular space. These transport parameters compete with the reversible nutrient metabolism of the tumor cells present in the interstitium. The present study also shows that the effectiveness factor corresponding to a first order nutrient metabolism may reach beyond unity if the strength of the distributive solute source assumes positive non-zero values. PMID:26851443

  16. Analytic Approximate Solutions for MHD Boundary-Layer Viscoelastic Fluid Flow over Continuously Moving Stretching Surface by Homotopy Analysis Method with Two Auxiliary Parameters

    Directory of Open Access Journals (Sweden)

    M. M. Rashidi

    2012-01-01

    Full Text Available In this study, a steady, incompressible, and laminar-free convective flow of a two-dimensional electrically conducting viscoelastic fluid over a moving stretching surface through a porous medium is considered. The boundary-layer equations are derived by considering Boussinesq and boundary-layer approximations. The nonlinear ordinary differential equations for the momentum and energy equations are obtained and solved analytically by using homotopy analysis method (HAM with two auxiliary parameters for two classes of visco-elastic fluid (Walters’ liquid B and second-grade fluid. It is clear that by the use of second auxiliary parameter, the straight line region in ℏ-curve increases and the convergence accelerates. This research is performed by considering two different boundary conditions: (a prescribed surface temperature (PST and (b prescribed heat flux (PHF. The effect of involved parameters on velocity and temperature is investigated.

  17. Advanced treatment of biologically pretreated coal gasification wastewater using a novel anoxic moving bed biofilm reactor (ANMBBR)-biological aerated filter (BAF) system.

    Science.gov (United States)

    Zhuang, Haifeng; Han, Hongjun; Jia, Shengyong; Zhao, Qian; Hou, Baolin

    2014-04-01

    A novel system integrating anoxic moving bed biofilm reactor (ANMBBR) and biological aerated filter (BAF) with short-cut biological nitrogen removal (SBNR) process was investigated as advanced treatment of real biologically pretreated coal gasification wastewater (CGW). The results showed the system had efficient capacity of degradation of pollutants especially nitrogen removal. The best performance was obtained at hydraulic residence times of 12h and nitrite recycling ratios of 200%. The removal efficiencies of COD, total organic carbon, NH4(+)-N, total phenols and total nitrogen (TN) were 74.6%, 70.0%, 85.0%, 92.7% and 72.3%, the corresponding effluent concentrations were 35.1, 18.0, 4.8, 2.2 and 13.6mg/L, respectively. Compared with traditional A(2)/O process, the system had high performance of NH4(+)-N and TN removal, especially under the high toxic loading. Moreover, ANMBBR played a key role in eliminating toxicity and degrading refractory compounds, which was beneficial to improve biodegradability of raw wastewater for SBNR process.

  18. Bions: a family of biomimetic mineralo-organic complexes derived from biological fluids.

    Directory of Open Access Journals (Sweden)

    Cheng-Yeu Wu

    Full Text Available Mineralo-organic nanoparticles form spontaneously in human body fluids when the concentrations of calcium and phosphate ions exceed saturation. We have shown previously that these mineralo-organic nanoparticles possess biomimetic properties and can reproduce the whole phenomenology of the so-called nanobacteria-mineralized entities initially described as the smallest microorganisms on earth. Here, we examine the possibility that various charged elements and ions may form mineral nanoparticles with similar properties in biological fluids. Remarkably, all the elements tested, including sodium, magnesium, aluminum, calcium, manganese, iron, cobalt, nickel, copper, zinc, strontium, and barium form mineralo-organic particles with bacteria-like morphologies and other complex shapes following precipitation with phosphate in body fluids. Upon formation, these mineralo-organic particles, which we term bions, invariably accumulate carbonate apatite during incubation in biological fluids; yet, the particles also incorporate additional elements and thus reflect the ionic milieu in which they form. Bions initially harbor an amorphous mineral phase that gradually converts to crystals in culture. Our results show that serum produces a dual inhibition-seeding effect on bion formation. Using a comprehensive proteomic analysis, we identify a wide range of proteins that bind to these mineral particles during incubation in medium containing serum. The two main binding proteins identified, albumin and fetuin-A, act as both inhibitors and seeders of bions in culture. Notably, bions possess several biomimetic properties, including the possibility to increase in size and number and to be sub-cultured in fresh culture medium. Based on these results, we propose that bions represent biological, mineralo-organic particles that may form in the body under both physiological and pathological homeostasis conditions. These mineralo-organic particles may be part of a

  19. Enzyme Biosensors for Biomedical Applications: Strategies for Safeguarding Analytical Performances in Biological Fluids.

    Science.gov (United States)

    Rocchitta, Gaia; Spanu, Angela; Babudieri, Sergio; Latte, Gavinella; Madeddu, Giordano; Galleri, Grazia; Nuvoli, Susanna; Bagella, Paola; Demartis, Maria Ilaria; Fiore, Vito; Manetti, Roberto; Serra, Pier Andrea

    2016-01-01

    Enzyme-based chemical biosensors are based on biological recognition. In order to operate, the enzymes must be available to catalyze a specific biochemical reaction and be stable under the normal operating conditions of the biosensor. Design of biosensors is based on knowledge about the target analyte, as well as the complexity of the matrix in which the analyte has to be quantified. This article reviews the problems resulting from the interaction of enzyme-based amperometric biosensors with complex biological matrices containing the target analyte(s). One of the most challenging disadvantages of amperometric enzyme-based biosensor detection is signal reduction from fouling agents and interference from chemicals present in the sample matrix. This article, therefore, investigates the principles of functioning of enzymatic biosensors, their analytical performance over time and the strategies used to optimize their performance. Moreover, the composition of biological fluids as a function of their interaction with biosensing will be presented. PMID:27249001

  20. Hybrid biological, electron beam and zero-valent nano iron treatment of recalcitrant metalworking fluids.

    Science.gov (United States)

    Thill, Patrick G; Ager, Duane K; Vojnovic, Borivoj; Tesh, Sarah J; Scott, Thomas B; Thompson, Ian P

    2016-04-15

    Hybrid approaches for the remediation and detoxification of toxic recalcitrant industrial wastewater were investigated. The focus was waste metalworking fluid, which was selected as a representative model of other waste streams that are toxic, recalcitrant and that require more sustainable routes of safe disposal. The hybrid approaches included biodegradation, electron beam irradiation and zero-valent nano iron advanced oxidation processes that were employed individually and in sequence employing a factorial design. To compare process performance operationally exhausted and pristine metalworking fluid were compared. Sequential hybrid electron beam irradiation, biological, nanoscale zero-valent iron and biological treatment lead to synergistic detoxification and degradation of both recalcitrant streams, as determined by complementary surrogates and lead to overall improved COD removal of 92.8 ± 1.4% up from 85.9 ± 3.4% for the pristine metalworking fluid. Electron beam pre-treatment enabled more effective biotreatment, achieving 69.5 ± 8% (p = 0.005) and 24.6 ± 4.8% (p = 0.044) COD reductions. PMID:26905800

  1. A 3D, fully Eulerian, VOF-based solver to study the interaction between two fluids and moving rigid bodies using the fictitious domain method

    Science.gov (United States)

    Pathak, Ashish; Raessi, Mehdi

    2016-04-01

    We present a three-dimensional (3D) and fully Eulerian approach to capturing the interaction between two fluids and moving rigid structures by using the fictitious domain and volume-of-fluid (VOF) methods. The solid bodies can have arbitrarily complex geometry and can pierce the fluid-fluid interface, forming contact lines. The three-phase interfaces are resolved and reconstructed by using a VOF-based methodology. Then, a consistent scheme is employed for transporting mass and momentum, allowing for simulations of three-phase flows of large density ratios. The Eulerian approach significantly simplifies numerical resolution of the kinematics of rigid bodies of complex geometry and with six degrees of freedom. The fluid-structure interaction (FSI) is computed using the fictitious domain method. The methodology was developed in a message passing interface (MPI) parallel framework accelerated with graphics processing units (GPUs). The computationally intensive solution of the pressure Poisson equation is ported to GPUs, while the remaining calculations are performed on CPUs. The performance and accuracy of the methodology are assessed using an array of test cases, focusing individually on the flow solver and the FSI in surface-piercing configurations. Finally, an application of the proposed methodology in simulations of the ocean wave energy converters is presented.

  2. Generation of stationary and moving vortices in active polar fluids in the planar Taylor-Couette geometry.

    Science.gov (United States)

    Neef, M; Kruse, K

    2014-11-01

    We study the dynamics of an active polar fluid in the interstitial space between two fixed coaxial cylinders. For sufficiently large expansive or contractive active stresses, the fluid presents roll instabilities of axially symmetric states leading to the spontaneous formation of vortices in the flow field. These vortices are either stationary or travel around the inner cylinder. Increasing the activity further, our numerical solutions indicate the existence of active turbulence that coexists with regular vortex solutions. PMID:25493812

  3. Evaluation of the solubility of the HPMC: PVA blends in biological fluids in vitro

    OpenAIRE

    Sara Elis Bianchi; Valeria Weiss Angeli; Kellen Cristhinia Borges de Souza; Diogo dos Santos Miron; Gláucio de Almeida Carvalho; Venina dos Santos; Rosmary Nichele Brandalise

    2011-01-01

    Polymers are often used to coat tablets for controlled drug release. The purpose of this study is to evaluate the solubility of the HPMC and PVA blend compared to isolated polymers in solutions with a pH of biological fluids (6 and 1.2) and the dissolution of capsules obtained using theophylline granules produced with the HPMC/PVA 25/75 blend as a matrix and as coating. HPMC is completely solubilized in the medium that simulates the pH of the stomach and intestine, and PVA is the polymer that...

  4. Quantitation of methadone in biological fluids using deuterium labeled internal standards

    International Nuclear Information System (INIS)

    Deuterium labeled methadone which contained five 2H atoms in one aromatic ring was synthesized for use as an internal standard for quantitation of methadone in biological fluids. The method can measure plasma and urine levels of methadone down to 5 ng/ml. Plasma methadone levels were measured in several patients undergoing methadone maintenance therapy. Plasma levels generally fall between 100 and 400 ng/ml at an oral dose of 1 mg/kg. The half-life of methadone is estimated at 28.8 +- 4.8 hours and the volume of distribution is 312 liters

  5. Biomineralization studies on cellulose membrane exposed to biological fluids of Anodonta cygnea.

    Science.gov (United States)

    Lopes, Anabela; Lopes-Lima, Manuel; Ferreira, Jorge; Araújo, Sandra; Hinzmann, Mariana; Oliveira, José; Rocha, António; Domingues, Bernardo; Bobos, Iulius; Machado, Jorge

    2014-06-01

    The present work proposes to analyse the results obtained under in vitro conditions where cellulose artificial membranes were incubated with biological fluids from the freshwater bivalve Anodonta cygnea. The membranes were mounted between two half 'Ussing chambers' with different composition solutions in order to simulate epithelial surfaces separating organic fluid compartments. The membrane surfaces were submitted to two synthetic calcium and phosphate solutions on opposite sides, at pH 6.0, 7.0 or 9.0 during a period of 6 hours. Additional assays were accomplished mixing these solutions with haemolymph or extrapallial fluid from A. cygnea, only on the calcium side. A selective ion movement, mainly dependent on the membrane pore size and/or cationic affinity, occurred with higher permeability for calcium ions to the opposite phosphate chamber supported by calcium diffusion forces across the cellulose membrane. In general, this promoted a more intense mineral precipitation on the phosphate membrane surface. A strong deposition of calcium phosphate mineral was observed at pH 9.0 as a primary layer with a homogeneous microstructure, being totally absent at pH 6.0. The membrane showed an additional crystal phase at pH 7.0 exhibiting a very particular hexagonal or cuttlebone shape, mainly on the phosphate surface. When organic fluids of A. cygnea were included, these crystal forms presented a high tendency to aggregate under rosaceous shapes, also predominantly in the phosphate side. The cellulose membrane was permeable to small organic molecules that diffused from the calcium towards the phosphate side. In the calcium side, very few similar crystals were observed. The presence of organic matrix from A. cygnea fluids induced a preliminary apatite-brushite crystal polymorphism. So, the present results suggest that cellulose membranes can be used as surrogates of biological epithelia with preferential ionic diffusion from the calcium to the phosphate side where the main

  6. DeepPIV: Measuring in situ Biological-Fluid Interactions from the Surface to Benthos

    Science.gov (United States)

    Katija, K.; Sherman, A.; Graves, D.; Kecy, C. D.; Klimov, D.; Robison, B. H.

    2015-12-01

    The midwater region of the ocean (below the euphotic zone and above the benthos) is one of the largest ecosystems on our planet, yet it remains one of the least explored. Little known marine organisms that inhabit midwater have developed strategies for swimming and feeding that ultimately contributes to their evolutionary success, and may inspire engineering solutions for societally relevant challenges. Fluid mechanics governs the interactions that midwater organisms have with their physical environment, but limited access to midwater depths and lack of non-invasive methods to measure in situ small-scale fluid motions prevent these interactions from being better understood. Significant advances in underwater vehicle technologies have only recently improved access to midwater. Unfortunately, in situ small-scale fluid mechanics measurement methods are still lacking in the oceanographic community. Here we present DeepPIV, an instrumentation package that can be affixed to remotely operated underwater vehicles that quantifies small-scale fluid motions from the surface of the ocean down to 4000 m depths. Utilizing ambient, suspended particulate in the coastal regions of Monterey Bay, fluid-structure interactions are evaluated on a range of marine organisms in midwater. Initial science targets include larvaceans, biological equivalents of flapping flexible foils, that create mucus houses to filter food. Little is known about the structure of these mucus houses and the function they play in selectively filtering particles, and these dynamics can serve as particle-mucus models for human health. Using DeepPIV, we reveal the complex structures and flows generated within larvacean mucus houses, and elucidate how these structures function.

  7. Electromembrane extraction as a rapid and selective miniaturized sample preparation technique for biological fluids

    DEFF Research Database (Denmark)

    Gjelstad, Astrid; Pedersen-Bjergaard, Stig; Seip, Knut Fredrik

    2015-01-01

    This special report discusses the sample preparation method electromembrane extraction, which was introduced in 2006 as a rapid and selective miniaturized extraction method. The extraction principle is based on isolation of charged analytes extracted from an aqueous sample, across a thin film...... of organic solvent, and into an aqueous receiver solution. The extraction is promoted by application of an electrical field, causing electrokinetic migration of the charged analytes. The method has shown to perform excellent clean-up and selectivity from complicated aqueous matrices like biological fluids....... Technical aspects of electromembrane extraction, important extraction parameters as well as a handful of examples of applications from different biological samples and bioanalytical areas are discussed in the paper....

  8. The Balance of Fluid and Osmotic Pressures across Active Biological Membranes with Application to the Corneal Endothelium.

    Directory of Open Access Journals (Sweden)

    Xi Cheng

    Full Text Available The movement of fluid and solutes across biological membranes facilitates the transport of nutrients for living organisms and maintains the fluid and osmotic pressures in biological systems. Understanding the pressure balances across membranes is crucial for studying fluid and electrolyte homeostasis in living systems, and is an area of active research. In this study, a set of enhanced Kedem-Katchalsky (KK equations is proposed to describe fluxes of water and solutes across biological membranes, and is applied to analyze the relationship between fluid and osmotic pressures, accounting for active transport mechanisms that propel substances against their concentration gradients and for fixed charges that alter ionic distributions in separated environments. The equilibrium analysis demonstrates that the proposed theory recovers the Donnan osmotic pressure and can predict the correct fluid pressure difference across membranes, a result which cannot be achieved by existing KK theories due to the neglect of fixed charges. The steady-state analysis on active membranes suggests a new pressure mechanism which balances the fluid pressure together with the osmotic pressure. The source of this pressure arises from active ionic fluxes and from interactions between solvent and solutes in membrane transport. We apply the proposed theory to study the transendothelial fluid pressure in the in vivo cornea, which is a crucial factor maintaining the hydration and transparency of the tissue. The results show the importance of the proposed pressure mechanism in mediating stromal fluid pressure and provide a new interpretation of the pressure modulation mechanism in the in vivo cornea.

  9. The Content and Size of Hyaluronan in Biological Fluids and Tissues

    Directory of Open Access Journals (Sweden)

    Mary K. Cowman

    2015-06-01

    Full Text Available Hyaluronan is a simple repeating disaccharide polymer, synthesized at the cell surface by integral membrane synthases. The repeating sequence is perfectly homogeneous, and is the same in all vertebrate tissues and fluids. The polymer molecular mass is more variable. Most commonly, hyaluronan is synthesized as a high molecular mass polymer, with an average molecular mass of approximately 1000-8000 kDa. There are a number of studies showing increased hyaluronan content, but reduced average molecular mass with a broader range of sizes present, in tissues or fluids when inflammatory or tissue remodeling processes occur. In parallel studies, exogenous hyaluronan fragments of low molecular mass (generally, less than about 200 kDa have been shown to affect cell behavior through binding to receptor proteins such as CD44 and RHAMM (gene name HMMR, and to signal either directly or indirectly through Toll-like receptors. These data suggest that receptor sensitivity to hyaluronan size provides a biosensor of the state of the microenvironment surrounding the cell. Sensitive methods for isolation and characterization of hyaluronan and its fragments have been developed and continue to improve. This review provides an overview of the methods and our current state of knowledge of hyaluronan content and size distribution in biological fluids and tissues.

  10. Biological removal of phenol from saline wastewater using a moving bed biofilm reactor containing acclimated mixed consortia.

    Science.gov (United States)

    Nakhli, Seyyed Ali Akbar; Ahmadizadeh, Kimia; Fereshtehnejad, Mahmood; Rostami, Mohammad Hossein; Safari, Mojtaba; Borghei, Seyyed Mehdi

    2014-01-01

    In this study, the performance of an aerobic moving bed biofilm reactor (MBBR) was assessed for the removal of phenol as the sole substrate from saline wastewater. The effect of several parameters namely inlet phenol concentration (200-1200 mg/L), hydraulic retention time (8-24 h), inlet salt content (10-70 g/L), phenol shock loading, hydraulic shock loading and salt shock loading on the performance of the 10 L MBBR inoculated with a mixed culture of active biomass gradually acclimated to phenol and salt were evaluated in terms of phenol and chemical oxygen demand (COD) removal efficiencies. The results indicated that phenol and COD removal efficiencies are affected by HRT, phenol and salt concentration in the bioreactor saline feed. The MBBR could remove up to 99% of phenol and COD from the feed saline wastewater at inlet phenol concentrations up to 800 mg/L, HRT of 18 h and inlet salt contents up to 40 g/L. The reactor could also resist strong shock loads. Furthermore, measuring biological quantitative parameters indicated that the biofilm plays a main role in phenol removal. Overall, the results of this investigation revealed that the developed MBBR system with high concentration of the active mixed biomass can play a prominent role in order to treat saline wastewaters containing phenol in industrial applications as a very efficient and flexible technology.

  11. A compact process for treating oilfield wastewater by combining hydrolysis acidification, moving bed biofilm, ozonation and biologically activated carbon techniques.

    Science.gov (United States)

    Zheng, Tao

    2016-01-01

    A lab-scale hybrid system integrating a hybrid hydrolysis acidification (HA) reactor, a moving bed biofilm reactor (MBBR) and an ozonation-biologically activated carbon (O3-BAC) unit was used in the treatment of heavy oil wastewater with high chemical oxygen demand (COD) and low biodegradability. The effects of hydraulic retention time and ozonation time were investigated. The results show that under the optimal conditions, the effluent concentrations of COD, oil and ammonia were 48, 1.3 and 3.5 mg/L, respectively, corresponding to total removal efficiencies of 95.8%, 98.9% and 94.4%, respectively. The effluent could meet the grade I as required by the national discharge standard of China. The HA process remarkably improved the biodegradability of the wastewater, while the MBBR process played an important role in degrading COD. The ozonation process further enhanced the biodegradability of the MBBR effluent, and finally, deep treatment was completed in the BAC reactor. This work demonstrates that the hybrid HA/MBBR/O3-BAC system has the potential to be used for the treatment of high-strength oilfield wastewater.

  12. Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays.

    Science.gov (United States)

    Karakosta, Theano D; Soosaipillai, Antoninus; Diamandis, Eleftherios P; Batruch, Ihor; Drabovich, Andrei P

    2016-09-01

    Human kallikrein-related peptidases (KLKs) are a group of 15 secreted serine proteases encoded by the largest contiguous cluster of protease genes in the human genome. KLKs are involved in coordination of numerous physiological functions including regulation of blood pressure, neuronal plasticity, skin desquamation, and semen liquefaction, and thus represent promising diagnostic and therapeutic targets. Until now, quantification of KLKs in biological and clinical samples was accomplished by enzyme-linked immunosorbent assays (ELISA). Here, we developed multiplex targeted mass spectrometry assays for the simultaneous quantification of all 15 KLKs. Proteotypic peptides for each KLK were carefully selected based on experimental data and multiplexed in single assays. Performance of assays was evaluated using three different mass spectrometry platforms including triple quadrupole, quadrupole-ion trap, and quadrupole-orbitrap instruments. Heavy isotope-labeled synthetic peptides with a quantifying tag were used for absolute quantification of KLKs in sweat, cervico-vaginal fluid, seminal plasma, and blood serum, with limits of detection ranging from 5 to 500 ng/ml. Analytical performance of assays was evaluated by measuring endogenous KLKs in relevant biological fluids, and results were compared with selected ELISAs. The multiplex targeted proteomic assays were demonstrated to be accurate, reproducible, sensitive, and specific alternatives to antibody-based assays. Finally, KLK4, a highly prostate-specific protein and a speculated biomarker of prostate cancer, was unambiguously detected and quantified by immunoenrichment-SRM assay in seminal plasma and blood serum samples from individuals with confirmed prostate cancer and negative biopsy. Mass spectrometry revealed exclusively the presence of a secreted isoform and thus unequivocally resolved earlier disputes about KLK4 identity in seminal plasma. Measurements of KLK4 in either 41 seminal plasma or 58 blood serum samples

  13. Application of LC-MS/MS for quantitative analysis of glucocorticoids and stimulants in biological fluids

    Institute of Scientific and Technical Information of China (English)

    Jamshed Haneef; Mohammad Shaharyar; Asif Husaina; Mohd Rashid; Ravinesh Mishra; Shama Parveen; Niyaz Ahmed; Manoj Pal; Deepak Kumar

    2013-01-01

    Liquid chromatography tandem mass chromatography (LC-MS/MS) is an important hyphenated technique for quantitative analysis of drugs in biological fluids. Because of high sensitivity and selectivity, LC-MS/MS has been used for pharmacokinetic studies, metabolites identification in the plasma and urine. This manuscript gives comprehensive analytical review, focusing on chromatographic separation approaches (column packing materials, column length and mobile phase) as well as different acquisition modes (SIM, MRM) for quantitative analysis of glucocorticoids and stimulants. This review is not meant to be exhaustive but rather to provide a general overview for detection and confirmation of target drugs using LC-MS/MS and thus useful in the doping analysis, toxicological studies as well as in pharmaceutical analysis.

  14. Methotrexate concentrations in biological fluids: Comparison of results obtained by radioimmunoassay and direct ligand binding radioassay

    International Nuclear Information System (INIS)

    A sensitive (sensitivity 2.2 x 10-9 mol/l) and specific (practically no cross-reaction with circulating folates) radioimmunoassay for the determination of methotrexate concentrations in biological fluids is described and compared with a commercial competitive protein binding assay. Antiserum with high titer was produced in rabbits immunized with MTX-human serum albumin conjugate. Fitness for use in pharmacokinetic drug level determinations was shown in three patients, who received both low doses and high dose therapy combined with citrovorum factor rescue. An excellent correlation was found between plasma and urine MTX concentrations obtained by RIA and competitive protein binding assay. A two-compartment pharmacokinetic model was found adequately describing the serum decay curves, but there was a great interindividual variability in the calculated pharmacokinetic parameters. (author)

  15. Microfauna communities as performance indicators for an A/O Shortcut Biological Nitrogen Removal moving-bed biofilm reactor.

    Science.gov (United States)

    Canals, O; Salvadó, H; Auset, M; Hernández, C; Malfeito, J J

    2013-06-01

    The microfauna communities present in the mixed liquor and biofilm of an Anoxic/Oxic Shortcut Biofilm Nitrogen Removal moving-bed biofilm process were characterised in order to optimise process control through the use of bioindicators. The system operated at high ammonium concentrations, with an average of 588 ± 220 mg N-NH4(+) L(-1) in the influent, 161 ± 80 mg L(-1) in the anoxic reactor and 74 ± 71.2 mg L(-1) in the aerobic reactor. Up to 20 different taxa were identified, including ciliates (4), flagellates (11), amoebae (4) and nematodes (1). Compared to conventional wastewater treatment processes (WWTPs), this process can be defined as a flagellates-predominant system with a low diversity of ciliates. Flagellates were mainly dominant in the mixed liquor, demonstrating high tolerance to ammonium and the capacity for survival over a long time under anoxic conditions. The data obtained provide interesting values of maximum and minimum tolerance ranges to ammonium, nitrates and nitrites for the ciliate species Cyclidium glaucoma, Colpoda ecaudata, Vorticella microstoma-complex and Epistylis cf. rotans. The last of these was the only ciliate species that presented a constant and abundant population, almost exclusively in the aerobic biofilm. Epistylis cf. rotans dynamics showed a high negative correlation with ammonium variations and a positive correlation with ammonium removal efficiency. Hence, the results indicate that Epistylis cf. rotans is a good bioindicator of the nitrification process in this system. The study of protozoan communities in unexplored WWTPs sheds light on species ecology and their role under conditions that have been little studied in WWTPs, and could offer new biological management tools.

  16. Deep fluids effects on rupture of slow-moving giant landslides as a result of stress transfer and weakening

    Science.gov (United States)

    Guglielmi, Y.; Cappa, F.; Viseur, S.; Baudement, C.; Garambois, S.

    2014-12-01

    Landslides in Earth's surface accommodate slow, aseismic slip and fast, seismic rupture influenced by fluid pressures and rock frictional properties. The study of strain partitioning in two French mega-rockslides (La Clapière and Séchilienne, estimated volumes of 60 ± 10 × 106 m3, France) provides a unique insights into this influence. Here we show that, by hydromechanical modeling, a significant part of the observed rockslide motions and seismicity may be caused by poroelastic strain in the deep part of the slope, induced by groundwater table variations. In the unstable volume near surface, calculated strain and rupture are controlled by stress transfer and friction weakening above the phreatic zone and reproduce well the high-motion zone measured by geodesy and geophysics. The key model parameters are the friction weakening and the position of groundwater level that are constrained by field hydrogeochemical and geodetic data to support the physical validity of the model. These results highlighting deep fluids major control on the rupture of superficial rock slopes are of importance for giant collapse monitoring strategies and for the understanding of the near surface strain long term pluriannual evolution under weak forcing.

  17. Structuring Characteristics of Biological Fluids of Patients with Combined Cardiovascular and Gastrointestinal Pathology

    Directory of Open Access Journals (Sweden)

    Simonova Zh.G.

    2014-09-01

    Full Text Available The aim of the investigation was a comparative study of the result of self- and initiated crystallization of saliva and urine in patients with an isolated ulcer disease, coronary heart disease (CHD, and the combination of both. Materials and Methods. We studied saliva and urine samplings in 35 patients with isolated CHD, in 48 — with ulcer disease, and in 112 — with the combination of both. CHD was diagnosed based on a clinical study, as well as according to the findings of instrumental studies (ECG recording at rest and physical load, Holter ECG monitoring, echocardiography. The diagnosis of ulcer disease was verified by fibrogastroduodenoscopy; helicobacteriosis was revealed by biopsy and serologic testing. The characteristics of self- and initiated crystallization of biological substrates were assessed using a semiquantitative analysis. Normal saline was a basic substance for teziography. Results. A combined pathology was found to have a specific character in the formation of crystallogenic properties of biological fluid facies of patients. This fact is consistent with the data indicating dysmetabolic disorders, which integrate the diseases under study and are caused by Helicobacter pylori. The findings both confirm the presence of metabolic response of the body on comorbidity and also can serve as the basis for the development of noninvasive technologies to monitor the effectiveness of Helicobacter pylori eradication.

  18. Deep fluids can facilitate rupture of slow-moving giant landslides as a result of stress transfer and frictional weakening

    Science.gov (United States)

    Cappa, Frédéric; Guglielmi, Yves; Viseur, Sophie; Garambois, Stéphane

    2014-01-01

    Landslides accommodate slow, aseismic slip and fast, seismic rupture, which are sensitive to fluid pressures and rock frictional properties. The study of strain partitioning in the Séchilienne landslide (France) provides a unique insight into this sensitivity. Here we show with hydromechanical modeling that a significant part of the observed landslide motions and associated seismicity may be caused by poroelastic strain below the landslide, induced by groundwater table variations. In the unstable volume near the surface, calculated strain and rupture may be controlled by stress transfer and friction weakening above the phreatic zone and reproduce well high-motion zone characteristics measured by geodesy and geophysics. The key model parameters are friction weakening and the position of groundwater level, which is sufficiently constrained by field data to support the physical validity of the model. These results are of importance for the understanding of surface strain evolution under weak forcing.

  19. MHD Effects on Non-Newtonian Power-Law Fluid Past a Continuously Moving Porous Flat Plate with Heat Flux and Viscous Dissipation

    Science.gov (United States)

    Kishan, N.; Shashidar Reddy, B.

    2013-06-01

    The problem of a magneto-hydro dynamic flow and heat transfer to a non-Newtonian power-law fluid flow past a continuously moving flat porous plate in the presence of sucion/injection with heat flux by taking into consideration the viscous dissipation is analysed. The non-linear partial differential equations governing the flow and heat transfer are transformed into non-linear ordinary differential equations using appropriate transformations and then solved numerically by an implicit finite difference scheme. The solution is found to be dependent on various governing parameters including the magnetic field parameter M, power-law index n, suction/injection parameter ƒw, Prandtl number Pr and Eckert number Ec. A systematical study is carried out to illustrate the effects of these major parameters on the velocity profiles, temperature profile, skin friction coefficient and rate of heat transfer and the local Nusslet number.

  20. Effect of Viscous Dissipation on MHD Free Convection Flow Heat and Mass Transfer of Non-Newtonian Fluids along a Continuously Moving Stretching Sheet

    Directory of Open Access Journals (Sweden)

    K.C. Saha

    2015-04-01

    Full Text Available The effects of MHD free convection heat and mass transfer of power-law Non-Newtonian fluids along a stretching sheet with viscous dissipation has been analyzed. This has been done under the simultaneous action of suction, thermal radiation and uniform transverse magnetic field. The stretching sheet is assumed to continuously moving with a power-law velocity and maintaining a uniform surface heat-flux. The governing non-linear partial differential equations are transformed into non-linear ordinary differential equations, using appropriate similarity transformations and the resulting problem is solved numerically using Nachtsheim-Swigert shooting iteration technique along with sixth order Runge-Kutta integration scheme. A parametric study of the parameters arising in the problem such as the Eckert number due to viscous dissipation, radiation number, buoyancy parameter, Schmidt number, Prandtl number etc are studied and the obtained results are shown graphically and the physical aspects of the problem are discussed.

  1. Moving Hands, Moving Entities

    Science.gov (United States)

    Setti, Annalisa; Borghi, Anna M.; Tessari, Alessia

    2009-01-01

    In this study we investigated with a priming paradigm whether uni and bimanual actions presented as primes differently affected language processing. Animals' (self-moving entities) and plants' (not self-moving entities) names were used as targets. As prime we used grasping hands, presented both as static images and videos. The results showed an…

  2. Thermo-fluid-dynamics of turbulent boundary layer over a moving continuous flat sheet in a parallel free stream

    Science.gov (United States)

    Afzal, Bushra; Noor Afzal Team; Bushra Afzal Team

    2014-11-01

    The momentum and thermal turbulent boundary layers over a continuous moving sheet subjected to a free stream have been analyzed in two layers (inner wall and outer wake) theory at large Reynolds number. The present work is based on open Reynolds equations of momentum and heat transfer without any closure model say, like eddy viscosity or mixing length etc. The matching of inner and outer layers has been carried out by Izakson-Millikan-Kolmogorov hypothesis. The matching for velocity and temperature profiles yields the logarithmic laws and power laws in overlap region of inner and outer layers, along with friction factor and heat transfer laws. The uniformly valid solution for velocity, Reynolds shear stress, temperature and thermal Reynolds heat flux have been proposed by introducing the outer wake functions due to momentum and thermal boundary layers. The comparison with experimental data for velocity profile, temperature profile, skin friction and heat transfer are presented. In outer non-linear layers, the lowest order momentum and thermal boundary layer equations have also been analyses by using eddy viscosity closure model, and results are compared with experimental data. Retired Professor, Embassy Hotel, Rasal Ganj, Aligarh 202001 India.

  3. MHD Heat and Mass Transfer of Chemical Reaction Fluid Flow over a Moving Vertical Plate in Presence of Heat Source with Convective Surface Boundary Condition

    Directory of Open Access Journals (Sweden)

    B. R. Rout

    2013-01-01

    Full Text Available This paper aims to investigate the influence of chemical reaction and the combined effects of internal heat generation and a convective boundary condition on the laminar boundary layer MHD heat and mass transfer flow over a moving vertical flat plate. The lower surface of the plate is in contact with a hot fluid while the stream of cold fluid flows over the upper surface with heat source and chemical reaction. The basic equations governing the flow, heat transfer, and concentration are reduced to a set of ordinary differential equations by using appropriate transformation for variables and solved numerically by Runge-Kutta fourth-order integration scheme in association with shooting method. The effects of physical parameters on the velocity, temperature, and concentration profiles are illustrated graphically. A table recording the values of skin friction, heat transfer, and mass transfer at the plate is also presented. The discussion focuses on the physical interpretation of the results as well as their comparison with previous studies which shows good agreement as a special case of the problem.

  4. Progress in Computational Physics (PiCP) Vol 2 Coupled Fluid Flow in Energy, Biology and Environmental Research

    CERN Document Server

    Ehrhardt, Matthias

    2012-01-01

    This second volume contains both, the mathematical analysis of the coupling between fluid flow and porous media flow and state-of-the art numerical techniques, like tailor-made finite element and finite volume methods. Readers will come across articles devoted to concrete applications of these models in the field of energy, biology and environmental research.

  5. Use of charged particle beams for analysis of biological tissues and fluids

    International Nuclear Information System (INIS)

    PIXE has passed through its demonstration stage and matured into a viable tool supported by a reliable physics data base; the main problem to be solved at the outset of any new project is the preparation of a representative specimen of uniform thickness (or thinness) rather than any aspect of X-ray or accelerator physics or technology. The authors repeats the caution that minimum detection limits are strongly influenced by the nuclear reaction gamma-ray background from trace elements in the specimen. Thus experiment on a new target type is preferable to use of MDL calculations based on the background due to atomic processes (bremsstrahlung) in the known matrix. One hopes to see a more adventurous mood eg a move from routine blood serum analysis towards analyses of different blood fractions that concentrate specific trace elements. PIGE, while promising, must be regarded as developmental until the data-base of elemental gamma-ray yields is extended and made more accurate; work on fluorine in teeth clearly stands to profit from this technique. Finally, RBS, although scarcely used to date in any biological context, is clearly a powerful way of measuring major elemental ratios in mineralized tissues; however, RBS lacks the resolving power of PIXE and so is not a candidate for multi-trace element analysis

  6. Metabolism and toxicological analysis of synthetic cannabinoids in biological fluids and tissues.

    Science.gov (United States)

    Presley, B C; Gurney, S M R; Scott, K S; Kacinko, S L; Logan, B K

    2016-07-01

    Synthetic cannabinoids, which began proliferating in the United States in 2009, have gone through numerous iterations of modification to their chemical structures. More recent generations of compounds have been associated with significant adverse outcomes following use, including cognitive and psychomotor impairment, seizures, psychosis, tissue injury and death. These effects increase the urgency for forensic and public health laboratories to develop methods for the detection and identification of novel substances, and apply these to the determination of their metabolism and disposition in biological samples. This comprehensive review describes the history of the appearance of the drugs in the United States, discusses the naming conventions emerging to designate new structures, and describes the most prominent new compounds linked to the adverse effects now associated with their use. We review in depth the metabolic pathways that have been elucidated for the major members of each of the prevalent synthetic cannabinoid drug subclasses, the enzyme systems responsible for their metabolism, and the use of in silico approaches to assist in predicting and identifying the metabolites of novel compounds and drug subclasses that will continue to appear. Finally, we review and critique analytical methods applied to the detection of the drugs and their metabolites, including immunoassay screening, and liquid chromatography mass spectrometry confirmatory techniques applied to urine, serum, whole blood, oral fluid, hair, and tissues. PMID:27257717

  7. Evaluation of the solubility of the HPMC: PVA blends in biological fluids in vitro

    Directory of Open Access Journals (Sweden)

    Sara Elis Bianchi

    2011-01-01

    Full Text Available Polymers are often used to coat tablets for controlled drug release. The purpose of this study is to evaluate the solubility of the HPMC and PVA blend compared to isolated polymers in solutions with a pH of biological fluids (6 and 1.2 and the dissolution of capsules obtained using theophylline granules produced with the HPMC/PVA 25/75 blend as a matrix and as coating. HPMC is completely solubilized in the medium that simulates the pH of the stomach and intestine, and PVA is the polymer that allows controlling the solubility of the blend in the medium, with a differents pH. The dissolution time was monitored by UV absorbance with maximum theophylline at 269 nm. The theophylline was released immediately in the granules, and in the capsules 78.4% after 30 minutes and 97.4%, after 120 minutes. Thus, PVA can potentially control the drug solubilization, contributing to obtaining modified release systems.

  8. A nanofluidic bioarray chip for fast and high-throughput detection of antibodies in biological fluids

    Science.gov (United States)

    Lee, Jonathan; Gulzar, Naveed; Scott, Jamie K.; Li, Paul C. H.

    2012-10-01

    Immunoassays have become a standard in secretome analysis in clinical and research analysis. In this field there is a need for a high throughput method that uses low sample volumes. Microfluidics and nanofluidics have been developed for this purpose. Our lab has developed a nanofluidic bioarray (NBA) chip with the goal being a high throughput system that assays low sample volumes against multiple probes. A combination of horizontal and vertical channels are produced to create an array antigens on the surface of the NBA chip in one dimension that is probed by flowing in the other dimension antibodies from biological fluids. We have tested the NBA chip by immobilizing streptavidin and then biotinylated peptide to detect the presence of a mouse monoclonal antibody (MAb) that is specific for the peptide. Bound antibody is detected by an AlexaFluor 647 labeled goat (anti-mouse IgG) polyclonal antibody. Using the NBA chip, we have successfully detected peptide binding by small-volume (0.5 μl) samples containing 50 attomoles (100 pM) MAb.

  9. Electrochemically deposited and etched membranes with precisely sized micropores for biological fluids microfiltration

    International Nuclear Information System (INIS)

    This paper presents simple and economical, yet reliable techniques to fabricate a micro-fluidic filter for MEMS lab-on-chip (LoC) applications. The microporous filter is a crucial component in a MEMS LoC system. Microsized components and contaminants in biological fluids are selectively filtered using copper and silicon membranes with precisely controlled microsized pores. Two techniques were explored in microporous membrane fabrication, namely copper electroplating and electrochemical etching (ECE) of silicon. In the first technique, a copper membrane with evenly distributed micropores was fabricated by electroplating the copper layer on the silicon nitride membrane, which was later removed to leave the freestanding microporous membrane structure. The second approach involves the thinning of bulk silicon down to a few micrometers thick using KOH and etching the resulting silicon membrane in 5% HF by ECE to create micropores. Upon testing with nanoparticles of various sizes, it was observed that electroplated copper membrane passes nanoparticles up to 200 nm wide, while porous silicon membrane passes nanoparticles up to 380 nm in size. Due to process compatibility, simplicity, and low-cost fabrication, electroplated copper and porous silicon membranes enable synchronized microfilter fabrication and integration into the MEMS LoC system. (paper)

  10. DEVELOPMENT OF TETRAZEPAM-SELECTIVE MEMBRANE SENSORS AND THEIR APPLICATIONS IN PHARMACEUTICAL PREPARATIONS AND BIOLOGICAL FLUIDS

    Directory of Open Access Journals (Sweden)

    MAHA EL-TOHAMY

    2010-06-01

    Full Text Available The construction and performance characteristics of tetrazepam selective electrodes were developed. Two types of electrodes: plastic membrane I and coated wire II were constructed based on the incorporation of tetrazepam with phosphomolybdic acid. The influence of membrane composition, kind of plasticizer, pH of the test solution, soaking time, and foreign ions on the electrodes were investigated. The electrodes showed a Nernstain response with a mean calibration graph slope of 58.88±0.5 and 59.18±0.1 mV decade-1 at 25ºC for electrode I and II respectively, over tetrazepam concentration range from 5x10-3-1x10-6M and 1x10-2-1x10-6M, and with detection limit 5.0x10-7 M and 4.8 x10-7M for electrode I and II respectively. The constructed electrodes gave average selective precise and usable within the pH range 4-6. Interferences from common cations, alkaloids, sugars, amino acids and drug excipients were reported. The results obtained by the proposed electrodes were also applied successfully to the determination of the drug in pharmaceutical preparations and biological fluids.

  11. A simple kinetic spectrophotometric method for the determination of oxamniquine in formulations and spiked biological fluids.

    Science.gov (United States)

    Rizk, M; Belal, F; Ibrahim, F; Ahmed, S M; El-Enany, N M

    2000-08-15

    A simple and sensitive kinetic method for the determination of oxamniquine in pharmaceutical preparations and biological fluids was developed. The procedure is based upon a kinetic investigation of the oxidation reaction of the drug with alkaline potassium permanganate at room temperature for a fixed time of 20 min. The absorbance of the colored manganate ions was measured at 610 nm. Alternatively, the decrease in the absorbance of potassium permanganate after addition of the drug was measured at 525 nm. The absorbance concentration plots in both procedures were rectilinear over the range 0.5-4 microg ml(-1). The concentration of oxamniquine is calculated using the corresponding calibration equation for the fixed-time method. The determination of oxamniquine by fixed-concentration and rate-constant methods was feasible with the calibration equations obtained but the fixed time method had been found to be more applicable. Both procedures were applied to the determination of oxamniquine in formulations. The results obtained were in good agreement with those obtained using the official method. The fixed time method of 20 min was further applied to spiked human urine and plasma, the recoveries (%) were 100.94 +/- 0.57 and 98.07 +/- 0.88 for urine and plasma, respectively, at 610 nm, and 97.51 +/- 1.27 and 95.69 +/- 1.23 for urine and plasma, respectively, at 525 nm. PMID:10933544

  12. A Possible Mechanism of Biological Memories in terms of Quantum Fluids

    CERN Document Server

    Kobayashi, T

    2003-01-01

    A mechanism of memories, especially biological memories, is studied in terms of quantum fluids. Two-dimensional flows in central potentials $V_a(rho)=-a^2g_arho^{2(a-1)}$ ($anot=0$ and $rho=sqrt{x^2+y^2}$) have zero-energy eigenstates that degenerate infinitely for all $a$. It is shown that stable standing waves constructed from the zero-energy flows are confined in various types of polygons which can be the minimum units of memory systems. Vortex patterns awoken in the units by stimuli correspond to the memories of the stimuli. This memory system is not a system for preserving memories as usual but that for awaking memories. The system has interesting properties; (i) the absolute economy as for the energy consumption, (ii) the infinite variety for a huge number of memories, (iii) the perfect recovery of the system from any disturbances by stimuli, and (iv) the large flexibility in the construction of the system. A process for thinking is also proposed in terms of this memory system.

