WorldWideScience

Sample records for biology mission module

  1. Biological modulation of tectonics

    Science.gov (United States)

    Sleep, N. H.; Bird, D. K.

    2008-12-01

    Photosynthesis has had geologic consequences over the Earth's history. In addition to modifying Earth's atmosphere and ocean chemistry, it has also modulated tectonic processes through enhanced weathering and modification of the nature and composition of sedimentary rocks within fold mountain belts and convergent margins. Molecular biological studies indicate that bacterial photosynthesis evolved just once and that most bacterial clades descend from this photosynthetic common ancestor. Iron-based photosynthesis (ideally 4FeO + CO2 + H2O = 2Fe2O3 + CH2O) was the most bountiful anoxygenic niche on land. The back reaction provided energy to heterotrophic microbes and returned FeO to the photosynthetic microbes. Bacterial land colonists evolved into ecosystems that effectively weathered FeO-bearing minerals and volcanic glass. Clays, sands, and dissolved cations from the weathering process entered the ocean and formed our familiar classes sedimentary rocks: shales, sandstones, and carbonates. Marine photosynthesis caused organic carbon to accumulate in black shales. In contrast, non-photosynthetic ecosystems do not cause organic carbon to accumulate in shale. These evolutionary events occurred before 3.8 Ga as black shales are among the oldest rock types (Rosing and Frei, Earth Planet. Sci. Lett. 217, 237-244, 2004). Thick sedimentary sequences deformed into fold mountain belts. They remelted at depth to form granitic rocks (Rosing et al., Palaeoclimatol. Palaeoecol. 232, 99-11, 2006). Regions of outcropping low-FeO rocks including granites, quartzites, and some shales were a direct result. This dearth of FeO favored the evolution of oxic photosynthesis of cyanobacteria from photosynthetic soil bacteria. Black shales have an additional modulation effect on tectonics as they concentrate radioactive elements, particularly uranium (e.g. so that the surface heat flow varies by a factor of ca. 2). Thick sequences of black shales at continental rises of passive margins are

  2. Manned Mission Space Exploration Utilizing a Flexible Universal Module

    Science.gov (United States)

    Humphries, P.; Barez, F.; Gowda, A.

    2018-02-01

    The proposed ASMS, Inc. "Flexible Universal Module" is in support of NASA's Deep Space Gateway project. The Flexible Universal Module provides a possible habitation or manufacturing environment in support of Manned Mission for Space Exploration.

  3. AstroBiology Explorer Mission Concepts (ABE/ASPIRE)

    Science.gov (United States)

    Sandford, Scott; Ennico, Kimberly A.

    2006-01-01

    The AstroBiology Explorer (ABE) and the Astrobiology Space InfraRed Explorer (ASPIRE) Mission Concepts are two missions designed to address the questions (1) Where do we come from? and (2) Are we alone? as outlined in NASA s Origins Program using infrared spectroscopy to explore the identity, abundance, and distribution of molecules of astrobiological importance throughout the Universe. The ABE mission s observational program is focused on six tasks to: (1) Investigate the evolution of ice and organics in dense clouds and star formation regions, and the young stellar/planetary systems that form in them; (2) Measure the evolution of complex organic molecules in stellar outflows; (3) Study the organic composition of a wide variety of solar system objects including asteroids, comets, and the planets and their satellites; (4) Identify organic compounds in the diffuse interstellar medium and determine their distribution , abundance, and change with environment; (5) Detect and identify organic compounds in other galaxies and determine their dependence on galactic type; and (6) Measure deuterium enrichments in interstellar organics and use them as tracers of chemical processes. The ASPIRE mission s observational program expands upon ABE's core mission and adds tasks that (7) Address the role of silicates in interstellar organic chemistry; and (8) Use different resolution spectra to assess the relative roles and abundances of gas- and solid-state materials. ABE (ASPIRE) achieves these goals using a highly sensitive, cryogenically-cooled telescope in an Earth drift-away heliocentric orbit, armed with a suite of infrared spectrometers that cover the 2.5-20(40) micron spectral region at moderate spectral resolution (R>2000). ASPIRE's spectrometer complement also includes a high-resolution (R>25,000) module over the 4-8 micron spectral region. Both missions target lists are chosen to observe a statistically significant sample of a large number of objects of varied types in

  4. Space Radiation and Manned Mission: Interface Between Physics and Biology

    Science.gov (United States)

    Hei, Tom

    2012-07-01

    The natural radiation environment in space consists of a mixed field of high energy protons, heavy ions, electrons and alpha particles. Interplanetary travel to the International Space Station and any planned establishment of satellite colonies on other solar system implies radiation exposure to the crew and is a major concern to space agencies. With shielding, the radiation exposure level in manned space missions is likely to be chronic, low dose irradiation. Traditionally, our knowledge of biological effects of cosmic radiation in deep space is almost exclusively derived from ground-based accelerator experiments with heavy ions in animal or in vitro models. Radiobiological effects of low doses of ionizing radiation are subjected to modulations by various parameters including bystander effects, adaptive response, genomic instability and genetic susceptibility of the exposed individuals. Radiation dosimetry and modeling will provide conformational input in areas where data are difficult to acquire experimentally. However, modeling is only as good as the quality of input data. This lecture will discuss the interdependent nature of physics and biology in assessing the radiobiological response to space radiation.

  5. Dense module enumeration in biological networks

    International Nuclear Information System (INIS)

    Tsuda, Koji; Georgii, Elisabeth

    2009-01-01

    Analysis of large networks is a central topic in various research fields including biology, sociology, and web mining. Detection of dense modules (a.k.a. clusters) is an important step to analyze the networks. Though numerous methods have been proposed to this aim, they often lack mathematical rigorousness. Namely, there is no guarantee that all dense modules are detected. Here, we present a novel reverse-search-based method for enumerating all dense modules. Furthermore, constraints from additional data sources such as gene expression profiles or customer profiles can be integrated, so that we can systematically detect dense modules with interesting profiles. We report successful applications in human protein interaction network analyses.

  6. Abort Region Determinator (ARD) module feasibility report. Mission planning, mission analysis and software formulation

    Science.gov (United States)

    Draeger, B. G.; Joyner, J. A.

    1976-01-01

    A detailed performance evaluation of the Abort Region Determinator (ARD) module design was provided in support of OFT-1 ascent and OFT-1 intact launch aborts. The evaluation method used compared ARD results against results obtained using the full-up Space Vehicle Dynamic Simulations program under the same conditions. Results were presented for each of the three major ARD math models: (1) the ascent numerical integrator; (2) the mass model, and (3) the second stage predictor as well as the total ARD module. These results demonstrate that the baselined ARD module meets all design objectives for mission control center orbital flight test launch/abort support.

  7. Biological implications of the Viking mission to Mars

    International Nuclear Information System (INIS)

    Mazur, P.; Barghoorn, E.S.; Jukes, T.H.; Margulis, L.

    1978-01-01

    A central purpose of Viking was to search for evidence that life exists on Mars or may have existed in the past. The missions carried three biology experiments the prime purpose of which was to seek for existing microbial life. They produced clear evidence of chemical reactivity in soil samples, but it is becoming increasingly clear that the chemical reactions were nonbiological in origin. The unexpected release of oxygen by soil moistened with water vapor in the Gas Exchange experiment together with the negative findings of the organic analysis experiment lead to the conclusion that the surface contains powerful oxidants. This conclusion is consistent with models of the atmosphere. The oxidants appear also to have been responsible for the decarboxylation of the organic nutrients that were introduced in the Label Release experiment. The major results of the GEX and LR experiments have been simulated at least qualitatively on Earth. The third, Pyrolytic Release, experiment obtained evidence for organic synthesis by soil samples. Although the mechanism of the synthesis is obscure, the thermal stability of the reaction makes a biological explanation most unlikely. Furthermore, the response of soil samples in all three experiments to the addition of water is not consistent with a biological interpretation. (Auth.)

  8. Physicochemical and biological technologies for future exploration missions

    Science.gov (United States)

    Belz, S.; Buchert, M.; Bretschneider, J.; Nathanson, E.; Fasoulas, S.

    2014-08-01

    Life Support Systems (LSS) are essential for human spaceflight. They are the key element for humans to survive, to live and to work in space. Ambitious goals of human space exploration in the next 40 years like a permanently crewed surface habitat on Moon or a manned mission to Mars require technologies which allow for a reduction of system and resupply mass. Enhancements of existing technologies, new technological developments and synergetic components integration help to close the oxygen, water and carbon loops. In order to design the most efficient LSS architecture for a given mission scenario, it is important to follow a dedicated design process: definition of requirements, selection of candidate technologies, development of possible LSS architectures and characterisation of LSS architectures by system drivers and evaluation of the LSS architectures. This paper focuses on the approach of a synergetic integration of Polymer Electrolyte Membrane Fuel Cells (PEFC) and microalgae cultivated in photobioreactors (PBR). LSS architectures and their benefits for selected mission scenarios are demonstrated. Experiments on critical processes and interfaces were conducted and result in engineering models for a PEFC and PBR system which fulfil the requirements of a synergetic integrative environment. The PEFC system (about 1 kW) can be operated with cabin air enriched by stored or biologically generated oxygen instead of pure oxygen. This offers further advantages with regard to thermal control as high oxygen concentrations effect a dense heat production. The PBR system consists of an illuminated cultivation chamber (about 5 l), a nutrients supply and harvesting and analytics units. Especially the chamber enables a microgravity adapted cultivation of microalgae. However, the peripheral units still have to be adapted in order to allow for a continuous and automated cultivation and harvesting. These automation processes will be tested and evaluated by means of a parabolic

  9. An integrative approach to inferring biologically meaningful gene modules

    Directory of Open Access Journals (Sweden)

    Wang Kai

    2011-07-01

    Full Text Available Abstract Background The ability to construct biologically meaningful gene networks and modules is critical for contemporary systems biology. Though recent studies have demonstrated the power of using gene modules to shed light on the functioning of complex biological systems, most modules in these networks have shown little association with meaningful biological function. We have devised a method which directly incorporates gene ontology (GO annotation in construction of gene modules in order to gain better functional association. Results We have devised a method, Semantic Similarity-Integrated approach for Modularization (SSIM that integrates various gene-gene pairwise similarity values, including information obtained from gene expression, protein-protein interactions and GO annotations, in the construction of modules using affinity propagation clustering. We demonstrated the performance of the proposed method using data from two complex biological responses: 1. the osmotic shock response in Saccharomyces cerevisiae, and 2. the prion-induced pathogenic mouse model. In comparison with two previously reported algorithms, modules identified by SSIM showed significantly stronger association with biological functions. Conclusions The incorporation of semantic similarity based on GO annotation with gene expression and protein-protein interaction data can greatly enhance the functional relevance of inferred gene modules. In addition, the SSIM approach can also reveal the hierarchical structure of gene modules to gain a broader functional view of the biological system. Hence, the proposed method can facilitate comprehensive and in-depth analysis of high throughput experimental data at the gene network level.

  10. Planetary Atmosphere Probe Descent Modules for Gas and Ice Giant Missions

    Science.gov (United States)

    Amato, M. J.; Jones, A. L.; Robinson, D. W.; Jabola, A.

    2014-06-01

    Probe missions enabling in-situ measurements at gas and ice giants enable critical and needed science measurements. And lend themselves to probe decent modules using achievable approaches and technology. We discuss work on updated and new designs.

  11. A Project-Based Biologically-Inspired Robotics Module

    Science.gov (United States)

    Crowder, R. M.; Zauner, K.-P.

    2013-01-01

    The design of any robotic system requires input from engineers from a variety of technical fields. This paper describes a project-based module, "Biologically-Inspired Robotics," that is offered to Electronics and Computer Science students at the University of Southampton, U.K. The overall objective of the module is for student groups to…

  12. A Synthetic Biology Tool Kit for Manned Missions Outside Low Earth Orbit

    Data.gov (United States)

    National Aeronautics and Space Administration — Our goal is to make human missions outside low earth orbit safer and better able to handle the unexpected through the use of synthetic biology as an enabling...

  13. Tactical mobile robotic search and rescue mission modules

    Science.gov (United States)

    McAndrew, David R.; Mangolds, Arnis; Deguire, Daniel R.

    2000-07-01

    Foster-Miller, under the sponsorship of LTC John Blitch's DARPA TMR program, has developed a number of prototype payloads that can be fit onto small robotic platforms for the purpose of performing various search and rescue functions. Presently they have been designed for the Lemmings-type vehicle but the intent in to construct them so that they are plug and play modules for a larger variety of systems. The function modules include: modified image intensifiers and thermal cameras for dark terrain search; two-way voice communications; fingerprint identification; door breaching for operation in hazardous environments; water, material and air sampling and monitoring kits; deployable combat casualty rescue nets; and rescue line launchers with fire control. The vehicle is amphibious to 90-ft and has been fitted with various underwater sensors for search and recovery operations. The vehicle can be fitted with a 14, 18 or a 40-in fold-up mast for out of reach operations. This paper will discuss the functionality of the subsystems and how they relate to robotic platforms.

  14. The Single Habitat Module Concept for Exploration - Mission Planning and Mass Estimates

    Science.gov (United States)

    Chambliss, Joe; Studak, J. W.

    2013-01-01

    The Single Habitat Module (SHM) concept approach to the infrastructure and conduct of exploration missions combines many new promising technologies with a central concept of mission architectures that use a single habitat module for all phases of an exploration mission. Integrating mission elements near Earth and fully fueling them prior to departure of the vicinity of Earth provides the capability of using the single habitat both in transit to/from an exploration destination and while exploring the destination. The concept employs the capability to return the habitat and interplanetary propulsion system to Earth vicinity so that those elements can be reused on subsequent exploration missions. This paper provides an overview of the SHM concept and the advantages it provides. The paper also provides a summary of calculations of the mass of the Habitat Propulsion System (HPS) needed to get the habitat from low-Mars orbit (LMO) to the surface and back to LMO, and an overview of trajectory and mission mass assessments related to use of a high specific impulse space-based propulsion system. Those calculations led to the conclusion that the SHM concept results in low total mass required and streamlines mission operations to explore Mars (or other exploration destinations).

  15. The AstroBiology Explorer (ABE) Mission Concept

    Science.gov (United States)

    Sandford, Scott A.

    2004-01-01

    Infrared spectroscopy in the 2.5-16 micron range is a principle means by which organic compounds can be detected and identified in space via their vibrational transitions. Ground-based, airborne, and spaceborne IR spectral studies have already demonstrated that a significant fraction of the carbon in the interstellar medium (ISM) resides in the form of complex organic molecular species. Unfortunately, neither the distribution of these materials nor their genetic and evolutionary relationships with each other or their environments are well understood. The Astrobiology Explorer (ABE) is a MIDEX mission concept currently under study by a team of partners: NASA's Ames Research Center, Ball Aerospace and Technologies Corporation, and the Jet Propulsion Laboratory. ABE will conduct IR spectroscopic observations to address outstanding important problems in astrobiology, astrochemistry, and astrophysics. The core observational program would make fundamental scientific progress in understanding (1) The evolution of ices and organic matter in dense molecular clouds and young forming stellar systems, (2) The chemical evolution of organic molecules in the ISM as they transition from AGB outflows to planetary nebulae to the general diffuse ISM to HII regions and dense clouds, (3) The distribution of organics in the diffuse ISM, (4) The nature of organics in the Solar System (in comets, asteroids, satellites), and (5) The nature and distribution of organics in local galaxies. The technical considerations of achieving these science objectives in a MIDEX-sized mission will be presented.

  16. Mission-profile-based stress analysis of bond-wires in SiC power modules

    DEFF Research Database (Denmark)

    Bahman, Amir Sajjad; Iannuzzo, Francesco; Blaabjerg, Frede

    2016-01-01

    This paper proposes a novel mission-profile-based reliability analysis approach for stress on bond wires in Silicon Carbide (SiC) MOSFET power modules using statistics and thermo-mechanical FEM analysis. In the proposed approach, both the operational and environmental thermal stresses are taken...... and the mechanical stress on bond wires is consequently extracted by finite-element simulations. In the final step, the considered mission profile is translated in a stress sequence to be used for Rainflow counting calculation and lifetime estimation....

  17. Development and Calibration of the ART-XC Mirror Modules for the Spectrum Rontgen Gamma Mission

    Science.gov (United States)

    Ramsey, B.; Gubarev, M.; Elsner, R.; Kolodziejczak, J.; Odell, S.; Swartz, D.; Pavlinsky, M.; Tkachenko, A.; Lapshov, I.

    2013-01-01

    The Spectrum-Röntgen-Gamma (SRG) mission is a Russian-lead X-ray astrophysical observatory that carries two co-aligned X-ray telescope systems. The primary instrument is the German-led extended ROentgen Survey with an Imaging Telescope Array (eROSITA), a 7-module X-ray telescope system that covers the energy range from 0.2-12 keV. The complementary instrument is the Astronomical Roentgen Telescope -- X-ray Concentrator (ART-XC or ART), a 7-module Xray telescope system that provides higher energy coverage, up to 30 keV.

  18. STS-47 Mission Specialist (MS) Jemison conducts AFTE in SLJ module on OV-105

    Science.gov (United States)

    1992-01-01

    STS-47 Mission Specialist (MS) Mae C. Jemison, wearing autogenic feedback training system 2 suit, conducts the Autogenic Feedback Training Experiment (AFTE) in Spacelab Japan (SLJ) science module aboard Endeavour, Orbiter Vehicle (OV) 105. AFTE's objective is to teach astronauts to use biofeedback rather than drugs to combat nausea and other effects of space motion sickness. Jemison's physical responses are monitored by sensors attached to the suit.

  19. Mathematical biology modules based on modern molecular biology and modern discrete mathematics.

    Science.gov (United States)

    Robeva, Raina; Davies, Robin; Hodge, Terrell; Enyedi, Alexander

    2010-01-01

    We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network.

  20. Mathematical Biology Modules Based on Modern Molecular Biology and Modern Discrete Mathematics

    Science.gov (United States)

    Davies, Robin; Hodge, Terrell; Enyedi, Alexander

    2010-01-01

    We describe an ongoing collaborative curriculum materials development project between Sweet Briar College and Western Michigan University, with support from the National Science Foundation. We present a collection of modules under development that can be used in existing mathematics and biology courses, and we address a critical national need to introduce students to mathematical methods beyond the interface of biology with calculus. Based on ongoing research, and designed to use the project-based-learning approach, the modules highlight applications of modern discrete mathematics and algebraic statistics to pressing problems in molecular biology. For the majority of projects, calculus is not a required prerequisite and, due to the modest amount of mathematical background needed for some of the modules, the materials can be used for an early introduction to mathematical modeling. At the same time, most modules are connected with topics in linear and abstract algebra, algebraic geometry, and probability, and they can be used as meaningful applied introductions into the relevant advanced-level mathematics courses. Open-source software is used to facilitate the relevant computations. As a detailed example, we outline a module that focuses on Boolean models of the lac operon network. PMID:20810955

  1. On Beyond Star Trek, the Role of Synthetic Biology in Nasa's Missions

    Science.gov (United States)

    Rothschild, Lynn J.

    2016-01-01

    The time has come to for NASA to exploit the nascent field of synthetic biology in pursuit of its mission, including aeronautics, earth science, astrobiology and notably, human exploration. Conversely, NASA advances the fundamental technology of synthetic biology as no one else can because of its unique expertise in the origin of life and life in extreme environments, including the potential for alternate life forms. This enables unique, creative "game changing" advances. NASA's requirement for minimizing upmass in flight will also drive the field toward miniaturization and automation. These drivers will greatly increase the utility of synthetic biology solutions for military, health in remote areas and commercial purposes. To this end, we have begun a program at NASA to explore the use of synthetic biology in NASA's missions, particularly space exploration. As part of this program, we began hosting an iGEM team of undergraduates drawn from Brown and Stanford Universities to conduct synthetic biology research at NASA Ames Research Center. The 2011 team (http://2011.igem.org/Team:Brown-Stanford) produced an award-winning project on using synthetic biology as a basis for a human Mars settlement and the 2012 team has expanded the use of synthetic biology to estimate the potential for life in the clouds of other planets (http://2012.igem.org/Team:Stanford-Brown; http://www.calacademy.org/sciencetoday/igem-competition/). More recent projects from the Stanford-Brown team have expanded our ideas of how synthetic biology can aid NASA's missions from "Synthetic BioCommunication" (http://2013.igem.org/Team:Stanford-Brown) to a "Biodegradable UAS (drone)" in collaboration with Spelman College (http://2014.igem.org/Team:StanfordBrownSpelman#SBS%20iGEM) and most recently, "Self-Folding Origami" (http://2015.igem.org/Team:Stanford-Brown), the winner of the 2015 award for Manufacturing.

  2. Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms.

    Science.gov (United States)

    Wei, Min; Li, Song; Le, Weidong

    2017-10-25

    Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. The chemical and physical properties of surrounding microenvironment contribute to the growth and differentiation of stem cells and consequently play crucial roles in the regulation of stem cells' fate. Nanomaterials hold great promise in biological and biomedical fields owing to their unique properties, such as controllable particle size, facile synthesis, large surface-to-volume ratio, tunable surface chemistry, and biocompatibility. Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. In present review, we summarize recent progress in the regulating potential of various nanomaterials on stem cell differentiation and discuss the possible cell uptake, biological interaction and underlying mechanisms.

  3. Evaluating the feasibility of biological waste processing for long term space missions

    Science.gov (United States)

    Garland, J. L.; Alazraki, M. P.; Atkinson, C. F.; Finger, B. W.; Sager, J. C. (Principal Investigator)

    1998-01-01

    Recycling waste products during orbital (e.g., International Space Station) and planetary missions (e.g., lunar base, Mars transit mission, Martian base) will reduce storage and resupply costs. Wastes streams on the space station will include human hygiene water, urine, faeces, and trash. Longer term missions will contain human waste and inedible plant material from plant growth systems used for atmospheric regeneration, food production, and water recycling. The feasibility of biological and physical-chemical waste recycling is being investigated as part of National Aeronautics and Space Administration's (NASA) Advanced Life Support (ALS) Program. In-vessel composting has lower manpower requirements, lower water and volume requirements, and greater potential for sanitization of human waste compared to alternative bioreactor designs such as continuously stirred tank reactors (CSTR). Residual solids from the process (i.e. compost) could be used a biological air filter, a plant nutrient source, and a carbon sink. Potential in-vessel composting designs for both near- and long-term space missions are presented and discussed with respect to the unique aspects of space-based systems.

  4. In Situ Biological Contamination Studies of the Moon: Implications for Planetary Protection and Life Detection Missions

    Science.gov (United States)

    Glavin, Daniel P.; Dworkin, Jason P.; Lupisella, Mark; Williams, David R.; Kminek, Gerhard; Rummel, John D.

    2010-01-01

    NASA and ESA have outlined visions for solar system exploration that will include a series of lunar robotic precursor missions to prepare for, and support a human return to the Moan, and future human exploration of Mars and other destinations, including possibly asteroids. One of the guiding principles for exploration is to pursue compelling scientific questions about the origin and evolution of life. The search for life on objects such as Mars will require careful operations, and that all systems be sufficiently cleaned and sterilized prior to launch to ensure that the scientific integrity of extraterrestrial samples is not jeopardized by terrestrial organic contamination. Under the Committee on Space Research's (COSPAR's) current planetary protection policy for the Moon, no sterilization procedures are required for outbound lunar spacecraft, nor is there a different planetary protection category for human missions, although preliminary C SPAR policy guidelines for human missions to Mars have been developed. Future in situ investigations of a variety of locations on the Moon by highly sensitive instruments designed to search for biologically derived organic compounds would help assess the contamination of the Moon by lunar spacecraft. These studies could also provide valuable "ground truth" data for Mars sample return missions and help define planetary protection requirements for future Mars bound spacecraft carrying life detection experiments. In addition, studies of the impact of terrestrial contamination of the lunar surface by the Apollo astronauts could provide valuable data to help refine future: Mars surface exploration plans for a human mission to Mars.

  5. Bacterial microcompartments as metabolic modules for plant synthetic biology.

    Science.gov (United States)

    Gonzalez-Esquer, C Raul; Newnham, Sarah E; Kerfeld, Cheryl A

    2016-07-01

    Bacterial microcompartments (BMCs) are megadalton-sized protein assemblies that enclose segments of metabolic pathways within cells. They increase the catalytic efficiency of the encapsulated enzymes while sequestering volatile or toxic intermediates from the bulk cytosol. The first BMCs discovered were the carboxysomes of cyanobacteria. Carboxysomes compartmentalize the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) with carbonic anhydrase. They enhance the carboxylase activity of RuBisCO by increasing the local concentration of CO2 in the vicinity of the enzyme's active site. As a metabolic module for carbon fixation, carboxysomes could be transferred to eukaryotic organisms (e.g. plants) to increase photosynthetic efficiency. Within the scope of synthetic biology, carboxysomes and other BMCs hold even greater potential when considered a source of building blocks for the development of nanoreactors or three-dimensional scaffolds to increase the efficiency of either native or heterologously expressed enzymes. The carboxysome serves as an ideal model system for testing approaches to engineering BMCs because their expression in cyanobacteria provides a sensitive screen for form (appearance of polyhedral bodies) and function (ability to grow on air). We recount recent progress in the re-engineering of the carboxysome shell and core to offer a conceptual framework for the development of BMC-based architectures for applications in plant synthetic biology. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  6. A Biologically-Based Alternative Water Processor for Long Duration Space Missions

    Science.gov (United States)

    Barta, Daniel J.; Pickering, Karen D.; Meyer, Caitlin; Pensinger, Stuart; Vega, Leticia; Flynn, Michael; Jackson, Andrew; Wheeler, Raymond

    2015-01-01

    A wastewater recovery system has been developed that combines novel biological and physicochemical components for recycling wastewater on long duration space missions. Functionally, this Alternative Water Processor (AWP) would replace the Urine Processing Assembly on the International Space Station and reduce or eliminate the need for the multifiltration beds of the Water Processing Assembly (WPA). At its center are two unique game changing technologies: 1) a biological water processor (BWP) to mineralize organic forms of carbon and nitrogen and 2) an advanced membrane processor (Forward Osmosis Secondary Treatment) for removal of solids and inorganic ions. The AWP is designed for recycling larger quantities of wastewater from multiple sources expected during future exploration missions, including urine, hygiene (hand wash, shower, oral and shave) and laundry. The BWP utilizes a single-stage membrane-aerated biological reactor for simultaneous nitrification and denitrification. The Forward Osmosis Secondary Treatment (FOST) system uses a combination of forward osmosis (FO) and reverse osmosis (RO), is resistant to biofouling and can easily tolerate wastewaters high in non-volatile organics and solids associated with shower and/or hand washing. The BWP was operated continuously for over 300 days. After startup, the mature biological system averaged 85% organic carbon removal and 44% nitrogen removal, close to maximum based on available carbon. The FOST has averaged 93% water recovery, with a maximum of 98%. If the wastewater is slighty acidified, ammonia rejection is optimal. This paper will provide a description of the technology and summarize results from ground-based testing using real wastewater.

  7. Understanding the Role of Biology in the Global Environment: NASA'S Mission to Planet Earth

    Science.gov (United States)

    Townsend, William F.

    1996-01-01

    NASA has long used the unique perspective of space as a means of expanding our understanding of how the Earth's environment functions. In particular, the linkages between land, air, water, and life-the elements of the Earth system-are a focus for NASA's Mission to Planet Earth. This approach, called Earth system science, blends together fields like meteorology, biology, oceanography, and atmospheric science. Mission to Planet Earth uses observations from satellites, aircraft, balloons, and ground researchers as the basis for analysis of the elements of the Earth system, the interactions between those elements, and possible changes over the coming years and decades. This information is helping scientists improve our understanding of how natural processes affect us and how we might be affecting them. Such studies will yield improved weather forecasts, tools for managing agriculture and forests, information for fishermen and local planners, and, eventually, an enhanced ability to predict how the climate will change in the future. NASA has designed Mission to Planet Earth to focus on five primary themes: Land Cover and Land Use Change; Seasonal to Interannual Climate Prediction; Natural Hazards; Long-Term Climate Variability; and Atmosphere Ozone.

  8. Mining Functional Modules in Heterogeneous Biological Networks Using Multiplex PageRank Approach.

    Science.gov (United States)

    Li, Jun; Zhao, Patrick X

    2016-01-01

    Identification of functional modules/sub-networks in large-scale biological networks is one of the important research challenges in current bioinformatics and systems biology. Approaches have been developed to identify functional modules in single-class biological networks; however, methods for systematically and interactively mining multiple classes of heterogeneous biological networks are lacking. In this paper, we present a novel algorithm (called mPageRank) that utilizes the Multiplex PageRank approach to mine functional modules from two classes of biological networks. We demonstrate the capabilities of our approach by successfully mining functional biological modules through integrating expression-based gene-gene association networks and protein-protein interaction networks. We first compared the performance of our method with that of other methods using simulated data. We then applied our method to identify the cell division cycle related functional module and plant signaling defense-related functional module in the model plant Arabidopsis thaliana. Our results demonstrated that the mPageRank method is effective for mining sub-networks in both expression-based gene-gene association networks and protein-protein interaction networks, and has the potential to be adapted for the discovery of functional modules/sub-networks in other heterogeneous biological networks. The mPageRank executable program, source code, the datasets and results of the presented two case studies are publicly and freely available at http://plantgrn.noble.org/MPageRank/.

  9. Biological Production of Methane from Lunar Mission Solid Waste: An Initial Feasibility Assessment

    Science.gov (United States)

    Strayer, Richard; Garland, Jay; Janine, Captain

    A preliminary assessment was made of the potential for biological production of methane from solid waste generated during an early planetary base mission to the moon. This analysis includes: 1) estimation of the amount of biodegradable solid waste generated, 2) background on the potential biodegradability of plastics given their significance in solid wastes, and 3) calculation of potential methane production from the estimate of biodegradable waste. The completed analysis will also include the feasibility of biological methane production costs associated with the biological processing of the solid waste. NASA workshops and Advanced Life Support documentation have estimated the projected amount of solid wastes generated for specific space missions. From one workshop, waste estimates were made for a 180 day transit mission to Mars. The amount of plastic packaging material was not specified, but our visual examination of trash returned from stocktickerSTS missions indicated a large percentage would be plastic film. This plastic, which is not biodegradable, would amount to 1.526 kgdw crew-1 d-1 or 6.10 kgdw d-1 for a crew of 4. Over a mission of 10 days this would amount to 61 kgdw of plastics and for an 180 day lunar surface habitation it would be nearly 1100 kgdw . Approx. 24 % of this waste estimate would be biodegradable (human fecal waste, food waste, and paper), but if plastic packaging was replaced with biodegradable plastic, then 91% would be biodegradable. Plastics are man-made long chain polymeric molecules, and can be divided into two main groups; thermoplastics and thermoset plastics. Thermoplastics comprise over 90% of total plastic use in the placecountry-regionUnited States and are derived from polymerization of olefins via breakage of the double bond and subsequent formation of additional carbon to carbon bonds. The resulting sole-carbon chain polymers are highly resistant to biodegradation and hydrolytic cleavage. Common thermoplastics include low

  10. Development of mirror modules for the ART-XC instrument aboard the Spectrum-Roentgen-Gamma mission

    Science.gov (United States)

    Gubarev, M.; Ramsey, B.; O'Dell, S. L.; Elsner, R.; Kilaru, K.; McCracken, J.; Pavlinsky, M.; Tkachenko, A.; Lapshov, I.; Atkins, C.; Zavlin, V.

    2013-09-01

    The Marshall Space Flight Center (MSFC) is developing x-ray mirror modules for the ART-XC instrument on board the Spectrum-Roentgen Gamma Mission. Four of those modules are being fabricated under a Reimbursable Agreement between NASA and the Russian Space Research Institute (IKI.) An additional three flight modules and one spare for the ART-XC Instrument are produced under a Cooperative Agreement between NASA and IKI. The instrument will consist of seven co-aligned x-ray mirror modules with seven corresponding CdTe focal plane detectors. Each module consists of 28 nested thin Ni/Co shells giving an effective area of 65 cm2 at 8 keV, response out to 30 keV, and an angular resolution of 45 arcsec or better HPD. Delivery of the first four modules is scheduled for November 2013, while the remaining three modules will be delivered to IKI in January 2014. We present a status of the ART x-ray module development at MSFC.

  11. Characterizing the detection module paving the ECLAIRs camera for the SVOM gamma-ray buts mission

    International Nuclear Information System (INIS)

    Nasser, Guillaume

    2015-01-01

    Gamma-ray bursts (GRBs) are short and very intense flashes of X-gamma-ray photons lasting from few milliseconds to hundreds of seconds appearing randomly over the sky. These cosmological events are thought to be due to the catastrophic formation of newly formed black holes following the collapse of some massive stars or after the coalescence of two compact objects and resulting in the launch of powerful ultra-relativistic jets orientated towards the Earth. The Sino-French mission SVOM (Space-based multi-band Variable Object Monitor) is dedicated to the study of these extreme and fascinating transient events and expected to be launched in 2020's. The satellite will implement a multi-wavelength science payload amongst which the core will be the large-field coded-mask camera ECLAIRs in charge of the detection and the localisation of GRBs in the 4-150 keV range. The ECLAIRs detection plane, DPIX, is made of 80x80 Schottky CdTe semi-conductor detectors and the front-end electronics. During my PhD, I mainly worked on the characterization of the scientific performance of the elementary detection modules called XRDPIX (i.e. a hybrid made of 8*4 detectors coupled with a low-noise ASIC) that will paved the DPIX. The main goal is then to derive the best suitable choice of the instrumental parameters in order to optimize the camera in-flight performance. In the manuscript, I discuss the methodology I used to explore the instrument parameter space. I describe the various testing protocols that I created and the different tests that I performed using several XRDPIX modules in a thermal-vacuum chamber and irradiated with radioactive sources. I discuss in detail the results and the various observables that I used to define the optimal in-flight operating zone of the detection plane. I also study the contribution of the different noise sources coming from the detectors and the electronic chain with a model I designed in order to control the quality of the hybridization process

  12. Prototype Biology-Based Radiation Risk Module Project

    Science.gov (United States)

    Terrier, Douglas; Clayton, Ronald G.; Patel, Zarana; Hu, Shaowen; Huff, Janice

    2015-01-01

    Biological effects of space radiation and risk mitigation are strategic knowledge gaps for the Evolvable Mars Campaign. The current epidemiology-based NASA Space Cancer Risk (NSCR) model contains large uncertainties (HAT #6.5a) due to lack of information on the radiobiology of galactic cosmic rays (GCR) and lack of human data. The use of experimental models that most accurately replicate the response of human tissues is critical for precision in risk projections. Our proposed study will compare DNA damage, histological, and cell kinetic parameters after irradiation in normal 2D human cells versus 3D tissue models, and it will use a multi-scale computational model (CHASTE) to investigate various biological processes that may contribute to carcinogenesis, including radiation-induced cellular signaling pathways. This cross-disciplinary work, with biological validation of an evolvable mathematical computational model, will help reduce uncertainties within NSCR and aid risk mitigation for radiation-induced carcinogenesis.

  13. Single-event drag modulated aerocapture at Venus for a small satellite science mission

    Data.gov (United States)

    National Aeronautics and Space Administration — Ames will perform a concept study in fall to formulate a baseline mission. ARC will then conduct trajectory analyses to define the entry environments. This will feed...

  14. Cultural and biological factors modulate spatial biases over development.

    Science.gov (United States)

    Girelli, Luisa; Marinelli, Chiara Valeria; Grossi, Giuseppe; Arduino, Lisa S

    2017-11-01

    Increasing evidence supports the contribution of both biological and cultural factors to visuospatial processing. The present study adds to the literature by exploring the interplay of perceptual and linguistic mechanisms in determining visuospatial asymmetries in adults (Experiment 1) and children (Experiment 2). In particular, pre-schoolers (3 and 5 year-olds), school-aged children (8 year-old), and adult participants were required to bisect different types of stimuli, that is, lines, words, and figure strings. In accordance with the literature, results yielded a leftward bias for lines and words and a rightward bias for figure strings, in adult participants. More critically, different biases were found for lines, words, and figure strings in children as a function of age, reflecting the impact of both cultural and biological factors on the processing of different visuospatial materials. Specifically, an adult-like pattern of results emerged only in the older group of children (8 year-old), but not in pre-schoolers. Results are discussed in terms of literacy, reading habits exposure, and biological maturation.

  15. Online interactive teaching modules enhance quantitative proficiency of introductory biology students.

    Science.gov (United States)

    Thompson, Katerina V; Nelson, Kären C; Marbach-Ad, Gili; Keller, Michael; Fagan, William F

    2010-01-01

    There is widespread agreement within the scientific and education communities that undergraduate biology curricula fall short in providing students with the quantitative and interdisciplinary problem-solving skills they need to obtain a deep understanding of biological phenomena and be prepared fully to contribute to future scientific inquiry. MathBench Biology Modules were designed to address these needs through a series of interactive, Web-based modules that can be used to supplement existing course content across the biological sciences curriculum. The effect of the modules was assessed in an introductory biology course at the University of Maryland. Over the course of the semester, students showed significant increases in quantitative skills that were independent of previous math course work. Students also showed increased comfort with solving quantitative problems, whether or not they ultimately arrived at the correct answer. A survey of spring 2009 graduates indicated that those who had experienced MathBench in their course work had a greater appreciation for the role of mathematics in modern biology than those who had not used MathBench. MathBench modules allow students from diverse educational backgrounds to hone their quantitative skills, preparing them for more complex mathematical approaches in upper-division courses.

  16. TeSeR – Technology for Self-Removal – First results of an H2020 Project to develop a Post-Mission-Disposal Module

    DEFF Research Database (Denmark)

    Voigt, p.; Vogt, C.; Schubert, R.

    2017-01-01

    The goal of TeSeR (Technology for Self-Removal) is to take the first step towards the development of a scalable, flexible, cost-efficient, but highly reliable Post-Mission-Disposal (PMD) module. This module is to be attached to the spacecraft (S/C) on ground and it shall ensure the PMD of the S...

  17. The polarization modulators based on liquid crystal variable retarders for the PHI and METIS instruments for the solar orbiter mission

    Science.gov (United States)

    Alvarez-Herrero, A.; García Parejo, P.; Laguna, H.; Villanueva, J.; Barandiarán, J.; Bastide, L.; Reina, M.; Royo, M.

    2017-11-01

    A technical development activity was carried out from 2009 to 2011 under ESA supervision to validate the Liquid Crystal Variable Retarders (LCVRs) as polarization modulators for the Solar Orbiter mission. After this, the technology achieved the Technology Readiness Level 5 (TRL5) corresponding to "Component Validation in Relevant Environment". Afterwards, additional tests and characterizations were performed in order to select the final specifications of the LCVRs cells to optimize their performances under the mission environmental conditions. The LCVRs will be used to measure the complete Stokes vector of the incoming light in PHI (The Polarimetric and Helioseismic Imager for Solar Orbiter) and the linear polarization in the case of METIS (Multi Element Telescope for Imaging and Spectroscopy). PHI is an imaging spectro-polarimeter that will acquire high resolution solar magnetograms. On the other hand, METIS is a solar coronagraph that will analyze the linear polarization for observations of the visible-light K-corona. The polarization modulators are described in this work including the optical, mechanical, thermal and electrical aspects. Both modulators will consist of two identical LCVRs with a relative azimuth orientation of 45° for PHI and parallel for the METIS modulator. In the first case, the configuration allows the analysis of the full Stockes vector with maximum polarimetric efficiencies. In the second setup, wide acceptance angles (stress produced by the mounts to the cells, but taking into account the vibration environment due to the launch loads that the device shall withstand. Additionally, the optical clear aperture has been maximized and the design avoids breaks due to thermo-elastic deformations produced during the thermal cycling. Finally, the electrical cables and connections have been designed to obtain a very compact, modular and robust device.

  18. PENGEMBANGAN MODUL EVOLUSI PRIMATA INDONESIA BERDASARKAN HASIL PENELITIAN BAGI MAHASISWA S1 PENDIDIKAN BIOLOGI

    Directory of Open Access Journals (Sweden)

    Suparno Putera Makkadafi

    2017-08-01

    Full Text Available The purpose of this research is to develop a module based on research for undergraduate students in Biology Education Mulawarman University. Result of development is a module from design phase and validate by subject expert, instructional media expert, and small group test. Validation result from subject expert is 84,38%, in valid enough category and result from instructional media expert is 94,16% in valid category. Small group test result is 82% in valid ebough category. Validation results in qualitative and quantitative data is used to revised module. Penelitian ini bertujuan untuk menghasilkan produk berupa modul berdasarkan hasil penelitian untuk mahasiswa S1 Pendidikan Biologi Universitas Mulawarman. Hasil pengembangan berupa draft modul hasil tahap desain kemudian divalidasi oleh ahli materi, ahli media pembelajaran, serta dilakukan uji kelompok kecil. Hasil validasi ahli materi adalah sebesar  84,38% dan masuk dalam kategori cukup valid, sedangkan hasil dari validasi ahli media pembelajaran sebesar 94,16% dengan kategori valid. Selanjutnya uji coba kelompok kecil memperoleh hasil 82% dengan kategori cukup valid. Hasil validasi berupa data kuantitatif dan kualitatif digunakan untuk merevisi modul sehingga modul semakin baik.

  19. Behavioral and biological effects of autonomous versus scheduled mission management in simulated space-dwelling groups

    Science.gov (United States)

    Roma, Peter G.; Hursh, Steven R.; Hienz, Robert D.; Emurian, Henry H.; Gasior, Eric D.; Brinson, Zabecca S.; Brady, Joseph V.

    2011-05-01

    Logistical constraints during long-duration space expeditions will limit the ability of Earth-based mission control personnel to manage their astronaut crews and will thus increase the prevalence of autonomous operations. Despite this inevitability, little research exists regarding crew performance and psychosocial adaptation under such autonomous conditions. To this end, a newly-initiated study on crew management systems was conducted to assess crew performance effectiveness under rigid schedule-based management of crew activities by Mission Control versus more flexible, autonomous management of activities by the crews themselves. Nine volunteers formed three long-term crews and were extensively trained in a simulated planetary geological exploration task over the course of several months. Each crew then embarked on two separate 3-4 h missions in a counterbalanced sequence: Scheduled, in which the crews were directed by Mission Control according to a strict topographic and temporal region-searching sequence, and Autonomous, in which the well-trained crews received equivalent baseline support from Mission Control but were free to explore the planetary surface as they saw fit. Under the autonomous missions, performance in all three crews improved (more high-valued geologic samples were retrieved), subjective self-reports of negative emotional states decreased, unstructured debriefing logs contained fewer references to negative emotions and greater use of socially-referent language, and salivary cortisol output across the missions was attenuated. The present study provides evidence that crew autonomy may improve performance and help sustain if not enhance psychosocial adaptation and biobehavioral health. These controlled experimental data contribute to an emerging empirical database on crew autonomy which the international astronautics community may build upon for future research and ultimately draw upon when designing and managing missions.

  20. Ion Propulsion Module (IPM) technology readiness assessment: 1985 Halley's Comet rendezvous mission

    Science.gov (United States)

    West, J.

    1977-01-01

    An assessment of the risk of utilizing ion propulsion to perform a rendezvous mission with Halley's comet in 1985 is presented, and consideration recommendations for reducing identified risks to the lowest possible level at project start in October 1978 were made.

  1. Modulation of radiosensitivity of biological systems by medicinal herbs

    International Nuclear Information System (INIS)

    Goyal, P.K.

    2012-01-01

    The global environmental pollution is responsible for the exposure of living beings to the influence of various technogenic factors, including ionizing radiation. Exposure to such radiation represents a genuine, increasing threat to mankind and our environment. The steadily increasing applications of radiation in clinical practice, industrial and agricultural activities, residual radio-activity resulting from nuclear test explosions, have a measurable impact contributing to significant radiation hazards in humans. Further, the proliferation of terrorism and asymmetric warfare in the 21st century has rendered the modern world a dangerous place to live and work. With the realization of deleterious effects of ionizing radiation, a need was felt to protect human beings against these harmful effects by using physical and/or chemical means. Many chemical compounds have been tested for radio protective action but their practical applicability remained limited owing to their inherent toxicity at the optimum dose level. Various plants have been used for various ailments in humans since time immemorial, and herbal preparations have usually been considered safe and less toxic than the synthetic compounds. Therefore, screening of natural products present a major avenue for the discovery of new radio protective drugs and such products have drawn the attention of investigators during the last two decades. The Indian system of medicine employs a large number of plants and some of these herbals viz. The extracts of certain medicinal plant like Amla (Emblica officinalis), Rosemary (Rosemary officinalis), Methi (Trigonella foenum graecum) sapthaparna (Alstonia scholaris), Bael (Aegle inarmelos), Bhumi amla (Phyllanthus niruri), Jamun (Syzgium cumini), Gloe (Tinospora cordifolia) have been trialed in this laboratory for their radio protective action in various biological systems of mammals. The extracts of various parts of such plants have appreciable DRF on the basis of survival

  2. Cooperative Learning and Group Educational Modules: Effects on Cognitive Achievement of High School Biology Students.

    Science.gov (United States)

    Watson, Scott B.

    1991-01-01

    Reports a study examining the effects of cooperative learning and self-instructional packets--"Group Educational Modules" (GEM)--on the achievement of biology students. Significant differences in achievement (as compared to control groups) were found for students using GEM materials and students in cooperative learning situations. (PR)

  3. Reflections on Supporting a Visually Impaired Student Complete a Biological Psychology Module

    Science.gov (United States)

    Betts, Lucy R.; Cross, Amanda

    2010-01-01

    While there are a number of technologies that have been used, with varying levels of success, to support visually impaired students, the purpose of this article is to reflect upon the authors' experiences of supporting a visually impaired student through a nine-month level two undergraduate biological psychology module. The authors developed a…

  4. Introducing Systems Biology to Bioscience students through mathematical modelling. A practical module

    Directory of Open Access Journals (Sweden)

    Néstor V. Torres Darias

    2013-11-01

    Full Text Available Systems Biology, one of the current approaches to the understanding of living things, aims to understand the behaviour of living systems through the creation of mathematical models that integrate the available knowledge of the system’s component parts and the relations among them. Accordingly, model building should play a central part in any biology degree program. One difficulty that we face when confronted with this task, however, is that the mathematical background of undergraduate students is very often deficient in essential concepts required for dynamic mathematical modelling. In this practical module, students are introduced to the basic techniques of mathematical modelling and computer simulation from a Systems Biology perspective.

  5. In Situ Biological Contamination Studies of the Moon: Implications for Future Planetary Protection and Life Detection Missions

    Science.gov (United States)

    Glavin, Daniel P.; Dworkin, Jason P.; Lupisella, Mark; Kminek, Gerhard; Rummel, John D.

    2010-01-01

    NASA and ESA have outlined visions for solar system exploration that will include a series of lunar robotic precursor missions to prepare for, and support a human return to the Moon, and future human exploration of Mars and other destinations. One of the guiding principles for exploration is to pursue compelling scientific questions about the origin and evolution of life. The search for life on objects such as Mars will require that all spacecraft and instrumentation be sufficiently cleaned and sterilized prior to launch to ensure that the scientific integrity of extraterrestrial samples is not jeopardized by terrestrial organic contamination. Under the Committee on Space Research's (COSPAR's) current planetary protection policy for the Moon, no sterilization procedures are required for outbound lunar spacecraft, nor is there yet a planetary protection category for human missions. Future in situ investigations of a variety of locations on the Moon by highly sensitive instruments designed to search for biologically derived organic compounds would help assess the contamination of the Moon by lunar spacecraft. These studies could also provide valuable "ground truth" data for Mars sample return missions and help define planetary protection requirements for future Mars bound spacecraft carrying life detection experiments. In addition, studies of the impact of terrestrial contamination of the lunar surface by the Apollo astronauts could provide valuable data to help refine future Mars surface exploration plans for a human mission to Mars.

  6. Development and Assessment of Modules to Integrate Quantitative Skills in Introductory Biology Courses

    Science.gov (United States)

    Hoffman, Kathleen; Leupen, Sarah; Dowell, Kathy; Kephart, Kerrie; Leips, Jeff

    2016-01-01

    Redesigning undergraduate biology courses to integrate quantitative reasoning and skill development is critical to prepare students for careers in modern medicine and scientific research. In this paper, we report on the development, implementation, and assessment of stand-alone modules that integrate quantitative reasoning into introductory biology courses. Modules are designed to improve skills in quantitative numeracy, interpreting data sets using visual tools, and making inferences about biological phenomena using mathematical/statistical models. We also examine demographic/background data that predict student improvement in these skills through exposure to these modules. We carried out pre/postassessment tests across four semesters and used student interviews in one semester to examine how students at different levels approached quantitative problems. We found that students improved in all skills in most semesters, although there was variation in the degree of improvement among skills from semester to semester. One demographic variable, transfer status, stood out as a major predictor of the degree to which students improved (transfer students achieved much lower gains every semester, despite the fact that pretest scores in each focus area were similar between transfer and nontransfer students). We propose that increased exposure to quantitative skill development in biology courses is effective at building competency in quantitative reasoning. PMID:27146161

  7. Cosmo Cassette: A Microfluidic Microgravity Microbial System For Synthetic Biology Unit Tests and Satellite Missions

    Science.gov (United States)

    Berliner, Aaron J.

    2013-01-01

    Although methods in the design-build-test life cycle of the synthetic biology field have grown rapidly, the expansion has been non-uniform. The design and build stages in development have seen innovations in the form of biological CAD and more efficient means for building DNA, RNA, and other biological constructs. The testing phase of the cycle remains in need of innovation. Presented will be both a theoretical abstraction of biological measurement and a practical demonstration of a microfluidics-based platform for characterizing synthetic biological phenomena. Such a platform demonstrates a design of additive manufacturing (3D printing) for construction of a microbial fuel cell (MFC) to be used in experiments carried out in space. First, the biocompatibility of the polypropylene chassis will be demonstrated. The novel MFCs will be cheaper, and faster to make and iterate through designs. The novel design will contain a manifold switchingdistribution system and an integrated in-chip set of reagent reservoirs fabricated via 3D printing. The automated nature of the 3D printing yields itself to higher resolution switching valves and leads to smaller sized payloads, lower cost, reduced power and a standardized platform for synthetic biology unit tests on Earth and in space. It will be demonstrated that the application of unit testing in synthetic biology will lead to the automatic construction and validation of desired constructs. Unit testing methodologies offer benefits of preemptive problem identification, change of facility, simplicity of integration, ease of documentation, and separation of interface from implementation, and automated design.

  8. The Impact of Mission Profile Models on the Predicted Lifetime of IGBT Modules in the Modular Multilevel Converter

    DEFF Research Database (Denmark)

    Zhang, Yi; Wang, Huai; Wang, Zhongxu

    2017-01-01

    The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made to the lif......The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made...... and electrical power modeling methods on the estimated lifetime of IGBT modules in an MMC for offshore wind power application. In a 30 MW MMC case study, an annual wind speed profile with a resolution of 1 s/data, 10 minute/data, and 1 hour/data are considered, respectively. A method to re-generate higher...... used in the MMC, resulting in significant differences. The study serves as a first step to quantify the impact of mission profile modeling on lifetime prediction, and to provide a guideline on mission profile collection for the presented application....

  9. Development and Assessment of Modules to Integrate Quantitative Skills in Introductory Biology Courses.

    Science.gov (United States)

    Hoffman, Kathleen; Leupen, Sarah; Dowell, Kathy; Kephart, Kerrie; Leips, Jeff

    2016-01-01

    Redesigning undergraduate biology courses to integrate quantitative reasoning and skill development is critical to prepare students for careers in modern medicine and scientific research. In this paper, we report on the development, implementation, and assessment of stand-alone modules that integrate quantitative reasoning into introductory biology courses. Modules are designed to improve skills in quantitative numeracy, interpreting data sets using visual tools, and making inferences about biological phenomena using mathematical/statistical models. We also examine demographic/background data that predict student improvement in these skills through exposure to these modules. We carried out pre/postassessment tests across four semesters and used student interviews in one semester to examine how students at different levels approached quantitative problems. We found that students improved in all skills in most semesters, although there was variation in the degree of improvement among skills from semester to semester. One demographic variable, transfer status, stood out as a major predictor of the degree to which students improved (transfer students achieved much lower gains every semester, despite the fact that pretest scores in each focus area were similar between transfer and nontransfer students). We propose that increased exposure to quantitative skill development in biology courses is effective at building competency in quantitative reasoning. © 2016 K. Hoffman, S. Leupen, et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. Brushing Your Spacecrafts Teeth: A Review of Biological Reduction Processes for Planetary Protection Missions

    Science.gov (United States)

    Pugel, D.E. (Betsy); Rummel, J. D.; Conley, C. A.

    2017-01-01

    Much like keeping your teeth clean, where you brush away biofilms that your dentist calls plaque, there are various methods to clean spaceflight hardware of biological contamination, known as biological reduction processes. Different approaches clean your hardwares teeth in different ways and with different levels of effectiveness. We know that brushing at home with a simple toothbrush is convenient and has a different level of impact vs. getting your teeth cleaned at the dentist. In the same way, there are some approaches to biological reduction that may require simple tools or more complex implementation approaches (think about sonicating or just soaking your dentures, vs. brushing them). There are also some that are more effective for different degrees of cleanliness and still some that have materials compatibility concerns. In this article, we review known and NASA-certified approaches for biological reduction, pointing out materials compatibility concerns and areas where additional research is needed.

  11. Biological design principles of complex feedback modules in the E. coli ammonia assimilation system.

    Science.gov (United States)

    Masaki, Koichi; Maeda, Kazuhiro; Kurata, Hiroyuki

    2012-01-01

    To synthesize natural or artificial life, it is critically important to understand the design principles of how biochemical networks generate particular cellular functions and evolve complex systems in comparison with engineering systems. Cellular systems maintain their robustness in the face of perturbations arising from environmental and genetic variations. In analogy to control engineering architectures, the complexity of modular structures within a cell can be attributed to the necessity of achieving robustness. To reveal such biological design, the E. coli ammonia assimilation system is analyzed, which consists of complex but highly structured modules: the glutamine synthetase (GS) activity feedback control module with bifunctional enzyme cascades for catalyzing reversible reactions, and the GS synthesis feedback control module with positive and negative feedback loops. We develop a full-scale dynamic model that unifies the two modules, and we analyze its robustness and fine tuning with respect to internal and external perturbations. The GS activity control is added to the GS synthesis module to improve its transient response to ammonia depletion, compensating the tradeoffs of each module, but its robustness to internal perturbations is lost. These findings suggest some design principles necessary for the synthesis of life.

  12. [Comparison of biological functional assessment in intensity-modulated radiotherapy: two-dimensional study].

    Science.gov (United States)

    Dejean, C; Lemosquet, A; Lefkopoulos, D; Touboul, E

    2001-12-01

    Modulated intensity dose distributions are obtained by inverse planning. It requires an inversion algorithm and an objective function that can be physical or biological. The biological objective functions aim at quantifying the probability of the favourable end of the treatment. The inversion algorithm used is analytical and is based on the mathematical analysis of the singular values decomposition. It proposes as many solutions as there are elementary beams. From the Tumour Control Probability, Normal Tissue Complication Probabilities and complication free tumour control, three biological assessment functions of the proposed solutions are compared with the least square difference between the prescribed and obtained dose distributions. We used a simplified irradiation configuration: Brahme's dose prescription (2D modelling of a prostate) and 9 beams (1D). The choice by mean of biological criterion of the optimal solution makes it possible to increase the average dose in the tumour, so as its homogeneity compared to physical optimisation. Conversely, the organs at risk are then less protected. The laying down of relevant constraints makes it possible to obtain satisfactory dose distributions. Concerning the validity of the models and data used, some limitations appear. At present time, it seems to exclude the use in clinical routine of an only biological optimisation. The future availability of new biological data will allow the development and in particular the clinical use of biological optimisation.

  13. Assessing an effective undergraduate module teaching applied bioinformatics to biology students.

    Science.gov (United States)

    Madlung, Andreas

    2018-01-01

    Applied bioinformatics skills are becoming ever more indispensable for biologists, yet incorporation of these skills into the undergraduate biology curriculum is lagging behind, in part due to a lack of instructors willing and able to teach basic bioinformatics in classes that don't specifically focus on quantitative skill development, such as statistics or computer sciences. To help undergraduate course instructors who themselves did not learn bioinformatics as part of their own education and are hesitant to plunge into teaching big data analysis, a module was developed that is written in plain-enough language, using publicly available computing tools and data, to allow novice instructors to teach next-generation sequence analysis to upper-level undergraduate students. To determine if the module allowed students to develop a better understanding of and appreciation for applied bioinformatics, various tools were developed and employed to assess the impact of the module. This article describes both the module and its assessment. Students found the activity valuable for their education and, in focus group discussions, emphasized that they saw a need for more and earlier instruction of big data analysis as part of the undergraduate biology curriculum.

  14. The Marshall Space Flight Center development of mirror modules for the ART-XC instrument aboard the Spectrum-Roentgen-Gamma mission

    Science.gov (United States)

    Gubarev, M.; Ramsey, B.; O'Dell, S. L.; Elsner, R.; Kilaru, K.; McCracken, J.; Pavlinsky, M.; Tkachenko, A.; Lapshov, I.

    2012-09-01

    The Marshall Space Flight Center (MSFC) is developing x-ray mirror modules for the ART-XC instrument on board the Spectrum-Roentgen-Gamma Mission under a Reimbursable Agreement between NASA and the Russian Space Research Institute (IKI.) ART-XC will consist of seven co-aligned x-ray mirror modules with seven corresponding CdTe focal plane detectors. Currently, four of the modules are being fabricated by the Marshall Space Flight Center (MSFC.) Each MSFC module consist of 28 nested Ni/Co thin shells giving an effective area of 65 cm2 at 8 keV, response out to 30 keV, and an angular resolution of 45 arcsec or better HPD. Delivery of these modules to the IKI is scheduled for summer 2013. We present a status of the ART x-ray modules development at the MSFC.

  15. Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module.

    Science.gov (United States)

    McIlrath, Victoria; Trye, Alice; Aguanno, Ann

    2015-06-18

    Undergraduate biology students are required to learn, understand and apply a variety of cellular and molecular biology concepts and techniques in preparation for biomedical, graduate and professional programs or careers in science. To address this, a simple laboratory module was devised to teach the concepts of cell division, cellular communication and cancer through the application of animal cell culture techniques. Here the mouse mammary tumor (MMT) cell line is used to model for breast cancer. Students learn to grow and characterize these animal cells in culture and test the effects of traditional and non-traditional chemotherapy agents on cell proliferation. Specifically, students determine the optimal cell concentration for plating and growing cells, learn how to prepare and dilute drug solutions, identify the best dosage and treatment time course of the antiproliferative agents, and ascertain the rate of cell death in response to various treatments. The module employs both a standard cell counting technique using a hemocytometer and a novel cell counting method using microscopy software. The experimental procedure lends to open-ended inquiry as students can modify critical steps of the protocol, including testing homeopathic agents and over-the-counter drugs. In short, this lab module requires students to use the scientific process to apply their knowledge of the cell cycle, cellular signaling pathways, cancer and modes of treatment, all while developing an array of laboratory skills including cell culture and analysis of experimental data not routinely taught in the undergraduate classroom.

  16. The modulation of motor control by imitating non-biological motions: a study about motor resonance.

    Science.gov (United States)

    Miyawaki, Yu; Yamamoto, Taisei

    2018-01-01

    [Purpose] Sensorimotor experience modulates motor resonance, such as motor interference, which occurs when observing others' movements; however, it is unclear how motor resonance is modulated by intentionally imitating others' movements. This study examined the effects of imitation experience on subsequent motor resonance. [Subjects and Methods] Twenty-seven healthy participants performed horizontal arm movements while observing non-biological, incongruent (vertical) movements of a visual stimulus (triangle object) in pre- and post-test procedures. Thirteen participants in the imitation group imitated vertical movements (non-biological motion) of the triangle object between pre- and post-test procedures and fourteen participants in the non-imitation group observed that. [Results] Variance in the executed movements was measured as an index of motor resonance. Although there was no significant difference in the non-imitation group, there was a significantly smaller variance for post-test compared to pre-test in the imitation group. [Conclusion] Motor resonance was inhibited by intentionally imitating non-biological motions. Imitating movements different from one's own motor property might inhibit subsequent motor resonance. This finding might be applied to selectively using motor resonance as a form of rehabilitation.

  17. Aloe vera: Potential candidate in health management via modulation of biological activities

    Science.gov (United States)

    Rahmani, Arshad H.; Aldebasi, Yousef H.; Srikar, Sauda; Khan, Amjad A.; Aly, Salah M.

    2015-01-01

    Treatment based on natural products is rapidly increasing worldwide due to the affordability and fewer side effects of such treatment. Various plants and the products derived from them are commonly used in primary health treatment, and they play a pivotal role in the treatment of diseases via modulation of biochemical and molecular pathways. Aloe vera, a succulent species, produces gel and latex, plays a therapeutic role in health management through antioxidant, antitumor, and anti-inflammatory activities, and also offers a suitable alternative approach for the treatment of various types of diseases. In this review, we summarize the possible mechanism of action and the therapeutic implications of Aloe vera in health maintenance based on its modulation of various biological activities. PMID:26392709

  18. Tactile input and empathy ability modulate the perception of ambiguous biological motion

    Directory of Open Access Journals (Sweden)

    Hörmetjan eYiltiz

    2015-02-01

    Full Text Available Evidence has shown that task-irrelevant auditory cues can bias perceptual decisions regarding directional information associated with biological motion, as indicated in perceptual tasks using point-light walkers (PLWs (Brooks et al., 2007. In the current study, we extended the investigation of cross-modal influences to the tactile domain by asking how tactile input resolves perceptual ambiguity in visual apparent motion, and how empathy ability plays a role in this cross-modal interaction. In Experiment 1, we simulated the tactile feedback on the observers’ fingertips when the (upright or inverted PLWs (comprised of either all red or all green dots were walking (leftwards or rightwards. The temporal periods between tactile events and critical visual events (the PLW’s feet hitting the ground were manipulated so that the tap could lead, synchronize, or lag with the visual foot-hitting-ground event. We found that the temporal structures between tactile (feedback and visual (hitting events systematically modulate the directional perception for upright PLWs, making either leftwards or rightwards more dominant. However, this temporal modulation effect was absent for inverted PLWs. In Experiment 2, we examined how empathy ability modulates cross-modal capture. Instead of generating tactile feedback on participant’s fingertips, we gave taps on their ankles and presented the PLWs with motion directions of approaching (facing towards observer/receding (facing away from observer to resemble normal walking postures. With the same temporal structure, we found that individuals with higher empathic ability were more subject to perceptual bias in the presence of tactile feedback. Taken together, our findings showed that task-irrelevant tactile input can resolve the otherwise ambiguous perception of the directional information of biological motion, whereas cross-modal modulation was mediated by higher level social-cognitive factors, including empathic

  19. Mission and Sustainability of Informatics for Integrating Biology and the Bedside (i2b2).

    Science.gov (United States)

    Murphy, Shawn; Wilcox, Adam

    2014-01-01

    A visible example of a successfully disseminated research project in the healthcare space is Informatics for Integrating Biology and the Bedside, or i2b2. The project serves to provide the software that can allow a researcher to do direct, self-serve queries against the electronic healthcare data form a hospital. The goals of these queries are to find cohorts of patients that fit specific profiles, while providing for patient privacy and discretion. Sustaining this resource and keeping its direction has always been a challenge, but ever more so as the ten year National Centers for Biomedical Computing (NCBCs) sunset their funding. Building on the i2b2 structures has helped the dissemination plans for grants leveraging it because it is a disseminated national resource. While this has not directly increased the support of i2b2 internally, it has increased the ability of institutions to leverage the resource and generally leads to increased institutional support. The successful development, use, and dissemination i2b2 has been significant in clinical research and informatics. Its evolution has been from a local research data infrastructure to one disseminated more broadly than any other product of the National Centers for Biomedical Computing, and an infrastructure spawning larger investments than were originally used to create it. Throughout this, there were two main lessons about the benefits of dissemination: that people have great creativity in utilizing a resource in different ways and that broader system use can make the system more robust. One option for long-term sustainability of the central authority would be to translate the function to an industry partner. Another option currently being pursued is to create a foundation that would be a central authority for the project. Over the past 10 years, i2b2 has risen to be an important staple in the toolkit of health care researchers. There are now over 110 hospitals that use i2b2 for research. This open

  20. The main changes in plant exposured during space flight missions and prospectives of biological studies on ISS

    Science.gov (United States)

    Nechitailo, Galina S.; Kuznetsov, Anatoli

    The fundamental result of biological investigations with plants in space flight is an experimen-tal evidence of vegetative growth from seeds to harvest, with passing of all those stages of development when the plant can be used for food. The changes of plant observed after space flight mission gives a knowledge, which has to be used for precise selection of the plants for future space missions. The experimental investigation of the plants under space flight condi-tions showed that the germinations ability, rate of growth and biometric parameters decrease in comparison with Earth plants. The first two of these factors can be caused by the influence of specific cultivation in space, but the third factor is caused by the influence of space flight conditions, in particular, microgravity. The investigations of germination, plants deaths at var-ious stages of growth, survival probability, and recessive mutations indicated an impairment of genetic apparatus of meristem cells, which results the lethal effect at various stages of develop-ment. The density of paramagnetic centers in seeds was measured in order to determine the free radical concentration under space flight conditions. The concentration of paramagnetic centers is higher for plants with high density of these centers initially. Perhaps, the observed genetic effects in plants under space flight conditions are connected with free radicals. The changes are observed in cells of the plants. The changes included twist, contraction and deformation of the cell walls, curvature and loose arrangement of lamellae in chloroplasts, break of outer membrane of mitochondria and disappearance of mitochondria cristae. A large number of stach grains is observed in chloroplasts. The seeds of various plants were successfully used in space flights: welsh onion, wheat, peas, maize, barley, tomatoes, etc. Mostly stabe plants to space flight factors are found as peas, wheat and tomatoes. Ten generation of wheat and tomatoues exposed in

  1. The C.E.B.A. Mini Module on the STS-107 Mission: Data of Ground Experiments and Preliminary Results of the third Spaceflight of an Artificial Aquatic Ecosystem

    Science.gov (United States)

    Bluem, V.; Paris, F.; Bungart, S.

