WorldWideScience

Sample records for biologics license application

  1. 9 CFR 102.4 - U.S. Veterinary Biologics Establishment License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biologics... LICENSES FOR BIOLOGICAL PRODUCTS § 102.4 U.S. Veterinary Biologics Establishment License. (a) Before a U.S. Veterinary Biologics Establishment License will be issued by the Administrator for any establishment, an...

  2. 14 CFR 431.73 - Continuing accuracy of license application; application for modification of license.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Continuing accuracy of license application; application for modification of license. 431.73 Section 431.73 Aeronautics and Space COMMERCIAL SPACE... Conditions § 431.73 Continuing accuracy of license application; application for modification of license. (a...

  3. 9 CFR 102.5 - U.S. Veterinary Biological Product License.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false U.S. Veterinary Biological Product... BIOLOGICAL PRODUCTS § 102.5 U.S. Veterinary Biological Product License. (a) Authorization to produce each biological product shall be specified on a U.S. Veterinary Biological Product License, issued by the...

  4. 21 CFR 310.4 - Biologics; products subject to license control.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Biologics; products subject to license control... to license control. (a) If a drug has an approved license under section 351 of the Public Health.... (b) To obtain marketing approval for radioactive biological products for human use, as defined in...

  5. IRIS pre-application licensing

    International Nuclear Information System (INIS)

    Carelli, Mario D.; Kling, Charles L.; Ritterbusch, Stanley E.

    2003-01-01

    This paper presents the approach to pre-application licensing by the International Reactor Innovative and Secure (IRIS), and advanced, integral reactor design with a thermal power of 1000 MW. The rationale for the pre-application licensing is discussed. Since IRIS technology is based on proven LWR experience, the project will rely on AP600/AP1000 precedent and will focus during the pre-application on long lead and novel items. A discussion of the evolution of the project to significantly reduce licensing issues is provided, followed by a summary of the IRIS safety-by-design which provides a formidable first step in the Defense in Depth approach. The effects of the safety-by-design, as well as of passive systems, on the IRIS safety will be investigated in a proposed testing program that will be reviewed by NRC during the pre-application. Documentation to be provided to NRC is discussed. Early design analyses indicate that the benefits of the IRIS safety-by-design approach are so significant that the basic premise of current emergency planning regulations (i.e., likelihood of core damage) will be reduced to the extent that special emergency response planning beyond the exclusion area boundary may not be needed. How this very significant outcome can be effected through a highly risk-informed licensing is discussed. (author)

  6. 21 CFR 515.10 - Medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Medicated feed mill license applications. 515.10... (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.10 Medicated feed mill license applications. (a) Medicated feed mill license applications (Forms FDA 3448) may...

  7. Product Licenses Database Application

    CERN Document Server

    Tonkovikj, Petar

    2016-01-01

    The goal of this project is to organize and centralize the data about software tools available to CERN employees, as well as provide a system that would simplify the license management process by providing information about the available licenses and their expiry dates. The project development process is consisted of two steps: modeling the products (software tools), product licenses, legal agreements and other data related to these entities in a relational database and developing the front-end user interface so that the user can interact with the database. The result is an ASP.NET MVC web application with interactive views for displaying and managing the data in the underlying database.

  8. 75 FR 72824 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-26

    ... & OFF License. Everglory Logistics, Inc. (NVO & OFF), 440 McClellan Highway, 105F2, East Boston, MA..., Application Type: New NVO & OFF License. Hawaii Intermodal Tank Transport, LLC (NVO & OFF), 2350 S. Dock... Tran, Manager, Application Type: New NVO & OFF License. ITL USA Inc. dba International Transport...

  9. Review process for license renewal applications

    International Nuclear Information System (INIS)

    Craig, John W.; Kuo, P.T.

    1991-01-01

    In preparation for license renewal reviews, the Nuclear Regulatory Commission has recently published for public review and comment a proposed rule for license renewal and a draft Standard Review Plan as well as a draft Regulatory Guide relating to the implementation of the proposed rule. In support of future license renewal applications, the nuclear industry has also submitted 11 industry reports for NRC review and approval. This paper briefly describe how these parallel regulatory and industry activities will be factored into the NRC review process for license renewal. (author)

  10. 25 CFR 141.9 - Application for license renewal.

    Science.gov (United States)

    2010-04-01

    ... Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES BUSINESS PRACTICES ON... the applicant has made as a reservation business owner and the applicant's present fitness to reside... pending consideration of application for license renewal. (c) Prior to expiration of the existing license...

  11. Personality traits of Turkish handgun license applicants.

    Science.gov (United States)

    Selek, Salih; Can, Serdar S; Yabanoglu, Ihsan

    2012-10-01

    Several theories have sought to explain the motivations for handgun possession and the relationship with personality. Perception of handguns also has cultural variations. The aim of the study is to evaluate handgun license applicants' personality profiles. 109 handgun license applicants were included in the study. Temperament and Character Inventory (TCI) scores of the applicants were recorded. Scores were compared with Turkish and American normative data for the Inventory. The study group had significantly lower subscores on novelty seeking, harm avoidance, and higher subscores on reward dependence and persistence compared to Turkish norms and significantly lower subscores on novelty seeking, reward dependence, and self-directedness compared to American norms. Results indicate that Turkish handgun license applicants' personality features are more similar to American norms.

  12. 75 FR 46938 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-04

    ... Logistics LLC (NVO), 120 S. Woodland Blvd., 216, DeLand, FL 32720, Officers: Dietmar Lutte, Manager Member, (Qualifying Individual), Susan Lutte, Member, Application Type: New NVO License. Bridgeline Logistics..., (Qualifying Individual), Application Type: New OFF License. [[Page 46939

  13. 77 FR 20398 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-04-04

    ...), Svi Soudai, Manager, Application Type: New OFF License. Armada USA, LLC dba Armada Logistics (NVO... Logistics (NVO & OFF), 435 Division Street, Elizabeth, NJ 07076, Officer: Carlos E. Feliu, President.../Treasurer, (Qualifying Individual), Application Type: New NVO License. HYC Logistics, Inc. (NVO & OFF), 2600...

  14. 47 CFR 80.53 - Application for a portable ship station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a portable ship station license... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Applications and Licenses § 80.53 Application for a portable ship station license. The Commission may grant a license permitting operation of a...

  15. 76 FR 44330 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-25

    .... Nguyen, Secretary/CFO, Application Type: New NVO & OFF License. Atlas Logistics LLC (NVO & OFF), 2801 NW...), Application Type: New NVO & OFF License. Bulk Cargo Services & Logistics Inc. (OFF), 15400 N.E. 103rd Drive..., Member/Chief Executive Manager, (Qualifying Individual), Stina Storr, Member/ Managing Member...

  16. 77 FR 24712 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-04-25

    ... Global Logistics LLC (OFF), 9816 Whithorn Drive, Suite B, Houston, TX 77095, Officer: Herbert R. Hogg, Operating Manager (Qualifying Individual), Application Type: New OFF License. Toyo Logistics America, Inc... Individual), Application Type: New NVO License. Choiceone Logistics, Inc. (NVO & OFF), 10025 NW 116th Way, 17...

  17. 75 FR 61757 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-10-06

    ...), Jinho Um, CFO. Application Type: New NVO & OFF License. Junction Int'l Logistics, Inc. (NVO), 17870 Castleton Street, Suite 107, City of Industry, CA 91748. Officers: Charles Kuo, Secretary (Qualifying.... Application Type: New NVO & OFF License. Red Arrow Consulting, Inc. dba Red Arrow Logistics (OFF), 14925 SE...

  18. 78 FR 6325 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-01-30

    .... Application Type: New NVO & OFF License. Naca Logistics (USA), Inc. dba Brennan International Transport, dba...). Application Type: New NVO & OFF License. Miami Freight & Logistics Services, Inc. (NVO & OFF), 3630 NW 76th... World Shipping, dba OWS, dba Ocean Express, dba Oceanexpress Vanguard Logistics Services, dba Vanguard...

  19. 77 FR 59193 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-09-26

    ... Type: New OFF License. Bring Logistics US, Inc. (NVO & OFF), 4500 N. Sam Houston Parkway W., 130...: New NVO & OFF License. Contract Logistics, LLC (NVO & OFF), 4911 N. Portland Avenue, Suite 200.... Roush, Manager, Application Type: New NVO & OFF License. Crescent Line Inc. dba Globe Express Services...

  20. 76 FR 79682 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-22

    ... at (202) 523-5843 or by email at [email protected] . A.C.T. Logistics, LLC (NVO), 154-09 146th Avenue, 3rd...-President/Secretary. Application Type: License Transfer. Canyon Global Logistics, LLC (NVO & OFF), 2928-B..., General Manager, (Qualifying Individual), Oleg Ardachev, President. Application Type: New OFF License...

  1. 76 FR 70145 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-11-10

    ...). Application Type: New NVO License. Alomar Transport, Inc. (NVO & OFF), 150-30 132nd Avenue, Suite 303, Jamaica... & OFF License. Forward System Logistics Inc. (NVO), 144-54 156th Street, Jamaica, NY 11434. Officers... NVO License. Green Line Shipping & Logistics Services Inc. (NVO & OFF), 16230 Lake View Lane, Apple...

  2. PROCESS FOR LICENSE APPLICATION DEVELOPMENT FOR THE GEOLOGIC REPOSITORY

    International Nuclear Information System (INIS)

    DOUGLAS M. FRANKS AND NORMAN C. HENDERSON

    1997-01-01

    The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the U.S. Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, (section)60.21ff and (section)60.31ff. This paper discusses the process the Yucca Mountain Site Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the ''Technical Guidance Document for Preparation of the License Application'' (TGD), currently in development

  3. Process for license application development for the geologic repository

    International Nuclear Information System (INIS)

    Franks, D.M.; Henderson, N.C.

    1998-01-01

    The Department of Energy (DOE), specifically the Office of Civilian Radioactive Waste Management (OCRWM) has been charged by the US Congress, through the Nuclear Waste Policy Act (NWPA), with the responsibility for obtaining a license to develop a geologic repository. The NRC is the licensing authority for geologic disposal, and its regulations pertinent to construction authorization and license application are specified in 10 CFR Part 60, Disposal of High-Level Radioactive Wastes in Geologic Repositories, section 60.21ff and section 60.31ff. This paper discusses the process the Yucca Mountain Site Characterization Project (YMP) will use to identify and apply regulatory and industry guidance to development of the license application (LA) for a geologic repository at Yucca Mountain, Nevada. This guidance will be implemented by the Technical Guidance Document for Preparation of the License Application (TGD), currently in development

  4. 76 FR 30360 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-05-25

    .... Application Type: Trade Name Change. B&O Logistics, Inc. (NVO), 19310 Pacific Gateway Drive, Torrance, CA.... Application Type: New NVO License. Charity Cargo L.L.C. (NVO & OFF), 1423 Kaleilani Street, Pearl City, HI... License. GreenLine Trade, LLC dba GreenLine Logistics (OFF), 14205 SE 36th, Suite 100, Bellevue, WA 98006...

  5. 77 FR 71002 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-28

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . 5G Logistics Solutions LLC..., President. Application Type: New NVO & OFF License. Bennett International Transport, L.L.C. (NVO & OFF.... Castano, COO. Application Type: New NVO & OFF License. James J. Boyle & Co. dba JJB Global Logistics Co...

  6. 21 CFR 515.11 - Supplemental medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Supplemental medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Applications § 515.11 Supplemental medicated feed mill license applications. (a) After approval of a medicated feed...

  7. 78 FR 66713 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-06

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . Action One Logistics, Inc..., Operating Manager (QI), Joseph Lam, Member, Application Type: New NVO License. Altex US, LLC (NVO & OFF), 1... President, Application Type: New NVO & OFF License. Andes Logistics USA LLC (NVO & OFF) 7500 NW 25 Street, 7...

  8. 78 FR 20106 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-04-03

    ... M. Tsai, President (QI). Application Type: New NVO License. American International Shipping Company... Type: New NVO License. Nippon Concept America, LLC (OFF), 2203 Timberloch Place, Suite 218D, The...

  9. 47 CFR 87.47 - Application for a portable aircraft station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Application for a portable aircraft station... SPECIAL RADIO SERVICES AVIATION SERVICES Applications and Licenses § 87.47 Application for a portable aircraft station license. A person may apply for a portable aircraft radio station license if the need...

  10. 75 FR 48686 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-08-11

    ...: New NVO License. Maritime and Intermodal Logistics Systems, Inc. dba MILS dba Fesco Integrated..., Senior Vice President/General Manager (Qualifying Individual), Kenryo Senda, President/CEO, Application...: New NVO & OFF License. Rado International, Inc. dba Rado Logistics (NVO & OFF), 2251 Sylvan Road...

  11. 77 FR 18815 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-28

    ... NVO License. American Patriot Lines, Inc. dba Tier One Logistics (NVO), 8616 La Tijera Boulevard, 401..., AL 36608. Officer: Samford T. Myers, Manager (Qualifying Individual). Application Type: New NVO & OFF License. Bluesea Logistics Corporation (NVO), 327 Elizabeth Avenue, Apt. A, Monterey Park, CA 91755-2044...

  12. 77 FR 43599 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-07-25

    ... OFF License. Logistics International Parcel Shipping Transport LLC (NVO), 182 West Melrose Avenue, 2... Schwartz, Director, Application Type: New OFF License. Brox Logistics USA, LLC (NVO,) 244 5th Avenue, V-280... Agency Corporation, dba C&F Worldwide Logistics. Cargois Inc. dba Star Vision Logis (NVO), 2700 Coyle...

  13. 76 FR 28778 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-05-18

    ... Individual), Application Type: New NVO & OFF License. Asian Link Logistics, LLC dba Best Global (NVO & OFF... Type: New NVO License. Hansa Meyer Global Transport USA, LLC dba Hansa Shipping LLC, (OFF), 712 Main... & Logistics (Private) Limited dba, Nashrah Shipping and Logistics (NVO), Mezzanine Floor, Trade Ave., Tower 1...

  14. Licensing process for future applications of advanced-design nuclear reactors

    International Nuclear Information System (INIS)

    Miller, C.L.

    1990-01-01

    The existing 10CFR50 two-step licensing process in the Code of Federal Regulations can continue to be a viable licensing vehicle for future applications, at least for the near future. The US Nuclear Regulatory Commission (NRC) Commissioners and staff, the public, and the utilities (along with supporting architect/engineers and nuclear steam supply system vendors) have a vast body of experience and knowledge of the existing part 50 licensing process. All these participants are familiar with their respective roles in this process, and history shows this process to be a workable licensing vehicle. Nevertheless, the use of 10CFR52 should be encouraged for future applications. This proposed new rule is intended to achieve the early resolution of licensing issues, to reduce the complexity and uncertainty of the licensing process, and enhance the safety and reliability of nuclear power plants. Part 52's overall purpose is to improve reactor safety and streamline the licensing process by encouraging the use of standard reactor designs and by allowing the early resolution of site environmental and reactor safety issues. The public should be afforded an earlier entry into the licensing process as a result of design certification rulemaking process and combined construction permit/operating license hearings

  15. 75 FR 80499 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-12-22

    ... Individual), Jeffrey Cullen, President. Application Type: QI Change. Cala Distribution, LLC (NVO), 2705 NW..., (Qualifying Individual), William S. Askew, Manager. Application Type: New NVO License. Encar Trading, Corp...

  16. License application approach for the California LLRW disposal facility

    International Nuclear Information System (INIS)

    Gaynor, R.K.; Romano, S.A.; Hanrahan, T.P.

    1990-01-01

    US Ecology, Inc. is the State of California's license designee to site, develop and operate a low-level radioactive waste (LLRW) disposal facility to serve member states of the Southwestern Compact. US Ecology identified a proposed site in the Ward Valley of southeastern California in March 1988. Following proposed site selection, US Ecology undertook studies required to prepare a license application. US Ecology's license application for this desert site was deemed complete for detailed regulatory review by the California Department of Health Services (DHS) in December 1989. By mutual agreement, disposal of mixed waste is not proposed pending the State of California's decision on appropriate management of this small LLRW subset

  17. 21 CFR 515.20 - Approval of medicated feed mill license applications.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Approval of medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.20 Approval of medicated feed mill license applications. Within 90 days after an...

  18. 78 FR 21930 - Aquenergy Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2013-04-12

    ... Systems, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and Approving Use of the Traditional Licensing Process a. Type of Filing: Notice of Intent to File License...: November 11, 2012. d. Submitted by: Aquenergy Systems, Inc., a fully owned subsidiaries of Enel Green Power...

  19. 76 FR 22104 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-20

    ...), Application Type: Business Structure Change Foothills Logistics, Inc. (NVO), 2045 John Crosland Jr. Way... Individual), Daniel Gelpi, President, Application Type: Add NVO Service ADM Logistics, Inc. (NVO & OFF), 4666... (Qualifying Individual), Application Type: New NVO & OFF License ATC Logistics, Inc. (NVO & OFF), 14350...

  20. 78 FR 50054 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-16

    ...), Ross V. Stemmler, President, Application Type: QI Change. Dawson Logistics, Inc. (OFF), 2220 South... (QI), Chad Earwood, President, Application Type: Add NVO Service. Fesco Integrated Transport North...), Ugochukwu O. Ene, President, Application Type: New NVO & OFF License. Icon Logistics Services LLC (OFF...

  1. 78 FR 37324 - Preparation of Environmental Reports for Nuclear Power Plant License Renewal Applications

    Science.gov (United States)

    2013-06-20

    ... Environmental Reports for Nuclear Power Plant License Renewal Applications AGENCY: Nuclear Regulatory Commission... for Nuclear Power Plant License Renewal Applications.'' This regulatory guide provides guidance to... renewal of a nuclear power plant operating license. Applicants should use this regulatory guide when...

  2. 78 FR 17205 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-20

    .... Sicilia, Member, Application Type: New NVO & OFF License. Brookfield Relocation Inc. (OFF), Two Corporate... Schwartz, President, Application Type: QI Change. Covenant Global Logistics Inc (NVO & OFF), 440 Benmar..., President, Application Type: Add Trade Name CGL Shipping. EXL Logistics, Inc. (NVO), 1444 NW 82nd Avenue...

  3. 78 FR 75345 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-12-11

    .... Romero, President (QI). Application Type: New NVO & OFF License. F.H.L. Logistics, Inc. (NVO & OFF), 1354.... Officers: Arif H. Butt, General Manager (QI), Unni Krishnan Nair, President. Application Type: New NVO...: Stephen F. Crooks, Vice President (QI), Scott Kelly, President. Application Type: Adding NVO Service...

  4. 15 CFR 748.9 - Support documents for license applications.

    Science.gov (United States)

    2010-01-01

    ... licensing action, since end-uses and other considerations are important factors in the decision making... promptly notifying BIS of any change in the facts contained in the support document that comes to your attention. (h) Effect on license application review. BIS reserves the right in all respects to determine to...

  5. Other best-estimate code and methodology applications in addition to licensing

    International Nuclear Information System (INIS)

    Tanarro, A.

    1999-01-01

    Along with their applications for licensing purposes, best-estimate thermalhydraulic codes allow for a wide scope of additional uses and applications, in which as realistic and realizable results as possible are necessary. Although many of these applications have been successfully developed nowadays, the use of best-estimate codes for applications other than those associated to licensing processes is not so well known among the nuclear community. This issue shows some of these applications, briefly describing their more significant and specific features. (Author)

  6. 77 FR 37044 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-20

    ... 95695, Officer: Nasrullah Chaudhry, Member/Manager (Qualifying Individual), Application Type: Add NVO... (Qualifying Individual), Margaret Kong, CFO/Secretary, Application Type: New NVO & OFF License. FSG Logistics (USA), Inc. dba FSG Logistics, Inc. (NVO & OFF), 27013 Pacific Highway South, PMB386, Des Moines, WA...

  7. 76 FR 55909 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-09-09

    ..., LLC dba AIM Global Logistics (NVO & OFF), 6402 Teluco Street, Houston, TX 77055, Officer: Angelica Garcia-Dunn, Manager/President/Treasurer (Qualifying Individual), Application Type: New OFF & NVO License... Individual), Application Type: Name Change. BestOcean Worldwide Logistics, Inc. (NVO & OFF), 1300 Valley...

  8. 78 FR 18592 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-27

    ...), Veronica Alcestte, Manager, Application Type: New NVO & OFF License Worldcraft Logistics LLC (NVO & OFF.... Salvat, Vice President, Application Type: Add NVO Service Bayshore Logistics & Services, LLC (NVO & OFF), 909 Westfield Avenue, Elizabeth, NJ 07208, Officers: Raquel Velez, Operating Manager (QI), Jose Moreno...

  9. 76 FR 62407 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-07

    ... & Product Logistics Manager (Qualifying Individual), Thomas B. Crowley, Director, Application Type: QI... at (202) 523-5843 or by e-mail at [email protected] . Alltransport International Logistics, Inc. (NVO), 63... Individual), Application Type: New NVO License. American Global Logistics LLC dba AGL (NVO & OFF), 3399...

  10. 77 FR 40882 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-07-11

    ..., Director, Application Type: License Transfer & QI Change. Gulf Premier Logistics LLC (NVO & OFF), 340 N... & OFF), 1163 Fairway Drive, 106, City of Industry, CA 91789, Officer: XiuJi Zhang, President, (Qualifying Individual), Application Type: Add NVO Service. Simple Logistics Inc. (NVO), 147-35 Farmers...

  11. 75 FR 20997 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-04-22

    ... 77354. Officers: Thomas C. Gaze, President, Qualifying Individual). Lori L. Gaze, Secretary/Treasurer... Services, (Qualifying Individual). George T. Cook, President/Treasurer, Application Type: New OFF License...

  12. 78 FR 48435 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-08

    ... Change. Ever Line Logistics Inc. (NVO & OFF), 147-35 Farmers Blvd., Suite 208, Jamaica, NY 11434, Officer: Caihong Yang, President (QI), Application Type: Name Change to Bona Logistics US Inc. Global Container.... Bote, Member/Manager, Edgar T. Bote, Member/Manager, Application Type: New NVO License. National Air...

  13. 78 FR 14792 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-03-07

    ...: Mohamed Y. Ali, Manager (QI); Abdul S. Mohamed, Member. Application Type: Add Trade Name Compass Logistics... Ugueto, Secretary. Application Type: New NVO & OFF License American Forwarding & Logistics, LLC (NVO & OFF), 1919 NW 19th Street, Unit 624, Ft. Lauderdale, FL 33311. Officers: Gabriele Awada, Manager (QI...

  14. 77 FR 45610 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-08-01

    ...), Richard A. Arkey, Vice President, Application Type: New NVO License. Aequus Worldwide Logistics Inc. (NVO..., Application Type: Name Change to Concepts in Freight, Inc. FGN Global Logistics, Inc. (NVO & OFF), 4770...), 341 Erickson Avenue, P.O. Box 124, Essington, PA 19029, Officers: Ari M. Bobrow, Export Manager...

  15. 77 FR 38288 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-27

    ..., President. Application Type: QI Change. Freight Logistics Services USA Forwarding Ltd (OFF), 15955 W. Hardy... Individual). Application Type: Add OFF Service. Pudong Prime Int'l Logistics, Inc. (NVO), 9660 Flair Drive... License. Benchmark Worldwide Logistics, Inc. dba Star Ocean Lines (NVO & OFF), 24900 South Route 53...

  16. 78 FR 48870 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-08-12

    ...: Tufan Duygun, Manager (QI), Ozisik Serhat, Member, Application Type: Add Trade Name Daimon Logistics USA. Logistics International Parcel Shipping Transport LLC (NVO), 391 Kent Avenue, Elk Grove, IL 60007, Officers...), Application Type: NVO & OFF License. Kesco Logistics, Inc. (NVO & OFF), 20 E. Sunrise Highway, Suite 308...

  17. Application of IC Card License for Road Transportation in Commercial Vehicles Supervision and Service

    Directory of Open Access Journals (Sweden)

    Li Weiwei

    2016-01-01

    Full Text Available IC card electronic license for road transport includes the IC card commercial vehicle’s certificate and IC card practitioner’s qualification certificate. In China, the IC card electronic license for road transport is the electronic ID card which must be carried by each commercial vehicles and practitioners. This paper briefly introduces the basic situation, data format and security keys architecture of IC card electronic license for road transportation of China. In order to strengthen the supervision and service of commercial vehicles, this paper puts forward the overall application framework of IC card electronic license for road transport. The application examples of IC card license in the supervision of passenger station, dangerous goods transport management, governance overload and logistics park and port area management are discussed. The practical application results show that the application of IC card electronic license for road transport is an important technical means to improve the supervision ability and service quality of the road transportation industry.

  18. NPP long term operation in Spain - First application for license renewal

    International Nuclear Information System (INIS)

    Francia, L.; Gorrochategui, I.; Marcos, R.

    2007-01-01

    Full text: In the operation of the Spanish nuclear power plants (NPP), safety is always the prime consideration. Plant Life Management Programmes have been set up with the strategic objective to operate the NPPs as long as they are considered safe and reliable. The safety of each NPP is reviewed by the Spanish nuclear regulatory authority (CSN) under a continuous process. In addition, experience is gained from operating the plants and from exchanges with operators of similar units. Current Spanish regulatory framework for renewing NPP operating licenses requires performing a Periodic Safety Review (PSR) to be performed every 10 years and submitted when applying for a new renewal of the NPP operating license. A few years ago, CSN issued a document regarding the licensing requirements that nuclear power plants should meet in order to be granted with an operating license for long term operation (i.e, operation beyond the original plant design life, typically 40 years). Besides the traditional PSR requirements, specific requirements regarding to long term operation (LTO) include: - An Aging Management and Evaluation Program, including the identification and evaluation of Time Limited Aging Analysis (TLAA). - An updated Radiological Impact Study. - A review and assessment of regulation/standard applicability. Garona NPP (GE, BWR/3 design) operated by Spanish utility Nuclenor from 1971 has a current operating license up to 2009. A decision was made to apply for a new operating license, being Garona plant the first one in Spain to face with the new long term operation requirements. The paper will provide an overview of the methodology used in Spain to address and perform the required analyses to support the LTO application for the operating license renewal. In particular, focus will be paid on the project developed in Garona (2002-2006) whose result has been the first Spanish application for License Renewal for LTO. Also it will be reported the ongoing work necessary to

  19. 78 FR 55698 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-09-11

    ...), Karla Costilla, Member/Manager, Application Type: New NVO & OFF License. ICAT Logistics, Inc. (OFF..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . Abaco Logistics Corporation..., CFO, Application Type: QI Change & Add OFF Service. American General Logistics, Inc. (NVO), 626 N...

  20. 75 FR 57798 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-09-22

    ..., (Qualifying Individual). Application Type: New NVO & OFF License. Cambria Global Logistics, LLC (OFF), 12140...). Application Type: QI Change. K&K Express, LLC dba K2 Logistics (NVO & OFF), 2980 Commers Drive, 100, Eagan, MN... Global Transport (NVO), 8636 York Circle, La Palma, CA 90623. Officer: Smile Cha, Sole Proprietor...

  1. 77 FR 12583 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-01

    ... Hermo, Vice President, Application Type: New NVO & OFF License. B2B Global Logistics Incorporated (NVO... Change. Global Logistics New Jersey Limited Liability Company (NVO & OFF) 275 Veterans Boulevard...

  2. 76 FR 47182 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-08-04

    ... Street, Tampa, FL 33619, Officers: Margara L. Barillas, President (Qualifying Individual), Danihel I. Barillas, Secretary, Application Type: New NVO License. Russell A. Farrow (U.S.) Inc. (OFF & NVO), 4950...

  3. 77 FR 26008 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-02

    .... Forth-Matthews, President, Application Type: New OFF License. Azimuth Lines Inc. (OFF), 111 Ivy Lane.... (NVO), 1000 Lakes Drive, 260, West Covina, CA 91760, Officers: Larry Lee, Treasurer (Qualifying...

  4. 76 FR 67730 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-02

    ..., President, Application Type: Name Change/Trade Name Change Lion Transport, Inc. dba Amex Logistics (NVO... Individual), Caetano R. Lopes, Vice President, Application Type: Add NVO Service Eztrans Logistics Ltd. (NVO... Type: New OFF License LF Freight USA LLC dba LF Logistics dba LF Freight dba IDS Logistics USA, dba IDS...

  5. 77 FR 30530 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-05-23

    ... Individual), Application Type: New NVO License. Global Wine Logistics, Inc. (NVO & OFF), 197 Route 19 South... Hextall, President/CEO, Application Type: Add NVO Service/Trade Name Change. M & D Global Logistics, Inc... Service. Metro Freight Services, Inc. dba Maritime Express Lines (M.E.L.) (NVO & OFF), 1225 W. St. George...

  6. 77 FR 72863 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-12-06

    ... & D Transport, Inc. (NVO & OFF), 4869 Peavey Drive, Meridian, MS 39301. Officers: Uros Pejanovic, Vice... Nucete, Director. Application Type: New NVO & OFF License. Embarque Los Hidalgos LLC (NVO & OFF), 326...

  7. 76 FR 78007 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-15

    ..., (Qualifying Individual), Ruba Hindi, Member, Application Type: New OFF License. Kemka USA Limited Liability Company (NVO & OFF), 421 Lucy Court, South Plainfield, NJ 07080, Officer: Hsiang (Rita) Y. Hsiao, Member...

  8. 76 FR 56759 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-09-14

    ...), Ariel S. Villamayor, Limited Partner, Application Type: New OFF License. UTi, United States, Inc. dba UTi (NVO & OFF), 1660 Walt Whitman Road, Melville, NY 11747. Officers: Charles N. Deller, Vice...

  9. 75 FR 67973 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-04

    ... Individual), Joy V. Pareckattil, President/Director, Application Type: New NVO License. CJC Logistics Limited Liability Company dba CJC Container Line (NVO & OFF), 186 Alps Road, Wayne, NJ 07470. Officers: Oliver Rosca...

  10. 77 FR 70162 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-11-23

    ...), 900 Center Park Drive, Suite F, Charlotte, NC 28217, Officers: Paul L. Carter, Vice President (QI...), Application Type: New NVO License. Transport Partner (USA), Inc. (NVO & OFF), 2006 Cherry Hill Lane...

  11. 78 FR 38336 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-26

    ..., President (QI), Stephen B. Schwark, Treasurer, Application Type: License Transfer to EFL Container Lines...., Suite K, Mobile, AL 36609, Officers: Thomas (Mac) H. McPhillips IV, Assistant Vice President (QI), Oscar...

  12. 21 CFR 515.21 - Refusal to approve a medicated feed mill license application.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Refusal to approve a medicated feed mill license... SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.21 Refusal to approve a medicated feed mill license application. (a) The...

  13. 77 FR 64991 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-24

    ..., Manager/Member. Application Type: New NVO & OFF License. Hospitality Logistics International LLC (NVO...), 11690 NW. 105th Street, Law 4W, Miami, FL 33178. Officers: Chris Merritt, Vice President (QI), John H...

  14. 76 FR 23598 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-04-27

    ... Angeles, CA 90045, Officers: Ann L. Shang, CFO (Qualifying Individual), Yon L. Li, President, Application... Type: New NVO & OFF License. PME Logistics, Inc. (NVO), 19401 S. Main Street, Suite 102, Gardena, CA...

  15. 10 CFR 781.62 - Contents of a license application.

    Science.gov (United States)

    2010-01-01

    ... royalty fees or other consideration, if any, that the applicant would be willing to pay the Government for... application. An application for a license under a DOE invention must be accompanied by a processing fee of $25... towards royalty if royalties are charged, and must include the following information: (a) Identification...

  16. 76 FR 72984 - Revised Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2011-11-28

    ... NUCLEAR REGULATORY COMMISSION Revised Application for a License To Export High-Enriched Uranium The application for a license to export high-enriched Uranium has been revised as noted below. Notice... fabricate fuel France. Security Complex; October 18, Uranium (93.35%). uranium (174.0 elements in France...

  17. Use of limited information in a license application to construct a repository

    International Nuclear Information System (INIS)

    McGarry, J.M. III; Echols, F.S.

    1996-01-01

    The purpose of this paper is to provide a rationale for the proposition that the Department of Energy's (DOE's) submittal of a license application (LA) for the construction of a geologic repository to the Nuclear Regulatory Commission (NRC) may be, and arguably must be, based on statutorily-limited site characterization data and design information. The Nuclear Waste Policy Act of 1982 (NWPA), as amended, is the controlling statute for the disposal of spent nuclear fuel in a licensed geologic repository. Applicable NRC regulations for the licensing of such a repository are found for the most part in 10 C.F.R. Part 60

  18. 10 CFR 81.40 - Contents of a license application.

    Science.gov (United States)

    2010-01-01

    ... categories: (i) Small business firm; (ii) Minority business enterprise; (iii) Location in a surplus labor... correspondence should be sent and any notices served; (4) Nature and type of applicant's business; (5...; (6) Purpose for which the license is desired, and a brief description of applicant's plan to achieve...

  19. License renewal - an idea whose time has come. Hatch nuclear plant license renewal program: an actual example of application of the license renewal rule to the Intake Structure

    International Nuclear Information System (INIS)

    Chandiwala, F.; Evans, W.P.

    1999-01-01

    After the NRC issued a revised license renewal rule in May 1995, the nuclear industry focussed on developing generic industry for implementing the rule and testing the guidance through various demonstration programs and work products in conjunction with the NRC. In addition, plant-specific programs also proceeded forward. These activities show that implementation issues continue to exist. Since the issuance of the rule, the NRC has issued a draft standard review plan for license renewal (SRP-LR), working draft, September 1997. Southern Nuclear Operating Company (SNC) has begun development work on a license renewal application for Plant Hatch Units 1 and 2. Plant Hatch Units 1 and 2 are BWR 4, Mark I plants whose operating licenses expire in 2014 and 2018, respectively. The Plant Hatch initiative also involves teaming with other boiling water reactors (BWRs) to develop the license renewal technology within the BWR fleet, and to support Plant Hatch by providing an oversight role for the application process. The teaming effort involved two other utilities, each being assigned to prepare a common report on a mechanical system or a structure. The common report could be presented to the NRC with modifications to suit the individual plants, thereby saving time and money, and hopefully resulting in quicker approval by the NRC. The desired license renewal process end result is a renewed license with up to a 20 year extension (10CFR 54.31(b)). (orig.)

  20. 76 FR 65544 - Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities

    Science.gov (United States)

    2011-10-21

    ... NUCLEAR REGULATORY COMMISSION [NRC-2009-0323] Standard Format and Content of License Applications... revision to regulatory guide (RG) 3.39, ``Standard Format and Content of License Applications for Mixed Oxide Fuel Fabrication Facilities.'' This guide endorses the standard format and content for license...

  1. 76 FR 59173 - Standard Format and Content of License Applications for Conventional Uranium Mills

    Science.gov (United States)

    2011-09-23

    ... NUCLEAR REGULATORY COMMISSION [NRC-2008-0302] Standard Format and Content of License Applications for Conventional Uranium Mills AGENCY: Nuclear Regulatory Commission. ACTION: Draft regulatory guide..., ``Standard Format and Content of License Applications for Conventional Uranium Mills.'' DG- 3024 was a...

  2. 76 FR 6135 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-02-03

    ... Lawin Cargo dba, Bahaghari Express Cargo (NVO), 761 Highland Place, San Dimas, CA 91773, Officer..., Application Type: New NVO License. Four Points Ocean Inc. (NVO & OFF), 1460 Route 9 North, Suite 303.... Grannell, President/CEO (Qualifying Individual), Michael Kuhn, Vice President, Sales & Marketing...

  3. 76 FR 3636 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-01-20

    ..., Vice President, Application Type: New NVO & OFF License. CDS Global Logistics, Inc. (NVO & OFF), 1001... & Logistics LLC (NVO & OFF), Hoboken Business Center, 50 Harrison Street, Suite 204B, Hoboken, NJ 07030, Officers: Michelle L. Hasenauer, Manager (Qualifying Individual), Harbans S. Shrinkant, Manager...

  4. 75 FR 29545 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-05-26

    .... Atlantic Cargo Logistics LLC (OFF & NVO), 120 South Woodland Blvd., 216, Deland, FL 32720. Officers: Dietmar Lutte, Manager, (Qualifying Individual) Susan Lutte, Member, Application Type: New OFF & NVO License. Direct Delivery Logistics and Supply, LLC (OFF & NVO) 2006 Wilson Road, Humble, TX 77396...

  5. 76 FR 7209 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-02-09

    ... 77032. Officer: Walter Krauklis, OTI Compliance Officer (Qualifying Individual), Thomas B. Crowley, Jr... Road, Suite 14, Newtown Square, PA 19073. Officer: Thomas D. Torcomian, CEO/ Member (Qualifying...). Application Type: New OFF License. Solomon Emeke dba Desaiah Limited (OFF), 3696 Park Avenue, 300, Ellicott...

  6. 21 CFR 515.25 - Revocation of order refusing to approve a medicated feed mill license application or suspending...

    Science.gov (United States)

    2010-04-01

    ... medicated feed mill license application or suspending or revoking a license. 515.25 Section 515.25 Food and..., FEEDS, AND RELATED PRODUCTS MEDICATED FEED MILL LICENSE Administrative Actions on Licenses § 515.25 Revocation of order refusing to approve a medicated feed mill license application or suspending or revoking a...

  7. 75 FR 35815 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-06-23

    ..., TX 76011. Officers: Omar Kolaghassi, Manager (Qualifying Individual), Laura Alicia, Manager. Application Type: New OFF & NVO License. CALS Logistics USA, Inc. (OFF & NVO), 755 North Route 83, Suite 215.... Premium Star Logistics LLC dba O.P. Premium Star Logistics (OFF & NVO), 4200 Lightning Court, Bakersfield...

  8. 76 FR 16420 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-03-23

    ...), Andrew P. Bottomley, Managing Partner, Application Type: QI Change and Add OFF Service. All Transport... Type: New NVO & OFF License. Andrea Bigi dba AB Global Logistics Consulting (OFF), 1010 19th Street, 10.... Officers: Joanne Kirkpatrick, International Logistics Officer (Qualifying Individual), Jack R. Lentz, CEO...

  9. Application of up-front licensing

    Energy Technology Data Exchange (ETDEWEB)

    Grant, S D [Atomic Energy of Canada Ltd., Saskatoon, SK (Canada); Snell, V G [Atomic Energy of Canada Ltd., Mississauga, ON (Canada)

    1996-12-31

    AECL has been pioneering `up-front` licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs.

  10. Application of up-front licensing

    International Nuclear Information System (INIS)

    Grant, S.D.; Snell, V.G.

    1995-01-01

    AECL has been pioneering 'up-front' licensing of new reactor designs. The CANDU 3 design has been formally reviewed by AECB staff for a number of years. The CANDU 9 design has just started the up-front licensing process. The process gives designers, regulators and potential customers early confidence in the licensability of future plants. (author). 4 refs., 2 tabs

  11. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    1991-04-01

    The Department of Energy (DOE) Order DOE 5480.6, Safety of Department of Energy-Owned Nuclear Reactors, establishes reactor safety requirements to assure that reactors are sited, designed, constructed, modified, operated, maintained, and decommissioned in a manner that adequately protects health and safety and is in accordance with uniform standards, guides, and codes which are consistent with those applied to comparable licensed reactors. This document identifies nuclear safety criteria applied to NRC [Nuclear Regulatory Commission] licensed reactors. The titles of the chapters and sections of USNRC Regulatory Guide 1.70, Standard Format and Content of Safety Analysis Reports for Nuclear Power Plants, Rev. 3, are used as the format for compiling the NRC criteria applied to the various areas of nuclear safety addressed in a safety analysis report for a nuclear reactor. In each section the criteria are compiled in four groups: (1) Code of Federal Regulations, (2) US NRC Regulatory Guides, SRP Branch Technical Positions and Appendices, (3) Codes and Standards, and (4) Supplemental Information. The degree of application of these criteria to a DOE-owned reactor, consistent with their application to comparable licensed reactors, must be determined by the DOE and DOE contractor

  12. 77 FR 65887 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-10-31

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . ACM Logistics & Consulting... Type: New OFF License; Highland Project Logistics, Inc. (NVO & OFF), 35 Constitution Drive, Suite A.... Bonner, Special Manager (QI), Martine L. Plunkett, Manager, Application Type: Additional QI; Radiant...

  13. 77 FR 74186 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2012-12-13

    ... Logistics, Inc. (NVO & OFF), 7685 NW. 80th Terrace, Medley, FL 33166, Officers: Hugo E. Martinez, Secretary... & OFF), 1834 Harden Blvd., Lakeland, FL 33803, Officers: Steven C. Pniewski, Manager (QI), Manuel R. Echevarria, President, Application Type: New NVO & OFF License, Global Wide Logistics, Inc. (NVO), 1937 Davis...

  14. 78 FR 43202 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-07-19

    .... Alsea Global Logistics, LLC dba Alsea Global Logistics (NVO & OFF), 4836 SE Powell Blvd., Portland, OR... NVO & OFF License. Atlant Consulting Inc. dba Avro Logistics (NVO & OFF), 3626 Geary Blvd., Suite 206..., Officers: Paul Selvage, Member (QI), Steven Periman, Member/Manager, Application Type: Add Trade Name Blu...

  15. 76 FR 33757 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-06-09

    ... NVO & OFF License. The Ultimate Logistics Service Corporation (NVO & OFF), 3 Birch Place, Pine Brook... Logistics, Corp. (NVO), 4713 Deeboyar, Lakewood, CA 90712. Officer: Tan Sek, Pres/VP/Sec/Treasurer...), Application Type: Add OFF Service. Oceanic Link USA LLC (NVO & OFF), 5430 Jimmy Carter Blvd., Suite 216...

  16. 77 FR 13604 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-03-07

    ... A. Rincon, Manager (Qualifying Individuals), Application Type: Business Structure Change. De Well... Type: New NVO License. King Solomon Logistics Inc. (NVO), 135-14 Liberty Avenue, South [[Page 13605... Logistics Inc. (NVO), 167-16 146th Avenue, Suite 203, Jamaica, NY 11434, Officer: Yau Fung Ling, President...