  13. 运动界面追踪的CVOFLS方法∗%A Coupled Volume of Fluid and Level Set (CVOFLS) Method for Tracking Moving Interfaces

    Institute of Scientific and Technical Information of China (English)

    周文; 欧阳洁; 崔立营

    2015-01-01

    A new coupled volume of fluid and level set (CVOFLS) method is proposed to capture the moving interface, in order to improve both the inaccurate evaluation of the interface normal vector in volume of fluid (VOF) method and the poor mass conservation ability in level set (LS) method. The method takes the advantages of the VOF method and the LS method. At each time step, the LS equation is solved at first, and the interface normal vector is evaluated via the LS signed distance function. Then the VOF equation is evaluated, and the interface reconstruction and the mass correction are performed by the volume fraction. The method is applied in some benchmark cases, such as rotation of the Zalesak’s disk, and stretching and shrinking of a circular fluid element. The numerical results indicate that the proposed CVOFLS method not only accurately captures the complex interface evolution and preserves the mass conservation, but also greatly improves the computational efficiency.%针对VOF方法中界面法向量计算不准确和level set方法中界面质量守恒性差的缺陷,本文提出了一种新的界面捕捉方法—CVOFLS (coupled volume of fluid and level set)方法.该方法吸收了VOF和level set两种方法的优点,在每个时间步内,首先求解level set输运方程,根据level set符号距离函数计算界面法向量;然后求解VOF输运方程,根据流体体积分数重构界面并校正流体质量.Zalesak圆盘旋转及圆面剪切的数值模拟表明,该方法能准确捕捉复杂的界面演化过程,具有良好的质量守恒性,并可以提高计算效率.

  14. The Influence of Nanoadditives on the Biological Properties and Chemical Composition of Process Fluids

    Directory of Open Access Journals (Sweden)

    Borůvková K.

    2015-12-01

    Full Text Available In this study process fluids were tested after the addition of nanoparticles. Cooling and lubricating process fluids are used in machining to reduce wear on tools, to increase machine performance and to improve product quality. The use of process fluids leads to their pollution and contamination. Nanoparticles were added to the process fluids in order to increase their antibacterial activity. The selected nanoparticles were nanoparticles of metallic silver. The process fluids were modified by the addition of silver nitrate and ascorbic acid. Reduction of silver nanoparticles in the volume of the fluid was achieved using UV. The modified fluids were tested for their cytotoxicity and changes in chemical composition. The cytotoxicity of process fluids was tested for the purpose of verifying whether the process fluids, which are in direct contact with the skin of the operator, affect the health of the operator. The cytotoxicity of the process fluids was tested on human fibroblast cells. Fibroblasts are the basic cells of fibrous tissue. The cytotoxicity was tested by measuring the cell viability and using XTT. Analysis of chemical composition was performed for the purpose of determining the individual substances in the process fluids and their chemical stability. Qualitative analysis of the process fluids was performed using gas chromatography mass spectrometry (GC - MS.

  15. BIO-PROGRAMMING PROSPECTS OF JAVA: A COMPUTATIONAL MOVE TOWARDS THE UNDERSTANDING OF THE BIOLOGICAL ASPECTS OF GENES AND PROTEINS

    Directory of Open Access Journals (Sweden)

    KALPANA RAJA

    2011-12-01

    Full Text Available Java is a powerful object oriented programming language that dominates many other programming languages for more than a decade. It is well designed and available as many executable technologies for software development such as Java Swing, Java Beans, Java Applets, Java Web Start, Java Database Connectivity (JDBC, Java Server Pages (JSP and Java 2 Enterprise Edition (J2EE. Beyond its usage in the IT sector, the language is prominent even in the new emerging fields including bioinformatics and computational biology.The biological data (genes and proteins from the biological and medical research is immense and require software professionals to mine them for new knowledge discovery. The knowledge to merge the programming concepts of Java to understand a wide range of biological concepts opens a new career challenge for many IT professionals. This paper introduces the implementation of the coding knowledge of Java in the field ofmolecular biology.

  16. Genetic markers in biological fluids for aging-related major neurocognitive disorder.

    Science.gov (United States)

    Castro-Chavira, S A; Fernandez, T; Nicolini, H; Diaz-Cintra, S; Prado-Alcala, R A

    2015-01-01

    Aging-related major neurocognitive disorder (NCD), formerly named dementia, comprises of the different acquired diseases whose primary deficit is impairment in cognitive functions such as complex attention, executive function, learning and memory, language, perceptual/motor skills, and social cognition, and that are related to specific brain regions and/or networks. According to its etiology, the most common subtypes of major NCDs are due to Alzheimer' s disease (AD), vascular disease (VaD), Lewy body disease (LBD), and frontotemporal lobar degeneration (FTLD). These pathologies are frequently present in mixed forms, i.e., AD plus VaD or AD plus LBD, thus diagnosed as due to multiple etiologies. In this paper, the definitions, criteria, pathologies, subtypes and genetic markers for the most common age-related major NCD subtypes are summarized. The current diagnostic criteria consider cognitive decline leading to major NCD or dementia as a progressive degenerative process with an underlying neuropathology that begins before the manifestation of symptoms. Biomarkers associated with this asymptomatic phase are being developed as accurate risk factor and biomarker assessments are fundamental to provide timely treatment since no treatments to prevent or cure NCD yet exist. Biological fluid assessment represents a safer, cheaper and less invasive method compared to contrast imaging studies to predict NCD appearance. Genetic factors particularly have a key role not only in predicting development of the disease but also the age of onset as well as the presentation of comorbidities that may contribute to the disease pathology and trigger synergistic mechanisms which may, in turn, accelerate the neurodegenerative process and its resultant behavioral and functional disorders. PMID:25731625

  17. Determination of hydroxyurea in capsules and biological fluids by ion-selective potentiometry and fluorimetry.

    Science.gov (United States)

    El-Kosasy, Amira M

    2003-01-01

    Two hydroxyurea selective electrodes were investigated with beta-cyclodextrin used as ionophore and either tetrakis (p-chlorophenyl) borate (electrode 1), or tetrakis [3,4-bis (trifluoromethyl) phenyl] borate (electrode 2), as a fixed anionic site in a polymeric matrix of carboxylated polyvinyl chloride. Linear responses of hydroxyurea within a concentration range of 10(-5)-10(-)3 M with slopes of 51.2 and 58.6 mV/decade with pH 3-6 were obtained by using electrodes 1 and 2, respectively. Two spectrofluorimetric methods involving the formation of drug-AI(III) complex (method 3) and drug-Mg(II) complex (method 4) at pH 5 were also investigated. These complexes emit fluorescence at wavelengths of 380 and 355 nm, after excitation at 305 nm, for AI and Mg complexes, respectively. The calibration graphs were rectilinear from 0.5 to 2.5 microg/mL for the AI complex and 1 to 5 microg/mL for the Mg complex. The 4 proposed methods display useful analytical characteristics for determination of hydroxyurea, with average recoveries of 100.2 +/- 0.83 and 99.4 +/- 1.81% in capsules and 99.7 +/- 0.70 and 99.4 +/- 1.25% in biological fluids for the potentiometric and fluorimetric methods, respectively. Results obtained by the proposed procedures were statistically analyzed and compared with those obtained by the U.S. Pharmacopeial method. The 4 proposed procedures were also used to determine the stability of the drug in the presence of its degradate, hydroxylamine.

  18. Rapid detection of Pseudomonas aeruginosa biomarkers in biological fluids using surface-enhanced Raman scattering

    Science.gov (United States)

    Wu, Xiaomeng; Chen, Jing; Zhao, Yiping; Zughaier, Susu M.

    2014-05-01

    Pseudomonas aeruginosa (PA) is an opportunistic pathogen that causes major infection not only in Cystic Fibrosis patients but also in chronic obstructive pulmonary disease and in critically ill patients in intensive care units. Successful antibiotic treatment of the infection relies on accurate and rapid identification of the infectious agents. Conventional microbiological detection methods usually take more than 3 days to obtain accurate results. We have developed a rapid diagnostic technique based on surface-enhanced Raman scattering to directly identify PA from biological fluids. P. aeruginosa strains, PAO1 and PA14, are cultured in lysogeny broth, and the SERS spectra of the broth show the signature Raman peaks from pyocyanin and pyoverdine, two major biomarkers that P. aeruginosa secretes during its growth, as well as lipopolysaccharides. This provides the evidence that the presence of these biomarkers can be used to indicate P. aeruginosa infection. A total of 22 clinical exhaled breath condensates (EBC) samples were obtained from subjects with CF disease and from non-CF healthy donors. SERS spectra of these EBC samples were obtained and further analyzed by both principle component analysis and partial least square-discriminant analysis (PLS-DA). PLS-DA can discriminate the samples with P. aeruginosa infection and the ones without P. aeruginosa infection at 99.3% sensitivity and 99.6% specificity. In addition, this technique can also discriminate samples from subject with CF disease and healthy donor with 97.5% sensitivity and 100% specificity. These results demonstrate the potential of using SERS of EBC samples as a rapid diagnostic tool to detect PA infection.

  19. Alkaline phosphatase inhibition based conductometric biosensor for phosphate estimation in biological fluids.

    Science.gov (United States)

    Upadhyay, Lata Sheo Bachan; Verma, Nishant

    2015-06-15

    Determination of phosphate ions concentration is very important from both, environmental and clinical point of view. In this study, a simple and novel conductometric biosensor for indirect determination of the phosphate ions in aqueous solution has been developed. The developed biosensor is based on the inhibition of immobilized alkaline phosphatase activity, in the presence of the phosphate ions. This is the first time we developed a mono-enzymatic biosensor for indirect estimation of phosphate ions. The developed biosensor showed a broad linear response (as compared to other reported biosensors) for phosphate ions in the range of 0.5-5.0 mM (correlation coefficient=0.995), with a detection limit of 50 µM. Different optimized parameters were obtained as the buffer concentration of 30 mM, substrate concentration of 1.0mM, and a pH of 9.0. All the optimized parameters were analyzed by analysis of variance, and were found to be statistically significant at a level of α=0.05. The developed biosensor is also suitable to determine the serum phosphate concentration, with a recovery of 86-104%, while a recovery of 102% was obtained from the water samples that were spiked with 500 µM phosphate. A relative standard deviation in the conductance response for five successive measurements (n=5) did not exceed 7%, with a shelf life of 30 days. With a lower detection limit and a higher recovery, the biosensor provides a facile approach for phosphate estimation in biological fluids.

  20. Highly selective electrode for potentiometric analysis of methadone in biological fluids and pharmaceutical formulations.

    Science.gov (United States)

    Ardeshiri, Moslem; Jalali, Fahimeh

    2016-06-01

    In order to develop a fast and simple procedure for methadone analysis in biological fluids, a graphite paste electrode (GPE) was modified with the ion-pair of methadone-phosphotungstic acid, and multiwalled carbon nanotubes (MWCNTs). Optimized composition of the electrode with respect to graphite powder:paraffin oil:MWCNTs:ion pair, was 58:30:8:4 (w/w%). The electrode showed a near-Nernstian slope of 58.9±0.3mV/decade for methadone in a wide linear range of 1.0×10(-8)-4.6×10(-3)M, with a detection limit of 1.0×10(-8)M. The electrode response was independent of pH in the range of 5-11, with a fast response time (~4s) at 25°C. The sensor showed high selectivity and was successfully applied to the determination of sub-micromolar concentrations of methadone in human blood serum and urine samples, with recoveries in the range of 95-99.8%. The average recovery of methadone from tablets (5mg/tablet) by using the proposed method was 98%. The life time of the modified electrode was more than 5months, due to the characteristic of GPE which can be cut off and fresh electrode surface be available. A titration procedure was performed for methadone analysis by using phosphotungstic acid, as titrating agent, which showed an accurate end point and 1:1 stoichiometry for the ion-pair formed (methadone:phosphotungstic acid). The simple and rapid procedure as well as excellent detection limit and selectivity are some of the advantages of the proposed sensor for methadone. PMID:27040192

  1. Supercritical Fluid Extraction and Ultra Performance Liquid Chromatography of Respiratory Quinones for Microbial Community Analysis in Environmental and Biological Samples

    OpenAIRE

    Koichi Fujie; Hiroyuki Daimon; Yoichi Atsuta; Muhammad Hanif

    2012-01-01

    Microbial community structure plays a significant role in environmental assessment and animal health management. The development of a superior analytical strategy for the characterization of microbial community structure is an ongoing challenge. In this study, we developed an effective supercritical fluid extraction (SFE) and ultra performance liquid chromatography (UPLC) method for the analysis of bacterial respiratory quinones (RQ) in environmental and biological samples. RQ profile analysi...

  2. Spectrophotometric Determination of Thioridazine Hydrochloride in Tablets and Biological Fluids by Ion-Pair and Oxidation Reactions

    OpenAIRE

    El-Didamony, Akram; Hafeez, Sameh

    2012-01-01

    Two simple, sensitive and selective spectrophotometric methods have been described for the determination of the psychoactive drug, thioridazine HCl in tablets and in biological fluids. The first method is based on the oxidation of thioridazine HCl with measured excess of KMnO4 under acidic conditions followed by the determination of unreacted oxidant using indigo carmine and methyl orange. The second method is based on the formation of ion-pair complexes with the acidic sulphophthalein dyes s...

  3. STUDY ON APPLICATION OF AERATION BIOLOGICAL FLUID TANK TECHNOLGY IN NH4+—N WASTE WATER TREATMENT

    Institute of Scientific and Technical Information of China (English)

    CHENYi; LUJian-guo

    2003-01-01

    This paper introduces an application of "Aeration biological fluid tank"technology (ABFT) for the treatment of waste water containing NH4+-N and high concentrated chemicals.Highlights were focused on the effects of dissolved oxygen,pH,temperature and retention time on waste water bilogical treatment in order to find out a new approach in treatment of waste time on containing high concentrated NH4+-N.

  4. A novel hybrid nano zerovalent iron initiated oxidation--biological degradation approach for remediation of recalcitrant waste metalworking fluids.

    Science.gov (United States)

    Jagadevan, Sheeja; Jayamurthy, Manickam; Dobson, Peter; Thompson, Ian P

    2012-05-01

    Disposal of operationally exhausted metal working fluids (MWF) through a biological route is an attractive option, since it is effective with relatively low energy demands. However, it is enormously challenging since these fluids are chemically complex, including the addition of toxic biocides which are added specifically to retard bio-deterioration whilst the fluids are operational. Nano-sized elemental iron represents a new generation of environmental remediation technologies. Laboratory scale batch studies were performed to test the degradation ability of a semi-synthetic metalworking fluid (MWF) wastewater (which was found to be resistant to initial bacterial treatment in specifically established bioreactors) by employing a novel hybrid approach. The approach was to combine the synergistic effects of nano zerovalent iron (nZVI) induced oxidation, followed by biodegradation, specifically for the remediation of recalcitrant components of MWF effluent. Addition of nZVI particles to oxygenated wastewater resulted in oxidation of organic contaminants present. Our studies confirmed 78% reduction in chemical oxygen demand (COD) by nZVI oxidation at pH 3.0 and 67% reduction in neutral pH (7.5), and 85% concurrent reduction in toxicity. Importantly, this low toxicity made the nZVI treated effluent more amenable for a second stage biological oxidation step. An overall COD reduction of 95.5% was achieved by the novel combined treatment described, demonstrating that nZVI oxidation can be exploited for enhancing the biodegradability of a recalcitrant wastewater in treatment processes. PMID:22365368

  5. A review of chromatographic methods for the determination of water- and fat-soluble vitamins in biological fluids.

    Science.gov (United States)

    Karaźniewicz-Łada, Marta; Główka, Anna

    2016-01-01

    Vitamins are an essential element of nutrition and thus contribute to human health. Vitamins catalyze many biochemical reactions and their lack or excess can cause health problems. Therefore, monitoring vitamin concentrations in plasma or other biological fluids may be useful in the diagnosis of various disorders as well as in the treatment process. Several chromatographic methods have been developed for the determination of these compounds in biological samples, including high-performance liquid chromatography with UV and fluorescence detection. Recently, high-performance liquid chromatography with tandem mass spectrometry methods have been widely used for the determination of vitamins in complex matrices because of their high sensitivity and selectivity. This method requires preconditioning of samples for analysis, including protein precipitation and/or various extraction techniques. The choice of method may depend on the desired cost, convenience, turnaround time, specificity, and accuracy of the information to be obtained. This article reviews the recently reported chromatographic methods used for determination of vitamins in biological fluids. Relevant papers published mostly during the last 5 years were identified by an extensive PubMed search using appropriate keywords. Particular attention was given to the preparation steps and extraction techniques. This report may be helpful in the selection of procedures that are appropriate for certain types of biological materials and analytes. PMID:26503668

  6. Modern methods for vancomycin determination in biological fluids by methods based on high-performance liquid chromatography--A review.

    Science.gov (United States)

    Javorska, Lenka; Krcmova, Lenka Kujovska; Solichova, Dagmar; Solich, Petr; Kaska, Milan

    2016-01-01

    Vancomycin is a glycopeptide antibiotic used in the therapy of severe bacterial infection. The monitoring of vancomycin levels is recommended because of its narrow therapeutic index and toxicity. This measurement is especially appropriate in patients with unstable renal functions, who receive high doses of vancomycin or present serious bacterial infections accompanied by important sequestration of liquids when it could be difficult to achieve the optimal therapeutic dose. Most of the methods for vancomycin determination in routine practice are immunoassays. However, chromatography-based techniques in combination with UV or mass spectrometry detection provide results with greater accuracy and precision also in complicated biological matrices. This review provides a detailed overview of modern approaches for the chromatographic separation of vancomycin in various biological samples and useful sample preparation procedures for vancomycin determination in various biological fluids.

  7. Carrier effects on tertiary nitrifying moving bed biofilm reactor: An examination of performance, biofilm and biologically produced solids.

    Science.gov (United States)

    Forrest, Daina; Delatolla, Robert; Kennedy, Kevin

    2016-01-01

    Increasingly stricter ammonia and nitrogen release regulations with respect to wastewater effluents are creating a need for tertiary treatment systems. The moving bed biofilm reactor (MBBR) is being considered as an upgrade option for an increasing number of wastewater treatment facilities due to its small footprint and ease of operation. Despite the MBBRs creation as a system to remove nitrogen, recent research on MBBR systems showing that the system's performance is directly related to carrier surface area and is irrespective of carrier shape and type has been performed exclusively on chemical oxygen demand (COD) removal systems. Furthermore, the influence of carrier type on the solids produced by MBBR systems has also been exclusively studied for COD removal systems. This work investigates the effects of three specific carrier types on ammonia removal rates, biofilm morphology, along with solids production and settleability of tertiary nitrifying MBBR systems. The study concludes that carrier type has no significant effect on tertiary nitrifying MBBR system performance under steady, moderate loading conditions. The research does however highlight the propensity of greater surface area to volume carriers to become clogged under high loading conditions and that the high surface area carriers investigated in this study required longer adjustment periods to changes in loading after becoming clogged.

  8. Deep ancient fluids in the continental crust and their impact on near-surface economic, environmental and biological systems.

    Science.gov (United States)

    Ballentine, Christopher; Warr, Oliver; Sutcliffe, Chelsea; McDermott, Jill; Fellowes, Jonathan; Holland, Greg; Mabry, Jennifer; Sherwood Lollar, Barbara

    2016-04-01

    With a few exceptions the mobility of water, oil and gas, provides for an ephemeral view of subsurface fluids relative to geological or planetary timescales. Aquifers supplying water for drinking and irrigation have mean residence ages from hundreds to tens of thousands of years; Hydrothermal systems can be active for hundreds of thousands to millions of years forming key mineral reserves; Sedimentary basin formation expels fluids during compaction and generates oil and gas on times scales of millions to hundreds of millions of years. Within these exemplar systems biological activity can play a crucial role by mediating system oxidation state: releasing arsenic into shallow groundwaters; precipitating ore bodies; generating methane; and biodegrading oil. It is becoming increasingly apparent that fluids resident in fractures and porespace in the crystalline basement underlying many of these systems can have a mean residence time that ranges from tens to hundreds of millions of years [1,2] to billions of years [3,4]. These fluids are highly saline and trace element rich; they are abundant in nitrogen, hydrogen, methane and helium and can contain microbes that have uniquely adapted to these isolated environments [5]. We are actively expanding discovery of sites with fluids exhibiting extreme age and have recently shown that these systems contribute to half of the terrestrial hydrogen production; a key component in biosphere energy and carbon cycles [6]. Tectonic or thermal release of these fluids can result in helium deposits; possible ore body generation and the inoculation of near-surface systems with microbial biota protected in the deep surface; the controls and rate of fluid release to shallow systems can fundamentally change the nature of some shallow systems. These deep ancient fluids represent a little tapped scientific resource for understanding how life survives and evolves in such isolation, how life is transported and communicates in extremis together and

  9. Advances in systems biology are enhancing our understanding of disease and moving us closer to novel disease treatments.

    Science.gov (United States)

    Schadt, Eric E; Zhang, Bin; Zhu, Jun

    2009-06-01

    With tens of billions of dollars spent each year on the development of drugs to treat human diseases, and with fewer and fewer applications for investigational new drugs filed each year despite this massive spending, questions now abound on what changes to the drug discovery paradigm can be made to achieve greater success. The high rate of failure of drug candidates in clinical development, where the great majority of these drugs fail due to lack of efficacy, speak directly to the need for more innovative approaches to study the mechanisms of disease and drug discovery. Here we review systems biology approaches that have been devised over the last several years to understand the biology of disease at a more holistic level. By integrating a diversity of data like DNA variation, gene expression, protein-protein interaction, DNA-protein binding, and other types of molecular phenotype data, more comprehensive networks of genes both within and between tissues can be constructed to paint a more complete picture of the molecular processes underlying physiological states associated with disease. These more integrative, systems-level methods lead to networks that are demonstrably predictive, which in turn provides a deeper context within which single genes operate such as those identified from genome-wide association studies or those targeted for therapeutic intervention. The more comprehensive views of disease that result from these methods have the potential to dramatically enhance the way in which novel drug targets are identified and developed, ultimately increasing the probability of success for taking new drugs through clinical development. We highlight a number of the integrative approaches via examples that have resulted not only in the identification of novel genes for diabetes and cardiovascular disease, but in more comprehensive networks as well that describe the context in which the disease genes operate. PMID:19363597

  10. An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues

    International Nuclear Information System (INIS)

    Highlights: ► Papers describing the determination of UV filters in fluids and tissues are reviewed. ► Matrix complexity and low amounts of analytes require effective sample treatments. ► The published papers do not cover the study of all the substances allowed as UV filters. ► New analytical methods for UV filters determination in these matrices are encouraged. - Abstract: Organic UV filters are chemical compounds added to cosmetic sunscreen products in order to protect users from UV solar radiation. The need of broad-spectrum protection to avoid the deleterious effects of solar radiation has triggered a trend in the cosmetic market of including these compounds not only in those exclusively designed for sun protection but also in all types of cosmetic products. Different studies have shown that organic UV filters can be absorbed through the skin after topical application, further metabolized in the body and eventually excreted or bioaccumulated. These percutaneous absorption processes may result in various adverse health effects, such as genotoxicity caused by the generation of free radicals, which can even lead to mutagenic or carcinogenic effects, and estrogenicity, which is associated with the endocrine disruption activity caused by some of these compounds. Due to the absence of official monitoring protocols, there is a demand for analytical methods that enable the determination of UV filters in biological fluids and tissues in order to retrieve more information regarding their behavior in the human body and thus encourage the development of safer cosmetic formulations. In view of this demand, there has recently been a noticeable increase in the development of sensitive and selective analytical methods for the determination of UV filters and their metabolites in biological fluids (i.e., urine, plasma, breast milk and semen) and tissues. The complexity of the biological matrix and the low concentration levels of these compounds inevitably impose sample

  11. An overview of the analytical methods for the determination of organic ultraviolet filters in biological fluids and tissues

    Energy Technology Data Exchange (ETDEWEB)

    Chisvert, Alberto, E-mail: alberto.chisvert@uv.es [Departamento de Quimica Analitica, Facultad de Quimica, Universitat de Valencia, Doctor Moliner St. 50, 46100 Burjassot, Valencia (Spain); Leon-Gonzalez, Zacarias [Unidad Analitica, Instituto de Investigacion Sanitaria Fundacion Hospital La Fe, 46009 Valencia (Spain); Tarazona, Isuha; Salvador, Amparo [Departamento de Quimica Analitica, Facultad de Quimica, Universitat de Valencia, Doctor Moliner St. 50, 46100 Burjassot, Valencia (Spain); Giokas, Dimosthenis [Laboratory of Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina (Greece)

    2012-11-08

    Highlights: Black-Right-Pointing-Pointer Papers describing the determination of UV filters in fluids and tissues are reviewed. Black-Right-Pointing-Pointer Matrix complexity and low amounts of analytes require effective sample treatments. Black-Right-Pointing-Pointer The published papers do not cover the study of all the substances allowed as UV filters. Black-Right-Pointing-Pointer New analytical methods for UV filters determination in these matrices are encouraged. - Abstract: Organic UV filters are chemical compounds added to cosmetic sunscreen products in order to protect users from UV solar radiation. The need of broad-spectrum protection to avoid the deleterious effects of solar radiation has triggered a trend in the cosmetic market of including these compounds not only in those exclusively designed for sun protection but also in all types of cosmetic products. Different studies have shown that organic UV filters can be absorbed through the skin after topical application, further metabolized in the body and eventually excreted or bioaccumulated. These percutaneous absorption processes may result in various adverse health effects, such as genotoxicity caused by the generation of free radicals, which can even lead to mutagenic or carcinogenic effects, and estrogenicity, which is associated with the endocrine disruption activity caused by some of these compounds. Due to the absence of official monitoring protocols, there is a demand for analytical methods that enable the determination of UV filters in biological fluids and tissues in order to retrieve more information regarding their behavior in the human body and thus encourage the development of safer cosmetic formulations. In view of this demand, there has recently been a noticeable increase in the development of sensitive and selective analytical methods for the determination of UV filters and their metabolites in biological fluids (i.e., urine, plasma, breast milk and semen) and tissues. The complexity of

  12. Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

    Directory of Open Access Journals (Sweden)

    Redzic Zoran

    2011-01-01

    Full Text Available Abstract Efficient processing of information by the central nervous system (CNS represents an important evolutionary advantage. Thus, homeostatic mechanisms have developed that provide appropriate circumstances for neuronal signaling, including a highly controlled and stable microenvironment. To provide such a milieu for neurons, extracellular fluids of the CNS are separated from the changeable environment of blood at three major interfaces: at the brain capillaries by the blood-brain barrier (BBB, which is localized at the level of the endothelial cells and separates brain interstitial fluid (ISF from blood; at the epithelial layer of four choroid plexuses, the blood-cerebrospinal fluid (CSF barrier (BCSFB, which separates CSF from the CP ISF, and at the arachnoid barrier. The two barriers that represent the largest interface between blood and brain extracellular fluids, the BBB and the BCSFB, prevent the free paracellular diffusion of polar molecules by complex morphological features, including tight junctions (TJs that interconnect the endothelial and epithelial cells, respectively. The first part of this review focuses on the molecular biology of TJs and adherens junctions in the brain capillary endothelial cells and in the CP epithelial cells. However, normal function of the CNS depends on a constant supply of essential molecules, like glucose and amino acids from the blood, exchange of electrolytes between brain extracellular fluids and blood, as well as on efficient removal of metabolic waste products and excess neurotransmitters from the brain ISF. Therefore, a number of specific transport proteins are expressed in brain capillary endothelial cells and CP epithelial cells that provide transport of nutrients and ions into the CNS and removal of waste products and ions from the CSF. The second part of this review concentrates on the molecular biology of various solute carrier (SLC transport proteins at those two barriers and underlines

  13. Derivatization reactions in the gas—liquid chromatographic analysis of drugs in biological fluids

    NARCIS (Netherlands)

    Hulshoff, A.; Lingeman, H.

    1984-01-01

    Alkylation, acylation, silylation and other derivatization reactions applied to the gas chromatographic analysis of drugs in biological matrices are reviewed. Reaction conditions are discussed in relation to reaction mechanisms. Detector-oriented labelling of drugs, and derivatization with chiral re

  14. Fluid Chemistry and Associated Biological Potential in Diverse Serpentinizing Systems of New Zealand’s South Island

    Science.gov (United States)

    Cardace, D.; Hoehler, T.; Foster, A. L.

    2009-12-01

    Serpentinization - the aqueous alteration of ultramafic rocks - generates H2 and other reduced compounds capable of fueling microbial metabolism, and is therefore considered a potential mechanism for the long-term support of subsurface life. This potential may be constrained, however, by rates of serpentinization (corresponding to magnitude of energy flux) and by potentially detrimental co-evolving fluid chemistry - particularly elevated pH. We conducted an initial characterization of the chemistry and associated biological potential of springs and gas seeps associated with two distinct serpentinizing systems in the northwestern Fiordland of New Zealand’s south island. Fluid or gas chemistry, including H2 concentrations, was characterized and used to model energy availability associated with several potential microbial metabolisms; the presence of organisms having targeted metabolisms (methanogenesis, sulfate reduction, iron reduction) was assayed in parallel using quantitative PCR. Serpentinization in Fiordland was tracked in two specific locations. First, the Anita Ultramafites (AU) exposed at Poison Bay are likely ultramafic intrusive rocks within a 3-4 km wide shear zone of deformed gneisses and dunite mylonites (Hill, 1995), which have undergone amphibolite facies metamorphism during continental extension (Gibson, 1990) and now generate gas that escapes from depth along fault networks. Second, along the western edge of the Dun Mountain Ophiolite Belt in the Cascade River Valley, located NW of Milford Sound, deep fluids interact structurally with the Alpine Fault in the ultramafic subsurface; where those fluids escape to the surface, travertine-depositing subaerial springs cover an area of ~100 m2 on a serpentinized talus slope (Aitchison, 1985). Seep fluids from both sites have high pH due to hydroxide solution related to serpentinization, and CaCO3 terraces at the latter site testify to elevated Ca in fluids that reacts with atmospheric CO2 at Earth

  15. Determination of captopril in pharmaceutical preparation and biological fluids using two- and three-way chemometrics methods

    Institute of Scientific and Technical Information of China (English)

    Nahid Ghasemi; Ali Niazi

    2007-01-01

    Spectrophotometric method has been developed for the direct quantitative determination of captopril in pharmaceutical preparation and biological fluids (human plasma and urine) samples. The method was accomplished based on parallel factor analysis (PARAFAC) and partial least squares (PLS). The study was carried out in the pH range from 2.0 to 12.8 and with a concentration from 0.70 to 61.50 μg mL-1 of captopril. Multivariate calibration models such as PLS at various pH and PARAFAC were elaborated from ultraviolet spectra deconvolution and captopril determination. The best models for this system were obtained with PARAFAC and PLS at pH 2.0. The applications of the method for determination of real samples were evaluated by analysis of captopril in pharmaceutical preparations and biological fluids with satisfactory results. The accuracy of the method, evaluated through the RMSEP, was 0.5801 for captopril with best calibration curve by PARAFAC and 0.6168 for captopril with PLS at pH 2.0 model.

  16. Preformulation and stability in biological fluids of the retrocyclin RC-101, a potential anti-HIV topical microbicide

    Directory of Open Access Journals (Sweden)

    Conrads Thomas P

    2011-07-01

    Full Text Available Abstract Background RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aimed to investigate RC-101 stability under several conditions including the presence of human vaginal fluids (HVF, enabling the efficient design of a safe and effective microbicide product. Stability studies (temperature, pH, and oxidation were performed by HPLC, Circular Dichroism, and Mass Spectrometry (LC-MS/MS. Additionally, the effect of HVF on formulated RC-101 was evaluated with fluids collected from healthy volunteers, or from subjects with bacterial vaginosis (BV. RC-101 was monitored by LC-MS/MS for up to 72 h. Results RC-101 was stable at pH 3, 4, and 7, at 25 and 37°C. High concentrations of hydrogen peroxide resulted in less than 10% RC-101 reduction over 24 h. RC-101 was detected 48 h after incubation with normal HVF; however, not following incubation with HVF from BV subjects. Conclusions Our results emphasize the importance of preformulation evaluations and highlight the impact of HVF on microbicide product stability and efficacy. RC-101 was stable in normal HVF for at least 48 h, indicating that it is a promising candidate for microbicide product development. However, RC-101 stability appears compromised in individuals with BV, requiring more advanced formulation strategies for stabilization in this environment.

  17. Influence of the biological fluid on the corrosion of dental amalgam

    OpenAIRE

    Brett, Christopher M. A.; Ioanitescu, Iulia; Trandafir, Florin

    2004-01-01

    An electrochemical study of corrosion of Tytin® dental amalgam was carried out in electrolytes similar to body fluids: artificial saliva with or without lactic acid, a polymer-containing product of the same composition as Glandosane® and in Krebs-Ringer solution. The electrochemical techniques of open circuit potential, polarisation curves, cyclic voltammetry and electrochemical impedance were employed as a function of immersion time to characterise the surface processes occurring and bring o...

  18. New rheometer geometry to characterize delicate biological fluids in-situ

    Science.gov (United States)

    Connelly, Kelly; Young, Ethan; Hubschman, Jean-Pierre; Eldredge, Jeff; Kavehpour, Pirouz

    2015-11-01

    The vitreous humor is a viscoelastic gel-like fluid that fills and maintains the structure of the eye. Changes in the structure of the network of macromolecules in vitreous occurs naturally during ageing causing pathological conditions such as retinal tears that may lead to blindness. Vitrectomy surgery is a common procedure to remove problematic vitreous from the eye, but must be carefully performed to prevent iatrogenic retinal tears. Minimizing invasiveness and surgical time depends on the viscoelastic behavior of vitreous as it flows from the eye out through a small gauge needle. Rheology has been used to correlate relevant viscoelastic fluid properties with the macromolecular structure previously using parallel plate rheometer geometries, and now with a new patented probe geometry. This improves upon plate geometries because measurements are in situ, so removal of the vitreous from the eye is not necessary. Creep rheological experiments with the probe indicate a region of elastic behavior exists at shorter timescales and steady state apparent viscosity at longer timescales. In-situ creep tests advance understanding of how macromolecular structure alters viscoelasticity, which may allow better predictions of fluid flow during vitrectomy in the future. This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE-1144087.

  19. Polyelectrolyte properties of filamentous biopolymers and their consequences in biological fluids.

    Science.gov (United States)

    Janmey, Paul A; Slochower, David R; Wang, Yu-Hsiu; Wen, Qi; Cēbers, Andrejs

    2014-03-14

    Anionic polyelectrolyte filaments are common in biological cells. DNA, RNA, the cytoskeletal filaments F-actin, microtubules, and intermediate filaments, and polysaccharides such as hyaluronan that form the pericellular matrix all have large net negative charge densities distributed over their surfaces. Several filamentous viruses with diameters and stiffnesses similar to those of cytoskeletal polymers also have similar negative charge densities. Extracellular protein filaments such collagen, fibrin and elastin, in contrast, have notably smaller charge densities and do not behave as highly charged polyelectrolytes in solution. This review summarizes data that demonstrate generic counterion-mediated effects on four structurally unrelated biopolymers of similar charge density: F-actin, vimentin, Pf1 virus, and DNA, and explores the possible biological and pathophysiological consequences of the polyelectrolyte properties of biological filaments.

  20. GOMA - A full-Newton finite element program for free and moving boundary problems with coupled fluid/solid momentum, energy, mass, and chemical species transport: User`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Schunk, P.R.; Sackinger, P.A.; Rao, R.R. [and others

    1996-01-01

    GOMA is a two- and three-dimensional finite element program which excels in analyses of manufacturing processes, particularly those involving free or moving interfaces. Specifically, the full-Newton-coupled heat, mass, momentum, and pseudo-solid mesh motion algorithm makes GOMA ideally suited for simulating processes in which the bulk fluid transport is closely coupled to the interfacial physics. Examples include, but are not limited to, coating and polymer processing flows, soldering, crystal growth, and solid-network or solution film drying. The code is based on the premise that any boundary can be (1) moving or free, with an apriori unknown position dictated by the distinguishing physics, (2) fixed, according to a global analytical representation, or (3) moving in time and space under user-prescribed kinematics. The goal is to enable the user to predict boundary position or motion simultaneously with the physics of the problem being analyzed and to pursue geometrical design studies and fluid-structure interaction problems. The moving mesh algorithm treats the entire domain as a computational Lagrangian solid that deforms subject to the physical principles which dictate boundary position. As an added benefit, the same Lagrangian solid mechanics can be exploited to solve multi-field problems for which the solid motion and stresses interact with other transport phenomena, either within the same material phase (e.g. shrinking coating) or in neighboring material phases (e.g. flexible blade coating). Thus, analyses of many fluid-structure interaction problems and deformable porous media problems are accessible. This document serves as a user`s guide and reference for GOMA and provides a brief overview of GOMA`s capabilities, theoretical background, and classes of problems for which it is targeted.

  1. Banking of biological fluids for studies of disease-associated protein biomarkers

    DEFF Research Database (Denmark)

    Rasmussen, Anne-Sofie Schrohl; Würtz, Sidse Ørnbjerg; Kohn, Elise;

    2008-01-01

    With the increasing demand of providing personalized medicine the need for biobanking of biological material from individual patients has increased. Such samples are essential for molecular research aimed at characterizing diseases at several levels ranging from epidemiology and diagnostic and pr...

  2. Application of biological design criteria and computational fluid dynamics to investigate fish survival in Kaplan turbines

    Energy Technology Data Exchange (ETDEWEB)

    Garrison, Laura A. [Voith Siemens Hydro Power Generation, Inc., York, PA (United States); Fisher, Jr., Richard K. [Voith Siemens Hydro Power Generation, Inc., York, PA (United States); Sale, Michael J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cada, Glenn [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2002-07-01

    One of the contributing factors to fish injury in a turbine environment is shear stress. This paper presents the use of computational fluid dynamics (CFD) to display and quantify areas of elevated shear stress in the Wanapum Kaplan turbine operating at four different flow conditions over its operating range. CFD observations will be compared to field test observations at the same four flow conditions. Methods developed here could be used to facilitate the design of turbines and related water passages with lower risks of fish injury.

  3. Relative solubiolity in simulated biological fluids of PuO2 on air sampler filters

    International Nuclear Information System (INIS)

    An ultrafiltration method was developed to estimate the solubility of PuO2 on an air filter in simulated lung fluid (SLF), simulated gastric juice (SGJ), and in 1% DTPA. After a very rapid early appearance in the filtrate, both 238Pu and 239Pu showed similar rates of low ultrafilterability. The amount of 239Pu appearing during the first day of ultrafiltration was 10 times less in SLF than in SGJ or DTPA, although the amount of 238Pu was similar for the three solvents. The method used to estimate solubility requires only about 1000 dpm of plutonium alpha radiation per sample

  4. Harmonisation of chemical and biological process in development of a hybrid technology for treatment of recalcitrant metalworking fluid.

    Science.gov (United States)

    Jagadevan, Sheeja; Dobson, Peter; Thompson, Ian P

    2011-10-01

    Disposal of operationally exhausted metalworking fluids (MWFs) is enormously challenging. In this study the feasibility of employing a sequential Fenton-biological oxidation for the treatment of recalcitrant components of MWF wastewater was investigated. A statistical experimental design was employed to address Fenton reagent (H₂O₂, Fe²⁺) dose optimisation which ensured minimal concentrations of the reagents, thus making the treatment environmentally less toxic to subsequent biological steps and economically viable. This was achieved by employing a five-level-two-variable central composite experimental design. The results demonstrated that Fenton pre-treatment of the MWF effluent greatly improved biodegradability index (BOD₅)/COD increased from 0.160 to 0.538) with a synchronous lowering in the toxicity of the wastewater, making the recalcitrant component more amenable to subsequent biological treatment. An overall decrease of 92% and 86% in chemical oxygen demand (COD) and total organic carbon (TOC), respectively, was achieved by the two-step treatment method developed. PMID:21831632

  5. Photoemission study of metallic iron nanoparticles surface aging in biological fluids. Influence on biomolecules adsorption

    Energy Technology Data Exchange (ETDEWEB)

    Canivet, L.; Denayer, F.O. [Université de Lille 2, Droit et Santé, 42 rue P. Duez, 59000 Lille (France); Champion, Y.; Cenedese, P. [CNRS-ICMPE, 2 rue H. Dunant, 94320 Thiais (France); Dubot, P., E-mail: pdubot@icmpe.cnrs.fr [CNRS-ICMPE, 2 rue H. Dunant, 94320 Thiais (France)

    2014-07-01

    Iron nanoparticles (nFe) prepared by vaporization and cryogenic condensation process (10–100 nm) has been exposed to Hank's balanced salt solution (HBSS) and the B-Ali cell growth fluids. These media can be used for cellular growth to study nFe penetration through cell membrane and its induced cytotoxicity. Surface chemistry of nFe exposed to such complex fluids has been characterized as the nanoparticles surface can be strongly changed by adsorption or corrosion processes before reaching intracellular medium. Particle size and surface chemistry have been characterized by scanning electron microscopy (SEM) and high-resolution X-ray photoelectron spectroscopy (HR-XPS). Exposition of nFe particles to growth and differentiation media leads to the formation of an oxy-hydroxide layer containing chlorinated species. We found that the passivated Fe{sub 2}O{sub 3} layer of the bare nFe particles is rapidly transformed into a thicker oxy-hydroxide layer that has a greater ability to adsorb molecular ions or ionic biomolecules like proteins or DNA.

  6. Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine

    Directory of Open Access Journals (Sweden)

    Kerry Rennie

    2012-01-01

    Full Text Available The amniotic membrane (AM and amniotic fluid (AF have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition, the discovery of cell populations in AM and AF which are widely accessible, nontumorigenic and capable of differentiating into a variety of cell types has stimulated a flurry of research aimed at characterizing the cells and evaluating their potential utility in regenerative medicine. While a major focus of research has been the use of amniotic membrane and fluid in tissue engineering and cell replacement, AM- and AF-derived cells may also have capabilities in protecting and stimulating the repair of injured tissues via paracrine actions, and acting as vectors for biodelivery of exogenous factors to treat injury and diseases. Much progress has been made since the discovery of AM and AF cells with stem cell characteristics nearly a decade ago, but there remain a number of problematic issues stemming from the inherent heterogeneity of these cells as well as inconsistencies in isolation and culturing methods which must be addressed to advance the field towards the development of cell-based therapies. Here, we provide an overview of the recent progress and future perspectives in the use of AM- and AF-derived cells for therapeutic applications.

  7. Electroanalysis of antitubercular drugs in pharmaceutical dosage forms and biological fluids: a review.

    Science.gov (United States)

    Thapliyal, Neeta; Karpoormath, Rajshekhar V; Goyal, Rajendra N

    2015-01-01

    Tuberculosis remains a major global public health problem. Given the need for extensive analysis of antitubercular drugs, the development of sensitive, reliable and facile analytical methods to determine these compounds becomes necessary. Electrochemical techniques have inherent advantages over other well-established analytical methods, this review aiming to provide an updated overview of the latest trends (from 2006 till date) in the voltammetric determination of antitubercular drugs. Furthermore, the advantages and limitations of these methods are critically discussed. The review reveals that in spite of using a variety of chemically modified electrodes to determine antitubercular drugs, there is still a dearth of applicability of the voltammetric methods to quantify these compounds in human body fluids, especially in blood plasma.

