WorldWideScience

Sample records for biologics research projects

  1. Space Station Biological Research Project Habitat: Incubator

    Science.gov (United States)

    Nakamura, G. J.; Kirven-Brooks, M.; Scheller, N. M.

    2001-01-01

    Developed as part of the suite of Space Station Biological Research Project (SSBRP) hardware to support research aboard the International Space Station (ISS), the Incubator is a temperature-controlled chamber, for conducting life science research with small animal, plant and microbial specimens. The Incubator is designed for use only on the ISS and is transported to/from the ISS, unpowered and without specimens, in the Multi-Purpose Logistics Module (MPLM) of the Shuttle. The Incubator interfaces with the three SSBRP Host Systems; the Habitat Holding Racks (HHR), the Life Sciences Glovebox (LSG) and the 2.5 m Centrifuge Rotor (CR), providing investigators with the ability to conduct research in microgravity and at variable gravity levels of up to 2-g. The temperature within the Specimen Chamber can be controlled between 4 and 45 C. Cabin air is recirculated within the Specimen Chamber and can be exchanged with the ISS cabin at a rate of approximately equal 50 cc/min. The humidity of the Specimen Chamber is monitored. The Specimen Chamber has a usable volume of approximately equal 19 liters and contains two (2) connectors at 28v dc, (60W) for science equipment; 5 dedicated thermometers for science; ports to support analog and digital signals from experiment unique sensors or other equipment; an Ethernet port; and a video port. It is currently manifested for UF-3 and will be launched integrated within the first SSBRP Habitat Holding Rack.

  2. Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

    Directory of Open Access Journals (Sweden)

    Rabus Hans

    2014-01-01

    Full Text Available Funded within the European Metrology Research Programme (EMRP [1], the joint research projectBiologically weighted quantities in radiotherapy” (BioQuaRT [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm, and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS. Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

  3. Team Research at the Biology-Mathematics Interface: Project Management Perspectives

    Science.gov (United States)

    Milton, John G.; Radunskaya, Ami E.; Lee, Arthur H.; de Pillis, Lisette G.; Bartlett, Diana F.

    2010-01-01

    The success of interdisciplinary research teams depends largely upon skills related to team performance. We evaluated student and team performance for undergraduate biology and mathematics students who participated in summer research projects conducted in off-campus laboratories. The student teams were composed of a student with a mathematics…

  4. Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers

    Energy Technology Data Exchange (ETDEWEB)

    Jurisson, Silvia S. [Univ. of Missouri, Columbia, MO (United States); Lever, Susan Z. [Univ. of Missouri, Columbia, MO (United States); Robertson, J. David [Univ. of Missouri, Columbia, MO (United States)

    2016-10-04

    This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.

  5. Overview of research in radiation biology and protective measures in the Manhattan Project during the war years, 1942-1946

    International Nuclear Information System (INIS)

    The objecitve was to present a cohesive view of the general biological research program associated with the Manhattan Project. The material is arrangd in chronological order. Each of the major research sites is identified and the general nature of their research program indicated. A section is devoted to the question of the various radiation limits which were used in the operational approach to hazard controls

  6. Connecting Biology and Organic Chemistry Introductory Laboratory Courses through a Collaborative Research Project

    Science.gov (United States)

    Boltax, Ariana L.; Armanious, Stephanie; Kosinski-Collins, Melissa S.; Pontrello, Jason K.

    2015-01-01

    Modern research often requires collaboration of experts in fields, such as math, chemistry, biology, physics, and computer science to develop unique solutions to common problems. Traditional introductory undergraduate laboratory curricula in the sciences often do not emphasize connections possible between the various disciplines. We designed an…

  7. DOE Final Technical Report (2009-2016): "Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers"

    Energy Technology Data Exchange (ETDEWEB)

    Jurisson, Silvia [University of Missouri-Columbia; Lever, Susan [University of Missouri-Columbia; Robertson, J. David [University of Missouri-Columbia

    2016-10-04

    This is the final technical report for DOE grant DE-SC-0002040, which was entitled "Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers". Included are the students and postdoctoral fellows trained, the publications, dissertations, presentations, and other deliverables for this project.

  8. A Research Project-Based and Self-Determined Teaching System of Molecular Biology Techniques for Undergraduates

    Science.gov (United States)

    Zhang, Shuping

    2008-01-01

    Molecular biology techniques play a very important role in understanding the biological activity. Students who major in biology should know not only how to perform experiments, but also the reasons for performing them. Having the concept of conducting research by integrating various techniques is especially important. This paper introduces a…

  9. Biological Databases for Human Research

    Institute of Scientific and Technical Information of China (English)

    Dong Zou; Lina Ma; Jun Yu; Zhang Zhang

    2015-01-01

    The completion of the Human Genome Project lays a foundation for systematically studying the human genome from evolutionary history to precision medicine against diseases. With the explosive growth of biological data, there is an increasing number of biological databases that have been developed in aid of human-related research. Here we present a collection of human-related biological databases and provide a mini-review by classifying them into different categories according to their data types. As human-related databases continue to grow not only in count but also in volume, challenges are ahead in big data storage, processing, exchange and curation.

  10. Integrating Biology & Math in an Inquiry-Based Student Research Project

    Science.gov (United States)

    Bakke, Leanne; Kieke, Michele C.; Krueger, Robert

    2013-01-01

    In daily life, students are allowed to use words such as "more," "some," or "increase-decrease" to describe the relationship between two events. In science, concise description is necessary, which requires the contribution of math. In the summer component of the Science Research Institute program, students integrated…

  11. Biologically inspired technologies in NASA's morphing project

    Science.gov (United States)

    McGowan, Anna-Maria R.; Cox, David E.; Lazos, Barry S.; Waszak, Martin R.; Raney, David L.; Siochi, Emilie J.; Pao, S. Paul

    2003-07-01

    For centuries, biology has provided fertile ground for hypothesis, discovery, and inspiration. Time-tested methods used in nature are being used as a basis for several research studies conducted at the NASA Langley Research Center as a part of Morphing Project, which develops and assesses breakthrough vehicle technologies. These studies range from low drag airfoil design guided by marine and avian morphologies to soaring techniques inspired by birds and the study of small flexible wing vehicles. Biology often suggests unconventional yet effective approaches such as non-planar wings, dynamic soaring, exploiting aeroelastic effects, collaborative control, flapping, and fibrous active materials. These approaches and other novel technologies for future flight vehicles are being studied in NASA's Morphing Project. This paper will discuss recent findings in the aeronautics-based, biologically-inspired research in the project.

  12. Publications of the planetary biology program for 1975: A special bibliography. [on NASA programs and research projects on extraterrestrial life

    Science.gov (United States)

    Souza, K. A. (Compiler); Young, R. S. (Compiler)

    1976-01-01

    The Planetary Biology Program of the National Aeronautics and Space Administration is the first and only integrated program to methodically investigate the planetary events which may have been responsible for, or related to, the origin, evolution, and distribution of life in the universe. Research supported by this program is divided into the seven areas listed below: (1) chemical evolution, (2) organic geochemistry, (3) life detection, (4) biological adaptation, (5) bioinstrumentation, (6) planetary environments, and (7) origin of life. The arrangement of references in this bibliography follows the division of research described above. Articles are listed alphabetically by author under the research area with which they are most closely related. Only those publications which resulted from research supported by the Planetary Biology Program and which bear a 1975 publication date have been included. Abstracts and theses are not included because of the preliminary and abbreviated nature of the former and the frequent difficulty of obtaining the latter.

  13. Architectural project and research

    DEFF Research Database (Denmark)

    Lotz, Katrine

    2005-01-01

    Discussion of criterias for research including the researchers or designers own project as theme.......Discussion of criterias for research including the researchers or designers own project as theme....

  14. Basic research projects

    Energy Technology Data Exchange (ETDEWEB)

    1979-04-01

    The research programs under the cognizance of the Office of Energy Research (OER) are directed toward discovery of natural laws and new knowledge, and to improved understanding of the physical and biological sciences as related to the development, use, and control of energy. The ultimate goal is to develop a scientific underlay for the overall DOE effort and the fundamental principles of natural phenomena so that these phenomena may be understood, and new principles, formulated. The DOE-OER outlay activities include three major programs: High Energy Physics, Nuclear Physics, and Basic Energy Sciences. Taken together, these programs represent some 30 percent of the Nation's Federal support of basic research in the energy sciences. The research activities of OER involve more than 6,000 scientists and engineers working in some 17 major Federal Research Centers and at more than 135 different universities and industrial firms throughout the United States. Contract holders in the areas of high-energy physics, nuclear physics, materials sciences, nuclear science, chemical sciences, engineering, mathematics geosciences, advanced energy projects, and biological energy research are listed. Funding trends for recent years are outlined. (RWR)

  15. Basic research projects

    International Nuclear Information System (INIS)

    The research programs under the cognizance of the Office of Energy Research (OER) are directed toward discovery of natural laws and new knowledge, and to improved understanding of the physical and biological sciences as related to the development, use, and control of energy. The ultimate goal is to develop a scientific underlay for the overall DOE effort and the fundamental principles of natural phenomena so that these phenomena may be understood, and new principles, formulated. The DOE-OER outlay activities include three major programs: High Energy Physics, Nuclear Physics, and Basic Energy Sciences. Taken together, these programs represent some 30 percent of the Nation's Federal support of basic research in the energy sciences. The research activities of OER involve more than 6,000 scientists and engineers working in some 17 major Federal Research Centers and at more than 135 different universities and industrial firms throughout the United States. Contract holders in the areas of high-energy physics, nuclear physics, materials sciences, nuclear science, chemical sciences, engineering, mathematics geosciences, advanced energy projects, and biological energy research are listed. Funding trends for recent years are outlined

  16. Life sciences space biology project planning

    Science.gov (United States)

    Primeaux, G.; Newkirk, K.; Miller, L.; Lewis, G.; Michaud, R.

    1988-01-01

    The Life Sciences Space Biology (LSSB) research will explore the effect of microgravity on humans, including the physiological, clinical, and sociological implications of space flight and the readaptations upon return to earth. Physiological anomalies from past U.S. space flights will be used in planning the LSSB project.The planning effort integrates science and engineering. Other goals of the LSSB project include the provision of macroscopic view of the earth's biosphere, and the development of spinoff technology for application on earth.

  17. Space Station Biological Research Project (SSBRP) Cell Culture Unit (CCU) and incubator for International Space Station (ISS) cell culture experiments

    Science.gov (United States)

    Vandendriesche, Donald; Parrish, Joseph; Kirven-Brooks, Melissa; Fahlen, Thomas; Larenas, Patricia; Havens, Cindy; Nakamura, Gail; Sun, Liping; Krebs, Chris; de Luis, Javier; Vunjak-Novakovic, Gordana; Searby, Nancy D.

    2004-01-01

    The CCU and Incubator are habitats under development by SSBRP for gravitational biology research on ISS. They will accommodate multiple specimen types and reside in either Habitat Holding Racks, or the Centrifuge Rotor, which provides selectable gravity levels of up to 2 g. The CCU can support multiple Cell Specimen Chambers, CSCs (18, 9 or 6 CSCs; 3, 10 or 30 mL in volume, respectively). CSCs are temperature controlled from 4-39 degrees C, with heat shock to 45 degrees C. CCU provides automated nutrient supply, magnetic stirring, pH/O2 monitoring, gas supply, specimen lighting, and video microscopy. Sixty sample containers holding up to 2 mL each, stored at 4-39 degrees C, are available for automated cell sampling, subculture, and injection of additives and fixatives. CSCs, sample containers, and fresh/spent media bags are crew-replaceable for long-term experiments. The Incubator provides a 4-45 degrees C controlled environment for life science experiments or storage of experimental reagents. Specimen containers and experiment unique equipment are experimenter-provided. The Specimen Chamber exchanges air with ISS cabin and has 18.8 liters of usable volume that can accommodate six trays and the following instrumentation: five relocatable thermometers, two 60 W power outlets, four analog ports, and one each relative humidity sensor, video port, ethernet port and digital input/output port.

  18. Space Station Biological Research Project (SSBRP) Cell Culture Unit (CCU) and incubator for International Space Station (ISS) cell culture experiments.

    Science.gov (United States)

    Vandendriesche, Donald; Parrish, Joseph; Kirven-Brooks, Melissa; Fahlen, Thomas; Larenas, Patricia; Havens, Cindy; Nakamura, Gail; Sun, Liping; Krebs, Chris; de Luis, Javier; Vunjak-Novakovic, Gordana; Searby, Nancy D

    2004-03-01

    The CCU and Incubator are habitats under development by SSBRP for gravitational biology research on ISS. They will accommodate multiple specimen types and reside in either Habitat Holding Racks, or the Centrifuge Rotor, which provides selectable gravity levels of up to 2 g. The CCU can support multiple Cell Specimen Chambers, CSCs (18, 9 or 6 CSCs; 3, 10 or 30 mL in volume, respectively). CSCs are temperature controlled from 4-39 degrees C, with heat shock to 45 degrees C. CCU provides automated nutrient supply, magnetic stirring, pH/O2 monitoring, gas supply, specimen lighting, and video microscopy. Sixty sample containers holding up to 2 mL each, stored at 4-39 degrees C, are available for automated cell sampling, subculture, and injection of additives and fixatives. CSCs, sample containers, and fresh/spent media bags are crew-replaceable for long-term experiments. The Incubator provides a 4-45 degrees C controlled environment for life science experiments or storage of experimental reagents. Specimen containers and experiment unique equipment are experimenter-provided. The Specimen Chamber exchanges air with ISS cabin and has 18.8 liters of usable volume that can accommodate six trays and the following instrumentation: five relocatable thermometers, two 60 W power outlets, four analog ports, and one each relative humidity sensor, video port, ethernet port and digital input/output port.

  19. Cooperative Market Research Project.

    Science.gov (United States)

    Carels, Peter; McCullough, Lynette

    A pilot project was developed in which the Advertising and Market Research Center of the Vienna School of Economics and Business in Austria and the German Department as well as the Marketing Department of Miami University in Ohio are working together to collect market research data and formulate a market entry strategy for Roemerquelle, an…

  20. Biologically Inspired Micro-Flight Research

    Science.gov (United States)

    Raney, David L.; Waszak, Martin R.

    2003-01-01

    Natural fliers demonstrate a diverse array of flight capabilities, many of which are poorly understood. NASA has established a research project to explore and exploit flight technologies inspired by biological systems. One part of this project focuses on dynamic modeling and control of micro aerial vehicles that incorporate flexible wing structures inspired by natural fliers such as insects, hummingbirds and bats. With a vast number of potential civil and military applications, micro aerial vehicles represent an emerging sector of the aerospace market. This paper describes an ongoing research activity in which mechanization and control concepts for biologically inspired micro aerial vehicles are being explored. Research activities focusing on a flexible fixed- wing micro aerial vehicle design and a flapping-based micro aerial vehicle concept are presented.

  1. Researchers Discover Plants Biological Clock

    Institute of Scientific and Technical Information of China (English)

    王全良

    1996-01-01

    Scientists who created glow-in-the-dark plants by shooting up seedlingswith firefly DNA have identified the first biological clock gene in plants. Discovery of the timepiece gene, which controls such biological rhythmsas daily leaf movements and proe openings, flower-blooming schedules andphotosynthesis cycles, could lead to a host of applications in ornamental horti-culture, agriculture and even human health. Many researchers believe that

  2. Catalogue of research projects

    International Nuclear Information System (INIS)

    The Centre for Materials Science serves as an umbrella for organizations involved in materials research at the two Universities and at certain branch institutes in the Gothenburg region. The general goal of the Centre is to promote materials research among the member organizations and to provide a link to industry and to the society at large. Members of the Centre work on most aspects of modern materials research, ranging from single-atom manipulation and theoretical simulations to biomaterials and production engineering. In order to give a presentation of the members and their research, the Centre produces an inventory of materials research projects approximately every four years. The 1993 issue is somewhat more extensive than previous editions, detailing e.g. also scientific equipment and listing work published during the past four years. The register covers the following main headings: General materials and surface science; Materials chemistry; Polymers and fibres; Biomaterials; Clusters and fine particles; Electronic and opto-electronic materials; Superconductors and nanometer structures; Ceramics; Metals; Building materials; Production and materials processing

  3. The Human Genome Project and biology education

    Energy Technology Data Exchange (ETDEWEB)

    McInerney, J.D. [Biological Sciences Curriculum Study, Colorado Springs, CO (United States)

    1995-12-01

    Within the last several years, biologists celebrated the fortieth anniversary of the Watson-Crick model of DNA and the fiftieth anniversary of the demonstration that DNA is the genetic material, discoveries that began a pervasive and ongoing revolution in biology and medicine. Nobelist Joshua Lederberg, for example, called the work of Avery`s group {open_quotes}the most important discovery in biology in the twentieth century.{close_quotes} This early work on DNA also contributed to a revolution in biology education, beginning in the 1960s. Like the biological revolution that is its counterpart, however, the educational revolution is incomplete, in part because the science continues to evolve, but primarily because scientists and science educators have not yet responded completely to the challenges of genetics and molecular biology. These challenges are made even more obvious by the scope and visibility of the Human Genome Project, the international project intended to map and sequence all human genes. Science educators face 4 challenges discussed in this article and using the Genome project as an example: teach for conceptual understanding; the nature of science; the personal and social impact of science and technology; the principles of technology.

  4. Biological Psychiatry, Research And Industry

    Directory of Open Access Journals (Sweden)

    Ajai R. Singh

    2007-01-01

    Full Text Available In this section, we look at how the biological paradigm shift in psychiatry has been aided and abetted by industry for serving its own needs; which stymies other promising approaches; but which, nonetheless, can serve to advance biomedicine if checks and balances are in place. Industry, Biological Psychiatry And Non-pharmacological Advance The larger issue of benefit to society also concerns us when we realize that industry sponsorship is mainly for potential medications, not for trying to determine whether there may be non-pharmacological interventions that may be equally good, if not better. …a lack of balance in research activities, with a focus mainly on potential medications, is likely to divert talented researchers from the pursuit of profound scientific questions or divert them from the pursuit of questions without market relevance but with an aspect of public good. A company has little incentive to support trials evaluating whether inexpensive, off-patent drugs or whether non-pharmaceutical interventions, could replace their profitable patented drug (Baird, 2003 This is the reason why methods like yoga, psychotherapy, meditation, non-medicated non-mechanised relaxation will not find industry sponsors readily and may never be proved useful apart from anecdotal reporting.In which case to expect industry sponsorship to develop a larger therapeutic armamentarium, especially non-drug based, is wishful thinking. Moreover, non-pharmacological treatment procedures may not get desirable funding. This may not be as much of a problem in other branches of medicine as in psychiatry, wherein non-pharmacological interventions like psychotherapy still hold promise of therapeutic relief.If we do not see rigorous experimental research in psychotherapy or other non-drug modalities to the extent that we should, let us be careful before blaming the researchers for it. Where are the funds? Also, let us note that behind the great thrust towards Biological

  5. Enhancing Biology Instruction with the Human Genome Project

    Science.gov (United States)

    Buxeda, Rosa J.; Moore-Russo, Deborah A.

    2003-01-01

    The Human Genome Project (HGP) is a recent scientific milestone that has received notable attention. This article shows how a biology course is using the HGP to enhance students' experiences by providing awareness of cutting edge research, with information on new emerging career options, and with opportunities to consider ethical questions raised…

  6. Initiatives in biological research in Indian psychiatry

    OpenAIRE

    Shrivatava, Amresh

    2010-01-01

    Biological psychiatry is an exploratory science for mental health. These biological changes provide some explicit insight into the complex area of ‘brain-mind and behavior’. One major achievement of research in biological field is the finding to explain how biological factors cause changes in behavior. In India, we have a clear history of initiatives in research from a biological perspective, which goes back to 1958. In the last 61 years, this field has seen significant evolution, precision a...

  7. Gamification in citizen science: Projects in particle physics and synthetic biology

    OpenAIRE

    Jennett, C.; Iacovides, I.; Skands, P.; Shomar, H.; Cox, A. L.

    2013-01-01

    We present two new citizen cyberscience projects that are being developed in the research fields of Particle Physics and Synthetic Biology, and discuss several issues to be considered in relation to the gamification of these projects.

  8. Biology Education Research: Lessons and Future Directions

    OpenAIRE

    Singer, Susan R.; Nielsen, Natalie R.; Schweingruber, Heidi A.

    2013-01-01

    This feature draws on a 2012 National Research Council report to highlight some of the insights that discipline-based education research in general—and biology education research in particular—have provided into the challenges of undergraduate science education. It identifies strategies for overcoming those challenges and future directions for biology education research.

  9. Biological Research for Radiation Protection

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Gyu; Kim, Kug Chan; Jung, Il Lae; Choi, Yong Ho; Kim, Jin Sik; Moon, Myung Sook; Byun, Hee Sun; Phyo, Ki Heon; Kim, Sung Keun

    2005-04-15

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H{sub 2}O{sub 2}(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H{sub 2}O{sub 2})-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H{sub 2}O{sub 2}(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell protecting effects. Based on the above result, we suggest that the express regulation of theses genes have potentially importance for sensitizing the efficiency of radiation therapy of cancer or for protecting the radiation-induced damage of normal cells.

  10. Biological Research for Radiation Protection

    International Nuclear Information System (INIS)

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H2O2(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H2O2)-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H2O2(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell protecting effects. Based on the above result, we suggest that the express regulation of theses genes have potentially importance for sensitizing the efficiency of radiation therapy of cancer or for protecting the radiation-induced damage of normal cells

  11. Biological research for radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Gyu; Kim, Kug Chan; Shim, Hae Won; Oh, Tae Jeong; Park, Seon Young; Lee, Kang Suk

    2000-04-01

    The work scope of Biological research for the radiation protection had contained the search of biological microanalytic methods for assessing the health effect by {gamma}-radiation and toxic agents, the standardization of human T-lymphocyte cell culture and polymerase chain reaction, T-cell clonal assay, and the quantification of mutation frequency in the hypoxanthine (guanine) phosphoribosyl transferase (HPRT) gene locus by single exposure or combined exposure. Especially, the polymerase chain reaction methods using reverse transcriptase has been developed to analyze the mutant gene induced by {gamma}-radiation and chemical (pentachlorophenol) agent exposure, and to investigate the point mutations in the HPRT gene locus of T-lymphocytes. The HPRT T-cell clonal assay revealed that it could not differentiate {gamma}-irradiation from pentachlorophenol, because the frequency of somatic mutations induced by both damaging agents increased in a dose-dependent manner. The analysis of DNA sequence alterations of HPRT mutant clones clearly showed that both damaging agents induced different mutational spectra in the HPRT locus of T-cells. The large deletions, which account for 75 percent of the analyzed mutants, are characteristic mutations induced by {gamma}-irradiation. By contrast, point mutations such as base substitutions and insertion, come up to 97 percent in the case of pentachlorophenol-treated cells. The point mutation frequencies at 190 base pair and 444 base pair positions are 3-6 folds as high as in those at other mutation positions. It may be that these mutation sites are hot spots induced by pentachlorophenol. These results suggest that the HPRT mutation spectrum can be used as a potential bio marker for assessing a specific environmental risk. (author)

  12. Biological research for radiation protection

    International Nuclear Information System (INIS)

    The work scope of Biological research for the radiation protection had contained the search of biological microanalytic methods for assessing the health effect by γ-radiation and toxic agents, the standardization of human T-lymphocyte cell culture and polymerase chain reaction, T-cell clonal assay, and the quantification of mutation frequency in the hypoxanthine (guanine) phosphoribosyl transferase (HPRT) gene locus by single exposure or combined exposure. Especially, the polymerase chain reaction methods using reverse transcriptase has been developed to analyze the mutant gene induced by γ-radiation and chemical (pentachlorophenol) agent exposure, and to investigate the point mutations in the HPRT gene locus of T-lymphocytes. The HPRT T-cell clonal assay revealed that it could not differentiate γ-irradiation from pentachlorophenol, because the frequency of somatic mutations induced by both damaging agents increased in a dose-dependent manner. The analysis of DNA sequence alterations of HPRT mutant clones clearly showed that both damaging agents induced different mutational spectra in the HPRT locus of T-cells. The large deletions, which account for 75 percent of the analyzed mutants, are characteristic mutations induced by γ-irradiation. By contrast, point mutations such as base substitutions and insertion, come up to 97 percent in the case of pentachlorophenol-treated cells. The point mutation frequencies at 190 base pair and 444 base pair positions are 3-6 folds as high as in those at other mutation positions. It may be that these mutation sites are hot spots induced by pentachlorophenol. These results suggest that the HPRT mutation spectrum can be used as a potential bio marker for assessing a specific environmental risk. (author)

  13. The Biological Flight Research Facility

    Science.gov (United States)

    Johnson, Catherine C.

    1993-01-01

    NASA Ames Research Center (ARC) is building a research facility, the Biological Flight Research Facility (BFRF), to meet the needs of life scientists to study the long-term effects of variable gravity on living systems. The facility will be housed on Space Station Freedom and is anticipated to operate for the lifetime of the station, approximately thirty years. It will allow plant and animal biologists to study the role of gravity, or its absence, at varying gravity intensities for varying periods of time and with various organisms. The principal difference between current Spacelab missions and those on Space Station Freedom, other than length of mission, will be the capability to perform on-orbit science procedures and the capability to simulate earth gravity. Initially the facility will house plants and rodents in habitats which can be maintained at microgravity or can be placed on a 2.5 meter diameter centrifuge. However, the facility is also being designed to accommodate future habitats for small primates, avian, and aquatic specimens. The centrifuge will provide 1 g for controls and will also be able to provide gravity from 0.01 to 2.0 g for threshold gravity studies as well as hypergravity studies. Included in the facility are a service unit for providing clean chambers for the specimens and a glovebox for manipulating the plant and animal specimens and for performing experimental protocols. The BFRF will provide the means to conduct basic experiments to gain an understanding of the effects of microgravity on the structure and function of plants and animals, as well as investigate the role of gravity as a potential countermeasure for the physiological changes observed in microgravity.

  14. Biology Education Research 2.0

    OpenAIRE

    Dolan, Erin L.

    2015-01-01

    Biology education research (BER) 2.0 has arrived, and is moving the BER community beyond showing that active learning works to understanding the individual and contextual factors that explain and influence biology teaching and learning.

  15. Experimental Plasma Research project summaries

    International Nuclear Information System (INIS)

    This report contains descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Diagnostics; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report

  16. Experimental plasma research project summaries

    Energy Technology Data Exchange (ETDEWEB)

    1978-08-01

    This report contans descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Measurements and Instrumentation; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report.

  17. Experimental Plasma Research project summaries

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-09-01

    This report contains descriptions of the activities supported by the Experimental Plasma Research Branch of APP. The individual project summaries were prepared by the principal investigators and include objectives and milestones for each project. The projects are arranged in six research categories: Plasma Properties; Plasma Heating; Plasma Diagnostics; Atomic, Molecular and Nuclear Physics; Advanced Superconducting Materials; and the Fusion Plasma Research Facility (FPRF). Each category is introduced with a statement of objectives and recent progress and followed by descriptions of individual projects. An overall budget summary is provided at the beginning of the report.

  18. Structural Biology and Molecular Applications Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research and development in this area focuses on enabling technologies, models, and methodologies to support basic and applied cancer research.

  19. Research: Projects - MSHN

    OpenAIRE

    Naval Postgraduate School (U.S.); Center for Information Systems Studies Security and Research (CISR)

    2011-01-01

    The Management System for Heterogeneous Networks (MSHN) project is part of the DARPA/ITO Quorum program. Quorum's goal is to develop technologies to allow mission-critical defense applications to achieve survivable, predictable, and controllable quality of service on a globally managed pool of distributed resources.

  20. Research Status of Molecular Biology in Flax

    Institute of Scientific and Technical Information of China (English)

    Wu Jian-zhong

    2016-01-01

    Flax is a kind of worldwide fiber and oil crops, and it has a very important role in economic crop production in the world. With the development of molecular biology techniques, the research of flax molecular level has a very big breakthrough. But, flax molecular biology researches are less reported due to the later starting. This paper summarized the latest research progress of molecular biology of flax, including molecular marker technology, construction of genetic map, gene engineering and omics researches, in order to provide the reference to understand the development and research status for flax molecular breeding researchers.

  1. Biology Education Research: Lessons and Future Directions

    Science.gov (United States)

    Singer, Susan R.; Nielsen, Natalie R.; Schweingruber, Heidi A.

    2013-01-01

    Biologists have long been concerned about the quality of undergraduate biology education. Over time, however, biology faculty members have begun to study increasingly sophisticated questions about teaching and learning in the discipline. These scholars, often called biology education researchers, are part of a growing field of inquiry called…

  2. Experimental Plasma Research. Project summaries

    International Nuclear Information System (INIS)

    This is the fifth in a series of Project Summary books going back to 1976. They are issued approximately every two years and provide a short description of each project supported by the Experimental Plasma Research Branch of the Division of Applied Plasma Physics in the Office of Fusion Energy

  3. Current research in Canada on biological effects of ionizing radiation

    International Nuclear Information System (INIS)

    A survey of current research in Canada on the biological effects of ionizing radiation has been compiled. The list of projects has been classified according to structure (organizational state of the test system) as well as according to the type of effects. Using several assumptions, ballpark estimates of expenditures on these activities have been made. Agencies funding these research activities have been tabulated and the break-down of research in government laboratories and in academic institutions has been designated. Wherever possible, comparisons have been made outlining differences or similarities that exist between the United States and Canada concerning biological radiation research. It has been concluded that relevant research in this area in Canada is inadequate. Wherever possible, strengths and weaknesses in radiation biology programs have been indicated. The most promising course for Canada to follow is to support adequately fundamental studies of the biological effects of radiation. (auth)

  4. Learning Cell Biology as a Team: A Project-Based Approach to Upper-Division Cell Biology

    Science.gov (United States)

    Wright, Robin; Boggs, James

    2002-01-01

    To help students develop successful strategies for learning how to learn and communicate complex information in cell biology, we developed a quarter-long cell biology class based on team projects. Each team researches a particular human disease and presents information about the cellular structure or process affected by the disease, the cellular…

  5. Math Fact Strategies Research Project

    Science.gov (United States)

    Boso, Annie

    2011-01-01

    An action research project was conducted in order to determine effective math fact strategies for first graders. The traditional way of teaching math facts included using timed tests and flashcards, with most students counting on their fingers or a number line. Six new research-based strategies were taught and analyzed to decide which methods…

  6. Experimental plasma research project summaries

    International Nuclear Information System (INIS)

    The experimental plasma Research Branch has responsibility for developing a broad range of experimental data and new experimental techniques that are required for operating and interpreting present large-scale confinement experiments, and for designing future deuterium-tritium burining facilities. The Branch pursued these objectives by supporting research in DOE laboratories, other Federal laboratories, other Federal laboratories, universities, and private industry. Initiation and renewal of research projects are primarily through submission of unsolicited proposals by these institutions to DOE. Summaries of these projects are given

  7. Initiatives in biological research in Indian psychiatry.

    Science.gov (United States)

    Shrivatava, Amresh

    2010-01-01

    Biological psychiatry is an exploratory science for mental health. These biological changes provide some explicit insight into the complex area of 'brain-mind and behavior'. One major achievement of research in biological field is the finding to explain how biological factors cause changes in behavior. In India, we have a clear history of initiatives in research from a biological perspective, which goes back to 1958. In the last 61 years, this field has seen significant evolution, precision and effective utilization of contemporary technological advances. It is a matter of great pride to see that in spite of difficult times in terms of challenges of practice and services, administration, resource, funding and manpower the zest for research was very forthcoming. There was neither dedicated time nor any funding for conducting research. It came from the intellectual insight of our fore fathers in the field of mental health to gradually grow to the state of strategic education in research, training in research, international research collaborations and setting up of internationally accredited centers. During difficult economic conditions in the past, the hypothesis tested and conclusions derived have not been so important. It is more important how it was done, how it was made possible and how robust traditions were established. Almost an entire spectrum of biological research has been touched upon by Indian researchers. Some of these are electroconvulsive therapy, biological markers, neurocognition, neuroimaging, neuroendocrine, neurochemistry, electrophysiology and genetics. A lot has been published given the limited space in the Indian Journal of Psychiatry and other medical journals published in India. A large body of biological research conducted on Indian patients has also been published in International literature (which I prefer to call non-Indian journals). Newer research questions in biological psychiatry, keeping with trend of international standards are

  8. Advanced Energy Projects FY 1996 research summaries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    The mission of the Advanced Energy Projects Division (AEP) is to explore the scientific feasibility of novel energy-related concepts. These concepts are typically at an early stage of scientific development and, therefore, are premature for consideration by applied research or technology development programs. The portfolio of projects is dynamic, but reflects the broad role of the Department in supporting research and development for improving the Nation`s energy posture. Topical areas presently receiving support include: alternative energy sources; innovative concepts for energy conversion and storage; alternate pathways to energy efficiency; exploring uses of new scientific discoveries; biologically-based energy concepts; renewable and biodegradable materials; novel materials for energy technology; and innovative approaches to waste treatment and reduction. Summaries of the 70 projects currently being supported are presented. Appendices contain budget information and investigator and institutional indices.

  9. 20% Research & Design Science Project

    Science.gov (United States)

    Spear, Beth A.

    2015-04-01

    A project allowing employees to use 15 % of their time on independent projects was established at 3M in the 1950's. The result of this project included products like post it notes and masking tape. Google allows its employees to use 20% of their time on independently pursued projects. The company values creativity and innovation. Employees are allowed to explore projects of interest to them one day out of the week, 20 % of their work week. Products like AdSense, Gmail, Google Transit, Google News, and Google Talk are the result of this 20 % program. My school is implementing the Next Generation Science Standards (NGSS) as part of our regularly scheduled curriculum review. These new standards focus on the process of learning by doing and designing. The NGSS are very hands on and active. The new standards emphasize learning how to define, understand and solve problems in science and technology. In today's society everyone needs to be familiar with science and technology. This project allows students to develop and practice skills to help them be more comfortable and confident with science and technology while exploring something of interest to them. This project includes three major parts: research, design, and presentation. Students will spend approximately 2-4 weeks defining a project proposal and educating themselves by researching a science and technology topic that is of interest to them. In the next phase, 2-4 weeks, students design a product or plan to collect data for something related to their topic. The time spent on research and design will be dependant on the topic students select. Projects should be ambitious enough to encompass about six weeks. Lastly a presentation or demonstration incorporating the research and design of the project is created, peer reviewed and presented to the class. There are some problems anticipated or already experienced with this project. It is difficult for all students to choose a unique topic when you have large class sizes

  10. The BioDynaMo Project: a platform for computer simulations of biological dynamics

    OpenAIRE

    Johard, Leonard; Breitwieser, Lukas; Di Meglio, Alberto; Manca, Marco; Mazzara, Manuel; Talanov, Max

    2016-01-01

    This paper is a brief update on developments in the BioDynaMo project, a new platform for computer simulations for biological research. We will discuss the new capabilities of the simulator, important new concepts simulation methodology as well as its numerous applications to the computational biology and nanoscience communities.

  11. Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project

    OpenAIRE

    Gil Amarilyo; Daniel E Furst; Woo, Jennifer M P; Wen Li; Henning Bliddal; Robin Christensen; Simon Tarp

    2016-01-01

    Background Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA) which independently analyzes the raw data and reports the results on its website. Objectives This study sought to determine if there are differences between the FDA assessments and journal reports on biologic agents developed for the treatment of rheumatoid arthritis. Methods Available data on FDA-approved drugs were extracted from the website, and a systematic literature search was conduc...

  12. Management of research and development project

    International Nuclear Information System (INIS)

    This book introduces summary on management of research and development project, prepare of research and development with investigation and analysis of paper, patent and trend of technology, structure of project, management model, management of project, management of project range, management of project time, management of project cost, management of project goods, management of project manpower, management of communication, management of project risk, management of project supply, management of outcome of R and D, management of apply and enroll of patent and management of technology transfer.

  13. Plant Biology and Biogeochemistry Department annual project report 1999

    DEFF Research Database (Denmark)

    Jensen, A.; Gissel Nielsen, G.; Giese, H.;

    2000-01-01

    The Department of Plant Biology and Biogeochemistry is engaged in basic and applied research to improve the scientific knowledge of developing new methods and technology for the future, environmentally benign industrial and agricultural production, thusexerting less stress and strain on the envir......The Department of Plant Biology and Biogeochemistry is engaged in basic and applied research to improve the scientific knowledge of developing new methods and technology for the future, environmentally benign industrial and agricultural production, thusexerting less stress and strain...... project summarizes and highlights our results and achievements to give an idea of the researchdirections in the Department. Some 160 persons, including staff, undergraduate students, postgraduate scientists and visiting scientists from all over the world, address our research goals. The Department......’s contribution to education and training ispresented. Lists of publications, papers accepted for publications, guest lecturers, exchange of scientists and lectures and poster presentations at meetings are included in the report. Names of the scientific, technical and administrative staff members...

  14. Experimental plasma research project summaries

    International Nuclear Information System (INIS)

    This is the latest in a series of Project Summary books going back to 1976 and is the first after a hiatus of several years. They are published to provide a short description of each project supported by the Experimental Plasma Research Branch of the Division of Applied Plasma Physics in the Office of Fusion Energy. The Experimental Plasma Research Branch seeks to provide a broad range of experimental data, physics understanding, and new experimental techniques that contribute to operation, interpretation, and improvement of high temperature plasma as a source of fusion energy. In pursuit of these objectives, the branch supports research at universities, DOE laboratories, other federal laboratories and industry. About 70 percent of the funds expended are spent at universities and a significant function of this program is the training of students in fusion physics. The branch supports small- and medium-scale experimental studies directly related to specific critical plasma issues of the magnetic fusion program. Plasma physics experiments are conducted on transport of particles and energy within plasma and innovative approaches for operating, controlling, and heating plasma are evaluated for application to the larger confinement devices of the magnetic fusion program. New diagnostic approaches to measuring the properties of high temperature plasmas are developed to the point where they can be applied with confidence on the large-scale confinement experiments. Atomic data necessary for impurity control, interpretation of diagnostic data, development of heating devices, and analysis of cooling by impurity ion radiation are obtained. The project summaries are grouped into these three categories of plasma physics, diagnostic development and atomic physics

  15. Current dichotomy between traditional molecular biological and omic research in cancer biology and pharmacology.

    Science.gov (United States)

    Reinhold, William C

    2015-12-10

    There is currently a split within the cancer research community between traditional molecular biological hypothesis-driven and the more recent "omic" forms or research. While the molecular biological approach employs the tried and true single alteration-single response formulations of experimentation, the omic employs broad-based assay or sample collection approaches that generate large volumes of data. How to integrate the benefits of these two approaches in an efficient and productive fashion remains an outstanding issue. Ideally, one would merge the understandability, exactness, simplicity, and testability of the molecular biological approach, with the larger amounts of data, simultaneous consideration of multiple alterations, consideration of genes both of known interest along with the novel, cross-sample comparisons among cell lines and patient samples, and consideration of directed questions while simultaneously gaining exposure to the novel provided by the omic approach. While at the current time integration of the two disciplines remains problematic, attempts to do so are ongoing, and will be necessary for the understanding of the large cell line screens including the Developmental Therapeutics Program's NCI-60, the Broad Institute's Cancer Cell Line Encyclopedia, and the Wellcome Trust Sanger Institute's Cancer Genome Project, as well as the the Cancer Genome Atlas clinical samples project. Going forward there is significant benefit to be had from the integration of the molecular biological and the omic forms or research, with the desired goal being improved translational understanding and application. PMID:26677427

  16. Race in Biological and Biomedical Research

    OpenAIRE

    Richard S Cooper

    2013-01-01

    The concept of race has had a significant influence on research in human biology since the early 19th century. But race was given its meaning and social impact in the political sphere and subsequently intervened in science as a foreign concept, not grounded in the dominant empiricism of modern biology. The uses of race in science were therefore often disruptive and controversial; at times, science had to be retrofitted to accommodate race, and science in turn was often used to explain and jus...

  17. Agreements and Discrepancies between FDA Reports and Journal Papers on Biologic Agents Approved for Rheumatoid Arthritis: A Meta-Research Project.

    Directory of Open Access Journals (Sweden)

    Gil Amarilyo

    Full Text Available Sponsors that seek to commercialize new drugs apply to the Food and Drug Administration (FDA which independently analyzes the raw data and reports the results on its website.This study sought to determine if there are differences between the FDA assessments and journal reports on biologic agents developed for the treatment of rheumatoid arthritis.Available data on FDA-approved drugs were extracted from the website, and a systematic literature search was conducted to identify matching studies in peer-reviewed medical journals. Outcome measures were the American College of Rheumatology response criteria ACR20 (efficacy and withdrawal due to adverse events (safety. As effect size odds ratios were estimated for each active trial arm vs. control arm (i.e. for both sources: FDA and journal report, followed by calculation of the ratios of the FDA and journal report odds ratios. A ratio of odds ratios not equal to 1 was categorized as a discrepancy.FDA reports were available for 8 of 9 FDA-approved biologic agents for rheumatoid arthritis; all identified trials (34 except one were published in peer-reviewed journals. Overall, discrepancies were noted for 20 of the 33 evaluated trials. Differences in the apparent benefit reporting were found in 39% (24/61 pairwise comparisons and in 11 cases these were statistically significant; the FDA report showed greater benefit than the journal publication in 15 comparisons and lesser benefit in 9. Differences in the reported harms were found in 51% (28/55 pairwise comparisons and were statistically significant in 5. The "signal" in FDA reports showed a less harmful effect than the journal publication in 17 comparisons whereas a more harmful effect in 11. The differences were attributed to differences in analytic approach, patient inclusion, rounding effect, and counting discrepancies. However, no differences were categorized as critical.There was no empirical evidence to suggest biased estimates between the two

  18. [Practice relevant research in biological psychiatry].

    Science.gov (United States)

    Meyer-Lindenberg, A

    2015-11-01

    The practice of psychiatry would be unthinkable without modern psychopharmacology. Drug treatment, especially of severe psychiatric disorders, is often a precondition of community participation, societal reintegration and recovery. Seen in this context it is understandable that biological psychiatry has long been primarily defined by its close interconnection with psychopharmacology and has been perceived this way by practicing physicians. In recent years, however, the concept of what is "biological" has markedly expanded and so has the outreach of this approach into the practice of psychiatry. This article discusses examples showing that biological research methods provide new impulses for individualized medicine, psychotherapy and understanding environmental risks and therefore provide the basis for a preemptive and preventive approach that will be the key to master the challenges posed by the severe burden of mental illness. PMID:26440519

  19. The Human Genome Project and Biology Education.

    Science.gov (United States)

    McInerney, Joseph D.

    1996-01-01

    Highlights the importance of the Human Genome Project in educating the public about genetics. Discusses four challenges that science educators must address: teaching for conceptual understanding, the nature of science, the personal and social impact of science and technology, and the principles of technology. Contains 45 references. (JRH)

  20. Adapting Project Management Practices to Research-Based Projects

    Science.gov (United States)

    Bahr, P.; Baker, T.; Corbin, B.; Keith, L.; Loerch, L.; Mullenax, C.; Myers, R.; Rhodes, B.; Skytland, N.

    2007-01-01

    From dealing with the inherent uncertainties in outcomes of scientific research to the lack of applicability of current NASA Procedural Requirements guidance documentation, research-based projects present challenges that require unique application of classical project management techniques. If additionally challenged by the creation of a new program transitioning from basic to applied research in a technical environment often unfamiliar with the cost and schedule constraints addressed by project management practices, such projects can find themselves struggling throughout their life cycles. Finally, supplying deliverables to a prime vehicle customer, also in the formative stage, adds further complexity to the development and management of research-based projects. The Biomedical Research and Countermeasures Projects Branch at NASA Johnson Space Center encompasses several diverse applied research-based or research-enabling projects within the newly-formed Human Research Program. This presentation will provide a brief overview of the organizational structure and environment in which these projects operate and how the projects coordinate to address and manage technical requirements. We will identify several of the challenges (cost, technical, schedule, and personnel) encountered by projects across the Branch, present case reports of actions taken and techniques implemented to deal with these challenges, and then close the session with an open forum discussion of remaining challenges and potential mitigations.

  1. Cancer systems biology: signal processing for cancer research

    Institute of Scientific and Technical Information of China (English)

    Olli Yli-Harja; Antti Ylip(a)(a); Matti Nykter; Wei Zhang

    2011-01-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  2. Cancer systems biology: signal processing for cancer research.

    Science.gov (United States)

    Yli-Harja, Olli; Ylipää, Antti; Nykter, Matti; Zhang, Wei

    2011-04-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts.

  3. Biological and chemical technologies research. FY 1995 annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-03-01

    The annual summary report presents the fiscal year (FY) 1995 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program. This BCTR program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1995 (ASR 95) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1995; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents; and awards arising from work supported by the BCTR.

  4. Getting Started With Research "Carrying Out Your Research Project"

    OpenAIRE

    Browne, Jacinta

    2014-01-01

    This paper gives an overview of the considerations and practical aspects of carrying out a research project which may be of use to those beginning their research career or simply carrying out a research project for the first time as part of an academic qualification. It outlines practical steps for consideration in the day to day management of a research project and highlights areas which require particular consideration for a project to be completed successfully.

  5. Interdisciplinary Biomathematics: Engaging Undergraduates in Research on the Fringe of Mathematical Biology

    Science.gov (United States)

    Fowler, Kathleen; Luttman, Aaron; Mondal, Sumona

    2013-01-01

    The US National Science Foundation's (NSF's) Undergraduate Biology and Mathematics (UBM) program significantly increased undergraduate research in the biomathematical sciences. We discuss three UBM-funded student research projects at Clarkson University that lie at the intersection of not just mathematics and biology, but also other…

  6. Onchocerciasis control: biological research is still needed

    Directory of Open Access Journals (Sweden)

    Boussinesq M.

    2008-09-01

    Full Text Available Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether onchocerciasis can be eliminated by ivermectin treatments, and the possible emergence of ivermectin-resistant O. volvulus populations should be addressed proactively. Doxycycline, moxidectin and emodepside appear to be promising as alternative drugs against onchocerciasis but support to researches in immunology and genomics should also be increased to develop new control tools, including both vaccines and macrofilaricidal drugs.

  7. Materials dispersion and biodynamics project research

    Science.gov (United States)

    Lewis, Marian L.

    1992-01-01

    The Materials Dispersion and Biodynamics Project (MDBP) focuses on dispersion and mixing of various biological materials and the dynamics of cell-to-cell communication and intracellular molecular trafficking in microgravity. Research activities encompass biomedical applications, basic cell biology, biotechnology (products from cells), protein crystal development, ecological life support systems (involving algae and bacteria), drug delivery (microencapsulation), biofilm deposition by living organisms, and hardware development to support living cells on Space Station Freedom (SSF). Project goals are to expand the existing microgravity science database through experiments on sounding rockets, the Shuttle, and COMET program orbiters and to evolve,through current database acquisition and feasibility testing, to more mature and larger-scale commercial operations on SSF. Maximized utilization of SSF for these science applications will mean that service companies will have a role in providing equipment for use by a number of different customers. An example of a potential forerunner of such a service for SSF is the Materials Dispersion Apparatus (MDA) 'mini lab' of Instrumentation Technology Associates, Inc. (ITA) in use on the Shuttle for the Commercial MDAITA Experiments (CMIX) Project. The MDA wells provide the capability for a number of investigators to perform mixing and bioprocessing experiments in space. In the area of human adaptation to microgravity, a significant database has been obtained over the past three decades. Some low-g effects are similar to Earth-based disorders (anemia, osteoporosis, neuromuscular diseases, and immune system disorders). As new information targets potential profit-making processes, services and products from microgravity, commercial space ventures are expected to expand accordingly. Cooperative CCDS research in the above mentioned areas is essential for maturing SSF biotechnology and to ensure U.S. leadership in space technology

  8. Biological effectiveness of neutrons: Research needs

    International Nuclear Information System (INIS)

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy

  9. Biological effectiveness of neutrons: Research needs

    Energy Technology Data Exchange (ETDEWEB)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  10. Computational systems biology for aging research.