  17. Licensed reactor nuclear safety criteria applicable to DOE reactors

    International Nuclear Information System (INIS)

    1993-11-01

    This document is a compilation and source list of nuclear safety criteria that the Nuclear Regulatory Commission (NRC) applies to licensed reactors; it can be used by DOE and DOE contractors to identify NRC criteria to be evaluated for application to the DOE reactors under their cognizance. The criteria listed are those that are applied to the areas of nuclear safety addressed in the safety analysis report of a licensed reactor. They are derived from federal regulations, USNRC regulatory guides, Standard Review Plan (SRP) branch technical positions and appendices, and industry codes and standards

  18. Standard format and content for a license application to store spent fuel and high-level radioactive waste

    International Nuclear Information System (INIS)

    1989-09-01

    Subpart B, ''License Application, Form, and Contents,'' of 10 CFR Part 72, ''Licensing Requirements for the Independent Storage of Spent Nuclear Fuel and High-Level Radioactive Waste,'' specifies the information to be covered in an application for a license to store spent fuel in an independent spent fuel storage installation (ISFSI) or to store spent fuel and high-level radioactive waste in a monitored retrievable storage facility (MRS). However, Part 72 does not specify the format to be followed in the license application. This regulatory guide suggests a format acceptable to the NRC staff for submitting the information specified in Part 72 for license application to store spent fuel in an ISFSI or to store spent fuel and high-level radioactive waste in an MRS

  19. 76 FR 79203 - Prospective Grant of Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines

    Science.gov (United States)

    2011-12-21

    ... Exclusive License: Veterinary Biological Products for Swine Influenza Vaccines AGENCY: National Institutes....7. The invention relates to compositions and methods of use as Veterinary Influenza Vaccines... to humans. This technology describes DNA vaccines against influenza serotypes H5N1, H1N1, H3N2, and...

  20. 77 FR 35384 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-06-13

    ... Logistics LLC (NVO), 9814 Goldenglade Drive, Houston, TX 77064, Officer: Sandra Lesage, Member/Manager... telephone at (202) 523-5843 or by email at [email protected] . ABC Trucking and Logistics L.L.C. (OFF), 3080...), Lawrence R. Lammers, President/CEO, Application Type: License Transfer Atlantic Cargo Logistics LLC (NVO...

  1. 76 FR 38651 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-07-01

    ... Shipping (NVO), 1861 Western Way, Torrance, CA 90501. Officers: Hseanrus (Stephen) H. Lin, President/Vice..., President, Application Type: New NVO & OFF License. F.H.L. Logistics, Inc. (NVO & OFF), 1354 NW 78th Avenue..., Gardena, CA 90248. Officers: Anna W. Liu, Vice President (Operations), (Qualifying Individual), Quincy H...

  2. 77 FR 39707 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-07-05

    ..., Application Type: New OFF License. Best Global Logistics USA, Inc dba Siam Intercargo Services (NVO & OFF... International Transport, LLC (NVO), 6048 Lido Lane, Long Beach, CA 90803, Officer: Charles Brennan, Member...: Add NVO Service. Sinai Logistics LLC (NVO & OFF), 11419 NW. 112th Street, Medley, FL 33178, Officer...

  3. Resolving the issues arisen during the development of License Renewal Application at PAKS NPP

    International Nuclear Information System (INIS)

    Ratkai, Sandor; Katona, Tamas Janos

    2012-01-01

    Operational license of the four VVER-440/213 units at Paks NPP, Hungary is limited to the design lifetime of 30 years. Extension by an additional 20 years of the original license is one of the main goals of the plant owner. In 2008 a programme for long-term operation (LTO) was developed and submitted to the Hungarian Atomic Energy Authority. The LTO Programme defines the activities for ensuring the extension of the operational lifetime and contains the justification of the safe LTO. The LTO Programme has to be implemented and comprehensive justification of the safe LTO has to be provided in the formal License Renewal Applications unit by unit. This work has been completed by the end of 2011, and the application has been submitted for approval for the Unit 1. The authority review and the approval of the License Renewal Application for Unit 1 should be finished before the expiration of the original design lifetime in 2012. In line with the regulations and supporting the License Renewal Application, a large number of engineering tasks have been performed. In this paper the entire project will be reported. The issues will be discussed, which have been arisen during the development of the application. The difficulties caused by the Hungarian technical and regulatory peculiarities will be presented. (author)

  4. 78 FR 73566 - Standard Format and Content for a License Application for an Independent Spent Fuel Storage...

    Science.gov (United States)

    2013-12-06

    ... NUCLEAR REGULATORY COMMISSION [NRC-2013-0264] Standard Format and Content for a License...), DG-3042, ``Standard Format and Content for a License Application for an Independent Spent Fuel..., Form, and Contents,'' specifies the information that must be in an application for a license to store...

  5. 76 FR 41258 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-07-13

    ... Individual), Gediminas Garmus, Member/Manager. Application Type: New OFF License. World Logistics USA, Inc... at (202) 523-5843 or by e-mail at [email protected] . 3 Plus Logistics Co. dba Touchdown Freight Co. (NVO... Logistics, Inc. (NVO), 3120 Via Mondo, Rancho Dominguez, CA 90220. Officer: Simon Hwang, President/CEO...

  6. Fort Calhoun Station, Unit 2. License application, PSAR, general information

    International Nuclear Information System (INIS)

    1975-09-01

    Application for construction and operating licenses for Calhoun-2 Reactor is presented. Financial data concerning the Omaha Public Power District and the Nebraska Public Power District are included. (DCC)

  7. 78 FR 35634 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-06-13

    ..., Washington, DC 20573, by telephone at (202) 523-5843 or by email at [email protected] . China Interocean Transport.... Taleon, Sole Proprietor (QI). Application Type: New NVO & OFF License. Dulce Auto Import & Export, Inc...), Parque de Granada No. 71, P.H. 504, Huixquilucan, Estado de Mexico 52785 Mexico. Officers: Moises S. Leon...

  8. Export Controls: Controls Over the Export Licensing Process for Chemical and Biological Items

    National Research Council Canada - National Science Library

    2005-01-01

    .... foreign policy should read this report. The report discusses the effectiveness of the DoD review process for export license applications and updates to Federal export regulations to prevent the proliferation of items that could pose...

  9. The regulatory review of construction license application and the supporting safety case

    International Nuclear Information System (INIS)

    Heinonen, Jussi

    2014-01-01

    Finland is one of the foremost countries in the world in developing the disposal of spent fuel. The construction license application for the Olkiluoto spent fuel disposal facility was submitted to the authorities at the end of 2012 and the facility is expected to start operation around 2020. This has been a long-term project with over 30 years of parallel development of the repository project and the regulatory approach to spent fuel management. In 1983 the government made a strategic decision on the objectives and target time schedule for the research, development and technical planning of nuclear waste management. While an export and international disposal solution was still the preferred option, this decision required the licensees without this possibility to prepare for disposal in Finland and it also gave the time line for the milestones on the way to an operating disposal facility by 2020. The licensing procedure for a disposal facility has several steps that are similar to all nuclear facilities in Finland and are defined in Nuclear Energy Act and Decree (1987, 1988). These licensing steps are: - Decision-in-principle is required for a nuclear facility having considerable general significance. This is essentially a political decision: the government decides if the construction project is in line with the overall good of society. The decision can be applied for one or more sites, the host municipality has a veto right and the parliament has the choice of ratifying or not ratifying the decision. - Construction license is granted by the government and authorises the construction of the disposal facility. The actual construction is regulated by STUK and includes several review and approval steps, hold points and viewpoints. - Operational license is granted by the government and authorises the operation of the facility for a certain period. The operational license is needed before nuclear waste can be disposed. The first step in the licensing process was reached

  10. Fuel Receiving and Storage Station. License application, amendment 7

    International Nuclear Information System (INIS)

    1976-02-01

    Amendment No. 7 to Allied-General Nuclear Services application for licensing of the Fuel Receiving and Storage Station consists of revised pages for: Amendment No. 7 to AG-L 105, ''Technical Description in Support of Application for FRSS Operation''; Amendment No. 1 to AG-L 105A, ''Early Operation of the Service Concentrator''; and Amendment No. 2 to AG-L 110, ''FRSS Summary Preoperational Report.''

  11. 76 FR 14395 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-03-16

    ..., Manager/President. Application Type: QI Change. Geoffrey Au dba ABC Logistics Company (NVO), 2250 Gellert... at (202) 523-5843 or by e-mail at [email protected] . Arkman Logistics Inc. (NVO), 1001 Fargo Avenue, Elk... Type: New NVO & OFF License. BCargo Logistics, S.A. de C.V. (NVO), Av. Revolucion 725-A, Col. Jardin...

  12. 78 FR 60282 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-10-01

    ...) pursuant to section 19 of the Shipping Act of 1984 (46 U.S.C. 40101). Notice is also given of the filing of... Castleton Street, Suite 105, City of Industry, CA 91748, Officers: Ya Liu, Deputy General Manager (QI), Jian C. Feng, Director, Application Type: New NVO License, By the Commission. Dated: September 27, 2013...

  13. 76 FR 65193 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-10-20

    ... at (202) 523-5843 or by e-mail at [email protected] . AB Global Logistics Consulting Inc. (OFF), 1010 19th..., Application Type: New NVO License. All Transport Export Inc (NVO & OFF), 4224 Shackleford Road, 3, Norcross... Type: Name Change. CR & J Logistics, Inc. (OFF), 8401 Lake Worth Road, Lake Worth, FL 33467. Officers...

  14. Environmental Standard Review Plan for the review of license renewal applications for nuclear power plants

    International Nuclear Information System (INIS)

    O'Brien, J.; Kim, T.J.; Reynolds, S.

    1991-08-01

    The Environmental Standard Review Plan for the Review of License Applications for Nuclear Power Plants (ESRP-LR) is to be used by the NRC staff when performing environmental reviews of applications for the renewal of power reactor licenses. The use of the ESRP-LR provides a framework for the staff to determine whether or not environmental issues important to license renewal have been identified and the impacts evaluated and provides acceptance standards to help the reviewers comply with the National Environmental Policy Act

  15. 77 FR 35079 - License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC

    Science.gov (United States)

    2012-06-12

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-443; NRC-2010-0206] License Renewal Application for Seabrook Station, Unit 1 ; NextEra Energy Seabrook, LLC AGENCY: Nuclear Regulatory Commission. ACTION: License renewal application; intent to prepare supplement to draft [[Page 35080

  16. 75 FR 70350 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2010-11-17

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [USCG-2010-0993] Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application AGENCY: Maritime Administration... announce they have received an application for the licensing of a natural gas deepwater port and the...

  17. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    International Nuclear Information System (INIS)

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  18. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Format and Content. NUREG-1537, Part 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 1 gives guidance to non-power reactor licensees and applicants on the format and content of applications to the Nuclear Regulatory Commission for licensing actions. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  19. Licensing an assured isolation facility for low-level radioactive waste. Volume 1: Licensing strategy and issues

    International Nuclear Information System (INIS)

    Silverman, D.J.; Bauser, M.A.; Baird, R.D.

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  20. 77 FR 73054 - Application for a License To Export Radioactive Waste

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Radioactive Waste Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear..., October 25, 2012, XW020, radioactive 1178 pounds disposal by the 11006061. waste in the (approximately...

  1. 76 FR 49462 - Newfound Hydroelectric Company, KTZ Hydro, LLC; Notice of Application for Transfer of License...

    Science.gov (United States)

    2011-08-10

    ... Hydroelectric Company, KTZ Hydro, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On July 25, 2011, Newfound Hydroelectric Company (transferor) and KTZ Hydro, LLC (transferee) filed an application for transfer of license for the Newfound Hydroelectric Project...

  2. 77 FR 71404 - Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially...

    Science.gov (United States)

    2012-11-30

    ... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent to License Government-Owned Inventions; Intent to License on a Partially-Exclusive Basis AGENCY: Department of the Army, DoD. ACTION... by the Secretary of the Army. The US Army Edgewood Chemical Biological Center intends to license...

  3. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1987-05-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes

  4. Patterns of use and impact of standardised MedDRA query analyses on the safety evaluation and review of new drug and biologics license applications.

    Directory of Open Access Journals (Sweden)

    Lin-Chau Chang

    Full Text Available Standardised MedDRA Queries (SMQs have been developed since the early 2000's and used by academia, industry, public health, and government sectors for detecting safety signals in adverse event safety databases. The purpose of the present study is to characterize how SMQs are used and the impact in safety analyses for New Drug Application (NDA and Biologics License Application (BLA submissions to the United States Food and Drug Administration (USFDA.We used the PharmaPendium database to capture SMQ use in Summary Basis of Approvals (SBoAs of drugs and biologics approved by the USFDA. Characteristics of the drugs and the SMQ use were employed to evaluate the role of SMQ safety analyses in regulatory decisions and the veracity of signals they revealed.A comprehensive search of the SBoAs yielded 184 regulatory submissions approved from 2006 to 2015. Search strategies more frequently utilized restrictive searches with "narrow terms" to enhance specificity over strategies using "broad terms" to increase sensitivity, while some involved modification of search terms. A majority (59% of 1290 searches used descriptive statistics, however inferential statistics were utilized in 35% of them. Commentary from reviewers and supervisory staff suggested that a small, yet notable percentage (18% of 1290 searches supported regulatory decisions. The searches with regulatory impact were found in 73 submissions (40% of the submissions investigated. Most searches (75% of 227 searches with regulatory implications described how the searches were confirmed, indicating prudence in the decision-making process.SMQs have an increasing role in the presentation and review of safety analysis for NDAs/BLAs and their regulatory reviews. This study suggests that SMQs are best used for screening process, with descriptive statistics, description of SMQ modifications, and systematic verification of cases which is crucial for drawing regulatory conclusions.

  5. Patterns of use and impact of standardised MedDRA query analyses on the safety evaluation and review of new drug and biologics license applications.

    Science.gov (United States)

    Chang, Lin-Chau; Mahmood, Riaz; Qureshi, Samina; Breder, Christopher D

    2017-01-01

    Standardised MedDRA Queries (SMQs) have been developed since the early 2000's and used by academia, industry, public health, and government sectors for detecting safety signals in adverse event safety databases. The purpose of the present study is to characterize how SMQs are used and the impact in safety analyses for New Drug Application (NDA) and Biologics License Application (BLA) submissions to the United States Food and Drug Administration (USFDA). We used the PharmaPendium database to capture SMQ use in Summary Basis of Approvals (SBoAs) of drugs and biologics approved by the USFDA. Characteristics of the drugs and the SMQ use were employed to evaluate the role of SMQ safety analyses in regulatory decisions and the veracity of signals they revealed. A comprehensive search of the SBoAs yielded 184 regulatory submissions approved from 2006 to 2015. Search strategies more frequently utilized restrictive searches with "narrow terms" to enhance specificity over strategies using "broad terms" to increase sensitivity, while some involved modification of search terms. A majority (59%) of 1290 searches used descriptive statistics, however inferential statistics were utilized in 35% of them. Commentary from reviewers and supervisory staff suggested that a small, yet notable percentage (18%) of 1290 searches supported regulatory decisions. The searches with regulatory impact were found in 73 submissions (40% of the submissions investigated). Most searches (75% of 227 searches) with regulatory implications described how the searches were confirmed, indicating prudence in the decision-making process. SMQs have an increasing role in the presentation and review of safety analysis for NDAs/BLAs and their regulatory reviews. This study suggests that SMQs are best used for screening process, with descriptive statistics, description of SMQ modifications, and systematic verification of cases which is crucial for drawing regulatory conclusions.

  6. 77 FR 14445 - Application for a License To Export Steel Forging

    Science.gov (United States)

    2012-03-09

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Steel Forging Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the Nuclear... head steel February 7, 2012 forging. forging will be XR175 machined into the 11005983 finished vessel...

  7. 9 CFR 2.11 - Denial of initial license application.

    Science.gov (United States)

    2010-01-01

    ... have violated any Federal, State, or local laws or regulations pertaining to animal cruelty within 1... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Denial of initial license application. 2.11 Section 2.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT...

  8. Application of coupled codes for safety analysis and licensing issues

    International Nuclear Information System (INIS)

    Langenbuch, S.; Velkov, K.

    2006-01-01

    An overview is given on the development and the advantages of coupled codes which integrate 3D neutron kinetics into thermal-hydraulic system codes. The work performed within GRS by coupling the thermal-hydraulic system code ATHLET and the 3D neutronics code QUABOX/CUBBOX is described as an example. The application of the coupled codes as best-estimate simulation tools for safety analysis is discussed. Some examples from German licensing practices are given which demonstrate how the improved analytical methods of coupled codes have contributed to solve licensing issues related to optimized and more economical use of fuel. (authors)

  9. Licensing requirements for initial commissioning programs in Spain: Application to different PWR designs

    International Nuclear Information System (INIS)

    Munuera, A.; Conde, J.M.; Martinez, J.

    1991-01-01

    This paper describes the overall licensing process in Spain, focusing on the initial commissioning requirements. The significance of this part of the regulatory work is evident both from the licensing and the licensee's points of view. Licensing in Spain is ruled by different laws which determine the general requirements and fix the licensing frame. Being a nuclear technology importer country, the base of the regulatory work lies on the rules and regulations of the country of origin of the planet, with the addition of case specific requirements. The application of this methodology to plants designed in different countries produces licensing processes which are similar to the overall, but very different in its development. It also means a special technical effort on the part of the regulatory body to cope with the problems arising from the use of different technologies and safety standards. The start-up programs from fuel loading to full power of a Westinghouse plant (Vandellos 2) and a Siemens-KWU plant (Trillo 1) are compared from the technical point of view, enhancing the differences that can be relevant for the regulatory work. The difficulties arising from the application of both the German and US concepts are discussed. (orig.)

  10. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    International Nuclear Information System (INIS)

    Silverman, D.J.; Bauser, M.A.; Baird, R.D.

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application

  11. Licensing an assured isolation facility for low-level radioactive waste. Volume 2: Recommendations on the content and review of an application

    Energy Technology Data Exchange (ETDEWEB)

    Silverman, D.J.; Bauser, M.A. [Morgan, Lewis and Bockius, Washington, DC (United States); Baird, R.D. [Rogers and Associates Engineering Corp., Salt Lake City, UT (United States)

    1998-07-01

    This report provides a detailed set of proposed criteria and guidance for the preparation of a license application for an assured isolation facility (AIF). The report is intended to provide a detailed planning basis upon which a prospective applicant may begin pre-licensing discussions with the Nuclear Regulatory Commission and initiate development of a license application. The report may also be useful to the NRC or to state regulatory agencies that may be asked to review such an application. Volume 1 of this report provides background information, and describes the licensing approach and methodology. Volume 2 identifies specific information that is recommended for inclusion in a license application.

  12. Fuel Receiving and Storage Station. License application, amendment 4

    International Nuclear Information System (INIS)

    1975-04-01

    Amendment No. 4 of the application for licensing the Barnwell Fuel Processing Plant is presented. Information is included on: the quantity and characteristics of nuclear fuel assemblies which can be received and stored; specifications limiting the outside washdown of contaminated casks received for unloading; and definition of environmental monitoring program. (U.S.)

  13. License renewal process

    International Nuclear Information System (INIS)

    Fable, D.; Prah, M.; Vrankic, K.; Lebegner, J.

    2004-01-01

    The purpose of this paper is to provide information about license renewal process, as defined by Nuclear Regulatory Commission (NRC). The Atomic Energy Act and NRC regulations limit commercial power reactor licenses to an initial 40 years but also permit such licenses to be renewed. This original 40-year term for reactor licenses was based on economic and antitrust considerations not on limitations of nuclear technology. Due to this selected time period; however, some structures and components may have been engineered on the basis of an expected 40-year service life. The NRC has established a timely license renewal process and clear requirements codified in 10 CFR Part 51 and 10 CFR Part 54, that are needed to assure safe plant operation for extended plant life. The timely renewal of licenses for an additional 20 years, where appropriate to renew them, may be important to ensuring an adequate energy supply during the first half of the 21st Century. License renewal rests on the determination that currently operating plants continue to maintain adequate levels of safety, and over the plant's life, this level has been enhanced through maintenance of the licensing bases, with appropriate adjustments to address new information from industry operating experience. Additionally, NRC activities have provided ongoing assurance that the licensing bases will continue to provide an acceptable level of safety. This paper provides additional discussion of license renewal costs, as one of key elements in evaluation of license renewal justifiability. Including structure of costs, approximately value and two different approaches, conservative and typical. Current status and position of Nuclear Power Plant Krsko, related to license renewal process, will be briefly presented in this paper. NPP Krsko is designed based on NRC Regulations, so requirements from 10 CFR 51, and 10 CFR 54, are applicable to NPP Krsko, as well. Finally, this paper will give an overview of current status of

  14. 75 FR 61474 - Juneau Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2010-10-05

    ... Hydropower, Inc.; Notice of Intent To File License Application, Filing of Pre-Application Document, and....: 13563-001. c. Dated Filed: July 28, 2010. d. Submitted By: Juneau Hydropower, Inc. e. Name of Project... Commission's regulations. h. Potential Applicant Contact: Duff W. Mitchell, Juneau Hydropower, Inc., P.O. Box...

  15. Application and licensing requirements of the Framatome ANP RLBLOCA methodology

    International Nuclear Information System (INIS)

    Martin, R.P.; Dunn, B.M.

    2004-01-01

    The Framatome ANP Realistic Large-Break LOCA methodology (FANP RLBLOCA) is an analysis approach approved by the US NRC for supporting the licensing basis of 3- and 4-loop Westinghouse PWRs and CE 2x4 PWRs. It was developed consistent with the NRC's Code Scaling, Applicability, and Uncertainty (CSAU) methodology for performing best-estimate large-break LOCAs. The CSAU methodology consists of three key elements with the second and third element addressing uncertainty identification and application. Unique to the CSAU methodology is the use of engineering judgment and the Process Identification and Ranking Table (PIRT) defined in the first element to lay the groundwork for achieving the ultimate goal of quantifying the total uncertainty in predicted measures of interest associated with the large-break LOCA. It is the PIRT that not only directs the methodology development, but also directs the methodology review. While the FANP RLBLOCA methodology was generically approved, a plant-specific application is customized in two ways addressing how the unique plant characterization 1) is translated to code input and 2) relates to the unique methodology licensing requirements. Related to the former, plants are required by 10 CFR 50.36 to define a technical specification limiting condition for operation based on the following criteria: 1. Installed instrumentation that is used in the control room to detect, and indicate, a significant abnormal degradation of the reactor coolant pressure boundary. 2. A process variable, design feature, or operating restriction that is an initial condition of a design basis accident or transient analysis that either assumes the failure of or presents a challenge to the integrity of a fission product barrier. 3. A structure, system, or component that is part of the primary success path and which functions or actuates to mitigate a design basis accident or transient that either assumes the failure of or presents a challenge to the integrity of a

  16. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1983-10-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  17. Pesticide Applicator Profiling: Using Polycom[R] Distance Delivery for Continuing Education and Characterizing Florida's Licensed Applicators

    Science.gov (United States)

    Fishel, Fred; Langeland, Ken

    2011-01-01

    The University of Florida offers continuing education units (CEUs) via distance technology using Polycom[R] to meet requirements for applicators of pesticides to renew their licenses. A large statewide event conducted in 2010 also included a needs assessment of this group concerning CEUs. Results indicate that these applicators strongly prefer…

  18. Guide for the preparation of applications for licenses for the use of sealed sources in portable gauging devices

    International Nuclear Information System (INIS)

    1985-01-01

    The purpose of this regulatory guide is to provide assistance to applicants and licensees in preparing applications for new licenses, license amendments, and license renewals for the use of sealed sources in portable gauging devices. An example of a portable gauging device is a moisture-density gauge that contains a gamma-emitting sealed source, cesium-137, and a sealed neutron source, americium-242-beryllium

  19. Streamlining the license renewal review process

    International Nuclear Information System (INIS)

    Dozier, J.; Lee, S.; Kuo, P.T.

    2001-01-01

    The staff of the NRC has been developing three regulatory guidance documents for license renewal: the Generic Aging Lessons Learned (GALL) report, Standard Review Plan for License Renewal (SRP-LR), and Regulatory Guide (RG) for Standard Format and Content for Applications to Renew Nuclear Power Plant Operating Licenses. These documents are designed to streamline the license renewal review process by providing clear guidance for license renewal applicants and the NRC staff in preparing and reviewing license renewal applications. The GALL report systematically catalogs aging effects on structures and components; identifies the relevant existing plant programs; and evaluates the existing programs against the attributes considered necessary for an aging management program to be acceptable for license renewal. The GALL report also provides guidance for the augmentation of existing plant programs for license renewal. The revised SRP-LR allows an applicant to reference the GALL report to preclude further NRC staff evaluation if the plant's existing programs meet the criteria described in the GALL report. During the review process, the NRC staff will focus primarily on existing programs that should be augmented or new programs developed specifically for license renewal. The Regulatory Guide is expected to endorse the Nuclear Energy Institute (NEI) guideline, NEI 95-10, Revision 2, entitled 'Industry Guideline for Implementing the Requirements of 10 CFR Part 54 - The License Renewal Rule', which provides guidance for preparing a license renewal application. This paper will provide an introduction to the GALL report, SRP-LR, Regulatory Guide, and NEI 95-10 to show how these documents are interrelated and how they will be used to streamline the license renewal review process. This topic will be of interest to domestic power utilities considering license renewal and international ICONE participants seeking state-of-the-art information about license renewal in the United States

  20. 76 FR 31307 - Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively

    Science.gov (United States)

    2011-05-31

    ... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY: The... Army. The US Army Edgewood Chemical Biological Center and the US Army Research Laboratory intend to...

  1. 76 FR 17840 - Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively

    Science.gov (United States)

    2011-03-31

    ... DEPARTMENT OF DEFENSE Department of the Army Notice of Intent To License Government-Owned Inventions; Intent To License Exclusively AGENCY: Department of the Army, DoD. ACTION: Notice. SUMMARY: The... McGill telephone: 410-436-8467, [email protected]us.army.mil , U.S. Army Edgewood Chemical Biological Center...

  2. 75 FR 15743 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-03-30

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the...-Enriched 160.0 kilograms To fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149...

  3. 75 FR 6223 - Application For a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-08

    ... NUCLEAR REGULATORY COMMISSION Application For a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the..., Uranium (93.35%). uranium (16.3 targets for December 28, 2009, XSNM3623, kilograms U-235). irradiation in...

  4. 77 FR 1956 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-01-12

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(b) ``Public Notice of Receipt of an Application,'' please take notice that the.... Security Complex. Uranium uranium (9.3 targets at December 21, 2011 (93.35%). kilograms U- CERCA AREVA...

  5. 75 FR 7525 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-19

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public notice of receipt of an application,'' please take notice that the..., February 2, Uranium (93.35%). uranium (87.3 elements in 2010, February 2, 2010, kilograms U-235). France...

  6. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1993-01-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes

  7. 77 FR 6552 - Mahoning Hydropower, LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-02-08

    ... Hydropower, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and...: December 7, 2011. d. Submitted By: Mahoning Hydropower, LLC. e. Name of Project: Berlin Lake Hydroelectric... Hydropower, LLC, 11365 Normandy Lane, Chagrin Falls, OH 44023; (440) 804-6627; [email protected] i. FERC...

  8. Preparing to review the license application of the French geological disposal facility - Issues, challenges and perspectives

    International Nuclear Information System (INIS)

    Dandrieux, Geraldine

    2014-01-01

    This paper briefly describes the French context for GDR authorization, the French dedicated legislative framework (28 June 2006 Act on sustainable management of radioactive materials and waste), the challenges (regulatory issues, long-term project supervision, technical issues, procedural issues), and the preparing for the review of the DGR license application. A planning schedule is propose with Andra to submit license application for DGR in 2015

  9. Information to be submitted in support of licensing applications for nuclear power plants

    International Nuclear Information System (INIS)

    1979-01-01

    This Safety Guide was prepared as part of the Agency's programme, referred to as the NUSS programme, for establishing Codes of Practice and Safety Guides relating to nuclear power plants. It supplements the Agency's Safety Series No.50-C-G, entitled ''Governmental Organization for the Regulation of Nuclear Power Plants: A Code of Practice''. It is concerned with the content of documents which should be submitted to the regulatory body by the applicant/licensee in support of licensing applications, with a possible method of classifying these documents and with the scheduling of their submission to the regulatory body at each major stage of the licensing process

  10. 77 FR 21592 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2012-04-10

    ... Licensing of Non-Power Reactors: Format and Content,'' for the production of radioisotopes and NUREG-1537, Part 2, ``Guidelines for Preparing and Reviewing Applications for the Licensing of Non-Power Reactors... by searching on http://www.regulations.gov under Docket ID NRC-2011-0135. You may submit comments by...

  11. 78 FR 45578 - Application For a License to Export Radioactive Waste

    Science.gov (United States)

    2013-07-29

    ... NUCLEAR REGULATORY COMMISSION Application For a License to Export Radioactive Waste Pursuant to 10..., 2013, radioactive waste authorized for disposal by the XW021, 11006101. as contaminated export will not original secondary waste exceed quantities generators, as resulting from imported in required or the...

  12. 76 FR 52994 - Application for a License To Export Heavy Water

    Science.gov (United States)

    2011-08-24

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export Heavy Water Pursuant to 10 CFR... (liters). producing an active water). pharmaceutical ingredient known as CTP-499, which incorporates heavy water as the source of deuterium to achieve the hydrogen-deuterium exchange. November 30, 2010 December...

  13. 77 FR 34030 - BOST1 Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application...

    Science.gov (United States)

    2012-06-08

    ... Hydroelectric LLC; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Date Filed: March 21, 2012. d. Submitted By: BOST1 Hydroelectric LLC (BOST1). e. Name of Project: Coon Rapids Dam Hydroelectric Project. f. Location: Mississippi River in Hennepin and Anoka counties...

  14. Do US Medical Licensing Applications Treat Mental and Physical Illness Equivalently?

    Science.gov (United States)

    Gold, Katherine J; Shih, Elizabeth R; Goldman, Edward B; Schwenk, Thomas L

    2017-06-01

    State medical licensing boards are responsible for evaluating physician impairment. Given the stigma generated by mental health issues among physicians and in the medical training culture, we were interested in whether states asked about mental and physical health conditions differently and whether questions focused on current impairment. Two authors reviewed physician medical licensing applications for US physicians seeking first-time licensing in 2013 in the 50 states and the District of Columbia. Questions about physical and mental health, as well as substance abuse, were identified and coded as to whether or not they asked about diagnosis and/or treatment or limited the questions to conditions causing physician impairment. Forty-three (84%) states asked questions about mental health conditions, 43 (84%) about physical health conditions, and 47 (92%) about substance use. States were more likely to ask for history of treatment and prior hospitalization for mental health and substance use, compared with physical health disorders. Among states asking about mental health, just 23 (53%) limited all questions to disorders causing functional impairment and just 6 (14%) limited to current problems. While most state medical licensing boards ask about mental health conditions or treatment, only half limited queries to disorders causing impairment. Differences in how state licensing boards assess mental health raise important ethical and legal questions about assessing physician ability to practice and may discourage treatment for physicians who might otherwise benefit from appropriate care.

  15. NUPLEX Licensing Subcommittee

    International Nuclear Information System (INIS)

    Edwards, D.W.; Allen, S.R.

    1988-01-01

    The NUPLEX Licensing Subcommittee was organized to seek a formal license renewal mechanism that institutionalizes the current licensing basis and consequent level of safety of a plant as the legitimate standard for acceptance and approval of an application for extended operation. Along with defining the most workable approach to and scope of review for license renewal, this paper explains the reasons why a regulatory framework is needed by the early 1990s. The initial results of development work on two key issues, licensing criteria and hearing process, are also presented. at this point six potential license renewal criteria have emerged: evaluation of existing monitoring/maintenance programs, revalidation of current licensing basis, conformance to special regulations, evaluation to a safety goal, plant performance history, and environmental assessment. The work on a hearing process has led to the development of two models for future consideration: hybrid legislative and hybrid adjudicatory

  16. Safety evaluation review of the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1991-08-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the belowground vault (BGV) alternative method of low-level radioactive waste disposal. In Volume 1 of NUREG-1375, the NRC staff provided the safety review results for an earth-mounded concrete bunker PLASAR. In the current report, the staff focused its review on the design, construction, and operational aspects of the BGV PLASAR. The staff developed review comments and questions using the Standard Review Plan (SRP), Rev. 1 (NUREG-1200) as the basis for evaluating the acceptability of the information provided in the BGV PLASAR. The detailed review comments provided in this report are intended to be useful guidance to facility developers and State regulators in addressing issues likely to be encountered in the review of a license application for a low-level-waste disposal facility. 44 refs

  17. [Radiation protection in medical research : Licensing requirement for the use of radiation and advice for the application procedure].

    Science.gov (United States)

    Minkov, V; Klammer, H; Brix, G

    2017-07-01

    In Germany, persons who are to be exposed to radiation for medical research purposes are protected by a licensing requirement. However, there are considerable uncertainties on the part of the applicants as to whether licensing by the competent Federal Office for Radiation Protection is necessary, and regarding the choice of application procedure. The article provides explanatory notes and practical assistance for applicants and an outlook on the forthcoming new regulations concerning the law on radiation protection of persons in the field of medical research. Questions and typical mistakes in the application process were identified and evaluated. The qualified physicians involved in a study are responsible for deciding whether a license is required for the intended application of radiation. The decision can be guided by answering the key question whether the study participants would undergo the same exposures regarding type and extent if they had not taken part in the study. When physicians are still unsure about their decision, they can seek the advisory service provided by the professional medical societies. Certain groups of people are particularly protected through the prohibition or restriction of radiation exposure. A simplified licensing procedure is used for a proportion of diagnostic procedures involving radiation when all related requirements are met; otherwise, the regular licensing procedure should be used. The new radiation protection law, which will enter into force on the 31st of december 2018, provides a notification procedure in addition to deadlines for both the notification and the licensing procedures. In the article, the authors consider how eligible studies involving applications of radiation that are legally not admissible at present may be feasible in the future, while still ensuring a high protection level for study participants.

  18. 18 CFR 131.20 - Application for approval of transfer of license.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Application for approval of transfer of license. 131.20 Section 131.20 Conservation of Power and Water Resources FEDERAL... a citizen of the United States of America. Subscribed and sworn to before me, a notary public of the...

  19. Regulatory systems-based licensing guidance documentation

    International Nuclear Information System (INIS)

    Delligatti, M.S.

    1991-01-01

    The US Nuclear Regulatory Commission (NRC) has developed a series of licensing guidance documents based on the regulatory requirements in Part 60 of Title 10 of the Code of Federal Regulations (10 CFR Part 60). This regulatory systems-based approach to licensing guidance documentation relies on the definition of the high-level waste repository in 10 CFR Part 60. A document which is important for the frame-work it gives to other programmatic licensing guidance is the Draft Regulatory Guide open-quotes Format and Content for the License Application for the High-Level Waste Repositoryclose quotes (FCRG). The FCRG describes a format and content acceptable to NRC for a high-level waste repository license application pursuant to the requirements of 10 CFR Part 60. Other licensing guidance documents will be compatible with the FCRG

  20. 22 CFR 96.30 - State licensing.

    Science.gov (United States)

    2010-04-01

    ... Licensing and Corporate Governance § 96.30 State licensing. (a) The agency or person is properly licensed or... person follows applicable State licensing and regulatory requirements in all jurisdictions in which it provides adoption services. (c) If it provides adoption services in a State in which it is not itself...

  1. LTO License Application Project NPP Borssele

    International Nuclear Information System (INIS)

    Jong, A.E. de; Blom, F.J.; Leilich, J.

    2012-01-01

    Borssele NPP plans to extend its operating life with 20 years until 2034. Borssele has started the project LTO 'bewijsvoering' (LTO 'Justification') in order to meet the requirements of the Dutch regulator. The outline of the project is based on IAEA safety guide 57 'Safe Long Term Operation of Nuclear Power Plants'. This paper describes the contents and coherence of the different parts in the project and how these respond to the IAEA guidelines on LTO. The goal of the project LTO 'bewijsvoering' is to ensure that safety and safety relevant systems, structures and components continue to perform their intended functions during long term operation. The outcome of the project LTO 'bewijsvoering' will be used for a license change application and this will be submitted to the Dutch regulator KFD for approval of prolonged operation of Borssele NPP after 2013. (author)

  2. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    International Nuclear Information System (INIS)

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination

  3. Guidelines for preparing and reviewing applications for the licensing of non-power reactors: Standard review plan and acceptance criteria. NUREG - 1537, Part 2

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-02-01

    NUREG - 1537, Part 2 gives guidance on the conduct of licensing action reviews to NRC staff who review non-power reactor licensing applications. These licensing actions include construction permits and initial operating licenses, license renewals, amendments, conversions from highly enriched uranium to low-enriched uranium, decommissioning, and license termination.

  4. 77 FR 76483 - Ocean Transportation Intermediary License Applicants The Commission gives notice that the...

    Science.gov (United States)

    2012-12-28

    ... Transport Co., PAC International Logistics Company, & Book Express Network. Stealth Logistics LLC (NVO & OFF.... Application Type: QI Change. Efrinsa Global Logistics Inc. (NVO & OFF), 8441 NW 68th Street, Miami, FL 33166... (QI), Sheila E. Lawrence, President. Application Type: New OFF License. MMC Logistics, LLC (OFF), 2853...

  5. Preparing as an organization to review a construction license application for a DGR for HLW and SF in the USA

    International Nuclear Information System (INIS)

    Hill, Brittain

    2014-01-01

    Although formally opposed by the State of Nevada, the Yucca Mountain site (Nevada) recommendation was approved by the U.S. Congress and the President, which authorized DOE to prepare and submit a license application for a deep geologic repository for the nation's spent nuclear fuel and high-level waste. In June of 2008, DOE submitted this application to the U.S. Nuclear Regulatory Commission (NRC) for its review and formal adjudication of contested issues during a 3-4 year period. Although subsequent actions by the Administration and Congress have changed the direction for geologic disposal in the U.S., the NRC staff was able to conduct a thorough technical review of the DOE license application and issue technical evaluation reports before the review and hearings were suspended in September 2011. This paper provides the author's perspective on how the NRC prepared for, and conducted, this first-of-a-kind licensing review: planning framework, key preparations for staff and for processes, events after the receipt of a license application, retrospective on staff preparations and on processes. By the end of September 2011, the NRC staff had issued three Technical Evaluation Reports using a risk-informed, performance-based approach to review the DOE license application for this deep geologic repository at Yucca Mountain

  6. 78 FR 33448 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2013-06-04

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Security Complex, May 13, Uranium (93.35%). uranium-235 at the National 2013, May 21, 2013, XSNM3745, contained in 7.5 Research Universal 11006098. kilograms reactor in Canada for uranium. ultimate use in...

  7. 77 FR 12830 - Pershing County Water Conservation District; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2012-03-02

    ... Water Conservation District; Notice of Intent To File License Application, Filing of Pre-Application.... Submitted by: Pershing County Water Conservation District (Pershing County). e. Name of Project: Humboldt... the Commission's regulations. h. Potential Applicant Contact: Bennie Hodges, Pershing County Water...

  8. Use of annotated outlines to prepare guidance for license applications for the MRS and MGDS

    International Nuclear Information System (INIS)

    Roberts, J.; Griffin, W.R.

    1992-01-01

    This paper reports that the Office of Civilian Radioactive Waste Management (OCRWM) has embarked on an aggressive program to develop guidance for preparation of the License Applications for the Mined Geological Disposal System (MGDS) and Monitored Retrievable Storage (MRS). The endeavor is a team effort that will utilize personnel and funding from the Office of Systems and Compliance at DOE Headquarters, the MRS Project (i.e., DOE Office of Storage and Transportation) and the Yucca Mountain Project (i.e., DOE Office of Geologic Disposal). The endeavor was initiated in the Spring of 1991. It will continue via an iterative process until License Applications are completed for the MRS and MGDS projects

  9. 77 FR 73056 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant... Complex. Uranium (93.2%). uranium-235 at CERCA AREVA Romans October 10, 2012 contained in 6.2 in France and to October 12, 2012 kilograms irradiate targets at XSNM3729 uranium. the BR-2 Research 11006053...

  10. 77 FR 73055 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-12-07

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Security Complex. Uranium uranium-235 at CERCA AREVA October 10, 2012 (93.35%). contained in Romans in France October 12, 2012 10.1 kilograms and to irradiate XSNM3730 uranium. targets at the HFR 11006054...

  11. 77 FR 51579 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2012-08-24

    ... NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant.... Complex, July 30, 2012, August Uranium (93.35%). uranium-235 high-enriched 1, 2012, XSNM3726, 11006037. contained in 7.5 uranium in the kilograms uranium. form of broken metal to the Atomic Energy of Canada...

  12. 77 FR 74841 - Alabama Power Company; Notice of Application for Amendment of License and Soliciting Comments...

    Science.gov (United States)

    2012-12-18

    ... patrons who access the restaurant by boat. l. Locations of the Application: A copy of the application is... Company; Notice of Application for Amendment of License and Soliciting Comments, Motions To Intervene, and Protests Take notice that the following hydroelectric application has been filed with the Commission and is...

  13. The United States nuclear regulatory commission license renewal process

    International Nuclear Information System (INIS)

    Holian, B.E.