  8. Improved analysis of picomole quantities of lithium, sodium, and potassium in biological fluids.

    Science.gov (United States)

    Shalmi, M; Kibble, J D; Day, J P; Christensen, P; Atherton, J C

    1994-10-01

    The analysis of picomolar lithium, sodium, and potassium by electrothermal atomic absorption spectrophotometry was studied using a Perkin-Elmer Zeeman 3030 spectrophotometer. With ordinary pyrolytically coated graphite tubes, a number of interference effects associated with the sample matrix were observed. In particular, the lithium and potassium absorbance signal was depressed by chloride, an effect shown to be dependent on the preatomization heating. When an in situ tantalum-coated atomization surface was used, matrix interferences observed in lithium and potassium analyses were abolished, and the linear range for the potassium assay was extended. Technical difficulties encountered during sodium analysis at the primary wavelength were effectively circumvented by analysis at a less-sensitive wavelength (303.3 nm), at which tantalum coating also prevented significant chloride interference. The improved microanalyses were employed to reevaluate the handling of lithium, sodium, and potassium along the proximal convoluted tubule (PCT) of the anesthetized rat. The average tubular fluid-to-plasma concentration ratios for lithium [(TF/P)Li] and sodium [(TF/P)Na] were 1.13 +/- 0.08, n = 26, and 0.99 +/- 0.07 (n = 26), respectively. The tubular fluid-to-plasma ultrafiltrate concentration ratio for potassium [(TF/UF)K] was 1.09 +/- 0.05 (n = 13). Ratios did not change significantly with puncture site along the PCT for any of the ions. (TF/P)Li and (TF/UF)K were significantly greater than (TF/P)Na, indicating that lithium and potassium reabsorption do not directly parallel sodium reabsorption in the PCT. PMID:7943365

  9. Interaction of uranium(VI) with bioligands present in human biological fluids. The case study of urea and uric acid

    Energy Technology Data Exchange (ETDEWEB)

    Osman, A.A.A.; Geipel, G.; Bernhard, G. [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. of Resource Ecology

    2013-05-01

    The complexation of uranium(VI) with bioligands found in human biological fluids, viz, urea and uric acid in aqueous solutions, has been investigated using time-resolved laser-induced fluorescence spectroscopy (TRLFS) at room temperature, I = 0.1 M (NaClO4) and pH (3 for uric acid; 4 for urea). In both complex systems a static quench effect with increasing ligand concentration and no peaks shift upon complexation were observed. With uranium(VI) both ligands formed a fairly weak 1:1 complex with average stability constants of log {beta}{sub 110} = 4.67 {+-} 0.29 for uric acid and log {beta}{sub 110} = 3.79 {+-} 0.15 and 2.12 {+-} 0.18 for relatively low and relatively high urea concentrations, respectively. Application of the newly generated data on the U(VI) speciation modelling in biofluids, e.g., human urine was also discussed.

  10. Sensitive determination of domperidone in biological fluids using a conductive polymer modified glassy carbon electrode

    International Nuclear Information System (INIS)

    A simple and sensitive method for domperidone (DP) determination has been developed by electropolymerizing a polymer film on the surface of glassy carbon electrode (GCE) in acidic solution using cyclic voltammetry. The modified sensor was characterized by Field Emission Scanning Electron Microscopy (FE-SEM) and Electrochemical Impedance Spectroscopy (EIS). The electrochemical measurements were carried out using square wave voltammetry and cyclic voltammetry. The modified sensor exhibited an excellent catalytic response towards the oxidation of DP with a well-defined oxidation peak at 840 mV. The modified sensor exhibited linear calibration curve for DP over a concentration range of 0.1 μM to 100 μM in phosphate buffer solution of pH 7.2 with detection limit of 12.0 nM. The sensor was capable to determine DP effectively without any interference from the common metabolites like ascorbic acid, uric acid, xanthine and hypoxanthine. The analytical utilities of the sensor have been demonstrated by determining the DP in human fluids and pharmaceutical samples. Further, the modified sensor displayed voltammetric responses with high sensitivity, good selectivity and reproducibility which make it suitable for clinical diagnosis

  11. Analytical Strategies for the Determination of Norepinephrine Reuptake Inhibitors in Pharmaceutical Formulations and Biological Fluids.

    Science.gov (United States)

    Saka, Cafer

    2016-01-01

    Norepinephrine reuptake inhibitors (NRIs) are a class of antidepressant drugs that act as reuptake inhibitors for the neurotransmitters norepinephrine and epinephrine. The present review provides an account of analytical methods published in recent years for the determination of NRI drugs. NRIs are atomoxetine, reboxetine, viloxazine and maprotiline. NRIs with less activity at other sites are mazindol, bupropion, tapentadol, and teniloxazine. This review focuses on the analytical methods including chromatographic, spectrophotometric, electroanalytical, and electrophoresis techniques for NRI analysis from pharmaceutical formulations and biological samples. Among all of the published methods, liquid chromatography with UV-vis or MS-MS detection is the most popular technique. The most the common sample preparation techniques in the analytical methods for NRIs include liquid-liquid extraction and solid-phase extraction. Besides the analytical methods for single components, some of the simultaneous determinations are also included in this review. PMID:26857446

  12. Corrosion resistance of titanium and some dental implant alloy in biological fluids

    International Nuclear Information System (INIS)

    The main purpose of this paper is the study of the long-term corrosion resistance of the titanium and dental alloy Ti-5Al-4V in physiological serum and artificial saliva of different pH values (acid and neutral) at 37 deg. C, reproducing the various biological environments that can be in contact with dental implants. The potentiostatic, potentiodynamic and linear polarisation measurements have been used to characterise the corrosion resistance of these materials during a period of about 1500 exposure hours. Also, the variation of open circuit potentials in time and with pH has been recorded for the same term. The potential gradients resulted from the pH changes were calculated; also, their variation in time were simulated for extreme, hypothetical conditions. The corrosion rates were determined. (authors)

  13. Analytical Strategies for the Determination of Norepinephrine Reuptake Inhibitors in Pharmaceutical Formulations and Biological Fluids.

    Science.gov (United States)

    Saka, Cafer

    2016-01-01

    Norepinephrine reuptake inhibitors (NRIs) are a class of antidepressant drugs that act as reuptake inhibitors for the neurotransmitters norepinephrine and epinephrine. The present review provides an account of analytical methods published in recent years for the determination of NRI drugs. NRIs are atomoxetine, reboxetine, viloxazine and maprotiline. NRIs with less activity at other sites are mazindol, bupropion, tapentadol, and teniloxazine. This review focuses on the analytical methods including chromatographic, spectrophotometric, electroanalytical, and electrophoresis techniques for NRI analysis from pharmaceutical formulations and biological samples. Among all of the published methods, liquid chromatography with UV-vis or MS-MS detection is the most popular technique. The most the common sample preparation techniques in the analytical methods for NRIs include liquid-liquid extraction and solid-phase extraction. Besides the analytical methods for single components, some of the simultaneous determinations are also included in this review.

  14. Crystallo-optic diagnostics method of the soft laser-induced effects in biological fluids

    Science.gov (United States)

    Skopinov, S. A.; Yakovleva, S. V.

    1991-05-01

    Presently, it is well known that individual cells"2 and higher organisms3'4 exhibit a marked response to soft laser irradiation in certain parts of the visible and near infrared spectral ranges. Broad clinical applications of laser therapy and slow progress in understanding of the physical, chemical and biological mechanisms of this phenomenon make the task to search new methods of objectivisation of laser-induces bioeffects very insistent. In this paper we give a short review of the methods of structural-optical diagnostics of the soft laser-induced effects in biofluids (blood and its fractions, saliva, juices, mucuses, exudations, etc.) and suggest their applications in experimental and clinical studies of the soft laser bioeffects.

  15. Retaining activity of enzymes after capture and extraction within a single-drop of biological fluid using immunoaffinity membranes.

    Science.gov (United States)

    Shimazaki, Youji; Sato, Yuki

    2016-05-15

    The purpose of this study was the measurement of enzyme activity within a single-drop of biological fluid after micropurification. Esterase and lactate dehydrogenase (LDH) retained their enzymatic activities after being captured by membrane-immobilized antibodies, which were prepared by non-denaturing two-dimensional electrophoresis, transferred to polyvinylidene difluoride and then stained by Ponceau S. The activities of both enzymes were also measured after being captured by antibodies and biotinylated antibodies bound to membrane-immobilized protein A or avidin, respectively. After esterase and LDH were captured from biological samples by membrane-immobilized protein A or avidin, their activities were semi-quantitatively measured on the surface of the membrane using fluorescence determination. More than 51% of enzyme activities were retained even after the enzymes were captured by biotinylated antibody bound to membrane-immobilized avidin and eluted by rinsing with 5μL of 1% Triton X-100, compared with the activities of the enzyme on the immunoaffinity membrane.

  16. Supercritical fluid extraction and ultra performance liquid chromatography of respiratory quinones for microbial community analysis in environmental and biological samples.

    Science.gov (United States)

    Hanif, Muhammad; Atsuta, Yoichi; Fujie, Koichi; Daimon, Hiroyuki

    2012-01-01

    Microbial community structure plays a significant role in environmental assessment and animal health management. The development of a superior analytical strategy for the characterization of microbial community structure is an ongoing challenge. In this study, we developed an effective supercritical fluid extraction (SFE) and ultra performance liquid chromatography (UPLC) method for the analysis of bacterial respiratory quinones (RQ) in environmental and biological samples. RQ profile analysis is one of the most widely used culture-independent tools for characterizing microbial community structure. A UPLC equipped with a photo diode array (PDA) detector was successfully applied to the simultaneous determination of ubiquinones (UQ) and menaquinones (MK) without tedious pretreatment. Supercritical carbon dioxide (scCO(2)) extraction with the solid-phase cartridge trap proved to be a more effective and rapid method for extracting respiratory quinones, compared to a conventional organic solvent extraction method. This methodology leads to a successful analytical procedure that involves a significant reduction in the complexity and sample preparation time. Application of the optimized methodology to characterize microbial communities based on the RQ profile was demonstrated for a variety of environmental samples (activated sludge, digested sludge, and compost) and biological samples (swine and Japanese quail feces). PMID:22391598

  17. Supercritical fluid extraction and ultra performance liquid chromatography of respiratory quinones for microbial community analysis in environmental and biological samples.

    Science.gov (United States)

    Hanif, Muhammad; Atsuta, Yoichi; Fujie, Koichi; Daimon, Hiroyuki

    2012-03-05

    Microbial community structure plays a significant role in environmental assessment and animal health management. The development of a superior analytical strategy for the characterization of microbial community structure is an ongoing challenge. In this study, we developed an effective supercritical fluid extraction (SFE) and ultra performance liquid chromatography (UPLC) method for the analysis of bacterial respiratory quinones (RQ) in environmental and biological samples. RQ profile analysis is one of the most widely used culture-independent tools for characterizing microbial community structure. A UPLC equipped with a photo diode array (PDA) detector was successfully applied to the simultaneous determination of ubiquinones (UQ) and menaquinones (MK) without tedious pretreatment. Supercritical carbon dioxide (scCO(2)) extraction with the solid-phase cartridge trap proved to be a more effective and rapid method for extracting respiratory quinones, compared to a conventional organic solvent extraction method. This methodology leads to a successful analytical procedure that involves a significant reduction in the complexity and sample preparation time. Application of the optimized methodology to characterize microbial communities based on the RQ profile was demonstrated for a variety of environmental samples (activated sludge, digested sludge, and compost) and biological samples (swine and Japanese quail feces).

  18. Supercritical Fluid Extraction and Ultra Performance Liquid Chromatography of Respiratory Quinones for Microbial Community Analysis in Environmental and Biological Samples

    Directory of Open Access Journals (Sweden)

    Koichi Fujie

    2012-03-01

    Full Text Available Microbial community structure plays a significant role in environmental assessment and animal health management. The development of a superior analytical strategy for the characterization of microbial community structure is an ongoing challenge. In this study, we developed an effective supercritical fluid extraction (SFE and ultra performance liquid chromatography (UPLC method for the analysis of bacterial respiratory quinones (RQ in environmental and biological samples. RQ profile analysis is one of the most widely used culture-independent tools for characterizing microbial community structure. A UPLC equipped with a photo diode array (PDA detector was successfully applied to the simultaneous determination of ubiquinones (UQ and menaquinones (MK without tedious pretreatment. Supercritical carbon dioxide (scCO2 extraction with the solid-phase cartridge trap proved to be a more effective and rapid method for extracting respiratory quinones, compared to a conventional organic solvent extraction method. This methodology leads to a successful analytical procedure that involves a significant reduction in the complexity and sample preparation time. Application of the optimized methodology to characterize microbial communities based on the RQ profile was demonstrated for a variety of environmental samples (activated sludge, digested sludge, and compost and biological samples (swine and Japanese quail feces.

  19. Geochemistry of pore-fluids related to the distribution of the biological communities on the giant Regab pockmark, off Gabon

    Science.gov (United States)

    de Prunelé, A.; Caprais, J.; Ruffine, L.; Cassarino, L.; Guyader, V.; Bollinger, C.; Ondréas, H.; Donval, J.; Olu, K.; Geli, L. B.; Cunningham, K. L.; Cauquil, E.

    2013-12-01

    The Regab pockmark is a giant structure located at 3200 m water depth offshore Gabon and ~ 10 km north to the deep Congo channel (Zaïre canyon) (Gay et al. 2006; Ondréas et al. 2005). It has been visited for the first time in 2000 during the Zairov cruise. Since that time, several scientific cruises have allowed further investigations of this pockmark. The last cruise, WACS, for West Africa Cold Seeps, in January- February 2010, was undertaken on board the R/V ';Pourquoi Pas?' with the aim of identifying changes which can occur over time on this pockmark. Besides intensive ROV dives, three calypso cores and several push cores have been collected to better understand the relationships between the distribution of the living communities and the pore-fluids chemistry. In two calypso cores one collected within the pockmark and one outside, and both in areas without visible biological communities, pore-fluids profiles of dissolved elements (Alk, SO42-, Mn2+, Fe2+) show that degradation of organic matter is occurring and likely plays an important role in the sulfate reduction (Froelich et al. 1979). Methane was not detected. The Analysis of the pore-fluids by Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC-MS) has shown the presence of alcohols, acid and phenol. These molecules are likely related to the degradation of organic matter and/or the production of the biological communities. Further investigations are ongoing to provide us with a clearer picture regarding the source of these molecules. The third calypso core collected in the northeast part of the pockmark containing gas hydrates. Sulfate profiles from the push cores show significant difference from one community to another. The analyses of both major and minor dissolved elements, along with molecular and isotopic methane concentration measurements are in progress for the push cores. The latter was done using a new analyzer G2201-i from Picarro for which new methods applied to pore-fluids has

  20. Enantioselective separation of biologically active basic compounds in ultra-performance supercritical fluid chromatography.

    Science.gov (United States)

    Geryk, Radim; Kalíková, Květa; Schmid, Martin G; Tesařová, Eva

    2016-08-17

    The enantioseparation of basic compounds represent a challenging task in modern SFC. Therefore this work is focused on development and optimization of fast SFC methods suitable for enantioseparation of 27 biologically active basic compounds of various structures. The influences of the co-solvent type as well as different mobile phase additives on retention, enantioselectivity and enantioresolution were investigated. Obtained results confirmed that the mobile phase additives, especially bases (or the mixture of base and acid), improve peak shape and enhance enantioresolution. The best results were achieved with isopropylamine or the mixture of isopropylamine and trifluoroacetic acid as additives. In addition, the effect of temperature and back pressure were evaluated to optimize the enantioseparation process. The immobilized amylose-based chiral stationary phase, i.e. tris(3,5-dimethylphenylcarbamate) derivative of amylose proved to be useful tool for the enantioseparation of a broad spectrum of chiral bases. The chromatographic conditions that yielded baseline enantioseparations of all tested compounds were discovered. The presented work can serve as a guide for simplifying the method development for enantioseparation of basic racemates in SFC. PMID:27286774

  1. No biological evidence of XMRV in blood or prostatic fluid from prostate cancer patients.

    Directory of Open Access Journals (Sweden)

    Ramon Mendoza

    Full Text Available BACKGROUND: XMRV (xenotropic murine leukemia virus-related virus was initially discovered in association with prostate cancer and later with chronic fatigue syndrome (CFS. Its association with CFS is now largely discredited, and current results support a laboratory origin for XMRV with no reproducible evidence for infection of humans. However, some results indicating the presence of XMRV in prostate cancer are difficult to attribute to sample contamination. Here we have sought biological evidence that might confirm the presence of XMRV in prostate cancer samples previously having tested positive. METHODS AND RESULTS: We have tested for infectious XMRV and neutralizing antibodies against XMRV in blood plasma from 29 subjects with prostate cancer, and for infectious XMRV in prostate secretions from another five prostate cancer subjects. Nine of these subjects had previously tested positive for XMRV by PCR or by virus assay. We did not detect XMRV or related retroviruses in any sample, and the neutralizing activities of the plasma samples were all very low, a result inconsistent with XMRV infection of the plasma donors. CONCLUSIONS: We find no evidence for XMRV infection of any human subject tested, either by assay for infectious virus or for neutralizing antibodies. Our results are consistent with the majority of published studies on XMRV, which find that XMRV is not present in humans. The observed low to undetectable XMRV neutralization by human plasma indicates a lack of innate restriction of XMRV replication by soluble factors in human blood.

  2. The two coupling fluids method for ultrasonic velocity measurement. Application to biological tissues

    International Nuclear Information System (INIS)

    Measuring the ultrasonic velocity in soft materials, especially in biological tissues, is never easy. One of the main issues is that the thickness of the sample under test is badly defined. From the time-of-flight measurement method, uncertainties in the thickness induce important uncertainties in experimental results. This implies that the ultrasonic velocity is often a poor criterion when it could be a good one. This paper introduces a new method to measure the ultrasonic velocity in soft materials without knowing the sample thickness The main idea of this method is to use two different coupling media to make two relative time-of-flight measurements. The comparison of these two measurements gives the ultrasonic velocity in the sample under test. Furthermore, this comparison can give the local thickness of the sample. The uncertainty calculations show that the effect on the thickness is drastically reduced by using this new ultrasound method. This method is validated on a reference sample (silicone). Before conclusion, some experimental results obtained with mouse skin samples are presented

  3. Wine as a biological fluid: history, production, and role in disease prevention.

    Science.gov (United States)

    Soleas, G J; Diamandis, E P; Goldberg, D M

    1997-01-01

    Wine has been part of human culture for 6,000 years, serving dietary and socio-religious functions. Its production takes place on every continent, and its chemical composition is profoundly influenced by enological techniques, the grape cultivar from which it originates, and climatic factors. In addition to ethanol, which in moderate consumption can reduce mortality from coronary heart disease by increasing high-density lipoprotein cholesterol and inhibiting platelet aggregation, wine (especially red wine) contains a range of polyphenols that have desirable biological properties. These include the phenolic acids (p-coumaric, cinnamic, caffeic, gentisic, ferulic, and vanillic acids), trihydroxy stilbenes (resveratrol and polydatin), and flavonoids (catechin, epicatechin, and quercetin). They are synthesized by a common pathway from phenylalanine involving polyketide condensation reactions. Metabolic regulation is provided by competition between resveratrol synthase and chalcone synthase for a common precursor pool of acyl-CoA derivatives. Polymeric aggregation gives rise, in turn to the viniferins (potent antifungal agents) and procyanidins (strong antioxidants that also inhibit platelet aggregation). The antioxidant effects of red wine and of its major polyphenols have been demonstrated in many experimental systems spanning the range from in vitro studies (human low-density lipoprotein, liposomes, macrophages, cultured cells) to investigations in healthy human subjects. Several of these compounds (notably catechin, quercetin, and resveratrol) promote nitric oxide production by vascular endothelium; inhibit the synthesis of thromboxane in platelets and leukotriene in neutrophils, modulate the synthesis and secretion of lipoproteins in whole animals and human cell lines, and arrest tumour growth as well as inhibit carcinogenesis in different experimental models. Target mechanisms to account for these effects include inhibition of phospholipase A2 and cyclo

  4. Determination of cyclodextrins in biological fluids by high-performance liquid chromatography with negative colorimetric detection using post-column complexation with phenolphthalein

    NARCIS (Netherlands)

    Frijlink, H.W.; Visser, J.; Drenth, B.F.H.

    1987-01-01

    A rapid and sensitive high-performance liquid chromatographic method for the analysis of beta- and gamma-cyclodextrin in aqueous biological fluids such as plasma, urine, or tissue homogenate is described. The chromatographic system consists of a microBondapak Phenyl column as stationary phase and a

  5. High-throughput analysis of drugs in biological fluids by desorption electrospray ionization mass spectrometry coupled with thin liquid membrane extraction

    DEFF Research Database (Denmark)

    Rosting, Cecilie; Pedersen-Bjergaard, Stig; Hansen, Steen Honore';

    2013-01-01

    Biological fluids such as urine, saliva and whole blood were analyzed for contents of drugs by a new combination of desorption electrospray ionization mass spectrometry (DESI-MS) and thin liquid membrane extraction (TLME). Analytes from the sample were extracted into a thin liquid membrane...

  6. Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry.

    Science.gov (United States)

    Gomes, Fabio P; Shaw, P Nicholas; Hewavitharana, Amitha K

    2016-01-15

    The determination of both the water-soluble and lipid-soluble vitamin D compounds in human biological fluids is necessary to illuminate potentially significant biochemical mechanisms. The lack of analytical methods to quantify the water-soluble forms precludes studies on their role and biological functions; currently available liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods are able to determine only a single sulfated form of Vitamin D. We describe here a highly sensitive and specific LC-MS/MS method for the quantification of four sulfated forms of vitamin D: vitamins D2- and D3-sulfate (D2-S and D3-S) and 25-hydroxyvitamin D2- and D3-sulfate (25(OH)D2-S and 25(OH)D3-S). A comparative evaluation showed that the ionization efficiencies of underivatized forms in negative ion mode electrospray ionisation (ESI) are superior to those of the derivatized (using 4-phenyl-l,2,4-triazoline-3,5-dione (PTAD)) forms in positive ion mode ESI. Separation was optimised to minimise co-elution with endogenous matrix compounds, thereby reducing ion suppression/enhancement effects. Isotopically labelled analogues of each compound were used as internal standards to correct for ion suppression/enhancement effects. The method was validated and then applied for the analysis of breastmilk and human serum. The detection limits, repeatability standard deviations, and recoveries ranged from 0.20 to 0.28fmol, 2.8 to 10.2%, and 81.1 to 102%, respectively. PMID:26708628

  7. Pilot Scale Test to Treat High Concentration Gasification Wastewater Using Catalytic Oxidation and Aerobic Biological Fluid-Bed Combination Process

    Institute of Scientific and Technical Information of China (English)

    LI Na; HUANG Jun-li; WANG Wei; ZHAO Jian-wei; WANG Cui-lin; CUI Chong-wei

    2008-01-01

    The gasitication wastewatet is a kind of typical ocgauic industrial wastewatet with high chemical oxygen demand (COD) and ammonia uitrogen,which could not be completely degraded by the traditional physical,chimical and bidogical method.So it is very important to find an effective treatment process.A combination process of catalytic oxidation with noble metal catalysts and aerobic biological fluid-bed packed with the new uitrastructure biological carriers,which was devdoped by ourselves,was investigated to treat the gasification wastcwater.The pilot scale test with 0.5m3/h influent flow was carried out to investigate the performance of this new combination process.The results showed that the effluent COD was 84.02 mg/L,ananonia nitrogen was 14.15 mg/L,and total phenol was 0.20 mg/L,which could completely meet the Grade I of Wastewater Discharge Standard (GB8978-1996),when the influent average COD was 5564 mg/L,anunonia nitrogen was 237 mg/L,and total phenol was 1100 mg/L.The two catalytic reactors could evidently improve the wastewater biodegradability,and the value of BOD5/COD(B/C) increased from 0.23 to 0.413 in the one-stage catalytic reactor and from 0.273 to 0.421 in two-stage catalytic reactor.The further experiment results showed that the effluent quality of this new combination progess could still meet the discharge standard,aromatic and heterocyclic compounds were degraded effectively in this combination process.

  8. The forward undulatory locomotion of Ceanorhabditis elegans in viscoelastic fluids

    Science.gov (United States)

    Shen, Amy; Ulrich, Xialing

    2013-11-01

    Caenorhabditis elegans is a soil dwelling roundworm that has served as model organisms for studying a multitude of biological and engineering phenomena. We study the undulatory locomotion of nematode in viscoelastic fluids with zero-shear viscosity varying from 0.03-75 Pa .s and relaxation times ranging from 0-350 s. We observe that the averaged normalized wavelength of swimming worm is essentially the same as that in Newtonian fluids. The undulatory frequency f shows the same reduction rate with respect to zero-shear viscosity in viscoelastic fluids as that found in the Newtonian fluids, meaning that the undulatory frequency is mainly controlled by the fluid viscosity. However, the moving speed Vm of the worm shows more distinct dependence on the elasticity of the fluid and exhibits a 4% drop with each 10-fold increase of the Deborah number De, a dimensionless number characterizing the elasticity of a fluid. To estimate the swimming efficiency coefficient and the ratio K =CN /CL of resistive coefficients of the worm in various viscoelastic fluids, we show that whereas it would take the worm around 7 periods to move a body length in a Newtonian fluid, it would take 27 periods to move a body length in a highly viscoelastic fluid.

  9. Move up,Move out

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2007-01-01

    @@ China has already become the world's largest manufacturer of cement,copper and steel.Chinese producers have moved onto the world stage and dominated the global consumer market from textiles to electronics with amazing speed and efficiency.

  10. Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids.

    Science.gov (United States)

    Khaled, Elmorsy; Kamel, Manal S; Hassan, Hassan N; Abd El-Alim, Sameh H; Aboul-Enein, Hassan Y

    2012-12-01

    Miniaturized potentiometric sensors based on β-cyclodextrins (β-CDs) are described for determination of metformin (Mf) in pharmaceutical preparations and biological fluids. Electrode matrix compositions are optimized on the basis of the nature and content of sensing ionophore, ionic sites and plasticizers. Coated wire electrodes (CWEs) modified with heptakis(2,3,6-tri-O-methyl)-β-CD, sodium tetrakis(4-fluorophenyl)borate (NaTFPB) and 2-fluorophenyl 2-nitrophenyl ether (f-NPE), work satisfactorily in the concentration range from 10(-6) to 10(-1) mol L(-1) with Nernstian compliance (55.7 ± 0.4 mV per decade activity) and a detection limit of 8 × 10(-7) mol L(-1). Incorporation of β-CD as a molecular recognition element improved the electrode sensitivity and selectivity due to encapsulation of Mf into the β-CD cavity (host-guest interaction). The developed electrodes have been successfully applied for the potentiometric determination of Mf under batch and flow injection analysis (FIA). FIA allows analysis of 90 samples per h offering the advantages of simplicity, accuracy and automation feasibility. The dissolution profile for metformin pharmaceutical samples (Cidophage®) was monitored using the proposed electrode in comparison with the official spectrophotometric methods. Characterization of the formed Mf-β-CD inclusion complexes is discussed in detail.

  11. Electrochemical oxidation behavior of hydrochlorothiazide on a glassy carbon electrode and its voltammetric determination in pharmaceutical formulations and biological fluids

    Directory of Open Access Journals (Sweden)

    Ali F. Alghamdi

    2014-09-01

    Full Text Available The electrochemical oxidation behavior of hydrochlorothiazide (HCT on a glassy carbon as a working electrode was investigated in Britton–Robinson (B–R buffer pH 3, by using anodic stripping voltammetry (ASV and cyclic voltammetry (CV. This drug gave a well-defined voltammetric oxidation peak at + 1200 mV versus an Ag/AgCl reference electrode. The electrochemical oxidation process was shown to be irreversible and diffusion controlled, with adsorption characterized over the entire pH range. The optimized conditions, such as accumulation time and potential, scan rate, frequency, pulse amplitude, varying of working electrodes, and instrumental parameters were studied. The calibration graph for HCT was obtained from 4 × 10−6 to 4 × 10−5 M (correlation coefficient = 0.997 using the developed electroanalytical method (ASV. The detection limit of this drug was 4.3 × 10−9 M. ASV and CV techniques with adequate precision and accuracy have been developed and applied for direct determination of HCT in commercial tablets without separation or extraction procedures and biological fluids such as urine and plasma.

  12. Spectrofluorimetric method for quantification of citalopram in pharmaceutical preparations and biological fluids through oxidation with Ce(IV)

    Science.gov (United States)

    Shah, Jasmin; Jan, M. Rasul; Khan, M. Naeem; Inayatullah

    2013-01-01

    A sensitive and simple spectrofluorimetric method for the quantification of citalopram in a pure form, in pharmaceutical preparations, and in human blood plasma and urine has been described. The proposed method was based on the oxidation of citalopram by Ce(IV) in acidic media to produce fluorescent Ce(III), and on the subsequent measurement of its fluorescence intensity at 353 nm after excitation at 252 nm. All variables affecting the oxidation of citalopram such as Ce(IV) concentration, the type and concentration of acid, temperature and heating time were studied and optimized. Under the optimized experimental conditions the linear range of concentration versus fluorescence intensity was found to lie between 0.02 and 1.4 g/ml. Limits of detection and quantification were determined to be 6.9·10-3 g/ml and 2.3·10-2 g/ml respectively. Effects of excipients commonly used in the quantification of citalopram have been studied and no interferences were found. The proposed method was successfully applied to determine citalopram in pure form, in pharmaceutical preparations, and in biological fluids. Good recoveries in the ranges of 95.31-101.67%, 88.50-96.67%, and 90.0-96.67% were obtained for the pharmaceutical preparations (tablets), blood plasma, and human urine respectively.

  13. Theory of locomotion through complex fluids

    CERN Document Server

    Elfring, Gwynn

    2014-01-01

    Microorganisms such as bacteria often swim in fluid environments that cannot be classified as Newtonian. Many biological fluids contain polymers or other heterogeneities which may yield complex rheology. For a given set of boundary conditions on a moving organism, flows can be substantially different in complex fluids, while non-Newtonian stresses can alter the gait of the microorganisms themselves. Heterogeneities in the fluid may also be characterized by length scales on the order of the organism itself leading to additional dynamic complexity. In this chapter we present a theoretical overview of small-scale locomotion in complex fluids with a focus on recent efforts quantifying the impact of non-Newtonian rheology on swimming microorganisms.

  14. Micropropulsion and microrheology in complex fluids via symmetry breaking

    CERN Document Server

    Pak, On Shun; Brandt, Luca; Lauga, Eric; 10.1063/1.4758811

    2013-01-01

    Many biological fluids have polymeric microstructures and display non-Newtonian rheology. We take advantage of such nonlinear fluid behavior and combine it with geometrical symmetry-breaking to design a novel small-scale propeller able to move only in complex fluids. Its propulsion characteristics are explored numerically in an Oldroyd-B fluid for finite Deborah numbers while the small Deborah number limit is investigated analytically using a second-order fluid model. We then derive expressions relating the propulsion speed to the rheological properties of the complex fluid, allowing thus to infer the normal stress coefficients in the fluid from the locomotion of the propeller. Our simple mechanism can therefore be used either as a non-Newtonian micro-propeller or as a micro-rheometer.

  15. MULTI-ANALYTE DETECTION FOR BIOLOGICAL FLUIDS Towards Continous Monitoring of Glucose, Ionized Calcium and pH using a Viscometric Affinity Biosensor

    OpenAIRE

    Boss, Christophe; Meurville, Eric; Ryser, Peter; Schmitt, Frédéric; Juillerat-Jeanneret, Lucienne; Dosil-Rosende, Pablo; De Souza, Desdemona

    2011-01-01

    We present a viscometric affinity biosensor that can potentially allow continuous multi-analyte monitoring in biological fluids like blood or plasma. The sensing principle is based on the detection of viscosity changes of a polymeric solution which has a selective affinity for the analyte of interest. The chemico-mechanical sensor incorporates an actuating piezoelectric diaphragm, a sensing piezoelectric diaphragm and a flow-resisting microchannel for viscosity detection. A free-standing Anod...

  16. Engineering fluid flow using sequenced microstructures

    Science.gov (United States)

    Amini, Hamed; Sollier, Elodie; Masaeli, Mahdokht; Xie, Yu; Ganapathysubramanian, Baskar; Stone, Howard A.; di Carlo, Dino

    2013-05-01

    Controlling the shape of fluid streams is important across scales: from industrial processing to control of biomolecular interactions. Previous approaches to control fluid streams have focused mainly on creating chaotic flows to enhance mixing. Here we develop an approach to apply order using sequences of fluid transformations rather than enhancing chaos. We investigate the inertial flow deformations around a library of single cylindrical pillars within a microfluidic channel and assemble these net fluid transformations to engineer fluid streams. As these transformations provide a deterministic mapping of fluid elements from upstream to downstream of a pillar, we can sequentially arrange pillars to apply the associated nested maps and, therefore, create complex fluid structures without additional numerical simulation. To show the range of capabilities, we present sequences that sculpt the cross-sectional shape of a stream into complex geometries, move and split a fluid stream, perform solution exchange and achieve particle separation. A general strategy to engineer fluid streams into a broad class of defined configurations in which the complexity of the nonlinear equations of fluid motion are abstracted from the user is a first step to programming streams of any desired shape, which would be useful for biological, chemical and materials automation.

  17. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  18. Restricted access magnetic materials prepared by dual surface modification for selective extraction of therapeutic drugs from biological fluids

    Energy Technology Data Exchange (ETDEWEB)

    Wang Yu; Wang Yuxia; Chen Lei [School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072 (China); Wan Qianhong, E-mail: qhwan@tju.edu.cn [School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072 (China)

    2012-02-15

    Magnetic porous particles with dual functionality have been prepared by a two-step procedure and evaluated as novel restricted access materials for extraction of therapeutic agents from biological fluids. The magnetic silica particles served as scaffolds were first modified with diol groups, which were then converted to octadecyl esters through reaction with stearoyl chloride. In the second step, the octadecyl esters on the exterior surface were hydrolyzed by the action of lipase to yield magnetic particles with hydrophobic reversed-phase ligands on the inner surface and biocompatible diol groups on the outer surface. The restricted access behavior of the resulting materials was confirmed by differential binding of small molecules such as methotrexate (MTX), leucovorin (LV) and folic acid (FA) relative to bovine serum albumin. While MTX, LV and FA were all bound to the magnetic particles with high affinity, the adsorption of the protein was markedly reduced due to size exclusion effect. The utility of the magnetic particles for sample preparation was tested in solid-phase extraction of MTX, LV and FA from spiked human serum and the effects of the SPE conditions on the recovery of the analytes were systematically studied. Moreover, the magnetic particle-based sample preparation procedure coupled with reversed-phase liquid chromatography analysis was validated in terms of specificity, linearity and reproducibility. The method was shown to be free from interference of endogenous compounds and linear over the concentration range of 0.5-10 {mu}g/mL for the three drugs studied. The limits of detection for the three drugs in serum were in the range of 0.160-0.302 {mu}g/mL. Reproducibility expressed as the RSD of the recovery for ten replicated extractions at three different concentrations was found to be less than 8.93%. With a unique combination of surface functionality with magnetic cores, the restricted access magnetic particles may be adapted in automated and high

  19. Laser Doppler instrument measures fluid velocity without reference beam

    Science.gov (United States)

    Bourquin, K. R.; Shigemoto, F. H.

    1971-01-01

    Fluid velocity is measured by focusing laser beam on moving fluid and measuring Doppler shift in frequency which results when radiation is scattered by particles either originally present or deliberately injected into moving fluid.

  20. An ultra-micro method for the determination of total nitrogen in biological fluids based on Kjeldahl digestion and enzymatic estimation of ammonia.

    Science.gov (United States)

    Smit, E M

    1979-06-01

    An ultra-micro method for the determination of the total nitrogen-content of biological fluids and suspensions is described, based on a digestion in sulphuric acid and a enzymatic determination of the ammonia formed with glutamate dehydrogenase (EC 1.4.1.3). The proposed method yields the same results as the classical Kjeldahl procedure, but is less time-consuming. The detection-limit of the nitrogen, without loss of precision and accuracy, is much lower than in the original Kjeldahl procedure, and is in the order of 35 ng N per sample.

  1. Dispersion of hydrophobic magnetic nanoparticles using ultarsonic-assisted in combination with coacervative microextraction for the simultaneous preconcentration and determination of tricyclic antidepressant drugs in biological fluids.

    Science.gov (United States)

    Jannesar, Ramin; Zare, Fahimeh; Ghaedi, Mehrorang; Daneshfar, Ali

    2016-09-01

    A two-step sample preparation technique based on dispersive micro solid-phase extraction combined with coacervative microextraction is presented for preconcentration and determination of tricyclic antidepressant drugs in biological samples. An important feature of the method is the application of hydrophobic magnetic nanoparticles, which in combination with coacervative microextraction method enables development of rapid and efficient extraction procedure in order to achievement of a high extraction efficiency. Simultaneous optimization by experimental design lead to improvement of method with low cost which supply useful information about interaction among variables. Under the optimized conditions, a linear range of 5-1000ngmL(-1) with detection limits from 0.51 to 1.4ngmL(-1) were obtained for target analytes. The method was successfully used for the determination of analytes in biological fluids (plasma and urine) with relative recoveries in the range of 89-105% (RSDs<3.5%). PMID:27150784

  2. Estimation of the Patients' Adaptation to Noble Alloy Dentures Relying on the Parameters of Biological Fluids in Oral Cavities

    Institute of Scientific and Technical Information of China (English)

    LEBEDENKO I. Yu.; PARUNOV V. A.; KITKINA T. B.

    2012-01-01

    For the study of the effect of Plagodent and Palladent noble alloy dentures (OJSC "SIC ‘Supermetal’",Russia),the elemental compositions of the fluids obtained from gingival sulcus of abutment teeth of metal-ceramic dentures with frames made of the above-stated dental alloys,have been investigated.Response of white blood cells and fibroblasts in the gingival fluid and the mixed saliva of the patients a long time after prosthetic repair,relying on the content of proinflammatory interleukins IL-1 β and IL-6,anti-inflammatory interleukins IL-4 and IL-10,the factor of tumor necrosis TNF-α and lactoferrin,has been investigated.The results obtained have convincingly proved the biosafety of the Plagodent and Palladent noble alloys.

  3. Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples.

    Science.gov (United States)

    Ramirez, Daniela Andrea; Locatelli, Daniela Ana; Torres-Palazzolo, Carolina Andrea; Altamirano, Jorgelina Cecilia; Camargo, Alejandra Beatriz

    2017-01-15

    Organosulphur compounds (OSCs) present in garlic (Allium sativum L.) are responsible of several biological properties. Functional foods researches indicate the importance of quantifying these compounds in food matrices and biological fluids. For this purpose, this paper introduces a novel methodology based on dispersive liquid-liquid microextraction (DLLME) coupled to high performance liquid chromatography with ultraviolet detector (HPLC-UV) for the extraction and determination of organosulphur compounds in different matrices. The target analytes were allicin, (E)- and (Z)-ajoene, 2-vinyl-4H-1,2-dithiin (2-VD), diallyl sulphide (DAS) and diallyl disulphide (DADS). The microextraction technique was optimized using an experimental design, and the analytical performance was evaluated under optimum conditions. The desirability function presented an optimal value for 600μL of chloroform as extraction solvent using acetonitrile as dispersant. The method proved to be reliable, precise and accurate. It was successfully applied to determine OSCs in cooked garlic samples as well as blood plasma and digestive fluids. PMID:27542503

  4. Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples.

    Science.gov (United States)

    Ramirez, Daniela Andrea; Locatelli, Daniela Ana; Torres-Palazzolo, Carolina Andrea; Altamirano, Jorgelina Cecilia; Camargo, Alejandra Beatriz

    2017-01-15

    Organosulphur compounds (OSCs) present in garlic (Allium sativum L.) are responsible of several biological properties. Functional foods researches indicate the importance of quantifying these compounds in food matrices and biological fluids. For this purpose, this paper introduces a novel methodology based on dispersive liquid-liquid microextraction (DLLME) coupled to high performance liquid chromatography with ultraviolet detector (HPLC-UV) for the extraction and determination of organosulphur compounds in different matrices. The target analytes were allicin, (E)- and (Z)-ajoene, 2-vinyl-4H-1,2-dithiin (2-VD), diallyl sulphide (DAS) and diallyl disulphide (DADS). The microextraction technique was optimized using an experimental design, and the analytical performance was evaluated under optimum conditions. The desirability function presented an optimal value for 600μL of chloroform as extraction solvent using acetonitrile as dispersant. The method proved to be reliable, precise and accurate. It was successfully applied to determine OSCs in cooked garlic samples as well as blood plasma and digestive fluids.

  5. Deep-sequencing of microRNA associated with Alzheimer’s disease in biological fluids: From biomarker discovery to diagnostic practice

    Directory of Open Access Journals (Sweden)

    Lesley eCheng

    2013-08-01

    Full Text Available Diagnostic tools for neurodegenerative diseases such as Alzheimer's disease (AD currently involve subjective neuropsychological testing and specialised brain imaging techniques. While definitive diagnosis requires a pathological brain evaluation at autopsy, neurodegenerative changes are believed to begin years before the clinical presentation of cognitive decline. Therefore, there is an essential need for reliable biomarkers to aid in the early detection of disease in order to implement preventative strategies. microRNAs (miRNA are small non-coding RNA species that are involved in post-transcriptional gene regulation. Expression levels of miRNA’s have potential as diagnostic biomarkers as they are known to circulate and tissue specific profiles can be identified in a number of bodily fluids such as plasma, CSF and urine. Recent developments in deep sequencing technology present a viable approach to develop biomarker discovery pipelines in order to profile microRNA signatures in bodily fluids specific to neurodegenerative diseases. Here we review the potential use of microRNA deep sequencing in biomarker identification from biological fluids and its translation into clinical practice.

  6. A Coupled Level Set and Volume of Fluid Method for Tracking Moving Interface in Multiphase Flow%基于CLSVOF方法的多介质流运动界面追踪

    Institute of Scientific and Technical Information of China (English)

    陈善群; 廖斌

    2012-01-01

    根据Level-Set方法和VOF方法各自的优缺点,耦合生成一种Level-Set和VOF的耦合界面追踪方法,简称CLSVOF(Coupled Level Set and Volume Of Fluid Method)方法.CLSVOF方法利用Level-Set函数计算VOF体积份额,克服了VOF方法难以准确计算界面的法向量和曲率的缺点;同时又利用VOF体积份额修正Level-Set函数,克服了Level-Set方法在计算过程中有物理量的损失的缺点.用旋转流场和剪切流场的数值算例验证了CLSVOF方法相比VOF方法提高了运动界面追踪的分辨率,相比Level-Set方法实现了计算过程中的物理量守恒.运用CLSVOF方法数值模拟了两个多介质流运动界面算例,分别是自由剪切层问题和气泡在静止水体中上升问题.对比数值模拟结果与理论分析和实验结果可知CLSVOF方法能精确地追踪多介质流运动界面.%Based on the advantages and disadvantages of the Level-Set method and the VOF method,a coupled Level-Set and Volume of Fluid (CLSVOF) method is presented.Through using the Level-Set function to computing volumetric fraction,CLSVOF method overcomes the disadvantage of the VOF method,which is the fact that it is difficult to obtain the normal vector and curvature accurately.Through using the VOF volumetric fraction to revise Level-Set function,CLSVOF method overcomes the drawback of the Level-Set method,which is mass loss in computational process.The numerical results of the applied cases validate that the CLSVOF method improves tracking resolution than the VOF method,as well as,realizes mass conservation compared with the Level-Set method.Furthermore,the CLSVOF method is applied to simulatetwo types of the movement interface in multiphase flow,which are free shear layer and a rising gas bubble in water,respectively.The numerical results are compared with theoretical analysis and experimental data.It is shown that the CLSVOF method can accurately track moving interface in multiphase flow.

  7. Mechanics of moving materials

    CERN Document Server

    Banichuk, Nikolay; Neittaanmäki, Pekka; Saksa, Tytti; Tuovinen, Tero

    2014-01-01

    This book deals with theoretical aspects of modelling the mechanical behaviour of manufacturing, processing, transportation or other systems in which the processed or supporting material is travelling through the system. Examples of such applications include paper making, transmission cables, band saws, printing presses, manufacturing of plastic films and sheets, and extrusion of aluminium foil, textiles and other materials.   The work focuses on out-of-plane dynamics and stability analysis for isotropic and orthotropic travelling elastic and viscoelastic materials, with and without fluid-structure interaction, using analytical and semi-analytical approaches.  Also topics such as fracturing and fatigue are discussed in the context of moving materials. The last part of the book deals with optimization problems involving physical constraints arising from the stability and fatigue analyses, including uncertainties in the parameters.   The book is intended for researchers and specialists in the field, providin...