    Science.gov (United States)

    Mc Auley, Mark T; Mooney, Kathleen M

    2015-01-01

    Computational modelling is a key component of systems biology and integrates with the other techniques discussed thus far in this book by utilizing a myriad of data that are being generated to quantitatively represent and simulate biological systems. This chapter will describe what computational modelling involves; the rationale for using it, and the appropriateness of modelling for investigating the aging process. How a model is assembled and the different theoretical frameworks that can be used to build a model are also discussed. In addition, the chapter will describe several models which demonstrate the effectiveness of each computational approach for investigating the constituents of a healthy aging trajectory. Specifically, a number of models will be showcased which focus on the complex age-related disorders associated with unhealthy aging. To conclude, we discuss the future applications of computational systems modelling to aging research.

  11. An O-"fish"-ial Research Project

    Science.gov (United States)

    Newman, James; Krustchinsky, Rick; Vanek, Karen; Nguyen, Kim-Thoa

    2009-01-01

    In this "O-"fish"-ial" research project, third-grade students use multiple resources to research several fish species, write a research paper and develop a PowerPoint presentation to communicate their findings. In addition, students actually examine these species up close with samples from the local market, and then conclude the project with a…

  12. Research Status and Prospect of Biological Manufacturing in China

    Institute of Scientific and Technical Information of China (English)

    Shuiying; LIU; Xinsheng; LI; Zhiyong; YANG; Hao; HAN

    2014-01-01

    The concept,research content and direction of biological manufacturing were elaborated in this text. The biological manufacturing progress in China,application situation,development trend and existing problems were analyzed,and the prospect of the development of biological manufacturing was put forward,in order to provide reference and guidance for the manufacture of biological research and industrial development.

  13. 2010 Plant Molecular Biology Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Michael Sussman

    2010-07-23

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.

  14. Biological and Environmental Research Network Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Balaji, V. [Princeton Univ., NJ (United States). Earth Science Grid Federation (ESGF); Boden, Tom [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cowley, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dart, Eli [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Dattoria, Vince [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Desai, Narayan [Argonne National Lab. (ANL), Argonne, IL (United States); Egan, Rob [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Foster, Ian [Argonne National Lab. (ANL), Argonne, IL (United States); Goldstone, Robin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gregurick, Susan [U.S. Dept. of Energy, Washington, DC (United States). Biological Systems Science Division; Houghton, John [U.S. Dept. of Energy, Washington, DC (United States). Biological and Environmental Research (BER) Program; Izaurralde, Cesar [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnston, Bill [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Joseph, Renu [U.S. Dept. of Energy, Washington, DC (United States). Climate and Environmental Sciences Division; Kleese-van Dam, Kerstin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lipton, Mary [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Monga, Inder [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Pritchard, Matt [British Atmospheric Data Centre (BADC), Oxon (United Kingdom); Rotman, Lauren [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Strand, Gary [National Center for Atmospheric Research (NCAR), Boulder, CO (United States); Stuart, Cory [Argonne National Lab. (ANL), Argonne, IL (United States); Tatusova, Tatiana [National Inst. of Health (NIH), Bethesda, MD (United States); Tierney, Brian [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Thomas, Brian [Univ. of California, Berkeley, CA (United States); Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zurawski, Jason [Internet2, Washington, DC (United States)

    2013-09-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet be a highly successful enabler of scientific discovery for over 25 years. In November 2012, ESnet and the Office of Biological and Environmental Research (BER) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the BER program office. Several key findings resulted from the review. Among them: 1) The scale of data sets available to science collaborations continues to increase exponentially. This has broad impact, both on the network and on the computational and storage systems connected to the network. 2) Many science collaborations require assistance to cope with the systems and network engineering challenges inherent in managing the rapid growth in data scale. 3) Several science domains operate distributed facilities that rely on high-performance networking for success. Key examples illustrated in this report include the Earth System Grid Federation (ESGF) and the Systems Biology Knowledgebase (KBase). This report expands on these points, and addresses others as well. The report contains a findings section as well as the text of the case studies discussed at the review.

  15. The Human Genome Project: Biology, Computers, and Privacy.

    Science.gov (United States)

    Cutter, Mary Ann G.; Drexler, Edward; Gottesman, Kay S.; Goulding, Philip G.; McCullough, Laurence B.; McInerney, Joseph D.; Micikas, Lynda B.; Mural, Richard J.; Murray, Jeffrey C.; Zola, John

    This module, for high school teachers, is the second of two modules about the Human Genome Project (HGP) produced by the Biological Sciences Curriculum Study (BSCS). The first section of this module provides background information for teachers about the structure and objectives of the HGP, aspects of the science and technology that underlie the…

  16. A Project-Based Biologically-Inspired Robotics Module

    Science.gov (United States)

    Crowder, R. M.; Zauner, K.-P.

    2013-01-01

    The design of any robotic system requires input from engineers from a variety of technical fields. This paper describes a project-based module, "Biologically-Inspired Robotics," that is offered to Electronics and Computer Science students at the University of Southampton, U.K. The overall objective of the module is for student groups to…

  17. Division of Biological and Medical Research annual research summary, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Barr, S.H. (ed.)

    1984-08-01

    This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology. (ACR)

  18. Division of Biological and Medical Research annual research summary, 1983

    International Nuclear Information System (INIS)

    This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology

  19. Summaries of research projects for fiscal years 1996 and 1997, medical applications and biophysical research

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-02-01

    The Medical Applications and Biophysical Research Division of the Office of Biological and Environmental Research supports and manages research in several distinct areas of science and technology. The projects described in this book are grouped by the main budgetary areas: General Life Sciences (structural molecular biology), Medical Applications (primarily nuclear medicine) and Measurement Science (analytical chemistry instrumentation), Environmental Management Science Program, and the Small Business Innovation Research Program. The research funded by this division complements that of the other two divisions in the Office of Biological and Environmental Research (OBER): Health Effects and Life Sciences Research, and Environmental Sciences. Most of the OBER programs are planned and administered jointly by the staff of two or all three of the divisions. This summary book provides information on research supported in these program areas during Fiscal Years 1996 and 1997.

  20. Advanced Energy Projects: FY 1993, Research summaries

    Energy Technology Data Exchange (ETDEWEB)

    1993-09-01

    AEP has been supporting research on novel materials for energy technology, renewable and biodegradable materials, new uses for scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, innovative approaches to waste treatment and reduction, etc. The summaries are grouped according to projects active in FY 1993, Phase I SBIR projects, and Phase II SBIR projects. Investigator and institutional indexes are included.

  1. Basic Project Management Methodologies for Survey Researchers.

    Science.gov (United States)

    Beach, Robert H.

    To be effective, project management requires a heavy dependence on the document, list, and computational capability of a computerized environment. Now that microcomputers are readily available, only the rediscovery of classic project management methodology is required for improved resource allocation in small research projects. This paper provides…

  2. Catalog of research projects at Lawrence Berkeley Laboratory, 1985

    International Nuclear Information System (INIS)

    This Catalog has been created to aid in the transfer of technology from the Lawrence Berkeley Laboratory to potential users in industry, government, universities, and the public. The projects are listed for the following LBL groups: Accelerator and Fusion Research Division, Applied Science Division, Biology and Medicine Division, Center for Advanced Materials, Chemical Biodynamics Division, Computing Division, Earth Sciences Division, Engineering and Technical Services Division, Materials and Molecular Research Division, Nuclear Science Division, and Physics Division

  3. Catalog of research projects at Lawrence Berkeley Laboratory, 1985

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This Catalog has been created to aid in the transfer of technology from the Lawrence Berkeley Laboratory to potential users in industry, government, universities, and the public. The projects are listed for the following LBL groups: Accelerator and Fusion Research Division, Applied Science Division, Biology and Medicine Division, Center for Advanced Materials, Chemical Biodynamics Division, Computing Division, Earth Sciences Division, Engineering and Technical Services Division, Materials and Molecular Research Division, Nuclear Science Division, and Physics Division.

  4. Engaging Biology Undergraduates in the Scientific Process through Writing a Theoretical Research Proposal

    Science.gov (United States)

    Stanford, Jennifer S.; Duwel, Laura E.

    2013-01-01

    It has been suggested that research experiences are an important element that should be included in all undergraduate Biology curricula. This is a difficult suggestion to accommodate due to issues with cost, space and time. We addressed this challenge through development of a capstone project in which Biology majors work in groups to develop novel…

  5. Modeling Research Project Risks with Fuzzy Maps

    Science.gov (United States)

    Bodea, Constanta Nicoleta; Dascalu, Mariana Iuliana

    2009-01-01

    The authors propose a risks evaluation model for research projects. The model is based on fuzzy inference. The knowledge base for fuzzy process is built with a causal and cognitive map of risks. The map was especially developed for research projects, taken into account their typical lifecycle. The model was applied to an e-testing research…

  6. Researching wicked problems in a construction project

    DEFF Research Database (Denmark)

    Jacobsen, Peter Holm

    Finding ones way through empirical research in a construction project can be a challenging affair. Reflections about the uncertainty that relates to the researchers work when he/she is collecting data and construction knowledge in empirical studies of construction projects, is an area that could ...

  7. Molecular biology approaches in bioadhesion research

    Directory of Open Access Journals (Sweden)

    Marcelo Rodrigues

    2014-07-01

    Full Text Available The use of molecular biology tools in the field of bioadhesion is still in its infancy. For new research groups who are considering taking a molecular approach, the techniques presented here are essential to unravelling the sequence of a gene, its expression and its biological function. Here we provide an outline for addressing adhesion-related genes in diverse organisms. We show how to gradually narrow down the number of candidate transcripts that are involved in adhesion by (1 generating a transcriptome and a differentially expressed cDNA list enriched for adhesion-related transcripts, (2 setting up a BLAST search facility, (3 perform an in situ hybridization screen, and (4 functional analyses of selected genes by using RNA interference knock-down. Furthermore, latest developments in genome-editing are presented as new tools to study gene function. By using this iterative multi-technologies approach, the identification, isolation, expression and function of adhesion-related genes can be studied in most organisms. These tools will improve our understanding of the diversity of molecules used for adhesion in different organisms and these findings will help to develop innovative bio-inspired adhesives.

  8. Biological data sciences in genome research.

    Science.gov (United States)

    Schatz, Michael C

    2015-10-01

    The last 20 years have been a remarkable era for biology and medicine. One of the most significant achievements has been the sequencing of the first human genomes, which has laid the foundation for profound insights into human genetics, the intricacies of regulation and development, and the forces of evolution. Incredibly, as we look into the future over the next 20 years, we see the very real potential for sequencing more than 1 billion genomes, bringing even deeper insight into human genetics as well as the genetics of millions of other species on the planet. Realizing this great potential for medicine and biology, though, will only be achieved through the integration and development of highly scalable computational and quantitative approaches that can keep pace with the rapid improvements to biotechnology. In this perspective, I aim to chart out these future technologies, anticipate the major themes of research, and call out the challenges ahead. One of the largest shifts will be in the training used to prepare the class of 2035 for their highly interdisciplinary world.

  9. Contribution to researches in biophysics and biology

    International Nuclear Information System (INIS)

    In this accreditation to supervise research, the author indicates its curriculum and scientific works which mainly dealt with the different agents used in chemotherapy. Scientific works addressed anti-carcinogenic pharmacology, applied biophysics, and researches in oncology and radiobiology. Current research projects deal with mechanisms of cellular transformation and the implication of the anti-oxidising metabolism and of nucleotide metabolism in cell radio-sensitivity. Teaching and research supervising activities are also indicated. Several articles are proposed in appendix: Average quality factor and dose equivalent meter based on microdosimetry techniques; Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns; Nucleotide metabolism in human gliomas, relation to the chromosomal profile; Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts; Modifications of the antioxidant metabolism during proliferation and differentiation of colon tumours cell lines; Modulation of the antioxidant enzymes, p21 and p53 expression during proliferation and differentiation of human melanoma cell lines; Purine metabolism in 2 human melanoma cell lines, relation with proliferation and differentiation; Radiation-induced changes in nucleotide metabolism of 2 colon cancer cell lines with different radio-sensitivities

  10. Advanced energy projects FY 1992 research summaries

    International Nuclear Information System (INIS)

    The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are beyond the scope of ongoing applied research or technology development programs. The Division provides a mechanism for converting basic research findings to applications that eventually could impact the Nation's energy economy. Technical topics include physical, chemical, materials, engineering, and biotechnologies. Projects can involve interdisciplinary approaches to solve energy-related problems. Projects are supported for a finite period of time, which is typically three years. Annual funding levels for projects are usually about $300,000 but can vary from approximately $50,000 to $500,000. It is expected that, following AEP support, each concept will be sufficiently developed and promising to attract further funding from other sources in order to realize its full potential. There were 39 research projects in the Division of Advanced Energy Projects during Fiscal Year 1992 (October 1, 1991 -- September 30, 1992). The abstracts of those projects are provided to introduce the overall program in Advanced Energy Projects. Further information on a specific project may be obtained by contacting the principal investigator, who is listed below the project title. Projects completed during FY 1992 are indicated

  11. Synthetic biology: An emerging research field in China

    OpenAIRE

    Pei, Lei; Schmidt, Markus; Wei, Wei

    2011-01-01

    Synthetic biology is considered as an emerging research field that will bring new opportunities to biotechnology. There is an expectation that synthetic biology will not only enhance knowledge in basic science, but will also have great potential for practical applications. Synthetic biology is still in an early developmental stage in China. We provide here a review of current Chinese research activities in synthetic biology and its different subfields, such as research on genetic circuits, mi...

  12. Has Modern Biology Entered the Mouth? The Clinical Impact of Biological Research.

    Science.gov (United States)

    Baum, Bruce J.

    1991-01-01

    Three areas of biological research that are beginning to have an impact on clinical medicine are examined, including molecular biology, cell biology, and biotechnology. It is concluded that oral biologists and educators must work cooperatively to bring rapid biological and biomedical advances into dental training in a meaningful way. (MSE)

  13. Division of Biological and Medical Research annual report 1978

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1978-01-01

    The research during 1978 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Studies related to nuclear energy include responses of beagles to continuous low-level /sup 60/Co gamma radiation, and development of leukemic indicators; comparison of lifetime effects in mice of low-level neutron and /sup 60/Co gamma radiation; genetic effects of high LET radiations; and metabolic and therapeutic studies of heavy metals. Studies of nonnuclear energy sources deal with characterization and toxicological evaluation of effluents of fluidized bed combustion and coal gasification; electrical storage systems; electric fields associated with energy transmission; and development of population projection models and assessment of human risk. Basic research studies include fundamental structural and biophysical investigations; circadian rhythms; mutagenesis in bacteria and mammalian cells; cell killing, damage, and repair in mammalian cells; carcinogenesis and cocarcinogenesis; the use of liposomes as biological carriers; and studies of environmental influences on life-span, physiological performance, and circadian cycles. In the area of medical development, proteins in urine and tissues of normal and diseased humans are analyzed, and advanced analytical procedures for use of stable isotopes in clinical research and diagnosis are developed and applied. The final sections of the report cover support facilities, educational activities, the seminar program, staff talks, and staff publications.

  14. Division of Biological and Medical Research annual report 1978

    International Nuclear Information System (INIS)

    The research during 1978 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Studies related to nuclear energy include responses of beagles to continuous low-level 60Co gamma radiation, and development of leukemic indicators; comparison of lifetime effects in mice of low-level neutron and 60Co gamma radiation; genetic effects of high LET radiations; and metabolic and therapeutic studies of heavy metals. Studies of nonnuclear energy sources deal with characterization and toxicological evaluation of effluents of fluidized bed combustion and coal gasification; electrical storage systems; electric fields associated with energy transmission; and development of population projection models and assessment of human risk. Basic research studies include fundamental structural and biophysical investigations; circadian rhythms; mutagenesis in bacteria and mammalian cells; cell killing, damage, and repair in mammalian cells; carcinogenesis and cocarcinogenesis; the use of liposomes as biological carriers; and studies of environmental influences on life-span, physiological performance, and circadian cycles. In the area of medical development, proteins in urine and tissues of normal and diseased humans are analyzed, and advanced analytical procedures for use of stable isotopes in clinical research and diagnosis are developed and applied. The final sections of the report cover support facilities, educational activities, the seminar program, staff talks, and staff publications

  15. Infusing Bioinformatics and Research-Like Experience into a Molecular Biology Laboratory Course

    Science.gov (United States)

    Nogaj, Luiza A.

    2014-01-01

    A nine-week laboratory project designed for a sophomore level molecular biology course is described. Small groups of students (3-4 per group) choose a tumor suppressor gene (TSG) or an oncogene for this project. Each group researches the role of their TSG/oncogene from primary literature articles and uses bioinformatics engines to find the gene…

  16. Research oriented projects on design themese

    DEFF Research Database (Denmark)

    Tollestrup, Christian; Eriksen, Kaare; Ovesen, Nis

    2011-01-01

    How can design students do research-oriented projects about design themes? At the 3rd semester at the Industrial Design Master Program at Aalborg University this is done by taking research oriented learning objectives on design theories and methods and combining them with experimental case studies...... with or without external parties like companies and consultancies. Programming the project is a large part of the 2½ month long project work and a “program” is handed in and evaluated after 3 weeks. During this programming the design students are going through a pre-reflection process, where they are designing...... the setup including the experiment or case that they will be carrying out. This approach shares characteristics of a regular research project, but the extent and level of complexity is much lower and the experiment and case is larger part of the project. At the other end of the project the analysis...

  17. Biological research for the radiation protection

    International Nuclear Information System (INIS)

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about polyamine effect on cell death triggered ionizing radiation, H2O2 and toxic agents. In this paper, to elucidate the role of polyamines as mediator in lysosomal damage and stress(H2O2)- induced apoptosis, we utilized α-DiFluoroMethylOrnithine (DFMO), which inhibited ornithine decarboxylase and depleted intracellular putrescine, and investigated the effects of polyamine on the apoptosis caused by H2O2, ionizing radiation and paraquat. We also showed that MGBG, inhibitor of polyamine biosynthesis, treatment affected intracellular redox steady states, intracellular ROS levels and protein oxidation. Thereafter we also investigated whether MGBG may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation or H2O2 because such compounds are able to potentiate the cell-killing effects. In addition, ceruloplasmin and thioredoxin, possible antioxidant proteins, were shown to have protective effect on radiation- or H2O2(or chemicals)-induced macromolecular damage or cell death

  18. pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students

    Science.gov (United States)

    Campbell, A. Malcolm; Eckdahl, Todd; Cronk, Brian; Andresen, Corinne; Frederick, Paul; Huckuntod, Samantha; Shinneman, Claire; Wacker, Annie; Yuan, Jason

    2014-01-01

    The "Vision and Change" report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area…

  19. Research projects of STUK 2000-2002

    International Nuclear Information System (INIS)

    The primary goal of STUK, the Finnish Radiation and Nuclear Safety Authority, is to prevent and limit the harmful effects of radiation. The research conducted by STUK yields new information related to the use, occurrence and effects of radiation. STUK research projects 2000 - 2002 summarises STUK's own research activities on radiation protection. In addition to these, STUK also supervises and funds research projects related to safety of nuclear energy and nuclear waste and materials that are carried out in other research institutes. Information on the research projects and related publications is also available on STUK's WWW pages at www.stuk.fi. STUK's research focuses on radiation protection and the health effects of radiation. During 2000 - 2002, the main emphasis will be on projects supporting the Finnish national environmental health action plan, the health risks of radiation, emergency preparedness and cooperation with neighbouring CEE areas. EU directives on radiation protection and medical exposure to radiation also influence the course taken by research carried out at STUK. New research priorities also include studies on non-ionising radiation, especially the effects of mobile phone frequency radiation. STUK's research activities are now more international than ever; the institute is involved in about 20 research projects funded by EC. Apart from the European Union and the Nordic countries, STUK's main partners are to be found in Russia, Estonia and the USA. (author)

  20. Research projects of STUK 2000-2002

    Energy Technology Data Exchange (ETDEWEB)

    Salomaa, S. [ed.

    2000-06-01

    The primary goal of STUK, the Finnish Radiation and Nuclear Safety Authority, is to prevent and limit the harmful effects of radiation. The research conducted by STUK yields new information related to the use, occurrence and effects of radiation. STUK research projects 2000 - 2002 summarises STUK's own research activities on radiation protection. In addition to these, STUK also supervises and funds research projects related to safety of nuclear energy and nuclear waste and materials that are carried out in other research institutes. Information on the research projects and related publications is also available on STUK's WWW pages at www.stuk.fi. STUK's research focuses on radiation protection and the health effects of radiation. During 2000 - 2002, the main emphasis will be on projects supporting the Finnish national environmental health action plan, the health risks of radiation, emergency preparedness and cooperation with neighbouring CEE areas. EU directives on radiation protection and medical exposure to radiation also influence the course taken by research carried out at STUK. New research priorities also include studies on non-ionising radiation, especially the effects of mobile phone frequency radiation. STUK's research activities are now more international than ever; the institute is involved in about 20 research projects funded by EC. Apart from the European Union and the Nordic countries, STUK's main partners are to be found in Russia, Estonia and the USA. (author)

  1. BCTR: Biological and Chemical Technologies Research 1994 annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.

    1995-02-01

    The annual summary report presents the fiscal year (FY) 1994 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). Although the OIT was reorganized in 1991 and AICD no longer exists, this document reports on efforts conducted under the former structure. The annual summary report for 1994 (ASR 94) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1994; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents, and awards arising from work supported by BCTR.

  2. Research program on the biological effects of oil pollution

    International Nuclear Information System (INIS)

    A national research program on the biological effects of oil pollution (FOBO) was initiated by the Norwegian Ministry of Environment in October 1983 in the light of the increasing oil exploration and production activity in the North Sea and northern Norwegian waters. Ambitions were high and five main fields of research were suggested: Seabirds, fish (incl. salmon), marine mammals, the littoral zone and plankton. However, due to the lack of interest on the part of other potential financers, e.g. the Ministry of Fisheries and the oil companies, to participate, the four-year programme had to be limited to the following three topics: Seabirds around bruding colonies and at sea; Higher plants along the shoreline; The littoral zone. The program ran from the autumn of 1985 to the end of 1989 and this report summarizes the main results and conclusions of each project. 95 refs., 52 figs., 9 tabs

  3. Advanced energy projects FY 1997 research summaries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    The mission of the Advanced Energy Projects (AEP) program is to explore the scientific feasibility of novel energy-related concepts that are high risk, in terms of scientific feasibility, yet have a realistic potential for a high technological payoff. The concepts supported by the AEP are typically at an early stage of scientific development. They often arise from advances in basic research and are premature for consideration by applied research or technology development programs. Some are based on discoveries of new scientific phenomena or involve exploratory ideas that span multiple scientific and technical disciplines which do not fit into an existing DOE program area. In all cases, the objective is to support evaluation of the scientific or technical feasibility of the novel concepts involved. Following AEP support, it is expected that each concept will be sufficiently developed to attract further funding from other sources to realize its full potential. Projects that involve evolutionary research or technology development and demonstration are not supported by AEP. Furthermore, research projects more appropriate for another existing DOE research program are not encouraged. There were 65 projects in the AEP research portfolio during Fiscal Year 1997. Eigheen projects were initiated during that fiscal year. This document consists of short summaries of projects active in FY 1997. Further information of a specific project may be obtained by contacting the principal investigator.

  4. Plant biology research and training for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, K. [ed.

    1992-12-31

    The committee was assembled in response to a request from the National Science Foundation (NSF), the US Department of Agriculture (USDA), and the US Department of Energy (DoE). The leadership of these agencies asked the National Academy of Sciences through the National Research Council (NRC) to assess the status of plant-science research in the United States in light of the opportunities arising from advances inother areas of biology. NRC was asked to suggest ways of accelerating the application of these new biologic concepts and tools to research in plant science with the aim of enhancing the acquisition of new knowledge about plants. The charge to the committee was to examine the following: Organizations, departments, and institutions conducting plant biology research; human resources involved in plant biology research; graduate training programs in plant biology; federal, state, and private sources of support for plant-biology research; the role of industry in conducting and supporting plant-biology research; the international status of US plant-biology research; and the relationship of plant biology to leading-edge research in biology.

  5. Plant biology research and training for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, K. (ed.)

    1992-01-01

    The committee was assembled in response to a request from the National Science Foundation (NSF), the US Department of Agriculture (USDA), and the US Department of Energy (DoE). The leadership of these agencies asked the National Academy of Sciences through the National Research Council (NRC) to assess the status of plant-science research in the United States in light of the opportunities arising from advances inother areas of biology. NRC was asked to suggest ways of accelerating the application of these new biologic concepts and tools to research in plant science with the aim of enhancing the acquisition of new knowledge about plants. The charge to the committee was to examine the following: Organizations, departments, and institutions conducting plant biology research; human resources involved in plant biology research; graduate training programs in plant biology; federal, state, and private sources of support for plant-biology research; the role of industry in conducting and supporting plant-biology research; the international status of US plant-biology research; and the relationship of plant biology to leading-edge research in biology.

  6. Large Scale Research Project, Daidalos Evaluation Framework

    OpenAIRE

    Cleary, Frances; Ponce de Leon, Miguel; GARCÍA MORENO, Marta; ROMERO VICENTE, Antonio; Roddy, Mark

    2007-01-01

    For large scale research projects operational over a phased timeframe of 2 years or more, the need to take a step back and evaluate their stance and direction is an important activity in providing relevant feedback and recommendations to guide the project towards success in its consecutive phase. The identification of measurable goals and evaluation profile procedures to effectively work towards a useful evaluation of the project was one of the main aims of the Evaluation taskforce. As part o...

  7. Advanced energy projects: FY 1987 research summaries

    International Nuclear Information System (INIS)

    This report contains brief summaries of all projects active in the Division of Advanced Energy Projects during Fiscal Year 1987 (October 1, 1986-September 30, 1987). The intent of this compilation is to provide a convenient means for quickly acquainting an interested reader with the program in Advanced Energy Projects. More detailed information on research activities in a particular project may be obtained by contacting directly the principal investigator. Some projects will have reached the end of their contract periods by the time this book appears, and will, therefore, no longer be active. Those cases in which work was completed in FY '87 are indicated by the footnote: Project completed. The annual funding level of each project is shown

  8. Leading Edge Aeronautics Research for NASA Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The LEARN Project explores the creation of novel concepts and processes with the potential to create new capabilities in aeronautics research through awards to the...

  9. STUK research projects 1998-2000

    International Nuclear Information System (INIS)

    The primary goal of STUK, the Finnish Radiation and Nuclear Safety Authority, is to prevent and limit the harmful effects of radiation. The research conducted by STUK yields new information related to the use, occurrence and effects of radiation and promotes the supervision of nuclear safety. STUK research projects 1998 - 2000 summarizes STUK's own research projects and commissioned research designed to promote the supervision of nuclear safety. Information on the research projects and related publications is also available on STUK's WWW pages at www.stuk.fi. The work done on the safe use of nuclear power and nuclear waste management mainly comprises commissioned research projects which derive from the needs of authorities, and are funded and directed by STUK. This research is conducted by organizations outside STUK, but supervised by STUK experts. In some cases, STUK personnel are also involved. The goal of this research work is to produce the information needed for decision-making, to develop supervisory methods and to ensure that recent developments in science and technology are taken into account in action to promote safe use of nuclear power. STUK's own research focuses on radiation protection and the health effects of radiation. During 1998 - 2000, the main emphasis will be on projects supporting the Finnish national environmental health action plan, the health risks of radiation, emergency preparedness and cooperation with neighbouring CEE areas. EU directives on radiation protection and medical exposure to radiation also influence the course taken by research carried out at STUK. STUK's research activities are now more international than ever; the institute is involved in more then 20 research projects funded by EU. Apart from the EU and the Nordic countries, STUK's main partners are to be found in Russia, Estonia and the USA. (orig.)

  10. Translational Research: From Biological Discovery to Public Benefit (or Not

    Directory of Open Access Journals (Sweden)

    Michael R. Emmert-Buck

    2014-01-01

    Full Text Available Advances in biology are occurring at a breathtaking pace today, from genetic insights facilitated by the Human Genome Project and next generation DNA sequencing technologies, to global nucleic acid and proteomic expression measurement using new high-throughput methods. Less publicized in recent years, yet still the central driver of progress, are the steadily proceeding biological insights gained through tried and true hypothesis-driven investigation into the complex worlds of metabolism, growth, development, and regulation. Certainly, the basic science ecosystem is productive and this portends well for the myriad new applications that will benefit mankind; drugs, vaccines, devices, and related economic growth—or perhaps not—in stark contrast to the generation of fundamental biological knowledge are inefficiencies in applying this information to real-world problems, especially those of the clinic. While investigation hums along at light speed, translation often does not. The good news is that obstacles to progress are tractable. The bad news, however, is that these problems are difficult. The present paper examines translational research from multiple perspectives, beginning with a historical account and proceeding to the current state of the art. Included are descriptions of successes and challenges, along with conjecture on how the field may need to evolve in the future.

  11. Structural biology computing: Lessons for the biomedical research sciences.

    Science.gov (United States)

    Morin, Andrew; Sliz, Piotr

    2013-11-01

    The field of structural biology, whose aim is to elucidate the molecular and atomic structures of biological macromolecules, has long been at the forefront of biomedical sciences in adopting and developing computational research methods. Operating at the intersection between biophysics, biochemistry, and molecular biology, structural biology's growth into a foundational framework on which many concepts and findings of molecular biology are interpreted1 has depended largely on parallel advancements in computational tools and techniques. Without these computing advances, modern structural biology would likely have remained an exclusive pursuit practiced by few, and not become the widely practiced, foundational field it is today. As other areas of biomedical research increasingly embrace research computing techniques, the successes, failures and lessons of structural biology computing can serve as a useful guide to progress in other biomedically related research fields.

  12. HUMAN RESOURCES MANAGEMENT STRATEGYADDRESSED IN RESEARCH PROJECTS

    OpenAIRE

    Ecaterina Gicã; Nicoleta Dumitrache

    2011-01-01

    Research entities can achieve sustainable competitive advantages, exercised by strategic operational management of their human resources. But conditions are still unclear: how employees of an eligible research entity can benefit from a strategic human resource management (SHRM) so that they make performances in research - development and innovation, knowing that this area is one with its own status. An important role in the success of national and international research projects plays the hum...

  13. Scientific projection paper for space radiobiological research

    International Nuclear Information System (INIS)

    A nationale for the radiobiological research requirements for space is rooted in a national commitment to the exploration of space, mandated in the form of the National Space Act. This research is almost entirely centered on man; more specifically, on the effects of the space radiation environment on man and his protection from them. The research needs discussed in this presentation include the space radiation environment; dosimetry; radiation biology-high LET particles (dose/response); and operational countermeasures

  14. Cultural differences in Research project management

    Science.gov (United States)

    Barbier, Michele

    2016-04-01

    Scientific Projects today have increased in complexity, requiring multidisciplinarity, and requiring a mix of diverse individuals from different countries who must be integrated into an effective project. Effective team building is one of the prime responsibilities of the project manager. When the project is supported by a funding, the integration and the implication of the different partners are quite easy. Particularly when partners are developing high-performing teams. However, management of research project requires further skills when the budget is not very high and/or when partners are from non-European countries and are not using the same vocabulary. The various cultures, values, beliefs and social usages, particularly with Mediterranean countries cause a special style of communication for an individual or group of individuals. This communication style participates in the success of the project and encompasses a lot of diplomatic skills which will be highlighted.

  15. Annual review of research projects 1983

    International Nuclear Information System (INIS)

    This progress report provides a brief outline of current laboratory research and development projects and their present status. Research fields covered are: uranium, radon and its daughters, radiation effects in solids and gases, thermoluminescence, x-rays and clinical dosimetry, measurement standards in radiation dosimetry, radiopharmaceuticals and nuclear medicine, radionuclide metrology, non-ionizing electromagnetic radiations, environmental radiochemistry and radiation monitoring

  16. Jmol-Enhanced Biochemistry Research Projects

    Science.gov (United States)

    Saderholm, Matthew; Reynolds, Anthony

    2011-01-01

    We developed a protein research project for a one-semester biochemistry lecture class to enhance learning and more effectively train students to understand protein structure and function. During this semester-long process, students select a protein with known structure and then research its structure, sequence, and function. This project…

  17. Annual review of research projects 1984

    International Nuclear Information System (INIS)

    This progress report provides a brief outline of current laboratory research and development projects and their present status. Research fields covered are: uranium, radon and its daughters, radiation effects in solids and gases, x-rays and clinical dosimetry, measurement standards in radiation dosimetry, radiopharmaceuticals and nuclear medicine, non-ionizing electromagnetic radiations, environmental radiochemistry and radiation monitoring

  18. U1/U2 crib groundwater biological treatment demonstration project

    International Nuclear Information System (INIS)

    The primary objective of the biological treatment project is to develop and demonstrate a process for Hanford groundwater remediation. Biodenitrification using facultative anaerobic microorganisms is a promising technology for the simultaneous removal of nitrates and organics from contaminated aqueous streams. During FY 1988, a consortium of Hanford groundwater microorganisms was shown to degrade both nitrates and carbon tetrachloride (CC14). A pilot-scale treatment system was designed and constructed based on the results of laboratory-and-bench-scale testing. This report summarizes the results of biological groundwater treatment studies performed during FY 1989 at the pilot-scale. These tests were conducted using a simulated Hanford groundwater with a continuous stirred-tank bioreactor, and a fluidized-bed bioreactor that was added to the pilot-scale treatment system in FY 1989. The pilot-scale system demonstrated continuous degradation of nitrates and CC14 in a simulated groundwater. 4 refs., 7 figs., 1 tab

  19. Methodology of impact assessment of research projects

    International Nuclear Information System (INIS)

    In the context of the management of research projects development it is necessary to have tools to monitor and evaluate progress and the performance of the projects, as well as their results and the impact on society (international agencies of the United Nations and the States 2002 and 2005 Paris Declaration), with the objective of to ensure their contribution to the social and economic development of countries. Many organizations, agencies and Governments apply different methodologies (IDB, World Bank, UNDP, ECLAC, UNESCO; UNICEF, Canada, Japan, other) for these purposes. In the results-based project management system not only paramount is the process or product itself, but also the result or impact of the project (if the program/project produced the effects desired persons, households and institutions and whether those effects are attributable to the intervention of the program / project). The work shows a methodology that allows for a qualitative and quantitative evaluation of impact of research projects and has been result of experience in project management of international collaboration with the International Agency for Atomic Energy (IAEA) and the Cuban Nuclear programme. (author)

  20. Meta-Research: Broadening the Scope of PLOS Biology.

    Science.gov (United States)

    Kousta, Stavroula; Ferguson, Christine; Ganley, Emma

    2016-01-01

    In growing recognition of the importance of how scientific research is designed, performed, communicated, and evaluated, PLOS Biology announces a broadening of its scope to cover meta-research articles.

  1. Light water reactor safety research project

    International Nuclear Information System (INIS)

    The research and development activities for the safety of Light Water Power Reactors carried out 1979 at the Swiss Federal Institute for Reactor Research are described. Considerations concerning the necessity, objectives and size of the Safety Research Project are presented, followed by a detailed discussion of the activities in the five tasks of the program, covering fracture mechanics and nondestructive testing, thermal-hydraulics, reactor noise analysis and pressure vessel steel surveillance. (Auth.)

  2. Nuclear safety research project. Annual report 1995

    International Nuclear Information System (INIS)

    The reactor safety R and D work of the Karlsruhe Research Centre (FZK) has been part of the Nuclear Safety Research Project (PSF) since 1990. The present annual report 1995 summarizes the R and D results. The research tasks are coordinated in agreement with internal and external working groups. The contributions to this report correspond to the status of early 1996. An abstract in English precedes each of them, whenever the respective article is written in German. (orig.)

  3. Commentary: Systems Biology and Its Relevance to Alcohol Research

    OpenAIRE

    Guo, Q. Max; Zakhari, Sam

    2008-01-01

    Systems biology, a new scientific discipline, aims to study the behavior of a biological organization or process in order to understand the function of a dynamic system. This commentary will put into perspective topics discussed in this issue of Alcohol Research & Health, provide insight into why alcohol-induced disorders exemplify the kinds of conditions for which a systems biological approach would be fruitful, and discuss the opportunities and challenges facing alcohol researchers.

  4. [Analogies and analogy research in technical biology and bionics].

    Science.gov (United States)

    Nachtigall, Werner

    2010-01-01

    The procedural approaches of Technical Biology and Bionics are characterized, and analogy research is identified as their common basis. The actual creative aspect in bionical research lies in recognizing and exploiting technically oriented analogies underlying a specific biological prototype to indicate a specific technical application.

  5. Summaries of fiscal year 1994 projects in medical applications and biophysical research

    International Nuclear Information System (INIS)

    This report provides information on the research supported in Fiscal Year 1994 by the Medical Applications and Biophysical Research Division of the Office of Health and Environmental Research. A brief statement of the scope of the following areas is presented: dosimetry; measurement science; radiological and chemical physics; structural biology; human genome; and medical applications. Summaries of the research projects in these categories are presented

  6. Are Project Developers Knights and Researchers Queens?

    DEFF Research Database (Denmark)

    Vinstrup, Anya Bjørn

    2014-01-01

    How do project developers at universities view their customers – the researchers, and how do they see themselves as a profession? Does this view influence their motivation and what challenges does it impose? Taking elements of theory from Public Service Motivation (PSM) and linking it with a small...... empirically based survey among the project developers at a centrally located office at a university in Denmark – these questions are sought to be answered. The focal point being the motivation of the project developer, with special emphasis on their user perception, and the practical implications it has...

  7. Advanced energy projects FY 1994 research summaries

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are premature for consideration by applied research or technology development programs. The AEP also supports high-risk, exploratory concepts that do not readily fit into a program area but could have several applications that may span scientific disciplines or technical areas. Projects supported by the Division arise from unsolicited ideas and concepts submitted by researchers. The portfolio of projects is dynamic and reflects the broad role of the Department in supporting research and development for improving the Nation`s energy outlook. FY 1994 projects include the following topical areas: novel materials for energy technology; renewable and biodegradable materials; exploring uses of new scientific discoveries; alternate pathways to energy efficiency; alternative energy sources; and innovative approaches to waste treatment and reduction. Summaries are given for 66 projects.

  8. Advanced energy projects FY 1994 research summaries

    International Nuclear Information System (INIS)

    The Division of Advanced Energy Projects (AEP) provides support to explore the feasibility of novel, energy-related concepts that evolve from advances in basic research. These concepts are typically at an early stage of scientific definition and, therefore, are premature for consideration by applied research or technology development programs. The AEP also supports high-risk, exploratory concepts that do not readily fit into a program area but could have several applications that may span scientific disciplines or technical areas. Projects supported by the Division arise from unsolicited ideas and concepts submitted by researchers. The portfolio of projects is dynamic and reflects the broad role of the Department in supporting research and development for improving the Nation's energy outlook. FY 1994 projects include the following topical areas: novel materials for energy technology; renewable and biodegradable materials; exploring uses of new scientific discoveries; alternate pathways to energy efficiency; alternative energy sources; and innovative approaches to waste treatment and reduction. Summaries are given for 66 projects

  9. Advanced energy projects; FY 1995 research summaries

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    The AEP Division supports projects to explore novel energy-related concepts which are typically at an early stage of scientific development, and high-risk, exploratory concepts. Topical areas presently receiving support are: novel materials for energy technology, renewable and biodegradable materials, exploring uses of new scientific discoveries, alternate pathways to energy efficiency, alternative energy sources, and innovative approaches to waste treatment and reduction. There were 46 research projects during FY 1995; ten were initiated during that fiscal year. The summaries are separated into grant and laboratory programs, and small business innovation research programs.

  10. Research reactor job analysis - A project description

    International Nuclear Information System (INIS)

    Addressing the need of the improved training in nuclear industry, nuclear utilities established training program guidelines based on Performance-Based Training (PBT) concepts. The comparison of commercial nuclear power facilities with research and test reactors owned by the U.S. Department of Energy (DOE), made in an independent review of personnel selection, training, and qualification requirements for DOE-owned reactors pointed out that the complexity of the most critical tasks in research reactors is less than that in power reactors. The U.S. Department of Energy (DOE) started a project by commissioning Oak Ridge Associated Universities (ORAU) to conduct a job analysis survey of representative research reactor facilities. The output of the project consists of two publications: Volume 1 - Research Reactor Job Analysis: Overview, which contains an Introduction, Project Description, Project Methodology,, and. An Overview of Performance-Based Training (PBT); and Volume 2 - Research Reactor Job Analysis: Implementation, which contains Guidelines for Application of Preliminary Task Lists and Preliminary Task Lists for Reactor Operators and Supervisory Reactor Operators

  11. openBIS: a flexible framework for managing and analyzing complex data in biology research

    OpenAIRE

    Bauch Angela; Adamczyk Izabela; Buczek Piotr; Elmer Franz-Josef; Enimanev Kaloyan; Glyzewski Pawel; Kohler Manuel; Pylak Tomasz; Quandt Andreas; Ramakrishnan Chandrasekhar; Beisel Christian; Malmström Lars; Aebersold Ruedi; Rinn Bernd

    2011-01-01

    Abstract Background Modern data generation techniques used in distributed systems biology research projects often create datasets of enormous size and diversity. We argue that in order to overcome the challenge of managing those large quantitative datasets and maximise the biological information extracted from them, a sound information system is required. Ease of integration with data analysis pipelines and other computational tools is a key requirement for it. Results We have developed openB...

  12. Current research in Radiation Biology and Biochemistry Division

    International Nuclear Information System (INIS)

    The Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay has been engaged in research in the frontier areas of (i) radiation biology related to tumour therapy and injury caused by free radicals; (ii) molecular basis of diseases of physiological origin; (iii) molecular aspects of chemical carcinogenesis and (iv) structure of genome and genome related functions. The gist of research and development activities carried out in the Division during the last two years are documented

  13. Projecting the Future for Design Science Research

    DEFF Research Database (Denmark)

    Baskerville, Richard; Pries-Heje, Jan

    2015-01-01

    Design science research should be relevant, valuable, purposeful and prescriptive. Its value as a relevant source of prescriptions implies the practical usefulness of its results beyond a single expository instantiation. But propagation of such design science products as design principles....... In this paper we discuss the propagation issues around generalizing design science research across multiple contexts and propose alternative propagation concepts of projectability and entrenchment. The existing concepts around generalizability have issues that make them less suitable for design science research...... or theories have stimulated many actual projections. We demonstrate these concepts in a case study of propagation: a chemical manufacturer and service provider that adopted the design principles arising from that 2012 DESRIST banking-based design science research. We conclude that generalizability is too well...

  14. New projections of clinical research in Ecuador

    Directory of Open Access Journals (Sweden)

    Thelvia I. Ramos

    2016-01-01

    Full Text Available The accelerated development of the pharmaceutical industry, particularly the industry of biologics products, has brought an increase in clinical research and strengthening regulatory agencies to achieve product registration studies in the shortest time and with the required quality under the rules of Good Clinical Practice. For improvement of this type of research arise Contract Research Organizations (CRO, which allow the development of research and provide services ranging from preclinical studies to conducting and realization of clinical trials. For instance, these companies should know the peculiarities of the product and, to demonstrate safety, efficacy and entrance to pharmaceutical market with a precise indication. In this article we hereby inform you the first CRO in Ecuador to meet these standards for clinical research.

  15. Evaluation of combustion experiments conducted during the research and development project ``Mechanical-biological waste conditioning in combination with thermal processing of partial waste fractions``; Auswertung der Verbrennungsversuche zum Forschungs- und Entwicklungsvorhaben ``mechanisch-biologische Restmuellbehandlung unter Einbindung thermischer Verfahren fuer Teilfraktionen``

    Energy Technology Data Exchange (ETDEWEB)

    Jager, J.; Lohf, A.; Herr, C. [Institut WAR, Darmstadt (Germany)

    1998-12-31

    The technical code on municipal waste makes specific demands on waste to be deposited at landfills which can only be met if mechanical-biological conditioning of waste as well as thermal processing of partial waste fractions are continued also in the future. But waste that has undergone mechanical or mechanical-biological conditioning presents different combustion properties from those of unconditioned waste. In this second stage of the research project, the thermal processability of waste having undergone mechanical or mechanical-biological conditioning was studied. Together with the results from the first project stage, where the throughput represented exclusively mechanically conditioned material, the results of the latter measuring campaigns comprehensively demonstrate possibilities for the thermal processing of partial waste fractions having undergone biological-mechanical conditioning, and inform on changes in plant performance. (orig.) [Deutsch] Um die in der TA-Siedlungsabfall an den abzulagernden Restmuell gestellten Deponieeingangsbedingungen zu erfuellen, muss neben einer mechanisch-biologischen Aufbereitung bei Teilfraktionen auch weiterhin eine thermische Behandlung eingeplant werden. Die Verbrennungseigenschaften von mechanisch oder mechanisch-biologisch vorbehandeltem Restmuell weichen allerdings von denen von unbehandeltem Restmuell ab. In dieser zweiten Projektphase des Forschungsvorhabens wurde eine Untersuchung bezueglich der thermischen Behandelbarkeit von mechanisch und auch biologisch vorbehandeltem Muell durchgefuehrt. Die Ergebnisse der Messkampagnen bilden zusammen mit den Ergebnissen der ersten Projektphase, in der ausschliesslich mechanisch vorbehandeltes Material durchgesetzt wurde, eine umfassende Darstellung ueber Moeglichkeiten und veraenderte Anlagenverhalten bei der thermischen Behandlung von Teilfraktionen aus der biologisch-mechanisch Vorbehandlung. (orig.)

  16. A multicriteria method for evaluating transport research projects.

    OpenAIRE

    La Paix Puello, Lissy Cesarina; López Lambas, Maria Eugenia

    2010-01-01

    Research evaluation has emerged as a ―rapid growth industry‖. Every four years more than 10 billion Euros are allocated to research projects by the European Commission through Framework Programmes. During the last ten years a large number of research projects have been addressed to evaluate other projects. However, some evaluation projects do not take a global view of the project results. The evaluation of research projects in the field of transport should be ‗quantified‘ as follows: R...

  17. Stable isotopes: essential tools in biological and medical research

    Energy Technology Data Exchange (ETDEWEB)

    Klein, P. D.; Hachey, D. L.; Kreek, M. J.; Schoeller, D. A.

