WorldWideScience

Sample records for biologics innovative methods

  1. Stochastic Methods in Biology

    CERN Document Server

    Kallianpur, Gopinath; Hida, Takeyuki

    1987-01-01

    The use of probabilistic methods in the biological sciences has been so well established by now that mathematical biology is regarded by many as a distinct dis­ cipline with its own repertoire of techniques. The purpose of the Workshop on sto­ chastic methods in biology held at Nagoya University during the week of July 8-12, 1985, was to enable biologists and probabilists from Japan and the U. S. to discuss the latest developments in their respective fields and to exchange ideas on the ap­ plicability of the more recent developments in stochastic process theory to problems in biology. Eighteen papers were presented at the Workshop and have been grouped under the following headings: I. Population genetics (five papers) II. Measure valued diffusion processes related to population genetics (three papers) III. Neurophysiology (two papers) IV. Fluctuation in living cells (two papers) V. Mathematical methods related to other problems in biology, epidemiology, population dynamics, etc. (six papers) An important f...

  2. Innovative methods for knowledge transfer

    Science.gov (United States)

    Goanta, A. M.

    2015-11-01

    At this time, learning takes place, either with classic books on paper support or using books scanned or drawn and further converted into PDF or PPT files that are printed on type support CD / DVD. The latter modern means of learning, the study adds live on the Internet using search engines and not least e-learning method, which allows the study of bibliographic related materials in PDF or PPT, stacked and grouped on the basis of a curriculum imposed which can be accessed on a website via a user name and password. Innovative methods come to successfully use other file types than those mentioned above. The graphics in teaching technical subjects such as descriptive geometry can be achieved using animated PowerPoint files, allowing for visualization of steps to be taken, in the case of solving by drawing a descriptive geometry. Another innovative method relies on the use of HTML files, inspired by related sites help design software packages that can be used when teaching descriptive geometry that the technical design. Through this work, the author has proposed to present a new innovative method, which is inspired by the methods listed above, but involves using AVI files to teaching of computer-assisted type graphics or info graphics. In general this new author's method lends itself particularly well to the teaching of the use of software packages because the student actually see the place from where the delivered command is accessed and contextual options of right button of the mouse. These laboratory courses or mentoring can be freestanding cards support CD / DVD or can be posted on websites with restricted access based on user name and password. Practically paper presents the methodology of creating courses and tutorials in AVI format, and how to monitor the degree of accessing the website, on which there were posted mentioned teaching materials, using the tools offered by Google Analytics. The results consist of graphical work, about the degree of access to

  3. Biological detector and method

    Energy Technology Data Exchange (ETDEWEB)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2014-04-15

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  4. Biological detector and method

    Energy Technology Data Exchange (ETDEWEB)

    Sillerud, Laurel; Alam, Todd M.; McDowell, Andrew F.

    2015-11-24

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  5. Biological detector and method

    Science.gov (United States)

    Sillerud, Laurel; Alam, Todd M; McDowell, Andrew F

    2013-02-26

    A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

  6. Synthetic biology as a source of global health innovation

    OpenAIRE

    Rooke, Jenny

    2013-01-01

    Synthetic biology has the potential to contribute breakthrough innovations to the pursuit of new global health solutions. Wishing to harness the emerging tools of synthetic biology for the goals of global health, in 2011 the Bill & Melinda Gates Foundation put out a call for grant applications to “Apply Synthetic Biology to Global Health Challenges” under its “Grand Challenges Explorations” program. A highly diverse pool of over 700 applications was received. Proposed applications of syntheti...

  7. Football refereeing: Identifying innovative methods

    Directory of Open Access Journals (Sweden)

    Reza MohammadKazemi

    2014-08-01

    Full Text Available The aim of the present study is to identify the potentials innovation in football industry. Data were collected from 10 national and international referees, assistant referees and referees’ supervisors in Iran. In this study, technological innovations are identified that assist better refereeing performances. The analysis revealed a significant relationship between using new technologies and referees ‘performance. The results indicate that elite referees, assistant referees and supervisors agreed to use new technological innovations during the game. According to their comments, this kind of technology causes the referees’ performance development.