  8. On the atmosphere of a moving body

    DEFF Research Database (Denmark)

    Pedersen, Johan Rønby; Aref, Hassan

    2010-01-01

    We explore whether a rigid body moving freely with no circulation around it in a two-dimensional ideal fluid can carry a fluid "atmosphere" with it in its motion. Somewhat surprisingly, the answer appears to be "yes." When the body is elongated and the motion is dominated by rotation, we...... demonstrate numerically that, indeed, regions of fluid follow the body in its motion. We see this as an example of the stability of Kolmogorov-Arnold-Moser tori. These observations of an atmosphere around a moving body with no circulation around it appear to be new. (C) 2010 American Institute of Physics...

  9. On the atmosphere of a moving body

    DEFF Research Database (Denmark)

    Pedersen, Johan Rønby; Aref, Hassan

    2010-01-01

    We have explored whether a rigid body moving freely with no circulation around it in a two-dimensional ideal fluid can carry a fluid ``atmosphere'' with it in its motion. Somewhat surprisingly, the answer appears to be ``yes''. When the body is elongated and the motion is dominated by rotation, we...... demonstrate numerically that, indeed, regions of fluid follow the body in its motion. Since there is a double-island structure for the case of pure rotation, as already found by Morton and Darwin many years ago, we see the existence of an atmosphere for the moving body as an example of the stability...

  10. The nanocrystalline coordination polymer of AMT-Ag for an effective detection of ciprofloxacin hydrochloride in pharmaceutical formulation and biological fluid.

    Science.gov (United States)

    Tiwari, Madhu; Kumar, Ashish; Shankar, Uma; Prakash, Rajiv

    2016-11-15

    The present report highlights a cost effective and portable AMT-Ag nanocrystalline coordination polymer (NCCP) based electrochemical sensor for an efficient sensing of biologically active drug molecule ciprofloxacin hydrochloride (CFX). The AMT-Ag NCCP, is synthesized using an easily accessible organic ligand 2-amino-5-mercapto-1,3,4-thiadiazole (AMT) with silver nitrate. In the infinite polymer array of AMT-Ag, silver (I) centers are bridged by tecton AMT through the exocyclic thiol and amino linkage. A successful ultra‒trace detection of CFX has been achieved due to the prominent electron channeling through the pores of polymeric nano-crystallites. The efficient charge transfer arises at the interface of electrolyte and AMT-Ag nano-crystals anchored electrode through hydrophobic interaction and π-π electron coupling. The voltammogram reveals the critical redox features of CFX and provides a clear representation about the steps involved in the AMT-Ag assisted oxidation of CFX. This specific signature further applied in the voltammetric assay of CFX in pharmaceutical formulation (eye drops) and biological fluid (urine) by a significantly high sensitivity (0.002µA/µM and 0.007µA/µM) and detection limit (22nM and 60nM) respectively without any interference. Therefore, the developed AMT-Ag NCCP could serve as a highly valuable platform for the fabrication of high-performance electrochemical sensors for the detection of biologically important drug molecules. PMID:27236138

  11. Effect of Supercritical Fluids on the Biological Activity of Absidia coerulea for the Hydroxylation of Reichsterin's Substance Acetate

    Institute of Scientific and Technical Information of China (English)

    Xiu Feng LIU; Hui Ming ZHU; Tuan Wei ZHANG; Bao Quan ZHANG

    2005-01-01

    The viability and biological activity of Absidia coerulea in compressed or supercritical CO2 and C2H4 were studied. The specific activity ofAbsidia coerulea in 7.5MPa CO2 and C2H4 at 306K can reach to 23% and 75% respectively, leading to the feasibility of using supercritical C2H4as an alternative to the organic solvent in the hydroxylation of Reichsterin's substance acetate.

  12. Application of Moving Bed Biofilm Reactor (MBBR) and Integrated Fixed Activated Sludge (IFAS) for Biological River Water Purification System: A Short Review

    Science.gov (United States)

    Lariyah, M. S.; Mohiyaden, H. A.; Hayder, G.; Hayder, G.; Hussein, A.; Basri, H.; Sabri, A. F.; Noh, MN

    2016-03-01

    This review paper present the MBBR and IFAS technology for urban river water purification including both conventional methods and new emerging technologies. The aim of this paper is to present the MBBR and IFAS technology as an alternative and successful method for treating different kinds of effluents under different condition. There are still current treatment technologies being researched and the outcomes maybe available in a while. The review also includes many relevant researches carried out at the laboratory and pilot scales. This review covers the important processes on MBBR and IFAS basic treatment process, affecting of carrier type and influent types. However, the research concluded so far are compiled herein and reported for the first time to acquire a better perspective and insight on the subject with a view of meeting the news approach. The research concluded so far are compiled herein and reported for the first time to acquire a better perspective and insight on the subject with a view of meeting the news approach. To this end, the most feasible technology could be the combination of advanced biological process (bioreactor systems) including MBBR and IFAS system.

  13. Precolumn derivatization reagents for high-speed analysis of amines and amino acids in biological fluid using liquid chromatography/electrospray ionization tandem mass spectrometry.

    Science.gov (United States)

    Shimbo, Kazutaka; Oonuki, Takashi; Yahashi, Akihisa; Hirayama, Kazuo; Miyano, Hiroshi

    2009-05-01

    A rapid analytical method for amines and amino acids was developed, involving derivatization with the novel reagent 3-aminopyridyl-N-hydroxysuccinimidyl carbamate (APDS), followed by reversed-phase high-performance liquid chromatography and electrospray ionization tandem mass spectrometry (HPLC/ESI-MS/MS). More than 100 different analytes with amino groups, including amino acids in biological fluids such as mammalian plasma, could be measured within 10 min. The analytes were easily derivatized with APDS under the mild conditions. Selective reaction monitoring of ESI-MS/MS in positive mode was carried out to include the transitions of all of the protonated molecular ions of analytes derivatized with APDS to the common fragment at m/z 121, which was derived from the amino pyridyl moiety of the reagent. We evaluated the retention time precision, the quantification limits, the linearity, the intra- and inter-day precisions and the accuracy of 22 typical amino acids found in biological fluids, by analyzing a standard amino acid mixture and rat plasma. The intra-day relative standard deviations (RSDs) of the retention times of the 22 amino acids and their internal standards were within 0.9% and the inter-day RSDs were less than 1.1%, except for asparagines, with an RSD of 1.9%. The intra-day and inter-day RSDs of amino acid analyses in rat plasma were within 8.0% and 4.5%, respectively. The method, which facilitates the amino acid analysis of more than 100 samples in a day, represents an alternative to traditional amino acid analysis techniques, such as chromatography using postcolumn derivatization by ninhydrin. PMID:19350529

  14. A high-throughput method for the simultaneous determination of multiple mycotoxins in human and laboratory animal biological fluids and tissues by PLE and HPLC-MS/MS.

    Science.gov (United States)

    Cao, Xiaoqin; Wu, Shuangchan; Yue, Yuan; Wang, Shi; Wang, Yuting; Tao, Li; Tian, Hui; Xie, Jianmei; Ding, Hong

    2013-12-30

    A high-throughput method for the determination of 28 mycotoxins involving pressurised liquid extraction (PLE) coupled with liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has been optimised and validated for determination in various biological fluids and tissues of human and laboratory animals. High-throughput analysis was achieved using PLE pre-treatment and without the need for any cleanup. The extraction solvent was acetonitrile/water/acetic acid (80/19/1, v/v/v). The static extraction time was 5min. The extraction pressure and temperature were 1500psi and 140°C, respectively. The flush volume was 60%. The limits of detection, which were defined as CCα, varied from 0.01μg/kg (μg/L) to 0.69μg/kg (μg/L). The recoveries of spiked samples from 0.20μg/kg (μg/L) to 2μg/kg (μg/L) ranged from 71% to 100.5% with relative standard deviations of less than 17.5%, except FB1 and FB2 recoveries, which were lower than 60%. The method was successfully applied in real samples, and the data indicate that this technique is a useful analytical method for the determination of mycotoxins from humans and animals. To the best of our knowledge, this method is the first for the large-scale testing of multi-class mycotoxins in all types of biological fluids and tissues that uses PLE and HPLC-MS/MS.

  15. OCT-based three-dimensional, three vector component imaging of cilia-driven fluid flow for developmental biology (Conference Presentation)

    Science.gov (United States)

    Huang, Brendan K.; Zhou, Kevin C.; Gamm, Ute A.; Bhandari, Vineet; Khokha, Mustafa K.; Choma, Michael A.

    2016-03-01

    One critical barrier to the robust study of cilia-driven fluid flow in developmental biology is a lack of methods for acquiring three-dimensional (3D) images of three vector component (3C) measurements of flow velocities. A 3D3C map of cilia-driven fluid flow quantifies the flow speed along three axes (e.g. three Cartesian vector components v_x, v_y, v_z) at each point in 3D space. 3D3C quantification is important because cilia-driven fluid flow is not amenable to simplifying assumptions (e.g. parabolic flow profile. Such quantification may enable systematically detailed characterization of performance using shear force and power dissipation metrics derived from 3D3C flow velocity fields. We report our OCT-based results in developing methods for the 3D3C quantification of cilia-driven flow fields. First, we used custom scan protocols and reconstruction algorithms to synthesize 3D3C flow velocity fields from 2D2C fields generated using correlation-based methods (directional dynamic light scattering and digital particle image velocimetry). Xenopus results include flow driven by ciliated embryo skin and flow driven by ciliated ependymal cells in developing brain ventricles. Second, we developed a new approach to particle tracking velocimetry that generates 2D2.5C (2.5C: v_x,|v_y|,v_z) velocity fields from single-plane 2D image acquisitions. We demonstrated this particle streak velocimetry method in calibrated flow phantoms and in flow driven by ciliated Xenopus embryo skin. Additionally, we have preliminary results extending particle streak velocimetry to 3D3C in calibrated flow phantoms with ongoing work in Xenopus embryos.

  16. Active colloids in complex fluids

    CERN Document Server

    Patteson, Alison E; Arratia, Paulo E

    2016-01-01

    We review recent work on active colloids or swimmers, such as self-propelled microorganisms, phoretic colloidal particles, and artificial micro-robotic systems, moving in fluid-like environments. These environments can be water-like and Newtonian but can frequently contain macromolecules, flexible polymers, soft cells, or hard particles, which impart complex, nonlinear rheological features to the fluid. While significant progress has been made on understanding how active colloids move and interact in Newtonian fluids, little is known on how active colloids behave in complex and non-Newtonian fluids. An emerging literature is starting to show how fluid rheology can dramatically change the gaits and speeds of individual swimmers. Simultaneously, a moving swimmer induces time dependent, three dimensional fluid flows, that can modify the medium (fluid) rheological properties. This two-way, non-linear coupling at microscopic scales has profound implications at meso- and macro-scales: steady state suspension proper...

  17. Fullerene-C60-MWCNT composite film based ultrasensitive electrochemical sensing platform for the trace analysis of pyruvic acid in biological fluids.

    Science.gov (United States)

    Brahman, Pradeep Kumar; Pandey, Nidhi; Topkaya, Seda Nur; Singhai, Rashmi

    2015-03-01

    We propose development of a novel electrochemical sensor based on fullerene-multi-walled carbon nanotubes composite film for the sensitive determination of the pyruvic acid in biological fluids. The developed sensor was characterized by cyclic voltammetry. The nanocomposite film of C60-MWCNTs on GCE exhibits electrocatalytic activity towards pyruvic acid reduction and also decreases the reduction overpotential. The influence of the optimization parameters such as pH and effect of loading of composite mixture of C60 and MWCNTs on the electrochemical performance of the sensor were evaluated. Various kinetic parameters such as electron transfer number (n=2), proton transfer number (m=2) and charge transfer coefficient (α=0.56) were also calculated. Under optimized conditions, the squarewave reduction peak current was linear over the concentration range of 2.0-55 nM with the detection and quantification limit of 0.1 nM and 0.8 nM respectively. The fabricated sensor was successfully applied to the detection of pyruvic acid in biological samples with good recovery ranging from 97.6% to 103.6%. PMID:25618707

  18. STUDY ON APPLICATION OF AERATION BIOLOGICAL FLUID TANK TECHNOLGY IN NH+4-N WASTE WATER TREATMENT%曝气生物流化池(ABFT)技术在含氨氮污水治理的应用研究

    Institute of Scientific and Technical Information of China (English)

    陈怡; 卢建国

    2003-01-01

    This paper introduces an application of "Aeration biological fluid tank" technology (ABFT) for the treatment of waste water containing NH+4-N and high concentrated organic chemicals. Highlights were focused on the effects of dissolved oxygen, pH, temperature and retention time on waste water biological treatment in order to find out a new approach in treatment of waste water containing high concentrated NH+4-N.

  19. Flow—injection Chemiluminescence Determination of Reserpine in Medicine and Biological Fluids with Controlled—Reagent—Release Technology

    Institute of Scientific and Technical Information of China (English)

    宋正华; 张尼

    2003-01-01

    A sensitive and rapid chemiluminescence(CL) flow injection with controlled-reagent-release technology for the determination of reserpine was proposed.The Cl reagents,luminol and dichromate,uses in this sensor,were all immobilized on anion-exchange resin.Through injection of 100μl of water,the reagents on the anion-ex-change resin column were eluted and in the presence of reserpine ,the CL intensity was decreased,by which reserpine could be sensed.Reserpine was quantified by measuring the decrement of CL intensity,which was observed linear with the logrithm of reserpine concentration in the rage of 1.0-500.0ng/mL,and the limit of detection was 0.4ng/mL(3σ)with a relative standard deviation of less than 3.0?The proposed procedure was applied in the assay of reserpine in pharmaceutical preparation and biological fhuids without any pre-treatment process and with sampling frequencies of 72 times per hour.

  20. The moving mesh code Shadowfax

    CERN Document Server

    Vandenbroucke, Bert

    2016-01-01

    We introduce the moving mesh code Shadowfax, which can be used to evolve a mixture of gas, subject to the laws of hydrodynamics and gravity, and any collisionless fluid only subject to gravity, such as cold dark matter or stars. The code is written in C++ and its source code is made available to the scientific community under the GNU Affero General Public License. We outline the algorithm and the design of our implementation, and demonstrate its validity through the results of a set of basic test problems, which are also part of the public version. We also compare Shadowfax with a number of other publicly available codes using different hydrodynamical integration schemes, illustrating the advantages and disadvantages of the moving mesh technique.

  1. The moving mesh code SHADOWFAX

    Science.gov (United States)

    Vandenbroucke, B.; De Rijcke, S.

    2016-07-01

    We introduce the moving mesh code SHADOWFAX, which can be used to evolve a mixture of gas, subject to the laws of hydrodynamics and gravity, and any collisionless fluid only subject to gravity, such as cold dark matter or stars. The code is written in C++ and its source code is made available to the scientific community under the GNU Affero General Public Licence. We outline the algorithm and the design of our implementation, and demonstrate its validity through the results of a set of basic test problems, which are also part of the public version. We also compare SHADOWFAX with a number of other publicly available codes using different hydrodynamical integration schemes, illustrating the advantages and disadvantages of the moving mesh technique.

  2. Is the fluid mosaic (and the accompanying raft hypothesis a suitable model to describe fundamental features of biological membranes? What may be missing?

    Directory of Open Access Journals (Sweden)

    Luis Alberto Bagatolli

    2013-11-01

    Full Text Available The structure, dynamics, and stability of lipid bilayers are controlled by thermodynamic forces, leading to overall tensionless membranes with a distinct lateral organization and a conspicuous lateral pressure profile. Bilayers are also subject to built-in curvature-stress instabilities that may be released locally or globally in terms of morphological changes leading to the formation of non-lamellar and curved structures. A key controller of the bilayer’s propensity to form curved structures is the average molecular shape of the different lipid molecules. Via the curvature stress, molecular shape mediates a coupling to membrane-protein function and provides a set of physical mechanisms for formation of lipid domains and laterally differentiated regions in the plane of the membrane. Unfortunately, these relevant physical features of membranes are often ignored in the most popular models for biological membranes. Results from a number of experimental and theoretical studies emphasize the significance of these fundamental physical properties and call for a refinement of the fluid mosaic model (and the accompanying raft hypothesis.

  3. Gold nanoparticles decorated poly-melamine modified glassy carbon sensor for the voltammetric estimation of domperidone in pharmaceuticals and biological fluids.

    Science.gov (United States)

    Rosy; Goyal, Rajendra N

    2015-08-15

    The electrochemical response of an unmodified glassy carbon (GCE), poly-melamine/GCE and gold nanoparticle (AuNP)/poly-melamine/GCE is compared in the present protocol for the sensitive and selective determination of domperidone (DOM). The AuNPs were synthesized in the laboratory and characterized using UV-visible spectroscopy and Transmission Electron Microscopy (TEM). Melamine was electropolymerized onto the glassy carbon surface using cyclic voltammetry and was investigated using Field Emission Scanning Electron Microscopy (FE-SEM) and Electrochemical Impedance Spectroscopy (EIS). The AuNP/poly-melamine/GCE exhibited the best electrochemical response among the three electrodes for the electro-oxidation of DOM, that was inferred from the EIS, cyclic and square wave voltammetry. The modified sensor showed a sensitive, stable and linear response in the concentration range of 0.05-100µM with a detection limit of 6nM. The selectivity of the proposed sensor was assessed in the presence of high concentration of major interfering molecules as xanthine, hypoxanthine, and uric acid. The analytical application of the sensor for the quantification of DOM in pharmaceutical formulations and biological fluids as urine and serum was also investigated and the results demonstrated a recovery of >95% with R.S.D of <5%. PMID:25966380

  4. A poroelastic immersed boundary method with applications to cell biology

    Science.gov (United States)

    Strychalski, Wanda; Copos, Calina A.; Lewis, Owen L.; Guy, Robert D.

    2015-02-01

    The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In the traditional immersed boundary method, the fluid and structure move with the same velocity field. In this work, a model based on the immersed boundary method is presented for simulating poroelastic media in which the fluid permeates a porous, elastic structure of small volume fraction that moves with its own velocity field. Two distinct methods for calculating elastic stresses are presented and compared. The methods are validated on a radially symmetric test problem by comparing with a finite difference solution of the classical equations of poroelasticity. Finally, two applications of the modeling framework to cell biology are provided: cellular blebbing and cell crawling. It is shown that in both examples, poroelastic effects are necessary to explain the relevant mechanics.

  5. [Sodium determination in biological fluids].

    Science.gov (United States)

    Cristol, J-P; Balint, B; Canaud, B; Daurés, M-F

    2007-09-01

    Electrolyte disorders are frequently observed in nephrology and intensive care unit department and Na determination is routinely performed in biochemistry laboratories. Three methods are currently available. Flame photometry remains the reference method. With this method the serum sample is diluted before the actual measurement is obtained. Results are expressed as molarity (per Liter of plasma). Potentiometric methods have an increasing importance due to the advances in ion sensitive (selective) electrodes (ISE). Whereas the instruments for routine chemical analysis typically use indirect potentiometry (involving te dilution of samples) to measure sodium levels, the equipment for measuring arterial blood gases use direct potentiometry without any dilution. Thus, results obtained with indirect potentiometry are expressed in molarity (per liter of plasma) while results obtained with direct potentiometry are initially given in morality (per kg of plasma water) then converted in molarity. Analytical performances are in all cases satisfactory and therefore all the methods could be used in both normal and pathological ranges. Methods involving sample dilution such as flame photometry or indirect potentiometry, the serum sodium value would be expected to be low in case of decrease plasma water (pseudohyponatremia). By contrast, with direct potentiometry where no sample dilution takes place, no interference would be expected since the activity of sodium in the water phase only is being measured. Thus, the classical pseudohyponatremia observed with hyperlipemia or paraproteinemia are not further observed with direct potentiometry. These differences in methodology should be taken into account to explain discrepancies between results obtained with classical biochemistry analyser and with blood gas apparatus.

  6. [To the question of the optimization of methods for detection of vinyl chloride and 1,2-dichloroethane, and their metabolites in biological fluids in workers involved in production of polyvinyl chloride].

    Science.gov (United States)

    Zhurba, O M; Alekseenko, A N

    2014-01-01

    There is considered the improvement of methodological approaches to the gas chromatographic methods- of the detection of vinyl chloride and 1,2-dichloroethane and their metabolites--chloroethanol and monochloroacetic acid in biological fluids. There were evaluated such metrological characteristics of methods, as repeatability, interlaboratoty precision, relevance and accuracy. The value of relative expanded uncertainty does not exceed 30%. There are reported optimal regimes of gas chromatographic analysis, conditions for sample preparation. The results of the contents ofthese chemical compounds and their metabolites in biological fluids from persons working in contact with chlorinated hydrocarbons are presented These techniques can be used for the detection ofthe fact of exposure to toxic substances, assessment of the level of exposure and biomonitoring.

  7. Moving-Frame Approach to Nonlinear Internal Waves in Oceans

    CERN Document Server

    Xu, Xiaoping

    2013-01-01

    In this article, we introduce a moving-frame approach to the geophysical equation of two-dimensional uniformly stratified rotational fluid in oceans and find a family of exact solutions containing ten arbitrary parameter functions.

  8. Moving Target Defense

    CERN Document Server

    Jajodia, Sushil; Swarup, Vipin; Wang, Cliff; Wang, X Sean

    2011-01-01

    Moving Target Defense: Creating Asymmetric Uncertainty for Cyber Threats was developed by a group of leading researchers. It describes the fundamental challenges facing the research community and identifies new promising solution paths. Moving Target Defense which is motivated by the asymmetric costs borne by cyber defenders takes an advantage afforded to attackers and reverses it to advantage defenders. Moving Target Defense is enabled by technical trends in recent years, including virtualization and workload migration on commodity systems, widespread and redundant network connectivity, instr

  9. Fluid Flow at Branching Junctions

    OpenAIRE

    Sochi, Taha

    2013-01-01

    The flow of fluids at branching junctions plays important kinematic and dynamic roles in most biological and industrial flow systems. The present paper highlights some key issues related to the flow of fluids at these junctions with special emphasis on the biological flow networks particularly blood transportation vasculature.

  10. Fluid transport due to nonlinear fluid-structure interaction

    Energy Technology Data Exchange (ETDEWEB)

    Soendergaard Jensen, J.

    1996-08-01

    This work considers nonlinear fluid-structure interaction for a vibrating pipe containing fluid. Transverse pipe vibrations will force the fluid to move relative to the pipe creating uni-directional fluid flow towards the pipe end. The fluid flow induced affects the damping and the stiffness of the pipe. The behavior of the system in response to lateral resonant base excitation is analyzed numerically mode of vibration seems to be most effective for high mean fluid speed, whereas higher modes of vibration can be used to transport fluid with the same fluid speed but with smaller magnitude of pipe vibrations. The effect of the nonlinear geometrical terms is analyzed and these terms are shown to affect the response for higher modes of vibration. Experimental investigations show good agreement with theoretical predictions. (au) 16 refs.

  11. GOMA 6.0 : a full-Newton finite element program for free and moving boundary problems with coupled fluid/solid momentum, energy, mass, and chemical species transport : user%3CU%2B2019%3Es guide.

    Energy Technology Data Exchange (ETDEWEB)

    Schunk, Peter Randall; Rao, Rekha Ranjana; Chen, Ken Shuang; Labreche, Duane A.; Sun, Amy Cha-Tien; Hopkins, Matthew Morgan; Moffat, Harry K.; Roach, Robert Allen; Hopkins, Polly L.; Notz, Patrick K.; Roberts, Scott Alan; Sackinger, Philip A.; Subia, Samuel Ramirez; Wilkes, Edward Dean; Baer, Thomas A.; Noble, David R.; Secor, Robert B. [3M Engineering Systems and Technology, St. Paul, MN

    2013-07-01

    Goma 6.0 is a finite element program which excels in analyses of multiphysical processes, particularly those involving the major branches of mechanics (viz. fluid/solid mechanics, energy transport and chemical species transport). Goma is based on a full-Newton-coupled algorithm which allows for simultaneous solution of the governing principles, making the code ideally suited for problems involving closely coupled bulk mechanics and interfacial phenomena. Example applications include, but are not limited to, coating and polymer processing flows, super-alloy processing, welding/soldering, electrochemical processes, and solid-network or solution film drying. This document serves as a user's guide and reference.

  12. Moving a House by Moved Participants

    DEFF Research Database (Denmark)

    Axel, Erik

    The author performed an investigation of how a house was designed. He participated mainly in meetings, in which the house was engineered. The meetings proceeded in an agreeable atmosphere. While the architect was mostly concerned with integrating the functionality of the house, the engineer engaged......? The participant observer believed it was a matter of changing coordinates, but the engineers immediately saw it was an issue of pipes in the ground, could they be moved and still function as planned? To decide the possibility of this suggestion the engineer was given the task of investigating the consequences...... of moving the house with respect to its servicing pipes. It was immediately underlined that this task was a surplus task and would therefore trigger an extra payment. When I interviewed the participants and asked them how they understood the function of the engineer, they revealed some irritation, since...

  13. Embodied affectivity: On moving and being moved

    Directory of Open Access Journals (Sweden)

    Thomas eFuchs

    2014-06-01

    Full Text Available There is a growing body of research indicating that bodily sensation and behaviour strongly influences one’s emotional reaction towards certain situations or objects. On this background, a framework model of embodied affectivity is suggested: we regard emotions as resulting from the circular interaction between affective qualities or affordances in the environment and the subject’s bodily resonance, be it in the form of sensations, postures, expressive movements or movement tendencies. Motion and emotion are thus intrinsically connected: one is moved by movement (perception; impression; affection and moved to move (action; expression; e-motion. Through its resonance, the body functions as a medium of emotional perception: it colours or charges self-experience and the environment with affective valences while it remains itself in the background of one’s own awareness. This model is then applied to emotional social understanding or interaffectivity which is regarded as an intertwinement of two cycles of embodied affectivity, thus continuously modifying each partner’s affective affordances and bodily resonance. We conclude with considerations of how embodied affectivity is altered in psychopathology and can be addressed in psychotherapy of the embodied self.

  14. Embodied affectivity: on moving and being moved.

    Science.gov (United States)

    Fuchs, Thomas; Koch, Sabine C

    2014-01-01

    There is a growing body of research indicating that bodily sensation and behavior strongly influences one's emotional reaction toward certain situations or objects. On this background, a framework model of embodied affectivity is suggested: we regard emotions as resulting from the circular interaction between affective qualities or affordances in the environment and the subject's bodily resonance, be it in the form of sensations, postures, expressive movements or movement tendencies. Motion and emotion are thus intrinsically connected: one is moved by movement (perception; impression; affection) and moved to move (action; expression; e-motion). Through its resonance, the body functions as a medium of emotional perception: it colors or charges self-experience and the environment with affective valences while it remains itself in the background of one's own awareness. This model is then applied to emotional social understanding or interaffectivity which is regarded as an intertwinement of two cycles of embodied affectivity, thus continuously modifying each partner's affective affordances and bodily resonance. We conclude with considerations of how embodied affectivity is altered in psychopathology and can be addressed in psychotherapy of the embodied self. PMID:24936191

  15. Moving contact line on chemically patterned surfaces

    Science.gov (United States)

    Wang, Xiao-Ping; Qian, Tiezheng; Sheng, Ping

    We simulate the moving contact line in two-dimensional chemically patterned channels using a diffuse-interface model with the generalized Navier boundary condition. The motion of the fluidslip behaviour of the contact line. The extra dissipation induced by this oscillatory contact-line motion is significant and increases rapidly with the wettability contrast of the pattern. A critical value of the wettability contrast is identified above which the effect of diffusion becomes important, leading to the interesting behaviour of fluid-fluid interface breaking, with the transport of the non-wetting fluid being assisted and mediated by rapid diffusion through the wetting fluid. Near the critical value, the time-averaged extra dissipation scales as U, the displacement velocity. By decreasing the period of the pattern, we show the solid surface to be characterized by an effective contact angle whose value depends on the material characteristics and composition of the patterned surfaces.

  16. Moving interfaces and quasilinear parabolic evolution equations

    CERN Document Server

    Prüss, Jan

    2016-01-01

    In this monograph, the authors develop a comprehensive approach for the mathematical analysis of a wide array of problems involving moving interfaces. It includes an in-depth study of abstract quasilinear parabolic evolution equations, elliptic and parabolic boundary value problems, transmission problems, one- and two-phase Stokes problems, and the equations of incompressible viscous one- and two-phase fluid flows. The theory of maximal regularity, an essential element, is also fully developed. The authors present a modern approach based on powerful tools in classical analysis, functional analysis, and vector-valued harmonic analysis. The theory is applied to problems in two-phase fluid dynamics and phase transitions, one-phase generalized Newtonian fluids, nematic liquid crystal flows, Maxwell-Stefan diffusion, and a variety of geometric evolution equations. The book also includes a discussion of the underlying physical and thermodynamic principles governing the equations of fluid flows and phase transitions...

  17. Moving Objects Updating

    Science.gov (United States)

    Chen, Jidong; Meng, Xiaofeng

    In moving objects applications, large numbers of locations can be sampled by sensors or GPS periodically, then sent from moving clients to the server and stored in a database. Therefore, continuously maintaining in a database the current locations of moving objects by using a tracking technique becomes very important. The key issue is minimizing the number of updates, while providing precise locations for query results. In this chapter, we will introduce some underlying location update methods. Then, we describe two location update strategies in detail, which can improve the performance. One is the proactive location update strategy, which predicts the movement of moving objects to lower the update frequency; the other is the group location update strategy, which groups the objects to minimize the total number of objects reporting their locations.

  18. PARALLEL MOVING MECHANICAL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Florian Ion Tiberius Petrescu

    2014-09-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 Moving mechanical systems parallel structures are solid, fast, and accurate. Between parallel systems it is to be noticed Stewart platforms, as the oldest systems, fast, solid and precise. The work outlines a few main elements of Stewart platforms. Begin with the geometry platform, kinematic elements of it, and presented then and a few items of dynamics. Dynamic primary element on it means the determination mechanism kinetic energy of the entire Stewart platforms. It is then in a record tail cinematic mobile by a method dot matrix of rotation. If a structural mottoelement consists of two moving elements which translates relative, drive train and especially dynamic it is more convenient to represent the mottoelement as a single moving components. We have thus seven moving parts (the six motoelements or feet to which is added mobile platform 7 and one fixed.

  19. The Moving image

    DEFF Research Database (Denmark)

    Hansen, Lennard Højbjerg

    2014-01-01

    Every day we are presented with bodily expressions in audiovisual media – by anchors, journalists and characters in films for instance. This article explores how body language in the moving image has been and can be approached in a scholarly manner.......Every day we are presented with bodily expressions in audiovisual media – by anchors, journalists and characters in films for instance. This article explores how body language in the moving image has been and can be approached in a scholarly manner....

  20. Theoretical and Computational Studies of Condensed-Phase Phenomena: The Origin of Biological Homochirality, and the Liquid-Liquid Phase Transition in Network-Forming Fluids

    Science.gov (United States)

    Ricci, Francesco

    This dissertation describes theoretical and computational studies of the origin of biological homochirality, and the existence of a liquid-liquid phase transition in pure-component network-forming fluids. A common theme throughout these studies is the use of sophisticated computer simulation and statistical mechanics techniques to study complex condensed-phase phenomena. In the first part of this dissertation, we use an elementary lattice model with molecular degrees of freedom, and satisfying microscopic reversibility, to investigate the effect of reaction reversibility on the evolution of stochastic symmetry breaking via autocatalysis and mutual inhibition in a closed system. We identify conditions under which the system's evolution towards racemic equilibrium becomes extremely slow, allowing for long-time persistence of a symmetry-broken state. We also identify a "monomer purification" mechanism, due to which a nearly homochiral state can persist for long times, even in the presence of significant reverse reaction rates. Order of magnitude estimates show that with reasonable physical parameters a symmetry broken state could persist over geologically-relevant time scales. In the second part of this dissertation, we study a chiral-symmetry breaking mechanism known as Viedma ripening. We develop a Monte Carlo model to gain further insights into the mechanisms capable of reproducing key experimental signatures associated with this phenomenon. We also provide a comprehensive investigation of how the model parameters impact the system's overall behavior. It is shown that size-dependent crystal solubility alone is insufficient to reproduce most experimental signatures, and that some form of a solid-phase chiral feedback mechanism (e.g., agglomeration) must be invoked in our model. In the third part of this dissertation, we perform rigorous free energy calculations to investigate the possibility of a liquid-liquid phase transition (LLPT) in the Stillinger-Weber (SW

  1. Computational fluid dynamics

    CERN Document Server

    Blazek, Jiri

    2015-01-01

    Computational Fluid Dynamics: Principles and Applications, Third Edition presents students, engineers, and scientists with all they need to gain a solid understanding of the numerical methods and principles underlying modern computation techniques in fluid dynamics. By providing complete coverage of the essential knowledge required in order to write codes or understand commercial codes, the book gives the reader an overview of fundamentals and solution strategies in the early chapters before moving on to cover the details of different solution techniques. This updated edition includes new

  2. On the Flow of a Dusty Fluid

    Directory of Open Access Journals (Sweden)

    J.P. Singh

    1977-10-01

    Full Text Available The present paper deals with the flow of a fluid with uniform distribution of dust particles in two parts. In part A, the motion induced in the dusty fluid is considered in the case when the plane moves parallel to itself impulsively from rest with uniform velocity; for this case, the velocity profiles of fluid as well as dust particles are obtained. In part B, the flow is produced by the motion of cylinders. Two cases are taken : (i cylinders moving exponentially with time and, (ii cylinders moving in simple harmonic motion.

  3. Métodos de extração e/ou concentração de compostos encontrados em fluidos biológicos para posterior determinação cromatográfica Methods of extraction and/or concentration of compounds found in biological fluids for subsequent chromatographic determination

    Directory of Open Access Journals (Sweden)

    Sonia C. N. Queiroz

    2001-02-01

    Full Text Available When organic compounds present in biological fluids are analysed by chromatographic methods, it is generally necessary to carry out a prior sample preparation due the high complexity of this type of sample, especially when the compounds to be determinated are found in very low concentrations. This article describes some of the principal methods for sample preparation in analyses of substances present in biological fluids. The methods include liquid-liquid extraction, solid phase extraction, supercritical fluid extraction and extraction using solid and liquid membranes. The advantages and disadvantages of these methods are discussed.

  4. Plasma Waves and Jets from Moving Conductors

    CERN Document Server

    Gralla, Samuel E

    2016-01-01

    We consider force-free plasma waves launched by the motion of conducting material through a magnetic field. We develop a spacetime-covariant formalism for perturbations of a uniform magnetic field and show how the transverse motion of a conducting fluid acts as a source. We show that fast-mode waves are sourced by the compressibility of the fluid, with incompressible fluids launching a pure-Alfven outflow. Remarkably, this outflow can be written down in closed form, at the nonlinear level, for an arbitrary incompressible flow. The instantaneous flow velocity is imprinted on the magnetic field and transmitted away at the speed of light, carrying detailed information about the conducting source at the time of emission. These results can be applied to transients in pulsar outflows and to jets from neutron stars orbiting in the magnetosphere of another compact object. We discuss jets from moving conductors in some detail.

  5. Plasma waves and jets from moving conductors

    Science.gov (United States)

    Gralla, Samuel E.; Zimmerman, Peter

    2016-06-01

    We consider force-free plasma waves launched by the motion of conducting material through a magnetic field. We develop a spacetime-covariant formalism for perturbations of a uniform magnetic field and show how the transverse motion of a conducting fluid acts as a source. We show that fast-mode waves are sourced by the compressibility of the fluid, with incompressible fluids launching a pure-Alfvén outflow. Remarkably, this outflow can be written down in closed form for an arbitrary time-dependent, nonaxisymmetric incompressible flow. The instantaneous flow velocity is imprinted on the magnetic field and transmitted away at the speed of light, carrying detailed information about the conducting source at the time of emission. These results can be applied to transients in pulsar outflows and to jets from neutron stars orbiting in the magnetosphere of another compact object. We discuss jets from moving conductors in some detail.

  6. Effect of Gas/Water Ratio on the Performance of Combined Cylindrical Anoxic/Aerobic Moving Bed Biofilm Reactors for Biological Nutrients Removal from Domestic Wastewater by Fully Nitrification-Denitrification Processes

    OpenAIRE

    Husham T. Ibrahim; HEQiang; Wisaam S. Al-Rekabi

    2014-01-01

    In this research the continuously up-flow pilot scale Moving Bed Biofilm Reactor (MBBR) which was consists of combined cylindrical anoxic/aerobic MBBR in nested form with anoxic/aerobic volume ratio equal to 0.16 under fully nitrification-denitrification process were used to treated 4 m34+-N, TN and TP, respectively, while the average Dissolved Oxygen concentration (DO) in aerobic and anoxic MBBRs were 4.49 and 0.16 mg/L, respectively.

  7. Verified Null-Move Pruning

    CERN Document Server

    David-Tabibi, Omid

    2008-01-01

    In this article we review standard null-move pruning and introduce our extended version of it, which we call verified null-move pruning. In verified null-move pruning, whenever the shallow null-move search indicates a fail-high, instead of cutting off the search from the current node, the search is continued with reduced depth. Our experiments with verified null-move pruning show that on average, it constructs a smaller search tree with greater tactical strength in comparison to standard null-move pruning. Moreover, unlike standard null-move pruning, which fails badly in zugzwang positions, verified null-move pruning manages to detect most zugzwangs and in such cases conducts a re-search to obtain the correct result. In addition, verified null-move pruning is very easy to implement, and any standard null-move pruning program can use verified null-move pruning by modifying only a few lines of code.

  8. Moving up in industry.

    Science.gov (United States)

    Covell, Charlotte

    2016-01-23

    Charlotte Covell is commercial business manager at Virbac UK, a role that gives her responsibility for the company's sales to corporate practices, some buying groups and internet pharmacies. She began her career as a veterinary nurse, but moved into industry and now has a role in senior business management. PMID:26795866

  9. Indexing Moving Points

    DEFF Research Database (Denmark)

    Agarwal, Pankaj K.; Arge, Lars Allan; Erickson, Jeff

    2003-01-01

    We propose three indexing schemes for storing a set S of N points in the plane, each moving along a linear trajectory, so that any query of the following form can be answered quickly: Given a rectangle R and a real value t, report all K points of S that lie inside R at time t. We first present an...

  10. Moving beyond Disability

    NARCIS (Netherlands)

    Geertzen, Jan H. B.

    2008-01-01

    Moving beyond Disability was the theme of the 12th World Congress of the International Society for Prosthetics and Orthotics. This paper is a reflection of one of the keynote lectures discussing the International Classification of Functioning, Disability and Health (ICF). Multicultural aspects in di

  11. Moving into an interaction

    DEFF Research Database (Denmark)

    Mortensen, Kristian; Hazel, Spencer

    2014-01-01

    Opening an interaction is a crucial step in establishing and maintaining social relationships. In this paper we describe how participants in an institutional setting, a help desk counter for exchange students at an international university, literally move into interaction. This is accomplished th...

  12. Moving and union dissolution

    NARCIS (Netherlands)

    P.J. Boyle; H. Kulu; T. Cooke; V. Gayle; C.H. Mulder

    2008-01-01

    This paper examines the effect of migration and residential mobility on union dissolution among married and cohabiting couples. Moving is a stressful life event, and a large, multidisciplinary literature has shown that family migration often benefits one partner (usually the man) more than the other

  13. Making Images That Move

    Science.gov (United States)

    Rennie, Richard

    2015-01-01

    The history of the moving image (the cinema) is well documented in books and on the Internet. This article offers a number of activities that can easily be carried out in a science class. They make use of the phenomenon of "Persistence of Vision." The activities presented herein demonstrate the functionality of the phenakistoscope, the…

  14. Aboard the "Moving School."

    Science.gov (United States)

    Ainscow, Mel; Hopkins, David

    1992-01-01

    In many countries, education legislation embodies contradictory pressures for centralization and decentralization. In the United Kingdom, there is growing government control over policy and direction of schools; schools are also being given more responsibility for resource management. "Moving" schools within Improving the Quality of Education for…

  15. Synthesis and Characterization of 8-O-Carboxymethylpyranine (CM-Pyranine as a Bright, Violet-Emitting, Fluid-Phase Fluorescent Marker in Cell Biology.

    Directory of Open Access Journals (Sweden)

    Eric A Legenzov

    Full Text Available To avoid spectral interference with common fluorophores in multicolor fluorescence microscopy, a fluid-phase tracer with excitation and emission in the violet end of the visible spectrum is desirable. CM-pyranine is easily synthesized and purified. Its excitation and emission maxima at 401.5 nm and 428.5 nm, respectively, are well suited for excitation by 405-nm diode lasers now commonly available on laser-scanning microscopes. High fluorescence quantum efficiency (Q = 0.96 and strong light absorption (ε405 > 25,000 M-1cm-1 together make CM-pyranine the brightest violet aqueous tracer. The fluorescence spectrum of CM-pyranine is invariant above pH 4, which makes it a good fluid-phase marker in all cellular compartments. CM-pyranine is very photostable, is retained for long periods by cells, does not self-quench, and has negligible excimer emission. The sum of its properties make CM-pyranine an ideal fluorescent tracer. The use of CM-pyranine as a fluid-phase marker is demonstrated by multicolor confocal microscopy of cells that are also labeled with lipid and nuclear markers that have green and red fluorescence emission, respectively.

  16. Radiation Effects on the Flow and Heat Transfer over a Moving Plate in a Parallel Stream

    Institute of Scientific and Technical Information of China (English)

    Anuar Ishak

    2009-01-01

    Effects of thermal radiation on the steady laminar boundary layer flow over a moving plate in a moving fluid is investigated. Under certain conditions,the present problem reduces to the classical Blasius and Sakiadis problems.It is found that dual solutions exist when the plate and the fluid move in the opposite directions.Moreover,the existence of thermal radiation is to reduce the heat transfer rate at the surface.

  17. The Moving Flame Experiment

    OpenAIRE

    Stern, Melvin E.

    2011-01-01

    When a flame is rotated around the outside bottom rim of a cylindrical pan of water initially at rest, D. Fultz has observed that the fluid acquires a net vertical component of angular momentum opposite to the rotation of the heat source. We have repeated this experiment in a cylindrical annulus in order to restrict the radial motions and have found that the same phenomenon occurs. Using a simple model based on the latter experiment we investigate the mechanism by which a fluid can acquire an...

  18. Apparatus for Pumping a Fluid

    Science.gov (United States)

    Boeyen, Robert Van; Reeh, Jonathan

    2013-01-01

    A fluid pump has been developed for mechanically pumped fluid loops for spacecraft thermal control. Lynntech's technology utilizes a proprietary electrochemically driven pumping mechanism. Conventional rotodynamic and displacement pumps typically do not meet the stringent power and operational reliability requirements of space applications. Lynntech's developmental pump is a highly efficient solid-state pump with essentially no rotating or moving components (apart from metal bellows).

  19. Ecotoxicological testing of performance fluids

    International Nuclear Information System (INIS)

    The report deals with a project comprising the testing of drilling fluids concerning ecotoxicology, biological degradation, and toxicity. Two types of drilling fluids were tested for toxic effects on marine algae and biological degradability. A fluid based on mineral oil was readily degradable (98% DOC removal in 28 days) while an ether based oil degraded more slowly (56% DOC removal in 28 days). The toxicity of both fluids was tested after emulsification of the oils in water and separating the oil and water phase after equilibration. The EC50 values obtained with this approach were 8.15 g/l for the oil based fluid and 116 g/l for the ether fluid. 9 figs., 8 tabs

  20. Euphotic Zone Study moves forward

    Science.gov (United States)

    Denman, Kenneth

    The Global Ocean Euphotic Zone Study (GOEZS), a potential core program of the International Geosphere-Biosphere Programme (IGBP) being planned jointly with the Scientific Committee on Oceanic Research (SCOR), was recently given the go-ahead by IGBP's Scientific Committee to move on to the next level of developing its scientific program.The GOEZS program will focus on the coupled physical, biological, and chemical processes operating in the euphotic zone, which is the ocean surface layer where sufficient light penetrates for photosynthesis by phytoplankton to exceed their metabolic energy losses. The upper ocean is extremely important to understanding the atmosphereocean system because it mediates exchanges of heat, momentum, carbon dioxide, sulphur, and nitrogen between the atmosphere and the ocean interior. For the major greenhouse gas carbon dioxide for example, there is more carbon in the upper ocean than in the whole atmosphere. Essentially all carbon dioxide from the atmosphere that passes from the upper ocean to the ocean interior has been transformed chemically or biologically in the upper ocean. Moreover, the upper ocean is the site of all marine shipping and most recreation and industrial activity and contains the planktonic food chain and most fish stocks.