    The C.E.B.A.S MINI MODULE is the miniaturized version of an artificial aquatic ecosystem consisting of four subcomponents: a ZOOLOGICAL COMPONENT (aquarium for animals), a BOTANICAL COMPONENT (higher water plant bioreactor), a MICROBIAL COMPONENT (bacteria filter) and an ELECTRONICAL COMPONENT (data acquisition, control unit). It has a total volume of 8.6 liters and contains the ovoviviparous teleost Xiphophorus helleri (swordtail), larvae of the ovuliparous cichlid fish Oreochromis mossambicus, the pulmonate water snail Biomphalaria glabrata, the rootless (non-graivitropic) higher water plant Ceratophyllum demersum (hornweed) and special strains of ammonia oxidizing bacteria. This device was already flown twice successfully in space with the space shuttle missions STS- 89 and STS-90 (NEUROLAB) in 1998. It will fly a third time with the STS-107-mission the launch of which has been repeatedly shifted December 222, April 2001, October 2001) and is now finally scheduled for June 2002. The main focus of scientific interest in the past missions were system performance, reproductive biology (reproductive function of adult females including endocrine system, fertilization, gonadal development in juveniles), vestibular and immunological research in X. helleri, embryology and shell formation in B. glabrata, general morphology and physiology of C. demersum and groth rates of the bacteria. The standard load of the system were 4 adult and 200 neonate X. helleri, 30 adult B. glabrata and 30 g of C. demersum. The evaluation of these experiments showed that all reproductive functions and the immune system of the fishes snails remained undisturbed in space, that the snails developed normally and exhibited no disturbance of shell formation and that the plants showed growth and photosynthesis rates comparable to those on Earth. So, as a logical continuation, the main topics for the STS-107 mission are the remaining important questions in X. helleri biology: puberty, male sexual

  2. Biological-based optimization and volumetric modulated arc therapy delivery for stereotactic body radiation therapy

    International Nuclear Information System (INIS)

    Diot, Quentin; Kavanagh, Brian; Timmerman, Robert; Miften, Moyed

    2012-01-01

    Purpose: To describe biological-based optimization and Monte Carlo (MC) dose calculation-based treatment planning for volumetric modulated arc therapy (VMAT) delivery of stereotactic body radiation therapy (SBRT) in lung, liver, and prostate patients. Methods: Optimization strategies and VMAT planning parameters using a biological-based optimization MC planning system were analyzed for 24 SBRT patients. Patients received a median dose of 45 Gy [range, 34-54 Gy] for lung tumors in 1-5 fxs and a median dose of 52 Gy [range, 48-60 Gy] for liver tumors in 3-6 fxs. Prostate patients received a fractional dose of 10 Gy in 5 fxs. Biological-cost functions were used for plan optimization, and its dosimetric quality was evaluated using the conformity index (CI), the conformation number (CN), the ratio of the volume receiving 50% of the prescription dose over the planning target volume (Rx/PTV50). The quality and efficiency of the delivery were assessed according to measured quality assurance (QA) passing rates and delivery times. For each disease site, one patient was replanned using physical cost function and compared to the corresponding biological plan. Results: Median CI, CN, and Rx/PTV50 for all 24 patients were 1.13 (1.02-1.28), 0.79 (0.70-0.88), and 5.3 (3.1-10.8), respectively. The median delivery rate for all patients was 410 MU/min with a maximum possible rate of 480 MU/min (85%). Median QA passing rate was 96.7%, and it did not significantly vary with the tumor site. Conclusions: VMAT delivery of SBRT plans optimized using biological-motivated cost-functions result in highly conformal dose distributions. Plans offer shorter treatment-time benefits and provide efficient dose delivery without compromising the plan conformity for tumors in the prostate, lung, and liver, thereby improving patient comfort and clinical throughput. The short delivery times minimize the risk of patient setup and intrafraction motion errors often associated with long SBRT treatment

  3. Error Analysis of the Shuttle Orbital Maneuvering System P-V-T Propellant Gaging Module. Mission Planning, Mission Analysis and Software Formulation

    Science.gov (United States)

    Duhon, D. D.

    1975-01-01

    An investigation of the shuttle orbital maneuvering system (OMS) pressure-volume-temperature (P-V-T) propellant gaging module has revealed that the gaging errors due to the combined effects of random instrumentation measurement errors, propellant loading uncertainties, and simplifying assumptions in the software are non-linear over the range of the usable propellant quantity gage (0-100%), with the largest error being at the zero point. When the OMS propellant tanks in the orbiter vehicle pods are filled to contain 100% of the maximum usable propellant, the gaging error at the zero point was determined to be 9.5% for the fuel and 9.5% for the oxidizer. When the OMS propellant tanks initially contain 50% of the maximum usable propellant, the largest gaging error is still 9.5% for the fuel and 9.5% for the oxidizer.

  4. Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity

    Directory of Open Access Journals (Sweden)

    Stephan Menzel

    2018-03-01

    Full Text Available Adenosine triphosphate (ATP and nicotinamide adenine dinucleotide (NAD+ are released as danger signals from cells during infection and sterile inflammation. In the extracellular compartment ATP is converted by CD39, CD73, and other ecto-enzymes into metabolites that modulate the activity of T cells and macrophages. While ATP mediates pro-inflammatory signals via P2X7 and other P2 receptors, adenosine triggers anti-inflammatory signaling via the adenosine 2a receptor (Adora2a and other P1 receptors. The latter also plays a role in maintaining an immunosuppressive tumor microenvironment. NAD+ is converted by CD38, CD203 and other ecto-enzymes to the Ca2+ mobilizing messengers cyclic ADP-ribose and ADP-ribose, and to adenosine. Recent findings on the roles of CD38, CD39, CD73, CD203, P2X7, and Adora2a in inflammation and immunity underscore the potential of these proteins as drug targets. However, available small molecule inhibitors often lack specificity and mediate unwanted off-target toxicity. Nanobodies – single domain antibodies derived from heavy chain antibodies that naturally occur in camelids – display a propensity to bind functional epitopes not accessible to conventional antibodies. Like conventional antibodies, nanobodies and nanobody-based biologics are highly specific and have well-understood, tunable in vivo pharmacodynamics with little if any toxicity. Nanobodies thus represent attractive alternatives to small molecule inhibitors for modulating purinergic signaling in inflammation and immunity. Here we review recent progress made in developing nanobodies against key targets of purinergic signaling.

  5. Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

    Science.gov (United States)

    Menzel, Stephan; Schwarz, Nicole; Haag, Friedrich; Koch-Nolte, Friedrich

    2018-01-01

    Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD + ) are released as danger signals from cells during infection and sterile inflammation. In the extracellular compartment ATP is converted by CD39, CD73, and other ecto-enzymes into metabolites that modulate the activity of T cells and macrophages. While ATP mediates pro-inflammatory signals via P2X7 and other P2 receptors, adenosine triggers anti-inflammatory signaling via the adenosine 2a receptor (Adora2a) and other P1 receptors. The latter also plays a role in maintaining an immunosuppressive tumor microenvironment. NAD + is converted by CD38, CD203 and other ecto-enzymes to the Ca 2+ mobilizing messengers cyclic ADP-ribose and ADP-ribose, and to adenosine. Recent findings on the roles of CD38, CD39, CD73, CD203, P2X7, and Adora2a in inflammation and immunity underscore the potential of these proteins as drug targets. However, available small molecule inhibitors often lack specificity and mediate unwanted off-target toxicity. Nanobodies - single domain antibodies derived from heavy chain antibodies that naturally occur in camelids - display a propensity to bind functional epitopes not accessible to conventional antibodies. Like conventional antibodies, nanobodies and nanobody-based biologics are highly specific and have well-understood, tunable in vivo pharmacodynamics with little if any toxicity. Nanobodies thus represent attractive alternatives to small molecule inhibitors for modulating purinergic signaling in inflammation and immunity. Here we review recent progress made in developing nanobodies against key targets of purinergic signaling.

  6. JAK/STAT signalling--an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology.

    Science.gov (United States)

    Blätke, Mary Ann; Dittrich, Anna; Rohr, Christian; Heiner, Monika; Schaper, Fred; Marwan, Wolfgang

    2013-06-01

    Mathematical models of molecular networks regulating biological processes in cells or organisms are most frequently designed as sets of ordinary differential equations. Various modularisation methods have been applied to reduce the complexity of models, to analyse their structural properties, to separate biological processes, or to reuse model parts. Taking the JAK/STAT signalling pathway with the extensive combinatorial cross-talk of its components as a case study, we make a natural approach to modularisation by creating one module for each biomolecule. Each module consists of a Petri net and associated metadata and is organised in a database publically accessible through a web interface (). The Petri net describes the reaction mechanism of a given biomolecule and its functional interactions with other components including relevant conformational states. The database is designed to support the curation, documentation, version control, and update of individual modules, and to assist the user in automatically composing complex models from modules. Biomolecule centred modules, associated metadata, and database support together allow the automatic creation of models by considering differential gene expression in given cell types or under certain physiological conditions or states of disease. Modularity also facilitates exploring the consequences of alternative molecular mechanisms by comparative simulation of automatically created models even for users without mathematical skills. Models may be selectively executed as an ODE system, stochastic, or qualitative models or hybrid and exported in the SBML format. The fully automated generation of models of redesigned networks by metadata-guided modification of modules representing biomolecules with mutated function or specificity is proposed.

  7. Tactile input and empathy modulate the perception of ambiguous biological motion.

    Science.gov (United States)

    Yiltiz, Hörmetjan; Chen, Lihan

    2015-01-01

    Evidence has shown that task-irrelevant auditory cues can bias perceptual decisions regarding directional information associated with biological motion, as indicated in perceptual tasks using point-light walkers (PLWs) (Brooks et al., 2007). In the current study, we extended the investigation of cross-modal influences to the tactile domain by asking how tactile input resolves perceptual ambiguity in visual apparent motion, and how empathy plays a role in this cross-modal interaction. In Experiment 1, we simulated the tactile feedback on the observers' fingertips when the (upright or inverted) PLWs (comprised of either all red or all green dots) were walking (leftwards or rightwards). The temporal periods between tactile events and critical visual events (the PLW's feet hitting the ground) were manipulated so that the tap could lead, synchronize, or lag the visual foot-hitting-ground event. We found that the temporal structures between tactile (feedback) and visual (hitting) events systematically biases the directional perception for upright PLWs, making either leftwards or rightwards more dominant. However, this effect was absent for inverted PLWs. In Experiment 2, we examined how empathy modulates cross-modal capture. Instead of giving tactile feedback on participants' fingertips, we gave taps on their ankles and presented the PLWs with motion directions of approaching (facing toward observer)/receding (facing away from observer) to resemble normal walking postures. With the same temporal structure, we found that individuals with higher empathy were more subject to perceptual bias in the presence of tactile feedback. Taken together, our findings showed that task-irrelevant tactile input can resolve the otherwise ambiguous perception of the direction of biological motion, and this cross-modal bias was mediated by higher level social-cognitive factors, including empathy.

  8. Gas mission; Mission gaz

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    This preliminary report analyses the desirable evolutions of gas transport tariffing and examines some questions relative to the opening of competition on the French gas market. The report is made of two documents: a synthesis of the previous report with some recommendations about the tariffing of gas transport, about the modalities of network access to third parties, and about the dissociation between transport and trade book-keeping activities. The second document is the progress report about the opening of the French gas market. The first part presents the European problem of competition in the gas supply and its consequences on the opening and operation of the French gas market. The second part presents some partial syntheses about each topic of the mission letter of the Ministry of Economics, Finances and Industry: future evolution of network access tariffs, critical analysis of contractual documents for gas transport and delivery, examination of auxiliary services linked with the access to the network (modulation, balancing, conversion), consideration about the processing of network congestions and denied accesses, analysis of the metering dissociation between the integrated activities of gas operators. Some documents are attached in appendixes: the mission letter from July 9, 2001, the detailed analysis of the new temporary tariffs of GdF and CFM, the offer of methane terminals access to third parties, the compatibility of a nodal tariffing with the presence of three transport operators (GdF, CFM and GSO), the contract-type for GdF supply, and the contract-type for GdF connection. (J.S.)

  9. Spinal cordd biological safety comparison of intensity modulated radiotherapy and conventional radiation therapy

    International Nuclear Information System (INIS)

    Xilinbaoleri; Xu Wanlong; Chen Gang; Liu Hao; Wang Ruozheng; Bai Jingping

    2010-01-01

    Objective: To compare the spine intensity modulated radiation therapy (IMRT) and the conventional radiation therapy on the beagle spinal cord neurons, in order to prove the biological safety of IMRT of the spinal cord. Methods: Twelve selected purebred beagles were randomly divided into 2 groups. A beagle clinical model of tumor was mimiced in the ninth and tenth thoracic vertebrae. Then the beagles were irradiated by 2 different models of intensity modulated radiotherapy and conventional radiation therapy, with the total irradiation doses of 50 and 70 Gy. The samples of spinal cord were taken out from the same position of the nine and tenth thoracic vertebrae at the third month after radiation.All the samples were observed by the electron microscope, and the Fas and HSP70 expression in spinal cord neurons were evaluated by immunohistochemistry method. Terminal deoxynucleatidyl transferase mediated dUTP nick and labeling (TUNEL) technique was used to examine the apoptotic cells in the spinal cord. Results: The neurons in the spinal cord of IMRT group were mainly reversible injury, and those in the conventional radiation therapy were mainly apoptosis. Compared with the conventional radiation therapy group [50 Gy group, (7.3 ± 1.1)%; 70 Gy group, (11.3 ± 1.4)%], the apoptosis rate of the spinal cord neurons of the intensity modulated radiotherapy group [50 Gy group, (1.2 ± 0.7)%; 70 Gy group (2.5 ± 0.8)%] was much lower[(50 Gy group, t=0.022, P<0.05; 70 Gy group, t=0.017, P<0.05)]. The expression levels of Fas in the IMPT group (50 Gy group, 4.6 ± 0.8; 70 Gy group, 7.4 ± 1.1) were also much lowerthan those in the other group (50 Gy group, 15.1 ± 6.4; 70 Gy group, 19.3 ± 7.6. 50 Gy group, t=0.231, P<0.05; 70 Gy group, t=0.457, P<0.05), while the expression levels of HSP70 in the IMPT group (50 Gy group, 9.1 ± 0.8; 70 Gy group, 7.3 ± 1.4)were much higher than those in the conventional radiation therapy group (50 Gy group, 2.1 ± 0.9; 70 Gy group, 1.7 ± 0

  10. Space biology initiative program definition review. Trade study 6: Space Station Freedom/spacelab modules compatibility

    Science.gov (United States)

    Jackson, L. Neal; Crenshaw, John, Sr.; Davidson, William L.; Blacknall, Carolyn; Bilodeau, James W.; Stoval, J. Michael; Sutton, Terry

    1989-01-01

    The differences in rack requirements for Spacelab, the Shuttle Orbiter, and the United States (U.S.) laboratory module, European Space Agency (ESA) Columbus module, and the Japanese Experiment Module (JEM) of Space Station Freedom are identified. The feasibility of designing standardized mechanical, structural, electrical, data, video, thermal, and fluid interfaces to allow space flight hardware designed for use in the U.S. laboratory module to be used in other locations is assessed.

  11. Radiation efficacy and biological risk from whole-breast irradiation via intensity modulated radiation therapy (IMRT)

    Science.gov (United States)

    Desantis, David M.

    Radiotherapy is an established modality for women with breast cancer. During the delivery of external beam radiation to the breast, leakage, scattered x-rays from the patient and the linear accelerator also expose healthy tissues and organs outside of the breast, thereby increasing the patient's whole-body dose, which then increases the chance of developing a secondary, radiation-induced cancer. Generally, there are three IntensityModulated Radiotherapy (IMRT) delivery techniques from a conventional linear accelerator; forward planned (FMLC), inverse planned 'sliding window' (DMLC), and inverse planned 'step-and-shoot' (SMLC). The goal of this study was to determine which of these three techniques delivers an optimal dose to the breast with the least chance of causing a fatal, secondary, radiation-induced cancer. A conventional, non-IMRT, 'Wedge' plan also was compared. Computerized Tomography (CT) data sets for both a large and small sized patient were used in this study. With Varian's Eclipse AAA algorithm, the organ doses specified in the revised ICRP 60 publication were used to calculate the whole-body dose. Also, an anthropomorphic phantom was irradiated with thermoluminescent dosimeters (TLD) at each organ site for measured doses. The risk coefficient from the Biological Effects of Ionizing Radiation (BEIR) VII report of 4.69 x 10-2 deaths per Gy was used to convert whole-body dose to risk of a fatal, secondary, radiation-induced cancer. The FMLC IMRT delivered superior tumor coverage over the 3D conventional plan and the inverse DMLC or SMLC treatment plans delivered clinically equivalent tumor coverage. However, the FMLC plan had the least likelihood of inadvertently causing a fatal, secondary, radiation-induced cancer compared to the inverse DMLC, SMLC, and Wedge plans.

  12. Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation.

    Science.gov (United States)

    Caprioli, Giovanni; Mammoli, Valerio; Ricciutelli, Massimo; Sagratini, Gianni; Ubaldi, Massimo; Domi, Esi; Mennuni, Laura; Sabatini, Chiara; Galimberti, Chiara; Ferrari, Flora; Milia, Chiara; Comi, Eleonora; Lanza, Marco; Giannella, Mario; Pigini, Maria; Del Bello, Fabio

    2015-12-15

    Tolerance to opioid administration represents a serious medical alert in different chronic conditions. This study compares the effects of the imidazoline compounds 1, 2, and 3 on morphine tolerance in an animal model of inflammatory pain in the rat. 1, 2, and 3 have been selected in that, although bearing a common scaffold, preferentially bind to α2-adrenoceptors, imidazoline I2 receptors, or both systems, respectively. Such compounds have been tested in vivo by measuring the paw withdrawal threshold to mechanical pressure after complete Freund's adjuvant injection. To determine the ligand levels in rat plasma, an HPLC-mass spectrometry method has been developed. All the compounds significantly reduced the induction of morphine tolerance, showing different potency and duration of action. Indeed, the selective imidazoline I2 receptor interaction (2) restored the analgesic response by maintaining the same time-dependent profile observed after a single morphine administration. Differently, the selective α2C-adrenoceptor activation (1) or the combination between α2C-adrenoceptor activation and imidazoline I2 receptor engagement (3) promoted a change in the temporal profile of morphine analgesia by maintaining a mild but long lasting analgesic effect. Interestingly, the kinetics of compounds in rat plasma supported the pharmacodynamic data. Therefore, this study highlights that both peculiar biological profile and bioavailability of such ligands complement each other to modulate the reduction of morphine tolerance. Based on these observations, 1-3 can be considered useful leads in the design of new drugs able to turn off the undesired tolerance induced by opioids. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Preliminary reentry safety assessment of the General Purpose Heat Source module for the Cassini mission: Aerospace Nuclear Safety Program

    Science.gov (United States)

    Conn, D. W.; Brenza, P. T.

    1993-04-01

    As asked by the U.S. Department of Energy/Office of Special Applications, and in support of the Environmental Impact Statement for the Cassini mission, The Johns Hopkins University/Applied Physics Laboratory (JHU/APL) has conducted preliminary one dimensional ablation and thermal analyses of the General Purpose Heat Source (GPHS). The predicted earth entry conditions provided by the Jet Propulsion Laboratory (JPL) for a Cassini Venus - Venus - Earth - Jupiter gravity assist (VVEJGA) trajectory were used as initial conditions. The results of this study, which constitute the initial reentry analysis assessment leading to the Cassini Updated Safety Analysis Report (USAR), are discussed in this document.

  14. Preliminary reentry safety assessment of the General Purpose Heat Source module for the Cassini mission: Aerospace Nuclear Safety Program

    Energy Technology Data Exchange (ETDEWEB)

    Conn, D.W.; Brenza, P.T.

    1993-04-01

    As asked by the U. S. Department of Energy/Office of Special Applications, and in support of the Environmental Impact Statement for the Cassini mission, The Johns Hopkins University/Applied Physics Laboratory (JHU/APL) has conducted preliminary one-dimensional ablation and thermal analyses of the General Purpose Heat Source (GPHS). The predicted earth entry conditions provided by the Jet Propulsion Laboratory (JPL) for a Cassini Venus-Venus-Earth-Jupiter Gravity Assist (VVEJGA) trajectory were used as initial conditions. The results of this study which constitute the initial reentry analysis assessment leading to the Cassini Updated Safety, Analysis Report (USAR) are discussed in this document.

  15. Full Monte Carlo-Based Biologic Treatment Plan Optimization System for Intensity Modulated Carbon Ion Therapy on Graphics Processing Unit.

    Science.gov (United States)

    Qin, Nan; Shen, Chenyang; Tsai, Min-Yu; Pinto, Marco; Tian, Zhen; Dedes, Georgios; Pompos, Arnold; Jiang, Steve B; Parodi, Katia; Jia, Xun

    2018-01-01

    One of the major benefits of carbon ion therapy is enhanced biological effectiveness at the Bragg peak region. For intensity modulated carbon ion therapy (IMCT), it is desirable to use Monte Carlo (MC) methods to compute the properties of each pencil beam spot for treatment planning, because of their accuracy in modeling physics processes and estimating biological effects. We previously developed goCMC, a graphics processing unit (GPU)-oriented MC engine for carbon ion therapy. The purpose of the present study was to build a biological treatment plan optimization system using goCMC. The repair-misrepair-fixation model was implemented to compute the spatial distribution of linear-quadratic model parameters for each spot. A treatment plan optimization module was developed to minimize the difference between the prescribed and actual biological effect. We used a gradient-based algorithm to solve the optimization problem. The system was embedded in the Varian Eclipse treatment planning system under a client-server architecture to achieve a user-friendly planning environment. We tested the system with a 1-dimensional homogeneous water case and 3 3-dimensional patient cases. Our system generated treatment plans with biological spread-out Bragg peaks covering the targeted regions and sparing critical structures. Using 4 NVidia GTX 1080 GPUs, the total computation time, including spot simulation, optimization, and final dose calculation, was 0.6 hour for the prostate case (8282 spots), 0.2 hour for the pancreas case (3795 spots), and 0.3 hour for the brain case (6724 spots). The computation time was dominated by MC spot simulation. We built a biological treatment plan optimization system for IMCT that performs simulations using a fast MC engine, goCMC. To the best of our knowledge, this is the first time that full MC-based IMCT inverse planning has been achieved in a clinically viable time frame. Copyright © 2017 Elsevier Inc. All rights reserved.

  16. Using a Module-Based Laboratory to Incorporate Inquiry into a Large Cell Biology Course

    Science.gov (United States)

    Howard, David R.; Miskowski, Jennifer A.

    2005-01-01

    Because cell biology has rapidly increased in breadth and depth, instructors are challenged not only to provide undergraduate science students with a strong, up-to-date foundation of knowledge, but also to engage them in the scientific process. To these ends, revision of the Cell Biology Lab course at the University of Wisconsin-La Crosse was…

  17. 3 EXPOSE Missions - overview and lessons learned

    Science.gov (United States)

    Rabbow, E.; Willnekcer, R.; Reitz, G.; Aman, A.; Bman, B.; Cman, C.

    2011-10-01

    The International Space Station ISS provides a variety of external research platforms for experiments aiming at the utilization of space parameters like vacuum, temperature oscillation and in particular extraterrestrial short wavelength UV and ionizing radiation which cannot be simulated accurately in the laboratory. Three Missions, two past and one upcoming, will be presented. A family of astrobiological experimental ESA facilities called "EXPOSE" were and will be accommodated on these outside exposure platforms: on one of the external balconies of the European Columbus Module (EXPOSE-E) and on the URM-D platform on the Russian Zvezda Module (EXPOSE-R and EXPOSE-R2). Exobiological and radiation experiments, exposing chemical, biological and dosimetric samples to the harsh space environment are - and will be - accommodated on these facilities to increase our knowledge on the origin, evolution and distribution of life, on Earth and possibly beyond. The biological experiments investigate resistance and adaptation of organisms like bacteria, Achaea, fungi, lichens, plant seeds and small animals like mosquito larvae to extreme environmental conditions and underlying mechanisms like DNA repair. The organic chemical experiments analyse chemical reactions triggered by the extraterrestrial environment, especially short wavelength UV radiation, to better understand prebiotic chemistry. The facility is optimized to allow exposure of biological specimen and material samples under a variety of conditions, using optical filter systems. Environmental parameters like temperature and radiation are regularly recorded and down linked by telemetry. Two long term missions named according to their facility - EXPOSE-E and EXPOSE-R - are completed and a third mission is planned and currently prepared. Operations of all three missions including sample accommodation are performed by DLR. An overview of the two completed missions will be given including lessons learned as well as an outlook

  18. SpaCEM3: a software for biological module detection when data is incomplete, high dimensional and dependent.

    Science.gov (United States)

    Vignes, Matthieu; Blanchet, Juliette; Leroux, Damien; Forbes, Florence

    2011-03-15

    Among classical methods for module detection, SpaCEM(3) provides ad hoc algorithms that were shown to be particularly well adapted to specific features of biological data: high-dimensionality, interactions between components (genes) and integrated treatment of missingness in observations. The software, currently in its version 2.0, is developed in C++ and can be used either via command line or with the GUI under Linux and Windows environments. The SpaCEM(3) software, a documentation and datasets are available from http://spacem3.gforge.inria.fr/.

  19. Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

    Czech Academy of Sciences Publication Activity Database

    Gbelcová, H.; Rimpelová, S.; Knejzlík, Z.; Šáchová, Jana; Kolář, Michal; Strnad, Hynek; Repiska, V.; D'Acunto, C.W.; Ruml, T.; Vítek, L.

    2017-01-01

    Roč. 16, zima (2017), č. článku 250. ISSN 1476-511X R&D Projects: GA MZd(CZ) NT13112 Institutional support: RVO:68378050 Keywords : Farmesyl pyrophosphate * Gene expression * Geranylgeranyl pyrophosphate * HMG-CoA reductase inhibitors * Isoprenoids * K-Ras oncogene * Mevalonate * Pncreatic cancer * Prenylation * Statins Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Cell biology Impact factor: 2.073, year: 2016

  20. Biological Modulation of Upper Ocean Physics: Simulating the Biothermal Feedback Effect in Monterey Bay, California

    Science.gov (United States)

    2014-04-08

    Biological Model The biological model integrated into COAMPS is a four-component nutrient-phytoplankton-detritus ( NPD ) model. Nitrate is initialized...in nitrogen [Kahler and Koeve, 2001], and require additional sets of state variables and parameterizations than those presented within our simple NPD ...cycles, Photosynth. Res., 39, 235–258. Franks, P. J. S., J. S. Wroblewski, and G. R. Flierl (1986), Behavior of a simple plankton model with food -level

  1. Phase microscopy of technical and biological samples through random phase modulation with a difuser

    DEFF Research Database (Denmark)

    Almoro, Percival; Pedrini, Giancarlo; Gundu, Phanindra Narayan

    2010-01-01

    A technique for phase microscopy using a phase diffuser and a reconstruction algorithm is proposed. A magnified specimen wavefront is projected on the diffuser plane that modulates the wavefront into a speckle field. The speckle patterns at axially displaced planes are sampled and used......) 2010 Optical Society of America...

  2. Exploring Cystic Fibrosis Using Bioinformatics Tools: A Module Designed for the Freshman Biology Course

    Science.gov (United States)

    Zhang, Xiaorong

    2011-01-01

    We incorporated a bioinformatics component into the freshman biology course that allows students to explore cystic fibrosis (CF), a common genetic disorder, using bioinformatics tools and skills. Students learn about CF through searching genetic databases, analyzing genetic sequences, and observing the three-dimensional structures of proteins…

  3. Moving Away from Dogmatic Knowledge Dissemination in a Cell Biology Module: Examples from Singapore

    Science.gov (United States)

    Yeong, Foong May

    2012-01-01

    A surge in the amount of information in the discipline of Cell Biology presents a problem to the teaching of undergraduates under time constraints. In most textbooks and during lectures, students in Singapore are often taught in a dogmatic manner where concepts and ideas are expounded to them. The students in turn passively receive the materials…

  4. Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways.

    Science.gov (United States)

    Zhang, Aihua; Yan, Guangli; Sun, Hui; Cheng, Weiping; Meng, Xiangcai; Liu, Li; Xie, Ning; Wang, Xijun

    2016-02-16

    Acupuncture is an alternative therapy that is widely used to treat various diseases. However, detailed biological interpretation of the acupuncture stimulations is limited. We here used metabolomics and proteomics technology, thereby identifying the serum small molecular metabolites into the effect and mechanism pathways of standardized acupuncture treatments at 'Zusanli' acupoint which was the most often used acupoint in previous reports. Comprehensive overview of serum metabolic profiles during acupuncture stimulation was investigated. Thirty-four differential metabolites were identified in serum metabolome and associated with ten metabolism pathways. Importantly, we have found that high impact glycerophospholipid metabolism, fatty acid metabolism, ether lipid metabolism were acutely perturbed by acupuncture stimulation. As such, these alterations may be useful to clarify the biological mechanism of acupuncture stimulation. A series of differentially expressed proteins were identified and such effects of acupuncture stimulation were found to play a role in transport, enzymatic activity, signaling pathway or receptor interaction. Pathway analysis further revealed that most of these proteins were found to play a pivotal role in the regulation of multiple metabolism pathways. It demonstrated that the metabolomics coupled with proteomics as a powerful approach for potential applications in understanding the biological effects of acupuncture stimulation.

  5. Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of Chemotherapeutic Drugs in Breast Cancer Cells

    Directory of Open Access Journals (Sweden)

    Inês L. Martins

    2013-05-01

    Full Text Available We report the development of a new microwave-based synthetic methodology mediated by Woollins’ reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A preliminary evaluation on the modulation of antioxidant activity upon selenation of caffeine, using the DPPH assay, indicated a mild antioxidant activity for 6-selenocaffeine, contrasting with caffeine, that exhibited no antioxidant activity under the same experimental conditions. Interestingly, whereas 6-selenocaffeine has revealed to have a low cytotoxic potential in both MCF10A and MCF-7 breast cells (24 h, up to 100 µM, MTT assay, a differential effect was observed when used in combination with the anticancer agents doxorubicin and oxaliplatin in MCF-7 breast cancer cells. The co-treatment of doxorubicin (1 µM and 6-selenocaffeine (100 µM resulted in a slight decrease in cellular viability when compared to doxorubicin (1 µM alone. Conversely, the seleno-caffeine derivative at the same concentration markedly increased the viability of oxaliplatin (100 µM-treated cells (p < 0.01. Overall, this work highlights an emerging methodology to synthesize organoselenium compounds and points out the differential roles of 6-selenocaffeine in the modulation of the cytotoxicity of anticancer agents.

  6. Significant Modules and Biological Processes between Active Components of Salvia miltiorrhiza Depside Salt and Aspirin

    Directory of Open Access Journals (Sweden)

    Yuan Li

    2016-01-01

    Full Text Available The aim of this study is to examine and compare the similarities and differences between active components of S. miltiorrhiza depside salt and aspirin using perspective of pharmacological molecular networks. Active components of S. miltiorrhiza depside salt and aspirin’s related genes were identified via the STITCH4.0 and GeneCards Database. A text search engine (Agilent Literature Search 2.71 and MCODE software were applied to construct network and divide modules, respectively. Finally, 32, 2, and 28 overlapping genes, modules, and pathways were identified between active components of S. miltiorrhiza depside salt and aspirin. A multidimensional framework of drug network showed that two networks reflected commonly in human aortic endothelial cells and atherosclerosis process. Aspirin plays a more important role in metabolism, such as the well-known AA metabolism pathway and other lipid or carbohydrate metabolism pathways. S. miltiorrhiza depside salt still plays a regulatory role in type II diabetes mellitus, insulin resistance, and adipocytokine signaling pathway. Therefore, this study suggests that aspirin combined with S. miltiorrhiza depside salt may be more efficient in treatment of CHD patients, especially those with diabetes mellitus or hyperlipidemia. Further clinical trials to confirm this hypothesis are still needed.

  7. Physical and biological pretreatment quality assurance of the head and neck cancer plan with the volumetric modulated arc therapy

    Science.gov (United States)

    Park, So-Hyun; Lee, Dong-Soo; Lee, Yun-Hee; Lee, Seu-Ran; Kim, Min-Ju; Suh, Tae-Suk

    2015-09-01

    The aim of this work is to demonstrate both the physical and the biological quality assurance (QA) aspects as pretreatment QA of the head and neck (H&N) cancer plan for the volumetric modulated arc therapy (VMAT). Ten H&N plans were studied. The COMPASS® dosimetry analysis system and the tumor control probability (TCP) and the normal tissue complication probability (NTCP) calculation free program were used as the respective measurement and calculation tools. The reliability of these tools was verified by a benchmark study in accordance with the TG-166 report. For the physical component of QA, the gamma passing rates and the false negative cases between the calculated and the measured data were evaluated. The biological component of QA was performed based on the equivalent uniform dose (EUD), TCP and NTCP values. The evaluation was performed for the planning target volumes (PTVs) and the organs at risks (OARs), including the eyes, the lens, the parotid glands, the esophagus, the spinal cord, and the brainstem. All cases had gamma passing rates above 95% at an acceptance tolerance level with the 3%/3 mm criteria. In addition, the false negative instances were presented for the PTVs and OARs. The gamma passing rates exhibited a weak correlation with false negative cases. For the biological QA, the physical dose errors affect the EUD and the TCP for the PTVs, but no linear correlation existed between them. The EUD and NTCP for the OARs were shown the random differences that could not be attributed to the dose errors from the physical QA. The differences in the EUD and NTCP between the calculated and the measured results were mainly demonstrated for the parotid glands. This study describes the importance and the necessity of improved QA to accompany both the physical and the biological aspects for accurate radiation treatment.

  8. Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment.

    Science.gov (United States)

    Kooijmans, Sander A A; Schiffelers, Raymond M; Zarovni, Natasa; Vago, Riccardo

    2016-09-01

    Exosomes are naturally secreted nanovesicles that have recently aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. These 30-100nm sized vesicles are released from the cells into the extracellular space and ultimately into biofluids in a tightly regulated way. Their molecular composition reflects their cells of origin, may confer specific cell or tissue tropism and underlines their biological activity. Exosomes and other extracellular vesicles (EVs) carry specific sets of proteins, nucleic acids (DNA, mRNA and regulatory RNAs), lipids and metabolites that represent an appealing source of novel noninvasive markers through biofluid biopsies. Exosome-shuttled molecules maintain their biological activity and are capable of modulating and reprogramming recipient cells. This multi-faceted nature of exosomes hold great promise for improving cancer treatment featuring them as novel diagnostic sensors as well as therapeutic effectors and drug delivery vectors. Natural biological activity including the therapeutic payload and targeting behavior of EVs can be tuned via genetic and chemical engineering. In this review we describe the properties that EVs share with conventional synthetic nanoparticles, including size, liposome-like membrane bilayer with customizable surface, and multifunctional capacity. We also highlight unique characteristics of EVs, which possibly allow them to circumvent some limitations of synthetic nanoparticle systems and facilitate clinical translation. The latter are in particular correlated with their innate stability, ability to cross biological barriers, efficiently deliver bioactive cargos or evade immune recognition. Furthermore, we discuss the potential roles for EVs in diagnostics and theranostics, and highlight the challenges that still need to be overcome before EVs can be applied to routine clinical practice. Copyright © 2016

  9. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.

    Science.gov (United States)

    Aikawa, Katsuji; Miyawaki, Toshio; Hitaka, Takenori; Imai, Yumi N; Hara, Takahito; Miyazaki, Junichi; Yamaoka, Masuo; Kusaka, Masami; Kanzaki, Naoyuki; Tasaka, Akihiro; Shiraishi, Mitsuru; Yamamoto, Satoshi

    2015-05-15

    To develop effective drugs for hypogonadism, sarcopenia, and cachexia, we designed, synthesized, and evaluated selective androgen receptor modulators (SARMs) that exhibit not only anabolic effects on organs such as muscles and the central nervous system (CNS) but also neutral or antagonistic effects on the prostate. Based on the information obtained from a docking model with androgen receptor (AR), we modified a hit compound A identified through high-throughput screening. Among the prepared compounds, 1-(4-cyano-1-naphthyl)-2,3-disubstituted pyrrolidine derivatives 17h, 17m, and 17j had highly potent AR agonistic activities in vitro and good tissue selectivity in vivo. These derivatives increased the weight of the levator ani muscle without influencing the prostate and seminal vesicle. In addition, these compounds induced sexual behavior in castrated rats, indicating that the compounds could also act as agonists on the CNS. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. High-contrast FFT acousto-optical tomography of biological tissues with a frequency-chirped modulation of the ultrasound

    Science.gov (United States)

    Forget, Benoit C.; Atlan, Michael; Selb, Juliette; Pottier, Lionel; Ramaz, Francois; Boccara, Albert C.

    2003-06-01

    Although tumors can show important contrast in their optical properties at an early stage of development, they are difficult to image optically due the diffusive nature of biological tissues. Such tumors can also be detected by "classical" ultrasound (US) imaging, but the acoustic constrast is often weak at early stages. Acousto-optical (AO) imaging combines light and ultrasound : light carries the desired information and ultrasound provides the spatial resolution. Based on a previous work made by the group of L.V. Wang, we present AO images obtained with chirped US. This modulation of the US frequency allows to encode a spatial region of the medium in the frequency spectrum of the AO signal. We can then obtain the optical contrast along the US path with improved resolution. The technique was apply to the imaging of buried objects in phantoms and to the vizualization of the "virtual source".

  11. Biology

    Indian Academy of Sciences (India)

    I am particularly happy that the Academy is bringing out this document by Professor M S. Valiathan on Ayurvedic Biology. It is an effort to place before the scientific community, especially that of India, the unique scientific opportunities that arise out of viewing Ayurveda from the perspective of contemporary science, its tools ...

  12. Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles.

    Science.gov (United States)

    Carugo, Dario; Aron, Miles; Sezgin, Erdinc; Bernardino de la Serna, Jorge; Kuimova, Marina K; Eggeling, Christian; Stride, Eleanor

    2017-01-01

    The transfer of material from phospholipid-coated microbubbles to cell membranes has been hypothesized to play a role in ultrasound-mediated drug delivery. In this study, we employed quantitative fluorescence microscopy techniques to investigate this phenomenon in both artificial and biological membrane bilayers in an acoustofluidic system. The results of the present study provide strong evidence for the transfer of material from microbubble coatings into cell membranes. Our results indicate that transfer of phospholipids alters the organization of molecules in cell membranes, specifically the lipid ordering or packing, which is known to be a key determinant of membrane mechanical properties, protein dynamics, and permeability. We further show that polyethylene-glycol, used in many clinical microbubble formulations, also has a major impact on both membrane lipid ordering and the extent of lipid transfer, and that this occurs even in the absence of ultrasound exposure. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Using phosphine ligands with a biological role to modulate reactivity in novel platinum complexes

    Science.gov (United States)

    Echeverri, Marcelo; Alvarez-Valdés, Amparo; Navas, Francisco; Perles, Josefina; Sánchez-Pérez, Isabel; Quiroga, A. G.

    2018-02-01

    Three platinum complexes with cis and trans configuration cis-[Pt(TCEP)2Cl2], cis-[Pt(tmTCEP)2Cl2] and trans-[Pt(TCEP)2Cl2], where TCEP is tris(2-carboxyethyl)phosphine, have been synthesized and fully characterized by usual techniques including single-crystal X-ray diffraction for trans-[Pt(TCEP)2Cl2] and cis-[Pt(tmTCEP)2Cl2]. Here, we also report on an esterification process of TCEP, which takes place in the presence of alcohols, leading to a platinum complex coordinated to an ester tmTCEP (2-methoxycarbonylethyl phosphine) ligand. The stability in solution of the three compounds and their interaction with biological models such as DNA (pBR322 and calf thymus DNA) and proteins (lysozyme and RNase) have also been studied.

  14. Implementation of a Service-learning Module in Medical Microbiology and Cell Biology Classes at an Undergraduate Liberal Arts University.

    Science.gov (United States)

    Larios-Sanz, Maia; Simmons, Alexandra D; Bagnall, Ruth Ann; Rosell, Rosemarie C

    2011-01-01

    Here we discuss the implementation of a service-learning module in two upper-division biology classes, Medical Microbiology and Cell Biology. This exciting hands-on learning experience provided our students with an opportunity to extend their learning of in-class topics to a real-life scenario. Students were required to volunteer their time (a minimum of 10 hours in a semester) at an under-served clinic in Houston, Texas. As they interacted with the personnel at the clinic, they were asked to identify the most prevalent disease (infectious for Medical Microbiology, and cellular-based for Cell) seen at the clinic and, working in groups, come up with educational material in the form of a display or brochure to be distributed to patients. The material was meant to educate patients about the disease in general terms, as well as how to recognize (symptoms), prevent and treat it. Students were required to keep a reflective journal in the form of a blog throughout the semester, and present their final materials to the class orally. Students were surveyed about their opinion of the experience at the end of the semester. The vast majority of student participants felt that the project was a positive experience and that it helped them develop additional skills beyond what they learn in the classroom and understand how lecture topics relate to every day life.

  15. Culturally relevant inquiry-based laboratory module implementations in upper-division genetics and cell biology teaching laboratories.

    Science.gov (United States)

    Siritunga, Dimuth; Montero-Rojas, María; Carrero, Katherine; Toro, Gladys; Vélez, Ana; Carrero-Martínez, Franklin A

    2011-01-01

    Today, more minority students are entering undergraduate programs than ever before, but they earn only 6% of all science or engineering PhDs awarded in the United States. Many studies suggest that hands-on research activities enhance students' interest in pursuing a research career. In this paper, we present a model for the implementation of laboratory research in the undergraduate teaching laboratory using a culturally relevant approach to engage students. Laboratory modules were implemented in upper-division genetics and cell biology courses using cassava as the central theme. Students were asked to bring cassava samples from their respective towns, which allowed them to compare their field-collected samples against known lineages from agricultural stations at the end of the implementation. Assessment of content and learning perceptions revealed that our novel approach allowed students to learn while engaged in characterizing Puerto Rican cassava. In two semesters, based on the percentage of students who answered correctly in the premodule assessment for content knowledge, there was an overall improvement of 66% and 55% at the end in the genetics course and 24% and 15% in the cell biology course. Our proposed pedagogical model enhances students' professional competitiveness by providing students with valuable research skills as they work on a problem to which they can relate.

  16. LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

    Science.gov (United States)

    Loh, Nellie Y; Neville, Matt J; Marinou, Kyriakoula; Hardcastle, Sarah A; Fielding, Barbara A; Duncan, Emma L; McCarthy, Mark I; Tobias, Jonathan H; Gregson, Celia L; Karpe, Fredrik; Christodoulides, Constantinos

    2015-02-03

    Common variants in WNT pathway genes have been associated with bone mass and fat distribution, the latter predicting diabetes and cardiovascular disease risk. Rare mutations in the WNT co-receptors LRP5 and LRP6 are similarly associated with bone and cardiometabolic disorders. We investigated the role of LRP5 in human adipose tissue. Subjects with gain-of-function LRP5 mutations and high bone mass had enhanced lower-body fat accumulation. Reciprocally, a low bone mineral density-associated common LRP5 allele correlated with increased abdominal adiposity. Ex vivo LRP5 expression was higher in abdominal versus gluteal adipocyte progenitors. Equivalent knockdown of LRP5 in both progenitor types dose-dependently impaired β-catenin signaling and led to distinct biological outcomes: diminished gluteal and enhanced abdominal adipogenesis. These data highlight how depot differences in WNT/β-catenin pathway activity modulate human fat distribution via effects on adipocyte progenitor biology. They also identify LRP5 as a potential pharmacologic target for the treatment of cardiometabolic disorders. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  17. Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects

    Directory of Open Access Journals (Sweden)

    David Vauzour

    2012-01-01

    Full Text Available Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. In particular, polyphenols have been reported to exert their neuroprotective actions through the potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning, and cognitive function. Despite significant advances in our understanding of the biology of polyphenols, they are still mistakenly regarded as simply acting as antioxidants. However, recent evidence suggests that their beneficial effects involve decreases in oxidative/inflammatory stress signaling, increases in protective signaling and neurohormetic effects leading to the expression of genes that encode antioxidant enzymes, phase-2 enzymes, neurotrophic factors, and cytoprotective proteins. Specific examples of such pathways include the sirtuin-FoxO pathway, the NF-κB pathway, and the Nrf-2/ARE pathway. Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols have the potential to prevent the progression of neurodegenerative pathologies.

  18. Micro modules for mobile shape, color and spectral imaging with smartpads in industry, biology and medicine

    Science.gov (United States)

    Hofmann, Dietrich; Dittrich, Paul-Gerald; Düntsch, Eric; Kraus, Daniel

    2014-02-01

    Aim of the paper is the demonstration of a paradigm shift in shape, color and spectral measurements in industry, biology and medicine as well as in measurement education and training. Innovative hardware apps (hwapps) and software apps (swapps) with smartpads are fundamental enablers for the transformation from conventional stationary working places towards innovative mobile working places with in-field measurements and point-of-care (POC) diagnostics. Mobile open online courses (MOOCs) are transforming the study habits. Practical examples for the application of innovative photonic micro shapemeters, colormeters and spectrometers will be given. The innovative approach opens so far untapped enormous markets for measurement science, engineering and training. These innovative working conditions will be fast accepted due to their convenience, reliability and affordability. A highly visible advantage of smartpads is the huge number of their distribution, their worldwide connectivity via Internet and cloud services, the standardized interfaces like USB and HDMI and the experienced capabilities of their users for practical operations, learned with their private smartpads.

  19. Cerium oxide nanozyme modulate the ‘exercise’ redox biology of skeletal muscle

    Science.gov (United States)

    Arya, Aditya; Sethy, Niroj Kumar; Gangwar, Anamika; Bhargava, Neelima; Dubey, Amarish; Roy, Manas; Srivastava, Gaurav; Singh, Sushil Kumar; Das, Mainak; Bhargava, Kalpana

    2017-05-01

    ‘Exercise’ is a double-edged sword for the skeletal muscle. Small amount of ROS generated during mild exercise, is essential for normal force generation; whereas large quantity of ROS generated during intense exercise, may cause contractile dysfunction, resulting in muscle weakness and fatigue. One of the key question in skeletal muscle physiology is ‘could antioxidant therapy improve the skeletal muscle endurance? A question, which has resulted in contradictory experimental findings till this date. This work has addressed this ‘very question’ using a synthetic, inorganic, antioxidant nano-material viz., ‘cerium oxide nanozyme’ (CON). It has been introduced in the rat by intramuscular injection, and the skeletal muscle endurance has been evaluated. Intramuscular injections of CON, concurrent with exercise, enhanced muscle mass, glycogen and ATP content, type I fiber ratio, thus resulting in significantly higher muscle endurance. Electron microscope studies confirmed the presence of CON in the vicinity of muscle mitochondria. There was an increase in the number and size of the muscle mitochondria in the CON treated muscle, following exercise, as compared to the untreated group with only exercised muscle. Quantitative proteomics data and subsequent biological network analysis studies, identified higher levels of oxidative phosphorylation, TCA cycle output and glycolysis in CON supplemented exercised muscle over only exercised muscle. This was further associated with significant increase in the mitochondrial respiratory capacity and muscle contraction, primarily due to higher levels of electron transport chain proteins like NDUFA9, SDHA, ATP5B and ATP5D, which were validated by real-time PCR and western blotting. Along with this, persistence of CON in muscle was evaluated with ICP-MS analysis, which revealed clearance of the particles after 90 d, without exhibiting any inflammation or adverse affects on the health of the experimental animals. Thus a

  20. The use of biologically related model (Eclipse for the intensity-modulated radiation therapy planning of nasopharyngeal carcinomas.

    Directory of Open Access Journals (Sweden)

    Monica W K Kan

    Full Text Available Intensity-modulated radiation therapy (IMRT is the most common treatment technique for nasopharyngeal carcinoma (NPC. Physical quantities such as dose/dose-volume parameters are used conventionally for IMRT optimization. The use of biological related models has been proposed and can be a new trend. This work was to assess the performance of the biologically based IMRT optimization model installed in a popular commercial treatment planning system (Eclipse as compared to its dose/dose volume optimization model when employed in the clinical environment for NPC cases.Ten patients of early stage NPC and ten of advanced stage NPC were selected for this study. IMRT plans optimized using biological related approach (BBTP were compared to their corresponding plans optimized using the dose/dose volume based approach (DVTP. Plan evaluation was performed using both biological indices and physical dose indices such as tumor control probability (TCP, normal tissue complication probability (NTCP, target coverage, conformity, dose homogeneity and doses to organs at risk. The comparison results of the more complex advanced stage cases were reported separately from those of the simpler early stage cases.The target coverage and conformity were comparable between the two approaches, with BBTP plans producing more hot spots. For the primary targets, BBTP plans produced comparable TCP for the early stage cases and higher TCP for the advanced stage cases. BBTP plans reduced the volume of parotid glands receiving doses of above 40 Gy compared to DVTP plans. The NTCP of parotid glands produced by BBTP were 8.0 ± 5.8 and 7.9 ± 8.7 for early and advanced stage cases, respectively, while those of DVTP were 21.3 ± 8.3 and 24.4 ± 12.8, respectively. There were no significant differences in the NTCP values between the two approaches for the serial organs.Our results showed that the BBTP approach could be a potential alternative approach to the DVTP approach for NPC.

  1. Implementation of a Service-Learning Module in Medical Microbiology and Cell Biology Classes at an Undergraduate Liberal Arts University

    Directory of Open Access Journals (Sweden)

    Maia Larios-Sanz

    2011-03-01

    Full Text Available Here we discuss the implementation of a service-learning module in two upper-division biology classes, Medical Microbiology and Cell Biology. This exciting hands-on learning experience provided our students with an opportunity to extend their learning of in-class topics to a real-life scenario. Students were required to volunteer their time (a minimum of 10 hours in a semester at an under-served clinic in Houston, Texas. As they interacted with the personnel at the clinic, they were asked to identify the most prevalent disease (infectious for Medical Microbiology, and cellular-based for Cell seen at the clinic and, working in groups, come up with educational material in the form of a display or brochure to be distributed to patients. The material was meant to educate patients about the disease in general terms, as well as how to recognize (symptoms, prevent and treat it. Students were required to keep a reflective journal in the form of a blog throughout the semester, and present their final materials to the class orally. Students were surveyed about their opinion of the experience at the end of the semester. The vast majority of student participants felt that the project was a positive experience and that it helped them develop additional skills beyond what they learn in the classroom and understand how lecture topics relate to every day life. Here we discuss the implementation of a service-learning module in two upper division biology classes, Medical Microbiology and Cell Biology. This exciting hands-on learning experience provided our students with an opportunity to extend their learning of in-class topics into a real life scenario. Students were required to volunteer their time (a minimum of 10 hours in a semester at an under-served clinic in Houston, Texas. As they interacted with the personnel at the clinic, they were asked to identify the most prevalent disease (infectious for Medical Microbiology, and cellular-based for Cell seen at the

  2. Biologically Inspired Radiation-Reflecting Ablator (BIRRA) for Enabling Entry Descent and Landing Missions to Gas Giant Planets or Radiation-Intensive Environments

    Data.gov (United States)

    National Aeronautics and Space Administration — We propose to develop and demonstrate a radiationreflecting thermal protection system (TPS) to enable missions where radiative heating during atmospheric entry is...

  3. Convex reformulation of biologically-based multi-criteria intensity-modulated radiation therapy optimization including fractionation effects.

    Science.gov (United States)

    Hoffmann, Aswin L; den Hertog, Dick; Siem, Alex Y D; Kaanders, Johannes H A M; Huizenga, Henk

    2008-11-21

    Finding fluence maps for intensity-modulated radiation therapy (IMRT) can be formulated as a multi-criteria optimization problem for which Pareto optimal treatment plans exist. To account for the dose-per-fraction effect of fractionated IMRT, it is desirable to exploit radiobiological treatment plan evaluation criteria based on the linear-quadratic (LQ) cell survival model as a means to balance the radiation benefits and risks in terms of biologic response. Unfortunately, the LQ-model-based radiobiological criteria are nonconvex functions, which make the optimization problem hard to solve. We apply the framework proposed by Romeijn et al (2004 Phys. Med. Biol. 49 1991-2013) to find transformations of LQ-model-based radiobiological functions and establish conditions under which transformed functions result in equivalent convex criteria that do not change the set of Pareto optimal treatment plans. The functions analysed are: the LQ-Poisson-based model for tumour control probability (TCP) with and without inter-patient heterogeneity in radiation sensitivity, the LQ-Poisson-based relative seriality s-model for normal tissue complication probability (NTCP), the equivalent uniform dose (EUD) under the LQ-Poisson model and the fractionation-corrected Probit-based model for NTCP according to Lyman, Kutcher and Burman. These functions differ from those analysed before in that they cannot be decomposed into elementary EUD or generalized-EUD functions. In addition, we show that applying increasing and concave transformations to the convexified functions is beneficial for the piecewise approximation of the Pareto efficient frontier.

  4. Co-expression module analysis reveals biological processes, genomic gain, and regulatory mechanisms associated with breast cancer progression

    Directory of Open Access Journals (Sweden)

    Derow Catherine K

    2010-05-01

    Full Text Available Abstract Background Gene expression signatures are typically identified by correlating gene expression patterns to a disease phenotype of interest. However, individual gene-based signatures usually suffer from low reproducibility and interpretability. Results We have developed a novel algorithm Iterative Clique Enumeration (ICE for identifying relatively independent maximal cliques as co-expression modules and a module-based approach to the analysis of gene expression data. Applying this approach on a public breast cancer dataset identified 19 modules whose expression levels were significantly correlated with tumor grade. The correlations were reproducible for 17 modules in an independent breast cancer dataset, and the reproducibility was considerably higher than that based on individual genes or modules identified by other algorithms. Sixteen out of the 17 modules showed significant enrichment in certain Gene Ontology (GO categories. Specifically, modules related to cell proliferation and immune response were up-regulated in high-grade tumors while those related to cell adhesion was down-regulated. Further analyses showed that transcription factors NYFB, E2F1/E2F3, NRF1, and ELK1 were responsible for the up-regulation of the cell proliferation modules. IRF family and ETS family proteins were responsible for the up-regulation of the immune response modules. Moreover, inhibition of the PPARA signaling pathway may also play an important role in tumor progression. The module without GO enrichment was found to be associated with a potential genomic gain in 8q21-23 in high-grade tumors. The 17-module signature of breast tumor progression clustered patients into subgroups with significantly different relapse-free survival times. Namely, patients with lower cell proliferation and higher cell adhesion levels had significantly lower risk of recurrence, both for all patients (p = 0.004 and for those with grade 2 tumors (p = 0.017. Conclusions The ICE

  5. The effect of fasting during Ramadan on parameters of the haematological and steroidal modules of the athletes biological passport - a pilot study.

    Science.gov (United States)

    Alsaadi, K; Voss, S C; Kraiem, S; Alwahaibi, A; Alyazedi, S; Dbes, N; Goebel, R; Mohamed-Ali, V; Alsowaidi, S; Seyam, A M; Bashraheel, A S; Alsayrafi, M; Georgakopoulos, C

    2015-01-01

    This study investigated the effect of Ramadan on the haematological and steroid module of the Athletes Biological Passport (ABP) of the World Anti-Doping Agency (WADA). Nine healthy physically active subjects were tested in the morning and afternoon for two days before and three days during Ramadan. Sample collection and all analyses were performed according to WADA technical documents. Although there were significant changes in the haemoglobin concentration during Ramadan, especially during the first fasting week, none of the subjects in this study exceeded the individually calculated thresholds of the ABP. No significant effects on testosterone/epitestosterone (T/E) ratio were observed but only the afternoon specific gravity (SG) of the urine was elevated. Thus, when urinary steroid concentrations are required, SG corrections need to be performed. The haematological and the steroid module of the ABP can be reliably applied during Ramadan as the observed changes are only marginal. Copyright © 2015 John Wiley & Sons, Ltd.

  6. Modulation analysis in spatial phase shifting electronic speckle pattern interferometry and application for automated data selection on biological specimens

    Science.gov (United States)

    Knoche, Sabine; Kemper, Björn; Wernicke, Günther; von Bally, Gert

    2007-02-01

    In electronic speckle pattern interferometry (ESPI), for a fast and objective analysis of measurement data which occur with a high repetition rate, an automated data processing is of particular advantage. For this reason, investigations were carried out to determine if the modulation of speckle interferograms can be applied as a quality parameter for the selection of suitable interferogram data for further evaluation e.g. phase unwrapping when spatial phase shifting (SPS) is performed. Six methods for determining the modulation of speckle interferograms are characterised and compared. The applicability of the speckle interferogram modulation as a parameter for mask generation in the unwrapping process of the phase difference is demonstrated by the evaluation of measurement data obtained from experiments with a spatial phase shifting endoscopic ESPI system on a technical surface and on a human gastrectomy specimen.

  7. Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators

    DEFF Research Database (Denmark)

    Stacy, Danielle M.; Le Quement, Sebastian T.; Hansen, Casper L.

    2013-01-01

    . These compounds were evaluated for their ability to activate or inhibit two QS receptors from two prevalent pathogens – LasR from Pseudomonas aeruginosa and AbaR from Acinetobacter baumannii – using bacterial reporter strains. Several triazole derivatives were identified that were capable of strongly modulating...

  8. [Interior] Configuration options, habitability and architectural aspects of the transfer habitat module (THM) and the surface habitat on Mars (SHM)/ESA's AURORA human mission to Mars (HMM) study

    Science.gov (United States)

    Imhof, Barbara

    2007-02-01

    This paper discusses the findings for [Interior] configuration options, habitability and architectural aspects of a first human spacecraft to Mars. In 2003 the space architecture office LIQUIFER was invited by the European Space Agency's (ESA) AURORA Program committee to consult the scientists and engineers from the European Space and Technology Center (ESTEC) and other European industrial communities with developing the first human mission to Mars, which will take place in 2030, regarding the architectural issues of crewed habitats. The task was to develop an interior configuration for a transfer vehicle (TV) to Mars, especially a transfer habitation module (THM) and a surface habitat module (SHM) on Mars. The total travel time Earth—Mars and back for a crew of six amounts to approximately 900 days. After a 200-day-flight three crewmembers will land on Mars in the Mars excursion vehicle (MEV) and will live and work in the SHM for 30 days. For 500 days before the 200-day journey back the spacecraft continues to circle the Martian orbit for further exploration. The entire mission program is based on our present knowledge of technology. The project was compiled during a constant feedback-design process and trans-disciplinary collaboration sessions in the ESA-ESTEC concurrent design facility. Long-term human space flight sets new spatial conditions and requirements to the design concept. The guidelines were developed from relevant numbers and facts of recognized standards, interviews with astronauts/cosmonauts and from analyses about habitability, sociology, psychology and configuration concepts of earlier space stations in combination with the topics of the individual's perception and relation of space. Result of this study is the development of a prototype concept for the THM and SHM with detailed information and complete plans of the interior configuration, including mass calculations. In addition the study contains a detailed explanation of the development of

  9. STS-70 mission highlights

    Science.gov (United States)

    1995-09-01

    The highlights of the STS-70 mission are presented in this video. The flight crew consisted of Cmdr. John Hendricks, Pilot Kevin Kregel, Flight Engineer Nancy Curie, and Mission Specialists Dr. Don Thomas and Dr. Mary Ellen Weber. The mission's primary objective was the deployment of the 7th Tracking Data and Relay Satellite (TDRS), which will provide a communication, tracking, telemetry, data acquisition, and command services space-based network system essential to low Earth orbital spacecraft. Secondary mission objectives included activating and studying the Physiological and Anatomical Rodent Experiment/National Institutes of Health-Rodents (PARE/NIH-R), The Bioreactor Demonstration System (BDS), the Commercial Protein Crystal Growth (CPCG) studies, the Space Tissue Loss/National Institutes of Health-Cells (STL/NIH-C) experiment, the Biological Research in Canisters (BRIC) experiment, Shuttle Amateur Radio Experiment-2 (SAREX-2), the Visual Function Tester-4 (VFT-4), the Hand-Held, Earth Oriented, Real-Time, Cooperative, User-Friendly, Location-Targeting and Environmental System (HERCULES), the Microcapsules in Space-B (MIS-B) experiment, the Windows Experiment (WINDEX), the Radiation Monitoring Equipment-3 (RME-3), and the Military Applications of Ship Tracks (MAST) experiment. There was an in-orbit dedication ceremony by the spacecrew and the newly Integrated Mission Control Center to commemorate the Center's integration. The STS-70 mission was the first mission monitored by this new control center. Earth views included the Earth's atmosphere, a sunrise over the Earth's horizon, several views of various land masses, some B/W lightning shots, some cloud cover, and a tropical storm.

  10. Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs).

    Science.gov (United States)

    Mitchell, Helen J; Dankulich, William P; Hartman, George D; Prueksaritanont, Thomayant; Schmidt, Azriel; Vogel, Robert L; Bai, Chang; McElwee-Witmer, Sheila; Zhang, Hai Z; Chen, Fang; Leu, Chih-Tai; Kimmel, Donald B; Ray, William J; Nantermet, Pascale; Gentile, Michael A; Duggan, Mark E; Meissner, Robert S

    2009-08-13

    A novel series of 16-substituted-4-azasteroids has been identified as potential tissue-selective androgen receptor modulators. These ligands display potent hAR binding and agonist activity, low virilizing potential, and good pharmacokinetic profiles in dogs. On the basis of its in vitro profile, 21 was evaluated in the OVX and ORX rat models and exhibited an osteoanabolic, tissue-selective profile.