    2009-01-01

    The United States (U.S.) Nuclear Regulatory Commission (NRC) license renewal process establishes the technical and administrative requirements for the renewal of operating power plant licenses. Reactor ope-rating licenses were originally issued for 40 years and are allowed to be renewed. The review process for license renewal applications (L.R.A.) provides continued assurance that the level of safety provided by an applicant's current licensing basis is maintained for the period of extended operation. The license renewal review focuses on passive, long-lived structures and components of the plant that are subject to the effects of aging. The applicant must demonstrate that programs are in place to manage those aging effects. The review also verifies that analyses based on the current operating term have been evaluated and shown to be valid for the period of extended operation. The NRC has renewed the licenses for 52 reactors at 30 plant sites. Each applicant requested, and was granted, an extension of 20 years. Applications to renew the licenses of 20 additional reactors at 13 plant sites are under review. As license renewal is voluntary, the decision to seek license renewal and the timing of the application is made by the licensee. However, the NRC expects that, over time, essentially all U.S. operating reactors will request license renewal. In 2009, the U.S. has 4 plants that enter their 41. year of ope-ration. The U.S. Nuclear Industry has expressed interest in 'life beyond 60', that is, requesting approval of a second renewal period. U.S. regulations allow for subsequent license renewals. The NRC is working with the U.S. Department of Energy (DOE) on research related to light water reactor sustainability. (author)

  14. Relations between intuitive biological thinking and biological misconceptions in biology majors and nonmajors.

    Science.gov (United States)

    Coley, John D; Tanner, Kimberly

    2015-03-02

    Research and theory development in cognitive psychology and science education research remain largely isolated. Biology education researchers have documented persistent scientifically inaccurate ideas, often termed misconceptions, among biology students across biological domains. In parallel, cognitive and developmental psychologists have described intuitive conceptual systems--teleological, essentialist, and anthropocentric thinking--that humans use to reason about biology. We hypothesize that seemingly unrelated biological misconceptions may have common origins in these intuitive ways of knowing, termed cognitive construals. We presented 137 undergraduate biology majors and nonmajors with six biological misconceptions. They indicated their agreement with each statement, and explained their rationale for their response. Results indicate frequent agreement with misconceptions, and frequent use of construal-based reasoning among both biology majors and nonmajors in their written explanations. Moreover, results also show associations between specific construals and the misconceptions hypothesized to arise from those construals. Strikingly, such associations were stronger among biology majors than nonmajors. These results demonstrate important linkages between intuitive ways of thinking and misconceptions in discipline-based reasoning, and raise questions about the origins, persistence, and generality of relations between intuitive reasoning and biological misconceptions. © 2015 J. D. Coley and K. Tanner. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  15. 75 FR 71102 - White Mountain Hydroelectric Corp.; Notice of Application for Amendment of License, and...

    Science.gov (United States)

    2010-11-22

    ... Hydroelectric Corp.; Notice of Application for Amendment of License, and Soliciting Comments, Motions To Intervene, and Protests November 12, 2010. Take notice that the following hydroelectric application has been... Hydroelectric Corp. e. Name of Project: Apthorp Hydroelectric Project. f. Location: The project is located on...

  16. Operator licensing examiner standards

    International Nuclear Information System (INIS)

    1994-06-01

    The Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining licensees and applicants for reactor operator and senior reactor operator licenses at power reactor facilities pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). The Examiner Standards are intended to assist NRC examiners and facility licensees to better understand the initial and requalification examination processes and to ensure the equitable and consistent administration of examinations to all applicants. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator licensing policy changes. Revision 7 was published in January 1993 and became effective in August 1993. Supplement 1 is being issued primarily to implement administrative changes to the requalification examination program resulting from the amendment to 10 CFR 55 that eliminated the requirement for every licensed operator to pass an NRC-conducted requalification examination as a condition for license renewal. The supplement does not substantially alter either the initial or requalification examination processes and will become effective 30 days after its publication is noticed in the Federal Register. The corporate notification letters issued after the effective date will provide facility licensees with at least 90 days notice that the examinations will be administered in accordance with the revised procedures

  17. Licensing issues

    International Nuclear Information System (INIS)

    Roberts, J.P.; Desell, L.J.; Birch, M.L.; Berkowitz, L.; Bader, J.F.

    1992-01-01

    To provide guidance for the Department of Energy's (DOE) Civilian Radioactive Waste Management Program, the Nuclear Regulatory Commission (NRC) has issued a draft regulatory guide on the Format and Content for the License Application for the High-Level Waste Repository (FCRG). To facilitate the development of the FCRG, NRC suggested that DOE use the draft guide as the basis for preparing an annotated outline for a license application. DOE is doing so using an iterative process called the Annotated Outline Initiative. DOE;s use of the Initiative will assist in achieving the desired incorporation of actual experience in the FCRG, contribute to the development of shared interpretation and understanding of NRC regulations, and provide other important programmatic benefits described in this paper

  18. DOE Patents Available for Licensing

    International Nuclear Information System (INIS)

    Stuber, C.

    1981-01-01

    DOE Patents Available for Licensing (DOE PAL) provides abstracting and indexing coverage of the DOE patent literature, including patent applications, that concerns any apsect of energy production, conservation, and utilization. The citations are arranged by subject category. DOE is prepared to grant exclusive or nonexclusive, revocable licenses under DOE-owned US patents and patent applications in accordance with the provisions of 10CFR781

  19. NUMARC view of license renewal criteria

    International Nuclear Information System (INIS)

    Edwards, D.W.

    1989-01-01

    The Atomic Energy Act and the implementing regulations of the US Nuclear Regulatory Commission (NRC) permit the renewal of nuclear plant operating licenses upon expiration of their 40-year license term. However, the regulatory process by which license renewal may be accomplished and the requirements for the scope and content of renewal applications are yet to be established. On August 29, 1988, the NRC published an Advanced Notice of Proposed Rulemaking regarding the subject of license renewal. This Advanced Notice and the NUREG which it references, NUREG-1317, Regulatory Options for Nuclear Plant License Renewal, provide the most recent regulatory thought on this issue. The basic issue addressed by NUREG-1317 is the definition of an adequate licensing basis for the renewal of a plant license. The report contemplates three alternatives in this regard. This paper discusses each of these three proposals. The NUMARC NUPLEX Working Group endorses a license renewal process based on a plant's current licensing basis along with an evaluation of the pertinent components, systems, and structures affected by age-related degradation. The NUMARC NUPLEX Working group believes that an appropriate scope for NRC review of the license renewal application should focus on those safety-significant structures systems, and components subject to significant age-related degradation that are not subject to existing recognized effective replacement, refurbishment, or inspection programs. The paper also briefly discusses NUMARC's view of the role of the Backfit Rule in the license renewal process

  20. License renewal in the United States

    International Nuclear Information System (INIS)

    Brons, Jack

    2002-01-01

    Full text: Nuclear plants in the United States are licensed for 40 years, a length specified in the Atomic Energy Act of 1954, which laid out much of the regulatory basis for the commercial nuclear industry. The Act, however, made provision for license renewal. The original 40-year license period was chosen arbitrarily by the U.S. Congress because it was the typical period over which utilities recovered their investment in electricity generating plants. Nuclear plants, however, are subject to a rigorous program of Nuclear Regulatory Commission oversight, maintenance and equipment replacement. In effect, they must be in the same operating condition on the last day of their licenses as they were on the first. As the industry matured, it became apparent that there was no physical limitation on the continued operation of nuclear plants past 40 years. The industry turned its attention toward license renewal. When the issue was first raised, the NRC considered stringent process equivalent to seeking a new operating license for each plant. The complexity, length and cost of the process made it unlikely that many nuclear plants would seek license renewal. The nuclear industry worked successfully with NRC on the application of generic principles to license renewal, however, and in 1995, the NRC issued an efficient, tightly-focused rule that made license renewal a safe, viable option. To extend the operating license for a reactor, a company must demonstrate to the NRC that aging effects will be adequately managed during the renewal terms, thus ensuring equipment functionality. The rule allows licensees to apply for extensions of up to 20 years. The first license renewal application was filed in 1998 by the owner of the two-unit Calvert Cliffs plant. Shortly thereafter, an application was filed for the three-unit Oconee Nuclear Station. The NRC renewed the licenses for all five units in 2000, and since then, five more licenses have been renewed. The NRC has received 37

  1. Screening Analysis of Criticality Features, Events, and Processes for License Application

    International Nuclear Information System (INIS)

    J.A. McClure

    2004-01-01

    This report documents the screening analysis of postclosure criticality features, events, and processes. It addresses the probability of criticality events resulting from degradation processes as well as disruptive events (i.e., seismic, rock fall, and igneous). Probability evaluations are performed utilizing the configuration generator described in ''Configuration Generator Model'', a component of the methodology from ''Disposal Criticality Analysis Methodology Topical Report''. The total probability per package of criticality is compared against the regulatory probability criterion for inclusion of events established in 10 CFR 63.114(d) (consider only events that have at least one chance in 10,000 of occurring over 10,000 years). The total probability of criticality accounts for the evaluation of identified potential critical configurations of all baselined commercial and U.S. Department of Energy spent nuclear fuel waste form and waste package combinations, both internal and external to the waste packages. This criticality screening analysis utilizes available information for the 21-Pressurized Water Reactor Absorber Plate, 12-Pressurized Water Reactor Absorber Plate, 44-Boiling Water Reactor Absorber Plate, 24-Boiling Water Reactor Absorber Plate, and the 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Short waste package types. Where defensible, assumptions have been made for the evaluation of the following waste package types in order to perform a complete criticality screening analysis: 21-Pressurized Water Reactor Control Rod, 5-Defense High-Level Radioactive Waste/U.S. Department of Energy Long, and 2-Multi-Canister Overpack/2-Defense High-Level Radioactive Waste package types. The inputs used to establish probabilities for this analysis report are based on information and data generated for the Total System Performance Assessment for the License Application, where available. This analysis report determines whether criticality is to be

  2. The Monticello license renewal project

    International Nuclear Information System (INIS)

    Clauss, J.M.; Harrison, D.L.; Pickens, T.A.

    1993-01-01

    Today, 111 nuclear power plants provide over 20 percent of the electrical energy generated in the United States. The operating license of the oldest operating plant will expire in 2003, one-third of the existing operating licenses will expire by 2010 and the newest plant's operating license will expire in 2033. The National Energy Strategy (NES) prepared by the Department of Energy (DOE) assumes that 70 percent of the current operating plants will continue to operate beyond their current license expiration. Power from current operating plants can assist in ensuring an adequate, diverse, and environmentally acceptable energy supply for economic growth and improved U.S. competitiveness. In order to preserve this energy resource, three major tasks must be successfully completed: (1) establishment of regulations, technical standards, and procedures for the preparation and review of License Renewal Applications (LRAs); (2) development of technical criteria and bases for monitoring, refurbishing or replacing plant equipment; and (3) demonstration of the regulatory process by a plant obtaining a renewed license. Since 1986, the DOE has been working with the nuclear industry and the Nuclear Regulatory Commission (NRC) to establish and demonstrate the option to extend the life of a nuclear power plant by renewing the operating license. The Monticello Lead Plant demonstration project was initiated in September 1988, following the Pilot Plant studies. This paper is primarily focused on the status and insights gained from the Northern States Power Company (NSP) Monticello Lead Plant demonstration project. The following information is included: (1) Current Status - Monticello License Renewal Application; (2) Economic Analysis; (3) License Renewal Regulatory Uncertainty Issues; (4) Key Decisions; (5) Management Structure; (6) Technical and Licensing Perspective; (7) NRC Interactions; (8) Summary

  3. Shirley Basin Uranium Mill. Environmental report to accompany source material license application

    International Nuclear Information System (INIS)

    1975-12-01

    This document summarizes all of the environmental monitoring conducted by Utah. This Environmental Report consequently supplements and updates the information presented in the Source Material License application of August 18, 1970 and the Final Environmental Statement (FES) of December 1974. Water and air quality, liquid waste management, soil/vegetation monitoring, and reclamation are covered

  4. Licensing and advanced fuel designs

    International Nuclear Information System (INIS)

    Davidson, S.L.; Novendstern, E.H.

    1991-01-01

    For the past 15 years, Westinghouse has been actively involved in the development and licensing of fuel designs that contain major advanced features. These designs include the optimized fuel assembly, The VANTAGE 5 fuel assembly, the VANTAGE 5H, and most recently the VANTAGE+ fuel assembly. Each of these designs was supported by extensive experimental data, safety evaluations, and design efforts and required intensive interaction with the US Nuclear Regulatory Commission (NRC) during the review and approval process. This paper presents a description of the licensing approach and how it was utilized by the utilities to facilitate the licensing applications of the advanced fuel designs for their plants. The licensing approach described in this paper has been successfully applied to four major advanced fuel design changes ∼40 plant-specific applications, and >350 cycle-specific reloads in the past 15 years

  5. Facilities license application record data as of April 1, 1981. Tri-annual report 30 Nov 80-1 Apr 81

    International Nuclear Information System (INIS)

    1981-06-01

    The FLAR is divided into three parts as follows: Part I - The first part is a listing of all operating licenses, authorizations and construction permits in effect plus applications pending; Part II - The second part is a listing of applications that have been withdrawn or denied, and licenses and construction permits terminated or revoked; and Part III - The third part is a listing of research, test and power reactors for export

  6. Nuclear plant license renewal

    International Nuclear Information System (INIS)

    Gazda, P.A.; Bhatt, P.C.

    1991-01-01

    During the next 10 years, nuclear plant license renewal is expected to become a significant issue. Recent Electric Power Research Institute (EPRI) studies have shown license renewal to be technically and economically feasible. Filing an application for license renewal with the Nuclear Regulatory Commission (NRC) entails verifying that the systems, structures, and components essential for safety will continue to perform their safety functions throughout the license renewal period. This paper discusses the current proposed requirements for this verification and the current industry knowledge regarding age-related degradation of structures. Elements of a license renewal program incorporating NRC requirements and industry knowledge including a schedule are presented. Degradation mechanisms for structural components, their significance to nuclear plant structures, and industry-suggested age-related degradation management options are also reviewed

  7. 76 FR 4417 - Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application

    Science.gov (United States)

    2011-01-25

    ... DEPARTMENT OF TRANSPORTATION Maritime Administration [USCG-2010-0993] Liberty Natural Gas LLC, Liberty Liquefied Natural Gas (LNG) Deepwater Port License Application AGENCY: Maritime Administration... application describes an offshore natural gas deepwater port facility that would be located approximately 16.2...

  8. 75 FR 3261 - Powertech (USA) Inc.; Dewey-Burdock Project; New Source Material License Application; Notice of...

    Science.gov (United States)

    2010-01-20

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 40-9075; NRC-2009-0575] Powertech (USA) Inc.; Dewey... review process related to the Dewey- Burdock Uranium Project application, please contact the NRC... documents associated with the Dewey-Burdock Uranium Project, including the license application, are...

  9. Perspective about the US license Renewal for NNPP's

    International Nuclear Information System (INIS)

    Lehnert, D. F.

    2004-01-01

    This article provides and overview of the US License Renewal Rule, 10 CFR 54, and its implementation in the US leading to the preparation and review of a license renewal application. The key regulatory documents and the industry's methodology and guidance for successfully implementing the Rule are discussed. While the process still undergoes change and optimization, it has become predictable and reliable, such that utilities can establish realistic schedules and budgets to complete the license renewal process. Nearly 60% of the US operating units have either received and extended operating license, have submitted their application for review, or have committed to submit an application in the next few years. The article concludes with a discussion of lessons learned from this wealth of experience and some emerging issues that may affect license renewal process. (Author)

  10. 75 FR 69080 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2010-11-10

    ... license as a Non-Vessel-Operating Common Carrier (NVO), and/or Ocean Freight Forwarder (OFF)--Ocean..., Building 14-A, Kenner, LA 70062, Officers: Gary J. Cheramie, President (Qualifying Individual), George...: License Transfer. Total Global Solutions, Inc. (NVO & OFF), 4290 Bells Ferry Road 224, Suite 106, Kennesaw...

  11. Non-Power Reactor Operator Licensing Examiner Standards

    International Nuclear Information System (INIS)

    1994-06-01

    The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR Part 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, this standard will be revised periodically to accommodate comments and reflect new information or experience

  12. 78 FR 32650 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-05-31

    ... Change Abaco Logistics Corporation (OFF), 8051 NW 67th Street, Miami, FL 33166, Officers: Manuel T. Soto...: New NVO & OFF License Star Cluster Logistics (NVO & OFF), 4 Executive Circle, Suite 170, Irvine, CA... License Straight Forwarding, Inc. (NVO & OFF), 20974 Currier Road, City of Industry, CA 91789, Officer: Yi...

  13. Licensing of away-from-reactor (AFR) installations

    International Nuclear Information System (INIS)

    Gray, P.L.

    1980-01-01

    Storage of spent fuel at Away-From-Reactor (AFR) installations will allow reactors to continue to operate until reprocessing or other fuel disposal means are available. AFR installations must be licensed by the Nuclear Regulatory Commission (NRC). Although wide experience in licensing reactors exists, the licensing of an AFR installation is a relatively new activity. Only one has been licensed to date. This paper delineates the requirements for licensing an AFR installation and projects a licensing schedule. Because the NRC is developing specific AFR requirements, this schedule is based primarily on draft NRC documents. The major documents needed for an AFR license application are similar to those for a reactor. They include: a Safety Analysis Report (SAR), and Environmental Report (ER), safeguards and security plans, decommissioning plans, proposed technical specifications, and others. However, the licensing effort has one major difference in that for AFR installations it will be a one-step effort, with follow-up, rather than the two-step process used for reactors. The projected licensing schedule shows that the elapsed time between filing an application and issuance of a license will be about 32 months, assuming intervention. The legal procedural steps will determine the time schedule and will override considerations of technical complexity. A license could be issued in about 14 months in the absence of intervention

  14. Dry spent fuel storage licensing

    International Nuclear Information System (INIS)

    Sturz, F.C.

    1995-01-01

    In the US, at-reactor-site dry spent fuel storage in independent spent fuel storage installations (ISFSI) has become the principal option for utilities needing storage capacity outside of the reactor spent fuel pools. Delays in the geologic repository operational date at or beyond 2010, and the increasing uncertainty of the US Department of Energy's (DOE) being able to site and license a Monitored Retrievable Storage (MRS) facility by 1998 make at-reactor-site dry storage of spent nuclear fuel increasingly desirable to utilities and DOE to meet the need for additional spent fuel storage capacity until disposal, in a repository, is available. The past year has been another busy year for dry spent fuel storage licensing. The licensing staff has been reviewing 7 applications and 12 amendment requests, as well as participating in inspection-related activities. The authors have licensed, on a site-specific basis, a variety of dry technologies (cask, module, and vault). By using certified designs, site-specific licensing is no longer required. Another new cask has been certified. They have received one new application for cask certification and two amendments to a certified cask design. As they stand on the brink of receiving multiple applications from DOE for the MPC, they are preparing to meet the needs of this national program. With the range of technical and licensing options available to utilities, the authors believe that utilities can meet their need for additional spent fuel storage capacity for essentially all reactor sites through the next decade

  15. 78 FR 40519 - Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving...

    Science.gov (United States)

    2013-07-05

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-298; NRC-2013-0139] Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving Proposed No Significant Hazards..., issued to Nebraska Public Power District (the licensee), for operation of the Cooper Nuclear Station (CNS...

  16. Guide for the preparation of applications for licenses for the use of self-contained dry source-storage irradiators. Second proposed Revision 1

    International Nuclear Information System (INIS)

    Bassin, N.

    1984-10-01

    The purpose of this regulatory guide is to provide assistance to applicants and licensees in preparing applications for new licenses, license amendments, and license renewals for the use of self-contained dry source-storage irradiators. These irradiators are constructed so that the sealed sources and the material being irradiated are contained in a shielded volume and there is no external radiation beam during the use of the irradiator. The radioisotopes most commonly used for these irradiators are cobalt-60 and cesium-137

  17. Licensing process in Finland

    International Nuclear Information System (INIS)

    Tiippana, Petteri

    2011-01-01

    In accordance with the Nuclear Energy Act, the use of nuclear energy constitutes operations subject to license. The licensing process and conditions for granting a license is defined in the legislation. The licenses are applied from and granted by the Government. This paper discusses briefly the licensing process in Finland and also the roles and responsibilities of main stakeholders in licensing. Licensing of a nuclear power plant in Finland has three steps. The first step is the Decision in Principle (DiP). Goal of DiP is to decide whether using nuclear power is for the overall good for the Finnish society. The second step is Construction License (CL) and the goal of CL phase is to determine whether the design of the proposed plant is safe and that the participating organisations are capable of constructing the plant to meet safety goals. The third step is the Operating License (OL) and the goal of the OL phase is to determine whether the plant operates safely and licensee is capable to operate the plant safely. Main stakeholders in the licensing process in Finland are the utility (licensee) interested in using nuclear power in Finland, Ministry of Employment and the Economy (MEE), Government, Parliament, STUK, the municipality siting the plant and the general public. Government grants all licenses, and Parliament has to ratify Government's Decision in Principle. STUK has to assess the safety of the license applications in each step and give statement to the Ministry. Municipality has to agree to site the plant. Both STUK and the municipality have a veto right in the licensing process

  18. Licensing of New Nuclear Power Plants in Canada

    International Nuclear Information System (INIS)

    Schwarz, Garry; Miller, Doug

    2011-01-01

    The regulatory process for new power plant licensing in Canada, from receipt of the initial application to commercial operation, can be divided into three phases: - Environmental Assessment (EA) and License to Prepare Site; - License to Construct; and - License to Operate. The Nuclear Safety and Control Act (NSCA) does not have provisions for combined licenses for site preparation, construction, or operation. Separate licenses must, therefore, be granted for each phase, and would be issued in sequence. However, applications to prepare a site, to construct and to operate a new nuclear power plant could be assessed in parallel. The total duration from the application for the License to Prepare Site to the issuance of the License to Operate (which is a prerequisite for first fuel load) has been established as 9 years subject to certain factors. To help facilitate this timeline, the CNSC has undertaken an aggressive program of documenting regulatory practices, requirements and guidance to assist applicants in submitting complete applications. Working level procedures to assist CNSC staff in their review of submissions are also under development. Extensive program and project management has been introduced to ensure that timelines will be achieved. In parallel with the above activities, regulatory oversight measures to be employed during site preparation activities and plant construction and commissioning are also being developed. On the international front, the CNSC is participating in the MDEP program to leverage the resources and knowledge of other national regulatory authorities in reviews the CNSC is undertaking. The CNSC also participates in IAEA and other international activities to utilize/adapt international practices as appropriate in Canada. (authors)

  19. 18 CFR 16.10 - Information to be provided by an applicant for new license: Filing requirements.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL POWER ACT PROCEDURES RELATING TO TAKEOVER AND RELICENSING OF LICENSED PROJECTS Applications for... redistribution of power flows on line loading (with respect to applicable thermal, voltage, or stability limits... governmental agencies and subdivisions likely to be interested in or affected by the proposed expansion. (11...

  20. 47 CFR 25.137 - Application requirements for earth stations operating with non-U.S. licensed space stations.

    Science.gov (United States)

    2010-10-01

    ... space stations. (a) Earth station applicants or entities filing a “letter of intent” or “Petition for... Union. (d) Earth station applicants requesting authority to operate with a non-U.S.-licensed space... 47 Telecommunication 2 2010-10-01 2010-10-01 false Application requirements for earth stations...

  1. Challenges of SMR licensing practices

    Energy Technology Data Exchange (ETDEWEB)

    Soderholm, K., E-mail: kristiina.soderholm@fortum.com [Fortum Power, Espoo (Finland)

    2012-12-15

    This paper aims to increase the understanding of high level Nuclear Power Plant (NPP) licensing processes in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their different licensing processes and recent actions in new NPP construction. After discussing their similarities and differences, suitable features for Small Modular Reactor licensing can be emphasized and suggested. Some of the studied licensing processes have elements that are already quite well suited for application to SMRs, but all of these different national processes can benefit from studying and implementing lessons learned from SMR specific licensing needs. The main SMR features to take into account in licensing are standardization of the design, modularity, mass production and serial construction. Modularity can be divided into two different categories: the first category is simply a single unit facility constructed of independently engineered modules (e.g., construction process for Westinghouse AP-1000 NPP) and the second is a facility structure composed of many reactor modules where modules are manufactured in factories and installed into the facility as needed (e.g., NuScale Power SMR design). Short construction schedules will not be fully benefited from if the long licensing process prolongs the commissioning and approach to full-power operation. The focus area of this study is to better understand the possibility of SMR deployment in small nuclear countries, such as Finland, which currently has four operating NPPs. The licensing process needs to be simple and clear to make SMR deployment feasible from an economical point of view. This paper uses public information and interviews with experts to establish the overview of the different licensing processes and their main steps. A high-level comparison of the licensing steps has been carried out. Certain aspects of the aviation industry licensing process have also been studied and certain

  2. Nuclear Regulatory Commission staff development of the license application review plan for a high-level radioactive waste repository

    International Nuclear Information System (INIS)

    Johnson, R.L.; Holonich, J.J.; Lee, M.P.; Delligatti, M.S.

    1993-01-01

    The Nuclear Regulatory Commission staff has recently started a new initiative to develop the License Application Review Plan (LARP) which the staff will use in its reviews of the U.S. Department of Energy's (DOE's) license application (LA) for a geologic repository for the disposal of high-level radioactive waste (HLW). This paper describes the staff's approach for developing the LARP, the development schedule and current status, the organization and content of the LARP, and the staff's LA review strategy. Therefore, it gives a preview of the draft LARP which will be made available in late 1993. It also describes how the LARP will be used as guidance to the staff in conducting reviews of regulatory and technical issues important to the licensing of a geologic repository. Finally, the benefits to the NRC staff, DOE, and other parties are discussed

  3. 47 CFR 25.117 - Modification of station license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Modification of station license. 25.117 Section 25.117 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses General Application Filing Requirements § 25.117...

  4. Strategic Basis for License Application Planning for a Potential Yucca Mountain Repository

    International Nuclear Information System (INIS)

    Newberry, C. M.; Brocoum, S. J.; Gamble, R. P.; Murray, R. C.; Cline, M.

    2002-01-01

    If Yucca Mountain, Nevada is designated as the site for development of a geologic repository for disposal of spent nuclear fuel and high-level radioactive waste, the Department of Energy (DOE) must obtain Nuclear Regulatory Commission (NRC) approval first for repository construction, then for an operating license, and, eventually, for repository closure and decommissioning. The licensing criteria defined in Code of Federal Regulations, Title 10, Part 63 (10 CFR Part 63) establish the basis for these NRC decisions. Submittal of a license application (LA) to the NRC for authorization to construct a repository at the Yucca Mountain site is, at this point, only a potential future action by the DOE. The policy process defined in the Nuclear Waste Policy Act (NWPA), as amended, for recommendation and designation of Yucca Mountain as a repository site makes it difficult to predict whether or when the site might be designated. The DOE may only submit a LA to the NRC if the site designation takes effect. In spite of this uncertainty, the DOE must take prudent and appropriate action now, and over the next several years, to prepare for development and timely submittal of a LA. This is particularly true given the need for the DOE to develop, load, and certify the operation of its electronic information system to provide access to its relevant records as part of the licensing support network (LSN) in compliance with NRC requirements six months prior to LA submittal. The DOE must also develop a LA, which is a substantially different document from those developed to support a Site Recommendation (SR) decision. The LA must satisfy NRC licensing criteria and content requirements, and address the acceptance criteria defined by the NRC in its forthcoming Yucca Mountain Review Plan (YMRP). The content of the LA must be adequate to facilitate NRC acceptance and docketing for review, and the LA and its supporting documents must provide the documented basis for the NR C findings required

  5. 9 CFR 2.6 - Annual license fees.

    Science.gov (United States)

    2010-01-01

    ... method used to calculate the license fee. All initial license and changed class of license fees must be... research facilities, dealers, exhibitors, retail pet stores, and persons for use as pets, directly or through an auction sale, by the dealer or applicant during his or her preceding business year (calendar or...

  6. Integration of MGDS design into the licensing process

    International Nuclear Information System (INIS)

    1997-12-01

    This paper presents an overview of how the Mined Geologic Disposal System (MGDS) design for a potential repository is integrated into the licensing process. The integration process employs a two-told approach: (1) ensure that the MGDS design complies with applicable Nuclear Regulatory Commission (NRC) licensing requirements, and (2) ensure that the MGDS design is appropriately reflected in a license application that is acceptable to the NRC for performing acceptance and compliance reviews

  7. License Application Design Selection Report, REV 01. August 1999

    International Nuclear Information System (INIS)

    Hastings, C.R.

    1999-01-01

    In December 1998, the U.S. Department of Energy (DOE) published the ''Viability Assessment of a Repository at Yucca Mountain'' (DOE 1998b). The Viability Assessment described a preliminary design of a potential repository at Yucca Mountain, Nevada, for disposal of spent nuclear fuel and high-level radioactive waste, and assessed the probable behavior of that repository design in the Yucca Mountain geologic setting. The report concluded that 'Yucca Mountain remains a promising site for a geologic repository and that work should proceed to support a decision in 2001 on whether to recommend the site to the President for development as a repository'. It also concluded that 'uncertainties remain about key natural processes, the preliminary design, and how the site and design would interact'. Recognizing that the design that was evaluated will be refined before a license application could be submitted, the Viability Aassesment notes that 'DOE is evaluating several design options and alternatives that could reduce existing uncertainty and improve the performance of the repository system'. During the preparation of the Viability Assessment, DOE asked the contractor for the Civilian Radioactive Waste Management Program to study alternative design concepts for a potential geologic repository for high-level radioactive waste at Yucca Mountain. The License Application Design Selection (LADS) project was initiated to conduct that study. The goal of the project was to develop and evaluate a diverse range of conceptual repository designs that work well in concert with the Yucca Mountain site and to recommend an initial design concept for the possible Site Recommendation and License Apllication. This report presents the results of the LADS project. The design process consisted of two phases. In Phase I, a series of basic design concepts (design alternatives) and components (design features) were analyzed for their potential value as elements of a repository design. In Phase II

  8. Application of neutrons in biology

    International Nuclear Information System (INIS)

    Cser, L.

    1982-01-01

    Applications of neutron scattering to determine the structure of biological macromolecules are reviewed. A theoretical and experimental introduction to neutron scattering and its mathematical description is given. The analysis of crystal structure using neutron scattering and the problem of Fourier reconstruction of structure are discussed. Some special problems concerning biological materials are described. The isotope effect of neutron scattering is applied to determine and identify the hydrogen atoms in biological macromolecules. Some examples illustrating the structure determination of amino acids and proteins are given. Mathematical methods of evaluation of small angle neutron scattering experiments and applications to investigate E. coli ribosome are described. New developments and new research trends are also reviewed. (D.Gy.)

  9. Consolidated guidance about materials licenses: Program-specific guidance about portable gauge licenses. Final report; Volume 1

    Energy Technology Data Exchange (ETDEWEB)

    Vacca, P.C.; Whitten, J.E.; Pelchat, J.M.; Arredondo, S.A.; Matson, E.R.; Lewis, S.H.; Collins, D.J.; Santiago, P.A. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Industrial and Medical Nuclear Safety; Tingle, W. [Dept. of Environment, Health, and Natural Resources, Raleigh, NC (United States). Div. of Radiation Protection

    1997-05-01

    As part of its redesign of the materials licensing process, NRC is consolidating and updating numerous guidance documents into a single comprehensive repository as described in NUREG-1539 and draft NUREG-1541. NUREG-1556, Vol. 1, is the first program-specific guidance developed for the new process and will serve as a template for subsequent program-specific guidance. This document is intended for use by applicants, licensees, and NRC staff and will also be available to Agreement States. This document supersedes the guidance previously found in draft Regulatory Guide DG-0008, ``Applications for the Use of Sealed Sources in Portable Gauging Devices,`` and in NMSs Policy and guidance Directive 2-07, ``Standard Review Plan for Applications for Use of Sealed Sources in Portable Gauging Devices.`` This final report takes a more risk-informed, performance-based approach to licensing portable gauges, and reduces the information(amount and level of detail) needed to support an application to use these devices. It incorporates many suggests submitted during the comment period on draft NUREG-1556, Volume 1. When published, this final report should be used in preparing portable gauge license applications. NRC staff will use this final report in reviewing these applications.

  10. Consolidated guidance about materials licenses: Program-specific guidance about portable gauge licenses. Final report; Volume 1

    International Nuclear Information System (INIS)

    Vacca, P.C.; Whitten, J.E.; Pelchat, J.M.; Arredondo, S.A.; Matson, E.R.; Lewis, S.H.; Collins, D.J.; Santiago, P.A.; Tingle, W.

    1997-05-01

    As part of its redesign of the materials licensing process, NRC is consolidating and updating numerous guidance documents into a single comprehensive repository as described in NUREG-1539 and draft NUREG-1541. NUREG-1556, Vol. 1, is the first program-specific guidance developed for the new process and will serve as a template for subsequent program-specific guidance. This document is intended for use by applicants, licensees, and NRC staff and will also be available to Agreement States. This document supersedes the guidance previously found in draft Regulatory Guide DG-0008, ''Applications for the Use of Sealed Sources in Portable Gauging Devices,'' and in NMSs Policy and guidance Directive 2-07, ''Standard Review Plan for Applications for Use of Sealed Sources in Portable Gauging Devices.'' This final report takes a more risk-informed, performance-based approach to licensing portable gauges, and reduces the information(amount and level of detail) needed to support an application to use these devices. It incorporates many suggests submitted during the comment period on draft NUREG-1556, Volume 1. When published, this final report should be used in preparing portable gauge license applications. NRC staff will use this final report in reviewing these applications

  11. List of Nuclear Materials Licensing Actions Received

    Data.gov (United States)

    Nuclear Regulatory Commission — A catalog of all Materials Licensing Actions received for review. The catalog lists the name of the entity submitting the license application, their city and state,...

  12. 75 FR 4571 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2010-01-28

    .... Applications: Therapies for tumors associated with NF1 (including brain and peripheral nervous system tumors...-US-01). Licensing Status: Available for licensing. Licensing Contact: Patrick P. McCue, Ph.D.; 301...

  13. 10 CFR 34.13 - Specific license for industrial radiography.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Specific license for industrial radiography. 34.13 Section 34.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY... industrial radiography. An application for a specific license for the use of licensed material in industrial...

  14. NEP Nuclear Power Plant, Units 1 and 2. License application, general and financial information

    International Nuclear Information System (INIS)

    1976-01-01

    A license application is presented for 2 pressurized water reactors at a proposed location in Charlestown RI. Each reactor will have a net capacity of 1150 MW. Cooling water will be supplied by the Atlantic Ocean. NEP-1 is scheduled for operation in 1983 and NEP-2 in 1985

  15. Review process for low-level radioactive waste disposal license application under Low-Level Radioactive Waste Policy Amendments Act

    International Nuclear Information System (INIS)

    Pittiglio, C.L. Jr.

    1987-08-01

    This document estimates the level of effort and expertise that is needed to review a license application within the required time. It is intended to be used by the NRC staff as well as States and interested parties to provide a better understanding of what the NRC envisions will be involved in licensing a low-level radioactive waste disposal facility. 5 refs., 3 figs., 1 tab

  16. Palo Verde Generating Station, Units 4 and 5. License application, general information

    International Nuclear Information System (INIS)

    1978-01-01

    A license application for two more Palo Verde reactors, Units 4 and 5, is presented. The two PWR reactors have a nominal net generating power each of 1,270 MW(e). Containments are steel-lined prestressed cylindrical structures with hemispherical domes. The reactors are replicas of Palo Verde 1, 2 and 3 (see DOCKETS 50528, 50529 and 50530) using the standard Combustion Engineering System 80 (see DOCKET-STN-50470)

  17. 76 FR 63668 - Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes

    Science.gov (United States)

    2011-10-13

    ..., Research and Test Reactors Projects Branch, Division of Policy and Rulemaking, Office of Nuclear Reactor... NUCLEAR REGULATORY COMMISSION [NRC-2011-0135] Guidelines for Preparing and Reviewing Licensing Applications for the Production of Radioisotopes AGENCY: Nuclear Regulatory Commission. ACTION: Draft interim...

  18. 76 FR 71082 - Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License Application...

    Science.gov (United States)

    2011-11-16

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 40-9091; NRC-2011-0148] Strata Energy, Inc., Ross Uranium Recovery Project; New Source Material License Application; Notice of Intent To Prepare a... intent to prepare a supplemental environmental impact statement. SUMMARY: Strata Energy, Inc. (Strata...

  19. Gibbs and Hill Standard Safety Analysis Report, GIBBSSAR. License application, volume 1: chapters 1--3 (section 7)

    International Nuclear Information System (INIS)

    1977-01-01

    License application for the GIBBSSAR Standard Plant is presented. The reactor used with the GIBBSSAR balance-of-plant system is the Westinghouse 3800 MW(t) PWR. This portion of the application includes a general plant description; site characteristics; and design of structures, components, equipment and systems

  20. License Application Design Selection Feature Report: Aging and Blending

    International Nuclear Information System (INIS)

    Coltoni, B.; Anderson, M.J.

    1999-01-01

    The purpose of this document is to evaluate the concepts of Aging and Blending for waste sent to the Monitored Geologic Repository (MGR). These design features are based on pre-emplacement treatment of the waste stream. The envelope of the analysis has been performed under the direction of the License Application Design Selection Team (LADST), which advocated utilizing the Viability Assessment (VA) repository design (DOE 1998c) as the basis. Therefore, this evaluation attempts to modify the VA design only to the extent that Aging and Blending can be accomplished. This modified VA design will be contrasted to the VA Design and the difference in design, costs, and performance will be presented

  1. Regulatory guidance for license renewal

    International Nuclear Information System (INIS)

    Thoma, John A.

    1991-01-01

    The proposed 10 CFR Part 54 rule proceduralizes the process for license renewal by identifying both the administrative and technical requirements for a renewal application. To amplify and support this regulation, written guidance has been provided in the form of a draft Regulatory Guide (DG 1009) and a draft Standard Review Plan for License Renewal (NUREG 1299). This guidance is scheduled to be finalized in 1992. Similar guidance will be provided for the proposed revisions to 10 CFR Part 51 concerning the environmental aspects of license renewal. (author)

  2. NPP License Renewal and Aging Management: Revised Guidance

    International Nuclear Information System (INIS)

    Hull, A.B.; Hiser, A.L.; Lindo-Talin, S.E.

    2012-01-01

    Based on the Atomic Energy Act, the NRC issues licenses for commercial power reactors to operate for up to 40 years and allows these licenses to be renewed for up to another 20 years. NRC has approved license renewal for well over 50% of U.S. located reactors originally licensed to operate for 40 years. Of these 104 reactors (69 PWRs, 35 BWRs), the NRC has issued renewed licenses for 71 units and is currently reviewing applications for another 15 units. As of May 1, 2012, ten plants at nine sites had entered their 41st year of operation and thus are in their first period of extended operation (PEO). Five more plants will enter the PEO by the end of 2012. One foundation of the license renewal process has been license renewal guidance documents (LRGDs). The U.S. Nuclear Regulatory Commission (NRC) revised key guidance documents used for nuclear power license renewal in 2010 and 2011. These include NUREG-1800, 'Standard Review Plan for Review of License Renewal Applications,' revision 2 (SRP-LR), and NUREG-1801, 'Generic Aging Lessons Learned (GALL) Report,' revision 2 (GALL Report). The guidance documents were updated to reflect lessons learned and operating experience gained since the guidance documents were last issued in 2005. (author)

  3. 75 FR 54330 - Intent To Grant an Exclusive Field of Use License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-09-07

    ... DEPARTMENT OF DEFENSE Department of the Army Intent To Grant an Exclusive Field of Use License of a U.S. Government-Owned Patent Application AGENCY: Department of the Army, DoD. ACTION: Notice... intent to grant an exclusive, revocable license for the field of use in the research reagent market to...

  4. 75 FR 39668 - Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application

    Science.gov (United States)

    2010-07-12

    ... DEPARTMENT OF DEFENSE Department of the Army Intent To Grant a Field of Use Exclusive License of a U.S. Government-Owned Patent Application AGENCY: Department of the Army, DoD. ACTION: Notice... intent to grant a field of use exclusive, revocable license for the field of shigella vaccine development...

  5. Guide to request license for teletherapy practice

    International Nuclear Information System (INIS)

    2000-01-01

    In this work the steps to request license for teletherapy practice are described , among these steps they it continued it plows to request the qualified personnel's yams, the operation authorization, application purpose, license type

  6. Current status of the PBMR licensing project

    International Nuclear Information System (INIS)

    Mysen, A.; Clapisson, G.A.; Metcalf, P.E.

    2000-01-01

    The CNS is currently reviewing the PBMR conceptual design from a licensibility point of view. The PBMR concept is based on a High Temperature Gas Cooled Reactor - pebble bed reactor type. It is anticipated that the PBMR design will rely on inherent safety characteristics to contain fission products within fuel over the full range of design basis events. This feature combined with the high temperature integrity of the fuel and structural graphite, allows the safe use of a high coolant temperature, which allows consideration of the future development of this reactor for non-electrical applications of nuclear heat for industrial use. The CNS licensing approach requires that the licensing and design basis of the plant should respect prevailing international norms and practices and that a quantitative risk assessment should demonstrate compliance with the CNS fundamental safety standards. The first stage of the licensing process is now ongoing; this is a pre-application phase, which will result in a statement on licensibility being issued. Identification of the specific documentation requirements and information needed is required across every step of the licensing process. Top level regulatory requirements have been established for the PBMR. They include the CNS fundamental safety standard and basic licensing criteria, which describes requirements on licensees of nuclear installations regarding risk assessment and compliance with the safety criteria and define classification of licensing basis events. (author)

  7. USNRC licensing process as related to nuclear criticality safety

    International Nuclear Information System (INIS)

    Ketzlach, N.

    1987-01-01

    The U.S. Code of Federal Regulations establishes procedures and criteria for the issuance of licenses to receive title to, own, acquire, deliver, receive, possess, use, and initially transfer special nuclear material; and establishes and provides for the terms and conditions upon which the Nuclear Regulatory Commission (NRC) will issue such licenses. Section 70.22 of the regulations, ''Contents of Applications'', requires that applications for licenses contain proposed procedures to avoid accidental conditions of criticality. These procedures are elements of a nuclear criticality safety program for operations with fissionable materials at fuels and materials facilities (i.e., fuel cycle facilities other than nuclear reactors) in which there exists a potential for criticality accidents. To assist the applicant in providing specific information needed for a nuclear criticality safety program in a license application, the NRC has issued regulatory guides. The NRC requirements for nuclear criticality safety include organizational, administrative, and technical requirements. For purely technical matters on nuclear criticality safety these guides endorse national standards. Others provide guidance on the standard format and content of license applications, guidance on evaluating radiological consequences of criticality accidents, or guidance for dealing with other radiation safety issues. (author)

  8. 76 FR 40905 - Turnagain Arm Tidal Electric Energy Project; Notice of Intent To File License Application, Filing...