  1. Effect of Gas/Water Ratio on the Performance of Combined Cylindrical Anoxic/Aerobic Moving Bed Biofilm Reactors for Biological Nutrients Removal from Domestic Wastewater by Fully Nitrification-Denitrification Processes

    Directory of Open Access Journals (Sweden)

    Husham T. Ibrahim

    2014-04-01

    Full Text Available In this research the continuously up-flow pilot scale Moving Bed Biofilm Reactor (MBBR which was consists of combined cylindrical anoxic/aerobic MBBR in nested form with anoxic/aerobic volume ratio equal to 0.16 under fully nitrification-denitrification process were used to treated 4 m34+-N, TN and TP, respectively, while the average Dissolved Oxygen concentration (DO in aerobic and anoxic MBBRs were 4.49 and 0.16 mg/L, respectively.

  2. Moving Metric: Textbooks.

    Science.gov (United States)

    Hauck, George F.

    1981-01-01

    Lists engineering textbooks that use SI units. Includes author(s), title, publisher, year, and author's or publisher's comments on the use of the SI units. Books are categorized by topic, such as engineering mechanics, mechanics of materials, fluid mechanics, thermodynamics, structural design, and hydrology. (CS)

  3. Fluid Mechanics.

    Science.gov (United States)

    Drazin, Philip

    1987-01-01

    Outlines the contents of Volume II of "Principia" by Sir Isaac Newton. Reviews the contributions of subsequent scientists to the physics of fluid dynamics. Discusses the treatment of fluid mechanics in physics curricula. Highlights a few of the problems of modern research in fluid dynamics. Shows that problems still remain. (CW)

  4. Chemical, mineralogical and molecular biological characterization of the rocks and fluids from a natural gas storage deep reservoir as a baseline for the effects of geological hydrogen storage

    Science.gov (United States)

    Morozova, Daria; Kasina, Monika; Weigt, Jennifer; Merten, Dirk; Pudlo, Dieter; Würdemann, Hilke

    2014-05-01

    Planned transition to renewable energy production from nuclear and CO2-emitting power generation brings the necessity for large scale energy storage capacities. One possibility to store excessive energy produced is to transfer it to chemical forms like hydrogen which can be subsequently injected and stored in subsurface porous rock formations like depleted gas reservoirs and presently used gas storage sites. In order to investigate the feasibility of the hydrogen storage in the subsurface, the collaborative project H2STORE ("hydrogen to store") was initiated. In the scope of this project, potential reactions between microorganism, fluids and rocks induced by hydrogen injection are studied. For the long-term experiments, fluids of natural gas storage are incubated together with rock cores in the high pressure vessels under 40 bar pressure and 40° C temperature with an atmosphere containing 5.8% He as a tracer gas, 3.9% H2 and 90.3% N2. The reservoir is located at a depth of about 2 000 m, and is characterized by a salinity of 88.9 g l-1 NaCl and a temperature of 80° C and therefore represents an extreme environment for microbial life. First geochemical analyses showed a relatively high TOC content of the fluids (about 120 mg l-1) that were also rich in sodium, potassium, calcium, magnesium and iron. Remarkable amounts of heavy metals like zinc and strontium were also detected. XRD analyses of the reservoir sandstones revealed the major components: quartz, plagioclase, K-feldspar, anhydrite and analcime. The sandstones were intercalated by mudstones, consisting of quartz, plagioclase, K-feldspar, analcime, chlorite, mica and carbonates. Genetic profiling of amplified 16S rRNA genes was applied to characterize the microbial community composition by PCR-SSCP (PCR-Single-Strand-Conformation Polymorphism) and DGGE (Denaturing Gradient Gel Electrophoresis). First results indicate the presence of microorganisms belonging to the phylotypes alfa-, beta- and gamma

  5. Moving in Circles

    DEFF Research Database (Denmark)

    Simonsen, Gunvor

    2008-01-01

    The article examines the development of African diaspora history during the last fifty years. It outlines the move from a focus on African survivals to a focus on deep rooted cultural principles and back again to a revived interest in concrete cultural transfers from Africa to the Americas. This...... circular movement can be explained by a combination of elements characterizing African Atlantic and black Atlantic history. Among them is a lack of attention to questions of periodisation and change. Likewise, it has proven difficult to conceptualize Africa and America at one and the same time as...... characterized by cultural diversity and variation. Moreover, the field has been haunted by a tendency of moving to easily from descriptive evidence to conclusions about African identity in the Americas. A promising way to overcome these problems, it is suggested, is to develop research that focuses on single...

  6. What moves us?

    DEFF Research Database (Denmark)

    2015-01-01

    Le Corbusier (1887-1965) is arguably one the most influential architects of the 20th century. In the Scandinavian countries, his influence is most pronounced in the writings and art of the Danish experimentalist Asger Jorn (1914–1973). Their collaboration on Le Corbusier’s pavilion for the 1937...... Paris World Exhibition sparked Jorn’s lifelong fascination with the great architect and with architecture more broadly as an inherently public form of art. At the same time, Le Corbusier began revealing his work in visual art and started to move from a rational, technological towards a more poetic......, materialist approach to architecture. What Moves Us? focuses specifically on the reception of Le Corbusier in Scandinavia, with the relationship between Jorn and Le Corbusier as a thematic thread. The book first highlights the architect’s change of direction and subsequently takes readers through his...

  7. 壳聚糖/丝胶蛋白生物流体材料的制备及性能测试%Preparation and Property Characterization of Chitosan/Sericin Biological Fluid Material

    Institute of Scientific and Technical Information of China (English)

    严晨峰; 刘琳; 姚菊明

    2013-01-01

    To overcome the limitation of commercial wound dressings with poor fluid absorption capability,a novel chitosan/sericin biological fluid material was successfully prepared by using chitosan extracted from shells of sea crabs and sericin discarded as waste material in silk industry as the major materials.The unique biological material was tawny,semitransparent and semi-fluid.It could form soft and transparent film,functioning as a natural barrier against infection.Its fluid absorption capability and permeability could be adjusted by changing the ratio of chitosan to sericin.Its moist absorption capability and water vapor permeability was in the range of 2.33 ~23.73 g/g and 2 738 ~3 752 g/(m2 ·d) respectively,being able to satisfy the needs in healing various wounds.The mechanical property of resultant film slightly reduced after addition of sericin,but it still kept excellent flexibility to satisfy clinical demand of wound dressing.In vitro antibacterial experiment indicated that,although the addition of sericin reduced antibacterial activity of the fluid material,its antibacterial rate was as high as 83% against Staphylococcus aureus when the mass ratio of chitosan to sericin was 1 ∶ 0.6,being able to prevent wound infection effectively.These results indicate that the novel chitosan/sericin biological fluid materials have good perspective in clinical application.%针对现有医用敷料吸收渗液能力不强等缺点,以海洋蟹虾外壳中提取的壳聚糖和蚕丝加工过程废弃的丝胶蛋白为主要原料,研制出一种新型生物流体材料.该材料为黄褐色半透明、半流动物质,能形成柔韧透明的薄膜从而起到防感染的天然屏障作用.通过改变壳聚糖与丝胶蛋白的配比,可以有效调控壳聚糖/丝胶蛋白生物流体材料膜的吸液能力和通透性等,其吸水量、水蒸汽透过率分别分布在2.33~ 23.73 g/g和2 738 ~3 752 g/(m2·d)之间,可以满足不同程度创面修复需要.虽

  8. Luxury consumption moves East

    DEFF Research Database (Denmark)

    Khan, Omera

    2015-01-01

    Purpose – The literature contains relatively little prescriptive guidance for establishing supply chain strategies in the luxury fashion marketplace. The focus has been on fashion rather than luxury fashion and the purpose of this paper is to identify and explore the critical supply chain success...... novel insights to transformations in global supply chain strategy as luxury consumption is moving towards the east, which creates new challenges and demands for European manufacturers to respond, to sustaining a competitive advantage....

  9. CERN Pension Fund move

    CERN Document Server

    HR Department

    2007-01-01

    The CERN Pension Fund has moved to new offices on the 5th floor of Building 5. The Benefits Service of the Fund is now located in Offices 5-5-017 - 5-5-021 - 5-5-023. We remind you that the office hours are: Tuesday/Wednesday/Thursday from 10 am to 12 am and from 3 pm to 5 pm. The Fund would like to take this opportunity to warmly thank all the persons involved in the relocation.

  10. Lecture - "Move! Eat better"

    CERN Multimedia

    2012-01-01

    As part of the "Move! Eat better" campaign, Novae’s nutrition adviser, Irène Rolfo, will give a talk on the subject of everyday good nutrition. This will be held in the main building auditorium at 12:30 on Thursday, 20 September 2012. Don’t miss this informative event. For more information, go to http://cern.ch/bpmm            

  11. A moving experience !

    CERN Multimedia

    2005-01-01

    The Transport Service pulled out all the stops and, more specifically, its fleet of moving and lifting equipment for the Discovery Monday on 6 June - a truly moving experience for all the visitors who took part ! Visitors could play at being machine operator, twiddling the controls of a lift truck fitted with a jib to lift a dummy magnet into a wooden mock-up of a beam-line.They had to show even greater dexterity for this game of lucky dip...CERN-style.Those with a head for heights took to the skies 20 m above ground in a telescopic boom lift.Children were allowed to climb up into the operator's cabin - this is one of the cranes used to move the LHC magnets around. Warm thanks to all members of the Transport Service for their participation, especially B. Goicoechea, T. Ilkei, R. Bihery, S. Prodon, S. Pelletier, Y. Bernard, A.  Sallot, B. Pigeard, S. Guinchard, B. Bulot, J. Berrez, Y. Grandjean, A. Bouakkaz, M. Bois, F. Stach, T. Mazzarino and S. Fumey.

  12. Rupture Limit of Thin Moving Films

    Science.gov (United States)

    Padrino, Juan C.; Joseph, Daniel D.; Kim, Hyungjun

    2010-11-01

    The rupture of a thin film in another fluid is studied including the effects of disjoining pressure. The study considers the linear stability of a moving viscous film in a motionless inviscid fluid and of a stagnant viscous film in a motionless viscous fluid. These are analyzed by means of the Navier--Stokes equations and the dissipation approximation based on potential flow. Results reveal that the dissipation method provides a good approximation for the case of a moving film, whereas its predictions are off the mark for the stagnant film case. The thickness of the gap at the trough of Kelvin-Helmholtz waves locates the formation of holes. The wavelength at final collapse is determined by the length of waves at the trough of the corrugated film. The disjoining pressure effects cause very fast break-up for very thin films. These effects influence the cutoff wavenumber. In the limit of small gaps on this corrugated film, the Reynolds and Weber numbers tend to zero with the gap size, the Ohnesorge number increases like the reciprocal of the square root and the Hamaker number like the reciprocal of the square of the gap. The motion of the film does not enter at the point of formation of holes. Moreover, for the most unstable wave, the ratio of the wavelength to film thickness is found to decrease with decreasing film thickness.

  13. Determination of Gemfibrozil (Lipitor and Lopid) in Water, Biological Fluids and Drug Matrix by Dispersive Liquid-Liquid micro Extraction (DLLME) and Liquid Chromatography

    OpenAIRE

    Ghorbani A.; Dayani M.

    2014-01-01

    In this study Dispersive liquid-liquid micro extraction (DLLME) coupled with High performance liquid chromatography was applied for the determination of Gemfibrozil in water, drug`s matrix and biological liquids (human plasma and urine). In this method, the appropriate mixture of extraction solvent (200 μl chlorophorm) and disperser solvent (1 ml methanol) are injected rapidly into the aqueous sample (10.0 ml) by syringe, cloudy solution is formed that consisted of fine particles of extractio...

  14. To Move or Not to Move? The Relationship between Career Management and Preferred Career Moves

    OpenAIRE

    Vos, A; K. DEWETTINCK; D. BUYENS

    2006-01-01

    This paper explores professional employees’ career move preferences and the impact of both individual and organizational career management. Departing from theoretical work on the “new career”, different types of career moves employees can make on the internal labor market are discussed (i.e. vertical moves, lateral moves, job enrichment and temporary moves). Next, these are related to the literature on both organizational and individual career management. Hypotheses are formulated about profe...

  15. No Moving Parts

    Science.gov (United States)

    1998-01-01

    Under a NASA SBIR (Small Business Innovative Research), Research International developed the solid state micromachined pump used for cooling electronics in space, circulation of heat transfer fluids on spacecraft, and monitoring fire and gas hazards aboard naval warships. Incorporating Lewis Research Center's pumping technology, commercial applications for this product include both detection of toxins and pollutants in coal mines, and early warning smoke detectors for industrial applications.

  16. Understanding the bioavailability and sequestration of different metal cations in the presence of a biodegradable chelant S,S-EDDS in biological fluids and natural waters.

    Science.gov (United States)

    Bretti, Clemente; Cigala, Rosalia Maria; De Stefano, Concetta; Lando, Gabriele; Sammartano, Silvio

    2016-05-01

    Ethylenediamine-N,N'-disuccinic acid is a biodegradable alternative to EDTA, therefore its use for the sequestration of Ca(2+), Sn(2+), Cu(2+), Zn(2+) and Fe(3+) is analyzed. New data on its binding ability towards these cations were obtained with potentiometric, voltammetric and calorimetric measurements at different ionic strengths and at T = 298.15 K. Real multi-component fluids, namely fresh water, urine, sea water, saliva and blood plasma were chosen as case studies to evaluate the sequestering ability of EDDS in comparison with EDTA. Speciation diagrams were drawn in selected conditions, considering all interactions among the "natural" components of the fluid and those studied in this work, EDDS and EDTA (cL = 1 mmol dm(-3)) as sequestering agents and the cited metal cations (cM ∼ 10(-5) mol dm(-3)). The comparison of the sequestering ability of EDDS and EDTA is done using pM and pL0.5. In blood plasma the plasma mobilizing index was adopted. It was found that EDDS is a good alternative to EDTA, which tends to bind Ca(2+) and Mg(2+) more than EDDS. In particular, EDTA cannot be used as a sequestrant for Sn(2+) when cCa > cEDTA. EDDS is more efficient than EDTA at pH PMI of EDDS towards Cu(2+) is higher than that of EDTA. Thermodynamic information, in terms of ΔH and ΔS, for the protonation and metal complex formation reactions are reported. PMID:26921587

  17. Understanding the bioavailability and sequestration of different metal cations in the presence of a biodegradable chelant S,S-EDDS in biological fluids and natural waters.

    Science.gov (United States)

    Bretti, Clemente; Cigala, Rosalia Maria; De Stefano, Concetta; Lando, Gabriele; Sammartano, Silvio

    2016-05-01

    Ethylenediamine-N,N'-disuccinic acid is a biodegradable alternative to EDTA, therefore its use for the sequestration of Ca(2+), Sn(2+), Cu(2+), Zn(2+) and Fe(3+) is analyzed. New data on its binding ability towards these cations were obtained with potentiometric, voltammetric and calorimetric measurements at different ionic strengths and at T = 298.15 K. Real multi-component fluids, namely fresh water, urine, sea water, saliva and blood plasma were chosen as case studies to evaluate the sequestering ability of EDDS in comparison with EDTA. Speciation diagrams were drawn in selected conditions, considering all interactions among the "natural" components of the fluid and those studied in this work, EDDS and EDTA (cL = 1 mmol dm(-3)) as sequestering agents and the cited metal cations (cM ∼ 10(-5) mol dm(-3)). The comparison of the sequestering ability of EDDS and EDTA is done using pM and pL0.5. In blood plasma the plasma mobilizing index was adopted. It was found that EDDS is a good alternative to EDTA, which tends to bind Ca(2+) and Mg(2+) more than EDDS. In particular, EDTA cannot be used as a sequestrant for Sn(2+) when cCa > cEDTA. EDDS is more efficient than EDTA at pH < 8, particularly in urine, where carbonate is absent. In sea water, the sequestering ability of EDDS towards Fe(3+) is higher than that of EDTA. In blood plasma, the PMI of EDDS towards Cu(2+) is higher than that of EDTA. Thermodynamic information, in terms of ΔH and ΔS, for the protonation and metal complex formation reactions are reported.

  18. Bacterial Chemotaxis with a Moving Target

    Science.gov (United States)

    Dominick, Corey

    2015-03-01

    Most chemotaxis studies so far have been conducted in a quiescent fluid with a well-defined chemical gradient. Such experiments may be appropriate for studying enteric bacteria, such as Escherichia coli, but the environment it provides is very different from that typically encountered by marine bacteria. Herein we describe an experiment in which marine bacterium Vibrio alginolyticusis subject to stimulation by a small moving target. A micropipette of the tip size <1 ?m is used to slowly release a chemoattractant, serine, at different concentrations. The pipette is made to move with different patterns and speeds, ranging from 0 to 100 ?m/s; the latter is about twice the bacterial swimming speed. We found that if the pipette is moved slowly, with 1/4 of bacterial swimming speed, cells accumulate near the tip region but when it is moved with speed greater than 1/2 the bacterial swimming speed, cells trail behind the pipette over a large distance. The behaviors observed in V. alginolyticusare significantly different from E. coli, suggesting that the former is a better chemotaxer in a changing environment.

  19. Drop Impact on to Moving Liquid Pools

    Science.gov (United States)

    Muñoz-Sánchez, Beatriz Natividad; Castrejón-Pita, José Rafael; Castrejón-Pita, Alfonso Arturo; Hutchings, Ian M.

    2014-11-01

    The deposition of droplets on to moving liquid substrates is an omnipresent situation both in nature and industry. A diverse spectrum of phenomena emerges from this simple process. In this work we present a parametric experimental study that discerns the dynamics of the impact in terms of the physical properties of the fluid and the relative velocity between the impacting drop and the moving liquid pool. The behaviour ranges from smooth coalescence (characterized by little mixing) to violent splashing (generation of multiple satellite droplets and interfacial vorticity). In addition, transitional regimes such as bouncing and surfing are also found. We classify the system dynamics and show a parametric diagram for the conditions of each regime. This work was supported by the EPSRC (Grant EP/H018913/1), the Royal Society, Becas Santander Universidades and the International Relationships Office of the University of Extremadura.

  20. Electrodynamics of moving magnetoelectric media: variational approach

    CERN Document Server

    Obukhov, Yuri N

    2007-01-01

    Recently, Feigel has predicted a new effect in magnetoelectric media. The theoretical evaluation of this effect requires a careful analysis of a dynamics of the moving magnetoelectric medium and, in particular, the derivation of the energy-momentum of the electromagnetic field in such a medium. Then, one can proceed with the study of the wave propagation in this medium and derive the mechanical quantities such as the energy, the momentum, and their fluxes and the corresponding forces. In this paper, we develop a consistent general-relativistic variational approach to the moving dielectric and magnetic medium with and without magnetoelectric properties. The old experiments in which the light pressure was measured in fluids are reanalysed in our new framework.

  1. Electrodynamics of moving magnetoelectric media: Variational approach

    Energy Technology Data Exchange (ETDEWEB)

    Obukhov, Yuri N. [Institute for Theoretical Physics, University of Cologne, 50923 Cologne (Germany); Department of Theoretical Physics, Moscow State University, 117234 Moscow (Russian Federation)], E-mail: yo@htp.uni-koeln.de; Hehl, Friedrich W. [Institute for Theoretical Physics, University of Cologne, 50923 Cologne (Germany); Department of Physics and Astronomy, University of Missouri-Columbia, Columbia, MO 65211 (United States)], E-mail: hehl@thp.uni-koeln.de

    2007-11-05

    Recently, Feigel has predicted a new effect in magnetoelectric media. The theoretical evaluation of this effect requires a careful analysis of a dynamics of the moving magnetoelectric medium and, in particular, the derivation of the energy-momentum of the electromagnetic field in such a medium. Then, one can proceed with the study of the wave propagation in this medium and derive the mechanical quantities such as the energy, the momentum, and their fluxes and the corresponding forces. In this Letter, we develop a consistent general-relativistic variational approach to the moving dielectric and magnetic medium with and without magnetoelectric properties. The old experiments in which the light pressure was measured in fluids are reanalysed in our new framework.

  2. Moving Spatial Keyword Queries

    DEFF Research Database (Denmark)

    Wu, Dingming; Yiu, Man Lung; Jensen, Christian S.

    2013-01-01

    text data. State-of-the-art solutions for moving queries employ safe zones that guarantee the validity of reported results as long as the user remains within the safe zone associated with a result. However, existing safe-zone methods focus solely on spatial locations and ignore text relevancy. We...... zones, we study analytically the expected area of a safe zone, which indicates on average for how long a safe zone remains valid, and we study the expected number of influence objects needed to define a safe zone, which gives an estimate of the average communication cost. The analytical modeling...

  3. CERN Pension Fund move

    CERN Multimedia

    HR Department

    2007-01-01

    The CERN Pension Fund has moved to new offices at the 5th floor of Building 5. The Benefits Service of the Fund will henceforth receive you in the offices: 5-5-017 - 5-5-021 - 5-5-023. We remind you that the office hours are: Tuesday/Wednesday/Thursday from 10 am to 12 am and from 3 pm to 5 pm. The Fund would like to take this opportunity to warmly thank all the persons involved in the Removal.

  4. Time to Move On?

    DEFF Research Database (Denmark)

    Valentino, A.; Nell, Phillip Christopher; Hotho, Jasper J.

    economic crises influence the effects of the institutional factors in our model. We argue that economic crises have a dual effect on the international configuration of HQ activities. First, during times of crisis, we expect firms to react stronger to coercive, isomorphic, and normative pressures. Second......, we expect economic crises to decrease the overall institutional quality in a given country context, pushing firms to move out. Our theoretical framework contributes to an improved understanding of how institutional factors influence firm behaviour under varying environmental conditions. Furthermore...

  5. Forces on bodies moving unsteadily in rapidly compressed flows

    OpenAIRE

    Eames, I.; Hunt, J.C.R.

    2004-01-01

    The inviscid compressible flow generated by a rigid body of volume V moving unsteadily with a velocity U in a rapidly compressed homentropic flow is considered. The fluid is compressed isentropically at a rate del.v(0) uniformly over a scale much larger than the size of the body and the body moves slowly enough that the Mach number M is low. The flow is initially irrotational and remains so during compression. The perturbation to the flow generated by the body moving unsteadily is non-diverge...

  6. Numerical Simulation of Wave Interaction with Moving Net Structures

    DEFF Research Database (Denmark)

    Chen, Hao; Christensen, Erik Damgaard

    2015-01-01

    Fluid structure interaction is an important issue in designof many engineering systems including offshore fish cages. As a first step to develop a coupled CFD/FEM model, in the present study a moving porous media model has been developed in the open source library Open FOAM. The net structure...... was described as a sheet of porous media with prescribed rigid body motion and mesh motion was incorporated to conform the motion of the net. Free surface wave generation and absorption framework was also introduced to simulate wave interaction with moving net structures. The results showed that mesh motion...... with moving net structures....

  7. Shadowfax: Moving mesh hydrodynamical integration code

    Science.gov (United States)

    Vandenbroucke, Bert

    2016-05-01

    Shadowfax simulates galaxy evolution. Written in object-oriented modular C++, it evolves a mixture of gas, subject to the laws of hydrodynamics and gravity, and any collisionless fluid only subject to gravity, such as cold dark matter or stars. For the hydrodynamical integration, it makes use of a (co-) moving Lagrangian mesh. The code has a 2D and 3D version, contains utility programs to generate initial conditions and visualize simulation snapshots, and its input/output is compatible with a number of other simulation codes, e.g. Gadget2 (ascl:0003.001) and GIZMO (ascl:1410.003).

  8. Ready, set, move!

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    This year, the CERN Medical Service is launching a new public health campaign. Advertised by the catchphrase “Move! & Eat Better”, the particular aim of the campaign is to encourage people at CERN to take more regular exercise, of whatever kind.   The CERN annual relay race is scheduled on 24 May this year. The CERN Medical Service will officially launch its “Move! & Eat Better” campaign at this popular sporting event. “We shall be on hand on the day of the race to strongly advocate regular physical activity,” explains Rachid Belkheir, one of the Medical Service doctors. "We really want to pitch our campaign and answer any questions people may have. Above all we want to set an example. So we are going to walk the same circuit as the runners to underline to people that they can easily incorporate movement into their daily routine.” An underlying concern has prompted this campaign: during their first few year...

  9. Conjugation of glucose oxidase onto Mn-doped ZnS quantum dots for phosphorescent sensing of glucose in biological fluids.

    Science.gov (United States)

    Wu, Peng; He, Yu; Wang, He-Fang; Yan, Xiu-Ping

    2010-02-15

    Integrating various enzymes with nanomaterials provides various nanohybrids with new possibilities in biosensor applications. Furthermore, the enzymatic activity and stability are also improved due to the large surface area of nanomaterials. Here we report the conjugation of glucose oxidase (GOD) onto phosphorescent Mn-doped ZnS quantum dots (QDs) using 1-ethyl-3-(3-dimethylaminopropy)carbodiimide (EDC)/N-hydroxysuccinimide (NHS) as coupling reagents for glucose biosensing based on the effective quenching of the room temperature phosphorescence (RTP) of Mn-doped ZnS QDs by the H(2)O(2) generated from GOD-catalyzed oxidation of glucose. The obtained bioconjugate not only provided improved enzymatic performance with Michaelis-Menten constant of 0.70 mM but also favored biological applications because the phosphorescent detection mode avoided the interference from autofluorescence and scattering light from the biological matrix. In addition, the GOD-conjugated Mn-doped ZnS QDs showed better thermal stability in the temperature range of 20-80 degrees C. The GOD-Mn-doped ZnS QDs based RTP sensor for glucose gave a detection limit of 3 microM and two linear ranges from 10 microM to 0.1 mM and from 0.1 to 1 mM. The developed biosensor was successfully applied to the determination of glucose in real serum samples without the need for any complicated sample pretreatments. PMID:20092317

  10. Textured fluids

    OpenAIRE

    Guenther, Gerhard K.

    1995-01-01

    The rheology and development morphology of textured fluids have been investigated. The first fluid considered in this work was a liquid crystalline polymer consisting of isotropic and anisotropic solutions of poly-p-phenyleneterephthalamide (PPT) in sulfuric acid. The second textured fluid considered in this work was an immiscible polymer blend consisting of poly(ethylene terephthalate) (PET) and nylon 6,6. The role played by liquid crystalline order (LCO) and a polydomain ...

  11. Moving wheelchairs with your thoughts

    OpenAIRE

    Duca, Edward

    2012-01-01

    Brain to computer interface (BCI) devices can read a person’s thoughts and turn them into commands to move objects. They can give freedom to people suffering from movement impairments. Rosanne Zerafa (supervised by Tracey Camilleri) developed a system that detects a person’s brain patterns while they are thinking of moving a particular part of their body and translates them into commands to move a cursor. http://www.um.edu.mt/think/moving-wheelchairs-with-your-thoughts/

  12. Fluid mechanics

    CERN Document Server

    Kundu, Pijush K; Dowling, David R

    2011-01-01

    Fluid mechanics, the study of how fluids behave and interact under various forces and in various applied situations-whether in the liquid or gaseous state or both-is introduced and comprehensively covered in this widely adopted text. Revised and updated by Dr. David Dowling, Fluid Mechanics, 5e is suitable for both a first or second course in fluid mechanics at the graduate or advanced undergraduate level. Along with more than 100 new figures, the text has been reorganized and consolidated to provide a better flow and more cohesion of topics.Changes made to the

  13. Are we ready to move beyond the reductionist approach of classical synergy control?. Comment on "Hand synergies: Integration of robotics and neuroscience for understanding the control of biological and artificial hands" by Marco Santello et al.

    Science.gov (United States)

    Lacquaniti, Francesco; Ivanenko, Yuri P.; Zago, Myrka

    2016-07-01

    Starting from the classical concepts introduced by Sherrington [1] and considerably elaborated by Bernstein [2], much has been learned about motor synergies in the last several years. The contributions of the group funded by the European project "The Hand Embodied" are remarkable in the field of biological and robotic control of the hand based on synergies, and they are reflected in this enjoyable review [3]. There, Santello et al. adopt Bernstein's definition of motor synergies as multiple elements working together towards a common goal, with the result that multiple degrees of freedom are controlled within a lower-dimensional space than the available number of dimensions.

  14. A Novel HPLC Method for the Concurrent Analysis and Quantitation of Seven Water-Soluble Vitamins in Biological Fluids (Plasma and Urine: A Validation Study and Application

    Directory of Open Access Journals (Sweden)

    Margherita Grotzkyj Giorgi

    2012-01-01

    Full Text Available An HPLC method was developed and validated for the concurrent detection and quantitation of seven water-soluble vitamins (C, B1, B2, B5, B6, B9, B12 in biological matrices (plasma and urine. Separation was achieved at 30°C on a reversed-phase C18-A column using combined isocratic and linear gradient elution with a mobile phase consisting of 0.01% TFA aqueous and 100% methanol. Total run time was 35 minutes. Detection was performed with diode array set at 280 nm. Each vitamin was quantitatively determined at its maximum wavelength. Spectral comparison was used for peak identification in real samples (24 plasma and urine samples from abstinent alcohol-dependent males. Interday and intraday precision were <4% and <7%, respectively, for all vitamins. Recovery percentages ranged from 93% to 100%.

  15. Development of a molecular recognition based approach for multi-residue extraction of estrogenic endocrine disruptors from biological fluids coupled to liquid chromatography-tandem mass spectrometry measurement.

    Science.gov (United States)

    Bousoumah, Radia; Antignac, Jean Philippe; Camel, Valérie; Grimaldi, Marina; Balaguer, Patrick; Courant, Frederique; Bichon, Emmanuelle; Morvan, Marie-Line; Le Bizec, Bruno

    2015-11-01

    Multi-residue methods permitting the high-throughput and affordable simultaneous determination of an extended range of endocrine disrupting chemicals (EDCs) with reduced time and cost of analysis is of prime interest in order to characterize a whole set of bioactive compounds. Such a method based on UHPLC-MS/MS measurement and dedicated to 13 estrogenic EDCs was developed and applied to biological matrices. Two molecular recognition-based strategies, either molecular imprinted polymer (MIP) with phenolic template or estrogen receptors (ERα) immobilized on a sorbent, were assessed in terms of recovery and purification efficiency. Both approaches demonstrated their suitability to measure ultra-trace levels of estrogenic EDCs in aqueous samples. Applicability of the MIP procedure to urine and serum samples has also been demonstrated. PMID:26391401

  16. What moves us?

    DEFF Research Database (Denmark)

    2015-01-01

    Katalog til udstillingen på Museum Jorn - What moves us? Le Corbusier & Asger Jorn - 12. sept. - 13. dec. 2015. Kataloget undersøger Le Corbusiers skifte fra en rationelt funderet tilgang til arkitekturen til en poetisk, materialistisk tilgang i efterkrigstiden. Den viser hans indflydelse på den...... yngre Asger Jorn og beskriver danskerens første beundring, som sidenhen forvandledes til skarp kritik. Kataloget, som er rigt illustreret med billeder af Le Corbusiers og Asger Jorns kunst og arkitektur, indeholder også genoptryk af originale tekster, samt bidrag i ord og billeder fra fremtrædende...... eksperter. Kataloget indeholder en række artikler af internationale skribenter under flg. overskrifter: Le Corbusier - kunstnerarkitekten i efterkrigstidens Europa Le Corbusier og Asger Jorn - David mod Goliat Gensyn med Le Corbusier - spor i dansk arkitektur og byrum...

  17. Move! Eat better: news

    CERN Multimedia

    2013-01-01

    Are you curious to know whether you’re doing enough daily exercise…? Test yourself with a pedometer!   Through the Move! Eat better campaign, launched in May 2012, the CERN medical service is aiming to improve the health of members of the personnel by encouraging them to prioritise physical activity in conjunction with a balanced diet. Various successful activities have already taken place: relay race/Nordic walk, Bike2work, Zumba and fitness workshops, two conferences (“Physical activity for health” and “Good nutrition every day”), events in the restaurants, as well as posters and a website. Although everyone has got the message from our various communications that physical activity is good for your health, there is still a relevant question being asked: “What is the minimum amount of exercise recommended?” 10,000 steps per day is the ideal figure, which has been demonstrated as beneficial by scientific studies ...

  18. Moving Detectors in Cavities

    CERN Document Server

    Obadia, N

    2007-01-01

    We consider two-level detectors, coupled to a quantum scalar field, moving inside cavities. We highlight some pathological resonant effects due to abrupt boundaries, and decide to describe the cavity by switching smoothly the interaction by a time-dependent gate-like function. Considering uniformly accelerated trajectories, we show that some specific choices of non-adiabatic switching have led to hazardous interpretations about the enhancement of the Unruh effect in cavities. More specifically, we show that the emission/absorption ratio takes arbitrary high values according to the emitted quanta properties and to the transients undergone at the entrance and the exit of the cavity, {\\it independently of the acceleration}. An explicit example is provided where we show that inertial and uniformly accelerated world-lines can even lead to the same ``pseudo-temperature''.

  19. Moving Beyond Outsourcing

    DEFF Research Database (Denmark)

    Rai, Sudhanshu

    In this article I discuss the Indian outsourcing phenomena and ask the question now what? Using data from the Euro-India project I demonstrate that a small but significant part of the Indian IT entities are moving beyond outsourcing, to co-creation where Innovation and the desire to create new...... markets is the key driver. This does not imply that outsourcing will disappear but it does mean that firms will engage in globalization using innovative mix of business models and technical platforms. We discuss the implication of this slow transformation to co-creation of innovation for the global...... outsourcing industry. The key thesis of this paper is to discuss co-creation as a form of innovation and how such a form of innovation is likely to bring Indian companies rich dividends....

  20. Moving Single Atoms

    Science.gov (United States)

    Stuart, Dustin

    2016-05-01

    Single neutral atoms are promising candidates for qubits, the fundamental unit of quantum information. We have built a set of optical tweezers for trapping and moving single Rubidium atoms. The tweezers are based on a far off-resonant dipole trapping laser focussed to a 1 μm spot with a single aspheric lens. We use a digital micromirror device (DMD) to generate dynamic holograms of the desired arrangement of traps. The DMD has a frame rate of 20 kHz which, when combined with fast algorithms, allows for rapid reconfiguration of the traps. We demonstrate trapping of up to 20 atoms in arbitrary arrangements, and the transport of a single-atom over a distance of 14 μm with continuous laser cooling, and 5 μm without. In the meantime, we are developing high-finesse fibre-tip cavities, which we plan to use to couple pairs of single atoms to form a quantum network.

  1. Moving the implementation line

    DEFF Research Database (Denmark)

    Carugati, Andrea; Giangreco, A.; Sebastiano, A.

    2011-01-01

    embraces the call to develop evolving systems in continuously emergent organizations and to identify the main factors that can lead to continuous system development—a continuously moving implementation line—from within the organization. In doing so, we draw on a longitudinal analysis of the experience...... of a typical Western nursing home that, in the past 12 years, has aimed to internally develop a healthcare provision and management system to support its evolving needs. Our analysis shows that four factors enable this concurrent change: (1) the internal appreciation of change, (2) the external appreciation...... of change, (3) enlightened management, and (4) emancipated employees. By controlling for the latter two factors, managers of long-term care centers can motivate employees to contribute to the development of the system over long periods and limit undesired behaviors with information technology (IT). From...

  2. Multinationals Move Inland

    Institute of Scientific and Technical Information of China (English)

    CHRIS; DEVONSHIRE-ELLIS

    2008-01-01

    Central China, initially overlooked by many foreign investors as being too far from the ports in Tianjin, Shanghai and Shenzhen, is emerging as an essential destination for multinationals in China.The Future of Central China: A Provincial Roadmap There is a huge manufacturing drive in central China. Businesses are moving inland to set up projects, investments and operations here, primarily due to lower labor and land costs as well as preferential policies for manufacturers. Multinational companies also are starting to view the region as the next step toward an integrated China strategy, and the consumer population in the second-and third-tier cities in central China represents a growing, largely untapped domestic market for foreign products and services.

  3. Visual Simulation of Multiple Unmixable Fluids

    Institute of Scientific and Technical Information of China (English)

    Wen Zheng; Jun-Hai Yong; Jean-Claude Paul

    2007-01-01

    We present a novel grid-based method for simulating multiple unmixable fluids moving and interacting.Unlike previous methods that can only represent the interface between two fluids (usually between liquid and gas), this method can handle an arbitrary number of fluids through multiple independent level sets coupled with a constrain condition.To capture the fluid surface more accurately, we extend the particle level set method to a multi-fluid version.It shares the advantages of the particle level set method, and has the ability to track the interfaces of multiple fluids.To handle the dynamic behavior of different fluids existing together, we use a multiphase fluid formulation based on a smooth weight function.

  4. Fluid Dynamics

    DEFF Research Database (Denmark)

    Brorsen, Michael

    These lecture notes are intended mainly for the 7th semester course "Fluid Dynamics" offered by the Study Committee on Civil Engineering, Aalborg University.......These lecture notes are intended mainly for the 7th semester course "Fluid Dynamics" offered by the Study Committee on Civil Engineering, Aalborg University....

  5. CHINA ON THE MOVE

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A holiday train special for migrant workers in Hangzhou, east China’s Zhejiang Province, takes to the track before the kick-off of the 2007 Spring Festival travel peak, carrying more than 1,000 passengers back to their homes in Guizhou Province. China’s railways and highways are reportedly ready to transport a record 156 million and 2 billion passengers between February 3 and March 14, up 4.3 and 5 percent year on year, respectively, said government sources. Chinese traditionally travel home for family reunions on the Spring Festival, which falls on February 18 this year. In addition to a freeze on transport fares to benefit the public, transportation authorities have also taken measures to keep vehicle flows fluid during the rush period. A total of 318 pairs of temporary passenger trains will be added to ease the traffic pressure.

  6. Mixed hemimicelles solid-phase extraction based on sodium dodecyl sulfate (SDS)-coated nano-magnets for the spectrophotometric determination of Fingolomid in biological fluids

    Science.gov (United States)

    Azari, Zhila; Pourbasheer, Eslam; Beheshti, Abolghasem

    2016-01-01

    In this study, mixed hemimicelles solid-phase extraction (SPE) based on sodium dodecyl sulfate (SDS)-coated nano-magnets Fe3O4 was investigated as a novel method for the separation and determination of Fingolimod (FLM) in water, urine and plasma samples prior to spectrophotometeric determination. Due to the high surface area of these new sorbents and the excellent adsorption capacity after surface modification by SDS, satisfactory extraction recoveries can be produced. The main factors affecting the adsolubilization of analysts, such as pH, surfactant and adsorbent amounts, ionic strength, extraction time and desorption conditions were studied and optimized. Under the selected conditions, FLM has been quantitatively extracted. The accuracy of the method was evaluated by recovery measurements on spiked samples, and good recoveries of 96%, 95% and 88% were observed for water, urine and plasma respectively. Proper linear behaviors over the investigated concentration ranges of 2-26, 2-17 and 2-13 mg/L with good coefficients of determination, 0.998, 0.997 and 0.995 were achieved for water, urine and plasma samples, respectively. To the best of our knowledge, this is the first time that a mixed hemimicelles SPE method based on magnetic separation and nanoparticles has been used as a simple and sensitive method for monitoring of FLM in water and biological samples.

  7. Determination of Gemfibrozil (Lipitor and Lopid in Water, Biological Fluids and Drug Matrix by Dispersive Liquid-Liquid micro Extraction (DLLME and Liquid Chromatography

    Directory of Open Access Journals (Sweden)

    Ghorbani A.

    2014-07-01

    Full Text Available In this study Dispersive liquid-liquid micro extraction (DLLME coupled with High performance liquid chromatography was applied for the determination of Gemfibrozil in water, drug`s matrix and biological liquids (human plasma and urine. In this method, the appropriate mixture of extraction solvent (200 μl chlorophorm and disperser solvent (1 ml methanol are injected rapidly into the aqueous sample (10.0 ml by syringe, cloudy solution is formed that consisted of fine particles of extraction solvent which is dispersed entirely into aqueous phase. The mixture was centrifuged and the extraction solvent is sedimented on the bottom of the conical test tube. 50 μl of the sedimented phase is puted in a vial and it`s solvent is evaporated. Then 1ml methanol injected to vial and 20 μL of it injected into the HPLC for separation and determination of Gemfibrozil. Some important parameters, such as kind of extraction and disperser solvent, volume of them, extraction time, pH and ionic strength of the aqueous feed solution were optimized. Under the optimum conditions, the enrichment factors and extraction recoveries were 10 and 93.64%. The linear range was (0.1-100.0 mgl-1, limit of detection was 12.3 mgl-1. The relative standard deviations (RSD for 2 mgl-1 of Gemfibrozil in water were 1.3%, (n=10.

  8. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology

    Science.gov (United States)

    Wendel, Marco; Bazhenova, Lyudmila; Boshuizen, Rogier; Kolatkar, Anand; Honnatti, Meghana; Cho, Edward H.; Marrinucci, Dena; Sandhu, Ajay; Perricone, Anthony; Thistlethwaite, Patricia; Bethel, Kelly; Nieva, Jorge; van den Heuvel, Michel; Kuhn, Peter

    2012-02-01

    Circulating tumor cell (CTC) counts are an established prognostic marker in metastatic prostate, breast and colorectal cancer, and recent data suggest a similar role in late stage non-small cell lung cancer (NSCLC). However, due to sensitivity constraints in current enrichment-based CTC detection technologies, there are few published data about CTC prevalence rates and morphologic heterogeneity in early-stage NSCLC, or the correlation of CTCs with disease progression and their usability for clinical staging. We investigated CTC counts, morphology and aggregation in early stage, locally advanced and metastatic NSCLC patients by using a fluid-phase biopsy approach that identifies CTCs without relying on surface-receptor-based enrichment and presents them in sufficiently high definition (HD) to satisfy diagnostic pathology image quality requirements. HD-CTCs were analyzed in blood samples from 78 chemotherapy-naïve NSCLC patients. 73% of the total population had a positive HD-CTC count (>0 CTC in 1 mL of blood) with a median of 4.4 HD-CTCs mL-1 (range 0-515.6) and a mean of 44.7 (±95.2) HD-CTCs mL-1. No significant difference in the medians of HD-CTC counts was detected between stage IV (n = 31, range 0-178.2), stage III (n = 34, range 0-515.6) and stages I/II (n = 13, range 0-442.3). Furthermore, HD-CTCs exhibited a uniformity in terms of molecular and physical characteristics such as fluorescent cytokeratin intensity, nuclear size, frequency of apoptosis and aggregate formation across the spectrum of staging. Our results demonstrate that despite stringent morphologic inclusion criteria for the definition of HD-CTCs, the HD-CTC assay shows high sensitivity in the detection and characterization of both early- and late-stage lung cancer CTCs. Extensive studies are warranted to investigate the prognostic value of CTC profiling in early-stage lung cancer. This finding has implications for the design of extensive studies examining screening, therapy and surveillance in

  9. Fluid biopsy for circulating tumor cell identification in patients with early-and late-stage non-small cell lung cancer: a glimpse into lung cancer biology

    International Nuclear Information System (INIS)

    Circulating tumor cell (CTC) counts are an established prognostic marker in metastatic prostate, breast and colorectal cancer, and recent data suggest a similar role in late stage non-small cell lung cancer (NSCLC). However, due to sensitivity constraints in current enrichment-based CTC detection technologies, there are few published data about CTC prevalence rates and morphologic heterogeneity in early-stage NSCLC, or the correlation of CTCs with disease progression and their usability for clinical staging. We investigated CTC counts, morphology and aggregation in early stage, locally advanced and metastatic NSCLC patients by using a fluid-phase biopsy approach that identifies CTCs without relying on surface-receptor-based enrichment and presents them in sufficiently high definition (HD) to satisfy diagnostic pathology image quality requirements. HD-CTCs were analyzed in blood samples from 78 chemotherapy-naïve NSCLC patients. 73% of the total population had a positive HD-CTC count (>0 CTC in 1 mL of blood) with a median of 4.4 HD-CTCs mL−1 (range 0–515.6) and a mean of 44.7 (±95.2) HD-CTCs mL−1. No significant difference in the medians of HD-CTC counts was detected between stage IV (n = 31, range 0–178.2), stage III (n = 34, range 0–515.6) and stages I/II (n = 13, range 0–442.3). Furthermore, HD-CTCs exhibited a uniformity in terms of molecular and physical characteristics such as fluorescent cytokeratin intensity, nuclear size, frequency of apoptosis and aggregate formation across the spectrum of staging. Our results demonstrate that despite stringent morphologic inclusion criteria for the definition of HD-CTCs, the HD-CTC assay shows high sensitivity in the detection and characterization of both early- and late-stage lung cancer CTCs. Extensive studies are warranted to investigate the prognostic value of CTC profiling in early-stage lung cancer. This finding has implications for the design of extensive studies examining screening, therapy and

  10. Diffusion theory in biology: a relic of mechanistic materialism.

    Science.gov (United States)

    Agutter, P S; Malone, P C; Wheatley, D N

    2000-01-01

    Diffusion theory explains in physical terms how materials move through a medium, e.g. water or a biological fluid. There are strong and widely acknowledged grounds for doubting the applicability of this theory in biology, although it continues to be accepted almost uncritically and taught as a basis of both biology and medicine. Our principal aim is to explore how this situation arose and has been allowed to continue seemingly unchallenged for more than 150 years. The main shortcomings of diffusion theory will be briefly reviewed to show that the entrenchment of this theory in the corpus of biological knowledge needs to be explained, especially as there are equally valid historical grounds for presuming that bulk fluid movement powered by the energy of cell metabolism plays a prominent note in the transport of molecules in the living body. First, the theory's evolution, notably from its origins in connection with the mechanistic materialist philosophy of mid nineteenth century physiology, is discussed. Following this, the entrenchment of the theory in twentieth century biology is analyzed in relation to three situations: the mechanism of oxygen transport between air and mammalian tissues; the structure and function of cell membranes; and the nature of the intermediary metalbolism, with its implicit presumptions about the intracellular organization and the movement of molecules within it. In our final section, we consider several historically based alternatives to diffusion theory, all of which have their precursors in nineteenth and twentieth century philosophy of science.