  11. Apollo 11 Mission Commemorated

    Science.gov (United States)

    Showstack, Randy

    2009-07-01

    On 24 July 1969, 4 days after Apollo 11 Mission Commander Neil Armstrong and Lunar Module Eagle Pilot Eugene “Buzz” Aldrin had become the first people to walk on the Moon, they and Apollo 11 Command Module Pilot Michael Collins peered through a window of the Mobile Quarantine Facility on board the U.S.S. Hornet following splashdown of the command module in the central Pacific as U.S. President Richard Nixon told them, “This is the greatest week in the history of the world since the creation.” Forty years later, the Apollo 11 crew and other Apollo-era astronauts gathered at several events in Washington, D. C., to commemorate and reflect on the Apollo program, that mission, and the future of manned spaceflight. “I don’t know what the greatest week in history is,” Aldrin told Eos. “But it was certainly a pioneering opening the door. With the door open when we touched down on the Moon, that was what enabled humans to put many more footprints on the surface of the Moon.”

  12. Low Fidelity Imitation of Atypical Biological Kinematics in Autism Spectrum Disorders Is Modulated by Self-Generated Selective Attention

    Science.gov (United States)

    Hayes, Spencer J.; Andrew, Matthew; Elliott, Digby; Gowen, Emma; Bennett, Simon J.

    2016-01-01

    We examined whether adults with autism had difficulty imitating atypical biological kinematics. To reduce the impact that higher-order processes have on imitation we used a non-human agent model to control social attention, and removed end-state target goals in half of the trials to minimise goal-directed attention. Findings showed that only…

  13. Spacelab 3 mission

    Science.gov (United States)

    Dalton, Bonnie P.

    1990-01-01

    Spacelab-3 (SL-3) was the first microgravity mission of extended duration involving crew interaction with animal experiments. This interaction involved sharing the Spacelab environmental system, changing animal food, and changing animal waste trays by the crew. Extensive microbial testing was conducted on the animal specimens and crew and on their ground and flight facilities during all phases of the mission to determine the potential for cross contamination. Macroparticulate sampling was attempted but was unsuccessful due to the unforseen particulate contamination occurring during the flight. Particulate debris of varying size (250 micron to several inches) and composition was recovered post flight from the Spacelab floor, end cones, overhead areas, avionics fan filter, cabin fan filters, tunnel adaptor, and from the crew module. These data are discussed along with solutions, which were implemented, for particulate and microbial containment for future flight facilities.

  14. Novel aquatic modules for bioregenerative life-support systems based on the closed equilibrated biological aquatic system (c.e.b.a.s.)

    Science.gov (United States)

    Bluem, Volker; Paris, Frank

    2002-06-01

    The closed equilibrated biological aquatic system (C.E.B.A.S) is a man-made aquatic ecosystem which consists of four subcomponents: an aquatic animal habitat, an aquatic plant bioreactor, an ammonia oxidizing bacteria filter and a data acquisition/control unit. It is a precursor for different types of fish and aquatic plant production sites which are disposed for the integration into bioregenerative life-support systems. The results of two successful spaceflights of a miniaturized C.E.B.A.S version (the C.E.B.A.S. MINI MODULE) allow the optimization of aquatic food production systems which are already developed in the ground laboratory and open new aspects for their utilization as aquatic modules in space bioregenerative life support systems. The total disposition offers different stages of complexity of such aquatic modules starting with simple but efficient aquatic plant cultivators which can be implemented into water recycling systems and ending up in combined plant/fish aquaculture in connection with reproduction modules and hydroponics applications for higher land plants. In principle, aquaculture of fishes and/or other aquatic animals edible for humans offers optimal animal protein production under lowered gravity conditions without the tremendous waste management problems connected with tetrapod breeding and maintenance. The paper presents details of conducted experimental work and of future dispositions which demonstrate clearly that aquaculture is an additional possibility to combine efficient and simple food production in space with water recycling utilizing safe and performable biotechnologies. Moreover, it explains how these systems may contribute to more variable diets to fulfill the needs of multicultural crews.

  15. Titan Orbiter Aerorover Mission

    Science.gov (United States)

    Sittler Jr., E. C.; Acuna, M.; Burchell, M. J.; Coates, A.; Farrell, W.; Flasar, M.; Goldstein, B. E.; Gorevan, S.; Hartle, R. E.; Johnson, W. T. K.

    2001-01-01

    We propose a combined Titan orbiter and Titan Aerorover mission with an emphasis on both in situ and remote sensing measurements of Titan's surface, atmosphere, ionosphere, and magnetospheric interaction. The biological aspect of the Titan environment will be emphasized by the mission (i.e., search for organic materials which may include simple organics to 'amono' analogues of amino acids and possibly more complex, lightening detection and infrared, ultraviolet, and charged particle interactions with Titan's surface and atmosphere). An international mission is assumed to control costs. NASA will provide the orbiter, launch vehicle, DSN coverage and operations, while international partners will provide the Aerorover and up to 30% of the cost for the scientific instruments through collaborative efforts. To further reduce costs we propose a single PI for orbiter science instruments and a single PI for Aerorover science instruments. This approach will provide single command/data and power interface between spacecraft and orbiter instruments that will have redundant central DPU and power converter for their instruments. A similar approach could be used for the Aerorover. The mission profile will be constructed to minimize conflicts between Aerorover science, orbiter radar science, orbiter radio science, orbiter imaging science, and orbiter fields and particles (FP) science. Additional information is contained in the original extended abstract.

  16. Thermal expansion of the cryoprotectant cocktail DP6 combined with synthetic ice modulators in presence and absence of biological tissues.

    Science.gov (United States)

    Eisenberg, David P; Taylor, Michael J; Rabin, Yoed

    2012-10-01

    This study explores physical effects associated with the application of cryopreservation via vitrification using a class of compounds which are defined here as synthetic ice modulators (SIMs). The general classification of SIMs includes molecules that modulate ice nucleation and growth, or possess properties of stabilizing the amorphous state, by virtue of their chemical structure and at concentrations that are not explained on a purely colligative basis. A sub-category of SIMs, referred to in the literature as synthetic ice blockers (SIBs), are compounds that interact directly with ice nuclei or crystals to modify their structure and/or rate of growth. The current study is part of an ongoing effort to characterize thermo-mechanical effects during vitrification, with emphasis on measuring the physical property of thermal expansion-the driving mechanism to thermo-mechanical stress. Materials under investigation are the cryoprotective agent (CPA) cocktail DP6 in combination with one of the following SIMs: 12% polyethylene glycol 400, 6% 1,3 cyclohexanediol, and 6% 2,3 butanediol. Results are presented for the CPA-SIM cocktail in the absence and presence of bovine muscle and goat artery specimens. This study focuses on the upper part of the cryogenic temperature range, where the CPA behaves as a fluid for all practical applications. Results of this study indicate that the addition of SIMs to DP6 allows lower cooling rates to ensure vitrification and extends the range of measurements. It is demonstrated that the combination of SIM with DP6 increases the thermal expansion of the cocktail, with implications for the likelihood of fracture formation-the most dramatic outcome of thermo-mechanical stress. Copyright © 2012 Elsevier Inc. All rights reserved.

  17. Dissection of Biological Property of Chinese Acupuncture Point Zusanli Based on Long-Term Treatment via Modulating Multiple Metabolic Pathways

    Directory of Open Access Journals (Sweden)

    Guangli Yan

    2013-01-01

    Full Text Available Acupuncture has a history of over 3000 years and is a traditional Chinese medical therapy that uses hair-thin metal needles to puncture the skin at specific points on the body to promote wellbeing, while its molecular mechanism and ideal biological pathways are still not clear. High-throughput metabolomics is the global assessment of endogenous metabolites within a biologic system and can potentially provide a more accurate snap shot of the actual physiological state. We hypothesize that acupuncture-treated human would produce unique characterization of metabolic phenotypes. In this study, UPLC/ESI-HDMS coupled with pattern recognition methods and system analysis were carried out to investigate the mechanism and metabolite biomarkers for acupuncture treatment at “Zusanli” acupoint (ST-36 as a case study. The top 5 canonical pathways including alpha-linolenic acid metabolism, d-glutamine and d-glutamate metabolism, citrate cycle, alanine, aspartate, and glutamate metabolism, and vitamin B6 metabolism pathways were acutely perturbed, and 53 differential metabolites were identified by chemical profiling and may be useful to clarify the physiological basis and mechanism of ST-36. More importantly, network construction has led to the integration of metabolites associated with the multiple perturbation pathways. Urine metabolic profiling might be a promising method to investigate the molecular mechanism of acupuncture.

  18. Cosmetics as a feature of the extended human phenotype: modulation of the perception of biologically important facial signals.

    Science.gov (United States)

    Etcoff, Nancy L; Stock, Shannon; Haley, Lauren E; Vickery, Sarah A; House, David M

    2011-01-01

    Research on the perception of faces has focused on the size, shape, and configuration of inherited features or the biological phenotype, and largely ignored the effects of adornment, or the extended phenotype. Research on the evolution of signaling has shown that animals frequently alter visual features, including color cues, to attract, intimidate or protect themselves from conspecifics. Humans engage in conscious manipulation of visual signals using cultural tools in real time rather than genetic changes over evolutionary time. Here, we investigate one tool, the use of color cosmetics. In two studies, we asked viewers to rate the same female faces with or without color cosmetics, and we varied the style of makeup from minimal (natural), to moderate (professional), to dramatic (glamorous). Each look provided increasing luminance contrast between the facial features and surrounding skin. Faces were shown for 250 ms or for unlimited inspection time, and subjects rated them for attractiveness, competence, likeability and trustworthiness. At 250 ms, cosmetics had significant positive effects on all outcomes. Length of inspection time did not change the effect for competence or attractiveness. However, with longer inspection time, the effect of cosmetics on likability and trust varied by specific makeup looks, indicating that cosmetics could impact automatic and deliberative judgments differently. The results suggest that cosmetics can create supernormal facial stimuli, and that one way they may do so is by exaggerating cues to sexual dimorphism. Our results provide evidence that judgments of facial trustworthiness and attractiveness are at least partially separable, that beauty has a significant positive effect on judgment of competence, a universal dimension of social cognition, but has a more nuanced effect on the other universal dimension of social warmth, and that the extended phenotype significantly influences perception of biologically important signals at first

  19. Cosmetics as a feature of the extended human phenotype: modulation of the perception of biologically important facial signals.

    Directory of Open Access Journals (Sweden)

    Nancy L Etcoff

    Full Text Available Research on the perception of faces has focused on the size, shape, and configuration of inherited features or the biological phenotype, and largely ignored the effects of adornment, or the extended phenotype. Research on the evolution of signaling has shown that animals frequently alter visual features, including color cues, to attract, intimidate or protect themselves from conspecifics. Humans engage in conscious manipulation of visual signals using cultural tools in real time rather than genetic changes over evolutionary time. Here, we investigate one tool, the use of color cosmetics. In two studies, we asked viewers to rate the same female faces with or without color cosmetics, and we varied the style of makeup from minimal (natural, to moderate (professional, to dramatic (glamorous. Each look provided increasing luminance contrast between the facial features and surrounding skin. Faces were shown for 250 ms or for unlimited inspection time, and subjects rated them for attractiveness, competence, likeability and trustworthiness. At 250 ms, cosmetics had significant positive effects on all outcomes. Length of inspection time did not change the effect for competence or attractiveness. However, with longer inspection time, the effect of cosmetics on likability and trust varied by specific makeup looks, indicating that cosmetics could impact automatic and deliberative judgments differently. The results suggest that cosmetics can create supernormal facial stimuli, and that one way they may do so is by exaggerating cues to sexual dimorphism. Our results provide evidence that judgments of facial trustworthiness and attractiveness are at least partially separable, that beauty has a significant positive effect on judgment of competence, a universal dimension of social cognition, but has a more nuanced effect on the other universal dimension of social warmth, and that the extended phenotype significantly influences perception of biologically important

  20. Cosmetics as a Feature of the Extended Human Phenotype: Modulation of the Perception of Biologically Important Facial Signals

    Science.gov (United States)

    Etcoff, Nancy L.; Stock, Shannon; Haley, Lauren E.; Vickery, Sarah A.; House, David M.

    2011-01-01

    Research on the perception of faces has focused on the size, shape, and configuration of inherited features or the biological phenotype, and largely ignored the effects of adornment, or the extended phenotype. Research on the evolution of signaling has shown that animals frequently alter visual features, including color cues, to attract, intimidate or protect themselves from conspecifics. Humans engage in conscious manipulation of visual signals using cultural tools in real time rather than genetic changes over evolutionary time. Here, we investigate one tool, the use of color cosmetics. In two studies, we asked viewers to rate the same female faces with or without color cosmetics, and we varied the style of makeup from minimal (natural), to moderate (professional), to dramatic (glamorous). Each look provided increasing luminance contrast between the facial features and surrounding skin. Faces were shown for 250 ms or for unlimited inspection time, and subjects rated them for attractiveness, competence, likeability and trustworthiness. At 250 ms, cosmetics had significant positive effects on all outcomes. Length of inspection time did not change the effect for competence or attractiveness. However, with longer inspection time, the effect of cosmetics on likability and trust varied by specific makeup looks, indicating that cosmetics could impact automatic and deliberative judgments differently. The results suggest that cosmetics can create supernormal facial stimuli, and that one way they may do so is by exaggerating cues to sexual dimorphism. Our results provide evidence that judgments of facial trustworthiness and attractiveness are at least partially separable, that beauty has a significant positive effect on judgment of competence, a universal dimension of social cognition, but has a more nuanced effect on the other universal dimension of social warmth, and that the extended phenotype significantly influences perception of biologically important signals at first

  1. The Gaia mission

    Science.gov (United States)

    Gaia Collaboration; Prusti, T.; de Bruijne, J. H. J.; Brown, A. G. A.; Vallenari, A.; Babusiaux, C.; Bailer-Jones, C. A. L.; Bastian, U.; Biermann, M.; Evans, D. W.; Eyer, L.; Jansen, F.; Jordi, C.; Klioner, S. A.; Lammers, U.; Lindegren, L.; Luri, X.; Mignard, F.; Milligan, D. J.; Panem, C.; Poinsignon, V.; Pourbaix, D.; Randich, S.; Sarri, G.; Sartoretti, P.; Siddiqui, H. I.; Soubiran, C.; Valette, V.; van Leeuwen, F.; Walton, N. A.; Aerts, C.; Arenou, F.; Cropper, M.; Drimmel, R.; Høg, E.; Katz, D.; Lattanzi, M. G.; O'Mullane, W.; Grebel, E. K.; Holland, A. D.; Huc, C.; Passot, X.; Bramante, L.; Cacciari, C.; Castañeda, J.; Chaoul, L.; Cheek, N.; De Angeli, F.; Fabricius, C.; Guerra, R.; Hernández, J.; Jean-Antoine-Piccolo, A.; Masana, E.; Messineo, R.; Mowlavi, N.; Nienartowicz, K.; Ordóñez-Blanco, D.; Panuzzo, P.; Portell, J.; Richards, P. J.; Riello, M.; Seabroke, G. M.; Tanga, P.; Thévenin, F.; Torra, J.; Els, S. G.; Gracia-Abril, G.; Comoretto, G.; Garcia-Reinaldos, M.; Lock, T.; Mercier, E.; Altmann, M.; Andrae, R.; Astraatmadja, T. L.; Bellas-Velidis, I.; Benson, K.; Berthier, J.; Blomme, R.; Busso, G.; Carry, B.; Cellino, A.; Clementini, G.; Cowell, S.; Creevey, O.; Cuypers, J.; Davidson, M.; De Ridder, J.; de Torres, A.; Delchambre, L.; Dell'Oro, A.; Ducourant, C.; Frémat, Y.; García-Torres, M.; Gosset, E.; Halbwachs, J.-L.; Hambly, N. C.; Harrison, D. L.; Hauser, M.; Hestroffer, D.; Hodgkin, S. T.; Huckle, H. E.; Hutton, A.; Jasniewicz, G.; Jordan, S.; Kontizas, M.; Korn, A. J.; Lanzafame, A. C.; Manteiga, M.; Moitinho, A.; Muinonen, K.; Osinde, J.; Pancino, E.; Pauwels, T.; Petit, J.-M.; Recio-Blanco, A.; Robin, A. C.; Sarro, L. M.; Siopis, C.; Smith, M.; Smith, K. W.; Sozzetti, A.; Thuillot, W.; van Reeven, W.; Viala, Y.; Abbas, U.; Abreu Aramburu, A.; Accart, S.; Aguado, J. J.; Allan, P. M.; Allasia, W.; Altavilla, G.; Álvarez, M. A.; Alves, J.; Anderson, R. I.; Andrei, A. H.; Anglada Varela, E.; Antiche, E.; Antoja, T.; Antón, S.; Arcay, B.; Atzei, A.; Ayache, L.; Bach, N.; Baker, S. G.; Balaguer-Núñez, L.; Barache, C.; Barata, C.; Barbier, A.; Barblan, F.; Baroni, M.; Barrado y Navascués, D.; Barros, M.; Barstow, M. A.; Becciani, U.; Bellazzini, M.; Bellei, G.; Bello García, A.; Belokurov, V.; Bendjoya, P.; Berihuete, A.; Bianchi, L.; Bienaymé, O.; Billebaud, F.; Blagorodnova, N.; Blanco-Cuaresma, S.; Boch, T.; Bombrun, A.; Borrachero, R.; Bouquillon, S.; Bourda, G.; Bouy, H.; Bragaglia, A.; Breddels, M. A.; Brouillet, N.; Brüsemeister, T.; Bucciarelli, B.; Budnik, F.; Burgess, P.; Burgon, R.; Burlacu, A.; Busonero, D.; Buzzi, R.; Caffau, E.; Cambras, J.; Campbell, H.; Cancelliere, R.; Cantat-Gaudin, T.; Carlucci, T.; Carrasco, J. M.; Castellani, M.; Charlot, P.; Charnas, J.; Charvet, P.; Chassat, F.; Chiavassa, A.; Clotet, M.; Cocozza, G.; Collins, R. S.; Collins, P.; Costigan, G.; Crifo, F.; Cross, N. J. G.; Crosta, M.; Crowley, C.; Dafonte, C.; Damerdji, Y.; Dapergolas, A.; David, P.; David, M.; De Cat, P.; de Felice, F.; de Laverny, P.; De Luise, F.; De March, R.; de Martino, D.; de Souza, R.; Debosscher, J.; del Pozo, E.; Delbo, M.; Delgado, A.; Delgado, H. E.; di Marco, F.; Di Matteo, P.; Diakite, S.; Distefano, E.; Dolding, C.; Dos Anjos, S.; Drazinos, P.; Durán, J.; Dzigan, Y.; Ecale, E.; Edvardsson, B.; Enke, H.; Erdmann, M.; Escolar, D.; Espina, M.; Evans, N. W.; Eynard Bontemps, G.; Fabre, C.; Fabrizio, M.; Faigler, S.; Falcão, A. J.; Farràs Casas, M.; Faye, F.; Federici, L.; Fedorets, G.; Fernández-Hernández, J.; Fernique, P.; Fienga, A.; Figueras, F.; Filippi, F.; Findeisen, K.; Fonti, A.; Fouesneau, M.; Fraile, E.; Fraser, M.; Fuchs, J.; Furnell, R.; Gai, M.; Galleti, S.; Galluccio, L.; Garabato, D.; García-Sedano, F.; Garé, P.; Garofalo, A.; Garralda, N.; Gavras, P.; Gerssen, J.; Geyer, R.; Gilmore, G.; Girona, S.; Giuffrida, G.; Gomes, M.; González-Marcos, A.; González-Núñez, J.; González-Vidal, J. J.; Granvik, M.; Guerrier, A.; Guillout, P.; Guiraud, J.; Gúrpide, A.; Gutiérrez-Sánchez, R.; Guy, L. P.; Haigron, R.; Hatzidimitriou, D.; Haywood, M.; Heiter, U.; Helmi, A.; Hobbs, D.; Hofmann, W.; Holl, B.; Holland, G.; Hunt, J. A. S.; Hypki, A.; Icardi, V.; Irwin, M.; Jevardat de Fombelle, G.; Jofré, P.; Jonker, P. G.; Jorissen, A.; Julbe, F.; Karampelas, A.; Kochoska, A.; Kohley, R.; Kolenberg, K.; Kontizas, E.; Koposov, S. E.; Kordopatis, G.; Koubsky, P.; Kowalczyk, A.; Krone-Martins, A.; Kudryashova, M.; Kull, I.; Bachchan, R. K.; Lacoste-Seris, F.; Lanza, A. F.; Lavigne, J.-B.; Le Poncin-Lafitte, C.; Lebreton, Y.; Lebzelter, T.; Leccia, S.; Leclerc, N.; Lecoeur-Taibi, I.; Lemaitre, V.; Lenhardt, H.; Leroux, F.; Liao, S.; Licata, E.; Lindstrøm, H. E. P.; Lister, T. A.; Livanou, E.; Lobel, A.; Löffler, W.; López, M.; Lopez-Lozano, A.; Lorenz, D.; Loureiro, T.; MacDonald, I.; Magalhães Fernandes, T.; Managau, S.; Mann, R. G.; Mantelet, G.; Marchal, O.; Marchant, J. M.; Marconi, M.; Marie, J.; Marinoni, S.; Marrese, P. M.; Marschalkó, G.; Marshall, D. J.; Martín-Fleitas, J. M.; Martino, M.; Mary, N.; Matijevič, G.; Mazeh, T.; McMillan, P. J.; Messina, S.; Mestre, A.; Michalik, D.; Millar, N. R.; Miranda, B. M. H.; Molina, D.; Molinaro, R.; Molinaro, M.; Molnár, L.; Moniez, M.; Montegriffo, P.; Monteiro, D.; Mor, R.; Mora, A.; Morbidelli, R.; Morel, T.; Morgenthaler, S.; Morley, T.; Morris, D.; Mulone, A. F.; Muraveva, T.; Musella, I.; Narbonne, J.; Nelemans, G.; Nicastro, L.; Noval, L.; Ordénovic, C.; Ordieres-Meré, J.; Osborne, P.; Pagani, C.; Pagano, I.; Pailler, F.; Palacin, H.; Palaversa, L.; Parsons, P.; Paulsen, T.; Pecoraro, M.; Pedrosa, R.; Pentikäinen, H.; Pereira, J.; Pichon, B.; Piersimoni, A. M.; Pineau, F.-X.; Plachy, E.; Plum, G.; Poujoulet, E.; Prša, A.; Pulone, L.; Ragaini, S.; Rago, S.; Rambaux, N.; Ramos-Lerate, M.; Ranalli, P.; Rauw, G.; Read, A.; Regibo, S.; Renk, F.; Reylé, C.; Ribeiro, R. A.; Rimoldini, L.; Ripepi, V.; Riva, A.; Rixon, G.; Roelens, M.; Romero-Gómez, M.; Rowell, N.; Royer, F.; Rudolph, A.; Ruiz-Dern, L.; Sadowski, G.; Sagristà Sellés, T.; Sahlmann, J.; Salgado, J.; Salguero, E.; Sarasso, M.; Savietto, H.; Schnorhk, A.; Schultheis, M.; Sciacca, E.; Segol, M.; Segovia, J. C.; Segransan, D.; Serpell, E.; Shih, I.-C.; Smareglia, R.; Smart, R. L.; Smith, C.; Solano, E.; Solitro, F.; Sordo, R.; Soria Nieto, S.; Souchay, J.; Spagna, A.; Spoto, F.; Stampa, U.; Steele, I. A.; Steidelmüller, H.; Stephenson, C. A.; Stoev, H.; Suess, F. F.; Süveges, M.; Surdej, J.; Szabados, L.; Szegedi-Elek, E.; Tapiador, D.; Taris, F.; Tauran, G.; Taylor, M. B.; Teixeira, R.; Terrett, D.; Tingley, B.; Trager, S. C.; Turon, C.; Ulla, A.; Utrilla, E.; Valentini, G.; van Elteren, A.; Van Hemelryck, E.; van Leeuwen, M.; Varadi, M.; Vecchiato, A.; Veljanoski, J.; Via, T.; Vicente, D.; Vogt, S.; Voss, H.; Votruba, V.; Voutsinas, S.; Walmsley, G.; Weiler, M.; Weingrill, K.; Werner, D.; Wevers, T.; Whitehead, G.; Wyrzykowski, Ł.; Yoldas, A.; Žerjal, M.; Zucker, S.; Zurbach, C.; Zwitter, T.; Alecu, A.; Allen, M.; Allende Prieto, C.; Amorim, A.; Anglada-Escudé, G.; Arsenijevic, V.; Azaz, S.; Balm, P.; Beck, M.; Bernstein, H.-H.; Bigot, L.; Bijaoui, A.; Blasco, C.; Bonfigli, M.; Bono, G.; Boudreault, S.; Bressan, A.; Brown, S.; Brunet, P.-M.; Bunclark, P.; Buonanno, R.; Butkevich, A. G.; Carret, C.; Carrion, C.; Chemin, L.; Chéreau, F.; Corcione, L.; Darmigny, E.; de Boer, K. S.; de Teodoro, P.; de Zeeuw, P. T.; Delle Luche, C.; Domingues, C. D.; Dubath, P.; Fodor, F.; Frézouls, B.; Fries, A.; Fustes, D.; Fyfe, D.; Gallardo, E.; Gallegos, J.; Gardiol, D.; Gebran, M.; Gomboc, A.; Gómez, A.; Grux, E.; Gueguen, A.; Heyrovsky, A.; Hoar, J.; Iannicola, G.; Isasi Parache, Y.; Janotto, A.-M.; Joliet, E.; Jonckheere, A.; Keil, R.; Kim, D.-W.; Klagyivik, P.; Klar, J.; Knude, J.; Kochukhov, O.; Kolka, I.; Kos, J.; Kutka, A.; Lainey, V.; LeBouquin, D.; Liu, C.; Loreggia, D.; Makarov, V. V.; Marseille, M. G.; Martayan, C.; Martinez-Rubi, O.; Massart, B.; Meynadier, F.; Mignot, S.; Munari, U.; Nguyen, A.-T.; Nordlander, T.; Ocvirk, P.; O'Flaherty, K. S.; Olias Sanz, A.; Ortiz, P.; Osorio, J.; Oszkiewicz, D.; Ouzounis, A.; Palmer, M.; Park, P.; Pasquato, E.; Peltzer, C.; Peralta, J.; Péturaud, F.; Pieniluoma, T.; Pigozzi, E.; Poels, J.; Prat, G.; Prod'homme, T.; Raison, F.; Rebordao, J. M.; Risquez, D.; Rocca-Volmerange, B.; Rosen, S.; Ruiz-Fuertes, M. I.; Russo, F.; Sembay, S.; Serraller Vizcaino, I.; Short, A.; Siebert, A.; Silva, H.; Sinachopoulos, D.; Slezak, E.; Soffel, M.; Sosnowska, D.; Straižys, V.; ter Linden, M.; Terrell, D.; Theil, S.; Tiede, C.; Troisi, L.; Tsalmantza, P.; Tur, D.; Vaccari, M.; Vachier, F.; Valles, P.; Van Hamme, W.; Veltz, L.; Virtanen, J.; Wallut, J.-M.; Wichmann, R.; Wilkinson, M. I.; Ziaeepour, H.; Zschocke, S.

    2016-11-01

    Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page. http://www.cosmos.esa.int/gaia

  2. Evaluation of the Biological Activity of Opuntia ficus indica as a Tissue- and Estrogen Receptor Subtype-Selective Modulator.

    Science.gov (United States)

    An, Byoung Ha; Jeong, Hyesoo; Zhou, Wenmei; Liu, Xiyuan; Kim, Soolin; Jang, Chang Young; Kim, Hyun-Sook; Sohn, Johann; Park, Hye-Jin; Sung, Na-Hye; Hong, Cheol Yi; Chang, Minsun

    2016-06-01

    Phytoestrogens are selective estrogen receptor modulators (SERMs) with potential for use in hormone replacement therapy (HRT) to relieve peri/postmenopausal symptoms. This study was aimed at elucidating the molecular mechanisms underlying the SERM properties of the extract of Korean-grown Opuntia ficus-indica (KOFI). The KOFI extract induced estrogen response element (ERE)-driven transcription in breast and endometrial cancer cell lines and the expression of endogenous estrogen-responsive genes in breast cancer cells. The flavonoid content of different KOFI preparations affected ERE-luciferase activities, implying that the flavonoid composition likely mediated the estrogenic activities in cells. Oral administration of KOFI decreased the weight gain and levels of both serum glucose and triglyceride in ovariectomized (OVX) rats. Finally, KOFI had an inhibitory effect on the 17β-estradiol-induced proliferation of the endometrial epithelium in OVX rats. Our data demonstrate that KOFI exhibited SERM activity with no uterotrophic side effects. Therefore, KOFI alone or in combination with other botanical supplements, vitamins, or minerals may be an effective and safe alternative active ingredient to HRTs, for the management of postmenopausal symptoms. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  3. Implementation of a Service-learning Module in Medical Microbiology and Cell Biology Classes at an Undergraduate Liberal Arts University †

    Science.gov (United States)

    Larios-Sanz, Maia; Simmons, Alexandra D.; Bagnall, Ruth Ann; Rosell, Rosemarie C.

    2011-01-01

    Here we discuss the implementation of a service-learning module in two upper-division biology classes, Medical Microbiology and Cell Biology. This exciting hands-on learning experience provided our students with an opportunity to extend their learning of in-class topics to a real-life scenario. Students were required to volunteer their time (a minimum of 10 hours in a semester) at an under-served clinic in Houston, Texas. As they interacted with the personnel at the clinic, they were asked to identify the most prevalent disease (infectious for Medical Microbiology, and cellular-based for Cell) seen at the clinic and, working in groups, come up with educational material in the form of a display or brochure to be distributed to patients. The material was meant to educate patients about the disease in general terms, as well as how to recognize (symptoms), prevent and treat it. Students were required to keep a reflective journal in the form of a blog throughout the semester, and present their final materials to the class orally. Students were surveyed about their opinion of the experience at the end of the semester. The vast majority of student participants felt that the project was a positive experience and that it helped them develop additional skills beyond what they learn in the classroom and understand how lecture topics relate to every day life. PMID:23653736

  4. Arrays of microLEDs and astrocytes: biological amplifiers to optogenetically modulate neuronal networks reducing light requirement.

    Science.gov (United States)

    Berlinguer-Palmini, Rolando; Narducci, Roberto; Merhan, Kamyar; Dilaghi, Arianna; Moroni, Flavio; Masi, Alessio; Scartabelli, Tania; Landucci, Elisa; Sili, Maria; Schettini, Antonio; McGovern, Brian; Maskaant, Pleun; Degenaar, Patrick; Mannaioni, Guido

    2014-01-01

    In the modern view of synaptic transmission, astrocytes are no longer confined to the role of merely supportive cells. Although they do not generate action potentials, they nonetheless exhibit electrical activity and can influence surrounding neurons through gliotransmitter release. In this work, we explored whether optogenetic activation of glial cells could act as an amplification mechanism to optical neural stimulation via gliotransmission to the neural network. We studied the modulation of gliotransmission by selective photo-activation of channelrhodopsin-2 (ChR2) and by means of a matrix of individually addressable super-bright microLEDs (μLEDs) with an excitation peak at 470 nm. We combined Ca2+ imaging techniques and concurrent patch-clamp electrophysiology to obtain subsequent glia/neural activity. First, we tested the μLEDs efficacy in stimulating ChR2-transfected astrocyte. ChR2-induced astrocytic current did not desensitize overtime, and was linearly increased and prolonged by increasing μLED irradiance in terms of intensity and surface illumination. Subsequently, ChR2 astrocytic stimulation by broad-field LED illumination with the same spectral profile, increased both glial cells and neuronal calcium transient frequency and sEPSCs suggesting that few ChR2-transfected astrocytes were able to excite surrounding not-ChR2-transfected astrocytes and neurons. Finally, by using the μLEDs array to selectively light stimulate ChR2 positive astrocytes we were able to increase the synaptic activity of single neurons surrounding it. In conclusion, ChR2-transfected astrocytes and μLEDs system were shown to be an amplifier of synaptic activity in mixed corticalneuronal and glial cells culture.

  5. Arrays of microLEDs and astrocytes: biological amplifiers to optogenetically modulate neuronal networks reducing light requirement.

    Directory of Open Access Journals (Sweden)

    Rolando Berlinguer-Palmini

    Full Text Available In the modern view of synaptic transmission, astrocytes are no longer confined to the role of merely supportive cells. Although they do not generate action potentials, they nonetheless exhibit electrical activity and can influence surrounding neurons through gliotransmitter release. In this work, we explored whether optogenetic activation of glial cells could act as an amplification mechanism to optical neural stimulation via gliotransmission to the neural network. We studied the modulation of gliotransmission by selective photo-activation of channelrhodopsin-2 (ChR2 and by means of a matrix of individually addressable super-bright microLEDs (μLEDs with an excitation peak at 470 nm. We combined Ca2+ imaging techniques and concurrent patch-clamp electrophysiology to obtain subsequent glia/neural activity. First, we tested the μLEDs efficacy in stimulating ChR2-transfected astrocyte. ChR2-induced astrocytic current did not desensitize overtime, and was linearly increased and prolonged by increasing μLED irradiance in terms of intensity and surface illumination. Subsequently, ChR2 astrocytic stimulation by broad-field LED illumination with the same spectral profile, increased both glial cells and neuronal calcium transient frequency and sEPSCs suggesting that few ChR2-transfected astrocytes were able to excite surrounding not-ChR2-transfected astrocytes and neurons. Finally, by using the μLEDs array to selectively light stimulate ChR2 positive astrocytes we were able to increase the synaptic activity of single neurons surrounding it. In conclusion, ChR2-transfected astrocytes and μLEDs system were shown to be an amplifier of synaptic activity in mixed corticalneuronal and glial cells culture.

  6. Contribution of the modulation of intensity and the optimization to deliver a dose adapted to the biological heterogeneities

    International Nuclear Information System (INIS)

    Kubs, F.

    2007-10-01

    The recent progress in functional imaging by Positron Emission Tomography (TEP) opens new perspectives in the delineation of target volumes in radiotherapy. The functional data is major; we can intend to adapt the irradiation doses on the tumor activity (TA) and to perform a dose escalation. Our objectives were (i) to characterize the TEP threshold, by quantifying the uncertainties of the target volume contour according to the lesion size and the threshold contour level, (ii) to set up the geometry suited to perform a high-precision irradiation based on the TA, (iii) to estimate the dosimetric impact of this new protocol and (iv) to verify that dosimetry is perfectly distributed. Three original phantoms were specially created to satisfy the constraints met, as well as two virtual phantoms containing 3 dose levels (dose level 3 = TA). Our results showed the importance of the effect threshold-volume on the planning in radiotherapy. To use this irradiation method, the diameter of 1 cm for the third level was able to be reached. A dose escalation of 20 Gy was possible between the second (70 Gy) and the third level (90 Gy). The dosimetric impact estimated on two real cases was suitable - increase of COIN (conformal index) from 0.6 to 0.8 and decrease of NTCP (normal tissue complication probability) of a factor 5 -. In absolute and relative dosimetry, the clinical tolerances were respected. So all the treatment process, going from the diagnosis with the TEP to reveal the TA, to the patient treatment made beforehand on phantom, and going through the ballistic and the dose calculation, was estimated and validated according to our objective to adapt the irradiation to the biological heterogeneities. However such high doses should be carefully estimated before being prescribed clinically and progress is also expected in imaging, because the minimal size which we can irradiate is on the limit of the resolution TEP. (author)

  7. Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: a Multi-scale Computational Biological Approach

    Directory of Open Access Journals (Sweden)

    Cheryl L. Sershen

    2016-02-01

    Full Text Available In several mammalian hosts, including non-human primates, Mycobacterium tuberculosis granulomas are often hypoxic, although this has not been observed in wild type murine infection models. Mtb associated granuloma formation can be viewed as a structural immune response that can contain and halt the spread of the pathogen. While a presumed consequence, the structural contribution of the granuloma to oxygen limitation and the concomitant impact on Mtb metabolic viability and persistence remains to be fully explored.We develop a multi-scale computational model to test to what extent in vivo Mtb granulomas become hypoxic, and investigate the effects of hypoxia on host immune response efficacy and mycobacterial persistence. Our study integrates a model of oxygen dynamics in the extracellular space of alveolar tissue, an agent-based model of cellular immune response, and a systems biology-based model of Mtb metabolic dynamics. Our theoretical studies suggest that the dynamics of granuloma organization mediates oxygen availability and illustrates the immunological contribution of this structural host response to infection outcome. Furthermore, our integrated model demonstrates the link between structural immune response and mechanistic drivers influencing Mtb's adaptation to its changing microenvironment and the qualitative infection outcome scenarios: clearance, containment, dissemination, and a newly observed theoretical outcome of transient containment. We observed hypoxic regions in the containment granuloma similar in size to granulomas found in mammalian in vivo models of Mtb infection. In the case of the containment outcome, our model uniquely demonstrates that immune response mediated hypoxic conditions help foster the shift down of bacteria through the two stages of adaptation similar to thein vitro non-replicating persistence (NRP observed in the Wayne model of Mtb dormancy. The adaptation in part contributes to the ability of Mtb to remain

  8. Oxygen Modulates the Effectiveness of Granuloma Mediated Host Response to Mycobacterium tuberculosis: A Multiscale Computational Biology Approach

    Science.gov (United States)

    Sershen, Cheryl L.; Plimpton, Steven J.; May, Elebeoba E.

    2016-01-01

    Mycobacterium tuberculosis associated granuloma formation can be viewed as a structural immune response that can contain and halt the spread of the pathogen. In several mammalian hosts, including non-human primates, Mtb granulomas are often hypoxic, although this has not been observed in wild type murine infection models. While a presumed consequence, the structural contribution of the granuloma to oxygen limitation and the concomitant impact on Mtb metabolic viability and persistence remains to be fully explored. We develop a multiscale computational model to test to what extent in vivo Mtb granulomas become hypoxic, and investigate the effects of hypoxia on host immune response efficacy and mycobacterial persistence. Our study integrates a physiological model of oxygen dynamics in the extracellular space of alveolar tissue, an agent-based model of cellular immune response, and a systems biology-based model of Mtb metabolic dynamics. Our theoretical studies suggest that the dynamics of granuloma organization mediates oxygen availability and illustrates the immunological contribution of this structural host response to infection outcome. Furthermore, our integrated model demonstrates the link between structural immune response and mechanistic drivers influencing Mtbs adaptation to its changing microenvironment and the qualitative infection outcome scenarios of clearance, containment, dissemination, and a newly observed theoretical outcome of transient containment. We observed hypoxic regions in the containment granuloma similar in size to granulomas found in mammalian in vivo models of Mtb infection. In the case of the containment outcome, our model uniquely demonstrates that immune response mediated hypoxic conditions help foster the shift down of bacteria through two stages of adaptation similar to thein vitro non-replicating persistence (NRP) observed in the Wayne model of Mtb dormancy. The adaptation in part contributes to the ability of Mtb to remain dormant

  9. Autonomous Mission Operations

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Autonomous Mission Operations project will develop understanding of the impacts of increasing communication time delays on mission operations and develop...

  10. Spacelab mission 4 - The first dedicated life sciences mission

    Science.gov (United States)

    Perry, T. W.; Reid, D. H.

    1983-01-01

    Plans for the first Spacelab-4 mission dedicated entirely to the life sciences, are reviewed. The thrust of the scientific mission scheduled for late 1985 will be to study the acute effects of weightlessness on living systems, particularly humans. The payload of the Spacelab compartment will contain 24 experiments of which approximately half will involve humans. Among the major areas of interest are cardiovascular and pulmonary function, vestibular function, renal and endocrine physiology, hematology, nitrogen balance, immunological function, the gravitational biology of plants, inflight fertilization of frogs' eggs and the effects of zero gravity on monkeys and rats. In selecting the array of experiments an effort was made to combine investigations with complementary scientific objectives to develop animal models of human biological problems.

  11. Mission Complexity Scoring in Distributed Mission Training

    National Research Council Canada - National Science Library

    Denning, Todd

    2003-01-01

    ...) scenarios in terms of specific learning objectives linked to mission-essential competencies and to the underlying knowledge, skills, and experiences that are required for successful combat performance...

  12. Mission analysis for the Martian Moons Explorer (MMX) mission

    Science.gov (United States)

    Campagnola, Stefano; Yam, Chit Hong; Tsuda, Yuichi; Ogawa, Naoko; Kawakatsu, Yasuhiro

    2018-05-01

    Mars Moon eXplorer (MMX) is JAXA's next candidate flagship mission to be launched in the early 2020s. MMX will explore the Martian moons and return a sample from Phobos. This paper presents the mission analysis work, focusing on the transfer legs and comparing several architectures, such as hybrid options with chemical and electric propulsion modules. The selected baseline is a chemical-propulsion Phobos sample return, which is discussed in detail with the launch- and return-window analysis. The trajectories are optimized with the jTOP software, using planetary ephemerides for Mars and the Earth; Earth re-entry constraints are modeled with simple analytical equations. Finally, we introduce an analytical approximation of the three-burn capture strategy used in the Mars system. The approximation can be used together with a Lambert solver to quickly determine the transfer Δ v costs.

  13. Modular microfluidic system for biological sample preparation

    Science.gov (United States)

    Rose, Klint A.; Mariella, Jr., Raymond P.; Bailey, Christopher G.; Ness, Kevin Dean

    2015-09-29

    A reconfigurable modular microfluidic system for preparation of a biological sample including a series of reconfigurable modules for automated sample preparation adapted to selectively include a) a microfluidic acoustic focusing filter module, b) a dielectrophoresis bacteria filter module, c) a dielectrophoresis virus filter module, d) an isotachophoresis nucleic acid filter module, e) a lyses module, and f) an isotachophoresis-based nucleic acid filter.

  14. STS-40 Mission Insignia

    Science.gov (United States)

    1990-01-01

    The STS-40 patch makes a contemporary statement focusing on human beings living and working in space. Against a background of the universe, seven silver stars, interspersed about the orbital path of Columbia, represent the seven crew members. The orbiter's flight path forms a double-helix, designed to represent the DNA molecule common to all living creatures. In the words of a crew spokesman, ...(the helix) affirms the ceaseless expansion of human life and American involvement in space while simultaneously emphasizing the medical and biological studies to which this flight is dedicated. Above Columbia, the phrase Spacelab Life Sciences 1 defines both the Shuttle mission and its payload. Leonardo Da Vinci's Vitruvian man, silhouetted against the blue darkness of the heavens, is in the upper center portion of the patch. With one foot on Earth and arms extended to touch Shuttle's orbit, the crew feels, he serves as a powerful embodiment of the extension of human inquiry from the boundaries of Earth to the limitless laboratory of space. Sturdily poised amid the stars, he serves to link scentists on Earth to the scientists in space asserting the harmony of efforts which produce meaningful scientific spaceflight missions. A brilliant red and yellow Earth limb (center) links Earth to space as it radiates from a native American symbol for the sun. At the frontier of space, the traditional symbol for the sun vividly links America's past to America's future, the crew states. Beneath the orbiting Shuttle, darkness of night rests peacefully over the United States. Drawn by artist Sean Collins, the STS 40 Space Shuttle patch was designed by the crewmembers for the flight.

  15. Cubesat Gravity Field Mission

    Science.gov (United States)

    Burla, Santoshkumar; Mueller, Vitali; Flury, Jakob; Jovanovic, Nemanja

    2016-04-01

    CHAMP, GRACE and GOCE missions have been successful in the field of satellite geodesy (especially to improve Earth's gravity field models) and have established the necessity towards the next generation gravity field missions. Especially, GRACE has shown its capabilities beyond any other gravity field missions. GRACE Follow-On mission is going to continue GRACE's legacy which is almost identical to GRACE mission with addition of laser interferometry. But these missions are not only quite expensive but also takes quite an effort to plan and to execute. Still there are few drawbacks such as under-sampling and incapability of exploring new ideas within a single mission (ex: to perform different orbit configurations with multi satellite mission(s) at different altitudes). The budget is the major limiting factor to build multi satellite mission(s). Here, we offer a solution to overcome these drawbacks using cubesat/ nanosatellite mission. Cubesats are widely used in research because they are cheaper, smaller in size and building them is easy and faster than bigger satellites. Here, we design a 3D model of GRACE like mission with available sensors and explain how the Attitude and Orbit Control System (AOCS) works. The expected accuracies on final results of gravity field are also explained here.

  16. Overview of Key Saturn Probe Mission Trades

    Science.gov (United States)

    Balint, Tibor S.; Kowalkowski, Theresa; Folkner, Bill

    2007-01-01

    Ongoing studies, performed at NASA/JPL over the past two years in support of NASA's SSE Roadmap activities, proved the feasibility of a NF class Saturn probe mission. I. This proposed mission could also provide a good opportunity for international collaboration with the proposed Cosmic Vision KRONOS mission: a) With ESA contributed probes (descent modules) on a NASA lead mission; b) Early 2017 launch could be a good programmatic option for ESA-CV/NASA-NF. II. A number of mission architectures could be suitable for this mission: a) Probe Relay based architecture with short flight time (approx. 6.3-7 years); b) DTE probe telecom based architecture with long flight time (-11 years), and low probe data rate, but with the probes decoupled from the carrier, allowing for polar trajectories I orbiter. This option may need technology development for telecom; c) Orbiter would likely impact mission cost over flyby, but would provide significantly higher science return. The Saturn probes mission is expected to be identified in NASA's New Frontiers AO. Thus, further studies are recommended to refine the most suitable architecture. International collaboration is started through the KRONOS proposal work; further collaborated studies will follow once KRONOS is selected in October under ESA's Cosmic Vision Program.

  17. Dukovany ASSET mission preparation

    International Nuclear Information System (INIS)

    Kouklik, I.

    1996-01-01

    We are in the final stages of the Dukovany ASSET mission 1996 preparation. I would like to present some of our recent experiences. Maybe they would be helpful to other plants, that host ASSET missions in future

  18. BSPS Program (ESI-Mass Spectrometry) Biological Sample Data Analysis; Disruption of Bacteria Spores

    National Research Council Canada - National Science Library

    Lall, Ravi P

    2005-01-01

    The various biological processing technologies and biological identification approaches are essential for support of the mission to develop and demonstrate an advanced Biological Sample Preparation System...

  19. Mission operations management

    Science.gov (United States)

    Rocco, David A.

    1994-01-01

    Redefining the approach and philosophy that operations management uses to define, develop, and implement space missions will be a central element in achieving high efficiency mission operations for the future. The goal of a cost effective space operations program cannot be realized if the attitudes and methodologies we currently employ to plan, develop, and manage space missions do not change. A management philosophy that is in synch with the environment in terms of budget, technology, and science objectives must be developed. Changing our basic perception of mission operations will require a shift in the way we view the mission. This requires a transition from current practices of viewing the mission as a unique end product, to a 'mission development concept' built on the visualization of the end-to-end mission. To achieve this change we must define realistic mission success criteria and develop pragmatic approaches to achieve our goals. Custom mission development for all but the largest and most unique programs is not practical in the current budget environment, and we simply do not have the resources to implement all of our planned science programs. We need to shift our management focus to allow us the opportunity make use of methodologies and approaches which are based on common building blocks that can be utilized in the space, ground, and mission unique segments of all missions.

  20. "Cancer Cell Biology:" A Student-Centered Instructional Module Exploring the Use of Multimedia to Enrich Interactive, Constructivist Learning of Science

    Science.gov (United States)

    Bockholt, Susanne M.; West, J. Paige; Bollenbacher, Walter E.

    2003-01-01

    Multimedia has the potential of providing bioscience education novel learning environments and pedagogy applications to foster student interest, involve students in the research process, advance critical thinking/problem-solving skills, and develop conceptual understanding of biological topics. "Cancer Cell Biology," an interactive, multimedia,…

  1. Computer graphics aid mission operations. [NASA missions

    Science.gov (United States)

    Jeletic, James F.

    1990-01-01

    The application of computer graphics techniques in NASA space missions is reviewed. Telemetric monitoring of the Space Shuttle and its components is discussed, noting the use of computer graphics for real-time visualization problems in the retrieval and repair of the Solar Maximum Mission. The use of the world map display for determining a spacecraft's location above the earth and the problem of verifying the relative position and orientation of spacecraft to celestial bodies are examined. The Flight Dynamics/STS Three-dimensional Monitoring System and the Trajectroy Computations and Orbital Products System world map display are described, emphasizing Space Shuttle applications. Also, consideration is given to the development of monitoring systems such as the Shuttle Payloads Mission Monitoring System and the Attitude Heads-Up Display and the use of the NASA-Goddard Two-dimensional Graphics Monitoring System during Shuttle missions and to support the Hubble Space Telescope.

  2. Armstrong practices in Lunar Module simulator

    Science.gov (United States)

    1969-01-01

    Neil A. Armstrong, Commander for the Apollo 11 Moon-landing mission, practices for the historic event in a Lunar Module simulator in the Flight Crew Training building at KSC. Accompanying Armstrong on the Moon flight will be Command Module Pilot Michael Collins and Lunar Module Pilot Edwin E. Aldrin Jr.

  3. Approach to rapid mission design and planning. [earth orbit missions

    Science.gov (United States)

    Green, W. G.; Matthys, V. J.

    1973-01-01

    Methods and techniques are described for implementation in automated computer systems to assess parametric data, capabilities, requirements and constraints for planning earth orbit missions. Mission planning and design procedures are defined using two types of typical missions as examples. These missions were the high energy Astronomical Observatory Satellite missions, and Small Applications Technology Satellite missions.

  4. EXPOSE-R2: The Astrobiological ESA Mission on Board of the International Space Station

    Directory of Open Access Journals (Sweden)

    Elke Rabbow

    2017-08-01

    Full Text Available On July 23, 2014, the Progress cargo spacecraft 56P was launched from Baikonur to the International Space Station (ISS, carrying EXPOSE-R2, the third ESA (European Space Agency EXPOSE facility, the second EXPOSE on the outside platform of the Russian Zvezda module, with four international astrobiological experiments into space. More than 600 biological samples of archaea, bacteria (as biofilms and in planktonic form, lichens, fungi, plant seeds, triops eggs, mosses and 150 samples of organic compounds were exposed to the harsh space environment and to parameters similar to those on the Mars surface. Radiation dosimeters distributed over the whole facility complemented the scientific payload. Three extravehicular activities later the chemical samples were returned to Earth on March 2, 2016, with Soyuz 44S, having spent 588 days in space. The biological samples arrived back later, on June 18, 2016, with 45S, after a total duration in space of 531 days. The exposure of the samples to Low Earth Orbit vacuum lasted for 531 days and was divided in two parts: protected against solar irradiation during the first 62 days, followed by exposure to solar radiation during the subsequent 469 days. In parallel to the space mission, a Mission Ground Reference (MGR experiment with a flight identical Hardware and a complete flight identical set of samples was performed at the premises of DLR (German Aerospace Center in Cologne by MUSC (Microgravity User Support Center, according to the mission data either downloaded from the ISS (temperature data, facility status, inner pressure status or provided by RedShift Design and Engineering BVBA, Belgium (calculated ultra violet radiation fluence data. In this paper, the EXPOSE-R2 facility, the experimental samples, mission parameters, environmental parameters, and the overall mission and MGR sequences are described, building the background for the research papers of the individual experiments, their analysis and results.

  5. The STEREO Mission

    CERN Document Server

    2008-01-01

    The STEREO mission uses twin heliospheric orbiters to track solar disturbances from their initiation to 1 AU. This book documents the mission, its objectives, the spacecraft that execute it and the instruments that provide the measurements, both remote sensing and in situ. This mission promises to unlock many of the mysteries of how the Sun produces what has become to be known as space weather.

  6. Communication of 7 August 2007 from the Permanent Mission of Pakistan to the IAEA concerning the establishment of the oversight Board to monitor the implementation of Pakistan's export control on goods, technologies, materials and equipment related to nuclear and biological weapons and their Delivery Systems Act (Act No.V) 2004

    International Nuclear Information System (INIS)

    2007-01-01

    The Secretariat has received a Note Verbale dated 7 August 2007 from the Permanent Mission of Pakistan enclosing a copy of the Gazette of Pakistan S.R.O. No.693(I)/2007, dated 11 July 2007, regarding the establishment of the Oversight Board to monitor the implementation of Pakistan's Export Control on Goods, Technologies, Materials and Equipment related to Nuclear and Biological Weapons and their Delivery Systems Act (Act No.V) 2004, including the formation and functioning of Strategic Export Control Division. As requested in the Note Verbale, the Note Verbale and the enclosure thereto are circulated for the information of Member States

  7. Biologic Scaffolds.

    Science.gov (United States)

    Costa, Alessandra; Naranjo, Juan Diego; Londono, Ricardo; Badylak, Stephen F

    2017-09-01

    Biologic scaffold materials composed of allogeneic or xenogeneic extracellular matrix are commonly used for the repair and functional reconstruction of injured and missing tissues. These naturally occurring bioscaffolds are manufactured by the removal of the cellular content from source tissues while preserving the structural and functional molecular units of the remaining extracellular matrix (ECM). The mechanisms by which these bioscaffolds facilitate constructive remodeling and favorable clinical outcomes include release or creation of effector molecules that recruit endogenous stem/progenitor cells to the site of scaffold placement and modulation of the innate immune response, specifically the activation of an anti-inflammatory macrophage phenotype. The methods by which ECM biologic scaffolds are prepared, the current understanding of in vivo scaffold remodeling, and the associated clinical outcomes are discussed in this article. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

  8. Synthetic biology of polyketide synthases

    DEFF Research Database (Denmark)

    Yuzawa, Satoshi; Backman, Tyler W.H.; Keasling, Jay D.

    2018-01-01

    ). The modules are composed of enzymatic domains that share sequence and functional similarity across all known PKSs. We have used the nomenclature of synthetic biology to classify the enzymatic domains and modules as parts and devices, respectively, and have generated detailed lists of both. In addition, we...... realize the potential that synthetic biology approaches bring to this class of molecules....

  9. Bering Mission Navigation Method

    DEFF Research Database (Denmark)

    Betto, Maurizio; Jørgensen, John Leif; Jørgensen, Peter Siegbjørn

    2003-01-01

    "Bering", after the name of the famous Danish explorer, is a near Earth object (NEO) and main belt asteroids mapping mission envisaged by a consortium of Danish universities and research institutes. To achieve the ambitious goals set forth by this mission, while containing the costs and risks...

  10. Crew portrait during 51-B mission

    Science.gov (United States)

    1985-01-01

    Crew portrait during 51-B mission. Note the gold T-shirts of 'gold' team members Robert F. Overmyer (bottom left), Don L. Lind (behind Overmyer), William E. Thornton (bottom right) and Taylor G. Wang (behind Thornton). Posing 'upside down' are 'silver team members (l.-r.) Frederick D. Gregory, Norman E. Thagard and Lodewijk van den Berg. The seven are in the long science module for Spacelab 3 in the cargo bay of the Shuttle Challenger.

  11. Venus 2000 Mission Design

    Science.gov (United States)

    Folta, David; Marr, Greg; Vaughn, Frank; Houghton, Martin B.

    1997-01-01

    As part of the Discovery Program, National Aeronautics and Space Administration (NASA) has solicited proposals for inter-planetary research to conduct solar system exploration science investigations. A mission, called Venus 2000 (V2k), has been proposed for exploration of the Venus Atmosphere. This is NASAs first voyage to Venus to investigate key science objectives since Magellan and will be launched in summer 2002. In keeping with discovery program requirements to reduce total mission cost and utilize new technology, V2k mission design and control will focus on the use of innovative and proven trajectory analysis programs and control systems provided by the Goddard Space Flight Center (GSFC).

  12. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.

    Science.gov (United States)

    Asano, Moriteru; Hitaka, Takenori; Imada, Takashi; Yamada, Masami; Morimoto, Megumi; Shinohara, Hiromi; Hara, Takahito; Yamaoka, Masuo; Santou, Takashi; Nakayama, Masaharu; Imai, Yumi; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Hasuoka, Atsushi

    2017-05-01

    We recently reported a class of novel tissue-selective androgen receptor modulators (SARMs), represented by a naphthalene derivative A. However, their pharmacokinetic (PK) profiles were poor due to low metabolic stability. To improve the PK profiles, we modified the hydroxypyrrolidine and benzonitrile substituents of 4-(pyrrolidin-1-yl)benzonitrile derivative B, which had a comparable potency as that of compound A. This optimization led us to further modifications, which improved metabolic stability while maintaining potent androgen agonistic activity. Among the synthesized compounds, (2S,3S)-2,3-dimethyl-3-hydroxylpyrrolidine derivative 1c exhibited a suitable PK profile and improved metabolic stability. Compound 1c demonstrated significant efficacy in levator ani muscle without increasing the weight of the prostate in an in vivo study. In addition, compound 1c showed agonistic activity in the CNS, which was detected using sexual behavior induction assay. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Microgravity Fluids for Biology, Workshop

    Science.gov (United States)

    Griffin, DeVon; Kohl, Fred; Massa, Gioia D.; Motil, Brian; Parsons-Wingerter, Patricia; Quincy, Charles; Sato, Kevin; Singh, Bhim; Smith, Jeffrey D.; Wheeler, Raymond M.

    2013-01-01

    Microgravity Fluids for Biology represents an intersection of biology and fluid physics that present exciting research challenges to the Space Life and Physical Sciences Division. Solving and managing the transport processes and fluid mechanics in physiological and biological systems and processes are essential for future space exploration and colonization of space by humans. Adequate understanding of the underlying fluid physics and transport mechanisms will provide new, necessary insights and technologies for analyzing and designing biological systems critical to NASAs mission. To enable this mission, the fluid physics discipline needs to work to enhance the understanding of the influence of gravity on the scales and types of fluids (i.e., non-Newtonian) important to biology and life sciences. In turn, biomimetic, bio-inspired and synthetic biology applications based on physiology and biology can enrich the fluid mechanics and transport phenomena capabilities of the microgravity fluid physics community.

  14. Executive Summary - Our mission

    International Nuclear Information System (INIS)

    2005-01-01

    On September 1 st 2003, the Henryk Niewodniczanski Institute of Nuclear Physics in Cracow joined the Polish Academy of Sciences. The Polish Academy of Sciences (PAN), founded in 1952, is a state-sponsored scientific institution acting through an elected corporation of leading scholars, their research organizations and through numerous scientific establishments. PAN is a major national scientific advisory body acting via its scientific committees which represent all disciplines of science. There are currently 79 PAN research establishments (institutes and research centers, research stations, botanical gardens and other research units) and a number of auxiliary scientific units (such as archives, libraries, museums, and PAN stations abroad). Our Institute is currently one of the largest research institutions of the Polish Academy of Sciences. The research activity of the Academy is financed mainly from the State budget via the Ministry of Scientific Research and Information Technology. The mission of the Institute of Nuclear Physics, IFJ is stated in its Charter. According to Paragraphs 5, 6, and 7 of the 2004 Charter, the Institute's duty is to carry out research activities in the following areas:1. High energy and elementary particle physics (including astrophysics), 2. Nuclear physics and physics of mechanisms of nuclear interaction, 3. Condensed matter physics, 4. Interdisciplinary research, and in particular: in radiation and environmental biology, environmental physics, medical physics, dosimetry, nuclear geophysics, radiochemistry and material engineering. The main tasks of the Institute are: 1. To perform research in the above disciplines, 2. To promote the development of scientists and of specialists qualified to carry out research in these disciplines, 3. To organize a Post-Doctoral Study Course, 4. To permit, through agreements with national and foreign research institutions, external scholars to train and gain academic qualifications in the Institute

  15. PLA Missions Beyond Taiwan

    National Research Council Canada - National Science Library

    Miller, Marc

    2008-01-01

    KEY INSIGHTS: *The PLA is being assigned and training for an increasing variety of missions, including nontraditional battlefields such as outer space and cyber space, as well as nontraditional functions...

  16. Uganda Mission PRS

    Data.gov (United States)

    US Agency for International Development — A web-based performance reporting system that is managed by IBI that interfaces with the Mission's GIS database that supports USAID/Uganda and its implementing...

  17. NEP missions to Pluto

    International Nuclear Information System (INIS)

    Lipinski, Ronald J.

    2002-01-01

    Nuclear Electric Propulsion (NEP) has the potential to deliver fast trips to the distant outer planets and to be enabling for orbiter missions to Pluto, the moons of the distant outer planets, and Kuiper belt objects. This paper summarizes results of a mission study for a Pluto Flyby and a Pluto Orbiter. It was concluded that the flyby mission trip time would be about 6-10 years, depending on how lightweight the power system could be made for a given power level. The trip time was not too sensitive to whether the initial condition was earth escape or earth orbit if a larger power system could be assumed for the earth-orbit option because of the larger launch mass that could be used in that case. The trip time for the orbiter mission was projected to be about 9-14 years

  18. MISSION MOUNTAINS WILDERNESS, MONTANA.

    Science.gov (United States)

    Harrison, Jack E.; Pattee, Eldon C.

    1984-01-01

    The Mission Mountains Wilderness occupies an area from the crest of the Mission Range eastward toward the valley of the Swam River in western Montana. A mineral survey of the area was conducted. No evidence of metallic or energy resources was identified during the course of this study. An intensive search for stratabound copper-silver sulfides in the area found only sporadic and insignificant occurrences in surface strata.

  19. NEEMO 7 undersea mission

    Science.gov (United States)

    Thirsk, Robert; Williams, David; Anvari, Mehran

    2007-02-01

    The NEEMO 7 mission was the seventh in a series of NASA-coordinated missions utilizing the Aquarius undersea habitat in Florida as a human space mission analog. The primary research focus of this mission was to evaluate telementoring and telerobotic surgery technologies as potential means to deliver medical care to astronauts during spaceflight. The NEEMO 7 crewmembers received minimal pre-mission training to perform selected medical and surgical procedures. These procedures included: (1) use of a portable ultrasound to locate and measure abdominal organs and structures in a crewmember subject; (2) use of a portable ultrasound to insert a small needle and drain into a fluid-filled cystic cavity in a simulated patient; (3) surgical repair of two arteries in a simulated patient; (4) cystoscopy and use of a ureteral basket to remove a renal stone in a simulated patient; and (5) laparoscopic cholecystectomy in a simulated patient. During the actual mission, the crewmembers performed the procedures without or with telementoring and telerobotic assistance from experts located in Hamilton, Ontario. The results of the NEEMO 7 medical experiments demonstrated that telehealth interventions rely heavily on a robust broadband, high data rate telecommunication link; that certain interventional procedures can be performed adequately by minimally trained individuals with telementoring assistance; and that prior clinical experience does not always correlate with better procedural performance. As space missions become longer in duration and take place further from Earth, enhancement of medical care capability and expertise will be required. The kinds of medical technologies demonstrated during the NEEMO 7 mission may play a significant role in enabling the human exploration of space beyond low earth orbit, particularly to destinations such as the Moon and Mars.

  20. Colombia: Updating the Mission

    Science.gov (United States)

    2011-09-01

    or La Violencia . Bogota was nearly destroyed, and the bloodshed spilled into the countryside where it reached its greatest intensity. The machete...role and its commitment to its assigned mission. Army Mission During La Violencia (1948–1962) Of course, it is the army that we are par- ticularly...result was Colombia’s costli- est civil war, termed simply The Violence, or La Violencia . Bogota was nearly destroyed, and the bloodshed spilled into

  1. Space Mission Utility and Requirements for a Heat Melt Compactor

    Science.gov (United States)

    Fisher, John W.; Lee, Jeffrey M.

    2016-01-01

    Management of waste on long-duration space missions is both a problem and an opportunity. Uncontained or unprocessed waste is a crew health hazard and a habitat storage problem. A Heat Melt Compactor (HMC) such as NASA has been developing is capable of processing space mission trash and converting it to useful products. The HMC is intended to process space mission trash to achieve a number of objectives including: volume reduction, biological safening and stabilization, water recovery, radiation shielding, and planetary protection. This paper explores the utility of the HMC to future space missions and how this translates into HMC system requirements.