    1977-01-01

    Recent developments in the use of the stable isotopes, /sup 13/C, /sup 15/N, /sup 17/O, and /sup 18/O, as tracers in research studies in the fields of biology, medicine, pharmacology, and agriculture are briefly reviewed. (CH)

  18. Biological Research in Canisters (BRIC) - Light Emitting Diode (LED)

    Science.gov (United States)

    Levine, Howard G.; Caron, Allison

    2016-01-01

    The Biological Research in Canisters - LED (BRIC-LED) is a biological research system that is being designed to complement the capabilities of the existing BRIC-Petri Dish Fixation Unit (PDFU) for the Space Life and Physical Sciences (SLPS) Program. A diverse range of organisms can be supported, including plant seedlings, callus cultures, Caenorhabditis elegans, microbes, and others. In the event of a launch scrub, the entire assembly can be replaced with an identical back-up unit containing freshly loaded specimens.

  19. Synthesis on biological soil crust research

    Science.gov (United States)

    Weber, Bettina; Belnap, Jayne; Buedel, Burkhard

    2016-01-01

    In this closing chapter, we summarize the advances in biocrust research made during the last 1.5 decades. In the first part of the chapter, we discuss how in some research fields, such as the microbial diversity of fungi, bacteria, and microfauna; the interaction between biocrusts and vascular plants; and in the rehabilitation of biocrusts; particularly large achievements have been made. In other fields, previously established knowledge of overall patterns has been corroborated and refined by additional studies, e.g., in the fields of soil stabilization and disturbance effects. In the second part of the chapter, we outline the research gaps and challenges foreseen by us. We identify multiple knowledge gaps, including many understudied geographic regions, the largely missing link between genetic and morphological species identification data, and the answers to some mechanistic questions, such as the overall role of biocrusts in hydrology and nutrient cycles. With some ideas on promising new research questions and approaches we close this chapter and the overall book.

  20. Project for a renewable energy research centre

    Directory of Open Access Journals (Sweden)

    Andrea Giachetta

    2011-04-01

    Full Text Available In Liguria, where sustainable approaches to the design, construction and management of buildings enjoy scant currency, the idea of a company from Milan (FERA s.r.l. setting up a research centre for studies into renewable energy resources, could well open up very interesting development opportunities.The project includes: environmental rehabilitation (restoration projects; strategies for the protection of water resources and waste management systems; passive and active solar systems (solar thermal and experiments with thermodynamic solar energy; hyperinsulation systems, passive cooling of buildings; use of natural materials; bio-climatic use of vegetation. The author describes the project content within the context of the multidisciplinary work that has gone into it.

  1. openBIS: a flexible framework for managing and analyzing complex data in biology research

    Directory of Open Access Journals (Sweden)

    Bauch Angela

    2011-12-01

    Full Text Available Abstract Background Modern data generation techniques used in distributed systems biology research projects often create datasets of enormous size and diversity. We argue that in order to overcome the challenge of managing those large quantitative datasets and maximise the biological information extracted from them, a sound information system is required. Ease of integration with data analysis pipelines and other computational tools is a key requirement for it. Results We have developed openBIS, an open source software framework for constructing user-friendly, scalable and powerful information systems for data and metadata acquired in biological experiments. openBIS enables users to collect, integrate, share, publish data and to connect to data processing pipelines. This framework can be extended and has been customized for different data types acquired by a range of technologies. Conclusions openBIS is currently being used by several SystemsX.ch and EU projects applying mass spectrometric measurements of metabolites and proteins, High Content Screening, or Next Generation Sequencing technologies. The attributes that make it interesting to a large research community involved in systems biology projects include versatility, simplicity in deployment, scalability to very large data, flexibility to handle any biological data type and extensibility to the needs of any research domain.

  2. Research on Chinese Visible Human Project

    Institute of Scientific and Technical Information of China (English)

    ZhangShaoxiang

    2003-01-01

    “Visible Human Project (VHP)” was initiated by US National Library of Medicine in 1989, and in August 1991, the library signed a contract with Health Science Center of the University of Col-orado to formally carry out the project. According-ly, research team at the University of Colorado col-lected a structural data set of human body after obtaining successive sectiona/ images. A digital image data set of a complete human male cadaver was acquired and made available for public use in November 1994, which aroused worldwide enthu-siasm in this field, and remarkable social and eco-nomic benefit has been gained. Thereafter, some countries initiated their visible human project one after another. Korea started 5-year“Visible Kore-an Human (VKH)” project (Mar. 2000--Feb.2005) in 2000, and the first data set derived from apatient with cerebroma was acquired in 2001. Chi-na began its project in 1999. The first data set of Chinese visible human was obtained at The Third Military Medical University in October 2002. Before that, by utilizing data made public by US VHP, Chi-nese scientists in informatics had exerted them-selves on preliminary work to pave the way for fur-ther achievement. Now that VHP research is such a promising scientific field to meet the need of digital era and will be increasingly common in many areas related with structure and function of human body,the deployment of Chinese Visible Human Project(CVHP) is of great strategic significance with re-gard to science and technology.

  3. The Systems Biology Research Tool: evolvable open-source software

    Directory of Open Access Journals (Sweden)

    Wright Jeremiah

    2008-06-01

    Full Text Available Abstract Background Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level. Results We introduce a free, easy-to-use, open-source, integrated software platform called the Systems Biology Research Tool (SBRT to facilitate the computational aspects of systems biology. The SBRT currently performs 35 methods for analyzing stoichiometric networks and 16 methods from fields such as graph theory, geometry, algebra, and combinatorics. New computational techniques can be added to the SBRT via process plug-ins, providing a high degree of evolvability and a unifying framework for software development in systems biology. Conclusion The Systems Biology Research Tool represents a technological advance for systems biology. This software can be used to make sophisticated computational techniques accessible to everyone (including those with no programming ability, to facilitate cooperation among researchers, and to expedite progress in the field of systems biology.

  4. Researchers' experience with project management in health and medical research: Results from a post-project review

    Directory of Open Access Journals (Sweden)

    Elliott Elizabeth J

    2011-06-01

    Full Text Available Abstract Background Project management is widely used to deliver projects on time, within budget and of defined quality. However, there is little published information describing its use in managing health and medical research projects. We used project management in the Alcohol and Pregnancy Project (2006-2008 http://www.ichr.uwa.edu.au/alcoholandpregnancy and in this paper report researchers' opinions on project management and whether it made a difference to the project. Methods A national interdisciplinary group of 20 researchers, one of whom was the project manager, formed the Steering Committee for the project. We used project management to ensure project outputs and outcomes were achieved and all aspects of the project were planned, implemented, monitored and controlled. Sixteen of the researchers were asked to complete a self administered questionnaire for a post-project review. Results The project was delivered according to the project protocol within the allocated budget and time frame. Fifteen researchers (93.8% completed a questionnaire. They reported that project management increased the effectiveness of the project, communication, teamwork, and application of the interdisciplinary group of researchers' expertise. They would recommend this type of project management for future projects. Conclusions Our post-project review showed that researchers comprehensively endorsed project management in the Alcohol and Pregnancy Project and agreed that project management had contributed substantially to the research. In future, we will project manage new projects and conduct post-project reviews. The results will be used to encourage continuous learning and continuous improvement of project management, and provide greater transparency and accountability of health and medical research. The use of project management can benefit both management and scientific outcomes of health and medical research projects.

  5. Advanced energy projects FY 1983 research summaries

    International Nuclear Information System (INIS)

    This Division supports exploratory research on novel concepts related to energy. The research is usually aimed at establishing the scientific feasibility of a concept and, where appropriate, also at estimating its economic viability. Because projects supported inevitably involve a high degree of risk, an indication of a high potential payoff is required. An immediate, specific application of the concept is not an absolute prerequisite for consideration; thus, for example, proposers of schemes leading to the development of x-ray lasers are not required to justify their proposals by discussing potential applications of such lasers. The concepts supported are typically at too early a stage of scientific verification to qualify for funding by DOE programs responsible for technology development. Where doubt exists, such programs are consulted, prior to proposal consideration by AEP, in order to establish their possible interest in the project

  6. Integrative computational biology for cancer research

    OpenAIRE

    Fortney, Kristen; Jurisica, Igor

    2011-01-01

    Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed clinical cancer research. They have revealed novel molecular markers of cancer subtypes, metastasis, and drug sensitivity and resistance. Some have been translated into the clinic as tools for early disease diagnosis, prognosis, and individualized treatment and response monitoring. Despite these successes, many challenges remain: HTP platforms are often noisy and ...

  7. On-going research projects at Ankara Nuclear Research Center in Agriculture and Animal Science

    International Nuclear Information System (INIS)

    Full text: The research and development activities of Ankara Nuclear Research Center in Agriculture and Animal Science(ANRCAA) are concentrated on the contribution of atomic energy to peace by the use of nuclear and related techniques in food, agriculture and animal science. Nuclear techniques are used in the above fields in two ways: in vitro or in vivo radio tracing the substances and processes of biological importance, and irradiation of biological materials for preservation and quality modification. Research projects are carried out by interdisciplinary studies with well equipped laboratories at the Center. The projects in progress conducted by the Center comprises nuclear-aided researches in soil fertility, plant nutrition, plant protection, improvement of field crops, improvement of horticultural plants and forest trees by mutation breeding, in vitro culture technique with mutagen treatments, use of phosphogypsum in soil amelioration, sterilization of medical supplies, wastewater treatment, animal nutrition, animal health and productivity and accreditation. The on-going projects with the above subjects will be summarized for possible collaborations

  8. Quarterly report of Biological and Medical Research Division, April 1955

    Energy Technology Data Exchange (ETDEWEB)

    Brues, A.M.

    1955-04-01

    This report is a compilation of 48 investigator prepared summaries of recent progress in individual research programs of the Biology and Medical Division of the Argonne National Laboratory for the quarterly period ending April,1955. Individual reports are about 3-6 pages in length and often contain research data.

  9. Abstract and research accomplishments of University Coal Research Projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their respective projects in time for distribution at a conference on June 13--14, 1995 at Tennessee State University in Nashville, Tennessee. This book is a compilation of the material received in response to that request. For convenience, the 70 grants reported in this book are stored into eight technical areas, Coal Science, Coal Surface Science, Reaction Chemistry, Advanced Process Concepts, Engineering Fundamentals and Thermodynamics, Environmental Science, high Temperature Phenomena, and Special topics. Indexes are provided for locating projects by subject, principal investigators, and contracting organizations. Each extended abstract describes project objectives, work accomplished, significance to the Fossil Energy Program, and plans for the next year.

  10. National inventory of selected biological monitoring programs. Summary report of current or recently completed projects, 1976

    Energy Technology Data Exchange (ETDEWEB)

    Kemp, H. T.

    1976-10-01

    The Inventory has resulted in establishment of a series of data bases containing biological monitoring information of varying types, namely, directory of investigators, record of projects received from mail questionnaire, detailed description of selected biomonitoring projects, and bibliographic citations supporting the projects received. This report contains detailed descriptions of selected biomonitoring projects organized on a state-by-state basis and with appropriate indices.

  11. The project as product of scientific research

    Directory of Open Access Journals (Sweden)

    Mario Losasso

    2011-11-01

    Full Text Available The topic of project as product of research for the Area of Architecture can be considered therefore central for tradition, for the recognized value on social, economic and environmental effects of the works of architecture and, finally, for the declared accreditation from scientific bodies and evaluation structures of Athenaeums. As it is not reasonable to imagine an automatic correspondence between project and its research value, such value is clearly verifiable when for it are underlined specific qualifications in base to genetic peculiarity, to particular operational developments, to exemplary modes of production, to evident cultural, social, economic and environmen- tal effects. Within the various components of the design introduced recently by the CUN (National University Council, the reference of technological design to the problem solving field, in which it is possible to organize decision-making abilities and manage information for the project success, refers to the knowledge fields and to the activities that interact with the know-how, with the method and with the simultaneity of theoretical and prac- tical knowledge.

  12. Rehabilitation of European Biological Soil Crusts - The SCIN project

    Science.gov (United States)

    Williams, Laura; Zheng, Lingjuan; Maier, Stefanie; Weber, Bettina; Büdel, Burkhard

    2015-04-01

    The ''Soil Crust INternational'' (SCIN) Project aims to improve the appreciation and understanding of European Biological Soil Crusts (BSC) with the goal of developing biodiversity conservation and sustainable management strategies. Our objective is to study the uniqueness of European BSC on a local scale and investigate how these communities thrive in areas with such great macroclimatic differences. In order to cover a wide diversity of European BSC a latitudinal transect was established, extending from the Great Alvar of Öland, Sweden in the north, down to Gössenheim, Central Germany and Hochtor in the Hohe Tauern National Park, Austria, continuing to the Badlands of Tabernas, in southern Spain. The transect stretches over 20° latitude and 2,300 m in altitude and includes natural and also semi-natural sites that require maintenance, for instance, by grazing. Within the SCIN project a rehabilitation study was initiated in order to investigate the recovery potential of BSC under different environmental conditions. This entailed the construction of 10 times 1m2 plots, alongside control plots, at each of the 4 sites, where the BSC was completely removed. Over the course of 2 years (2012-2014) the plots were sampled regularly to assess recovery in the form of returning organisms (cyanobacteria, algae, lichens, bryophytes, higher plants), soil stability, chlorophyll and carbon content and nutrient composition. Cyanobacteria are considered as the pioneering functional group of BSC establishment in many regions, especially arid, and may be critical for the successful formation of any of the further BSC successional stages. Therefore, the cyanobacterial assemblages of recovering plots are being investigated to shed light on the importance of cyanobacteria in the rehabilitation of BSC and whether individual species or specific communities can be ascribed to a local or wide geographical range. It also has to be considered the proximity of recovering BSC to established

  13. Annual review of research projects 1987

    International Nuclear Information System (INIS)

    The Australian Radiation Laboratory is a national laboratory whose function is to assist the users of radiation, and those who regulate its use, to ensure that wherever radiation is encountered, it is managed in the safest possible way. In performing this function the Laboratory conducts a varied program of applied research in areas which have implications for occupational or public health. This progress report provides a brief outline of current Laboratory research and development projects and their present status. The material is grouped into the following research fields: uranium, radon and its daughters; environmental radiation monitoring; radiopharmaceuticals and nuclear medicine; X-ray and clinical dosimetry; radionuclide metrology; non-ionising electromagnetic radiations; measurement standards in radiation dosimetry; and radiation effects in solids and gases. Refs., figs., tabs

  14. The dilemma of dual use biological research: Polish perspective.

    Science.gov (United States)

    Czarkowski, Marek

    2010-03-01

    Biological research with legitimate scientific purpose that may be misused to pose a biological threat to public health and/or national security is termed dual use. In Poland there are adequate conditions for conducting experiments that could be qualified as dual use research, and therefore, a risk of attack on Poland or other countries exists. Optimal solutions for limiting such threats are required, and the national system of biosecurity should enable early, reliable, and complete identification of this type of research. Scientists should have a fundamental role in this process, their duty being to immediately, upon identification, report research with dual use potential. An important entity in the identification system of dual use research should also be the Central Register of Biological and Biomedical Research, which gathers information about all biological and biomedical research being conducted in a given country. Publishers, editors, and review committees of journals and other scientific publications should be involved in evaluating results of clinical trials. The National Council of Biosecurity should be the governmental institution responsible for developing a system of dual use research threat prevention. Its role would be to develop codes of conduct, form counsel of expertise, and monitor the problem at national level, while the Dual Use Research Committee would be responsible for individual cases. In Poland, current actions aiming to provide biological safety were based on developing and passing an act about genetically modified organisms (GMO's) and creating a GMO Committee. Considering experiences of other nations, one should view these actions as fragmentary, and thus insufficient protection against dual use research threats. PMID:18546061

  15. Abstracts and research accomplishments of university coal research projects

    International Nuclear Information System (INIS)

    The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their projects in time for distribution at a grantees conference. This book is a compilation of the material received in response to the request. Abstracts discuss the following area: coal science, coal surface science, reaction chemistry, advanced process concepts, engineering fundamentals and thermodynamics, environmental science

  16. Abstracts and research accomplishments of university coal research projects

    Energy Technology Data Exchange (ETDEWEB)

    1991-06-01

    The Principal Investigators of the grants supported by the University Coal Research Program were requested to submit abstracts and highlight accomplishments of their projects in time for distribution at a grantees conference. This book is a compilation of the material received in response to the request. Abstracts discuss the following area: coal science, coal surface science, reaction chemistry, advanced process concepts, engineering fundamentals and thermodynamics, environmental science.

  17. Biological and Physical Space Research Laboratory 2002 Science Review

    Science.gov (United States)

    Curreri, P. A. (Editor); Robinson, M. B. (Editor); Murphy, K. L. (Editor)

    2003-01-01

    With the International Space Station Program approaching core complete, our NASA Headquarters sponsor, the new Code U Enterprise, Biological and Physical Research, is shifting its research emphasis from purely fundamental microgravity and biological sciences to strategic research aimed at enabling human missions beyond Earth orbit. Although we anticipate supporting microgravity research on the ISS for some time to come, our laboratory has been vigorously engaged in developing these new strategic research areas.This Technical Memorandum documents the internal science research at our laboratory as presented in a review to Dr. Ann Whitaker, MSFC Science Director, in July 2002. These presentations have been revised and updated as appropriate for this report. It provides a snapshot of the internal science capability of our laboratory as an aid to other NASA organizations and the external scientific community.

  18. Bringing the physical sciences into your cell biology research

    OpenAIRE

    Robinson, Douglas N; Iglesias, Pablo A.

    2012-01-01

    Historically, much of biology was studied by physicists and mathematicians. With the advent of modern molecular biology, a wave of researchers became trained in a new scientific discipline filled with the language of genes, mutants, and the central dogma. These new molecular approaches have provided volumes of information on biomolecules and molecular pathways from the cellular to the organismal level. The challenge now is to determine how this seemingly endless list of components works toget...

  19. Improving undergraduate biology education in a large research university.

    OpenAIRE

    Bender, C; Ward, S; Wells, M A

    1994-01-01

    The campus-wide Undergraduate Biology Research Program (UBRP) at the University of Arizona improves undergraduate science education by expanding student opportunities for independent research in faculty laboratories. Within the supportive community of a research laboratory, underclassmen, nonscience majors, and those aspiring to scientific careers all learn to appreciate the process of science. The Program impacts more than the students, promoting departmental cooperation, interdisciplinary c...

  20. Flash for Biological Dosimetry Experiments- A BEXUS 16 Project

    Science.gov (United States)

    Bigge, K.; Cermak, D.; Schuberg, V.; Guerin, E. A.; Blessenohl, M. A.; Passenberg, F.; Bach, M.; Hausmann, M.; Hildenbrand, G.

    2015-09-01

    The effects of low dose radiation on living organisms are still topic of current research and radiation protection. Complex compound radiation, such as of cosmic origin, is of special interest, since it is of pivotal significance for human space flight and, in the long run, cancer research. Fluid LAb in the StratospHere (FLASH) is a Heidelberg University student project that transported specimens of living cells of human origin into the stratosphere to investigate the effects of cosmic radiation on the 3D chromatin nanostructure of their genome. Since, owing to its complexity, cosmic radiation is extremely difficult to replicate on the ground, the FLASH project took part in the BEXUS (Balloon Experiments for University Students) program of the German Aerospace Center (DLR) and the Swedish National Space Board (SNSB) to use a balloon to get better access to cosmic radiation over several hours. To keep the cells alive and allow for in-flight fixation after given radiation exposure times in order to prevent restorative processes, a compact and fully automated fluid lab suited for low-pressure environments was designed and built. Challenges included fluid exchange of specimen buffers and temperature control, as well as low-budget insulating mounting. After the flight, the specimens fixed during the flight were subjected to further analysis. After antibody labeling specific against heterochromatin, Spectral Precision Distance Microscopy (SPDM) (an embodiment of super-resolution localization microscopy) was used, which is a new approach for the sensitive detection and analysis of structure modifying irradiation effects on organisms. This technique allows light resolution on the order of tens of nanometers. Preliminary evaluation of the data indicated reasonable differences in chromatin conformation compared to control specimen data.

  1. NASA Space Biology Plant Research for 2010-2020

    Science.gov (United States)

    Levine, H. G.; Tomko, D. L.; Porterfield, D. M.

    2012-01-01

    The U.S. National Research Council (NRC) recently published "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog.php?record id=13048), and NASA completed a Space Biology Science Plan to develop a strategy for implementing its recommendations ( http://www.nasa.gov/exploration/library/esmd documents.html). The most important recommendations of the NRC report on plant biology in space were that NASA should: (1) investigate the roles of microbial-plant systems in long-term bioregenerative life support systems, and (2) establish a robust spaceflight program of research analyzing plant growth and physiological responses to the multiple stimuli encountered in spaceflight environments. These efforts should take advantage of recently emerged analytical technologies (genomics, transcriptomics, proteomics, metabolomics) and apply modern cellular and molecular approaches in the development of a vigorous flight-based and ground-based research program. This talk will describe NASA's strategy and plans for implementing these NRC Plant Space Biology recommendations. New research capabilities for Plant Biology, optimized by providing state-of-the-art automated technology and analytical techniques to maximize scientific return, will be described. Flight experiments will use the most appropriate platform to achieve science results (e.g., ISS, free flyers, sub-orbital flights) and NASA will work closely with its international partners and other U.S. agencies to achieve its objectives. One of NASA's highest priorities in Space Biology is the development research capabilities for use on the International Space Station and other flight platforms for studying multiple generations of large plants. NASA will issue recurring NASA Research Announcements (NRAs) that include a rapid turn-around model to more fully engage the biology community in designing experiments to respond to the NRC recommendations. In doing so, NASA

  2. Annual review of research projects 1985

    International Nuclear Information System (INIS)

    This progress report provides a brief outline of current Laboratory research and development projects and their present status. The material has been grouped into the following fields: uranium, radon and its daughters; radiation effects in solids and gases; x-rays and clinical dosimetry, measurement standards in radiation dosimetry; radiopharmaceuticals and nuclear medicine; non-ionising electromagnetic radiation; environmental radiochemistry and radiation monitoring. The last category includes residual radioactive contamination at Maralinga, Emu and the Monte Bello Islands from British nuclear weapons tests in Australia, and the public health impact of fall-out from those tests

  3. The Undergraduate ALFALFA Team: Collaborative Research Projects

    Science.gov (United States)

    Cannon, John M.; Koopmann, Rebecca A.; Haynes, Martha P.; Undergraduate ALFALFA Team, ALFALFA Team

    2016-01-01

    The NSF-sponsored Undergraduate ALFALFA (Arecibo Legacy Fast ALFA) Team (UAT) has allowed faculty and students from a wide range of public and private colleges and especially those with small astronomy programs to learn how science is accomplished in a large collaboration while contributing to the scientific goals of a legacy radio astronomy survey. The UAT has achieved this through close collaboration with ALFALFA PIs to identify research areas accessible to undergraduates. In this talk we will summarize the main research efforts of the UAT, including multiwavelength followup observations of ALFALFA sources, the UAT Collaborative Groups Project, the Survey of HI in Extremely Low-mass Dwarfs (SHIELD), and the Arecibo Pisces-Perseus Supercluster Survey. This work has been supported by NSF grants AST-0724918/0902211, AST-075267/0903394, AST-0725380, and AST-1211005.

  4. National Storage Laboratory: a collaborative research project

    Science.gov (United States)

    Coyne, Robert A.; Hulen, Harry; Watson, Richard W.

    1993-01-01

    The grand challenges of science and industry that are driving computing and communications have created corresponding challenges in information storage and retrieval. An industry-led collaborative project has been organized to investigate technology for storage systems that will be the future repositories of national information assets. Industry participants are IBM Federal Systems Company, Ampex Recording Systems Corporation, General Atomics DISCOS Division, IBM ADSTAR, Maximum Strategy Corporation, Network Systems Corporation, and Zitel Corporation. Industry members of the collaborative project are funding their own participation. Lawrence Livermore National Laboratory through its National Energy Research Supercomputer Center (NERSC) will participate in the project as the operational site and provider of applications. The expected result is the creation of a National Storage Laboratory to serve as a prototype and demonstration facility. It is expected that this prototype will represent a significant advance in the technology for distributed storage systems capable of handling gigabyte-class files at gigabit-per-second data rates. Specifically, the collaboration expects to make significant advances in hardware, software, and systems technology in four areas of need, (1) network-attached high performance storage; (2) multiple, dynamic, distributed storage hierarchies; (3) layered access to storage system services; and (4) storage system management.

  5. Researchers' experiences, positive and negative, in integrative landscape projects

    OpenAIRE

    Tress, B.; Tress, G.; Fry, G.

    2005-01-01

    Integrative (interdisciplinary and transdisciplinary) landscape research projects are becoming increasingly common. As a result, researchers are spending a larger proportion of their professional careers doing integrative work, participating in shifting interdisciplinary teams, and cooperating directly with non-academic participants. Despite the growing importance of integrative research, few studies have investigated researchers¿ experiences in these projects. How do researchers perceive the...

  6. Tools for Monitoring Social Media: A Marketing Research Project

    Science.gov (United States)

    Veeck, Ann; Hoger, Beth

    2014-01-01

    Knowledge of how to effectively monitor social media is an increasingly valued marketing research skill. This study tests an approach for adding social media content to an undergraduate marketing research class team project. The revised project maintains the expected objectives and parameters of a traditional research project, while integrating…

  7. Bibliographical review on the teaching of Biology and research

    Directory of Open Access Journals (Sweden)

    Mª Luz Rodríguez Palmero

    2000-09-01

    Full Text Available This review complements another one done by the same author, in 1997, regarding the role of comprehending the concept of cell in the learning of Biology. In addition, some general papers on science education that provide a better understanding of research approaches used in the investigation of this topic have been included. The reviewed papers have been organized into categories according to the object of study, the relevance assigned to the cell concept, and the framework of analysis. The review shows that the concept of cell is very important in the biological conceptualization, however, it also shows the need of additional research on this matter, from theoretical frameworks that pay more attention to the psychological level, in order to provide some guidance to improve the teaching and learning processes of the biological content that presupose the comprehension of living beings.

  8. Biological Sample Ambient Preservation (BioSAP) Device Project

    Data.gov (United States)

    National Aeronautics and Space Administration — To address NASA's need for alternative methods for ambient preservation of human biological samples collected during extended spaceflight and planetary operations,...

  9. In focus: molecular and cell biology research in China.

    Science.gov (United States)

    Yao, Xuebiao; Li, Dangsheng; Pei, Gang

    2013-09-01

    An interactive, intellectual environment with good funding opportunities is essential for the development and success of basic research. The fast-growing economy and investment in science, together with a visionary plan, have attracted foreign scholars to work in China, motivated world-class Chinese scientists to return and strengthened the country's international collaborations. As a result, molecular and cell biology research in China has evolved rapidly over the past decade.

  10. Biologically Enhanced Carbon Sequestration: Research Needs and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Oldenburg, Curtis; Oldenburg, Curtis M.; Torn, Margaret S.

    2008-03-21

    Fossil fuel combustion, deforestation, and biomass burning are the dominant contributors to increasing atmospheric carbon dioxide (CO{sub 2}) concentrations and global warming. Many approaches to mitigating CO{sub 2} emissions are being pursued, and among the most promising are terrestrial and geologic carbon sequestration. Recent advances in ecology and microbial biology offer promising new possibilities for enhancing terrestrial and geologic carbon sequestration. A workshop was held October 29, 2007, at Lawrence Berkeley National Laboratory (LBNL) on Biologically Enhanced Carbon Sequestration (BECS). The workshop participants (approximately 30 scientists from California, Illinois, Oregon, Montana, and New Mexico) developed a prioritized list of research needed to make progress in the development of biological enhancements to improve terrestrial and geologic carbon sequestration. The workshop participants also identified a number of areas of supporting science that are critical to making progress in the fundamental research areas. The purpose of this position paper is to summarize and elaborate upon the findings of the workshop. The paper considers terrestrial and geologic carbon sequestration separately. First, we present a summary in outline form of the research roadmaps for terrestrial and geologic BECS. This outline is elaborated upon in the narrative sections that follow. The narrative sections start with the focused research priorities in each area followed by critical supporting science for biological enhancements as prioritized during the workshop. Finally, Table 1 summarizes the potential significance or 'materiality' of advances in these areas for reducing net greenhouse gas emissions.

  11. The Research Proposal in Biomechanical and Biological Engineering Courses

    Science.gov (United States)

    Harrison, Roger G.; Nollert, Matthias U.; Schmidtke, David W.; Sikavitsas, Vassilios I.

    2006-01-01

    Students in four biochemical and biological engineering courses for upper-­level undergraduates and graduate students were required to write a research proposal. Breaking the requirements down into segments (such as a summary with specific aims, rough draft, and final draft) due on different dates helped make the assignment more manageable for the…

  12. Fast Charging Electric Vehicle Research & Development Project

    Energy Technology Data Exchange (ETDEWEB)

    Heny, Michael

    2014-03-31

    The research and development project supported the engineering, design and implementation of on-road Electric Vehicle (“EV”) charging technologies. It included development of potential solutions for DC fast chargers (“DCFC”) capable of converting high voltage AC power to the DC power required by EVs. Additional development evaluated solutions related to the packaging of power electronic components and enclosure design, as well as for the design and evaluation of EV charging stations. Research compared different charging technologies to identify optimum applications in a municipal fleet. This project collected EV usage data and generated a report demonstrating that EVs, when supported by adequate charging infrastructure, are capable of replacing traditional internal combustion vehicles in many municipal applications. The project’s period of performance has demonstrated various methods of incorporating EVs into a municipal environment, and has identified three general categories for EV applications: - Short Commute: Defined as EVs performing in limited duration, routine commutes. - Long Commute: Defined as tasks that require EVs to operate in longer daily mileage patterns. - Critical Needs: Defined as the need for EVs to be ready at every moment for indefinite periods. Together, the City of Charlottesville, VA (the “City”) and Aker Wade Power Technologies, LLC (“Aker Wade”) concluded that the EV has a viable position in many municipal fleets but with limited recommendation for use in Critical Needs applications such as Police fleets. The report also documented that, compared to internal combustion vehicles, BEVs have lower vehicle-related greenhouse gas (“GHG”) emissions and contribute to a reduction of air pollution in urban areas. The enhanced integration of EVs in a municipal fleet can result in reduced demand for imported oil and reduced municipal operating costs. The conclusions indicated in the project’s Engineering Report (see

  13. Proceedings of the public meeting to address a proposed federal radiation research agenda. Volume 2. Science projection papers

    International Nuclear Information System (INIS)

    Separate abstracts were prepared for the 14 science projection papers presented at a public meeting on March 10-11, 1980 to address a proposed federal radiation research agenda into the biological effects of ionizing radiation

  14. Astronomy Legacy Project - Pisgah Astronomical Research Institute

    Science.gov (United States)

    Barker, Thurburn; Castelaz, Michael W.; Rottler, Lee; Cline, J. Donald

    2016-01-01

    Pisgah Astronomical Research Institute (PARI) is a not-for-profit public foundation in North Carolina dedicated to providing hands-on educational and research opportunities for a broad cross-section of users in science, technology, engineering and math (STEM) disciplines. In November 2007 a Workshop on a National Plan for Preserving Astronomical Photographic Data (2009ASPC,410,33O, Osborn, W. & Robbins, L) was held at PARI. The result was the establishment of the Astronomical Photographic Data Archive (APDA) at PARI. In late 2013 PARI began ALP (Astronomy Legacy Project). ALP's purpose is to digitize an extensive set of twentieth century photographic astronomical data housed in APDA. Because of the wide range of types of plates, plate dimensions and emulsions found among the 40+ collections, plate digitization will require a versatile set of scanners and digitizing instruments. Internet crowdfunding was used to assist in the purchase of additional digitization equipment that were described at AstroPlate2014 Plate Preservation Workshop (www.astroplate.cz) held in Prague, CZ, March, 2014. Equipment purchased included an Epson Expression 11000XL scanner and two Nikon D800E cameras. These digital instruments will compliment a STScI GAMMA scanner now located in APDA. GAMMA will be adapted to use an electroluminescence light source and a digital camera with a telecentric lens to achieve high-speed high-resolution scanning. The 1μm precision XY stage of GAMMA will allow very precise positioning of the plate stage. Multiple overlapping CCD images of small sections of each plate, tiles, will be combined using a photo-mosaic process similar to one used in Harvard's DASCH project. Implementation of a software pipeline for the creation of a SQL database containing plate images and metadata will be based upon APPLAUSE as described by Tuvikene at AstroPlate2014 (www.astroplate.cz/programs/).

  15. LifeSat - A satellite for space biological research

    Science.gov (United States)

    Halstead, Thora W.; Morey-Holton, Emily R.

    1990-01-01

    The LifeSat Program addresses the need for continuing access by biological scientists to space experimentation by accommodating a wide range of experiments involving animals and plants for durations up to 60 days in an unmanned satellite. The program will encourage interdisciplinary and international cooperation at both the agency and scientist levels, and will provide a recoverable, reusable facility for low-cost missions addressing key scientific issues that can only be answered by space experimentation. It will provide opportunities for research in gravitational biology and on the effects of cosmic radiation on life systems. The scientific aspects of LifeSat are addressed here.

  16. The solar system: Importance of research to the biological sciences

    Science.gov (United States)

    Klein, Harold P.

    1992-01-01

    An attempt is made to describe the scope of scientific areas that comprise the current field of exobiology in the United States. From investigations of astrophysical phenomena that deal with the birth of stars and planetary systems to questions of molecular biology involving phylogenetic relationships among organisms, from attempts to simulate the synthesis of biological precursor molecules in the chemistry laboratory to making measurements of the organic constituents of Titan's atmosphere, these researches all converge toward a common objective--answering the question of how life came about in the universe.

  17. Stem Cells: A Renaissance in Human Biology Research.

    Science.gov (United States)

    Wu, Jun; Izpisua Belmonte, Juan Carlos

    2016-06-16

    The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.

  18. The use of SIMS for uranium localization in biological research

    International Nuclear Information System (INIS)

    Secondary ion mass spectrometry (SIMS) enables the localization and isotopic determination in microvolume of all elements from the Mendeleyev table. Based on the ablation of samples by ion bombardment, the SIMS method allows rapid assessment of trace elements in biological samples. In this work, studies in vitro and in vivo have been carried out using, respectively, rat macrophages and lung tissue sections containing uranium oxides. Following the localization studies, the isotopic ratio between the 235U and 238U was measured. In the present work, analytical procedures and the potential of the SIMS in biological research are discussed. (orig.)

  19. Evaluation of failure or deficient performance factors of approved research projects by TUMS research council

    OpenAIRE

    Zarinara A.; Alaedini F.

    2002-01-01

    The major activity for vice chancellor for research at Tehran University of Medical Sciences (TUMS) is to monitor research projects undertaken by the academic staff. Sometimes projects have been failed in meeting their objectives. The aim of this project was the evaluation of the failure of the research projects at TUMS from the establishment date to 1379. A case-control survey was designed and 70 failed projects with 71 successfully completed projects were considered and compared. Results sh...

  20. 30 CFR 402.10 - Research-project applications.

    Science.gov (United States)

    2010-07-01

    ... project title, project objectives, background information, research tasks, methodology to conduct the... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Research-project applications. 402.10 Section... PROGRAM AND THE WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Application, Evaluation, and...

  1. Invited Review Article: Advanced light microscopy for biological space research

    Energy Technology Data Exchange (ETDEWEB)

    De Vos, Winnok H., E-mail: winnok.devos@uantwerpen.be [Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp (Belgium); Cell Systems and Imaging Research Group, Department of Molecular Biotechnology, Ghent University, Ghent (Belgium); Beghuin, Didier [Lambda-X, Nivelles (Belgium); Schwarz, Christian J. [European Space Agency (ESA), ESTEC, TEC-MMG, Noordwijk (Netherlands); Jones, David B. [Institute for Experimental Orthopaedics and Biomechanics, Philipps University, Marburg (Germany); Loon, Jack J. W. A. van [Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center and Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, Amsterdam (Netherlands); Bereiter-Hahn, Juergen; Stelzer, Ernst H. K. [Physical Biology, BMLS (FB15, IZN), Goethe University, Frankfurt am Main (Germany)

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  2. Invited Review Article: Advanced light microscopy for biological space research

    Science.gov (United States)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; van Loon, Jack J. W. A.; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  3. 2003 Biology and Biotechnology Research Program Overview and Highlights

    Energy Technology Data Exchange (ETDEWEB)

    Prange, C

    2003-03-01

    LLNL conducts multidisciplinary bioscience to fill national needs. Our primary roles are to: develop knowledge and tools which enhance national security, including biological, chemical and nuclear capabilities, and energy and environmental security; develop understanding of genetic and biochemical processes to enhance disease prevention, detection and treatment; develop unique biochemical measurement and computational modeling capabilities which enable understanding of biological processes; and develop technology and tools which enhance healthcare. We execute our roles through integrated multidisciplinary programs that apply our competencies in: microbial and mammalian genomics--the characterization of DNA, the genes it encodes, their regulation and function and their role in living systems; protein function and biochemistry - the structure, function, and interaction of proteins and other molecules involved in the integrated biochemical function of the processes of life; computational modeling and understanding of biochemical systems--the application of high-speed computing technology to simulate and visualize complex, integrated biological processes; bioinformatics--databasing, networking, and analysis of biological data; and bioinstrumentation--the application of physical and engineering technologies to novel biological and biochemical measurements, laboratory automation, medical device development, and healthcare technologies. We leverage the Laboratory's exceptional capabilities in the physical, computational, chemical, environmental and engineering sciences. We partner with industry and universities to utilize their state-of-the art technology and science and to make our capabilities and discoveries available to the broader research community.

  4. Current severe accident research facilities and projects

    International Nuclear Information System (INIS)

    The Working Group on the Analysis and Management of Accidents (GAMA) is mainly composed of technical specialists in the areas of coolant system thermal-hydraulics, in-vessel protection, containment protection, and fission product retention. Its general functions include the exchange of information on national and international activities in these areas, the exchange of detailed technical information, and the discussion of progress achieved in respect of specific technical issues. Severe accident management is one of the important tasks of the group. This document is an update of the 'Current Severe Accident Research Facilities and Projects' list. Facilities and projects are sorted according to the following criteria: In-Vessel Phenomena: Core Degradation and Melt Progression, Molten Core Debris Interaction with the Reactor Pressure Vessel Lower Head and Mechanical Behaviour of Reactor Pressure Vessel Lower Head; In-Vessel and Ex-Vessel Molten Fuel/Coolant Interactions; Ex-Vessel Phenomena: Molten Core Debris/Concrete Interactions, Molten Core/Ceramic Interaction, Melt Release (including DCH), Melt Spreading and Catching Devices Studies, Melt Coolability, Corium Melt properties; Hydrogen Transport and Combustion: Mixing and Distribution, Deflagration, Deflagration-to-Detonation Transition, Passive Recombiner Performance; Mechanical Behaviour of Reactor Pressure Vessel Lower Head; Containment Structural Integrity: Containment Failure Experiment and Analysis, Material Properties and Structural Behaviour, Containment Thermal-Hydraulics, Containment Cooling, Cable Penetration Integrity; Fission Products and Aerosols: Effects of Specific Elements on Iodine Volatility, Release of Low-Volatility Fission Products/Late In-Vessel Fission Product Release, Reactor Materials Release, Aerosol and Iodine Behaviour in Reactor Coolant System and Containment, Retention, Resuspension and Revaporization in Primary Circuit, Aerosol Nucleation and Transport, Source Term, Containment

  5. 77 FR 40590 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-07-10

    ... Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program; Disability... Rehabilitation Research Projects and Centers Program--Disability and Rehabilitation Research Projects--Burn Model... Rehabilitation Research Projects and Centers Program-- Disability and Rehabilitation Research...

  6. Research Applications of Proteolytic Enzymes in Molecular Biology

    Directory of Open Access Journals (Sweden)

    József Tőzsér

    2013-11-01

    Full Text Available Proteolytic enzymes (also termed peptidases, proteases and proteinases are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications require their use, including production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, cell culturing and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics and therapy, exploration of the structure-function relationships by structural studies, removal of affinity tags from fusion proteins in recombinant protein techniques, peptide sequencing and proteolytic digestion of proteins in proteomics. The aim of this paper is to review the molecular biological aspects of proteolytic enzymes and summarize their applications in the life sciences.

  7. Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project

    Science.gov (United States)

    Taylor, Chris F; Field, Dawn; Sansone, Susanna-Assunta; Aerts, Jan; Apweiler, Rolf; Ashburner, Michael; Ball, Catherine A; Binz, Pierre-Alain; Bogue, Molly; Booth, Tim; Brazma, Alvis; Brinkman, Ryan R; Clark, Adam Michael; Deutsch, Eric W; Fiehn, Oliver; Fostel, Jennifer; Ghazal, Peter; Gibson, Frank; Gray, Tanya; Grimes, Graeme; Hancock, John M; Hardy, Nigel W; Hermjakob, Henning; Julian, Randall K; Kane, Matthew; Kettner, Carsten; Kinsinger, Christopher; Kolker, Eugene; Kuiper, Martin; Le Novère, Nicolas; Leebens-Mack, Jim; Lewis, Suzanna E; Lord, Phillip; Mallon, Ann-Marie; Marthandan, Nishanth; Masuya, Hiroshi; McNally, Ruth; Mehrle, Alexander; Morrison, Norman; Orchard, Sandra; Quackenbush, John; Reecy, James M; Robertson, Donald G; Rocca-Serra, Philippe; Rodriguez, Henry; Rosenfelder, Heiko; Santoyo-Lopez, Javier; Scheuermann, Richard H; Schober, Daniel; Smith, Barry; Snape, Jason; Stoeckert, Christian J; Tipton, Keith; Sterk, Peter; Untergasser, Andreas; Vandesompele, Jo; Wiemann, Stefan

    2009-01-01

    The Minimum Information for Biological and Biomedical Investigations (MIBBI) project provides a resource for those exploring the range of extant minimum information checklists and fosters coordinated development of such checklists. PMID:18688244

  8. Robotic, MEMS-based Multi Utility Sample Preparation Instrument for ISS Biological Workstation Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This project will develop a multi-functional, automated sample preparation instrument for biological wet-lab workstations on the ISS. The instrument is based on a...

  9. Winter report on biological projects : Des Lacs and Lostwood Migratory Bird Refuge : 1935-1936

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — Report on biological projects taking place during the winter of 1935-1936 on Des Lacs National Wildlife Refuge and Lostwood National Wildlife Refuge. Activities...

  10. The Systems Biology Research Tool: evolvable open-source software

    OpenAIRE

    Wright Jeremiah; Wagner Andreas

    2008-01-01

    Abstract Background Research in the field of systems biology requires software for a variety of purposes. Software must be used to store, retrieve, analyze, and sometimes even to collect the data obtained from system-level (often high-throughput) experiments. Software must also be used to implement mathematical models and algorithms required for simulation and theoretical predictions on the system-level. Results We introduce a free, easy-to-use, open-source, integrated software platform calle...

  11. Quality of histone modification antibodies undermines chromatin biology research

    OpenAIRE

    Goran Kungulovski; Albert Jeltsch

    2015-01-01

    Histone post-translational modification (PTM) antibodies are essential research reagents in chromatin biology. However, they suffer from variable properties and insufficient documentation of quality. Antibody manufacturers and vendors should provide detailed lot-specific documentation of quality, rendering further quality checks by end-customers unnecessary. A shift from polyclonal antibodies towards sustainable reagents like monoclonal or recombinant antibodies or histone binding domains wou...

  12. BRIC-60: Biological Research in Canisters (BRIC)-60

    Science.gov (United States)

    Richards, Stephanie E. (Compiler); Levine, Howard G.; Romero, Vergel

    2016-01-01

    The Biological Research in Canisters (BRIC) is an anodized-aluminum cylinder used to provide passive stowage for investigations evaluating the effects of space flight on small organisms. Specimens flown in the BRIC 60 mm petri dish (BRIC-60) hardware include Lycoperscion esculentum (tomato), Arabidopsis thaliana (thale cress), Glycine max (soybean) seedlings, Physarum polycephalum (slime mold) cells, Pothetria dispar (gypsy moth) eggs and Ceratodon purpureus (moss).

  13. Biological research of Grabia River - fifty years of activity

    OpenAIRE

    Siciński, Jacek; Tończyk, Grzegorz

    2005-01-01

    Grabia, a small still close to natural conditions lowland river, has been an object of special interest for Łódź hydrobiologists for more than 50 years. Over 100 scientific papers and over 100 master theses were produced in the Faculty of Biology and Environmental Protection University of Łódź. The initiator was Prof.L.K. Pawłowski who spent many years conducting research into the river. The ground and the first research objective was to recognize the fauna diversity. The checklis...

  14. Evaluation of failure or deficient performance factors of approved research projects by TUMS research council

    Directory of Open Access Journals (Sweden)

    Zarinara A.

    2002-08-01

    Full Text Available The major activity for vice chancellor for research at Tehran University of Medical Sciences (TUMS is to monitor research projects undertaken by the academic staff. Sometimes projects have been failed in meeting their objectives. The aim of this project was the evaluation of the failure of the research projects at TUMS from the establishment date to 1379. A case-control survey was designed and 70 failed projects with 71 successfully completed projects were considered and compared. Results showed that type of study, location of administration, methodology, qualification of executive and duration of project were the factors of failure of the projects. Number of executives, experienced in research projects and executive position were not the effective factors. The most important reason for failure was unsustainably of executive. So, university research council (URC should pay attention on forecast of time and budget of projects and realization of mentioned matters, besides of attention to methodology of project.

  15. Division of Biological and Medical Research annual technical report, 1981

    International Nuclear Information System (INIS)

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies

  16. Division of Biological and Medical Research annual technical report, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1982-06-01

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

  17. Technology Base Research Project for electrochemical energy storage

    Science.gov (United States)

    Kinoshita, K.

    1985-06-01

    The DOE Electrochemical Energy Storage Program is divided into two projects: (1) the exploratory technology development and testing (ETD) project and (2) the technology base research (TBR) project. The role of the TBR Project is to perform supporting research for the advanced battery systems under development by the ETD Project, and to evaluate new systems with potentially superior performance, durability and/or cost characteristics. The specific goal of the TBR Project is to identify the most promising electrochemical technologies and transfer them to industry and/or the ETD Project for further development and scale-up. This report summarizes the research, financial, and management activities relevant to the TBR Project in CY 1984. General problem areas addressed by the project include identification of new electrochemical couples for advanced batteries, determination of technical feasibility of the new couples, improvements in battery components and materials, establishment of engineering principles applicable to electrochemical energy storage and conversion, and the assessment of fuel-cell technology for transportation applications. Major emphasis is given to applied research which will lead to superior performance and lower life-cycle costs. The TBR Project is divided into three major project elements: exploratory research, applied science research, and air systems research.

  18. Division of Biological and Medical Research research summary 1984-1985

    International Nuclear Information System (INIS)

    The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group

  19. Division of Biological and Medical Research research summary 1984-1985

    Energy Technology Data Exchange (ETDEWEB)

    Barr, S.H. (ed.)

    1985-08-01

    The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group.

  20. An Effective Method to Evaluate the Scientific Research Projects

    OpenAIRE

    Hou Xiaohui; Huang Lei; Li Xuefei

    2014-01-01

    The evaluation of the scientific research projects is an important procedure before the scientific research projects are approved. The BP neural network and linear neural network are adopted to evaluate the scientific research projects in this paper. The evaluation index system with 12 indexes is set up. The basic principle of the neural network is analyzed and then the BP neural network and linear neural network models are constructed and the output error function of the neural networks is i...