  11. Finite Element Analysis of Fluid-Conveying Timoshenko Pipes

    Directory of Open Access Journals (Sweden)

    Chih-Liang Chu

    1995-01-01

    Full Text Available A general finite element formulation using cubic Hermitian interpolation for dynamic analysis of pipes conveying fluid is presented. Both the effects of shearing deformations and rotary inertia are considered. The development retains the use of the classical four degrees-of-freedom for a two-node element. The effect of moving fluid is treated as external distributed forces on the support pipe and the fluid finite element matrices are derived from the virtual work done due to the fluid inertia forces. Finite element matrices for both the support pipe and moving fluid are derived and given explicitly. A numerical example is given to demonstrate the validity of the model.

  12. Role of moving planes and moving spheres following Dupin cyclides

    KAUST Repository

    Jia, Xiaohong

    2014-03-01

    We provide explicit representations of three moving planes that form a μ-basis for a standard Dupin cyclide. We also show how to compute μ-bases for Dupin cyclides in general position and orientation from their implicit equations. In addition, we describe the role of moving planes and moving spheres in bridging between the implicit and rational parametric representations of these cyclides. © 2014 Elsevier B.V.

  13. A Moving Frame Algorithm for High Mach Number Hydrodynamics

    CERN Document Server

    Trac, H; Trac, Hy; Pen, Ue-Li

    2004-01-01

    We present a new approach to Eulerian computational fluid dynamics that is designed to work at high Mach numbers encountered in astrophysical hydrodynamic simulations. The Eulerian fluid conservation equations are solved in an adaptive frame moving with the fluid where Mach numbers are minimized. The moving frame approach uses a velocity decomposition technique to define local kinetic variables while storing the bulk kinetic components in a smoothed background velocity field that is associated with the grid velocity. Gravitationally induced accelerations are added to the grid, thereby minimizing the spurious heating problem encountered in cold gas flows. Separately tracking local and bulk flow components allows thermodynamic variables to be accurately calculated in both subsonic and supersonic regions. A main feature of the algorithm, that is not possible in previous Eulerian implementations, is the ability to resolve shocks and prevent spurious heating where both the preshock and postshock Mach numbers are h...

  14. Voltammetric Studies of Propranolol and Hydrochlorothiazide Oxidation in Standard and Synthetic Biological Fluids Using a Nitrogen-Containing Tetrahedral Amorphous Carbon (ta-C:N) Electrode

    International Nuclear Information System (INIS)

    Graphical abstract: - Highlights: • Nitrogen-containing tetrahedral amorphous carbon electrode for electroanalysis. • Electrochemical behavior of propranolol (PROP) and hydrochlorothiazide (HTZ). • ta-C:N electrode presents good electrochemical performance for PROP and HTZ. • Electrochemical performance of ta-C:N electrode is similar to the BDD electrode. • PROP and HTZ are simultaneously quantified in artificial biological samples. - Abstract: The electrochemical detection of two pharmaceuticals, propranolol (PROP) and hydrochlorothiazide (HTZ), was studied using a nitrogen-containing tetrahedral amorphous carbon (ta-C:N) electrode. Measurements were also made using a boron-doped diamond (BDD) electrode, for comparison. The ta-C:N electrode functioned well for the simultaneous determination of PROP and HTZ in artificial urine and serum by square-wave voltammetry, both of which were detected at high positive potentials. The PROP (ca. 1.2 V) and HTZ (ca. 1.4 V) oxidation peak potentials were separated by about 200 mV. The respective analytical response curves presented good linearity in the investigated concentration range from 0.9 to 9.8 μmol L−1 for PROP and from 3.0 to 9.8 μmol L−1 for HTZ with calculated limits of detection (S/N = 3) of 0.75 μmol L−1 (∼194 ng/mL) for PROP and 2.50 μmol L−1 (∼744 ng/mL) for HTZ. Essentially, the lowest concentration measured voltammetrically was the LOD. The results indicate that the ta-C:N electrode could be an excellent new carbon material for electrochemically-active analytes requiring high potentials for detection

  15. Fluid juggling

    CERN Document Server

    Soto, Enrique

    2013-01-01

    This fluid dynamics video is an entry for the Gallery of Fluid Motion for the 66th Annual Meeting of the Fluid Dynamics Division of the American Physical Society. We show the curious behaviour of a light ball interacting with a liquid jet. For certain conditions, a ball can be suspended into a slightly inclined liquid jet. We studied this phenomenon using a high speed camera. The visualizations show that the object can be `juggled' for a variety of flow conditions. A simple calculation showed that the ball remains at a stable position due to a Bernoulli-like effect. The phenomenon is very stable and easy to reproduce.

  16. Move and eat better

    CERN Multimedia

    2012-01-01

    CERN has many traditions, but in a week that’s seen the launch of the Medical Service’s  ‘Move & eat better’ campaign, it’s refreshing to note that among the oldest is a sporting one.  The CERN relay race dates back to 15 October 1971 when 21 pioneering teams set off to pound the pavements of CERN. Back then, the Focus users group came in first with a time of 12 minutes and 42 seconds. Today’s route is slightly different, and the number of teams has risen to over 100, with a new category of Nordic Walking introduced, as part of the campaign, for the first time.   The relay has provided some memorable events, and perhaps one of the longest-standing records in the history of sport, with the UA1 strollers’ 10 minutes and 13 seconds unbeaten for thirty years. In the women’s category, the UN Gazelles set the fastest time of 13 minutes and 16 seconds in 1996, while in the veterans category, you wi...

  17. ATLAS starts moving in

    CERN Multimedia

    Della Mussia, S

    2004-01-01

    The first large active detector component was lowered into the ATLAS cavern on 1st March. It consisted of the 8 modules forming the lower part of the central barrel of the tile hadronic calorimeter. The work of assembling the barrel, which comprises 64 modules, started the following day. Two road trailers each with 64 wheels, positioned side by side. This was the solution chosen to transport the lower part of the central barrel of ATLAS' tile hadronic calorimeter from Building 185 to the PX16 shaft at Point 1 (see Figure 1). The transportation, and then the installation of the component in the experimental cavern, which took place over three days were, to say the least, rather spectacular. On 25 February, the component, consisting of eight 6-metre modules, was loaded on to the trailers. The segment of the barrel was transported on a steel support so that it wouldn't move an inch during the journey. On 26 February, once all the necessary safety checks had been carried out, the convoy was able to leave Buildi...

  18. Move your body!

    Institute of Scientific and Technical Information of China (English)

    撒哈拉

    2005-01-01

    还怀念当年跳舞毯风靡的时光吗?左脚、右脚向前.向后,在不经意间展示你炫目的舞步。而最近PS2平台上的《EyeToy》让我们又接触到了一种需要游戏者舞动身体来参与的摄像头游戏.既玩了游戏又锻炼了身体.而昂达Eyebob摄像头让PC用户也能参与其中。想要玩玩摄像头游戏.现在不用转投Ps2的阵营.也不用改造你的硬件.只要你拥有一款摄像头.你就可以和家人与朋友轻松享受游戏的乐趣。来吧!Come on! Move your body now!

  19. Cell survival studies for moving targets

    International Nuclear Information System (INIS)

    More than 330 patients with static tumors have been treated at GSI with a scanned C-12 beam. For targets that are subject to respiratory motion, treatment is not yet possible because target motion and scanning motion interfere. GSI is developing a motion compensation system to compensate target motion by adaptation of each individual Bragg peak position. Within this project, the GSI treatment planning software TRiP was extended to calculate physical dose distributions in the presence of motion. These motion extensions were experimentally validated. Recently we included the calculation of cell survival for moving targets. To validate the software, a program of experimental studies with biological samples has been started. In a first set of experiments, living cell cultures were placed on a periodically moving table and irradiated with and without motion compensation. Results are compared to reference cell cultures that were static during standard irradiations. Furthermore, measured cell survival distributions are compared to calculated distributions for all irradiation schemes

  20. Fluid dynamics

    CERN Document Server

    Bernard, Peter S

    2015-01-01

    This book presents a focused, readable account of the principal physical and mathematical ideas at the heart of fluid dynamics. Graduate students in engineering, applied math, and physics who are taking their first graduate course in fluids will find this book invaluable in providing the background in physics and mathematics necessary to pursue advanced study. The book includes a detailed derivation of the Navier-Stokes and energy equations, followed by many examples of their use in studying the dynamics of fluid flows. Modern tensor analysis is used to simplify the mathematical derivations, thus allowing a clearer view of the physics. Peter Bernard also covers the motivation behind many fundamental concepts such as Bernoulli's equation and the stream function. Many exercises are designed with a view toward using MATLAB or its equivalent to simplify and extend the analysis of fluid motion including developing flow simulations based on techniques described in the book.

  1. Congestion and residential moving behaviour

    DEFF Research Database (Denmark)

    Larsen, Morten Marott; Pilegaard, Ninette; Van Ommeren, Jos

    2008-01-01

    we study how congestion and residential moving behaviour are interrelated, using a two-region job search model. Workers choose between interregional commuting and residential moving, in order to live closer to their place of work. This choice affects the external costs of commuting, due to conges......we study how congestion and residential moving behaviour are interrelated, using a two-region job search model. Workers choose between interregional commuting and residential moving, in order to live closer to their place of work. This choice affects the external costs of commuting, due...

  2. Biology Education Research 2.0

    OpenAIRE

    Dolan, Erin L.

    2015-01-01

    Biology education research (BER) 2.0 has arrived, and is moving the BER community beyond showing that active learning works to understanding the individual and contextual factors that explain and influence biology teaching and learning.

  3. Locomotion in complex fluids: Integral theorems

    CERN Document Server

    Lauga, Eric

    2014-01-01

    The biological fluids encountered by self-propelled cells display complex microstructures and rheology. We consider here the general problem of low-Reynolds number locomotion in a complex fluid. {Building on classical work on the transport of particles in viscoelastic fluids,} we demonstrate how to mathematically derive three integral theorems relating the arbitrary motion of an isolated organism to its swimming kinematics {in a non-Newtonian fluid}. These theorems correspond to three situations of interest, namely (1) squirming motion in a linear viscoelastic fluid, (2) arbitrary surface deformation in a weakly non-Newtonian fluid, and (3) small-amplitude deformation in an arbitrarily non-Newtonian fluid. Our final results, valid for a wide-class of {swimmer geometry,} surface kinematics and constitutive models, at most require mathematical knowledge of a series of Newtonian flow problems, and will be useful to quantity the locomotion of biological and synthetic swimmers in complex environments.

  4. Moving contact line problem: Advances and perspectives

    Directory of Open Access Journals (Sweden)

    Yapu Zhao

    2014-01-01

    Full Text Available The solid-liquid interface, which is ubiquitous in nature and our daily life, plays fundamental roles in a variety of physical-chemical-biological-mechanical phenomena, for example in lubrication, crystal growth, and many biological reactions that govern the building of human body and the functioning of brain. A surge of interests in the moving contact line (MCL problem, which is still going on today, can be traced back to 1970s primarily because of the existence of the “Huh-Scriven paradox”. This paper, mainly from a solid mechanics perspective, describes very briefly the multidisciplinary nature of the MCL problem, then summarizes some major advances in this exciting research area, and some future directions are presented.

  5. Shielding of moving line charges

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Youmei; He, Bingyu [Department of Physics, School of Science, Hangzhou Dianzi University, Hangzhou 310018 (China); Yu, Wei [Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800 (China); Yu, M.Y., E-mail: myyu@zju.edu.cn [Institute for Fusion Theory and Simulation and Department of Physics, Zhejiang University, Hangzhou 310027 (China); Institute for Theoretical Physics I, Ruhr University, D-44780 Bochum (Germany)

    2015-07-03

    A charged object moving in plasma can excite plasma waves that inevitably modify its Debye shielding characteristics. When the excited waves propagate sufficiently fast, the shielding can even break down. Here the properties of finite amplitude plasma waves excited by a moving line charge are investigated. It is found that when the speed of the latter is close to but less than the thermal speed of the background plasma electrons, only a localized disturbance in the form of a soliton that moves together with the line charge is excited. That is, the line charge is well shielded even though it is moving at a high speed and has generated a large local electrostatic field. However, for a pair of line charges moving together, such complete shielding behavior could not be found.

  6. R Fluids

    Directory of Open Access Journals (Sweden)

    Caimmi, R.

    2008-06-01

    Full Text Available A theory of collisionless fluids is developed in a unified picture, where nonrotating $(widetilde{Omega_1}=widetilde{Omega_2}= widetilde{Omega_3}=0$ figures with some given random velocity component distributions, and rotating $(widetilde{Omega_1} ewidetilde{Omega_2} e widetilde{Omega_3} $ figures with a different random velocity component distributions, make adjoint configurations to the same system. R fluids are defined as ideal, self-gravitating fluids satisfying the virial theorem assumptions, in presence of systematic rotation around each of the principal axes of inertia. To this aim, mean and rms angular velocities and mean and rms tangential velocity components are expressed, by weighting on the moment of inertia and the mass, respectively. The figure rotation is defined as the mean angular velocity, weighted on the moment of inertia, with respectto a selected axis. The generalized tensor virial equations (Caimmi and Marmo 2005 are formulated for R fluidsand further attention is devoted to axisymmetric configurations where, for selected coordinateaxes, a variation in figure rotation has to be counterbalanced by a variation in anisotropy excess and viceversa. A microscopical analysis of systematic and random motions is performed under a fewgeneral hypotheses, by reversing the sign of tangential or axial velocity components of anassigned fraction of particles, leaving the distribution function and other parametersunchanged (Meza 2002. The application of the reversion process to tangential velocitycomponents is found to imply the conversion of random motion rotation kinetic energy intosystematic motion rotation kinetic energy. The application ofthe reversion process to axial velocity components is found to imply the conversionof random motion translation kinetic energy into systematic motion translation kinetic energy, and theloss related to a change of reference frame is expressed in terms of systematic motion (imaginary rotation kinetic

  7. Dynamic response of a poroelastic stratum to moving oscillating load

    Institute of Scientific and Technical Information of China (English)

    CHEN YuanGuo; JIN Bo

    2008-01-01

    The dynamic response of a poroelastic stratum subjected to moving load is studied.The governing dynamic equations for poroelasUc medium are solved by using Fourier transform. The general solutions for the stresses and displacements in the transformed domain are established. Based on the general solutions, with the consideration of boundary conditions, the final expressions of stresses and displacements in physical domain are put forward for the three-dimensional single-layer medium. Some numerical solutions for the stresses, displacements and pore fluid pressure are presented and reveal that the response of a poroelastic stratum varies obviously with the moving velocity.

  8. Dynamic response of a poroelastic stratum to moving oscillating load

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The dynamic response of a poroelastic stratum subjected to moving load is studied. The governing dynamic equations for poroelastic medium are solved by using Fourier transform. The general solutions for the stresses and displacements in the transformed domain are established. Based on the general solutions, with the consideration of boundary conditions, the final expressions of stresses and displacements in physical domain are put forward for the three-dimensional single-layer medium. Some numerical solutions for the stresses, displacements and pore fluid pressure are presented and reveal that the response of a poroelastic stratum varies obviously with the moving velocity.

  9. Gaussian moving averages and semimartingales

    DEFF Research Database (Denmark)

    Basse-O'Connor, Andreas

    2008-01-01

    In the present paper we study moving averages (also known as stochastic convolutions) driven by a Wiener process and with a deterministic kernel. Necessary and sufficient conditions on the kernel are provided for the moving average to be a semimartingale in its natural filtration. Our results...... are constructive - meaning that they provide a simple method to obtain kernels for which the moving average is a semimartingale or a Wiener process. Several examples are considered. In the last part of the paper we study general Gaussian processes with stationary increments. We provide necessary and sufficient...

  10. Crust-Mantle Structures and Gold Enrichment Mechanism of Mantle Fluid System

    Institute of Scientific and Technical Information of China (English)

    邓军; 孙忠实; 王庆飞; 韦延光

    2003-01-01

    Gold enrichment mechanism of ore-forming fluid is the essence of gold metallization.This paper summarizes the distinguishing symbols of mantle fluid and effect of crust-mantlestructure on fluid movement. Fluid moving processes include osmosis, surge, gas-liquid alterna-tion and mutation of fluid speed. During fluid movement, gold will be enriched gradually. Final-ly, a layered circulatory system is illustrated in this paper.

  11. Protides of the biological fluids, 1985

    Energy Technology Data Exchange (ETDEWEB)

    Peeters, H.

    1985-01-01

    This book contains three sections, each consisting of several papers. The section headings are: Plasma Protein Genes; Antinuclear Antibodies (ANA); and Methodologies. Some of the paper titles are: A Comparison of Three Methods for the Assay of Anti-DNA Antibodies; IEF and 2D-Electrophoresis with Narrow and Ultranarrow Immobilized pH Gradients for the Analysis of Genetic Variants; Genetic Studies of Apolipoprotein A-IV by Two-Dimensional Electrophoresis; and Two-Dimensional Electrophoretic Analysis of Genetic Muscle Disorders.

  12. Rehabilitation Counselor Certification: Moving Forward

    Science.gov (United States)

    Saunders, Jodi L.; Barros-Bailey, Mary; Chapman, Cindy; Nunez, Patricia

    2009-01-01

    This article provides a brief history of the Commission on Rehabilitation Counselor Certification and presents recent changes and strategic goals for moving forward. Challenges and opportunities for the profession in relation to certification are also discussed. (Contains 3 tables.)

  13. NPS MOVES - Entertainment Research Directions

    OpenAIRE

    Zyda, Michael

    2000-01-01

    Outline: Zyda Bio in Book Covers, NRC report & its impact on VR/CG research, The future of networked entertainment, Research required by entertainment & defense to provide this future, The NPS MOVES Research Center & its Entertainment/Defense Agenda ...

  14. Study of moving reflector vibrations

    International Nuclear Information System (INIS)

    The results on the experimental study of occasional vibrations of the IBR-2 moving reflectors are given. The influence of the moving reflector structure, the level of their axial and phase oscillations and periods of reflector rotation on the external reactivity fluctuations is analysed. The methods of the statistical analysis of the stationary bicomponent time series are used for experimental data processing. It is shown that at the period of the IBR-2 energy start-up the uncontrolled reactivity fluctuations due to the moving reflector vibrations were rather insignificant (4.5+-2.7x10-6 δ K/K). The construction of the reactivity modulator with the moving reflector as trident provides the regular reactor operation in the mean power range of 0-2 MeV

  15. Autowaves in moving excitable media

    Directory of Open Access Journals (Sweden)

    V.A.Davydov

    2004-01-01

    Full Text Available Within the framework of kinematic theory of autowaves we suggest a method for analytic description of stationary autowave structures appearing at the boundary between the moving and fixed excitable media. The front breakdown phenomenon is predicted for such structures. Autowave refraction and, particulary, one-side "total reflection" at the boundary is considered. The obtained analytical results are confirmed by computer simulations. Prospects of the proposed method for further studies of autowave dynamics in the moving excitable media are discussed.

  16. How Moving Backgrounds Influence Interception

    OpenAIRE

    Eli Brenner; Smeets, Jeroen B. J.

    2015-01-01

    Reaching movements towards an object are continuously guided by visual information about the target and the arm. Such guidance increases precision and allows one to adjust the movement if the target unexpectedly moves. On-going arm movements are also influenced by motion in the surrounding. Fast responses to motion in the surrounding could help cope with moving obstacles and with the consequences of changes in one's eye orientation and vantage point. To further evaluate how motion in the surr...

  17. Modeling of Dynamic Fluid Forces in Fast Switching Valves

    DEFF Research Database (Denmark)

    Roemer, Daniel Beck; Johansen, Per; Pedersen, Henrik Clemmensen;

    2015-01-01

    Switching valves experience opposing fluid forces due to movement of the moving member itself, as the surrounding fluid volume must move to accommodate the movement. This movement-induced fluid force may be divided into three main components; the added mass term, the viscous term and the socalled...... history term. For general valve geometries there are no simple solution to either of these terms. During development and design of such switching valves, it is therefore, common practice to use simple models to describe the opposing fluid forces, neglecting all but the viscous term which is determined...... based on shearing areas and venting channels. For fast acting valves the opposing fluid force may retard the valve performance significantly, if appropriate measures are not taken during the valve design. Unsteady Computational Fluid Dynamics (CFD) simulations are available to simulate the total fluid...

  18. Fluid Mechanics

    Science.gov (United States)

    Pnueli, David; Gutfinger, Chaim

    1997-01-01

    This text is intended for the study of fluid mechanics at an intermediate level. The presentation starts with basic concepts, in order to form a sound conceptual structure that can support engineering applications and encourage further learning. The presentation is exact, incorporating both the mathematics involved and the physics needed to understand the various phenomena in fluid mechanics. Where a didactical choice must be made between the two, the physics prevails. Throughout the book the authors have tried to reach a balance between exact presentation, intuitive grasp of new ideas, and creative applications of concepts. This approach is reflected in the examples presented in the text and in the exercises given at the end of each chapter. Subjects treated are hydrostatics, viscous flow, similitude and order of magnitude, creeping flow, potential flow, boundary layer flow, turbulent flow, compressible flow, and non-Newtonian flows. This book is ideal for advanced undergraduate students in mechanical, chemical, aerospace, and civil engineering. Solutions manual available.

  19. Peristaltic transport of Conducting Bingham fluid in contact with a Newtonian fluid in a channel

    Directory of Open Access Journals (Sweden)

    M.Arun kumar

    2013-04-01

    Full Text Available Peristaltic pumping by a sinusoidal traveling wave in the walls of a two dimensional channel filled with two immiscible fluids with magnetic effect is investigated. The core region of the channel is occupied by a Bingham fluid where as the peripheral region is occupied by a Newtonian fluid. The flow is examined in a wave frame of reference moving with the velocity of the wave. The expressions for the stream function, the velocity and the pressure rise are obtained. The equation for the interface separating the two fluids is obtained. Numerical results are reported for several of the physical parameters of interest. We observed that the lower values of

  20. Fluid dynamics

    CERN Document Server

    Ruban, Anatoly I

    This is the first book in a four-part series designed to give a comprehensive and coherent description of Fluid Dynamics, starting with chapters on classical theory suitable for an introductory undergraduate lecture course, and then progressing through more advanced material up to the level of modern research in the field. The present Part 1 consists of four chapters. Chapter 1 begins with a discussion of Continuum Hypothesis, which is followed by an introduction to macroscopic functions, the velocity vector, pressure, density, and enthalpy. We then analyse the forces acting inside a fluid, and deduce the Navier-Stokes equations for incompressible and compressible fluids in Cartesian and curvilinear coordinates. In Chapter 2 we study the properties of a number of flows that are presented by the so-called exact solutions of the Navier-Stokes equations, including the Couette flow between two parallel plates, Hagen-Poiseuille flow through a pipe, and Karman flow above an infinite rotating disk. Chapter 3 is d...

  1. Determinação voltamétrica de metais em águas e fluidos biológicos empregando mineralização de amostras com radiação ultravioleta Voltammetric determination of metals in waters and biological fluids using sample mineralization with ultraviolet radiation

    Directory of Open Access Journals (Sweden)

    Leandro M. de Carvalho

    2008-01-01

    Full Text Available This work describes the optimization of pretreatment steps for the destruction of organic matter in samples of waters and biological fluids, by using an UV irradiation system with a high power UV radiation source (400 W. The efficiency of the system constructed for the photo-decomposition of samples of model waters, natural waters and biological fluids was investigated by performing recovery experiments of the metallic species Zn(II, Cd(II, Pb(II, Cu(II, Al(III and Fe(III. The use of UV irradiation allowed the liberation of metals bound to the organic matrix and the determination of the total content of elements in the samples.

  2. Adding ecology to particle capture models: numerical simulations of capture on a moving cylinder in crossflow.

    Science.gov (United States)

    Krick, Julian; Ackerman, Josef Daniel

    2015-03-01

    The particle capture efficiency, η, of systems that remove suspended particles from ambient flow (e.g. suspension feeding, abiotic pollination) has been studied using static collectors in steady flows. Particle deposition on collectors moving due to fluid flow remains largely unknown, despite its ecological relevance. We used numerical modeling to simulate particle deposition on a 2D circular cylinder subject to flow-induced oscillation in a cross flow. Using parameter values relevant to wind pollination and other natural biological systems, we examined the influence of the direction, amplitude and frequency of the oscillation, the Stokes number (Stk=0.01-5, characterizing particle behavior), as well as the Reynolds number (Re=662 and 3309, characterizing flow regime) in steady and unsteady flow, on η. The numerical model was validated with empirical results for parts of the parameter space. Particle capture occurred via "inertial impaction", "direct interception" and "leeward deposition", as well as via a new mechanism, "collector chasing" for moving collectors. The η of an oscillating cylinder varied significantly relative to a static cylinder, depending on the parameters used, and on the magnitude of a numerical error that caused loss of particles. This variance of η was due to a change in relative momentum between the particle and the moving collector, which depends on Re, Stk and the oscillation parameters. Collector oscillation transverse to oncoming flow direction strongly increased η, whereas collector motion parallel to flow had little effect on capture efficiency. The oscillation also changed leeward capture significantly in some cases. For most conditions, however, leeward deposition was small. Results suggest that collector motion could have significant influence on the particle capture efficiency of natural systems, which indicates the need to incorporate these ecologically more relevant findings into current models. Empirical studies, however

  3. Moving Shadows, Moving Sun. Early Modem Sundials Restaging Miracles.

    Science.gov (United States)

    Mersmann, Jasmin

    2015-01-01

    Irrespective of geo- or heliocentric presuppositions, the functioning of sundials is based on the observation of moving shadows or light spots. Even though the cast shadow was often simply used to indicate the time, it could also remind the users of the ephemerality of earthly things or function as an index of planetary movements. This article examines the various ways in which early modem sundials visually interpret the moving shadow or light spot. The instruments address the shadow in inscriptions, integrate it into their design (e.g., in cruciform dials) or even manipulate its course (as in the so-called Horologium Ahaz). Both the crucifix and the Ahaz dials not only refer to astronomical miracles but actually restage them. Even though by means of the horologium it was not possible to explain the Old Testament miracle of the shadow moving backward, adepts were able to recreate it on a terrestrial scale. PMID:26495586

  4. Flow Diode and Method for Controlling Fluid Flow Origin of the Invention

    Science.gov (United States)

    Dyson, Rodger W (Inventor)

    2015-01-01

    A flow diode configured to permit fluid flow in a first direction while preventing fluid flow in a second direction opposite the first direction is disclosed. The flow diode prevents fluid flow without use of mechanical closures or moving parts. The flow diode utilizes a bypass flowline whereby all fluid flow in the second direction moves into the bypass flowline having a plurality of tortuous portions providing high fluidic resistance. The portions decrease in diameter such that debris in the fluid is trapped. As fluid only travels in one direction through the portions, the debris remains trapped in the portions.

  5. Pumping by flapping in a viscoelastic fluid

    CERN Document Server

    Pak, On Shun

    2010-01-01

    In a world without inertia, Purcell's scallop theorem states that in a Newtonian fluid a time-reversible motion cannot produce any net force or net flow. Here we consider the extent to which the nonlinear rheological behavior of viscoelastic fluids can be exploited to break the constraints of the scallop theorem in the context of fluid pumping. By building on previous work focusing on force generation, we consider a simple, biologically-inspired geometrical example of a flapper in a polymeric (Oldroyd-B) fluid, and calculate asymptotically the time-average net fluid flow produced by the reciprocal flapping motion. The net flow occurs at fourth order in the flapping amplitude, and suggests the possibility of transporting polymeric fluids using reciprocal motion in simple geometries even in the absence of inertia. The induced flow field and pumping performance are characterized and optimized analytically. Our results may be useful in the design of micro-pumps handling complex fluids.

  6. Superlubricity: A Paradox about Confined Fluids Resolved

    Science.gov (United States)

    Zhu, Yingxi; Granick, Steve

    2004-08-01

    Using the method of Frantz and Salmeron to cleave mica [Tribol. Lett.TRLEFS1023-8883 5, 151 (1998)10.1023/A:1019149910047] we investigate alkane fluids in a surface forces apparatus and confirm several predictions of molecular dynamics (MD) simulation. An oscillatory force-distance profile is observed for the methyl-branched alkane, squalane. Boundary slip is inferred from the frictional sliding of molecularly thin fluids and also from the hydrodynamic flow of thicker films. These findings resolve the paradox that prior experiments disagreed with these aspects of MD predictions, and demonstrate that exceptionally low energy dissipation is possible when fluids move past solid surfaces that are sufficiently smooth.

  7. Explaining immigrants’ moves into homeownership

    DEFF Research Database (Denmark)

    Andersen, Hans Skifter

    In the paper is examined the reasons for when and why immigrants in Greater Copenhagen move into homeownership after their 25th year based on data from the years 1990 to 2008 compared to residents with a Danish background. As for natives homeownership to a large extent is dependent on income......, employment and family situation, and actual changes, but the importance of these factors differ from Danes. Different immigrant groups have a somewhat lower propensity to move into homeownership than Danes, which only to some extent can be explained by differences in income, education and employment. Living...... in social housing and in multi-ethnic neighbourhoods reduces the probability of moving into homeownership. But there are still some unexplained reasons for lower homeownership rate among immigrants. A probable hypothesis is that immigrants are more uncertain about their future employment and income...

  8. Transmission Lines Emulating Moving Media

    CERN Document Server

    Vehmas, Joni; Tretyakov, Sergei

    2014-01-01

    In this paper, we show how the electromagnetic phenomena in moving magnetodielectric media can be emulated using artificial composite structures at rest. In particular, we introduce nonreciprocal periodically loaded transmission lines which support waves obeying the same rules as plane electromagnetic waves in moving media. Because the actual physical structure is at rest, in these transmission lines there are no fundamental limitations on the velocity values, which may take values larger than the speed of light or even complex values (considering complex amplitudes in the time-harmonic regime). An example circuit of a unit cell of a "moving" transmission line is presented and analyzed both numerically and experimentally. The special case of composite right/left handed host line is also studied numerically. Besides the fundamental interest, the study is relevant for potential applications in realizing engineered materials for various transformations of electromagnetic fields.

  9. Pericardial Fluid Analysis

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? Pericardial Fluid Analysis Share this page: Was this page helpful? Formal name: Pericardial Fluid Analysis Related tests: Pleural Fluid Analysis , Peritoneal Fluid Analysis , ...

  10. Peritoneal Fluid Analysis

    Science.gov (United States)

    ... Home Visit Global Sites Search Help? Peritoneal Fluid Analysis Share this page: Was this page helpful? Formal name: Peritoneal Fluid Analysis Related tests: Pleural Fluid Analysis , Pericardial Fluid Analysis , ...

  11. Direct Numerical Simulation of Complex Multi-Fluid Flows Using a Combined Volume of Fluid and Immersed Boundary Method

    NARCIS (Netherlands)

    Deen, Niels G.; Sint Annaland, van Martin; Kuipers, J.A.M.

    2007-01-01

    In this paper a simulation model is presented for the Direct Numerical Simulation (DNS) of complex multi-fluid flows in which simultaneously (moving) deformable (drops or bubbles) and non-deformable (moving) elements (particles) are present, possibly with the additional presence of free surfaces. Ou

  12. Theory of Volumetric Moving Dislocation in Poroelastic Halfspace and Characterization of Magma Intrusion Events

    Institute of Scientific and Technical Information of China (English)

    Ouyang Zhihua; Elsworth Derek; Sheng Jianlong

    2005-01-01

    The undrained change in pore fluid pressure that accompanies dike intrusion may be conveniently represented as a moving volumetric dislocation. The concept of a dilation center was developed to represent the field of undrained pressure change in a saturated linear elastic medium. Since instantaneous pore fluid pressures can be developed to a considerable distance from the dislocation, monitoring the rate of pressure generation and subsequent pressure dissipation in a fully coupled manner enables certain characteristics of the resulting dislocation to be defined. The principal focus of this study is the application of dislocation-based methods to analyze the behavior of the fluid pressure response induced by intrusive dislocations in a semi-infinite space, such as dike intrusion, hydraulic fracturing and piezometer insertion. Partially drained pore pressures result from the isothermal introduction of volumetric moving pencil-like dislocations described as analogs to moving point dislocation within a semi-infinite saturated elastic medium. To represent behavior within the halfspace, an image dislocation is positioned under the moving coordinate frame fixed to the front of the primary moving dislocation, to yield an approximate solution for pore pressure for constant fluid pressure conditions. Induced pore pressures are concisely described under a minimum set of dimensionless parameter groupings representing propagation velocity, and relative geometry. Charts defining induced pore fluid pressure at a static measuring point provide a meaningful tool for determining unknown parameters in data reduction. Two intrusive events at Krafla, Iceland are examined using the type curve matching techniques. Predicted parameters agree favorably with field data.

  13. Holographic Fluids with Vorticity and Analogue Gravity

    CERN Document Server

    Leigh, Robert G; Petropoulos, P Marios

    2012-01-01

    We study holographic three-dimensional fluids with vorticity in local equilibrium and discuss their relevance to analogue gravity systems. The Fefferman-Graham expansion leads to the fluid's description in terms of a comoving and rotating Papapetrou-Randers frame. A suitable Lorentz transformation brings the fluid to the non-inertial Zermelo frame, which clarifies its interpretation as moving media for light/sound propagation. We apply our general results to the Lorentzian Kerr-AdS_4 and Taub-NUT-AdS_4 geometries that describe fluids in cyclonic and vortex flows respectively. In the latter case we associate the appearance of closed timelike curves to analogue optical horizons. In addition, we derive the classical rotational Hall viscosity of three-dimensional fluids with vorticity. Our formula remarkably resembles the corresponding result in magnetized plasmas.

  14. Bridging the gaps in systems biology

    OpenAIRE

    Marija Cvijovic; Joachim Almquist; Jonas Hagmar; Stefan Hohmann; Hans\\u2011Michael Kaltenbach; Edda Klipp; Marcus Krantz; Pedro Mendes; Sven Nelander; Jens Nielsen; Andrea Pagnani; Natasa Przulj; Andreas Raue; J\\xf6rg Stelling; Szymon Stoma

    2014-01-01

    International audience Systems biology aims at creating mathematical models, i.e., computational reconstructions of biological systems and processes that will result in a new level of understanding-the elucidation of the basic and presumably conserved "design" and "engineering" principles of biomolecular systems. Thus, systems biology will move biology from a phenomenological to a predictive science. Mathematical modeling of biological networks and processes has already greatly improved ou...

  15. Improving the structure MCMC sampler for Bayesian networks by introducing a new edge reversal move

    NARCIS (Netherlands)

    Grzegorczyk, Marco; Husmeier, Dirk

    2008-01-01

    Applications of Bayesian networks in systems biology are computationally demanding due to the large number of model parameters. Conventional MCMC schemes based on proposal moves in structure space tend to be too slow in mixing and convergence, and have recently been superseded by proposal moves in t

  16. 2002 in the MOVES Institute

    OpenAIRE

    Zyda, Michael

    2002-01-01

    The MOVES Institute’s mission is research, application, and education in the grand challenges of modeling, virtual environments, and simulation. Our specialties are 3D visual simulation, networked virtual environments, computer-generated autonomy, human-performance engineering, immersive technologies, defense/entertainment collaboration, and evolving operational modeling.

  17. An Improved Moving Mesh Algorithm

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    we consider an iterative algorithm of mesh optimization for finite element solution, and give an improved moving mesh strategy that reduces rapidly the complexity and cost of solving variational problems.A numerical result is presented for a 2-dimensional problem by the improved algorithm.

  18. Carlson Wagonlit Travel is moving

    CERN Multimedia

    2013-01-01

    The renovation of the Main Building continues!   Because of this, Carlson Wagonlit Travel will move from building 62 to building 510 on 4 October and the agency will be closed in the afternoon. An emergency service will be organised for official travels only. Phone: 022 799 75 73 & 022 799 75 78 / e-mail: cern@carlsonwagonlit.ch

  19. Moving ring reactor 'Karin-1'

    International Nuclear Information System (INIS)

    The conceptual design of a moving ring reactor ''Karin-1'' has been carried out to advance fusion system design, to clarify the research and development problems, and to decide their priority. In order to attain these objectives, a D-T reactor with tritium breeding blanket is designed, a commercial reactor with net power output of 500 MWe is designed, the compatibility of plasma physics with fusion engineering is demonstrated, and some other guideline is indicated. A moving ring reactor is composed mainly of three parts. In the first formation section, a plasma ring is formed and heated up to ignition temperature. The plasma ring of compact torus is transported from the formation section through the next burning section to generate fusion power. Then the plasma ring moves into the last recovery section, and the energy and particles of the plasma ring are recovered. The outline of a moving ring reactor ''Karin-1'' is described. As a candidate material for the first wall, SiC was adopted to reduce the MHD effect and to minimize the interaction with neutrons and charged particles. The thin metal lining was applied to the SiC surface to solve the problem of the compatibility with lithium blanket. Plasma physics, the engineering aspect and the items of research and development are described. (Kako, I.)

  20. Moving and Touching on Ruin

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Yes, the earthquake is a desper-ate disaster to China, but what we could see from this havoc is far more than ruin itself. Every story under the name of love touched our hearts and souls. With their moving and touching voices hovering above the seis-mic zone, let's dry our tears and do our best to rebuild the land of abundance...

  1. Coalition Hakes an Explosive Move

    Institute of Scientific and Technical Information of China (English)

    Ni Yanshuo

    2011-01-01

    @@ WHEN Rafale, Mirage 2000 and other fighter-bombers from Western coalition forces circled the Mediterranean region bound for Libya and Tomahawk cruise missiles whistled into the North African country, the world held its breath.Domestic street protests had moved to civil conflicts and foreign military operations in little over a month.

  2. Effects of fluid velocity gradients on heavy quark energy loss

    International Nuclear Information System (INIS)

    We use holographic duality to analyze the drag force on, and consequent energy loss of, a heavy quark moving through a strongly coupled conformal fluid with non-vanishing gradients in its velocity and temperature. We derive the general expression for the drag force to first order in the fluid gradients. Using this general expression, we show that a quark that is instantaneously at rest, relative to the fluid, in a fluid whose velocity is changing with time feels a nonzero force. And, we show that for a quark that is moving ultra-relativistically, the first order gradient “corrections” become larger than the zeroth order drag force, suggesting that the gradient expansion may be unreliable in this regime. We illustrate the importance of the fluid gradients for heavy quark energy loss by considering a fluid with one-dimensional boost invariant Bjorken expansion as well as the strongly coupled plasma created by colliding sheets of energy

  3. A coupled Immersed Boundary-Lattice Boltzmann method for incompressible flows through moving porous media

    Science.gov (United States)

    Pepona, Marianna; Favier, Julien

    2016-09-01

    In this work, we propose a numerical framework to simulate fluid flows in interaction with moving porous media of complex geometry. It is based on the Lattice Boltzmann method including porous effects via a Brinkman-Forchheimer-Darcy force model coupled to the Immersed Boundary method to handle complex geometries and moving structures. The coupling algorithm is described in detail and it is validated on well-established literature test cases for both stationary and moving porous configurations. The proposed method is easy to implement and efficient in terms of CPU cost and memory management compared to alternative methods which can be used to deal with moving immersed porous media, e.g. re-meshing at each time step or use of a moving/chimera mesh. An overall good agreement was obtained with reference results, opening the way to the numerical simulation of moving porous media for flow control applications.

  4. Biological Threats

    Science.gov (United States)

    ... Workplace Plans School Emergency Plans Main Content Biological Threats Biological agents are organisms or toxins that can ... for Disease Control and Prevention . Before a Biological Threat Unlike an explosion, a biological attack may or ...

  5. Gyroelastic fluids

    International Nuclear Information System (INIS)

    A study is made of a scale model in three dimensions of a guiding center plasma within the purview of gyroelastic (also known as finite gyroradius-near theta pinch) magnetohydrodynamics. The (nonlinear) system sustains a particular symmetry called isorrhopy which permits the decoupling of fluid modes from drift modes. Isorrhopic equilibria are analyzed within the framework of geometrical optics resulting in (local) dispersion relations and ray constants. A general scheme is developed to evolve an arbitrary linear perturbation of a screwpinch equilibrium as an invertible integral transform (over the complete set of generalized eigenfunctions defined naturally by the equilibrium). Details of the structure of the function space and the associated spectra are elucidated. Features of the (global) dispersion relation owing to the presence of gyroelastic stabilization are revealed. An energy principle is developed to study the stability of the tubular screwpinch

  6. Moving in a moving medium: new perspectives on flight.

    Science.gov (United States)

    Shepard, Emily L C; Ross, Andrew N; Portugal, Steven J

    2016-09-26

    One of the defining features of the aerial environment is its variability; air is almost never still. This has profound consequences for flying animals, affecting their flight stability, speed selection, energy expenditure and choice of flight path. All these factors have important implications for the ecology of flying animals, and the ecosystems they interact with, as well as providing bio-inspiration for the development of unmanned aerial vehicles. In this introduction, we touch on the factors that drive the variability in airflows, the scales of variability and the degree to which given airflows may be predictable. We then summarize how papers in this volume advance our understanding of the sensory, biomechanical, physiological and behavioural responses of animals to air flows. Overall, this provides insight into how flying animals can be so successful in this most fickle of environments.This article is part of the themed issue 'Moving in a moving medium: new perspectives on flight'.

  7. Moving in a moving medium: new perspectives on flight

    Science.gov (United States)

    Shepard, Emily L. C.; Portugal, Steven J.