  2. Search for extraterrestrial planets: the DARWIN mission

    Science.gov (United States)

    d'Arcio, Luigi; Karlsson, Anders; Bavdaz, Marcos; Jagemann, Thomas

    2017-11-01

    The ESA Darwin mission is primarily devoted to the detection of earth-like exoplanets and the spectroscopic characterization of their atmospheres for key tracers of life. Darwin is implemented as a free-flying stellar interferometer operating in the 6.5-20 micron wavelength range, and passively cooled to 40 K. The stellar flux is suppressed by destructive interference (nulling) over the full optical bandwidth. The planetary signal is extracted from the zodiacal background signature by modulating the optical response of the interferometer. The Darwin mission concept has evolved considerably in the past years. The original concept, based on six 1.5 m telescopes, has been replaced by more efficient designs using three to four three-meter class apertures. A novel 3D architecture is being evaluated, together with the conventional planar one, bearing the potential for significant volume and mass savings and enhanced straylight rejection. A number of technology development activities have been successfully completed, including optical metrology, optical delay lines, and single-mode infrared optical fibers. A second iteration of the Darwin System Assessment Study has been kicked off end 2005, aiming to consolidate the overall mission architecture and the preliminary design of the Darwin mission concept. This paper illustrates the current status of the Darwin mission, with special emphasis on the optical configuration and the technology development programme in the area of optics.

  3. Precipitation Measurement Missions Data Access

    Data.gov (United States)

    National Aeronautics and Space Administration — Tropical Rainfall Measuring Mission (TRMM) data products are currently available from 1998 to the present. Global Precipitation Measurement (GPM) mission data...

  4. Lunar Prospector Extended Mission

    Science.gov (United States)

    Folta, David; Beckman, Mark; Lozier, David; Galal, Ken

    1999-01-01

    The National Aeronautics and Space Administration (NASA) selected Lunar Prospector (LP) as one of the discovery missions to conduct solar system exploration science investigations. The mission is NASA's first lunar voyage to investigate key science objectives since Apollo and was launched in January 1998. In keeping with discovery program requirements to reduce total mission cost and utilize new technology, Lunar Prospector's mission design and control focused on the use of innovative and proven trajectory analysis programs. As part of this effort, the Ames Research Center and the Goddard Space Flight Center have become partners in the Lunar Prospector trajectory team to provide the trajectory analysis, maneuver planning, orbit determination support, and product generation. At the end of 1998, Lunar Prospector completed its one-year primary mission at 100 km altitude above the lunar surface. On December 19, 1998, Lunar Prospector entered the extended mission phase. Initially the mission orbit was lowered from 100 km to a mean altitude of 40 km. The altitude of Lunar Prospector varied between 25 and 55 km above the mean lunar geode due to lunar potential effects. After one month, the lunar potential model was updated based upon the new tracking data at 40 km. On January 29, 1999, the altitude was lowered again to a mean altitude of 30 km. This altitude varies between 12 and 48 km above the mean lunar geode. Since the minimum altitude is very close to the mean geode, various approaches were employed to get accurate lunar surface elevation including Clementine altimetry and line of sight analysis. Based upon the best available terrain maps, Lunar Prospector will reach altitudes of 8 km above lunar mountains in the southern polar and far side regions. This extended mission phase of six months will enable LP to obtain science data up to 3 orders of magnitude better than at the mission orbit. This paper details the trajectory design and orbit determination planning and

  5. Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability

    Directory of Open Access Journals (Sweden)

    David H. Dreyfus

    2017-01-01

    Full Text Available Epstein-Barr virus, a ubiquitous human herpesvirus, is associated through epidemiologic evidence with common autoimmune syndromes and cancers. However, specific genetic mechanisms of pathogenesis have been difficult to identify. In this review, the author summarizes evidence that recently discovered noncoding RNAs termed microRNA encoded by Epstein-Barr virus BARF (BamHI A right frame termed BART (BamHI A right transcripts are modulators of human immune response genes and genome stability in infected and bystander cells. BART expression is apparently regulated by complex feedback loops with the host immune response regulatory NF-κB transcription factors. EBV-encoded BZLF-1 (ZEBRA protein could also regulate BART since ZEBRA contains a terminal region similar to ankyrin proteins such as IκBα that regulate host NF-κB. BALF-2 (BamHI A left frame transcript, a viral homologue of the immunoglobulin and T cell receptor gene recombinase RAG-1 (recombination-activating gene-1, may also be coregulated with BART since BALF-2 regulatory sequences are located near the BART locus. Viral-encoded microRNA and viral mRNA transferred to bystander cells through vesicles, defective viral particles, or other mechanisms suggest a new paradigm in which bystander or hit-and-run mechanisms enable the virus to transiently or chronically alter human immune response genes as well as the stability of the human genome.

  6. Contribution of the modulation of intensity and the optimization to deliver a dose adapted to the biological heterogeneities; Apport de la modulation d'intensite et de l'optimisation pour delivrer une dose adaptee aux heterogeneites biologiques

    Energy Technology Data Exchange (ETDEWEB)

    Kubs, F

    2007-10-15

    The recent progress in functional imaging by Positron Emission Tomography (TEP) opens new perspectives in the delineation of target volumes in radiotherapy. The functional data is major; we can intend to adapt the irradiation doses on the tumor activity (TA) and to perform a dose escalation. Our objectives were (i) to characterize the TEP threshold, by quantifying the uncertainties of the target volume contour according to the lesion size and the threshold contour level, (ii) to set up the geometry suited to perform a high-precision irradiation based on the TA, (iii) to estimate the dosimetric impact of this new protocol and (iv) to verify that dosimetry is perfectly distributed. Three original phantoms were specially created to satisfy the constraints met, as well as two virtual phantoms containing 3 dose levels (dose level 3 = TA). Our results showed the importance of the effect threshold-volume on the planning in radiotherapy. To use this irradiation method, the diameter of 1 cm for the third level was able to be reached. A dose escalation of 20 Gy was possible between the second (70 Gy) and the third level (90 Gy). The dosimetric impact estimated on two real cases was suitable - increase of COIN (conformal index) from 0.6 to 0.8 and decrease of NTCP (normal tissue complication probability) of a factor 5 -. In absolute and relative dosimetry, the clinical tolerances were respected. So all the treatment process, going from the diagnosis with the TEP to reveal the TA, to the patient treatment made beforehand on phantom, and going through the ballistic and the dose calculation, was estimated and validated according to our objective to adapt the irradiation to the biological heterogeneities. However such high doses should be carefully estimated before being prescribed clinically and progress is also expected in imaging, because the minimal size which we can irradiate is on the limit of the resolution TEP. (author)

  7. Mission operations technology

    Science.gov (United States)

    Varsi, Giulio

    In the last decade, the operation of a spacecraft after launch has emerged as a major component of the total cost of the mission. This trend is sustained by the increasing complexity, flexibility, and data gathering capability of the space assets and by their greater reliability and consequent longevity. The trend can, however, be moderated by the progressive transfer of selected functions from the ground to the spacecraft and by application, on the ground, of new technology. Advances in ground operations derive from the introduction in the mission operations environment of advanced microprocessor-based workstations in the class of a few million instructions per second and from the selective application of artificial intelligence technology. In the last few years a number of these applications have been developed, tested in operational settings and successfully demonstrated to users. Some are now being integrated in mission operations facilities. An analysis of mission operations indicates that the key areas are: concurrent control of multiple missions; automated/interactive production of command sequences of high integrity at low cost; automated monitoring of spacecraft health and automated aides for fault diagnosis; automated allocation of resources; automated processing of science data; and high-fidelity, high-speed spacecraft simulation. Examples of major advances in selected areas are described.

  8. Athena Mission Status

    Science.gov (United States)

    Lumb, D.

    2016-07-01

    Athena has been selected by ESA for its second large mission opportunity of the Cosmic Visions programme, to address the theme of the Hot and Energetic Universe. Following the submission of a proposal from the community, the technical and programmatic aspects of the mission design were reviewed in ESA's Concurrent Design Facility. The proposed concept was deemed to betechnically feasible, but with potential constraints from cost and schedule. Two parallel industry study contracts have been conducted to explore these conclusions more thoroughly, with the key aim of providing consolidated inputs to a Mission Consolidation Review that was conducted in April-May 2016. This MCR has recommended a baseline design, which allows the agency to solicit proposals for a community provided payload. Key design aspects arising from the studies are described, and the new reference design is summarised.

  9. Country programming mission. Namibia

    International Nuclear Information System (INIS)

    1991-01-01

    In response to a request from the Government of Namibia conveyed in a letter dated 29 November 1990 IAEA provided a multi-disciplinary Programming Mission which visited Namibia from 15 - 19 July 1991. The terms of reference of the Mission were: 1. To assess the possibilities and benefits of nuclear energy applications in Namibia's development; 2. To advise on the infrastructure required for nuclear energy projects; 3. To assist in the formulation of project proposals which could be submitted for Agency assistance. This report is based on the findings of the Mission and falls into 3 sections with 8 appendices. The first section is a country profile providing background information, the second section deals with sectorial needs and institutional review of the sectors of agriculture including animal production, life sciences (nuclear medicine and radiotherapy) and radiation protection. The third section includes possible future technical co-operation activities

  10. Trial-by-Trial Modulation of Associative Memory Formation by Reward Prediction Error and Reward Anticipation as Revealed by a Biologically Plausible Computational Model.

    Science.gov (United States)

    Aberg, Kristoffer C; Müller, Julia; Schwartz, Sophie

    2017-01-01

    Anticipation and delivery of rewards improves memory formation, but little effort has been made to disentangle their respective contributions to memory enhancement. Moreover, it has been suggested that the effects of reward on memory are mediated by dopaminergic influences on hippocampal plasticity. Yet, evidence linking memory improvements to actual reward computations reflected in the activity of the dopaminergic system, i.e., prediction errors and expected values, is scarce and inconclusive. For example, different previous studies reported that the magnitude of prediction errors during a reinforcement learning task was a positive, negative, or non-significant predictor of successfully encoding simultaneously presented images. Individual sensitivities to reward and punishment have been found to influence the activation of the dopaminergic reward system and could therefore help explain these seemingly discrepant results. Here, we used a novel associative memory task combined with computational modeling and showed independent effects of reward-delivery and reward-anticipation on memory. Strikingly, the computational approach revealed positive influences from both reward delivery, as mediated by prediction error magnitude, and reward anticipation, as mediated by magnitude of expected value, even in the absence of behavioral effects when analyzed using standard methods, i.e., by collapsing memory performance across trials within conditions. We additionally measured trait estimates of reward and punishment sensitivity and found that individuals with increased reward (vs. punishment) sensitivity had better memory for associations encoded during positive (vs. negative) prediction errors when tested after 20 min, but a negative trend when tested after 24 h. In conclusion, modeling trial-by-trial fluctuations in the magnitude of reward, as we did here for prediction errors and expected value computations, provides a comprehensive and biologically plausible description of

  11. The OICETS mission

    Science.gov (United States)

    Jono, Takashi; Arai, Katsuyoshi

    2017-11-01

    The Optical Inter-orbit Communications Engineering Test Satellite (OICETS) was successfully launched on 23th August 2005 and thrown into a circular orbit at the altitude of 610 km. The main mission is to demonstrate the free-space inter satellite laser communications with the cooperation of the Advanced Relay and Technology Mission (ARTEMIS) geostationary satellite developed by the European Space Agency. This paper presents the overview of the OICETS and laser terminal, a history of international cooperation between Japan Aerospace Exploration Agency (JAXA) and ESA and typical results of the inter-orbit laser communication experiment carried out with ARTEMIS.

  12. The Asteroid Impact Mission

    Science.gov (United States)

    Carnelli, Ian; Galvez, Andres; Mellab, Karim

    2016-04-01

    The Asteroid Impact Mission (AIM) is a small and innovative mission of opportunity, currently under study at ESA, intending to demonstrate new technologies for future deep-space missions while addressing planetary defense objectives and performing for the first time detailed investigations of a binary asteroid system. It leverages on a unique opportunity provided by asteroid 65803 Didymos, set for an Earth close-encounter in October 2022, to achieve a fast mission return in only two years after launch in October/November 2020. AIM is also ESA's contribution to an international cooperation between ESA and NASA called Asteroid Impact Deflection Assessment (AIDA), consisting of two mission elements: the NASA Double Asteroid Redirection Test (DART) mission and the AIM rendezvous spacecraft. The primary goals of AIDA are to test our ability to perform a spacecraft impact on a near-Earth asteroid and to measure and characterize the deflection caused by the impact. The two mission components of AIDA, DART and AIM, are each independently valuable but when combined they provide a greatly increased scientific return. The DART hypervelocity impact on the secondary asteroid will alter the binary orbit period, which will also be measured by means of lightcurves observations from Earth-based telescopes. AIM instead will perform before and after detailed characterization shedding light on the dependence of the momentum transfer on the asteroid's bulk density, porosity, surface and internal properties. AIM will gather data describing the fragmentation and restructuring processes as well as the ejection of material, and relate them to parameters that can only be available from ground-based observations. Collisional events are of great importance in the formation and evolution of planetary systems, own Solar System and planetary rings. The AIDA scenario will provide a unique opportunity to observe a collision event directly in space, and simultaneously from ground-based optical and

  13. Reference mission 3B ascent trajectory. Mission planning, mission analysis and software formulation

    Science.gov (United States)

    Kuhn, A. E.

    1975-01-01

    Mission 3B is designed as a payload retrieval mission with both shuttle launch and orbiter landing to take place at the western test range. The mission is designed for direct rendezvous with a passive satellite in a 100 NMI circular orbit with an inclination of 104 degrees. The ascent portion of mission 3B is described as well as the trajectory simulation.

  14. Investigation of Bio-Regenerative Life Support and Trash-to-Gas Experiment on a 4-Month Mars Simulation Mission

    Science.gov (United States)

    Caraccio, Anne; Poulet, Lucie; Hintze, Paul E.; Miles, John D.

    2014-01-01

    Future crewed missions to other planets or deep space locations will require regenerative Life Support Systems (LSS) as well as recycling processes for mission waste. Constant resupply of many commodity materials will not be a sustainable option for deep space missions, nor will stowing trash on board a vehicle or at a lunar or Martian outpost. The habitable volume will decline as the volume of waste increases. A complete regenerative environmentally controlled life support system (ECLSS) on an extra-terrestrial outpost will likely include physico-chemical and biological technologies, such as bioreactors and greenhouse modules. Physico-chemical LSS do not enable food production and bio-regenerative LSS are not stable enough to be used alone in space. Mission waste that cannot be recycled into the bio-regenerative ECLSS can include excess food, food packaging, clothing, tape, urine and fecal waste. This waste will be sent to a system for converting the trash into high value products. Two crew members on a 120 day Mars analog simulation, in collaboration with Kennedy Space Centers (KSC) Trash to Gas (TtG) project investigated a semi-closed loop system that treated non-edible biomass and other logistical waste for volume reduction and conversion into useful commodities. The purpose of this study is to show how plant growth affects the amount of resources required by the habitat and how spent plant material can be recycled. Real-time data was sent to the reactor at KSC in Florida for replicating the analog mission waste for laboratory operation. This paper discusses the 120 day mission plant growth activity, logistical and plant waste management, power and water consumption effects of the plant and logistical waste, and potential energy conversion techniques using KSCs TtG technology.

  15. Investigation of Bio-Regenerative Life Support and Trash-To-Gas Experiment on a 4 Month Mars Simulation Mission

    Science.gov (United States)

    Caraccio, Anne; Poulet, Lucie; Hintze, Paul E.; Miles, John D.

    2014-01-01

    Future crewed missions to other planets or deep space locations will require regenerative Life Support Systems (LSS) as well as recycling processes for mission waste. Constant resupply of many commodity materials will not be a sustainable option for deep space missions, nor will storing trash on board a vehicle or at a lunar or Martian outpost. The habitable volume will decline as the volume of waste increases. A complete regenerative environmentally controlled life support system (ECLSS) on an extra-terrestrial outpost will likely include physico-chemical and biological technologies, such as bioreactors and greenhouse modules. Physico-chemical LSS do not enable food production and bio-regenerative LSS are not stable enough to be used alone in space. Mission waste that cannot be recycled into the bio-regenerative ECLSS can include excess food, food packaging, clothing, tape, urine and fecal waste. This waste will be sent to a system for converting the trash into the high value products. Two crew members on a 120 day Mars analog simulation, in collaboration with Kennedy Space Centers (KSC) Trash to Gas (TtG) project investigated a semi-closed loop system that treated non-edible biomass and other logistical waste for volume reduction and conversion into useful commodities. The purposes of this study are to show the how plant growth affects the amount of resources required by the habitat and how spent plant material can be recycled. Real-time data was sent to the reactor at KSC in Florida for replicating the analog mission waste for laboratory operation. This paper discusses the 120 day mission plant growth activity, logistical and plant waste management, power and water consumption effects of the plant and logistical waste, and potential energy conversion techniques using KSCs TtG reactor technology.

  16. Long term operation of nuclear power plants – IAEA SALTO missions observations and trends

    International Nuclear Information System (INIS)

    Krivanek, Robert; Havel, Radim

    2016-01-01

    Highlights: • During the period 2005–mid 2015, 22 SALTO peer review missions and 2 LTO modules of OSART missions were conducted. • Analysis of these mission results and main trends observed are gathered in this paper. • The main task of the assessment performed was to evaluate and give a weight to the evaluation. • Results of SALTO follow-up missions as well as OSART follow-up missions with LTO module are summarized. • The SALTO peer review service is strongly recommended for NPPs prior to entering LTO period. - Abstract: This paper builds on paper “Long term operation of nuclear power plants – IAEA SALTO peer review service and its results”, NED8070, presented in Nuclear Engineering and Design in September 2014. This paper presents the analysis of SALTO mission results and main trends observed so that all the most important results of SALTO missions are gathered in one paper. The paper also includes the results of LTO module reviews performed in the frame of OSART missions where applicable as well as follow-up missions. This paper is divided in three main Sections. Section 1 provides brief introduction to SALTO peer review service. Section 2 provides overview of performed SALTO missions and LTO modules of OSART missions performed between 2005 and mid-2015. Section 3 summarizes the most significant observations and trends resulting from the missions between 2005 and mid-2015. Section 4 summarizes the results of SALTO follow-up missions as well as OSART follow-up missions.

  17. EOS Aura Mission Status

    Science.gov (United States)

    Guit, William J.

    2015-01-01

    This PowerPoint presentation will discuss EOS Aura mission and spacecraft subsystem summary, recent and planned activities, inclination adjust maneuvers, propellant usage lifetime estimate. Eric Moyer, ESMO Deputy Project Manager-Technical (code 428) has reviewed and approved the slides on April 30, 2015.

  18. Towards A Shared Mission

    DEFF Research Database (Denmark)

    Staunstrup, Jørgen; Orth Gaarn-Larsen, Carsten

    A mission shared by stakeholders, management and employees is a prerequisite for an engaging dialog about the many and substantial changes and challenges currently facing universities. Too often this essen-tial dialog reveals mistrust and misunderstandings about the role and outcome of the univer...

  19. Robust UAV mission planning

    NARCIS (Netherlands)

    Evers, L.; Dollevoet, T.; Barros, A.I.; Monsuur, H.

    2011-01-01

    Unmanned Areal Vehicles (UAVs) can provide significant contributions to information gathering in military missions. UAVs can be used to capture both full motion video and still imagery of specific target locations within the area of interest. In order to improve the effectiveness of a reconnaissance

  20. Mission Operations Assurance

    Science.gov (United States)

    Faris, Grant

    2012-01-01

    Integrate the mission operations assurance function into the flight team providing: (1) value added support in identifying, mitigating, and communicating the project's risks and, (2) being an essential member of the team during the test activities, training exercises and critical flight operations.

  1. Mission from Mars

    DEFF Research Database (Denmark)

    Dindler, Christian; Eriksson, Eva; Iversen, Ole Sejer

    2005-01-01

    In this paper a particular design method is propagated as a supplement to existing descriptive approaches to current practice studies especially suitable for gathering requirements for the design of children's technology. The Mission from Mars method was applied during the design of an electronic...

  2. KEEL for Mission Planning

    Science.gov (United States)

    2016-10-06

    Alternatives are balanced to achieve the best overall outcome. Then, once deployed and when things don’t go as expected, the mission aborts, is redefined...cognitive technology for application in automotive , industrial automation, medical, military, governmental, enterprise software and electronic gaming

  3. The Double Star mission

    Directory of Open Access Journals (Sweden)

    Liu

    2005-11-01

    Full Text Available The Double Star Programme (DSP was first proposed by China in March, 1997 at the Fragrant Hill Workshop on Space Science, Beijing, organized by the Chinese Academy of Science. It is the first mission in collaboration between China and ESA. The mission is made of two spacecraft to investigate the magnetospheric global processes and their response to the interplanetary disturbances in conjunction with the Cluster mission. The first spacecraft, TC-1 (Tan Ce means "Explorer", was launched on 29 December 2003, and the second one, TC-2, on 25 July 2004 on board two Chinese Long March 2C rockets. TC-1 was injected in an equatorial orbit of 570x79000 km altitude with a 28° inclination and TC-2 in a polar orbit of 560x38000 km altitude. The orbits have been designed to complement the Cluster mission by maximizing the time when both Cluster and Double Star are in the same scientific regions. The two missions allow simultaneous observations of the Earth magnetosphere from six points in space. To facilitate the comparison of data, half of the Double Star payload is made of spare or duplicates of the Cluster instruments; the other half is made of Chinese instruments. The science operations are coordinated by the Chinese DSP Scientific Operations Centre (DSOC in Beijing and the European Payload Operations Service (EPOS at RAL, UK. The spacecraft and ground segment operations are performed by the DSP Operations and Management Centre (DOMC and DSOC in China, using three ground station, in Beijing, Shanghai and Villafranca.

  4. Mission Management Computer and Sequencing Hardware for RLV-TD HEX-01 Mission

    Science.gov (United States)

    Gupta, Sukrat; Raj, Remya; Mathew, Asha Mary; Koshy, Anna Priya; Paramasivam, R.; Mookiah, T.

    2017-12-01

    Reusable Launch Vehicle-Technology Demonstrator Hypersonic Experiment (RLV-TD HEX-01) mission posed some unique challenges in the design and development of avionics hardware. This work presents the details of mission critical avionics hardware mainly Mission Management Computer (MMC) and sequencing hardware. The Navigation, Guidance and Control (NGC) chain for RLV-TD is dual redundant with cross-strapped Remote Terminals (RTs) interfaced through MIL-STD-1553B bus. MMC is Bus Controller on the 1553 bus, which does the function of GPS aided navigation, guidance, digital autopilot and sequencing for the RLV-TD launch vehicle in different periodicities (10, 20, 500 ms). Digital autopilot execution in MMC with a periodicity of 10 ms (in ascent phase) is introduced for the first time and successfully demonstrated in the flight. MMC is built around Intel i960 processor and has inbuilt fault tolerance features like ECC for memories. Fault Detection and Isolation schemes are implemented to isolate the failed MMC. The sequencing hardware comprises Stage Processing System (SPS) and Command Execution Module (CEM). SPS is `RT' on the 1553 bus which receives the sequencing and control related commands from MMCs and posts to downstream modules after proper error handling for final execution. SPS is designed as a high reliability system by incorporating various fault tolerance and fault detection features. CEM is a relay based module for sequence command execution.

  5. Sentinel-2 Mission status

    Science.gov (United States)

    Hoersch, Bianca; Colin, Olivier; Gascon, Ferran; Arino, Olivier; Spoto, Francois; Marchese, Franco; Krassenburg, Mike; Koetz, Benjamin

    2016-04-01

    Copernicus is a joint initiative of the European Commission (EC) and the European Space Agency (ESA), designed to establish a European capacity for the provision and use of operational monitoring information for environment and security applications. Within the Copernicus programme, ESA is responsible for the development of the Space Component, a fully operational space-based capability to supply earth-observation data to sustain environmental information Services in Europe. The Sentinel missions are Copernicus dedicated Earth Observation missions composing the essential elements of the Space Component. In the global Copernicus framework, they are complemented by other satellites made available by third-parties or by ESA and coordinated in the synergistic system through the Copernicus Data-Access system versus the Copernicus Services. The Copernicus Sentinel-2 mission provides continuity to services relying on multi-spectral high-resolution optical observations over global terrestrial surfaces. Sentinel-2 capitalizes on the technology and the vast experience acquired in Europe and the US to sustain the operational supply of data for services such as forest monitoring, land cover changes detection or natural disasters management. The Sentinel-2 mission offers an unprecedented combination of the following capabilities: ○ Systematic global coverage of land surfaces: from 56°South to 84°North, coastal waters and Mediterranean sea; ○ High revisit: every 5 days at equator under the same viewing conditions with 2 satellites; ○ High spatial resolution: 10m, 20m and 60m; ○ Multi-spectral information with 13 bands in the visible, near infra-red and short wave infra-red part of the spectrum; ○ Wide field of view: 290 km. The data from the Sentinel-2 mission are available openly and freely for all users with online easy access since December 2015. The presentation will give a status report on the Sentinel-2 mission, and outlook for the remaining ramp-up Phase, the

  6. Complex Biological Systems Analysis of Cell Cycling Models in Carcinogenesis: I. The essential roles of modifications in the c-Myc, TP53/p53, p27 and hTERT modules in Cancer Initiation and Progression

    CERN Document Server

    Prisecaru, V I

    2004-01-01

    A new approach to the integration of results from a modular, complex biological systems analysis of nonlinear dynamics in cell cycling network transformations that are leading to carcinogenesis is proposed. Carcinogenesis is a complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter-related pathways referred to as networks. One such network module contains the cell cyclins whose functions are essential to cell cycling and division. Cyclins are proteins that also link to several critical pro-apoptotic and other cell cycling/division components, such as: c-Myc, p27, the tumor suppressor gene TP53 and its product-- the p53 protein with key roles in controlling DNA repair, inducing apoptosis and activating p21 (which can depress cell cyclins if activated), mdm2(with its biosynthesis activated by p53 and also, in its turn, inhibiting p53), p21, the Thomsen-Friedenreich antigen(T- antigen),Rb,Bax, Ba...

  7. The THEMIS Mission

    CERN Document Server

    Burch, J. L

    2009-01-01

    The THEMIS mission aims to determine the trigger and large-scale evolution of substorms by employing five identical micro-satellites which line up along the Earth's magnetotail to track the motion of particles, plasma, and waves from one point to another and for the first time, resolve space-time ambiguities in key regions of the magnetosphere on a global scale. The primary goal of THEMIS is to elucidate which magnetotail process is responsible for substorm onset at the region where substorm auroras map: (i) local disruption of the plasma sheet current (current disruption) or (ii) the interaction of the current sheet with the rapid influx of plasma emanating from reconnection. The probes also traverse the radiation belts and the dayside magnetosphere, allowing THEMIS to address additional baseline objectives. This volume describes the mission, the instrumentation, and the data derived from them.

  8. Lynx mission concept study

    Science.gov (United States)

    Vikhlinin, Alexey

    2018-01-01

    Lynx is an observatory-class mission, featuring high throughput, exquisite angular resolution over a substantial field of view, and high spectral resolution for point and extended X-ray sources. The design requirements provide a tremendous leap in capabilities relative to missions such as Chandra and Athena. Lynx will observe the dawn of supermassive black holes through detection of very faint X-ray sources in the early universe and will reveal the "invisible drivers" of galaxy and structure formation through observations of hot, diffuse baryons in and around the galaxies. Lynx will enable breakthroughs across all of astrophysics, ranging from detailed understanding of stellar activity including effects on habitability of associated planets to population statistics of neutron stars and black holes in the Local Group galaxies, to earliest groups and clusters of galaxies, and to cosmology

  9. Spacelab Life Sciences 1 - Dedicated life sciences mission

    Science.gov (United States)

    Womack, W. D.

    1990-01-01

    The Spacelab Life Sciences 1 (SLS-1) mission is discussed, and an overview of the SLS-1 Spacelab configuration is shown. Twenty interdisciplinary experiments, planned for this mission, are intended to explore the early stages of human and animal physiological adaptation to space flight conditions. Biomedical and gravitational biology experiments include cardiovascular and cardiopulmonary deconditioning, altered vestibular functions, altered metabolic functions (including altered fluid-electrolyte regulation), muscle atrophy, bone demineralization, decreased red blood cell mass, and altered immunologic responses.

  10. Mission as Metaphor: Reconceptualizing How Leaders Utilize Institutional Mission

    Science.gov (United States)

    Zenk, Leslie R.; Seashore Louis, Karen R.

    2018-01-01

    Background/Context: Institutional missions serve many purposes within universities, but most studies focus on how mission points to direction, guidelines, or priorities. However, organizational missions have been shown to have other functions such as instructing members about actions or behaviors that are acceptable. This paper therefore examines…

  11. The INTEGRAL mission

    DEFF Research Database (Denmark)

    Winkler, C.; Courvoisier, T.J.L.; Di Cocco, G.

    2003-01-01

    -angular resolution imaging (15 keV-10 MeV). Two monitors, JEM-X (Lund et al. 2003) in the (3-35) keV X-ray band, and OMC (Mas-Hesse et al. 2003) in optical Johnson V-band complement the payload. The ground segment includes the Mission Operations Centre at ESOC, ESA and NASA ground stations, the Science Operations...

  12. Asteroid Kinetic Impactor Missions

    Science.gov (United States)

    Chesley, Steven

    2015-08-01

    Asteroid impact missions can be carried out as a relatively low-cost add-ons to most asteroid rendezvous missions and such impact experiments have tremendous potential, both scientifically and in the arena of planetary defense.The science returns from an impactor demonstration begin with the documentation of the global effects of the impact, such as changes in orbit and rotation state, the creation and dissipation of an ejecta plume and debris disk, and morphological changes across the body due to the transmission of seismic waves, which might induce landslides and toppling of boulders, etc. At a local level, an inspection of the impact crater and ejecta blanket reveals critical material strength information, as well as spectral differences between the surface and subsurface material.From the planetary defense perspective, an impact demonstration will prove humankind’s capacity to alter the orbit of a potentially threatening asteroid. This technological leap comes in two parts. First, terminal guidance systems that can deliver an impactor with small errors relative to the ~100-200 meter size of a likely impactor have yet to be demonstrated in a deep space environment. Second, the response of an asteroid to such an impact is only understood theoretically due to the potentially significant dependence on the momentum carried by escaping ejecta, which would tend to enhance the deflection by tens of percent and perhaps as much as a factor of a few. A lack of validated understanding of momentum enhancement is a significant obstacle in properly sizing a real-world impactor deflection mission.This presentation will describe the drivers for asteroid impact demonstrations and cover the range of such concepts, starting with ESA’s pioneering Don Quijote mission concept and leading to a brief description of concepts under study at the present time, including the OSIRIS-REx/ISIS, BASiX/KIX and AIM/DART (AIDA) concepts.

  13. Heat Capacity Mapping Mission

    Science.gov (United States)

    Nilsson, C. S.; Andrews, J. C.; Scully-Power, P.; Ball, S.; Speechley, G.; Latham, A. R. (Principal Investigator)

    1980-01-01

    The Tasman Front was delineated by airborne expendable bathythermograph survey; and an Heat Capacity Mapping Mission (HCMM) IR image on the same day shows the same principal features as determined from ground-truth. It is clear that digital enhancement of HCMM images is necessary to map ocean surface temperatures and when done, the Tasman Front and other oceanographic features can be mapped by this method, even through considerable scattered cloud cover.

  14. Cyber Network Mission Dependencies

    Science.gov (United States)

    2015-09-18

    May Also Like” (YMAL) features of popular services like Amazon and Netflix . A mockup interface is shown in Figure 6. A supply agent would enter the...without causing serious harm to the execution of the mission. This idea is based on the technology of the Simian Army, implemented by Netflix and used...very successfully both there and at Amazon [15]. The Netflix Simian Army is designed to force developers to create resilient and robust software

  15. Dawn Mission Update

    Science.gov (United States)

    Sykes, M. V.; Russell, C. T.; Coradini, A.; Christensen, U.; de Sanctis, M. C.; Feldman, W. C.; Jaumann, R.; Keller, U.; Konopliv, A. S.; McCord, T. B.; McFadden, L. A.; McSween, H. Y.; Mottola, S.; Neukum, G.; Pieters, C. M.; Prettyman, T. H.; Raymond, C. A.; Smith, D. E.; Williams, B. G.; Wise, J.; Zuber, M. T.

    2004-11-01

    Dawn, the ninth Discovery mission, will be the first spacecraft to rendezvous with two solar system bodies, the main belt asteroids Vesta and Ceres. This is made possible by utilizing ion propulsion to reach its targets and to maneuver into (and depart) orbits about these bodies. Vesta and Ceres are two terrestrial protoplanets that have survived since the earliest epoch of the solar system and will provide important insights into planet building processes and their evolution under very different circumstances, with and without water. Dawn carries a double framing camera, a visible and infrared mapping spectrometer, and a gamma ray and neutron detector. At Vesta our studies will include the volcanic emplacement of basalts, its differentiation, the possible exposure of its interior near the south pole. At Ceres our studies will include the role of water in its evolution, hydration processes on its surface, and the possible existence of a subsurface ocean. The mission has passed its critical design review and is scheduled to be launched in June 2006 with arrival at Vesta in 2011 and Ceres in 2015. Operation strategies will be presented. Groundbased observations of Vesta, Ceres, and Vesta family members over broad wavelengths, periods and phases will play an important role in detailed mission planning.

  16. Bion-11 Spaceflight Mission

    Science.gov (United States)

    Skidmore, M.

    1999-01-01

    The Sensors 2000! Program, in support of the Space Life Sciences Payloads Office at NASA Ames Research Center developed a suite of bioinstrumentation hardware for use on the Joint US/Russian Bion I I Biosatellite Mission (December 24, 1996 - January 7, 1997). This spaceflight included 20 separate experiments that were organized into a complimentary and interrelated whole, and performed by teams of US, Russian, and French investigators. Over 40 separate parameters were recorded in-flight on both analog and digital recording media for later analysis. These parameters included; Electromyogram (7 ch), Electrogastrogram, Electrooculogram (2 ch), ECG/EKG, Electroencephlogram (2 ch), single fiber firing of Neurovestibular afferent nerves (7 ch), Tendon Force, Head Motion Velocity (pitch & yaw), P02 (in vivo & ambient), temperature (deep body, skin, & ambient), and multiple animal and spacecraft performance parameters for a total of 45 channels of recorded data. Building on the close cooperation of previous missions, US and Russian engineers jointly developed, integrated, and tested the physiologic instrumentation and data recording system. For the first time US developed hardware replaced elements of the Russian systems resulting in a US/Russian hybrid instrumentation and data system that functioned flawlessly during the 14 day mission.

  17. The Spartan 1 mission

    Science.gov (United States)

    Cruddace, Raymond G.; Fritz, G. G.; Shrewsberry, D. J.; Brandenstein, D. J.; Creighton, D. C.; Gutschewski, G.; Lucid, S. W.; Nagel, J. M.; Fabian, J. M.; Zimmerman, D.

    1989-01-01

    The first Spartan mission is documented. The Spartan program, an outgrowth of a joint Naval Research Laboratory (NRL)/National Aeronautics and Space Administration (NASA)-Goddard Space Flight Center (GSFC) development effort, was instituted by NASA for launching autonomous, recoverable payloads from the space shuttle. These payloads have a precise pointing system and are intended to support a wide range of space-science observations and experiments. The first Spartan, carrying an NRL X-ray astronomy instrument, was launched by the orbiter Discovery (STS51G) on June 20, 1985 and recovered successfully 45 h later, on June 22. During this period, Spartan 1 conducted a preprogrammed series of observations of two X-ray sources: the Perseus cluster of galaxies and the center of our galaxy. The mission was successful from both on engineering and a scientific viewpoint. Only one problem was encountered, the attitude control system (ACS) shut down earlier than planned because of high attitude control system gas consumption. A preplanned emergency mode then placed Spartan 1 into a stable, safe condition and allowed a safe recovery. The events are described of the mission and presents X-ray maps of the two observed sources, which were produced from the flight data.

  18. Nanosatellite missions - the future

    Science.gov (United States)

    Koudelka, O.; Kuschnig, R.; Wenger, M.; Romano, P.

    2017-09-01

    In the beginning, nanosatellite projects were focused on educational aspects. In the meantime, the technology matured and now allows to test, demonstrate and validate new systems, operational procedures and services in space at low cost and within much shorter timescales than traditional space endeavors. The number of spacecraft developed and launched has been increasing exponentially in the last years. The constellation of BRITE nanosatellites is demonstrating impressively that demanding scientific requirements can be met with small, low-cost satellites. Industry and space agencies are now embracing small satellite technology. Particularly in the USA, companies have been established to provide commercial services based on CubeSats. The approach is in general different from traditional space projects with their strict product/quality assurance and documentation requirements. The paper gives an overview of nanosatellite missions in different areas of application. Based on lessons learnt from the BRITE mission and recent developments at TU Graz (in particular the implementation of the OPS-SAT nanosatellite for ESA), enhanced technical possibilities for a future astronomy mission after BRITE will be discussed. Powerful on-board computers will allow on-board data pre-processing. A state-of-the-art telemetry system with high data rates would facilitate interference-free operations and increase science data return.

  19. Landsat Data Continuity Mission

    Science.gov (United States)

    ,

    2012-01-01

    The Landsat Data Continuity Mission (LDCM) is a partnership formed between the National Aeronautics and Space Administration (NASA) and the U.S. Geological Survey (USGS) to place the next Landsat satellite in orbit in January 2013. The Landsat era that began in 1972 will become a nearly 41-year global land record with the successful launch and operation of the LDCM. The LDCM will continue the acquisition, archiving, and distribution of multispectral imagery affording global, synoptic, and repetitive coverage of the Earth's land surfaces at a scale where natural and human-induced changes can be detected, differentiated, characterized, and monitored over time. The mission objectives of the LDCM are to (1) collect and archive medium resolution (30-meter spatial resolution) multispectral image data affording seasonal coverage of the global landmasses for a period of no less than 5 years; (2) ensure that LDCM data are sufficiently consistent with data from the earlier Landsat missions in terms of acquisition geometry, calibration, coverage characteristics, spectral characteristics, output product quality, and data availability to permit studies of landcover and land-use change over time; and (3) distribute LDCM data products to the general public on a nondiscriminatory basis at no cost to the user.

  20. A seismic-network mission proposal as an example for modular robotic lunar exploration missions

    Science.gov (United States)

    Lange, C.; Witte, L.; Rosta, R.; Sohl, F.; Heffels, A.; Knapmeyer, M.

    2017-05-01

    In this paper it is intended to discuss an approach to reduce design costs for subsequent missions by introducing modularity, commonality and multi-mission capability and thereby reuse of mission individual investments into the design of lunar exploration infrastructural systems. The presented approach has been developed within the German Helmholtz-Alliance on Robotic Exploration of Extreme Environments (ROBEX), a research alliance bringing together deep-sea and space research to jointly develop technologies and investigate problems for the exploration of highly inaccessible terrain - be it in the deep sea and polar regions or on the Moon and other planets. Although overall costs are much smaller for deep sea missions as compared to lunar missions, a lot can be learned from modularity approaches in deep sea research infrastructure design, which allows a high operational flexibility in the planning phase of a mission as well as during its implementation. The research presented here is based on a review of existing modular solutions in Earth orbiting satellites as well as science and exploration systems. This is followed by an investigation of lunar exploration scenarios from which we derive requirements for a multi-mission modular architecture. After analyzing possible options, an approach using a bus modular architecture for dedicated subsystems is presented. The approach is based on exchangeable modules e.g. incorporating instruments, which are added to the baseline system platform according to the demands of the specific scenario. It will be described in more detail, including arising problems e.g. in the power or thermal domain. Finally, technological building blocks to put the architecture into practical use will be described more in detail.

  1. Planning to fail: mission design for modular repairable robot teams

    Science.gov (United States)

    Stancliff, Stephen B.; Dolan, John B.; Trebi-Ollennu, Ashitey

    2005-01-01

    This paper presents a method using stochastic simulation to evaluate the reliability of robot teams consisting of modular robots. For an example planetary exploration mission we use this method to compare the performance of a repairable robot team with spare modules versus nonrepairable robot teams.

  2. Instrument demonstration effort for the CLARREO mission

    Science.gov (United States)

    Grandmont, Frédéric; Moreau, Louis; Bourque, Hugo; Taylor, Joe; Girard, Frédéric; Larouche, Martin; Veilleux, James

    2017-11-01

    the DS conclusion, and considering the early development stage of the mission, NASA funded three Instrument Incubator Programs (IIP) to push instrument concepts to a higher level of maturity. A joint proposal between University of Wisconsin (UW) and Harvard University was selected to address the first above objective and part of the fourth one in the corresponding spectral region. In order to achieve this goal, four complementary technologies are to be developed [2]: (1) On-orbit Absolute Radiance Standard (OARS), a high emissivity blackbody source that uses multiple miniature phase-change cells to provide a revolutionary on-orbit standard with absolute temperature accuracy proven over a wide range of temperatures. (2) On-orbit Cavity Emissivity Modules (OCEMs), providing a source (quantum cascade laser, QCL, or "Heated Halo") to measure any change in the cavity emissivity of the OARS. (3) On-orbit Spectral Response Module (OSRM), a source for spectral response measurements using a nearly monochromatic QCL source configured to uniformly fill the sensor field-of-view. (4) Dual Absolute Radiance Interferometers (DARI), providing spectral coverage from 3.3 to 50 μm that can be inter-compared to dissect any unexpected systematic errors in overlapping spectral regions. ABB's GFI (Generic Flight Interferometer) has been selected as the favoured architecture for the DARI, mainly due to the maturity of the design and its space heritage. A GFI with commercial grade components was optimised for the selected spectral range. The architecture of the GFI will ensure a high response stability between calibrations.

  3. TCSP MISSION REPORTS V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The TCSP Mission Reports were filed every day that an aircraft flew in support of the experiment. The reports include a short description of the day's mission, its...

  4. Mission Critical Occupation (MCO) Charts

    Data.gov (United States)

    Office of Personnel Management — Agencies report resource data and targets for government-wide mission critical occupations and agency specific mission critical and/or high risk occupations. These...

  5. Operational Lessons Learned from NASA Analog Missions

    Science.gov (United States)

    Arnold, Larissa S.

    2010-01-01

    vehicle and system capabilities are required to support the activities? How will the crew and the Earth-based mission control team interact? During the initial phases of manned planetary exploration, one challenge in particular is virtually the same as during the Apollo program: How can scientific return be maximized during a relatively short surface mission? Today, NASA is investigating solutions to these challenges by conducting analog missions. These Earth-based missions possess characteristics that are analogous to missions on the Moon or Mars. These missions are excellent for testing operational concepts, and the design, configuration, and functionality of spacesuits, robots, rovers, and habitats. Analog mission crews test specific techniques and procedures for surface field geology, biological sample collection, and planetary protection. The process of actually working an analog mission reveals a myriad of small details, which either contribute to or impede efficient operations, many of which would never have been thought about otherwise. It also helps to define the suite of tools, containers, and other small equipment that surface explorers will use. This paper focuses on how analog missions have addressed selected operational considerations for future planetary missions.

  6. Crossing Boundaries in Undergraduate Biology Education

    Science.gov (United States)

    Vanderklein, Dirk; Munakata, Mika; McManus, Jason

    2016-01-01

    In an effort to make mathematics relevant to biology students, the authors developed two modules that sought to integrate mathematics and ecology instruction to differing degrees. The modules were developed by a team of biology and mathematics educators and were implemented in an ecology course using three different instructional methods for three…

  7. Towards Logical Designs In Biology

    Indian Academy of Sciences (India)

    Towards Logical Designs in Biology. Garima Agarwal. General Article Volume 12 Issue 2 February 2007 pp 29-38. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/012/02/0029-0038. Keywords. Synthetic biology; logic gates; regulatory modules; gene circuits. Author Affiliations.

  8. Phobos-Grunt Mission: Planetary Protection Issues and how to Solve Them (the Approaches Based on the Exobiological Experiments Results)

    Science.gov (United States)

    Novikova, Nataliya; Orlov, Oleg; Deshevaya, Elena; Sychev, Vladimir; Khamidullina, N.; Aleksashkin, Sergey; Martynov, Maxim

    The launch of a Russian spaceship to Phobos is being planned in 2011 as a part of the project "Phobos-Soil". Major goals of the mission are: -Landing of the orbital vehicle (transport module) on the Phobos surface, collecting soil samples for delivery to Earth in a sealed inde-structible container; -Some experiments, including exobiological experiment aimed to evaluate viability of dormant organisms-representatives of a variety of taxonomic groups after extended interplanetary trip. According to COSPAR classification the orbital Mars spaceship flight is related to the category III and the mission of Phobos soil delivery to the Earth in a capsule on a descent vehicle is related to the category V to which any missions of return to the Earth are related. In order to supply Mars and Earth protection a number of actions is worked out: -The probability of space craft destruction and its falling down on the Mars surface is limited, and that is proved by the calculations; -The proposals to break the "chain of contact" with Earth of equipment used on the Phobos surface; -Preservation of tightness of the containers with Phobos soil and biological samples should be provided at all the stages of the mission up to the landing onto the Earth; -Phobos soil and biological samples delivery to specialized organiza-tion licensed to carry out works with highly dangerous microorganisms should be organized. So severe measures of the planet protection are based not only on the COSPAR demands, but also on the results of the Russian exobiological experiments, which proved that ability of survival in outer space was shown experimentally not only for spores of bacteria and microscopic fungi, but also for resting stages of higher organisms.

  9. A Survey of Cost Estimating Methodologies for Distributed Spacecraft Missions

    Science.gov (United States)

    Foreman, Veronica L.; Le Moigne, Jacqueline; de Weck, Oliver L.

    2016-01-01

    Satellite constellations and Distributed Spacecraft Mission (DSM) architectures offer unique benefits to Earth observation scientists and unique challenges to cost estimators. The Cost and Risk (CR) module of the Tradespace Analysis Tool for Constellations (TAT-C) being developed by NASA Goddard seeks to address some of these challenges by providing a new approach to cost modeling, which aggregates existing Cost Estimating Relationships (CER) from respected sources, cost estimating best practices, and data from existing and proposed satellite designs. Cost estimation through this tool is approached from two perspectives: parametric cost estimating relationships and analogous cost estimation techniques. The dual approach utilized within the TAT-C CR module is intended to address prevailing concerns regarding early design stage cost estimates, and offer increased transparency and fidelity by offering two preliminary perspectives on mission cost. This work outlines the existing cost model, details assumptions built into the model, and explains what measures have been taken to address the particular challenges of constellation cost estimating. The risk estimation portion of the TAT-C CR module is still in development and will be presented in future work. The cost estimate produced by the CR module is not intended to be an exact mission valuation, but rather a comparative tool to assist in the exploration of the constellation design tradespace. Previous work has noted that estimating the cost of satellite constellations is difficult given that no comprehensive model for constellation cost estimation has yet been developed, and as such, quantitative assessment of multiple spacecraft missions has many remaining areas of uncertainty. By incorporating well-established CERs with preliminary approaches to approaching these uncertainties, the CR module offers more complete approach to constellation costing than has previously been available to mission architects or Earth

  10. SOFIA mission operations

    Science.gov (United States)

    Waddell, Patrick G.; Davidson, Jacqueline A.

    2002-02-01

    The SOFIA Airborne Observatory will operate a 2.5 m aperture telescope with the goal of obtaining over 960 successful science hours per year at a nominal altitude of 12.5 km and covering a wavelength range from 0.3 mm to 1.6 mm. The observatory platform is comprised of a Boeing 747SP with numerous significant modifications. The ground and flight mission operations architectures and plans are tailored to keep the telescope emissivity low and achieve high observing efficiency.

  11. The ARTEMIS mission

    CERN Document Server

    Angelopoulos, Vassilis

    2014-01-01

    The ARTEMIS mission was initiated by skillfully moving the two outermost Earth-orbiting THEMIS spacecraft into lunar orbit to conduct unprecedented dual spacecraft observations of the lunar environment. ARTEMIS stands for Acceleration, Reconnection, Turbulence and Electrodynamics of the Moon's Interaction with the Sun. Indeed, this volume discusses initial findings related to the Moon’s magnetic and plasma environments and the electrical conductivity of the lunar interior. This work is aimed at researchers and graduate students in both heliophysics and planetary physics. Originally published in Space Science Reviews, Vol. 165/1-4, 2011.

  12. Mission to Planet Earth

    Science.gov (United States)

    Tilford, Shelby G.; Asrar, Ghassem; Backlund, Peter W.

    1994-01-01

    Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the Earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic Earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the Earth and how it works as a system. Increased understanding of the Earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment.

  13. Mission to Planet Earth

    International Nuclear Information System (INIS)

    Wilson, G.S.; Backlund, P.W.

    1992-01-01

    Mission to Planet Earth (MTPE) is NASA's concept for an international science program to produce the understanding needed to predict changes in the earth's environment. NASA and its interagency and international partners will place satellites carrying advanced sensors in strategic earth orbits to gather multidisciplinary data. A sophisticated data system will process and archive an unprecedented amount of information about the earth and how it works as a system. Increased understanding of the earth system is a basic human responsibility, a prerequisite to informed management of the planet's resources and to the preservation of the global environment. 8 refs

  14. Personality and Mission Effectiveness

    Science.gov (United States)

    2006-10-01

    7Ej5j/ IPIP /ipipneo300.htm  The full IPIP contains 1,699 items assembled by Dr. Lewis R. Goldberg. The URL for Dr. Goldberg’s IPIP is http...ipip.ori.org/ . The IPIP is in the public domain and its items can be freely downloaded from that site.  The IPIP -NEO is not equivalent to the...Differences  ~ Mission Statement ~  This IPIP Website is intended to provide rapid access to measures of individual differences, all in the

  15. Verification and Implementation of Operations Safety Controls for Flight Missions

    Science.gov (United States)

    Jones, Cheryl L.; Smalls, James R.; Carrier, Alicia S.

    2010-01-01

    Approximately eleven years ago, the International Space Station launched the first module from Russia, the Functional Cargo Block (FGB). Safety and Mission Assurance (S&MA) Operations (Ops) Engineers played an integral part in that endeavor by executing strict flight product verification as well as continued staffing of S&MA's console in the Mission Evaluation Room (MER) for that flight mission. How were these engineers able to conduct such a complicated task? They conducted it based on product verification that consisted of ensuring that safety requirements were adequately contained in all flight products that affected crew safety. S&MA Ops engineers apply both systems engineering and project management principles in order to gain a appropriate level of technical knowledge necessary to perform thorough reviews which cover the subsystem(s) affected. They also ensured that mission priorities were carried out with a great detail and success.

  16. MONTE: the next generation of mission design and navigation software

    Science.gov (United States)

    Evans, Scott; Taber, William; Drain, Theodore; Smith, Jonathon; Wu, Hsi-Cheng; Guevara, Michelle; Sunseri, Richard; Evans, James

    2018-03-01

    The Mission analysis, Operations and Navigation Toolkit Environment (MONTE) (Sunseri et al. in NASA Tech Briefs 36(9), 2012) is an astrodynamic toolkit produced by the Mission Design and Navigation Software Group at the Jet Propulsion Laboratory. It provides a single integrated environment for all phases of deep space and Earth orbiting missions. Capabilities include: trajectory optimization and analysis, operational orbit determination, flight path control, and 2D/3D visualization. MONTE is presented to the user as an importable Python language module. This allows a simple but powerful user interface via CLUI or script. In addition, the Python interface allows MONTE to be used seamlessly with other canonical scientific programming tools such as SciPy, NumPy, and Matplotlib. MONTE is the prime operational orbit determination software for all JPL navigated missions.

  17. MONTE: the next generation of mission design and navigation software

    Science.gov (United States)

    Evans, Scott; Taber, William; Drain, Theodore; Smith, Jonathon; Wu, Hsi-Cheng; Guevara, Michelle; Sunseri, Richard; Evans, James

    2018-01-01

    The Mission analysis, Operations and Navigation Toolkit Environment (MONTE) (Sunseri et al. in NASA Tech Briefs 36(9), 2012) is an astrodynamic toolkit produced by the Mission Design and Navigation Software Group at the Jet Propulsion Laboratory. It provides a single integrated environment for all phases of deep space and Earth orbiting missions. Capabilities include: trajectory optimization and analysis, operational orbit determination, flight path control, and 2D/3D visualization. MONTE is presented to the user as an importable Python language module. This allows a simple but powerful user interface via CLUI or script. In addition, the Python interface allows MONTE to be used seamlessly with other canonical scientific programming tools such as SciPy, NumPy, and Matplotlib. MONTE is the prime operational orbit determination software for all JPL navigated missions.

  18. CADDIS Volume 4. Data Analysis: Predicting Environmental Conditions from Biological Observations (PECBO Appendix)

    Science.gov (United States)

    Overview of PECBO Module, using scripts to infer environmental conditions from biological observations, statistically estimating species-environment relationships, methods for inferring environmental conditions, statistical scripts in module.

  19. Calvin and mission

    Directory of Open Access Journals (Sweden)

    Jacobus (Kobus P. Labuschagne

    2009-11-01

    Full Text Available It has often been stated or implied that John Calvin and the Reformers in general were indifferent to or even against mission. The aim of this study is to point out that this understanding is not a true version of the facts. A thorough examination of the theology and actions of John Calvin, evaluated against the background of his times and world, reveals that he was firmly committed to spreading the Gospel of Jesus Christ, the Lord. Also the theological insights of Calvin and the Reformers not only provided the crucial theological basis to support the future massive missionary expansion of Protestant churches, but necessitate for all times Church mission as a sure consequence of their theology. Calvin’s theology can indeed be described as an ‘essentially missionary theology’. In the heart of Calvin’s theological thinking clearly features the doctrine of justifi cation – because medieval man’s concern for salvation needed to be answered.

  20. The DUAL mission concept

    Science.gov (United States)

    von Ballmoos, Peter; Alvarez, Jose; Barriere, Nicolas; Boggs, Steve; Bykov, Andrei; Del Cura Velayos, Juan Manuel; Frontera, Filippo; Hanlon, Lorraine; Hernanz, Margarita; Hinglais, Emmanuel; Isern, Jordi; Jean, Pierre; Knödlseder, Jürgen; Kuiper, Lucien; Leising, Mark; Pirard, Benoît; Prost, Jean-Pierre; da Silva, Rui; Takahashi, Tadayuki; Tomsick, John; Walter, Roland; Zoglauer, Andreas

    2011-09-01

    DUAL will study the origin and evolution of the elements and explores new frontiers of physics: extreme energies that drive powerful stellar explosions and accelerate particles to macroscopic energies; extreme densities that modify the laws of physics around the most compact objects known; and extreme fields that influence matter in a way that is unknown on Earth. The variability of these extreme objects requires continuous all-sky coverage, while detailed study demands an improvement in sensitivity over previous technologies by at least an order of magnitude. The DUAL payload is composed of an All-Sky Compton Imager (ASCI), and two optical modules, the Laue-Lens Optic (LLO) and the Coded-Mask Optic (CMO). The ASCI serves dual roles simultaneously, both as an optimal focal-plane sensor for deep observations with the optical modules and as a sensitive true all-sky telescope in its own right for all-sky surveys and monitoring. While the optical modules are located on the main satellite, the All-Sky Compton Imager is situated on a deployable structure at a distance of 30 m from the satellite. This configuration not only permits to maintain the less massive payload at the focal distance, it also greatly reduces the spacecraft-induced detector background, and, above all it provides ASCI with a continuous all-sky exposure.

  1. STS-78 Mission Insignia

    Science.gov (United States)

    1996-01-01

    The STS-78 patch links past with present to tell the story of its mission and science through a design imbued with the strength and vitality of the 2-dimensional art of North America's northwest coast Indians. Central to the design is the space Shuttle whose bold lines and curves evoke the Indian image for the eagle, a native American symbol of power and prestige as well as the national symbol of the United States. The wings of the Shuttle suggest the wings of the eagle whose feathers, indicative of peace and friendship in Indian tradition, are captured by the U forms, a characteristic feature of Northwest coast Indian art. The nose of the Shuttle is the strong downward curve of the eagle's beak, and the Shuttle's forward windows, the eagle's eyes, represented through the tapered S forms again typical of this Indian art form. The basic black and red atoms orbiting the mission number recall the original NASA emblem while beneath, utilizing Indian ovoid forms, the major mission scientific experiment package LMS (Life and Materials Sciences) housed in the Shuttle's cargo bay is depicted in a manner reminiscent of totem-pole art. This image of a bird poised for flight, so common to Indian art, is counterpointed by an equally familiar Tsimshian Indian symbol, a pulsating sun with long hyperbolic rays, the symbol of life. Within each of these rays are now encased crystals, the products of this mission's 3 major, high-temperature materials processing furnaces. And as the sky in Indian lore is a lovely open country, home of the Sun Chief and accessible to travelers through a hole in the western horizon, so too, space is a vast and beckoning landscape for explorers launched beyond the horizon. Beneath the Tsimshian sun, the colors of the earth limb are appropriately enclosed by a red border representing life to the Northwest coast Indians. The Indian colors of red, navy blue, white, and black pervade the STS-78 path. To the right of the Shuttle-eagle, the constellation

  2. Development of a New Radiation Sensor for Satellite Missions

    Science.gov (United States)

    Ritter, Birgit; Berger, Thomas; Reitz, Guenther; Hauslage, Jens; Marsalek, Karel; Aeckerlein, Joachim; M, Hartmut

    The RAMIS (RAdiation Measurements In Space) experiment aims to measure cosmic radiation with energy deposition ranging from minimal ionizing protons up to relativistic iron nuclei. The radiation detector principle uses two silicon detectors, each with an active area of 0.5cm² that are arranged in a telescope configuration. The experiment will fly in 2016 on the first mission of the newly developed DLR (German Aerospace Center) Compact Satellite, which intends to provide an easy accessible platform for scientific research within DLR as well as for international partners and their experiments. As the satellite will orbit Earth at an altitude of about 600 km on a polar orbit, valuable insights are gained not only in the galactic cosmic ray (GCR) component of the radiation field and in solar energetic particles (SEPs) in case of solar events. Also the trapped radiation in the horns of the electron belts around Earth can be studied in detail. Particle fluxes will be monitored and energy deposition spectra recorded from which linear energy transfer spectra will be generated. These spectra give an estimate for the quality of the radiation field. The RAMIS experiment consists of two modules, i.e. two small silicon detector telescopes, with one module being located outside on top of the satellite, while the other one is placed inside next to the primary payload of the satellite, the Eu:CROPIS experiment. Eu:CROPIS is a combined self-sustained biological life support system under Moon and Mars gravity, which uses Euglena as oxygen suppliers, biofilter for wastewater treatment and detoxification, and urine as primary fertilizer. In addition to its scientific output RAMIS will provide dosimetric monitoring for Eu:CROPIS and serve as a radiation exposure information system for the satellite bus. Furthermore the obtained data can be used for benchmarking and improvement of radiation belt models as well as of shielding models by combining the results of both modules. The RAMIS

  3. Spatial Terahertz Modulator

    Science.gov (United States)

    Xie, Zhenwei; Wang, Xinke; Ye, Jiasheng; Feng, Shengfei; Sun, Wenfeng; Akalin, Tahsin; Zhang, Yan

    2013-11-01

    Terahertz (THz) technology is a developing and promising candidate for biological imaging, security inspection and communications, due to the low photon energy, the high transparency and the broad band properties of the THz radiation. However, a major encountered bottleneck is lack of efficient devices to manipulate the THz wave, especially to modulate the THz wave front. A wave front modulator should allow the optical or electrical control of the spatial transmission (or reflection) of an input THz wave and hence the ability to encode the information in a wave front. Here we propose a spatial THz modulator (STM) to dynamically control the THz wave front with photo-generated carriers. A computer generated THz hologram is projected onto a silicon wafer by a conventional spatial light modulator (SLM). The corresponding photo-generated carrier spatial distribution will be induced, which forms an amplitude hologram to modulate the wave front of the input THz beam. Some special intensity patterns and vortex beams are generated by using this method. This all-optical controllable STM is structure free, high resolution and broadband. It is expected to be widely used in future THz imaging and communication systems.

  4. SCATHA mission termination report

    Science.gov (United States)

    Stakkestad, Kjell; Fennessey, Richard

    1993-02-01

    The SCATHA (Spacecraft Charging at High Altitudes) satellite was operated from the Consolidated Space Test Center in Sunnyvale, California from February 1979 to May 1991. It was a spin stabilized vehicle in a highly eccentric orbit that collected data on spacecraft charging. The purpose of such data gathering was to predict and/or model the effects of the Earth's magnetic field on synchronous and near synchronous satellites. During the majority of its lifetime, attitude precession maneuvers were done every 10-15 days to maintain solar panel orientation. Maneuver planning was difficult due to the structural characteristics of SCATHA. It is cylindrically shaped and has seven booms ranging in length from 2 to 50 meters. These precession maneuvers induced predictable nutation that damped out after a few days. Eventually fuel began running low due to these frequent maneuvers. Experiments that had required the spin axis be in the orbit plane had already been turned off or had collected all their data. To increase the vehicle lifetime, the spin axis was moved to ecliptic normal. While this stopped the need for frequent attitude maneuvering (only two per year required now), this movement of the spin axis caused nutation that would not damp out for the remainder of the mission. This phase of the mission, with the ecliptic normal orientation, lasted for approximately three years. Although nutation never damped, data gathering was uninterrupted. In late 1990, when SCATHA's transmitter became seriously degraded, the Air Force decided to turn SCATHA off. This would only be done after the satellite was made 'safe'. The most difficult part of making the vehicle safe was quickly purging the fuel. Several plans were considered. The selected plan was to perform a series of 20 degree attitude precession maneuvers (3 days apart to allow for the worst nutation to damp) until the fuel was depleted. determination software, and an error in the fuel level calculation software. This paper

  5. eXamine: Exploring annotated modules in networks

    NARCIS (Netherlands)

    Dinkla, K.; El-Kebir, M.; Bucur, C.I.; Siderius, M.; Smit, M.J.; Westenberg, M.A.; Klau, G.W.

    2014-01-01

    Background: Biological networks have a growing importance for the interpretation of high-throughput " omics" data. Integrative network analysis makes use of statistical and combinatorial methods to extract smaller subnetwork modules, and performs enrichment analysis to annotate the modules with

  6. STS-73 Mission Insignia

    Science.gov (United States)

    1995-01-01

    The crew patch of STS-73, the second flight of the United States Microgravity Laboratory (USML-2), depicts the Space Shuttle Columbia in the vastness of space. In the foreground are the classic regular polyhedrons that were investigated by Plato and later Euclid. The Pythagoreans were also fascinated by the symmetrical three-dimensional objects whose sides are the same regular polygon. The tetrahedron, the cube, the octahedron, and the icosahedron were each associated with the Natural Elements of that time: fire (on this mission represented as combustion science); Earth (crystallography), air and water (fluid physics). An additional icon shown as the infinity symbol was added to further convey the discipline of fluid mechanics. The shape of the emblem represents a fifth polyhedron, a dodecahedron, which the Pythagoreans thought corresponded to a fifth element that represented the cosmos.

  7. Hayabusa2 Mission Overview

    Science.gov (United States)

    Watanabe, Sei-ichiro; Tsuda, Yuichi; Yoshikawa, Makoto; Tanaka, Satoshi; Saiki, Takanao; Nakazawa, Satoru

    2017-07-01

    The Hayabusa2 mission journeys to C-type near-Earth asteroid (162173) Ryugu (1999 JU3) to observe and explore the 900 m-sized object, as well as return samples collected from the surface layer. The Haybusa2 spacecraft developed by Japan Aerospace Exploration Agency (JAXA) was successfully launched on December 3, 2014 by an H-IIA launch vehicle and performed an Earth swing-by on December 3, 2015 to set it on a course toward its target Ryugu. Hayabusa2 aims at increasing our knowledge of the early history and transfer processes of the solar system through deciphering memories recorded on Ryugu, especially about the origin of water and organic materials transferred to the Earth's region. Hayabusa2 carries four remote-sensing instruments, a telescopic optical camera with seven colors (ONC-T), a laser altimeter (LIDAR), a near-infrared spectrometer covering the 3-μm absorption band (NIRS3), and a thermal infrared imager (TIR). It also has three small rovers of MINERVA-II and a small lander MASCOT (Mobile Asteroid Surface Scout) developed by German Aerospace Center (DLR) in cooperation with French space agency CNES. MASCOT has a wide angle imager (MasCam), a 6-band thermal radiator (MARA), a 3-axis magnetometer (MasMag), and a hyperspectral infrared microscope (MicrOmega). Further, Hayabusa2 has a sampling device (SMP), and impact experiment devices which consist of a small carry-on impactor (SCI) and a deployable camera (DCAM3). The interdisciplinary research using the data from these onboard and lander's instruments and the analyses of returned samples are the key to success of the mission.