  8. Innovations in Social Science Research Methods

    OpenAIRE

    Xenitidou, Maria; Gilbert, Nigel

    2009-01-01

    EXECUTIVE SUMMARY One of the aims of the National Centre for Research Methods (NCRM) is to identify and foster methodological innovation in the UK. The aim of this project was to identify methodological innovations outside the UK and draw NCRM’s attention to them. The project sought out research practices that have not yet filtered through to typical research methods courses or that impact on the research process in novel ways. These usually entailed (i) technological innovation, (ii) the ...

  9. Patented Biologically-inspired Technological Innovations: A Twenty Year View

    Institute of Scientific and Technical Information of China (English)

    Richard H. C. Bonser

    2006-01-01

    Publication rate of patents can be a useful measure of innovation and productivity in fields of science and technology. To assess the growth in industrially-important research, I conducted an appraisal of patents published between 1985 and 2005 on online databases using keywords chosen to select technologies arising as a result of biological inspiration. Whilst the total number of patents increased over the period examined, those with biomimetic content had increased faster as a proportion of total patent publications. Logistic regression analysis reveals that we may be a little over half way through an initial innovation cycle inspired by biological systems.

  10. Innovative methods in teaching mathematics

    OpenAIRE

    Чепелева, Т. И.

    2013-01-01

    The report outlines the main directions of innovation in the teaching of higher mathematics at the university. The basic technological approach is suggested when creating lecture presentations such as their color characteristics of fonts, the amount of information on a slide, etc., which is based on teaching experience and is suitable for development of other educational presentations.

  11. Methodical access to rating of innovation climate of region

    OpenAIRE

    Irina Golova

    2009-01-01

    The article is gives methodical access to foundation of rating indications of innovation climate of region for optimization of state management of innovation process. There are methodic and comparative analysis innovation climate in Russian regions.

  12. Standardization, IPRs and open innovation in synthetic biology

    DEFF Research Database (Denmark)

    Minssen, Timo; Wested, Jakob

    2015-01-01

    (ICT) to biological standards? These and further legal issues related to IP, regulation, standardization, competition law & open innovation require a careful consideration of new user-generated models and solutions. Before this background this paper seeks to describe IP and standardization aspects of......, in which we will address standard setting efforts in SB and the relevance of various IPRs for specific SB standards. This provides the basis for section 3, in which we debate problematic issues and summarize our conclusions....

  13. Biology technology, and innovation in high school curriculum

    Directory of Open Access Journals (Sweden)

    Antonio Carlos Rodrigues de Amorim

    1998-01-01

    Full Text Available Based on frameworks that propose the contextualization of science education centered in the science/technology/ society relationships, and on the belief that the teacher has a fundamental role on the curriculum innovation processes, this paper describes and analyses different elements of the pedagogical practice of teachers of the city of Campinas/SP, in the perspective of outlining an overview regarding the already existing biology and technology relationship. It focuses in a detailed way the conceptions of the relationships between biology and technology present in the instructional materials used or produced by teachers, describing and discussing the wide range spectrum of identified possibilities. It also emphasizes the approaches to biology and technology relationships identified by interviewing the teachers, being them similar or not to those found in the instructional materials. Indicators of the existence of a problematic theory and practice association, in which the theoretical elements (science are hierarchically superior to the practical elements (technology, were detected. This kind of association should constitute a focus of attention in the construction of innovative proposals for the biology curriculum, since science classroom discussions regarding technology – in their ethical, aesthetical, epistemological, and marketing aspects – represent an important path to dimension the biological knowledge in the capitalist contemporary society.

  14. Characterization of biologically effective UV radiation at mid-latitudes sites: innovative method for the calculation of the human vitamin D exposure

    OpenAIRE

    Modesti, Sarah

    2012-01-01

    The Italian territory has the potential for receiving high solar ultraviolet (UV) doses during most of the year. This may represent a serious hazard for human health as UV radiation is responsible for skin cancer: Italy is in the third place, after Australia and USA, for melanoma occurrences. It ought to be remember that UV radiation has well-established beneficial effects on the skin, most notably the synthesis of vitamin D3. However a climatological characterization of biologically effecti...