    2016-01-01

    One of the defining features of the aerial environment is its variability; air is almost never still. This has profound consequences for flying animals, affecting their flight stability, speed selection, energy expenditure and choice of flight path. All these factors have important implications for the ecology of flying animals, and the ecosystems they interact with, as well as providing bio-inspiration for the development of unmanned aerial vehicles. In this introduction, we touch on the factors that drive the variability in airflows, the scales of variability and the degree to which given airflows may be predictable. We then summarize how papers in this volume advance our understanding of the sensory, biomechanical, physiological and behavioural responses of animals to air flows. Overall, this provides insight into how flying animals can be so successful in this most fickle of environments. This article is part of the themed issue ‘Moving in a moving medium: new perspectives on flight’. PMID:27528772

  8. Translating Cuba: Diasporic writing between moving cultures and moving media

    Directory of Open Access Journals (Sweden)

    Andrea Gremels

    2015-04-01

    Full Text Available This article discusses the interrelation between transculturality and transmediality with an emphasis on processes of translation. It focuses on two examples of transcultural and transmedial writing taken from contemporary Cuban literature in Paris: Miguel Sales's recontextualization of Cuban popular music in Paris and William Navarrete's ekphrastic reinscription of his island into the realm of French romantic painting. The case studies are significant in this context because they show how cultural borders are simultaneously set and transgressed at medial crossings—between music and poetry, text, and image. Thus, cultural translations go hand in hand with medial transpositions that include forms of rewriting, recomposition, and revisualization. The connection between moving cultures and moving media also points to the question of “travelling memory” in diaspora.

  9. The effect of gait on swimming in viscoelastic fluids

    CERN Document Server

    Elfring, Gwynn J

    2015-01-01

    In this paper, we give formulas for the swimming of simplified two-dimensional bodies in complex fluids using the reciprocal theorem. By way of these formulas we calculate the swimming velocity due to small-amplitude deformations on the simplest of these bodies, a two-dimensional sheet, to explore general conditions on the swimming gait under which the sheet may move faster, or slower, in a viscoelastic fluid compared to a Newtonian fluid.

  10. Research on Maneuverability of Moving Centroid Warhead

    Institute of Scientific and Technical Information of China (English)

    LIN Peng; ZHOU Feng-qi; ZHOU Jun

    2007-01-01

    The dynamic equations of the moving centroid warhead are derived, simplified and linearized, and a transfer function from moving mass displacement to normal overload of the warhead is obtained. Thus, the normal overload can be calculated when the mass moves to any different places. The research results provide a necessary theoretic reference for general design of control system of the moving centroid warhead.

  11. A Framework for Representing Moving Objects

    DEFF Research Database (Denmark)

    Becker, Ludger; Blunck, Henrik; Hinrichs, Klaus;

    2004-01-01

    We present a framework for representing the trajectories of moving objects and the time-varying results of operations on moving objects. This framework supports the realization of discrete data models of moving objects databases, which incorporate representations of moving objects based on non-li...

  12. Solving Fluid Structure Interaction Problems with an Immersed Boundary Method

    Science.gov (United States)

    Barad, Michael F.; Brehm, Christoph; Kiris, Cetin C.

    2016-01-01

    An immersed boundary method for the compressible Navier-Stokes equations can be used for moving boundary problems as well as fully coupled fluid-structure interaction is presented. The underlying Cartesian immersed boundary method of the Launch Ascent and Vehicle Aerodynamics (LAVA) framework, based on the locally stabilized immersed boundary method previously presented by the authors, is extended to account for unsteady boundary motion and coupled to linear and geometrically nonlinear structural finite element solvers. The approach is validated for moving boundary problems with prescribed body motion and fully coupled fluid structure interaction problems. Keywords: Immersed Boundary Method, Higher-Order Finite Difference Method, Fluid Structure Interaction.

  13. Investigating the fluid dynamics of rapid processes within microfluidic devices using bright-field microscopy.

    Science.gov (United States)

    Pirbodaghi, Tohid; Vigolo, Daniele; Akbari, Samin; deMello, Andrew

    2015-05-01

    The widespread application of microfluidic devices in the biological and chemical sciences requires the implementation of complex designs and geometries, which in turn leads to atypical fluid dynamic phenomena. Accordingly, a complete understanding of fluid dynamics in such systems is key in the facile engineering of novel and efficient analytical tools. Herein, we present an accurate approach for studying the fluid dynamics of rapid processes within microfluidic devices using bright-field microscopy with white light illumination and a standard high-speed camera. Specifically, we combine Ghost Particle Velocimetry and the detection of moving objects in automated video surveillance to track submicron size tracing particles via cross correlation between the speckle patterns of successive images. The efficacy of the presented technique is demonstrated by measuring the flow field over a square pillar (80 μm × 80 μm) in a 200 μm wide microchannel at high volumetric flow rates. Experimental results are in excellent agreement with those obtained via computational fluid dynamics simulations. The method is subsequently used to study the dynamics of droplet generation at a flow focusing microfluidic geometry. A unique feature of the presented technique is the ability to perform velocimetry analysis of high-speed phenomena, which is not possible using micron-resolution particle image velocimetry (μPIV) approaches based on confocal or fluorescence microscopy. PMID:25812165

  14. Meniscal Tear Film Fluid Dynamics Near Marx’s Line

    KAUST Repository

    Zubkov, V. S.

    2013-07-03

    Extensive studies have explored the dynamics of the ocular surface fluid, though theoretical investigations are typically limited to the use of the lubrication approximation, which is not guaranteed to be uniformly valid a-priori throughout the tear meniscus. However, resolving tear film behaviour within the meniscus and especially its apices is required to characterise the flow dynamics where the tear film is especially thin, and thus most susceptible to evaporatively induced hyperosmolarity and subsequent epithelial damage. Hence, we have explored the accuracy of the standard lubrication approximation for the tear film by explicit comparisons with the 2D Navier-Stokes model, considering both stationary and moving eyelids. Our results demonstrate that the lubrication model is qualitatively accurate except in the vicinity of the eyelids. In particular, and in contrast to lubrication theory, the solution of the full Navier-Stokes equations predict a distinct absence of fluid flow, and thus convective mixing in the region adjacent to the tear film contact line. These observations not only support emergent hypotheses concerning the formation of Marx\\'s line, a region of epithelial cell staining adjacent to the contact line on the eyelid, but also enhance our understanding of the pathophysiological consequences of the flow profile near the tear film contact line. © 2013 Society for Mathematical Biology.

  15. Diffuse interface simulation of ternary fluids in contact with solid

    Science.gov (United States)

    Zhang, Chun-Yu; Ding, Hang; Gao, Peng; Wu, Yan-Ling

    2016-03-01

    In this article we developed a geometrical wetting condition for diffuse-interface simulation of ternary fluid flows with moving contact lines. The wettability of the substrate in the presence of ternary fluid flows is represented by multiple contact angles, corresponding to the different material properties between the respective fluid and the substrate. Displacement of ternary fluid flows on the substrate leads to the occurrence of moving contact point, at which three moving contact lines meet. We proposed a weighted contact angle model, to replace the jump in contact angle at the contact point by a relatively smooth transition of contact angle over a region of 'diffuse contact point' of finite size. Based on this model, we extended the geometrical formulation of wetting condition for two-phase flows with moving contact lines to ternary flows with moving contact lines. Combining this wetting condition, a Navier-Stokes solver and a ternary-fluid model, we simulated two-dimensional spreading of a compound droplet on a substrate, and validated the numerical results of the drop shape at equilibrium by comparing against the analytical solution. We also checked the convergence rate of the simulation by investigating the axisymmetric drop spreading in a capillary tube. Finally, we applied the model to a variety of applications of practical importance, including impact of a circular cylinder into a pool of two layers of different fluids and sliding of a three-dimensional compound droplet in shear flows.

  16. The moving plate capacitor paradox

    Science.gov (United States)

    Davis, B. R.; Abbott, D.; Parrondo, J. M. R.

    2000-03-01

    For the first time we describe an apparent paradox concerning a moving plate capacitor driven by thermal noise from a resistor. A demon restores the plates of the capacitor to their original position, only when the voltage across the capacitor is small—hence only small forces are present for the demon to work against. The demon has to work harder than this to avoid the situation of perpetual motion, but the question is how? We explore the concept of a moving plate capacitor, driven by noise, a step further by examining the case where the restoring force on the capacitor plates is provided by a simple spring, rather than some unknown demon. We display simulation results with interesting behavior, particularly where the capacitor plates collide with each other.

  17. Moved by a Rapid Transit

    Science.gov (United States)

    Bueter, C.

    2013-04-01

    Enticing by virtue of its predictability, historical utility, and spectacle, the transit of Venus is a niche event among astronomical phenomena. Though the value of a transit for scientific purposes is now diminished, the brief appearance of Venus silhouetted against the background of the Sun in 2004 moved the artistic community to celebrate the rare alignment. Artists of all ages combined old traditions with fresh technology to create a 21st-century tapestry of music, sculpture, paintings, glasswork, quilts, sky shows, and digital imagery. A full catalog of transit-related art generated over the centuries would feature the sampling of entries presented here and at the Moved by a Rapid Transit website.

  18. Moving past sleight of hand.

    Science.gov (United States)

    Mintken, Paul E; Derosa, Carl; Little, Tamara; Smith, Britt

    2010-05-01

    Medical care historically has had a strong association with magic, illusion, and secrecy. Although we profess to be modern healthcare practitioners, utilizing manual therapy techniques, and strive for evidence-based practice, the reality is that one of the most ubiquitous of all manual therapy techniques, manipulation, is obscured by illusive and ill-defined terminology. As a first step in moving from magician to modern clinician, we recently proposed a nomenclature intended to standardize and clarify the terminology used in describing specific manual therapy techniques, recommending the use of 6 key characteristics. The persistent obfuscations appear to be aimed at obscuring the differentiation of manipulation from mobilization. The time has come for a more precise delineation between manipulation and mobilization and to move beyond seeing these valuable interventions simply as some sleight-of-hand technique.J Orthop Sports Phys Ther 2010;40(5):253-255. doi:10.2519/jospt.2010.0105.

  19. IKAR moves to higher energies

    CERN Multimedia

    1979-01-01

    The measurements of hadron elastic scattering on protons at small angle (WA9 experiment) were extended at higher energies (NA8 experiment by the Clermont Ferrand-Leningrad-Lyon-Uppsala Collaboration). To this purpose the set-up was moved to the beam H8 in the EHN1 Hall of the SPS North Area. The photo shows the ionization chamber measuring the recoil energy (centre). Pierre Sahuc stands on the left.

  20. Robotics and Biology: Lets get Physical

    Science.gov (United States)

    Choset, Howie

    Our research group investigates the core fundamentals of locomotion as it exists in biology and as it applies to locomoting robotic systems. Initially, our work advanced techniques found in geometric mechanics to design cyclic controllers, often called gaits, for snake robots, highly articulated mechanisms that can thread through tightly packed spaces to access locations people cannot. We had considerable success in designing snake robot gaits, but found our systems stymied in terrains characterized by sandy substrates. Sandy terrains and other granular media pose a challenge to snake robots because it is unclear how the mechanism interacts with environment: we cannot simply assume the robot is on hard-ground nor in a fluid. Simulating granular interactions can prove to be computationally intractable for real-time use on the robots. Therefore, we developed experimental tools that allowed us to sieve out models of the locomoting systems operating on granular media. We were then able to bring these models into harmony with the elegant formulation of our geometric mechanics approach. This allowed us to derive adaptive controllers for our snake robots in sandy terrains, and enabled us to gain deeper insight into of how biological systems move over similar terrains as well.

  1. Three-dimensional magnetic reconnection through a moving magnetic null

    Directory of Open Access Journals (Sweden)

    V. S. Lukin

    2011-11-01

    Full Text Available A computational study of three-dimensional magnetic reconnection between two flux ropes through a moving reconnection site is presented. The configuration is considered in the context of two interacting spheromaks constrained by a perfectly conducting cylindrical boundary and oriented to form a single magnetic field null at its center. The initial magnetic field configuration is embedded into a uniform thermal plasma and is unstable to tilting. As the spheromaks tilt, their magnetic fields begin to reconnect at the null, subsequently displacing both the null and the reconnection site. The motion of the reconnection region and the magnetic null are shown to be correlated, with stronger correlation and faster reconnection observed in plasmas with lower thermal to magnetic pressure ratio. It is also shown that ion inertial effects allow for yet faster reconnection, but do not qualitatively change the dynamics of the process. Implications of the coupling between moving magnetic nulls and reconnection sites, as well as of possible mechanisms for fast reconnection through a moving reconnection region, are discussed. The simulations are conducted using both single-fluid and Hall MHD plasma models within the HiFi multi-fluid modeling framework.

  2. Thermophysical Properties of Fluids and Fluid Mixtures

    Energy Technology Data Exchange (ETDEWEB)

    Sengers, Jan V.; Anisimov, Mikhail A.

    2004-05-03

    The major goal of the project was to study the effect of critical fluctuations on the thermophysical properties and phase behavior of fluids and fluid mixtures. Long-range fluctuations appear because of the presence of critical phase transitions. A global theory of critical fluctuations was developed and applied to represent thermodynamic properties and transport properties of molecular fluids and fluid mixtures. In the second phase of the project, the theory was extended to deal with critical fluctuations in complex fluids such as polymer solutions and electrolyte solutions. The theoretical predictions have been confirmed by computer simulations and by light-scattering experiments. Fluctuations in fluids in nonequilibrium states have also been investigated.

  3. Research on moving object detection based on frog's eyes

    Science.gov (United States)

    Fu, Hongwei; Li, Dongguang; Zhang, Xinyuan

    2008-12-01

    On the basis of object's information processing mechanism with frog's eyes, this paper discussed a bionic detection technology which suitable for object's information processing based on frog's vision. First, the bionics detection theory by imitating frog vision is established, it is an parallel processing mechanism which including pick-up and pretreatment of object's information, parallel separating of digital image, parallel processing, and information synthesis. The computer vision detection system is described to detect moving objects which has special color, special shape, the experiment indicates that it can scheme out the detecting result in the certain interfered background can be detected. A moving objects detection electro-model by imitating biologic vision based on frog's eyes is established, the video simulative signal is digital firstly in this system, then the digital signal is parallel separated by FPGA. IN the parallel processing, the video information can be caught, processed and displayed in the same time, the information fusion is taken by DSP HPI ports, in order to transmit the data which processed by DSP. This system can watch the bigger visual field and get higher image resolution than ordinary monitor systems. In summary, simulative experiments for edge detection of moving object with canny algorithm based on this system indicate that this system can detect the edge of moving objects in real time, the feasibility of bionic model was fully demonstrated in the engineering system, and it laid a solid foundation for the future study of detection technology by imitating biologic vision.

  4. Magnetized drive fluids

    Energy Technology Data Exchange (ETDEWEB)

    Rosensweig, R.E.; Zahn, M.

    1986-04-01

    A process is described for recovering a first fluid from a porous subterranean formation which comprises injecting a displacement fluid in an effective amount to displace the first fluid, injecting a ferrofluid, applying a magnetic field containing a gradient of field intensity within the formation, driving the displacement fluid through the formation with the ferrofluid and recovering first fluid.

  5. NUMERICAL SIMULATION OF A TWO-DIMENSIONAL SQUARE MOVING NEAR FREE SURFACE

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The body moving near the free surface is a focus in fluid dynamicresearch. Many numerical methods were developed for the simulation of the induced flow field. In this paper, a two-dimensional square moving near the free surface was simulated by the volume of fluid method (VOF). The flow field and drag exerted on the square were studied. The drag would increase due to the presence of the free surface.The iteration factor of the pressure interpolation of surface cells was modified, and through this modification the iteration became more stable. The capability of dealing with the large deformation of the free surface was raised.

  6. Fluid-driven deformation of a soft granular material

    OpenAIRE

    MacMinn, Christopher W.; Dufresne, Eric R.; Wettlaufer, John S.

    2014-01-01

    Compressing a porous, fluid-filled material will drive the interstitial fluid out of the pore space, as when squeezing water out of a kitchen sponge. Inversely, injecting fluid into a porous material can deform the solid structure, as when fracturing a shale for natural gas recovery. These poromechanical interactions play an important role in geological and biological systems across a wide range of scales, from the propagation of magma through the Earth's mantle to the transport of fluid thro...

  7. The Promises of Biology and the Biology of Promises

    DEFF Research Database (Denmark)

    Lee, Jieun

    2015-01-01

    commitments with differently imagined futures. I argue that promises are constitutive of the stem cell biology, rather than being derivative of it. Since the biological concept of stem cells is predicated on the future that they promise, the biological life of stem cells is inextricably intertwined...... patients’ bodies in anticipation of materializing the promises of stem cell biology, they are produced as a new form of biovaluable. The promises of biology move beyond the closed circuit of scientific knowledge production, and proliferate in the speculative marketplaces of promises. Part II looks at how...... of technologized biology and biological time can appear promising with the backdrop of the imagined intransigence of social, political, and economic order in the Korean society....

  8. Synovial fluid analysis

    Science.gov (United States)

    Joint fluid analysis; Joint fluid aspiration ... El-Gabalawy HS. Synovial fluid analysis, synovial biopsy, and synovial pathology. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelly's Textbook of ...

  9. Simulated body fluid immersion method for assessing biological characteristics of calcium citrate%模拟体液浸泡法评价柠檬酸钙的生物学特性

    Institute of Scientific and Technical Information of China (English)

    丁秀明; 彭磊; 文峰; 谭昭伟; 牟忠林

    2013-01-01

    . OBJECTIVE:To prepare calcium citrate biomaterials with a novel formulation based on the natural bio-mineralized oyster shel s and citric acid so as to expect to get a good application in fracture healing repair. METHODS:Crushing, grinding, and chemical reaction methods were used for refinement. Particle size analyzer, X-ray diffraction, scanning electron microscope, and Fourier transform infrared spectroscopy were adopted for analysis of the size distribution, composition, mineral phases, and micro-morphology. Biological characteristics were evaluated through a simulated body fluid experiment. RESULTS AND CONCLUSION:Oyster shel powder was reacted with saturated citric acid to produce the calcium citrate material that had uniform crystal structure and compact bonding among crystal bodies, and exhibited a certain mechanical ability. The calcium citrate material had a good crystal structure that was conductive to prolong the degradation time. The calcium citrate released calcium ions slowly, and did not produce dramatic changes in the pH value (7.20-7.46) of the surrounding in the dissolution process. With the gradual degradation of calcium citrate materials, Ca2+concentration in solution increased gradual y and stably, and ultimately achieved an appropriate concentration of 7 mmol/L, suitable for osteoblast proliferation and differentiation. Calcium citrate prepared using natural oyster shel has good biological properties, and exhibits a natural superiority to artificial bone materials.

  10. Moving least-squares corrections for smoothed particle hydrodynamics

    Directory of Open Access Journals (Sweden)

    Ciro Del Negro

    2011-12-01

    Full Text Available First-order moving least-squares are typically used in conjunction with smoothed particle hydrodynamics in the form of post-processing filters for density fields, to smooth out noise that develops in most applications of smoothed particle hydrodynamics. We show how an approach based on higher-order moving least-squares can be used to correct some of the main limitations in gradient and second-order derivative computation in classic smoothed particle hydrodynamics formulations. With a small increase in computational cost, we manage to achieve smooth density distributions without the need for post-processing and with higher accuracy in the computation of the viscous term of the Navier–Stokes equations, thereby reducing the formation of spurious shockwaves or other streaming effects in the evolution of fluid flow. Numerical tests on a classic two-dimensional dam-break problem confirm the improvement of the new approach.

  11. Numerical Simulation of Wave Interaction with Moving Net Structures

    DEFF Research Database (Denmark)

    Chen, Hao; Christensen, Erik Damgaard

    2015-01-01

    Fluid structure interaction is an important issue in designof many engineering systems including offshore fish cages. As a first step to develop a coupled CFD/FEM model, in the present study a moving porous media model has been developed in the open source library Open FOAM. The net structure was...... described as a sheet of porous media with prescribed rigid body motion and mesh motion was incorporated to conform the motion of the net. Free surface wave generation and absorption framework was also introduced to simulate wave interaction with moving net structures. The results showed that mesh motion...... solver was coupled with free surface wave generation and absorption framework and porous media model flawlessly, and the deformed mesh remained acceptable. It was concluded that Laplace mesh motionsolver with inversed quadratic diffusivity model was an appropriate option for simulating wave interaction...

  12. Superconfinement tailors fluid flow at microscales

    Science.gov (United States)

    Setu, Siti Aminah; Dullens, Roel P.A.; Hernández-Machado, Aurora; Pagonabarraga, Ignacio; Aarts, Dirk G.A.L.; Ledesma-Aguilar, Rodrigo

    2015-01-01

    Understanding fluid dynamics under extreme confinement, where device and intrinsic fluid length scales become comparable, is essential to successfully develop the coming generations of fluidic devices. Here we report measurements of advancing fluid fronts in such a regime, which we dub superconfinement. We find that the strong coupling between contact-line friction and geometric confinement gives rise to a new stability regime where the maximum speed for a stable moving front exhibits a distinctive response to changes in the bounding geometry. Unstable fronts develop into drop-emitting jets controlled by thermal fluctuations. Numerical simulations reveal that the dynamics in superconfined systems is dominated by interfacial forces. Henceforth, we present a theory that quantifies our experiments in terms of the relevant interfacial length scale, which in our system is the intrinsic contact-line slip length. Our findings show that length-scale overlap can be used as a new fluid-control mechanism in strongly confined systems. PMID:26073752

  13. Superconfinement tailors fluid flow at microscales.

    KAUST Repository

    Setu, Siti Aminah

    2015-06-15

    Understanding fluid dynamics under extreme confinement, where device and intrinsic fluid length scales become comparable, is essential to successfully develop the coming generations of fluidic devices. Here we report measurements of advancing fluid fronts in such a regime, which we dub superconfinement. We find that the strong coupling between contact-line friction and geometric confinement gives rise to a new stability regime where the maximum speed for a stable moving front exhibits a distinctive response to changes in the bounding geometry. Unstable fronts develop into drop-emitting jets controlled by thermal fluctuations. Numerical simulations reveal that the dynamics in superconfined systems is dominated by interfacial forces. Henceforth, we present a theory that quantifies our experiments in terms of the relevant interfacial length scale, which in our system is the intrinsic contact-line slip length. Our findings show that length-scale overlap can be used as a new fluid-control mechanism in strongly confined systems.

  14. Dark matter. A light move

    Energy Technology Data Exchange (ETDEWEB)

    Redondo, Javier [Muenchen Univ. (Germany). Arnold Sommerfeld Center; Max-Planck-Institut fuer Physik, Muenchen (Germany); Doebrich, Babette [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany)

    2013-11-15

    This proceedings contribution reports from the workshop Dark Matter - a light move, held at DESY in Hamburg in June 2013. Dark Matter particle candidates span a huge parameter range. In particular, well motivated candidates exist also in the sub-eV mass region, for example the axion. Whilst a plethora of searches for rather heavy Dark Matter particles exists, there are only very few experiments aimed at direct detection of sub-eV Dark Matter to this date. The aim of our workshop was to discuss if and how this could be changed in the near future.

  15. Moving Walkways, Escalators, and Elevators

    CERN Document Server

    Cardinal, J; Hurtado, F; Langerman, S; Palop, B

    2007-01-01

    We study a simple geometric model of transportation facility that consists of two points between which the travel speed is high. This elementary definition can model shuttle services, tunnels, bridges, teleportation devices, escalators or moving walkways. The travel time between a pair of points is defined as a time distance, in such a way that a customer uses the transportation facility only if it is helpful. We give algorithms for finding the optimal location of such a transportation facility, where optimality is defined with respect to the maximum travel time between two points in a given set.

  16. Lubrication approximation for micro-particles moving along parallel walls

    CERN Document Server

    Ekiel-Jezewska, M L; Blawzdziewicz, J; Feuillebois, F

    2008-01-01

    Lubrication expressions for the friction coefficients of a spherical particle moving in a fluid between and along two parallel solid walls are explicitly evaluated in the low-Reynolds-number regime. They are used to determine lubrication expression for the particle free motion under an ambient Poiseuille flow. The range of validity and the accuracy of the lubrication approximation is determined by comparing with the corresponding results of the accurate multipole procedure. The results are applicable for thin, wide and long microchannels, or quasi-two-dimensional systems.

  17. GAIA: A 2-D Curvilinear moving grid hydrodynamic code

    International Nuclear Information System (INIS)

    The GAIA computer code is developed for time dependent, compressible, multimaterial fluid flow problems, to overcome some drawbacks of traditional 2-D Lagrangian codes. The initial goals of robustness, entropy accuracies, efficiency in presence of large interfacial slip, have already been achieved. The general GODUNOV approach is applied to an arbitrary time varying control-volume formulation. We review in this paper the Riemann solver, the GODUNOV cartesian and curvilinear moving grid schemes and an efficient grid generation algorithm. We finally outline a possible second order accuracy extension

  18. Autonomous Landing on Moving Platforms

    KAUST Repository

    Mendoza Chavez, Gilberto

    2016-08-01

    This thesis investigates autonomous landing of a micro air vehicle (MAV) on a nonstationary ground platform. Unmanned aerial vehicles (UAVs) and micro air vehicles (MAVs) are becoming every day more ubiquitous. Nonetheless, many applications still require specialized human pilots or supervisors. Current research is focusing on augmenting the scope of tasks that these vehicles are able to accomplish autonomously. Precise autonomous landing on moving platforms is essential for self-deployment and recovery of MAVs, but it remains a challenging task for both autonomous and piloted vehicles. Model Predictive Control (MPC) is a widely used and effective scheme to control constrained systems. One of its variants, output-feedback tube-based MPC, ensures robust stability for systems with bounded disturbances under system state reconstruction. This thesis proposes a MAV control strategy based on this variant of MPC to perform rapid and precise autonomous landing on moving targets whose nominal (uncommitted) trajectory and velocity are slowly varying. The proposed approach is demonstrated on an experimental setup.

  19. Senior Living: Staying Positive and Moving Forward

    Science.gov (United States)

    ... Issues Feature: Senior Living Staying Positive and Moving Forward Past Issues / Summer 2009 Table of Contents For ... Living / Long Distance Caregiving / Staying Positive and Moving Forward / Former WWII Fighter Pilot Finds New Home Near ...

  20. Amodal completion of moving objects by pigeons

    OpenAIRE

    Nagasaka, Yasuo; Wasserman, Edward A.

    2008-01-01

    In a series of four experiments, we explored whether pigeons complete partially occluded moving shapes. Four pigeons were trained to discriminate between a complete moving shape and an incomplete moving shape in a two-alternative forced-choice task. In testing, the birds were presented with a partially occluded moving shape. In Experiment 1, none of the pigeons appeared to complete the testing stimulus; instead, they appeared to perceive the testing stimulus as incomplete fragments. However, ...

  1. CIRCULATING MOVING BED COMBUSTION PROOF OF CONCEPT

    Energy Technology Data Exchange (ETDEWEB)

    Jukkola, Glen

    2010-06-30

    Circulating Moving Bed (CMB) combustion technology has its roots in traditional circulating fluidized bed technology and involves a novel method of solid fuel combustion and heat transfer. CMB technology represents a step change in improved performance and cost relative to conventional PC and FBC boilers. The CMB heat exchanger preheats the energy cycle working fluid, steam or air, to the high temperature levels required in systems for advanced power generation. Unique features of the CMB are the reduction of the heat transfer surfaces by about 60% as a result of the enhanced heat transfer rates, flexibility of operation, and about 30% lower cost over existing technology. The CMB Phase I project ran from July 2001 through March 2003. Its objective was to continue development of the CMB technology with a series of proof of concept tests. The tests were conducted at a scale that provided design data for scale up to a demonstration plant. These objectives were met by conducting a series of experiments in ALSTOM Power’s Multi-use Test Facility (MTF). The MTF was modified to operate under CMB conditions of commercial interest. The objective of the tests were to evaluate gas-to-solids heat transfer in the upper furnace, assess agglomeration in the high temperature CMB bubbling bed, and evaluate solids-to-tube heat transfer in the moving bed heat exchanger. The Phase I program results showed that there are still some significant technical uncertainties that needed to be resolved before the technology can be confidently scaled up for a successful demonstration plant design. Work remained in three primary areas: • scale up of gas to solid heat transfer • high temperature finned surface design • the overall requirements of mechanical and process design. The CMB Phase II workscope built upon the results of Phase I and specifically addressed the remaining technical uncertainties. It included a scaled MTF heat transfer test to provide the necessary data to scale up gas

  2. An Introduction to Thermal-Fluid Engineering

    Science.gov (United States)

    Warhaft, Zellman

    1998-01-01

    This text is the first to provide an integrated introduction to basic engineering topics and the social implications of engineering practice. Aimed at beginning engineering students, the book presents the basic ideas of thermodynamics, fluid mechanics, heat transfer, and combustion through a real-world engineering situation. It relates the engine to the atmosphere in which it moves and exhausts its waste products. The book also discusses the greenhouse effect and atmospheric inversions, and the social implications of engineering in a crowded world with increasing energy demands. Students in mechanical, civil, agricultural, environmental, aerospace, and chemical engineering will welcome this engaging, well-illustrated introduction to thermal-fluid engineering.

  3. FLUID EXCHANGE ACROSS THE EQUATORIAL FRONT

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In this paper, the cusp-shaped wave pattern (Legeckis wave) along the Equatorial Front (EF) is modeled by a meandering jet, and the motion of fluid parcels in a two-dimensional kinematic model of the meandering jet along EF is studied using Melnikov's method. Results indicated that the velocity field of the cusp-shaped wave pattern can indeed be modeled by a meandering jet; that the EF will act as a barrier to fluid exchange if there is no variability, but that it is just the variability that moves the buoy across the EF.

  4. FLUID EXCHANGE ACROSS THE EQUATORIAL FRONT

    Institute of Scientific and Technical Information of China (English)

    姜传丽; 吕建; 吴德星

    2001-01-01

    In this paper, the cusp-shaped wave pattern (Legeckis wave) along the Equatorial Front (EF) is modeled by a meandering jet, and the motion of fluid parcels in a two-dimensional kine-matic model of the meandering jet along EF is studied using Melnikov's method. Results indicated that the velocity field of the cusp-shaped wave pattern can indeed be modeled by a meandering jet; that the EF will act as a barrier to fluid exchange if there is no variability, but that it is just the variability that moves the buoy across the EF.

  5. Interfacial gauge methods for incompressible fluid dynamics.

    Science.gov (United States)

    Saye, Robert

    2016-06-01

    Designing numerical methods for incompressible fluid flow involving moving interfaces, for example, in the computational modeling of bubble dynamics, swimming organisms, or surface waves, presents challenges due to the coupling of interfacial forces with incompressibility constraints. A class of methods, denoted interfacial gauge methods, is introduced for computing solutions to the corresponding incompressible Navier-Stokes equations. These methods use a type of "gauge freedom" to reduce the numerical coupling between fluid velocity, pressure, and interface position, allowing high-order accurate numerical methods to be developed more easily. Making use of an implicit mesh discontinuous Galerkin framework, developed in tandem with this work, high-order results are demonstrated, including surface tension dynamics in which fluid velocity, pressure, and interface geometry are computed with fourth-order spatial accuracy in the maximum norm. Applications are demonstrated with two-phase fluid flow displaying fine-scaled capillary wave dynamics, rigid body fluid-structure interaction, and a fluid-jet free surface flow problem exhibiting vortex shedding induced by a type of Plateau-Rayleigh instability. The developed methods can be generalized to other types of interfacial flow and facilitate precise computation of complex fluid interface phenomena. PMID:27386567

  6. Spontaneous oscillations in simple fluid networks

    CERN Document Server

    Karst, Nathaniel J; Geddes, John B

    2013-01-01

    Nonlinear phenomena including multiple equilibria and spontaneous oscillations are common in fluid networks containing either multiple phases or constituent flows. In many systems, such behavior might be attributed to the complicated geometry of the network, the complex rheology of the constituent fluids, or, in the case of microvascular blood flow, biological control. In this paper we investigate two examples of a simple three-node fluid network containing two miscible Newtonian fluids of differing viscosities, the first modeling microvascular blood flow and the second modeling stratified laminar flow. We use a combination of analytic and numerical techniques to identify and track saddle-node and Hopf bifurcations through the large parameter space. In both models, we document sustained spontaneous oscillations and, for an experimentally relevant example of parameter analysis, investigate the sensitivity of these oscillations to changes in the viscosity contrast between the constituent fluids and the inlet fl...

  7. Rolling motion in moving droplets

    Indian Academy of Sciences (India)

    Sumesh P Thampi; Rama Govindarajan

    2015-03-01

    Drops moving on a substrate under the action of gravity display both rolling and sliding motions. The two limits of a thin sheet-like drop in sliding motion on a surface, and a spherical drop in roll, have been extensively studied. We are interested in intermediate shapes. We quantify the contribution of rolling motion for any intermediate shape, and recently obtained a universal curve for the amount of roll as a function of a shape parameter using hybrid lattice Boltzmann simulations. In this paper, we discuss the linear relationship which is expected between the Capillary and Bond numbers, and provide detailed confirmation by simulations. We also show that the viscosity of the surrounding medium can qualitatively affect dynamics. Our results provide an answer to a natural question of whether drops roll or slide on a surface and carry implications for various applications where rolling motion may or may not be preferred.

  8. Prototype moving-ring reactor

    International Nuclear Information System (INIS)

    We have completed a design of the Prototype Moving-Ring Reactor. The fusion fuel is confined in current-carrying rings of magnetically-field-reversed plasma (Compact Toroids). The plasma rings, formed by a coaxial plasma gun, undergo adiabatic magnetic compression to ignition temperature while they are being injected into the reactor's burner section. The cylindrical burner chamber is divided into three burn stations. Separator coils and a slight axial guide field gradient are used to shuttle the ignited toroids rapidly from one burn station to the next, pausing for 1/3 of the total burn time at each station. D-T-3He ice pellets refuel the rings at a rate which maintains constant radiated power

  9. The effect of groundwater fluctuations on the velocity pattern of slow-moving landslides

    NARCIS (Netherlands)

    Van Asch, T.W.J.; Malet, J.P.; Bogaard, T.A.

    2009-01-01

    Slow-moving landslides show complex mechanical and fluid interactions. They show among others non linear intrinsic viscosity of the shear zone, undrained loading effects and the generation of excess pore water pressure. The parameterization of hydrological and geomechanical factors by field and labo

  10. Two non-comoving stiff fluids in radial motion and spherical symmetry

    OpenAIRE

    Kostov, Valentin

    2008-01-01

    The problem of two stiff fluids (energy density = pressure) moving radially in spherical symmetry is treated. The metric ansatz is chosen spherically symmetric, conformally static with a multiplicative separation of variables. The first fluid is described mathematically via a massless scalar field. The coordinate system is chosen comoving with the second fluid which the separation of variables requires to be stiff too. The fluids are interacting only gravitationally and their energy momentum ...

  11. Apparent stress-strain relationships in experimental equipment where magnetorheological fluids operate under compression mode

    OpenAIRE

    Mazlan, SA; Ekreem, NB; Olabi, Abdul

    2008-01-01

    Abstract: This paper presents an experimental investigation of two different magnetorheological ( MR) fluids, namely, water-based and hydrocarbon-based MR fluids in compression mode under various applied currents. Finite element method magnetics was used to predict the magnetic field distribution inside the MR fluids generated by a coil. A test rig was constructed where the MR fluid was sandwiched between two flat surfaces. During the compression, the upper surface was moved towards the lower...

  12. Rheological flow from a die and painting on a moving solid wall

    Institute of Scientific and Technical Information of China (English)

    TANG; Zemei; HU; Wenrui

    2004-01-01

    Die swell is an important phenomenon in polymer processing, and is explained usually by rheological properties of the fluid. Because of the nonuniform of temperature distribution on the free surface of the liquid jet, the thermocapillary convection driven by surface tension gradient exists. The rheological fluid flowing out of a die and painting on a moving solid wall is studied by the numerical finite element method of a two-dimensional and unsteady model in the present paper, and both the rheological effect of a non-Newtonian fluid and the thermocapillary effect are considered. The results show that both effects will enlarge the cross-section of the fluid jet, and the rheological effect of non-Newtonian fluid dominates the process in general.

  13. Magnetic Fluids: Biomedical Applications and Magnetic Fractionation

    OpenAIRE

    Rheinländer, Thomas; Kötitz, Róman; Weitschies, Werner; Semmler, Wolfhard

    2000-01-01

    In addition to engineering applications, magnetic fluids containing magnetic nanoparticles are being increasingly applied to biomedical purposes. Besides the well established use of magnetic particles for biological separation or as contrast agents for magnetic resonance imaging, magnetic particles are also being tested for the inductive heat treatment of tumors or as markers for the quantification of biologically active substances. The properties of magnetic nanoparticles usually exhibit a b...

  14. Fundamentals of Geophysical Fluid Dynamics

    Science.gov (United States)

    McWilliams, James C.

    2006-07-01

    Earth's atmosphere and oceans exhibit complex patterns of fluid motion over a vast range of space and time scales. These patterns combine to establish the climate in response to solar radiation that is inhomogeneously absorbed by the materials comprising air, water, and land. Spontaneous, energetic variability arises from instabilities in the planetary-scale circulations, appearing in many different forms such as waves, jets, vortices, boundary layers, and turbulence. Geophysical fluid dynamics (GFD) is the science of all these types of fluid motion. This textbook is a concise and accessible introduction to GFD for intermediate to advanced students of the physics, chemistry, and/or biology of Earth's fluid environment. The book was developed from the author's many years of teaching a first-year graduate course at the University of California, Los Angeles. Readers are expected to be familiar with physics and mathematics at the level of general dynamics (mechanics) and partial differential equations. Covers the essential GFD required for atmospheric science and oceanography courses Mathematically rigorous, concise coverage of basic theory and applications to both oceans and atmospheres Author is a world expert; this book is based on the course he has taught for many years Exercises are included, with solutions available to instructors from solutions@cambridge.org

  15. Droplet motion in one-component fluids on solid substrates with wettability gradients

    KAUST Repository

    Xu, Xinpeng

    2012-05-11

    Droplet motion on solid substrates has been widely studied not only because of its importance in fundamental research but also because of its promising potentials in droplet-based devices developed for various applications in chemistry, biology, and industry. In this paper, we investigate the motion of an evaporating droplet in one-component fluids on a solid substrate with a wettability gradient. As is well known, there are two major difficulties in the continuum description of fluid flows and heat fluxes near the contact line of droplets on solid substrates, namely, the hydrodynamic (stress) singularity and thermal singularity. To model the droplet motion, we use the dynamic van der Waals theory [Phys. Rev. E 75, 036304 (2007)] for the hydrodynamic equations in the bulk region, supplemented with the boundary conditions at the fluid-solid interface. In this continuum hydrodynamic model, various physical processes involved in the droplet motion can be taken into account simultaneously, e.g., phase transitions (evaporation or condensation), capillary flows, fluid velocity slip, and substrate cooling or heating. Due to the use of the phase field method (diffuse interface method), the hydrodynamic and thermal singularities are resolved automatically. Furthermore, in the dynamic van der Waals theory, the evaporation or condensation rate at the liquid-gas interface is an outcome of the calculation rather than a prerequisite as in most of the other models proposed for evaporating droplets. Numerical results show that the droplet migrates in the direction of increasing wettability on the solid substrates. The migration velocity of the droplet is found to be proportional to the wettability gradients as predicted by Brochard [Langmuir 5, 432 (1989)]. The proportionality coefficient is found to be linearly dependent on the ratio of slip length to initial droplet radius. These results indicate that the steady migration of the droplets results from the balance between the

  16. Method and apparatus for a combination moving bed thermal treatment reactor and moving bed filter

    Energy Technology Data Exchange (ETDEWEB)

    Badger, Phillip C.; Dunn, Jr., Kenneth J.

    2015-09-01

    A moving bed gasification/thermal treatment reactor includes a geometry in which moving bed reactor particles serve as both a moving bed filter and a heat carrier to provide thermal energy for thermal treatment reactions, such that the moving bed filter and the heat carrier are one and the same to remove solid particulates or droplets generated by thermal treatment processes or injected into the moving bed filter from other sources.

  17. Biological computation

    CERN Document Server

    Lamm, Ehud

    2011-01-01

    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  18. The Telecom Lab is moving

    CERN Multimedia

    IT Department

    2009-01-01

    As of 2nd March 2009, the Telecom Lab will move to Building 58 R-017. The Telecom Lab is the central point for all support questions regarding CERN mobile phone services (provision of SIM cards, requests for modifications of subscriptions, diagnostics for mobile phone problems, etc.). The opening hours as well as the contact details for the Telecom Lab remain unchanged: New location: Building 58 R-017 Opening hours: Every week day, from 11 a.m. to 12 a.m. Phone number: 72480 Email address: labo.telecom@cern.ch This change has no impact on support requests for mobile services. Users can still submit their requests concerning mobile phone subscriptions using the usual EDH form (https://edh.cern.ch/Document/GSM). The automatic message sent to inform users of their SIM card availability will be updated to indicate the new Telecom Lab location. You can find all information related to CERN mobile phone services at the following link: http://cern.ch/gsm CS Section - IT/CS group

  19. Direct numerical simulation of complex multi-fluid flows using a combined immersed boundary (IB) and volume of fluid (VOF) approach

    NARCIS (Netherlands)

    Deen, Niels G.; Sint Annaland, van Martin; Kuipers, J.A.M.

    2006-01-01

    In this paper a simulation model is presented for the Direct Numerical Simulation (DNS) of complex multi-fluid flows in which simultaneously (moving) deformable (drops or bubbles) and non-deformable (moving) elements (particles) are present, possibly with the additional presence of free surfaces. Ou

  20. Tunable left-handed metamaterial based on electrorheological fluids

    Institute of Scientific and Technical Information of China (English)

    Yong Huang; Xiaopeng Zhao; Liansheng Wang; Chunrong Luo

    2008-01-01

    A tunable left-handed metamaterial consisting of a periodic array of the left-handed dendritic structure units infiltrated with electro-rheological fluids is demonstrated. Experimental results show that the passband can move from the original 8.50-10.60 GHz to 7.16-8.39 GHz after electrorheological fluids are infused. When adc (direct current) electric field of 666 V/mm is applied, the passband moves toward lower frequency of within 7.08-8.30 GHz. This method provides one convenient way to design adaptive metamaterials.

  1. Effect of variable viscosity on laminar convection flow of an electrically conducting fluid in uniform magnetic field

    OpenAIRE

    Chakraborty S; Borkakati A.K.

    2002-01-01

    The flow of a viscous incompressible electrically conducting fluid on a continuous moving flat plate in presence of uniform transverse magnetic field, is studied. The flat plate which is continuously moving in its own plane with a constant speed is considered to be isothermally heated. Assuming the fluid viscosity as an inverse linear function of temperature, the nature of fluid velocity and temperature in presence of uniform magnetic field are shown for changing viscosity parameter at differ...

  2. Auxillary Fluid Flowmeter

    DEFF Research Database (Denmark)

    RezaNejad Gatabi, Javad; Forouzbakhsh, Farshid; Ebrahimi Darkhaneh, Hadi;

    2010-01-01

    The Auxiliary Fluid Flow meter is proposed to measure the fluid flow of any kind in both pipes and open channels. In this kind of flow measurement, the flow of an auxiliary fluid is measured Instead of direct measurement of the main fluid flow. The auxiliary fluid is injected into the main fluid...... be chosen. The fabrication of a prototype flow meter and experimental verification of the analytical data were reported. The fabricated prototype is able to measure the velocity of the water in an open channel....

  3. A design for fluid management in space

    Science.gov (United States)

    Searby, N. E.

    1986-01-01

    Design features of a prototype generic fluid management system (FMS) for use in space are described. The FMS design is based on centrifugation of fluids in various phases, i.e., gas, liquid and solid. Fluids are pumped by positive displacement into the apex of a spinning conic chamber and migrate to the wide end, picking up rotational motion as they move. The motion separates the phases into layers so that density dependent valves at the wide end permit the phases to exit separately. Check valves permit flow in one direction only. The system was scheduled for flight testing in a Getaway Special cannister on-board a Shuttle mission early in 1986. Potential applications of the FMS system for water recycling on the Shuttle and commercial operations and closing the ecology on the Space Station and a GEO staging base are projected.