  1. Considerations and Infrastructure Milestones for a Research Reactor Project

    International Nuclear Information System (INIS)

    Establishment of a research reactor is a major project requiring careful planning, preparation, implementation, and investment in time and human resources. The implementation of such a project requires establishment of sustainable infrastructures, including legal and regulatory, safety, technical, and economic. This paper discusses the scope of these infrastructures and the major stages in their development; starting with a robust pre-project justification for the research reactor and moving through three milestones in the establishment of the infrastructure itself. The paper discusses also the main elements of the feasibility study for a new research reactor project and specific safety and technical considerations in different phases of the project as well as the major activities to be performed along with the project phases, including progressive involvement of the main organizations in the project, and application of the IAEA Code of Conduct on the Safety of Research Reactors and IAEA Safety Standards. (author)

  2. Researchers' Experiences, Positive and Negative, in Integrative Landscape Projects

    Science.gov (United States)

    Tress, Bärbel; Tress, Gunther; Fry, Gary

    2005-12-01

    Integrative (interdisciplinary and transdisciplinary) landscape research projects are becoming increasingly common. As a result, researchers are spending a larger proportion of their professional careers doing integrative work, participating in shifting interdisciplinary teams, and cooperating directly with non-academic participants. Despite the growing importance of integrative research, few studies have investigated researchers’ experiences in these projects. How do researchers perceive the outcomes of integrative projects, or career effects? Do they view the projects generally as successes or failures? This study analyses researchers’ experiences in integrative landscape studies and investigates what factors shape these experiences. The data stems from 19 semi-structured qualitative interviews and a Web-based survey among 207 participants in integrative landscape research projects. It finds that researchers experience participation in integrative projects as positive, in particular discussions among participants, networking, teamwork, and gaining new insights and skills. Furthermore, most researchers perceive the projects as successful and as having a positive effect on their careers. Less positive aspects of integration relate to publications and merit points. Factors found to contribute to positive experiences include reaching a high degree of integration amongst the involved disciplines, common definitions of integrative research concepts, and projects that include a large share of fundamental research as well as projects with many project outcomes. Based on these findings, we advise future projects to plan for integration, facilitate discussions, and reach agreement on integrative concepts. We suggest that aspects of fundamental research be included in integrative projects. We also suggest that planning be done at an early stage for peer-reviewed publications, to ensure that participants gain merit points from their participation in integrative research

  3. Division of Biological and Medical Research annual technical report 1982

    International Nuclear Information System (INIS)

    This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the genetic effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies

  4. Division of Biological and Medical Research annual technical report 1982

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1983-05-01

    This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the genetic effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

  5. Linguistic analysis of project ownership for undergraduate research experiences.

    Science.gov (United States)

    Hanauer, D I; Frederick, J; Fotinakes, B; Strobel, S A

    2012-01-01

    We used computational linguistic and content analyses to explore the concept of project ownership for undergraduate research. We used linguistic analysis of student interview data to develop a quantitative methodology for assessing project ownership and applied this method to measure degrees of project ownership expressed by students in relation to different types of educational research experiences. The results of the study suggest that the design of a research experience significantly influences the degree of project ownership expressed by students when they describe those experiences. The analysis identified both positive and negative aspects of project ownership and provided a working definition for how a student experiences his or her research opportunity. These elements suggest several features that could be incorporated into an undergraduate research experience to foster a student's sense of project ownership.

  6. Project management success in health : the need of additional research in public health projects

    OpenAIRE

    Santos, Carolina; Santos, Vitor; Tavares, António J.; Varajão, João

    2014-01-01

    PROJMAN 2014 - International Conference on Project MANagement, Procedia Technology The research about the factors that are linked to project management performance and project management success, has been developed for several years, so the literature about this subject is relatively extensive. After a literature review about project success factors, it was found that the current research effort is mainly focused on information technology, engineering and software development proj...

  7. Life lines: An art history of biological research around 1800.

    Science.gov (United States)

    Bruhn, Matthias

    2011-12-01

    Around 1800, the scientific "illustrator" emerged as a new artistic profession in Europe. Artists were increasingly sought after in order to picture anatomical dissections and microscopic observations and to translate drawings into artworks for books and journals. By training and technical expertise, they introduced a particular kind of knowledge into scientific perception that also shaped the common image of nature. Illustrations of scientific publications, often undervalued as a biased interpretation of facts and subordinate to logic and description, thus convey an 'art history' of science in its own right, relevant both for the understanding of biological thought around 1800 as well as for the development of the arts and their historiography. The article is based on an analysis of botanical treatises produced for the Göttingen Society of Sciences in 1803, during an early phase of microscopic cell research, in order to determine the constitutive role of artistic knowledge and the media employed for the visualization and conceptualization of biological issues.

  8. Systems biology and bioinformatics in aging research: a workshop report.

    Science.gov (United States)

    Fuellen, Georg; Dengjel, Jörn; Hoeflich, Andreas; Hoeijemakers, Jan; Kestler, Hans A; Kowald, Axel; Priebe, Steffen; Rebholz-Schuhmann, Dietrich; Schmeck, Bernd; Schmitz, Ulf; Stolzing, Alexandra; Sühnel, Jürgen; Wuttke, Daniel; Vera, Julio

    2012-12-01

    In an "aging society," health span extension is most important. As in 2010, talks in this series of meetings in Rostock-Warnemünde demonstrated that aging is an apparently very complex process, where computational work is most useful for gaining insights and to find interventions that counter aging and prevent or counteract aging-related diseases. The specific topics of this year's meeting entitled, "RoSyBA: Rostock Symposium on Systems Biology and Bioinformatics in Ageing Research," were primarily related to "Cancer and Aging" and also had a focus on work funded by the German Federal Ministry of Education and Research (BMBF). The next meeting in the series, scheduled for September 20-21, 2013, will focus on the use of ontologies for computational research into aging, stem cells, and cancer. Promoting knowledge formalization is also at the core of the set of proposed action items concluding this report.

  9. SETAC launches global horizon scanning/research prioritization project

    Science.gov (United States)

    The SETAC World Council is pleased to announce the initiation of a Global Horizon Scanning and Prioritization Project aimed at identifying geographically specific research needs to address stressor impacts on environmental quality. In recent years, horizon scanning and research ...

  10. Researchers' experiences, positive and negative, in integrative landscape projects

    NARCIS (Netherlands)

    Tress, B.; Tress, G.; Fry, G.

    2005-01-01

    Integrative (interdisciplinary and transdisciplinary) landscape research projects are becoming increasingly common. As a result, researchers are spending a larger proportion of their professional careers doing integrative work, participating in shifting interdisciplinary teams, and cooperating direc

  11. Ten steps to success in integrative research projects

    NARCIS (Netherlands)

    Tress, B.; Tress, G.; Fry, G.

    2006-01-01

    Research in the INTELS project has revealed that many integrative (= interdisciplinary and transdisciplinary) landscape projects frequently face similar challenges. There are, however, few guidelines available to help projects avoid common problems. In this chapter, we present what we consider the t

  12. CAS conducts ex-post evaluation on research projects

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Under the auspices of the CAS Center for Project Supervision and Evaluation, a panel of experts recently conducted an ex-post evaluation on a research project entitled "the electrical system for an electric vehicle." The appraisal is the first of its kind in project management at CAS.

  13. Explorations: A Research-Based Program Introducing Undergraduates to Diverse Biology Research Topics Taught by Grad Students and Postdocs

    Science.gov (United States)

    Brownell, Sara E.; Khalfan, Waheeda; Bergmann, Dominique; Simoni, Robert

    2013-01-01

    Undergraduate biology majors are often overwhelmed by and underinformed about the diversity and complexity of biological research that is conducted on research-intensive campuses. We present a program that introduces undergraduates to the diversity and scope of biological research and also provides unique teaching opportunities for graduate…

  14. Impact of Interdisciplinary Undergraduate Research in Mathematics and Biology on the Development of a New Course Integrating Five STEM Disciplines

    Science.gov (United States)

    Caudill, Lester; Hill, April; Hoke, Kathy; Lipan, Ovidiu

    2010-01-01

    Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was…

  15. Xenopus laevis a success story of biological research in space

    Science.gov (United States)

    Horn, Eberhard R.

    2006-01-01

    The clawed toad Xenopus laevis is a common experimental animal used in many disciplines of life sciences, such as integrative, developmental and molecular biology or experimental medicine. Since 30 years, Xenopus is used in biological research in space. Important milestones were the years 1975, when Xenopus embryos flew for the first time on the Russian space station Salut-4 and 1994, when Xenopus eggs were successfully fertilized for the first time in space during the Japanese Spacelab mission STS-47 and developed in microgravity to vital tadpoles. Most Xenopus studies were related to embryogenesis and development. Observations during and after altered gravity revealed changes such as the thickening of the blastocoel roof, the dorsalization of the tail, and modifications of vestibular reflexes, fictive and freely swimming. Many changes were reversible even during microgravity exposure. Studies about the vestibuloocular reflex or synapse formation revealed an age-related sensitivity to altered gravity. Xenopus offers useful tools for studies about microgravity effects on living systems. Its oocyte is a suitable model to study ion channel function in space; the dorsalization model can be used to analyse growth factor sensibilities. Hardware for life support of adults, tadpoles and embryos (cf. SUPPLY unit in combination with miniaquaria) as well as for controlled experiments in space are prerequisites for an extension of research with Xenopus. The application aspect is based on the fact that fundamental research per se brings benefit to man.

  16. International Fusion Energy Research Centre (IFERC) project

    International Nuclear Information System (INIS)

    The IFERC project is planned to encourage the ITER tokamak project and the fusion demonstration reactor development. In the project, coordination on the design and R and D of the DEMO fusion reactor, fusion reactor simulations and ITER remote experiments are being conducted at JAEA Aomori R and D site. In the present paper, broader approach activities toward realization of fusion power plants such as conceptual design of the DEMO reactor, R and D of fusion materials, testing of fusion reactor components and systems and preparation for the ITER remote experiment are reviewed. (author)

  17. Distributed Research Project Scheduling Based on Multi-Agent Methods

    Directory of Open Access Journals (Sweden)

    Constanta Nicoleta Bodea

    2011-01-01

    Full Text Available Different project planning and scheduling approaches have been developed. The Operational Research (OR provides two major planning techniques: CPM (Critical Path Method and PERT (Program Evaluation and Review Technique. Due to projects complexity and difficulty to use classical methods, new approaches were developed. Artificial Intelligence (AI initially promoted the automatic planner concept, but model-based planning and scheduling methods emerged later on. The paper adresses the project scheduling optimization problem, when projects are seen as Complex Adaptive Systems (CAS. Taken into consideration two different approaches for project scheduling optimization: TCPSP (Time- Constrained Project Scheduling and RCPSP (Resource-Constrained Project Scheduling, the paper focuses on a multiagent implementation in MATLAB for TCSP. Using the research project as a case study, the paper includes a comparison between two multi-agent methods: Genetic Algorithm (GA and Ant Colony Algorithm (ACO.

  18. The potential use of online tools for scientific collaboration by biology researchers

    OpenAIRE

    Bracken, Fintan; Earls, Daniel; Madders, Catherine; O'Leary, Faye; Ronan, Stephanie; Ward, Ciara; Tolan, Paul; Wusteman, Judith

    2014-01-01

    Purpose - The purpose of this paper is to discover the research practices of biology researchers and to assess the suitability of the OJAX++ Virtual Research Environment (VRE) for these researchers. Design/methodology/approach â Usability testing was used to evaluate the usability of OJAX++ in relation to biology researchers. Interviews with biology researchers in a large Irish university were conducted to investigate their research information behaviour, to establish user requirements ...

  19. Defining and implementing a model for pharmacy resident research projects

    Directory of Open Access Journals (Sweden)

    Dick TB

    2015-09-01

    Full Text Available Objective: To describe a standard approach to provide a support structure for pharmacy resident research that emphasizes self-identification of a residency research project. Methods: A subcommittee of the residency advisory committee was formed at our institution. The committee was initially comprised of 2 clinical pharmacy specialists, 1 drug information pharmacist, and 2 pharmacy administrators. The committee developed research guidelines that are distributed to residents prior to the residency start that detail the research process, important deadlines, and available resources. Instructions for institutional review board (IRB training and deadlines for various assignments and presentations throughout the residency year are clearly defined. Residents conceive their own research project and emphasis is placed on completing assignments early in the residency year. Results: In the 4 years this research process has been in place, 15 of 16 (94% residents successfully identified their own research question. All 15 residents submitted a complete research protocol to the IRB by the August deadline. Four residents have presented the results of their research at multi-disciplinary national professional meetings and 1 has published a manuscript. Feedback from outgoing residents has been positive overall and their perceptions of their research projects and the process are positive. Conclusion: Pharmacy residents selecting their own research projects for their residency year is a feasible alternative to assigning or providing lists of research projects from which to select a project.

  20. A Natural Gas Field Research Project Passed Acceptance

    Institute of Scientific and Technical Information of China (English)

    Liang Hongguang; Wang Weiyuan

    1996-01-01

    @@ Based on the fact that all sub-topics had passed acceptance and appraised, a research project entitled "The study on formation condition, distribution and exploration technology of large and medium sized natural gas field (project No. 85-102)" was finally accepted and appraised by State Planning Commission on January 11, 1996. The research project is a state key scientific research project in the "Eighth Five-Year Plan" jointly undertaken by CNPC,Ministry of Geology and Mineral Resources of the P.R.C.,CNOOC and Chinese Academy of Sciences (CAS).

  1. Annual review of research projects 1980

    International Nuclear Information System (INIS)

    The Australian Radiation Laboratory is a national centre concerned with the public and occupational health aspects of the use of both ionising and non-ionising radiation. Thirty two projects which were in progress during 1980 are described

  2. Teachers' Learning in a Research and Development Work Project

    Science.gov (United States)

    Postholm, May Britt

    2011-01-01

    This article focuses on teachers' learning in a research and development (R&D) work project. The teachers are working in a lower secondary school, and the cooperation between them and the researcher lasted for two years. The aim of this article is to show what teachers can learn and how they can learn during such a project. In the qualitative…

  3. Geothermal project summaries. Geothermal energy research, development and demonstration program

    Energy Technology Data Exchange (ETDEWEB)

    1976-09-01

    Summaries of all Division of Geothermal Energy supported projects for which contracts have been executed are compiled. Each summary includes pertinent statistical data for that project and an abstract summarizing the project plans and accomplishments. The projects summarized fall into six categories: engineering research and development, resource exploration and assessment, hydrothermal technology applications, advanced technology applications, utilization experiments, and environmental control and institutional studies. (MHR)

  4. Global Relevance of Translational Research in Engineering and Project Management

    Directory of Open Access Journals (Sweden)

    Kriengsak Panuwatwanich

    2016-07-01

    Full Text Available In this issue of the EPPM journal, we include five interesting papers reporting on the research undertaken within the contexts of five different countries: Italy, Norway, Saudi Arabia, Romania and Iran. These papers address various key issues in engineering and project management, including green building rating system, agile project management, construction delays, awarding process of public construction projects and Building Information Modelling (BIM. A good mixture of both quantitative and qualitative research methods is also worth noting in this issue.

  5. Caenorhabditis elegans, a Biological Model for Research in Toxicology.

    Science.gov (United States)

    Tejeda-Benitez, Lesly; Olivero-Verbel, Jesus

    2016-01-01

    Caenorhabditis elegans is a nematode of microscopic size which, due to its biological characteristics, has been used since the 1970s as a model for research in molecular biology, medicine, pharmacology, and toxicology. It was the first animal whose genome was completely sequenced and has played a key role in the understanding of apoptosis and RNA interference. The transparency of its body, short lifespan, ability to self-fertilize and ease of culture are advantages that make it ideal as a model in toxicology. Due to the fact that some of its biochemical pathways are similar to those of humans, it has been employed in research in several fields. C. elegans' use as a biological model in environmental toxicological assessments allows the determination of multiple endpoints. Some of these utilize the effects on the biological functions of the nematode and others use molecular markers. Endpoints such as lethality, growth, reproduction, and locomotion are the most studied, and usually employ the wild type Bristol N2 strain. Other endpoints use reporter genes, such as green fluorescence protein, driven by regulatory sequences from other genes related to different mechanisms of toxicity, such as heat shock, oxidative stress, CYP system, and metallothioneins among others, allowing the study of gene expression in a manner both rapid and easy. These transgenic strains of C. elegans represent a powerful tool to assess toxicity pathways for mixtures and environmental samples, and their numbers are growing in diversity and selectivity. However, other molecular biology techniques, including DNA microarrays and MicroRNAs have been explored to assess the effects of different toxicants and samples. C. elegans has allowed the assessment of neurotoxic effects for heavy metals and pesticides, among those more frequently studied, as the nematode has a very well defined nervous system. More recently, nanoparticles are emergent pollutants whose toxicity can be explored using this nematode

  6. Construction of an 8-mm time-lapse camera for biological research

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This report covers the construction of an 8mm camera for biological research. A time-lapse camera for use in biological research can be constructed from a super...

  7. A framework for integrating thermal biology into fragmentation research.

    Science.gov (United States)

    Tuff, K T; Tuff, T; Davies, K F

    2016-04-01

    Habitat fragmentation changes thermal conditions in remnant patches, and thermal conditions strongly influence organism morphology, distribution, and activity patterns. However, few studies explore temperature as a mechanism driving ecological responses to fragmentation. Here we offer a conceptual framework that integrates thermal biology into fragmentation research to better understand individual, species, community, and ecosystem-level responses to fragmentation. Specifically, the framework addresses how fragmentation changes temperature and how the effects of those temperature changes spread through the ecosystem, from organism response via thermal sensitivity, to changes in species distribution and activity patterns, to shifts in community structure following species' responses, and ultimately to changes in ecosystem functions. We place a strong emphasis on future research directions by outlining "Critical gaps" for each step of the framework. Empirical efforts to apply and test this framework promise new understanding of fragmentation's ecological consequences and new strategies for conservation in an increasingly fragmented and warmer world. PMID:26892491

  8. 2010 Tetrapyrroles, Chemistry & Biology of Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Angela Wilks

    2010-07-30

    The objective of the Chemistry & Biology of Tetrapyrroles Gordon Conference is to bring together researchers from diverse disciplines that otherwise would not interact. By bringing biologists, chemists, engineers and clinicians with a common interest in tetrapyrroles the conference provides a forum for cross-disciplinary ideas and collaboration. The perspective provided by biologists, chemists, and clinicians working in fields such as newly discovered defects in human porphyrin metabolism, the myriad of strategies for light harvesting in photosynthetic organisms, novel tetrapyrroles that serve as auxiliary chromophores or enzyme cofactors, synthetic strategies in the design of novel tetrapyrrole scaffolds, and tetrapyrrole based cell signaling and regulatory systems, makes this conference unique in the field. Over the years the growing evidence for the role of tetrapyrroles and their reactive intermediates in cell signaling and regulation has been of increasing importance at this conference. The 2010 conference on Chemistry & Biology of Tetrapyrroles will focus on many of these new frontiers as outlined in the preliminary program listed. Speakers will emphasize unpublished results and new findings in the field. The oral sessions will be followed by the highly interactive afternoon poster sessions. The poster sessions provide all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, this opportunity will continue during the nightly social gathering that takes place in the poster hall following the evening lectures. All conferees are encouraged to submit and present posters. At the conference the best poster in the areas of biology, chemistry and medicine will be selected by a panel of previous conference chairs.

  9. Methods of 15N tracer research in biological systems

    International Nuclear Information System (INIS)

    The application of the stable isotope 15N is of increasing importance in different scientific disciplines, especially in medicine, agriculture, and the biosciences. The close correlation between the growing interest and improvements of analytical procedures resulted in remarkable advances in the 15N tracer technique. On the basis of the latest results of 15N tracer research in life sciences and agriculture methods of 15N tracer research in biological systems are compiled. The 15N methodology is considered under three headings: Chemical analysis with a description of methods of sample preparation (including different separation and isolation methods for N-containing substances of biological and agricultural origin) and special procedures converting ammonia to molecular nitrogen. Isotopic analysis with a review on the most important methods of isotopic analysis of nitrogen: mass spectrometry (including the GC-MS technique), emission spectrometry, NMR spectroscopy, and other analytical procedures. 15N-tracer techniques with a consideration of the role of the isotope dilution analysis as well as different labelling techniques and the mathematical interpretation of tracer data (modelling, N turnover experiments). In these chapters also sources of errors in chemical and isotopic analysis, the accuracy of the different methods and its importance on tracer experiments are discussed. Procedures for micro scale 15N analysis and aspects of 15N analysis on the level of natural abundance are considered. Furthermore some remarks on isotope effects in 15N tracer experiments are made. (author)

  10. Global biology - An interdisciplinary scientific research program at NASA, Ames Research Center

    Science.gov (United States)

    Lawless, J. G.; Colin, L.

    1983-01-01

    NASA has initiated new effort in Global Biology, the primary focus of which is to understand biogeochemical cycles. As part of this effort, an interdisciplinary team of scientists has formed at Ames Research Center to investigate the cycling of sulfur in the marine coastal zone and to study the cycling of nitrogen in terrestrial ecosystems. Both studies will use remotely sensed data, coupled with ground-based research, to identify and measure the transfer of major and minor biologically produced gases between these ecosystems and global reservoirs.

  11. Global Biology: An Interdisciplinary Scientific Research Program at NASA Ames Research Center

    Science.gov (United States)

    Lawless, James G.; Colin, Lawrence

    1984-01-01

    NASA has initiated new effort in Global Biology, the primary focus of which is to understand biogeochemical cycles. As part of this effort, an interdisciplinary team of scientists has formed at Ames Research Center to investigate the cycling of sulfur in the marine coastal zone and to study the cycling of nitrogen in terrestrial ecosystems. Both studies will use remotely sensed data, coupled with ground-based research, to identify and measure the transfer of major and minor biologically produced gases between these ecosystems and global reservoirs.

  12. "Biology Education"--An Emerging Interdisciplinary Area of Research

    Science.gov (United States)

    Rutledge, Michael

    2013-01-01

    The growing number of faculty positions in biology education, the formation of professional societies focused specifically on biology education, and the increasing number of publications in biology education over the past decade

  13. What research project management in Earth sciences really means

    Science.gov (United States)

    Cristini, Luisa; Lampitt, Richard; Alexiou, Sofia

    2015-04-01

    Since much earlier than at the start of a research project, principal investigators and project coordinators have responsibilities that go far beyond their scientific interests. Management and communication skills are essential to build those working relationships that will result in a successful proposal as well as to disseminate project outputs to the funding agencies and the public sector. Starting from the cases of the FixO3 project and the previous EuroSITES, two EU-funded collaborative projects in observational oceanography, we show practical examples of typical management issues in research projects from the initial phase of outlining and submitting a proposal to the project implementation and reporting of the results.

  14. Philosophy of biology: outline of a transcendental project.

    Science.gov (United States)

    Van de Vijver, Gertrudis; Van Speybroeck, Linda; De Waele, Dani; Kolen, Filip; De Preester, Helena

    2005-01-01

    This paper analyses the actual meaning of a transcendental philosophy of biology, and does so by exploring and actualising the epistemological and metaphysical value of Kant's viewpoint on living systems. It finds inspiration in the Kantian idea of living systems intrinsically resisting objectification, but critically departs from Kant's philosophical solution in as far as it is based in a subjectivist dogmatism. It attempts to overcome this dogmatism, on the one hand by explicitly taking into account the conditions of possibility at the side of the subject, and on the other hand by embedding both the living and the knowing system into an ontology of complexly organized dynamical systems. This paper fits into the transcendental perspective in acknowledging the need to analyse the conditions of knowability, prior to the contents of what is known. But it also contributes to an expansion and an actualisation of the issue of transcendentality itself by considering the conditions of possibility at the side of the object as intrinsically linked to the conditions of possibility at the side of the subject. PMID:16049729

  15. Scientific projection paper on biologic effects of ionizing radiation

    International Nuclear Information System (INIS)

    There is widespread knowledge about the effects of radiation in human populations but the studies have had some limitations which have left gaps in our knowledge. Most populations have had exposure to high doses with little information on the effect of dose rate. The characteristics of the populations have been restricted by the location of the disaster, the occupational limitations, or the basic risks associated with the under-lying disease for which radiation was given. All doses have been estimated and such values are subject to marked variability particularly when they rely on sources of data such as hospital records. The biological data although extensive have several deficits in information. Which are the sites in which cancer is produced by irradiation and what are the cell types which are produced. The sensitivity of various tissues and organs are not similar and it is important to rank them according to susceptibility. This has been done in the past but the results are not complete for all cell types and organs. The temporal patterns for tumor development, the latent period, the period of expressed excess, the life-time risks need to be defined more precisely for the cancers. Many populations have not been followed long enough to express the complete risk

  16. Otaniemi PFBC/G testing and research project

    Energy Technology Data Exchange (ETDEWEB)

    Hulkkonen, S.; Jahkola, A.; Kurkela, E.; Korhonen, M.

    1988-01-01

    The research project /sup E/xperimental Research of Pressurized Fluidized Bed Technology and its Application to Combined and Heat Generation/sup /was started in 1986. The project is carried out in co-operation between Helsinki University of Technology (TKK), Technical Research Centre of Finland (VTT) and Imatran Voima (IVO). The project is scheduled for year 1986-1989 and is mainly financed by the Ministry of Trade and Industry (KTM). The total costs of the project are 10 million FIM including the test facilities. The objective of the project is to create knowledge of the basics of pressurized fluidized bed combustion/gasification and their applications. The fuel of main interest is peat. The research is realized partly theoretically based on literature studies and computer runs but primarily by experimental measurements carried out using the PFBC/G test rig.

  17. Division of Biological and Medical Research annual report, 1980

    International Nuclear Information System (INIS)

    The research during 1980 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Research related to nuclear energy includes the delineation, in the beagle, of the responses to continuous low level 60Co gamma radiation and the development of cellular indicators of preclinical phases of leukemia; comparison of lifetime effects in mice of low level neutron and 60Co gamma radiation; studies of the genetic effects of high LET radiations; and studies of the gastrointestinal absorption of the actinide elements. Research related to nonuclear energy sources deals with characterization and toxicological evaluation of process streams and effluents of coal gasification; with electrical storage systems; and electric fields associated with energy transmission. Proteins in human urine and selected tissues are examined by two-dimensional electrophoresis to detect disease and pollutant related changes. Assessment of human risk associated with nuclearing collective dose commitment will result in more attention being paid to potential releases of radionuclides at relatively short times after disposal

  18. Research Projects and Undergraduate Retention at the University of Arizona

    Science.gov (United States)

    Walker-LaFollette, Amanda; Hardegree-Ullman, K.; Towner, A. P.; McGraw, A. M.; Biddle, L. I.; Robertson, A.; Turner, J.; Smith, C.

    2013-06-01

    The University of Arizona’s Astronomy Club utilizes its access to the many telescopes in and around Tucson, Arizona, to allow students to fully participate in a variety of research projects. Three current projects - the exoplanet project, the radio astronomy project, and the Kepler project - all work to give undergraduates who are interested in astronomy the opportunity to explore practical astronomy outside the classroom and in a peer-supported environment. The exoplanet project strives to teach students about the research process, including observing exoplanet transits on the Steward Observatory 61” Kuiper telescope on Mt. Bigelow in Tucson, AZ, reducing the data into lightcurves with the Image Reduction and Analysis Facility (IRAF), modeling the lightcurves using the Interactive Data Language (IDL), and writing and publishing a professional paper, and does it all with no faculty involvement. The radio astronomy project is designed to provide students with an opportunity to work with a professor on a radio astronomy research project, and to learn about the research process, including observing molecules in molecular clouds using the Arizona Radio Observatory 12-meter radio telescope on Kitt Peak in Arizona. The Kepler project is a new project designed in part to facilitate graduate-undergraduate interaction in the Astronomy Department, and in part to allow students (both graduate and undergraduate) to participate in star-spot cycle research using data from the Kepler Mission. All of these research projects and structures provide students with unique access to telescopes, peer mentoring, networking, and understanding the entire process of astronomical research.

  19. A ProCoS II Project Final Report: ESPRIT Basic Research project 707

    DEFF Research Database (Denmark)

    Bowen, J. P.; Hoare, C. A. R.; Langmaack, Hans;

    1996-01-01

    An overview of the research and associated activities of the Europeancollaborative ESPRIT Basic Research ProCoS II project (no. 7071) on``Provably Correct Systems'' which ran from 1992 to 1995 is presented.This was a follow-on project to ProCoS (no. 3104) and ran inparallel with the ProCoS Working...

  20. Ethics in Project Management Research on Values-Based Leadership in Project Driven Arenas

    OpenAIRE

    Walker, Loran; A Moylan, William

    2014-01-01

    The paper addresses the values-based leadership skills, values and concepts of ethical project management professionals, and, considers the applicability of this leadership construct to the processes of managing major projects in different industries and applications. The purpose of the research study is to determine the suitability of a values-based leadership approach for leading project teams, with a focus on improving the partnerships within industrial programs. The main research question...

  1. Impact of Interdisciplinary Undergraduate Research in Mathematics and Biology on the Development of a New Course Integrating Five STEM Disciplines

    OpenAIRE

    Caudill, Lester; Hill, April; Hoke, Kathy; Lipan, Ovidiu

    2010-01-01

    Funded by innovative programs at the National Science Foundation and the Howard Hughes Medical Institute, University of Richmond faculty in biology, chemistry, mathematics, physics, and computer science teamed up to offer first- and second-year students the opportunity to contribute to vibrant, interdisciplinary research projects. The result was not only good science but also good science that motivated and informed course development. Here, we describe four recent undergraduate research proj...

  2. Systems Biology - A Pivotal Research Methodology for Understanding the Mechanisms of Traditional Medicine

    OpenAIRE

    Soojin Lee

    2015-01-01

    Objectives: Systems biology is a novel subject in the field of life science that aims at a systems’ level understanding of biological systems. Because of the significant progress in high-throughput technologies and molecular biology, systems biology occupies an important place in research during the post-genome era. Methods: The characteristics of systems biology and its applicability to traditional medicine research have been discussed from three points of view: data and databases, network a...

  3. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    Energy Technology Data Exchange (ETDEWEB)

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  4. Scientific research projects in vocational training schools

    OpenAIRE

    Esteves, Zita; Manuel F. M. Costa

    2010-01-01

    Vocational schools are a resource for many students, with usually low motivation and high learning difficulties. The fact that this type of teaching is of a more practical, experimental, and job oriented type, points to teaching strategies less theoretical and focus on a more practical student involvement. Profiting from those characteristics, the study of the use of scientific projects on vocational teaching was initiated. It was proposed to vocational school st...

  5. Growth Analysis of Cancer Biology Research, 2000-2011

    Directory of Open Access Journals (Sweden)

    Keshava,

    2015-09-01

    Full Text Available Methods and Material: The PubMed database was used for retrieving data on 'cancer biology.' Articles were downloaded from the years 2000 to 2011. The articles were classified chronologically and transferred to a spreadsheet application for analysis of the data as per the objectives of the study. Statistical Method: To investigate the nature of growth of articles via exponential, linear, and logistics tests. Result: The year wise analysis of the growth of articles output shows that for the years 2000 to 2005 and later there is a sudden increase in output, during the years 2006 to 2007 and 2008 to 2011. The high productivity of articles during these years may be due to their significance in cancer biology literature, having received prominence in research. Conclusion: There is an obvious need for better compilations of statistics on numbers of publications in the years from 2000 to 2011 on various disciplines on a worldwide scale, for informed critical assessments of the amount of new knowledge contributed by these publications, and for enhancements and refinements of present Scientometric techniques (citation and publication counts, so that valid measures of knowledge growth may be obtained. Only then will Scientometrics be able to provide accurate, useful descriptions and predictions of knowledge growth.

  6. 7 CFR 932.45 - Production research and marketing research and development projects.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Production research and marketing research and....45 Production research and marketing research and development projects. (a) The following activities... Secretary, establish or provide for the establishment of production research, and marketing research...

  7. Nuclear physics detector technology applied to plant biology research

    Energy Technology Data Exchange (ETDEWEB)

    Weisenberger, A.G., E-mail: drew@jlab.org [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Kross, B.; Lee, S.J.; McKisson, J.; McKisson, J.E.; Xi, W.; Zorn, C. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Howell, C.R.; Crowell, A.S. [Duke University, Durham, NC (United States); Triangle Universities Nuclear Laboratory, Durham, NC (United States); Reid, C.D. [Duke University, Durham, NC (United States); Smith, M. [University of Maryland, Baltimore, MD (United States)

    2013-08-01

    The ability to detect the emissions of radioactive isotopes through radioactive decay (e.g. beta particles, x-rays and gamma-rays) has been used for over 80 years as a tracer method for studying natural phenomena. More recently a positron emitting radioisotope of carbon: {sup 11}C has been utilized as a {sup 11}CO{sub 2} tracer for plant ecophysiology research. Because of its ease of incorporation into the plant via photosynthesis, the {sup 11}CO{sub 2} radiotracer is a powerful tool for use in plant biology research. Positron emission tomography (PET) imaging has been used to study carbon transport in live plants using {sup 11}CO{sub 2}. Presently there are several groups developing and using new PET instrumentation for plant based studies. Thomas Jefferson National Accelerator Facility (Jefferson Lab) in collaboration with the Duke University Phytotron and the Triangle Universities Nuclear Laboratory (TUNL) is involved in PET detector development for plant imaging utilizing technologies developed for nuclear physics research. The latest developments of the use of a LYSO scintillator based PET detector system for {sup 11}CO{sub 2} tracer studies in plants will be briefly outlined.

  8. Constructing failure in big biology: The socio-technical anatomy of Japan's Protein 3000 Project.

    Science.gov (United States)

    Fukushima, Masato

    2016-02-01

    This study focuses on the 5-year Protein 3000 Project launched in 2002, the largest biological project in Japan. The project aimed to overcome Japan's alleged failure to contribute fully to the Human Genome Project, by determining 3000 protein structures, 30 percent of the global target. Despite its achievement of this goal, the project was fiercely criticized in various sectors of society and was often branded an awkward failure. This article tries to solve the mystery of why such failure discourse was prevalent. Three explanatory factors are offered: first, because some goals were excluded during project development, there was a dynamic of failed expectations; second, structural genomics, while promoting collaboration with the international community, became an 'anti-boundary object', only the absence of which bound heterogeneous domestic actors; third, there developed an urgent sense of international competition in order to obtain patents on such structural information.

  9. Speaking up about Advocacy: Findings from a Partnership Research Project

    Science.gov (United States)

    Chapman, Melanie; Bannister, Susan; Davies, Julie; Fleming, Simon; Graham, Claire; Mcmaster, Andrea; Seddon, Angela; Wheldon, Anita; Whittell, Bridget

    2012-01-01

    This article describes a partnership research project carried out by a research team consisting of people with learning disabilities and people without learning disabilities. The research explored people's understandings of advocacy and identified gaps in advocacy provision for people with learning disabilities and their families. Four focus…

  10. Biomining of regolith simulants for biological in situ resource utilization Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of this proposed research is to advance the development of biological in situ resource utilization for NASA's space exploration programs. We plan to build...

  11. Technology under Planetary Protection Research (PPR) Project

    Data.gov (United States)

    National Aeronautics and Space Administration — PPR supports research to improve NASA's understanding of the potential for both forward and backward contamination, how to minimize it, and to set standards in...

  12. MODEL ORGANISMS USED IN MOLECULAR BIOLOGY OR MEDICAL RESEARCH

    Directory of Open Access Journals (Sweden)

    Pandey Govind

    2011-11-01

    Full Text Available A model organism is a non-human species that is studied to understand specific biological phenomena with the expectation that investigations made in the organism model will provide insight into the workings of other organisms. The model organisms are widely used to explore potential causes and treatments for human as well as animal diseases when experiments on animals or humans would be unfeasible or considered less ethical. Studying model organisms may be informative, but care must be taken when generalizing from one organism to another. Often, model organisms are chosen on the basis that they are amenable to experimental manipulation. When researchers look for an organism to use in their studies, they look for several traits. Among these are size, generation time, accessibility, manipulation, genetics, conservation of mechanisms and potential economic benefit. As comparative molecular biology has become more common, some researchers have sought model organisms from a wider assortment of lineages on the tree of life. There are many model organisms, such as viruses (e.g., Phage lambda virus, Tobacco mosaic virus, etc., bacteria (e.g., Bacillus subtilis, Escherichia coli, Pseudomonas fluorescens, Vibrio fischeri, etc., algae (e.g., Chlamydomonas reinhardtii, Emiliania huxleyi, etc., molds (e.g., Aspergillus nidulans, Neurospora crassa, etc., yeasts (e.g., Saccharomyces cerevisiae, Ustilago maydis, etc., higher plants (e.g., Arabidopsis thaliana, Lemna gibba, Lotus japonicus, Nicotiana tabaccum, Oryza sativa, Physcomitrella patens, Zea mays, etc. and animals (e.g., Caenorhabditis elegans, guinea pig, hamster, mouse, rat, cat, chicken, dog, frog, Hydra, Drosophila melanogaster fruit fly, fish, etc..

  13. Budgeting, funding, and managing clinical research projects.

    Science.gov (United States)

    Hatfield, Elizabeth; Dicks, Elizabeth; Parfrey, Patrick

    2009-01-01

    Large, integrated multidisciplinary teams have become recognized as an efficient means by which to drive innovation and discovery in clinical research. This chapter describes how to budget and fund these large studies and effectively manage the large, often dispersed teams involved. Sources of funding are identified; budget development, justification, reporting, financial governance, and accountability are described; in addition to the creation and management of the multidisciplinary team that will implement the research plan. PMID:19160746

  14. The IT project manager competencies that impact project success – A qualitative research

    Directory of Open Access Journals (Sweden)

    Cíntia Cristina Silva de Araújo

    2015-07-01

    Full Text Available Since there is a lack of studies about the relationship of IT project manager competencies and project success, this paper will address the following research question: Which competencies should IT project managers develop in order to achieve success in IT projects? To answer this question, we conducted a qualitative research with an exploratory approach. To collect data, twelve (12 in-depth interviews were done with Brazilian project managers from different companies from several business sectors. The analysis results pointed out that for our respondents the most needed category of competencies are team management, business domain knowledge,  communication, project management and people skills. As other authors have affirmed, technical skills were considered to be less relevant to project success than interpersonal and intrapersonal competencies.

  15. Research project grouping and ranking by using adaptive Mahalanobis clustering

    OpenAIRE

    Zeljko Turkalj; Damir Markulak; Slavica Singer; Rudolf Scitovski

    2016-01-01

    The paper discusses the problem of grouping and ranking of research projects submitted for a call. The projects are grouped into clusters based on the assessment obtained in the review procedure and by using the adaptive Mahalanobis clustering method as a special case of the Expectation Maximization algorithm. The cluster of projects assessed as best is specially analyzed and ranked. The paper outlines several possibilities for the use of data obtained in the review procedure, and the propose...

  16. Optimal Sequencing and Resource Allocation in Research and Development Projects

    OpenAIRE

    Daniel Granot; Dror Zuckerman

    1991-01-01

    The main purpose of this study is to construct a suitable research and development (R&D) model which would facilitate the analysis of activity sequencing and resource allocation in R&D projects. In the proposed model, essential characteristics of R&D projects are incorporated. Namely, the activities and the technological specifications of the project are selected dynamically, and the stopping time of the R&D process is introduced as a decision variable to be determined endogeneously. We chara...

  17. Project scheduling under uncertainty: survey and research potentials.

    OpenAIRE

    Herroelen, Willy; Leus, Roel

    2005-01-01

    The vast majority of the research efforts in project scheduling assume complete information about the scheduling problem to be solved and a static deterministic environment within which the pre-computed baseline schedule will be executed. However, in the real world, project activities are subject to considerable uncertainty, which is gradually resolved during project execution. In this survey we review the fundamental approaches for scheduling under uncertainty: reactive scheduling, stochasti...

  18. Project scheduling under undertainty – survey and research potentials.

    OpenAIRE

    Herroelen, Willy; Leus, Roel

    2002-01-01

    The vast majority of the research efforts in project scheduling assume complete information about the scheduling problem to be solved and a static deterministic environment within which the pre-computed baseline schedule will be executed. However, in the real world, project activities are subject to considerable uncertainty, that is gradually resolved during project execution. In this survey we review the fundamental approaches for scheduling under uncertainty: reactive scheduling, stochastic...

  19. STRUCTURAL BIOLOGY AND MOLECULAR MEDICINE RESEARCH PROGRAM (LSBMM)

    International Nuclear Information System (INIS)

    The UCLA-DOE Institute of Genomics and Proteomics is an organized research unit of the University of California, sponsored by the Department of Energy through the mechanism of a Cooperative Agreement. Today the Institute consists of 10 Principal Investigators and 7 Associate Members, developing and applying technologies to promote the biological and environmental missions of the Department of Energy, and 5 Core Technology Centers to sustain this work. The focus is on understanding genomes, pathways and molecular machines in organisms of interest to DOE, with special emphasis on developing enabling technologies. Since it was founded in 1947, the UCLA-DOE Institute has adapted its mission to the research needs of DOE and its progenitor agencies as these research needs have changed. The Institute started as the AEC Laboratory of Nuclear Medicine, directed by Stafford Warren, who later became the founding Dean of the UCLA School of Medicine. In this sense, the entire UCLA medical center grew out of the precursor of our Institute. In 1963, the mission of the Institute was expanded into environmental studies by Director Ray Lunt. I became the third director in 1993, and in close consultation with David Galas and John Wooley of DOE, shifted the mission of the Institute towards genomics and proteomics. Since 1993, the Principal Investigators and Core Technology Centers are entirely new, and the Institute has separated from its former division concerned with PET imaging. The UCLA-DOE Institute shares the space of Boyer Hall with the Molecular Biology Institute, and assumes responsibility for the operation of the main core facilities. Fig. 1 gives the organizational chart of the Institute. Some of the benefits to the public of research carried out at the UCLA-DOE Institute include the following: The development of publicly accessible, web-based databases, including the Database of Protein Interactions, and the ProLinks database of genomicly inferred protein function linkages

  20. STRUCTURAL BIOLOGY AND MOLECULAR MEDICINE RESEARCH PROGRAM (LSBMM)

    Energy Technology Data Exchange (ETDEWEB)

    Eisenberg, David S.

    2008-07-15

    The UCLA-DOE Institute of Genomics and Proteomics is an organized research unit of the University of California, sponsored by the Department of Energy through the mechanism of a Cooperative Agreement. Today the Institute consists of 10 Principal Investigators and 7 Associate Members, developing and applying technologies to promote the biological and environmental missions of the Department of Energy, and 5 Core Technology Centers to sustain this work. The focus is on understanding genomes, pathways and molecular machines in organisms of interest to DOE, with special emphasis on developing enabling technologies. Since it was founded in 1947, the UCLA-DOE Institute has adapted its mission to the research needs of DOE and its progenitor agencies as these research needs have changed. The Institute started as the AEC Laboratory of Nuclear Medicine, directed by Stafford Warren, who later became the founding Dean of the UCLA School of Medicine. In this sense, the entire UCLA medical center grew out of the precursor of our Institute. In 1963, the mission of the Institute was expanded into environmental studies by Director Ray Lunt. I became the third director in 1993, and in close consultation with David Galas and John Wooley of DOE, shifted the mission of the Institute towards genomics and proteomics. Since 1993, the Principal Investigators and Core Technology Centers are entirely new, and the Institute has separated from its former division concerned with PET imaging. The UCLA-DOE Institute shares the space of Boyer Hall with the Molecular Biology Institute, and assumes responsibility for the operation of the main core facilities. Fig. 1 gives the organizational chart of the Institute. Some of the benefits to the public of research carried out at the UCLA-DOE Institute include the following: The development of publicly accessible, web-based databases, including the Database of Protein Interactions, and the ProLinks database of genomicly inferred protein function linkages

  1. 76 FR 32971 - Proposed Priority for the Disability and Rehabilitation Research Projects and Centers Program

    Science.gov (United States)

    2011-06-07

    ... Proposed Priority for the Disability and Rehabilitation Research Projects and Centers Program AGENCY... Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program--Disability... Services proposes a priority for the Disability and Rehabilitation Research Projects and Centers...

  2. Student Voting Rights and Patterns: A Research Project.

    Science.gov (United States)

    Eshleman, Kenneth L.

    1988-01-01

    Presents five projects on student voting rights recommended for college students in U.S. government and constitutional law courses. Projects include reading the state's residency law, investigating state and local interpretation of student voting rights, researching the constitutional issues involved in voting rights, and surveying students as to…

  3. China Advanced Research Reactor Project Progress in 2012

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Tie-jun

    2012-01-01

    <正>In 2012, all the commissioning for the China Advanced Research Reactor (CARR) had been finished and the diffraction pattern had been successfully obtained on the neutron scattering spectrometer. Meanwhile, the cold neutron source project and the acceptance items of CARR project had been carrying out.

  4. Genetics as a modernization program: biological research at the Kaiser Wilhelm Institutes and the political economy of the Nazi State.

    Science.gov (United States)

    Gausemeier, Bernd

    2010-01-01

    During the Third Reich, the biological institutes of the Kaiser Wilhelm Society (KWG, Kaiser-Wilhelm-Gesellschaft) underwent a substantial reorganization and modernization. This paper discusses the development of projects in the fields of biochemical genetics, virus research, radiation genetics, and plant genetics that were initiated in those years. These cases exemplify, on the one hand, the political conditions for biological research in the Nazi state. They highlight how leading scientists advanced their projects by building close ties with politicians and science-funding organizations and companies. On the other hand, the study examines how the contents of research were shaped by, and how they contributed to, the aims and needs of the political economy of the Nazi system. This paper therefore aims not only to highlight basic aspects of scientific development under Nazism, but also to provide general insights into the structure of the Third Reich and the dynamics of its war economy.

  5. Evaluation of the Treatment of Diabetic Retinopathy A Research Project

    Science.gov (United States)

    Kupfer, Carl

    1973-01-01

    Evaluated is the treatment of diabetic retinopathy (blindness due to ruptured vessels of the retina as a side effect of diabetes), and described is a research project comparing two types of photocoagulation treatment. (DB)

  6. China Advanced Research Reactor Project Progress in 2011

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    2011, China Advanced Research Reactor (CARR) Project finished the B stage commissioning and resolved the relative technical problems. Meanwhile, the acceptance items and the cold neutron source were carrying out.

  7. Cell Science and Cell Biology Research at MSFC: Summary

    Science.gov (United States)

    2003-01-01

    The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

  8. Crowdfunding Campaigns Help Researchers Launch Projects and Generate Outreach.

    Science.gov (United States)

    Dahlhausen, Katherine; Krebs, Bethany L; Watters, Jason V; Ganz, Holly H

    2016-03-01

    Organizers of participatory research (citizen science) projects can generate funds and outreach through crowdfunding. Here we provide insights from three successful science crowdfunding campaigns recently completed on Indiegogo, Experiment, and Kickstarter. Choosing a crowdfunding platform that fits the project is just the beginning; a successful campaign reflects its content, management, and marketing, and some researchers may need to acquire new skills. In addition, the growing trend of crowdfunding for science reinforces the importance of academic engagement with social media.