    Science.gov (United States)

    2011-07-12

    ... Tidal Electric Energy Project; Notice of Intent To File License Application, Filing of Pre-Application....: 13509-001. c. Dated Filed: May 11, 2011. d. Submitted By: Turnagain Arm Tidal Energy Corporation. e. Name of Project: Turnagain Arm Tidal Electric Energy Project. f. Location: Of the Upper Cook Inlet off...

  9. 77 FR 58370 - Pennamaquan Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-09-20

    ... Tidal Power LLC; Notice of Intent To File License Application, Filing of Pre-Application Document (PAD... Filed: July 19, 2012. d. Submitted By: Pennamaquan Tidal Power LLC (Pennamaquan Power). e. Name of Project: Pennamaquan Tidal Power Plant Project. f. Location: On the Pennamaquan River at the entrance to...

  10. 78 FR 29393 - University of Missouri-Columbia Facility Operating License No. R-103

    Science.gov (United States)

    2013-05-20

    ... Facility Operating License No. R-103 AGENCY: Nuclear Regulatory Commission. ACTION: License renewal... the renewal of Facility Operating License No. R-103 (``Application''), which currently authorizes the... application for the renewal of Facility Operating License No. R-103, which, currently authorizes the licensee...

  11. 47 CFR 25.113 - Station licenses and launch authority.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Station licenses and launch authority. 25.113 Section 25.113 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses General Application Filing Requirements § 25.113 Station...

  12. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    International Nuclear Information System (INIS)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z.

    2015-01-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  13. Application of probabilistic risk assessment in nuclear and environmental licensing processes of nuclear reactors in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Mata, Jonatas F.C. da; Vasconcelos, Vanderley de; Mesquita, Amir Z., E-mail: jonatasfmata@yahoo.com.br, E-mail: vasconv@cdtn.br, E-mail: amir@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)

    2015-07-01

    The nuclear accident at Fukushima Daiichi, occurred in Japan in 2011, brought reflections, worldwide, on the management of nuclear and environmental licensing processes of existing nuclear reactors. One of the key lessons learned in this matter, is that the studies of Probabilistic Safety Assessment and Severe Accidents are becoming essential, even in the early stage of a nuclear development project. In Brazil, Brazilian Nuclear Energy Commission, CNEN, conducts the nuclear licensing. The organism responsible for the environmental licensing is Brazilian Institute of Environment and Renewable Natural Resources, IBAMA. In the scope of the licensing processes of these two institutions, the safety analysis is essentially deterministic, complemented by probabilistic studies. The Probabilistic Safety Assessment (PSA) is the study performed to evaluate the behavior of the nuclear reactor in a sequence of events that may lead to the melting of its core. It includes both probability and consequence estimation of these events, which are called Severe Accidents, allowing to obtain the risk assessment of the plant. Thus, the possible shortcomings in the design of systems are identified, providing basis for safety assessment and improving safety. During the environmental licensing, a Quantitative Risk Analysis (QRA), including probabilistic evaluations, is required in order to support the development of the Risk Analysis Study, the Risk Management Program and the Emergency Plan. This article aims to provide an overview of probabilistic risk assessment methodologies and their applications in nuclear and environmental licensing processes of nuclear reactors in Brazil. (author)

  14. TMI-related requirements for new operating licenses. Technical report

    International Nuclear Information System (INIS)

    1980-06-01

    There are four types of TMI-related requirements and actions approved by the Commission for new operating licenses: (1) those required to be completed by a license applicant prior to receiving a fuel-loading and low-power testing license, (2) those required to be completed by a license applicant prior to receiving a license to operate at appreciable power levels up to full power, (3) those the NRC will take prior to issuing a fuel-loading and low-power testing or a full-power operating license, and (4) those required to be completed by a licensee prior to a specified date. In this report, only those dated requirements that have already been issued are of interest. Other dated requirements are expected to be issued in the future as work progresses in accordance with the TMI Action Plan. This report summarizes the several parts of the list of TMI-related requirements approved by the Commission for new operating licenses

  15. 76 FR 81992 - PPL Bell Bend, LLC; Combined License Application for Bell Bend Nuclear Power Plant; Exemption

    Science.gov (United States)

    2011-12-29

    ... License Application for Bell Bend Nuclear Power Plant; Exemption 1.0 Background PPL Bell Bend, LLC... for Nuclear Power Plants.'' This reactor is to be identified as Bell Bend Nuclear Power Plant (BBNPP... based upon the U.S. EPR reference COL (RCOL) application for UniStar's Calvert Cliffs Nuclear Power...

  16. Non-Power Reactor Operator Licensing Examiner Standards. Revision 1

    International Nuclear Information System (INIS)

    1995-06-01

    The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience

  17. Non-Power Reactor Operator Licensing Examiner Standards. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Non-Power Reactor Operator Licensing Examiner Standards provide policy and guidance to NRC examiners and establish the procedures and practices for examining and licensing of applicants for NRC operator licenses pursuant to Part 55 of Title 10 of the Code of Federal Regulations (10 CFR 55). They are intended to assist NRC examiners and facility licensees to understand the examination process better and to provide for equitable and consistent administration of examinations to all applicants by NRC examiners. These standards are not a substitute for the operator licensing regulations and are subject to revision or other internal operator examination licensing policy changes. As appropriate, these standards will be revised periodically to accommodate comments and reflect new information or experience.

  18. 78 FR 64493 - Juneau Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA) and Draft...

    Science.gov (United States)

    2013-10-29

    ... Hydropower, Inc.; Notice of Subsequent Draft License Application (DLA) and Draft Preliminary Draft... Hydropower, Inc. e. Name of Project: Sweetheart Lake Hydroelectric Project. f. Location: At the confluence of..., Business Manager, Juneau Hydropower, Inc., P.O. Box 22775, Juneau, AK 99802; 907-789-2775, email: duff...

  19. 76 FR 53693 - Notice of Invitation To Participate; Coal Exploration License Application COC-74911, Colorado

    Science.gov (United States)

    2011-08-29

    ...] Notice of Invitation To Participate; Coal Exploration License Application COC-74911, Colorado AGENCY: Bureau of Land Management, Interior. ACTION: Notice. SUMMARY: Pursuant to the Mineral Leasing Act of 1920... America in lands located in Delta County, Colorado. DATES: This notice of invitation was published in the...

  20. 15 CFR 732.4 - Steps regarding License Exceptions.

    Science.gov (United States)

    2010-01-01

    ... General Prohibition Six (Embargo), consult part 746 of the EAR for applicable License Exceptions. (b... export or reexport is subject to General Prohibition Six (Embargo) for embargoed destinations, License...

  1. 48 CFR 1852.227-86 - Commercial computer software-Licensing.

    Science.gov (United States)

    2010-10-01

    .../contractor proposes its standard commercial software license, those applicable portions thereof consistent... its standard commercial software license until after this purchase order/contract has been issued, or at or after the time the computer software is delivered, such license shall nevertheless be deemed...

  2. Synthetic biology: programming cells for biomedical applications.

    Science.gov (United States)

    Hörner, Maximilian; Reischmann, Nadine; Weber, Wilfried

    2012-01-01

    The emerging field of synthetic biology is a novel biological discipline at the interface between traditional biology, chemistry, and engineering sciences. Synthetic biology aims at the rational design of complex synthetic biological devices and systems with desired properties by combining compatible, modular biological parts in a systematic manner. While the first engineered systems were mainly proof-of-principle studies to demonstrate the power of the modular engineering approach of synthetic biology, subsequent systems focus on applications in the health, environmental, and energy sectors. This review describes recent approaches for biomedical applications that were developed along the synthetic biology design hierarchy, at the level of individual parts, of devices, and of complex multicellular systems. It describes how synthetic biological parts can be used for the synthesis of drug-delivery tools, how synthetic biological devices can facilitate the discovery of novel drugs, and how multicellular synthetic ecosystems can give insight into population dynamics of parasites and hosts. These examples demonstrate how this new discipline could contribute to novel solutions in the biopharmaceutical industry.

  3. Biological applications of the Moessbauer effect

    International Nuclear Information System (INIS)

    Boulay, P.

    1968-12-01

    The applications of Moessbauer spectrometry in the fields of physics and chemistry have been increasing steadily since its discovery in 1958. Attempts have been made to find applications in biology. Two possibilities of investigation exist in this field: the study of mechanical or vibrational movements in certain animal organs, and the determination of the organic molecular structure in a biological context. An example is given of each of these possibilities. (author) [fr

  4. Validation and Application of the Survey of Teaching Beliefs and Practices for Undergraduates (STEP-U): Identifying Factors Associated with Valuing Important Workplace Skills among Biology Students.

    Science.gov (United States)

    Marbach-Ad, Gili; Rietschel, Carly; Thompson, Katerina V

    2016-01-01

    We present a novel assessment tool for measuring biology students' values and experiences across their undergraduate degree program. Our Survey of Teaching Beliefs and Practices for Undergraduates (STEP-U) assesses the extent to which students value skills needed for the workplace (e.g., ability to work in groups) and their experiences with teaching practices purported to promote such skills (e.g., group work). The survey was validated through factor analyses in a large sample of biology seniors (n = 1389) and through response process analyses (five interviewees). The STEP-U skills items were characterized by two underlying factors: retention (e.g., memorization) and transfer (e.g., knowledge application). Multiple linear regression models were used to examine relationships between classroom experiences, values, and student characteristics (e.g., gender, cumulative grade point average [GPA], and research experience). Student demographic and experiential factors predicted the extent to which students valued particular skills. Students with lower GPAs valued retention skills more than those with higher GPAs. Students with research experience placed greater value on scientific writing and interdisciplinary understanding. Greater experience with specific teaching practices was associated with valuing the corresponding skills more highly. The STEP-U can provide feedback vital for designing curricula that better prepare students for their intended postgraduate careers. © 2016 G. Marbach-Ad et al. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  5. The safety case in support of the license application of the surface repository of low-level waste in Dessel, Belgium

    International Nuclear Information System (INIS)

    Wacquier, William; Cool, Wim

    2014-01-01

    The modern concept of the safety case, developed by the OECD/NEA for geological repositories of high- and medium-level waste has been successfully applied by ONDRAF/ NIRAS for a surface repository for Category A waste (i.e. low-level waste) in Belgium in the current project phase 2006-2012. This resulted in the submission on 31 January 2013 by ONDRAF/NIRAS of an application for a 'construction and operation license' to the safety authorities. The benefits of using the notion of the safety case have been that: i) safety has been incorporated in an integrated manner within all assessment basis, design and safety assessment activities; ii) the process of development of the license application has gained in clarity and traceability; iii) the documentation of the license application contains multiple lines of argumentation for safety rather than argumentation based only on quantitative radiological impact calculations. To offer a comprehensive view on the safety argumentation and its development, it has been found useful to develop the argumentation not only along a safety statements structure but also along the safety report structure. (authors)

  6. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    Energy Technology Data Exchange (ETDEWEB)

    R.J. Garrett

    2005-02-17

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified.

  7. INTERNAL HAZARDS ANALYSIS FOR LICENSE APPLICATION

    International Nuclear Information System (INIS)

    Garrett, R.J.

    2005-01-01

    The purpose of this internal hazards analysis is to identify and document the internal hazards and potential initiating events associated with preclosure operations of the repository at Yucca Mountain. Internal hazards are those hazards presented by the operation of the facility and by its associated processes that can potentially lead to a radioactive release or cause a radiological hazard. In contrast to external hazards, internal hazards do not involve natural phenomena and external man-made hazards. This internal hazards analysis was performed in support of the preclosure safety analysis and the License Application for the Yucca Mountain Project. The methodology for this analysis provides a systematic means to identify internal hazards and potential initiating events that may result in a radiological hazard or radiological release during the repository preclosure period. These hazards are documented in tables of potential internal hazards and potential initiating events (Section 6.6) for input to the repository event sequence categorization process. The results of this analysis will undergo further screening and analysis based on the criteria that apply to the performance of event sequence analyses for the repository preclosure period. The evolving design of the repository will be re-evaluated periodically to ensure that internal hazards that have not been previously evaluated are identified

  8. 77 FR 48130 - Prospective Grant of Exclusive Patent License

    Science.gov (United States)

    2012-08-13

    ... Exclusive Patent License AGENCY: National Institute of Standards and Technology, Commerce. ACTION: Notice of prospective grant of exclusive patent license. SUMMARY: This is a notice in accordance with 35 U.S.C. 209(e... Provisional Application for Patent Application No. 61,638,362 titled ``Flow Cytometer Systems and Associated...

  9. Aging management review for license renewal and plant life management

    International Nuclear Information System (INIS)

    Rinckel, M.A.; Young, G.G.

    2002-01-01

    Full text: United States nuclear power plants are initially licensed for a period of 40-years. The 40-year term, which was established by the Atomic Energy Commission in the 1950s, is believed to be based on engineering judgement and is consistent with the typical amortization schedule for purchasing fossil power plants. Under 10 CFR Part 54, the license renewal rule, additional terms of 20-years may be obtained through the preparation of a license renewal application that must be reviewed and approved by the Nuclear Regulatory Commission (NRC). The license renewal rule requires that applicants perform ageing management reviews on passive long-lived structures and components to demonstrate that ageing will be managed during the period of extended operation (i.e., additional 20 years of operation). ageing of active components, which are excluded from 10 CFR Part 54, is accomplished through the Maintenance Rule, 10 CFR Part 65, using performance-based monitoring. The license renewal rule, 10 CFR Part 54, was initially published in 1991. After significant interaction with the nuclear industry from 1991 through 1994, the NRC revised the rule in 1995 to focus on passive long-lived structures and components. In 1998, the first two applications for license renewal were submitted to the NRC by Baltimore Gas and Electric for the two-unit Calvert Cliffs nuclear power plant and by Duke Energy for the three-unit Oconee nuclear power plant. In March 2000, the NRC approved the application for the two-unit Calvert Cliffs nuclear power plant for an additional 20 years. Two months later, the NRC approved the renewal of the operating licenses for the three-unit Oconee nuclear station. The NRC completed these reviews in a timely, predictable, and stable manner. As of February 2002, the NRC has approved renewal of operating licenses for eight nuclear units and has applications under review for 15 more units. Twelve additional companies have notified the NRC of their intention to seek

  10. NPP License Renewal and Aging Management: Revised Guidance

    International Nuclear Information System (INIS)

    Hull, A.B.; Hiser, A.L.; Lindo-Talin, S.E.

    2012-01-01

    Based on the Atomic Energy Act, the NRC issues licenses for commercial power reactors to operate for up to 40 years and allows these licenses to be renewed for up to another 20 years. NRC has approved license renewal (LR) for well over 50% of U.S. located reactors originally licensed to operate for 40 years. Of these 104 reactors (69 PWRs, 35 BWRs), the NRC has issued renewed licenses for 71 units and is currently reviewing applications for another 15 units. As of May 1, 2012, ten plants at nine sites had entered their 41st year of operation and thus are in their first period of extended operation (PEO). Five more plants will enter the PEO by the end of 2012. One foundation of the license renewal process has been license renewal guidance documents (LRGDs). The U.S. Nuclear Regulatory Commission (NRC) revised key guidance documents used for nuclear power LR in 2010 and 2011. These include NUREG-1800, 'Standard Review Plan for Review of License Renewal Applications,' revision 2 (SRP-LR), and NUREG-1801, 'Generic Aging Lessons Learned (GALL) Report,' revision 2 (GALL Report). The guidance documents were updated to reflect lessons learned and operating experience gained since the guidance documents were last issued in 2005. The reactor LRGDs referenced in this poster can all be accessed at http://www.nrc.gov/reactors/operating/licensing/renewal/guidance.html (author)

  11. 77 FR 23241 - Lock+ Hydro Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2012-04-18

    ... Friends Fund XXX, LLC; Notice of Intent To File License Application, Filing of Pre-Application Document.... Date Filed: February 20, 2012. d. Submitted By: Lock+ Hydro Friends Fund XXX, LLC. e. Name of Project... Applicant Contact: Mr. Mark R. Stover, Lock+\\TM\\ Hydro Friends Fund XXX, c/o Hydro Green Energy, LLC, 900...

  12. Overview of the Yucca Mountain Licensing Process

    International Nuclear Information System (INIS)

    M. Wisenburg

    2004-01-01

    This paper presents an overview of the licensing process for a Yucca Mountain repository for high-level radioactive waste and spent nuclear fuel. The paper discusses the steps in the licensing proceeding, the roles of the participants, the licensing and hearing requirements contained in the Code of Federal Regulations. A description of the Nuclear Regulatory Commission (NRC) staff acceptance and compliance reviews of the Department of Energy (DOE) application for a construction authorization and a license to receive and possess high-level radioactive waste and spent nuclear fuel is provided. The paper also includes a detailed description of the hearing process

  13. Class I structures license renewal industry report; revision 1. Final report

    International Nuclear Information System (INIS)

    Deng, D.; Renfro, J.; Statton, J.

    1994-07-01

    The U.S. nuclear power industry, through coordination by the Nuclear Management and Resources Council (NUMARC), and sponsorship by the U.S. Department of Energy (DOE) and the Electric Power Research Institute (EPRI), has evaluated age-related degradation effects for a number of major plant systems, structures, and components, in the license renewal technical Industry Reports (IRs). License renewal applicants may choose to reference these IRs in support of their plant-specific license renewal applications, as an equivalent to the integrated plant assessment provisions of the license renewal rule (10 CFR Part 54). This IR provides the technical basis for license renewal for U.S. nuclear power plant Class I structures, with the IR evaluating which structures are Class I. Seventeen structures are explicitly described and evaluated in this IR. These structures are not necessarily classified as Class I at all plants, therefore the license renewal applicant should consult this IR for correct identification

  14. SIMS applications in biological research

    International Nuclear Information System (INIS)

    Prince, K.E.; Burke, P.T.; Kelly, I.J.

    2000-01-01

    Full text: SIMS has been utilised as a tool for biological research since the early 1970's. SIMS' abilities in isotopic detection with high sensitivity, imaging capabilities at a subcellular level, and the possibility of molecular imaging have been the main areas of interest for biological development. However, whilst hundreds of instruments are available in industrial and university laboratories for semiconductor and materials analysis, only a handful successfully perform biological research. For this reason there is generally a lack of awareness of SIMS by the biological community. Biological SIMS analysis requires a working knowledge of both biology and SIMS. Sample preparation is a critical and time consuming prerequisite for any successful biological SIMS study. In addition, for quantification to be possible a homogeneous, matrix matched standard must be available. Once these difficulties are more widely understood and overcome there will be a greater motivation for the biological community to embrace SIMS as a unique tool in their research. This paper provides an overview of some of the more successful biological SIMS application areas internationally, and summarises the types of biological SIMS requests received by ANSTO

  15. 46 CFR 515.14 - Issuance and use of license.

    Science.gov (United States)

    2010-10-01

    ... will issue a license only in the name of the applicant, whether the applicant is a sole proprietorship, a partnership, or a corporation. A license issued to a sole proprietor doing business under a trade name shall be in the name of the sole proprietor, indicating the trade name under which the licensee...

  16. Safety evaluation status report for the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1989-07-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the earth-mounded concrete bunker (EMCB) alternative method of low-level radioactive waste disposal. The NRC reviewers relied extensively on the Standard Review Plan (SRP), Rev.1 (NUREG-1200), to evaluate the acceptability of the information provided in the EMCB PLASAR. The NRC staff selected certain review areas in the PLASAR for development of safety evaluation report input to provide examples of safety assessments that are necessary as part of a licensing review. Because of the fictitious nature of the assumed disposal site, and the decision to limit the review to essentially first-round review status, the NRC staff report is labeled a ''Safety Evaluation Status Report'' (SESR). Appendix A comprises the NRC review comments and questions on the information that DOE submitted in the PLASAR. The NRC concentrated its review on the design and operations-related portions of the EMCB PLASAR

  17. Hidden Markov processes theory and applications to biology

    CERN Document Server

    Vidyasagar, M

    2014-01-01

    This book explores important aspects of Markov and hidden Markov processes and the applications of these ideas to various problems in computational biology. The book starts from first principles, so that no previous knowledge of probability is necessary. However, the work is rigorous and mathematical, making it useful to engineers and mathematicians, even those not interested in biological applications. A range of exercises is provided, including drills to familiarize the reader with concepts and more advanced problems that require deep thinking about the theory. Biological applications are t

  18. Development of radioactive waste management licensing review assistant

    International Nuclear Information System (INIS)

    Loa, W.W.; Chen, S.; Yu, W.C.; Peng, C.M.; Huang, C.L.; Lin, C.

    1992-01-01

    Regulations on radioactive waste disposal are now in urgent need due to our increasing consumption of electric power from nuclear origin. It is set forth that actually applying the regulations to evaluate the license application of new repositories for interim storage and final disposal fo High-Level Waste and Low-Level Waste before the year of 2000. In the mean time, it is expected to establish the basis for the decision on issuing the license. The license review procedure can be very complicated because too many factors must be taken into consideration. However, to maintain a more efficient, accurate, and systematic review procedure, and at the same time to reduce costs, the Artificial Intelligence (AI) techniques may be used. An expert system is designed as a radioactive waste management licensing review aid for the staff those are in charge of the license application. Tasks such as completeness checking, functional areas of review distribution, participation confirmation, knowledge acquisition, review comment collection, weighting calculation, and degree of satisfaction are considered. In this paper the authors will discuss the development of the radioactive waste management licensing review assistant

  19. Nuclear relevant installations licensing methodology in the Argentine Republic

    International Nuclear Information System (INIS)

    Paganini, C.E.

    1986-01-01

    A review of the requeriments of the Nuclear Installations Advisory Committee on Licensing (CALIN) from the nuclear security point of view, is presented. The methodology applied by the CALIN for the licensing in the Argentine Republic is included as well as codes, standards of applications and the interaction between the licensing Authority and the Responsible Entity during the whole process. Finally, the Atucha II nuclear power plant's licensing, in construction at present, is explained and the standard, of the licensing schedule, is presented graphically. (author) [es

  20. Licensing safety critical software

    International Nuclear Information System (INIS)

    Archinoff, G.H.; Brown, R.A.

    1990-01-01

    Licensing difficulties with the shutdown system software at the Darlington Nuclear Generating Station contributed to delays in starting up the station. Even though the station has now been given approval by the Atomic Energy Control Board (AECB) to operate, the software issue has not disappeared - Ontario Hydro has been instructed by the AECB to redesign the software. This article attempts to explain why software based shutdown systems were chosen for Darlington, why there was so much difficulty licensing them, and what the implications are for other safety related software based applications

  1. The U.S. Nuclear Regulatory Commission's antitrust review of nuclear power plants: the conditioning of licenses

    International Nuclear Information System (INIS)

    Penn, D.W.; Delaney, J.B.; Honeycutt, T.C.

    1976-04-01

    The 1970 amendments to Section 105 of the Atomic Energy Act require the Nuclear Regulatory Commission to conduct a prelicensing antitrust review of applications for licenses to construct and operate nuclear power plants. The Commission must make a finding as to whether the granting of a license 'would create or maintain a situation inconsistent with the antitrust laws,' and it has the authority to issue or continue a license, to refuse to issue a license, to rescind or amend a license, and to issue a license with conditions that it deems appropriate. This report provides information about the antitrust license conditions that have resulted from the NRC's antitrust review process. The process itself is described and a catalog of the applications requiring antitrust license conditions is presented. For each application, the license conditions are put into the general categories of unit access, transmission services, coordination, and contractual provisions. For completeness, the report also catalogs applications requiring no antitrust license conditions, and lists applications that were exempted from the 1970 amendments, are the subject of litigation, or have been withdrawn

  2. May compact storage facilities be licensed

    International Nuclear Information System (INIS)

    Gleim, A.; Winter, G.

    1980-01-01

    The authors examine as potential statements fo fact for licensing so-called compact storage facilities for spent fuel elements Sec. 6 to 9c of the German Atomic Energy Act and Sec. 4 of the German Radiation Protection Ordinance. They find that none of these provisions were applicable to compact stroage facilities. In particular, the storage of spent fuel elements was no storage of nuclear fuels licensable under Sec. 6 of the Atomic Energy Act, because Sec. 6 did not cover spent fuel elements. Also in the other wording of the Atomic Energy Act there was no provision, which could be used as a statement of fact for licensing compact storage facilities. Such facilities could not be licensed and, for that reason, were not permitted. (IVR) [de

  3. Standard format and content for the physical protection section of a license application (for facilities other than nuclear power plants)

    International Nuclear Information System (INIS)

    1976-06-01

    The document presented has been prepared as an aid to uniformity and completeness in the preparation and review of the physical protection section of license applications. It is applicable to fuel reprocessing plants, fuel manufacturing plants, SNM tranportation, or other special nuclear material operations involving the possession and use of uranium 235 (contained in uranium enriched to 20 percent or more in the U-235 isotope), uranium 233, or plutonium alone or in any combination in a quantity of 5000 grams or more computed by the formula: grams = (grams contained U-235) + 2.5 (grams U-233 + grams plutonium). The document is not intended to be used for nuclear power plants. The information specified is the minimum needed for a license application. Additional information may be required for completion of the staff review of a particular application

  4. Standard format and content of license applications for plutonium processing and fuel fabrication plants

    International Nuclear Information System (INIS)

    1976-01-01

    The standard format suggested for use in applications for licenses to possess and use special nuclear materials in Pu processing and fuel fabrication plants is presented. It covers general description of the plant, summary safety assessment, site characteristics, principal design criteria, plant design, process systems, waste confinement and management, radiation protection, accident safety analysis, conduct of operations, operating controls and limits, and quality assurance

  5. NRC licensing requirements: DOD options

    International Nuclear Information System (INIS)

    Pike, W.J.; O'Reilly, P.D.

    1982-09-01

    This report describes the licensing process (both safety and environmental) that would apply if the Department of Defense (DOD) chooses to obtain licenses from the US Nuclear Regulatory Commission (NRC) for using nuclear energy for power and luminous sources. The specific nuclear energy sources being considered include: small or medium-size nuclear power reactors; radioisotopic thermoelectric generators with 90 Sr or 238 Pu; radioisotopic dynamic electric generators with 90 Sr or 238 Pu; and applications of radioisotopes for luminous sources (lights) with 3 H, 85 Kr, or 147 Pm. The steps of the licensing process are summarized in the following sections, with particular attention given to the schedule and level of effort necessary to support the process

  6. 75 FR 51451 - Erie Boulevard Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre...

    Science.gov (United States)

    2010-08-20

    ... Hydropower, L.P.; Notice of Intent To File License Application, Filing of Pre-Application Document, and.... Project No.: 7320-040. c. Dated Filed: June 29, 2010. d. Submitted By: Erie Boulevard Hydropower, L.P. e...: John Mudre at (202) 502-8902; or e-mail at [email protected] . j. Erie Boulevard Hydropower, L.P...

  7. 45 CFR 1321.75 - Licenses and safety.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Licenses and safety. 1321.75 Section 1321.75... AND COMMUNITY PROGRAMS ON AGING Service Requirements § 1321.75 Licenses and safety. The State shall... that the facility complies with all applicable State and local health, fire, safety, building, zoning...

  8. 76 FR 57720 - Intent To Grant an Exclusive Patent License

    Science.gov (United States)

    2011-09-16

    ... DEPARTMENT OF DEFENSE Department of the Air Force Intent To Grant an Exclusive Patent License... in: U.S. Patent Application No. 12/932,341, filed on February 23, 2011, entitled ``Resin-Based... INFORMATION CONTACT: An exclusive license for the invention described in this patent application will be...

  9. 75 FR 467 - Notice of Opportunity for Hearing, License Application Request of Powertech (USA) Inc. Dewey...

    Science.gov (United States)

    2010-01-05

    ... Hearing, License Application Request of Powertech (USA) Inc. Dewey-Burdock In Situ Uranium Recovery... Regulatory Commission (NRC) for the Dewey-Burdock In Situ Recovery Facility in Fall River and Custer Counties, South Dakota. The Dewey-Burdock facility would involve the recovery of uranium by in situ recovery (ISR...

  10. NUCLEAR SAFETY DESIGN BASES FOR LICENSE APPLICATION

    International Nuclear Information System (INIS)

    Garrett, R.J.

    2005-01-01

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111 [DIRS 156605] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113 [DIRS 156605] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period

  11. Development of radioactive waste management licensing review assistant

    International Nuclear Information System (INIS)

    Wei-Whua Loa; Suan Chen; Wei-Chu Yu

    1992-01-01

    Regulations on radioactive waste disposal are now in urgent need due to our increasing consumption of electric power from nuclear origin. It is set forth that actually applying the regulations to evaluate the license application of new repositories for interim storage and final disposal of High-Level Waste and Low-Level Waste before the year of 2000. In the mean time, it is expected to establish the basis for the decision on issuing the license. The license review procedure can be very complicated, because too many factors must be taken into consideration. For the time being, licensing review is as much an art as it is a science. The authority usually faces three major problems; (1) the availability of domain expert, (2) maintaining of high quality and consistent reviews, and (3) the documentation of the review process. However, to maintain a more efficient, accurate, and systematic review procedure, and at the same time to reduce costs, the Artificial Intelligence (AI) techniques may be used. An expert system is designed as a radioactive waste management licensing review aid for the staff those are in charge of the license application. Tasks such as completeness checking, functional areas of review distribution, participation confirmation, knowledge acquisition, review comment collection, weighting calculation, and degree of satisfaction are considered. In this paper we will discuss the development of the radioactive waste management licensing review assistant

  12. Total System Performance Assessment-License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2002-09-13

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issue (KTI) agreements, the ''Yucca Mountain Review Plan'' (CNWRA 2002 [158449]), and 10 CFR Part 63. This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are utilized in this document.

  13. AP1000R licensing and deployment in the United States

    International Nuclear Information System (INIS)

    Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L.

    2012-01-01

    In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing actions directed

  14. Development, assessment, licensing, and application of RELAP5YA at Yankee Atomic Electric Company

    International Nuclear Information System (INIS)

    Husain, A.

    1984-01-01

    Since 1975, Yankee Atomic Electric Company (YAEC) has been licensed to perform LOCA analyses (large and small breaks) for PWRs. The methods are based upon the WREM package, comprised of RELAP4-MOD 3, RELAP4-FLOOD, and TOODEE-2EM. Significant efforts were expended to compare WREM models against Appendix K criteria, and to incorporate changes for compliance with the criteria and for improved representation of LOCA phenomena. /SUP 2,3,4/ This internalized capability has been used extensively for licensing the Yankee and Maine Yankee plants, and for timely resolution of LOCA issues which frequently arose. The value of this internalized analysis capability was well recognized by the Yankee management. In 1979, Yankee embarked upon another LOCA Methods Development Program. One objective was to remove extra conservatisms inherent in older codes to provide additional operational flexibility for our plants. Also, we needed a code which could be used in a production mode to provide realistic response for off-normal conditions to be used in operator training and emergency guideline assessment. This program resulted in the development of RELAP5YA. The development, assessment, licensing, and application of RELAP5YA at YAEC is briefly described in this paper

  15. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Science.gov (United States)

    2013-03-06

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11169-029] Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower...

  16. 78 FR 30914 - Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting...

    Science.gov (United States)

    2013-05-23

    .... Description of Request: Grand River Dam Authority (GRDA) requests a temporary variance, for the year 2013, to... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 1494-416] Grand River Dam Authority Notice of Application for Temporary Variance of License and Soliciting Comments, Motions To...

  17. Application of nanotechnology in biology and promising application in radiobiology

    International Nuclear Information System (INIS)

    Zhao Sanhu; Ni Jin; Cai Jianming

    2011-01-01

    As one of the 21-Century high and new technologies, nanotechnology (NT) has been widely applied in all aspects of biology. From now on, it has been used for detecting substance, carrying drug, antibacterial and tumour therapy by its photometric characteristics, mechanics characteristics, thermal property and other characteristics. Because of the unique advantages of nanoparticles, nanotechnology has great potential in radioprotection. In this article, we introduced the application of nanotechnology in modern biology and the primal problems. Meantime, we explain the prospect of its application in radioprotection. (authors)

  18. Total System Performance Assessment - License Application Methods and Approach

    International Nuclear Information System (INIS)

    McNeish, J.

    2003-01-01

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document

  19. 78 FR 4467 - UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3...

    Science.gov (United States)

    2013-01-22

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy, Combined License Application for Calvert Cliffs Power Plant, Unit 3, Exemption 1.0 Background UniStar Nuclear Energy (UNE), on behalf of Calvert Cliffs Nuclear Project, LLC and UniStar Nuclear Operating Services...

  20. 76 FR 81994 - UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit...

    Science.gov (United States)

    2011-12-29

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 52-016; NRC-2008-0250] UniStar Nuclear Energy; Combined License Application for Calvert Cliffs Nuclear Power Plant, Unit 3; Exemption 1.0 Background: UniStar Nuclear Energy (UNE) submitted to the U.S. Nuclear Regulatory Commission (NRC or the Commission ) a...

  1. 76 FR 11522 - In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear...

    Science.gov (United States)

    2011-03-02

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 52-029-COL, 52-030-COL] In the Matter of Progress Energy Florida, Inc. (Combined License Application, Levy County Nuclear Power Plant, Units 1 and 2... by the Nuclear Regulatory Commission staff in this case. Mr. Dehmel has not previously performed any...

  2. 78 FR 61984 - Copper Valley Electric Association, Inc.; Notice of Application To Amend License and Accepted for...

    Science.gov (United States)

    2013-10-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 13124-005] Copper Valley...: Amendment to License. b. Project No: 13124-005. c. Date Filed: September 27, 2013. d. Applicant: Copper..., Copper Valley Electric Association, Inc., P.O. Box 45, Mile 187 Glenn Highway, Glennallen, AK 99588, (907...

  3. Mammalian synthetic biology: emerging medical applications.

    Science.gov (United States)

    Kis, Zoltán; Pereira, Hugo Sant'Ana; Homma, Takayuki; Pedrigi, Ryan M; Krams, Rob

    2015-05-06

    In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology. We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON-OFF switches, categorized into transcriptional, post-transcriptional, translational and post-translational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug discovery, drug delivery, receptor-activating gene circuits and mammalian biomanufacturing processes. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

  4. Systems engineering and the licensing of Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Kulesa, T., E-mail: tkulesa@us.ibm.com [IBM, Philidelphia, Pennsylvania (United States); Soderholm, K., E-mail: Kristiina.Soderholm@fortum.com [Fortum Power (Finland); Fechtelkotter, P., E-mail: pfech@us.ibm.com [IBM, Boston, Massacheusets (United States)

    2014-07-01

    Both global warming and the need for dependable sources of energy continue to make nuclear power generation an appealing option. But a history of cost overruns, project delays, and environmental disaster has pushed the industry to innovate and design a more flexible, scalable, and safe source of nuclear energy - the small modular reactor. Innovation in generation technology creates disruption in already complex licensing and regulatory processes. This paper discusses how the application of systems engineering and requirements management can help combat confusion, rework, and efficiency problems across the engineering and compliance life cycle. The paper is based on the PhD Dissertation 'Licensing Model Development for Small Modular Reactors (SMRs) - Focusing on Finnish Regulatory Framework', approved in 2013. The result of the study gives recommendations and tools to develop and optimize the licensing process for SMRs. The most important SMR-specific feature, in terms of licensing, is the modularity of the design. Here the modularity indicates multi-module SMR designs, which creates new challenges in the licensing process. Another feature impacting licensing feasibility is the plan to build many standardized power plants in series and use factory-fabricated modules to optimize the construction costs. SMR licensing challenges are under discussion in many international forums, such as World Nuclear Association Cooperation in Reactor Design Evaluation and Licensing Small Modular Reactor group (WNA CORDEL SMR) group and IAEA INPRO regulators' forum. This paper also presents an application of the new licensing process using Systems Engineering, Requirements Management, and Project Management practices and tools. (author)

  5. Systems engineering and the licensing of Small Modular Reactors

    International Nuclear Information System (INIS)

    Kulesa, T.; Soderholm, K.; Fechtelkotter, P.

    2014-01-01

    Both global warming and the need for dependable sources of energy continue to make nuclear power generation an appealing option. But a history of cost overruns, project delays, and environmental disaster has pushed the industry to innovate and design a more flexible, scalable, and safe source of nuclear energy - the small modular reactor. Innovation in generation technology creates disruption in already complex licensing and regulatory processes. This paper discusses how the application of systems engineering and requirements management can help combat confusion, rework, and efficiency problems across the engineering and compliance life cycle. The paper is based on the PhD Dissertation 'Licensing Model Development for Small Modular Reactors (SMRs) - Focusing on Finnish Regulatory Framework', approved in 2013. The result of the study gives recommendations and tools to develop and optimize the licensing process for SMRs. The most important SMR-specific feature, in terms of licensing, is the modularity of the design. Here the modularity indicates multi-module SMR designs, which creates new challenges in the licensing process. Another feature impacting licensing feasibility is the plan to build many standardized power plants in series and use factory-fabricated modules to optimize the construction costs. SMR licensing challenges are under discussion in many international forums, such as World Nuclear Association Cooperation in Reactor Design Evaluation and Licensing Small Modular Reactor group (WNA CORDEL SMR) group and IAEA INPRO regulators' forum. This paper also presents an application of the new licensing process using Systems Engineering, Requirements Management, and Project Management practices and tools. (author)

  6. Roundtable discussion: Materials management issues supporting licensing renewal

    International Nuclear Information System (INIS)

    1991-01-01

    The purpose of this technical session is to discussion the relationships between nuclear materials management/procurement engineering and plant license renewal. The basis for the discussion is DG-1009 'Standard format and content of technical information for applications to renew nuclear power plant operating licenses', dated 12/90

  7. The Texas concurrent characterization, licensing, and development process

    Energy Technology Data Exchange (ETDEWEB)

    Avant, R.V. Jr. [Texas Low-Level Radioactive Waste Disposal Authority, Austin, TX (United States)

    1993-03-01

    The 72nd Texas Legislature specifically delineated a 400-square-mile area in southeast Hudspeth County where siting activities would be limited. The Authority was given unprecedented powers of property access and eminent domain and expanded budget authority to conduct site selection, characterization, and licensing. In the summer of 1991, the Authority identified five general siting areas in the prescribed region, and in the fall of 1991, the Authority narrowed the siting area to one large ranch composed of about 16,000 acres--called the Faskin Ranch. Site characterization began in 1991 and will be complete by September 1993. In September 1991, Authority staff began preparing the license application and included all available information on the Faskin Ranch. At its February meeting, the Authority`s board directed staff to submit the license application to the Texas Water Commission (the new Texas radiation control agency). The license application was submitted on March 2, 1992, and on April 15, 1992, the Commission determined that the application was sufficiently complete to begin review. Discrete technical packages such as groundwater hydrology, surface water hydrology, design, etc., will be submitted to the agency for review on the completion of each package. A schedule has been developed to allow the regulators the maximum time possible to review critical technical areas while minimizing the total review period.

  8. Dealing with the current permissibility application for constructing a spent fuel DGR in Sweden. SKB's license applications for a spent fuel repository

    International Nuclear Information System (INIS)

    Olsson, Olle

    2014-01-01

    The nuclear power utilities in Sweden were in 1976 obliged to demonstrate a safe method for final disposal of spent fuel in order to start operation of new reactors. This initiated a comprehensive research, development and demonstration programme and the development of the KBS-method for final disposal. A new Nuclear Activities Act in 1984 gave the reactor owners full technical and financial responsibility for the waste. They gave in turn SKB the responsibility for all nuclear waste management. Reprocessing was no longer required and direct disposal of the spent fuel has, since then, been the main alternative. Alternative methods for final disposal have been evaluated and compared to the KBS-3-method but it has remained the preferred alternative. A comprehensive research, development and demonstration programme to strengthen the scientific basis and to refine the KBS-3-method has been operated by SKB since then. The site selection process for the final repository for spent nuclear fuel was initiated in 1992. The work included general siting studies at the national and the municipal level and in 2002, SKB initiated site investigations for siting of a final repository on two sites: the Simpevarp and Laxemar areas and the Forsmark area. At the same time, the work on preparing license applications to construct and operate an encapsulation plant and a final repository for spent fuel was started. In June 2009, SKB announced Forsmark as the selected site for the final repository. This paper reviews the applicable legislation and describes the license application, the licensing review and the preparations for implementation

  9. Advanced CANDU reactor pre-licensing progress

    International Nuclear Information System (INIS)

    Popov, N.K.; West, J.; Snell, V.G.; Ion, R.; Archinoff, G.; Xu, C.

    2005-01-01

    The Advanced CANDU Reactor (ACR) is an evolutionary advancement of the current CANDU 6 reactor, aimed at producing electrical power for a capital cost and at a unit-energy cost significantly less than that of the current reactor designs. The Canadian Nuclear Safety Commission (CNSC) staff are currently reviewing the ACR design to determine whether, in their opinion, there are any fundamental barriers that would prevent the licensing of the design in Canada. This CNSC licensability review will not constitute a licence, but is expected to reduce regulatory risk. The CNSC pre-licensing review started in September 2003, and was focused on identifying topics and issues for ACR-700 that will require a more detailed review. CNSC staff reviewed about 120 reports, and issued to AECL 65 packages of questions and comments. Currently CNSC staff is reviewing AECL responses to all packages of comments. AECL has recently refocused the design efforts to the ACR-1000, which is a larger version of the ACR design. During the remainder of the pre-licensing review, the CNSC review will be focused on the ACR-1000. AECL Technologies Inc. (AECLT), a wholly-owned US subsidiary of AECL, is engaged in a pre-application process for the ACR-700 with the US Nuclear Regulatory Commission (USNRC) to identify and resolve major issues prior to entering a formal process to obtain standard design certification. To date, the USNRC has produced a Pre-Application Safety Assessment Report (PASAR), which contains their reviews of key focus topics. During the remainder of the pre-application phase, AECLT will address the issues identified in the PASAR. Pursuant to the bilateral agreement between AECL and the Chinese nuclear regulator, the National Nuclear Safety Administration (NNSA) and its Nuclear Safety Center (NSC), NNSA/NSC are reviewing the ACR in seven focus areas. The review started in September 2004, and will take three years. The main objective of the review is to determine how the ACR complies

  10. Microsoft Biology Initiative: .NET Bioinformatics Platform and Tools

    Science.gov (United States)

    Diaz Acosta, B.