  4. 人羊水干细胞分离方法及其生物学特性研究%Isolation and Biological Characterization of Human Amniotic Fluid-derived Stem Cells

    Institute of Scientific and Technical Information of China (English)

    关婷; 谢晓砚; 刘珊玲; 陈新莲; 魏杨君; 赖怡; 谢良玉; 刘之英; 张雪梅; 刘洪倩; 张建军

    2012-01-01

    Objective To establish in vitro culture procedure for human amniotic fluid-derived CD117 positive stem cells, and to identify the characteristics of CD117 positive stem cells. Methods 86 amniotic fluid samples (10 mL of each) were obtained by second-trimester amniocentesis. Isolation of amniotic fluid-derived stem cells expressing CD117 antigen was performed via magnetic cell sorting using the CD117 MicroBead Kit. The karyotype of CD117 positive stem cells was analysed throughrepeated freezing. Adipogenic differentiation of these CD117 positive stem cells was displayed by Oil Red O staining. Osteogeneic differentiation of these CD117 positive stem cells was confirmed by Alizarin Red staining. Results The CD117 positive stem cells were successfully isolated and cultured from 61 samples, with all showing normal karyotype. Product analysis of specific staining confirmed that under specific culture mediums, these cells could be successfully induced to differentiate into adipocytes and osteocytes. Conclusion Based on this study, we estimate that isolating CD117 positive stem cells from second-trimester amniotic fluid obtained by amniocentesis has a success rate of 70. 93%. These cells maintain morphological and genetic stability in vitro. Human amniotic fluid-derived CD117 positive stem cells have the ability to differentiate in vitro into adipocytes and osteocytes under specific cuLture mediums and may be applied in cell transplantation and regenerative medicine.%目的 建立体外培养人羊水来源CD117阳性干细胞的方法,初步探讨CD117阳性干细胞的特性.方法 通过孕中期羊膜腔穿刺获得86例羊水标本.采用CD117磁珠分选表达CD117抗原的羊水干细胞.对经过反复冻存的CD117阳性干细胞进行核型分析.分别经成脂诱导和成骨诱导分化,再分别使用油红O染色、茜素红染色.结果 从61例标本中成功分离培养出CD117阳性细胞,经核型分析显示其染色体核型正常.CD117阳性细胞经

  5. Biology of Nanobots

    Science.gov (United States)

    Duan, Wentao; Pavlick, Ryan; Sen, Ayusman

    2013-12-01

    One of the more interesting recent discoveries has been the ability to design nano/microbots which catalytically harness the chemical energy in their environment to move autonomously. Their potential applications include delivery of materials, self-assembly of superstructures, and roving sensors. One emergent area of research is the study of their collective behavior and how they emulate living systems. The aim of this chapter is to describe the "biology" of nanobots, summarizing the fundamentals physics behind their motion and how the bots interact with each other to initiate complex emergent behavior.

  6. Scattering methods in complex fluids

    CERN Document Server

    Chen, Sow-Hsin

    2015-01-01

    Summarising recent research on the physics of complex liquids, this in-depth analysis examines the topic of complex liquids from a modern perspective, addressing experimental, computational and theoretical aspects of the field. Selecting only the most interesting contemporary developments in this rich field of research, the authors present multiple examples including aggregation, gel formation and glass transition, in systems undergoing percolation, at criticality, or in supercooled states. Connecting experiments and simulation with key theoretical principles, and covering numerous systems including micelles, micro-emulsions, biological systems, and cement pastes, this unique text is an invaluable resource for graduate students and researchers looking to explore and understand the expanding field of complex fluids.

  7. Complex fluids modeling and algorithms

    CERN Document Server

    Saramito, Pierre

    2016-01-01

    This book presents a comprehensive overview of the modeling of complex fluids, including many common substances, such as toothpaste, hair gel, mayonnaise, liquid foam, cement and blood, which cannot be described by Navier-Stokes equations. It also offers an up-to-date mathematical and numerical analysis of the corresponding equations, as well as several practical numerical algorithms and software solutions for the approximation of the solutions. It discusses industrial (molten plastics, forming process), geophysical (mud flows, volcanic lava, glaciers and snow avalanches), and biological (blood flows, tissues) modeling applications. This book is a valuable resource for undergraduate students and researchers in applied mathematics, mechanical engineering and physics.

  8. Modeling of movement-induced and flow-induced fluid forces in fast switching valves

    DEFF Research Database (Denmark)

    Roemer, Daniel Beck; Johansen, Per; Schmidt, Lasse;

    2015-01-01

    Fast switching fluid power valves set strict requirements on performance, size and energy efficiency and simulation models are therefore needed to obtain good designs of such components. The valve moving member is subject to fluid forces depending on the valve flow rate and movement of the valve...... is proposed, which includes both the flow-induced fluid forces and the movement-induced fluid forces resulting from movement of the valve moving member. The movement-induced fluid force model is based on a known solution to the linearized Navier-Stokes equations. A method for accurately simulating the flow......-pressure relationship of a switching valve based on CFD results is presented along with the fluid force model, to constitute a complete valve fluid model. The parameters needed for the proposed model are determined based on CFD analyses, and the process of finding these parameters are described based on a reference...

  9. Stick-Slip Motion of Moving Contact Line on Chemically Patterned Surfaces

    KAUST Repository

    Wu, Congmin

    2009-01-01

    Based on our continuum hydrodynamic model for immiscible two-phase flows at solid surfaces, the stick-slip motion has been predicted for moving contact line at chemically patterned surfaces [Wang et al., J. Fluid Mech., 605 (2008), pp. 59-78]. In this paper we show that the continuum predictions can be quantitatively verified by molecular dynamics (MD) simulations. Our MD simulations are carried out for two immiscible Lennard-Jones fluids confined by two planar solid walls in Poiseuille flow geometry. In particular, one solid surface is chemically patterned with alternating stripes. For comparison, the continuum model is numerically solved using material parameters directly measured in MD simulations. From oscillatory fluid-fluid interface to intermittent stick-slip motion of moving contact line, we have quantitative agreement between the continuum and MD results. This agreement is attributed to the accurate description down to molecular scale by the generalized Navier boundary condition in our continuum model. Numerical results are also presented for the relaxational dynamics of fluid-fluid interface, in agreement with a theoretical analysis based on the Onsager principle of minimum energy dissipation. © 2010 Global-Science Press.

  10. Amniotic fluid (image)

    Science.gov (United States)

    Amniotic fluid surrounds the growing fetus in the womb and protects the fetus from injury and temperature changes. ... of fetal movement and permits musculoskeletal development. The amniotic fluid can be withdrawn in a procedure called amniocentsis ...

  11. Peritoneal fluid culture

    Science.gov (United States)

    Culture - peritoneal fluid ... sent to the laboratory for Gram stain and culture. The sample is checked to see if bacteria ... based on more than just the peritoneal fluid culture (which may be negative even if you have ...

  12. Electric fluid pump

    Science.gov (United States)

    Van Dam, Jeremy Daniel; Turnquist, Norman Arnold; Raminosoa, Tsarafidy; Shah, Manoj Ramprasad; Shen, Xiaochun

    2015-09-29

    An electric machine is presented. The electric machine includes a hollow rotor; and a stator disposed within the hollow rotor, the stator defining a flow channel. The hollow rotor includes a first end portion defining a fluid inlet, a second end portion defining a fluid outlet; the fluid inlet, the fluid outlet, and the flow channel of the stator being configured to allow passage of a fluid from the fluid inlet to the fluid outlet via the flow channel; and wherein the hollow rotor is characterized by a largest cross-sectional area of hollow rotor, and wherein the flow channel is characterized by a smallest cross-sectional area of the flow channel, wherein the smallest cross-sectional area of the flow channel is at least about 25% of the largest cross-sectional area of the hollow rotor. An electric fluid pump and a power generation system are also presented.

  13. Understanding the Mechanisms Enabling an Ultra-high Efficiency Moving Wire Interface for Real-time Carbon 14 Accelerator Mass Spectrometry Quantitation of Samples Suspended in Solvent

    Science.gov (United States)

    Thomas, Avraham Thaler

    Carbon 14 (14C) quantitation by accelerator mass spectrometry (AMS) is a powerfully sensitive and uniquely quantitative tool for tracking labeled carbonaceous molecules in biological systems. This is due to 14C's low natural abundance of 1 ppt, the nominal difference in biological activity between an unlabeled and a 14C-labeled molecule, and the ability of AMS to measure isotopic ratios independently of a sample's other characteristics. To make AMS more broadly accessible, a moving wire interface for real-time coupling of high pressure liquid chromatography (HPLC) to AMS and high throughput AMS quantitation of minute single samples has been developed. Prior to this work, samples needed to be converted to solid carbon before measurement. This conversion process has many steps and requires that the sample size be large enough to allow precise handling of the resulting graphite. These factors make the process susceptible to error and time consuming, as well as requiring 0.5 ug of carbon. Samples which do not contain enough carbon, such as HPLC fractions, must be bulked up. This adds background and increases effort. The moving wire interface overcomes these limitations by automating sample processing. Samples placed on the wire are transported through a solvent removal stage followed by a combustion stage after which the combustion products are directed to a gas accepting ion source. The ion source converts the carbon from the CO2 combustion product into C ions, from which an isotopic ratio can be determined by AMS. Although moving wire interfaces have been implemented for various tasks since 1964, the efficiency of these systems at transferring fluid from an HPLC to the wire was only 3%, the efficiency of transferring combustion products from the combustion oven to ion source was only 30%, the flow and composition of the carrier gas from the combustion oven to the ion source needed to be optimized for coupling to an AMS gas accepting ion source and the drying ovens

  14. A fluid particle model

    OpenAIRE

    Español, Pep

    1997-01-01

    We present a mechanistic model for a Newtonian fluid called fluid particle dynamics. By analyzing the concept of ``fluid particle'' from the point of view of a Voronoi tessellation of a molecular fluid, we propose an heuristic derivation of a dissipative particle dynamics algorithm that incorporates shear forces between dissipative particles. The inclusion of these non-central shear forces requires the consideration of angular velocities of the dissipative particles in order to comply with th...

  15. Fluid Movement and Creativity

    Science.gov (United States)

    Slepian, Michael L.; Ambady, Nalini

    2012-01-01

    Cognitive scientists describe creativity as fluid thought. Drawing from findings on gesture and embodied cognition, we hypothesized that the physical experience of fluidity, relative to nonfluidity, would lead to more fluid, creative thought. Across 3 experiments, fluid arm movement led to enhanced creativity in 3 domains: creative generation,…

  16. Novel Simulated moving bed technologies

    Energy Technology Data Exchange (ETDEWEB)

    Purdue University

    2003-12-30

    Cellulose and hemicellulose from plants and other biomass can be hydrolyzed to produce sugars (i.e. glucose and xylose). Once these sugars are separated from other impurities, they can serve as feedstock in fermentation to produce ethanol (as fuels), lactic acid, or other valuable chemicals. The need for producing fuels and chemicals from renewable biomass has become abundantly clear over the last decade. However, the cost of producing fermentable sugars from biomass hydrolyzate using existing technology is relatively high and has been a major obstacle. The objective of this project is to develop an efficient and economical simulated moving bed (SMB) process to recover fermentable sugars from biomass hydrolyzate. Sulfuric acid can hydrolyze the cellulose and hemicellulose in biomass to sugars, but this process can generate byproducts such as acetic acid, and can lead to further degradation of the xylose to furfural and glucose to hydroxymethyl furfural (HMF). Also, lignin and other compounds in the biomass will degrade to various phenolic compounds. If the concentrations of these compounds exceed certain threshold levels, they will be toxic to the downstream fermentation, and will severely limit the usefulness of the derived sugars. Standard post-hydrolysis processing involves neutralization of sulfuric acid, usually with lime (calcium hydroxide). A study by Wooley et al.showed that the limed hydrolyzate gave a low ethanol yield in fermentation test (20% of theoretical yield compared to 77% of theoretical yield from fermentation of pure sugars). They showed that instead of adding lime, an ion exclusion chromatography process could be used to remove acids, as well as to isolate the sugars from the biomass hydrolyzate. In this project, we investigated the feasibility of developing an economical SMB process based on (1) a polymeric adsorbent, Dowex99, which was used by Wooley et al., (2) a second polymeric adsorbent, poly-4-vinyl pyridine (or PVP in short, Reilly

  17. A coupled Immersed Boundary – Lattice Boltzmann method for incompressible flows through moving porous media A coupled Immersed Boundary -Lattice Boltzmann method for incompressible flows through moving porous media

    OpenAIRE

    Pepona, Marianna; Favier, Julien

    2016-01-01

    International audience In this work, we propose a numerical framework to simulate fluid flows in interaction with moving porous media of complex geometry. It is based on the Lattice Boltzmann method including porous effects via a Brinkman-Forchheimer-Darcy force model coupled to the Immersed Boundary method to handle complex ge-ometries and moving structures. The coupling algorithm is described in detail and it is validated on well-established literature test cases for both stationary and ...

  18. Superresolution reconstruction for moving point target detection

    NARCIS (Netherlands)

    Dijk, J.; Eekeren, A.W.M. van; Schutte, K.; Lange, D.J.J. de; Vliet, L.J. van

    2008-01-01

    When bright moving objects are viewed with an electrooptical system at long range, they appear as small, slightly blurred moving points in the recorded image sequence. Typically, such point targets need to be detected in an early stage. However, in some scenarios the background of a scene may contai

  19. Moving core beam energy absorber and converter

    Science.gov (United States)

    Degtiarenko, Pavel V.

    2012-12-18

    A method and apparatus for the prevention of overheating of laser or particle beam impact zones through the use of a moving-in-the-coolant-flow arrangement for the energy absorbing core of the device. Moving of the core spreads the energy deposition in it in 1, 2, or 3 dimensions, thus increasing the effective cooling area of the device.

  20. Improvisation: Another Way to Move and Dance

    Science.gov (United States)

    Morgan, Rachel

    2004-01-01

    Using improvisation in movement and dance classes is an ideal way to help students relate to how their bodies move. Students can learn confidence from the way they move by experimenting with unconventional and different methods. Improvisation, as such, is responding spontaneously to stimuli (music) in order to create a composition that allows for…

  1. Theses "Discussion" Sections: A Structural Move Analysis

    Science.gov (United States)

    Nodoushan, Mohammad Ali Salmani; Khakbaz, Nafiseh

    2011-01-01

    The current study aimed at finding the probable differences between the move structure of Iranian MA graduates' thesis discussion subgenres and those of their non-Iranian counterparts, on the one hand, and those of journal paper authors, on the other. It also aimed at identifying the moves that are considered obligatory, conventional, or optional…

  2. Fluid and particle mechanics

    CERN Document Server

    Michell, S J

    2013-01-01

    Fluid and Particle Mechanics provides information pertinent to hydraulics or fluid mechanics. This book discusses the properties and behavior of liquids and gases in motion and at rest. Organized into nine chapters, this book begins with an overview of the science of fluid mechanics that is subdivided accordingly into two main branches, namely, fluid statics and fluid dynamics. This text then examines the flowmeter devices used for the measurement of flow of liquids and gases. Other chapters consider the principle of resistance in open channel flow, which is based on improper application of th

  3. Engineering fluid mechanics

    CERN Document Server

    Yamaguchi, Hiroshi

    2008-01-01

    This book is intended to serve as a unique and comprehensive textbook for scientists and engineers as well as advanced students in thermo-fluid courses. It provides an intensive monograph essential for understanding dynamics of ideal fluid, Newtonian fluid, non-Newtonian fluid and magnetic fluid. These distinct, yet intertwined subjects are addressed in an integrated manner. It starts with coherent treatment of fundamental continuum mechanics, with an emphasis on the intrinsic angular momentum, by which the concepts of ferrohydrodynamics are progressively built up, and serve as a foundation fo

  4. Development of a Photo-Fluidic Control Valve without Mechanical Moving Parts

    Science.gov (United States)

    Akagi, Tetsuya; Dohta, Shujiro

    An optical servo system is a new control system which can be used in hazardous environments; such as those with electromagnetic influence, radiation and so on. The purpose of our study is to develop such an optical control system. In our previous study, an optical servo valve in which the output differential pressure was proportional to input optical power had been developed. However, the dynamics of the valve depended on the time required to move the flapper membrane of a fluid booster amplifier using the lower flow rate from the photo-fluidic interface. In addition, the lifetime of the valve depends on that of the fluid booster amplifier that has mechanical moving parts. As a next step, we need to improve the dynamics and to get longer lifetime of the optical servo valve and try to develop another type of optical servo valve whose elements have no mechanical moving parts. In this paper, a photo-fluidic control valve which consists of the photo-fluidic interface and fluid amplifier only using fluidics is proposed. As a result, we found that the tested valve generated output differential pressure of + 80 kPa or -80 kPa according to applied optical power. By driving a pneumatic cylinder whose inner diameter is 16 mm with a stroke of 100 mm using the tested valve, we also confirmed that the tested valve has enough output fluid power to drive a small-sized pneumatic cylinder on the market.

  5. Influência do tipo de material suporte no desempenho de reatores biológicos de leito móvel na remoção de carbono e nitrificação de esgoto sanitário The influence of material support kind on the biological moving bed reactors performance used for the carbon removal and nitrification of sewage

    Directory of Open Access Journals (Sweden)

    Delmira Beatriz Wolff

    2010-06-01

    Full Text Available Neste trabalho foi mostrada a influência do tipo de material suporte: P4 (plástico reciclado rugoso, diâmetro médio de 2,31 mm, densidade de 900 kg.m-3, superfície específica potencial de 2.596 m².m-3sup e P5 (polietileno, pouco rugoso, forma cilíndrica, diâmetro médio de 10 mm, densidade de 880 kg.m-3, superfície específica potencial de 3.075m².m-³sup utilizados em dois reatores biológicos de leito móvel, fluxo contínuo, na remoção de carbono e nitrificação de esgoto sanitário, os quais foram divididos em duas fases, de acordo com a idade do lodo (IL: fase A: IL de 10 dias e fase B: IL de 3 dias. Foram aplicadas cargas orgânicas superficiais médias de 4,0 kgDQO.m-2.d-1 (P4 e de 4,1 kgDQO.m-2.d-1 (P5; e cargas superficiais de nitrogênio de 0,63 kgN.m-2.d-1 (P5 e de 0,66 kgN.m-2.d-1 (P5. Para o material P4, a remoção média foi de 87% de carbono e 83% de nitrogênio (fase A e 80% de carbono e 77% de nitrogênio (fase B. Para o P5, remoção de 63% de carbono e 55% de nitrogênio (Fase A e 59% de carbono e de nitrogênio (fase B. Com base nos resultados obtidos, verificou-se que a remoção de carbono e nitrogênio não foi influenciada pela idade do lodo, mas pelo tipo de material suporte (forma ou características de superfície e superfície disponível para o crescimento da biomassa.This paper presented the influence of material support kind: P4 (rugous recycled plastic, medium diameter of 2.31 mm, density of 900 kg.m-3, specific surface potential of 2,596 m².m-3sup and P5 (polietilene, cilindric shape, medium diameter of 10 mm, density of 880 kg.m-3, specific surface potential of 3,075m².m-3sup used in two continuous flux biological moving bed reactors using different material support to remove nitrogen and carbon from sewage, which was divided in two phases according to sludge retention time (SRT: phase A: SRT of 10 days and phase B: SRT of 3 days. The organic loading rates applied were 4.0 kgCOD.m-2.d-1 (P4 and

  6. Membrane fluids and Dirac membrane fluids

    CERN Document Server

    Ivanov, M G

    2004-01-01

    The relation between two different methods of membrane fluid description is clarified by construction of combined method. Dirac membrane field appears naturally in new approach. It provides a possibility to consider new aspects of electrodynamics-type theories with electric and magnetic sources. The membrane fluid models automatically prohibit simulatenos existence of electric and magnetic currents. Possible applications to the dark energy problem are mentioned.

  7. Modeling and simulation of dust behaviors behind a moving vehicle

    Science.gov (United States)

    Wang, Jingfang

    Simulation of physically realistic complex dust behaviors is a difficult and attractive problem in computer graphics. A fast, interactive and visually convincing model of dust behaviors behind moving vehicles is very useful in computer simulation, training, education, art, advertising, and entertainment. In my dissertation, an experimental interactive system has been implemented for the simulation of dust behaviors behind moving vehicles. The system includes physically-based models, particle systems, rendering engines and graphical user interface (GUI). I have employed several vehicle models including tanks, cars, and jeeps to test and simulate in different scenarios and conditions. Calm weather, winding condition, vehicle turning left or right, and vehicle simulation controlled by users from the GUI are all included. I have also tested the factors which play against the physical behaviors and graphics appearances of the dust particles through GUI or off-line scripts. The simulations are done on a Silicon Graphics Octane station. The animation of dust behaviors is achieved by physically-based modeling and simulation. The flow around a moving vehicle is modeled using computational fluid dynamics (CFD) techniques. I implement a primitive variable and pressure-correction approach to solve the three dimensional incompressible Navier Stokes equations in a volume covering the moving vehicle. An alternating- direction implicit (ADI) method is used for the solution of the momentum equations, with a successive-over- relaxation (SOR) method for the solution of the Poisson pressure equation. Boundary conditions are defined and simplified according to their dynamic properties. The dust particle dynamics is modeled using particle systems, statistics, and procedure modeling techniques. Graphics and real-time simulation techniques, such as dynamics synchronization, motion blur, blending, and clipping have been employed in the rendering to achieve realistic appearing dust

  8. Spinning fluids reactor

    Science.gov (United States)

    Miller, Jan D; Hupka, Jan; Aranowski, Robert

    2012-11-20

    A spinning fluids reactor, includes a reactor body (24) having a circular cross-section and a fluid contactor screen (26) within the reactor body (24). The fluid contactor screen (26) having a plurality of apertures and a circular cross-section concentric with the reactor body (24) for a length thus forming an inner volume (28) bound by the fluid contactor screen (26) and an outer volume (30) bound by the reactor body (24) and the fluid contactor screen (26). A primary inlet (20) can be operatively connected to the reactor body (24) and can be configured to produce flow-through first spinning flow of a first fluid within the inner volume (28). A secondary inlet (22) can similarly be operatively connected to the reactor body (24) and can be configured to produce a second flow of a second fluid within the outer volume (30) which is optionally spinning.

  9. Fluid cooled electrical assembly

    Science.gov (United States)

    Rinehart, Lawrence E.; Romero, Guillermo L.

    2007-02-06

    A heat producing, fluid cooled assembly that includes a housing made of liquid-impermeable material, which defines a fluid inlet and a fluid outlet and an opening. Also included is an electrical package having a set of semiconductor electrical devices supported on a substrate and the second major surface is a heat sink adapted to express heat generated from the electrical apparatus and wherein the second major surface defines a rim that is fit to the opening. Further, the housing is constructed so that as fluid travels from the fluid inlet to the fluid outlet it is constrained to flow past the opening thereby placing the fluid in contact with the heat sink.

  10. Computational methods for fluid dynamics

    CERN Document Server

    Ferziger, Joel H

    2002-01-01

    In its 3rd revised and extended edition the book offers an overview of the techniques used to solve problems in fluid mechanics on computers and describes in detail those most often used in practice. Included are advanced methods in computational fluid dynamics, like direct and large-eddy simulation of turbulence, multigrid methods, parallel computing, moving grids, structured, block-structured and unstructured boundary-fitted grids, free surface flows. The 3rd edition contains a new section dealing with grid quality and an extended description of discretization methods. The book shows common roots and basic principles for many different methods. The book also contains a great deal of practical advice for code developers and users, it is designed to be equally useful to beginners and experts. The issues of numerical accuracy, estimation and reduction of numerical errors are dealt with in detail, with many examples. A full-feature user-friendly demo-version of a commercial CFD software has been added, which ca...

  11. Real-time detection of moving objects in a dynamic scene from moving robotic vehicles

    Science.gov (United States)

    Ansar, A.; Talukder, S.; Goldberg, L.; Matthies, A.

    2003-01-01

    Dynamic scene perception is currently limited to detection of moving objects from a static platform or scenes with flat backgrounds. We discuss novel methods to segment moving objects in the motion field formed by a moving camera/robotic platform in real time.

  12. Moving Matters: The Causal Effect of Moving Schools on Student Performance. Working Paper #01-15

    Science.gov (United States)

    Schwartz, Amy Ellen; Stiefel, Leanna; Cordes, Sarah A.

    2015-01-01

    The majority of existing research on mobility indicates that students do worse in the year of a school move. This research, however, has been unsuccessful in isolating the causal effects of mobility and often fails to distinguish the heterogeneous impacts of moves, conflating structural moves (mandated by a school's terminal grade) and…

  13. 77 FR 16566 - Submission for OMB Review, Comment Request, Proposed Collection: Let's Move Museums, Let's Move...

    Science.gov (United States)

    2012-03-21

    ... Museums, Let's Move Gardens collection was published in the Federal Register on November 16, 2011 (FR vol... Move Museums, Let's Move Gardens AGENCY: Institute of Museum and Library Services, The National... Institute of Museum and Library Services announces that the following information collection has...

  14. Rheological effect on thermocapillary flow of a liquid film jet painted on a moving boundary

    Institute of Scientific and Technical Information of China (English)

    HU; Wenrui(胡文瑞); HUI; W.H.(许为厚)

    2002-01-01

    In the present paper, a liquid (or melt) film of relatively high temperature ejected from a vessel and painted on the moving solid film is analyzed by using the second-order fluid model of the non-Newtonian fluid. The thermocapillary flow driven by the temperature gradient on the free surface of a Newtonian liquid film was discussed before. The effect of rheological fluid on thermocapillary flow is considered in the present paper. The analysis is based on the approximations of lubrication theory and perturbation theory. The equation of liquid height and the process of thermal hydrodynamics of the non-Newtonian liquid film are obtained, and the case of weak effect of the rheological fluid is solved in detail.

  15. Development of a permeability-limited model of the human brain and cerebrospinal fluid (CSF) to integrate known physiological and biological knowledge: Estimating time varying CSF drug concentrations and their variability using in vitro data.

    Science.gov (United States)

    Gaohua, Lu; Neuhoff, Sibylle; Johnson, Trevor N; Rostami-Hodjegan, Amin; Jamei, Masoud

    2016-06-01

    A 4-compartment permeability-limited brain (4Brain) model consisting of brain blood, brain mass, cranial and spinal cerebrospinal fluid (CSF) compartments has been developed and incorporated into a whole body physiologically-based pharmacokinetic (PBPK) model within the Simcyp Simulator. The model assumptions, structure, governing equations and system parameters are described. The model in particular considers the anatomy and physiology of the brain and CSF, including CSF secretion, circulation and absorption, as well as the function of various efflux and uptake transporters existing on the blood-brain barrier (BBB) and blood-CSF barrier (BCSFB), together with the known parameter variability. The model performance was verified using in vitro data and clinical observations for paracetamol and phenytoin. The simulated paracetamol spinal CSF concentration is comparable with clinical lumbar CSF data for both intravenous and oral doses. Phenytoin CSF concentration-time profiles in epileptic patients were simulated after accounting for disease-induced over-expression of efflux transporters within the BBB. Various 'what-if' scenarios, involving variation of specific drug and system parameters of the model, demonstrated that the 4Brain model is able to simulate the possible impact of transporter-mediated drug-drug interactions, the lumbar puncture process and the age-dependent change in the CSF turnover rate on the local PK within the brain. PMID:27236639

  16. MHD visco elastic boundary layer flow with free convention past a continuous moving surface

    International Nuclear Information System (INIS)

    The behaviour of free convective boundary layer flow of an electrically conducting, viscoelastic, incompressible fluid over a continuously moving flat surface in presence of uniform magnetic field with constant suction is studied in this section. A uniform magnetic field is assumed to be applied perpendicular to the moving flat surface. The velocity and temperature field are obtained. The effect of R (small Reynold's number), M (Hartmann number), G (Grashoff number) and Ko (visco-elastic parameter) on velocity field and temperature field are discussed with the help of graphs. (author)

  17. DEGRADATION OF AROMATIC COMPOUNDS USING MOVING BED BIOFILM REACTORS

    Directory of Open Access Journals (Sweden)

    B. Ayati, H. Ganjidoust, M. Mir Fattah

    2007-04-01

    Full Text Available For biological treatment of water, there are many different biofilm systems in use. Examples of them are trickling filters, rotating biological contactors, fixed media submerged biofilters, granular media biofilters and fluidized bed reactors. They all have their advantages and disadvantages. Hence, the Moving Bed Biofilm Reactor process was developed in Norway in the late 1980s and early 1990s to adopt the best features of the activated sludge process as well as those of the biofilter processes, without including the worst. Two cylindrical moving bed biofilm reactors were used in this study working in upflow stream conditions. Experiments have been done in aerobic batch flow regime. Laboratory experiments were conducted at room temperature (23–28C and synthetic wastewater comprising a composition of phenol and hydroquinone in each reactor as the main organic constituents, plus balanced nutrients and alkalinity were used to feed the reactor. The ratio of influent to effluent COD was determined at different retention times. The results indicated that the removal efficiency of each selected compound is affected by the detention time. At low phenol and hydroquinone concentration (from 700 to 1000 mg/L maximum removal efficiency (over 80 % was obtained. By further increasing in COD loading rate up to 3000 mg/L, a decrease in COD removal rate was occurred. In the reactor containing pyrogallol in COD of 1500 mg/L, the removal rate decreased to 10 percent because of its toxicity for microorganisms.

  18. Biological scaling and physics

    Indian Academy of Sciences (India)

    A R P Rau

    2002-09-01

    Kleiber’s law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as -1/4 in terms of the mass of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  19. Biological scaling and physics.

    Science.gov (United States)

    Rau, A R P

    2002-09-01

    Kleiber's law in biology states that the specific metabolic rate (metabolic rate per unit mass) scales as M- 1/4 in terms of the mass M of the organism. A long-standing puzzle is the (- 1/4) power in place of the usual expectation of (- 1/3) based on the surface to volume ratio in three-dimensions. While recent papers by physicists have focused exclusively on geometry in attempting to explain the puzzle, we consider here a specific law of physics that governs fluid flow to show how the (- 1/4) power arises under certain conditions. More generally, such a line of approach that identifies a specific physical law as involved and then examines the implications of a power law may illuminate better the role of physics in biology.

  20. Performance Simulations of Moving Target Search Algorithms

    Directory of Open Access Journals (Sweden)

    Peter K. K. Loh

    2009-01-01

    Full Text Available The design of appropriate moving target search (MTS algorithms for computer-generated bots poses serious challenges as they have to satisfy stringent requirements that include computation and execution efficiency. In this paper, we investigate the performance and behaviour of existing moving target search algorithms when applied to search-and-capture gaming scenarios. As part of the investigation, we also introduce a novel algorithm known as abstraction MTS. We conduct performance simulations with a game bot and moving target within randomly generated mazes of increasing sizes and reveal that abstraction MTS exhibits competitive performance even with large problem spaces.

  1. Fixing the shadows while moving the gnomon

    OpenAIRE

    Gangui, Alejandro

    2016-01-01

    It is a common practice to fix a vertical gnomon and study the moving shadow cast by it. This shows our local solar time and gives us a hint regarding the season in which we perform the observation. The moving shadow can also tell us our latitude with high precision. In this paper we propose to exchange the roles and while keeping the shadows fixed on the ground we will move the gnomon. This lets us understand in a simple way the relevance of the tropical lines of latitude and the behavior of...

  2. Is synthetic biology mechanical biology?

    Science.gov (United States)

    Holm, Sune

    2015-12-01

    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  3. Shear waves in inhomogeneous, compressible fluids in a gravity field.

    Science.gov (United States)

    Godin, Oleg A

    2014-03-01

    While elastic solids support compressional and shear waves, waves in ideal compressible fluids are usually thought of as compressional waves. Here, a class of acoustic-gravity waves is studied in which the dilatation is identically zero, and the pressure and density remain constant in each fluid particle. These shear waves are described by an exact analytic solution of linearized hydrodynamics equations in inhomogeneous, quiescent, inviscid, compressible fluids with piecewise continuous parameters in a uniform gravity field. It is demonstrated that the shear acoustic-gravity waves also can be supported by moving fluids as well as quiescent, viscous fluids with and without thermal conductivity. Excitation of a shear-wave normal mode by a point source and the normal mode distortion in realistic environmental models are considered. The shear acoustic-gravity waves are likely to play a significant role in coupling wave processes in the ocean and atmosphere.

  4. Shear waves in inhomogeneous, compressible fluids in a gravity field.

    Science.gov (United States)

    Godin, Oleg A

    2014-03-01

    While elastic solids support compressional and shear waves, waves in ideal compressible fluids are usually thought of as compressional waves. Here, a class of acoustic-gravity waves is studied in which the dilatation is identically zero, and the pressure and density remain constant in each fluid particle. These shear waves are described by an exact analytic solution of linearized hydrodynamics equations in inhomogeneous, quiescent, inviscid, compressible fluids with piecewise continuous parameters in a uniform gravity field. It is demonstrated that the shear acoustic-gravity waves also can be supported by moving fluids as well as quiescent, viscous fluids with and without thermal conductivity. Excitation of a shear-wave normal mode by a point source and the normal mode distortion in realistic environmental models are considered. The shear acoustic-gravity waves are likely to play a significant role in coupling wave processes in the ocean and atmosphere. PMID:24606251

  5. Exoplanet Caught on the Move

    Science.gov (United States)

    2010-06-01

    For the first time, astronomers have been able to directly follow the motion of an exoplanet as it moves from one side of its host star to the other. The planet has the smallest orbit so far of all directly imaged exoplanets, lying almost as close to its parent star as Saturn is to the Sun. Scientists believe that it may have formed in a similar way to the giant planets in the Solar System. Because the star is so young, this discovery proves that gas giant planets can form within discs in only a few million years, a short time in cosmic terms. Only 12 million years old, or less than three-thousandths of the age of the Sun, Beta Pictoris is 75% more massive than our parent star. It is located about 60 light-years away towards the constellation of Pictor (the Painter) and is one of the best-known examples of a star surrounded by a dusty debris disc [1]. Earlier observations showed a warp of the disc, a secondary inclined disc and comets falling onto the star. "Those were indirect, but tell-tale signs that strongly suggested the presence of a massive planet, and our new observations now definitively prove this," says team leader Anne-Marie Lagrange. "Because the star is so young, our results prove that giant planets can form in discs in time-spans as short as a few million years." Recent observations have shown that discs around young stars disperse within a few million years, and that giant planet formation must occur faster than previously thought. Beta Pictoris is now clear proof that this is indeed possible. The team used the NAOS-CONICA instrument (or NACO [2]), mounted on one of the 8.2-metre Unit Telescopes of ESO's Very Large Telescope (VLT), to study the immediate surroundings of Beta Pictoris in 2003, 2008 and 2009. In 2003 a faint source inside the disc was seen (eso0842), but it was not possible to exclude the remote possibility that it was a background star. In new images taken in 2008 and spring 2009 the source had disappeared! The most recent

  6. Biology Notes.

    Science.gov (United States)

    School Science Review, 1982

    1982-01-01

    Presents procedures, exercises, demonstrations, and information on a variety of biology topics including labeling systems, biological indicators of stream pollution, growth of lichens, reproductive capacity of bulbous buttercups, a straw balance to measure transpiration, interaction of fungi, osmosis, and nitrogen fixation and crop production. (DC)

  7. Application of a liquid chromatographic procedure for the analysis of penicillin antibiotics in biological fluids and pharmaceutical formulations using sodium dodecyl sulphate/propanol mobile phases and direct injection.

    Science.gov (United States)

    Rambla-Alegre, Maria; Martí-Centelles, Rosa; Esteve-Romero, Josep; Carda-Broch, Samuel

    2011-07-29

    A direct injection liquid chromatography procedure was developed for the simultaneous determination of four penicillin antibiotics (amoxicillin, ampicillin, cloxacillin and dicloxacillin) in pharmaceutical formulations and physiological fluids (urine) using hybrid micellar mobile phases. These antimicrobials are used to treat gastrointestinal and systemic infections. The four penicillins were analysed using a Zorbax C18 reversed-phase column and detected at 210 nm. These antibiotics were separated by an interpretive optimisation procedure based on the accurate description of the retention and shape of the chromatographic peaks. Antibiotics were eluted in less than 16 min with no interference by the urine protein band or endogenous compounds using the mobile phase 0.11 M sodium dodecyl sulphate-6% propanol-0.01 M NaH(2)PO(4) buffered at pH 3. The method was validated according to the Food and Drug Administration guideline, including analytical parameters such as linearity (R(2)>0.993), intra- and inter-day precisions (RSD, %: 0.1-4.4 and 1.2-5.9, respectively), and robustness for the four compounds. This method is sensitive enough for the routine analysis of penicillins at therapeutic urine levels, with limits of detection in the 1.5-15 ng mL(-1) range and limits of quantification of 50 ng mL(-1). Recoveries in a micellar medium and a spiked urine matrix were in the 92.4-108.2% and 96-110% ranges, respectively. Finally, the method was successfully applied to determine these antibiotics in urine samples and pharmaceutical formulations. PMID:21190691

  8. Development of a Parallel Overset Grid Framework for Moving Body Simulations in OpenFOAM

    OpenAIRE

    Dominic Chandar

    2015-01-01

    OpenFOAM is an industry-standard Open-Source fluid dynamics code that is used to solve the Navier-Stokes equations for a variety of flow situations. It is currently being used extensively by researchers to study a plethora of physical problems ranging from fundamental fluid dynamics to complex multiphase flows. When it comes to modeling the flow surrounding moving bodies that involve large displacements such as that of ocean risers, sinking of a ship, or the free-flight of an insect, it is cu...

  9. Observations of spontaneous oscillations in simple two-fluid networks

    CERN Document Server

    Storey, Brian D; Karst, Nathaniel J; Geddes, John B

    2014-01-01

    Nonlinear phenomena including multiple equilibria and spontaneous oscillations are common in fluid networks containing either multiple phases or constituent flows. In many systems, such behavior might be attributed to the complicated geometry of the network, the complex rheology of the constituent fluids, or, in the case of microvascular blood flow, biological control. In this paper we investigate a simple fluid network containing two miscible Newtonian fluids of differing viscosities. We demonstrate experimentally that such networks can be unstable and that experiments agree with theoretical predictions of the existence of such oscillations.

  10. The action principle for generalized fluid motion including gyroviscosity

    Science.gov (United States)

    Lingam, M.; Morrison, P. J.

    2014-11-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  11. The action principle for generalized fluid motion including gyroviscosity

    CERN Document Server

    Lingam, M

    2014-01-01

    A general set of fluid equations that allow for energy-conserving momentum transport by gyroscopic motion of fluid elements is obtained. The equations are produced by a class of action principles that yield a large subset of the known fluid and magnetofluid models, including gyroviscosity. Analysis of the action principle yields broad, model-independent results regarding the conservation laws of energy and linear and angular momenta. The formalism is illustrated by studying fluid models with intrinsic angular momentum that may appear in the contexts of condensed matter, biological, and other areas of physics.

  12. HEAT TRANSFER FLUIDS

    OpenAIRE

    Lenert, Andrej; Nam, Youngsuk; Wang, Evelyn N.

    2012-01-01

    The choice of heat transfer fluids has significant effects on the performance, cost, and reliability of solar thermal systems. In this chapter, we evaluate existing heat transfer fluids such as oils and molten salts based on a new figure of merit capturing the combined effects of thermal storage capacity, convective heat transfer characteristics, and hydraulic performance of the fluids. Thermal stability, freezing point, and safety issues are also discussed. Through a comparative analysis, we...

  13. Metalworking and machining fluids

    Science.gov (United States)

    Erdemir, Ali; Sykora, Frank; Dorbeck, Mark

    2010-10-12

    Improved boron-based metal working and machining fluids. Boric acid and boron-based additives that, when mixed with certain carrier fluids, such as water, cellulose and/or cellulose derivatives, polyhydric alcohol, polyalkylene glycol, polyvinyl alcohol, starch, dextrin, in solid and/or solvated forms result in improved metalworking and machining of metallic work pieces. Fluids manufactured with boric acid or boron-based additives effectively reduce friction, prevent galling and severe wear problems on cutting and forming tools.

  14. Being Moved: Linguistic Representation and Conceptual Structure

    Directory of Open Access Journals (Sweden)

    Milena eKuehnast

    2014-11-01

    Full Text Available This study explored the organisation of the semantic field and the conceptual structure of moving experiences by investigating German-language expressions referring to the emotional state of being moved. We used present and past participles of eight psychological verbs as primes in a free word-association task, as these grammatical forms place their conceptual focus on the eliciting situation and on the felt emotional state, respectively. By applying a taxonomy of basic knowledge types and computing the Cognitive Salience Index, we identified joy and sadness as key emotional ingredients of being moved, and significant life events and art experiences as main elicitors of this emotional state. Metric multidimensional scaling analyses of the semantic field revealed that the core terms designate a cluster of emotional states characterised by low degrees of arousal and slightly positive valence, the latter due to a nearly balanced representation of positive and negative elements in the conceptual structure of being moved.

  15. Moving objects management models, techniques and applications

    CERN Document Server

    Meng, Xiaofeng; Xu, Jiajie

    2014-01-01

    This book describes the topics of moving objects modeling and location tracking, indexing and querying, clustering, location uncertainty, traffic aware navigation and privacy issues as well as the application to intelligent transportation systems.

  16. Sad Music Moves Those Who Are Empathetic

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_160987.html Sad Music Moves Those Who Are Empathetic They become engrossed ... 15, 2016 (HealthDay News) -- Many people find sad music relaxing but to those who are very empathetic, ...

  17. Reciprocal Effects between Fluid and Crystallized Intelligence and Their Dependence on Parents' Socioeconomic Status and Education

    Science.gov (United States)

    Rindermann, Heiner; Flores-Mendoza, Carmen; Mansur-Alves, Marcela

    2010-01-01

    The investment theory of Cattell supposes an influence of fluid on crystallized intelligence. The development of fluid intelligence largely depends on biological factors, of crystallized intelligence on fluid intelligence and environmental stimulation. To test this theory two contrasting samples representing a broad ability range were chosen, a…

  18. Theoretical Fluid Dynamics

    CERN Document Server

    Shivamoggi, Bhimsen K

    1998-01-01

    "Although there are many texts and monographs on fluid dynamics, I do not know of any which is as comprehensive as the present book. It surveys nearly the entire field of classical fluid dynamics in an advanced, compact, and clear manner, and discusses the various conceptual and analytical models of fluid flow." - Foundations of Physics on the first edition. Theoretical Fluid Dynamics functions equally well as a graduate-level text and a professional reference. Steering a middle course between the empiricism of engineering and the abstractions of pure mathematics, the author focuses

  19. Spiral fluid separator

    Science.gov (United States)

    Robertson, Glen A. (Inventor)

    1993-01-01

    A fluid separator for separating particulate matter such as contaminates is provided which includes a series of spiral tubes of progressively decreasing cross sectional area connected in series. Each tube has an outlet on the outer curvature of the spiral. As fluid spirals down a tube, centrifugal force acts to force the heavier particulate matter to the outer wall of the tube, where it exits through the outlet. The remaining, and now cleaner, fluid reaches the next tube, which is smaller in cross sectional area, where the process is repeated. The fluid which comes out the final tube is diminished of particulate matter.

  20. Electrorheological fluids and methods

    Energy Technology Data Exchange (ETDEWEB)

    Green, Peter F.; McIntyre, Ernest C.

    2015-06-02

    Electrorheological fluids and methods include changes in liquid-like materials that can flow like milk and subsequently form solid-like structures under applied electric fields; e.g., about 1 kV/mm. Such fluids can be used in various ways as smart suspensions, including uses in automotive, defense, and civil engineering applications. Electrorheological fluids and methods include one or more polar molecule substituted polyhedral silsesquioxanes (e.g., sulfonated polyhedral silsesquioxanes) and one or more oils (e.g., silicone oil), where the fluid can be subjected to an electric field.