  9. Crowdfunding Campaigns Help Researchers Launch Projects and Generate Outreach

    Directory of Open Access Journals (Sweden)

    Katherine Dahlhausen

    2015-11-01

    Full Text Available Organizers of participatory research (citizen science projects can generate funds and outreach through crowdfunding. Here we provide insights from three successful science crowdfunding campaigns recently completed on Indiegogo, Experiment, and Kickstarter. Choosing a crowdfunding platform that fits the project is just the beginning; a successful campaign reflects its content, management, and marketing, and some researchers may need to acquire new skills. In addition, the growing trend of crowdfunding for science reinforces the importance of academic engagement with social media.

  10. Crowdfunding Campaigns Help Researchers Launch Projects and Generate Outreach.

    Science.gov (United States)

    Dahlhausen, Katherine; Krebs, Bethany L; Watters, Jason V; Ganz, Holly H

    2016-03-01

    Organizers of participatory research (citizen science) projects can generate funds and outreach through crowdfunding. Here we provide insights from three successful science crowdfunding campaigns recently completed on Indiegogo, Experiment, and Kickstarter. Choosing a crowdfunding platform that fits the project is just the beginning; a successful campaign reflects its content, management, and marketing, and some researchers may need to acquire new skills. In addition, the growing trend of crowdfunding for science reinforces the importance of academic engagement with social media. PMID:27047586

  11. Crowdfunding Campaigns Help Researchers Launch Projects and Generate Outreach

    OpenAIRE

    Katherine Dahlhausen; Krebs, Bethany L.; Watters, Jason V.; Ganz, Holly H.

    2015-01-01

    Organizers of participatory research (citizen science) projects can generate funds and outreach through crowdfunding. Here we provide insights from three successful science crowdfunding campaigns recently completed on Indiegogo, Experiment, and Kickstarter. Choosing a crowdfunding platform that fits the project is just the beginning; a successful campaign reflects its content, management, and marketing, and some researchers may need to acquire new skills. In addition, the growing trend of cro...

  12. Which Type of Inquiry Project Do High School Biology Students Prefer: Open or Guided?

    Science.gov (United States)

    Sadeh, Irit; Zion, Michal

    2012-01-01

    In teaching inquiry to high school students, educators differ on which method of teaching inquiry is more effective: Guided or open inquiry? This paper examines the influence of these two different inquiry learning approaches on the attitudes of Israeli high school biology students toward their inquiry project. The results showed significant…

  13. Multiweek Cell Culture Project for Use in Upper-Level Biology Laboratories

    Science.gov (United States)

    Marion, Rebecca E.; Gardner, Grant E.; Parks, Lisa D.

    2012-01-01

    This article describes a laboratory protocol for a multiweek project piloted in a new upper-level biology laboratory (BIO 426) using cell culture techniques. Human embryonic kidney-293 cells were used, and several culture media and supplements were identified for students to design their own experiments. Treatments included amino acids, EGF,…

  14. Women in Grains Research Project--Extract.

    Science.gov (United States)

    Berrisford, Nickie

    Research aimed at recognizing, encouraging, enhancing, and harnessing the skills and contributions of women in the Australian grains industry involved a number of women in Victoria in focus groups, telephone interviews, and questionnaire surveys. Results indicate that women perceived themselves as providing guidance, operational assistance,…

  15. Needs Assessment in Health Research Projects: A New Approach to Project Management in Iran

    Directory of Open Access Journals (Sweden)

    Niloofar Peykari

    2013-02-01

    Full Text Available Background: The science and technology health plan has defined the outline of health research to the national vision of Iran by 2025. The aim of this study was to focus on the process of needs assessment of health research projects also health research priority setting in Iran.Methods: The project management life cycle has four phases: Initiation, Planning, Execution and Closure. Based on abovementioned points we conducted the study.Results: Focusing on the needs assessment led to systematic implementation of needs assessment of health project in all of the medical sciences universities. Parallel with this achieved strategies health research priority setting was followed through specific process from empowerment to implementation.Conclusion: We should adopt with more systematic progressive methods of health project managements for both our national convenience as well as our international health research programs.

  16. Fiscal 1993 technological survey report. R and D project for industrial science and technology (Assignment by NEDO/R and D of biochip - survey on biological research of biochip); 1993 nendo bio soshi no kenkyu kaihatsu seika hokokusho. Bio soshi seibutsu kenkyu chosa

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-04-01

    As a part of the R and D of a biochip, for the purpose of establishing fundamental technology in connection with a biochip having a new function that is nonexistent in a semiconductor, a committee for biological research and survey of biochip was organized, operating research activities, surveying and compiling research situations and technological trend at the forefront of each field, in regard to information processing in the biological field, brain-memory related information processing in the medical field, and biologically simulated information processing in the engineering field. The results were summarized in the following seven areas. 1. neurology of memory, 2. the frontal lobe and recognition, 3. function of the olfactory lobe and neural connection between the olfactory lobe and the hippocampus, 4. the cerebral fundus nucleus and function, 5. coordinate change from vision to motion in the brain, and 6. control of transient potassium current by the astroglia cell in the mouth and the hippocampus cultured nerve cell. (NEDO)

  17. Focusing Information Systems Post-Graduate Research Projects

    Directory of Open Access Journals (Sweden)

    Gail Ridley

    1996-11-01

    Full Text Available This paper reports on an investigation of mechanisms that assist Information Systems post-graduate research students to focus their projects. An evaluation is presented of the experiences of Information Systems research students in focussing their research projects based on a survey conducted of students who participated in two of the first three Information Systems doctoral consortia to be held in Australia. The survey sought to determine whether a doctoral consortium or 'systematic expert review' is the most valuable mechanism for focussing a research proposal. Systematic expert review was considered by the students to be more effective than the doctoral consortium process for the purpose of focussing their research project proposals.

  18. Characterization of an orthovoltage biological irradiator used for radiobiological research

    International Nuclear Information System (INIS)

    Orthovoltage irradiators are routinely used to irradiate specimens and small animals in biological research. There are several reports on the characteristics of these units for small field irradiations. However, there is limited knowledge about use of these units for large fields, which are essential for emerging large-field irregular shape irradiations, namely total marrow irradiation used as a conditioning regimen for hematological malignancies. This work describes characterization of a self-contained Orthovoltage biological irradiator for large fields using measurements and Monte Carlo simulations that could be used to compute the dose for in vivo or in vitro studies for large-field irradiation using this or a similar unit. Percentage depth dose, profiles, scatter factors, and half-value layers were measured and analyzed. A Monte Carlo model of the unit was created and used to generate depth dose and profiles, as well as scatter factors. An ion chamber array was also used for profile measurements of flatness and symmetry. The output was determined according to AAPM Task Group 61 guidelines. The depth dose measurements compare well with published data for similar beams. The Monte Carlo–generated depth dose and profiles match our measured doses to within 2%. Scatter factor measurements indicate gradual variation of these factors with field size. Dose rate measured by placing the ion chamber atop the unit's steel plate or solid water indicate enhanced readings of 5 to 28% compared with those measured in air. The stability of output over a 5-year period is within 2% of the 5-year average. (author)

  19. AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.; Bair, K.; Ross, J. [eds.

    1994-03-01

    The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.

  20. Biological and Chemical Technologies Research at OIT: Annual Summary Report, FY 1997

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, G.

    1998-03-01

    The annual summary report presents the fiscal year (FY) 1 997 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program. This BCTR program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1997 (ASR 97) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization; selected technical and programmatic highlights for 1 997; detailed descriptions of individual projects; and a listing of program output, including a bibliography of published work, patents, and awards arising from work supported by the program.

  1. IMPROVEMENT OF STUDENTS’ SCIENTIFIC WRITING OF BIOLOGY EDUCATION OF SEBELAS MARET UNIVERSITY THROUGH READING PROJECT BASED LEARNING

    Directory of Open Access Journals (Sweden)

    R. M. Probosari

    2015-04-01

    Full Text Available This study examined how students’ scientific writing skills changed over as they participated in the Reading Project Based Learning (RPjBL model. This action research was conducted by Biology Teacher of Education Program Faculty of Teacher Training and Education in SebelasMaret University. The results show that the scientificwriting level increased on the last writing activities. It was suggested that RPjBL could have a positive impact on students’ scientific writing. Students who experienced the RPjBL emphasized the sentences reflecting the application and used high cognitive level sentences.   

  2. The Arctic DP Research Project: Effective Stationkeeping in Ice

    Directory of Open Access Journals (Sweden)

    Roger Skjetne

    2014-10-01

    Full Text Available Stress on the environment from a potentially growing energy use is set to rise. Without doubt the energy resources in Arctic regions will be developed. An important goal will be to exploit the resources offered by for instance the Barents Sea as a new European energy province, and to do this in accordance with the principles of sustainable development that have successfully been used e.g. in the North Sea. The special edition of MIC on Arctic DP presents a set of articles that summarize to an extent the activities of the research project Arctic DP: Safe and green dynamic positioning operations of offshore vessels in an Arctic environment. This project was awarded in 2010 by the Research Council of Norway (RCN as a competence-building project (KMB project to NTNU and its partners Kongsberg Maritime, DNV GL, and Statoil. The objective was to target some of the challenges related to safe Arctic offshore operations by dynamic positioning. In this first article of the Arctic DP special edition we discuss the background for and establishment of the project, its planning and execution, and project closure. An overview is given for the scientific and engineering research performed in the project, with an account of what we have considered as Effective stationkeeping in ice by dynamic positioning. The corresponding research activities conducted under this main theme is summarized.

  3. The Towuti Drilling Project: paleoenvironments, biological evolution, and geomicrobiology of a tropical Pacific lake

    Science.gov (United States)

    Russell, James M.; Bijaksana, Satria; Vogel, Hendrik; Melles, Martin; Kallmeyer, Jens; Ariztegui, Daniel; Crowe, Sean; Fajar, Silvia; Hafidz, Abdul; Haffner, Doug; Hasberg, Ascelina; Ivory, Sarah; Kelly, Christopher; King, John; Kirana, Kartika; Morlock, Marina; Noren, Anders; O'Grady, Ryan; Ordonez, Luis; Stevenson, Janelle; von Rintelen, Thomas; Vuillemin, Aurele; Watkinson, Ian; Wattrus, Nigel; Wicaksono, Satrio; Wonik, Thomas; Bauer, Kohen; Deino, Alan; Friese, André; Henny, Cynthia; Imran; Marwoto, Ristiyanti; Ode Ngkoimani, La; Nomosatryo, Sulung; Ode Safiuddin, La; Simister, Rachel; Tamuntuan, Gerald

    2016-07-01

    The Towuti Drilling Project (TDP) is an international research program, whose goal is to understand long-term environmental and climatic change in the tropical western Pacific, the impacts of geological and environmental changes on the biological evolution of aquatic taxa, and the geomicrobiology and biogeochemistry of metal-rich, ultramafic-hosted lake sediments through the scientific drilling of Lake Towuti, southern Sulawesi, Indonesia. Lake Towuti is a large tectonic lake at the downstream end of the Malili lake system, a chain of five highly biodiverse lakes that are among the oldest lakes in Southeast Asia. In 2015 we carried out a scientific drilling program on Lake Towuti using the International Continental Scientific Drilling Program (ICDP) Deep Lakes Drilling System (DLDS). We recovered a total of ˜ 1018 m of core from 11 drilling sites with water depths ranging from 156 to 200 m. Recovery averaged 91.7 %, and the maximum drilling depth was 175 m below the lake floor, penetrating the entire sedimentary infill of the basin. Initial data from core and borehole logging indicate that these cores record the evolution of a highly dynamic tectonic and limnological system, with clear indications of orbital-scale climate variability during the mid- to late Pleistocene.

  4. Biorefinery and Carbon Cycling Research Project

    Energy Technology Data Exchange (ETDEWEB)

    Das, K. C., Adams; Thomas, T; Eiteman, Mark A; Kastner, James R; Mani, Sudhagar; Adolphson, Ryan

    2012-06-08

    In this project we focused on several aspects of technology development that advances the formation of an integrated biorefinery. These focus areas include: [ 1] pretreatment of biomass to enhance quality of products from thermochemical conversion; [2] characterization of and development of coproduct uses; [3] advancement in fermentation of lignocellulosics and particularly C5 and C6 sugars simultaneously, and [ 4] development of algal biomass as a potential substrate for the biorefinery. These advancements are intended to provide a diverse set of product choices within the biorefinery, thus improving the cost effectiveness of the system. Technical effectiveness was demonstrated in the thermochemical product quality in the form of lower tar production, simultaneous of use of multiple sugars in fermentation, use ofbiochar in environmental (ammonia adsorption) and agricultural applications, and production of algal biomass in wastewaters. Economic feasibility of algal biomass production systems seems attractive, relative to the other options. However, further optimization in all paths, and testing/demonstration at larger scales are required to fully understand the economic viabilities. The coproducts provide a clear picture that multiple streams of value can be generated within an integrated biorefinery, and these include fuels and products.

  5. Project Report: Undergraduate Student Research Program (USRP)

    Science.gov (United States)

    Gavin, Patricia

    2011-01-01

    To better understand geochemical processes occurring on Europa's seafloor, we investigated the effects of varying Fe?content in the seafloor rock and varying temperature. Iron is important in such geochemical processes as the production of methane through serpentinization (e.g. Allen and Seyfried, 2003) and can be a nutrient for microbes (Russell and Hall, 2006; Park and Kim, 2001). It can also offer clues as to the state of differentiation of Europa's core/mantle. If Europa is fully differentiated and contains an iron core, we would expect there to be little iron in the mantle and ocean floor whereas a homogeneous Europa would have iron evenly dispersed throughout the ocean floor. Furthermore, the composition of the ocean is a result of water?rock interactions at the seafloor. This project investigated the effects of temperature on geochemical processes, comparing high temperature (> 250oC) hydrothermal vents (Kelley et al., 2001) to lower temperature (20oC) cold seeps (e.g. Orphan et al., 2002).

  6. Small Hydropower Research and Development Technology Project

    Energy Technology Data Exchange (ETDEWEB)

    Blackmore, Mo [Near Space Systems, Inc.

    2013-12-06

    The objective of this work was to investigate, develop, and validate the next generation of small hydroturbine generator designs that maximize the energy transfer from flowing water to electrical power generation. What resulted from this effort was the design of a new technology hydroturbine that Near Space Systems (NSS) has named the Star*Stream© Hydroturbine. Using a design that eliminates nearly all of the shortfalls of conventional hydroturbines, the Star*Stream© Hydroturbine employs a new mechanical-to-electrical energy transfer hydro design that operates without lubrication of any kind, and does not introduce foreign chemicals or particulate matter from oil or drive shaft seal degradation into the hydro ecology. In its unique configuration, the Star*Stream© Hydroturbine is nearly environmentally inert, without the negative aspects caused by interrupting the ecological continuity, i.e., disruptions to sedimentation, water quality, habitat changes, human displacement, fish migration, etc., - while it ensures dramatically reduced timeframes to project completion. While a remarkable reduction in LCOE resulting from application of the Star*Stream© Hydroturbine technology has been the core achievement of the this effort, there have been numerous technological breakthroughs from the development effort.

  7. Ownership of user research in the project 'war room'

    DEFF Research Database (Denmark)

    Lima, Patricia; Sproedt, Henrik; Buur, Jacob

    2015-01-01

    from a project with four Danish medium-sized manufacturing companies aiming to become more competitive in the European export market. In the project, one challenge was how to convey results from customer interviews and user studies from the researcher team (which in all instances included a company...... manager) to the development team in each company. We chose to collaboratively build a ‘war room’ in each of the companies to make sense of research materials and establish design principles for products that would better align with customer needs.......This paper develops the notion of a project war room as an innovation practice in companies. We argue that the consistent use of a project war room, in which customer and user research serves as a background for design work, improve the quality of product innovation. We describe our experiences...

  8. Research project management 101: insiders' tips from Early Career Scientists

    Science.gov (United States)

    Cristini, Luisa; Pabortsava, Katsiaryna; Stichel, Torben

    2016-04-01

    From the very beginning of their career, it is important for Early Career Scientists (ECS) to develop project management skills to be able to organise their research efficiently. ECS are often in charge of specific tasks within their projects or for their teams. However, without specific training or tools, the successful completion of these assignments will depend entirely on the organisational skills of individual researchers. ECS are thus facing "sink-or-swim" situations, which can be either instructive or disastrous for their projects. Here we provide experience-based tips from fellow ECS that can help manage various project activities, including: 1. Communication with supervisors and peers 2. Lab management 3. Field trips (e.g., oceanographic campaigns) 4. Internships and collaborations with other institutions 5. Literature/background research 6. Conference convening These are potential "life buoys" for ECS, which will help them to carry out these tasks efficiently and successfully.

  9. Laboratory technology research: Abstracts of FY 1998 projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-11-01

    The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of the country: the world-class basic research capability of the DOE Office of Science (SC) national laboratories and the unparalleled entrepreneurial spirit of American industry. Projects supported by the LTR program in FY 1998 explore the applications of basic research advances relevant to DOE`s mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials, intelligent processing and manufacturing research, and environmental and biomedical research. Abstracts for 85 projects are contained in this report.

  10. Laboratory Technology Research: Abstracts of FY 1996 projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-31

    The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of this country: the world-class basic research capability of the DOE Energy Research (ER) multi-program national laboratories and the unparalleled entrepreneurial spirit of American industry. Projects supported by the LTR program are conducted by the five ER multi-program laboratories: Argonne, Brookhaven, Lawrence Berkeley, Oak Ridge, and Pacific Northwest National Laboratories. These projects explore the applications of basic research advances relevant to Department of Energy`s (DOE) mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials, intelligent processing/manufacturing research, and sustainable environments.

  11. Quantum Biology at the Cellular Level - elements of the research program

    OpenAIRE

    Bordonaro, Michael; Ogryzko, Vasily

    2013-01-01

    Quantum Biology is emerging as a new field at the intersection between fundamental physics and biology, promising novel insights into the nature and origin of biological order. We discuss several elements of QBCL (Quantum Biology at Cellular Level), a research program designed to extend the reach of quantum concepts to higher than molecular levels of biological organization. Key words. decoherence, macroscopic superpositions, basis-dependence, formal superposition, non-classical correlations,...

  12. Research project: "Promotion of optimum brain ageing"

    CERN Multimedia

    IT Department

    2009-01-01

    The Rehabilitation and Geriatrics Department of the Geneva University Hospitals (HUG) has signed a research protocol with CERN with a view to promoting better understanding of the mechanisms that trigger Alzheimer’s disease. Alzheimer’s disease is a form of dementia associated with memory loss, inability to make plans and spatial disorientation. With 24 million sufferers worldwide at present, a figure that is predicted to rise to 29 million by 2020, it represents a major challenge for the coming decades. Prevention is a key factor in slowing the alarming spread of this disease. Delaying the onset of the disease could reduce the total number of cases by 50%. Why CERN? CERN is an international research organisation with a workforce that is predominantly male (a section of the population that has been little studied so far) and has a high level of education. Moreover, its pensioners are easy to reach since the majority live in the Geneva area. The aim of the study is to ev...

  13. The Maine Garlic Project: A Participatory Research and Education Program

    Science.gov (United States)

    Fuller, David; Johnson, Steven B.

    2013-01-01

    Participatory research is a useful technique for collecting basic data over a large geographic area. Garlic production was chosen as a participatory research study focus in Maine. Project participants (285) received bulbs to plant, monitored their crop, and reported data online. Participants received a monthly educational newsletter to improve…

  14. Solar heating and cooling. Research and development: project summaries

    Energy Technology Data Exchange (ETDEWEB)

    1978-05-01

    The Conservation and Solar Applications Solar Heating and Cooling Research and Development Program is described. The evolution of the R and D program is described and the present program is outlined. A series of project descriptions summarizes the research and development presently supported for further development of collectors, thermal energy storage and heat exchangers, heat pumps, solar cooling, controls, and systems. (MHR)

  15. Pacific Lamprey Research and Restoration Project : Annual Report 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Close, David A.

    2002-11-01

    This report summarizes results of research activities conducted in 1999-2000. The findings in these chapters represent the efforts of the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) and collaborative efforts among other researchers working on Pacific lampreys (Lampetra tridentata) under this project. The findings in these chapters will help management and recovery of Pacific lampreys in the Columbia River Basin.

  16. Student Perceptions on Live-Case Projects: Undergraduate Marketing Research

    Science.gov (United States)

    Gundala, Raghava Rao; Singh, Mandeep; Baldwin, Andrew

    2014-01-01

    This paper is an investigation into undergraduate students' perceptions on use of live projects as a teaching pedagogy in marketing research courses. Students in undergraduate marketing research courses from fall 2009 to spring 2013 completed an online questionnaire consisting of 17 items. The results suggested that student understanding of…

  17. Modelling in cross-disciplinary authentic student research projects

    NARCIS (Netherlands)

    A. Heck

    2010-01-01

    In the Dutch secondary education system, students must carry out at the end of their school career a rather large research or design project to demonstrate their ability to apply acquired knowledge and skills while pursuing a research question or design goal in some depth. They are encouraged to cho

  18. THE CONTRIBUTION OF RESEARCH INSTITUTES IN EUREKA PROJECTS

    NARCIS (Netherlands)

    VANROSSUM, W; CABO, PG

    1995-01-01

    Technological cooperation between industrial firms and research institutes is studied at the project level. The various forms of cooperation, and the instances in which they are advantageous, are discussed. The authors then focus on situations in which the research institute acts as 'knowledge suppl

  19. Multiple Methods: Research Methods in Education Projects at NSF

    Science.gov (United States)

    Suter, Larry E.

    2005-01-01

    Projects on science and mathematics education research supported by the National Science Foundation (US government) rarely employ a single method of study. Studies of educational practices that use experimental design are very rare. The most common research method is the case study method and the second most common is some form of experimental…

  20. Final Project Report Load Modeling Transmission Research

    Energy Technology Data Exchange (ETDEWEB)

    Lesieutre, Bernard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Bravo, Richard [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Yinger, Robert [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Chassin, Dave [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Huang, Henry [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Lu, Ning [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Hiskens, Ian [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Venkataramanan, Giri [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-03-31

    The research presented in this report primarily focuses on improving power system load models to better represent their impact on system behavior. The previous standard load model fails to capture the delayed voltage recovery events that are observed in the Southwest and elsewhere. These events are attributed to stalled air conditioner units after a fault. To gain a better understanding of their role in these events and to guide modeling efforts, typical air conditioner units were testing in laboratories. Using data obtained from these extensive tests, new load models were developed to match air conditioner behavior. An air conditioner model is incorporated in the new WECC composite load model. These models are used in dynamic studies of the West and can impact power transfer limits for California. Unit-level and systemlevel solutions are proposed as potential solutions to the delayed voltage recovery problem.

  1. New York State Energy Research and Development Authority. Research projects` update project status as of March 31, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-07-01

    This report provides an update of the New York State Energy Research and Development Authority (NYSERDA) program. The NYSERDA research and development program has five major areas: industry, buildings, energy resources, transportation, and environment. NYSERDA organizes projects within these five major areas based on energy use and supply, and end-use sectors. Therefore, issues such as waste management, energy products and renewable energy technologies are addressed in several areas of the program. The project descriptions presented are organized within the five program areas. Descriptions of projects completed between the period April 1, 1996, and March 31, 1997, including technology-transfer activities, are at the end of each subprogram section.

  2. Project resumes: biological effects from electric fields associated with high-voltage transmission lines

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-01-01

    Abstracts of research projects are presented in the following areas: measurements and special facilities; cellular and subcellular studies; physiology; behavior; environmental effects; modeling, scaling and dosimetry; and high voltage direct current. (ACR)

  3. A new era for GPCR research: structures, biology anddrug discovery

    Institute of Scientific and Technical Information of China (English)

    H Eric XU; Rui-ping XIAO

    2012-01-01

    Cells in a living organism must communicate with each other through continuously sending and receiving messages.G-protein coupled receptors (GPCRs) are the largest family of communicating molecules at the cell surface.They transmit diverse extracellular signals,ranging from light and small chemical hormones to large peptide and protein hormones,and as such they play crucial roles in numerous physiological and pathological processes.More importantly,GPCRsare the most successful class of drug targets that are relevant to many major diseases,including cancer,heart failure,and inflammatory diseases.Over 50% of currently used drugs are targeted to GPCRs.However,these drugs target only 50-60 GPCRs,leaving the majority of human GPCRs,exceeding 800,unexplored for drug discovery.Given the prominent roles of GPCRs in biology and their successful track records as drug targets,GPCRs have become a hot frontier in basic research of life science and therapeutic discovery of translational medicines.

  4. Teachers as Researchers in a Major Research Project: Experience of Input and Output

    Science.gov (United States)

    Smith, C.; Blake, A.; Curwen, K.; Dodds, D.; Easton, L.; McNally, J.; Swierczek, P.; Walker, L.

    2009-01-01

    Teachers have long participated in collaborative research. However, they have generally had direct stakes in the outcomes. Teachers in the Early Professional Learning (EPL) Project used their insider status to gather data not directly related to their own practice. Lessons for integrating a group of teacher-researchers into a major project are…

  5. 76 FR 82286 - Applications for New Awards; Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2011-12-30

    ... Applications for New Awards; Disability and Rehabilitation Research Projects and Centers Program--Advanced Rehabilitation Research Training (ARRT) Projects AGENCY: Office of Special Education and Rehabilitative Services.... Overview Information Disability and Rehabilitation Research Projects and Centers Program--...

  6. 77 FR 40601 - Final Priority: Disability and Rehabilitation Research Projects and Centers Program; Disability...

    Science.gov (United States)

    2012-07-10

    ... Final Priority: Disability and Rehabilitation Research Projects and Centers Program; Disability...)--Disability and Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research... Projects and Centers Program administered by the National Institute on Disability and...

  7. 77 FR 34363 - Disability and Rehabilitation Research Projects and Centers Program; Traumatic Brain Injury Model...

    Science.gov (United States)

    2012-06-11

    ... Disability and Rehabilitation Research Projects and Centers Program; Traumatic Brain Injury Model Systems... Program--Disability Rehabilitation Research Project (DRRP)-- Traumatic Brain Injury Model Systems Centers... for the Disability and Rehabilitation Research Projects and Centers Program administered by...

  8. Environmental training research project. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-04-01

    Santa Fe Community College serves an area including the city and county of Santa Fe. The population has a high percentage of Hispanics and a Native American population of about 3%. The student body at the college generally reflects that of the service district. The college strives to recruit students from all segments of the population so there is representation among all ethnic and economic groups. The college strives to serve students and the community by offering educational opportunities that meet the needs of both elements and which will lead to gainful employment. Instruction is also offered to meets needs for retraining, upgrades, and personal enlightenment. The college started a hazardous materials management program in the fall of 1991 which has since been renamed environmental management. The purpose of this program is to prepare students for environmental careers, to provide required training such as OSHA HAZWOPER and refresher courses, and to provide educational opportunities that would make the public more environmentally aware. The program content needs to be studied to ensure we`re meeting the needs of the students and the business community. There had not been a significant opportunity to conduct this research.

  9. Preparing the "New" Biologist of the Future: Student Research at the Interface of Mathematics and Biology

    Science.gov (United States)

    Duncan, Sarah I.; Bishop, Pamela; Lenhart, Suzanne

    2010-01-01

    We describe a unique Research Experience for Undergraduates and Research Experience for Veterinary students summer program at the National Institute for Mathematical and Biological Synthesis on the campus of the University of Tennessee, Knoxville. The program focused on interdisciplinary research at the interface of biology and mathematics.…

  10. Undergraduate Research Involving Deaf and Hard-of-Hearing Students in Interdisciplinary Science Projects

    Directory of Open Access Journals (Sweden)

    Todd Pagano

    2015-05-01

    Full Text Available Scientific undergraduate research in higher education often yields positive outcomes for student and faculty member participants alike, with underrepresented students often showing even more substantial gains (academic, professional, and personal as a result of the experience. Significant success can be realized when involving deaf and hard-of-hearing (d/hh undergraduate students, who are also vastly underrepresented in the sciences, in interdisciplinary research projects. Even d/hh Associate degree level students and those in the first two years of their postsecondary careers can contribute to, and benefit from, the research process when faculty mentors properly plan/design projects. We discuss strategies, including the dissemination/communication of research results, for involving these students in research groups with different communication dynamics and share both findings of our research program and examples of successful chemical and biological research projects that have involved d/hh undergraduate students. We hope to stimulate a renewed interest in encouraging diversity and involving students with disabilities into higher education research experiences globally and across multiple scientific disciplines, thus strengthening the education and career pipeline of these students.

  11. Center for Neutron Research Project. Status report

    International Nuclear Information System (INIS)

    The Center for Neutron Research (CNR) will provide the world's best facilities for the study of neutron scattering. The CNR will contain a very high flux reactor that will achieve an extremely high power density (between 4 and 8 MW/L). The reactor is to be fueled with uranium silicide and cooled, moderated, and reflected by D2O. Initial reactor physics calculations indicate that a power level of 270 MW with a reactor core volume of 35 L will achieve a peak thermal flux in the reflector of 1020 neutrons x m-2 x s-1. The reactor fuel will be contained in thin (1.3-mm) plates, similar to those employed in the very successful High-Flux Isotope Reactor, and will be graded in the axial and radial directions. Coolant velocity is to be 27 m/s, and core inlet pressure is to be 5.6 MPa. Maximum fuel centerline temperature will be ∼3500C. Initial thermal-hydraulic studies indicate that some method of preventing the formation of aluminum oxide on the fuel clad is required if the highest performance is to be achieved. Tests to confirm these calculations are planned. One of the experimental facilities is to be a cold (10-MeV) neutron source. Calculations to determine the size of the source have been initiated, but additional cross-section data are needed. An abbreviated version of a tentative program plan for fiscal year 1987 and beyond is described. Total program expenditures are expected to be $40 million over 5 years

  12. Research on Bacteria in the Mainstream of Biology.

    Science.gov (United States)

    Magasanik, Boris

    1988-01-01

    Stresses the importance of investigating bacterial mechanisms to discover clues for a greater understanding of cells. Cites examples of study areas of biological significance which may reveal information about the evolution of prokaryotes and eukaryotes and lead to a comprehensive theory of cell biology. (RT)

  13. Research Progression on Biological Mechanism of Post-stroke Depression

    Institute of Scientific and Technical Information of China (English)

    Lin Facai; Huang Dehong

    2014-01-01

    The biological mechanism of post-stroke depression (PSD) is still unclear. However, there are two hypothesises including primary endogenous mechanism and reactive mechanism. This study mainly reviewed the biological mechanism of PSD from the aspects of neuroanatomy, neurotransmitter, neuroendocrinology, inlfammatory response, neurtrophin and neuropeptide.

  14. Human-Robot Interaction Directed Research Project

    Science.gov (United States)

    Sandor, Aniko; Cross, Ernest V., II; Chang, Mai Lee

    2014-01-01

    Human-robot interaction (HRI) is a discipline investigating the factors affecting the interactions between humans and robots. It is important to evaluate how the design of interfaces and command modalities affect the human's ability to perform tasks accurately, efficiently, and effectively when working with a robot. By understanding the effects of interface design on human performance, workload, and situation awareness, interfaces can be developed to appropriately support the human in performing tasks with minimal errors and with appropriate interaction time and effort. Thus, the results of research on human-robot interfaces have direct implications for the design of robotic systems. This DRP concentrates on three areas associated with interfaces and command modalities in HRI which are applicable to NASA robot systems: 1) Video Overlays, 2) Camera Views, and 3) Command Modalities. The first study focused on video overlays that investigated how Augmented Reality (AR) symbology can be added to the human-robot interface to improve teleoperation performance. Three types of AR symbology were explored in this study, command guidance (CG), situation guidance (SG), and both (SCG). CG symbology gives operators explicit instructions on what commands to input, whereas SG symbology gives operators implicit cues so that operators can infer the input commands. The combination of CG and SG provided operators with explicit and implicit cues allowing the operator to choose which symbology to utilize. The objective of the study was to understand how AR symbology affects the human operator's ability to align a robot arm to a target using a flight stick and the ability to allocate attention between the symbology and external views of the world. The study evaluated the effects type of symbology (CG and SG) has on operator tasks performance and attention allocation during teleoperation of a robot arm. The second study expanded on the first study by evaluating the effects of the type of

  15. Tritium research laboratory cleanup and transition project final report

    International Nuclear Information System (INIS)

    This Tritium Research Laboratory Cleanup and Transition Project Final Report provides a high-level summary of this project's multidimensional accomplishments. Throughout this report references are provided for in-depth information concerning the various topical areas. Project related records also offer solutions to many of the technical and or administrative challenges that such a cleanup effort requires. These documents and the experience obtained during this effort are valuable resources to the DOE, which has more than 1200 other process contaminated facilities awaiting cleanup and reapplication or demolition

  16. Dryden Flight Research Center Critical Chain Project Management Implementation

    Science.gov (United States)

    Hines, Dennis O.

    2012-01-01

    In Fiscal Year 2011 Dryden Flight Research Center (DFRC) implemented a new project management system called Critical Chain Project Management (CCPM). Recent NASA audits have found that the Dryden workforce is strained under increasing project demand and that multi-tasking has been carried to a whole new level at Dryden. It is very common to have an individual work on 10 different projects during a single pay period. Employee surveys taken at Dryden have identified work/life balance as the number one issue concerning employees. Further feedback from the employees indicated that project planning is the area needing the most improvement. In addition, employees have been encouraged to become more innovative, improve job skills, and seek ways to improve overall job efficiency. In order to deal with these challenges, DFRC management decided to adopt the CCPM system that is specifically designed to operate in a resource constrained multi-project environment. This paper will discuss in detail the rationale behind the selection of CCPM and the goals that will be achieved through this implementation. The paper will show how DFRC is tailoring the CCPM system to the flight research environment as well as laying out the implementation strategy. Results of the ongoing implementation will be discussed as well as change management challenges and organizational cultural changes. Finally this paper will present some recommendations on how this system could be used by selected NASA projects or centers.

  17. The Network of European Research and Development Projects

    CERN Document Server

    Barber, M J; Krüger, T; Roediger-Schluga, T

    2005-01-01

    We describe collaboration networks consisting of research projects funded by the European Union and the organizations involved in those projects. The networks are of substantial size and complexity, but are important to understand due to the significant impact they could have on research policies and national economies in the EU. In empirical determinations of the network properties, we observe characteristics similar to other collaboration networks, including scale-free degree distributions, small diameter, and high clustering. We present some plausible models for the formation and structure of networks with the observed properties.

  18. Crowd-sourced Archaeological Research: The MicroPasts Project

    Directory of Open Access Journals (Sweden)

    Chiara Bonacchi

    2014-10-01

    Full Text Available This paper offers a brief introduction to MicroPasts, a web-enabled crowd-sourcing and crowd-funding project whose overall goal is to promote the collection and use of high quality research data via institutional and community collaborations, both on- and off-line. In addition to introducing this initiative, the discussion below is a reflection of its lead author’s core contribution to the project and will dwell in more detail on one particular aspect of MicroPasts: its relevance to research and practice in public archaeology, cultural policy and heritage studies.

  19. Lower Columbia River Terminal Fisheries Research Project : Final Environmental Assessment.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1995-04-01

    This notice announces BPA`S`s decision to fund the Oregon Department of Fish and Wildlife (ODFW), the Washington Department of Fish and Wildlife (WDFW), and the Clatsop Economic Development Committee for the Lower Columbia River Terminal Fisheries Research Project (Project). The Project will continue the testing of various species/stocks, rearing regimes, and harvest options for terminal fisheries, as a means to increase lower river sport and commercial harvest of hatchery fish, while providing both greater protection of weaker wild stocks and increasing the return of upriver salmon runs to potential Zone 6 Treaty fisheries. The Project involves relocating hatchery smolts to new, additional pen locations in three bays/sloughs in the lower Columbia River along both the Oregon and Washington sides. The sites are Blind Slough and Tongue Point in Clatsop County, Oregon, and Grays Bay/Deep River, Wahkiakum County, Washington. The smolts will be acclimated for various lengths of time in the net pens and released from these sites. The Project will expand upon an existing terminal fisheries project in Youngs Bay, Oregon. The Project may be expanded to other sites in the future, depending on the results of this initial expansion. BPA`S has determined the project is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement is not required, and BPA`S is issuing this FONSI.

  20. Researchers Reveal Ecological Roles of Biological Soil Crusts in Desert

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Biological soil crust is a complex organic integrity of cyanobacteria, green algae, lichens and mosses, fungi, and other bacteria. This is a common and widespread phenomenon in desert areas all over the world. Biologically,this kind of soil crust differs a lot from physical ones in terms of physical and chemical properties, and become important biological factors in vegetation succession. Despite its unassuming appearance, the crust plays a significant role in the desert ecosystem, involving the process of soil formation, stability and fertility,the prevention of soil erosion by water or wind, the increased possibility of vascular plants colonization, and the stabilization of sand dunes.

  1. Research in progress: FY 1992. Summaries of projects

    Energy Technology Data Exchange (ETDEWEB)

    1993-08-01

    The Biological and Environmental Research (BER) Program of OHER has two main missions: (1) to develop the knowledge base necessary to identify, understand, and anticipate the long-term health and environmental consequences of energy use and development and (2) to utilize the Department`s unique scientific and technological capabilities to solve major scientific problems in medicine, biology, and the environment. These missions reflect a commitment to develop the beneficial uses of advanced energy technologies while at the same time assuring that any potentially adverse health and environmental impacts of the Nation`s energy policies are fully identified and understood. The BER Program includes research in atmospheric, marine, and terrestrial processes, including the linkage between the use in greenhouse gases, carbon dioxide, and regional and global climate change; in molecular and subcellular mechanisms underlying human somatic and genetic processes and their responses to energy-related environmental toxicants; in nuclear medicine, structural biology, the human genome, measurement sciences and instrumentation, and other areas that require the unique capabilities of the Department`s laboratory system. The principal areas of research are Health Research and Environmental Research.

  2. Data management for community research projects: A JGOFS case study

    Science.gov (United States)

    Lowry, Roy K.

    1992-01-01

    Since the mid 1980s, much of the marine science research effort in the United Kingdom has been focused into large scale collaborative projects involving public sector laboratories and university departments, termed Community Research Projects. Two of these, the Biogeochemical Ocean Flux Study (BOFS) and the North Sea Project incorporated large scale data collection to underpin multidisciplinary modeling efforts. The challenge of providing project data sets to support the science was met by a small team within the British Oceanographic Data Centre (BODC) operating as a topical data center. The role of the data center was to both work up the data from the ship's sensors and to combine these data with sample measurements into online databases. The working up of the data was achieved by a unique symbiosis between data center staff and project scientists. The project management, programming and data processing skills of the data center were combined with the oceanographic experience of the project communities to develop a system which has produced quality controlled, calibrated data sets from 49 research cruises in 3.5 years of operation. The data center resources required to achieve this were modest and far outweighed by the time liberated in the scientific community by the removal of the data processing burden. Two online project databases have been assembled containing a very high proportion of the data collected. As these are under the control of BODC their long term availability as part of the UK national data archive is assured. The success of the topical data center model for UK Community Research Project data management has been founded upon the strong working relationships forged between the data center and project scientists. These can only be established by frequent personal contact and hence the relatively small size of the UK has been a critical factor. However, projects covering a larger, even international scale could be successfully supported by a

  3. Technology Base Research Project for electrochemical energy storage

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, Kim (ed.)

    1991-06-01

    The US DOE's Office of Propulsion Systems provides support for an electrochemical energy storage program, which includes R D on advanced rechargeable batteries and fuel cells. A major goal of this program is to develop electrochemical power sources suitable for application in electric vehicles (EVs). The program centers on advanced systems that offer the potential for high performance and low life-cycle costs, both of which are necessary to permit significant penetration into commercial markets. The general R D areas addressed by the project include identification of new electrochemical couples for advanced batteries, determination of technical feasibility of the new couples, improvements in battery components and materials, establishment of engineering principles applicable to electrochemical energy storage and conversion, and the development of air-system (fuel cell, metal/air) technology for transportation applications. Major emphasis is given to applied research which will lead to superior performance and lower life-cycle costs. The TBR Project is divided into three major project elements: Exploratory Research, Applied Science Research, and Air Systems Research. Highlights of each project element are summarized according to the appropriate battery system or electrochemical research area. 16 figs., 4 tabs.

  4. Can we combine symptom scales for collaborative research projects?

    LENUS (Irish Health Repository)

    Lyne, John P

    2012-02-01

    Collaborative research projects have the potential to answer important research questions, which may otherwise require huge resources, funding, and time to complete. There are several scales for measuring psychotic symptoms in schizophrenia and other psychotic disorders, with the Scale for Assessment of Positive Symptoms (SAPS), Scale for Assessment of Negative Symptoms (SANS), Positive and Negative Symptom Scale (PANSS), and the Brief Psychiatric Rating Scale (BPRS) being among the most commonly used. High quality research efforts have used these three scales in different projects, and in order to merge study efforts, some means of combining data from these scales may be necessary. We reviewed correlations in published studies for these three scales, finding them to be highly correlated, however on comparison of the three scales there were considerable clinical differences between them. The paper discusses potential methods for combining the scales in collaborative research, including use of the recently developed standardised remission criteria for schizophrenia.

  5. University-Level Research Projects for High School Students

    Science.gov (United States)

    McConnell, Mark L.

    2000-01-01

    The goal of this project was to provide an opportunity for high school students to participate in university-level research projects. In this case, students from Pinkerton Academy (Derry, New Hampshire) were invited to participate in efforts to catalog data from the COMPTEL experiment on NASA's Compton Gamma-Ray Observatory (CGRO). These activities were part of a senior level honors course at Pinkerton. Although the success of this particular program was rather limited, we feel that the general concept is a sound one. In principle, the concept of partnerships between local schools and university researchers is one that could be especially attractive to soft money researchers. Programs can be carefully designed to benefit both the students and the research program.

  6. Energy secretary's priorities include San Francisco area research projects

    CERN Multimedia

    Widener, A

    2003-01-01

    "Bay Area research labs got a big boost Monday when the Secretary of Energy unveiled his priorities for major research projects his agency hopes to fund over the next two decades. Among the agency's 28 top priorities are a major computer expansion and an experiment examining the expanding universe that could be housed at Lawrence Berkeley Lab and a powerful X-ray laser planned for the Stanford Linear Accelerator Center" (1 page).

  7. Laboratory technology research - abstracts of FY 1997 projects

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    The Laboratory Technology Research (LTR) program supports high-risk, multidisciplinary research partnerships to investigate challenging scientific problems whose solutions have promising commercial potential. These partnerships capitalize on two great strengths of this country: the world-class basic research capability of the DOE Energy Research (ER) multi-program national laboratories and the unparalleled entrepreneurial spirit of American industry. A distinguishing feature of the ER multi-program national laboratories is their ability to integrate broad areas of science and engineering in support of national research and development goals. The LTR program leverages this strength for the Nation`s benefit by fostering partnerships with US industry. The partners jointly bring technology research to a point where industry or the Department`s technology development programs can pursue final development and commercialization. Projects supported by the LTR program are conducted by the five ER multi-program laboratories. These projects explore the applications of basic research advances relevant to DOE`s mission over a full range of scientific disciplines. The program presently emphasizes three critical areas of mission-related research: advanced materials; intelligent processing/manufacturing research; and sustainable environments.

  8. Project SunSHINE: A Student Based Solar Research Program

    Science.gov (United States)

    Donahue, R.

    2000-12-01

    Eastchester Middle School (NY) is currently conducting an ongoing, interdisciplinary solar research program entitled Project SunSHINE, for Students Help Investigate Nature in Eastchester. Students are to determine how ultraviolet and visible light levels vary throughout the year at the school's geographic location, and to ascertain if any measured variations correlate to daily weather conditions or sunspot activity. The educational goal is to provide students the opportunity to conduct original and meaningful scientific research, while learning to work collaboratively with peers and teachers in accordance with national mathematics, science and technology standards. Project SunSHINE requires the student researchers to employ a number of technologies to collect and analyze data, including light sensors, astronomical imaging software, an onsite AirWatch Weather Station, Internet access to retrieve daily solar images from the National Solar Observatory's Kitt Peak Vacuum Telescope, and two wide field telescopes for live sunspot observations. The program has been integrated into the science, mathematics, health and computer technology classes. Solar and weather datasets are emailed weekly to physicist Dr. Gil Yanow of the Jet Propulsion Laboratory for inclusion in his global study of light levels. Dr. Yanow credited the Project SunSHINE student researchers last year for the discovery of an inverse relationship between relative humidity and ultraviolet light levels. The Journal News Golden Apple Awards named Project SunSHINE the 1999 New York Wired Applied Technology Award winner. This honor recognizes the year's outstanding educational technology program at both the elementary and secondary level, and included a grant of \\$20,000 to the research program. Teacher training and image processing software for Project SunSHINE has been supplied by The Use of Astronomy in Research Based Science Education (RBSE), a Teacher Enhancement Program funded by the National Science

  9. Which Type of Inquiry Project Do High School Biology Students Prefer: Open or Guided?

    Science.gov (United States)

    Sadeh, Irit; Zion, Michal

    2012-10-01

    In teaching inquiry to high school students, educators differ on which method of teaching inquiry is more effective: Guided or open inquiry? This paper examines the influence of these two different inquiry learning approaches on the attitudes of Israeli high school biology students toward their inquiry project. The results showed significant differences between the two groups: Open inquiry students were more satisfied and felt they gained benefits from implementing the project to a greater extent than guided inquiry students. On the other hand, regarding documentation throughout the project, guided inquiry students believed that they conducted more documentation, as compared to their open inquiry peers. No significant differences were found regarding `the investment of time', but significant differences were found in the time invested and difficulties which arose concerning the different stages of the inquiry process: Open inquiry students believed they spent more time in the first stages of the project, while guided inquiry students believed they spent more time in writing the final paper. In addition, other differences were found: Open inquiry students felt more involved in their project, and felt a greater sense of cooperation with others, in comparison to guided inquiry students. These findings may help teachers who hesitate to teach open inquiry to implement this method of inquiry; or at least provide their students with the opportunity to be more involved in inquiry projects, and ultimately provide their students with more autonomy, high-order thinking, and a deeper understanding in performing science.

  10. Interdisciplinary physics research in the Japanese Hadron Project

    International Nuclear Information System (INIS)

    The Japanese Hadron Project (JHP) is a large future plan of interdisciplinary and international scope, aimed at basic physics research by creating and using various secondary unstable particle beams such as mesons, muons, neutrons and accelerated exotic nuclei. It comprises a high-intensity proton linac of 1 GeV, a compressor/stretcher ring and an ISOL/accelerator to deliver beams to MESON, NEUTRON and EXOTIC NUCLEI arena's. In addition, as the present ongoing project, we are pushing KAON arena based on the KEK 12 GeV proton synchrotron. The present paper describes the scientific motivation and technological bases for this future project as well as the presently going pre-JHP research activities. (author)

  11. The SIMRAND methodology - Simulation of Research and Development Projects

    Science.gov (United States)

    Miles, R. F., Jr.