    2011-01-01

    The Microsoft Biology Initiative (MBI) is an effort in Microsoft Research to bring new technology and tools to the area of bioinformatics and biology. This initiative is comprised of two primary components, the Microsoft Biology Foundation (MBF) and the Microsoft Biology Tools (MBT). MBF is a language-neutral bioinformatics toolkit built as an extension to the Microsoft .NET Framework—initially aimed at the area of Genomics research. Currently, it implements a range of parsers for common bioinformatics file formats; a range of algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to biological web services such as NCBI BLAST. MBF is available under an open source license, and executables, source code, demo applications, documentation and training materials are freely downloadable from http://research.microsoft.com/bio. MBT is a collection of tools that enable biology and bioinformatics researchers to be more productive in making scientific discoveries.

  11. SKB's safety case for a final repository license application

    International Nuclear Information System (INIS)

    Hedin, Allan; Andersson, Johan

    2014-01-01

    The safety assessment SR-Site is a main component in SKB's license application, submitted in March 2011, to construct and operate a final repository for spent nuclear fuel at Forsmark in the municipality of Oesthammar, Sweden. Its role in the application is to demonstrate long-term safety for a repository at Forsmark. The assessment relates to the KBS-3 disposal concept in which copper canisters with a cast iron insert containing spent nuclear fuel are surrounded by bentonite clay and deposited at approximately 500 m depth in saturated, granitic rock. The principal regulatory acceptance criterion, issued by the Swedish Radiation Safety Authority (SSM), requires that the annual risk of harmful effects after closure not exceed 10 -6 for a representative individual in the group exposed to the greatest risk. SSM's regulations also imply that the assessment time for a repository of this type is one million years after closure. The licence applied for is one in a stepwise series of permits, each requiring a safety report. The next step concerns a permit to start excavation of the repository and requires a preliminary safety assessment report (PSAR) covering both operational and post-closure safety. Later steps include permission to commence trial operation, to commence regular operation and to close the final repository. (authors)

  12. Nuclear Safety Design Base for License Application

    International Nuclear Information System (INIS)

    R.J. Garrett

    2005-01-01

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111(b) [DIRS 173273] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113(b) and (c) [DIRS 173273] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period

  13. 78 FR 5196 - Notice of Invitation To Participate; Exploration for Coal in Colorado License Application COC-75642

    Science.gov (United States)

    2013-01-24

    ...] Notice of Invitation To Participate; Exploration for Coal in Colorado License Application COC-75642... Mineral Leasing Act of 1920, as amended by the Federal Coal Leasing Amendments Act of 1976, and to Bureau..., Colorado. DATES: Any party electing to participate in this exploration program must send written notice to...

  14. 75 FR 32983 - Commercial Driver's License (CDL) Standards: Exemption

    Science.gov (United States)

    2010-06-10

    ...-28480] Commercial Driver's License (CDL) Standards: Exemption AGENCY: Federal Motor Carrier Safety... commercial driver's license (CDL) as required by current regulations. FMCSA reviewed NAAA's application for... demonstrate alternatives its members would employ to ensure that their commercial motor vehicle (CMV) drivers...

  15. Postulated licensing schedule for an independent spent-fuel-storage installation

    International Nuclear Information System (INIS)

    Ludwick, J.D.

    1982-11-01

    A review of licensing requirements, processes, and anticipated actions for independent spent fuel storage installations (ISFSIs) was conducted in order to develop an estimated schedule and sequence of events for licensing a new ISFSI. This estimate will be useful to potential ISFSI owners in planning for the licensing of their facilities. It is concluded that, although many uncertainties exist with respect to such things as legal appeals, about 29 months are estimated to elapse between license application and license issuance for an ISFSI. This estimate is in reasonable agreement with a previous time estimate for licensing an ISFSI, and, taking into account the special circumstances involved, with the actual licensing schedule for the GE-Morris ISFSI. However, individual portions of the licensing schedule from each case studied sometimes vary significantly

  16. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  17. Total System Performance Assessment - License Application Methods and Approach

    Energy Technology Data Exchange (ETDEWEB)

    J. McNeish

    2003-12-08

    ''Total System Performance Assessment-License Application (TSPA-LA) Methods and Approach'' provides the top-level method and approach for conducting the TSPA-LA model development and analyses. The method and approach is responsive to the criteria set forth in Total System Performance Assessment Integration (TSPAI) Key Technical Issues (KTIs) identified in agreements with the U.S. Nuclear Regulatory Commission, the ''Yucca Mountain Review Plan'' (YMRP), ''Final Report'' (NRC 2003 [163274]), and the NRC final rule 10 CFR Part 63 (NRC 2002 [156605]). This introductory section provides an overview of the TSPA-LA, the projected TSPA-LA documentation structure, and the goals of the document. It also provides a brief discussion of the regulatory framework, the approach to risk management of the development and analysis of the model, and the overall organization of the document. The section closes with some important conventions that are used in this document.

  18. 77 FR 39675 - Applications for Licensing as a Non-Leveraged Rural Business Investment Company Under the Rural...

    Science.gov (United States)

    2012-07-05

    ... large 3-ring binder. Label the binders with the RBIC's name. Submit one complete and unbound one-sided hard copy of the MAQ and Exhibits suitable for photocopying (i.e., no hole punches, staples, paper clips, tabs or binders). Applicants must enclose in their submission a nonrefundable licensing fee of...

  19. 76 FR 55701 - Notice of Invitation to Participate; Exploration for Coal in Colorado License Application COC-74895

    Science.gov (United States)

    2011-09-08

    ...] Notice of Invitation to Participate; Exploration for Coal in Colorado License Application COC-74895... Mineral Leasing Act of 1920, as amended by the Federal Coal Leasing Amendments Act of 1976, and to Bureau... coal deposits owned by the United States of America in lands located in Routt County, Colorado. DATES...

  20. Studying cell biology in the skin.

    Science.gov (United States)

    Morrow, Angel; Lechler, Terry

    2015-11-15

    Advances in cell biology have often been driven by studies in diverse organisms and cell types. Although there are technical reasons for why different cell types are used, there are also important physiological reasons. For example, ultrastructural studies of vesicle transport were aided by the use of professional secretory cell types. The use of tissues/primary cells has the advantage not only of using cells that are adapted to the use of certain cell biological machinery, but also of highlighting the physiological roles of this machinery. Here we discuss advantages of the skin as a model system. We discuss both advances in cell biology that used the skin as a driving force and future prospects for use of the skin to understand basic cell biology. A unique combination of characteristics and tools makes the skin a useful in vivo model system for many cell biologists. © 2015 Morrow and Lechler. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  1. SSM's licensing review of a spent nuclear fuel repository in Sweden

    International Nuclear Information System (INIS)

    Dverstorpand, Bjoern; Stroemberg, Bo

    2014-01-01

    On 16 March 2011 the Swedish Nuclear Fuel and Waste Management Co. (SKB) submitted license applications for a general license to construct, possess and operate a KBS-3 type spent nuclear fuel repository at the Forsmark site, in Oesthammar municipality, and an encapsulation plant in Oskarshamn municipality. The KBS-3 method, which has been developed by SKB over a period of more than 30 years, entails disposing of the spent fuel in copper canisters, surrounded by a swelling bentonite clay, at about 500 m depth in crystalline basement rock. SKB's applications are being evaluated in parallel by the Swedish Radiation Safety Authority (SSM) according to the Act on Nuclear Activities and by the Land and Environmental Court according to the Environmental Code. During the review SSM will act as an expert review body to the Land and Environmental Court in the areas of radiation protection, safety and security/non-proliferation. Both SSM and the court will produce a statement with a recommendation regarding a licensing decision and licensing conditions to the government. The government will make the final decision after consulting the municipalities concerned by SKB's facilities (municipal veto applies). The current licensing decision is just one of several licensing decisions that will be required for the repository. However it is arguably the most important one, because it is the last licensing stage with a broad societal involvement including an environmental impact assessment (EIA) process, national consultations and municipal veto for the concerned municipalities. The licensing steps to follow, should SKB be granted a license by the government, only require approval by SSM. These steps include application for start of actual construction work, test operation and routine operation. (authors)

  2. 10 CFR 780.45 - Criteria for decision to issue a license.

    Science.gov (United States)

    2010-01-01

    .... A license shall issue to the applicant to use the invention covered by the patent for the purposes stated in the application upon a final decision that: (a) The invention or discovery covered by the... energy; (b) The licensing of such invention or discovery is of primary importance to the conduct of the...

  3. Biocompatible Quantum Dots for Biological Applications

    Science.gov (United States)

    Rosenthal, Sandra J.; Chang, Jerry C.; Kovtun, Oleg; McBride, James R.; Tomlinson, Ian D.

    2011-01-01

    Semiconductor quantum dots are quickly becoming a critical diagnostic tool for discerning cellular function at the molecular level. Their high brightness, long-lasting, sizetunable, and narrow luminescence set them apart from conventional fluorescence dyes. Quantum dots are being developed for a variety of biologically oriented applications, including fluorescent assays for drug discovery, disease detection, single protein tracking, and intracellular reporting. This review introduces the science behind quantum dots and describes how they are made biologically compatible. Several applications are also included, illustrating strategies toward target specificity, and are followed by a discussion on the limitations of quantum dot approaches. The article is concluded with a look at the future direction of quantum dots. PMID:21276935

  4. Guide to request license for industrial X-rays practices

    International Nuclear Information System (INIS)

    2000-05-01

    In this work the instructions it plows described to request license for practices it of industrial x-ray it continued. The instructions but important: they plows license type, purpose of the application, source and equipment, location of local the, program of radiological protection and security

  5. 77 FR 38771 - Prospective Grant of Exclusive Patent License

    Science.gov (United States)

    2012-06-29

    ... Exclusive Patent License AGENCY: National Institute of Standards and Technology, Department of Commerce. ACTION: Notice of prospective grant of exclusive patent license. SUMMARY: This is a notice in accordance... embodied in U.S. Patent Application No. 13/346,999 titled ``Chirped-Pulse Terahertz Spectroscopy for...

  6. ITER licensing

    International Nuclear Information System (INIS)

    Gordon, C.W.

    2005-01-01

    ITER was fortunate to have four countries interested in ITER siting to the point where licensing discussions were initiated. This experience uncovered the challenges of licensing a first of a kind, fusion machine under different licensing regimes and helped prepare the way for the site specific licensing process. These initial steps in licensing ITER have allowed for refining the safety case and provide confidence that the design and safety approach will be licensable. With site-specific licensing underway, the necessary regulatory submissions have been defined and are well on the way to being completed. Of course, there is still work to be done and details to be sorted out. However, the informal international discussions to bring both the proponent and regulatory authority up to a common level of understanding have laid the foundation for a licensing process that should proceed smoothly. This paper provides observations from the perspective of the International Team. (author)

  7. Technology neutral licensing requirements: have we been successful?

    International Nuclear Information System (INIS)

    Jamieson, T.

    2009-01-01

    The Canadian Nuclear Safety Commission (CNSC) is Canada's nuclear regulator. In preparation for the licensing of the next generation of nuclear reactors in Canada, the CNSC has made major changes in its processes and procedures associated with all aspects of the licensing life cycle. These include: development of key regulatory documents outlining the CNSC expectations for the design and siting of new reactors; creation of applicant guidelines for completing licensing applications; creation of a comprehensive set of review guides, specifying how topics in applications are to be reviewed; performing pre-project design reviews for proposed new reactor technologies; and streamlining processes wherever possible, such as performing the environmental assessment and license to prepare site activities in parallel. The predicted workload associated with the nuclear renaissance in Canada is real. The CNSC is currently performing: 4 pre-project design reviews (for AECL's ACR-1000 and EC-6, Areva's EPR and Westinghouse's AP-1000), has received applications for 4 new builds (at Darlington, Bruce, Nanticoke and in Alberta) and is in the midst of performing the combined environmental assessment and license to prepare site phases for these sites. This is in addition to the work associated with: the licensing of new uranium mines; oversight of the existing reactor fleet; refurbishments at Bruce/Gentilly/Point Lepreau; license renewal for the NRU reactor; and oversight of our general client base of over 5000 licensees. In this presentation, experience to date with these new processes and procedures will be discussed, including: status of the current new build projects; anticipated new activities; lessons learned, especially the technology neutral approach; application to our other licensed activities, including non-power reactors; and work underway to further develop CNSC methods. Qualifications Needed to Design, Construct and Manufacture Nuclear Systems and Equipment, C. Voutsinos

  8. 75 FR 69063 - Port Bailey Wild Enterprises, LLC; PB Energy, Inc.; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-11-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 1432-010] Port Bailey Wild... Motions To Intervene November 3, 2010. On October 22, 2010, Port Bailey Wild Enterprises, LLC (transferor) and PB Energy, Inc. (transferee) filed a joint application for transfer of license for the Dry Spruce...

  9. Applications of Microfluidics in Quantitative Biology.

    Science.gov (United States)

    Bai, Yang; Gao, Meng; Wen, Lingling; He, Caiyun; Chen, Yuan; Liu, Chenli; Fu, Xiongfei; Huang, Shuqiang

    2018-05-01

    Quantitative biology is dedicated to taking advantage of quantitative reasoning and advanced engineering technologies to make biology more predictable. Microfluidics, as an emerging technique, provides new approaches to precisely control fluidic conditions on small scales and collect data in high-throughput and quantitative manners. In this review, the authors present the relevant applications of microfluidics to quantitative biology based on two major categories (channel-based microfluidics and droplet-based microfluidics), and their typical features. We also envision some other microfluidic techniques that may not be employed in quantitative biology right now, but have great potential in the near future. © 2017 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences. Biotechnology Journal Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  10. AP1000{sup R} licensing and deployment in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Jordan, R. P.; Russ, P. A.; Filiak, P. P.; Castiglione, L. L. [Westinghouse Electric Company LLC, 1000 Westinghouse Drive, Cranberry Township, PA 16066 (United States)

    2012-07-01

    In recent years, both domestic and foreign utilities have turned to the standardized Westinghouse AP1000 plant design in satisfying their near - and long-term - sustainable energy needs. As direct support to these actions, licensing the AP1000 design has played a significant role by providing one of the fundamental bases in clearing regulatory hurdles leading to the start of new plant construction. Within the U.S. alone, Westinghouse AP1000 licensing activities have reached unprecedented milestones with the approvals of both AP1000 Design Certification and Southern Company's combined construction permit and operating license (COL) application directly supporting the construction of two new nuclear plants in Georgia. Further COL application approvals are immediately pending for an additional two AP1000 plants in South Carolina. And, across the U.S. nuclear industry spectrum, there are 10 other COL applications under regulatory review representing some 16 new plants at 10 sites. In total, these actions represent the first wave of new plant licensing under the regulatory approval process since 1978. Fundamental to the Nuclear Regulatory Commission's AP1000 Design Certification is the formal recognition of the AP1000 passive safety design through regulatory acceptance rulemaking. Through recognition and deployment of the AP1000 Design Certification, the utility licensee / operator of this reactor design are now offered an opportunity to use a simplified 'one-step' combined license process, thereby managing substantial back-end construction schedule risk from regulatory and intervention delays. Application of this regulatory philosophy represents both acceptance and encouragement of standardized reactor designs like the AP1000. With the recent AP1000 Design Certification and utility COL acceptances, the fundamental licensing processes of this philosophy have successfully proven the attainment of significant milestones with the next stage licensing

  11. 10 CFR 40.33 - Issuance of a license for a uranium enrichment facility.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Issuance of a license for a uranium enrichment facility... License Applications § 40.33 Issuance of a license for a uranium enrichment facility. (a) The Commission... the licensing of the construction and operation of a uranium enrichment facility. The Commission will...

  12. A BWR licensing experience in the USA

    International Nuclear Information System (INIS)

    Powers, J.; Ogura, C.; Arai, K.; Thomas, S.; Mookhoek, B.

    2015-09-01

    The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

  13. A BWR licensing experience in the USA

    Energy Technology Data Exchange (ETDEWEB)

    Powers, J.; Ogura, C. [Toshiba America Nuclear Energy, Charlotte, North Carolina (United States); Arai, K. [Toshiba Corporation, Yokohama, Kanagawa (Japan); Thomas, S.; Mookhoek, B., E-mail: jim.powers@toshiba.com [Nuclear Innovation North America, Lake Jackson, Texas (United States)

    2015-09-15

    The US-Advanced Boiling Water Reactor (A BWR), certified by the United States Nuclear Regulatory Commission (US NRC), is a third generation, evolutionary boiling water reactor design which is the reference for the South Texas Project Units 3 and 4 (STP3-4) Combined License Application (Cola). Nuclear Innovation North America (Nina) is the License Applicant for this new build project, and Toshiba is the selected primary technology contractor. The STP3-4 project has finished the US NRC technical review of the Cola through the final meeting of the Advisory Committee on Reactor Safeguards (ACRS), and the Final Safety Evaluation Report (FSER) is scheduled to be issued by the US NRC in the middle of 2015. The next steps are to support the Mandatory Hearing process, and voting by the NRC commissioners on the motion to grant the Combined License, which is scheduled beginning of 2016 according to US NRC schedule as of March 30, 2015. This paper summarizes the history and progress of the US-A BWR licensing, including the experiences of the Licensee, Nina, and Toshiba as the Epc team worked through the Code of Federal Regulations Title 10 (10-Cfr) Part 52 process, and provides some perspectives on how the related licensing material would also be of value within a 10-Cfr Part 50, two-step process to minimize schedule and financial risks which could arise from ongoing technical developments and regulatory reviews. (Author)

  14. License plate recognition (phase B).

    Science.gov (United States)

    2010-06-01

    License Plate Recognition (LPR) technology has been used for off-line automobile enforcement purposes. The technology has seen mixed success with correct reading rate as high as 60 to 80% depending on the specific application and environment. This li...

  15. 47 CFR 74.787 - Digital licensing.

    Science.gov (United States)

    2010-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.787 Digital licensing. (a) Applications for digital low power television and... channels may be filed at any time. Such applications shall be filed on FCC Form 346 and will be treated as...

  16. Licensing schedule for away-from-reactor (AFR) spent fuel storage facilities

    International Nuclear Information System (INIS)

    Gray, P.L.

    1981-08-01

    The Nuclear Regulatory Commission has authority to issue licenses for Away-From-Reactor (AFR) installations for the storage of spent nuclear fuel. This report presents a detailed estimate of the time required to prosecute a licensing action. The projected licensing schedule shows that the elapsed time between filing an application and issuance of a license will be about 32 months, assuming intervention. The legal procedural steps will determine the time schedule and will override considerations of technical complexity. A license could be issued in about 14 months in the absence of intervention

  17. A review of tritium licensing requirements

    International Nuclear Information System (INIS)

    Meikle, A.B.

    1982-12-01

    Present Canadian regulations and anticipated changes to these regulations relevant to the utilization of tritium in fusion facilities and in commercial applications have been reviewed. It is concluded that there are no serious licensing obstacles, but there are a number of requirements which must be met. A license will be required from Atomic Energy Control Board if Ontario Hydro tritium is to be applied by other users. A license is required from the Federal Government to export or import tritium. A licensed container will be required for the storage and shipping of tritium. The containers being designed by AECL and Ontario Hydro and which are currently being tested will adequately store and ship all of the Ontario Hydro tritium but are unnecessarily large for the small quantities required by the commercial tritium users. Also, some users may prefer to receive tritium in gaseous form. An additional, smaller container should be considered. The licensing of overseas fusion facilities for the use of tritium is seen as a major undertaking offering opportunities to Canadian Fusion Fuels Technology Project to undertake health, safety and environmental analysis on behalf of these facilities

  18. 77 FR 3273 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2012-01-23

    ... Technology: Available for licensing is a novel method using short-term treatment with a glucocorticoid...: Licensing information and copies of the U.S. patent applications listed below may be obtained by writing to... into memory cells and terminally differentiated plasma cells. Moreover, IL-21 has anti-tumor activity...

  19. 77 FR 65673 - Prospective Grant of Exclusive Patent License

    Science.gov (United States)

    2012-10-30

    ... Exclusive Patent License AGENCY: National Institute of Standards and Technology, Commerce. ACTION: Notice of prospective grant of exclusive patent license. SUMMARY: This is a notice in accordance with 35 U.S.C. 209(e.... Patent Application No. 61/625,511 titled ``UV-Assisted Alcohol Sensing with Zinc Oxide Functionalized...

  20. Methodology to identify, review, and evaluate components for license renewal

    International Nuclear Information System (INIS)

    Carlson, D.D.; Gregor, F.E.; Walker, R.S.

    1988-01-01

    A methodology has been developed to systematically identify, review, and evaluate plant equipment for license renewal. The method builds upon the existing licensing basis, operating history, and accepted deterministic and probabilistic techniques. Use of these approaches provides a focus for license renewal upon those safety-significant systems and components that are not routinely replaced, refurbished, or subject to detailed inspection as part of the plant's existing test, maintenance, and surveillance programs. Application of the method identified the PWR and BWR systems that should be subjected to detailed license renewal review. Detailed examination of two example systems demonstrates the approach. The review and evaluation of plant equipment for license renewal differ from the initial licensing of the plant. A substantial operating history has been established, the licensing basis has evolved from the original one, and plant equipment has been subject to periodic maintenance and surveillance throughout its life. In consideration of these differences, a basis for license renewal is needed. License renewal should be based upon continuation of the existing licensing basis and recognition of existing programs and operating history

  1. Microautoradiographic methods and their applications in biology

    International Nuclear Information System (INIS)

    Benes, L.

    1978-01-01

    A survey of microautoradiographic methods and of their application in biology is given. The current state of biological microautoradiography is shown, focusing on the efficiency of techniques and on special problems proceeding in autoradiographic investigations in biology. Four more or less independent fields of autoradiography are considered. In describing autoradiographic techniques two methodological tasks are emphasized: The further development of the labelling technique in all metabolic studies and of instrumentation and automation of autoradiograph evaluation. (author)

  2. 77 FR 63343 - Biweekly Notice: Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-10-16

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... for an inoperable diesel generator (DG). A commensurate change is also proposed to extend the maximum... alternating current power source (i.e., a supplemental diesel generator) with the capability to power any E...

  3. 77 FR 73684 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-12-11

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... emergency diesel generator, and the stored lube oil inventory will also continue to require that a 7-day supply be available for each diesel generator. The changes are consistent with NRC-approved Technical...

  4. Licensing and Environmental Issues of Wave Energy Projects

    DEFF Research Database (Denmark)

    Neumann, Frank; Tedd, James; Prado, Miguel

    2006-01-01

    a special standing or facilitated access to operating licenses due to their experimental character, the move of wave energy projects towards commercial applications implies complex procedures for obtaining licenses both with respect to the construction and deployment and operation phases, as well......The major non-technical barrier for large-scale wave energy implementation is the wide range of licensing issues and potential environmental concerns, in addition to significant National/regional differences in licensing procedures and permit requirements. Whereas some pilot plants have had...... as concerning ocean space use and environmental concerns. Despite recent efforts to streamline European EIA (Environmental Impact Assessment) in general, potential project developers are far from having a clear view of present and future requirements concerning these barriers on a trans-national level...

  5. Review of Biological Network Data and Its Applications

    Directory of Open Access Journals (Sweden)

    Donghyeon Yu

    2013-12-01

    Full Text Available Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.

  6. Introduction to Technology Export License of Nuclear Facility

    Energy Technology Data Exchange (ETDEWEB)

    Seo, Hana; Lee, Chansuh; Shin, Donghoon [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

    2014-05-15

    In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry.

  7. Introduction to Technology Export License of Nuclear Facility

    International Nuclear Information System (INIS)

    Seo, Hana; Lee, Chansuh; Shin, Donghoon

    2014-01-01

    In this regime, the Nuclear Safety and Security Commission (NSSC) has authority on final decision making. And the Korea Institute of Nuclear nonproliferation and Control (KINAC) has missions to review the classification and export licensing technically. In principle, classification and export licensing are applied and reviewed individually. However, the number of application for classification and licensing has increased geometrically in the last three years. This is largely a due to the contract that the Republic of Korea (ROK) has finalized to build the UAE Barakah Nuclear Power Plant (BNPP) and Jordan Research and Training Reactor (JRTR). This circumstance brought an administrative burden for the government and related institutes as well as stakeholders. This article introduces the law related to the 'Technology Export License of Nuclear Facility' which was developed and legislated to improve the efficiency and effectiveness of commodities classification and export licensing. This system could significantly reduce the licensing burden for transferring the technologies. However, the classification and license on this system are still requested when transferring the goods. Therefore, KINAC will continue to figure out the needs for the stakeholders and keep searching for solutions to problems inherent in the industry

  8. Why trash don't pass? pharmaceutical licensing and safety performance of drugs.

    Science.gov (United States)

    Banerjee, Tannista; Nayak, Arnab

    2017-01-01

    This paper examines how asymmetric information in pharmaceutical licensing affects the safety standards of licensed drugs. Pharmaceutical companies often license potential drug molecules at different stages of drug development from other pharmaceutical or biotechnology companies and complete the remaining of research stages before submitting the new drug application(NDA) to the food and drug administration. The asymmetric information associated with the quality of licensed molecules might result in the molecules which are less likely to succeed to be licensed out, while those with greater potential of success being held internally for development. We identify the NDAs submitted between 1993 and 2004 where new molecular entities were acquired through licensing. Controlling for other drug area specific and applicant firm specific factors, we investigate whether drugs developed with licensed molecules face higher probability of safety based recall and ultimate withdrawal from the market than drugs developed internally. Results suggest the opposite of Akerlof's (Q J Econ 84:488-500, 1970) lemons problem. Licensed molecules rather have less probability of facing safety based recalls and ultimate withdrawal from the market comparing to internally developed drug molecules. This suggests that biotechnology and small pharmaceutical firms specializing in pharmaceutical research are more efficient in developing good potential molecules because of their concentrated research. Biotechnology firms license out good potential molecules because it increases their market value and reputation. In addition, results suggest that both the number of previous approved drugs in the disease area, and also the applicant firms' total number of previous approvals in all disease areas reduce the probability that an additional approved drug in the same drug area will potentially be harmful.

  9. Advances in Structural Biology and the Application to Biological Filament Systems.

    Science.gov (United States)

    Popp, David; Koh, Fujiet; Scipion, Clement P M; Ghoshdastider, Umesh; Narita, Akihiro; Holmes, Kenneth C; Robinson, Robert C

    2018-04-01

    Structural biology has experienced several transformative technological advances in recent years. These include: development of extremely bright X-ray sources (microfocus synchrotron beamlines and free electron lasers) and the use of electrons to extend protein crystallography to ever decreasing crystal sizes; and an increase in the resolution attainable by cryo-electron microscopy. Here we discuss the use of these techniques in general terms and highlight their application for biological filament systems, an area that is severely underrepresented in atomic resolution structures. We assemble a model of a capped tropomyosin-actin minifilament to demonstrate the utility of combining structures determined by different techniques. Finally, we survey the methods that attempt to transform high resolution structural biology into more physiological environments, such as the cell. Together these techniques promise a compelling decade for structural biology and, more importantly, they will provide exciting discoveries in understanding the designs and purposes of biological machines. © 2018 The Authors. BioEssays Published by WILEY Periodicals, Inc.

  10. 77 FR 70837 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-11-27

    ... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... request: The proposed change will delete Function 14, SG [Steam Generator] Water Level--Low, Coincident... capability to shut down the reactor when required on Low--Low Steam Generator water level. The ability to...

  11. 78 FR 16876 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2013-03-19

    ... intervene shall be filed in accordance with the Commission's ``Rules of Practice for Domestic Licensing... proposes to replace the VHS with an onsite diesel generator as the AAC power source providing this... power source (the VHS) with an additional onsite AAC power source (diesel generator). This equipment can...

  12. 77 FR 67679 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2012-11-13

    ... diesel generator surveillance requirements. Margin of safety is related to the ability of the fission... evaluated; or (3) involve a significant reduction in a margin of safety. The basis for this proposed... accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10 CFR Part 2...

  13. 78 FR 14126 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses and Combined Licenses...

    Science.gov (United States)

    2013-03-04

    ... in accordance with the Commission's ``Rules of Practice for Domestic Licensing Proceedings'' in 10... of the document. The E-Filing system also distributes an email notice that provides access to the... Completion Time has no impact on the consequences of any design basis accident since the consequences of an...

  14. Siting Practices and Site Licensing Process for New Reactors in Canada

    International Nuclear Information System (INIS)

    Vos, Marcel de

    2011-01-01

    'Siting' in Canada is composed of Site Evaluation and Site Selection. As outlined in CNSC Regulatory Document RD-346 Site Evaluation for New Nuclear Power Plants (based on IAEA NS-R-3), prior to the triggering of the Environmental Assessment (EA) and licensing processes, the proponent is expected to use a robust process to characterize proposed sites over the full life cycle of the facility, and then develop a fully documented defense of the site selection case. This case forms the backbone for submissions in support of the EA and the application for a License to Prepare Site which will be reviewed by the CNSC and other applicable federal authorities. The Environmental Assessment process and License to Prepare Site in Canada do not require a proponent to select a specific design; however, CNSC does not accept a 'black box' approach to siting. CNSC balances the level of design information required with the extent of safety assurance desired for any designs being contemplated for the proposed site. Nevertheless, the design information submitted must be sufficient to justify the site as suitable for all future licensing stages. The depth of plant design information contributes significantly to the credibility of the applicant's case for both the EA and application for License to Prepare Site. The review process utilizes an assessment plan with defined review stages and timelines. The outcome of these reviews is a series of recommendations to a federal government appointed Joint Review Panel (which also serves as a panel of the 'Commission') which, following public hearings, renders a decision regarding the EA, and subsequently, the application for a License to Prepare Site. (author)

  15. The Licensing of New Nuclear Power Plants in Europe

    International Nuclear Information System (INIS)

    Raetzke, C.

    2008-01-01

    After an introduction dealing with the nuclear Renaissance in Europe and the specific situation of Germany and of Italy, the article focuses on the question of licensing processes for new reactors. New nuclear power plant projects involve a substantial investment and electric utilities will only take this decision if the licensing and regulatory risk can be adequately managed. Licensing processes should be predictable and efficient in order to give sufficient assurance to applicants. The article discusses best practice in licensing by giving some examples of suitable licensing processes of other countries. It also highlights international initiatives aimed at harmonizing safety requirements for new reactors and a multinational cooperation in reactor design review. These issues should be carefully considered by any country wanting to get new nuclear started. [it

  16. 77 FR 3773 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2012-01-25

    .... Hartwig Gdynia dba C. Hartwig Transport (NVO), 7, Derdowskiego Street, 81-369 Gdynia, Poland. Officers...: New OFF License. Cheryl G. Wilson dba JC Logistics (NVO & OFF), 28612 Redondo Beach Drive South, Des...: Add NVO Service. CR & J Logistics, Inc. dba Brightwater Shipping Services (NVO & OFF), 8401 Lake Worth...

  17. The molecular biology capstone assessment: a concept assessment for upper-division molecular biology students.

    Science.gov (United States)

    Couch, Brian A; Wood, William B; Knight, Jennifer K

    2015-03-02

    Measuring students' conceptual understandings has become increasingly important to biology faculty members involved in evaluating and improving departmental programs. We developed the Molecular Biology Capstone Assessment (MBCA) to gauge comprehension of fundamental concepts in molecular and cell biology and the ability to apply these concepts in novel scenarios. Targeted at graduating students, the MBCA consists of 18 multiple-true/false (T/F) questions. Each question consists of a narrative stem followed by four T/F statements, which allows a more detailed assessment of student understanding than the traditional multiple-choice format. Questions were iteratively developed with extensive faculty and student feedback, including validation through faculty reviews and response validation through student interviews. The final assessment was taken online by 504 students in upper-division courses at seven institutions. Data from this administration indicate that the MBCA has acceptable levels of internal reliability (α=0.80) and test-retest stability (r=0.93). Students achieved a wide range of scores with a 67% overall average. Performance results suggest that students have an incomplete understanding of many molecular biology concepts and continue to hold incorrect conceptions previously documented among introductory-level students. By pinpointing areas of conceptual difficulty, the MBCA can provide faculty members with guidance for improving undergraduate biology programs. © 2015 B. A. Couch et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. Licensing procedures for Low-Level Waste disposal facilities

    International Nuclear Information System (INIS)

    Roop, R.D.; Van Dyke, J.W.

    1985-09-01

    This report describes the procedures applicable to siting and licensing of disposal facilities for low-level radioactive wastes. Primary emphasis is placed on those procedures which are required by regulations, but to the extent possible, non-mandatory activities which will facilitate siting and licensing are also considered. The report provides an overview of how the procedural and technical requirements for a low-level waste (LLW) disposal facility (as defined by the Nuclear Regulatory Commission's Rules 10 CFR Parts 2, 51, and 61) may be integrated with activities to reduce and resolve conflict generated by the proposed siting of a facility. General procedures are described for site screening and selection, site characterization, site evaluation, and preparation of the license application; specific procedures for several individual states are discussed. The report also examines the steps involved in the formal licensing process, including docketing and initial processing, preparation of an environmental impact statement, technical review, hearings, and decisions. It is concluded that development of effective communication between parties in conflict and the utilization of techniques to manage and resolve conflicts represent perhaps the most significant challenge for the people involved in LLW disposal in the next decade. 18 refs., 6 figs

  19. U.S. licensing process and ABWR certification

    International Nuclear Information System (INIS)

    Quirk, J.F.; Williams, W.A.

    1996-01-01

    Part 50 of Title 10 of the Code of Federal Regulation (CFR) establishes a two-step licensing process by which the U.S. Nuclear Regulatory Committee (NRC) authorizes nuclear reactor plant construction through issuance of a construction permit and authorizes operation by issuance of an operating license. At each stage, the NRC Staff conducts technical reviews and there is potential for public hearings. In 1989, the NRC issued a new, simplified licensing process: Part 52. The purpose of the Part 52 licensing process is to provide a regulatory framework that brings about earlier resolution of licensing issues. Because issues are not resolved early in the Part 50 licensing process, approval of an operating license is not assured until after a significant investment has been made in the plant. Part 52 increases the stability and certainty of the licensing process by providing for the early resolution of safety and environmental issues. The Part 52 licensing process features (1) early site permits, (2) design certification, and (3) combined construction permit and operating licenses. As part of the U.S. Advanced Light Water Reactor (ALWR) Program to revitalize the nuclear option through the integration of government/utility/industry efforts, GE undertook the role of applying for certification for its latest product line, the Advanced Boiling Water Reactor (ABWR), under the U.S. ABWR certification program. The ABWR design is an essentially complete plant. Initial application for design certification was in 1987 under Part 50. GE reapplied in late 1991 under the newly promulgated Part 52. Following seven years of intensive interactions with the NRC and ACRS, GE was awarded the first Final Design Approval (FDA) under Part 52. The Commission initiated rulemaking by publishing the proposed ABWR Certification Rule in the Federal Register in early 1995. Certification is anticipated mid-1996. (J.P.N.)

  20. 76 FR 72409 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-11-23

    ... NVO Service. Pink City Logistics USA LLC (NVO & OFF), 7 Emily Road, Manalapan, NJ 07726; Officers... at (202) 523-5843 or by email at [email protected] . AE Eagle Logistics Inc. (NVO & OFF), 765 Route 83... License. Daybreak Logistics, Inc. (NVO & OFF), 2804 N. Cannon Blvd., Kannapolis, NC 28083; Officers...

  1. Librarian Certification and Licensing: A Brief Accounting.

    Science.gov (United States)

    Kaatrude, Peter B.

    1992-01-01

    Examines certification and licensing of librarians in the United States and Canada from the perspective of differences between the two concepts and through historical analysis of applications of each. A contextual framework for studying applications of these concepts to other professions is provided. (nine references) (MES)

  2. Status of the Monticello nuclear generating plant lead plant license renewal program

    International Nuclear Information System (INIS)

    Pickens, T.A.

    1992-01-01

    In 1988, the Monticello nuclear generating plant was chosen by the US Department of Energy through Sandia National Laboratories and the Electric Power Research Institute to serve as the lead boiling water reactor in the lead plant license renewal program. The purpose of the lead plant license renewal program is to provide insights during the development of and to demonstrate the license renewal regulatory process with the US Nuclear Regulatory Commission (NRC). The work being performed in three phases: (1) preparation of the technical basis for license renewal; (2) development of the technical basis into a formal license renewal application; and (3) review of the application by the NRC. This paper discusses the systems and structures identified as important to license renewal in accordance with 10CFR54 as well as the plant documents and programs that were used in going through the identification process. The systems and structures important to license renewal will then provide insights into how structures and components were identified that are required to be evaluated for aging, the elements of the aging evaluations, and the effective programs used to manage potentially significant aging

  3. Licensing the California low-level radioactive waste disposal facility

    International Nuclear Information System (INIS)

    Dressen, A.L.; Serie, P.J.; Junkert, R.

    1992-01-01

    California has made significant progress toward the issuance of a license to construct and operate the Southwestern Compact's low-level radioactive waste disposal facility. However, obstacles to completing construction and preparing to receive waste still exist. This paper will describe the technical licensing issues, EIR/S process, political events, and public interactions that have impacted on California regulators' ability to complete the license application review and reach a decision on issuing a license. Issues associated with safely and liability evaluations, finalization of the environmental impact report, and land transfer processes involving multiple state, federal, and local agencies will be identified. Major issues upon which public and political opposition is focusing will also be described. (author)

  4. License renewal

    International Nuclear Information System (INIS)

    Newberry, S.

    1993-01-01

    This article gives an overview of the process of license renewal for nuclear power plants. It explains what is meant by license renewal, the significance of license renewal, and goes over key elements involved in the process of license renewal. Those key elements are NRC requirements embodied in 10 CFR Part 54 (Reactor Safety) and 10 CFR Part 51 (Environmental Issues). In addition Industry Reports must be developed and reviewed. License renewal is essentially the process of applying for a 20 year extension to the original 40 year operating license granted for the plant. This is a very long term process, which involves a lot of preparation, and compliance with regulatory rules and guidelines. In general it is a process which is expected to begin when plants reach an operating lifetime of 20 years. It has provisions for allowing the public to become involved in the review process

  5. 77 FR 68155 - The Armed Forces Radiobiology Research Institute TRIGA Reactor: Facility Operating License No. R-84

    Science.gov (United States)

    2012-11-15

    ... Research Institute TRIGA Reactor: Facility Operating License No. R-84 AGENCY: Nuclear Regulatory Commission... considering an application for the renewal of Facility Operating License No. R-84 (Application), which... the renewal of Facility Operating License No. R-84, which currently authorizes the licensee to operate...

  6. Assessment of variable application rates of biological amendment ...

    African Journals Online (AJOL)

    Assessment of variable application rates of biological amendment substances on establishment and growth characteristics of maize plants. ... Hence, a greenhouse experiment was conducted in 2008 to assess the effects of variable rates (50, 75 and 100% of the recommended rates) of industrial manufactured biological ...

  7. Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study.

    Science.gov (United States)

    Lebov, Jill F; Engel, Lawrence S; Richardson, David; Hogan, Susan L; Hoppin, Jane A; Sandler, Dale P

    2016-01-01

    Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 39 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina. Via linkage to the US Renal Data System, we identified 320 ESRD cases diagnosed between enrolment (1993-1997) and December 2011 among 55 580 male licensed pesticide applicators. Participants provided information on use of pesticides via self-administered questionnaires. Lifetime pesticide use was defined as the product of duration and frequency of use and then modified by an intensity factor to account for differences in pesticide application practices. Cox proportional hazards models, adjusted for age and state, were used to estimate associations between ESRD and: (1) ordinal categories of intensity-weighted lifetime use of 39 pesticides, (2) poisoning and high-level pesticide exposures and (3) pesticide exposure resulting in a medical visit or hospitalisation. Positive exposure-response trends were observed for the herbicides alachlor, atrazine, metolachlor, paraquat, and pendimethalin, and the insecticide permethrin. More than one medical visit due to pesticide use (HR=2.13; 95% CI 1.17 to 3.89) and hospitalisation due to pesticide use (HR=3.05; 95% CI 1.67 to 5.58) were significantly associated with ESRD. Our findings support an association between ESRD and chronic exposure to specific pesticides, and suggest pesticide exposures resulting in medical visits may increase the risk of ESRD. Clinicaltrials.gov NCT00352924. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  8. 47 CFR 97.21 - Application for a modified or renewed license grant.

    Science.gov (United States)

    2010-10-01

    ... name, club name, license trustee name or license custodian name in accordance with § 1.913 of this... form to a Club Station Call Sign Administrator who must submit the information thereon to the FCC in an electronic batch file. The Club Station Call Sign Administrator must retain the collected information for at...

  9. Model tracking system for low-level radioactive waste disposal facilities: License application interrogatories and responses

    Energy Technology Data Exchange (ETDEWEB)

    Benbennick, M.E.; Broton, M.S.; Fuoto, J.S.; Novgrod, R.L.

    1994-08-01

    This report describes a model tracking system for a low-level radioactive waste (LLW) disposal facility license application. In particular, the model tracks interrogatories (questions, requests for information, comments) and responses. A set of requirements and desired features for the model tracking system was developed, including required structure and computer screens. Nine tracking systems were then reviewed against the model system requirements and only two were found to meet all requirements. Using Kepner-Tregoe decision analysis, a model tracking system was selected.

  10. Model tracking system for low-level radioactive waste disposal facilities: License application interrogatories and responses

    International Nuclear Information System (INIS)

    Benbennick, M.E.; Broton, M.S.; Fuoto, J.S.; Novgrod, R.L.