  8. The Mars Pathfinder mission

    Science.gov (United States)

    Golombek, Matthew P.

    1997-02-01

    Mars Pathfinder, one of the first Discovery-class missions (quick, low-cost projects with focused science objectives), will land a single spacecraft with a microrover and several instruments on the surface of Mars in 1997. Pathfinder will be the first mission to use a rover, carrying a chemical analysis instrument, to characterize the rocks and soils in a landing area over hundreds of square meters on Mars, which will provide a calibration point or ``ground truth'' for orbital remote sensing observations. In addition to the rover, which also performs a number of technology experiments, Pathfinder carries three science instruments: a stereoscopic imager with spectral filters on an extendable mast, an alpha proton X ray spectrometer, and an atmospheric structure instrument/metereology package. The instruments, the rover technology experiments, and the telemetry system will allow investigations of the surface morphology and geology at submeter to a hundred meters scale, the petrology and geochemistry of rocks and soils, the magnetic properties of dust, soil mechanics and properties, a variety of atmospheric investigations, and the rotational and orbital dynamics of Mars. Landing downstream from the mouth of a giant catastrophic outflow channel, Ares Vallis at 19.5°N, 32.8°W, offers the potential of identifying and analyzing a wide variety of crustal materials, from the ancient heavily cratered terrain, intermediate-aged ridged plains, and reworked channel deposits, thus allowing first-order scientific investigations of the early differentiation and evolution of the crust, the development of weathering products, and the early environments and conditions on Mars.

  9. The Messenger Mission to Mercury

    CERN Document Server

    Domingue, D. L

    2007-01-01

    NASA’s MESSENGER mission, launched on 3 August, 2004 is the seventh mission in the Discovery series. MESSENGER encounters the planet Mercury four times, culminating with an insertion into orbit on 18 March 2011. It carries a comprehensive package of geophysical, geological, geochemical, and space environment experiments to complete the complex investigations of this solar-system end member, which begun with Mariner 10. The articles in this book, written by the experts in each area of the MESSENGER mission, describe the mission, spacecraft, scientific objectives, and payload. The book is of interest to all potential users of the data returned by the MESSENGER mission, to those studying the nature of the planet Mercury, and by all those interested in the design and implementation of planetary exploration missions.

  10. Systems Biology

    Indian Academy of Sciences (India)

    IAS Admin

    Systems biology seeks to study biological systems as a whole, contrary to the reductionist approach that has dominated biology. Such a view of biological systems emanating from strong foundations of molecular level understanding of the individual components in terms of their form, function and interactions is promising to ...

  11. Joint Mission Command Implementation

    Science.gov (United States)

    2016-01-22

    choose. The paper finds that trust is strongly influenced by the subconscious brain and treating it like a tool ignores biology and results in...understanding, intent, and trust, only trust is strongly influenced by the subconscious brain. Treating trust like it can be taught, or a behavior that...practice. Braynov argues that trust is not entirely determined by our mind .48 He describes the “fundamental assumption in economics, game

  12. NASA's Asteroid Redirect Mission (ARM)

    Science.gov (United States)

    Abell, Paul; Mazanek, Dan; Reeves, David; Naasz, Bo; Cichy, Benjamin

    2015-11-01

    The National Aeronautics and Space Administration (NASA) is developing a robotic mission to visit a large near-Earth asteroid (NEA), collect a multi-ton boulder from its surface, and redirect it into a stable orbit around the Moon. Once returned to cislunar space in the mid-2020s, astronauts will explore the boulder and return to Earth with samples. This Asteroid Redirect Mission (ARM) is part of NASA’s plan to advance the technologies, capabilities, and spaceflight experience needed for a human mission to the Martian system in the 2030s. Subsequent human and robotic missions to the asteroidal material would also be facilitated by its return to cislunar space. Although ARM is primarily a capability demonstration mission (i.e., technologies and associated operations), there exist significant opportunities to advance our knowledge of small bodies in the synergistic areas of science, planetary defense, asteroidal resources and in-situ resource utilization (ISRU), and capability and technology demonstrations. In order to maximize the knowledge return from the mission, NASA is organizing an ARM Investigation Team, which is being preceded by the Formulation Assessment and Support Team. These teams will be comprised of scientists, technologists, and other qualified and interested individuals to help plan the implementation and execution of ARM. An overview of robotic and crewed segments of ARM, including the mission requirements, NEA targets, and mission operations, will be provided along with a discussion of the potential opportunities associated with the mission.

  13. Mission to Mars to Collect a Storehouse of Scientific Data

    OpenAIRE

    Albee, Arden

    1996-01-01

    Just after Election Day, the Mars Global Surveyor spacecraft (Figure 1) will embark on a journey to Mars to examine the surface and the seasonal variations of the atmosphere over an entire Mars year. Mars is an extremely rich mission target because the scientific questions it poses touch on geology, geophysics, geochemistry, atmospheric physics, climatology, biology, and—most of all—comparative planetology.

  14. The ``C.E.B.A.S. MINI-MODULE'': A self-sustaining closed aquatic ecosystem for spaceflight experimentation

    Science.gov (United States)

    Blüm, V.; Andriske, M.; Ludwig, Ch.; Paaßen, U.; Voeste, D.

    The C.E.B.A.S. MINI-MODULE is the miniaturized space flight version of the Closed Equilibrated Biological Aquatic System (C.E.B.A.S.). It fits into a large middeck locker tray and is scheduled to be flown in the STS 85 and in the NEUROLAB missions. Its volume is about 9 liters and it consists of two animal tanks, a plant cultivator, and a bacteria filter in a monolithic design. An external sensor unit is connected to a data acquisition/control unit. The system integrates its own biological life support. The CO2 exhaled by the consumers (fishes, snails, microorganisms) is assimilated by water plants (Ceratophyllum demersum) which provide them with oxygen. The products of biomass degradation and excretion (mainly ammonia ions) are converted by bacteria into nitrite and nitrate. The latter is taken up by the plants as a nitrogen source together with other ions like phosphate. The plants convert light energy into chemical energy and their illumination is regulated via the oxygen concentration in the water by the control unit. In ground laboratory tests the system exhibited biological stability up to three month. The buffer capacity of the biological filter system is high enough to eliminate the degradation products of about one half of the dead animal biomass as shown in a ``crash test''. A test series using the laboratory model of the flight hardware demonstrated the biological stability and technical reliability with mission-identical loading and test duration. A comprehensive biological research program is established for the C.E.B.A.S. MINI-MODULE in which five German and three U.S.-American universities as well as the Russian Academy of Sciences are involved.

  15. Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness

    Science.gov (United States)

    2016-02-16

    evaluating the effectiveness of deterrence. Each provides persuasive arguments with logical evidence. However, they do not all come to the same conclusions...both a deterrence and assurance mission even though it was not planned or advertised as such. Since the intent of this mission was partly perceived

  16. Bringing RNA into View: RNA and Its Roles in Biology.

    Science.gov (United States)

    Atkins, John F.; Ellington, Andrew; Friedman, B. Ellen; Gesteland, Raymond F.; Noller, Harry F.; Pasquale, Stephen M.; Storey, Richard D.; Uhlenbeck, Olke C.; Weiner, Alan M.

    This guide presents a module for college students on ribonucleic acid (RNA) and its role in biology. The module aims to integrate the latest research and its findings into college-level biology and provide an opportunity for students to understand biological processes. Four activities are presented: (1) "RNA Structure: Tapes to Shapes"; (2) "RNA…

  17. Business analysis: The commercial mission of the International Asteroid Mission

    Science.gov (United States)

    The mission of the International Asteroid Mission (IAM) is providing asteroidal resources to support activities in space. The short term goal is to initiate IAM by mining a near-Earth, hydrous carbonaceous chondrite asteroid to service the nearer-term market of providing cryogenic rocket fuel in low lunar orbit (LLO). The IAM will develop and contract for the building of the transportation vehicles and equipment necessary for this undertaking. The long-term goal is to expand operations by exploiting asteroids in other manners, as these options become commercially viable. The primary business issues are what revenue can be generated from the baseline mission, how much will the mission cost, and how funding for this mission can be raised. These issues are addressed.

  18. The Impact of Mission Duration on a Mars Orbital Mission

    Science.gov (United States)

    Arney, Dale; Earle, Kevin; Cirillo, Bill; Jones, Christopher; Klovstad, Jordan; Grande, Melanie; Stromgren, Chel

    2017-01-01

    Performance alone is insufficient to assess the total impact of changing mission parameters on a space mission concept, architecture, or campaign; the benefit, cost, and risk must also be understood. This paper examines the impact to benefit, cost, and risk of changing the total mission duration of a human Mars orbital mission. The changes in the sizing of the crew habitat, including consumables and spares, was assessed as a function of duration, including trades of different life support strategies; this was used to assess the impact on transportation system requirements. The impact to benefit is minimal, while the impact on cost is dominated by the increases in transportation costs to achieve shorter total durations. The risk is expected to be reduced by decreasing total mission duration; however, large uncertainty exists around the magnitude of that reduction.

  19. Simulation of Mission Phases

    Science.gov (United States)

    Carlstrom, Nicholas Mercury

    2016-01-01

    This position with the Simulation and Graphics Branch (ER7) at Johnson Space Center (JSC) provided an introduction to vehicle hardware, mission planning, and simulation design. ER7 supports engineering analysis and flight crew training by providing high-fidelity, real-time graphical simulations in the Systems Engineering Simulator (SES) lab. The primary project assigned by NASA mentor and SES lab manager, Meghan Daley, was to develop a graphical simulation of the rendezvous, proximity operations, and docking (RPOD) phases of flight. The simulation is to include a generic crew/cargo transportation vehicle and a target object in low-Earth orbit (LEO). Various capsule, winged, and lifting body vehicles as well as historical RPOD methods were evaluated during the project analysis phase. JSC core mission to support the International Space Station (ISS), Commercial Crew Program (CCP), and Human Space Flight (HSF) influenced the project specifications. The simulation is characterized as a 30 meter +V Bar and/or -R Bar approach to the target object's docking station. The ISS was selected as the target object and the international Low Impact Docking System (iLIDS) was selected as the docking mechanism. The location of the target object's docking station corresponds with the RPOD methods identified. The simulation design focuses on Guidance, Navigation, and Control (GNC) system architecture models with station keeping and telemetry data processing capabilities. The optical and inertial sensors, reaction control system thrusters, and the docking mechanism selected were based on CCP vehicle manufacturer's current and proposed technologies. A significant amount of independent study and tutorial completion was required for this project. Multiple primary source materials were accessed using the NASA Technical Report Server (NTRS) and reference textbooks were borrowed from the JSC Main Library and International Space Station Library. The Trick Simulation Environment and User

  20. Hipparcos: mission accomplished

    Science.gov (United States)

    1993-08-01

    During the last few months of its life, as the high radiation environment to which the satellite was exposed took its toll on the on-board system, Hipparcos was operated with only two of the three gyroscopes normally required for such a satellite, following an ambitious redesign of the on-board and on-ground systems. Plans were in hand to operate the satellite without gyroscopes at all, and the first such "gyro- less" data had been acquired, when communication failure with the on-board computers on 24 June 1993 put an end to the relentless flow of 24000 bits of data that have been sent down from the satellite each second, since launch. Further attempts to continue operations proved unsuccessful, and after a short series of sub-systems tests, operations were terminated four years and a week after launch. An enormous wealth of scientific data was gathered by Hipparcos. Even though data analysis by the scientific teams involved in the programme is not yet completed, it is clear that the mission has been an overwhelming success. "The ESA advisory bodies took a calculated risk in selecting this complex but fundamental programme" said Dr. Roger Bonnet, ESA's Director of Science, "and we are delighted to have been able to bring it to a highly successful conclusion, and to have contributed unique information that will take a prominent place in the history and development of astrophysics". Extremely accurate positions of more than one hundred thousand stars, precise distance measurements (in most cases for the first time), and accurate determinations of the stars' velocity through space have been derived. The resulting HIPPARCOS Star Catalogue, expected to be completed in 1996, will be of unprecedented accuracy, achieving results some 10-100 times more accurate than those routinely determined from ground-based astronomical observatories. A further star catalogue, the Thyco Star Catalogue of more than a million stars, is being compiled from additional data accumulated by the

  1. Pursuing the journal mission.

    Science.gov (United States)

    Norko, Michael A; Griffith, Ezra E H; Coleman, Jacquelyn T

    2014-01-01

    The mission of The Journal of the American Academy of Psychiatry and the Law, as articulated in its Instructions for Authors, is to be a forum for the exchange of multidisciplinary ideas and thoughtful and respectful scholarly analyses related to the theory and practice of forensic psychiatry. Recent refinements of The Journal's structure and policy can be understood as an effort to articulate a vision for emphasizing vibrant exchange of diverse scholarly activities and ideas expressing the highest levels of professionalism and concern for the ethics of forensic psychiatry and publishing. In this article, we explore the challenges encountered in realizing that vision, including managing the tone and level of discourse, creating structure without inhibiting creativity, demonstrating respect for persons in the use of case report material, expanding and guiding the utilization of peer review, promoting the new voices of authors with less writing experience, defining conflicts of interest for publishing purposes, and maintaining editorial independence in the context of serving organizational needs. We illustrate these challenges with recent experiences, explicating the decisions of the senior editors in an effort to be transparent about The Journal's processes and to encourage feedback from our readers about the adequacy of these practices. © 2014 American Academy of Psychiatry and the Law.

  2. Draft Mission Plan Amendment

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-09-01

    The Department of Energy`s Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation`s spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs.

  3. STS-68 Mission Insignia

    Science.gov (United States)

    1994-01-01

    This STS-68 patch was designed by artist Sean Collins. Exploration of Earth from space is the focus of the design of the insignia, the second flight of the Space Radar Laboratory (SRL-2). SRL-2 was part of NASA's Mission to Planet Earth (MTPE) project. The world's land masses and oceans dominate the center field, with the Space Shuttle Endeavour circling the globe. The SRL-2 letters span the width and breadth of planet Earth, symbolizing worldwide coverage of the two prime experiments of STS-68: The Shuttle Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) instruments; and the Measurement of Air Pollution from Satellites (MAPS) sensor. The red, blue, and black colors of the insignia represent the three operating wavelengths of SIR-C/X-SAR, and the gold band surrounding the globe symbolizes the atmospheric envelope examined by MAPS. The flags of international partners Germany and Italy are shown opposite Endeavour. The relationship of the Orbiter to Earth highlights the usefulness of human space flights in understanding Earth's environment, and the monitoring of its changing surface and atmosphere. In the words of the crew members, the soaring Orbiter also typifies the excellence of the NASA team in exploring our own world, using the tools which the Space Program developed to explore the other planets in the solar system.

  4. Draft Mission Plan Amendment

    International Nuclear Information System (INIS)

    1991-09-01

    The Department of Energy's Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation's spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs

  5. Biological computation

    CERN Document Server

    Lamm, Ehud

    2011-01-01

    Introduction and Biological BackgroundBiological ComputationThe Influence of Biology on Mathematics-Historical ExamplesBiological IntroductionModels and Simulations Cellular Automata Biological BackgroundThe Game of Life General Definition of Cellular Automata One-Dimensional AutomataExamples of Cellular AutomataComparison with a Continuous Mathematical Model Computational UniversalitySelf-Replication Pseudo Code Evolutionary ComputationEvolutionary Biology and Evolutionary ComputationGenetic AlgorithmsExample ApplicationsAnalysis of the Behavior of Genetic AlgorithmsLamarckian Evolution Genet

  6. Liquid Effluents Program mission analysis

    International Nuclear Information System (INIS)

    Lowe, S.S.

    1994-01-01

    Systems engineering is being used to identify work to cleanup the Hanford Site. The systems engineering process transforms an identified mission need into a set of performance parameters and a preferred system configuration. Mission analysis is the first step in the process. Mission analysis supports early decision-making by clearly defining the program objectives, and evaluating the feasibility and risks associated with achieving those objectives. The results of the mission analysis provide a consistent basis for subsequent systems engineering work. A mission analysis was performed earlier for the overall Hanford Site. This work was continued by a ''capstone'' team which developed a top-level functional analysis. Continuing in a top-down manner, systems engineering is now being applied at the program and project levels. A mission analysis was conducted for the Liquid Effluents Program. The results are described herein. This report identifies the initial conditions and acceptable final conditions, defines the programmatic and physical interfaces and sources of constraints, estimates the resources to carry out the mission, and establishes measures of success. The mission analysis reflects current program planning for the Liquid Effluents Program as described in Liquid Effluents FY 1995 Multi-Year Program Plan

  7. Unity connecting module in SSPF

    Science.gov (United States)

    1998-01-01

    In the Space Station Processing Facility, the Unity connecting module, part of the International Space Station, is shown with Pressurized Mating Adapters 1 (left) and 2 (right) attached. Unity is scheduled to undergo testing of the common berthing mechanism to which other space station elements will dock. Unity is the primary payload on mission STS-88, targeted to launch Dec. 3, 1998. Other testing includes the Pad Demonstration Test to verify the compatibility of the module with the Space Shuttle as well as the ability of the astronauts to send and receive commands to Unity from the flight deck of the orbiter. Unity is expected to be ready for installation into the payload canister on Oct. 25, and transported to Launch Pad 39-A on Oct. 27. The Unity will be mated to the Russian-built Zarya control module which should already be in orbit at that time.

  8. The Asteroid Redirect Mission (ARM)

    Science.gov (United States)

    Abell, P. A.; Mazanek, D. D.; Reeves, D. M.; Chodas, P. W.; Gates, M. M.; Johnson, L. N.; Ticker, R. L.

    2016-01-01

    To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human spaceflight missions. Today, human flight experience extends only to Low-Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human spaceflight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth- Moon system, which will require weeks, months, or even years of transit time.

  9. GRACE Status at Mission End

    Science.gov (United States)

    Tapley, B. D.; Flechtner, F. M.; Watkins, M. M.; Bettadpur, S. V.

    2017-12-01

    The twin satellites of the Gravity Recovery and Climate Experiment (GRACE) were launched on March 17, 2002 and have operated for nearly 16 years. The mission objectives are to observe the spatial and temporal variations of the Earth's mass through its effects on the gravity field at the GRACE satellite altitude. The mass changes observed are related to both the changes within the solid earth and the change within and between the Erath system components. A significant cause of the time varying mass is water motion and the GRACE mission has provided a continuous decade long measurement sequence which characterizes the seasonal cycle of mass transport between the oceans, land, cryosphere and atmosphere; its inter-annual variability; and the climate driven secular, or long period, mass transport signals. The fifth reanalysis on the mission data set, the RL05 data, were released in mid-2013. With the planned launch of GRACE Follow-On in early 2018, plans are underway for a reanalysis that will be consistent with the GRACE FO processing standards. The mission is entering the final phases of its operation life with mission end expected to occur in early 2018. The current mission operations strategy emphasizes extending the mission lifetime to obtain an overlap with the GRACE FO. This presentation will review the mission status and the projections for mission lifetime, describe the current operations philosophy and its impact on the science data, discuss the issues related to achieving the GRACE and GRACE FO connection and discuss issues related to science data products during this phase of the mission period.

  10. American ASTP prime crew participate in photography mission briefing

    Science.gov (United States)

    1975-01-01

    The three American ASTP prime crew astronauts participate in a photography mission briefing in bldg 5 with Dr. Farouk El-Baz (wearing face mask) during Apollo Soyuz Test Project (ASTP) pre-flight activity at JSC. They are, left to right, Thomas P. Stafford, commander; Vance D. Brand, command module pilot; Dr. El-Baz; and Donald K. Slayton, docking module pilot. Dr. El-Baz is with the Center for Earth and Planetary Studies, National Air and Space Museum, Smithsonian Institution. The face mask is to protect the crewmen from possible exposure to disease prior to launch time.

  11. Planetary protection considerations for sample-return missions

    Science.gov (United States)

    Rummel, J.

    The analysis on Earth of materials returned from other solar system bodies, and beyond, is likely one of the most effective ways for us to learn about the origins, history, and present state of the universe outside of our home planet. In the past, the Apollo missions were able to return large quantities of material from the Moon, while missions currently flying (Genesis and Stardust) intend to return much smaller quantities of material. Planned and conceptualized future missions (cf., MUSES-C) intend to return a wide variety of samples such as those from a near-Earth asteroid, the surface and atmosphere of Mars , and perhaps once more from the Earth's Moon. In some cases, the bodies targeted for sample return missions may have the capability of harboring indigenous life, while in other cases there is scant possibility of that. Considerations in determining the potential for extraterrestrial contamination from sample return missions have been studied, and include such factors as the availability of liquid water in or on the target body, the availability of m tabolicallye useful energy sources, the likelihood that organic matter was available, and the overall temperature and radiation history of the sampled areas. Also of note is the potential that the natural influx to Earth of that materials in question (e.g., meteorites, etc.) might overwhelm the ability of a targeted sample-return mission to contribute something novel to the Earth's environment. Missions thought to pose a risk of extraterrestrial biological contamination are subject to a containment provision that may be very difficult to implement on a single, moderate-cost mission, but such steps are necessary to protect both our own planet and the health of solar-system exploration missions and the science they can do.

  12. The Magnetospheric Multiscale Mission

    Science.gov (United States)

    Burch, James

    Magnetospheric Multiscale (MMS), a NASA four-spacecraft mission scheduled for launch in November 2014, will investigate magnetic reconnection in the boundary regions of the Earth’s magnetosphere, particularly along its dayside boundary with the solar wind and the neutral sheet in the magnetic tail. Among the important questions about reconnection that will be addressed are the following: Under what conditions can magnetic-field energy be converted to plasma energy by the annihilation of magnetic field through reconnection? How does reconnection vary with time, and what factors influence its temporal behavior? What microscale processes are responsible for reconnection? What determines the rate of reconnection? In order to accomplish its goals the MMS spacecraft must probe both those regions in which the magnetic fields are very nearly antiparallel and regions where a significant guide field exists. From previous missions we know the approximate speeds with which reconnection layers move through space to be from tens to hundreds of km/s. For electron skin depths of 5 to 10 km, the full 3D electron population (10 eV to above 20 keV) has to be sampled at rates greater than 10/s. The MMS Fast-Plasma Instrument (FPI) will sample electrons at greater than 30/s. Because the ion skin depth is larger, FPI will make full ion measurements at rates of greater than 6/s. 3D E-field measurements will be made by MMS once every ms. MMS will use an Active Spacecraft Potential Control device (ASPOC), which emits indium ions to neutralize the photoelectron current and keep the spacecraft from charging to more than +4 V. Because ion dynamics in Hall reconnection depend sensitively on ion mass, MMS includes a new-generation Hot Plasma Composition Analyzer (HPCA) that corrects problems with high proton fluxes that have prevented accurate ion-composition measurements near the dayside magnetospheric boundary. Finally, Energetic Particle Detector (EPD) measurements of electrons and

  13. The SCOPE Mission

    International Nuclear Information System (INIS)

    Fujimoto, M.; Tsuda, Y.; Saito, Y.; Shinohara, I.; Takashima, T.; Matsuoka, A.; Kojima, H.; Kasaba, Y.

    2009-01-01

    In order to reach the new horizon of the space physics research, the Plasma Universe, via in-situ measurements in the Earth's magnetosphere, SCOPE will perform formation flying observations combined with high-time resolution electron measurements. The simultaneous multi-scale observations by SCOPE of various plasma dynamical phenomena will enable data-based study of the key space plasma processes from the cross-scale coupling point of view. Key physical processes to be studied are magnetic reconnection under various boundary conditions, shocks in space plasma, collisionless plasma mixing at the boundaries, and physics of current sheets embedded in complex magnetic geometries. The SCOPE formation is made up of 5 spacecraft and is put into the equatorial orbit with the apogee at 30 Re (Re: earth radius). One of the spacecraft is a large mother ship which is equipped with a full suite of particle detectors including ultra-high time resolution electron detector. Among other 4 small spacecraft, one remains near (∼10 km) the mother ship and the spacecraft-pair will focus on the electron-scale physics. Others at the distance of 100∼3000 km(electron∼ion spatial scales) from the mother ship will monitor plasma dynamics surrounding the mother-daughter pair. There is lively on-going discussion on Japan-Europe international collaboration (ESA's Cross-Scale), which would certainly make better the coverage over the scales of interest and thus make the success of the mission, i.e., clarifying the multi-scale nature of the Plasma Universe, to be attained at an even higher level.

  14. Bayesian module identification from multiple noisy networks

    OpenAIRE

    Zamani Dadaneh, Siamak; Qian, Xiaoning

    2016-01-01

    Background and motivations Module identification has been studied extensively in order to gain deeper understanding of complex systems, such as social networks as well as biological networks. Modules are often defined as groups of vertices in these networks that are topologically cohesive with similar interaction patterns with the rest of the vertices. Most of the existing module identification algorithms assume that the given networks are faithfully measured without errors. However, in many ...

  15. Mission Specialist Scott Parazynski checks his flight suit

    Science.gov (United States)

    1998-01-01

    STS-95 Mission Specialist Scott E. Parazynski gets help with his flight suit in the Operations and Checkout Building from a suit technician George Brittingham. The final fitting takes place prior to the crew walkout and transport to Launch Pad 39B. Targeted for launch at 2 p.m. EST on Oct. 29, the mission is expected to last 8 days, 21 hours and 49 minutes, and return to KSC at 11:49 a.m. EST on Nov. 7. The STS-95 mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

  16. Screens as light biological variable in microgravitational space environment.

    Science.gov (United States)

    Schlacht, S.; Masali, M.

    Foreword The ability of the biological organisms to orient themselves and to synchronize on the variations of the solar rhythms is a fundamental aspect in the planning of the human habitat above all when habitat is confined in the Space the planetary and in satellite outer space settlements In order to simulate the experience of the astronauts in long duration missions one of the dominant characteristics of the Space confined habitats is the absence of the earthlings solar cycles references The Sun is the main references and guidelines of the biological compass and timepiece The organism functions are influenced from the variation of the light in the round of the 24 hours the human circadian rhythms In these habitats it is therefore necessary to reproduce the color and intensity of the solar light variations along the arc of the day according to defined scientific programs assuring a better performance of the human organism subsubsection Multilayer Foldable Screens as biological environmental variable In the project Multilayer Foldable Screens are the monitors posed in the ceiling of an Outer Space habitat and are made of liquid crystals and covered with Kevlar they stand for a modulate and flexible structure for different arrangements and different visions Screens work sout s on all the solar light frequencies and display the images that the subject needs They are characterized from the emission of an environmental light that restores the earthly solar cycle for intensity and color temperature to irradiate

  17. Perfusion Bioreactor Module

    Science.gov (United States)

    Morrison, Dennis R.

    1990-01-01

    Perfusion bioreactor module, self-contained, closed-loop cell-culture system that operates in microgravity or on Earth. Equipment supports growth or long-term maintenance of cultures of human or other fragile cells for experiments in basic cell biology or process technology. Designed to support proliferation (initially at exponential rates of growth) of cells in complex growth medium and to maintain confluent cells in defined medium under conditions optimized to permit or encourage selected functions of cells, including secretion of products of cells into medium.

  18. AIR FORCE CYBER MISSION ASSURANCE SOURCES OF MISSION UNCERTAINTY

    Science.gov (United States)

    2017-04-06

    Much of the cyber capabilities that enable mission owners to function are outside their influence and often outside their visibility. This situation...mission owner wants, and the nature of risk management. The consequences of these issues are more than academic concerns as they have contributed to...perspective of the user and that of key leaders in positions to exert great influence on the future of cyber in the Air Force. While the Air Force likely

  19. MITA: An Italian minisatellite for small missions

    Science.gov (United States)

    Falvella, M. C.; Crisconio, M.; Lupi, T.; Sabatini, P.; Valentini, G.; Viola, F.

    On July 15th 2000 the first MITA (Italian Advanced Technology Minisatellite) was launched from Plesetsk (Russia) by a Cosmos rocket as a piggy-back of the CHAMP satellite. The main purpose of the first MITA mission is its in-flight validation. Furthermore the scientific payload NINA-2 of INFN (Istituto Nazionale di Fisica Nucleare) and the technological payload MTS-AOMS (Micro Tech Sensor for Attitude and Orbit Measurement System) were embarked. The NINA-2 goal is the survey of galactic and solar cosmic rays at 450 km altitude. MTS is an ESA multi-tasking autonomous sensor based on Active Pixel Sensor (star and horizon sensor), Angular Rate Sensor and Magnetic Field Sensor. In this paper the main MITA bus characteristics are reported, together with the description of the launch and the first commissioning phase. The first mission nominal orbit is circular, with a 450 Km altitude and a 87° inclination. The satellite attitude is nadir pointing, 3 axes stabilised. Spacecraft mass is 169.9 Kg. Two fixed solar panels provide an average power of 85 W EOL. The configuration of the satellite main body is based on a cubic shape module, made of Aluminium beams and honeycomb panels. The Mission Control Center is placed in Rome, while the TT&C stations are in Cordoba (Argentina) and, only during the commissioning phase, in Malindi (Kenia); Malindi TT&C station will then be replaced by Fucino (Italy). Since the contacts between spacecraft and the TT&C stations do not occur every orbit, the satellite on board S/W was designed in order to reach the nominal mode without telecommand from ground.

  20. The Ulysses mission: An introduction

    International Nuclear Information System (INIS)

    Marsden, R.G.

    1996-01-01

    On 30 September 1995, Ulysses completed its initial, highly successful, survey of the polar regions of the heliosphere in both southern and northern hemispheres, thereby fulfilling its prime mission. The results obtained to date are leading to a revision of many earlier ideas concerning the solar wind and the heliosphere. Now embarking on the second phase of the mission, Ulysses will continue along its out-of-ecliptic flight path for another complete orbit of the Sun. In contrast to the high-latitude phase of the prime mission, which occurred near solar minimum, the next polar passes (in 2000 and 2001) will take place when the Sun is at its most active

  1. The Science of Mission Assurance

    Directory of Open Access Journals (Sweden)

    Kamal Jabbour

    2011-01-01

    Full Text Available The intent of this article is to describe—and prescribe—a scientific framework for assuring mission essential functions in a contested cyber environment. Such a framework has profound national security implications as the American military increasingly depends on cyberspace to execute critical mission sets. In setting forth this prescribed course of action, the article will first decompose information systems into atomic processes that manipulate information at all six phases of the information lifecycle, then systematically define the mathematical rules that govern mission assurance.

  2. Vital role of nuclear data in space missions

    International Nuclear Information System (INIS)

    Tripathi, R.K.

    2008-01-01

    Nasa has a new vision for space exploration in the 21. Century encompassing a broad range of human and robotic missions including missions to Moon, Mars and beyond. Exposure from the hazards of severe space radiation in deep space long duration missions is a critical design driver. Thus, protection from the hazards of severe space radiation is of paramount importance for the new vision. Accurate risk assessments critically depend on the accuracy of the input information about the interaction of ions with materials, electronics and tissues. We have discussed some of the state-of-the-art cross sections database at Nasa and have demonstrated the role nuclear interaction plays in space missions. The impact of the cross sections on space missions has been shown by the assessment of dose exposure on Moon surface behind a number of materials with increasing hydrogen contents known to be a better radiation shielding material. In addition we have examined an approach to introduce reliability based design methods into shield evaluation and optimization procedure as a means to assess and control the uncertainties in shield design. Applications to Lunar missions for short and long-term duration display a large impact on the design outcome and the choice of the materials. For short duration missions all the examined materials have similar performance. However, for career astronauts who are exposed to longer duration space radiation over the period of time the choice of material plays a very critical role. Computational procedures based on deterministic solution of the Boltzmann equation are well suited for such procedures allowing optimization processes to be implemented, evaluation of biologically important rare events,and rapid analysis of possible shield optimization outcomes resulting from the biological model uncertainty parameter space

  3. Module descriptor

    DEFF Research Database (Denmark)

    Vincenti, Gordon; Klausen, Bodil; Kjær Jensen, Jesper

    2016-01-01

    The Module Descriptor including a Teacher’s Guide explains and describes how to work innovatively and co-creatively with wicked problems and young people. The descriptor shows how interested educators and lecturers in Europe can copy the lessons of the Erasmus+ project HIP when teaching their own...

  4. Memory Modulation

    NARCIS (Netherlands)

    Roozendaal, Benno; McGaugh, James L.

    2011-01-01

    Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive

  5. MISSION PROFILE AND DESIGN CHALLENGES FOR MARS LANDING EXPLORATION

    Directory of Open Access Journals (Sweden)

    J. Dong

    2017-07-01

    Full Text Available An orbiter and a descent module will be delivered to Mars in the Chinese first Mars exploration mission. The descent module is composed of a landing platform and a rover. The module will be released into the atmosphere by the orbiter and make a controlled landing on Martian surface. After landing, the rover will egress from the platform to start its science mission. The rover payloads mainly include the subsurface radar, terrain camera, multispectral camera, magnetometer, anemometer to achieve the scientific investigation of the terrain, soil characteristics, material composition, magnetic field, atmosphere, etc. The landing process is divided into three phases (entry phase, parachute descent phase and powered descent phase, which are full of risks. There exit lots of indefinite parameters and design constrain to affect the selection of the landing sites and phase switch (mortaring the parachute, separating the heat shield and cutting off the parachute. A number of new technologies (disk-gap-band parachute, guidance and navigation, etc. need to be developed. Mars and Earth have gravity and atmosphere conditions that are significantly different from one another. Meaningful environmental conditions cannot be recreated terrestrially on earth. A full-scale flight validation on earth is difficult. Therefore the end-to-end simulation and some critical subsystem test must be considered instead. The challenges above and the corresponding design solutions are introduced in this paper, which can provide reference for the Mars exploration mission.

  6. Laser modulator for LISA pathfinder

    Science.gov (United States)

    Voland, C.; Lund, G.; Coppoolse, W.; Crosby, P.; Stadler, M.; Kudielka, K.; Özkan, C.

    2017-11-01

    LISA Pathfinder is an ESA experiment to demonstrate the key technologies needed for the LISA mission to detect gravitational waves in space. The LISA Pathfinder spacecraft represents one arm of the LISA interferometer, containing an optical metrology system and two proof masses as inertial references for the drag-free control system. The LISA Pathfinder payload consists of two drag-free floating test masses located in the inertial sensors with their control electronics and an optical metrology subsystem. The optical metrology subsystem monitors the movement of both test masses relative to each other and to the spacecraft with very high sensitivity and resolution. This is achieved with a heterodyne Mach- Zehnder interferometer. This interferometer requires as input two coherent laser beams with a heterodyne frequency difference of a few kHz. To generate the two laser beams with a heterodyne frequency difference a Nd:YAG laser is used together with the Laser Modulator. The Nd:YAG laser generates a single coherent laser signal at a wavelength of 1064nm which is fibre coupled to the Laser Modulator. The Laser Modulator then generates the two optical beams with the required heterodyne frequency offset. In addition, the Laser Modulator is required to perform laser amplitude stabilization and optical path difference control for the two optical signals. The Laser Modulator consists of an optical unit - the LMU - and RF synthesiser, power amplification and control electronics. These electronics are all housed in the Laser Modulator Electronics (LME). The LMU has four primary functions: • Splitting of the input laser beam into two paths for later superposition in the interferometer. • Applying different frequency shifts to each of the beams. • Providing amplitude modulation control to each of the beams. • Providing active control of the optical path length difference between the two optical paths. The present paper describes the design and performance of the LMU

  7. Olefin Metathesis for Chemical Biology

    OpenAIRE

    Binder, Joseph B; Raines, Ronald T

    2008-01-01

    Chemical biology relies on effective synthetic chemistry for building molecules to probe and modulate biological function. Olefin metathesis in organic solvents is a valuable addition to this armamentarium, and developments during the previous decade are enabling metathesis in aqueous solvents for the manipulation of biomolecules. Functional group-tolerant ruthenium metathesis catalysts modified with charged moieties or hydrophilic polymers are soluble and active in water, enabling ring-openi...

  8. Science yield modeling with the Exoplanet Open-Source Imaging Mission Simulator (EXOSIMS)

    Science.gov (United States)

    Delacroix, Christian; Savransky, Dmitry; Garrett, Daniel; Lowrance, Patrick; Morgan, Rhonda

    2016-08-01

    We report on our ongoing development of EXOSIMS and mission simulation results for WFIRST. We present the interface control and the modular structure of the software, along with corresponding prototypes and class definitions for some of the software modules. More specifically, we focus on describing the main steps of our high-fidelity mission simulator EXOSIMS, i.e., the completeness, optical system and zodiacal light modules definition, the target list module filtering, and the creation of a planet population within our simulated universe module. For the latter, we introduce the integration of a recent mass-radius model from the FORECASTER software. We also provide custom modules dedicated to WFIRST using both the Hybrid Lyot Coronagraph (HLC) and the Shaped Pupil Coronagraph (SPC) for detection and characterization, respectively. In that context, we show and discuss the results of some preliminary WFIRST simulations, focusing on comparing different methods of integration time calculation, through ensembles (large numbers) of survey simulations.

  9. Green Propellant Infusion Mission Program

    Data.gov (United States)

    National Aeronautics and Space Administration — The mission is architected as a collaboration of NASA, Industry, and Air Force partners with the objective to advance the technology for propulsion components using...

  10. Mission Level Autonomy for USSV

    Science.gov (United States)

    Huntsberger, Terry; Stirb, Robert C.; Brizzolara, Robert

    2011-01-01

    On-water demonstration of a wide range of mission-proven, advanced technologies at TRL 5+ that provide a total integrated, modular approach to effectively address the majority of the key needs for full mission-level autonomous, cross-platform control of USV s. Wide baseline stereo system mounted on the ONR USSV was shown to be an effective sensing modality for tracking of dynamic contacts as a first step to automated retrieval operations. CASPER onboard planner/replanner successfully demonstrated realtime, on-water resource-based analysis for mission-level goal achievement and on-the-fly opportunistic replanning. Full mixed mode autonomy was demonstrated on-water with a seamless transition between operator over-ride and return to current mission plan. Autonomous cooperative operations for fixed asset protection and High Value Unit escort using 2 USVs (AMN1 & 14m RHIB) were demonstrated during Trident Warrior 2010 in JUN 2010

  11. UAV Mission Planning under Uncertainty

    National Research Council Canada - National Science Library

    Sakamoto, Philemon

    2006-01-01

    ... exclusively of unmanned vehicles. To properly manage and fully realize the capabilities of this UAV force, a control system must be in place that directs UAVs to targets and coordinates missions in a manner that provides an efficient...

  12. A Distributed Science Mission Testbed

    Data.gov (United States)

    National Aeronautics and Space Administration — The technology required for distributed spacecraft missions (DSM) is currently hamstrung by the lack of a realistic six-degree-of-freedom (DOF) testing platform.  A...

  13. Telepresence for Deep Space Missions

    Data.gov (United States)

    National Aeronautics and Space Administration — Incorporating telepresence technologies into deep space mission operations can give the crew and ground personnel the impression that they are in a location at time...

  14. Requirements for Common Bomber Mission Planning Environment

    National Research Council Canada - National Science Library

    White, III, Samuel G

    2006-01-01

    ...) level mission planning as a whole. Unfortunately, many of these initiatives have fallen short of seamlessly connecting the tactical level mission planning processes with the operational level or providing the unit-level mission...

  15. EOS Terra: Mission Status Constellation MOWG

    Science.gov (United States)

    Mantziaras, Dimitrios

    2016-01-01

    This EOS Terra Mission Status Constellation MOWG will discuss mission summary; spacecraft subsystems summary, recent and planned activities; inclination adjust maneuvers, conjunction history, propellant usage and lifetime estimate; and end of mission plan.

  16. Chandrayaan-2: India's First Soft-landing Mission to Moon

    Science.gov (United States)

    Mylswamy, Annadurai; Krishnan, A.; Alex, T. K.; Rama Murali, G. K.

    2012-07-01

    . Mission Elements:, On board segment of Chandrayaan-2 mission consists of a lunar Orbiter and a lunar Lander-Rover. The orbiter for Chandrayaan-2 mission is similar to that of Chandrayaan-1 from structural and propulsion aspects. Based on a study of various mission management and trajectory options, such as, separation of the Lander-Rover module in Earth Parking Orbit (EPO) or in lunar transfer trajectory (LTT) or in lunar polar orbit (LPO), the option of separating of this module at LTT, after required midcourse corrections, was selected as this offers an optimum mass and overall mission management advantage. The orbiter propulsion system will be used to transfer Orbiter-Lander-Rover composite from EPO to LTT. On reaching LTT, the Lander-Rover module will be separated from the orbiter module. The Lander-Rover and Orbiter modules are configured with individual propulsion and housekeeping systems. The indigenously developed Geostationary Satellite Launch Vehicle GSLV (Mk-II) will be used for this mission. The most critical aspect of its feasibility was an accurate evaluation of the scope for taking a 3200kg lift off mass into EPO. A Lander-Rover mass of 1270kg (including the propellant for soft landing) will provide sufficient margin for such a lift off within the capability of flight proven GSLV (Mk-II) for the EPO. Mission Scenario: ,GSLV (Mk-II) will launch the Lunar Orbiter coupled to the Lunar Lander-Rover into EPO (170 x 16980 km) following which the Orbiter will boost the orbit from EPO to LTT where the two modules will be separated. Both of them will make their independent journey towards moon and reach lunar polar orbit independently. The orbiter module will be initially placed in a circular polar orbit (200km) and the Lander-Rover module descends towards the lunar surface. After landing, a motorized rover with robotic arm and scientific instruments would be released on to the lunar surface. Although the exact landing location is yet to be finalized, a high

  17. Urinary albumin in space missions

    DEFF Research Database (Denmark)

    Cirillo, Massimo; De Santo, Natale G; Heer, Martina

    2002-01-01

    Proteinuria was hypothesized for space mission but research data are missing. Urinary albumin, as index of proteinuria, was analyzed in frozen urine samples collected by astronauts during space missions onboard MIR station and on ground (control). Urinary albumin was measured by a double antibody...... radioimmunoassay. On average, 24h urinary albumin was 27.4% lower in space than on ground; the difference was statistically significant. Low urinary albumin excretion could be another effect of exposure to weightlessness (microgravity)....

  18. Social Tagging of Mission Data

    Science.gov (United States)

    Norris, Jeffrey S.; Wallick, Michael N.; Joswig, Joseph C.; Powell, Mark W.; Torres, Recaredo J.; Mittman, David S.; Abramyan, Lucy; Crockett, Thomas M.; Shams, Khawaja S.; Fox, Jason M.; hide

    2010-01-01

    Mars missions will generate a large amount of data in various forms, such as daily plans, images, and scientific information. Often, there is a semantic linkage between images that cannot be captured automatically. Software is needed that will provide a method for creating arbitrary tags for this mission data so that items with a similar tag can be related to each other. The tags should be visible and searchable for all users. A new routine was written to offer a new and more flexible search option over previous applications. This software allows users of the MSLICE program to apply any number of arbitrary tags to a piece of mission data through a MSLICE search interface. The application of tags creates relationships between data that did not previously exist. These tags can be easily removed and changed, and contain enough flexibility to be specifically configured for any mission. This gives users the ability to quickly recall or draw attention to particular pieces of mission data, for example: Give a semantic and meaningful description to mission data; for example, tag all images with a rock in them with the tag "rock." Rapidly recall specific and useful pieces of data; for example, tag a plan as"driving template." Call specific data to a user s attention; for example, tag a plan as "for:User." This software is part of the MSLICE release, which was written in Java. It will run on any current Windows, Macintosh, or Linux system.

  19. Ulysses mission design after Challenger

    Science.gov (United States)

    Luthey, Joe L.; Peralta, Fernando; Pojman, Joan L.

    1990-01-01

    The delay of the Ulysses launch from May 1986 to October 1990, because of the Challenger disaster, has altered both the constraints under which the mission must be designed and the timing of several mission critical events. Safety and launch reliability concerns from the Shuttle have increased the effective launch window to durations greater than one hour. Fortuitously high declinations of the launch asymptote (DLA), of the order of the launch site latitude, ameliorate the impact of the new constraints on the launch window. Target overlays in the first hour of the launch window provide higher departure energies that improve mission performance and avoid a science schedule conflict at second opposition near the time of closest Jupiter approach. The mission design starts with the maximum earth departure energy that the upper stage can deliver within the launch constraints. The Jupiter arrival asymptotes are chosen from the optimal point of mission performance in the mission space defined in the Jupiter B-plane by contours mapped by the science and spacecraft constraints. More than half the orbital energy of the earth-to-Jupiter transfer orbit is lost in the Jupiter flyby, and the Jupiter gravitational assist rotates the orbit plane out of the ecliptic to an inclination of about 80 degrees.

  20. The ENVISAT Atmospheric Chemistry mission (GOMOS, MIPAS and SCIAMACHY) -Instrument status and mission evolution

    Science.gov (United States)

    Dehn, Angelika

    The ENVISAT ESA's satellite was launched on a polar orbit on March 2002. It carries on-board three atmospheric chemistry instruments: GOMOS, MIPAS and SCIAMACHY [1]. At the present time, although the mission expected lifetime of 5 years has been already exceeded, all the payload modules are in good to excellent status. The only limiting factor is the available fuel that is used for orbit control manoeuvre. A new strategy was proposed [2] that will allow to save fuel and to extend the mission up to 2013. Following this strategy, the altitude of the orbit will be lowered by 17 km starting from end of 2010 and the inclination will be allowed to drift. The new orbit scenario will result in a new repeating cycle with a variation of the Mean Local Solar Time (MLST). This will have an impact on both the in-flight operations, on the science data and on the mission. The simulations carried out for the atmospheric chemistry instruments show that the new orbit strategy will neither have a significant impact in the instrument operations nor on the quality of the science data. Therefore we expect that the atmospheric mission will continue nominally until the end of the platform life time, providing to the scientist a unique dataset of the most important geophysical parameters (e.g., trace gases, clouds, and aerosol) spanning a time interval of about 11 years. The aim of this paper is to review the overall ENVISAT atmospheric mission status for the past, present and future. The evolution of the instrument performances since launch will be analyzed with focus on the life-limited items monitoring. The tuning of the instrument in-flight operations decided to cope with instrument degradation or scientific needs will be described. The lessons learned on how to operate and monitor the instruments will be highlighted. Finally the expected evolution of the instrument performances until the ENVISAT end-of-life will be discussed. [1] H. Nett, J. Frerick, T. Paulsen, and G. Levrini, "The

  1. Origins Space Telescope Concept 1: Mid to Far Infrared Mission

    Science.gov (United States)

    Carter, Ruth; DiPirro, Michael; Origins Space Telescope Decadal Mission Study Team

    2018-01-01

    Origins Space Telescope (OST), is a NASA large mission concept designed to investigate the mid to far infrared sky. It would launch in the mid 2030’s, with mission development and implementation beginning in the mid-2020’s. This poster presents the overall architecture of OST Mission Concept 1. The Concept 1 telescope has a 9-meter diameter off-axis primary mirror, a three-mirror astigmat with a field steering mirror, covering the wavelength range of 6 to 600 µm. Five science instruments are on board the OST observatory for spectroscopy, imaging and coronagraphy. The instruments are the Medium Resolution Survey Spectrometer (MRSS), High Resolution Spectrometer (HRS), Far –IR Imaging and Polarimeter (FIP), Mid-IR Imaging Spectrometer and Coronagraph (MISC) and Heterodyne Instrument (HERO). The instruments are housed in the Instrument Accommodation Module (IAM). The Telescope and IAM are actively cooled to 4 Kelvin by relative high maturity 4 K cryocoolers To limit the Sun, Earth, Moon, and Spacecraft thermal radiation into the 4 K environment, multiple layers of sun shields similar to those used on JWST, are implemented. The sun-shields are also designed to minimize solar pressure and center of gravity discrepancies, thus resulting in the “sugar-scoop” like shape. To prevent locally generated stray light from entering the 4 Kelvin environment during mission operations, a 4 K baffle around the telescope and IAM is used. The OST Observatory will be inserted to a Sun-Earth L2 for mission operations.

  2. Low Thrust Trajectory Design for GSFC Missions

    Data.gov (United States)

    National Aeronautics and Space Administration — The Evolutionary Mission Trajectory Generator (EMTG) is a global trajectory optimization tool. EMTG is intended for use in designing interplanetary missions which...

  3. Robotic Mission Simulation Tool, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Energid Technologies proposes a software tool to predict robotic mission performance and support supervision of robotic missions even when environments and...

  4. A review of Spacelab mission management approach

    Science.gov (United States)

    Craft, H. G., Jr.

    1979-01-01

    The Spacelab development program is a joint undertaking of the NASA and ESA. The paper addresses the initial concept of Spacelab payload mission management, the lessons learned, and modifications made as a result of the actual implementation of Spacelab Mission 1. The discussion covers mission management responsibilities, program control, science management, payload definition and interfaces, integrated payload mission planning, integration requirements, payload specialist training, payload and launch site integration, payload flight/mission operations, and postmission activities. After 3.5 years the outlined overall mission manager approach has proven to be most successful. The approach does allow the mission manager to maintain the lowest overall mission cost.

  5. Systems Biology

    Energy Technology Data Exchange (ETDEWEB)

    Wiley, H S.

    2006-06-01

    The biology revolution over the last 50 years has been driven by the ascendancy of molecular biology. This was enthusiastically embraced by most biologists because it took us into increasingly familiar territory. It took mysterious processes, such as the replication of genetic material and assigned them parts that could be readily understood by the human mind. When we think of ''molecular machines'' as being the underlying basis of life, we are using a paradigm derived from everyday experience. However, the price that we paid was a relentless drive towards reductionism and the attendant balkanization of biology. Now along comes ''systems biology'' that promises us a solution to the problem of ''knowing more and more about less and less''. Unlike molecular biology, systems biology appears to be taking us into unfamiliar intellectual territory, such as statistics, mathematics and computer modeling. Not surprisingly, systems biology has met with widespread skepticism and resistance. Why do we need systems biology anyway and how does this new area of research promise to change the face of biology in the next couple of decades?

  6. Biological therapeutics

    National Research Council Canada - National Science Library

    Greenstein, Ben; Brook, Daniel A

    2011-01-01

    This introductory textbook covers all the main categories of biological medicines, including vaccines, hormonal preparations, drugs for rheumatoid arthritis and other connective tissue diseases, drugs...

  7. Ramakrishna Mission initiative impact study: final report

    Energy Technology Data Exchange (ETDEWEB)

    Chaurey, A.

    2000-07-06

    This report has been prepared by the Tata Energy Research Institute (TERI) for the National Renewable Energy Laboratory. It presents the results of the evaluation and impact assessment of solar photovoltaic lighting systems in the region of Sunderbans, West Bengal, that were deployed by a reputable non-governmental organization (Ramakrishna Mission) under the auspices of the INDO-US collaborative project. The objectives of the study were to evaluate the solar photovoltaic systems for their impact on the individual households as well as on the community, to assess the effectiveness of the implementation and financial mechanisms, and to draw a long-term strategy for NREL's activities in Sunderbans based on case studies of similar interventions. Under the project, provision was made to supply 300 domestic lighting systems (DLS) based on 53-Wp module capacity to individual households and a few other systems such as for lighting, medical refrigeration, and pumping water to community centers. For this study, 152 households were surveyed, of which 29 had also been a part of earlier pre- and post-installation surveys, 47 had been a part of the earlier post-installation survey, and 76 were households that were surveyed for the first time. A set of 46, out of the total 152 households, was selected for evaluating the systems for their technical performance with respect to module output, condition of the battery, and daily energy consumption. Of the total 300 modules, 2 had been stolen, 9 out of the total 300 batteries needed to be replaced, and 10 out of the 300 charge controllers were non-functional. The statistics for the surveyed households indicate 32 luminaire-related faults (blackening or flickering of compact fluorescent lights) and 11 other faults related to fuses, switches, etc.

  8. The Asteroid Redirect Mission (ARM)

    Science.gov (United States)

    Abell, Paul; Gates, Michele; Johnson, Lindley; Chodas, Paul; Mazanek, Dan; Reeves, David; Ticker, Ronald

    2016-07-01

    To achieve its long-term goal of sending humans to Mars, the National Aeronautics and Space Administration (NASA) plans to proceed in a series of incrementally more complex human spaceflight missions. Today, human flight experience extends only to Low-Earth Orbit (LEO), and should problems arise during a mission, the crew can return to Earth in a matter of minutes to hours. The next logical step for human spaceflight is to gain flight experience in the vicinity of the Moon. These cis-lunar missions provide a "proving ground" for the testing of systems and operations while still accommodating an emergency return path to the Earth that would last only several days. Cis-lunar mission experience will be essential for more ambitious human missions beyond the Earth-Moon system, which will require weeks, months, or even years of transit time. In addition, NASA has been given a Grand Challenge to find all asteroid threats to human populations and know what to do about them. Obtaining knowledge of asteroid physical properties combined with performing technology demonstrations for planetary defense provide much needed information to address the issue of future asteroid impacts on Earth. Hence the combined objectives of human exploration and planetary defense give a rationale for the Asteroid Re-direct Mission (ARM). Mission Description: NASA's ARM consists of two mission segments: 1) the Asteroid Redirect Robotic Mission (ARRM), the first robotic mission to visit a large (greater than ~100 m diameter) near-Earth asteroid (NEA), collect a multi-ton boulder from its surface along with regolith samples, demonstrate a planetary defense technique, and return the asteroidal material to a stable orbit around the Moon; and 2) the Asteroid Redirect Crewed Mission (ARCM), in which astronauts will take the Orion capsule to rendezvous and dock with the robotic vehicle, conduct multiple extravehicular activities to explore the boulder, and return to Earth with samples. NASA's proposed

  9. A Systems Approach to Biology (SAB).

    Science.gov (United States)

    Bush, Kenneth H.; And Others

    This pupil's study guide is intended to be used with audio-taped biology modules. Each of the units (on laboratory techniques, plant and animal diversity, chemistry, cells, energy, microbiology, genetics, and development) contains an abstract providing an overview of the unit, the rationale and performance objectives for each module, questions to…

  10. Missional theological curricula and institutions

    Directory of Open Access Journals (Sweden)

    Kruger P. du Preez

    2014-01-01

    Full Text Available The article argues in favour of an all-embracing missional framework for curriculum development for theological institutions. When the curriculum of a subject such as ecclesiologyhas a missional hermeneutic, it will naturally lead to missional congregations. The authors use issues raised by the Network for African Congregational Theology (NetACT institutions and the decisions of the Third Lausanne Congress in Cape Town (2010 as reference points in this article. They argue for a broad understanding of the concept �missional� and are of the opinion that curricula that are integrative, normative, contextual and missional will lead to spiritual maturity and will result in a positive impact on church and society as a whole. The missio Deias the work of the Trinitarian God is seen as being God�s initiative. The incarnational modelof Jesus Christ forms the basis for a theology and missiology where humility, vulnerability and servanthood play a pivotal role in curricula. An appeal is made for holistic missions with a strong emphasis on social engagement and the inclusion of community development. The Holy Spirit is seen as the empowering presence of the missio Dei, and the role of pneumatologyin missional curriculum development is underscored. Theological institutes should become�proclamation� institutions. Curricula should be ecumenical by nature and should include reaching the unreached and unengaged people groups. Theological education by extension is presented as an alternative way of decent ralised theological education.Intradisciplinary and/or interdisciplinary implications: The article calls for theology to be done with a missional hermeneutic, both intradisciplinarily and interdisciplinarily. The article involves theology and education and calls for all disciplines dealing with community development to collaborate.

  11. Tunable promoters in systems biology

    DEFF Research Database (Denmark)

    Mijakovic, Ivan; Petranovic, Dina; Jensen, Peter Ruhdal

    2005-01-01

    The construction of synthetic promoter libraries has represented a major breakthrough in systems biology, enabling the subtle tuning of enzyme activities. A number of tools are now available that allow the modulation of gene expression and the detection of changes in expression patterns. But, how...

  12. Life sciences and space research XXIII(2): Planetary biology and origins of life; Proceedings of the Topical Meeting and Workshops XX, XXI and XXIII of the 27th COSPAR Plenary Meeting, Espoo, Finland, July 18-29, 1988

    Science.gov (United States)

    Schwartz, A. W. (Editor); Dose, K. (Editor); Raup, D. M. (Editor); Klein, H. P. (Editor); Devincenzi, D. L. (Editor)

    1989-01-01

    This volume includes chapters on exobiology in space, chemical and early biochemical evolution, life without oxygen, potential for chemical evolution in the early environment of Mars, planetary protection issues and sample return missions, and the modulation of biological evolution by astrophysical phenomena. Papers are presented on the results of spaceflight missions, the action of some factors of space medium on the abiogenic synthesis of nucleotides, early peptidic enzymes, microbiology and biochemistry of the methanogenic archaeobacteria, and present-day biogeochemical activities of anaerobic bacteria and their relevance to future exobiological investigations. Consideration is also given to the development of the Alba Patera volcano on Mars, biological nitrogen fixation under primordial Martian partial pressures of dinitrogen, the planetary protection issues in advance of human exploration of Mars, and the difficulty with astronomical explanations of periodic mass extinctions.

  13. Use of a new glass microfibre histamine release method to study the modulation of the host response in human schistosomiasis mansoni. Individuals with different degrees of exposure to the disease show differing antibody biological function

    DEFF Research Database (Denmark)

    Satti, M.Z.; Ebbesen, F.; Vennervald, B.

    1996-01-01

    A new glass microfibre histamine release method was used to study the modulation of the host response in human schistosomiasis mansoni to improve our understanding of the role of basophils in the development of immunity in schistosomiasis mansoni. The histamine release from umbilical cord blood...

  14. Is synthetic biology mechanical biology?

    Science.gov (United States)

    Holm, Sune

    2015-12-01

    A widespread and influential characterization of synthetic biology emphasizes that synthetic biology is the application of engineering principles to living systems. Furthermore, there is a strong tendency to express the engineering approach to organisms in terms of what seems to be an ontological claim: organisms are machines. In the paper I investigate the ontological and heuristic significance of the machine analogy in synthetic biology. I argue that the use of the machine analogy and the aim of producing rationally designed organisms does not necessarily imply a commitment to mechanical biology. The ideal of applying engineering principles to biology is best understood as expressing recognition of the machine-unlikeness of natural organisms and the limits of human cognition. The paper suggests an interpretation of the identification of organisms with machines in synthetic biology according to which it expresses a strategy for representing, understanding, and constructing living systems that are more machine-like than natural organisms.

  15. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.

    Science.gov (United States)

    Stacey, David; Lourdusamy, Anbarasu; Ruggeri, Barbara; Maroteaux, Matthieu; Jia, Tianye; Cattrell, Anna; Nymberg, Charlotte; Banaschewski, Tobias; Bhattacharyya, Sohinee; Band, Hamid; Barker, Gareth; Bokde, Arun; Buchel, Christian; Carvalho, Fabiana; Conrod, Patricia; Desrivieres, Sylvane; Easton, Alanna; Fauth-Buehler, Mira; Fernandez-Medarde, Alberto; Flor, Herta; Frouin, Vincent; Gallinat, Jurgen; Garavanh, Hugh; Heinz, Andreas; Ittermann, Bernd; Lathrop, Mark; Lawrence, Claire; Loth, Eva; Mann, Karl; Martinot, Jean-Luc; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Rietschel, Marcella; Rotter, Andrea; Santos, Eugenio; Smolka, Michael; Sommer, Wolfgang; Mameli, Manuel; Spanagel, Rainer; Girault, Jean-Antoine; Mueller, Christian; Schumann, Gunter

    2016-04-01

    The mesolimbic dopamine system, composed primarily of dopaminergic neurons in the ventral tegmental area that project to striatal structures, is considered to be the key mediator of reinforcement-related mechanisms in the brain. Prompted by a genome-wide association meta-analysis implicating the Ras-specific guanine nucleotide-releasing factor 2 (RASGRF2) gene in the regulation of alcohol intake in men, we have recently shown that male Rasgrf2(-/-) mice exhibit reduced ethanol intake and preference accompanied by a perturbed mesolimbic dopamine system. We therefore propose that these mice represent a valid model to further elucidate the precise genes and mechanisms regulating mesolimbic dopamine functioning. Transcriptomic data from the nucleus accumbens (NAcc) of male Rasgrf2(-/-) mice and wild-type controls were analyzed by weighted gene coexpression network analysis (WGCNA). We performed follow-up genetic association tests in humans using a sample of male adolescents from the IMAGEN study characterized for binge drinking (n = 905) and ventral striatal activation during an fMRI reward task (n = 608). The WGCNA analyses using accumbal transcriptomic data revealed 37 distinct "modules," or functionally related groups of genes. Two of these modules were significantly associated with Rasgrf2 knockout status: M5 (p < 0.001) and M6 (p < 0.001). In follow-up translational analyses we found that human orthologues for the M5 module were significantly (p < 0.01) enriched with genetic association signals for binge drinking in male adolescents. Furthermore, the most significant locus, originating from the EH-domain containing 4 (EHD4) gene (p < 0.001), was also significantly associated with altered ventral striatal activity in male adolescents performing an fMRI reward task (pempirical < 0.001). It was not possible to determine the extent to which the M5 module was dysregulated in Rasgrf2(-/-) mice by perturbed mesolimbic dopamine signalling or by the loss of Rasgrf2

  16. Mesoscopic biology

    Indian Academy of Sciences (India)

    Abstract. In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. ... National Center for Biological Sciences, Tata Institute of Fundamental Research, UAS-GKVK Campus, Bangalore 560 065, India ...

  17. Computational biology

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Computation via biological devices has been the subject of close scrutiny since von Neumann’s early work some 60 years ago. In spite of the many relevant works in this field, the notion of programming biological devices seems to be, at best, ill-defined. While many devices are claimed or proved t...

  18. Mesoscopic biology

    Indian Academy of Sciences (India)

    In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in biological ...

  19. Recent Electric Propulsion Development Activities for NASA Science Missions

    Science.gov (United States)

    Pencil, Eric J.

    2009-01-01

    (The primary source of electric propulsion development throughout NASA is managed by the In-Space Propulsion Technology Project at the NASA Glenn Research Center for the Science Mission Directorate. The objective of the Electric Propulsion project area is to develop near-term electric propulsion technology to enhance or enable science missions while minimizing risk and cost to the end user. Major hardware tasks include developing NASA s Evolutionary Xenon Thruster (NEXT), developing a long-life High Voltage Hall Accelerator (HIVHAC), developing an advanced feed system, and developing cross-platform components. The objective of the NEXT task is to advance next generation ion propulsion technology readiness. The baseline NEXT system consists of a high-performance, 7-kW ion thruster; a high-efficiency, 7-kW power processor unit (PPU); a highly flexible advanced xenon propellant management system (PMS); a lightweight engine gimbal; and key elements of a digital control interface unit (DCIU) including software algorithms. This design approach was selected to provide future NASA science missions with the greatest value in mission performance benefit at a low total development cost. The objective of the HIVHAC task is to advance the Hall thruster technology readiness for science mission applications. The task seeks to increase specific impulse, throttle-ability and lifetime to make Hall propulsion systems applicable to deep space science missions. The primary application focus for the resulting Hall propulsion system would be cost-capped missions, such as competitively selected, Discovery-class missions. The objective of the advanced xenon feed system task is to demonstrate novel manufacturing techniques that will significantly reduce mass, volume, and footprint size of xenon feed systems over conventional feed systems. This task has focused on the development of a flow control module, which consists of a three-channel flow system based on a piezo-electrically actuated

  20. A Dual Launch Robotic and Human Lunar Mission Architecture

    Science.gov (United States)

    Jones, David L.; Mulqueen, Jack; Percy, Tom; Griffin, Brand; Smitherman, David

    2010-01-01

    paper describes a complete transportation architecture including the analysis of transportation element options and sensitivities including: transportation element mass to surface landed mass; lander propellant options; and mission crew size. Based on this analysis, initial design concepts for the launch vehicle, crew module and lunar lander are presented. The paper also describes how the dual launch lunar mission architecture would fit into a more general overarching human space exploration philosophy that would allow expanded application of mission transportation elements for missions beyond the Earth-moon realm.

  1. Dawn Mission Education and Public Outreach: Science as Human Endeavor

    Science.gov (United States)

    Cobb, W. H.; Wise, J.; Schmidt, B. E.; Ristvey, J.