    1984-01-01

    In research and development projects, a commonly occurring management decision is concerned with the optimum allocation of resources to achieve the project goals. Because of resource constraints, management has to make a decision regarding the set of proposed systems or tasks which should be undertaken. SIMRAND (Simulation of Research and Development Projects) is a methodology which was developed for aiding management in this decision. Attention is given to a problem description, aspects of model formulation, the reduction phase of the model solution, the simulation phase, and the evaluation phase. The implementation of the considered approach is illustrated with the aid of an example which involves a simplified network of the type used to determine the price of silicon solar cells.

  12. Research in Undergraduate Instruction: A Biotech Lab Project for Recombinant DNA Protein Expression in Bacteria

    Science.gov (United States)

    Brockman, Mark; Ordman, Alfred B.; Campbell, A. Malcolm

    1996-06-01

    In the sophomore-level Molecular Biology and Biotechnology course at Beloit College, students learn basic methods in molecular biology in the context of pursuing a semester-long original research project. We are exploring how DNA sequence affects expression levels of proteins. A DNA fragment encoding all or part of the guanylate monokinase (gmk) sequence is cloned into pSP73 and expressed in E. coli. A monoclonal antibody is made to gmk. The expression level of gmk is determined by SDS gel elctrophoresis, a Western blot, and an ELISA assay. Over four years, an increase in enrollment in the course from 9 to 34 students, the 85% of majors pursuing advanced degrees, and course evaluations all support the conclusion that involving students in research during undergraduate courses encourages them to pursue careers in science.

  13. ChE Undergraduate Research Projects in Biomedical Engineering.

    Science.gov (United States)

    Stroeve, Pieter

    1981-01-01

    Describes an undergraduate research program in biomedical engineering at the State University of New York at Buffalo. Includes goals and faculty comments on the program. Indicates that 58 percent of projects conducted between 1976 and 1980 have been presented at meetings or published. (SK)

  14. Comparison of Scientific Research Projects of Education Faculties

    Science.gov (United States)

    Altunay, Esen; Tonbul, Yilmaz

    2015-01-01

    Many studies indicate that knowledge and knowledge production are the main predictors of social development, welfare and the ability to face the future with confidence. It could be argued that knowledge production is mainly carried out by universities. This study compares 1266 scientific research projects (SRPs) completed by faculties of education…

  15. Authentic student research projects on physics and the human body

    NARCIS (Netherlands)

    A. Heck; T. Ellermeijer; E. Kędzierska

    2008-01-01

    Students in Dutch senior secondary education are obliged to perform their own research project of approximately 80 hours. They are stimulated to choose the topic themselves (preferably with relations to two subjects, like physics and mathematics) and have a lot of freedom in the design of the resear

  16. The Children's Hearings Project Research Findings. A Summary Report.

    Science.gov (United States)

    Merry, Sally E.; And Others

    Since 1980 the Children's Hearings Project (CHP) in Cambridge, Massachusetts, has offered status offenders and their families mediation as an alternative to the courts. This report describes CPH's origins and summarizes the results of an extensive research study conducted during the first 2 years of its operation. The key findings were: (1)…

  17. Blogging across the Curriculum: An Action Research Project

    Science.gov (United States)

    Nichols, Andrea

    2012-01-01

    "Blogging across the curriculum: Integrating blogging in the elementary classroom" is an Action Research Project that sought to explore the level of engagement in the writing process by students in grades 3, 4 & 5 while blogging across the curriculum. Blogging took place in homeroom classrooms as well as in the school's math, science and…

  18. The Social Ecology Research Project, 1988-1991. Final Report.

    Science.gov (United States)

    Coleman, J. Michael; Minnett, Ann M.

    This report describes the Social Ecology Research Project, which assessed the foundations of personal-social competence in children with mental handicaps (MH). Children with mild MH (n=1,200) and their normally achieving peers (n=2,500), all ages 8-14, were studied over 3 years. Students were assessed in resource and regular classrooms, and…

  19. A Review of Research on Project STAR and Path Ahead

    Science.gov (United States)

    Sohn, Kitae

    2016-01-01

    Understanding the effects of class size reduction (CSR) has been an enduring issue in education. For the past 3 decades, Project STAR has stimulated research and policy discussions regarding the effects of CSR on a variety of outcomes. Schanzenbach (2007) reviewed STAR studies and concluded that small classes improved student academic outcomes.…

  20. Water Resources Research Grant Program project descriptions, fiscal year 1985

    Science.gov (United States)

    ,

    1985-01-01

    Information on each of the 24 projects funded by the U.S. Geological Survey in FY 1985 under section 105 of Public Law 93-242 (the Water Resources Research Act of 1984) is presented, including the grant number, organization, the period of performance, and a brief description of the work to be carried out. (Lantz-PTT)

  1. "Interventions for Promoting Research Knowledge Translation: Selection and Grading of Research Projects for Decision Makers"

    Directory of Open Access Journals (Sweden)

    Saharnaz Nedjat

    2009-05-01

    Full Text Available "nResearch-based knowledge transfer is considered an important principle in health. The status of knowledge transfer was studied in earlier studies and accordingly certain interventions were designed on the basis of its weaknesses. The idea was to design an algorithm for selection of research projects which are legible for knowledge transfer."nUsing literature review, grading of research projects was examined for its design and methodology. A decision was then made on the method of grading projects using relevant expert opinions. In the next stage, considering the validity of the aforementioned grading, and contextual examination, an algorithm was designed to define the method of selecting projects and their result transfer."nSince articles usually don't convey all the research findings, and don't reach decision makers on time, article writing doesn't seem sufficient for knowledge transfer. It is therefore necessary to adopt a mechanism that will convey valid research findings to target audiences. The algorithm presented in this article will help research authorities systematically decide about selecting research projects for knowledge transfer. Evaluation of this intervention was suggested for future researches. The results of this study can be beneficial to research policy makers in the university.

  2. On-going research projects at Ankara Nuclear Research Center in agriculture and animal science

    International Nuclear Information System (INIS)

    The projects in progress conducted by the Center comprise nuclear-aided researches in soil fertility, plant nutrition, plant protection, improvement of field crops, improvement of horticultural plants and forest trees by mutation breeding, in vitro culture technique with mutagen treatments, use of phosphogypsum in soil amelioration, sterilization of medical supplies, wastewater treatment, animal nutrition, animal health and productivity and accreditation. The on-going main projects involving several sub-projects with the above subjects were summarized for possible future collaborations. (author)

  3. Using Zebrafish to Implement a Course-Based Undergraduate Research Experience to Study Teratogenesis in Two Biology Laboratory Courses.

    Science.gov (United States)

    Sarmah, Swapnalee; Chism, Grady W; Vaughan, Martin A; Muralidharan, Pooja; Marrs, Jim A; Marrs, Kathleen A

    2016-08-01

    A course-based undergraduate research experience (CURE) spanning three semesters was introduced into freshman and sophomore biology classes, with the hypothesis that participation in a CURE affects skills in research, communication, and collaboration, which may help students persist in science. Student research projects were centered on the hypothesis that nicotine and caffeine exposure during early development affects gastrulation and heart development in zebrafish. First, freshmen generated original data showing distinct effects of embryonic nicotine and caffeine exposure on zebrafish heart development and function. Next, Cell Biology laboratory students continued the CURE studies and identified novel teratogenic effects of nicotine and caffeine during gastrulation. Finally, new freshmen continued the CURE research, examining additional toxicant effects on development. Students designed new protocols, made measurements, presented results, and generated high-quality preliminary data that were studied in successive semesters. By implementing this project, the CURE extended faculty research and provided a scalable model to address national goals to involve more undergraduates in authentic scientific research. In addition, student survey results support the hypothesis that CUREs provide significant gains in student ability to (1) design experiments, (2) analyze data, and (3) make scientific presentations, translating into high student satisfaction and enhanced learning. PMID:26829498

  4. 77 FR 480 - Applications for New Awards; Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-01-05

    ... Applications for New Awards; Disability and Rehabilitation Research Projects and Centers Program--Field.... Overview Information Disability and Rehabilitation Research Projects and Centers Program-- Field Initiated...) Projects program is to develop methods, procedures, and rehabilitation technology that maximize the...

  5. Research of the Mechanism of Enhancing Biological Treatment by Chitosan

    Institute of Scientific and Technical Information of China (English)

    CHEN Liang; QIN Bing; CHEN Dong-hui

    2006-01-01

    Chitosan of different molecular weight (M. W. ) was added into SBR bioreactor to treat domestic wastewater. From comparison of treatment efficiency, sludge activity, sludge structure etc., we revealed the mechanism that chitosan enhanced the biological treatment function of activated sludge. The results proved that, chitosan is certain to restrain the reaction of activated sludge, but it do improve the structure of sludge fiocs and increase the treatment efficiency of activated sludge. The bigger the M. W. of chitosan is, the better the efficiency of enhancing biological treatment can be.

  6. 77 FR 40596 - Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program...

    Science.gov (United States)

    2012-07-10

    ... Rehabilitation Research Projects and Centers program published in the Federal Register on April 28, 2006 (71 FR... Applications for New Awards: Disability and Rehabilitation Research Projects and Centers Program; Disability... Rehabilitation Research Projects and Centers Program-- Disability and Rehabilitation Research Projects...

  7. Summary results of an assessment of research projects in the Nuclear Medicine Research program

    International Nuclear Information System (INIS)

    In May 1987, OHER management requested the Office of Program Analysis (OPA) to conduct a peer review of the projects of the DOE Nuclear Medicine Research program. This was done using procedures and a quantitative methodology OPA developed for assessing DOE research programs. Sixty-three individual nuclear medicine projects were reviewed by seven panels; one panel on isotopes and radioisotopes, three on radiopharmacology, two on clinical feasibility, and one on instrumentation. Each panel consisted of five to ten knowledgeable reviewers. 5 figs

  8. Advances in Biological Water-saving Research: Challenge and Perspectives

    Institute of Scientific and Technical Information of China (English)

    Lun Shan; Xiping Deng; Suiqi Zhang

    2006-01-01

    Increasing the efficiency of water use by crops continues to escalate as a topic of concern because drought is a restrictive environmental factor for crop productivity worldwide. Greater yield per unit rainfall is one of the most important challenges in water-saving agriculture. Besides water-saving by irrigation engineering and conservation tillage, a good understanding of factors limiting and/or regulating yield now provides us with an opportunity to identify and then precisely select for physiological and breeding traits that increase the efficiency of water use and drought tolerance under water-limited conditions, biological water-saving is one means of achieving this goat. A definition of biological water-saving measures is proposed which embraces improvements in water-use efficiency (WUE) and drought tolerance, by genetic improvement and physiological regulation. The preponderance of biological water-saving measures is discussed and strategies identified for working within natural resource constraints. The technology and future perspectives of biological water saving could provide not only new water-saving techniques but also a scientific base for application of water-saving irrigation and conservation tillage.

  9. Sandia, California Tritium Research Laboratory transition and reutilization project

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, T.B. [Sandia National Lab., Albuquerque, NM (United States)

    1997-02-01

    This paper describes a project within Sandia National Laboratory to convert the shut down Tritium Research Laboratory into a facility which could be reused within the laboratory complex. In the process of decommissioning and decontaminating the facility, the laboratory was able to save substantial financial resources by transferring much existing equipment to other DOE facilities, and then expeditiously implementing a decontamination program which has resulted in the building being converted into laboratory space for new lab programs. This project of facility reuse has been a significant financial benefit to the laboratory.

  10. 2011 Joint Science Education Project: Research Experience in Polar Science

    Science.gov (United States)

    Wilkening, J.; Ader, V.

    2011-12-01

    The Joint Science Education Project (JSEP), sponsored by the National Science Foundation, is a two-part program that brings together students and teachers from the United States, Greenland, and Denmark, for a unique cross-cultural, first-hand experience of the realities of polar science field research in Greenland. During JSEP, students experienced research being conducted on and near the Greenland ice sheet by attending researcher presentations, visiting NSF-funded field sites (including Summit and NEEM field stations, both located on the Greenland ice sheet), and designing and conducting research projects in international teams. The results of two of these projects will be highlighted. The atmospheric project investigated the differences in CO2, UVA, UVB, temperature, and albedo in different Arctic microenvironments, while also examining the interaction between the atmosphere and water present in the given environments. It was found that the carbon dioxide levels varied: glacial environments having the lowest levels, with an average concentration of 272.500 ppm, and non-vegetated, terrestrial environments having the highest, with an average concentration of 395.143 ppm. Following up on these results, it is planned to further investigate the interaction of the water and atmosphere, including water's role in the uptake of carbon dioxide. The ecology project investigated the occurrence of unusual large blooms of Nostoc cyanobacteria in Kangerlussuaq area lakes. The water chemistry of the lakes which contained the cyanobacteria and the lakes that did not were compared. The only noticeable difference was of the lakes' acidity, lakes containing the blooms had an average pH value of 8.58, whereas lakes without the blooms had an average pH value of 6.60. Further investigation of these results is needed to determine whether or not this was a cause or effect of the cyanobacteria blooms. As a next step, it is planned to attempt to grow the blooms to monitor their effects on

  11. Achievements in Sino-German Interdisciplinary Major Research Project Published by Small

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Aiming at solving the complex problems in the molecular assembly research, as well as developing the potential application prospect, NSFC (National Natural Science Foundation of China) and DFG (Deutsche Forschungsgemeinschaft), jointly funded the first interdisciplinary major international collaborative re- search project(multilayered molecular assemblies., structure, dynamics and function) in 2008. Led by Pro- fessor Zhang Xi from Tsinghua University, Member of CAS and Professor Harald Fuchs from University of Mtinster in Germany, the research team, composed of more than 10 professors from different research fields including chemical science, physical science, biological science and material science, conducted the collaborative research. Recently, Wiley-VCH Small published a special issue (Feb. 16, 2012) of the re- search findings in the chemical design of molecular assembly and solution assembly, surface and interracial composite molecular assembly, and hybrid molecular assembly, which includes 2 literature reviews, 1 con- cept paper, 7 newsletters and 7 full papers.

  12. A Manual of Mosquito Control Projects and Committee Assignments for 4-H and Scouts Biology Class Projects, Organized Community Service Programs, and Individuals Interested in Environmental Management.

    Science.gov (United States)

    Hart, Richard A.

    The mosquito control projects presented in this manual were prepared from an educational viewpoint and are intended for use by students in 4-H and Scouts and as a supplement to high school and college biology course work. The major emphasis of the projects is on integrated pest management, an approach utilizing cost-effective control methods which…

  13. National Aeronautics and Space Administration Biological and Physical Research Enterprise Strategy

    Science.gov (United States)

    2003-01-01

    As the 21st century begins, NASA's new Vision and Mission focuses the Agency's Enterprises toward exploration and discovery.The Biological and Physical Research Enterprise has a unique and enabling role in support of the Agency's Vision and Mission. Our strategic research seeks innovations and solutions to enable the extension of life into deep space safely and productively. Our fundamental research, as well as our research partnerships with industry and other agencies, allow new knowledge and tech- nologies to bring improvements to life on Earth. Our interdisciplinary research in the unique laboratory of microgravity addresses opportunities and challenges on our home planet as well as in space environments. The Enterprise maintains a key role in encouraging and engaging the next generation of explorers from primary school through the grad- uate level via our direct student participation in space research.The Biological and Physical Research Enterprise encompasses three themes. The biological sciences research theme investigates ways to support a safe human presence in space. This theme addresses the definition and control of physiological and psychological risks from the space environment, including radiation,reduced gravity, and isolation. The biological sciences research theme is also responsible for the develop- ment of human support systems technology as well as fundamental biological research spanning topics from genomics to ecologies. The physical sciences research theme supports research that takes advantage of the space environment to expand our understanding of the fundamental laws of nature. This theme also supports applied physical sciences research to improve safety and performance of humans in space. The research partnerships and flight support theme establishes policies and allocates space resources to encourage and develop entrepreneurial partners access to space research.Working together across research disciplines, the Biological and Physical

  14. A Research Design for NASA-Funded Professional Development Projects

    Science.gov (United States)

    Bleicher, R. E.; Lambert, J.; Getty, S. R.

    2011-12-01

    This proposal outlines a research plan designed to measure gains in student learning resulting from their teachers participating in professional development. Project Description Misconceptions about global climate change (GCC) are prevalent in the general public (Kellstedt, Zahran, & Vedlitz, 2008; Washington & Cook, 2011). One solution is to provide high school students with a better grounding in the basic science and data that underlie GCC. The overarching goal of a NASA-funded project, Promoting Educational Leadership in Climate Change Literacy (PEL), is to increase GCC literacy in high school students. Research Design The research design is interpretative (Erickson, 2006), framed within a multi-method design, synthesizing both quantitative and qualitative data sources (Morse, 2003). Overall, the data will provide rich information about the PEL's impact on curriculum development, teacher pedagogical knowledge, and student learning. The expectancy-value theory of achievement motivation (E-V-C) (Fan, 2011; Wigfield & Eccles, 1994) provides a theoretical foundation for the research. Expectancy is the degree to which a teacher or student has reason to expect that they will be successful in school. Value indicates whether they think that performance at school will be worthwhile to them. Cost is the perceived sacrifices that must be undertaken, or factors that can inhibit, a successful performance at school. For students, data from an embedded E-V-C investigation will help articulate how E-V-C factors relate to student interest in science, continuing to study science, or embarking on STEM related careers. For teachers, the E-V-C measures will give insight into a key mediating variable on student achievement in science. The evaluation will seek to address research questions at the student and teacher levels. Table 1 presents a sample of research questions and data sources. This is a sample of a much larger set of questions that will be addressed in the project. Data

  15. Biological collections and ecological/environmental research: a review, some observations and a look to the future.

    Science.gov (United States)

    Pyke, Graham H; Ehrlich, Paul R

    2010-05-01

    collections have, for example, been particularly useful as sources of information regarding variation in attributes of individuals (e.g. morphology, chemical composition) in relation to environmental variables, and provided important information in relation to species' distributions, but less useful in the contexts of habitat associations and population sizes. Changes to policies, strategies and procedures associated with biological collections could mitigate these biases and limitations, and hence make such collections more useful in the context of ecological/environmental issues. Haphazard and opportunistic collecting could be replaced with strategies for adding to existing collections that prioritize projects that use biological collections and include, besides taxonomy and systematics, a focus on significant environmental/ecological issues. Other potential changes include increased recording of the nature and extent of collecting effort and information associated with each specimen such as nearby habitat and other individuals observed but not collected. Such changes have begun to occur within some institutions. Institutions that house biological collections should, we think, pursue a mission of 'understanding the life of the planet to inform its stewardship' (Krishtalka & Humphrey, 2000), as such a mission would facilitate increased use of biological collections in an ecological/environmental context and hence lead to increased appreciation, encouragement and support from the public for these collections, their associated research, and the institutions that house them.

  16. Interdisciplinarity as an Emergent Property: The Research Project “CINTERA” and the Study of Marine Eutrophication

    Directory of Open Access Journals (Sweden)

    Jennifer Bailey

    2015-07-01

    Full Text Available Research projects combining different disciplines are increasingly common and sought after by funding agencies looking for ways to achieve environmental, social, and economic sustainability. Creating and running a truly integrated research project that combines very different disciplines is, however, no easy task. Large-scale efforts to create interdisciplinary or transdisciplinary research efforts have reported on their experiences in trying to achieve this goal. This article shares the methods, challenges and achievements experienced by a smaller group of researchers who have developed an interdisciplinary approach based on former results of Norwegian and Chilean experiments. The project “A Cross-disciplinary Integrated Eco-system Eutrophication Research and Management Approach” (CINTERA, funded by the Research Council of Norway (RCN, project 216607, brings together the fields of political science, economics, marine biology/oceanography and marine bio-geo-chemistry to improve the understanding of marine eutrophication and its possible socio-economic impacts. CINTERA is a multidisciplinary project that evolved into an interdisciplinary project and in so doing, transformed the attitudes of participants. The transformative process was generated particularly by the need to work closely together in making the CINTERA project useful for policy-makers.

  17. Grete Kellenberger-Gujer: Molecular biology research pioneer.

    Science.gov (United States)

    Citi, Sandra; Berg, Douglas E

    2016-01-01

    Grete Kellenberger-Gujer was a Swiss molecular biologist who pioneered fundamental studies of bacteriophage in the mid-20(th) century at the University of Geneva. Her life and career stories are reviewed here, focusing on her fundamental contributions to our early understanding of phage biology via her insightful analyses of phenomena such as the lysogenic state of a temperate phage (λ), genetic recombination, radiation's in vivo consequences, and DNA restriction-modification; on her creative personality and interactions with peers; and how her academic advancement was affected by gender, societal conditions and cultural attitudes of the time. Her story is important scientifically, putting into perspective features of the scientific community from just before the molecular biology era started through its early years, and also sociologically, in illustrating the numerous "glass ceilings" that, especially then, often hampered the advancement of creative women. PMID:27607140

  18. Grete Kellenberger-Gujer: Molecular biology research pioneer.

    Science.gov (United States)

    Citi, Sandra; Berg, Douglas E

    2016-01-01

    Grete Kellenberger-Gujer was a Swiss molecular biologist who pioneered fundamental studies of bacteriophage in the mid-20(th) century at the University of Geneva. Her life and career stories are reviewed here, focusing on her fundamental contributions to our early understanding of phage biology via her insightful analyses of phenomena such as the lysogenic state of a temperate phage (λ), genetic recombination, radiation's in vivo consequences, and DNA restriction-modification; on her creative personality and interactions with peers; and how her academic advancement was affected by gender, societal conditions and cultural attitudes of the time. Her story is important scientifically, putting into perspective features of the scientific community from just before the molecular biology era started through its early years, and also sociologically, in illustrating the numerous "glass ceilings" that, especially then, often hampered the advancement of creative women.

  19. Phylogenetic Targeting of Research Effort in Evolutionary Biology

    OpenAIRE

    Arnold, Christian; Nunn, Charles Lindsay

    2010-01-01

    Many questions in comparative biology require that new data be collected, either to build a comparative database for the first time or to augment existing data. Given resource limitations in collecting data, the question arises as to which species should be studied to increase the size of comparative data sets. By taking hypotheses, existing data relevant to the hypotheses, and a phylogeny, we show that a method of “phylogenetic targeting” can systematically guide data collection while taking...

  20. MODEL ORGANISMS USED IN MOLECULAR BIOLOGY OR MEDICAL RESEARCH

    OpenAIRE

    Pandey Govind

    2011-01-01

    A model organism is a non-human species that is studied to understand specific biological phenomena with the expectation that investigations made in the organism model will provide insight into the workings of other organisms. The model organisms are widely used to explore potential causes and treatments for human as well as animal diseases when experiments on animals or humans would be unfeasible or considered less ethical. Studying model organisms may be informative, but care must be taken ...

  1. Human biological research since 2006 at the Christian-Albrechts-University in Kiel--aging, chronobiology, and high altitude adaptation.

    Science.gov (United States)

    Dittmar, Manuela

    2014-01-01

    This article reviews the research at the Department of Human Biology at the Christian-Albrechts-University in Kiel since 2006. The research focuses on the investigation of recent human populations with respect to aging, chronobiology, and adaptation to high altitude. The research areas are outlined presenting findings, ongoing projects and future directions. Aging research examines biological changes in humans considering that aging is a multidimensional process. Changes in body composition, resting energy metabolism, oxidative stress, and sleep have been examined. The applicability of specific research methods to older people has been tested. Chronobiological research concentrates on investigating circadian rhythms of humans. The emphasis lies on the sleep-wake rhythm, body temperature rhythms, hormonal rhythms (cortisol and melatonin) and the circadian expression of so-called clock genes which are involved in the generation of circadian rhythms. Association studies examine the relationship between defined chronobiological phenotypes and clock gene polymorphisms. Genetic aspects are as well investigated within the third research area on the adaptation of native populations to life at high altitude in the South American Andes. Both candidate gene analysis and epigenetic parameters are investigated. Future research will concentrate on the aging of the circadian system. PMID:24818445

  2. Research, design and development project Myoelectric Prosthesis of Upper Limb

    International Nuclear Information System (INIS)

    A Research Design and Development Project was developed of a myoelectric prosthesis for a pediatric patient presenting congenital amputation of the left forearm below the elbow. A multidisciplinary work-team was formed for this goal, in order to solve the several (/various) aspects regarding this project (mechanical, ergonomics, electronics, physical). The prosthesis as an electromechanical device was divided in several blocks, trying to achieve a focused development for each stage, acording to requisites. A mechanical prototype of the prothesis was designed and built along with the circuitry needed for EMG aquisition, control logic and drivers. Having acomplished the previuos stages, the project is now dealing with the definitions of the interface between the prosthesis and the patient, with promising perspectives

  3. Broad Consent For Research With Biological Samples: Workshop Conclusions

    Science.gov (United States)

    Grady, Christine; Eckstein, Lisa; Berkman, Ben; Brock, Dan; Cook-Deegan, Robert; Fullerton, Stephanie M.; Greely, Hank; Hansson, Mats G.; Hull, Sara; Kim, Scott; Lo, Bernie; Pentz, Rebecca; Rodriguez, Laura; Weil, Carol; Wilfond, Benjamin S.; Wendler, David

    2016-01-01

    Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The NIH Clinical Center’s Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the range of consent strategies, gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. The manuscript describes areas of agreement as well as areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and timely topic. PMID:26305750

  4. 76 FR 38134 - Final Priorities; Disability and Rehabilitation Research Projects and Centers Program-Disability...

    Science.gov (United States)

    2011-06-29

    ... Final Priorities; Disability and Rehabilitation Research Projects and Centers Program--Disability...; Disability and Rehabilitation Research Projects and Centers Program--Disability Rehabilitation Research... populations; (3) determine the best strategies and programs to improve rehabilitation outcomes for...

  5. 77 FR 21547 - Proposed Priorities; Disability and Rehabilitation Research Projects and Centers Program

    Science.gov (United States)

    2012-04-10

    ... Proposed Priorities; Disability and Rehabilitation Research Projects and Centers Program AGENCY: Office of... Rehabilitation Research (NIDRR)--Disability and Rehabilitation Research Projects and Centers Program... underserved populations; (3) determine best strategies and programs to improve rehabilitation outcomes...

  6. 76 FR 17396 - Proposed Priorities: Disability and Rehabilitation Research Projects and Centers Program

    Science.gov (United States)

    2011-03-29

    ... Proposed Priorities: Disability and Rehabilitation Research Projects and Centers Program AGENCY: Office of... Disability and Rehabilitation Research Projects and Centers Program administered by NIDRR. Specifically, this... programs to improve rehabilitation outcomes for underserved populations; (4) identify research gaps;...

  7. Introduction in Indonesian Social Sciences and Humanities Research Articles: How Indonesian Writers Justify Their Research Projects

    Science.gov (United States)

    Arsyad, Safnil; Wardhana, Dian Eka Chandra

    2014-01-01

    The introductory part of a research article (RA) is very important because in this section writers must argue about the importance of their research topic and project so that they can attract their readers' attention to read the whole article. This study analyzes RA introductions written by Indonesian writers in social sciences and humanities…

  8. Eurotrac: a co-ordinated project for applied tropospheric research

    Energy Technology Data Exchange (ETDEWEB)

    Borrell, P. [EUROTRAC International Scientific Secretariat, Garmisch-Partenkirchen (Germany)

    1995-12-31

    It was with the realisation that the scientific problems associated with regional air pollution could only be solved within the framework of an international interdisciplinary approach that in 1985 EUROTRAC, the European co-ordinated research project, was formed. Such an approach provides the scientific consensus necessary for the acceptance of regional air-pollution abatement measures by the countries affected. EUROTRAC is a EUREKA environmental project, studying the transport and chemical transformation of trace substances and pollutants in the troposphere. Three goals were specified the outset: (1) to increase the basic knowledge in atmospheric science, (2) to promote the technological development of sensitive, specific and fast response instruments for environmental research and development, and (3) to improve the scientific basis for taking future political decisions on environmental management in the European countries. Thus EUROTRAC was founded as a scientific project but had the specific intention that its results should be utilised in the formulation of policy. This presentation reviews the progress made towards each of the three goals and also indicates the proposed direction which a follow-on project is likely to take when EUROTRAC finishes at the end of 1995. (author)

  9. Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 87

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    Approximately 30 research projects are summarized in this report. Title of the project, contract number, company or university, award amount, principal investigators, objectives, and summary of technical progress are given for each project. Enhanced oil recovery projects include chemical flooding, gas displacement, and thermal recovery. Most of the research projects though are related to geoscience technology and reservoir characterization.

  10. Scientific drilling projects in ancient lakes: Integrating geological and biological histories

    Science.gov (United States)

    Wilke, Thomas; Wagner, Bernd; Van Bocxlaer, Bert; Albrecht, Christian; Ariztegui, Daniel; Delicado, Diana; Francke, Alexander; Harzhauser, Mathias; Hauffe, Torsten; Holtvoeth, Jens; Just, Janna; Leng, Melanie J.; Levkov, Zlatko; Penkman, Kirsty; Sadori, Laura; Skinner, Alister; Stelbrink, Björn; Vogel, Hendrik; Wesselingh, Frank; Wonik, Thomas

    2016-08-01

    Sedimentary sequences in ancient or long-lived lakes can reach several thousands of meters in thickness and often provide an unrivalled perspective of the lake's regional climatic, environmental, and biological history. Over the last few years, deep-drilling projects in ancient lakes became increasingly multi- and interdisciplinary, as, among others, seismological, sedimentological, biogeochemical, climatic, environmental, paleontological, and evolutionary information can be obtained from sediment cores. However, these multi- and interdisciplinary projects pose several challenges. The scientists involved typically approach problems from different scientific perspectives and backgrounds, and setting up the program requires clear communication and the alignment of interests. One of the most challenging tasks, besides the actual drilling operation, is to link diverse datasets with varying resolution, data quality, and age uncertainties to answer interdisciplinary questions synthetically and coherently. These problems are especially relevant when secondary data, i.e., datasets obtained independently of the drilling operation, are incorporated in analyses. Nonetheless, the inclusion of secondary information, such as isotopic data from fossils found in outcrops or genetic data from extant species, may help to achieve synthetic answers. Recent technological and methodological advances in paleolimnology are likely to increase the possibilities of integrating secondary information. Some of the new approaches have started to revolutionize scientific drilling in ancient lakes, but at the same time, they also add a new layer of complexity to the generation and analysis of sediment-core data. The enhanced opportunities presented by new scientific approaches to study the paleolimnological history of these lakes, therefore, come at the expense of higher logistic, communication, and analytical efforts. Here we review types of data that can be obtained in ancient lake drilling

  11. The importance of student research projects in dental education.

    Science.gov (United States)

    Guven, Y; Uysal, O

    2011-05-01

    In this article, our aim was to summarise students' research over 15 years at Istanbul University Faculty of Dentistry and to evaluate both the research activities from the students' perspectives and the effect of this activity on their undergraduate and postgraduate success. In 1992, dental students formed 'a Student Research Club' (SRC), which new students attend voluntarily and carry out a scientific project out with the normal curriculum every year. In total, 409 different students have presented 193 research projects at these meetings over 15 years. Seventy-four of these students were from other universities and presented 37 projects. In this research, a questionnaire containing 20 items was administered to 93 students who were the members of SRC to learn their own perception of the development of their academic and research skills and the broader impact of the club on their career. It was evaluated using Likert scale (ranged from strongly disagree to strongly agree). Student feedback was very positive and over three quarters (81%) of answers ranged between 'agree' and 'strongly agree'. When the cumulative grade point average (CGPA) of the 88 SRC members in the last 6 years (2003/2004 to 2008/2009) was evaluated as the school success rate, significant difference was found between the grades obtained by members and non-members (Pstudents had an intensive programme in the school, they were able to carry out this voluntary activity successfully and this activity contributed to their educational process. Students also believe that participation of them to this activity effects positively on both personal development and academic success. PMID:21492344

  12. BAO Plate Archive Project: Digitization, Electronic Database and Research Programmes

    Science.gov (United States)

    Mickaelian, A. M.; Abrahamyan, H. V.; Andreasyan, H. R.; Azatyan, N. M.; Farmanyan, S. V.; Gigoyan, K. S.; Gyulzadyan, M. V.; Khachatryan, K. G.; Knyazyan, A. V.; Kostandyan, G. R.; Mikayelyan, G. A.; Nikoghosyan, E. H.; Paronyan, G. M.; Vardanyan, A. V.

    2016-06-01

    The most important part of the astronomical observational heritage are astronomical plate archives created on the basis of numerous observations at many observatories. Byurakan Astrophysical Observatory (BAO) plate archive consists of 37,000 photographic plates and films, obtained at 2.6m telescope, 1m and 0.5m Schmidt type and other smaller telescopes during 1947-1991. In 2002-2005, the famous Markarian Survey (also called First Byurakan Survey, FBS) 1874 plates were digitized and the Digitized FBS (DFBS) was created. New science projects have been conducted based on these low-dispersion spectroscopic material. A large project on the whole BAO Plate Archive digitization, creation of electronic database and its scientific usage was started in 2015. A Science Program Board is created to evaluate the observing material, to investigate new possibilities and to propose new projects based on the combined usage of these observations together with other world databases. The Executing Team consists of 11 astronomers and 2 computer scientists and will use 2 EPSON Perfection V750 Pro scanners for the digitization, as well as Armenian Virtual Observatory (ArVO) database will be used to accommodate all new data. The project will run during 3 years in 2015-2017 and the final result will be an electronic database and online interactive sky map to be used for further research projects, mainly including high proper motion stars, variable objects and Solar System bodies.

  13. Research projects and university education in mechatronics and robotics

    OpenAIRE

    J. Świder

    2007-01-01

    Purpose: of this paper: The paper is focused on presenting the outcome of the task set before its author by Professor Leszek A. Dobrzanski seven years ago, when he was a Dean of the Faculty of Mechanical Engineering of the Silesian University of Technology in Gliwice, Poland, concerning the development and implementation of the Faculty concept of research projects and education in automatic control, mechatronics and robotics.Design/methodology/approach: The assumptions of the task and short ...

  14. Conceptual planning for Space Station life sciences human research project

    Science.gov (United States)

    Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.

    1986-01-01

    The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.

  15. Korea-China Optical Technology Research Centre Project

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Cheol Jung; Rhee, Y. J.; Jung, D. Y. and others

    2004-06-15

    The main objectives of this project are to establish the international collaboration basis of optical technologies between Korea and China. The combination of the Chinese advanced fundamental technologies with the Korean industrialization and commercialization infrastructures is realized, by ways of exchanging scientists and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to those of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both countries, providing technical advice and suggestions to the optical industries in the two countries is an another goal of this project. The state-of-the-arts of the Chinese technologies such as aerospace engineering, military defence technology, medical technology, laser fusion research, and so on, are known to be far above those of Korean and up to one of the most advanced in the world. Thus it is thought to be necessary that the acquisition of these technologies, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued in order to enhance the levels of Korean technologies in these fields.

  16. Research projects and university education in mechatronics and robotics

    Directory of Open Access Journals (Sweden)

    J. Świder

    2007-09-01

    Full Text Available Purpose: of this paper: The paper is focused on presenting the outcome of the task set before its author by Professor Leszek A. Dobrzanski seven years ago, when he was a Dean of the Faculty of Mechanical Engineering of the Silesian University of Technology in Gliwice, Poland, concerning the development and implementation of the Faculty concept of research projects and education in automatic control, mechatronics and robotics.Design/methodology/approach: The assumptions of the task and short description of the outcome of the activities undertaken for the creation of a laboratory infrastructure are provided, together with research scop formulation and commercial results of cooperation with industrial companies.Findings: Following several years of activities coordinated by the author, particularly good conditions of educating engineers in mechatronics have been provided, including a unique laboratory infrastructure that is used both for research schemes, commercial projects in mechatronics and robotics conducted for industrial companies.Practical implications: Practical implications include a unique laboratory infrastructure and well developed and implemented projects in the field of mechatronics.Originality/value: This is a brand new paper.

  17. Space research scientific and educational project of Moscow State University

    Science.gov (United States)

    Krasotkin, S. A.; Mjagkova, I. N.; Panasyuk, M. I.; Radchenko, V. V.; Ryazantseva, M. O.

    The scientific and educational project of space research was initiated in Lomonosov Moscow State University in order to incorporate modern space research in the university and high education, to popularize basics of space physics, and to enhance public interest in space exploration. On 20 January, 2005 the First Russian University Satellite UNIVERSITETSKIY was launched into circular polar orbit (inclination 83 deg., altitude 940-980 km). The onboard scientific complex TATYANA as well as the mission control and information receiving center, was designed and developed in Moscow State University. The scientific program of the mission include measurements of space radiation in different energy channels, and Earth UV luminosity and lightening. A multimedia lectures "Life of the Earth in the Solar Atmosphere" containing the basic information and demonstrations of the heliophysics (including Sun structure and solar activity, heliosphere and geophysics, solar-terrestrial connections and solar influence on the Earth's life) was created for upper high-school and junior university students. For the upper-university students there was created a dozen of special computerized lab exercises based on the experimental quasi-realtime data obtained from our satellites. Students specialized in space physics from a few Russian universities are involved in scientific work based. Educational program of the project (both the multimedia lectures and lab exercises) is concentrated to upper high school, middle university and special level for space physics students. The space research scientific and educational activity of Moscow State University is a non-profit project and is open for all interested parties.

  18. Korea-China Optical Technology Research Centre Project

    International Nuclear Information System (INIS)

    The main objectives of this project are to establish the international collaboration basis of optical technologies between Korea and China. The combination of the Chinese advanced fundamental technologies with the Korean industrialization and commercialization infrastructures is realized, by ways of exchanging scientists and informations, holding joint seminars, cooperative utilization of research resources. On the ground of this establishment, the optical technologies of Korea are supposed to be leveled up to those of the world-most advanced. At the same time, for the improvement of mutual benefit and financial profit of both countries, providing technical advice and suggestions to the optical industries in the two countries is an another goal of this project. The state-of-the-arts of the Chinese technologies such as aerospace engineering, military defence technology, medical technology, laser fusion research, and so on, are known to be far above those of Korean and up to one of the most advanced in the world. Thus it is thought to be necessary that the acquisition of these technologies, implementation of joint research projects for technology development as well as the balanced opportunities for commercial product/sales and cooperation should be actively pursued in order to enhance the levels of Korean technologies in these fields

  19. Student and Faculty Outcomes of Undergraduate Science Research Projects by Geographically Dispersed Students

    Science.gov (United States)

    Shaw, Lawton; Kennepohl, Dietmar

    2013-01-01

    Senior undergraduate research projects are important components of most undergraduate science degrees. The delivery of such projects in a distance education format is challenging. Athabasca University (AU) science project courses allow distance education students to complete research project courses by working with research supervisors in their…

  20. RESEARCH ON INCREASING INTEREST FOR BIOLOGY BY USING WORKSHEETS

    Directory of Open Access Journals (Sweden)

    Liliana Hildegarde MUNTEAN

    2012-01-01

    Full Text Available The school's responsibility is to promote the goals of society.Today the educators must look at teaching and learning in a different context because increases the need for innovative ways to incorporate an experiential approach into management courses. Most people tend to use one of their senses more than the others. In this study, the visual learning style is the most common. By using the worksheet in the teaching-learning-assessment increased students' interest for Biology. Differentiated support granted by the teacher gave better results than with traditional lessons.

  1. 2012 CELLULAR & MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 17 - 22, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Judith Berman

    2012-06-22

    The Gordon Research Conference on CELLULAR & MOLECULAR FUNGAL BIOLOGY was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  2. Thinking Big for 25 Years: Astronomy Camp Research Projects

    Science.gov (United States)

    Hooper, Eric Jon; McCarthy, D. W.; Benecchi, S. D.; Henry, T. J.; Kirkpatrick, J. D.; Kulesa, C.; Oey, M. S.; Regester, J.; Schlingman, W. M.; Camp Staff, Astronomy

    2013-01-01

    Astronomy Camp is a deep immersion educational adventure for teenagers and adults in southern Arizona that is entering its 25th year of existence. The Camp Director (McCarthy) is the winner of the 2012 AAS Education Prize. A general overview of the program is given in an accompanying contribution (McCarthy et al.). In this presentation we describe some of the research projects conducted by Astronomy Camp participants over the years. Many of the Camps contain a strong project-oriented emphasis, which reaches its pinnacle in the Advanced Camps for teenagers. High school students from around the world participate in a microcosm of the full arc of astronomy research. They plan their own projects before the start of Camp, and the staff provide a series of "key projects." Early in the Camp the students submit observing proposals to utilize time on telescopes. (The block of observing time is secured in advance by the staff.) The participants collect, reduce and analyze astronomical data with the help of staff, and they present the results to their peers on the last night of Camp, all in a span of eight days. The Camps provide research grade telescopes and instruments, in addition to amateur telescopes. Some of the Camps occur on Kitt Peak, where we use an ensemble of telescopes: the 2.3-meter (University of Arizona) with a spectrograph; the WIYN 0.9-meter; the McMath-Pierce Solar Telescope; and the 12-meter millimeter wave telescope. Additionally the Camp has one night on the 10-meter Submillimeter Telescope on Mt. Graham. Campers use these resources to study stars, galaxies, AGN, transiting planets, molecular clouds, etc. Some of the camper-initiated projects have led to very high level performances in prestigious international competitions, such as the Intel International Science and Engineering Fair. The key projects often contribute to published astronomical research (e.g., Benecchi et al. 2010, Icarus, 207, 978). Many former Campers have received Ph.D. degrees in

  3. Energy Efficient Community Development in California: Chula Vista Research Project

    Energy Technology Data Exchange (ETDEWEB)

    Gas Technology Institute

    2009-03-31

    In 2007, the U.S. Department of Energy joined the California Energy Commission in funding a project to begin to examine the technical, economic and institutional (policy and regulatory) aspects of energy-efficient community development. That research project was known as the Chula Vista Research Project for the host California community that co-sponsored the initiative. The researches proved that the strategic integration of the selected and economically viable buildings energy efficiency (EE) measures, photovoltaics (PV), distributed generation (DG), and district cooling can produce significant reductions in aggregate energy consumption, peak demand and emissions, compared to the developer/builder's proposed baseline approach. However, the central power plant emission reductions achieved through use of the EE-DG option would increase local air emissions. The electric and natural gas utility infrastructure impacts associated with the use of the EE and EE-PV options were deemed relatively insignificant while use of the EE-DG option would result in a significant reduction of necessary electric distribution facilities to serve a large-scale development project. The results of the Chula Vista project are detailed in three separate documents: (1) Energy-Efficient Community Development in California; Chula Vista Research Project report contains a detailed description of the research effort and findings. This includes the methodologies, and tools used and the analysis of the efficiency, economic and emissions impacts of alternative energy technology and community design options for two development sites. Research topics covered included: (a) Energy supply, demand, and control technologies and related strategies for structures; (b) Application of locally available renewable energy resources including solar thermal and PV technology and on-site power generation with heat recovery; (c) Integration of local energy resources into district energy systems and existing

  4. Remote Imaging Projects In Research And Astrophotography With Starpals

    Science.gov (United States)

    Fischer, Audrey; Kingan, J.

    2008-05-01

    StarPals is a nascent non-profit organization with the goal of providing opportunities for international collaboration between students of all ages within space science research. We believe that by encouraging an interest in the cosmos, the one thing that is truly Universal, from a young age, students will not only further their knowledge of and interest in science but will learn valuable teamwork and life skills. The goal is to foster respect, understanding and appreciation of cultural diversity among all StarPals participants, whether students, teachers, or mentors. StarPals aims to inspire students by providing opportunities in which, more than simply visualizing themselves as research scientists, they can actually become one. The technologies of robotic telescopes, videoconferencing, and online classrooms are expanding the possibilities like never before. In honor of IYA2009, StarPals would like to encourage 400 schools to participate on a global scale in astronomy/cosmology research on various concurrent projects. We will offer in-person or online workshops and training sessions to teach the teachers. We will be seeking publication in scientific journals for some student research. For our current project, the Double Stars Challenge, students use the robotic telescopes to take a series of four images of one of 30 double stars from a list furnished by the US Naval Observatory and then use MPO Canopus software to take distance and position angle measurements. StarPals provides students with hands-on training, telescope time, and software to complete the imaging and measuring. A paper will be drafted from our research data and submitted to the Journal of Double Star Observations. The kids who participate in this project may potentially be the youngest contributors to an article in a vetted scientific journal. Kids rapidly adapt and improve their computer skills operating these telescopes and discover for themselves that science is COOL!

  5. Ecological Footprint of Biological Resource Consumption in a Typical Area of the Green for Grain Project in Northwestern China

    Directory of Open Access Journals (Sweden)

    Jie Hu

    2015-01-01

    Full Text Available Following the implementation of the Green for Grain Project in 2000 in Guyuan, China, the decrease in cultivated land and subsequent increase in forest and grassland pose substantial challenges for the supply of biological products. Whether the current biologically productive land-use patterns in Guyuan satisfy the biological product requirements for local people is an urgent problem. In this study, the ecological footprints of biological resource consumption in Guyuan were calculated and analyzed based on the ‘City Hectare’ Ecological Footprint (EF Method. The EFs of different types of biological resource products consumed from different types of biologically productive land were then analyzed. In addition, the EFs of various biological resource products before and after the implementation of the Green for Grain Project (1998 and 2012 were assessed. The actual EF and bio-capacity (BC were compared, and differences in the EF and BC for different types of biologically productive lands before and after the project were analyzed. The results showed that the EF of Guyuan’s biological resource products was 0.65866 ha/cap, with an EF outflow and EF inflow of 0.2280 ha/cap and 0.0951 ha/cap, respectively. The per capita EF of Guyuan significantly decreased after the project, as did the ecological deficit. Whereas the cultivated land showed a deficit, grasslands were characterized by ecological surplus. The total EF of living resource consumption in Guyuan was 810,941 ha, and the total BC was 768,065 ha. In additional to current biological production areas, approximately 42,876 ha will be needed to satisfy the demands of Guyuan’s people. Cultivated land is the main type of biologically productive land that is needed.

  6. Northeast Cooperative Research Study Fleet (SF) Program Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Northeast Cooperative Research Study Fleet (SF) Program partners with a subset of commercial fishermen to collect high quality, high resolution, haul by haul...

  7. Systems biology in the frontier of cancer research:a report of the Second International Workshop of Cancer Systems Biology

    Institute of Scientific and Technical Information of China (English)

    Juan Cui; Yan-Chun Liang; Ying Xu

    2012-01-01

    The report summarizes the Second International Workshop of Cancer Systems Biology held on July 5-6,2012 in Changchun,China.The goal of the workshop was to bring together cancer researchers with different backgrounds to share their views about cancer and their experiences in fighting against cancer,and to gain new and systems-level understanding about cancer formation,progression,diagnosis,and treatment through exchanging ideas.

  8. Systems biology in the frontier of cancer research: a report of the Second International Workshop of Cancer Systems Biology

    OpenAIRE

    Ying Xu; Yan-Chun Liang; Juan Cui

    2012-01-01

    The report summarizes the Second International Workshop of Cancer Systems Biology held on July 5-6, 2012 in Changchun, China. The goal of the workshop was to bring together cancer researchers with different backgrounds to share their views about cancer and their experiences in fighting against cancer, and to gain new and systems-level understanding about cancer formation, progression, diagnosis, and treatment through exchanging ideas.