    1994-08-01

    This report describes a model tracking system for a low-level radioactive waste (LLW) disposal facility license application. In particular, the model tracks interrogatories (questions, requests for information, comments) and responses. A set of requirements and desired features for the model tracking system was developed, including required structure and computer screens. Nine tracking systems were then reviewed against the model system requirements and only two were found to meet all requirements. Using Kepner-Tregoe decision analysis, a model tracking system was selected

  11. Application of Quantum Dots in Biological Imaging

    Directory of Open Access Journals (Sweden)

    Shan Jin

    2011-01-01

    Full Text Available Quantum dots (QDs are a group of semiconducting nanomaterials with unique optical and electronic properties. They have distinct advantages over traditional fluorescent organic dyes in chemical and biological studies in terms of tunable emission spectra, signal brightness, photostability, and so forth. Currently, the major type of QDs is the heavy metal-containing II-IV, IV-VI, or III-V QDs. Silicon QDs and conjugated polymer dots have also been developed in order to lower the potential toxicity of the fluorescent probes for biological applications. Aqueous solubility is the common problem for all types of QDs when they are employed in the biological researches, such as in vitro and in vivo imaging. To circumvent this problem, ligand exchange and polymer coating are proven to be effective, besides synthesizing QDs in aqueous solutions directly. However, toxicity is another big concern especially for in vivo studies. Ligand protection and core/shell structure can partly solve this problem. With the rapid development of QDs research, new elements and new morphologies have been introduced to this area to fabricate more safe and efficient QDs for biological applications.

  12. 47 CFR 22.228 - Cellular rural service area licenses subject to competitive bidding.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Cellular rural service area licenses subject to... Procedures § 22.228 Cellular rural service area licenses subject to competitive bidding. Mutually exclusive initial applications for Cellular Rural Service Area licenses are subject to competitive bidding. The...

  13. BWR containments license renewal industry report; revision 1. Final report

    International Nuclear Information System (INIS)

    Smith, S.; Gregor, F.

    1994-07-01

    The U.S. nuclear power industry, through coordination by the Nuclear Management and Resources Council (NUMARC), and sponsorship by the U.S. Department of Energy (DOE) and the Electric Power Research Institute (EPRI), has evaluated age-related degradation effects for a number of major plant systems, structures, and components, in the license renewal technical Industry Reports (IR's). License renewal applicants may choose to reference these IR's in support of their plant-specific license renewal applications as an equivalent to the integrated plant assessment provisions of the license renewal rule (IOCFR54). The scope of the IR provides the technical basis for license renewal for U.S. Boiling Water Reactor (BWR) containments. The scope of the report includes containments constructed of reinforced or prestressed concrete with steel liners and freestanding stell containments. Those domestic BWR containments designated as Mark I, Mark II or Mark III are covered, but no containments are addressed before these designs. The report includes those items within the jurisdictional boundaries for metal and concrete containments defined by Section III of the ASME Boiler and Pressure Vessel Code, Division 1, Subsection NE (Class MC) and Division 2 (Class CC) and their supports, but excluding snubbers

  14. 10 CFR 780.34 - Criteria for decision to issue a license.

    Science.gov (United States)

    2010-01-01

    ... license. A license shall issue to the applicant to use the invention covered by the patent declared to be affected with the public interest pursuant to subsection 153b(2) of the Act upon a final decision that: (a...

  15. iBiology: communicating the process of science.

    Science.gov (United States)

    Goodwin, Sarah S

    2014-08-01

    The Internet hosts an abundance of science video resources aimed at communicating scientific knowledge, including webinars, massive open online courses, and TED talks. Although these videos are efficient at disseminating information for diverse types of users, they often do not demonstrate the process of doing science, the excitement of scientific discovery, or how new scientific knowledge is developed. iBiology (www.ibiology.org), a project that creates open-access science videos about biology research and science-related topics, seeks to fill this need by producing videos by science leaders that make their ideas, stories, and experiences available to anyone with an Internet connection. © 2014 Goodwin. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  16. Economic implications of nuclear plant license renewal in the U.S

    International Nuclear Information System (INIS)

    Smith, L.J.

    2001-01-01

    The NRC and the nuclear industry struggled for many years with the development of a viable license renewal rule. Now that a workable rule appears to have been developed, and the first license renewal applicants have received renewed licenses, the floodgates have opened and a large number of nuclear utilities have announced intentions to seek renewed NRC operating licenses. In this time when profound changes are being experienced in the electric generation markets in the United States, nuclear plant license renewal can have several economic effects that should be considered by utilities prior to the pursuit of an NRC license renewal. This paper examines some of the factors that may be affected by the prospect of an additional 20-year operating life of a nuclear plant. (author)

  17. 78 FR 69852 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2013-11-21

    .... dba Freight Team dba iGlobal US (NVO & OFF), 15930 Valley Boulevard, City of Industry, CA 91744.... Amexlog Corporation dba Amex Logistics Corp (NVO & OFF), 1970 NW 70th Avenue, Miami, FL 33126. Officers... License. Canfleet Logistics Ltd. (NVO), 1408-700 West Pender Street, Vancouver, B.C. V6C 1G8. Officers...

  18. [Applications of synthetic biology in materials science].

    Science.gov (United States)

    Zhao, Tianxin; Zhong, Chao

    2017-03-25

    Materials are the basis for human being survival and social development. To keep abreast with the increasing needs from all aspects of human society, there are huge needs in the development of advanced materials as well as high-efficiency but low-cost manufacturing strategies that are both sustainable and tunable. Synthetic biology, a new engineering principle taking gene regulation and engineering design as the core, greatly promotes the development of life sciences. This discipline has also contributed to the development of material sciences and will continuously bring new ideas to future new material design. In this paper, we review recent advances in applications of synthetic biology in material sciences, with the focus on how synthetic biology could enable synthesis of new polymeric biomaterials and inorganic materials, phage display and directed evolution of proteins relevant to materials development, living functional materials, engineered bacteria-regulated artificial photosynthesis system as well as applications of gene circuits for material sciences.

  19. Biological isotopy. Introduction to the isotopic effects and to their applications in biology

    International Nuclear Information System (INIS)

    Tcherkez, G.

    2010-01-01

    Since their discovery in the beginning of the 20. century, the study of stable isotopes has considerably developed. This domain, which remained limited in its applications until the 1990's, has become particularly important thereafter thanks to its practical applications and in particular to its economical impacts. Many techniques used in fraud control, in drugs use control, in selection of high-yield plants etc are based on isotopic abundance measurements. This reference book gives a synthesis of our actual knowledge on the use of stable isotopes and of isotope fractionation in biology. It presents the basic notions of isotopic biochemistry and explains the origin of the isotopic effects. The application principles of these effects to metabolism, to organisms physiology, to environmental biology etc are explained and detailed using examples and exercises. The first chapters present the basic knowledge which defines, from a mathematical point-of-view, the isotopic effects of chemical reactions or of physical processes taking place in biology. The measurements principle of natural isotopes abundance is then synthesised. Finally, all these notions are applied at different scales: enzymes, physiology, metabolism, environment, ecosystems and fraud crackdown. (J.S.)

  20. Licensing of ANSTO's Replacement Research Reactor

    International Nuclear Information System (INIS)

    Summerfield, M.W.; Garea, V.

    2003-01-01

    This paper presents a general description of the licensing of the 20 MW Pool-type Replacement Research Reactor (RRR) currently being built by the Australian Nuclear Science and Technology Organisation (ANSTO) at their Lucas Heights site. The following aspects will be addressed: 1) The influence of ARPANSA's (the Australian regulator) Regulatory Assessment Principles and Design Criteria on the design of the RRR. 2) The Site Licence Application, including the EIS and the supporting siting documentation. 3) The Construction Licence Application, including the PSAR and associated documentation. 4) The review process, including the IAEA Peer Review and the Public Submissions as well as ARPANSA's own review. 5) The interface between ANSTO, INVAP and ARPANSA in relation to the ongoing compliance with ARPANS Regulation 51 and 54. 6) The future Operating Licence Application, including the draft FSAR and associated documentation. These aspects are all addressed from the point of view of the licensee ANSTO and the RRR Project. Particular emphasis will be given to the way in which the licensing process is integrated into the overall project program and how the licensing and regulatory regime within Australia influenced the design of the RRR. In particular, the safety design features that have been incorporated as a result of the specific requirements of ANSTO and the Australian regulator will be briefly described. The paper will close with a description of how the RRR meets, and in many aspects exceeds the requirements of ANSTO and the Australian regulator. (author)

  1. A new license plate extraction framework based on fast mean shift

    Science.gov (United States)

    Pan, Luning; Li, Shuguang

    2010-08-01

    License plate extraction is considered to be the most crucial step of Automatic license plate recognition (ALPR) system. In this paper, a region-based license plate hybrid detection method is proposed to solve practical problems under complex background in which existing large quantity of disturbing information. In this method, coarse license plate location is carried out firstly to get the head part of a vehicle. Then a new Fast Mean Shift method based on random sampling of Kernel Density Estimate (KDE) is adopted to segment the color vehicle images, in order to get candidate license plate regions. The remarkable speed-up it brings makes Mean Shift segmentation more suitable for this application. Feature extraction and classification is used to accurately separate license plate from other candidate regions. At last, tilted license plate regulation is used for future recognition steps.

  2. Conditions for licensing workers exposed to ionizing radiation

    International Nuclear Information System (INIS)

    2007-01-01

    This entrance speaking on conditions of license workers in the areas of employment ionizing radiation addresses two aspects, the first aspect: industrial applications: speak for the workers in this area by a supervisor to portray industrial and industrial photographer and a supervisor sounding wells and a Nuclear Gauges Supervisor and the previous and subsequent Practices of the law The second aspect: about the medical applications and describes the general conditions of the licenses in this area and those working in this area of professional diagnostic radiology and nuclear medicine technician and technician treatment of radiotherapy and radiation protection officers at large and small institutions

  3. Applicability of IBAMA normative instruction 146-2007 to pipeline environmental licensing

    Energy Technology Data Exchange (ETDEWEB)

    Basbaum, Marcos A.; Fonseca, Renata A.A. [Servicos de Engenharia Emilio Baumgart Ltda. (SEEBLA), Rio de Janeiro, RJ(Brazil)], e-mail: mbasbaum.seebla@petrobras.com.br, e-mail: renataamorim.seebla@petrobras.com.br; Torggler, Bianca F.; Fernandes, Renato; Guimaraes, Ricardo Z.P. [Petroleo do Brasil S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)], e-mail: torggler@petrobras.com.br, e-mail: renatofer@petrobras.com.br, e-mail: rzaluar@petrobras.com.br

    2009-07-01

    PETROBRAS has been conducting several wildlife programs in response to environmental licensing requirements from IBAMA (Brazilian environmental agency). Since 2007, IBAMA has been requiring the application of the Normative Instruction n. 146 (NI), which establishes criteria for wildlife management in the influence areas of new enterprises. However, experience from PETROBRAS has shown that many of the NI articles are not applicable to pipelines. Thus, a critical analysis of this NI was done based on data from company's wildlife programs. Our analysis indicated that the main NI items that do not apply to pipelines are: 1 - Animal rescue programs in deforested areas and selection of release areas, 2 - More than two fauna monitoring campaigns a year, 3 - Monitoring programs involving all groups of terrestrial vertebrates and also invertebrate classes. The non-applicability of these items is due to: 1 - The majority of pipelines are built in areas without significant native vegetation or with small fragments only, which are usually in secondary stage of ecological succession. Most pipelines scarcely involve removal of primary vegetation, 2 - Pipelines have an influence area restricted to a range of 800 m and the construction directly affects only strips from 20 m to 30 m, 3 - The most relevant impacts associated with pipelines are temporary, and do not persist during their operation. (author)

  4. Licensing systems and inspection of nuclear installations in NEA Member countries. Part 1, Description of licensing systems

    International Nuclear Information System (INIS)

    1977-01-01

    This study provides an assessment of the legislative and regulatory provisions applicable and of the practices followed in the countries concerned and is divided into two separate sections. This document is the first part only. It contains the description of national licensing and inspection systems for nuclear installations in the twenty OECD countries which have specific regulations in this field. Each analysis has been presented following a plan which is as standardised as possible so as to facilitate comparison between the national systems. Part II, which is not included in this document, contains the diagrams illustrating the steps in the licensing procedure and the duties of the bodies involved as well as certain additional documents. It also includes a table showing the sequence of the main steps in the licensing process in the countries covered by this Study

  5. 77 FR 34392 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2012-06-11

    ... pneumonia viruses, and other viral infections. Potential Commercial Applications: Prevention and treatment... of federally-funded research and development. Foreign patent applications are filed on selected... INFORMATION: Licensing information and copies of the U.S. patent applications listed below may be obtained by...

  6. Biological applications of novel nonlinear optical microscopy

    International Nuclear Information System (INIS)

    Kajiyama, Shin'ichiro; Ozeki, Yasuyuki; Itoh, Kazuyoshi; Fukui, Kiichi

    2010-01-01

    Two types of newly developed nonlinear optical microscopes namely stimulated parametric emission (SPE) microscope and stimulated Raman scattering (SRS) microscope were presented together with their biological applications.

  7. Licensing procedures for Low-Level Waste disposal facilities

    Energy Technology Data Exchange (ETDEWEB)

    Roop, R.D.; Van Dyke, J.W.

    1985-09-01

    This report describes the procedures applicable to siting and licensing of disposal facilities for low-level radioactive wastes. Primary emphasis is placed on those procedures which are required by regulations, but to the extent possible, non-mandatory activities which will facilitate siting and licensing are also considered. The report provides an overview of how the procedural and technical requirements for a low-level waste (LLW) disposal facility (as defined by the Nuclear Regulatory Commission's Rules 10 CFR Parts 2, 51, and 61) may be integrated with activities to reduce and resolve conflict generated by the proposed siting of a facility. General procedures are described for site screening and selection, site characterization, site evaluation, and preparation of the license application; specific procedures for several individual states are discussed. The report also examines the steps involved in the formal licensing process, including docketing and initial processing, preparation of an environmental impact statement, technical review, hearings, and decisions. It is concluded that development of effective communication between parties in conflict and the utilization of techniques to manage and resolve conflicts represent perhaps the most significant challenge for the people involved in LLW disposal in the next decade. 18 refs., 6 figs.

  8. The use of U.S. NRC licensing practices for VVERs

    International Nuclear Information System (INIS)

    Popp, D.M.

    2000-01-01

    The licensing process for the upgraded Temelin I and C and Fuel designs were enhanced with the introduction of U.S. Nuclear Regulatory Commission, NRC practices. Specifically, the use of the NRC Regulatory Guide 1.70, 'Standard Format and Content Guide for Safety Analyses Reports' and NRC NUREG 0800, 'Standard Review Plan for the Review of Safety Analysis Reports for Nuclear Power Plants', were beneficial in the development and review of Temelin licensing documentation. These standards have been used for the preparation and review of Safety Analysis Reports in the United States and also in a large number of licensing applications around the world. Both Regulatory Guide 1.70 and NUREG 0800 were developed to provide a predictable and structured approach to licensing. This paper discusses this approach and identifies the benefits to designers, writers of licensing documentation and reviewers of licensing documents. (author)

  9. Biological applications of ultraviolet free-electron lasers

    International Nuclear Information System (INIS)

    Sutherland, J.C.

    1997-10-01

    This review examines the possibilities for biological research using the three ultraviolet free-electron lasers that are nearing operational status in the US. The projected operating characteristics of major interest in biological research of the free-electron lasers at Brookhaven National Laboratory, the Thomas Jefferson National Accelerator Facility, and Duke University are presented. Experimental applications in the areas of far- and vacuum ultraviolet photophysics and photochemistry, structural biology, environmental photobiology, and medical research are discussed and the prospects for advances in these areas, based upon the characteristics of the new ultraviolet free-electron lasers, are evaluated

  10. Chemiluminescence. Principles and applications in biology and medicine

    Energy Technology Data Exchange (ETDEWEB)

    Campbell, A K

    1988-01-01

    Chemiluminescence, the emission of light caused by a chemical reaction, is a phenomenon used for many applications and of wide biological importance. It occurs in bacteria and insects (including glow-worms and fireflies), in many of the animals in the deep sea and even in human cells. The last 25 years have witnessed fast progress in the elucidation of the reactions and mechanisms underlying bioluminescence and light production by synthetic systems. Together with the development of highly sensitive light detectors, this has made available new biomedical methods and has given rise to new concepts concerning the biology and pathology of the cell. The book describes the occurrence, chemistry and measurement of chemiluminescence. It deals with the biological function and evolutionary significance, and looks at the many biomedical applications. The author describes the uses of chemiluminescence to measure enzymes, substrates and metabolites, to detect the changes of calcium concentration in living cells, to determine oxygen radicals or to replace the radioactive labels in immunoassays. Future applications in research and clinical laboratories are also discussed.

  11. Photoluminescent ZnO Nanoparticles and Their Biological Applications

    Directory of Open Access Journals (Sweden)

    Zheng-Yong Zhang

    2015-05-01

    Full Text Available During the past decades, numerous achievements concerning luminescent zinc oxide nanoparticles (ZnO NPs have been reported due to their improved luminescence and good biocompatibility. The photoluminescence of ZnO NPs usually contains two parts, the exciton-related ultraviolet (UV emission and the defect-related visible emission. With respect to the visible emission, many routes have been developed to synthesize and functionalize ZnO NPs for the applications in detecting metal ions and biomolecules, biological fluorescence imaging, nonlinear multiphoton imaging, and fluorescence lifetime imaging. As the biological applications of ZnO NPs develop rapidly, the toxicity of ZnO NPs has attracted more and more attention because ZnO can produce the reactive oxygen species (ROS and release Zn2+ ions. Just as a coin has two sides, both the drug delivery and the antibacterial effects of ZnO NPs become attractive at the same time. Hence, in this review, we will focus on the progress in the synthetic methods, luminescent properties, and biological applications of ZnO NPs.

  12. Use of modeling in repository licensing

    International Nuclear Information System (INIS)

    McGarry, J.M. III; Echols, F.S.

    1995-01-01

    A review of the regulatory history of the Nuclear Regulatory Commission (NRC) regulations applicable to the licensing of a geologic repository, as well as a review of NRC administrative (licensing) decisions and federal case law, support the NRC's use of simplified models, in appropriate circumstances, which provide well-documented and reasonably conservative bounding assumptions, together with the use of expert judgement, natural analogues, and other aids to supplement available information, in reaching its reasonable assurance determination whether the public health and safety will be adequately protected if the Yucca Mountain, Nevada site should be licensed for development as a geologic repository. Specific examples are provided to assist the reader to better understand how such qualitative concepts as open-quote reasonable assurance close-quote, open-quote reasonably conservative close-quote, and open-quote adequate close-quote protection are used in an administrative context to resolve technical issues

  13. Demonstrating safety during license renewal should not be a large task

    International Nuclear Information System (INIS)

    Berto, D.S.

    1993-01-01

    The principal regulatory goal related to nuclear power plant operation is to ensure the health and safety of the public. The principal goal of extended plant operation via the license renewal process is also to ensure the health and safety of the public. The license renewal documentation issued by the Nuclear Regulatory Commission (NRC) provides guidance on what will be acceptable to the NRC in a license renewal application to demonstrate that this goal will be met. Application of this guidance is currently open to wide interpretation, with many of the current approaches proving to be extremely costly, complex, and uncertain of acceptability. This paper evaluates the requirements necessary to ensure the continued health and safety of the public during any license renewal term. This evaluation is based on the stated goals of the License Renewal Rule and on the published bases for the Rule. An approach to License Renewal is recommended that: (1) meets the stated goals of the NRC; (2) is consistent with current regulatory practices; and (3) will continue to ensure the health and safety of the public. This recommended approach is also much less costly than other current approaches, and can be easily agreed to by all participants. This approach will meet regulatory goals, while removing the cost and uncertainty obstacles currently being confronted by utilities. Providing a viable approach to license renewal will allow the renewal process to be pursued by utilities. Without such an approach, safe and reliable nuclear power plants will be permanently shut down at the arbitrary 40 year license limit

  14. Structural Biology: Practical NMR Applications

    CERN Document Server

    Teng, Quincy

    2005-01-01

    This textbook begins with an overview of NMR development and applications in biological systems. It describes recent developments in instrument hardware and methodology. Chapters highlight the scope and limitation of NMR methods. While detailed math and quantum mechanics dealing with NMR theory have been addressed in several well-known NMR volumes, chapter two of this volume illustrates the fundamental principles and concepts of NMR spectroscopy in a more descriptive manner. Topics such as instrument setup, data acquisition, and data processing using a variety of offline software are discussed. Chapters further discuss several routine stategies for preparing samples, especially for macromolecules and complexes. The target market for such a volume includes researchers in the field of biochemistry, chemistry, structural biology and biophysics.

  15. The Swedish radiological environmental protection regulations applied in a review of a license application for a geological repository for spent nuclear fuel.

    Science.gov (United States)

    Andersson, Pål; Stark, Karolina; Xu, Shulan; Nordén, Maria; Dverstorp, Björn

    2017-11-01

    For the first time, a system for specific consideration of radiological environmental protection has been applied in a major license application in Sweden. In 2011 the Swedish Nuclear Fuel & Waste Management Co. (SKB) submitted a license application for construction of a geological repository for spent nuclear fuel at the Forsmark site. The license application is supported by a post-closure safety assessment, which in accordance with regulatory requirements includes an assessment of environmental consequences. SKB's environmental risk assessment uses the freely available ERICA Tool. Environmental media activity concentrations needed as input to the tool are calculated by means of complex biosphere modelling based on site-specific information gathered from site investigations, as well as from supporting modelling studies and projections of future biosphere conditions in response to climate change and land rise due to glacial rebound. SKB's application is currently being reviewed by the Swedish Radiation Safety Authority (SSM). In addition to a traditional document review with an aim to determine whether SKB's models are relevant, correctly implemented and adequately parametrized, SSM has performed independent modelling in order to gain confidence in the robustness of SKB's assessment. Thus, SSM has used alternative stylized reference biosphere models to calculate environmental activity concentrations for use in subsequent exposure calculations. Secondly, an alternative dose model (RESRAD-BIOTA) is used to calculate doses to biota that are compared with SKB's calculations with the ERICA tool. SSM's experience from this review is that existing tools for environmental dose assessment are possible to use in order to show compliance with Swedish legislation. However, care is needed when site representative species are assessed with the aim to contrast them to generic reference organism. The alternative modelling of environmental concentrations resulted in much lower

  16. 18 CFR 4.106 - Standard terms and conditions of case-specific exemption from licensing.

    Science.gov (United States)

    2010-04-01

    ... LICENSES, PERMITS, EXEMPTIONS, AND DETERMINATION OF PROJECT COSTS Exemption of Small Hydroelectric Power... licensing. Any case-specific exemption from licensing granted for a small hydroelectric power project is... falsehoods were made by or on behalf of the applicant. (h) Article 8. Any exempted small hydroelectric power...

  17. Functionalized Nanodiamonds for Biological and Medical Applications.

    Science.gov (United States)

    Lai, Lin; Barnard, Amanda S

    2015-02-01

    Nanodiamond is a promising material for biological and medical applications, owning to its relatively inexpensive and large-scale synthesis, unique structure, and superior optical properties. However, most biomedical applications, such as drug delivery and bio-imaging, are dependent upon the precise control of the surfaces, and can be significantly affected by the type, distribution and stability of chemical funtionalisations of the nanodiamond surface. In this paper, recent studies on nanodiamonds and their biomedical applications by conjugating with different chemicals are reviewed, while highlighting the critical importance of surface chemical states for various applications.

  18. Automation of the DoD Export License Application Review Process

    National Research Council Canada - National Science Library

    Young, Shelton

    2002-01-01

    .... The overall audit objective was to determine whether Federal automation programs supporting the export license and review process could be used to establish a common electronic interface creating...

  19. TinkerCell: modular CAD tool for synthetic biology

    Science.gov (United States)

    Chandran, Deepak; Bergmann, Frank T; Sauro, Herbert M

    2009-01-01

    Background Synthetic biology brings together concepts and techniques from engineering and biology. In this field, computer-aided design (CAD) is necessary in order to bridge the gap between computational modeling and biological data. Using a CAD application, it would be possible to construct models using available biological "parts" and directly generate the DNA sequence that represents the model, thus increasing the efficiency of design and construction of synthetic networks. Results An application named TinkerCell has been developed in order to serve as a CAD tool for synthetic biology. TinkerCell is a visual modeling tool that supports a hierarchy of biological parts. Each part in this hierarchy consists of a set of attributes that define the part, such as sequence or rate constants. Models that are constructed using these parts can be analyzed using various third-party C and Python programs that are hosted by TinkerCell via an extensive C and Python application programming interface (API). TinkerCell supports the notion of a module, which are networks with interfaces. Such modules can be connected to each other, forming larger modular networks. TinkerCell is a free and open-source project under the Berkeley Software Distribution license. Downloads, documentation, and tutorials are available at . Conclusion An ideal CAD application for engineering biological systems would provide features such as: building and simulating networks, analyzing robustness of networks, and searching databases for components that meet the design criteria. At the current state of synthetic biology, there are no established methods for measuring robustness or identifying components that fit a design. The same is true for databases of biological parts. TinkerCell's flexible modeling framework allows it to cope with changes in the field. Such changes may involve the way parts are characterized or the way synthetic networks are modeled and analyzed computationally. TinkerCell can readily

  20. TinkerCell: modular CAD tool for synthetic biology

    Directory of Open Access Journals (Sweden)

    Bergmann Frank T

    2009-10-01

    Full Text Available Abstract Background Synthetic biology brings together concepts and techniques from engineering and biology. In this field, computer-aided design (CAD is necessary in order to bridge the gap between computational modeling and biological data. Using a CAD application, it would be possible to construct models using available biological "parts" and directly generate the DNA sequence that represents the model, thus increasing the efficiency of design and construction of synthetic networks. Results An application named TinkerCell has been developed in order to serve as a CAD tool for synthetic biology. TinkerCell is a visual modeling tool that supports a hierarchy of biological parts. Each part in this hierarchy consists of a set of attributes that define the part, such as sequence or rate constants. Models that are constructed using these parts can be analyzed using various third-party C and Python programs that are hosted by TinkerCell via an extensive C and Python application programming interface (API. TinkerCell supports the notion of a module, which are networks with interfaces. Such modules can be connected to each other, forming larger modular networks. TinkerCell is a free and open-source project under the Berkeley Software Distribution license. Downloads, documentation, and tutorials are available at http://www.tinkercell.com. Conclusion An ideal CAD application for engineering biological systems would provide features such as: building and simulating networks, analyzing robustness of networks, and searching databases for components that meet the design criteria. At the current state of synthetic biology, there are no established methods for measuring robustness or identifying components that fit a design. The same is true for databases of biological parts. TinkerCell's flexible modeling framework allows it to cope with changes in the field. Such changes may involve the way parts are characterized or the way synthetic networks are modeled

  1. Current regulatory and licensing status for byproduct sources, facilities and applications

    International Nuclear Information System (INIS)

    Tingey, G.L.; Jensen, G.A.; Hazelton, R.F.

    1985-02-01

    Public use of nuclear byproducts, especially radioactive isotopes, will require approval by various regulatory agencies. Use of cesium-137 as an irradiation source for sterilizing medical products will require US Nuclear Regulatory Commission (NRC) approval. Two applications have been filed with NRC, and approval is expected soon. Widespread use of irradiation for food products depends on a favorable ruling by the Food and Drug Administration (FDA). A ruling is pending that would permit irradiation of fruits and vegetables up to 100 krad. NRC also controls the use of isotopes in remote power generators, but little regulatory action has been required in recent years. Recent development of radioluminescent (RL) lighting for runway lights has led to interest by commercial manufacturers. At the present time, a license has been issued to at least one manufacturer for sale of tritium-powered runway lights. 28 refs., 1 fig

  2. Stochastic chemical kinetics theory and (mostly) systems biological applications

    CERN Document Server

    Érdi, Péter; Lente, Gabor

    2014-01-01

    This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.

  3. The end game must end before license renewal begins

    International Nuclear Information System (INIS)

    Allen, S.R.; Edwards, D.W.

    1995-01-01

    The quest for a process and strategy to achieve license renewal was begun in the mid-1980s with the view that renewal was an imperative. A major portion of the nation's future electric supply seemed to be at stake. For plants who were becoming noncompetitive because of annual capital recovery, license renewal also appeared as the means of survival. These two perceptions led to a third: License renewal should be sought immediately upon completion of the first 20 yr of operation. Although the basic engineering premise of license renewal remains sound, the perceptions regarding timing of an application may be incorrect. This paper suggests that a gauntlet of uncertainty exists for all plants. Further, it is most severe between the 20th and 30th years of operation. Thus, the competitive viability of the plant must be sustained for most of the initial term before license renewal can become a serious option

  4. Applications of dynamical systems in biology and medicine

    CERN Document Server

    Radunskaya, Ami

    2015-01-01

    This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control.  Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction.  Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation. .

  5. 9th International Conference on Practical Applications of Computational Biology and Bioinformatics

    CERN Document Server

    Rocha, Miguel; Fdez-Riverola, Florentino; Paz, Juan

    2015-01-01

    This proceedings presents recent practical applications of Computational Biology and  Bioinformatics. It contains the proceedings of the 9th International Conference on Practical Applications of Computational Biology & Bioinformatics held at University of Salamanca, Spain, at June 3rd-5th, 2015. The International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB) is an annual international meeting dedicated to emerging and challenging applied research in Bioinformatics and Computational Biology. Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis o...

  6. NRC licensing of uranium enrichment plants

    International Nuclear Information System (INIS)

    Moran, B.W.

    1991-01-01

    The US Nuclear Regulatory Commission (NRC) is preparing a rule making that establishes the licensing requirements for low-enriched uranium enrichment plants. Although implementation of this rule making is timed to correspond with receipt of a license application for the Louisiana Energy Services centrifuge enrichment plant, the rule making is applicable to all uranium enrichment technologies. If ownership of the US gaseous diffusion plants and/or atomic vapor laser isotope separation is transferred to a private or government corporation, these plants also would be licensable under the new rule making. The Safeguards Studies Department was tasked by the NRC to provide technical assistance in support of the rule making and guidance preparation process. The initial and primary effort of this task involved the characterization of the potential safeguards concerns associated with a commercial enrichment plant, and the licensing issues associated with these concerns. The primary safeguards considerations were identified as detection of the loss of special nuclear material, detection of unauthorized production of material of low strategic significance, and detection of production of uranium enriched to >10% 235 U. The primary safeguards concerns identified were (1) large absolute limit of error associated with the material balance closing, (2) the inability to shutdown some technologies to perform a cleanout inventory of the process system, and (3) the flexibility of some technologies to produce higher enrichments. Unauthorized production scenarios were identified for some technologies that could prevent conventional material control and accounting programs from detecting the production and removal of 5 kg 235 U as highly enriched uranium. Safeguards techniques were identified to mitigate these concerns

  7. The Atomic Energy Control Board requirements for the radioisotope licensing of a radiopharmaceutical facility

    International Nuclear Information System (INIS)

    Kennedy, P.

    1980-01-01

    Items that must be addressed by an applicant for a radioisotope license in Canada are described. Site, design and operating conditions, safety assessment, organization, emergency procedures and operating policies and procedures must be described to the Atomic Energy Control Board (AECB), in support of any license application. All information submitted in support of the application is subject to AECB's policy on public access to that information. (OT)

  8. The pre-licensing of a multi-purpose hybrid research reactor for high-tech applications 'MYRRHA'

    International Nuclear Information System (INIS)

    Hakimi, N.; Dams, C.; Wertelaers, A.; Nys, V.; Schrauben, M.; Dresselaers, R.

    2013-01-01

    The Belgian Nuclear Research Centre in Mol has been working for several years on the design of a multi-purpose flexible irradiation facility in order to replace the ageing BR2, a multipurpose materials testing reactor (MTR), in operation since 1962. MYRRHA, a flexible fast spectrum research reactor is conceived as an accelerator driven system (ADS), able to operate in sub-critical and critical modes. It contains a proton accelerator of 600 MeV, a spallation target and a multiplying medium with MOX fuel, cooled by liquid lead-bismuth (Pb-Bi). Since February 2011, the Belgian Nuclear Research Centre has engaged in a 'pre-licensing' process with the regulatory authority for an estimated period up to mid 2014. The paper presents on the one hand the objectives of the pre-licensing phase as well as its implementation process and on the other hand, 2 implementing instruments which have been developed by the regulatory authority providing guidance to the designer of MYRRHA in order to meet the pre-licensing phase objectives. The first instrument is a strategic note for the design and operation of MYRRHA where as the second instrument is a guidance document for the format and content of a design options and provisions file (DOPF). Both instruments have been developed taking into account that MYRRHA is an irradiation facility using a Generation IV nuclear power system's type technology (liquid metal cooled fast neutron reactor). The strategic note overview aims to cover the safety approach as well as the security requirements and safeguards obligation applicable to MYRRHA. In particular, in the strategic note, a specific attention has been paid in order to ensure that a safety, security and safeguards integrated approach will drive the development of the MYRRHA design. The safety approach focuses on the safety goals and the minimum safety objectives set by the regulatory authority for this innovative design. The DOPF overview presents its objectives and structure resuming

  9. Safety and licensing analyses for the Fort St. Vrain HTGR

    International Nuclear Information System (INIS)

    Ball, S.J.; Conklin, J.C.; Harrington, R.M.; Cleveland, J.C.; Clapp, N.E. Jr.

    1982-01-01

    The Oak Ridge National Laboratory (ORNL) safety analysis program for the HTGR includes development and verification of system response simulation codes, and applications of these codes to specific Fort St. Vrain reactor licensing problems. Licensing studies addressed the oscillation problems and the concerns about large thermal stresses in the core support blocks during a postulated accident

  10. The role the safety analysis report and other documents in the licensing procedure in the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Albrecht, E.; Ballhaus, S.

    1975-01-01

    Legal requirements for the licensing procedure, requirements for and preparation of licensing documents, authorities and experts participating in the licensing procedure, course of the atomic licensing procedure e.g. application for construction and operation, public hearing, site and concept license, partial licenses. (HP) [de

  11. Mixed-Methods Design in Biology Education Research: Approach and Uses.

    Science.gov (United States)

    Warfa, Abdi-Rizak M

    Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. © 2016 L. A.-R. M. Warfa. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  12. Licensing authority's control of radiation sources and nuclear materials in Brazil

    International Nuclear Information System (INIS)

    Binns, D.A.C.

    2002-01-01

    Full text: The Brazilian Nuclear Energy Commission is the national licensing authority and among its responsibilities is the control of nuclear materials and radiation sources. This control is carried out in three different ways: 1) Control of the import and export of nuclear materials and radiation sources. To be able to import or export any nuclear material or radiation source, the user has to have an explicit permission of the licensing authority. This is controlled by electronic means in which the user has to fill a special form found on the licensing authority's home page, where he has to fill in his name, license number, license number of his radiation protection officer and data of the material to be imported or exported. These data are checked with a data base that contains all the information of the licensed users and qualified personnel before authorization is emitted. The airport authorities have already installed x-ray machines to check all baggages entering or leaving the country. 2) Transport and transfer permit for radiation sources. In order to transport and/or transfer radiations sources and nuclear materials within the country, the user(s) have to submit an application to the licensing authority. The user(s) fill out an application form where he fills in his company's name, licensing I.D., radiation protection officer's name and I.D and identification of the sources involved. These information are checked with the licensing operations data before the operations is permitted. 3) Inspections and radiation monitoring systems. Routine and regulatory inspections are continuously carried out where the user's radiation sources and nuclear materials inventory are checked. Also the physical security and protection of these materials are verified. The installation of monitoring systems is an item that is being discussed with the airport authorities so as to increase the possibilities of detecting any illegal transport of these materials. (author)

  13. 47 CFR 25.148 - Licensing provisions for the Direct Broadcast Satellite Service.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Licensing provisions for the Direct Broadcast Satellite Service. 25.148 Section 25.148 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space Stations § 25.148...

  14. Magnetic nanoparticles as potential candidates for biomedical and biological applications.

    Science.gov (United States)

    Zeinali Sehrig, Fatemeh; Majidi, Sima; Nikzamir, Nasrin; Nikzamir, Nasim; Nikzamir, Mohammad; Akbarzadeh, Abolfazl

    2016-05-01

    Magnetic iron oxide nanoparticles have become the main candidates for biomedical and biological applications, and the application of small iron oxide nanoparticles in in vitro diagnostics has been practiced for about half a century. Magnetic nanoparticles (MNPs), in combination with an external magnetic field and/or magnetizable grafts, allow the delivery of particles to the chosen target area, fix them at the local site while the medication is released, and act locally. In this review, we focus mostly on the potential use of MNPs for biomedical and biotechnological applications, and the improvements made in using these nanoparticles (NPs) in biological applications.

  15. Shaping Biological Knowledge: Applications in Proteomics

    Directory of Open Access Journals (Sweden)

    R. Appel

    2006-04-01

    Full Text Available The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa and a hypothesis-driven (focus on whole bacterial proteomes approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  16. Shaping biological knowledge: applications in proteomics.

    Science.gov (United States)

    Lisacek, F; Chichester, C; Gonnet, P; Jaillet, O; Kappus, S; Nikitin, F; Roland, P; Rossier, G; Truong, L; Appel, R

    2004-01-01

    The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa) and a hypothesis-driven (focus on whole bacterial proteomes) approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  17. Conceptual Design of On-line Based Licensing Review and Assesment System of Nuclear Installations and Nuclear Materials ('PRIBEN')

    International Nuclear Information System (INIS)

    Melani, Ai; Chang, Soon Heung

    2008-01-01

    At the present Indonesia has no nuclear power plant in operation yet, although it is expected that the first nuclear power plant will be operated and commercially available in around the year of 2016 to 2017 in Muria Peninsula. There are only three research reactors, one nuclear fuel fabrication plant for research reactors, and one experimental fuel fabrication plant for nuclear power, one isotope production facility and some other research facilities. All the facility is under Nuclear Energy Regulatory Agency (BAPETEN) controlling through regulation, licensing and inspection. The organizations operation submits licensing application to BAPETEN before utilizing the facility. According to the regulation before BAPETEN give license they perform review and assessment for the utility application. Based on the review and assessment result, BAPETEN may stipulate, reject, delay or terminate the license. In anticipation of expansion of the nuclear program in Indonesia, BAPETEN should have an integrated and updated system for review and asses the licensing application. For this reason, an expert system for the review and asses the licensing application, so-called PRIBEN (Perizinan Reaktor, Instalasi dan Bahan Nuklir/Licensing of Reactor, Nuclear Installations and Nuclear Materials), is developed which runs on the online-based reality environment

  18. Molecular biology applications to infectious diseases diagnostic

    International Nuclear Information System (INIS)

    2001-01-01

    This project goes directed to the applications of the techniques of molecular biology in hepatitis virus.A great advance of these techniques it allows its application to the diagnose molecular and it becomes indispensable to have these fundamental tools in the field of the Health Public for the detection precocious, pursuit of the treatment, the one predicts and the evolution of the patient hepatitis bearing virus technical.Use of molecular biology to increase the handling and the control of the patients with hepatitis B and C and to detect an adult numbers of positive cases by means of the training and integration of all the countries participating.Implement the technique of PCR to identify the virus of the hepatitis B and C,implement quantification methods and genotipification for these virus

  19. 47 CFR 13.17 - Replacement license.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Replacement license. 13.17 Section 13.17 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.17 Replacement... request a replacement. The application must be accompanied by the required fee and submitted to the...

  20. Licensing topical report: interpretation of general design criteria for high-temperature gas-cooled reactors

    International Nuclear Information System (INIS)

    Orvis, D.D.; Raabe, P.H.

    1980-01-01

    This Licensing Topical Report presents a set of General Design Criteria (GDC) which is proposed for applicability to licensing of graphite-moderated, high-temperature gas-cooled reactors (HTGRs). Modifications as necessary to reflect HTGR characteristics and design practices have been made to the GDC derived for applicability to light-water-cooled reactors and presented in Appendix A of Part 50, Title 10, Code of Federal Regulations, including the Introduction, Definitions, and Criteria. It is concluded that the proposed set of GDC affords a better basis for design and licensing of HTGRs

  1. The application of biological motion research: biometrics, sport, and the military.

    Science.gov (United States)

    Steel, Kylie; Ellem, Eathan; Baxter, David

    2015-02-01

    The body of research that examines the perception of biological motion is extensive and explores the factors that are perceived from biological motion and how this information is processed. This research demonstrates that individuals are able to use relative (temporal and spatial) information from a person's movement to recognize factors, including gender, age, deception, emotion, intention, and action. The research also demonstrates that movement presents idiosyncratic properties that allow individual discrimination, thus providing the basis for significant exploration in the domain of biometrics and social signal processing. Medical forensics, safety garments, and victim selection domains also have provided a history of research on the perception of biological motion applications; however, a number of additional domains present opportunities for application that have not been explored in depth. Therefore, the purpose of this paper is to present an overview of the current applications of biological motion-based research and to propose a number of areas where biological motion research, specific to recognition, could be applied in the future.

  2. To License or Not to License Remanufacturing Business?

    Directory of Open Access Journals (Sweden)

    Zu-Jun Ma

    2018-01-01

    Full Text Available Many original equipment manufacturers (OEMs face the choice of whether to license an independent remanufacturer (IR to remanufacture their used products. In this paper, we develop closed-loop supply chain models with licensed and unlicensed remanufacturing operations to analyze the competition and cooperation between an OEM and an IR. The OEM sells new products and collects used products through trade-ins, while the IR intercepts the OEM’s cores to produce remanufactured products and sell them in the same market. We derive optimal decisions for each of the two types of firms in licensed and unlicensed remanufacturing scenarios and identify conditions under which the OEM and the IR would be most likely to cooperate with each other in implementing remanufacturing. The results show although it is beneficial for an OEM to license an IR to remanufacture its cores, it is not always necessary for an IR to accept OEM’s authorization. Moreover, we contrast the result for licensed remanufacturing scenario in the decentralized system with that in the centrally coordinated system to quantify potential inefficiency resulting from decentralization of decision making.

  3. Applications of thermal neutron scattering in biology, biochemistry and biophysics

    International Nuclear Information System (INIS)

    Worcester, D.L.