    2012-12-01

    Dawn Education and Public Outreach strives to reach diverse learners using multi-disciplinary approaches. In-depth professional development workshops in collaboration with NASA's Discovery Program, MESSENGER and Stardust-NExT missions focusing on STEM initiatives that integrate the arts have met the needs of diverse audiences and received excellent evaluations. Another collaboration on NASA ROSES grant, Small Bodies, Big Concepts, has helped bridge the learning sequence between the upper elementary and middle school, and the middle and high school Dawn curriculum modules. Leveraging the Small Bodies, Big Concepts model, educators experience diverse and developmentally appropriate NASA activities that tell the Dawn story, with teachers' pedagogical skills enriched by strategies drawn from NSTA's Designing Effective Science Instruction. Dawn mission members enrich workshops by offering science presentations to highlight events and emerging data. Teachers' awareness of the process of learning new content is heightened, and they use that experience to deepen their science teaching practice. Activities are sequenced to enhance conceptual understanding of big ideas in space science and Vesta and Ceres and the Dawn Mission 's place within that body of knowledge Other media add depth to Dawn's resources for reaching students. Instrument and ion engine interactives developed with the respective science team leads help audiences engage with the mission payload and the data each instrument collects. The Dawn Dictionary, an offering in both audio as well as written formats, makes key vocabulary accessible to a broader range of students and the interested public. Further, as Dawn E/PO has invited the public to learn about mission objectives as the mission explored asteroid Vesta, new inroads into public presentations such as the Dawn MissionCast tell the story of this extraordinary mission. Asteroid Mapper is the latest, exciting citizen science endeavor designed to invite the

  2. Global Precipitation Measurement Mission: Architecture and Mission Concept

    Science.gov (United States)

    Bundas, David

    2005-01-01

    The Global Precipitation Measurement (GPM) Mission is a collaboration between the National Aeronautics and Space Administration (NASA) and the Japanese Aerospace Exploration Agency (JAXA), and other partners, with the goal of monitoring the diurnal and seasonal variations in precipitation over the surface of the earth. These measurements will be used to improve current climate models and weather forecasting, and enable improved storm and flood warnings. This paper gives an overview of the mission architecture and addresses some of the key trades that have been completed, including the selection of the Core Observatory s orbit, orbit maintenance trades, and design issues related to meeting orbital debris requirements.

  3. NASA Biological Specimen Repository

    Science.gov (United States)

    McMonigal, K. A.; Pietrzyk, R. A.; Sams, C. F.; Johnson, M. A.

    2010-01-01

    The NASA Biological Specimen Repository (NBSR) was established in 2006 to collect, process, preserve and distribute spaceflight-related biological specimens from long duration ISS astronauts. This repository provides unique opportunities to study longitudinal changes in human physiology spanning may missions. The NBSR collects blood and urine samples from all participating ISS crewmembers who have provided informed consent. These biological samples are collected once before flight, during flight scheduled on flight days 15, 30, 60, 120 and within 2 weeks of landing. Postflight sessions are conducted 3 and 30 days after landing. The number of in-flight sessions is dependent on the duration of the mission. Specimens are maintained under optimal storage conditions in a manner that will maximize their integrity and viability for future research The repository operates under the authority of the NASA/JSC Committee for the Protection of Human Subjects to support scientific discovery that contributes to our fundamental knowledge in the area of human physiological changes and adaptation to a microgravity environment. The NBSR will institute guidelines for the solicitation, review and sample distribution process through establishment of the NBSR Advisory Board. The Advisory Board will be composed of representatives of all participating space agencies to evaluate each request from investigators for use of the samples. This process will be consistent with ethical principles, protection of crewmember confidentiality, prevailing laws and regulations, intellectual property policies, and consent form language. Operations supporting the NBSR are scheduled to continue until the end of U.S. presence on the ISS. Sample distribution is proposed to begin with selections on investigations beginning in 2017. The availability of the NBSR will contribute to the body of knowledge about the diverse factors of spaceflight on human physiology.

  4. Composite Crew Module: Primary Structure

    Science.gov (United States)

    Kirsch, Michael T.

    2011-01-01

    In January 2007, the NASA Administrator and Associate Administrator for the Exploration Systems Mission Directorate chartered the NASA Engineering and Safety Center to design, build, and test a full-scale crew module primary structure, using carbon fiber reinforced epoxy based composite materials. The overall goal of the Composite Crew Module project was to develop a team from the NASA family with hands-on experience in composite design, manufacturing, and testing in anticipation of future space exploration systems being made of composite materials. The CCM project was planned to run concurrently with the Orion project's baseline metallic design within the Constellation Program so that features could be compared and discussed without inducing risk to the overall Program. This report discusses the project management aspects of the project including team organization, decision making, independent technical reviews, and cost and schedule management approach.

  5. Extended mission life support systems

    Science.gov (United States)

    Quattrone, P. D.

    1985-01-01

    Extended manned space missions which include interplanetary missions require regenerative life support systems. Manned mission life support considerations are placed in perspective and previous manned space life support system technology, activities and accomplishments in current supporting research and technology (SR&T) programs are reviewed. The life support subsystem/system technologies required for an enhanced duration orbiter (EDO) and a space operations center (SOC), regenerative life support functions and technology required for manned interplanetary flight vehicles, and future development requirements are outlined. The Space Shuttle Orbiters (space transportation system) is space cabin atmosphere is maintained at Earth ambient pressure of 14.7 psia (20% O2 and 80% N2). The early Shuttle flights will be seven-day flights, and the life support system flight hardware will still utilize expendables.

  6. Lunar Surface Mission Operations Scenario and Considerations

    Science.gov (United States)

    Arnold, Larissa S.; Torney, Susan E.; Rask, John Doug; Bleisath, Scott A.

    2006-01-01

    Planetary surface operations have been studied since the last visit of humans to the Moon, including conducting analog missions. Mission Operations lessons from these activities are summarized. Characteristics of forecasted surface operations are compared to current human mission operations approaches. Considerations for future designs of mission operations are assessed.

  7. Combining supramolecular chemistry with biology.

    Science.gov (United States)

    Uhlenheuer, Dana A; Petkau, Katja; Brunsveld, Luc

    2010-08-01

    Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins and lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine these synthetic supramolecular elements with biomolecules for the study of biological phenomena. This tutorial review focuses on the possibilities of the marriage of synthetic supramolecular architectures and biological systems. It highlights that synthetic supramolecular elements are for example ideal platforms for the recognition and modulation of proteins and cells. The unique features of synthetic supramolecular systems with control over size, shape, valency, and interaction strength allow the generation of structures fitting the demands to approach the biological problems at hand. Supramolecular chemistry has come full circle, studying the biology and its molecules which initially inspired its conception.

  8. Quantum Biology

    Directory of Open Access Journals (Sweden)

    Alessandro Sergi

    2009-06-01

    Full Text Available A critical assessment of the recent developmentsof molecular biology is presented.The thesis that they do not lead to a conceptualunderstanding of life and biological systems is defended.Maturana and Varela's concept of autopoiesis is briefly sketchedand its logical circularity avoided by postulatingthe existence of underlying living processes,entailing amplification from the microscopic to the macroscopic scale,with increasing complexity in the passage from one scale to the other.Following such a line of thought, the currently accepted model of condensed matter, which is based on electrostatics and short-ranged forces,is criticized. It is suggested that the correct interpretationof quantum dispersion forces (van der Waals, hydrogen bonding, and so onas quantum coherence effects hints at the necessity of includinglong-ranged forces (or mechanisms for them incondensed matter theories of biological processes.Some quantum effects in biology are reviewedand quantum mechanics is acknowledged as conceptually important to biology since withoutit most (if not all of the biological structuresand signalling processes would not even exist. Moreover, it is suggested that long-rangequantum coherent dynamics, including electron polarization,may be invoked to explain signal amplificationprocess in biological systems in general.

  9. Biological Oceanography

    Science.gov (United States)

    Dyhrman, Sonya

    2004-10-01

    The ocean is arguably the largest habitat on the planet, and it houses an astounding array of life, from microbes to whales. As a testament to this diversity and its importance, the discipline of biological oceanography spans studies of all levels of biological organization, from that of single genes, to organisms, to their population dynamics. Biological oceanography also includes studies on how organisms interact with, and contribute to, essential global processes. Students of biological oceanography are often as comfortable looking at satellite images as they are electron micrographs. This diversity of perspective begins the textbook Biological Oceanography, with cover graphics including a Coastal Zone Color Scanner image representing chlorophyll concentration, an electron micrograph of a dinoflagellate, and a photograph of a copepod. These images instantly capture the reader's attention and illustrate some of the different scales on which budding oceanographers are required to think. Having taught a core graduate course in biological oceanography for many years, Charlie Miller has used his lecture notes as the genesis for this book. The text covers the subject of biological oceanography in a manner that is targeted to introductory graduate students, but it would also be appropriate for advanced undergraduates.

  10. MIOSAT Mission Scenario and Design

    Science.gov (United States)

    Agostara, C.; Dionisio, C.; Sgroi, G.; di Salvo, A.

    2008-08-01

    MIOSAT ("Mssione Ottica su microSATellite") is a low-cost technological / scientific microsatellite mission for Earth Observation, funded by Italian Space Agency (ASI) and managed by a Group Agreement between Rheinmetall Italia - B.U. Spazio - Contraves as leader and Carlo Gavazzi Space as satellite manufacturer. Several others Italians Companies, SME and Universities are involved in the development team with crucial roles. MIOSAT is a microsatellite weighting around 120 kg and placed in a 525 km altitude sun-synchronuos circular LEO orbit. The microsatellite embarks three innovative optical payloads: Sagnac multi spectral radiometer (IFAC-CNR), Mach Zehender spectrometer (IMM-CNR), high resolution pancromatic camera (Selex Galileo). In addition three technological experiments will be tested in-flight. The first one is an heat pipe based on Marangoni effect with high efficiency. The second is a high accuracy Sun Sensor using COTS components and the last is a GNSS SW receiver that utilizes a Leon2 processor. Finally a new generation of 28% efficiency solar cells will be adopted for the power generation. The platform is highly agile and can tilt along and cross flight direction. The pointing accuracy is in the order of 0,1° for each axe. The pointing determination during images acquisition is <0,02° for the axis normal to the boresight and 0,04° for the boresight. This paper deals with MIOSAT mission scenario and definition, highlighting trade-offs for mission implementation. MIOSAT mission design has been constrained from challenging requirements in terms of satellite mass, mission lifetime, instrument performance, that have implied the utilization of satellite agility capability to improve instruments performance in terms of S/N and resolution. The instruments provide complementary measurements that can be combined in effective ways to exploit new applications in the fields of atmosphere composition analysis, Earth emissions, antropic phenomena, etc. The Mission

  11. Small Explorer for Advanced Missions - cubesat for scientific mission

    Science.gov (United States)

    Pronenko, Vira; Ivchenko, Nickolay

    2015-04-01

    A class of nanosatellites is defined by the cubesat standard, primarily setting the interface to the launcher, which allows standardizing cubesat preparation and launch, thus making the projects more affordable. The majority of cubesats have been launched are demonstration or educational missions. For scientific and other advanced missions to fully realize the potential offered by the low cost nanosatellites, there are challenges related to limitations of the existing cubesat platforms and to the availability of small yet sufficiently sensitive sensors. The new project SEAM (Small Explorer for Advanced Missions) was selected for realization in frames of FP-7 European program to develop a set of improved critical subsystems and to construct a prototype nanosatellite in the 3U cubesat envelope for electromagnetic measurements in low Earth orbit. The SEAM consortium will develop and demonstrate in flight for the first time the concept of an electromagnetically clean nanosatellite with precision attitude determination, flexible autonomous data acquisition system, high-bandwidth telemetry and an integrated solution for ground control and data handling. As the first demonstration, the satellite is planned to perform the Space Weather (SW) mission using novel miniature electric and magnetic sensors, able to provide science-grade measurements. To enable sensitive magnetic measurements onboard, the sensors must be deployed on booms to bring them away from the spacecraft body. Also other thorough yet efficient procedures will be developed to provide electromagnetic cleanliness (EMC) of the spacecraft. This work is supported by EC Framework 7 funded project 607197.

  12. Onboard Autonomy and Ground Operations Automation for the Intelligent Payload Experiment (IPEX) CubeSat Mission

    Science.gov (United States)

    Chien, Steve; Doubleday, Joshua; Ortega, Kevin; Tran, Daniel; Bellardo, John; Williams, Austin; Piug-Suari, Jordi; Crum, Gary; Flatley, Thomas

    2012-01-01

    The Intelligent Payload Experiment (IPEX) is a cubesat manifested for launch in October 2013 that will flight validate autonomous operations for onboard instrument processing and product generation for the Intelligent Payload Module (IPM) of the Hyperspectral Infra-red Imager (HyspIRI) mission concept. We first describe the ground and flight operations concept for HyspIRI IPM operations. We then describe the ground and flight operations concept for the IPEX mission and how that will validate HyspIRI IPM operations. We then detail the current status of the mission and outline the schedule for future development.

  13. Grand challenges in space synthetic biology.

    Science.gov (United States)

    Menezes, Amor A; Montague, Michael G; Cumbers, John; Hogan, John A; Arkin, Adam P

    2015-12-06

    Space synthetic biology is a branch of biotechnology dedicated to engineering biological systems for space exploration, industry and science. There is significant public and private interest in designing robust and reliable organisms that can assist on long-duration astronaut missions. Recent work has also demonstrated that such synthetic biology is a feasible payload minimization and life support approach as well. This article identifies the challenges and opportunities that lie ahead in the field of space synthetic biology, while highlighting relevant progress. It also outlines anticipated broader benefits from this field, because space engineering advances will drive technological innovation on Earth. © 2015 The Authors.

  14. The Europa Jupiter system mission

    Science.gov (United States)

    Clark, K.; Stankov, A.; Pappalardo, R. T.; Greeley, R.; Blanc, M.; Lebreton, J.-P.; van Houten, T.

    2009-04-01

    Europa Jupiter System Mission (EJSM)— would be an international mission that would achieve Decadal Survey and Cosmic Vision goals. NASA and ESA have concluded a joint study of a mission to Europa, Ganymede and the Jupiter system with orbiters developed by NASA and ESA; contributions by JAXA are also possible. The baseline EJSM architecture consists of two primary elements operating in the Jovian system: the NASA-led Jupiter Europa Orbiter (JEO), and the ESA-led Jupiter Ganymede Orbiter (JGO). JEO and JGO would execute an intricately choreographed exploration of the Jupiter System be-fore settling into orbit around Europa and Ganymede, respectively. JEO and JGO would carry eleven and ten complementary instruments, respectively, to monitor dynamic phenomena (such as Io's volcanoes and Jupi-ter's atmosphere), map the Jovian magnetosphere and its interactions with the Galilean satellites, and charac-terize water oceans beneath the ice shells of Europa and Ganymede. EJSM would fully addresses high priority science objectives identified by the National Research Coun-cil's (NRC's) Decadal Survey and ESA's Cosmic Vi-sion for exploration of the outer solar system. The De-cadal Survey recommended a Europa Orbiter as the highest priority outer planet flagship mission and also identified Ganymede as a highly desirable mission tar-get. EJSM would uniquely addresse several of the cen-tral themes of ESA's Cosmic Vision Programme, through its in-depth exploration of the Jupiter system and its evolution from origin to habitability. EJSM would investigate the potential habitability of the active ocean-bearing moons Europa and Gany-mede, detailing the geophysical, compositional, geo-logical, and external processes that affect these icy worlds. EJSM would also explore Io and Callisto, Jupi-ter's atmosphere, and the Jovian magnetosphere. By understanding the Jupiter system and unraveling its history, the formation and evolution of gas giant plan-ets and their satellites would be

  15. Biological Pathways

    Science.gov (United States)

    Skip to main content Biological Pathways Fact Sheet Enter Search Term(s): Español Research Funding An Overview Bioinformatics Current Grants Education and Training Funding Extramural Research News Features ...

  16. The Human Genome Project: Biology, Computers, and Privacy.

    Science.gov (United States)

    Cutter, Mary Ann G.; Drexler, Edward; Gottesman, Kay S.; Goulding, Philip G.; McCullough, Laurence B.; McInerney, Joseph D.; Micikas, Lynda B.; Mural, Richard J.; Murray, Jeffrey C.; Zola, John

    This module, for high school teachers, is the second of two modules about the Human Genome Project (HGP) produced by the Biological Sciences Curriculum Study (BSCS). The first section of this module provides background information for teachers about the structure and objectives of the HGP, aspects of the science and technology that underlie the…

  17. New Horizons Mission to Pluto

    Science.gov (United States)

    Delgado, Luis G.

    2011-01-01

    This slide presentation reviews the trajectory that will take the New Horizons Mission to Pluto. Included are photographs of the spacecraft, the launch vehicle, the assembled vehicle as it is being moved to the launch pad and the launch. Also shown are diagrams of the assembled parts with identifying part names.

  18. Pluto Express: Mission to Pluto

    Science.gov (United States)

    Giuliano, J. A.

    1996-01-01

    Pluto is the smallest, outermost and last-discovered planet in the Solar System and the only one that has never been visited by a spacecraft from Earth. Pluto and its relatively large satellite Charon are the destinations of a proposed spacecraft mission for the next decade, being developed for NASA by scientists and engineers at NASA's Jet Propulsion Laboratory.

  19. SURVIAC Overview Mission and Scope

    Science.gov (United States)

    2008-11-19

    Laser Weapon Simulation MIL AASPEM II (MIL II) Man-In-the-Loop Air-to-Air System Performance Evaluation Model RADGUNS* Radar Directed Gun System...Missions Laser Library • Test Reports • Symposia Proceedings • Analyses • Vulnerability Reports • Laser Weapon Reports • High Power Microwave Reports

  20. The DEMETER Science Mission Centre

    Czech Academy of Sciences Publication Activity Database

    Lagoutte, D.; Brochot, J.; Y.; de Carvalho, D.; Elie, F.; Harivelo, F.; Hobara, Y.; Madrias, L.; Parrot, M.; Pincon, J. L.; Berthelier, J. J.; Peschard, D.; Seran, E.; Gangloff, M.; Sauvaud, J. A.; Lebreton, J. P.; Štverák, Štěpán; Trávníček, Pavel M.; Grygorczuk, J.; Slominski, J.; Wronowski, R.; Barbier, S.; Bernard, P.; Gaboriaud, A.; Wallut, J. M.

    2006-01-01

    Roč. 54, č. 5 (2006), s. 428-440 ISSN 0032-0633 Institutional research plan: CEZ:AV0Z30420517 Keywords : Mission Centre * Data processing Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 1.509, year: 2006

  1. The Pascal Mars Scout Mission

    Science.gov (United States)

    Haberle, R. M.

    2003-01-01

    Pascal is a Mars Climate Network Mission that is being developed for NASA's Mars Scout Program. The mission would establish a network of 18 science weather stations distributed across the entire surface of Mars that operates for 3-10 Mars years (5.6- 18.8 Earth years). Pascal's instrument suite combines entry data from accelerometers and descent cameras, with landed data from pressure, opacity, temperature, wind speed, and water vapor to create a detailed global picture of Martian climate and weather. A panoramic landed camera system acquires images every 30 Sols to monitor changes in the landing environment due to winds. Analysis of data from the science stations, taken as often as once every 15 minutes, will provide a depth of understanding that will vastly increase our knowledge of Mars, and significantly impact site selection for future NASA missions. Pascal is the first mission ever to sample - in situ - the full global diversity of Mars and provide a continuous long-term presence on its surface.

  2. The Europa Ocean Discovery mission

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, B.C. [Los Alamos National Lab., NM (United States); Chyba, C.F. [Univ. of Arizona, Tucson, AZ (United States); Abshire, J.B. [National Aeronautics and Space Administration, Greenbelt, MD (United States). Goddard Space Flight Center] [and others

    1997-06-01

    Since it was first proposed that tidal heating of Europa by Jupiter might lead to liquid water oceans below Europa`s ice cover, there has been speculation over the possible exobiological implications of such an ocean. Liquid water is the essential ingredient for life as it is known, and the existence of a second water ocean in the Solar System would be of paramount importance for seeking the origin and existence of life beyond Earth. The authors present here a Discovery-class mission concept (Europa Ocean Discovery) to determine the existence of a liquid water ocean on Europa and to characterize Europa`s surface structure. The technical goal of the Europa Ocean Discovery mission is to study Europa with an orbiting spacecraft. This goal is challenging but entirely feasible within the Discovery envelope. There are four key challenges: entering Europan orbit, generating power, surviving long enough in the radiation environment to return valuable science, and complete the mission within the Discovery program`s launch vehicle and budget constraints. The authors will present here a viable mission that meets these challenges.

  3. Gravitational-wave Mission Study

    Science.gov (United States)

    Mcnamara, Paul; Jennrich, Oliver; Stebbins, Robin T.

    2014-01-01

    In November 2013, ESA selected the science theme, the "Gravitational Universe," for its third large mission opportunity, known as L3, under its Cosmic Vision Programme. The planned launch date is 2034. ESA is considering a 20% participation by an international partner, and NASA's Astrophysics Division has indicated an interest in participating. We have studied the design consequences of a NASA contribution, evaluated the science benefits and identified the technology requirements for hardware that could be delivered by NASA. The European community proposed a strawman mission concept, called eLISA, having two measurement arms, derived from the well studied LISA (Laser Interferometer Space Antenna) concept. The US community is promoting a mission concept known as SGO Mid (Space-based Gravitational-wave Observatory Mid-sized), a three arm LISA-like concept. If NASA were to partner with ESA, the eLISA concept could be transformed to SGO Mid by the addition of a third arm, augmenting science, reducing risk and reducing non-recurring engineering costs. The characteristics of the mission concepts and the relative science performance of eLISA, SGO Mid and LISA are described. Note that all results are based on models, methods and assumptions used in NASA studies

  4. Deep Space Gateway "Recycler" Mission

    Science.gov (United States)

    Graham, L.; Fries, M.; Hamilton, J.; Landis, R.; John, K.; O'Hara, W.

    2018-02-01

    Use of the Deep Space Gateway provides a hub for a reusable planetary sample return vehicle for missions to gather star dust as well as samples from various parts of the solar system including main belt asteroids, near-Earth asteroids, and Mars moon.

  5. Canada and Missions for Peace

    International Development Research Centre (IDRC) Digital Library (Canada)

    Initially, the international community was very enthusiastic about the use of UN peacekeeping to ensure the delivery of humanitarian aid and to restore order. ..... A mission for peace should not be conceived of as a form of intervention designed to solve the social, political, and economic problems of a polarized society.

  6. Space nuclear tug mission applications

    International Nuclear Information System (INIS)

    Hodge, J.R.; Rauen, L.A.

    1996-01-01

    An initial assessment indicates that the NEBA-1 and NEBA-3 bimodal reactor designs can be integrated into a reusable tug which is capable of supporting many missions including GSO delivery, GSO retrieval, lunar trajectory deliveries, interplanetary deliveries, and a variety of satellite servicing. The tug close-quote s nuclear thermal propulsion provides timely transport and payload delivery, with GSO deliveries on the order of 3 endash 7 days. In general, the tug may provide a number of potential benefits to users. The tug may, for example, extend the life of an existing on-orbit spacecraft, boost spacecraft which were not delivered to their operational orbit, offer increased payload capability, or possibly allow payloads to launch on smaller less expensive launch vehicles. Reusing the tug for 5 or 10 missions requires total reactor burn times of 50 and 100 hours, respectively. Shielding, boom structure, and radiator requirements were identified as key factors in the configuration layout. Economic feasibility is still under evaluation, but preliminary estimates indicate that average flight costs may range from $32 M to $34 M for a 10-mission vehicle and from $39 M to $42 M for a 5-mission vehicle. copyright 1996 American Institute of Physics

  7. MEMORY MODULATION

    Science.gov (United States)

    Roozendaal, Benno; McGaugh, James L.

    2011-01-01

    Our memories are not all created equally strong: Some experiences are well remembered while others are remembered poorly, if at all. Research on memory modulation investigates the neurobiological processes and systems that contribute to such differences in the strength of our memories. Extensive evidence from both animal and human research indicates that emotionally significant experiences activate hormonal and brain systems that regulate the consolidation of newly acquired memories. These effects are integrated through noradrenergic activation of the basolateral amygdala which regulates memory consolidation via interactions with many other brain regions involved in consolidating memories of recent experiences. Modulatory systems not only influence neurobiological processes underlying the consolidation of new information, but also affect other mnemonic processes, including memory extinction, memory recall and working memory. In contrast to their enhancing effects on consolidation, adrenal stress hormones impair memory retrieval and working memory. Such effects, as with memory consolidation, require noradrenergic activation of the basolateral amygdala and interactions with other brain regions. PMID:22122145

  8. The Europa Clipper Mission Concept

    Science.gov (United States)

    Pappalardo, Robert; Goldstein, Barry; Magner, Thomas; Prockter, Louise; Senske, David; Paczkowski, Brian; Cooke, Brian; Vance, Steve; Wes Patterson, G.; Craft, Kate

    2014-05-01

    A NASA-appointed Science Definition Team (SDT), working closely with a technical team from the Jet Propulsion Laboratory (JPL) and the Applied Physics Laboratory (APL), recently considered options for a future strategic mission to Europa, with the stated science goal: Explore Europa to investigate its habitability. The group considered several mission options, which were fully technically developed, then costed and reviewed by technical review boards and planetary science community groups. There was strong convergence on a favored architecture consisting of a spacecraft in Jupiter orbit making many close flybys of Europa, concentrating on remote sensing to explore the moon. Innovative mission design would use gravitational perturbations of the spacecraft trajectory to permit flybys at a wide variety of latitudes and longitudes, enabling globally distributed regional coverage of the moon's surface, with nominally 45 close flybys at altitudes from 25 to 100 km. We will present the science and reconnaissance goals and objectives, a mission design overview, and the notional spacecraft for this concept, which has become known as the Europa Clipper. The Europa Clipper concept provides a cost-efficient means to explore Europa and investigate its habitability, through understanding the satellite's ice and ocean, composition, and geology. The set of investigations derived from the Europa Clipper science objectives traces to a notional payload for science, consisting of: Ice Penetrating Radar (for sounding of ice-water interfaces within and beneath the ice shell), Topographical Imager (for stereo imaging of the surface), ShortWave Infrared Spectrometer (for surface composition), Neutral Mass Spectrometer (for atmospheric composition), Magnetometer and Langmuir Probes (for inferring the satellite's induction field to characterize an ocean), and Gravity Science (to confirm an ocean).The mission would also include the capability to perform reconnaissance for a future lander

  9. The EXIST Mission Concept Study

    Science.gov (United States)

    Fishman, Gerald J.; Grindlay, J.; Hong, J.

    2008-01-01

    EXIST is a mission designed to find and study black holes (BHs) over a wide range of environments and masses, including: 1) BHs accreting from binary companions or dense molecular clouds throughout our Galaxy and the Local Group, 2) supermassive black holes (SMBHs) lying dormant in galaxies that reveal their existence by disrupting passing stars, and 3) SMBHs that are hidden from our view at lower energies due to obscuration by the gas that they accrete. 4) the birth of stellar mass BHs which is accompanied by long cosmic gamma-ray bursts (GRBs) which are seen several times a day and may be associated with the earliest stars to form in the Universe. EXIST will provide an order of magnitude increase in sensitivity and angular resolution as well as greater spectral resolution and bandwidth compared with earlier hard X-ray survey telescopes. With an onboard optical-infra red (IR) telescope, EXIST will measure the spectra and redshifts of GRBs and their utility as cosmological probes of the highest z universe and epoch of reionization. The mission would retain its primary goal of being the Black Hole Finder Probe in the Beyond Einstein Program. However, the new design for EXIST proposed to be studied here represents a significant advance from its previous incarnation as presented to BEPAC. The mission is now less than half the total mass, would be launched on the smallest EELV available (Atlas V-401) for a Medium Class mission, and most importantly includes a two-telescope complement that is ideally suited for the study of both obscured and very distant BHs. EXIST retains its very wide field hard X-ray imaging High Energy Telescope (HET) as the primary instrument, now with improved angular and spectral resolution, and in a more compact payload that allows occasional rapid slews for immediate optical/IR imaging and spectra of GRBs and AGN as well as enhanced hard X-ray spectra and timing with pointed observations. The mission would conduct a 2 year full sky survey in

  10. IntroductionThe Cluster mission

    Directory of Open Access Journals (Sweden)

    C. P. Escoubet

    2001-09-01

    Full Text Available The Cluster mission, ESA’s first cornerstone project, together with the SOHO mission, dating back to the first proposals in 1982, was finally launched in the summer of 2000. On 16 July and 9 August, respectively, two Russian Soyuz rockets blasted off from the Russian cosmodrome in Baikonour to deliver two Cluster spacecraft, each into their proper orbit. By the end of August 2000, the four Cluster satellites had reached their final tetrahedral constellation. The commissioning of 44 instruments, both individually and as an ensemble of complementary tools, was completed five months later to ensure the optimal use of their combined observational potential. On 1 February 2001, the mission was declared operational. The main goal of the Cluster mission is to study the small-scale plasma structures in three dimensions in key plasma regions, such as the solar wind, bow shock, magnetopause, polar cusps, magnetotail and the auroral zones. With its unique capabilities of three-dimensional spatial resolution, Cluster plays a major role in the International Solar Terrestrial Program (ISTP, where Cluster and the Solar and Heliospheric Observatory (SOHO are the European contributions. Cluster’s payload consists of state-of-the-art plasma instrumentation to measure electric and magnetic fields from the quasi-static up to high frequencies, and electron and ion distribution functions from energies of nearly 0 eV to a few MeV. The science operations are coordinated by the Joint Science Operations Centre (JSOC, at the Rutherford Appleton Laboratory (UK, and implemented by the European Space Operations Centre (ESOC, in Darmstadt, Germany. A network of eight national data centres has been set up for raw data processing, for the production of physical parameters, and their distribution to end users all over the world. The latest information on the Cluster mission can be found at http://sci.esa.int/cluster/.

  11. Geomagnetism mission concepts after Swarm

    International Nuclear Information System (INIS)

    Michael Purucker; Sabaka, T.J.; Richard Holme

    2009-01-01

    Complete text of publication follows. While planning for the ESA Swarm mission has been a primary focus of geomagnetism over the past decade, the long time lags necessary for satellite missions dictate that planning for the next mission begin even before the launch of Swarm. Swarm will measure, for the first time, the E-W gradient of the magnetic field. In 2006, NASA launched a minisatellite magnetometer constellation mission (ST-5) to test technologies and software. The ST-5 constellation made the first along-track gradient measurements. One of the concepts under consideration for missions after Swarm is to systematically measure spatial gradients. The radial gradient could be measured using either an 'uncontrolled' fleet of satellites at different altitudes and local times, or by two or more satellites in a cartwheel configuration. Small-scale static features (degrees > 13) of the core field remain unknown because of their overlap with the crustal field, but they are of critical importance in core flow modeling. To what extent can small-scale features of the core field be separated from longer-wavelength crustal fields using radial gradients? We discuss this question in the context of a model study in which we attempt to recover separate core and crustal fields. The long wavelength crustal field model input is based on the seismic 3SMAC model, updated using MF-6. The core field model input is based on CHAOS-2. We will discuss the extent to which such a separation is ill-posed, and dependent on details of the parameterization. We will also discuss the extent to which such a separation is affected by the presence of annihilators.

  12. STS-108 Mission Highlights Resource Tape. Part 2 of 3

    Science.gov (United States)

    2002-01-01

    This video is a continuation of 'STS-108 Mission Highlights Resource Tape: Part 1 of 3' (Internal ID 2002049331). Flight day four footage continues with a video tour of the International Space Station (ISS). During flight day five, an exterior view of the Multipurpose Logistics Module (MPLM) is seen, followed by the crew unloading the supplies and equipment from the MPLM. Commander Dominic Gorie and Mission Specialist Linda Godwin are seen making preparations for the Extravehicular Activity (EVA) scheduled for the following day. Footage of an exterior view of the ISS is also shown. Flight day six footage includes Godwin and Mission Specialist Daniel Tani suiting up for their EVA and the installation of thermal blankets around the solar array wings of the ISS. Expedition 3 Commander Frank Culbertson is seen working in the ISS laboratory during flight day seven. Views are shown of Saudi Arabia and the Red Sea, the western coast of Australia, Cuba and Florida, and Switzerland and Northern Italy. During flight day eight, the crew is seen stowing objects in the MPLM for return to earth. The video concludes with footage of the treadmill used by the astronauts for physical exercise. Flight days nine through twelve are included in 'STS-108 Mission Highlights Resource Tape: Part 3 of 3' (Internal ID 2002049329).

  13. GAIA payload module mechanical development

    Science.gov (United States)

    Touzeau, S.; Sein, E.; Lebranchu, C.

    2017-11-01

    Gaia is the European Space Agency's cornerstone mission for global space astrometry. Its goal is to make the largest, most precise three-dimensional map of our Galaxy by surveying an unprecedented number of stars. This paper gives an overview of the mechanical system engineering and verification of the payload module. This development includes several technical challenges. First of all, the very high stability performance as required for the mission is a key driver for the design, which incurs a high degree of stability. This is achieved through the extensive use of Silicon Carbide (Boostec® SiC) for both structures and mirrors, a high mechanical and thermal decoupling between payload and service modules, and the use of high-performance engineering tools. Compliance of payload mass and volume with launcher capability is another key challenge, as well as the development and manufacturing of the 3.2-meter diameter toroidal primary structure. The spacecraft mechanical verification follows an innovative approach, with direct testing on the flight model, without any dedicated structural model.

  14. Homeland Biological Warfare Consequence Management: Capabilities and Needs Assessment

    Science.gov (United States)

    2001-04-01

    Improve Civilian Medical Response. Washington, D.C.: National Academy Press, 1999, 73-74 10 —Biological and Chemical Terrorism : Strategic Plan for...www.who.int/aboutwho/en/mission.htm Notes 1 —Biological and Chemical Terrorism : Strategic Plan for Preparedness and Response Recommendations of...Aberdeen Proving Ground, MD: Army Soldier and Biological Chemical Command, Domestic Preparedness Office, September 12, 2000. —Biological and Chemical

  15. Mission Design for the Innovative Interstellar Explorer Vision Mission

    Science.gov (United States)

    Fiehler, Douglas I.; McNutt, Ralph L.

    2005-01-01

    The Innovative Interstellar Explorer, studied under a NASA Vision Mission grant, examined sending a probe to a heliospheric distance of 200 Astronomical Units (AU) in a "reasonable" amount of time. Previous studies looked at the use of a near-Sun propulsive maneuver, solar sails, and fission reactor powered electric propulsion systems for propulsion. The Innovative Interstellar Explorer's mission design used a combination of a high-energy launch using current launch technology, a Jupiter gravity assist, and electric propulsion powered by advanced radioisotope power systems to reach 200 AU. Many direct and gravity assist trajectories at several power levels were considered in the development of the baseline trajectory, including single and double gravity assists utilizing the outer planets (Jupiter, Saturn, Uranus, and Neptune). A detailed spacecraft design study was completed followed by trajectory analyses to examine the performance of the spacecraft design options.

  16. Emirates Mars Mission (EMM) Overview

    Science.gov (United States)

    Sharaf, Omran; Amiri, Sarah; AlMheiri, Suhail; Alrais, Adnan; Wali, Mohammad; AlShamsi, Zakareyya; AlQasim, Ibrahim; AlHarmoodi, Khuloud; AlTeneiji, Nour; Almatroushi, Hessa; AlShamsi, Maryam; AlAwadhi, Mohsen; McGrath, Michael; Withnell, Pete; Ferrington, Nicolas; Reed, Heather; Landin, Brett; Ryan, Sean; Pramann, Brian

    2017-04-01

    United Arab Emirates (UAE) has entered the space exploration race with the announcement of Emirates Mars Mission (EMM), the first Arab Islamic mission to another planet, in 2014. Through this mission, UAE is to send an unmanned probe, called Hope probe, to be launched in summer 2020 and reach Mars by 2021 to coincide with UAE's 50th anniversary. Through a sequence of subsequent maneuvers, the spacecraft will enter a large science orbit that has a periapsis altitude of 20,000 km, an apoapsis altitude of 43,000 km, and an inclination of 25 degrees. The mission is designed to (1) characterize the state of the Martian lower atmosphere on global scales and its geographic, diurnal and seasonal variability, (2) correlate rates of thermal and photochemical atmospheric escape with conditions in the collisional Martian atmosphere, and (3) characterize the spatial structure and variability of key constituents in the Martian exosphere. These objectives will be met by four investigations with diurnal variability on sub-seasonal timescales which are (1) determining the three-dimensional thermal state of the lower atmosphere, (2) determining the geographic and diurnal distribution of key constituents in the lower atmosphere, (3) determining the abundance and spatial variability of key neutral species in the thermosphere, and (4) determining the three-dimensional structure and variability of key species in the exosphere. EMM will collect these information about the Mars atmospheric circulation and connections through a combination of three distinct instruments that image Mars in the visible, thermal infrared and ultraviolet wavelengths and they are the Emirates eXploration Imager (EXI), the Emirates Mars InfraRed Spectrometer (EMIRS), and the EMM Mars Ultraviolet Spectrometer (EMUS). EMM has passed its Mission Concept Review (MCR), System Requirements Review (SRR), System Design Review (SDR), and Preliminary Design Review (PDR) phases. The mission is led by Emiratis from Mohammed

  17. Biological preconcentrator

    Science.gov (United States)

    Manginell, Ronald P [Albuquerque, NM; Bunker, Bruce C [Albuquerque, NM; Huber, Dale L [Albuquerque, NM

    2008-09-09

    A biological preconcentrator comprises a stimulus-responsive active film on a stimulus-producing microfabricated platform. The active film can comprise a thermally switchable polymer film that can be used to selectively absorb and desorb proteins from a protein mixture. The biological microfabricated platform can comprise a thin membrane suspended on a substrate with an integral resistive heater and/or thermoelectric cooler for thermal switching of the active polymer film disposed on the membrane. The active polymer film can comprise hydrogel-like polymers, such as poly(ethylene oxide) or poly(n-isopropylacrylamide), that are tethered to the membrane. The biological preconcentrator can be fabricated with semiconductor materials and technologies.

  18. Europa Clipper Mission Concept Preliminary Planetary Protection Approach

    Science.gov (United States)

    Jones, Melissa; Schubert, Wayne; Newlin, Laura; Cooper, Moogega; Chen, Fei; Kazarians, Gayane; Ellyin, Raymond; Vaishampayan, Parag; Crum, Ray

    2016-07-01

    The science objectives of the proposed Europa Clipper mission consist of remotely characterizing any water within and beneath Europa's ice shell, investigating the chemistry of the surface and ocean, and evaluating geological processes that may permit Europa's ocean to possess the chemical energy necessary for life. The selected payload supporting the science objectives includes: Plasma Instrument for Magnetic Sounding (PIMS), Interior Characterization of Europa using Magnetometry (ICEMAG), Mapping Imaging Spectrometer for Europa (MISE), Europa Imaging System (EIS), Radar for Europa Assessment and Sounding: Ocean to Near-surface (REASON), Europa Thermal Emission Imaging System (E-THEMIS), MAss SPectrometer for Planetary EXploration/Europa (MASPEX), Ultraviolet Spectrograph/Europa (UVS), and SUrface DUst Mass Analyzer (SUDA). Launch is currently baselined as 2022. Pending the yet to be selected launch vehicle, the spacecraft would either arrive to the Jovian system on a direct trajectory in 2025 or an Earth-Venus-Earth-Earth gravity assist interplanetary trajectory arriving in 2030. The operational concept consists of multiple low-altitude flybys of Europa to obtain globally distributed regional coverage of the Europan surface. According to COSPAR Policy, it is currently anticipated that the Europa Clipper mission would be classified as a Category III mission. That is, the mission is to a body "of significant interest relative to the process of chemical evolution and/or the origin of life or for which scientific opinion provides a significant chance of contamination which could jeopardize a future biological experiment." Therefore, the expected driving planetary protection requirement for the mission is that the probability of inadvertent contamination of an ocean or other liquid water body shall be less than 1x10-4 per mission. This requirement applies until final disposition of the spacecraft, however in practice, would only apply until the spacecraft is

  19. Biological rhythms

    Science.gov (United States)

    Halberg, F.

    1975-01-01

    An overview is given of basic features of biological rhythms. The classification of periodic behavior of physical and psychological characteristics as circadian, circannual, diurnal, and ultradian is discussed, and the notion of relativistic time as it applies in biology is examined. Special attention is given to circadian rhythms which are dependent on the adrenocortical cycle. The need for adequate understanding of circadian variations in the basic physiological indicators of an individual (heart rate, body temperature, systolic and diastolic blood pressure, etc.) to ensure the effectiveness of prophylactic and therapeutic measures is stressed.

  20. Evidence for Alteration in Chemical and Physical Properties of Water and Modulation of its Biological Functions by Sunlight Transmitted through Color Ranges of the Visible Spectrum-A Novel Study

    Directory of Open Access Journals (Sweden)

    M. Rajeswara Rao

    2005-08-01

    Full Text Available We investigated the changes in the properties of water when exposed to sunlight for 40 days. We hypothesize and prove that solar irradiation to water entraps electromagnetic radiation as potential energy, which becomes kinetic energy in various systems. It is postulated that photochemically-induced energy transfers, associated with individual spectral emission of visible spectrum of solar light, exert diverse influences on biological systems. Bottles of distilled water, individually wrapped in spectral-colored cellophane were exposed to sunlight and compared to an unwrapped bottle to determine chemical and physical changes as well as modifications of biological properties. Each bottle of water was named according to the color of cellophane paper with letter E (stands for exposed as a prefix with (E-violet, E-indigo, E-blue, E-green, E-yellow, E-orange, and Ered. E-control (without wrap was exposed to polychromatic sunlight. This study addresses two main issues viz., the chemical and physical changes in E-water and its effect on biological activities. Chemical and physical composition analysis using inductively coupled plasma atomic emission spectrometry; physical conductance by a Wheatstone Bridge type conductivity meter; osmolarity by a vapor pressure osmometer; and, salt solubility profile of 10% sodium bicarbonate were determined. Furthermore, testing the effect of E-waters on human lymphocyte proliferation, mosquito larvae hatching and seed germination determined the functional role of solar radiation through specific spectrum/s of visible light on various biological processes. We found that water exposed to visible spectral emissions of sunlight had an altered elemental composition, electrical conductance, osmolarity and salt-solubility, as well as differences in bio-modulatory effects. A gradual increase in leaching of Boron from Eviolet to E-red was noted. E-indigo showed maximal increase in electrical conductance and maximal salt

  1. The Pascal Discovery Mission: A Mars Climate Network Mission

    Science.gov (United States)

    Haberle, R. M.; Catling, D. C.; Chassefiere, E.; Forget, F.; Hourdin, F.; Leovy, C. B.; Magalhaes, J.; Mihalov, J.; Pommereau, J. P.; Murphy, J. R.

    2000-01-01

    The climate of Mars is a major focus of Mars exploration. With the loss of MCO, however, it remains uncertain how it will be achieved. We argue that a truly dedicated climate mission to Mars should have both orbital and landed components, and that these should operate simultaneously for at least 1 Mars year if not longer. Pascal is a Discovery mission that emphasizes the landed component. Its principal goal is to establish a network of 24 small weather stations on the surface of Mars that will operate for 2 Mars years, with an extended mission option for an additional 8 Mars years bringing the total mission lifetime up to 10 Mars years. The stations will collect hourly measurements of pressure, temperature, and optical depth. After delivering the probes to Mars, Pascal's carrier spacecraft will go into an elliptical orbit which will serve as a relay for the landers, and a platform for synoptic imaging. These simultaneous measurements from the surface and from orbit will allow us to characterize the planet's general circulation and its interaction with the dust, water, and CO2 cycles. During entry, descent, and landing, each of Pascal's 24 probes will also measure the temperature structure of the atmosphere and acquire images of the surface. These data will allow us to determine the global structure of the atmosphere between 15 and 130 km, and characterize the local terrain to help interpret the landed data. The descent images are part of Pascal's outreach program, as the probe camera system will be developed by faculty-supervised student project. The intent is to generate enthusiasm for the Pascal mission by directly involving students. Pascal will be launched on a Delta II-7925 in August of 2005. A type I trajectory will deliver Pascal to Mars in January of 2006. On approach, the three-axis stabilized carrier spacecraft will spring deploy the Pascal probes in 4 separate salvo's of 6 each. Global coverage is achieved with small time-of-arrival adjustments in

  2. Detecting deception via eyeblink frequency modulation

    Directory of Open Access Journals (Sweden)

    Brandon S. Perelman

    2014-02-01

    Full Text Available To assess the efficacy of using eyeblink frequency modulation to detect deception about a third party, 32 participants were sent on a mission to deliver a package to an interviewer. 17 of the participants lied to the interviewer about the details of their mock mission and 15 responded truthfully. During the interview, eyeblink frequency data were collected via electromyography and recorded video. Liars displayed eyeblink frequency suppression while lying, while truth tellers exhibited an increase in eyeblink frequency during the mission relevant questioning period. The compensatory flurry of eyeblinks following deception observed in previous studies was absent in the present study. A discriminant function using eyeblink suppression to predict lying correctly classified 81.3% of cases, with a sensitivity of 88.2% and a specificity of 73.3%. This technique, yielding a reasonable sensitivity, shows promise for future testing as, unlike polygraph, it is compatible with distance technology.

  3. Search for extraterrestrial planets: the DARWIN mission

    Science.gov (United States)

    D'Arcio, Luigi; Karlsson, Anders

    2004-06-01

    The DARWIN mission is primarily devoted to the detection of earth-like exoplanets and the spectroscopic characterization of their atmospheres for key tracers of life. We will review the current instrumental concept, which is based on an interferometric array of six free-flying telescopes, passively cooled to 40K, operating in the 6-18 micron wavelength range. The angular resolution of DARWIN can be matched to a broad variety of observational scenarios by resizing the array between diameters of 50 m and 500 m. The flux of the parent star, which normally would overwhelm the planetary signal, is suppressed by a factor of 106 by destructive interference (nulling) over the full optical bandwidth, as the beams are combined. Then, the planetary signal can be separated from the zodiacal background signature by modulating the optical response of the interferometer. ESA is carrying out an extensive technology development programme to bring DARWIN-related technology to a maturity level in the three key areas of Formation Flying, Cryogenic Cooling and Mechanisms, and Nulling Interferometry. We report on the current status of optical development activities within this program, which includes the development of optical metrology, achromatic phase shifters, amplitude and polarization control devices, nulling interferometer demonstrators, mid-IR single-mode waveguides and advanced waveguide coupling devices.

  4. Java Mission Evaluation Workstation System

    Science.gov (United States)

    Pettinger, Ross; Watlington, Tim; Ryley, Richard; Harbour, Jeff

    2006-01-01

    The Java Mission Evaluation Workstation System (JMEWS) is a collection of applications designed to retrieve, display, and analyze both real-time and recorded telemetry data. This software is currently being used by both the Space Shuttle Program (SSP) and the International Space Station (ISS) program. JMEWS was written in the Java programming language to satisfy the requirement of platform independence. An object-oriented design was used to satisfy additional requirements and to make the software easily extendable. By virtue of its platform independence, JMEWS can be used on the UNIX workstations in the Mission Control Center (MCC) and on office computers. JMEWS includes an interactive editor that allows users to easily develop displays that meet their specific needs. The displays can be developed and modified while viewing data. By simply selecting a data source, the user can view real-time, recorded, or test data.

  5. Xenia Mission: Spacecraft Design Concept

    Science.gov (United States)

    Hopkins, R. C.; Johnson, C. L.; Kouveliotou, C.; Jones, D.; Baysinger, M.; Bedsole, T.; Maples, C. C.; Benfield, P. J.; Turner, M.; Capizzo, P.; hide

    2009-01-01

    The proposed Xenia mission will, for the first time, chart the chemical and dynamical state of the majority of baryonic matter in the universe. using high-resolution spectroscopy, Xenia will collect essential information from major traces of the formation and evolution of structures from the early universe to the present time. The mission is based on innovative instrumental and observational approaches: observing with fast reaction gamma-ray bursts (GRBs) with a high spectral resolution. This enables the study of their (star-forming) environment from the dark to the local universe and the use of GRBs as backlight of large-scale cosmological structures, observing and surveying extended sources with high sensitivity using two wide field-of-view x-ray telescopes - one with a high angular resolution and the other with a high spectral resolution.

  6. Space Shuttle mission: STS-67

    Science.gov (United States)

    1995-03-01

    The Space Shuttle Endeavor, scheduled to launch March 2, 1995 from NASA's Kennedy Space Center, will conduct NASA's longest Shuttle flight prior to date. The mission, designated STS-67, has a number of experiments and payloads, which the crew, commanded by Stephen S. Oswald, will have to oversee. This NASA press kit for the mission contains a general background (general press release, media services information, quick-look facts page, shuttle abort modes, summary timeline, payload and vehicle weights, orbital summary, and crew responsibilities); cargo bay payloads and activities (Astro 2, Get Away Special Experiments); in-cabin payloads (Commercial Minimum Descent Altitude Instrumentation Technology Associates Experiments, protein crystal growth experiments, Middeck Active Control Experiment, and Shuttle Amateur Radio Experiment); and the STS-67 crew biographies. The payloads and experiments are described and summarized to give an overview of the goals, objectives, apparatuses, procedures, sponsoring parties, and the assigned crew members to carry out the tasks.

  7. Status of the DIOS mission

    Science.gov (United States)

    Tawara, Y.; Sakurai, I.; Furuzawa, A.; Ohashi, T.; Ishisaki, Y.; Ezoe, Y.; Hoshino, A.; Akamatsu, H.; Ishikawa, K.; Mitsuda, K.; Yamasaki, N. Y.; Takei, Y.; Shinozaki, K.; Masui, K.; Yoshino, T.; Hagihara, T.; Kimura, S.; Yoshitake, H.

    2008-07-01

    We present the current status of a small X-ray mission DIOS (Diffuse Intergalactic Oxygen Surveyor), consisting of a 4-stage X-ray telescope and an array of TES microcalorimeters, cooled with mechanical coolers, with a total weight of about 400 kg. The mission will perform survey observations of warm-hot intergalactic medium using OVII and OVIII emission lines, with the energy coverage up to 1.5 keV. The wide field of view of about 50' diameter, superior energy resolution close to 2 eV FWHM, and very low background will together enable us a wide range of science for diffuse X-ray sources. We briefly describe the current status of the development of the satellite, and the subsystems.

  8. White Label Space GLXP Mission

    Science.gov (United States)

    Barton, A.

    2012-09-01

    This poster presents a lunar surface mission concept and corresponding financing approach developed by the White Label Space team, an official competitor in the Google Lunar X PRIZE. The White Label Space team's origins were in the European Space Agency's ESTEC facility in the Netherlands. Accordingly the team's technical headquarters are located just outside ESTEC in the Space Business Park. The team has active partners in Europe, Japan and Australia. The team's goal is to provide a unique publicity opportunity for global brands to land on the moon and win the prestigious Google Lunar X PRIZE. The poster presents the main steps to achieve this goal, the cost estimates for the mission, describes the benefits to the potential sponsors and supporters, and details the progress achieved to date.

  9. Biology relevant to space radiation

    International Nuclear Information System (INIS)

    Fry, R.J.M.

    1997-01-01

    There are only very limited data on the health effects to humans from the two major components of the radiations in space, namely protons and heavy ions. As a result, predictions of the accompanying effects must be based either on (1) data generated through studies of experimental systems exposed on earth at rates and fluences higher than those in space, or (2) extrapolations from studies of gamma and x rays. Better information is needed about the doses, dose rates, and the energy and LET spectra of the radiations at the organ level that are anticipated to be encountered during extended space missions. In particular, there is a need for better estimates of the relationship between radiation quality and biological effects. In the case of deterministic effects, it is the threshold that is important. The possibility of the occurrence of a large solar particle event (SPE) requires that such effects be considered during extended space missions. Analyses suggest, however, that it is feasible to provide sufficient shielding so as to reduce such effects to acceptable levels, particularly if the dose rates can be limited. If these analyses prove correct, the primary biological risks will be the stochastic effects (latent cancer induction). The contribution of one large SPE to the risk of stochastic effects while undesirable will not be large in comparison to the potential total dose on a mission of long duration

  10. The EUCLID-NIS Mission

    Science.gov (United States)

    Balcells, M.

    Obtaining a measure of the baryonic acoustic oscillations (BAO) is among the top goals of cosmology in the beginning of the twenty-first century. Detection of BAOs offers the possibility to test the standard cosmological model, by providing strong constraints on the equation of state of dark energy. The EUCLID-NIS mission proposes to measure BAOs by mapping the 3D distribution of baryons at intermediate redshift, 1 micromirror devices (DMD) from Texas Instruments.

  11. Design, qualification and operation of nuclear rockets for safe Mars missions

    International Nuclear Information System (INIS)

    Buden, D.; Madsen, W.W.; Olson, T.S.; Redd, L.R.

    1993-01-01

    Nuclear thermal propulsion modules planned for use on crew missions to Mars improve mission reliability and overall safety of the mission. This, as well as all other systems, are greatly enhanced if the system specifications take into account safety from design initiation, and operational considerations are well thought through and applied. For instance, the use of multiple engines in the propulsion module can lead to very high system safety and reliability. Operational safety enhancements may include: the use of multiple perigee burns, thus allowing time to ensure that all systems are functioning properly prior to departure from Earth orbit; the ability to perform all other parts of the mission in a degraded mode with little or no degradation of the mission; and the safe disposal of the nuclear propulsion module in a heliocentric orbit out of the ecliptic plane. The standards used to qualify nuclear rockets are one of the main cost drivers of the program. Concepts and systems that minimize cost and risk will rely on use of the element and component levels to demonstrate technology readiness and validation. Subsystem or systems testing then is only needed for verification of performance. Also, these will be the safest concepts because they will be more thoroughly understood and the safety margins will be well established and confirmed by tests

  12. Aquatic modules for bioregenerative life support systems: Developmental aspects based on the space flight results of the C.E.B.A.S. mini-module

    Science.gov (United States)

    Blüm, V.

    The Closed Equilibrated Biological Aquatic System (C.E.B.A.S.) is an artificial aquatic ecosystem which contains teleost fishes, water snails, ammonia oxidizing bacteria and edible non-gravitropic water plants. It serves as a model for aquatic food production modules which are not seriously affected by microgravity and other space conditions. Its space flight version, the so-called C.E.B.A.S. MINI-MODULE was already successfidly tested in the STS-89 and STS-90 (NEUROLAB) missions. It will be flown a third time in space with the STS-107 mission in January 2003. All results obtained so far in space indicate that the basic concept of the system is more than suitable to drive forward its development. The C.E.B.A.S. MINI-MODULE is located within a middeck locker with limited space for additional components. These technical limitations allow only some modifications which lead to a maximum experiment time span of 120 days which is not long enough for scientifically essential multi-generation-experiments. The first necessary step is the development of "harvesting devices" for the different organisms. In the limited space of the plant bioreactor a high biomass production leads to self-shadowing effects which results in an uncontrolled degradation and increased oxygen consumption by microorganisms which will endanger the fishes and snails. It was shown already that the latter reproduce excellently in space and that the reproductive functions of the fish species are not affected. Although the parent-offspring-cannibalism of the ovoviviparous fish species ( Xiphophorus helleri) serves as a regulating factor in population dynamics an uncontrolled snail reproduction will also induce an increased oxygen consumption per se and a high ammonia concentration in the water. If harvesting locks can be handled by astronauts in, e. g., 4-week intervals their construction is not very difficult and basic technical solutions are already developed. The second problem is the feeding of the

  13. Aquatic modules for bioregenerative life support systems: Developmental aspects based on the space flight results of the C.E.B.A. Mini Module

    Science.gov (United States)

    Bluem, S. V.

    The Closed Equilibrated Biological Aquatic System (C.E.B.A.S.) is an artificial aquatic ecosystem which contains teleost fishes, water snails, ammonia oxidizing bacteria and edible non-gravitropic water plants. It serves as a model for aquatic food production modules which are not seriously affected by microgravity and other space conditions. Its space flight version, the so-called C.E.B.AS. MINI-MODULE was already successfully tested in the STS-89 and STS 90 (NEUROLAB) missions.- I will be flown a third time in space with the STS 107 mission in July 2002. All- results obtained so far in space indicate that the basic concept of the system is more than suitable to drive forward its development. The C.E.B.A.S. MINI-MODULE is located within a middeck locker whith limited the space for additional components. These technical limitations allow only some modifications which lead to a maximum experiment time span of 120 days which is not long enough for the demanded scientifically essential multi-generation-experiments. This first necessary step is the development of "harvesting devices" for the different organisms. In the limited space of the plant bioreactor a high biomass production leads to self- shadowing effects which results in an uncontrolled degradation and increased oxygen consum ption by microorganisms which will endanger the fishes and snails. It was shown already that the latter reproduce excellently in space and that the reproductive functions of the fishes are not affected. Although the parent - offspring- cannibalism of the used ovoviviparous fish species (Xiphophorus helleri) serves as a regulating factor in population dynamics an uncontrolled snail reproduction will also induce an increased ox gen consumption per se and a high ammonia concentrationy in the water. If harvesting locks can be handled by astronauts in, e. g., 4w e e k- intervals their construction is not very difficult and basic technical solutions are already developed. The second problem is

  14. Lunar and Planetary Science XXXV: Future Missions to the Moon

    Science.gov (United States)

    2004-01-01

    This document contained the following topics: A Miniature Mass Spectrometer Module; SELENE Gamma Ray Spectrometer Using Ge Detector Cooled by Stirling Cryocooler; Lunar Elemental Composition and Investigations with D-CIXS X-Ray Mapping Spectrometer on SMART-1; X-Ray Fluorescence Spectrometer Onboard the SELENE Lunar Orbiter: Its Science and Instrument; Detectability of Degradation of Lunar Impact Craters by SELENE Terrain Camera; Study of the Apollo 16 Landing Site: As a Standard Site for the SELENE Multiband Imager; Selection of Targets for the SMART-1 Infrared Spectrometer (SIR); Development of a Telescopic Imaging Spectrometer for the Moon; The Lunar Seismic Network: Mission Update.

  15. Fast Convolution Module (Fast Convolution Module)

    National Research Council Canada - National Science Library

    Bierens, L

    1997-01-01

    This report describes the design and realisation of a real-time range azimuth compression module, the so-called 'Fast Convolution Module', based on the fast convolution algorithm developed at TNO-FEL...

  16. Mission STS-113 Crew Insignia

    Science.gov (United States)

    2002-01-01

    This is the crew patch for the Shuttle Endeavor STS-113 mission, the 16th American assembly flight, and 112th overall American flight to the International Space Station (ISS). STS-113 mission objectives included the delivery of the Expedition Six Crew to the ISS, the return of Expedition Five back to Earth, and the installation and activation of the Port 1 Integrated Truss Assembly (P1). The first major component installed on the left side of the Station, the P1 truss provides an additional three External Thermal Control System radiators. Three space walks, aided by the use of the Robotic Manipulator Systems of both the Shuttle and the Station, were performed in the installation of P1. Also, more than 2,500 pounds (1,134 kilograms) of cargo were transferred between the Shuttle and Station. The Space Shuttle Orbiter Endeavor launched on November 23, 2002 from Kennedy's launch pad 39A and returned 11 days later on December 4, 2002. The patch depicts the Space Shuttle Endeavour docked to the ISS during the installation of the P1 truss with the gold astronaut symbol in the background. The seven stars at the top left center of the patch are the seve brightest stars in the constellation Orion. They represent the combined seven crew members (four Shuttle and three Expedition Six). The three stars to the right of the astronaut symbol represent the returning Expedition Five crew members. The Roman Numeral CXIII represents the mission number 113.

  17. The Van Allen Probes mission

    CERN Document Server

    Burch, James

    2014-01-01

    This collection of articles provides broad and detailed information about NASA’s Van Allen Probes (formerly known as the Radiation Belt Storm Probes) twin-spacecraft Earth-orbiting mission. The mission has the objective of achieving predictive understanding of the dynamic, intense, energetic, dangerous, and presently unpredictable belts of energetic particles that are magnetically trapped in Earth’s space environment above the atmosphere. It documents the science of the radiation belts and the societal benefits of achieving predictive understanding. Detailed information is provided about the Van Allen Probes mission design, the spacecraft, the science investigations, and the onboard instrumentation that must all work together to make unprecedented measurements within a most unforgiving environment, the core of Earth’s most intense radiation regions.
 This volume is aimed at graduate students and researchers active in space science, solar-terrestrial interactions and studies of the up...

  18. Manned NEO Mission EVA Challenges

    Science.gov (United States)

    2011-01-01

    The President has proposed to land astronauts on an asteroid by 2025. However, Manned NEO (Near Earth Objects) Missions will present a host of new and exciting problems that will need to be better defined and solved before such a mission is launched. Here I will focus on the challenges for conducting asteroidal EVAs. Specfically, crew locomotion, sampling, drilling, documentation, and instrument deployment issues arising from the micro gravity environments associated with NEOs. Therefore, novel methods and techniques will need to be developed and tested in order to achieve specific mission science objectives. Walking or driving on the surface will not be a realistic option due to the small sizes (10 s to 100 s of meters in diameter) and hence extremely low gravity of the present day known candidate NEOs. EVAs will have to be carried out with crew members either using a self propelled device (akin to the MMU and SAFER units used on Shuttle/ISS) and or tethers. When using tethers a grid system could be deployed which is anchored to the asteroid. These anchor points could be inserted by firing penetrators into the surface from the spacecraft while it is still at a safe standoff distance. These penetrators would pull double duty by being laden with scientific instrumentation to probe the subsurface. Dust and debris generated by sample collection and locomotion in a microgravity environment could also pose some problems that will require forethought.

  19. Gaia Space Mission and Quasars

    Energy Technology Data Exchange (ETDEWEB)

    Zwitter, Tomaž, E-mail: tomaz.zwitter@fmf.uni-lj.si [Faculty of Mathematics and Physics, University of Ljubljana, Ljubljana (Slovenia)

    2017-11-15

    Quasars are often considered to be point-like objects. This is largely true and allows for an excellent alignment of the optical positional reference frame of the ongoing ESA mission Gaia with the International Celestial Reference Frame. But presence of optical jets in quasars can cause shifts of the optical photo-centers at levels detectable by Gaia. Similarly, motion of emitting blobs in the jet can be detected as proper motion shifts. Gaia's measurements of spectral energy distribution for around a million distant quasars is useful to determine their redshifts and to assess their variability on timescales from hours to years. Spatial resolution of Gaia allows to build a complete magnitude limited sample of strongly lensed quasars. The mission had its first public data release in September 2016 and is scheduled to have the next and much more comprehensive one in April 2018. Here we briefly review the capabilities and current results of the mission. Gaia's unique contributions to the studies of quasars are already being published, a highlight being a discovery of a number of quasars with optical jets.

  20. Marine Biology

    Science.gov (United States)

    Dewees, Christopher M.; Hooper, Jon K.

    1976-01-01

    A variety of informational material for a course in marine biology or oceanology at the secondary level is presented. Among the topics discussed are: food webs and pyramids, planktonic blooms, marine life, plankton nets, food chains, phytoplankton, zooplankton, larval plankton and filter feeders. (BT)

  1. Mesoscopic biology

    Indian Academy of Sciences (India)

    Abstract. In this paper we present a qualitative outlook of mesoscopic biology where the typical length scale is of the order of nanometers and the energy scales comparable to thermal energy. Novel biomolecular machines, governed by coded information at the level of DNA and proteins, operate at these length scales in ...