  9. Introduction to Oxidative Stress in Biomedical and Biological Research

    OpenAIRE

    Michael Breitenbach; Peter Eckl

    2015-01-01

    Oxidative stress is now a well-researched area with thousands of new articles appearing every year. We want to give the reader here an overview of the topics in biomedical and basic oxidative stress research which are covered by the authors of this thematic issue. We also want to give the newcomer a short introduction into some of the basic concepts, definitions and analytical procedures used in this field.

  10. Geochemical, hydrological, and biological cycling of energy residual. Research plan

    International Nuclear Information System (INIS)

    Proposed research goals and specific research areas designed to provide a base of fundamental scientific information so that the geochemical, hydrological, and biophysical mechanisms that contribute to the transport and long term fate of energy residuals in natural systems can be understood are described. Energy development and production have resulted in a need for advanced scientific information on the geochemical transformations, transport rates, and potential for bioaccumulation of contaminants in subsurface environments

  11. Engaging Students in Authentic Microbiology Research in an Introductory Biology Laboratory Course is Correlated with Gains in Student Understanding of the Nature of Authentic Research and Critical Thinking

    Directory of Open Access Journals (Sweden)

    Brittany J. Gasper

    2013-02-01

    Full Text Available Recent recommendations for biology education highlight the role of authentic research experiences early in undergraduate education as a means of increasing the number and quality of biology majors. These experiences will inform students on the nature of science, increase their confidence in doing science, as well as foster critical thinking skills, an area that has been lacking despite it being one of the desired outcomes at undergraduate institutions and with future employers. With these things in mind, we have developed an introductory biology laboratory course where students design and execute an authentic microbiology research project. Students in this course are assimilated into the community of researchers by engaging in scholarly activities such as participating in inquiry, reading scientific literature, and communicating findings in written and oral formats. After three iterations of a semester-long laboratory course, we found that students who took the course showed a significant increase in their understanding of the nature of authentic research and their level of critical thinking skills.

  12. Neutron Imaging at the Oak Ridge National Laboratory: Application to Biological Research

    Energy Technology Data Exchange (ETDEWEB)

    Bilheux, Hassina Z [ORNL; Cekanova, Maria [University of Tennessee, Knoxville (UTK); Bilheux, Jean-Christophe [ORNL; Bailey, William Barton [ORNL; Keener, Wylie S [ORNL; Davis, Larry E [ORNL; Herwig, Kenneth W [ORNL

    2014-01-01

    The Oak Ridge National Laboratory Neutron Sciences Directorate (NScD) has recently installed a neutron imaging beamline at the High Flux Isotope Reactor (HFIR) cold guide hall. The CG-1D beamline supports a broad range of user research spanning from engineering to material research, energy storage, additive manufacturing, vehicle technologies, archaeology, biology, and plant physiology. The beamline performance (spatial resolution, field of view, etc.) and its utilization for biological research are presented. The NScD is also considering a proposal to build the VENUS imaging beamline (beam port 10) at the Spallation Neutron Source (SNS). Unlike CG-1D which provides cold neutrons, VENUS will offer a broad range of neutron wavelengths, from epithermal to cold, and enhanced contrast mechanisms. This new capability will also enable the imaging of thicker biological samples than is currently available at CG-1D. A brief overview of the VENUS capability for biological research is discussed.

  13. Dermal tumorigen PAH and complex mixtures for biological research

    International Nuclear Information System (INIS)

    Thirteen commercially available, commonly reported four-five ring dermal tumorigen PAHs, were determined in a set of complex mixtures consisting of crude and upgraded coal liquids, and petroleum crude oils and their distillate fractions. Semi-preparative scale, normal phase high performance liquid chromatographic fractionation followed by capillary column gas chromatography or gas chromatography-mass spectroscopy were used for the measurements. Deuterated or carbon-14 labeled PAH served as internal standards or allowed recovery corrections. Approaches for the preparation and measurement of radiolabeled PAH were examined to provide chemical probes for biological study. Synthetic routes for production of 14C labeled dihydrobenzo[a]pyrene and 14C- or 3H 10-azabenzo[a]pyrene are being studied to provide tracers for fundamental studies in tracheal transplant and skin penetration systems. (DT)

  14. Research and development project report for FY 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-09-01

    This report summarizes results of research and development projects administered by NEDO for FY 1996. Overview of new energy projects and twelve chapters for individual projects are provided in the report. The new energy technology development projects administered by NEDO are classified into twelve categories, i.e., Development of technologies for solar energy utilization, Development of geothermal resources, Development of technologies for exploration and utilization of geothermal energy, Development of coal energy utilization technologies, Development of coal resources, Development of energy conversion and storage technologies, Development of hydrogen, alcohol and biomass technologies, Development of other oil-alternative energy technologies, Introduction and promotion of new energy sources, International energy-promotion activities, Promotion of development and introduction, and Activities of the NEDO Information Center. To ensure energy security and actively cope with environmental problems such as by taking carbon dioxide emission control measures, NEDO has stepped up its efforts to develop new energy- and energy saving-related technologies and introduce and diffuse them. 79 figs., 37 tabs.

  15. Management of Service Projects in Support of Space Flight Research

    Science.gov (United States)

    Love, J.

    2009-01-01

    Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.

  16. Progress of biological invasions research in China over the last decade

    OpenAIRE

    Chengjen Shih; Bo Li; Hui Li; Ruiting Ju

    2012-01-01

    As one of the five major global environmental problems, invasive species have posed serious threats to native ecosystems, public health, and regional economies. Although much progress has been madein the field of biological invasions research in China over the last decade, there are still large knowledge gaps. This paper reviews progress in the field of biological invasions research since 2000 as it relates to China, covering the diversity, colonization and immigration patterns of invasive sp...

  17. IAEA Assistance in the development of new research reactor projects

    International Nuclear Information System (INIS)

    A research reactor (RR) project is a major undertaking that requires careful preparation, planning, implementation and investment in time, money, and human resources. In recent years, the interest of IAEA Member States in developing RR programmes has grown significantly, and currently, several Member States are in different stages of new RR projects. The majority of these countries are building their first RR as a key national facility for the development of their nuclear science and technology programmes, including nuclear power. In order to support Member States in such efforts, the IAEA in 2012 published the Nuclear Energy Series Report No. NP-T-5.1 on Specific Considerations and Milestones for a Research Reactor Project. To provide further support, the IAEA also published a document to assist Member States in the preparation of the bid invitation specification for the purchase of a RR. The IAEA will also continue to provide assistance for human resources development of the Member States establishing their first RR, and to facilitate sharing experience and knowledge among Member States through its programmatic activities including expert mission services, technical meetings, training courses and workshops addressing relevant technical and safety topics. This paper presents the IAEA assistance and services provided to the Member States considering new RRs, with particular emphasis on those establishing their first RR, including elaboration on the services mentioned above.

  18. IAEA Assistance in the development of new research reactor projects

    Energy Technology Data Exchange (ETDEWEB)

    Borio di Tigliole, Andrea; Bradley, Ed; Zhukova, Anastasia; Adelfang, Pablo [International Atomic Energy Agency, Research Reactor Section, Vienna (Austria); Shokr, Amgad [International Atomic Energy Agency, Research Reactor Safety Section, Vienna (Austria); Ridikas, Danas [International Atomic Energy Agency, Physics Section, Vienna (Austria)

    2015-08-15

    A research reactor (RR) project is a major undertaking that requires careful preparation, planning, implementation and investment in time, money, and human resources. In recent years, the interest of IAEA Member States in developing RR programmes has grown significantly, and currently, several Member States are in different stages of new RR projects. The majority of these countries are building their first RR as a key national facility for the development of their nuclear science and technology programmes, including nuclear power. In order to support Member States in such efforts, the IAEA in 2012 published the Nuclear Energy Series Report No. NP-T-5.1 on Specific Considerations and Milestones for a Research Reactor Project. To provide further support, the IAEA also published a document to assist Member States in the preparation of the bid invitation specification for the purchase of a RR. The IAEA will also continue to provide assistance for human resources development of the Member States establishing their first RR, and to facilitate sharing experience and knowledge among Member States through its programmatic activities including expert mission services, technical meetings, training courses and workshops addressing relevant technical and safety topics. This paper presents the IAEA assistance and services provided to the Member States considering new RRs, with particular emphasis on those establishing their first RR, including elaboration on the services mentioned above.

  19. Energy crop research advances the fundamentals of forest biology

    Energy Technology Data Exchange (ETDEWEB)

    Layton, P.A.; Wright, L.L.

    1987-01-01

    The Short Rotation Woody Crops Program sponsors research on tree and crop physiology, genetic improvement, and biotechnology. Genetic improvement of cottonwoods (Populus spp.) has produced clones with average yields of 25 dry Mg/ha/y. Physiological research on cottonwoods and their hybrids have shown that the hybrids were intermediate to their parental types in many characteristics. The goal of this research is to identify individual traits contributing to enhanced growth and to genetically improve these traits. The biotechnological goal is to develop herbicide and pest-resistant hybrid poplars. Models have been developed to describe both individual and stand growth in an effort to determine productivity and identify tree ideotypes that grow well in short-rotation intensive culture systems.

  20. Project 'European Research Center for Air Pollution Abatement Measures'

    International Nuclear Information System (INIS)

    During the 5-7th of March 1985 the first status report of the project 'European Research Center for Air Pollution Control Measures' took place in the Nuclear Research Center, Karlsruhe. Progress reports on the following topics assessment and analysis of the impacts of airborne pollutants on forest trees; distinction from other potential causes of recent forest dieback, research into atmospheric dispersion, conversion and deposition of airborne pollutants, development and optimization of industrial-technical processes to reduce or avoid emissions and providing instruments and making recommendations to the industrial and political sectors were presented. This volume is a collection of the work reported there. 42 papers were entered separately. (orig./MG)

  1. The International Satellite Cloud Climatology Project (ISCCP) - The first project of the World Climate Research Programme

    Science.gov (United States)

    Schiffer, R. A.; Rossow, W. B.

    1983-01-01

    The first project of the World Climate Research Program is the International Satellite Cloud Climatology Project, (ISCCP) whose objective is the collection and analysis of satellite radiance data in order to infer the global distribution of cloud radiative properties and improve the modeling of cloud effects on climate. The operational component of ISCCP takes advantage of the global coverage provided by the current and planned international array of geostationary and polar-orbiting meteorological satellites in the 1980s. It will produce a five-year global radiance and cloud data set. The research component of ISCCP will coordinate studies to validate climatology, improve cloud analysis algorithms, improve cloud effects modelling, and investigate the role of clouds in the atmospheric radiation budget and hydrologic cycle.

  2. Using Facebook to Supplement Participant Pools for Class Research Projects: Should We Like It?

    Science.gov (United States)

    Sciutto, Mark J.

    2015-01-01

    In-class research projects are a valuable way of providing research experience for undergraduate students in psychology. This article evaluates the use of online social networks to supplement sample recruitment for in-class research projects. Specifically, this article presents a systematic analysis of seven student research projects that…

  3. The trajectory of dispersal research in conservation biology. Systematic review.

    Science.gov (United States)

    Driscoll, Don A; Banks, Sam C; Barton, Philip S; Ikin, Karen; Lentini, Pia; Lindenmayer, David B; Smith, Annabel L; Berry, Laurence E; Burns, Emma L; Edworthy, Amanda; Evans, Maldwyn J; Gibson, Rebecca; Heinsohn, Rob; Howland, Brett; Kay, Geoff; Munro, Nicola; Scheele, Ben C; Stirnemann, Ingrid; Stojanovic, Dejan; Sweaney, Nici; Villaseñor, Nélida R; Westgate, Martin J

    2014-01-01

    Dispersal knowledge is essential for conservation management, and demand is growing. But are we accumulating dispersal knowledge at a pace that can meet the demand? To answer this question we tested for changes in dispersal data collection and use over time. Our systematic review of 655 conservation-related publications compared five topics: climate change, habitat restoration, population viability analysis, land planning (systematic conservation planning) and invasive species. We analysed temporal changes in the: (i) questions asked by dispersal-related research; (ii) methods used to study dispersal; (iii) the quality of dispersal data; (iv) extent that dispersal knowledge is lacking, and; (v) likely consequences of limited dispersal knowledge. Research questions have changed little over time; the same problems examined in the 1990s are still being addressed. The most common methods used to study dispersal were occupancy data, expert opinion and modelling, which often provided indirect, low quality information about dispersal. Although use of genetics for estimating dispersal has increased, new ecological and genetic methods for measuring dispersal are not yet widely adopted. Almost half of the papers identified knowledge gaps related to dispersal. Limited dispersal knowledge often made it impossible to discover ecological processes or compromised conservation outcomes. The quality of dispersal data used in climate change research has increased since the 1990s. In comparison, restoration ecology inadequately addresses large-scale process, whilst the gap between knowledge accumulation and growth in applications may be increasing in land planning. To overcome apparent stagnation in collection and use of dispersal knowledge, researchers need to: (i) improve the quality of available data using new approaches; (ii) understand the complementarities of different methods and; (iii) define the value of different kinds of dispersal information for supporting management

  4. The trajectory of dispersal research in conservation biology. Systematic review.

    Directory of Open Access Journals (Sweden)

    Don A Driscoll

    Full Text Available Dispersal knowledge is essential for conservation management, and demand is growing. But are we accumulating dispersal knowledge at a pace that can meet the demand? To answer this question we tested for changes in dispersal data collection and use over time. Our systematic review of 655 conservation-related publications compared five topics: climate change, habitat restoration, population viability analysis, land planning (systematic conservation planning and invasive species. We analysed temporal changes in the: (i questions asked by dispersal-related research; (ii methods used to study dispersal; (iii the quality of dispersal data; (iv extent that dispersal knowledge is lacking, and; (v likely consequences of limited dispersal knowledge. Research questions have changed little over time; the same problems examined in the 1990s are still being addressed. The most common methods used to study dispersal were occupancy data, expert opinion and modelling, which often provided indirect, low quality information about dispersal. Although use of genetics for estimating dispersal has increased, new ecological and genetic methods for measuring dispersal are not yet widely adopted. Almost half of the papers identified knowledge gaps related to dispersal. Limited dispersal knowledge often made it impossible to discover ecological processes or compromised conservation outcomes. The quality of dispersal data used in climate change research has increased since the 1990s. In comparison, restoration ecology inadequately addresses large-scale process, whilst the gap between knowledge accumulation and growth in applications may be increasing in land planning. To overcome apparent stagnation in collection and use of dispersal knowledge, researchers need to: (i improve the quality of available data using new approaches; (ii understand the complementarities of different methods and; (iii define the value of different kinds of dispersal information for supporting

  5. European fusion energy research and international ITER project

    International Nuclear Information System (INIS)

    The scientific feasibility of fusion energy has been demonstrated in recent tokamak experiments in Europe, Japan and the United States. The basic features of the confinement of high temperature hydrogen plasmas by strong magnetic fields are reasonably well understood, which creates a high level of confidence in the performance of the next step fusion devices. The most powerful fusion device in the world is the Joint European Torus (JET), which has ensured the European Fusion Programme its leading position in international fusion research. The nest step fusion reactor, ITER (International Thermonuclear Experimental Reactor), is an international project involving the cooperation of the European Union, Japan, The Russian Federation and USA. The overall objective of ITER is to demonstrate the scientific and technological feasibility of fusion power for peaceful purposes. Membership in the European Union would automatically make Finland a participant in the Community Fusion Programme and the international ITER project. (orig.)

  6. DECOVALEX. An international collaborative research project on radioactive waste disposal

    International Nuclear Information System (INIS)

    The creation of huge quantities of high-level, long-lived radioactive waste is the most formidable problem facing the nuclear power industry today in the world. However, achieving safe storage of radioactive wastes so that they will not endanger biosphere environment is a great challenge. With supports and participation of national radioactive waste management agencies and/or regulatory bodies from USA, Canada, Japan, Korea, China, Finland, Sweden, Germany, France, Spain, UK and Czech, an international collaborative research project, DECOVALEX, was initiated in 1992 and has continued up to today. The primary objective of this project is to evaluate if the nuclear waste can be stored safely in a geological repository of a multi-barrier system. (author)

  7. MIT LMFBR blanket research project. Final summary report

    Energy Technology Data Exchange (ETDEWEB)

    Driscoll, M.J.

    1983-08-01

    This is a final summary report on an experimental and analytical program for the investigation of LMFBR blanket characteristics carried out at MIT in the period 1969 to 1983. During this span of time, work was carried out on a wide range of subtasks, ranging from neutronic and photonic measurements in mockups of blankets using the Blanket Test Facility at the MIT Research Reactor, to analytic/numerical investigations of blanket design and economics. The main function of this report is to serve as a resource document which will permit ready reference to the more detailed topical reports and theses issued over the years on the various aspects of project activities. In addition, one aspect of work completed during the final year of the project, on doubly-heterogeneous blanket configurations, is documented for the record.

  8. MIT LMFBR blanket research project. Final summary report

    International Nuclear Information System (INIS)

    This is a final summary report on an experimental and analytical program for the investigation of LMFBR blanket characteristics carried out at MIT in the period 1969 to 1983. During this span of time, work was carried out on a wide range of subtasks, ranging from neutronic and photonic measurements in mockups of blankets using the Blanket Test Facility at the MIT Research Reactor, to analytic/numerical investigations of blanket design and economics. The main function of this report is to serve as a resource document which will permit ready reference to the more detailed topical reports and theses issued over the years on the various aspects of project activities. In addition, one aspect of work completed during the final year of the project, on doubly-heterogeneous blanket configurations, is documented for the record

  9. Summaries of the Idaho National Engineering Laboratory Radioecology and Ecology Program research projects

    International Nuclear Information System (INIS)

    This report provides summaries of individual research projects conducted by the Idaho National Engineering Laboratory Radioecology and Ecology Program. Summaries include projects in various stages, from those that are just beginning, to projects that are in the final publication stage

  10. Polyhydroyalkanoates: from Basic Research and Molecular Biology to Application

    Directory of Open Access Journals (Sweden)

    Amro Abd alFattah Amara

    2010-09-01

    Full Text Available This review describes the Polyhydroxyalkanoate (PHA, an intracellular biodegradable microbial polymer. PHAs is formed from different types of three hydroxyalkanoic acids monomers, each unit forms an ester bond with the hydroxyl group of the other one and the hydroxyl substituted carbon has R configuration. The C-3 atom in β position is branched with at least one carbon atom in the form of methyl group (C1 to thirteen carbons in the form of tridecyl (C13. This alkyl side chain is not necessarily saturated. PHAs are biosynthesized through regulated pathways by specific enzymes. PHAs are accumulated in bacterial cells from soluble to insoluble form as storage materials inside the inclusion bodies during unbalanced nutrition or to save organisms from reducing equivalents. PHAs are converted again to soluble components by PHAs depolymerases and the degraded materials enter various metabolic pathways. Until now, four classes of enzymes responsible for PHAs polymerization are known. PHAs were well studied regarding their promising applications, physical, chemical and biological properties. PHAs are biodegradable, biocompatible, have good material properties, renewable and can be used in many applications. The most limiting factor in PHAs commercialization is their high cost compared to the petroleum plastics. This review highlights the new knowledge and that established by the pioneers in this field as well as the factors, which affect PHAs commercialization.

  11. Challenges in Doctoral Research Project Management: A Comparative Study

    Directory of Open Access Journals (Sweden)

    Reuven Katz

    2016-03-01

    Full Text Available This paper presents quantitative results of a comparative study evaluating the management skills of doctoral candidates working toward a PhD and additional information related to their lifestyles. We conducted a survey among enrolled doctoral candidates at five universities in Israel and three technological universities in Western Europe. 1013 Israeli candidates and 457 Western European candidates replied to our survey. In our analysis, we compared the answers of Israeli Science and Engineering candidates to those of Social Sciences and Humanities candidates; in addition, we compared the answers of Israeli Science and Engineering students to their Western European peers. Our analysis focused on finding significant patterns by comparing these groups of students. In order to identify such patterns, we analyzed each question using the Pearson chi-square test. The current study’s main finding is that the majority of candidates, regardless of their chosen academic field or the region where they study, have no training or expertise in managing a doctoral research project. Based on these findings, we suggest that all doctoral candidates be taught basic research-project management. We believe that such training will provide them with a powerful tool for better managing their research as they advance towards successful completion of their doctorate.

  12. Radiation protection research projects. Status report 2007; Strahlenschutzforschung. Programmreport 2007

    Energy Technology Data Exchange (ETDEWEB)

    Bernhard-Stroel, Claudia; Goedde, Ralph; Hachenberger, Claudia; Loebke-Reinl, Angelika; Schmitt-Hannig, Annemarie

    2009-01-15

    In Behalf of the German Federal Environment Ministry (BMU) the BfS (Bundesamt fuer Strahlenschutz) assigns research contracts concerning radiation protection topics. The results of these research projects are supposed to provide decision support for the development of radiation protection regulations and other specific radiation protection tasks of the BMU. The BfS is basically charged for the planning, the technical and administrative prearrangements, the assignment, the expert monitoring and the technical evaluation of the results. The report is the compiled information on the results or intermediate results (status reports) of these research projects for the year 2007. [German] Das Bundesamt fuer Strahlenschutz (BfS) vergibt im Auftrag des Bundesministeriums fuer Umwelt, Naturschutz und Reaktorsicherheit (BMU) Forschungsvorhaben auf dem Gebiet des Strahlenschutzes. Die Ergebnisse dieser Vorhaben dienen als Entscheidungshilfen bei der Erarbeitung von Strahlenschutzvorschriften und bei der Erfuellung sonstiger Fachaufgaben des BMU im Bereich Strahlenschutz. Die Planung, fachliche und administrative Vorbereitung, Vergabe, Begleitung sowie die fachliche Bewertung der Ergebnisse der Untersuchungsvorhaben ist grundsaetzlich Aufgabe des Bundesamtes fuer Strahlenschutz. Der vorliegende Bericht informiert ueber die Ergebnisse bzw. Zwischenergebnisse (in Form von Statusberichten) von Strahlenschutzvorhaben des BMU-Ressortforschungsprogramms im Jahr 2007. (orig.)

  13. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  14. Inventory of Federal energy-related environment and safety research for FY 1977. Volume II. Project listings

    Energy Technology Data Exchange (ETDEWEB)

    1978-07-01

    This volume contains Biomedical and Environmental Research, Environmental Control Technology Research, and Operational and Environmental Safety Research project listings. The projects are ordered numerically by log number.

  15. 76 FR 15964 - Funding Priorities: Disability and Rehabilitation Research Projects and Centers Program

    Science.gov (United States)

    2011-03-22

    ... Funding Priorities: Disability and Rehabilitation Research Projects and Centers Program AGENCY: Office of... funding priorities for the Disability and Rehabilitation Research Projects and Centers Program... best strategies and programs to improve rehabilitation outcomes for underserved populations;...

  16. Group-effort applied research: expanding opportunities for undergraduate research through original, class-based research projects.

    Science.gov (United States)

    Moore, Sean D; Teter, Ken

    2014-01-01

    Undergraduate research clearly enriches the educational development of participating students, but these experiences are limited by the inherent inefficiency of the standard one student-one mentor model for undergraduate research. Group-effort applied research (GEAR) was developed as a strategy to provide substantial numbers of undergraduates with meaningful research experiences. The GEAR curriculum delivers concept-driven lecture material and provides hands-on training in the context of an active research project from the instructor's laboratory. Because GEAR is structured as a class, participating students benefit from intensive, supervised research training that involves a built-in network of peer support and abundant contact with faculty mentors. The class format also ensures a relatively standardized and consistent research experience. Furthermore, meaningful progress toward a research objective can be achieved more readily with GEAR than with the traditional one student-one mentor model of undergraduate research because sporadic mistakes by individuals in the class are overshadowed by the successes of the group as a whole. Three separate GEAR classes involving three distinct research projects have been offered to date. In this article, we provide an overview of the GEAR format and review some of the recurring themes for GEAR instruction. We propose GEAR can serve as a template to expand student opportunities for life science research without sacrificing the quality of the mentored research experience.

  17. The role of research and researchers in integrative and participatory projects

    NARCIS (Netherlands)

    Tress, G.; Tress, B.; Bloemmen, M.H.I.

    2003-01-01

    The previous chapters reflect on knowledge production and how to move from tacit to explicit knowledge in integrative and particpatory projects in the fields of landscape research and planning. This chapter takes the opportunity to draw some conclusions of a more general nature

  18. Registry of Communication Research: An Identification of Selected Communication Research Projects in the Academic Community.

    Science.gov (United States)

    Smith, Elbert J., Ed.

    This Registry is designed to be a single-source reference to aid in determining the kinds of communication research in process, where it is being conducted, and by whom. The projects are categorized by one or more primary areas of communication and then as to the most applicable basic form of communication. Basic areas of communication research…

  19. Web-based communication tools in a European research project: the example of the TRACE project

    Directory of Open Access Journals (Sweden)

    Baeten V.

    2009-01-01

    Full Text Available The multi-disciplinary and international nature of large European projects requires powerful managerial and communicative tools to ensure the transmission of information to the end-users. One such project is TRACE entitled “Tracing Food Commodities in Europe”. One of its objectives is to provide a communication system dedicated to be the central source of information on food authenticity and traceability in Europe. This paper explores the web tools used and communication vehicles offered to scientists involved in the TRACE project to communicate internally as well as to the public. Two main tools have been built: an Intranet and a public website. The TRACE website can be accessed at http://www.trace.eu.org. A particular emphasis was placed on the efficiency, the relevance and the accessibility of the information, the publicity of the website as well as the use of the collaborative utilities. The rationale of web space design as well as integration of proprietary software solutions are presented. Perspectives on the using of web tools in the research projects are discussed.

  20. The NYC native air sampling pilot project: using HVAC filter data for urban biological incident characterization.

    Science.gov (United States)

    Ackelsberg, Joel; Leykam, Frederic M; Hazi, Yair; Madsen, Larry C; West, Todd H; Faltesek, Anthony; Henderson, Gavin D; Henderson, Christopher L; Leighton, Terrance

    2011-09-01

    Native air sampling (NAS) is distinguished from dedicated air sampling (DAS) devices (eg, BioWatch) that are deployed to detect aerosol disseminations of biological threat agents. NAS uses filter samples from heating, ventilation, and air conditioning (HVAC) systems in commercial properties for environmental sampling after DAS detection of biological threat agent incidents. It represents an untapped, scientifically sound, efficient, widely distributed, and comparably inexpensive resource for postevent environmental sampling. Calculations predict that postevent NAS would be more efficient than environmental surface sampling by orders of magnitude. HVAC filter samples could be collected from pre-identified surrounding NAS facilities to corroborate the DAS alarm and delineate the path taken by the bioaerosol plume. The New York City (NYC) Native Air Sampling Pilot Project explored whether native air sampling would be acceptable to private sector stakeholders and could be implemented successfully in NYC. Building trade associations facilitated outreach to and discussions with property owners and managers, who expedited contact with building managers of candidate NAS properties that they managed or owned. Nominal NAS building requirements were determined; procedures to identify and evaluate candidate NAS facilities were developed; data collection tools and other resources were designed and used to expedite candidate NAS building selection and evaluation in Manhattan; and exemplar environmental sampling playbooks for emergency responders were completed. In this sample, modern buildings with single or few corporate tenants were the best NAS candidate facilities. The Pilot Project successfully demonstrated that in one urban setting a native air sampling strategy could be implemented with effective public-private collaboration.

  1. Discussions about Management of Scientific Research Projects in Agricultural Research Institutes: A Case Study of EPPI of CATAS

    OpenAIRE

    CHU, Xiaoqiang; QIN, Hanchun; SHAN, Guoyan; LIN, Peiqun; HUANG, Guixiu

    2015-01-01

    Taking Environment and Plant Protection Institute in Chinese Academy of Tropical Agricultural Sciences as an example, it summarized major experience and practice in management of scientific research projects from strengthening project database, enhancing project planning, reinforcing scientific research management team construction, bringing into play functions of academies and institutes, and improving management system. It analyzed existing problems and came up with recommendations from str...

  2. Aespoe hard rock laboratory. Current research projects 1998

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-12-31

    In 1986 SKB decided to construct the Aespoe Hard Rock Laboratory (HRL) in order to provide an opportunity for research, development and demonstration in a realistic and undisturbed underground rock environment down to the depth planned for the future deep repository. The focus of current and future work is on development and testing of site characterization methods, verification of models describing the function of the natural and engineered barriers and development, testing, and demonstration of repository technology. The program has been organised so that all important steps in the development of a repository are covered, in other words the Aespoe HRL constitutes a `dress rehearsal` for the Swedish deep geological repository for spent fuel and other long-lived waste. Geoscientific investigations on Aespoe and nearby islands began in 1986. Aespoe was selected as the site for the laboratory in 1988. Construction of the facility, which reaches a depth of 460 m below the surface, began in 1990 and was completed in 1995. A major milestone had been reached in 1996 with the completion of the pre-investigation and construction phases of the Aespoe HRL. The comprehensive research conducted has permitted valuable development and verification of site characterization methods applied from the ground surface, boreholes, and underground excavations. The results of this research are summarised in the book `Aespoe Hard Rock Laboratory - 10 years of Research` published by SKB in 1996. The Operating Phase of the Aespoe HRL began in 1995 and is expected to continue for 15-20 years, that is until the first stage of the development of the Swedish deep geological repository for spent nuclear fuel is expected to be completed. A number of research projects were initiated at the start of the Operating Phase. Most of these projects have made substantial progress since then and important results have been obtained. The purpose of this brochure is to provide a brief presentation of the

  3. Aespoe hard rock laboratory. Current research projects 1998

    International Nuclear Information System (INIS)

    In 1986 SKB decided to construct the Aespoe Hard Rock Laboratory (HRL) in order to provide an opportunity for research, development and demonstration in a realistic and undisturbed underground rock environment down to the depth planned for the future deep repository. The focus of current and future work is on development and testing of site characterization methods, verification of models describing the function of the natural and engineered barriers and development, testing, and demonstration of repository technology. The program has been organised so that all important steps in the development of a repository are covered, in other words the Aespoe HRL constitutes a 'dress rehearsal' for the Swedish deep geological repository for spent fuel and other long-lived waste. Geoscientific investigations on Aespoe and nearby islands began in 1986. Aespoe was selected as the site for the laboratory in 1988. Construction of the facility, which reaches a depth of 460 m below the surface, began in 1990 and was completed in 1995. A major milestone had been reached in 1996 with the completion of the pre-investigation and construction phases of the Aespoe HRL. The comprehensive research conducted has permitted valuable development and verification of site characterization methods applied from the ground surface, boreholes, and underground excavations. The results of this research are summarised in the book 'Aespoe Hard Rock Laboratory - 10 years of Research' published by SKB in 1996. The Operating Phase of the Aespoe HRL began in 1995 and is expected to continue for 15-20 years, that is until the first stage of the development of the Swedish deep geological repository for spent nuclear fuel is expected to be completed. A number of research projects were initiated at the start of the Operating Phase. Most of these projects have made substantial progress since then and important results have been obtained. The purpose of this brochure is to provide a brief presentation of the

  4. Discussions about Management of Scientific Research Projects in Agricultural Research Institutes: A Case Study of EPPI of CATAS

    Institute of Scientific and Technical Information of China (English)

    Xiaoqiang; CHU; Hanchun; QIN; Guoyan; SHAN; Peiqun; LIN; Guixiu; HUANG

    2015-01-01

    Taking Environment and Plant Protection Institute in Chinese Academy of Tropical Agricultural Sciences as an example,it summarized major experience and practice in management of scientific research projects from strengthening project database,enhancing project planning,reinforcing scientific research management team construction,bringing into play functions of academies and institutes,and improving management system. It analyzed existing problems and came up with recommendations from strengthening project process management,improving management team quality,and improving incentive mechanism,in the hope of providing reference for scientific research project management in agricultural scientific research institutes.

  5. Overcoming the Newtonian paradigm: the unfinished project of theoretical biology from a Schellingian perspective.

    Science.gov (United States)

    Gare, Arran

    2013-09-01

    Defending Robert Rosen's claim that in every confrontation between physics and biology it is physics that has always had to give ground, it is shown that many of the most important advances in mathematics and physics over the last two centuries have followed from Schelling's demand for a new physics that could make the emergence of life intelligible. Consequently, while reductionism prevails in biology, many biophysicists are resolutely anti-reductionist. This history is used to identify and defend a fragmented but progressive tradition of anti-reductionist biomathematics. It is shown that the mathematico-physico-chemical morphology research program, the biosemiotics movement, and the relational biology of Rosen, although they have developed independently of each other, are built on and advance this anti-reductionist tradition of thought. It is suggested that understanding this history and its relationship to the broader history of post-Newtonian science could provide guidance for and justify both the integration of these strands and radically new work in post-reductionist biomathematics.

  6. Fiscal 1998 achievement report on regional consortium research and development project. Regional consortium of venture business fostering type--Creation of key industries (Development of technologies for manufacturing and utilizing various biological regulatory substances using Hokkaido-produced biomasses as materials); 1998 nendo Dosan biomass wo genryo to shita kakushu seitai chosetsu kino busshitsu no seisan riyo gijutsu kaihatsu seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-03-01

    The efforts aim to meet consumers' needs for products that will prevent lifestyle diseases or the like. For this purpose, substances answering the purpose are extracted from Hokkaido-produced agricultural and aquatic biomasses, and prepared for testing. Researches are conducted on how they behave in the enzyme, cell, and biological systems, and active substances are isolated and identified. In relation to the aquatic biomass, a technology is established of extracting and separating DHA (docosahexaenoic acid), EPA (eicosapentaenoic acid), taurine, etc., which are multivalent unsaturated fatty acids effective in preventing lifestyle diseases, from the unused parts of the squid. In relation to the agricultural biomass, antimicrobial active substances are extracted and separated from small fruit plants such as the chicory. Long-keeping foods are tentatively produced by the addition of dried powder of the chicory root tuber. In the elucidation of various biological regulatory substances contained in the Hokkaido-produced biomasses, they are tested for their abilities to resist microbes and active oxygen. Furthermore, verification tests are conducted by administering the substances to the senescence-accelerated mouse (SAM). (NEDO)

  7. THE CARE PROJECT - Coordinated Accelerator Research in Europe

    CERN Multimedia

    2003-01-01

    A one-day presentation of the project will take place on Monday February 10th in the CERN Council Chamber. The meeting will start a 9am and is expected to end at 4:30pm. The meeting, which is open to the whole community, will present an initiative on accelerator R&D in Europe, supported by ECFA, with the aim to bid for European Union support through the Framework 6 scheme. This initiative is coordinated by a steering group (ESGARD - European Steering Group on Accelerator Research and Development), which has been set up to coordinate European efforts on accelerator R&D and the submission of such bids. The initial bids have to be submitted by April 15th. All those interested in accelerator R&D are welcome to attend. Presentation of the CARE project (Coordinated Accelerator Research in Europe) to be submitted within FP6 February 10th, at CERN in the council room Agenda Chair : C. Wyss 9:00 General presentation of FP6 and introduction of IA proposal (R. Aleksan) 9:45 Networking activities on e ...

  8. Research of resisting of the biological active point for constant and alternative current

    Directory of Open Access Journals (Sweden)

    S. N. Peregudov

    2008-05-01

    Full Text Available Is conducted research of resistance of biologically active point (BAT on a direct and variable current. Research results are presented. The estimation of intercommunication between resistance of skin and by an electromagnetic radiation in BAT is done. Is shown possibility of the use of experimental information for diagnostics of the state of human to the organism.

  9. 75 FR 6401 - Medical Devices Regulated by the Center for Biologics Evaluation and Research; Availability of...

    Science.gov (United States)

    2010-02-09

    ... Evaluation and Research; Availability of Summaries of Safety and Effectiveness Data for Premarket Approval... safety and effectiveness data to the Division of Dockets Management (HFA-305), Food and Drug... the Center for Biologics Evaluation and Research (CBER). This list is intended to inform the public...

  10. Highly Adaptable but Not Invulnerable: Necessary and Facilitating Conditions for Research in Evolutionary Developmental Biology

    NARCIS (Netherlands)

    Laudel, Grit; Benninghoff, Martin; Lettkemann, Eric; Håkansson, Elias; Whitley, Richard; Gläser, Jochen

    2014-01-01

    Evolutionary developmental biology is a highly variable scientific innovation because researchers can adapt their involvement in the innovation to the opportunities provided by their environment. On the basis of comparative case studies in four countries, we link epistemic properties of research tas

  11. Redefining Authentic Research Experiences in Introductory Biology Laboratories and Barriers to Their Implementation

    Science.gov (United States)

    Spell, Rachelle M.; Guinan, Judith A.; Miller, Kristen R.; Beck, Christopher W.

    2014-01-01

    Incorporating authentic research experiences in introductory biology laboratory classes would greatly expand the number of students exposed to the excitement of discovery and the rigor of the scientific process. However, the essential components of an authentic research experience and the barriers to their implementation in laboratory classes are…

  12. The Start-Up Phase in a Research and Development Work Project: A Foundation for Development

    Science.gov (United States)

    Postholm, May Britt

    2008-01-01

    The article is based on a research and development work project (R&D project) conducted in a Norwegian lower secondary school. The purpose of the text is to describe the researchers' and teachers' roles during the initial phase of such a project, and what this phase and the close cooperation between the researcher and teachers mean for the…

  13. Xenopus laevis - A success story in biological research in Space

    Science.gov (United States)

    Horn, E.

    A feature of sensory, neuronal and motor systems is the existence of a critical period during their development. Environmental modifications, in particular stimulus depri-vation, during this period of life affects development in a long-term manner. For gravity sensory systems, space flights offer the only opportunity for deprivation conditions. Studies in the amphibian Xenopus laevis presented the most complete picture. The presentation demonstrates the importance of Xenopus laevis as an ex-perimental model animal in the past and even for future research in Space. Studies are presented which range from fertilization in Space and anatomical studies during early development under weightlessness up to post-flight studies on the anatomy of the peripheral sense organ, the spinal motor activity and behavior. Gravity depriva-tion induces anatomical as well as behavioral and neurophysiological modifications, which are normalized either during flight (thickening of the blastocoel roof) or after reentry in 1g-conditions (swimming and reflex behavior, spinal motor activity). The physiological changes can be explained by mechanisms of physiological adaptation. However, the studies also revealed stages which were insensitive to gravity depriva-tion; they point to the existence of a critical period. Observations on morphological mal-formations are described which are reversible after termination of microgravity and which are linked to a depression of vestibular reflex behavior. They might be caused by a competition between dorsalization and ventralization inducing growth factors. This observation offers the possibility for a genetic approach in finding ba-sics for microgravity effects on the development of Xenopus, and in a general frame, on the development of vertebrates including men. At the present stage of research, it remains open whether adaptive processes during exposure to altered gravity or the existence of a critical period in vestibular development are responsible for

  14. Research and engineering assessment of biological solubilization of phosphate

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, R.D.; McIlwain, M.E.; Losinski, S.J.; Taylor, D.D.

    1993-03-01

    This research and engineering assessment examined a microbial phosphate solubilization process as a method of recovering phosphate from phosphorus containing ore compared to the existing wet acid and electric arc methods. A total of 860 microbial isolates, collected from a range of natural environments were tested for their ability to solubilize phosphate from rock phosphate. A bacterium (Pseudomonas cepacia) was selected for extensive characterization and evaluation of the mechanism of phosphate solubilization and of process engineering parameters necessary to recover phosphate from rock phosphate. These studies found that concentration of hydrogen ion and production of organic acids arising from oxidation of the carbon source facilitated microbial solubilization of both pure chemical insoluble phosphate compounds and phosphate rock. Genetic studies found that phosphate solubilization was linked to an enzyme system (glucose dehydrogenase). Process-related studies found that a critical solids density of 1% by weight (ore to liquid) was necessary for optimal solubilization. An engineering analysis evaluated the cost and energy requirements for a 2 million ton per year sized plant, whose size was selected to be comparable to existing wet acid plants.

  15. 2012 PLANT MOLECULAR BIOLOGY GORDON RESEARCH CONFERENCE, JULY 15-20, 2012

    Energy Technology Data Exchange (ETDEWEB)

    Sussman, Michael

    2013-07-20

    The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

  16. Scientist-teacher collaboration: Integration of real data from a coastal wetland into a high school life science ecology-based research project

    Science.gov (United States)

    Hagan, Wendy L.

    Project G.R.O.W. is an ecology-based research project developed for high school biology students. The curriculum was designed based on how students learn and awareness of the nature of science and scientific practices so that students would design and carry out scientific investigations using real data from a local coastal wetland. This was a scientist-teacher collaboration between a CSULB biologist and high school biology teacher. Prior to implementing the three-week research project, students had multiple opportunities to practice building requisite skills via 55 lessons focusing on the nature of science, scientific practices, technology, Common Core State Standards of reading, writing, listening and speaking, and Next Generation Science Standards. Project G.R.O.W. culminated with student generated research papers and oral presentations. Outcomes reveal students struggle with constructing explanations and the use of Excel to create meaningful graphs. They showed gains in data organization, analysis, teamwork and aspects of the nature of science.

  17. Research plan: geochemical, hydrological and biological cycling of energy residuals. Subsurface Transport Program

    International Nuclear Information System (INIS)

    Energy development and production, particularly the generation of various waste products, have resulted in a need for long term scientific information on the geochemical transformations, transport rates, and potential for bioaccumulation or biotransformation of contaminants in subsurface environments. This plan describes proposed research goals and specific research directions intended to address these scientific questions. Research needs are grouped into three areas: (1) biogeo-chemical mobilization; (2) hydrological transport in subsurface systems; and (3) biological uptake and food chain transfer

  18. Geochemical, hydrological and biological cycling of energy residuals. Research plan: Subsurface Transport Program. Revision

    International Nuclear Information System (INIS)

    Energy development and production, particularly the generation of various waste products, have resulted in a need for long-term scientific information on the geochemical transformations, transport rates, and potential for bioaccumulation or biotransformation of contaminants in subsurface environments. This plan describes proposed research goals and specific research directions intended to address these scientific questions. Research needs are grouped into three areas: (1) biogeochemical mobilization; (2) hydrological transport in subsurface systems; and (3) biological uptake and food chain transfer

  19. Collaborative Research. Fundamental Science of Low Temperature Plasma-Biological Material Interactions

    Energy Technology Data Exchange (ETDEWEB)

    Graves, David Barry [Univ. California, Berkeley, CA (United States); Oehrlein, Gottlieb [Univ. of Maryland, College Park, MD (United States)

    2014-09-01

    Low temperature plasma (LTP) treatment of biological tissue is a promising path toward sterilization of bacteria due to its versatility and ability to operate under well-controlled and relatively mild conditions. The present collaborative research of an interdisciplinary team of investigators at University of Maryland, College Park (UMD), and University of California, Berkeley (UCB) focused on establishing our knowledge based with regard to low temperature plasma-induced chemical modifications in biomolecules that result in inactivation due to various plasma species, including ions, reactive radicals, and UV/VUV photons. The overall goals of the project were to identify and quantify the mechanisms by which low and atmospheric pressure plasma deactivates endotoxic biomolecules. Additionally, we wanted to understand the mechanism by which atmospheric pressure plasmas (APP) modify surfaces and how these modifications depend on the interaction of APP with the environment. Various low pressure plasma sources, a vacuum beam system and several atmospheric pressure plasma sources were used to accomplish this. In our work we elucidated for the first time the role of ions, VUV photons and radicals in biological deactivation of representative biomolecules, both in a UHV beam system and an inductively coupled, low pressure plasma system, and established the associated atomistic biomolecule changes. While we showed that both ions and VUV photons can be very efficient in deactivation of biomolecules, significant etching and/or deep modification (~200 nm) accompanied these biological effects. One of the most important findings in this work is the significant radical-induced deactivation and surface modification can occur with minimal etching. However, if radical fluxes and corresponding etch rates are relatively high, for example at atmospheric pressure, endotoxic biomolecule film inactivation may require near-complete removal of the film. These findings motivated further work at

  20. Practicing biology: Undergraduate laboratory research, persistence in science, and the impact of self-efficacy beliefs

    Science.gov (United States)

    Berkes, Elizabeth

    As undergraduate laboratory research internships become more popular and universities devote considerable resources towards promoting them, it is important to clarify what students specifically gain through involvement in these experiences and it is important to understand their impact on the science pipeline. By examining recent findings describing the primary benefits of undergraduate research participation, along with self-efficacy theory, this study aims to provide more explanatory power to the anecdotal and descriptive accounts regarding the relationship between undergraduate research experiences and interest in continuing in science. Furthermore, this study characterizes practices that foster students' confidence in doing scientific work with detailed description and analysis of the interactions of researchers in a laboratory. Phase 1 of the study, a survey of undergraduate biology majors (n=71) at a major research university, investigates the relationships among participation in biology laboratory research internships, biology laboratory self-efficacy strength, and interest in persisting in science. Phase 2 of the study, a two-year investigation of a university biology research laboratory, investigates how scientific communities of practice develop self-efficacy beliefs. The findings suggest that participation in lab internships results in increased interest in continuing in life science/biology graduate school and careers. They also suggest that a significant proportion of that interest is related to the students' biology laboratory self-efficacy. The findings of this study point to two primary ways that undergraduate research participation might work to raise self-efficacy strength. First, university research laboratory communities can provide students with a variety of resources that scaffold them into biology laboratory mastery experiences. Second, university research laboratory communities can provide students with coping and mastery Discourse models

  1. Activities of Project 'Cooperation and development with Latin America and Iberian in Biological Dosimetry of Iberian Group of Radiation Protection Societies

    International Nuclear Information System (INIS)

    In 1996 the GRIAPRA Group (Latin American and Iberian Group of Radiation Protection Societies) was established with the participation of Argentina, Brazil, Cuba, Mexico, Peru, Portugal and Spain. In 1998 began the biennial Collaborative Working Project 'Cooperation and Development with Latin America in Biological Dosimetry', partially supported by the Extremadura Government, Spain, initially involving five countries: Argentina, Cuba, Peru, Portugal and Spain. The general aim of the project is to create an Latin American and Iberian Biological Dosimetry Laboratories Coordinated Group in order to: give mutual cooperation and to other countries if required, in the case of radiological accident; contribute to enhance the technical capabilities of the participant laboratories; promote the installment of laboratories on this field in countries that does not have it yet through the training of human resources and providing the necessary equipment and, finally, perform jointly research activities in biological dosimetry. The activities designed in order to accomplish the project specific aims for the 1998-2000 period have been achieved. Description and results are presented. (author)

  2. Research Projects that use Citizen-Science Data with NGSS

    Science.gov (United States)

    Walker, C. E.

    2014-12-01

    We are exploring how to utilize the vast Globe at Night database for use in K-12, keeping in mind the guidelines set by the Next Generation Science Standards (NGSS). Areas we are focusing on include data mining, suitable research questions, data sets to compare with Globe at Night, and analysis tools, as well as how best to engage teachers and students in the research. Globe at Night, a citizen-science program on monitoring light pollution, has a database with the potential to connect with factors embedded in NGSS: students could construct explanations and design solutions to light pollution issues, engage in argument from evidence and obtain, evaluate and communicate information. Projects could be multidisciplinary in nature, connecting the effects of light pollution on human health, wildlife, energy consumption and astronomy. We welcome feedback to help determine the direction and emphasis for the next phase of Globe at Night. The presentation will include the nature of the research in the context of NGSS, building on frameworks being developed with the Cornell Ornithology Lab, the National Park Service (NPS) and Fieldscope. NPS staff have the means to make a contiguous map of light pollution across the U.S.. Fieldscope staff are developing the analysis tools online. And the Ornithology Lab has citizen-science data on various birds. The Globe at Night citizen-science campaign can be found at www.globeatnight.org.