    1977-01-01

    Biological applications of thermal neutron scattering have increased rapidly in recent years. The following categories of biological research with thermal neutron scattering are presently identified: crystallography of biological molecules; neutron small-angle scattering of biological molecules in solution (these studies have already included numerous measurements of proteins, lippoproteins, viruses, ribosomal subunits and chromatin subunit particles); neutron small-angle diffraction and scattering from biological membranes and membrane components; and neutron quasielastic and inelastic scattering studies of the dynamic properties of biological molecules and materials. (author)

  4. Technology licensing in China

    DEFF Research Database (Denmark)

    Wang, Yuandi; Li-Ying, Jason; Chen, Jin

    2015-01-01

    We explore the landscape of technology licensing among Chinese entities in the period 2000–12, using a unique database on technological licensing from the State Intellectual Property Office of China. We find that: first, among Chinese licensee organizations, firms have dominated in terms...... of the number of licensed technologies; second, the geographical distribution of licensed technologies among the provinces has gradually reached a new quantitative balance; third, utility models are the most popular technologies to be licensed and the majority of technology licensing in China has been between...... Chinese entities, and most transactions have been local within provinces; and finally, Chinese firms have gradually in-licensed newer and newer technologies, but the technologies in-licensed from foreign sources are by no means state-of-the-art. We make several suggestions for innovation policy...

  5. Nebraska withdraws its intent to deny site license

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    The state of Nebraska has withdrawn its notice of intent to deny the US Ecology (USE) license application for the proposed low-level radioactive waste disposal site in Boyd County, near Butte, Neb. On October 4, after review of USE's August 27 submittal of a revision to the boundaries of the proposed site, a letter from the state's Department of Health (DOH) and Department of Environmental Quality (DEQ) to John. H. DeOld, the USE project manager for the Central Interstate Compact's proposed LLW site, noted that open-quotes...we are hereby withdrawing the Notice of Intent to Deny License as a moot, and will conduct a substantive review of the reconfigured site for compliance with the applicable regulations.close quotes

  6. Biological applications of graphene oxide

    International Nuclear Information System (INIS)

    Gürel, Hikmet Hakan; Salmankurt, Bahadır

    2016-01-01

    Graphene as a 2D material has unique chemical and electronic properties. Because of its unique physical, chemical, and electronic properties, its interesting shape and size make it a promising nanomaterial in many biological applications. However, the lower water-solubility and the irreversible aggregation due to the strong π-π stacking hinder the wide application of graphene nanosheets in biomedical field. Thus, graphene oxide (GO), one derivative of graphene, has been used more frequently in the biological system owing to its relatively higher water solubility and biocompatibility. Recently, it has been demonstrated that nanomaterials with different functional groups on the surface can be used to bind the drug molecules with high affinity. GO has different functional groups such as H, OH and O on its surface; it can be a potential candidate as a drug carrier. The interactions of biomolecules and graphene like structures are long-ranged and very weak. Development of new techniques is very desirable for design of bioelectronics sensors and devices. In this work, we present first-principles spin polarized calculations within density functional theory to calculate effects of charging on DNA/RNA nucleobases on graphene oxide. It is shown that how modify structural and electronic properties of nucleobases on graphene oxide by applied charging.

  7. Beware the tail that wags the dog: informal and formal models in biology.

    Science.gov (United States)

    Gunawardena, Jeremy

    2014-11-05

    Informal models have always been used in biology to guide thinking and devise experiments. In recent years, formal mathematical models have also been widely introduced. It is sometimes suggested that formal models are inherently superior to informal ones and that biology should develop along the lines of physics or economics by replacing the latter with the former. Here I suggest to the contrary that progress in biology requires a better integration of the formal with the informal. © 2014 Gunawardena. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  8. PWR reactor pressure vessel internals license renewal industry report; revision 1. Final report

    International Nuclear Information System (INIS)

    Schwirian, R.; Robison, G.

    1994-07-01

    The U.S. nuclear power industry, through coordination by the Nuclear Management and Resources Council (NUMARC), and sponsorship by the U.S. Department of Energy (DOE) and the Electric Power Research Institute (EPRI), has evaluated age-related degradation effects for a number of major plant systems, structures and components, in the license renewal technical Industry Reports (IRs). License renewal applicants may choose to reference these IRs in support of their plant-specific license renewal applications, as an equivalent to the integrated plant assessment provisions of the license renewal rule (10 CFR Part 54). Pressurized water reactor (PWR) reactor pressure vessel (RPV) internals designed by all three U.S. PWR nuclear steam supply system vendors have been evaluated relative to the effects of age-related degradation mechanisms; the capability of current design limits; inservice examination, testing, repair, refurbishment, and other programs to manage these effects; and the assurance that these internals can continue to perform their intended safety functions in the license renewal term. This industry report (IR), one of a series of ten, provides a generic technical basis for evaluation of PWR reactor pressure vessel internals for license renewal

  9. Environmental Standard Review Plan for the review of a license application for a low-level radioactive waste disposal facility: Environmental report

    International Nuclear Information System (INIS)

    1987-04-01

    The Environmental Standard Review Plan (ESRP) (NUREG-1300) provides guidance to staff reviewers in the Office of Nuclear Material Safety and Safeguards who perform environmental reviews of environmental reports prepared by applicants in support of license applications to construct and operate new low-level radioactive waste disposal facilities. The individual ESRPs that constitute this document identify the information considered necessary to conduct the review, the purpose and scope of the review, the analysis procedure and evaluation, the formal input to the environmental statement, and the references considered appropriate for each review. The ESRP is intended to ensure quality and uniformity of approach in individual reviews as well as compliance with the National Environmental Policy Act of 1969. In addition, the ESRP will make information about the environmental component of the licensing process more readily available and thereby will serve to improve the understanding of this process among the public, States and regional compacts, and the regulated community

  10. Preparing as an organization, to submit or to review a construction license application for a DGR of ILW and HLW in France. French National Case - Andra - Preparing to Submit Cigeo's Creation License Application

    International Nuclear Information System (INIS)

    Boissier, Fabrice; Labalette, T.; Leverd, Pascal C.; Voinis, Sylvie

    2014-01-01

    The reversible repository in a deep geological formation is the French reference solution for the long-term management of high-level and intermediate-level long-lived radioactive waste. Since the first French Act on nuclear waste management research (1991), Andra has carried out twenty years of conceptual and basic studies on the subject, leading in particular to the feasibility demonstration in 2005 and to the choice of the detailed reconnaissance zone (ZIRA) in 2010. Taking advantage from this work, Andra has now reached a new phase where the project is engaging in the design of the industrial installation named Cigeo. At this stage, the further development of the project implies that Andra undertakes a multiplicity of actions in order to successfully reach various external and internal key milestones. Of paramount importance is the careful articulation between the regulatory authorization and decision processes and the outcome of the industrial installation design phases. In 2006 was built a regulatory framework that plans a succession of step by step decisions stages: 2013: Public debate on reversibility, memory keeping, environmental and health survey modalities, dialogue with the local stakeholders to harmoniously define and plan the external infrastructures that have to be developed to support the construction and the operation of Cigeo (roads, railway tracks and terminal, power and water supplies, etc.). 2015: Creation license application and start of the regulatory review process (notably various plans of the installation, the description of the solution envisaged for the closure of the facility, the preliminary safety case (operational safety, long-term safety, protection against malevolent actions, management of incidental situations, preliminary acceptance criteria), environmental impact studies (health, salubrity, transports, human activities, nature, patrimonial aspects). 2016-2017: new parliamentary Act on the reversibility conditions of the

  11. What it took to get an NRC license for centralized incineration

    International Nuclear Information System (INIS)

    DiSalvo, R.; Zielenbach, W.

    1987-01-01

    In 1982, Battelle joined five other commercial generators of low level radioactive waste in conducting a study of the technical and economic feasibility and the licensability of a central facility for incinerating LLW. The project generated a license application to the USNRC and supporting documentation related to the safety and environmental impacts of the facility. After thorough review, the NRC has issued a Finding of No Significant Impact and the associated license authorization, which is the first of its kind for an incineration facility

  12. Licensing process for safety-critical software-based systems

    Energy Technology Data Exchange (ETDEWEB)

    Haapanen, P. [VTT Automation, Espoo (Finland); Korhonen, J. [VTT Electronics, Espoo (Finland); Pulkkinen, U. [VTT Automation, Espoo (Finland)

    2000-12-01

    System vendors nowadays propose software-based technology even for the most critical safety functions in nuclear power plants. Due to the nature of software faults and the way they cause system failures new methods are needed for the safety and reliability evaluation of these systems. In the research project 'Programmable automation systems in nuclear power plants (OHA)', financed together by the Radiation and Nuclear Safety Authority (STUK), the Ministry of Trade and Industry (KTM) and the Technical Research Centre of Finland (VTT), various safety assessment methods and tools for software based systems are developed and evaluated. As a part of the OHA-work a reference model for the licensing process for software-based safety automation systems is defined. The licensing process is defined as the set of interrelated activities whose purpose is to produce and assess evidence concerning the safety and reliability of the system/application to be licensed and to make the decision about the granting the construction and operation permissions based on this evidence. The parties of the licensing process are the authority, the licensee (the utility company), system vendors and their subcontractors and possible external independent assessors. The responsibility about the production of the evidence in first place lies at the licensee who in most cases rests heavily on the vendor expertise. The evaluation and gauging of the evidence is carried out by the authority (possibly using external experts), who also can acquire additional evidence by using their own (independent) methods and tools. Central issue in the licensing process is to combine the quality evidence about the system development process with the information acquired through tests, analyses and operational experience. The purpose of the licensing process described in this report is to act as a reference model both for the authority and the licensee when planning the licensing of individual applications

  13. Licensing process for safety-critical software-based systems

    International Nuclear Information System (INIS)

    Haapanen, P.; Korhonen, J.; Pulkkinen, U.

    2000-12-01

    System vendors nowadays propose software-based technology even for the most critical safety functions in nuclear power plants. Due to the nature of software faults and the way they cause system failures new methods are needed for the safety and reliability evaluation of these systems. In the research project 'Programmable automation systems in nuclear power plants (OHA)', financed together by the Radiation and Nuclear Safety Authority (STUK), the Ministry of Trade and Industry (KTM) and the Technical Research Centre of Finland (VTT), various safety assessment methods and tools for software based systems are developed and evaluated. As a part of the OHA-work a reference model for the licensing process for software-based safety automation systems is defined. The licensing process is defined as the set of interrelated activities whose purpose is to produce and assess evidence concerning the safety and reliability of the system/application to be licensed and to make the decision about the granting the construction and operation permissions based on this evidence. The parties of the licensing process are the authority, the licensee (the utility company), system vendors and their subcontractors and possible external independent assessors. The responsibility about the production of the evidence in first place lies at the licensee who in most cases rests heavily on the vendor expertise. The evaluation and gauging of the evidence is carried out by the authority (possibly using external experts), who also can acquire additional evidence by using their own (independent) methods and tools. Central issue in the licensing process is to combine the quality evidence about the system development process with the information acquired through tests, analyses and operational experience. The purpose of the licensing process described in this report is to act as a reference model both for the authority and the licensee when planning the licensing of individual applications. Many of the

  14. Licensing process characteristics of Small Modular Reactors and spent nuclear fuel repository

    Energy Technology Data Exchange (ETDEWEB)

    Söderholm, Kristiina, E-mail: kristiina.soderholm@fortum.com [Fortum Power (Finland); Tuunanen, Jari, E-mail: jari.tuunanen@fortum.com [Fortum Power (Finland); Amaba, Ben, E-mail: baamaba@us.ibm.com [IBM Complex Systems (United States); Bergqvist, Sofia, E-mail: sofia.bergqvist@se.ibm.com [IBM Rational Software (Sweden); Lusardi, Paul, E-mail: plusardi@nuscalepower.com [NuScale Power (United States)

    2014-09-15

    Highlights: • We examine the licensing process challenges of modular nuclear facilities. • We compare the features of Small Modular Reactors and spent nuclear fuel repository. • We present the need of nuclear licensing simplification. • Part of the licensing is proposed to be internationally applicable. • Systems engineering and requirements engineering benefits are presented. - Abstract: This paper aims to increase the understanding of the licensing processes characteristics of Small Modular Reactors (SMR) compared with licensing of spent nuclear fuel repository. The basis of the SMR licensing process development lies in licensing processes used in Finland, France, the UK, Canada and the USA. These countries have been selected for this study because of their various licensing processes and recent actions in the new NPP construction. Certain aspects of the aviation industry licensing process have also been studied and selected practices have been investigated as possibly suitable for use in nuclear licensing. Suitable features for SMR licensing are emphasized and suggested. The licensing features of the spent nuclear fuel deep repository along with similar features of SMR licensing are discussed. Since there are similar types of challenges of lengthy licensing time frames, as well as modular features to be taken into account in licensing, these two different nuclear industry fields can be compared. The main SMR features to take into account in licensing are: • Standardization of the design. • Modularity. • Mass production. • Serial construction. Modularity can be divided into two different categories: the first category is simply a single power plant unit constructed of independently engineered modules (e.g. construction process for Westinghouse AP-1000 NPP) and the second one a power plant composed of many reactor modules, which are manufactured in factories and installed as needed (e.g. NuScale Power SMR design). The deep underground repository

  15. Economics of license renewal in the U.S. - entergy's perspective

    International Nuclear Information System (INIS)

    Young, Garry G.

    2003-01-01

    License renewal of operating nuclear plants in the United States has become one of the most successful U.S. nuclear regulatory activities in the past few years. In 1995, the U.S. Nuclear Regulatory Commission (NRC) published a revised rule in 10 CFR Part 54 that provided the requirements for an operating nuclear plant to seek license renewal. At that time, many people believed that only a select few operating nuclear plants would pursue license renewal and that most plants would operate for no more than 40 years. By mid-2003, the owners of approximately 52% of the U.S. nuclear fleet of 103 operating nuclear plants have decided to pursue license renewal and more are expected to follow. This change in direction since 1995 can be attributed to the improving economics of U.S. nuclear power plant operation and to the improved regulatory process resulting from the 1995 revision to 10 CFR Part 54. In 2000, Entergy submitted a license renewal application for Arkansas Nuclear One, Unit 1 (ANO-1). This application was the third to be submitted to the NRC at a time when it was still unclear how successful the regulatory process might be. However, less than 17 months later, in June 2001, the NRC granted a renewed operating license for ANO-1 at a total cost of approximately $11 million. Due in part to the ANO-1 license renewal success, Entergy now has tentative plans to pursue license renewal for the entire fleet of operating nuclear power plants. Without license renewal, Entergy's current nuclear fleet capacity of approximately 9,000 MW(e) would begin to decline in 2012. With license renewal, Entergy's nuclear fleet capacity can remain in place until 2032. This projection does not include the expected improvements in capacity due to power uprate that is currently planned. The combination of power uprate and license renewal will add significant economic value to Entergy's nuclear fleet. One of the major factors in strong performance is capacity factor. In 1990, the average

  16. Micro and nanotechnology for biological and biomedical applications.

    Science.gov (United States)

    Lim, Chwee Teck; Han, Jongyoon; Guck, Jochen; Espinosa, Horacio

    2010-10-01

    This special issue contains some of the current state-of-the-art development and use of micro and nanotechnological tools, devices and techniques for both biological and biomedical research and applications. These include nanoparticles for bioimaging and biosensing, optical and biophotonic techniques for probing diseases at the nanoscale, micro and nano-fabricated tools for elucidating molecular mechanisms of mechanotransduction in cell and molecular biology and cell separation microdevices and techniques for isolating and enriching targeted cells for disease detection and diagnosis. Although some of these works are still at the research stage, there is no doubt that some of the important outcomes will eventually see actual biomedical applications in the not too distant future.

  17. 75 FR 3217 - J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License...

    Science.gov (United States)

    2010-01-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11392-009] J&T Hydro Company; H. Dean Brooks and W. Bruce Cox; Notice of Application for Transfer of License and Soliciting Comments and Motions To Intervene January 12, 2010. On October 30, 2009, J&T Hydro Company (transferor) and...

  18. Yeast synthetic biology toolbox and applications for biofuel production.

    Science.gov (United States)

    Tsai, Ching-Sung; Kwak, Suryang; Turner, Timothy L; Jin, Yong-Su

    2015-02-01

    Yeasts are efficient biofuel producers with numerous advantages outcompeting bacterial counterparts. While most synthetic biology tools have been developed and customized for bacteria especially for Escherichia coli, yeast synthetic biological tools have been exploited for improving yeast to produce fuels and chemicals from renewable biomass. Here we review the current status of synthetic biological tools and their applications for biofuel production, focusing on the model strain Saccharomyces cerevisiae We describe assembly techniques that have been developed for constructing genes, pathways, and genomes in yeast. Moreover, we discuss synthetic parts for allowing precise control of gene expression at both transcriptional and translational levels. Applications of these synthetic biological approaches have led to identification of effective gene targets that are responsible for desirable traits, such as cellulosic sugar utilization, advanced biofuel production, and enhanced tolerance against toxic products for biofuel production from renewable biomass. Although an array of synthetic biology tools and devices are available, we observed some gaps existing in tool development to achieve industrial utilization. Looking forward, future tool development should focus on industrial cultivation conditions utilizing industrial strains. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.

  19. Licensing Support Network: An Electronic Discovery System

    International Nuclear Information System (INIS)

    Gil, A. V.; Jensen, D.; McKinnon, B.

    2002-01-01

    The necessary authorization for the U. S. Department of Energy's (DOE) Office of Civilian Radioactive Waste Management (OCRWM) to submit a License Application (LA) is contingent upon the policy process defined in the Nuclear Waste Policy Act, as amended (NWPA), with some steps yet to occur. In spite of this uncertainty, the DOE must take prudent and appropriate action now, and over the next several years, to prepare for submittal of an application and to facilitate the U. S. Nuclear Regulatory Commission (NRC) review of this application, if the Yucca Mountain site is recommended and approved for repository development. One of these steps the DOE has taken involves working with the NRC's Advisory Review Panel to develop Licensing Support Network (LSN) requirements and guidelines. The NRC has made a prototype of the LSN web page available at www.LSNNET.gov. The OCRWM part of the LSN currently has an indefinite life cycle and may need to remain in existence until the repository is closed, which could be as long as 325 years

  20. Licensing of the OPAL reactor during construction and commissioning

    International Nuclear Information System (INIS)

    Summerfield, M.

    2007-01-01

    This paper presents a description of the licensing activities associated with the construction and commissioning of the Australian Nuclear Science and Technology Organisation's (ANSTO) OPAL reactor. It addresses the Construction Licence, the interface between ANSTO, INVAP (the contractor with responsibility for design and construction of the facility) and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA, the Australian nuclear regulator) during the construction of OPAL, specific licensing issues that have arisen during the construction and commissioning process, and the Operating Licence Application. Particular emphasis will be given to the way in which the licensing process is integrated into the overall project program and the lessons learnt that may be of benefit to other licensees and regulators

  1. 37 CFR 5.25 - Petition for retroactive license.

    Science.gov (United States)

    2010-07-01

    ... invention of a pending application and no petition under § 1.181 has been filed, a final rejection of the..., DEPARTMENT OF COMMERCE GENERAL SECRECY OF CERTAIN INVENTIONS AND LICENSES TO EXPORT AND FILE APPLICATIONS IN... be renewed. Failure to renew the petition within the set time period will result in a final denial of...

  2. Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

    Directory of Open Access Journals (Sweden)

    Ye-Rang Yun

    2010-01-01

    Full Text Available Fibroblast growth factors (FGFs that signal through FGF receptors (FGFRs regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MAP kinase pathway, PI3 kinase/AKT pathway, and PLCγ pathway, among which the RAS/MAP kinase pathway is known to be predominant. Several studies have recently implicated the in vitro biological functions of FGFs for tissue regeneration. However, to obtain optimal outcomes in vivo, it is important to enhance the half-life of FGFs and their biological stability. Future applications of FGFs are expected when the biological functions of FGFs are potentiated through the appropriate use of delivery systems and scaffolds. This review will introduce the biology and cellular functions of FGFs and deal with the biomaterials based delivery systems and their current applications for the regeneration of tissues, including skin, blood vessel, muscle, adipose, tendon/ligament, cartilage, bone, tooth, and nerve tissues.

  3. Image simulation for automatic license plate recognition

    Science.gov (United States)

    Bala, Raja; Zhao, Yonghui; Burry, Aaron; Kozitsky, Vladimir; Fillion, Claude; Saunders, Craig; Rodríguez-Serrano, José

    2012-01-01

    Automatic license plate recognition (ALPR) is an important capability for traffic surveillance applications, including toll monitoring and detection of different types of traffic violations. ALPR is a multi-stage process comprising plate localization, character segmentation, optical character recognition (OCR), and identification of originating jurisdiction (i.e. state or province). Training of an ALPR system for a new jurisdiction typically involves gathering vast amounts of license plate images and associated ground truth data, followed by iterative tuning and optimization of the ALPR algorithms. The substantial time and effort required to train and optimize the ALPR system can result in excessive operational cost and overhead. In this paper we propose a framework to create an artificial set of license plate images for accelerated training and optimization of ALPR algorithms. The framework comprises two steps: the synthesis of license plate images according to the design and layout for a jurisdiction of interest; and the modeling of imaging transformations and distortions typically encountered in the image capture process. Distortion parameters are estimated by measurements of real plate images. The simulation methodology is successfully demonstrated for training of OCR.

  4. Secure matching of Dutch car license plates

    NARCIS (Netherlands)

    Sunil, A.B.; Erkiny, Z.; Veugenyz, T.

    2016-01-01

    License plate matching plays an important role in applications like law enforcement, traffic management and road pricing, where the plate is first recognized and then compared to a database of authorized vehicle registration plates. Unfortunately, there are several privacy related issues that should

  5. International Conference on Recent Advances in Mathematical Biology, Analysis and Applications

    CERN Document Server

    Saleem, M; Srivastava, H; Khan, Mumtaz; Merajuddin, M

    2016-01-01

    The book contains recent developments and contemporary research in mathematical analysis and in its application to problems arising from the biological and physical sciences. The book is of interest to readers who wish to learn of new research in such topics as linear and nonlinear analysis, mathematical biology and ecology, dynamical systems, graph theory, variational analysis and inequalities, functional analysis, differential and difference equations, partial differential equations, approximation theory, and chaos. All papers were prepared by participants at the International Conference on Recent Advances in Mathematical Biology, Analysis and Applications (ICMBAA-2015) held during 4–6 June 2015 in Aligarh, India. A focal theme of the conference was the application of mathematics to the biological sciences and on current research in areas of theoretical mathematical analysis that can be used as sophisticated tools for the study of scientific problems. The conference provided researchers, academicians and ...

  6. Stochastic narrow escape in molecular and cellular biology analysis and applications

    CERN Document Server

    Holcman, David

    2015-01-01

    This book covers recent developments in the non-standard asymptotics of the mathematical narrow escape problem in stochastic theory, as well as applications of the narrow escape problem in cell biology. The first part of the book concentrates on mathematical methods, including advanced asymptotic methods in partial equations, and is aimed primarily at applied mathematicians and theoretical physicists who are interested in biological applications. The second part of the book is intended for computational biologists, theoretical chemists, biochemists, biophysicists, and physiologists. It includes a summary of output formulas from the mathematical portion of the book and concentrates on their applications in modeling specific problems in theoretical molecular and cellular biology. Critical biological processes, such as synaptic plasticity and transmission, activation of genes by transcription factors, or double-strained DNA break repair, are controlled by diffusion in structures that have both large and small sp...

  7. 10 CFR 32.61 - Ice detection devices containing strontium-90; requirements for license to manufacture or...

    Science.gov (United States)

    2010-01-01

    ...; requirements for license to manufacture or initially transfer. 32.61 Section 32.61 Energy NUCLEAR REGULATORY COMMISSION SPECIFIC DOMESTIC LICENSES TO MANUFACTURE OR TRANSFER CERTAIN ITEMS CONTAINING BYPRODUCT MATERIAL... manufacture or initially transfer. An application for a specific license to manufacture or initially transfer...

  8. The Math-Biology Values Instrument: Development of a Tool to Measure Life Science Majors' Task Values of Using Math in the Context of Biology.

    Science.gov (United States)

    Andrews, Sarah E; Runyon, Christopher; Aikens, Melissa L

    2017-01-01

    In response to calls to improve the quantitative training of undergraduate biology students, there have been increased efforts to better integrate math into biology curricula. One challenge of such efforts is negative student attitudes toward math, which are thought to be particularly prevalent among biology students. According to theory, students' personal values toward using math in a biological context will influence their achievement and behavioral outcomes, but a validated instrument is needed to determine this empirically. We developed the Math-Biology Values Instrument (MBVI), an 11-item college-level self--report instrument grounded in expectancy-value theory, to measure life science students' interest in using math to understand biology, the perceived usefulness of math to their life science career, and the cost of using math in biology courses. We used a process that integrates multiple forms of validity evidence to show that scores from the MBVI can be used as a valid measure of a student's value of math in the context of biology. The MBVI can be used by instructors and researchers to help identify instructional strategies that influence math-biology values and understand how math-biology values are related to students' achievement and decisions to pursue more advanced quantitative-based courses. © 2017 S. E. Andrews et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  9. Libraries and licensing

    Directory of Open Access Journals (Sweden)

    Maja Žumer

    2001-01-01

    Full Text Available In the mid 90s, the abundance of various electronic publications exposed libraries to the problems of licensing electronic content. Various licensing principles have been prepared recently to help libraries in the process; it can be said that in general, the knowledge of licensing issues has improved in libraries of all types. Libraries form consortia in order to gain stronger negotiating positions and obtain better conditions.In the article, new licensing principles are presented in more detail, as well as some domestic and foreign experiences with consortia forming.

  10. Synthetic biology platform technologies for antimicrobial applications.

    Science.gov (United States)

    Braff, Dana; Shis, David; Collins, James J

    2016-10-01

    The growing prevalence of antibiotic resistance calls for new approaches in the development of antimicrobial therapeutics. Likewise, improved diagnostic measures are essential in guiding the application of targeted therapies and preventing the evolution of therapeutic resistance. Discovery platforms are also needed to form new treatment strategies and identify novel antimicrobial agents. By applying engineering principles to molecular biology, synthetic biologists have developed platforms that improve upon, supplement, and will perhaps supplant traditional broad-spectrum antibiotics. Efforts in engineering bacteriophages and synthetic probiotics demonstrate targeted antimicrobial approaches that can be fine-tuned using synthetic biology-derived principles. Further, the development of paper-based, cell-free expression systems holds promise in promoting the clinical translation of molecular biology tools for diagnostic purposes. In this review, we highlight emerging synthetic biology platform technologies that are geared toward the generation of new antimicrobial therapies, diagnostics, and discovery channels. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. 75 FR 15419 - Notice of Intent To Grant Exclusive License of U.S. Patent Application No. 12/432,842 Filed April...

    Science.gov (United States)

    2010-03-29

    ... Exclusive License of U.S. Patent Application No. 12/432,842 Filed April 30, 2009 Entitled: ``A Soil Stabilization Soil Comprising Same, and a Method of Stabilizing Soil'' AGENCY: Department of the Army, U.S. Army... climates with sandy, gravelly soils where emulsions and hydraulic cements will not effectively cure. If...

  12. Considerations about the licensing process of special nuclear industrial facilities

    Energy Technology Data Exchange (ETDEWEB)

    Talarico, M.A., E-mail: talaricomarco@hotmail.com [Marinha do Brasil, Rio de Janeiro, RJ (Brazil). Coordenacao do Porgrama de Submarino com Propulsao Nuclear; Melo, P.F. Frutuoso e [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2015-07-01

    This paper brings a discussion about the challenges involved in the development of a new kind of nuclear facility in Brazil, a naval base for nuclear submarines, with attention to the licensing process and considerations about the risk-informed decision making application to the licensing process. Initially, a model of such a naval base, called in this work, special industrial facility, is proposed, with its systems and respective sets of basic requirements, in order to make it possible the accomplishment of the special industrial facility support function to the nuclear submarine. A discussion about current challenges to overcome in this project is presented: the challenges due to the new characteristics of this type of nuclear facility; existence of several interfaces between the special industrial facilities systems and nuclear submarine systems in design activities; lack of specific regulation in Brazil to allow the licensing process of special industrial facilities by the nuclear safety authority; and comments about the lack of information from reference nuclear facilities, as is the case with nuclear power reactors (for example, the German Grafenrheinfeld nuclear plant is the reference plant for the Brazilian Angra 2 nuclear plant). Finally, in view of these challenges, an analysis method of special industrial facility operational scenarios to assist the licensing process is proposed. Also, considerations about the application of risk-informed decision making to the special industrial facility activity and licensing process in Brazil are presented. (author)

  13. Considerations about the licensing process of special nuclear industrial facilities

    International Nuclear Information System (INIS)

    Talarico, M.A.; Melo, P.F. Frutuoso e

    2015-01-01

    This paper brings a discussion about the challenges involved in the development of a new kind of nuclear facility in Brazil, a naval base for nuclear submarines, with attention to the licensing process and considerations about the risk-informed decision making application to the licensing process. Initially, a model of such a naval base, called in this work, special industrial facility, is proposed, with its systems and respective sets of basic requirements, in order to make it possible the accomplishment of the special industrial facility support function to the nuclear submarine. A discussion about current challenges to overcome in this project is presented: the challenges due to the new characteristics of this type of nuclear facility; existence of several interfaces between the special industrial facilities systems and nuclear submarine systems in design activities; lack of specific regulation in Brazil to allow the licensing process of special industrial facilities by the nuclear safety authority; and comments about the lack of information from reference nuclear facilities, as is the case with nuclear power reactors (for example, the German Grafenrheinfeld nuclear plant is the reference plant for the Brazilian Angra 2 nuclear plant). Finally, in view of these challenges, an analysis method of special industrial facility operational scenarios to assist the licensing process is proposed. Also, considerations about the application of risk-informed decision making to the special industrial facility activity and licensing process in Brazil are presented. (author)

  14. 24 CFR 3286.207 - Process for obtaining installation license.

    Science.gov (United States)

    2010-04-01

    ... installation license must submit verification of the experience required in § 3286.205(a). This verification may be in the form of statements by past or present employers or a self-certification that the applicant meets those experience requirements, but HUD may contact the applicant for additional verification...

  15. Application of activation techniques to biological analysis

    International Nuclear Information System (INIS)

    Bowen, H.J.M.

    1981-01-01

    Applications of activation analysis in the biological sciences are reviewed for the period of 1970 to 1979. The stages and characteristics of activation analysis are described, and its advantages and disadvantages enumerated. Most applications involve activation by thermal neutrons followed by either radiochemical or instrumental determination. Relatively little use has been made of activation by fast neutrons, photons, or charged particles. In vivo analyses are included, but those based on prompt gamma or x-ray emission are not. Major applications include studies of reference materials, and the elemental analysis of plants, marine biota, animal and human tissues, diets, and excreta. Relatively little use of it has been made in biochemistry, microbiology, and entomology, but it has become important in toxicology and environmental science. The elements most often determined are Ag, As, Au, Br, Ca, Cd, Cl, Co, Cr, Cs, Cu, Fe, Hg, I, K, Mn, Mo, Na, Rb, Sb, Sc, Se, and Zn, while few or no determinations of B, Be, Bi, Ga, Gd, Ge, H, In, Ir, Li, Nd, Os, Pd, Pr, Pt, Re, Rh, Ru, Te, Tl, or Y have been made in biological materials

  16. AGING MANAGMENT OF REACTOR COOLANT SYSTEM MECHANICAL COMPONENTS FOR LICENSE RENEWAL

    International Nuclear Information System (INIS)

    SUBUDHI, M.; MORANTE, R.; LEE, A.D.

    2002-01-01

    The reactor coolant system (RCS) mechanical components that require an aging management review for license renewal include the primary loop piping and associated connections to other support systems, reactor vessel, reactor vessel internals, pressurizer. steam generators, reactor coolant pumps, and all other inter-connected piping, pipe fittings, valves, and bolting. All major RCS components are located inside the reactor building. Based on the evaluation findings of recently submitted license renewal applications for pressurized water reactors, this paper presents the plant programs and/or activities proposed by the applicants to manage the effects of aging. These programs and/or activities provide reasonable assurance that the intended function(s) of these mechanical components will be maintained for the period of extended operation. The license renewal application includes identification of RCS subcomponents that are within the scope of license renewal and are vulnerable to age-related degradation when exposed to environmental and operational conditions. determination of the effects of aging on their intended safety functions. and implementation of the aging management programs and/or activities including both current and new programs. Industry-wide operating experience, including generic communication by the NRC, is part of the aging management review for the RCS components. In addition, this paper discusses time-limited aging analyses associated with neutron embrittlement of the reactor vessel beltline region and thermal fatigue

  17. The Atomic Safety and Licensing Board Panel

    International Nuclear Information System (INIS)

    1998-01-01

    Through the Atomic Energy Act, Congress made is possible for the public to get a full and fair hearing on civilian nuclear matters. Individuals who are directly affected by any licensing action involving a facility producing or utilizing nuclear materials may participate in a formal hearing, on the record, before independent judges on the Atomic Safety and Licensing Board Panel (ASLBP or Panel). Frequently, in deciding whether a license, permit, amendment, or extension should be granted to a particular applicant, the Panel members must be more than mere umpires. If appropriate, they are authorized to go beyond the issues the parties place before them in order to identify, explore, and resolve significant questions involving threats to the public health and safety that come to a board's attention during the proceedings. This brochure explains the purpose of the panel. Also addressed are: type of hearing handled; method of public participation; formality of hearings; high-level waste; other panel responsibilities and litigation technology

  18. A Malaysian Vehicle License Plate Localization and Recognition System

    Directory of Open Access Journals (Sweden)

    Ganapathy Velappa

    2008-02-01

    Full Text Available Technological intelligence is a highly sought after commodity even in traffic-based systems. These intelligent systems do not only help in traffic monitoring but also in commuter safety, law enforcement and commercial applications. In this paper, a license plate localization and recognition system for vehicles in Malaysia is proposed. This system is developed based on digital images and can be easily applied to commercial car park systems for the use of documenting access of parking services, secure usage of parking houses and also to prevent car theft issues. The proposed license plate localization algorithm is based on a combination of morphological processes with a modified Hough Transform approach and the recognition of the license plates is achieved by the implementation of the feed-forward backpropagation artificial neural network. Experimental results show an average of 95% successful license plate localization and recognition in a total of 589 images captured from a complex outdoor environment.

  19. 77 FR 43866 - Notice of Intent To Grant a Partially Exclusive License

    Science.gov (United States)

    2012-07-26

    ... license in the United States to practice the inventions described and claimed in U.S. Patent Application..., Virginia. The license may be limited to one or more fields of use. The patent rights in these inventions..., NASA Langley Research Center, MS 30, Hampton, VA 23681; (757) 864-3230 (phone), (757) 864-9190 (fax...

  20. Reactor licensing process: a status report

    International Nuclear Information System (INIS)

    Long, J.A.

    1977-01-01

    The Nuclear Regulatory Commission (NRC), in its review of applications for licenses to construct and operate nuclear power plants, is required to consider those measures necessary to ensure the protection of the health and safety of the public and the environment. The article discusses the NRC staff procedures and policies for conducting the detailed safety, environmental, and antitrust reviews that provide the basis for these assurances. Included is a discussion of the improvements to the licensing process currently being proposed or implemented to enhance its stability and predictability for the benefit of all involved with the regulation of nuclear power. The views and opinions expressed in the article are those of the author alone and do not represent positions of the NRC

  1. Establishment of regulatory framework for the development reactor licensing

    International Nuclear Information System (INIS)

    Jo, Jong C.; Yune, Young G.; Kim, Woong S.; Ahn, Sang K.; Kim, In G.; Kim, Hho J.

    2003-01-01

    With a trend that various types of advanced reactor designs are currently under development worldwide, the Korea Atomic Energy Research Institute has been developing an advanced reactor called ' System-integrated Modular Advanced Reactor (SMART)', which is a small sized integral type pressurized water reactor with a rated thermal power of 330 MW. To demonstrate the safety and the performance of the SMART reactor design, the SMART Research and Development Center has embarked to build a scaled-down pilot plant of SMART, called 'SMART-P' with a rated thermal power of 65 MW. In preparation for the forthcoming applications for both construction permit and operating license of SMART-P in the near future, the Korea Institute of Nuclear Safety is developing a new regulatory framework for licensing review of such a development reactor, which covers establishment of licensing process, identification and resolution of technical and safety issues, development of regulatory evaluation or verification-purpose computer codes and analytical methods, and establishment of design-specific, general design and operating criteria, regulations, and associated regulatory guides. This paper presents the current activities for establishing a regulatory framework for the licensing of a research and development reactor. Discussions are made on the SMART-P development program, the current Korean regulatory framework for reactor licensing, the SMART-P licensing-related issues, and the approach and strategy for developing an effective regulatory framework for the SMART-P licensing

  2. Essays on the economics of licensing nuclear power plants

    International Nuclear Information System (INIS)

    Cohen, L.R.

    1979-01-01

    Regulation and licensing of nuclear power plants by the United States Atomic Energy Commission and the United States Nuclear Regulatory Commission are discussed. Chapter 1 overviews the licensing process and issues raised in licensing cases. Based on a sample of plants licensed between 1967 and 1978, a statistical study of the impact of public participation in licensing is performed. The study concludes that public participation has had a major impact on licensing and power-plant costs. The impact is due to a fundamental weakness of the Commissions: their inability to resolve certain issues related to acceptable social risk. The study has important policy implications for reforming the Federal licensing process. Chapter 2 contains an analysis of the Price-Anderson Act, a Federal program for compensating victims of large nuclear accidents. The Price-Anderson Act is placed within the context of generalized federal disaster relief. A model is developed that allows an evaluation programs on the basis of moral hazard and equity principles. Chapter 3 analyzes the Nuclear Regulatory Commission's treatment of its mandatory antitrust review of applicants for nuclear power plants. The main conclusion of the chapter is that the reviews have not addressed the central economic issues of antitrust that are relevant to nuclear power. Instead, the reviews contribute to further cartelization of the electric utility industry. While politically expedient, the reviews are counter-productive to the development of an optimal industry structure

  3. Licensing activities for advanced reactors in NNC

    International Nuclear Information System (INIS)

    Chevalier, A.B.H.; Mustoe, J.; Walters, J.; Ingham, E.L.

    2001-01-01

    NNC has been involved in safety and licensing activities for advanced reactors for many years. Most recently NNC has been involved with national regulators or their representatives for the HTR (High Temperature Reactor) reactor and the possible siting of ITER (International Thermonuclear Experimental Reactor) within Europe. Commonalties between the two activities can be seen, even though one is a fission process and the other based on a completely new technology. Both have the potential to generate power at a very low overall exposure to the public and station staff, but both also need to demonstrate to the regulator the safety of a design which differs from the standard LWR practice. In both concepts passive design features provide a major part of the safety argument, but the detailed assessment and justification of these features in licensing terms still needs to be made. A number of critical safety issues can be identified, which generally apply to any advanced system. These are: Safety categorization, codes and standards; confinement or containment; ALARA; safety code modelling and data; Occupational Exposure; occupational exposures; decommissioning and waste; no evacuation, or no emergency plans. The UK is notable for a flexible licensing regime, which allows a safety case to be built up from first principles, where this is applicable. In addition, experience of licensing gas cooled, water cooled and liquid metal plant, as well as extensive experience outside the UK provides NNC with a unique insight into the different licensing methodologies which can be applied in the licensing process. This paper discusses some possible approaches which could be applied in order to satisfy regulatory demands when addressing the critical issues listed above. (author)

  4. 77 FR 62521 - Prospective Grant of Exclusive License: The Development of Therapeutic Agents for the Treatment...

    Science.gov (United States)

    2012-10-15

    ... interleukin-10 (IL-10) inhibitor as a dual-biologic therapy to treat metastatic breast cancer, or ii) incorporating a p53 isoform antisense oligonucleotide as a single biologic therapy to treat T- cell lymphoma... Exclusive License: The Development of Therapeutic Agents for the Treatment of Metastatic Breast Cancer and T...

  5. Pc-based car license plate reading

    Science.gov (United States)

    Tanabe, Katsuyoshi; Marubayashi, Eisaku; Kawashima, Harumi; Nakanishi, Tadashi; Shio, Akio

    1994-03-01

    A PC-based car license plate recognition system has been developed. The system recognizes Chinese characters and Japanese phonetic hiragana characters as well as six digits on Japanese license plates. The system consists of a CCD camera, vehicle sensors, a strobe unit, a monitoring center, and an i486-based PC. The PC includes in its extension slots: a vehicle detector board, a strobe emitter board, and an image grabber board. When a passing vehicle is detected by the vehicle sensors, the strobe emits a pulse of light. The light pulse is synchronized with the time the vehicle image is frozen on an image grabber board. The recognition process is composed of three steps: image thresholding, character region extraction, and matching-based character recognition. The recognition software can handle obscured characters. Experimental results for hundreds of outdoor images showed high recognition performance within relatively short performance times. The results confirmed that the system is applicable to a wide variety of applications such as automatic vehicle identification and travel time measurement.

  6. Licensing arrangements and the development of the solar energy industry

    Energy Technology Data Exchange (ETDEWEB)

    Green, M.

    1979-06-01

    The process by which technology and information related to technology are transferred within industry is explored. Property rights in technology are part of the broader field of intellectual property. The general contours of legal protection for knowledge are explored. The four basic forms of intellectual property - patents, trade secrets (or know-how), trademarks, and copyrights - are covered in varying degrees of depth, depending on their relative applicability to the development of the solar industry. Once this background has been established, the legal aspects of licensing are examined. A license is a legal arrangement whereby a party (licensor) who controls the right to use an idea, invention, etc. shares the right to use the particular intellectual property with someone else (licensee). The advantages and disadvantages of licensing are described from the point of view of potential licensees and licensors. Barriers to licensing are discussed.

  7. BioInt: an integrative biological object-oriented application framework and interpreter.

    Science.gov (United States)

    Desai, Sanket; Burra, Prasad

    2015-01-01

    BioInt, a biological programming application framework and interpreter, is an attempt to equip the researchers with seamless integration, efficient extraction and effortless analysis of the data from various biological databases and algorithms. Based on the type of biological data, algorithms and related functionalities, a biology-specific framework was developed which has nine modules. The modules are a compilation of numerous reusable BioADTs. This software ecosystem containing more than 450 biological objects underneath the interpreter makes it flexible, integrative and comprehensive. Similar to Python, BioInt eliminates the compilation and linking steps cutting the time significantly. The researcher can write the scripts using available BioADTs (following C++ syntax) and execute them interactively or use as a command line application. It has features that enable automation, extension of the framework with new/external BioADTs/libraries and deployment of complex work flows.