  2. Scaffolded biology.

    Science.gov (United States)

    Minelli, Alessandro

    2016-09-01

    Descriptions and interpretations of the natural world are dominated by dichotomies such as organism vs. environment, nature vs. nurture, genetic vs. epigenetic, but in the last couple of decades strong dissatisfaction with those partitions has been repeatedly voiced and a number of alternative perspectives have been suggested, from perspectives such as Dawkins' extended phenotype, Turner's extended organism, Oyama's Developmental Systems Theory and Odling-Smee's niche construction theory. Last in time is the description of biological phenomena in terms of hybrids between an organism (scaffolded system) and a living or non-living scaffold, forming unit systems to study processes such as reproduction and development. As scaffold, eventually, we can define any resource used by the biological system, especially in development and reproduction, without incorporating it as happens in the case of resources fueling metabolism. Addressing biological systems as functionally scaffolded systems may help pointing to functional relationships that can impart temporal marking to the developmental process and thus explain its irreversibility; revisiting the boundary between development and metabolism and also regeneration phenomena, by suggesting a conceptual framework within which to investigate phenomena of regular hypermorphic regeneration such as characteristic of deer antlers; fixing a periodization of development in terms of the times at which a scaffolding relationship begins or is terminated; and promoting plant galls to legitimate study objects of developmental biology.

  3. Biological digestion

    International Nuclear Information System (INIS)

    Rosevear, A.

    1988-01-01

    This paper discusses the biological degradation of non-radioactive organic material occurring in radioactive wastes. The biochemical steps are often performed using microbes or isolated enzymes in combination with chemical steps and the aim is to oxidise the carbon, hydrogen, nitrogen and sulphur to their respective oxides. (U.K.)

  4. Biology Notes.

    Science.gov (United States)

    School Science Review, 1981

    1981-01-01

    Outlines a variety of laboratory procedures, techniques, and materials including construction of a survey frame for field biology, a simple tidal system, isolation and applications of plant protoplasts, tropisms, teaching lung structure, and a key to statistical methods for biologists. (DS)

  5. Exploring Cognition Using Software Defined Radios for NASA Missions

    Science.gov (United States)

    Mortensen, Dale J.; Reinhart, Richard C.

    2016-01-01

    NASA missions typically operate using a communication infrastructure that requires significant schedule planning with limited flexibility when the needs of the mission change. Parameters such as modulation, coding scheme, frequency, and data rate are fixed for the life of the mission. This is due to antiquated hardware and software for both the space and ground assets and a very complex set of mission profiles. Automated techniques in place by commercial telecommunication companies are being explored by NASA to determine their usability by NASA to reduce cost and increase science return. Adding cognition the ability to learn from past decisions and adjust behavior is also being investigated. Software Defined Radios are an ideal way to implement cognitive concepts. Cognition can be considered in many different aspects of the communication system. Radio functions, such as frequency, modulation, data rate, coding and filters can be adjusted based on measurements of signal degradation. Data delivery mechanisms and route changes based on past successes and failures can be made to more efficiently deliver the data to the end user. Automated antenna pointing can be added to improve gain, coverage, or adjust the target. Scheduling improvements and automation to reduce the dependence on humans provide more flexible capabilities. The Cognitive Communications project, funded by the Space Communication and Navigation Program, is exploring these concepts and using the SCaN Testbed on board the International Space Station to implement them as they evolve. The SCaN Testbed contains three Software Defined Radios and a flight computer. These four computing platforms, along with a tracking antenna system and the supporting ground infrastructure, will be used to implement various concepts in a system similar to those used by missions. Multiple universities and SBIR companies are supporting this investigation. This paper will describe the cognitive system ideas under consideration and

  6. Low Energy Mission Planning Toolbox, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Low Energy Mission Planning Toolbox is designed to significantly reduce the resources and time spent on designing missions in multi-body gravitational...

  7. IceBridge Mission Flight Reports

    Data.gov (United States)

    National Aeronautics and Space Administration — The IceBridge Mission Flight Reports data set contains flight reports from NASA Operation IceBridge Greenland, Arctic, Antarctic, and Alaska missions. Flight reports...

  8. ASTER: A Brazilian Mission to an Asteroid.

    Science.gov (United States)

    Winter, O. C.; Macau, E. E. N.; de Campos Velho, H.; Carruba, V.

    2012-05-01

    The first Brazilian mission to an asteroid is being planned. The target is the asteroid 2001 SN263, which has a NEA orbit of class AMOR. The mission is scheduled to be launched in 2015, reaching the asteroid in 2019.

  9. Multi-Mission SDR, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Wireless transceivers used for NASA space missions have traditionally been highly custom and mission specific. Programs such as the GRC Space Transceiver Radio...

  10. The evolution of wireless video transmission technology for surveillance missions

    Science.gov (United States)

    Durso, Christopher M.; McCulley, Eric

    2012-06-01

    Covert and overt video collection systems as well as tactical unmanned aerial vehicles (UAV's) and unmanned ground vehicles (UGV's) can deliver real-time video intelligence direct from sensor systems to command staff providing unprecedented situational awareness and tactical advantage. Today's tactical video communications system must be secure, compact, lightweight, and fieldable in quick reaction scenarios. Four main technology implementations can be identified with the evolutionary development of wireless video transmission systems. Analog FM led to single carrier digital modulation, which gave way to multi-carrier orthogonal modulation. Each of these systems is currently in use today. Depending on the operating environment and size, weight, and power limitations, a system designer may choose one over another to support tactical video collection missions.

  11. [History of the Strasbourg Society of Biology].

    Science.gov (United States)

    Antony, Pierre; Romier, Christophe; Mantz, Jean-Marie

    2017-01-01

    The Society of Biology of Strasbourg (SBS) is a learned society that was created in 1919 based on the model of the Society of Biology of which it is a subsidiary. Like its Parisian colleague, SBS aims at diffusing and promoting scientific knowledge in biology. To achieve this goal, SBS initiated since its creation a dialogue interface between researchers in biology and physicians, and more recently with other scientific disciplines, industry and the civil society. At the dawn of its first century, the Society of Biology of Strasbourg must continue to reinvent itself to pursue its development and to fulfil its mission of sharing scientific knowledge. This work continues in strong collaboration with our partners that share with SBS the willingness to foster excellence in biological research in Strasbourg, its region and beyond. © Société de Biologie, 2017.

  12. Mitigating Adverse Effects of a Human Mission on Possible Martian Indigenous Ecosystems

    Science.gov (United States)

    Lupisella, M. L.

    2000-07-01

    Although human beings are, by most standards, the most capable agents to search for and detect extraterrestrial life, we are also potentially the most harmful. While there has been substantial work regarding forward contamination with respect to robotic missions, the issue of potential adverse effects on possible indigenous Martian ecosystems, such as biological contamination, due to a human mission has remained relatively unexplored and may require our attention now as this presentation will try to demonstrate by exploring some of the relevant scientific questions, mission planning challenges, and policy issues. An informal, high-level mission planning decision tree will be discussed and is included as the next page of this abstract. Some of the questions to be considered are: (1) To what extent could contamination due to a human presence compromise possible indigenous life forms? (2) To what extent can we control contamination? For example, will it be local or global? (3) What are the criteria for assessing the biological status of Mars, both regionally and globally? For example, can we adequately extrapolate from a few strategic missions such as sample return missions? (4) What should our policies be regarding our mission planning and possible interaction with what are likely to be microbial forms of extraterrestrial life? (5) Central to the science and mission planning issues is the role and applicability of terrestrial analogs, such as Lake Vostok for assessing drilling issues, and modeling techniques. Central to many of the policy aspects are scientific value, international law, public concern, and ethics. Exploring this overall issue responsibly requires an examination of all these aspects and how they interrelate. A chart is included, titled 'Mission Planning Decision Tree for Mitigating Adverse Effects to Possible Indigenous Martian Ecosystems due to a Human Mission'. It outlines what questions scientists should ask and answer before sending humans to Mars.

  13. SWARM - An earth Observation Mission investigating Geospace

    DEFF Research Database (Denmark)

    Friis-Christensen, Eigil; Lühr, H.; Knudsen, D.

    2008-01-01

    The Swarm mission was selected as the 5th mission in ESA's Earth Explorer Programme in 2004. This mission aims at measuring the Earth's magnetic field with unprecedented accuracy. This will be done by a constellation of three satellites, where two will fly at lower altitude, measuring the gradient...... of the Swarm science objectives, the mission concept, the scientific instrumentation, and the expected contribution to the ILWS programme will be summarized. (C) 2007 Published by Elsevier Ltd on behalf of COSPAR....

  14. Science Mission Definition Studies for TROPIX

    Science.gov (United States)

    Fennell, J. F.

    1997-01-01

    This document summarizes the results of mission definition studies for solar electric propulsion missions that have been carried out over the last approximately three years. The major output from the studies has been two proposals which were submitted to NASA in response to Announcements of Opportunity for missions and an ongoing Global Magnetospheric Dynamics mission study. The bulk of this report consists of copies of the proposals and preliminary materials from the GMD study that will be completed in the coming months.

  15. CHEOPS: A transit photometry mission for ESA's small mission programme

    Directory of Open Access Journals (Sweden)

    Queloz D.

    2013-04-01

    Full Text Available Ground based radial velocity (RV searches continue to discover exoplanets below Neptune mass down to Earth mass. Furthermore, ground based transit searches now reach milli-mag photometric precision and can discover Neptune size planets around bright stars. These searches will find exoplanets around bright stars anywhere on the sky, their discoveries representing prime science targets for further study due to the proximity and brightness of their host stars. A mission for transit follow-up measurements of these prime targets is currently lacking. The first ESA S-class mission CHEOPS (CHaracterizing ExoPlanet Satellite will fill this gap. It will perform ultra-high precision photometric monitoring of selected bright target stars almost anywhere on the sky with sufficient precision to detect Earth sized transits. It will be able to detect transits of RV-planets by photometric monitoring if the geometric configuration results in a transit. For Hot Neptunes discovered from the ground, CHEOPS will be able to improve the transit light curve so that the radius can be determined precisely. Because of the host stars' brightness, high precision RV measurements will be possible for all targets. All planets observed in transit by CHEOPS will be validated and their masses will be known. This will provide valuable data for constraining the mass-radius relation of exoplanets, especially in the Neptune-mass regime. During the planned 3.5 year mission, about 500 targets will be observed. There will be 20% of open time available for the community to develop new science programmes.

  16. Bottom-up synthetic biology: modular design for making artificial platelets

    Science.gov (United States)

    Majumder, Sagardip; Liu, Allen P.

    2018-01-01

    Engineering artificial cells to mimic one or multiple fundamental cell biological functions is an emerging area of synthetic biology. Reconstituting functional modules from biological components in vitro is a challenging yet an important essence of bottom-up synthetic biology. Here we describe the concept of building artificial platelets using bottom-up synthetic biology and the four functional modules that together could enable such an ambitious effort.

  17. PRIMA Platform capability for satellite missions in LEO and MEO (SAR, Optical, GNSS, TLC, etc.)

    Science.gov (United States)

    Logue, T.; L'Abbate, M.

    2016-12-01

    PRIMA (Piattaforma Riconfigurabile Italiana Multi Applicativa) is a multi-mission 3-axis stabilized Platform developed by Thales Alenia Space Italia under ASI contract.PRIMA is designed to operate for a wide variety of applications from LEO, MEO up to GEO and for different classes of satellites Platform Family. It has an extensive heritage in flight heritage (LEO and MEO Satellites already fully operational) in which it has successfully demonstrated the flexibility of use, low management costs and the ability to adapt to changing operational conditions.The flexibility and modularity of PRIMA provides unique capability to satisfy different Payload design and mission requirements, thanks to the utilization of recurrent adaptable modules (Service Module-SVM, Propulsion Module-PPM, Payload Module-PLM) to obtain mission dependent configuration. PRIMA product line development is continuously progressing, and is based on state of art technology, modular architecture and an Integrated Avionics. The aim is to maintain and extent multi-mission capabilities to operate in different environments (LEO to GEO) with different payloads (SAR, Optical, GNSS, TLC, etc.). The design is compatible with a wide range of European and US equipment suppliers, thus maximising cooperation opportunity. Evolution activities are mainly focused on the following areas: Structure: to enable Spacecraft configurations for multiple launch; Thermal Control: to guarantee thermal limits for new missions, more demanding in terms of environment and payload; Electrical: to cope with higher power demand (e.g. electrical propulsion, wide range of payloads, etc.) considering orbital environment (e.g. lighting condition); Avionics : AOCS solutions optimized on mission (LEO observation driven by agility and pointing, agility not a driver for GEO). Use of sensors and actuators tailored for specific mission and related environments. Optimised Propulsion control. Data Handling, SW and FDIR mission customization

  18. Telecentre Network Startup : Bangladesh - Mission 2011 | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The second generation of telecentres has seen the emergence of national-level networks in various parts of the word including the Ugandan Telecentre Network, Mission 2007 in India and Mission Swaabhimaan in Nepal. Telecentre stakeholders in Bangladesh would like to replicate the methodology used in Mission 2007, ...

  19. Mechanical design of the Mars Pathfinder mission

    Science.gov (United States)

    Eisen, Howard Jay; Buck, Carl W.; Gillis-Smith, Greg R.; Umland, Jeffrey W.

    1997-01-01

    The Mars Pathfinder mission and the Sojourner rover is reported on, with emphasis on the various mission steps and the performance of the technologies involved. The mechanical design of mission hardware was critical to the success of the entry sequence and the landing operations. The various mechanisms employed are considered.

  20. Integrated Modular Teaching of Human Biology for Primary Care Practitioners

    Science.gov (United States)

    Glasgow, Michael S.

    1977-01-01

    Describes the use of integrated modular teaching of the human biology component of the Health Associate Program at Johns Hopkins University, where the goal is to develop an understanding of the sciences as applied to primary care. Discussion covers the module sequence, the human biology faculty, goals of the human biology faculty, laboratory…

  1. Airborne Oceanographic Lidar (AOL) flight mission participation

    Science.gov (United States)

    Hoge, F. E.

    From February 1986 to the present, the AOL participated in six interagency flight missions. (1) Shelf Edge Exchange Processes (SEEP II) (Department of Energy). The SEEP experiments are designed to assess the assimilative capacity of the Continental Shelf to absorb the energy by-products introduced into the near-shore ocean environment from coastal communities and marine activities such as energy production plants and offshore oil operations. (2) BIOWATT II (Office of Naval Research). The major objective of this study was to provide a better understanding of the relationships between ocean physics, biology, bioluminescence, and optics in oligotrophic portions of the Atlantic Ocean. (3) Fall Experiment (FLEX) (Department of Energy). The FLEX studies were designed to determine the fate of low salinity water in the coastal boundary zone that is advected south towards the Florida coast during autumn. (4) Greenland Sea and Icelandic Marine Biological Experiments (NASA). The investigations were designed to evaluate the distribution of surface layer chlorophyll in the Greeland Sea and in the coastal waters in the vicinity of Iceland. (5) Submerged Oceanic Scattering Layer Experiment (Naval Ocean Systems Center). This flight experiment demonstrated for the first time the feasibility of detecting and metrically measuring the depth to submerged layers of particulate matter in the shelf break region and in the inner coastal zone. (6) Microbial Exchanges and Coupling in Coastal Atlantic Systems (National Science Foundation). This investigation was designed to study the transportation and fate of particulates in coastal waters and in particular the Chesapeake Bay/coastal Atlantic Ocean. Shortly after the conduct of the flight experiments, airborne laser-induced chlorophyll a and phycoerythrin fluorescence data, as well as sea surface temperature and airborne expendable bathythermograph water column temperature profiles are supplied to cooperating institutions.

  2. Planned Environmental Microbiology Aspects of Future Lunar and Mars Missions

    Science.gov (United States)

    Ott, C. Mark; Castro, Victoria A.; Pierson, Duane L.

    2006-01-01

    With the establishment of the Constellation Program, NASA has initiated efforts designed similar to the Apollo Program to return to the moon and subsequently travel to Mars. Early lunar sorties will take 4 crewmembers to the moon for 4 to 7 days. Later missions will increase in duration up to 6 months as a lunar habitat is constructed. These missions and vehicle designs are the forerunners of further missions destined for human exploration of Mars. Throughout the planning and design process, lessons learned from the International Space Station (ISS) and past programs will be implemented toward future exploration goals. The standards and requirements for these missions will vary depending on life support systems, mission duration, crew activities, and payloads. From a microbiological perspective, preventative measures will remain the primary techniques to mitigate microbial risk. Thus, most of the effort will focus on stringent preflight monitoring requirements and engineering controls designed into the vehicle, such as HEPA air filters. Due to volume constraints in the CEV, in-flight monitoring will be limited for short-duration missions to the measurement of biocide concentration for water potability. Once long-duration habitation begins on the lunar surface, a more extensive environmental monitoring plan will be initiated. However, limited in-flight volume constraints and the inability to return samples to Earth will increase the need for crew capabilities in determining the nature of contamination problems and method of remediation. In addition, limited shelf life of current monitoring hardware consumables and limited capabilities to dispose of biohazardous trash will drive flight hardware toward non-culture based methodologies, such as hardware that rapidly distinguishes biotic versus abiotic surface contamination. As missions progress to Mars, environmental systems will depend heavily on regeneration of air and water and biological waste remediation and

  3. Biological radioprotector

    International Nuclear Information System (INIS)

    Stefanescu, Ioan; Titescu, Gheorghe; Tamaian, Radu; Haulica, Ion; Bild, Walther

    2002-01-01

    According to the patent description, the biological radioprotector is deuterium depleted water, DDW, produced by vacuum distillation with an isotopic content lower than natural value. It appears as such or in a mixture with natural water and carbon dioxide. It can be used for preventing and reducing the ionizing radiation effects upon humans or animal organisms, exposed therapeutically, professionally or accidentally to radiation. The most significant advantage of using DDW as biological radioprotector results from its way of administration. Indeed no one of the radioprotectors currently used today can be orally administrated, what reduces the patients' compliance to prophylactic administrations. The biological radioprotector is an unnoxious product obtained from natural water, which can be administrated as food additive instead of drinking water. Dose modification factor is according to initial estimates around 1.9, what is a remarkable feature when one takes into account that the product is toxicity-free and side effect-free and can be administrated prophylactically as a food additive. A net radioprotective action of the deuterium depletion was evidenced experimentally in laboratory animals (rats) hydrated with DDW of 30 ppm D/(D+H) concentration as compared with normally hydrated control animals. Knowing the effects of irradiation and mechanisms of the acute radiation disease as well as the effects of administration of radiomimetic chemicals upon cellular lines of fast cell division, it appears that the effects of administrating DDW result from stimulation of the immunity system. In conclusion, the biological radioprotector DDW presents the following advantages: - it is obtained from natural products without toxicity; - it is easy to be administrated as a food additive, replacing the drinking water; - besides radioprotective effects, the product has also immunostimulative and antitumoral effects

  4. Crusts: biological

    Science.gov (United States)

    Belnap, Jayne; Elias, Scott A.

    2013-01-01

    Biological soil crusts, a community of cyanobacteria, lichens, mosses, and fungi, are an essential part of dryland ecosystems. They are critical in the stabilization of soils, protecting them from wind and water erosion. Similarly, these soil surface communities also stabilized soils on early Earth, allowing vascular plants to establish. They contribute nitrogen and carbon to otherwise relatively infertile dryland soils, and have a strong influence on hydrologic cycles. Their presence can also influence vascular plant establishment and nutrition.

  5. The Ionospheric Connection Explorer Mission: Mission Goals and Design

    Science.gov (United States)

    Immel, T. J.; England, S. L.; Mende, S. B.; Heelis, R. A.; Englert, C. R.; Edelstein, J.; Frey, H. U.; Korpela, E. J.; Taylor, E. R.; Craig, W. W.; Harris, S. E.; Bester, M.; Bust, G. S.; Crowley, G.; Forbes, J. M.; Gérard, J.-C.; Harlander, J. M.; Huba, J. D.; Hubert, B.; Kamalabadi, F.; Makela, J. J.; Maute, A. I.; Meier, R. R.; Raftery, C.; Rochus, P.; Siegmund, O. H. W.; Stephan, A. W.; Swenson, G. R.; Frey, S.; Hysell, D. L.; Saito, A.; Rider, K. A.; Sirk, M. M.

    2018-02-01

    The Ionospheric Connection Explorer, or ICON, is a new NASA Explorer mission that will explore the boundary between Earth and space to understand the physical connection between our world and our space environment. This connection is made in the ionosphere, which has long been known to exhibit variability associated with the sun and solar wind. However, it has been recognized in the 21st century that equally significant changes in ionospheric conditions are apparently associated with energy and momentum propagating upward from our own atmosphere. ICON's goal is to weigh the competing impacts of these two drivers as they influence our space environment. Here we describe the specific science objectives that address this goal, as well as the means by which they will be achieved. The instruments selected, the overall performance requirements of the science payload and the operational requirements are also described. ICON's development began in 2013 and the mission is on track for launch in 2018. ICON is developed and managed by the Space Sciences Laboratory at the University of California, Berkeley, with key contributions from several partner institutions.

  6. Marine biology

    International Nuclear Information System (INIS)

    Thurman, H.V.; Webber, H.H.

    1984-01-01

    This book discusses both taxonomic and ecological topics on marine biology. Full coverage of marine organisms of all five kingdoms is provided, along with interesting and thorough discussion of all major marine habitats. Organization into six major parts allows flexibility. It also provides insight into important topics such as disposal of nuclear waste at sea, the idea that life began on the ocean floor, and how whales, krill, and people interact. A full-color photo chapter reviews questions, and exercises. The contents are: an overview marine biology: fundamental concepts/investigating life in the ocean; the physical ocean, the ocean floor, the nature of water, the nature and motion of ocean water; general ecology, conditions for life in the sea, biological productivity and energy transfer; marine organisms; monera, protista, mycota and metaphyta; the smaller marine animals, the large animals marine habitats, the intertidal zone/benthos of the continental shelf, the photic zone, the deep ocean, the ocean under stress, marine pollution, appendix a: the metric system and conversion factors/ appendix b: prefixes and suffixes/ appendix c: taxonomic classification of common marine organisms, and glossary, and index

  7. Orion European Service Module (ESM) Development, Integration and Qualification Status

    Science.gov (United States)

    Berthe, Philippe; Over, Ann P.; Picardo, Michelle; Byers, Anthony W.

    2017-01-01

    ESA and the European Industry are supplying the European Service Module for Orion. An overview of the system and subsystem configuration of the Orion European Service Module (ESM) as designed and built for the EM-1 mission is provided as well as an outline of its development, assembly, integration and verification process performed by ESA and NASA in coordination with their respective Industrial prime contractors, Airbus Defence and Space and Lockheed Martin.

  8. Mission Design of the Dutch-Chinese FAST Micro-Satellite Mission

    NARCIS (Netherlands)

    Maessen, D.C.; Guo, J.; Gill, E.; Laan, E.; Moon, S.; Zheng, G.T.

    2009-01-01

    The paper treats the mission design for the Dutch-Chinese FAST (Formation for Atmospheric Science and Technology demonstration) mission. The space segment of the 2.5 year mission consists out of two formation flying micro-satellites. During the mission, new technologies will be demonstrated and,

  9. Mission of the month: Uganda.

    Science.gov (United States)

    Snead, B

    1988-04-01

    US Agency for International Development (USAID) assistance to Uganda has been interrupted several times due to Uganda's turbulent history since independence. Mission Director Richard Podol explains that because USAID is not a major donor to Uganda, an effort is made to maximize effectiveness by being cautious about how agency money is spent. USAID looks for critical gaps that are not being filled by other donor programs yet are essential to the development of Uganda at present and in the future. 1 such area is export promotion. Another area is macroeconomic reform. Agricultural rehabilitation is a major factor in the mission's strategy to restore Uganda prosperity. USAID has a package of interrelated projects that work to increase agricultural production and improve processing and marketing, all supported by appropriate economic policies. In 1983, USAID began to fund the Manpower for Agriculture Development (MFAD) Project to assist the MInistry of Agriculture and Makerere University in strengthening their agricultural research and training capabilities. Also designed to increase food production is USAID's 6-year and $20 million Cooperative Agriculture and Agribusiness Support project. IN the health sector, USAID's Family Health Initiatives project works cooperatively with US and international organizations in supporting the MInistry of Health and Ugandan private organizations in their efforts to implement family planning policies and programs. The missions' oral rehydration project is being implemented throughout Uganda to reduce child mortality and severe cases of childhood illness caused by diarrheal diseases. The US in 1986 made pledges toward the budget for UGanda's Acquired Immune Deficiency Syndrome (AIDS) program. Podol maintains that while there has been significant economic and political progress, the primary issue continues to be political, i.e,, can full peace be restored to Uganda.

  10. Retrieving Baseflow from SWOT Mission

    Science.gov (United States)

    Baratelli, F.; Flipo, N.; Biancamaria, S.; Rivière, A.

    2017-12-01

    The quantification of aquifer contribution to river discharge is of primary importance to evaluate the impact of climatic and anthropogenic stresses on the availability of water resources. Several baseflow estimation methods require river discharge measurements, which can be difficult to obtain at high spatio-temporal resolution for large scale basins. The SWOT satellite mission will provide discharge estimations for large rivers (50 - 100 m wide) even in remote basins. The frequency of these estimations depends on the position and ranges from zero to four values in the 21-days satellite cycle. This work aims at answering the following question: can baseflow be estimated from SWOT observations during the mission lifetime? An algorithm based on hydrograph separation by Chapman's filter was developed to automatically estimate the baseflow in a river network at regional or larger scale (> 10000 km2). The algorithm was first applied using the discharge time series simulated at daily time step by a coupled hydrological-hydrogeological model to obtain the reference baseflow estimations. The same algorithm is then forced with discharge time series sampled at SWOT observation frequency. The methodology was applied to the Seine River basin (65000 km2, France). The results show that the average baseflow is estimated with good accuracy for all the reaches which are observed at least once per cycle (relative bias less than 4%). The time evolution of baseflow is also rather well retrieved, with a Nash coefficient which is more than 0.7 for 94% of the network length. This work provides new potential for the SWOT mission in terms of global hydrological analysis.

  11. Project Prometheus and Future Entry Probe Missions

    Science.gov (United States)

    Spilker, Thomas R.

    2005-01-01

    A viewgraph presentation on project Prometheus and future entry probe missions is shown. The topics include: 1) What Is Project Prometheus?; 2) What Capabilities Can Project Prometheus Offer? What Mission Types Are Being Considered?; 3) Jupiter Icy Moons Orbiter (JIMO); 4) How Are Mission Opportunities Changing?; 5) Missions Of Interest a Year Ago; 6) Missions Now Being Considered For Further Study; 7) Galileo-Style (Conventional) Probe Delivery; 8) Galileo-Style Probe Support; 9) Conventional Delivery and Support of Multiple Probes; 10) How Entry Probe Delivery From an NEP Vehicle Is Different; and 11) Concluding Remarks.

  12. Bion 11 mission: primate experiments

    Science.gov (United States)

    Ilyin, E. A.; Korolkov, V. I.; Skidmore, M. G.; Viso, M.; Kozlovskaya, I. B.; Grindeland, R. E.; Lapin, B. A.; Gordeev, Y. V.; Krotov, V. P.; Fanton, J. W.; hide

    2000-01-01

    A summary is provided of the major operations required to conduct the wide range of primate experiments on the Bion 11 mission, which flew for 14 days beginning December 24, 1996. Information is given on preflight preparations, including flight candidate selection and training; attachment and implantation of bioinstrumentation; flight and ground experiment designs; onboard life support and test systems; ground and flight health monitoring; flight monkey selection and transport to the launch site; inflight procedures and data collection; postflight examinations and experiments; and assessment of results.

  13. Draft 1988 mission plan amendment

    International Nuclear Information System (INIS)

    1988-06-01

    This draft 1988 amendment to the Mission Plan for the Civilian Radioactive Waste Management Program has been prepared by the US Department of Energy (DOE). The purpose is to inform the Congress of the DOE's plans for implementing the provisions of the Nuclear Waste Policy Amendments Act of 1987 (P.L. 100-203) for the Civilian Radioactive Waste Management Program. This document is being submitted in draft form to Federal agencies, states, previously affected Indian Tribes, affected units of local government, and the public. After the consideration of comments, this amendment will be revised as appropriate and submitted to the Congress. 39 refs., 7 figs., 4 tabs

  14. GPS test range mission planning

    Science.gov (United States)

    Roberts, Iris P.; Hancock, Thomas P.

    The principal features of the Test Range User Mission Planner (TRUMP), a PC-resident tool designed to aid in deploying and utilizing GPS-based test range assets, are reviewed. TRUMP features time history plots of time-space-position information (TSPI); performance based on a dynamic GPS/inertial system simulation; time history plots of TSPI data link connectivity; digital terrain elevation data maps with user-defined cultural features; and two-dimensional coverage plots of ground-based test range assets. Some functions to be added during the next development phase are discussed.

  15. Kepler planet-detection mission

    DEFF Research Database (Denmark)

    Borucki...[], William J.; Koch, David; Buchhave, Lars C. Astrup

    2010-01-01

    The Kepler mission was designed to determine the frequency of Earth-sized planets in and near the habitable zone of Sun-like stars. The habitable zone is the region where planetary temperatures are suitable for water to exist on a planet’s surface. During the first 6 weeks of observations, Kepler...... is one of the lowest-density planets (~0.17 gram per cubic centimeter) yet detected. Kepler-5b, -6b, and -8b confirm the existence of planets with densities lower than those predicted for gas giant planets....

  16. Magnetic Satellite Missions and Data

    DEFF Research Database (Denmark)

    Olsen, Nils; Kotsiaros, Stavros

    2011-01-01

    Although the first satellite observations of the Earth’s magnetic field were already taken more than 50 years ago, continuous geomagnetic measurements from space are only available since 1999. The unprecedented time-space coverage of this recent data set opened revolutionary new possibilities...... for exploring the Earth’s magnetic field from space. In this chapter we discuss characteristics of satellites measuring the geomagnetic field and report on past, present and upcoming magnetic satellite missions. We conclude with some basics about space magnetic gradiometry as a possible path for future...... exploration of Earth’s magnetic field with satellites....

  17. La Chalupa mission No. 12. Final report

    International Nuclear Information System (INIS)

    Castro, R.; Davis, P.H.; Kimmel, J.J.; Purcell, T.W.; Rivera, J.A.

    1975-03-01

    The Islote area on the north coast of Puerto Rico is under consideration as a nuclear power plant site. The Puerto Rico Nuclear Center (PRNC) has been contracted to collect both physical and biological baseline data on the marine environment at this site. The underwater habitat, La Chalupa, was made available for 16 days in May and June 1974. This facility allowed PRNC staff an opportunity to evaluate the ecology of the area from a different perspective, itioned approximately 900 meters offshore in 22 meters of water. Within this area, different habitats were determined, observations were made, and samples were collected. The relative distribution of the dominant benthic flora and fauna was studied. The ecological relationships of several commercially valuable organisms such as conch, lobster, and crabs were investigated. Several physical parameters (sedimentation, sediment transport, and currents) were considered in relation to animal distribution. Most fishes could be observed and their abundance and importance in the area estimated. Data gathered during the mission provides informationa in the form of: identification of populations and major species near the bottom; determination of changes which might occur in the populations as a result of tidal influences or time of day; and determination of a crude idea of productivity in the study area by use of cell counts, chlorophyll measurements, and dark-light bottle studies. Evaluation of La Chalupa tool is presented. Tables are presented of species lists of benthic organisms, fishes, and phytoplankton. (U.S.)

  18. Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate.

    Science.gov (United States)

    Aikawa, Katsuji; Asano, Moriteru; Ono, Koji; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Kandori, Hitoshi; Hara, Takahito; Morimoto, Megumi; Santou, Takashi; Yamaoka, Masuo; Nakayama, Masaharu; Hasuoka, Atsushi

    2017-07-01

    We previously reported that 4-(pyrrolidin-1-yl)benzonitrile derivative 1b was a selective androgen receptor modulator (SARM) that exhibited anabolic effects on organs such as muscles and the central nervous system (CNS), but neutral effects on the prostate. From further modification, we identified that 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2a showed strong AR binding affinity with improved metabolic stabilities. Based on these results, we tried to enhance the AR agonistic activities by modifying the substituents of the 5-oxopyrrolidine ring. As a consequence, we found that 4-[(2S,3S)-2-ethyl-3-hydroxy-5-oxopyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile (2f) had ideal SARM profiles in Hershberger assay and sexual behavior induction assay. Furthermore, 2f showed good pharmacokinetic profiles in rats, dogs, monkeys, excellent nuclear selectivity and acceptable toxicological profiles. We also determined its binding mode by obtaining the co-crystal structures with AR. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Integrative radiation systems biology

    International Nuclear Information System (INIS)

    Unger, Kristian

    2014-01-01

    Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost parameter influencing this ratio is radiation sensitivity and its modulation towards a more efficient killing of tumour cells and a better preservation of normal tissue at the same time is the overall aim of modern therapy schemas. Nevertheless, this requires a deep understanding of the molecular mechanisms of radiation sensitivity in order to identify its key players as potential therapeutic targets. Moreover, the success of conventional approaches that tried to statistically associate altered radiation sensitivity with any molecular phenotype such as gene expression proofed to be somewhat limited since the number of clinically used targets is rather sparse. However, currently a paradigm shift is taking place from pure frequentistic association analysis to the rather holistic systems biology approach that seeks to mathematically model the system to be investigated and to allow the prediction of an altered phenotype as the function of one single or a signature of biomarkers. Integrative systems biology also considers the data from different molecular levels such as the genome, transcriptome or proteome in order to partially or fully comprehend the causal chain of molecular mechanisms. An example for the application of this concept currently carried out at the Clinical Cooperation Group “Personalized Radiotherapy in Head and Neck Cancer” of the Helmholtz-Zentrum München and the LMU Munich is described. This review article strives for providing a compact overview on the state of the art of systems biology, its actual challenges, potential applications, chances and limitations in radiation oncology research working towards improved personalised therapy concepts using this relatively new methodology

  20. Infusion of innovative technologies for mission operations

    Science.gov (United States)

    Donati, Alessandro

    2010-11-01

    The Advanced Mission Concepts and Technologies Office (Mission Technologies Office, MTO for short) at the European Space Operations Centre (ESOC) of ESA is entrusted with research and development of innovative mission operations concepts systems and provides operations support to special projects. Visions of future missions and requests for improvements from currently flying missions are the two major sources of inspiration to conceptualize innovative or improved mission operations processes. They include monitoring and diagnostics, planning and scheduling, resource management and optimization. The newly identified operations concepts are then proved by means of prototypes, built with embedded, enabling technology and deployed as shadow applications in mission operations for an extended validation phase. The technology so far exploited includes informatics, artificial intelligence and operational research branches. Recent outstanding results include artificial intelligence planning and scheduling applications for Mars Express, advanced integrated space weather monitoring system for the Integral space telescope and a suite of growing client applications for MUST (Mission Utilities Support Tools). The research, development and validation activities at the Mission technologies office are performed together with a network of research institutes across Europe. The objective is narrowing the gap between enabling and innovative technology and space mission operations. The paper first addresses samples of technology infusion cases with their lessons learnt. The second part is focused on the process and the methodology used at the Mission technologies office to fulfill its objectives.

  1. Introduction to special section on the Phoenix Mission: Landing Site Characterization Experiments, Mission Overviews, and Expected Science

    Science.gov (United States)

    Smith, P. H.; Tamppari, L.; Arvidson, R. E.; Bass, D.; Blaney, D.; Boynton, W.; Carswell, A.; Catling, D.; Clark, B.; Duck, T.; DeJong, E.; Fisher, D.; Goetz, W.; Gunnlaugsson, P.; Hecht, M.; Hipkin, V.; Hoffman, J.; Hviid, S.; Keller, H.; Kounaves, S.; Lange, C. F.; Lemmon, M.; Madsen, M.; Malin, M.; Markiewicz, W.; Marshall, J.; McKay, C.; Mellon, M.; Michelangeli, D.; Ming, D.; Morris, R.; Renno, N.; Pike, W. T.; Staufer, U.; Stoker, C.; Taylor, P.; Whiteway, J.; Young, S.; Zent, A.

    2008-10-01

    verifying that massive water ice is found near the surface and determining the history of the icy soil by studying the mineralogical, chemical, and microscopic properties of the soil grains, Phoenix will address questions concerning the effects of climate change in the northern plains. A conclusion that unfrozen water has modified the soil naturally leads to speculation as to the biological potential of the soil, another scientific objective of the mission.

  2. Acts for today’s missional church

    Directory of Open Access Journals (Sweden)

    Cornelius (Nelus J.P. Niemandt

    2010-06-01

    Full Text Available This article investigated the challenges associated with being a missional church in an everchanging world and possible patterns to live missionally in new contexts. The need for Christian missions to be radically contextual in facing up to these changes provided the basis for this study to build on the importance of context and the ways in which the early church in Acts reinvented itself continually in facing up to new challenges, opportunities, peoples, cultures and questions. The way in which the faith community emerged as a church when it became aware of its boundary-breaking mission was explored by using the seven phases in the development of the mission of the church, as identified by Bevans and Schroeder in their groundbreaking theology of missions. By reflecting on these seven phases, this article formulated patterns for a missional church.

  3. CLARM: An integrative approach for functional modules discovery

    KAUST Repository

    Salem, Saeed M.

    2011-01-01

    Functional module discovery aims to find well-connected subnetworks which can serve as candidate protein complexes. Advances in High-throughput proteomic technologies have enabled the collection of large amount of interaction data as well as gene expression data. We propose, CLARM, a clustering algorithm that integrates gene expression profiles and protein protein interaction network for biological modules discovery. The main premise is that by enriching the interaction network by adding interactions between genes which are highly co-expressed over a wide range of biological and environmental conditions, we can improve the quality of the discovered modules. Protein protein interactions, known protein complexes, and gene expression profiles for diverse environmental conditions from the yeast Saccharomyces cerevisiae were used for evaluate the biological significance of the reported modules. Our experiments show that the CLARM approach is competitive to wellestablished module discovery methods. Copyright © 2011 ACM.

  4. Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to mars.

    Directory of Open Access Journals (Sweden)

    Mathias Basner

    Full Text Available Behavioral health risks are among the most serious and difficult to mitigate risks of confinement in space craft during long-duration space exploration missions. We report on behavioral and psychological reactions of a multinational crew of 6 healthy males confined in a 550 m(3 chamber for 520 days during the first Earth-based, high-fidelity simulated mission to Mars. Rest-activity of crewmembers was objectively measured throughout the mission with wrist-worn actigraphs. Once weekly throughout the mission crewmembers completed the Beck Depression Inventory-II (BDI-II, Profile of Moods State short form (POMS, conflict questionnaire, the Psychomotor Vigilance Test (PVT-B, and series of visual analogue scales on stress and fatigue. We observed substantial inter-individual differences in the behavioral responses of crewmembers to the prolonged mission confinement and isolation. The crewmember with the highest average POMS total mood disturbance score throughout the mission also reported symptoms of depression in 93% of mission weeks, which reached mild-to-moderate levels in >10% of mission weeks. Conflicts with mission control were reported five times more often than conflicts among crewmembers. Two crewmembers who had the highest ratings of stress and physical exhaustion accounted for 85% of the perceived conflicts. One of them developed a persistent sleep onset insomnia with ratings of poor sleep quality, which resulted in chronic partial sleep deprivation, elevated ratings of daytime tiredness, and frequent deficits in behavioral alertness. Sleep-wake timing was altered in two other crewmembers, beginning in the first few months of the mission and persisting throughout. Two crewmembers showed neither behavioral disturbances nor reports of psychological distress during the 17-month period of mission confinement. These results highlight the importance of identifying behavioral, psychological, and biological markers of characteristics that

  5. Psychological and behavioral changes during confinement in a 520-day simulated interplanetary mission to mars.

    Science.gov (United States)

    Basner, Mathias; Dinges, David F; Mollicone, Daniel J; Savelev, Igor; Ecker, Adrian J; Di Antonio, Adrian; Jones, Christopher W; Hyder, Eric C; Kan, Kevin; Morukov, Boris V; Sutton, Jeffrey P

    2014-01-01

    Behavioral health risks are among the most serious and difficult to mitigate risks of confinement in space craft during long-duration space exploration missions. We report on behavioral and psychological reactions of a multinational crew of 6 healthy males confined in a 550 m(3) chamber for 520 days during the first Earth-based, high-fidelity simulated mission to Mars. Rest-activity of crewmembers was objectively measured throughout the mission with wrist-worn actigraphs. Once weekly throughout the mission crewmembers completed the Beck Depression Inventory-II (BDI-II), Profile of Moods State short form (POMS), conflict questionnaire, the Psychomotor Vigilance Test (PVT-B), and series of visual analogue scales on stress and fatigue. We observed substantial inter-individual differences in the behavioral responses of crewmembers to the prolonged mission confinement and isolation. The crewmember with the highest average POMS total mood disturbance score throughout the mission also reported symptoms of depression in 93% of mission weeks, which reached mild-to-moderate levels in >10% of mission weeks. Conflicts with mission control were reported five times more often than conflicts among crewmembers. Two crewmembers who had the highest ratings of stress and physical exhaustion accounted for 85% of the perceived conflicts. One of them developed a persistent sleep onset insomnia with ratings of poor sleep quality, which resulted in chronic partial sleep deprivation, elevated ratings of daytime tiredness, and frequent deficits in behavioral alertness. Sleep-wake timing was altered in two other crewmembers, beginning in the first few months of the mission and persisting throughout. Two crewmembers showed neither behavioral disturbances nor reports of psychological distress during the 17-month period of mission confinement. These results highlight the importance of identifying behavioral, psychological, and biological markers of characteristics that predispose prospective

  6. Reduced multiplication modules

    Indian Academy of Sciences (India)

    if M is a von Neumann regular module (VNM); i.e., every principal submodule of M is a summand submodule. Also if M is an injective R-module, then M is a VNM. Keywords. Multiplication module; reduced module; minimal prime submodule;. Zariski topology; extremally disconnected. 1. Introduction. In this paper all rings are ...

  7. Visiting the International Space Station - my mission diary

    Science.gov (United States)

    Guidoni, U.

    2001-08-01

    Having been fortunate enough to be the first European Astronaut to visit and live aboard the International Space Station, I would like to share with you my personal diary of this very special trip. Space Shuttle "Endeavour", with an international crew of seven, lifted off from Kennedy Space Center in Florida on 19 April for an 11-day mission, which included the delivery of the European-developed "Raffaello" logistics module to the Station and the attachment of the Station's new 17-metre Canadian Robotic Arm. We returned to Earth, with a landing at Edwards Air Force Base in California, on 1 May. Raffaello had been packed for its outward journey with 10 tons of new Station equipment, including six experiment racks and two storage racks for the US "Destiny" module, as well as supplies for the astronauts and other equipment for future construction and maintenance work. One of my main task during the mission was to oversee the safe unloading of all of the experiments and equipment into the Space Station. I was relieved that the whole exercise went so smoothly and very proud to have been the first astronaut to represent Europe on the International Space Station.

  8. Visiting the International Space Station--my mission diary.

    Science.gov (United States)

    Guidoni, G

    2001-08-01

    Having been fortunate enough to be the first European Astronaut to visit and live aboard the International Space Station, I would like to share with you my personal diary of this very special trip. Space Shuttle 'Endeavour', with an international crew of seven, lifted off from Kennedy Space Center in Florida on 19 April for an 11-day mission, which included the delivery of the European-developed 'Raffaello' logistics module to the Station and the attachment of the Station's new 17-metre Canadian Robotic Arm. We returned to Earth, with a landing at Edwards Air Force Base in California, on 1 May. Raffaello had been packed for its outward journey with 10 tons of new Station equipment, including six experiment racks and two storage racks for the US 'Destiny' module, as well as supplies for the astronauts and other equipment for future construction and maintenance work. One of my main tasks during the mission was to oversee the safe unloading of all of the experiments and equipment into the Space Station. I was relieved that the whole exercise went so smoothly and very proud to have been the first astronaut to represent Europe on the International Space Station.

  9. Coded Modulation in C and MATLAB

    Science.gov (United States)

    Hamkins, Jon; Andrews, Kenneth S.

    2011-01-01

    This software, written separately in C and MATLAB as stand-alone packages with equivalent functionality, implements encoders and decoders for a set of nine error-correcting codes and modulators and demodulators for five modulation types. The software can be used as a single program to simulate the performance of such coded modulation. The error-correcting codes implemented are the nine accumulate repeat-4 jagged accumulate (AR4JA) low-density parity-check (LDPC) codes, which have been approved for international standardization by the Consultative Committee for Space Data Systems, and which are scheduled to fly on a series of NASA missions in the Constellation Program. The software implements the encoder and decoder functions, and contains compressed versions of generator and parity-check matrices used in these operations.

  10. FUSE Mission Overview and Status

    Science.gov (United States)

    Sonneborn, G.

    The Far Ultraviolet Spectroscopic Explorer satellite observes light in the 905-1187 Å region with high spectral resolution (λ/Δλ ~ 20,000). FUSE was launched on 24 June 1999 and the early observations have yielded significant results in several areas of galactic and extragalactic astronomy. The sensitivity is sufficient to examine reddened lines of sight within the Milky Way as well as active galactic nuclei and QSOs for absorption line studies of both Milky Way and extragalactic gas clouds. This spectral region contains a number of important scientific diagnostics, including O VI, H I, D I, and the strong electronic transitions of the H2 and HD molecules. The instrument has four coaligned prime-focus telescopes and Rowland spectrographs with microchannel plate detectors. Two channels use Al:LiF coatings for optimum reflectivity from ~ 1000 to 1187 Å and the other two use SiC coatings for optimized throughput between 905 and 1105 Å. The gratings were holographically ruled to largely correct for astigmatism and to minimize scattered light. The detectors have KBr photocathodes and use photon counting to achieve good quantum efficiency with low background signal. The primary mission duration is three years; an extended mission phase is planned. A majority of the observing time is allocated to guest observers. (http://fuse.pha.jhu.edu)

  11. Bangladesh mission sees great benefits.

    Science.gov (United States)

    1998-10-01

    A JOICFP 2-member mission visited Bangladesh during August 9-22 to monitor the progress of cooperative projects in Narsingdhi and Feni districts, implemented by the Family Planning Association of Bangladesh (FPAB), and to discuss the implementation of Postal Savings for International Voluntary Aid (POSIVA) funds. POSIVA is in its 4th year of providing funds to Bangladesh. The Population Reference Bureau's (PRB) Japan Representative joined the mission on a study tour during August 9-17 to directly observe reproductive health and family planning, women's empowerment, and micro-credit at the grassroots level. The representative hopes to raise the Japanese public's awareness of international nongovernmental organization (NGO) partnerships in order to encourage them to help rural populations in developing countries. The offices of the Ministry of Health and Family Welfare, the International Secretariat of Partners in Population and Development, UNFPA, Population Council, OECF, the Japan International Cooperation Agency (JICA), and the Grammin Bank were visited, as well as the project areas of Panchdona and Dhalia Unions of the Integrated Family Development Project. ODA assistance should be strengthened to improve grassroots activities, with a focus upon women's empowerment, maternal and child health, and alleviating poverty through NGOs working together with communities. A project to build capacity in reproductive health in Jessore District is described.

  12. PHOTOGRAMMETRIC MISSION PLANNER FOR RPAS

    Directory of Open Access Journals (Sweden)

    F. Gandor

    2015-08-01

    Full Text Available This paper presents a development of an open-source flight planning tool for Remotely Piloted Aircraft Systems (RPAS that is dedicated to high-precision photogrammetric mapping. This tool contains planning functions that are usually available in professional mapping systems for manned aircrafts as well as new features related to GPS signal masking in complex (e.g. mountainous terrain. The application is based on the open-source Java SDK (Software Development Kit World Wind from NASA that contains the main geospatial components facilitating the development itself. Besides standard planning functions known from other mission planners, we mainly focus on additional features dealing with safety and accuracy, such as GPS quality assessment. The need for the development came as a response for unifying mission planning across different platforms (e.g. rotary or fixed wing operating over terrain of different complexity. A special attention is given to the user interface, that is intuitive to use and cost-effective with respect to computer resources.

  13. Photogrammetric Mission Planner for Rpas

    Science.gov (United States)

    Gandor, F.; Rehak, M.; Skaloud, J.

    2015-08-01

    This paper presents a development of an open-source flight planning tool for Remotely Piloted Aircraft Systems (RPAS) that is dedicated to high-precision photogrammetric mapping. This tool contains planning functions that are usually available in professional mapping systems for manned aircrafts as well as new features related to GPS signal masking in complex (e.g. mountainous) terrain. The application is based on the open-source Java SDK (Software Development Kit) World Wind from NASA that contains the main geospatial components facilitating the development itself. Besides standard planning functions known from other mission planners, we mainly focus on additional features dealing with safety and accuracy, such as GPS quality assessment. The need for the development came as a response for unifying mission planning across different platforms (e.g. rotary or fixed wing) operating over terrain of different complexity. A special attention is given to the user interface, that is intuitive to use and cost-effective with respect to computer resources.

  14. The Extended Mission Rover (EMR)

    Science.gov (United States)

    Shields, W.; Halecki, Anthony; Chung, Manh; Clarke, Ken; Frankle, Kevin; Kassemkhani, Fariba; Kuhlhoff, John; Lenzini, Josh; Lobdell, David; Morgan, Sam

    A key component in ensuring America's status as a leader in the global community is its active pursuit of space exploration. On the twentieth anniversary of Apollo 11, President George Bush challenged the nation to place a man on the moon permanently and to conduct human exploration of Mars in the 21st century. The students of the FAMU/FSU College of Engineering hope to make a significant contribution to this challenge, America's Space Exploration Initiative (SEI), with their participation in the NASA/USRA Advanced Design Program. The project selected by the 1991/1992 Aerospace Design group is the design of an Extended Mission Rover (EMR) for use on the lunar surface. This vehicle will serve as a mobile base to provide future astronauts with a 'shirt-sleeve' living and working environment. Some of the proposed missions are planetary surface exploration, construction and maintenance, hardware setup, and in situ resource experimentation. This vehicle will be put into use in the 2010-2030 time frame.

  15. The Cassini-Huygens mission

    CERN Document Server

    The joint NASA-ESA Cassini-Huygens mission promises to return four (and possibly more) years of unparalleled scientific data from the solar system’s most exotic planet, the ringed, gas giant, Saturn. Larger than Galileo with a much greater communication bandwidth, Cassini can accomplish in a single flyby what Galileo returned in a series of passes. Cassini explores the Saturn environment in three dimensions, using gravity assists to climb out of the equatorial plane to look down on the rings from above, to image the aurora and to study polar magnetospheric processes such as field-aligned currents. Since the radiation belt particle fluxes are much more benign than those at Jupiter, Cassini can more safely explore the inner regions of the magnetosphere. The spacecraft approaches the planet closer than Galileo could, and explores the inner moons and the rings much more thoroughly than was possible at Jupiter. This book is the second volume, in a three volume set, that describes the Cassini/Huygens mission. Thi...

  16. Perfect launch for Space Shuttle Discovery on mission STS-105

    Science.gov (United States)

    2001-01-01

    KENNEDY SPACE CENTER, Fla. -- Smoke billows out from Launch Pad 39A as Space Shuttle Discovery soars into the blue sky on mission STS-105 to the International Space Station. Liftoff occurred at 5:10:14 p.m. EDT on this second launch attempt. Launch countdown activities for the 12-day mission were called off Aug. 9 during the T-9 minute hold due to the high potential for lightning, a thick cloud cover and the potential for showers. Besides the Shuttle crew of four, Discovery carries the Expedition Three crew who will replace Expedition Two on the International Space Station. The mission includes the third flight of an Italian-built Multi-Purpose Logistics Module delivering additional scientific racks, equipment and supplies for the Space Station, and two spacewalks. Part of the payload is the Early Ammonia Servicer (EAS) tank, which will be attached to the Station during the spacewalks. The EAS contains spare ammonia for the Station'''s cooling system. The three-member Expedition Two crew will be returning to Earth aboard Discovery after a five-month stay on the Station.

  17. Bringing Space Science to the Undergraduate Classroom: NASA's USIP Mission

    Science.gov (United States)

    Vassiliadis, D.; Christian, J. A.; Keesee, A. M.; Spencer, E. A.; Gross, J.; Lusk, G. D.

    2015-12-01

    As part of its participation in NASA's Undergraduate Student Instrument Project (USIP), a team of engineering and physics students at West Virginia University (WVU) built a series of sounding rocket and balloon missions. The first rocket and balloon missions were flown near-simultaneously in a campaign on June 26, 2014 (image). The second sounding rocket mission is scheduled for October 5, 2015. Students took a course on space science in spring 2014, and followup courses in physics and aerospace engineering departments have been developed since then. Guest payloads were flown from students affiliated with WV Wesleyan College, NASA's IV&V Facility, and the University of South Alabama. Students specialized in electrical and aerospace engineering, and space physics topics. They interacted regularly with NASA engineers, presented at telecons, and prepared reports. A number of students decided to pursue internships and/or jobs related to space science and technology. Outreach to the campus and broader community included demos and flight projects. The physics payload includes plasma density and temperature measurements using a Langmuir and a triple probe; plasma frequency measurements using a radio sounder (WVU) and an impedance probe (U.S.A); and a magnetometer (WVWC). The aerospace payload includes an IMU swarm, a GPS experiment (with TEC capability); a cubesat communications module (NASA IV&V), and basic flight dynamics. Acknowledgments: staff members at NASA Wallops Flight Facility, and at the Orbital-ATK Rocket Center, WV.

  18. Risk Assessment of Bone Fracture During Space Exploration Missions to the Moon and Mars

    Science.gov (United States)

    Lewandowski, Beth E.; Myers, Jerry G.; Nelson, Emily S.; Griffin, Devon

    2008-01-01

    The possibility of a traumatic bone fracture in space is a concern due to the observed decrease in astronaut bone mineral density (BMD) during spaceflight and because of the physical demands of the mission. The Bone Fracture Risk Module (BFxRM) was developed to quantify the probability of fracture at the femoral neck and lumbar spine during space exploration missions. The BFxRM is scenario-based, providing predictions for specific activities or events during a particular space mission. The key elements of the BFxRM are the mission parameters, the biomechanical loading models, the bone loss and fracture models and the incidence rate of the activity or event. Uncertainties in the model parameters arise due to variations within the population and unknowns associated with the effects of the space environment. Consequently, parameter distributions were used in Monte Carlo simulations to obtain an estimate of fracture probability under real mission scenarios. The model predicts an increase in the probability of fracture as the mission length increases and fracture is more likely in the higher gravitational field of Mars than on the moon. The resulting probability predictions and sensitivity analyses of the BFxRM can be used as an engineering tool for mission operation and resource planning in order to mitigate the risk of bone fracture in space.

  19. Modulational effects in accelerators

    International Nuclear Information System (INIS)

    Satogata, T.

    1997-01-01

    We discuss effects of field modulations in accelerators, specifically those that can be used for operational beam diagnostics and beam halo control. In transverse beam dynamics, combined effects of nonlinear resonances and tune modulations influence diffusion rates with applied tune modulation has been demonstrated. In the longitudinal domain, applied RF phase and voltage modulations provide mechanisms for parasitic halo transport, useful in slow crystal extraction. Experimental experiences with transverse tune and RF modulations are also discussed

  20. Biological biomaterials

    Energy Technology Data Exchange (ETDEWEB)

    Jorge-Herrero, E. [Servicio de Cirugia Experimental. Clinica Puerta de Hierro, Madrid (Spain)

    1997-05-01

    There are a number of situations in which substances of biological origin are employed as biomaterials. Most of them are macromolecules derived from isolated connective tissue or the connective tissue itself in membrane form, in both cases, the tissue can be used in its natural form or be chemically treated. In other cases, certain blood vessels can be chemically pretreated and used as vascular prostheses. Proteins such as albumin, collagen and fibrinogen are employed to coat vascular prostheses. Certain polysaccharides have also been tested for use in controlled drug release systems. Likewise, a number of tissues, such as dura mater, bovine pericardium, procine valves and human valves, are used in the preparation of cardiac prostheses. We also use veins from animals or humans in arterial replacement. In none of these cases are the tissues employed dissimilar to the native tissues as they have been chemically modified, becoming a new bio material with different physical and biochemical properties. In short, we find that natural products are being utilized as biomaterials and must be considered as such; thus, it is necessary to study both their chemicobiological and physicomechanical properties. In the present report, we review the current applications, problems and future prospects of some of these biological biomaterials. (Author) 84 refs.

  1. Nuclear bimodal new vision solar system missions

    International Nuclear Information System (INIS)

    Mondt, J.F.; Zubrin, R.M.

    1996-01-01

    This paper presents an analysis of the potential mission capability using space reactor bimodal systems for planetary missions. Missions of interest include the Main belt asteroids, Jupiter, Saturn, Neptune, and Pluto. The space reactor bimodal system, defined by an Air Force study for Earth orbital missions, provides 10 kWe power, 1000 N thrust, 850 s Isp, with a 1500 kg system mass. Trajectories to the planetary destinations were examined and optimal direct and gravity assisted trajectories were selected. A conceptual design for a spacecraft using the space reactor bimodal system for propulsion and power, that is capable of performing the missions of interest, is defined. End-to-end mission conceptual designs for bimodal orbiter missions to Jupiter and Saturn are described. All missions considered use the Delta 3 class or Atlas 2AS launch vehicles. The space reactor bimodal power and propulsion system offers both; new vision open-quote open-quote constellation close-quote close-quote type missions in which the space reactor bimodal spacecraft acts as a carrier and communication spacecraft for a fleet of microspacecraft deployed at different scientific targets and; conventional missions with only a space reactor bimodal spacecraft and its science payload. copyright 1996 American Institute of Physics

  2. Enabling the First Interstellar Missions

    Science.gov (United States)

    Lubin, P.

    2017-12-01

    All propulsion systems that leave the Earth are based on chemical reactions. Chemical reactions, at best, have an efficiency compared to rest mass of 10-10 (or about 1eV per bond). All the mass in the universe converted to chemical reactions would not propel even a single proton to relativistic speeds. While chemistry will get us to Mars it will not allow interstellar capability in any reasonable mission time. Barring new physics we are left with few realistic solutions. None of our current propulsion systems, including nuclear, are capable of the relativistic speeds needed for exploring the many nearby stellar systems and exo-planets. However recent advances in photonics and directed energy systems now allow us to realize what was only a decade ago, simply science fiction, namely the ability to seriously conceive of and plan for relativistic flight. From fully-functional gram-level wafer-scale spacecraft capable of speeds greater than c/4 that could reach the nearest star in 20 years to spacecraft for large missions capable of supporting human life with masses more than 105 kg (100 tons) for rapid interplanetary transit that could reach speeds of greater than 1000 km/s can be realized. With this technology spacecraft can be propelled to speeds currently unimaginable. Photonics, like electronics, and unlike chemical propulsion is an exponential technology with a current double time of about 20 months. This is the key. The cost of such a system is amortized over the essentially unlimited number of launches. In addition, the same photon driver can be used for many other purposes including beamed energy to power high Isp ion engines, remote asteroid composition analysis and planetary defense. This would be a profound change in human capability with enormous implications. Known as Starlight we are now in a NASA Phase II study. The FY 2017 congressional appropriations request directs NASA to study the feasibility of an interstellar mission to coincide with the 100th

  3. TerraSAR-X mission

    Science.gov (United States)

    Werninghaus, Rolf

    2004-01-01

    The TerraSAR-X is a German national SAR- satellite system for scientific and commercial applications. It is the continuation of the scientifically and technologically successful radar missions X-SAR (1994) and SRTM (2000) and will bring the national technology developments DESA and TOPAS into operational use. The space segment of TerraSAR-X is an advanced high-resolution X-Band radar satellite. The system design is based on a sound market analysis performed by Infoterra. The TerraSAR-X features an advanced high-resolution X-Band Synthetic Aperture Radar based on the active phased array technology which allows the operation in Spotlight-, Stripmap- and ScanSAR Mode with various polarizations. It combines the ability to acquire high resolution images for detailed analysis as well as wide swath images for overview applications. In addition, experimental modes like the Dual Receive Antenna Mode allow for full-polarimetric imaging as well as along track interferometry, i.e. moving target identification. The Ground Segment is optimized for flexible response to (scientific and commercial) User requests and fast image product turn-around times. The TerraSAR-X mission will serve two main goals. The first goal is to provide the strongly supportive scientific community with multi-mode X-Band SAR data. The broad spectrum of scientific application areas include Hydrology, Geology, Climatology, Oceanography, Environmental Monitoring and Disaster Monitoring as well as Cartography (DEM Generation) and Interferometry. The second goal is the establishment of a commercial EO-market in Europe which is driven by Infoterra. The commercial goal is the development of a sustainable EO-business so that the e.g. follow-on systems can be completely financed by industry from the profit. Due to its commercial potential, the TerraSAR-X project will be implemented based on a public-private partnership with the Astrium GmbH. This paper will describe first the mission objectives as well as the

  4. Space Mission : Y3K

    Science.gov (United States)

    2001-01-01

    ESA and the APME are hosting a contest for 10 - 15 year olds in nine European countries (Austria, Belgium, France, Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom). The contest is based on an interactive CD ROM, called Space Mission: Y3K, which explores space technology and shows some concrete uses of that technology in enhancing the quality of life on Earth. The CD ROM invites kids to join animated character Space Ranger Pete on an action-packed, colourful journey through space. Space Ranger Pete begins on Earth: the user navigates around a 'locker room' to learn about synthetic materials used in rocket boosters, heat shields, space suits and helmets, and how these materials have now become indispensable to everyday life. From Earth he flies into space and the user follows him from the control room in the spacecraft to a planet, satellites and finally to the International Space Station. Along the way, the user jots down clues that he or she discovers in this exploration, designing an imaginary space community and putting together a submission for the contest. The lucky winners will spend a weekend training as "junior astronauts" at the European Space Centre in Belgium (20-22 April 2001). They will be put through their astronaut paces, learning the art of space walking, running their own space mission, piloting a space capsule and re-entering the Earth's atmosphere. The competition features in various youth media channels across Europe. In the UK, popular BBC Saturday morning TV show, Live & Kicking, will be launching the competition and will invite viewers to submit their space community designs to win a weekend at ESC. In Germany, high circulation children's magazine Geolino will feature the competition in the January issue and on their internet site. And youth magazine ZoZitDat will feature the competition in the Netherlands throughout February. Space Mission: Y3K is part of an on-going partnership between the ESA's Technology Transfer

  5. The Comet Radar Explorer Mission

    Science.gov (United States)

    Asphaug, Erik; Belton, Mike; Bockelee-Morvan, Dominique; Chesley, Steve; Delbo, Marco; Farnham, Tony; Gim, Yonggyu; Grimm, Robert; Herique, Alain; Kofman, Wlodek; Oberst, Juergen; Orosei, Roberto; Piqueux, Sylvain; Plaut, Jeff; Robinson, Mark; Sava, Paul; Heggy, Essam; Kurth, William; Scheeres, Dan; Denevi, Brett; Turtle, Elizabeth; Weissman, Paul

    2014-11-01

    Missions to cometary nuclei have revealed major geological surprises: (1) Global scale layers - do these persist through to the interior? Are they a record of primary accretion? (2) Smooth regions - are they landslides originating on the surface? Are they cryovolcanic? (3) Pits - are they impact craters or sublimation pits, or rooted in the interior? Unambiguous answers to these and other questions can be obtained by high definition 3D radar reflection imaging (RRI) of internal structure. RRI can answer many of the great unknowns in planetary science: How do primitive bodies accrete? Are cometary nuclei mostly ice? What drives their spectacular activity and evolution? The Comet Radar Explorer (CORE) mission will image the detailed internal structure of the nucleus of 10P/Tempel 2. This ~16 x 8 x 7 km Jupiter Family Comet (JFC), or its parent body, originated in the outer planets region possibly millions of years before planet formation. CORE arrives post-perihelion and observes the comet’s waning activity from safe distance. Once the nucleus is largely dormant, the spacecraft enters a ~20-km dedicated Radar Mapping Orbit (RMO). The exacting design of the RRI experiment and the precise navigation of RMO will achieve a highly focused 3D radar reflection image of internal structure, to tens of meters resolution, and tomographic images of velocity and attenuation to hundreds of meters resolution, tied to the gravity model and shape. Visible imagers will produce maps of the surface morphology, albedo, color, texture, and photometric response, and images for navigation and shape determination. The cameras will also monitor the structure and dynamics of the coma, and its dusty jets, allowing their correlation in 3D with deep interior structures and surface features. Repeated global high-resolution thermal images will probe the near-surface layers heated by the Sun. Derived maps of thermal inertia will be correlated with the radar boundary response, and photometry and

  6. Bone Metabolism on ISS Missions

    Science.gov (United States)

    Smith, S. M.; Heer, M. A.; Shackelford, L. C.; Zwart, S. R.