  3. Biodiversity and biogeography of hydrothermal vent species in the western Pacific: a biological perspective of TAIGA project

    Science.gov (United States)

    Seo, M.; Watanabe, H.; Nakamura, M.; Sasaki, T.; Ogura, T.; Yahagi, T.; Takahashi, Y.; Ishibashi, J.; Kojima, S.

    2012-12-01

    Deep-sea hydrothermal vents are scientifically interesting environments where strong interactions of geology, chemistry, and biology can be observed. The hydrothermal vents are geologically controlled in association with magmatic activities while diversity of chemicals (such as hydrogen sulfide) contained in hydrothermal fluid is controlled by geochemical interaction between heated seawater and surrounding rocks. In addition to those geological and chemical characters of hydrothermal vents, high biomasses of chemosynthetic community have been known around many vents since the first discovery in the 1970s. To understand the unique system and diversity of biological communities associated with vents is highly valuable in geological, chemical, and biological sciences. As an activity of the research project "TAIGA (Trans-crustal Advection & In-situ bio-geochemical processes of Global sub-seafloor Aquifer)" (Representative: Tetsuro Urabe, Department of Earth & Planetary Science, the University of Tokyo), we analyzed population structures and connectivity as well as larval ecology of various hydrothermal vent species in the Okinawa Trough and the Mariana Trough in an attempt to estimate faunal transitional history associated with hydrothermal activities. The specimens analyzed in the present study were collected by R/V Yokosuka with manned submersible Shinkai6500 and R/V Natsushima with ROV Hyper-Dolphin during YK10-11 and NT11-20 cruises, respectively. In the Mariana Trough (YK10-11), benthic and planktonic faunas were investigated by multiple sampling and use of plankton samplers in three hydrothermal vents (Snail, Archaean, and Urashima-Pika fields). Faunal compositions were then compared as well as size compositions and genetic diversities of major vent species among local populations. In the Okinawa Trough (NT11-20), multiple quantitative sampling was made with simultaneous environmental measurements at more than two sites in five hydrothermal vents (Minami

  4. The role of evolutionary biology in research and control of liver flukes in Southeast Asia.

    Science.gov (United States)

    Echaubard, Pierre; Sripa, Banchob; Mallory, Frank F; Wilcox, Bruce A

    2016-09-01

    Stimulated largely by the availability of new technology, biomedical research at the molecular-level and chemical-based control approaches arguably dominate the field of infectious diseases. Along with this, the proximate view of disease etiology predominates to the exclusion of the ultimate, evolutionary biology-based, causation perspective. Yet, historically and up to today, research in evolutionary biology has provided much of the foundation for understanding the mechanisms underlying disease transmission dynamics, virulence, and the design of effective integrated control strategies. Here we review the state of knowledge regarding the biology of Asian liver Fluke-host relationship, parasitology, phylodynamics, drug-based interventions and liver Fluke-related cancer etiology from an evolutionary biology perspective. We consider how evolutionary principles, mechanisms and research methods could help refine our understanding of clinical disease associated with infection by Liver Flukes as well as their transmission dynamics. We identify a series of questions for an evolutionary biology research agenda for the liver Fluke that should contribute to an increased understanding of liver Fluke-associated diseases. Finally, we describe an integrative evolutionary medicine approach to liver Fluke prevention and control highlighting the need to better contextualize interventions within a broader human health and sustainable development framework. PMID:27197053

  5. The national research project MURST/CNR-ENEA on the protection of the human being and environment from electromagnetic pollution

    International Nuclear Information System (INIS)

    Electric, magnetic and electromagnetic fields interact with the human body and other biological systems through a number of physical mechanisms. People are continually exposed to electric and magnetic fields arising from a wide variety of sources that use electrical energy at various frequencies and levels. At the same time, a great deal of speculation and research has occurred concerning possible health risks arising from exposure to electric and magnetic fields and to take the appropriate steps. Especially in the latest years, Italy has been very careful in the electromagnetic pollution problem. The Italian Environment Ministry has enacted the decree 381/98 on safety in electromagnetic fields (exposure limits and quality targets) related to communication systems. The Italian Senate is discussing about a new framework law to reorganize all the subject. On the scientific level a new project of research, called Project 5%, on the protection of the human being and environment has been planned. This paper offers an overview on Project 5%

  6. The CARE project - Coordinated Accelerator Research in Europe

    CERN Multimedia

    2003-01-01

    A one-day presentation of the project will take place on Monday February 10th in the CERN Council Chamber. The meeting will start a 9am and is expected to end at 4:30pm. The meeting, which is open to the whole community, will present an initiative on accelerator R&D in Europe, supported by ECFA, with the aim to bid for European Union support through the Framework 6 scheme. This initiative is coordinated by a steering group (ESGARD - European Steering Group on Accelerator Research and Development), which has been set up to coordinate European efforts on accelerator R&D and the submission of such bids. The initial bids have to be submitted by April 15th. All those interested in accelerator R&D are welcome to attend.

  7. Development of a virtual research environment in ITBL project

    International Nuclear Information System (INIS)

    With the progress of computers and high-speed networks, it becomes possible to perform research work efficiently by combining computing, data and experimental resources which are widely distributed over multi-sites, or by sharing information among collaborators who belong to different organizations. An experimental application of Grid computing was executed in ITBL (information technology based laboratory) project promoted by six member institutes of MEXT (ministry of education, culture, sports, sciences and technology). Key technologies that are indispensable for construction of virtual organization were implemented onto ITBL Middle-ware and examined in the experiment from a view point of availability. It seems that successful result in the implementation and examination of those technologies such as security infrastructure, component programming and collaborative visualization in practical computer/network systems means significant progress in Science Grid in Japan

  8. Magma Energy Research Project, FY 1979 annual progress report

    Energy Technology Data Exchange (ETDEWEB)

    Colp, J.L.

    1979-12-01

    The objective of the Magma Energy Research Project is to define the scientific feasibility of extracting energy from magma bodies. Activities to accomplish the objective are divided into five tasks: resource location and identification; source tapping; magma characterization; materials compatibility; and energy extraction. The program activities of FY 1979 are summarized here according to the individual tasks. Major emphasis of the program in the last year was on field experimentation with the United States Geological Survey in geoscience and technological studies at the Kilauea Iki lava lake. Other major efforts included installation of the magma simulation facility and magma-metal compatibility studies. The Magma Energy Advisory Panel also met during this period. Efforts and results are summarized.

  9. National Space Biomedical Research Institute (NSBRI) JSC Summer Projects

    Science.gov (United States)

    Dowdy, Forrest Ryan

    2014-01-01

    This project optimized the calorie content in a breakfast meal replacement bar for the Advanced Food Technology group. Use of multivariable optimization yielded the highest weight savings possible while simultaneously matching NASA Human Standards nutritional guidelines. The scope of this research included the study of shelf-life indicators such as water activity, moisture content, and texture analysis. Key metrics indicate higher protein content, higher caloric density, and greater mass savings as a result of the reformulation process. The optimization performed for this study demonstrated wide application to other food bars in the Advanced Food Technology portfolio. Recommendations for future work include shelf life studies on bar hardening and overall acceptability data over increased time frames and temperature fluctuation scenarios.

  10. Pacific Lamprey Research and Restoration Project : Annual Report 2001.

    Energy Technology Data Exchange (ETDEWEB)

    Close, David A.

    2002-11-01

    Pacific lamprey (Lampetra tridentata) has significantly declined along the Oregon coast and in the Columbia River Basin (Downey et al. 1993; Close and Jackson 2001). Declines in adults can be partially attributed to hydroelectric dams, which have impeded passage of adult Pacific lamprey in the Columbia and Snake rivers, thus effecting larval recruitment in the basin. Adult pacific lamprey also declined in numbers in the Umatilla River, a tributary of the Columbia River. In addition to hydro power dams in the Columbia River, habitat alterations and chemical treatments have been involved in the collapse of Pacific lamprey populations in the Umatilla River. To initiate the restoration effort, CTUIR began developing a restoration plan in 1998. The goal of the lamprey research and restoration project is to restore natural production of Pacific lampreys in the Umatilla River to self-sustaining and harvestable level. This report is summarizing the studies and restoration efforts concluded in 2001.

  11. Development of a virtual research environment in ITBL project

    Energy Technology Data Exchange (ETDEWEB)

    Kenji, Higuchi; Takayuki, Otani; Yukihiro, Hasegawa; Yoshio, Suzuki; Nobuhiro, Yamagishi; Kazuyuki, Kimura; Tetsuo, Aoyagi; Norihiro, Nakajima; Masahiro, Fukuda [Japan Atomic Energy Research Institute (Japan); Toshiyuki, Imamura [University of Electro-Communications (Japan); Genki, Yagawa [Tokyo University (Japan)

    2003-07-01

    With the progress of computers and high-speed networks, it becomes possible to perform research work efficiently by combining computing, data and experimental resources which are widely distributed over multi-sites, or by sharing information among collaborators who belong to different organizations. An experimental application of Grid computing was executed in ITBL (information technology based laboratory) project promoted by six member institutes of MEXT (ministry of education, culture, sports, sciences and technology). Key technologies that are indispensable for construction of virtual organization were implemented onto ITBL Middle-ware and examined in the experiment from a view point of availability. It seems that successful result in the implementation and examination of those technologies such as security infrastructure, component programming and collaborative visualization in practical computer/network systems means significant progress in Science Grid in Japan.

  12. NTRCI Legacy Engine Research and Development Project Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith-Holbert, Connie [National Transportation Research Center, Inc., Knoxville, TN (United States); Petrolino, Joseph [National Transportation Research Center, Inc., Knoxville, TN (United States); Watkins, Bart [Power Source Technologies Inc., Corvallis, OR (United States); Irick, David [Power Source Technologies Inc., Corvallis, OR (United States)

    2011-12-31

    The Legacy engine is a completely new design, transitional diesel engine, replacing the reciprocating engine with a rotary engine. The Legacy engine offers significant advances over conventional internal combustion engines in 1) power to weight ratio; 2) multiple fuel acceptance; 3) fuel economy; and 4) environmental compliance. These advances are achieved through a combination of innovative design geometry, rotary motion, aspiration simplicity, and manufacturing/part simplicity. The key technical challenge to the Legacy engine's commercialization, and the focus of this project, was the development of a viable roton tip seal. The PST concept for the roton tip seal was developed into a manufacturable design. The design was evaluated using a custom designed and fabricated seal test fixture and further refined. This design was incorporated into the GEN2.5A prototype and tested for achievable compression pressure. The Decision Point at the end of Phase 1 of the project (described below) was to further optimize the existing tip seal design. Enhancements to the tip seal design were incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Compression pressures adequate for compression ignition of diesel fuel were achieved, although not consistently in all combustion volumes. The variation in compression pressures was characterized versus design features. As the roton tip seal performance was improved, results pointed toward inadequate performance of the housing side seals. Enhancement of the housing side seal system was accomplished using a custom designed side seal test fixture. The design enhancements developed with the test fixture were also incorporated into the GEN2.5B prototype and tested and evaluated using the iterative research strategy described below. Finally, to simplify the requirements for the roton tip seals and to enhance the introduction and combustion of fuel, a flush-mount fuel injector

  13. The Dark Snow Project: a hybrid research communication program

    Science.gov (United States)

    Box, J. E.; Sinclair, P.

    2015-12-01

    The Dark Snow Project, to crowd fund and communicate Greenland ice-climate interactions expedition research, was a baptism by fire climate communications venture. We did it without a guide book and ran on pure inspiration. Along the way, we acquired quite some of the communication skill set: marketing; social psychology; crowd funding; conventional media; video production; social media.The aim of this presentation is to inventory lessons learned, experience, and resolve recommendations how to do it better for those adventurous enough to do a crowd funded actvity. Key themes are amplifying basic research, engagement in citizen science, outreach, communication.Quickly, one begins thinking of success tactics, like launching news on a Monday instead of a Saturday or keeping the conversation going by telling the story from different and evolving perspectives. The experience taught that unconventional funding is harder won than conventional funding. Yet, because the support came from unconventional sources, the public, we began tapping a large resource in citizen science engagement. If having a compelling call to action such a campaign can be a significant source of sustain. What had also proven difficult was doing it with a small team when each of the following skills demands a larger group; running a media campaign; logistics; video recording and editing; social media promotion; conventional media engagement. The issue and brand awareness grows in a snowball effect encouraging us to run successive annual campaigns.Now in third year, the project can be more effective if upscaling from a single to a multi-cell organization.

  14. A Framework for Improving the Quality of Research in the Biological Sciences

    Science.gov (United States)

    Ellis, Lee M.; Davies, Erika W.; McFall-Ngai, Margaret; Fang, Ferric C.

    2016-01-01

    ABSTRACT The American Academy of Microbiology convened a colloquium to discuss problems in the biological sciences, with emphasis on identifying mechanisms to improve the quality of research. Participants from various disciplines made six recommendations: (i) design rigorous and comprehensive evaluation criteria to recognize and reward high-quality scientific research; (ii) require universal training in good scientific practices, appropriate statistical usage, and responsible research practices for scientists at all levels, with training content regularly updated and presented by qualified scientists; (iii) establish open data at the timing of publication as the standard operating procedure throughout the scientific enterprise; (iv) encourage scientific journals to publish negative data that meet methodologic standards of quality; (v) agree upon common criteria among scientific journals for retraction of published papers, to provide consistency and transparency; and (vi) strengthen research integrity oversight and training. These recommendations constitute an actionable framework that, in combination, could improve the quality of biological research. PMID:27578756

  15. A Framework for Improving the Quality of Research in the Biological Sciences.

    Science.gov (United States)

    Casadevall, Arturo; Ellis, Lee M; Davies, Erika W; McFall-Ngai, Margaret; Fang, Ferric C

    2016-01-01

    The American Academy of Microbiology convened a colloquium to discuss problems in the biological sciences, with emphasis on identifying mechanisms to improve the quality of research. Participants from various disciplines made six recommendations: (i) design rigorous and comprehensive evaluation criteria to recognize and reward high-quality scientific research; (ii) require universal training in good scientific practices, appropriate statistical usage, and responsible research practices for scientists at all levels, with training content regularly updated and presented by qualified scientists; (iii) establish open data at the timing of publication as the standard operating procedure throughout the scientific enterprise; (iv) encourage scientific journals to publish negative data that meet methodologic standards of quality; (v) agree upon common criteria among scientific journals for retraction of published papers, to provide consistency and transparency; and (vi) strengthen research integrity oversight and training. These recommendations constitute an actionable framework that, in combination, could improve the quality of biological research. PMID:27578756

  16. Bioterrorism and biological threats dominate federal health security research; other priorities get scant attention.

    Science.gov (United States)

    Shelton, Shoshana R; Connor, Kathryn; Uscher-Pines, Lori; Pillemer, Francesca Matthews; Mullikin, James M; Kellermann, Arthur L

    2012-12-01

    The federal government plays a critical role in achieving national health security by providing strategic guidance and funding research to help prevent, respond to, mitigate, and recover from disasters, epidemics, and acts of terrorism. In this article we describe the first-ever inventory of nonclassified national health security-related research funded by civilian agencies of the federal government. Our analysis revealed that the US government's portfolio of health security research is currently weighted toward bioterrorism and emerging biological threats, laboratory methods, and development of biological countermeasures. Eight of ten other priorities identified in the Department of Health and Human Services' National Health Security Strategy-such as developing and maintaining a national health security workforce or incorporating recovery into planning and response-receive scant attention. We offer recommendations to better align federal spending with health security research priorities, including the creation of an interagency working group charged with minimizing research redundancy and filling persistent gaps in knowledge.

  17. Critical infrastructure protection research results of the first critical infrastructure protection research project in Hungary

    CERN Document Server

    Padányi, József

    2016-01-01

    This book presents recent research in the recognition of vulnerabilities of national systems and assets which gained special attention for the Critical Infrastructures in the last two decades. The book concentrates on R&D activities in the relation of Critical Infrastructures focusing on enhancing the performance of services as well as the level of security. The objectives of the book are based on a project entitled "Critical Infrastructure Protection Researches" (TÁMOP-4.2.1.B-11/2/KMR-2011-0001) which concentrated on innovative UAV solutions, robotics, cybersecurity, surface engineering, and mechatrinics and technologies providing safe operations of essential assets. This report is summarizing the methodologies and efforts taken to fulfill the goals defined. The project has been performed by the consortium of the Óbuda University and the National University of Public Service.

  18. Breaking the Biological Barriers to Cellulosic Ethanol: A Joint Research Agenda

    Energy Technology Data Exchange (ETDEWEB)

    Houghton, John [Dept. of Energy (DOE), Washington DC (United States); Weatherwax, Sharlene [Dept. of Energy (DOE), Washington DC (United States); Ferrell, John [Dept. of Energy (DOE), Washington DC (United States)

    2006-06-07

    The Biomass to Biofuels Workshop, held December 7–9, 2005, was convened by the Department of Energy’s Office of Biological and Environmental Research in the Office of Science; and the Office of the Biomass Program in the Office of Energy Efficiency and Renewable Energy. The purpose was to define barriers and challenges to a rapid expansion of cellulosic-ethanol production and determine ways to speed solutions through concerted application of modern biology tools as part of a joint research agenda. Although the focus was ethanol, the science applies to additional fuels that include biodiesel and other bioproducts or coproducts having critical roles in any deployment scheme.

  19. A Case Study of Teaching Marketing Research Using Client-Sponsored Projects: Method, Challenges, and Benefits

    Science.gov (United States)

    Bove, Liliana L.; Davies, W. Martin

    2009-01-01

    This case study outlines the use of client-sponsored research projects in a quantitative postgraduate marketing research subject conducted in a 12-week semester in a research-intensive Australian university. The case study attempts to address the dearth of recent literature on client-sponsored research projects in the discipline of marketing.…

  20. Reshaping Literacy in a High Poverty Early Childhood Classroom: One Teacher's Action Research Project

    Science.gov (United States)

    Rose, Lynnette; Vaughn, Margaret; Taylor, Linda

    2015-01-01

    This research explores an action research project conducted by the first author focused on supporting her preschool students' literacy and language development. Using observations, interviews, artifacts, and assessment, this research documents the first author's process of conducting an action research project over the course of one year to…

  1. Reasons for resubmission of research projects to the research ethics committee of a University Hospital in São Paulo, Brazil

    OpenAIRE

    Mariana Bueno; Maria Meimei Brevidelli; Thaís Cocarelli; Gianni Mara Silva dos Santos; Maria Auxiliadora Ferraz; Décio Mion Jr

    2009-01-01

    INTRODUCTION: It is important to know the reasons for resubmitting research projects to the Research Ethics Committee in order to help researchers to prepare their research projects, informed consent forms and needed research documentation. OBJECTIVES: To verify the reasons for resubmitting projects that were previously rejected by the Ethics Committee. METHOD: This is a cross-sectional study that evaluated research projects involving human beings. Research projects were submitted in 2007 to ...

  2. Highly cited German research contributions to the fields of radiation oncology, biology, and physics. Focus on collaboration and diversity

    Energy Technology Data Exchange (ETDEWEB)

    Nieder, C. [Nordland Hospital, Bodoe (Norway). Dept. of Oncology and Palliative Medicine; Tromsoe Univ. (Norway). Inst. of Clinical Medicine

    2012-10-15

    Background and purpose: Tight budgets and increasing competition for research funding pose challenges for highly specialized medical disciplines such as radiation oncology. Therefore, a systematic review was performed of successfully completed research that had a high impact on clinical practice. These data might be helpful when preparing new projects. Methods: Different measures of impact, visibility, and quality of published research are available, each with its own pros and cons. For this study, the article citation rate was chosen (minimum 15 citations per year on average). Highly cited German contributions to the fields of radiation oncology, biology, and physics (published between 1990 and 2010) were identified from the Scopus database. Results: Between 1990 and 2010, 106 articles published in 44 scientific journals met the citation requirement. The median average of yearly citations was 21 (maximum 167, minimum 15). All articles with {>=} 40 citations per year were published between 2003 and 2009, consistent with the assumption that the citation rate gradually increases for up to 2 years after publication. Most citations per year were recorded for meta-analyses and randomized phase III trials, which typically were performed by collaborative groups. Conclusion: A large variety of clinical radiotherapy, biology, and physics topics achieved high numbers of citations. However, areas such as quality of life and side effects, palliative radiotherapy, and radiotherapy for nonmalignant disorders were underrepresented. Efforts to increase their visibility might be warranted. (orig.)

  3. Research and development project reports for FY 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-09-01

    The paper reported NEDO`s research and development project in fiscal 1995. As for the development of solar energy utilization technology, conducted were R and D of solar cells and development of the photovoltaic power generation. As to the solar heat utilization technology, R and D were carried out on the chemical energy conversion technology and high efficient solar heat space heating and cooling technology. About the geothermal energy utilization technology, developments were made of exploration techniques for fracture-type geothermal reservoirs and the binary cycle geothermal power generation technology. Concerning the coal energy utilization technology, conducted were R and D of coal liquefaction and coal gasification. Relating to the NEDOL process, a 150t/d pilot plant is under construction. As to environmental issues on coal utilization, made was a research on the basic technology of clean coal. In addition, technical developments on the following were done: efficient power generation using fuel cells, hydrogen, alcohol, biomass, wind power generation, etc. 73 figs., 56 tabs.

  4. THE CONSTRUCTION OF A RESEARCH PROJECT IN A COMPLEXITY PERSPECTIVE

    Directory of Open Access Journals (Sweden)

    Nize Maria Campos Pellanda

    2013-12-01

    Full Text Available This article proposes the term ontoepistemogênese to designate the process of complexification of a subject, which, when coupled with its environment, becomes integrated with repercussions in all dimensions of the human being. The process of ontoepistemogênese in an autopoietic perspective, forced us to think in terms of self-construction as inseparable from processes and overlapping continuous vital flow of being, both in relation to internal and external processes. In this sense, the process for handling research data in the Project GAIA seeks always to address autopoietic cognitive/affective operations in each member of the group. Thus, humans build their inventive process of ontoepistemogênese in response to external disturbances and through a power, which is a result of the connections and belonging to the networks. To carry out such a task we searched mainly to the guidelines that are setting the paradigm of complexity, as has been expressed mainly by Edgar Morin (Morin, 1991 and Clara da Costa Oliveira, (1999, 2004, 2005. In addition, among other researchers in the same field, we used Humberto Maturana and Francisco Varela to construct a set of operative elements, which led us to the understanding of life, by bringing the principle of self-organization and, more specifically, the concept of autopoiesis to understand this dense web of relations that constitute the living system.

  5. TR32DB - Management of Research Data in a Collaborative, Interdisciplinary Research Project

    Science.gov (United States)

    Curdt, Constanze; Hoffmeister, Dirk; Waldhoff, Guido; Lang, Ulrich; Bareth, Georg

    2015-04-01

    The management of research data in a well-structured and documented manner is essential in the context of collaborative, interdisciplinary research environments (e.g. across various institutions). Consequently, set-up and use of a research data management (RDM) system like a data repository or project database is necessary. These systems should accompany and support scientists during the entire research life cycle (e.g. data collection, documentation, storage, archiving, sharing, publishing) and operate cross-disciplinary in interdisciplinary research projects. Challenges and problems of RDM are well-know. Consequently, the set-up of a user-friendly, well-documented, sustainable RDM system is essential, as well as user support and further assistance. In the framework of the Transregio Collaborative Research Centre 32 'Patterns in Soil-Vegetation-Atmosphere Systems: Monitoring, Modelling, and Data Assimilation' (CRC/TR32), funded by the German Research Foundation (DFG), a RDM system was self-designed and implemented. The CRC/TR32 project database (TR32DB, www.tr32db.de) is operating online since early 2008. The TR32DB handles all data, which are created by the involved project participants from several institutions (e.g. Universities of Cologne, Bonn, Aachen, and the Research Centre Jülich) and research fields (e.g. soil and plant sciences, hydrology, geography, geophysics, meteorology, remote sensing). Very heterogeneous research data are considered, which are resulting from field measurement campaigns, meteorological monitoring, remote sensing, laboratory studies and modelling approaches. Furthermore, outcomes like publications, conference contributions, PhD reports and corresponding images are regarded. The TR32DB project database is set-up in cooperation with the Regional Computing Centre of the University of Cologne (RRZK) and also located in this hardware environment. The TR32DB system architecture is composed of three main components: (i) a file-based data

  6. Managing Risk and Uncertainty in Large-Scale University Research Projects

    Science.gov (United States)

    Moore, Sharlissa; Shangraw, R. F., Jr.

    2011-01-01

    Both publicly and privately funded research projects managed by universities are growing in size and scope. Complex, large-scale projects (over $50 million) pose new management challenges and risks for universities. This paper explores the relationship between project success and a variety of factors in large-scale university projects. First, we…

  7. It's more than stamp collecting: how genome sequencing can unify biological research.

    Science.gov (United States)

    Richards, Stephen

    2015-07-01

    The availability of reference genome sequences, especially the human reference, has revolutionized the study of biology. However, while the genomes of some species have been fully sequenced, a wide range of biological problems still cannot be effectively studied for lack of genome sequence information. Here, I identify neglected areas of biology and describe how both targeted species sequencing and more broad taxonomic surveys of the tree of life can address important biological questions. I enumerate the significant benefits that would accrue from sequencing a broader range of taxa, as well as discuss the technical advances in sequencing and assembly methods that would allow for wide-ranging application of whole-genome analysis. Finally, I suggest that in addition to 'big science' survey initiatives to sequence the tree of life, a modified infrastructure-funding paradigm would better support reference genome sequence generation for research communities most in need.

  8. Using Independent Research Projects to Foster Learning in the Comparative Vertebrate Anatomy Laboratory

    Science.gov (United States)

    Ghedotti, Michael J.; Fielitz, Christopher; Leonard, Daniel J.

    2005-01-01

    This paper presents a teaching methodology involving an independent research project component for use in undergraduate Comparative Vertebrate Anatomy laboratory courses. The proposed project introduces cooperative, active learning in a research context to comparative vertebrate anatomy. This project involves pairs or groups of three students…

  9. Project for Minorities and Women in Research: Status Report, 1979 and Proposed Activities, 1980.

    Science.gov (United States)

    Escobedo, Theresa Herrera; Acevedo, Baltazar

    An experimental project at the University of Texas at Austin, which was designed to increase the participation of minorities and women in educational research and related work, is described. The project brings together individuals who are at the post-doctoral and pre-doctoral level to cooperatively work on research questions. The project model…

  10. Research-Informed Curriculum Design for a Master's-Level Program in Project Management

    Science.gov (United States)

    Bentley, Yongmei; Richardson, Diane; Duan, Yanqing; Philpott, Elly; Ong, Vincent; Owen, David

    2013-01-01

    This article reports on the application of Research-Informed Curriculum Design (RICD) for the development and implementation of an MSc Program in Project Management. The research focused on contemporary issues in project management and provided an analysis of project management approaches, tools, and techniques currently used in organizations.…

  11. Risk management and post project evaluation processes for research and development projects

    OpenAIRE

    Altuğ, Sema Nur; Altug, Sema Nur

    2002-01-01

    Project risk management has become a popular subject in the last decade, in parallel with the developments in the field of project management to adopt to the uncertain and changing environment. Risk management is the systematic process of identifying, analyzing, andresponding to project risk. Successful project risk management will greatly improve theprobability of project success. It is necessary to learn from risk management activities, for obtaining improvements in the project management p...

  12. The Research of Project Management Tools and Techniques

    Institute of Scientific and Technical Information of China (English)

    XuDishi

    2005-01-01

    Effective project management on today's projects, where the emphasis is often on the rapid completion of the project, is not something that is learned entirely by reading a book or a report. But having the right training and the right tools makes a big difference. To be sure, even where project management is practiced professionally, the theories or the methodologies behind it are often misunderstood. As a role of management consultant, my report focus on the methods and their relationship project management use such as Earned Value Methodology, Scope Change Control, WBS (work breakdown structure) and Data Capture to plan, monitor and ultimately control projects. Thus, this report will contribute to a better understanding of how to utilize project management methods to plan and control projects so that they can be completed with constrain of time and cost. In addition, some companies in IT field for example can use computer software to manage project more effectively and efficiently.

  13. Small angle neutron scattering. Report of a coordinated research project 2000-2003

    International Nuclear Information System (INIS)

    Small angle neutron scattering (SANS) is a powerful technique for studying macro structures like polymers, precipitates in metallurgical specimens, biological molecules, micelles and magnetic systems like ferrofluids. Neutron scattering has an advantage over X ray scattering (XSAXS) due to selective absorption and scattering cross section of neutrons across the periodic table. It is possible to develop and use a SANS instrument even with a medium flux reactor. The present CRP was aimed at the development of components like collimators, monochromators, position sensitive detectors (PSD) etc. for improving the throughput of the instrument and foster the effective utilization of research reactors, as well as to provide a link between developing and developed facilities. The CRP was launched with the first research coordination meeting (RCM) in 2000 to refine the project proposals and define the action plans and partnerships. There were eight research contracts and four research agreements. Good partnerships were established between various participants with collaborations among participants from various countries including those from developing and developed countries. The progress of the individual projects and team work under the CRP was evaluated and discussed during the second RCM and the action plan for the final phase was formulated. The results of the work done under the CRP were then reviewed in the final RCM held in Vienna, December 2003. This publication presents the results of the work carried out by the participants under the CRP at their respective institutions. The information will be useful for the users and operators of research reactors in developing an instrument and building collaborations for capacity building. The development of collimators, detector assemblies, utilization of the SANS for microstructural characterization of advanced materials , development and design of a ultra small angle neutron scattering (USANS) and proposals for a new SANS

  14. 77 FR 37022 - Disability and Rehabilitation Research Projects and Centers Program; Rehabilitation Engineering...

    Science.gov (United States)

    2012-06-20

    ... Disability and Rehabilitation Research Projects and Centers Program; Rehabilitation Engineering Research... and Centers Program--Rehabilitation Engineering Research Centers (RERC). SUMMARY: The Assistant... populations; (3) determine ] the best strategies and programs to improve rehabilitation outcomes...

  15. Predicting Function of Biological Macromolecules: A Summary of LDRD Activities: Project 10746

    Energy Technology Data Exchange (ETDEWEB)

    FRINK, LAURA J. D.; REMPE, SUSAN L.; MEANS, SHAWN A.; STEVENS, MARK J.; CROZIER, PAUL S.; MARTIN, MARCUS G.; SEARS, MARK P.; HJALMARSON, HAROLD P.

    2002-11-01

    This LDRD project has involved the development and application of Sandia's massively parallel materials modeling software to several significant biophysical systems. They have been successful in applying the molecular dynamics code LAMMPS to modeling DNA, unstructured proteins, and lipid membranes. They have developed and applied a coupled transport-molecular theory code (Tramonto) to study ion channel proteins with gramicidin A as a prototype. they have used the Towhee configurational bias Monte-Carlo code to perform rigorous tests of biological force fields. they have also applied the MP-Sala reacting-diffusion code to model cellular systems. Electroporation of cell membranes has also been studied, and detailed quantum mechanical studies of ion solvation have been performed. In addition, new molecular theory algorithms have been developed (in FasTram) that may ultimately make protein solvation calculations feasible on workstations. Finally, they have begun implementation of a combined molecular theory and configurational bias Monte-Carlo code. They note that this LDRD has provided a basis for several new internal (e.g. several new LDRD) and external (e.g. 4 NIH proposals and a DOE/Genomes to Life) proposals.

  16. A review of projection radiography of plasma and biological objects in X-Pinch radiation

    Science.gov (United States)

    Shelkovenko, T. A.; Pikuz, S. A.; Hammer, D. A.

    2016-03-01

    A review of studies on the X-pinch as a radiation source for X-ray projection shadow radiography (XPSR) and X-ray absorption spectroscopy (XAS) is presented. The ultimate capabilities of the techniques and ways of their achievement are considered. XPSR has been successfully used to study high-energy-density plasma objects, in particular, exploding wires and wire arrays. Using XPSR, the internal structure and dynamics of a wire explosion and wire array implosion have been investigated for the first time, which has made it possible to develop an adequate consistent theory of the processes occurring in the wire loads of generators with currents from several units of kiloamperes to a few tens of megamperes. The use of XAS for diagnostics of wire loads has allowed one for the first time to measure the parameters of matter in the wire core and plasma corona of the load. X-ray images of various biological objects have obtained, including those with the use of the phase contrast method. This review is a logical continuation of the review "X-Pinch" [Plasma Phys. Rep. 41, 319, 493 (2015)], in which the X-pinch as a physical object was considered.

  17. Fundamentals of space biology research on cells, animals, and plants in space

    CERN Document Server

    DeLorenzo, Michael L; Slenzka, K

    2006-01-01

    This book is intended as an overview at an undergraduate or early university level and describes the effects of spaceflight at cellular and organism levels. Past, current, and future research on the effects of gravity - or its absence - and ionizing radiation on the evolution, development, and function of living organisms is presented in layman's terms by researchers who have been active in this field. The purpose is to enlighten science and non-science readers to the benefits of space biology research for conducting basic and applied research to support human exploration of space and to take

  18. BIO2010 and beyond: What undergraduate physics does the next generation of molecular biology researchers need?

    Science.gov (United States)

    Howard, Jonathon

    2004-03-01

    What fundamental skills in mathematics, chemistry, physics, computer science and engineering are required at the undergraduate level to prepare the next generation of biology majors who will become research scientists? To address this question, Bruce Alberts, President of the National Academy of Sciences, established BIO2010, a committee of the National Research Council (USA), chaired by Lubert Stryer. The report of the committee was published in 2003 as BIO2010: Transforming Undergraduate Education for Future Research Biologists (National Academies Press, Washington DC, www.national-academies.com). I will summarize the recommendations of the Physics and Engineering Panel that was chaired by John Hopfield and give my own views of what physics is essential for researchers in cell and molecular biology.

  19. Decommissioning of the ASTRA research reactor: Dismantling of the biological shield

    Directory of Open Access Journals (Sweden)

    Meyer Franz

    2006-01-01

    Full Text Available The paper describes the dismantling of the inactive and activated areas of the biological shield of the ASTRA research reactor at the Austrian Research Center in Seibersdorf. The calculation of the parameters determining the activated areas at the shield (reference nuclide, nuclide vector in the barite concrete and horizontal and vertical reduction behaviors of activity concentration and the activation profiles within the biological shield for unrestricted release, release restricted to permanent deposit and radioactive waste are presented. Considerations of located activation anomalies in the shield, e.g. in the vicinities of the beam-tubes, were made according to the reactor's operational history. Finally, an overview of the materials removed from the biological shield is given.

  20. Artificial Cell Research as a Field that Connects Chemical, Biological and Philosophical Questions.

    Science.gov (United States)

    Deplazes-Zemp, Anna

    2016-01-01

    This review article discusses the interdisciplinary nature and implications of artificial cell research. It starts from two historical theories: Gánti's chemoton model and the autopoiesis theory by Maturana and Varela. They both explain the transition from chemical molecules to biological cells. These models exemplify two different ways in which disciplines of chemistry, biology and philosophy can profit from each other. In the chemoton model, conclusions from one disciplinary approach are relevant for the other disciplines. In contrast, the autopoiesis model itself (rather than its conclusions) is transferred from one discipline to the other. The article closes by underpinning the relevance of artificial cell research for philosophy with reference to the on-going philosophical debates on emergence, biological functions and biocentrism. PMID:27363375

  1. Biologically plausible and evidence-based risk intervals in immunization safety research.

    Science.gov (United States)

    Rowhani-Rahbar, Ali; Klein, Nicola P; Dekker, Cornelia L; Edwards, Kathryn M; Marchant, Colin D; Vellozzi, Claudia; Fireman, Bruce; Sejvar, James J; Halsey, Neal A; Baxter, Roger

    2012-12-17

    In immunization safety research, individuals are considered at risk for the development of certain adverse events following immunization (AEFI) within a specific period of time referred to as the risk interval. These intervals should ideally be determined based on biologic plausibility considering features of the AEFI, presumed or known pathologic mechanism, and the vaccine. Misspecification of the length and timing of these intervals may result in introducing bias in epidemiologic and clinical studies of immunization safety. To date, little work has been done to formally assess and determine biologically plausible and evidence-based risk intervals in immunization safety research. In this report, we present a systematic process to define biologically plausible and evidence-based risk interval estimates for two specific AEFIs, febrile seizures and acute disseminated encephalomyelitis. In addition, we review methodologic issues related to the determination of risk intervals for consideration in future studies of immunization safety.

  2. Decommissioning of the ASTRA research reactor - dismantling of the biological shield

    International Nuclear Information System (INIS)

    The paper describes the dismantling of the inactive and activated areas of the biological shield of the ASTRA research reactor at the Austrian Research Center in Seibersdorf. The calculation of the parameters determining the activated areas at the shield (reference nuclide, nuclide vector in the barite concrete and horizontal and vertical reduction behaviors of activity concentration) and the activation profiles within the biological shield for unrestricted release, release restricted to permanent deposit and radioactive waste are presented. Considerations of located activation anomalies in the shield, e. g. in the vicinities of the beam-tubes, were made according to the reactor's operational history. Finally, an overview of the materials removed from the biological shield is given. (author)

  3. Data and knowledge management in cross-Omics research projects.

    Science.gov (United States)

    Wiesinger, Martin; Haiduk, Martin; Behr, Marco; de Abreu Madeira, Henrique Lopes; Glöckler, Gernot; Perco, Paul; Lukas, Arno

    2011-01-01

    Cross-Omics studies aimed at characterizing a specific phenotype on multiple levels are entering the -scientific literature, and merging e.g. transcriptomics and proteomics data clearly promises to improve Omics data interpretation. Also for Systems Biology the integration of multi-level Omics profiles (also across species) is considered as central element. Due to the complexity of each specific Omics technique, specialization of experimental and bioinformatics research groups have become necessary, in turn demanding collaborative efforts for effectively implementing cross-Omics. This setting imposes specific emphasis on data sharing platforms for Omics data integration and cross-Omics data analysis and interpretation. Here we describe a software concept and methodology fostering Omics data sharing in a distributed team setting which next to the data management component also provides hypothesis generation via inference, semantic search, and community functions. Investigators are supported in data workflow management and interpretation, supporting the transition from a collection of heterogeneous Omics profiles into an integrated body of knowledge. PMID:21370080

  4. The Danish energy crop research and development project - main conclusions

    International Nuclear Information System (INIS)

    Production of energy crops in Denmark is more or less non-existent in Denmark at the time being. However, the need for biomass on the other side of year 2005 exceeds the existing biomass resources and a substantial amount of energy crops will be necessary in order to fulfil the goals in Energy 21. The targeted share of the use of renewable energy sources by year 2030 is approximately 30%. Energy crops are seen as the most important new resource in order to create a balanced input mix of renewable in the energy system. The energy crops are mainly seen as fuel in small and medium sized CHP plants and in the big power plants. The Danish energy crop project consists of three main parts: a demonstration part, a research and development part, and an overall assessment part. Based on the results from the project the following overall conclusions can be made: Seen from a strictly market and production economic point of view energy crops will not be competitive in a foreseeable future, neither as a production for farmers nor as a fuel at the utility companies; The costs per GJ of energy crops are still higher than a GJ of straw; The cost difference between annual and perennial energy crops are slightly in favour of perennials, however the conditions on the individual farms should govern the choice between annual and perennial energy crops; Energy crops must be seen as part of an overall environmental scheme covering both agriculture and the energy sector; Given the right production scheme energy crops can be grown on environmental sensitive areas and on most ground water protection areas; Adding the potential sustainability benefits like reduced nutrient leakage and reduced CO2 emissions energy crops seem to be a sensible and sustainable solution; Due to different handling, storage and fuel characteristics an all year delivery scheme of energy crops should include a mix of different energy crops to keep overall cost down. (BA)

  5. RESEARCH OF QUALITY, SAFETY AND CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES OF FOOD RED BEET

    OpenAIRE

    Gorash E. Y.; Victorova E. P.; Kupin G. A.; Aleshin V. N.; Lisovoy V. V.

    2015-01-01

    The article presents results of research of quality, safety and content of biologically active substances of food red beet roots of Bordo 237 variety, grown in the Krasnodar region in 2014. On the basis of the research carried out it was established, that there are carbohydrates, proteins, organic acids and mineral substances in the food red beet roots of Bordo 237 variety. Food red beet roots are a source of dietary fibers (pectin, protopectin, hemicelluloses and cellulose), possessing antit...

  6. Interdisciplinary Training in Mathematical Biology through Team-Based Undergraduate Research and Courses

    Science.gov (United States)

    Miller, Jason E.; Walston, Timothy

    2010-01-01

    Inspired by "BIO2010" and leveraging institutional and external funding, Truman State University built an undergraduate program in mathematical biology with high-quality, faculty-mentored interdisciplinary research experiences at its core. These experiences taught faculty and students to bridge the epistemological gap between the mathematical and…

  7. The challenges for molecular nutrition research 4: the "nutritional systems biology level"

    NARCIS (Netherlands)

    Ommen, B. van; Cavallieri, D.; Roche, H.M.; Klein, U.I.; Daniel, H.

    2008-01-01

    Nutritional systems biology may be defined as the ultimate goal of molecular nutrition research, where all relevant aspects of regulation of metabolism in health and disease states at all levels of its complexity are taken into account to describe the molecular physiology of nutritional processes. T

  8. Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology

    OpenAIRE

    Peel, Andrew D

    2009-01-01

    A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased, 'forward genetics' approach to the study of genetic mechanisms operating in Tribolium. See research article http://biomedcentral.com/1741-7007/7/73

  9. Computer Literacy for Life Sciences: Helping the Digital-Era Biology Undergraduates Face Today's Research

    Science.gov (United States)

    Smolinski, Tomasz G.

    2010-01-01

    Computer literacy plays a critical role in today's life sciences research. Without the ability to use computers to efficiently manipulate and analyze large amounts of data resulting from biological experiments and simulations, many of the pressing questions in the life sciences could not be answered. Today's undergraduates, despite the ubiquity of…

  10. 76 FR 59407 - Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and...

    Science.gov (United States)

    2011-09-26

    ... Scientific and Medical Literature and Information on Non-Standardized Allergenic Extracts in the Diagnosis... scientific and medical literature and information concerning the use of non-standardized allergenic extracts... ``Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and...

  11. Building Consensus in Science: Resources for Intertextual Dialog in Biology Research Articles

    Science.gov (United States)

    Martinez, Iliana A.

    2008-01-01

    This paper reports on the way article writers bring prior texts into biology research articles. It studies the functional moves in which citations occur and their formal features, providing a better understanding of the linguistic resources that are used to construct intertextuality in science. The results show the functions of citations were…

  12. Decision making in inter‐corporate projects : A qualitative and quantitative study of project workers in automobile research and pre‐ development projects in Japan and Germany

    OpenAIRE

    Markkula, Petter

    2009-01-01

    This thesis is dealing with the integration of Japanese and German project workers in automobile inter‐corporate research/pre‐development projects. The focus is on better understanding the respective decision making process. As cultural differences play a big role in the way that people behave an extra focus was put on investigating this. The methods chosen for this study were quantitative research in the form of a questionnaire and qualitative research in the form of an interview series. For...

  13. Mode 3 Project-Based O-Level: Part II Biology

    Science.gov (United States)

    Greatorex, D.; Lock, R.

    1978-01-01

    Presents a British biology course for the O-level which aims to promote the understanding of broad biological principles through an environmental approach. Results of proper assessment and overall examination performance are also revealed. (HM)

  14. Regulatory research and support program for 1988/89 - project descriptions

    International Nuclear Information System (INIS)

    Information Bulletin, 1988. Project descriptions for the Regulatory Research and Support Program. This Information Bulletin contains a list of the projects with a brief description of each, and additional supporting information

  15. How can we improve problem-solving in undergraduate biology? Applying lessons from 30 years of physics education research

    CERN Document Server

    Hoskinson, Anne-Marie; Knight, Jennifer K

    2012-01-01

    Modern biological problems are complex. If students are to successfully grapple with such problems as scientists and citizens, they need to have practiced solving authentic, complex problems during their undergraduate years. Physics education researchers have investigated student problem-solving for the last three decades. Although the surface features and content of biology problems differ from physics problems, teachers of both sciences want students to learn to explain patterns and processes in the natural world and to make predictions about system behaviors. After surveying literature on problem-solving in physics and biology, we propose how biology education researchers could apply research-supported pedagogical techniques from physics to enhance biology students' problem-solving. First, we characterize the problems that biology students are typically asked to solve. We then describe the development of research-validated physics problem-solving curricula. Finally, we propose how biology scholars can appl...

  16. On Power Relation in the Design of Language Research Project and the Analysis of Data

    Science.gov (United States)

    Zhang, Wei

    2009-01-01

    How to deal with the relationship between the researcher and the "researched" is a crucial thing in design of a language research project and the analysis of data. The paper mainly focuses the influence of power relations between the researcher and the "researched" people. To do social research "on, for and with" the…

  17. Reports of reactor safety research projects sponsored by the Federal Ministry for Research and Technology (BMFT)

    International Nuclear Information System (INIS)

    Each progress report represents a compilation of individual reports about objectives, the work performed, the results, the next steps of the work etc. the individual reports are prepared in a standard form by the contractors themselves as a documentation of their progress in work and published by he FB (Research Coordination Department), Forschungsbetreuung at the GRS, within the framework of general information of progress in reactor safety research. The individual reports are classified according to the research program on the safety of LWRS 1977-1980 of the BMFT. Another table of contents uses the same classification system as applied in the nuclear safety index of the CEC (Commission of the European Communities) and the OECD (Organization for Economic Cooperation and Development). The reports are arranged in the sequence of their project numbers. (orig.)

  18. Research and Display Attributes of Social Science Fair Projects.

    Science.gov (United States)

    Loyless, Bonnie W.

    This study was designed to answer the following questions relative to social science fair projects: (1) To what extent were instructional media techniques utilized in the project display? (2) To what extent did teachers assist students with topic selection for the projects? (3) To what extent were the teachers and media specialists involved with…

  19. Introduction of International Fusion Energy Research Centre (IFERC) project

    International Nuclear Information System (INIS)

    A mission of the IFERC project is to accelerate the development of thermonuclear demo reactor by joining and contributing to the ITER project. It consists of three subprojects, the design of thermonuclear demo reactor, the computer simulation study on thermonuclear fusion and the remote experiment for ITER. In the present paper, present status, organization and future prospect of the project are described. (author)

  20. "On the Job" Learning: A Bioinformatics Course Incorporating Undergraduates in Actual Research Projects and Manuscript Submissions

    Science.gov (United States)

    Smith, Jason T.; Harris, Justine C.; Lopez, Oscar J.; Valverde, Laura; Borchert, Glen M.

    2015-01-01

    The sequencing of whole genomes and the analysis of genetic information continues to fundamentally change biological and medical research. Unfortunately, the people best suited to interpret this data (biologically trained researchers) are commonly discouraged by their own perceived computational limitations. To address this, we developed a course…