  8. 50 CFR 660.336 - Pacific whiting vessel licenses.

    Science.gov (United States)

    2010-10-01

    ... groundfish fishing capacity reduction program. NMFS will also make license applications available online at... by that vessel's United States Coast Guard documentation number. (b) [Reserved] [74 FR 10193, Mar. 10, 2009; 74 FR 11881, Mar. 20, 2009] ...

  9. Reactor licensing

    International Nuclear Information System (INIS)

    Harvie, J.D.

    2002-01-01

    This presentation discusses reactor licensing and includes the legislative basis for licensing, other relevant legislation , the purpose of the Nuclear Safety and Control Act, important regulations, regulatory document, policies, and standards. It also discusses the role of the CNSC, its mandate and safety philosophy

  10. Scaling analysis in bepu licensing of LWR

    International Nuclear Information System (INIS)

    D'auria, Francesco; Lanfredini, Marco; Muellner, Nikolaus

    2012-01-01

    'Scaling' plays an important role for safety analyses in the licensing of water cooled nuclear power reactors. Accident analyses, a sub set of safety analyses, is mostly based on nuclear reactor system thermal hydraulics, and therefore based on an adequate experimental data base, and in recent licensing applications, on best estimate computer code calculations. In the field of nuclear reactor technology, only a small set of the needed experiments can be executed at a nuclear power plant; the major part of experiments, either because of economics or because of safety concerns, has to be executed at reduced scale facilities. How to address the scaling issue has been the subject of numerous investigations in the past few decades (a lot of work has been performed in the 80thies and 90thies of the last century), and is still the focus of many scientific studies. The present paper proposes a 'roadmap' to scaling. Key elements are the 'scaling-pyramid', related 'scaling bridges' and a logical path across scaling achievements (which constitute the 'scaling puzzle'). The objective is addressing the scaling issue when demonstrating the applicability of the system codes, the 'key-to-scaling', in the licensing process of a nuclear power plant. The proposed 'road map to scaling' aims at solving the 'scaling puzzle', by introducing a unified approach to the problem.

  11. The Role of License Renewal in PLiM for U.S. Nuclear Power Plants

    International Nuclear Information System (INIS)

    Young, G.G.

    2012-01-01

    At the 2nd International Symposium on Nuclear Power Plant Life Management (PLiM) in 2007, it was reported that the NRC had approved renewal of operating licenses for 48 nuclear units, which would allow operation for up to 60 years (i.e., an additional 20 years from the original 40-year license term). Of the 104 operating nuclear units in the U.S. in 2007, it was anticipated that almost 100% would eventually pursue license renewal. At that time, it was also concluded that the regulatory process was stable and predictable for license renewal, and that successful PLiM activities were helping to ensure the safety, economic, and political factors in the U.S. remained favorable for continued success with license renewal. The status of license renewal in 2012 is even better than it was in 2007. As of April 2012, the NRC has approved renewal of the operating licenses for 71 nuclear units and has applications under review for 15 more units. In addition, nuclear plant owners of at least 14 more units have announced plans to submit license renewal applications over the next few years. This brings the total of renewed licenses and announced plans for license renewal to 96% of the 104 currently operating nuclear units in the U.S. The prediction that almost 100% would eventually pursue license renewal is assured. This positive trend for long term operation of nuclear power plants in the U.S. is attributed to: (1) the success of PLiM activities in achieving an excellent safety record for the nuclear power industry and in ensuring on-going positive economics for nuclear plant operation, and (2) the stable and predictable regulatory process for license renewal. U.S. efforts are now underway to consider long term operation for more than 60 years and the process of preparing a second round of license renewals for up to 80 years of operation is likely to begin within the next few years. (author)

  12. Application of secondary ion mass spectrometry (SIMS) to biological sample analysis

    International Nuclear Information System (INIS)

    Tamura, Hifumi

    1990-01-01

    Some major issues and problems related with the analysis of biological samples are discussed, focusing on demonstrated and possible solutions and the application of secondary ion mass spectrometry (SIMS) to investigation of the composition of biological samples. The effective use of secondary electrons in combination with negative ions is most practical for the analysis of biological samples. Regardless of whether positive or negative ions are used, the electric potential at the surface of a sample stays around a constant value because of the absense of the accumulation of electric charges at the surface, leading to almost complete avoidance of the charging of the biological sample. A soft tissue sample can suffer damage to the tissue or migration of atoms in removing water from the sample. Some processes including fixation and freeze drying are available to prevent this. The application of SIMS to biological analysis is still in the basic research stage and further studies will be required to develop practical methods. Possible areas of its application include medicine, pathology, toxicology, pharmacology, plant physiology and other areas related with marine life and marine contamination. (N.K.)

  13. On the reform of nuclear licensing procedures for plants and operation

    International Nuclear Information System (INIS)

    Lecheler, H.

    1977-01-01

    The nuclear licensing procedures require basic reforming. In doing so, there must be a differentiation between (concrete) licensing of plants and (abstract) decisions on site provision. The provision of sites is exercised directly by the diets of the Laender. For this purpose they enact planning laws on sites for nuclear power plants of different sizes. As far as the Federal law is touched upon (especially the Federal act on construction), the Federal legislator has to concede competences to the Laender. No. 6 of section 7 II of the Atomic Energy Act would have to be deleted. The plant licensing procedure is to be limited to a mere safety check-up of a concrete plant. Licensing prerequisites of the Atomic Energy Act are to be made more precise by the Federal legislator, namely by deciding unequivocally the purpose of the law, whether priority is given to promotion or to protection, and by making the enacting of tangible regulations a duty. When these licensing prerequisites exist, the law has to concede the applicant a plain title to licensing. (orig.) [de

  14. Biological applications of the Moessbauer effect; Applications de l'effet Mossbauer a la biologie

    Energy Technology Data Exchange (ETDEWEB)

    Boulay, P [CEA Bruyeres-le-Chatel, 91 (France)

    1968-12-01

    The applications of Moessbauer spectrometry in the fields of physics and chemistry have been increasing steadily since its discovery in 1958. Attempts have been made to find applications in biology. Two possibilities of investigation exist in this field: the study of mechanical or vibrational movements in certain animal organs, and the determination of the organic molecular structure in a biological context. An example is given of each of these possibilities. (author) [French] Les applications de la spectrometrie Mossbauer dans le domaine de la physique et de la chimie n'ont cesse de progresser depuis sa decouverte en 1958. Des essais d'application a la biologie ont ete entrepris. Dans ce domaine il existe deux possibilites d'investigation: l'etude des mouvements mecaniques ou vibratoires de certaines organes d'animaux, et la determination de la structure moleculaire organique a destinee biologique. Un exemple est donne de chacune de ces possibilites. (auteur)

  15. 75 FR 54656 - Government-Owned Inventions, Available for Licensing

    Science.gov (United States)

    2010-09-08

    ... availability of inventions for licensing. SUMMARY: Patent applications on the inventions listed below assigned..., Pasadena, CA 91109; telephone (818) 354-7770. NASA Case No.: NPO-46771-1: Diamond Heat-Spreader for...

  16. 78 FR 31570 - Prospective Grant of a Start-Up Exclusive Patent License Agreement: Treatment of Graves' Disease...

    Science.gov (United States)

    2013-05-24

    ...-Up Exclusive Patent License Agreement: Treatment of Graves' Disease, Hyperthyroidism and Thyroid... Patent License Agreement may be worldwide and the field of use may be limited to: Treatment of Graves' Disease, hyperthyroidism and thyroid cancer. DATES: Only written comments or applications for a license...

  17. Evolutionary cell biology: functional insight from "endless forms most beautiful".

    Science.gov (United States)

    Richardson, Elisabeth; Zerr, Kelly; Tsaousis, Anastasios; Dorrell, Richard G; Dacks, Joel B

    2015-12-15

    In animal and fungal model organisms, the complexities of cell biology have been analyzed in exquisite detail and much is known about how these organisms function at the cellular level. However, the model organisms cell biologists generally use include only a tiny fraction of the true diversity of eukaryotic cellular forms. The divergent cellular processes observed in these more distant lineages are still largely unknown in the general scientific community. Despite the relative obscurity of these organisms, comparative studies of them across eukaryotic diversity have had profound implications for our understanding of fundamental cell biology in all species and have revealed the evolution and origins of previously observed cellular processes. In this Perspective, we will discuss the complexity of cell biology found across the eukaryotic tree, and three specific examples of where studies of divergent cell biology have altered our understanding of key functional aspects of mitochondria, plastids, and membrane trafficking. © 2015 Richardson et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  18. Nuclear reactor operator licensing

    International Nuclear Information System (INIS)

    Bursey, R.J.

    1978-01-01

    The Atomic Energy Act of 1954, which was amended in 1974 by the Energy Reorganization Act, established the requirement that individuals who had the responsibility of operating the reactors in nuclear power plants must be licensed. Section 107 of the act states ''the Commission shall (1) prescribe uniform conditions for licensing individuals; (2) determine the qualifications of such individuals; and (3) issue licenses to such individuals in such form as the Commission may prescribe.'' The article discusses the types of licenses, the selection and training of individuals, and the administration of the Nuclear Regulatory Commission licensing examinations

  19. No longer "if," but "when": the coming abbreviated approval pathway for follow-on biologics.

    Science.gov (United States)

    Kelly, Jeremiah J; David, Michael

    2009-01-01

    Abbreviated approval of follow-on biologics involves answering complex scientific, legal, and policy questions. The Food and Drug Administration (FDA or the Agency) asserts that it lacks the statutory authority to approve follow-on versions of biologics licensed under Section 351 of the Public Health Service Act (PHSA). Despite persuasive arguments to the contrary the one hundred and tenth Congress entertained four legislative proposals to give FDA this authority, each markedly different. It is no longer a question of "if," but "when" FDA will receive authority to review and license abbreviated applications for follow-on biologics. Any legislation in the one hundred and eleventh Congress must determine: (1) if FDA should be granted authority to develop an abbreviated pathway through rulemaking or guidance; (2) if human clinical trials should be mandatory or discretionary; (3) the feasibility of interchangeability determinations in light of patient safety concerns; (4) the duration of marketing exclusivity for associated products; (5) which products are eligible for follow-on approval; and (6) the degree to which uniformity is achievable between the FD&C Act and the PHSA. This paper recommends the one hundred and eleventh Congress strike a balance between patient safety, incentives for product innovation, price competition, and the need for a flexible, transparent process that capitalizes on FDA's growing expertise with follow-on biologics approvals under Section 505(b)(2) of the FD&C Act.

  20. 77 FR 20823 - Prospective Grant of Exclusive License: Family Healthware

    Science.gov (United States)

    2012-04-06

    ... application referred to below to Sanitas Inc., having a place of business in La Jolla, California. The patent... and prevention strategies. ADDRESSES: Requests for a copy of this patent application, inquiries....D., Ph.D., Technology Licensing and Marketing Specialist, Technology Transfer Office, Centers for...

  1. Licensing in an international triopoly

    Science.gov (United States)

    Ferreira, Fernanda A.; Ferreira, Flávio

    2011-12-01

    We study the effects of entry of two foreign firms on domestic welfare in the presence of licensing, when the incumbent is technologically superior to the entrants. We consider two different situations: (i) the cost-reducing innovation is licensed to both entrants; (ii) the cost-reducing innovation is licensed to just one of the entrants. We analyse three kind of license: (lump-sum) fixed-fee; (per-unit) royalty; and two-part tariff, that is a combination of a fixed-fee and a royalty. We prove that a two part tariff is never an optimal licensing scheme for the incumbent. Moreover, (i) when the technology is licensed to the two entrants, the optimal contract consists of a licensing with only output royalty; and (ii) when the technology is licensed to just one of the entrants, the optimal contract consists of a licensing with only a fixed-fee.

  2. Heat transfer and fluid flow in biological processes advances and applications

    CERN Document Server

    Becker, Sid

    2015-01-01

    Heat Transfer and Fluid Flow in Biological Processes covers emerging areas in fluid flow and heat transfer relevant to biosystems and medical technology. This book uses an interdisciplinary approach to provide a comprehensive prospective on biofluid mechanics and heat transfer advances and includes reviews of the most recent methods in modeling of flows in biological media, such as CFD. Written by internationally recognized researchers in the field, each chapter provides a strong introductory section that is useful to both readers currently in the field and readers interested in learning more about these areas. Heat Transfer and Fluid Flow in Biological Processes is an indispensable reference for professors, graduate students, professionals, and clinical researchers in the fields of biology, biomedical engineering, chemistry and medicine working on applications of fluid flow, heat transfer, and transport phenomena in biomedical technology. Provides a wide range of biological and clinical applications of fluid...

  3. 47 CFR 22.960 - Cellular unserved area radiotelephone licenses subject to competitive bidding.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Cellular unserved area radiotelephone licenses... (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Cellular Radiotelephone Service § 22.960 Cellular... applications for cellular unserved area Phase I and Phase II licenses filed after July 26, 1993 are subject to...

  4. Cellular potts models multiscale extensions and biological applications

    CERN Document Server

    Scianna, Marco

    2013-01-01

    A flexible, cell-level, and lattice-based technique, the cellular Potts model accurately describes the phenomenological mechanisms involved in many biological processes. Cellular Potts Models: Multiscale Extensions and Biological Applications gives an interdisciplinary, accessible treatment of these models, from the original methodologies to the latest developments. The book first explains the biophysical bases, main merits, and limitations of the cellular Potts model. It then proposes several innovative extensions, focusing on ways to integrate and interface the basic cellular Potts model at the mesoscopic scale with approaches that accurately model microscopic dynamics. These extensions are designed to create a nested and hybrid environment, where the evolution of a biological system is realistically driven by the constant interplay and flux of information between the different levels of description. Through several biological examples, the authors demonstrate a qualitative and quantitative agreement with t...

  5. 75 FR 3244 - Prospective Grant of Exclusive License: Monoclonal Antibodies Against Smallpox/Orthopoxviruses

    Science.gov (United States)

    2010-01-20

    ... Exclusive License: Monoclonal Antibodies Against Smallpox/Orthopoxviruses AGENCY: National Institutes of.... SUPPLEMENTARY INFORMATION: Concerns that variola (smallpox) virus might be used as a biological weapon have led... safe and effective for prevention of smallpox, it is well documented that various adverse reactions in...

  6. Review of the Brazilian experience in the licensing of nuclear power plants

    International Nuclear Information System (INIS)

    Lederman, L.; Laborne, J.J.

    1983-01-01

    Survey of the licensing of the Brazilian Nuclear Power Plants (NPPs) is presented. The organization and technical expertise of the Comissao Nacional de Energia Nuclear, the Brazilian Regulatory Body, is reviewed with regard to in-house experience, foreign consultants, agreements with regulatory bodies of other countries and research contracts with Brazilian univerisities. The application of the two-stage licensing process and the stage of development of Brazilian nuclear standards is described. Finally, the paper speculates about the future role of probabilistic risk assessment in the Brazilian licensing process

  7. Outline for embedded topical license renewal industry perspective

    International Nuclear Information System (INIS)

    Gilchrist, Jacqueline

    1991-01-01

    This presentation describes the history of the project, selection of the Lead plant; project management, and project implementation, License renewal application contains: implementation plan; technical specifications and program changes; updated safety analysis report supplement; plant specific exemptions; environmental report update

  8. Performance assessment and licensing issues for United States commercial near-surface low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Birk, S. M.

    1997-01-01

    This paper covers the performance assessment and licensing issues, the performance the objectives, the performance assessment phases, the scenario selection, the mathematical modeling and computer programs, the final results of performance assessments submitted for license applications, the institutional control period, and the licensing issues. 38 refs

  9. Beyond the Biology: A Systematic Investigation of Noncontent Instructor Talk in an Introductory Biology Course.

    Science.gov (United States)

    Seidel, Shannon B; Reggi, Amanda L; Schinske, Jeffrey N; Burrus, Laura W; Tanner, Kimberly D

    2015-01-01

    Instructors create classroom environments that have the potential to impact learning by affecting student motivation, resistance, and self-efficacy. However, despite the critical importance of the learning environment in increasing conceptual understanding, little research has investigated what instructors say and do to create learning environments in college biology classrooms. We systematically investigated the language used by instructors that does not directly relate to course content and defined the construct of Instructor Talk. Transcripts were generated from a semester-long, cotaught introductory biology course (n = 270 students). Transcripts were analyzed using a grounded theory approach to identify emergent categories of Instructor Talk. The five emergent categories from analysis of more than 600 quotes were, in order of prevalence, 1) Building the Instructor/Student Relationship, 2) Establishing Classroom Culture, 3) Explaining Pedagogical Choices, 4) Sharing Personal Experiences, and 5) Unmasking Science. Instances of Instructor Talk were present in every class session analyzed and ranged from six to 68 quotes per session. The Instructor Talk framework is a novel research variable that could yield insights into instructor effectiveness, origins of student resistance, and methods for overcoming stereotype threat. Additionally, it holds promise in professional development settings to assist instructors in reflecting on the learning environments they create. © 2015 S. B. Seidel et al. CBE—Life Sciences Education © 2015 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  10. 76 FR 4920 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2011-01-27

    ... sequences of microRNAs. The application also claims live attenuated chimeric flaviviruses, where the first... appear to be distinct from each other. Available for licensing is a Plk1 ELISA assay using peptide...

  11. Demarcation of the licensing and supervisory procedures for nuclear engineering installations

    International Nuclear Information System (INIS)

    Schattke, H.

    1986-01-01

    The remarks can be summed up under 12 points: 1) The protective purpose outlined in Paragraph 1 No. 2 of the Atomic Energy Law is the top priority for both licensing and regulatory authorities. 2) Both authorities must aim at the best possible prevention of hazards and precautions against risks. 3) The licensing procedures cover applications for licenses, the regulatory procedures check and supervise actual activities. 4) The licensing procedures take precedence in chronology and in substance over the regulatory procedure. 5) The licensing procedure is a preliminary check on the intention to carry out nuclear activities before the event; whereas the regulatory procedure controls the licensee after the event to ensure that the latter's activities really do conform to the framework laid down in the license. 6) The licensing procedure must be verified by state supervision with regard to its prognostic activity. 7) The examination criteria are largely identical for both the authorites. 8) The examination tools for the licensing and regulatory authorities also coincide to a large extent. Legal differences in the possible means of enforcement have no effect in practice. 9) Decisions made by either authority can be either in the licensee's favour or to its disadvantage. Nevertheless, the contents of decisions differ widely between the two authorities. 10) The regulatory authorities execute and prepare the decisions of the licensing authorites. 11) Licensing decisions can be designated static/prognostic, whereas regulatory measures accompany the actual performance of the plant and the operating personnel in a dynamic/controlling manner. 12) Regulatory instructions are usually of a temporary nature, whereas licensing actions are permanent as a rule. (orig.) [de

  12. NRC's license renewal regulations

    International Nuclear Information System (INIS)

    Akstulewicz, Francis

    1991-01-01

    In order to provide for the continuity of the current generation of nuclear power plant operating licenses and at the same time ensure the health and safety of the public, and the quality of the environment, the US Nuclear Regulatory Commission (NRC) established a goal of developing and issuing regulations and regulatory guidance for license renewal in the early 1990s. This paper will discuss some of those activities underway to achieve this goal. More specifically, this paper will discuss the Commission's regulatory philosophy for license renewal and the two major license renewal rule makings currently underway. The first is the development of a new Part 54 to address procedural and technical requirements for license renewal; the second is a revision to existing Part 51 to exclude environmental issues and impacts from consideration during the license renewal process. (author)

  13. The changing shape of U.S. licensing philosophy

    International Nuclear Information System (INIS)

    Remick, F.J.

    1992-01-01

    The shape of U.S. nuclear licensing and regulatory philosophy and process has already changed. The new process requires NRC review and approval of the vendor designs before a prospective utility license applicant purchases the design and begins construction. The new philosophy has resulted from the lessons learned from extensive operating experience accumulated in the United States. New criteria established for judging reactor designs include the capability of future designs to be more tolerant of accidents beyond the traditional design basis events. Qualitative and quantitative goals have been chosen as a guide for allocating resources for regulation of the currently operating plants. The changing shape of nuclear licensing and regulatory philosophy is also a result of economic circumstances in the United States. All will have a better opportunity to take part in the process which is most likely to encourage further development of safe nuclear energy in the United States. (author)

  14. Commitment tracking in the licensing renewal process: A perspective

    International Nuclear Information System (INIS)

    Gurican, Gregory M.; Breslauer, Stephen K.

    1991-01-01

    The NRC's proposed 10 CFR 54 defines 'Current licensing basis' as inclusive of all licensee commitments. During the last five years, the regulatory commitment tracking group (RCTG) has been developing guidance for member utilities to track such commitments. The RCTG guidance for commitment tracking assists utilities in developing a system to store and maintain commitments related to the CLB. But a majority believe it unlikely that any one commitment tracking system will capture all commitments contained in the proposed definition of a 'Current Licencing Basis'. For future renewal applications the NRC proposes that utilities must identify and compile all licensing basis commitments. In addition, utilities 'shall maintain...(them) in an auditable and retrievable form'. Some utilities are already compiling and tracking licensing basis commitments; others are not. (author)

  15. Licensed Healthcare Facilities

    Data.gov (United States)

    California Natural Resource Agency — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  16. Effects of Californian PRC 25500 on nuclear power plant licensing

    International Nuclear Information System (INIS)

    Hahn, F.J.

    1976-01-01

    The California Public Resources Code 25500 established the Energy Resources Conservation and Development Commission on January 7, 1976. This Act mandated that the Commission process applications for new power plants within very specific timeframes. The paper presents the intent and timing of the two-phase licensing procedure and illustrates the effect of this procedure on power plants already into the NRC licensing process and on power plants which are in the beginning of the site selection process

  17. [Mass spectrometry technology and its application in analysis of biological samples].

    Science.gov (United States)

    Zhao, Long-Shan; Li, Qing; Guo, Chao-Wei; Chen, Xiao-Hui; Bi, Kai-Shun

    2012-02-01

    With the excellent merits of wide analytical range, high sensitivity, small sample size, fast analysis speed, good repeatability, simple operation, low mobile phase consumption, as well as its capability of simultaneous isolation and identification, etc, mass spectrometry techniques have become widely used in the area of environmental science, energy chemical industry, biological medicine, and so on. This article reviews the application of mass spectrometry technology in biological sample analysis in the latest three years with the focus on the new applications in pharmacokinetics and bioequivalence, toxicokinetics, pharmacokinetic-pharmacodynamic, population pharmacokinetics, identification and fragmentation pathways of drugs and their metabolites and metabonomics to provide references for further study of biological sample analysis.

  18. 2015 Business Licenses

    Data.gov (United States)

    City of Jackson, Mississippi — This data displays all business license information for the year of 2015. This information details license classifications and status. This information will updated...

  19. Teenagers' licensing decisions and their views of licensing policies: a national survey.

    Science.gov (United States)

    Williams, Allan F

    2011-08-01

    One objective was to determine teenage licensing rates on a national basis, interest in early licensure, and reasons for delay. A second objective was to learn teenagers' opinions about licensing policies, important in states considering ways to upgrade their current licensing systems. One thousand three hundred eighty-three 15- to 18-year-olds completed an online survey in November 2010. They were drawn from a nationally representative panel of US households recruited using probability-based sampling. The panel included cell phone-only households, and Internet access was provided to those without it. Weighting procedures were applied so that the study population represented the national US population of 15- to 18-year-olds. Most teens said that they were interested in getting a license as soon as legally possible, but many had not started the process. At 16, teens were about equally divided among those who had not started, those in the learner stage, and those with a restricted or full license. At 18, 62 percent had full licenses; 22 percent had not started. For those old enough to start, lack of a car, costs, parent availability, ability to get around without a car, and being busy with other activities were leading reasons for delay. The majority of teens were not in favor of higher licensing ages. Forty-six percent thought the minimum learner age should be 16; 30 percent thought the full license age should be 18 or older. The majority approved of night (78%) and passenger (57%) restrictions, and 85 and 93 percent endorsed cell phone and texting bans, respectively. When these policies were packaged together in a single law that included an age 16 start, night, passenger, cell phone and texting bans, and a full license at age 18, 74 percent of teens were in favor. Teenagers are not as supportive of strong licensing policies as parents of teens, but there is evidence that they will support comprehensive policies likely to lead to further reductions in teen crash

  20. Licensing of radioactive materials and facilities in the Philippines

    International Nuclear Information System (INIS)

    Mateo, A.J.

    1976-12-01

    The importation, acquisition, possession, use, sale and/ or transfer of radioactive materials need to be regulated and controlled in order to safeguard the importer, possessor, user or seller and the general public as well. The Philippine Atomic Energy Commission pursuant to Republic Act No. 2067, as amended and Republic Act No. 5207, has been charged by the government to control, regulate and license all the radioactive materials and facilities in the Philippines. Licensing and control is accomplished through a system of rules and regulations applicable to all importers, possessors, users or sellers of radioactive materials

  1. NRC Licensing Status Summary Report for NGNP

    Energy Technology Data Exchange (ETDEWEB)

    Moe, Wayne Leland [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinsey, James Carl [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-11-01

    The Next Generation Nuclear Plant (NGNP) Project, initiated at Idaho National Laboratory (INL) by the U.S. Department of Energy (DOE) pursuant to provisions of the Energy Policy Act of 2005, is based on research and development activities supported by the Department of Energy Generation IV Nuclear Energy Systems Initiative. The principal objective of the NGNP Project is to support commercialization of high temperature gas-cooled reactor (HTGR) technology. The HTGR is a helium-cooled and graphite moderated reactor that can operate at temperatures much higher than those of conventional light water reactor (LWR) technologies. The NGNP will be licensed for construction and operation by the Nuclear Regulatory Commission (NRC). However, not all elements of current regulations (and their related implementation guidance) can be applied to HTGR technology at this time. Certain policies established during past LWR licensing actions must be realigned to properly accommodate advanced HTGR technology. A strategy for licensing HTGR technology was developed and executed through the cooperative effort of DOE and the NRC through the NGNP Project. The purpose of this report is to provide a snapshot of the current status of the still evolving pre-license application regulatory framework relative to commercial HTGR technology deployment in the U.S. The following discussion focuses on (1) describing what has been accomplished by the NGNP Project up to the time of this report, and (2) providing observations and recommendations concerning actions that remain to be accomplished to enable the safe and timely licensing of a commercial HTGR facility in the U.S.

  2. Mobile-based biology edutainment application for secondary schools

    Science.gov (United States)

    AL-Modwahi, Ashraf Abbas M.; Kaisara, Onalenna; Parkizkar, Behrang; Habibi Lashkari, Arash

    2013-03-01

    The high increase of mobile technology is leading to mobilized learning environment, thus making traditional learning to diminish slowly and become inactive and unproductive. Learners worldwide are being attracted to mobile environment more so that it promotes anytime, anywhere learning. Biology as a secondary school subject will be applicable for mobile learning for such a time and generation as this. This paper is therefore an attempt to mobile based biology edutainment system for the students who normally range from the ages of thirteen to sixteen.

  3. Radiopharmaceutical licensing

    International Nuclear Information System (INIS)

    Mather, S.J.

    1992-01-01

    Recent health service legislation, and especially the loss of crown immunity has once again focussed attention on the arrangements for licensing of radiopharmaceuticals. The aim of the article is to describe in general terms the UK licensing system and in particular to provide guidance to those responsible for the supply of radiopharmaceuticals in hospitals. (author)

  4. Review on thin-film transistor technology, its applications, and possible new applications to biological cells

    Science.gov (United States)

    Tixier-Mita, Agnès; Ihida, Satoshi; Ségard, Bertrand-David; Cathcart, Grant A.; Takahashi, Takuya; Fujita, Hiroyuki; Toshiyoshi, Hiroshi

    2016-04-01

    This paper presents a review on state-of-the-art of thin-film transistor (TFT) technology and its wide range of applications, not only in liquid crystal displays (TFT-LCDs), but also in sensing devices. The history of the evolution of the technology is first given. Then the standard applications of TFT-LCDs, and X-ray detectors, followed by state-of-the-art applications in the field of chemical and biochemical sensing are presented. TFT technology allows the fabrication of dense arrays of independent and transparent microelectrodes on large glass substrates. The potential of these devices as electrical substrates for biological cell applications is then described. The possibility of using TFT array substrates as new tools for electrical experiments on biological cells has been investigated for the first time by our group. Dielectrophoresis experiments and impedance measurements on yeast cells are presented here. Their promising results open the door towards new applications of TFT technology.

  5. Guide for the preparation of applications for special nuclear material licenses of less than critical mass quantities - July 1976

    International Nuclear Information System (INIS)

    Anon.

    1977-01-01

    This guide describes the type of information needed to evaluate an application for a specific license for receipt, possession, use, and transfer of special nuclear material. It is intended for applicants requesting authorization to possess and use up to 2000 grams of plutonium, total, in the form of sealed plutonium-beryllium neutron sources, and any special nuclear material in quantities and forms not sufficient to form a critical mass. The latter quantities are considered to be 350 grams of contained uranium-235, 200 grams of uranium-233, 200 grams of plutonium (in any form other than plutonium-beryllium neutron sources) or any combination of them

  6. State Licenses & Permits

    Data.gov (United States)

    Small Business Administration — Starting a business? Confused about whether you need a business license or permit? Virtually every business needs some form of license or permit to operate legally....

  7. The SLOWPOKE licensing model

    Energy Technology Data Exchange (ETDEWEB)

    Snell, V. G.; Takats, F.; Szivos, K.

    1989-08-15

    The SLOWPOKE Energy System (SES-10) is a 10 MW heating reactor that has been developed in Canada. It will be capable of running without a licensed operator in continuous attendance, and will be sited in urban areas. It has forgiving safety characteristics, including transient time-scales of the order of hours. A process called `up-front` licensing has been evolved in Canada to identify, and resolve, regulatory concerns early in the process. Because of the potential market in Hungary for nuclear district heating, a licensing plan has been developed that incorporates Canadian licensing experience, identifies specific Hungarian requirements, and reduces the risk of licensing delays by seeking agreement of all parties at an early stage in the program.

  8. Nuclear safety requirements for operation licensing of Egyptian research reactors

    International Nuclear Information System (INIS)

    Ahmed, E.E.M.; Rahman, F.A.

    2000-01-01

    From the view of responsibility for health and nuclear safety, this work creates a framework for the application of nuclear regulatory rules to ensure safe operation for the sake of obtaining or maintaining operation licensing for nuclear research reactors. It has been performed according to the recommendations of the IAEA for research reactor safety regulations which clearly states that the scope of the application should include all research reactors being designed, constructed, commissioned, operated, modified or decommissioned. From that concept, the present work establishes a model structure and a computer logic program for a regulatory licensing system (RLS code). It applies both the regulatory inspection and enforcement regulatory rules on the different licensing process stages. The present established RLS code is then applied to the Egyptian Research Reactors, namely; the first ET-RR-1, which was constructed and still operating since 1961, and the second MPR research reactor (ET-RR-2) which is now in the preliminary operation stage. The results showed that for the ET-RR-1 reactor, all operational activities, including maintenance, in-service inspection, renewal, modification and experiments should meet the appropriate regulatory compliance action program. Also, the results showed that for the new MPR research reactor (ET-RR-2), all commissioning and operational stages should also meet the regulatory inspection and enforcement action program of the operational licensing safety requirements. (author)

  9. License to build

    International Nuclear Information System (INIS)

    Huntelaar, Mark; Vos, Renate de; Roobol, Lars

    2007-01-01

    Full text: A new license under the nuclear power act is applied for at the Dutch Government for the building of a High Active Repackaging Unit (HAVA-VU in Dutch) at NRG in Petten, The Netherlands. This new building is necessary to comply with our nuclear license to dispose of high active nuclear waste at Petten to the intermediate storage facility (COVRA). In the first part of this paper attention is given to the formal procedure followed by the Government, what type of documents are to be submitted, what time frames are followed, how citizen participation is organized, and as final result a new license. In the second part more detailed information is given about the present license renewal needed for the High Active Repackaging Unit

  10. License renewal demonstration program: NRC observations and lessons learned

    International Nuclear Information System (INIS)

    Prato, R.J.; Kuo, P.T.; Newberry, S.F.

    1996-12-01

    This report summarizes the Nuclear Regulatory Commission staff's observations and lessons learned from the five License Renewal Demonstration Program (LRDP) site visits performed by the staff from March 25, 1996, through August 16, 1996. The LRDP was a Nuclear Energy Institute (NEI) program intended to assess the effectiveness of the guidance provided by NEI 95-10, Revision 0, open-quotes Industry Guideline for Implementing the Requirements of 10 CFR Part 54 - The License Renewal Rule,close quotes to implement the requirements of Title 10 of the Code of Federal Regulations, Part 54 (10 CFR Part 54), open-quotes Requirements for Renewal of Operating Licenses for Nuclear Power Plants.close quotes In general, NEI 95-10 appeared to contain the basic guidance needed for scoping, screening, identifying aging effects, developing aging management programs, and performing time-limited aging analyses. However, inconsistent implementation of this guidance in some areas was an indication that clarification of existing guidance and/or the inclusion-of some new guidance may be needed for applicants to develop a license renewal program that is consistent with the intent of the rule

  11. Some Issues of Biological Shape Modelling with Applications

    DEFF Research Database (Denmark)

    Larsen, Rasmus; Hilger, Klaus Baggesen; Skoglund, Karl

    2003-01-01

    This paper illustrates current research at Informatics and Mathematical Modelling at the Technical University of Denmark within biological shape modelling. We illustrate a series of generalizations to, modifications to, and applications of the elements of constructing models of shape or appearance...

  12. Transcription control engineering and applications in synthetic biology

    Directory of Open Access Journals (Sweden)

    Michael D. Engstrom

    2017-09-01

    Full Text Available In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein, a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators (cis-factors were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators (trans-factors, giving examples of how cis- and trans-acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli, we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

  13. Transcription control engineering and applications in synthetic biology.

    Science.gov (United States)

    Engstrom, Michael D; Pfleger, Brian F

    2017-09-01

    In synthetic biology, researchers assemble biological components in new ways to produce systems with practical applications. One of these practical applications is control of the flow of genetic information (from nucleic acid to protein), a.k.a. gene regulation. Regulation is critical for optimizing protein (and therefore activity) levels and the subsequent levels of metabolites and other cellular properties. The central dogma of molecular biology posits that information flow commences with transcription, and accordingly, regulatory tools targeting transcription have received the most attention in synthetic biology. In this mini-review, we highlight many past successes and summarize the lessons learned in developing tools for controlling transcription. In particular, we focus on engineering studies where promoters and transcription terminators ( cis -factors) were directly engineered and/or isolated from DNA libraries. We also review several well-characterized transcription regulators ( trans- factors), giving examples of how cis- and trans -acting factors have been combined to create digital and analogue switches for regulating transcription in response to various signals. Last, we provide examples of how engineered transcription control systems have been used in metabolic engineering and more complicated genetic circuits. While most of our mini-review focuses on the well-characterized bacterium Escherichia coli , we also provide several examples of the use of transcription control engineering in non-model organisms. Similar approaches have been applied outside the bacterial kingdom indicating that the lessons learned from bacterial studies may be generalized for other organisms.

  14. Scaling analysis in bepu licensing of LWR

    Energy Technology Data Exchange (ETDEWEB)

    D' auria, Francesco; Lanfredini, Marco; Muellner, Nikolaus [University of Pisa, Pisa (Italy)

    2012-08-15

    'Scaling' plays an important role for safety analyses in the licensing of water cooled nuclear power reactors. Accident analyses, a sub set of safety analyses, is mostly based on nuclear reactor system thermal hydraulics, and therefore based on an adequate experimental data base, and in recent licensing applications, on best estimate computer code calculations. In the field of nuclear reactor technology, only a small set of the needed experiments can be executed at a nuclear power plant; the major part of experiments, either because of economics or because of safety concerns, has to be executed at reduced scale facilities. How to address the scaling issue has been the subject of numerous investigations in the past few decades (a lot of work has been performed in the 80thies and 90thies of the last century), and is still the focus of many scientific studies. The present paper proposes a 'roadmap' to scaling. Key elements are the 'scaling-pyramid', related 'scaling bridges' and a logical path across scaling achievements (which constitute the 'scaling puzzle'). The objective is addressing the scaling issue when demonstrating the applicability of the system codes, the 'key-to-scaling', in the licensing process of a nuclear power plant. The proposed 'road map to scaling' aims at solving the 'scaling puzzle', by introducing a unified approach to the problem.

  15. History of the medical licensing examination (uieop in Korea’s Goryeo Dynasty (918-1392

    Directory of Open Access Journals (Sweden)

    Kyung-Lock Lee

    2015-05-01

    Full Text Available This article aims to describe the training and medical licensing system (uieop for becoming a physician officer (uigwan during Korea’s Goryeo Dynasty (918-1392. In the Goryeo Dynasty, although no license was necessary to provide medical services to the common people, there was a licensing examination to become a physician officer. No other national licensing system for healthcare professionals existed in Korea at that time. The medical licensing examination was administered beginning in 958. Physician officers who passed the medical licensing examination worked in two main healthcare institutions: the Government Hospital (Taeuigam and Pharmacy for the King (Sangyakguk. The promotion and expansion of medical education differed depending on the historical period. Until the reign of King Munjong (1046-1083, medical education as a path to licensure was encouraged in order to increase the number of physician officers qualifying for licensure by examination; thus, the number of applicants sitting for the examination increased. However, in the late Goryeo Dynasty, after the officer class of the local authorities (hyangri showed a tendency to monopolize the examination, the Goryeo government limited the examination applications by this group. The medical licensing examination was divided into two parts: medicine and ‘feeling the pulse and acupuncture’ (jugeumeop. The Goryeo Dynasty followed the Chinese Dang Dynasty’s medical system while also taking a strong interest in the Chinese Song Dynasty’s ideas about medicine.

  16. AREVA solutions to licensing challenges in PWR and BWR reload and safety analysis

    Energy Technology Data Exchange (ETDEWEB)

    Curca-Tivig, Florin [AREVA GmbH, Erlangen (Germany)

    2016-05-15

    Regulatory requirements for reload and safety analyses are evolving: new safety criteria, request for enlarged qualification databases, statistical applications, uncertainty propagation.. In order to address these challenges and access more predictable licensing processes, AVERA is implementing consistent code and methodology suites for PWR and BWR core design and safety analysis, based on first principles modeling and extremely broad verification and validation data base. Thanks to the high computational power increase in the last decades methods' development and application now include new capabilities. An overview of the main AREVA codes and methods developments is given covering PWR and BWR applications in different licensing environments.

  17. Evaluation of Terminated Nuclear Material Licenses

    International Nuclear Information System (INIS)

    Spencer, K.M.; Zeighami, E.A.

    1999-01-01

    This report presents the results of a six-year project that reviewed material licenses that had been terminated during the period from inception of licensing until approximately late-1994. The material licenses covered in the review project were Part 30, byproduct material licenses; Part 40, source material licenses; and Part 70, special nuclear material licenses. This report describes the methodology developed for the project, summarizes the findings of the license file inventory process, and describes the findings of the reviews or evaluations of the license files. The evaluation identified nuclear material use sites that need review of the licensing material or more direct follow-up of some type. The review process also identified licenses authorized to possess sealed sources for which there was incomplete or missing documentation of the fate of the sources

  18. 47 CFR 25.142 - Licensing provisions for the non-voice, non-geostationary mobile-satellite service.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Licensing provisions for the non-voice, non-geostationary mobile-satellite service. 25.142 Section 25.142 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS Applications and Licenses Space...

  19. Assessment report: Application from OKG AB for a license according to the Act on Nuclear Activities concerning a shallow land burial/landfill for low-level nuclear waste in Simpevarp in the Oskarshamn municipality

    International Nuclear Information System (INIS)

    Lindbom, G.; Wiebert, A.; Norden, M.; Larsson, Carl-Magnus; Loefgren, T.; Lumpus, J.

    2000-10-01

    OKG AB has to SSI submitted an application for a license according to the Act on Nuclear Activities (1984:3) concerning a shallow land burial/landfill for low-level nuclear waste in Simpevarp in the Oskarshamn municipality. The application for a license covers permission to build, possess and operate a shallow land burial/landfill for low-level nuclear waste. Attached to the application is an environmental impact statement. An application for a license according to the Environmental Act (1998:808) has been submitted to the Environmental Court in Vaexjoe. SSI has circulated the application for consideration to the Swedish Nuclear Power Inspectorate, the Swedish Environmental Protection Agency, the County Government Board of Kalmar and the Oskarshamn municipality. SSI has informed the European Commission about the application in accordance with the EURATOM Treaty, article 37. This assessment report constitutes the base for the decision by SSI 2000-09-18 for approval and radiation protection conditions. In the report, earlier permissions for shallow land burials/landfills at the Swedish nuclear installations are described. This report shows the development of the legal system during the last years, the premises for the assessment of the application, and SSI's review of OKG's plans, consequence analysis and environmental impact statement

  20. Some inspirations drawn from the SKB license-application report for the construction of the final repository for spent nuclear fuel in Sweden

    International Nuclear Information System (INIS)

    Xu Guoqing

    2014-01-01

    The following problems are described in this paper: the current state of nuclear energy and spent fuel in Sweden, the brief process of repository site selection and the concise geological settings of candidate site Forsmark, the option of repository design, the data presented in license-application report on repository, construction, the review work presented by OECD/NEA international peer review team (IRT) and some considerations noted by the author: 1) Why the design of underground engineering, also known as 5 shafts + l ramp, is adopted? 2) Why the timescale for the assessment is one million years? 3) Why the computer codes used in performance assessment at Forsmark candidate repository site are different from those used at Yucca Mountain candidate repository site? 4) How to carry out the public involvement, support from local government and volumtary siting in China? 5) What is the most important in the R and D program of HLW disposal? 6) What shall we do for the future license-application report for the construction of the final repository in China? (author)

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