    2014-01-01

    Spaceflight-induced bone loss is associated with increased bone resorption (1, 2), and either unchanged or decreased rates of bone formation. Resistive exercise had been proposed as a countermeasure, and data from bed rest supported this concept (3). An interim resistive exercise device (iRED) was flown for early ISS crews. Unfortunately, the iRED provided no greater bone protection than on missions where only aerobic and muscular endurance exercises were available (4, 5). In 2008, the Advanced Resistive Exercise Device (ARED), a more robust device with much greater resistance capability, (6, 7) was launched to the ISS. Astronauts who had access to ARED, coupled with adequate energy intake and vitamin D status, returned from ISS missions with bone mineral densities virtually unchanged from preflight (7). Bone biochemical markers showed that while the resistive exercise and adequate energy consumption did not mitigate the increased bone resorption, bone formation was increased (7, 8). The typical drop in circulating parathyroid hormone did not occur in ARED crewmembers. In 2014, an updated look at the densitometry data was published. This study confirmed the initial findings with a much larger set of data. In 42 astronauts (33 male, 9 female), the bone mineral density response to flight was the same for men and women (9), and those with access to the ARED did not have the typical decrease in bone mineral density that was observed in early ISS crewmembers with access to the iRED (Figure 1) (7). Biochemical markers of bone formation and resorption responded similarly in men and women. These data are encouraging, and represent the first in-flight evidence in the history of human space flight that diet and exercise can maintain bone mineral density on long-duration missions. However, the maintenance of bone mineral density through bone remodeling, that is, increases in both resorption and formation, may yield a bone with strength characteristics different from those

  7. Phoenix - the First Mars Scout Mission

    Science.gov (United States)

    Goldstein, Barry; Shotwell, Robert

    2008-01-01

    As the first of the new Mars Scouts missions, the Phoenix project was selected by NASA in August of 2003. Four years later, almost to the day, Phoenix was launched from Cape Canaveral Air Station and successfully injected into an interplanetary trajectory on its way to Mars. This paper will highlight some of the key changes since the 2006 IEEE paper of the same name, as well as activities, challenges and problems encountered on the way to the launch pad. Phoenix Follows the water responding directly to the recently published data from Dr. William Boynton, PI (and Phoenix co-I) of the Mars Odyssey Gamma Ray Spectrometer (GRS). GRS data indicate extremely large quantities of water ice (up to 50% by mass) within the upper 50 cm of the northern polar regolith. Phoenix will land within the north polar region at 68.2 N, 233.4 W identified by GRS to harbor near surface water ice and provide in-situ confirmation of this extraordinary find. Our mission will investigate water in all its phases, and will investigate the history of water as evidenced in the soil characteristics that will be carefully examined by the powerful suite of onboard instrumentation. Access to the critical subsurface region expected to contain this information is made possible by a third generation robotic arm capable of excavating the expected Martian regolith to a depth of 1m. Phoenix has four primary science objectives: 1) Determine the polar climate and weather, interaction with the surface, and composition of the lower atmosphere around 70 N for at least 90 sols focusing on water, ice, dust, noble gases, and CO2. Determine the atmospheric characteristics during descent through the atmosphere. 2) Characterize the geomorphology and active processes shaping the northern plains and the physical properties of the near surface regolith focusing on the role of water. 3) Determine the aqueous mineralogy and chemistry as well as the adsorbed gases and organic content of the regolith. Verify the Odyssey

  8. Work continues on Destiny, the U.S. Lab module, in the Space Station Processing Facility

    Science.gov (United States)

    1999-01-01

    In the Space Station Processing Facility (SSPF), work continues on the U.S. Lab module, Destiny, which is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the International Space Station. Destiny shares space in the SSPF with the Shuttle Radar Topography Mission (SRTM) and Leonardo, the Multipurpose Logistics Module (MPLM) built by the Agenzia Spaziale Italiana (ASI). The SRTM is targeted for launch on mission STS-99 in September 1999. Leonardo is scheduled to launch on mission STS- 102 in June 2000.

  9. Lifetime Prediction of IGBT Modules based on Linear Damage Accumulation

    DEFF Research Database (Denmark)

    Choi, Uimin; Blaabjerg, Frede; Ma, Ke

    2017-01-01

    In this paper, the lifetime prediction of power device modules based on the linear damage accumulation in conjunction with real mission profile assessment is studied. Four tests are performed under two superimposed power cycling conditions using an advanced power cycling test setup with 600 V, 30...

  10. Job Orders (Ordres de mission)

    CERN Multimedia

    Organisation & Procedures, FI Department, Tel. 73905

    2005-01-01

    Please note that individual job orders and continuous job orders (valid for one calendar year, i.e. from 1st January to 31st December) must henceforth be completed via EDH and approved by the Department Leader concerned (or the person appointed by him via EDHAdmin). Once approved, the form must be printed and kept for the duration of the mission by the driver to whom the job order is issued. You will find the icon for this document on the EDH Desktop, as well as on-line help on how to use it. In emergencies, paper copies of individual job orders (SCEM 54.50.20.168.5) may be issued outside normal working hours by the Fire Brigade (Meyrin Site, Building 65). Organisation & Procedures, FI Department, Tel. 73905 Relations with the Host States Service, Tel. 72848

  11. Cassini Mission Sequence Subsystem (MSS)

    Science.gov (United States)

    Alland, Robert

    2011-01-01

    This paper describes my work with the Cassini Mission Sequence Subsystem (MSS) team during the summer of 2011. It gives some background on the motivation for this project and describes the expected benefit to the Cassini program. It then introduces the two tasks that I worked on - an automatic system auditing tool and a series of corrections to the Cassini Sequence Generator (SEQ_GEN) - and the specific objectives these tasks were to accomplish. Next, it details the approach I took to meet these objectives and the results of this approach, followed by a discussion of how the outcome of the project compares with my initial expectations. The paper concludes with a summary of my experience working on this project, lists what the next steps are, and acknowledges the help of my Cassini colleagues.

  12. The heat capacity mapping mission

    Science.gov (United States)

    Short, N. M.

    1981-01-01

    The first in a series of low cost Atmospheric Explorer Satellites, the Heat Capacity Mapping Mission (HCMM) was designed to evaluate the utility of thermal inertial and other thermal and reflectance data for: (1) discriminating bedrock and unconsolidated regolith types; (2) mapping soil moisture; (3) measuring plant canopy temperatures; (4) examining thermal circulation in large bodies of water; and (5) monitoring urban heat islands. Final reports from the HCMM investigator's program are beginning to define the utility of day/the night thermal data. Under favorable circumstances, some major rock types can be identified, soil moisture in extensive agricultural and alluvial terrains can be detected and at least semiqualitatively assessed; and circulation of currents in large bodies of water can be followed by noting thermal patterns.

  13. JUICE space mission to Jupiter

    CERN Multimedia

    CERN. Geneva

    2018-01-01

    JUICE - JUpiter ICy moons Explorer - is the first large-class mission in ESA's Cosmic Vision 2015-2025 programme. Planned for launch in 2022 and arrival at Jupiter in 2029, it will spend at least three years making detailed observations of the giant gaseous planet Jupiter and three of its largest moons, Ganymede, Callisto and Europa. JUICE will perform detailed investigations of Jupiter and its system in all their inter-relations and complexity with particular emphasis on Ganymede as a planetary body and potential habitat. Investigations of Europa and Callisto would complete a comparative picture of the Galilean moons. Jupiter is the archetype for the giant planets of the Solar System and for the numerous giant planets now known to orbit other stars. Moreover, Jupiter's diverse Galilean satellites - three of which are believed to harbour internal oceans - are central to understanding the habitability of icy worlds. JUICE spacecraft will carry the most powerful remote sensing, geophysical, and in situ paylo...

  14. Hummingbird Comet Nucleus Analysis Mission

    Science.gov (United States)

    Kojiro, Daniel; Carle, Glenn C.; Lasher, Larry E.

    2000-01-01

    Hummingbird is a highly focused scientific mission, proposed to NASA s Discovery Program, designed to address the highest priority questions in cometary science-that of the chemical composition of the cometary nucleus. After rendezvous with the comet, Hummingbird would first methodically image and map the comet, then collect and analyze dust, ice and gases from the cometary atmosphere to enrich characterization of the comet and support landing site selection. Then, like its namesake, Hummingbird would carefully descend to a pre-selected surface site obtaining a high-resolution image, gather a surface material sample, acquire surface temperature and then immediately return to orbit for detailed chemical and elemental analyses followed by a high resolution post-sampling image of the site. Hummingbird s analytical laboratory contains instrumentation for a comprehensive molecular and elemental analysis of the cometary nucleus as well as an innovative surface sample acquisition device.

  15. Astronaut Vance Brand practices operating Docking Module hatch for ASTP

    Science.gov (United States)

    1975-01-01

    Astronaut Vance D. Brand, command module pilot of the American Apollo Soyuz Test Project (ASTP) prime crew, practices operating a Docking Module hatch during ASTP pre-flight training at JSC. The Docking Module is designed to link the Apollo and Soyuz spacecraft during their docking in Earth orbit mission. Gary L. Doerre of JSC's Crew Training and Procedures Division is working with Brand. Doerre is wearing a face mask to help prevent possible exposure to Brand of disease prior to the ASTP launch.

  16. THE JEM-EUSO MISSION

    Directory of Open Access Journals (Sweden)

    Mario Bertaina

    2013-12-01

    Full Text Available The JEM-EUSO mission explores the origin of the extreme energy cosmic rays (EECRs above 50EeV and explores the limits of the fundamental physics, through the observations of their arrival directions and energies. It is designed to open a new particle astronomy channel. This superwide-field (60 degrees telescope with a diameter of about 2.5m looks down from space onto the night sky to detect near UV photons (330 ÷ 400nm, both fluorescent and Cherenkov photons emitted from the giant air showers produced by EECRs. The arrival direction map with more than five hundred events will tell us the origin of the EECRs and allow us to identify the nearest EECR sources with known astronomical objects. It will allow them to be examined in other astronomical channels. This is likely to lead to an  nderstanding of the acceleration mechanisms perhaps producing discoveries in astrophysics and/or fundamental physics. The comparison of the energy spectra among the spatially resolved individual sources will help to clarify the acceleration/emission mechanism, and also finally confirm the Greisen–Zatsepin–Kuz’min process for the validation of Lorentz invariance up to γ ~ 1011. Neutral components (neutrinos and gamma rays can also be detected as well, if their fluxes are high enough. The JEM-EUSO mission is planned to be launched by a H2B rocket about 2017 and transferred to ISS by H2 Transfer Vehicle (HTV. It will be attached to the Exposed Facility external experiment platform of “KIBO”.

  17. Space Synthetic Biology Project

    Science.gov (United States)

    Howard, David; Roman, Monsi; Mansell, James (Matt)

    2015-01-01

    Synthetic biology is an effort to make genetic engineering more useful by standardizing sections of genetic code. By standardizing genetic components, biological engineering will become much more similar to traditional fields of engineering, in which well-defined components and subsystems are readily available in markets. Specifications of the behavior of those components and subsystems can be used to model a system which incorporates them. Then, the behavior of the novel system can be simulated and optimized. Finally, the components and subsystems can be purchased and assembled to create the optimized system, which most often will exhibit behavior similar to that indicated by the model. The Space Synthetic Biology project began in 2012 as a multi-Center effort. The purpose of this project was to harness Synthetic Biology principals to enable NASA's missions. A central target for application was to Environmental Control & Life Support (ECLS). Engineers from NASA Marshall Space Flight Center's (MSFC's) ECLS Systems Development Branch (ES62) were brought into the project to contribute expertise in operational ECLS systems. Project lead scientists chose to pursue the development of bioelectrochemical technologies to spacecraft life support. Therefore, the ECLS element of the project became essentially an effort to develop a bioelectrochemical ECLS subsystem. Bioelectrochemical systems exploit the ability of many microorganisms to drive their metabolisms by direct or indirect utilization of electrical potential gradients. Whereas many microorganisms are capable of deriving the energy required for the processes of interest (such as carbon dioxide (CO2) fixation) from sunlight, it is believed that subsystems utilizing electrotrophs will exhibit smaller mass, volume, and power requirements than those that derive their energy from sunlight. In the first 2 years of the project, MSFC personnel conducted modeling, simulation, and conceptual design efforts to assist the

  18. Biological effects

    International Nuclear Information System (INIS)

    Trott, K.R.

    1973-01-01

    Following an introduction into the field of cellular radiation effect considering the most important experimental results, the biological significance of the colony formation ability is brought out. The inactivation concept of stem cells does not only prove to be good, according to the present results, in the interpretation of the pathogenesis of acute radiation effects on moult tissue, it also enables chronicle radiation injuries to be interpreted through changes in the fibrous part of the organs. Radiation therapy of tumours can also be explained to a large extent by the radiation effect on the unlimited reproductiveness of tumour cells. The more or less similar dose effect curves for healthy and tumour tissue in practice lead to intermittent irradiation. The dependence of the intermittent doses and intervals on factors such as Elkind recovery, synchronisation, redistribution, reoxygenation, repopulation and regeneration are reviewed. (ORU/LH) [de

  19. Agile: From Software to Mission System

    Science.gov (United States)

    Trimble, Jay; Shirley, Mark H.; Hobart, Sarah Groves

    2016-01-01

    The Resource Prospector (RP) is an in-situ resource utilization (ISRU) technology demonstration mission, designed to search for volatiles at the Lunar South Pole. This is NASA's first near real time tele-operated rover on the Moon. The primary objective is to search for volatiles at one of the Lunar Poles. The combination of short mission duration, a solar powered rover, and the requirement to explore shadowed regions makes for an operationally challenging mission. To maximize efficiency and flexibility in Mission System design and thus to improve the performance and reliability of the resulting Mission System, we are tailoring Agile principles that we have used effectively in ground data system software development and applying those principles to the design of elements of the mission operations system.

  20. Missions and planning for nuclear space power

    International Nuclear Information System (INIS)

    Buden, D.

    1979-01-01

    Requirements for electrical and propulsion power for space are expected to increase dramatically in the 1980s. Nuclear power is probably the only source for some deep space missions and a major competitor for many orbital missions, especially those at geosynchronous orbit. Because of the potential requirements, a technology program on reactor components has been initiated by the Department of Energy. The missions that are foreseen, the current reactor concept, and the technology program plan are described

  1. The Voyager mission through the Jupiter encounters

    OpenAIRE

    Stone, E. C.

    1981-01-01

    The Voyager mission is a major element in NASA's program of exploration of the outer solar system. Objectives of the Voyager mission include comparative studies of the Jovian and Saturnian planetary systems and exploratory studies of the interplanetary medium at increasing distances from the sun. With the successful Saturn encounter in November 1980, the objectives of the mission have been extended to include an exploration of Uranus and interplanetary studies to beyond 20 astronomical units....

  2. Agile: From Software to Mission Systems

    Science.gov (United States)

    Trimble, Jay; Shirley, Mark; Hobart, Sarah

    2017-01-01

    To maximize efficiency and flexibility in Mission Operations System (MOS) design, we are evolving principles from agile and lean methods for software, to the complete mission system. This allows for reduced operational risk at reduced cost, and achieves a more effective design through early integration of operations into mission system engineering and flight system design. The core principles are assessment of capability through demonstration, risk reduction through targeted experiments, early test and deployment, and maturation of processes and tools through use.

  3. [Biological rhythms for anaesthesia and intensive care].

    Science.gov (United States)

    Dispersyn, G; Chassard, D; Pain, L

    2010-06-01

    Knowledge of biological rhythms has led to better understanding of the time-of-day dependent effects of anaesthetic drugs. These chronopharmacological effects are currently explained by the biological rhythms modulating the pharmacokinetic, toxic and pharmacodynamic parameters of these substances. Such effect has been described for general anesthetics, local anaesthetics, analgesics as well as for antibiotics. But recent data also highlight that general anaesthetics, probably part of their brain effects, also alter the regulation of biological rhythms, including the sleep-wake or the endogenous circadian temperature rhythms. This desynchronization of biological rhythms can led to disturbance of the circadian secretion of many substances, including hormones. Finally, biological rhythms have been also described with regard to physiology of pain and cardiovascular physiopathology. The concept of biological rhythm should be present in mind not only for the clinical management of patients but also for setting studies in the field of anaesthesia, pain and intensive care. 2010. Published by Elsevier SAS.

  4. Sustainable, Reliable Mission-Systems Architecture

    Science.gov (United States)

    O'Neil, Graham; Orr, James K.; Watson, Steve

    2007-01-01

    A mission-systems architecture, based on a highly modular infrastructure utilizing: open-standards hardware and software interfaces as the enabling technology is essential for affordable and sustainable space exploration programs. This mission-systems architecture requires (a) robust communication between heterogeneous system, (b) high reliability, (c) minimal mission-to-mission reconfiguration, (d) affordable development, system integration, and verification of systems, and (e) minimal sustaining engineering. This paper proposes such an architecture. Lessons learned from the Space Shuttle program and Earthbound complex engineered system are applied to define the model. Technology projections reaching out 5 years are mde to refine model details.

  5. Flexible UAV Mission Management Using Emerging Technologies

    National Research Council Canada - National Science Library

    Desimone, Roberto; Lee, Richard

    2002-01-01

    This paper discusses recent results and proposed work in the application of emerging artificial intelligence technologies for flexible mission management, especially for unmanned (combat) airborne vehicles...

  6. NASA Laboratory Analysis for Manned Exploration Missions

    Science.gov (United States)

    Krihak, Michael K.; Shaw, Tianna E.

    2014-01-01

    The Exploration Laboratory Analysis (ELA) project supports the Exploration Medical Capability Element under the NASA Human Research Program. ELA instrumentation is identified as an essential capability for future exploration missions to diagnose and treat evidence-based medical conditions. However, mission architecture limits the medical equipment, consumables, and procedures that will be available to treat medical conditions during human exploration missions. Allocated resources such as mass, power, volume, and crew time must be used efficiently to optimize the delivery of in-flight medical care. Although commercial instruments can provide the blood and urine based measurements required for exploration missions, these commercial-off-the-shelf devices are prohibitive for deployment in the space environment. The objective of the ELA project is to close the technology gap of current minimally invasive laboratory capabilities and analytical measurements in a manner that the mission architecture constraints impose on exploration missions. Besides micro gravity and radiation tolerances, other principal issues that generally fail to meet NASA requirements include excessive mass, volume, power and consumables, and nominal reagent shelf-life. Though manned exploration missions will not occur for nearly a decade, NASA has already taken strides towards meeting the development of ELA medical diagnostics by developing mission requirements and concepts of operations that are coupled with strategic investments and partnerships towards meeting these challenges. This paper focuses on the remote environment, its challenges, biomedical diagnostics requirements and candidate technologies that may lead to successful blood-urine chemistry and biomolecular measurements in future space exploration missions.

  7. Lessons learned from IAEA fire safety missions

    International Nuclear Information System (INIS)

    Lee, S.P.

    1998-01-01

    The IAEA has conducted expert missions to evaluate fire safety at the following nuclear power plants: the Zaporozhe plant in the Ukraine, the Borselle plant in the Netherlands, the Medzamor plant in Armenia, the Karachi plant in Pakistan, the Temelin plant in the Czech Republic, and the Laguna Verde plant in Mexico. The scope of these missions varied in subject and depth. The teams sent from the IAEA consisted of external fire experts and IAEA staff. All the missions were of great use to the host countries. The participating experts also benefited significantly. A summary of the missions and their findings is given. (author)

  8. Possible LISA Technology Applications for Other Missions

    Science.gov (United States)

    Livas, Jeffrey

    2018-01-01

    The Laser Interferometer Space Antenna (LISA) has been selected as the third large class mission launch opportunity of the Cosmic Visions Program by the European Space Agency (ESA). LISA science will explore a rich spectrum of astrophysical gravitational-wave sources expected at frequencies between 0.0001 and 0.1 Hz and complement the work of other observatories and missions, both space and ground-based, electromagnetic and non-electromagnetic. Similarly, LISA technology may find applications for other missions. This paper will describe the capabilities of some of the key technologies and discuss possible contributions to other missions.

  9. Autolanding for Sample Return Missions, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Future NASA and commercial missions will increasingly target destinations with challenging topography and limited communication including unmapped asteroids, comets,...

  10. Rapid Automated Mission Planning System, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation is an automated UAS mission planning system that will rapidly identify emergency (contingency) landing sites, manage contingency routing, and...

  11. Space Mission Human Reliability Analysis (HRA) Project

    Science.gov (United States)

    Boyer, Roger

    2014-01-01

    The purpose of the Space Mission Human Reliability Analysis (HRA) Project is to extend current ground-based HRA risk prediction techniques to a long-duration, space-based tool. Ground-based HRA methodology has been shown to be a reasonable tool for short-duration space missions, such as Space Shuttle and lunar fly-bys. However, longer-duration deep-space missions, such as asteroid and Mars missions, will require the crew to be in space for as long as 400 to 900 day missions with periods of extended autonomy and self-sufficiency. Current indications show higher risk due to fatigue, physiological effects due to extended low gravity environments, and others, may impact HRA predictions. For this project, Safety & Mission Assurance (S&MA) will work with Human Health & Performance (HH&P) to establish what is currently used to assess human reliabiilty for human space programs, identify human performance factors that may be sensitive to long duration space flight, collect available historical data, and update current tools to account for performance shaping factors believed to be important to such missions. This effort will also contribute data to the Human Performance Data Repository and influence the Space Human Factors Engineering research risks and gaps (part of the HRP Program). An accurate risk predictor mitigates Loss of Crew (LOC) and Loss of Mission (LOM).The end result will be an updated HRA model that can effectively predict risk on long-duration missions.

  12. [The mission of Princeton Plasma Physics Laboratory

    International Nuclear Information System (INIS)

    1993-01-01

    This report discusses the following about Princeton Plasma Physics Laboratory: its mission; requirements and guidance documents for the QA program; architecture; assessment organization; and specific management issues

  13. Creating biological nanomaterials using synthetic biology.

    Science.gov (United States)

    Rice, MaryJoe K; Ruder, Warren C

    2014-02-01

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems.

  14. Creating biological nanomaterials using synthetic biology

    International Nuclear Information System (INIS)

    Rice, MaryJoe K; Ruder, Warren C

    2014-01-01

    Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields such as biomedicine and biochemical engineering. Additionally, biological networks can also be critical to the production of naturally occurring biological nanomaterials, and as a result, synthetic biology holds tremendous potential in creating new materials. This review introduces the field of synthetic biology, discusses how biological systems naturally produce materials, and then presents examples and strategies for incorporating synthetic biology approaches in the development of new materials. In particular, strategies for using synthetic biology to produce both organic and inorganic nanomaterials are discussed. Ultimately, synthetic biology holds the potential to dramatically impact biological materials science with significant potential applications in medical systems. (review)

  15. Cubesat Application for Planetary Entry (CAPE) Missions: Micro-Reentry Capsule (MIRCA)

    Science.gov (United States)

    Esper, Jaime

    2014-01-01

    The Cubesat Application for Planetary Entry Missions (CAPE) concept describes a high-performing Cubesat system which includes a propulsion module and miniaturized technologies capable of surviving atmospheric entry heating, while reliably transmitting scientific and engineering data. The Micro Return Capsule (MIRCA) is CAPEs first planetary entry probe flight prototype. Within this context, this paper briefly describes CAPEs configuration and typical operational scenario, and summarizes ongoing work on the design and basic aerodynamic characteristics of the prototype MIRCA vehicle. CAPE not only opens the door to new planetary mission capabilities, it also offers relatively low-cost opportunities especially suitable to university participation.

  16. Redox Modulations, Antioxidants, and Neuropsychiatric Disorders

    Science.gov (United States)

    Fraunberger, Erik A.; Laliberté, Victoria L. M.; Duong, Angela; Andreazza, Ana C.

    2016-01-01

    Although antioxidants, redox modulations, and neuropsychiatric disorders have been widely studied for many years, the field would benefit from an integrative and corroborative review. Our primary objective is to delineate the biological significance of compounds that modulate our redox status (i.e., reactive species and antioxidants) as well as outline their current role in brain health and the impact of redox modulations on the severity of illnesses. Therefore, this review will not enter into the debate regarding the perceived medical legitimacy of antioxidants but rather seek to clarify their abilities and limitations. With this in mind, antioxidants may be interpreted as natural products with significant pharmacological actions in the body. A renewed understanding of these often overlooked compounds will allow us to critically appraise the current literature and provide an informed, novel perspective on an important healthcare issue. In this review, we will introduce the complex topics of redox modulations and their role in the development of select neuropsychiatric disorders. PMID:26640614

  17. SLS launched missions concept studies for LUVOIR mission

    Science.gov (United States)

    Stahl, H. Philip; Hopkins, Randall C.

    2015-09-01

    NASA's "Enduring Quests Daring Visions" report calls for an 8- to 16-m Large UV-Optical-IR (LUVOIR) Surveyor mission to enable ultra-high-contrast spectroscopy and coronagraphy. AURA's "From Cosmic Birth to Living Earth" report calls for a 12-m class High-Definition Space Telescope to pursue transformational scientific discoveries. The multi-center ATLAST Team is working to meet these needs. The MSFC Team is examining potential concepts that leverage the advantages of the SLS (Space Launch System). A key challenge is how to affordably get a large telescope into space. The JWST design was severely constrained by the mass and volume capacities of its launch vehicle. This problem is solved by using an SLS Block II-B rocket with its 10-m diameter x 30-m tall fairing and estimated 45 mt payload to SE-L2. Previously, two development study cycles produced a detailed concept called ATLAST-8. Using ATLAST-8 as a point of departure, this paper reports on a new ATLAST-12 concept. ATLAST-12 is a 12-m class segmented aperture LUVOIR with an 8-m class center segment. Thus, ATLAST-8 is now a de-scope option.

  18. SLS Launched Missions Concept Studies for LUVOIR Mission

    Science.gov (United States)

    Stahl, H. Philip; Hopkins, Randall C.

    2015-01-01

    NASA's "Enduring Quests Daring Visions" report calls for an 8- to 16-meter Large UV-Optical-IR (LUVOIR) Surveyor mission to enable ultra-high-contrast spectroscopy and coronagraphy. AURA's "From Cosmic Birth to Living Earth" report calls for a 12-meter class High-Definition Space Telescope to pursue transformational scientific discoveries. The multi-center ATLAST Team is working to meet these needs. The MSFC Team is examining potential concepts that leverage the advantages of the SLS (Space Launch System). A key challenge is how to affordably get a large telescope into space. The JWST design was severely constrained by the mass and volume capacities of its launch vehicle. This problem is solved by using an SLS Block II-B rocket with its 10-m diameter x 30-m tall fairing and 45 mt payload to SE-L2. Previously, two development study cycles produced a detailed concept called ATLAST-8. Using ATLAST-8 as a point of departure, this paper reports on a new ATLAST-12 concept. ATLAST-12 is a 12-meter class segmented aperture LUVOIR with an 8-m class center segment. Thus, ATLAST-8 is now a de-scope option.

  19. An Alternative Water Processor for Long Duration Space Missions

    Science.gov (United States)

    Barta, Daniel J.; Pickering, Karen D.; Meyer, Caitlin; Pennsinger, Stuart; Vega, Leticia; Flynn, Michael; Jackson, Andrew; Wheeler, Raymond

    2014-01-01

    A new wastewater recovery system has been developed that combines novel biological and physicochemical components for recycling wastewater on long duration human space missions. Functionally, this Alternative Water Processor (AWP) would replace the Urine Processing Assembly on the International Space Station and reduce or eliminate the need for the multi-filtration beds of the Water Processing Assembly (WPA). At its center are two unique game changing technologies: 1) a biological water processor (BWP) to mineralize organic forms of carbon and nitrogen and 2) an advanced membrane processor (Forward Osmosis Secondary Treatment) for removal of solids and inorganic ions. The AWP is designed for recycling larger quantities of wastewater from multiple sources expected during future exploration missions, including urine, hygiene (hand wash, shower, oral and shave) and laundry. The BWP utilizes a single-stage membrane-aerated biological reactor for simultaneous nitrification and denitrification. The Forward Osmosis Secondary Treatment (FOST) system uses a combination of forward osmosis (FO) and reverse osmosis (RO), is resistant to biofouling and can easily tolerate wastewaters high in non-volatile organics and solids associated with shower and/or hand washing. The BWP has been operated continuously for over 300 days. After startup, the mature biological system averaged 85% organic carbon removal and 44% nitrogen removal, close to stoichiometric maximum based on available carbon. To date, the FOST has averaged 93% water recovery, with a maximum of 98%. If the wastewater is slighty acidified, ammonia rejection is optimal. This paper will provide a description of the technology and summarize results from ground-based testing using real wastewater

  20. An Alternative Water Processor for Long Duration Space Missions

    Science.gov (United States)

    Barta, Daniel J.; Wheeler, Raymond; Jackson, William; Pickering, Karen; Meyer, Caitlin; Pensinger, Stuart; Vega, Leticia; Flynn, Michael

    A new wastewater recovery system has been developed that combines novel biological and physicochemical components for recycling wastewater on long duration space missions. Functionally, this Alternative Water Processor (AWP) would replace the Urine Processing Assembly on the International Space Station and reduce or eliminate the need for the multi-filtration beds of the Water Processing Assembly (WPA). At its center are two unique game changing technologies: 1) a biological water processor (BWP) to mineralize organic forms of carbon and nitrogen and 2) an advanced membrane processor (Forward Osmosis Secondary Treatment) for removal of solids and inorganic ions. The AWP is designed for recycling larger quantities of wastewater from multiple sources expected during future exploration missions, including urine, hygiene (hand wash, shower, oral and shave) and laundry. The BWP utilizes a single-stage membrane-aerated biological reactor for simultaneous nitrification and denitrification. The Forward Osmosis Secondary Treatment (FOST) system uses a combination of forward osmosis (FO) and reverse osmosis (RO), is resistant to biofouling and can easily tolerate wastewaters high in non-volatile organics and solids associated with shower and/or hand washing. The BWP has been operated continuously for over 300 days. After startup, the mature biological system averaged 85% organic carbon removal and 44% nitrogen removal, close to maximum based on available carbon. To date, the FOST has averaged 93% water recovery, with a maximum of 98%. If the wastewater is slighty acidified, ammonia rejection is optimal. This paper will provide a description of the technology and summarize results from ground-based testing using real wastewater.

  1. Synergistic Synthetic Biology: Units in Concert

    Science.gov (United States)

    Trosset, Jean-Yves; Carbonell, Pablo

    2013-01-01

    Synthetic biology aims at translating the methods and strategies from engineering into biology in order to streamline the design and construction of biological devices through standardized parts. Modular synthetic biology devices are designed by means of an adequate elimination of cross-talk that makes circuits orthogonal and specific. To that end, synthetic constructs need to be adequately optimized through in silico modeling by choosing the right complement of genetic parts and by experimental tuning through directed evolution and craftsmanship. In this review, we consider an additional and complementary tool available to the synthetic biologist for innovative design and successful construction of desired circuit functionalities: biological synergies. Synergy is a prevalent emergent property in biological systems that arises from the concerted action of multiple factors producing an amplification or cancelation effect compared with individual actions alone. Synergies appear in domains as diverse as those involved in chemical and protein activity, polypharmacology, and metabolic pathway complementarity. In conventional synthetic biology designs, synergistic cross-talk between parts and modules is generally attenuated in order to verify their orthogonality. Synergistic interactions, however, can induce emergent behavior that might prove useful for synthetic biology applications, like in functional circuit design, multi-drug treatment, or in sensing and delivery devices. Synergistic design principles are therefore complementary to those coming from orthogonal design and may provide added value to synthetic biology applications. The appropriate modeling, characterization, and design of synergies between biological parts and units will allow the discovery of yet unforeseeable, novel synthetic biology applications. PMID:25022769

  2. Synergistic Synthetic Biology: Units in Concert

    International Nuclear Information System (INIS)

    Trosset, Jean-Yves; Carbonell, Pablo

    2013-01-01

    Synthetic biology aims at translating the methods and strategies from engineering into biology in order to streamline the design and construction of biological devices through standardized parts. Modular synthetic biology devices are designed by means of an adequate elimination of cross-talk that makes circuits orthogonal and specific. To that end, synthetic constructs need to be adequately optimized through in silico modeling by choosing the right complement of genetic parts and by experimental tuning through directed evolution and craftsmanship. In this review, we consider an additional and complementary tool available to the synthetic biologist for innovative design and successful construction of desired circuit functionalities: biological synergies. Synergy is a prevalent emergent property in biological systems that arises from the concerted action of multiple factors producing an amplification or cancelation effect compared with individual actions alone. Synergies appear in domains as diverse as those involved in chemical and protein activity, polypharmacology, and metabolic pathway complementarity. In conventional synthetic biology designs, synergistic cross-talk between parts and modules is generally attenuated in order to verify their orthogonality. Synergistic interactions, however, can induce emergent behavior that might prove useful for synthetic biology applications, like in functional circuit design, multi-drug treatment, or in sensing and delivery devices. Synergistic design principles are therefore complementary to those coming from orthogonal design and may provide added value to synthetic biology applications. The appropriate modeling, characterization, and design of synergies between biological parts and units will allow the discovery of yet unforeseeable, novel synthetic biology applications.

  3. Reassessment of planetary protection requirements for Venus missions

    Science.gov (United States)

    Szostak, J.; Riemer, R.; Smith, D.; Rummel, J.

    In 2005 the US Space Studies Board SSB was asked by NASA to reexamine the planetary protection requirements for spacecraft missions to Venus In particular the SSB was tasked to 1 Assess the surface and atmospheric environments of Venus with respect to their ability to support the survival and growth of Earth-origin microbial contamination by future spacecraft missions and 2 Provide recommendations related to planetary protection issues associated with the return to Earth of samples from Venus The task group established by the SSB to address these issues assessed the known aspects of the present-day environment of Venus and the ability of Earth organisms to survive in the physical and chemical conditions found on the planet s surface or in the clouds in the planet s atmosphere As a result of its deliberations the task group found compelling evidence against there being significant dangers of forward or reverse biological contamination as a result of contact between a spacecraft and the surface of Venus or the clouds in the atmosphere of Venus regardless of the current unknowns The task group did however conclude that Venus is a body of interest relative to the process of chemical evolution and the origin of life As a result the task group endorses NASA s current policy of subjecting missions to Venus to the requirements imposed by planetary protection Category II rather than the less restrictive Category I recommended by COSPAR

  4. The Neurolab mission and biomedical engineering: a partnership for the future

    Science.gov (United States)

    Liskowsky, D. R.; Frey, M. A.; Sulzman, F. M.; White, R. J.; Likowsky, D. R.

    1996-01-01

    Over the last five years, with the advent of flights of U.S. Shuttle/Spacelab missions dedicated entirely to life sciences research, the opportunities for conducting serious studies that use a fully outfitted space laboratory to better understand basic biological processes have increased. The last of this series of Shuttle/Spacelab missions, currently scheduled for 1998, is dedicated entirely to neuroscience and behavioral research. The mission, named Neurolab, includes a broad range of experiments that build on previous research efforts, as well as studies related to less mature areas of space neuroscience. The Neurolab mission provides the global scientific community with the opportunity to use the space environment for investigations that exploit microgravity to increase our understanding of basic processes in neuroscience. The results from this premier mission should lead to a significant advancement in the field as a whole and to the opening of new lines of investigation for future research. Experiments under development for this mission will utilize human subjects as well as a variety of other species. The capacity to carry out detailed experiments on both human and animal subjects in space allows a diverse complement of studies that investigate functional changes and their underlying molecular, cellular, and physiological mechanisms. In order to conduct these experiments, a wide array of biomedical instrumentation will be used, including some instruments and devices being developed especially for the mission.

  5. PENGEMBANGAN BAHAN AJAR BIOLOGI SEL PADA PROGRAM STUDI PENDIDIKAN BIOLOGI UIN ALAUDDIN MAKASSAR

    OpenAIRE

    Muriati, St

    2015-01-01

    Learning in UIN Alauddin is still limited knowledge to students, while, one mission to improve the quality of educators Biology in terms of belief, moral and scientific attitudes have not been implemented. This is caused by a lack of learning resources that connects Biology Science and its relation to scientific Qur'an. Cell Biology as subjects that reveal about the phenomenon of the smallest unit of life, it can be studied with scientific Qur'an. Therefore, it is necessary to develop teachin...

  6. Satellite Ocean Biology: Past, Present, Future

    Science.gov (United States)

    McClain, Charles R.

    2012-01-01

    Since 1978 when the first satellite ocean color proof-of-concept sensor, the Nimbus-7 Coastal Zone Color Scanner, was launched, much progress has been made in refining the basic measurement concept and expanding the research applications of global satellite time series of biological and optical properties such as chlorophyll-a concentrations. The seminar will review the fundamentals of satellite ocean color measurements (sensor design considerations, on-orbit calibration, atmospheric corrections, and bio-optical algorithms), scientific results from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) and Moderate resolution Imaging Spectroradiometer (MODIS) missions, and the goals of future NASA missions such as PACE, the Aerosol, Cloud, Ecology (ACE), and Geostationary Coastal and Air Pollution Events (GeoCAPE) missions.

  7. Electroabsorption optical modulator

    Science.gov (United States)

    Skogen, Erik J.

    2017-11-21

    An electroabsorption modulator incorporates waveguiding regions along the length of the modulator that include quantum wells where at least two of the regions have quantum wells with different bandgaps. In one embodiment of the invention, the regions are arranged such that the quantum wells have bandgaps with decreasing bandgap energy along the length of the modulator from the modulator's input to its output. The bandgap energy of the quantum wells may be decreased in discrete steps or continuously. Advantageously, such an arrangement better distributes the optical absorption as well as the carrier density along the length of the modulator. Further advantageously, the modulator may handle increased optical power as compared with prior art modulators of similar dimensions, which allows for improved link gain when the optical modulator is used in an analog optical communication link.

  8. Electroabsorption optical modulator

    Energy Technology Data Exchange (ETDEWEB)

    Skogen, Erik J.

    2017-11-21

    An electroabsorption modulator incorporates waveguiding regions along the length of the modulator that include quantum wells where at least two of the regions have quantum wells with different bandgaps. In one embodiment of the invention, the regions are arranged such that the quantum wells have bandgaps with decreasing bandgap energy along the length of the modulator from the modulator's input to its output. The bandgap energy of the quantum wells may be decreased in discrete steps or continuously. Advantageously, such an arrangement better distributes the optical absorption as well as the carrier density along the length of the modulator. Further advantageously, the modulator may handle increased optical power as compared with prior art modulators of similar dimensions, which allows for improved link gain when the optical modulator is used in an analog optical communication link.

  9. CDC 7600 module slice

    CERN Multimedia

    Each module contained 8 circuit cards for a total of about 300-500 uncovered transistors packaged with face plates so the Freon plates wouldn't touch the circuits. (cooling plates that surrounded each module).

  10. Exploration Augmentation Module Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The Exploration Augmentation Module (EAM) project goal is to design and deliver a flight module that is to be deployed to Earth-Lunar Distant Retrograde Orbit (DRO)....

  11. Reduced Multiplication Modules

    Indian Academy of Sciences (India)

    for some ideal of . As defined for a commutative ring , an -module is said to be reduced if the intersection of prime submodules of is zero. The prime spectrum and minimal prime submodules of the reduced module are studied.

  12. Reduced multiplication modules

    Indian Academy of Sciences (India)

    for some ideal of . As defined for a commutative ring , an -module is said to be reduced if the intersection of prime submodules of is zero. The prime spectrum and minimal prime submodules of the reduced module are studied.

  13. Prospective Ukrainian lunar orbiter mission

    Science.gov (United States)

    Shkuratov, Y.; Litvinenko, L.; Shulga, V.; Yatskiv, Y.; Kislyuk, V.

    Ukraine has launch vehicles that are able to deliver about 300 kg to the lunar orbit. Future Ukrainian lunar program may propose a polar orbiter. This orbiter should fill principal information gaps in our knowledge about the Moon after Clementine and Lunar Prospector missions and the future missions, like Smart-1, Lunar-A, and Selene. We consider that this can be provided by radar studies of the Moon with supporting optical polarimetric observations from lunar polar orbit. These experiments allow one to better understand global structure of the lunar surface in a wide range of scales, from microns to kilometers. We propose three instruments for the prospective lunar orbiter. They are: a synthetic aperture imaging radar (SAR), ground-penetrating radar (GPR), and imaging polarimeter (IP). The main purpose of SAR is to study with high resolution (50 m) the permanently shadowed sites in the lunar polar regions. These sites are cold traps for volatiles, and have a potential of resource utilization. Possible presence of water ice in the regolith in the sites makes them interesting for permanent manned bases on the Moon. Radar imaging and mapping of other interesting regions could be also planned. Multi-frequencies multi-polarization soun d ing of the lunar surface with GPR can provide information about internal structure of the lunar surface from meters to several hundred meters deep. GPR can be used for measuring the megaregolith layer properties, detection of cryptomaria, and studies of internal structure of the largest craters. IP will be a CCD camera with an additional suite of polarizers. Modest spatial resolution (100 m) should provide a total coverage or a large portion of the lunar surface in oblique viewing basically at large phase angles. Polarization degree at large (>90°) phase angles bears information about characteristic size of the regolith particles. Additional radiophysical experiments are considered with the use of the SAR system, e.g., bistatic radar

  14. The LUVOIR Decadal Mission Concept

    Science.gov (United States)

    Arney, G. N.; Crooke, J.; Domagal-Goldman, S. D.; Fischer, D.; Peterson, B.; Schmidt, B. E.; Stdt, T. L. T.

    2017-12-01

    The Large UV-Optical-Infrared (LUVOIR) Surveyor is one of four mission concepts being studied by NASA in preparation for the 2020 Astrophysics Decadal Survey. LUVOIR is a general-purpose space-based observatory with a large aperture in the 8-16 m range and a total bandpass spanning from the far-UV to the near-infrared. This observatory will enable revolutionary new studies in many areas of astronomy, including planetary science within and beyond our Solar System. Because LUVOIR is being considered for the next decadal survey, it must be capable of advancing our understanding of astronomical targets, including exoplanets, far beyond what will be achieved by the next two decades of observations from other space- or ground-based facilities. This means that the mission must move past planet detection, which is happening now with Kepler and ground-based measurements and will continue with TESS (Transiting Exoplanet Survey Satellite) and WFIRST (Wide Field Infrared Survey Telescope). It must also move beyond the chemical characterization of gas giants, which has begun with observations from Spitzer, Hubble, and ground-based telescopes and will greatly advances with the upcoming JWST (James Webb Space Telescope) and WFIRST coronagraph. Therefore, one of LUVOIR's main science objectives will be to directly image rocky Earth-sized planets in the habitable zones of other stars, measure their spectra, analyze the chemistry of their atmospheres, and obtain information about their surfaces. Such observations will allow us to evaluate these worlds' habitability and potential for life. We will review the specific observational strategies needed for astrobiological assessments of exoplanetary environments, including the wavelength range and spectral resolution required for these habitability analyses and biosignature searches. Further, we will discuss how the observational requirements to make measurements of "Earthlike" worlds will allow high-quality observations of a wide

  15. Development of Mirror Modules for the ART-XC Instrument

    Science.gov (United States)

    Gubarev, M.; Ramsey, B.; O'Dell, S. L.; Elsner, R.; Kilaru, K.; McCracken, J.; Pavlinsky, M.; Lapshov, I.

    2012-01-01

    The Marshall Space Flight Center (MSFC) is developing x-ray mirror modules for the ART -XC instrument on board the Spectrum-Roentgen-Gamma Mission under a Reimbursable Agreement between NASA and the Russian Space Research Institute (IKI.) ART-XC will consist of seven co-aligned x-ray mirror modules with seven corresponding CdTe focal plane detectors. Currently, four of the modules are being fabricated by the Marshall Space Flight Center (MSFC.) Each MSFC module provides an effective area of 65 cm2 at 8 keV, response out to 30 keV, and an angular resolution of 45 arcsec or better HPD. We will present a status of the ART x-ray module development at MSFC.

  16. Linking Knowledge and Skills to Mission Essential Competency-Based Syllabus Development for Distributed Mission Operations

    National Research Council Canada - National Science Library

    Symons, Steve; France, Michael; Bell, Jeffrey; Bennett, Jr, Winston

    2006-01-01

    ... of Mission Essential Competencies (MECs). MECs are defined as the higher order individual, team, and inter-team competencies that a fully prepared pilot, crew, or flight requires for successful mission completion under adverse conditions...

  17. Composable Mission Framework for Rapid End-to-End Mission Design and Simulation, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The innovation proposed here is the Composable Mission Framework (CMF) a model-based software framework that shall enable seamless continuity of mission design and...

  18. A university-based distributed satellite mission control network for operating professional space missions

    Science.gov (United States)

    Kitts, Christopher; Rasay, Mike

    2016-03-01

    For more than a decade, Santa Clara University's Robotic Systems Laboratory has operated a unique, distributed, internet-based command and control network for providing professional satellite mission control services for a variety of government and industry space missions. The system has been developed and is operated by students who become critical members of the mission teams throughout the development, test, and on-orbit phases of these missions. The mission control system also supports research in satellite control technology and hands-on student aerospace education. This system serves as a benchmark for its comprehensive nature, its student-centric nature, its ability to support NASA and industry space missions, and its longevity in providing a consistent level of professional services. This paper highlights the unique features of this program, reviews the network's design and the supported spacecraft missions, and describes the critical programmatic features of the program that support the control of professional space missions.

  19. CDC 6600 Cordwood Module

    CERN Multimedia

    1964-01-01

    The CDC 6600 cordwood module containing 64 silicon transistors. The module was mounted between two plates that were cooled conductive by a refrigeration unit via the front panel. The construction of this module uses the cord method, so called because the resistors seem to be stacked like cord between the two circuit boards in order to obtain a high density. The 6600 model contained nearly 6,000 such modules.

  20. Mission Design for NASA's Inner Heliospheric Sentinels and ESA's Solar Orbiter Missions

    Science.gov (United States)

    Downing, John; Folta, David; Marr, Greg; Rodriquez-Canabal, Jose; Conde, Rich; Guo, Yanping; Kelley, Jeff; Kirby, Karen

    2007-01-01

    This paper will document the mission design and mission analysis performed for NASA's Inner Heliospheric Sentinels (IHS) and ESA's Solar Orbiter (SolO) missions, which were conceived to be launched on separate expendable launch vehicles. This paper will also document recent efforts to analyze the possibility of launching the Inner Heliospheric Sentinels and Solar Orbiter missions using a single expendable launch vehicle, nominally an Atlas V 551.

  1. Unresolved Galaxy Classifier for ESA/Gaia mission: Support Vector Machines approach

    Science.gov (United States)

    Bellas-Velidis, Ioannis; Kontizas, Mary; Dapergolas, Anastasios; Livanou, Evdokia; Kontizas, Evangelos; Karampelas, Antonios

    A software package Unresolved Galaxy Classifier (UGC) is being developed for the ground-based pipeline of ESA's Gaia mission. It aims to provide an automated taxonomic classification and specific parameters estimation analyzing Gaia BP/RP instrument low-dispersion spectra of unresolved galaxies. The UGC algorithm is based on a supervised learning technique, the Support Vector Machines (SVM). The software is implemented in Java as two separate modules. An offline learning module provides functions for SVM-models training. Once trained, the set of models can be repeatedly applied to unknown galaxy spectra by the pipeline's application module. A library of galaxy models synthetic spectra, simulated for the BP/RP instrument, is used to train and test the modules. Science tests show a very good classification performance of UGC and relatively good regression performance, except for some of the parameters. Possible approaches to improve the performance are discussed.

  2. Biologic therapy of rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Damjanov Nemanja

    2009-01-01

    Full Text Available Rheumatoid arthritis (RA and juvenile idiopathic/rheumatoid arthritis (JIA are chronic, inflammatory, systemic, auto-immune diseases characterized by chronic arthritis leading to progressive joint erosions. The individual functional and social impact of rheumatoid arthritis is of great importance. Disability and joint damage occur rapidly and early in the course of the disease. The remarkably improved outcomes have been achieved initiating biologic therapy with close monitoring of disease progression. Biologic agents are drugs, usually proteins, which can influence chronic immune dysregulation resulting in chronic arthritis. According to the mechanism of action these drugs include: 1 anti-TNF drugs (etanercept, infiximab, adalimumab; 2 IL-1 blocking drugs (anakinra; 3 IL-6 blocking drugs (tocilizumab; 4 agents blocking selective co-stimulation modulation (abatacept; 5 CD 20 blocking drugs (rituximab. Biologics targeting TNF-alpha with methotrexate have revolutionized the treatment of RA, producing significant improvement in clinical, radiographic, and functional outcomes not seen previously. The new concept of rheumatoid arthritis treatment defines early diagnosis, early aggressive therapy with optimal doses of disease modifying antirheumatic drugs (DMARDs and, if no improvement has been achieved during six months, early introduction of biologic drugs. The three-year experience of biologic therapy in Serbia has shown a positive effect on disease outcome.

  3. Rescue Manual. Module 5.

    Science.gov (United States)

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This learner manual for rescuers covers the current techniques or practices required in the rescue service. The fifth of 10 modules contains information on hazardous materials. Key points, an introduction, and conclusion accompany substantive material in this module. In addition, the module contains a Department of Transportation guide chart on…

  4. Modulating lignin in plants

    Science.gov (United States)

    Apuya, Nestor; Bobzin, Steven Craig; Okamuro, Jack; Zhang, Ke

    2013-01-29

    Materials and methods for modulating (e.g., increasing or decreasing) lignin content in plants are disclosed. For example, nucleic acids encoding lignin-modulating polypeptides are disclosed as well as methods for using such nucleic acids to generate transgenic plants having a modulated lignin content.

  5. QUAD TAG MODULE

    International Nuclear Information System (INIS)

    Shiino, K.; Maruyama, K.

    1981-08-01

    Electronic circuits called QUAD TAG MODULE were developed and constructed, which were of exclusive use for signals from scintillation counter hodoscope of the photon tagging system. The circuit has functions of amplifiers, discriminators, and strobed coincidences in one NIM module. A description on functions and specifications of the module is given. (author)

  6. The LUVOIR Large Mission Concept

    Science.gov (United States)

    O'Meara, John; LUVOIR Science and Technology Definition Team

    2018-01-01

    LUVOIR is one of four large mission concepts for which the NASA Astrophysics Division has commissioned studies by Science and Technology Definition Teams (STDTs) drawn from the astronomical community. We are currently developing two architectures: Architecture A with a 15.1 meter segmented primary mirror, and Architecture B with a 9.2 meter segmented primary mirror. Our focus in this presentation is the Architecture A LUVOIR. LUVOIR will operate at the Sun-Earth L2 point. It will be designed to support a broad range of astrophysics and exoplanet studies. The initial instruments developed for LUVOIR Architecture A include 1) a high-performance optical/NIR coronagraph with imaging and spectroscopic capability, 2) a UV imager and spectrograph with high spectral resolution and multi-object capability, 3) a high-definition wide-field optical/NIR camera, and 4) a high resolution UV/optical spectropolarimeter. LUVOIR will be designed for extreme stability to support unprecedented spatial resolution and coronagraphy. It is intended to be a long-lifetime facility that is both serviceable, upgradable, and primarily driven by guest observer science programs. In this presentation, we will describe the observatory, its instruments, and survey the transformative science LUVOIR can accomplish.

  7. The GeoCARB Mission

    Science.gov (United States)

    Crowell, S.; Moore, B., III; Kumer, J. J.; O'Dell, C.; Rayner, P. J.; Kawa, S. R.

    2015-12-01

    The GeoCARB Mission: Constraining Carbon Emissions from Geostationary Orbit GeoCARB is a high precision greenhouse gas observing system proposed to the recent Earth Venture Instrument (EVI-3) program. The proposed GeoCARB instrument would measure CO2, CH4, CO and O2 using a grating spectrometer with sensitivity in the same bands as OCO-2 for CO2 and O2. With a 2km by 3km footprint at nadir, extremely high resolution observations will be possible at multiple times each day that are fully customizable for different purposes (monitoring, field campaigns, large plume events). In this presentation, we will demonstrate the extraordinary potential for a geostationary mapping instrument to constrain both natural and anthropogenic carbon fluxes at high space and time resolution through the use of OSSEs. This will elucidate the need for an instrument like GeoCARB to tackle the problem of understanding the leading order uncertainties present in the feedbacks between the carbon cycle and climate systems, as well as providing a means by which to verify emissions treaties between nations and smaller geopolitical regions.

  8. NICER: Mission Overview and Status

    Science.gov (United States)

    Arzoumanian, Zaven; Gendreau, Keith C.

    2016-04-01

    NASA's Neutron star Interior Composition Explorer (NICER) mission will explore the structure, dynamics, and energetics of neutron stars through soft X-ray (0.2-12 keV) timing and spectroscopy. An external attached payload on the International Space Station (ISS), NICER is manifested on the Commercial Resupply Services SpaceX-11 flight, with launch scheduled for late 2016. The NICER payload is currently in final integration and environmental testing. Ground calibration has provided robust performance measures of the optical and detector subsystems, demonstrating that the instrument meets or surpasses its effective area, timing resolution, energy resolution, etc., requirements. We briefly describe the NICER hardware, its continuing testing, operations and environment on ISS, and the objectives of NICER's prime mission—including precise radius measurements for a handful of neutron stars to constrain the equation of state of cold, ultra-dense matter. Other contributions at this meeting address specific scientific investigations that are enabled by NICER, for neutron stars in their diverse manifestations as well as for broader X-ray astrophysics through a brief, approved Guest Observer program beginning in 2018.

  9. The Infrared Astronomical Mission AKARI*

    Science.gov (United States)

    Murakami, Hiroshi; Baba, Hajime; Barthel, Peter; Clements, David L.; Cohen, Martin; Doi, Yasuo; Enya, Keigo; Figueredo, Elysandra; Fujishiro, Naofumi; Fujiwara, Hideaki; Fujiwara, Mikio; Garcia-Lario, Pedro; Goto, Tomotsugu; Hasegawa, Sunao; Hibi, Yasunori; Hirao, Takanori; Hiromoto, Norihisa; Hong, Seung Soo; Imai, Koji; Ishigaki, Miho; Ishiguro, Masateru; Ishihara, Daisuke; Ita, Yoshifusa; Jeong, Woong-Seob; Jeong, Kyung Sook; Kaneda, Hidehiro; Kataza, Hirokazu; Kawada, Mitsunobu; Kawai, Toshihide; Kawamura, Akiko; Kessler, Martin F.; Kester, Do; Kii, Tsuneo; Kim, Dong Chan; Kim, Woojung; Kobayashi, Hisato; Koo, Bon Chul; Kwon, Suk Minn; Lee, Hyung Mok; Lorente, Rosario; Makiuti, Sin'itirou; Matsuhara, Hideo; Matsumoto, Toshio; Matsuo, Hiroshi; Matsuura, Shuji; MÜller, Thomas G.; Murakami, Noriko; Nagata, Hirohisa; Nakagawa, Takao; Naoi, Takahiro; Narita, Masanao; Noda, Manabu; Oh, Sang Hoon; Ohnishi, Akira; Ohyama, Youichi; Okada, Yoko; Okuda, Haruyuki; Oliver, Sebastian; Onaka, Takashi; Ootsubo, Takafumi; Oyabu, Shinki; Pak, Soojong; Park, Yong-Sun; Pearson, Chris P.; Rowan-Robinson, Michael; Saito, Toshinobu; Sakon, Itsuki; Salama, Alberto; Sato, Shinji; Savage, Richard S.; Serjeant, Stephen; Shibai, Hiroshi; Shirahata, Mai; Sohn, Jungjoo; Suzuki, Toyoaki; Takagi, Toshinobu; Takahashi, Hidenori; TanabÉ, Toshihiko; Takeuchi, Tsutomu T.; Takita, Satoshi; Thomson, Matthew; Uemizu, Kazunori; Ueno, Munetaka; Usui, Fumihiko; Verdugo, Eva; Wada, Takehiko; Wang, Lingyu; Watabe, Toyoki; Watarai, Hidenori; White, Glenn J.; Yamamura, Issei; Yamauchi, Chisato; Yasuda, Akiko

    2007-10-01

    AKARI, the first Japanese satellite dedicated to infrared astronomy, was launched on 2006 February 21, and started observations in May of the same year. AKARI has a 68.5 cm cooled telescope, together with two focal-plane instruments, which survey the sky in six wavelength bands from the mid- to far-infrared. The instruments also have the capability for imaging and spectroscopy in the wavelength range 2 - 180 micron in the pointed observation mode, occasionally inserted into the continuous survey operation. The in-orbit cryogen lifetime is expected to be one and a half years. The All-Sky Survey will cover more than 90 percent of the whole sky with higher spatial resolution and wider wavelength coverage than that of the previous IRAS all-sky survey. Point source catalogues of the All-Sky Survey will be released to the astronomical community. The pointed observations will be used for deep surveys of selected sky areas and systematic observations of important astronomical targets. These will become an additional future heritage of this mission.

  10. The ADM-Aeolus mission

    Science.gov (United States)

    Endemann, Martin

    2017-11-01

    The Atmospheric Dynamics Mission ADM-Aeolus will make direct measurements of global wind-fields. The aim is to provide global observations of wind profiles with a vertical resolution that will satisfy the requirements of the World Meteorological Organization. The only payload is the Atmospheric Laser Doppler Instrument (ALADIN), a direct detection Doppler lidar operating in the UV. It will determine the wind velocity component normal to the satellite velocity vector. These wind profile measurements will be assimilated into numerical forecasting models to improve the quality of the global three-dimensional wind fields. To make full use of the data, the global wind profile data must be made available to the weather prediction centers in near real time. EADS-Astrium (UK and France) and their subcontractors develop Aeolus and ALADIN. Most subsystems have been completed, and the assembly of the Flight Model is well under way, and proceeding to a launch envisaged in late 2008. Details of ALADIN and several of its subsystems are reported in various papers of this conference.

  11. Planetary protection issues related to human missions to Mars

    Science.gov (United States)

    Debus, A.; Arnould, J.

    2008-09-01

    In accordance with the United Nations Outer Space Treaties [United Nations, Agreement Governing the Activities of States on the Moon and Other Celestial Bodies, UN doc A/RES/34/68, resolution 38/68 of December 1979], currently maintained and promulgated by the Committee on Space Research [COSPAR Planetary Protection Panel, Planetary Protection Policy accepted by the COSPAR Council and Bureau, 20 October 2002, amended 24 March 2005, http://www.cosparhq.org/scistr/PPPolicy.htm], missions exploring the Solar system must meet planetary protection requirements. Planetary protection aims to protect celestial bodies from terrestrial contamination and to protect the Earth environment from potential biological contamination carried by returned samples or space systems that have been in contact with an extraterrestrial environment. From an exobiology perspective, Mars is one of the major targets, and several missions are currently in operation, in transit, or scheduled for its exploration. Some of them include payloads dedicated to the detection of life or traces of life. The next step, over the coming years, will be to return samples from Mars to Earth, with a view to increasing our knowledge in preparation for the first manned mission that is likely to take place within the next few decades. Robotic missions to Mars shall meet planetary protection specifications, currently well documented, and planetary protection programs are implemented in a very reliable manner given that experience in the field spans some 40 years. With regards to sample return missions, a set of stringent requirements has been approved by COSPAR [COSPAR Planetary Protection Panel, Planetary Protection Policy accepted by the COSPAR Council and Bureau, 20 October 2002, amended 24 March 2005, http://www.cosparhq.org/scistr/PPPolicy.htm], and technical challenges must now be overcome in order to preserve the Earth’s biosphere from any eventual contamination risk. In addition to the human dimension of

  12. Evolution of Orion Mission Design for Exploration Mission 1 and 2

    Science.gov (United States)

    Gutkowski, Jeffrey P.; Dawn, Timothy F.; Jedrey, Richard M.

    2016-01-01

    The evolving mission design and concepts of NASA’s next steps have shaped Orion into the spacecraft that it is today. Since the initial inception of Orion, through the Constellation Program, and now in the Exploration Mission frame-work with the Space Launch System (SLS), each mission design concept and pro-gram goal have left Orion with a set of capabilities that can be utilized in many different mission types. Exploration Missions 1 and 2 (EM-1 and EM-2) have now been at the forefront of the mission design focus for the last several years. During that time, different Design Reference Missions (DRMs) were built, analyzed, and modified to solve or mitigate enterprise level design trades to ensure a viable mission from launch to landing. The resulting DRMs for EM-1 and EM-2 were then expanded into multi-year trajectory scans to characterize vehicle performance as affected by variations in Earth-Moon geometry. This provides Orion’s subsystems with stressing reference trajectories to help design their system. Now that Orion has progressed through the Preliminary and Critical Design Reviews (PDR and CDR), there is a general shift in the focus of mission design from aiding the vehicle design to providing mission specific products needed for pre-flight and real time operations. Some of the mission specific products needed include, large quantities of nominal trajectories for multiple monthly launch periods and abort options at any point in the mission for each valid trajectory in the launch window.

  13. Student Trade Missions: An Experiential Learning Opportunity

    Science.gov (United States)

    Audet, Josée; Marcotte, Geneviève

    2018-01-01

    In response to the criticisms addressed to business schools, teaching formulas that foster experiential learning are increasingly being put forward. The Missions Commerciales de l'Université Laval (MCUL--Université Laval Trade Missions) is a training program designed to foster experiential learning. This program extends over an entire academic…

  14. The IRIS Mission: A Colorful EPO Program

    Science.gov (United States)

    Scherrer, Deborah K.

    2012-05-01

    We will overview NASA’s IRIS mission EPO program, which includes a nationwide spectroscopy contest, K-12 resources, a summer program for undergraduates, informal outreach elements, and a dynamic social media program based on the highly successful Camilla/Little SDO program for NASA’s SDO mission.

  15. Radiation Hardness Assurance (RHA) for Small Missions

    Science.gov (United States)

    Campola, Michael J.

    2016-01-01

    Varied mission life and complexity is growing for small spacecraft. Small missions benefit from detailed hazard definition and evaluation as done in the past. Requirements need to flow from the system down to the parts level and aid system level radiation tolerance. RHA is highlighted with increasing COTS usage.

  16. Core Science Systems--Mission overview

    Science.gov (United States)

    Gallagher, Kevin T.

    2012-01-01

    The Core Science Systems Mission Area delivers nationally focused Earth systems and information science that provides fundamental research and data that underpins all Mission Areas of the USGS, the USGS Science Strategy, and Presidential, Secretarial, and societal priorities. —Kevin T. Gallagher, Associate Director, Core Science Systems

  17. Tank waste remediation system mission analysis report

    International Nuclear Information System (INIS)

    Acree, C.D.

    1998-01-01

    The Tank Waste Remediation System Mission Analysis Report identifies the initial states of the system and the desired final states of the system. The Mission Analysis Report identifies target measures of success appropriate to program-level accomplishments. It also identifies program-level requirements and major system boundaries and interfaces

  18. Growing fresh food on future space missions

    NARCIS (Netherlands)

    Meinen, Esther; Dueck, Tom; Kempkes, Frank; Stanghellini, Cecilia

    2018-01-01

    This paper deals with vegetable cultivation that could be faced in a space mission. This paper focusses on optimization, light, temperature and the harvesting process, while other factors concerning cultivation in space missions, i.e. gravity, radiation, were not addressed. It describes the work

  19. ACTS FOR TODAY 'S MISSIONAL CHURCH

    African Journals Online (AJOL)

    2010-01-30

    Jan 30, 2010 ... a journey through Acts, exploring this important contemporary text in the development of a missional ecclesiology. The ability of the ... the expectation that the book of Acts can inform significantly today's missional church in retooling itself ... transformation experience Acts as particularly helpful and relevant?'.

  20. Identification mission on Antimicrobial resistance in Indonesia

    NARCIS (Netherlands)

    Claassen, I.J.T.M.; Wagenaar, J.A.; Schreijer, Anja

    2015-01-01

    This report contains the findings and recommendations on antimicrobial use (AMU) and antimicrobial resistance (AMR) practice and policies in Indonesia.
    The observations were made by a team of Dutch and Indonesian experts during an identification mission in August 2015. The mission did address