  15. Method for biological purification

    Science.gov (United States)

    Lucido, John A.; Keenan, Daniel; Premuzic, Eugene T.; Lin, Mow S.; Shelenkova, Ludmila

    2001-03-27

    An apparatus is disclosed for containing a microorganism culture in an active exponential growth and delivering a supply of microorganisms to an environment containing wastes for bio-augmenting the biodegradation of the wastes. The apparatus comprises a bioreactor and an operably connected controller. The bioreactor has a bioreactor chamber for containing a supply of microorganisms, a second chamber for containing a supply of water and inorganic nutrients, and a third chamber for containing a supply of organic nutrients. The bioreactor is operably connected to the controller in which a first pump is operably connected in fluid communication between the bioreactor chamber and the second chamber and third chamber, and a second pump is operably connected in fluid communication between the bioreactor chamber and the environment containing wastes to be biodegraded. The controller further includes a timer and regulator operably connected to the first and second pumps to effectively maintain the microorganisms in exponential growth in the bioreactor chamber and to deliver microorganisms to an environment to be treated. Also, disclosed is a method for bio-augmenting the biodegradation of wastes.

  16. The Quest for Innovation: Methods and Mindsets

    OpenAIRE

    Bechthold, Martin

    2015-01-01

    Innovation in the building industry has been lagging behind other fields, due in part to the fragmented nature of the field of construction, but also due to the lack of research methods that can effectively merge scientific and creative methods into a single approach. The paper discussed a novel method for interdisciplinary work at the intersection of computation, architectural design, engineering and material science. The approach was developed in the Material Processes and Systems Group at ...

  17. Innovative Techniques for Teaching Research Methods.

    Science.gov (United States)

    Babbie, Earl

    An explanation of three innovative techniques the author has used successfully to introduce undergraduate and graduate students to sociological methodology. The three methods are: (1) body-learning, which involves moving students around physically in ways analogous to the data manipulations being taught; (2) experimental learning, which involves…

  18. Jet propulsion in animals: theoretical innovation and biological constraints

    Science.gov (United States)

    Denny, Mark

    2010-11-01

    Jet propulsion is arguably the oldest and simplest form of animal locomotion, and simple hydrodynamic theory highlights the many possible ways in which animals might maximize speed and minimize metabolic cost while using jet propulsion to travel from one point to another. However, environmental and physiological reality constrains the potential for hydrodynamic innovation. We explore two heuristic examples: Antarctic scallops, in which ecological release from predation apparently constrains the evolution of improved locomotory capacity, and squids, in which the fundamental limitations of muscular contraction constrain the hydrodynamic efficiency of locomotion for all but a small range of sizes. Even simple forms of locomotion can be complex in a biological context.

  19. Business Method Patents, Innovation, and Policy

    OpenAIRE

    Hall, Bronwyn H.

    2003-01-01

    The trickle of business method patents issued by the United States Patent Office became a flood after the State Street Bank decision in 1998. Many scholars, both legal and economic, have critiqued both the quality of these patents and the decision itself. This paper discusses the likely impact of these patents on innovation. It first reviews the facts about business method and internet patents briefly and then explores what economists know about the relationship between the patent system and ...

  20. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    Energy Technology Data Exchange (ETDEWEB)

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  1. Method to detect biological particles

    International Nuclear Information System (INIS)

    A medical-diagnostic method to detect immunological as well as other specific reactions is described. According to the invention, first reactive particles (e.g. antibodies) are adsorbed on the surface of a solid, non-reactive substrate. The coated substrate is subjected to a solution which one assumes to contain the second biological particles (e.g. antigens) which are specific to the first and form complexes with these. A preferential radioactive labelling (e.g. with iodine 125) of the second biological particle is then directly or indirectly carried out. Clearage follows labelling in order to separate the second biological particles from the first ones. A specific splitting agent can selectively break the bond of both types of particle. The splitting agent solution is finally separated off and its content is investigated for the presence of labelling. (VJ)

  2. The virtue of innovation: innovation through the lenses of biological evolution

    Science.gov (United States)

    Kell, Douglas B.; Lurie-Luke, Elena

    2015-01-01

    We rehearse the processes of innovation and discovery in general terms, using as our main metaphor the biological concept of an evolutionary fitness landscape. Incremental and disruptive innovations are seen, respectively, as successful searches carried out locally or more widely. They may also be understood as reflecting evolution by mutation (incremental) versus recombination (disruptive). We also bring a platonic view, focusing on virtue and memory. We use ‘virtue’ as a measure of efforts, including the knowledge required to come up with disruptive and incremental innovations, and ‘memory’ as a measure of their lifespan, i.e. how long they are remembered. Fostering innovation, in the evolutionary metaphor, means providing the wherewithal to promote novelty, good objective functions that one is trying to optimize, and means to improve one's knowledge of, and ability to navigate, the landscape one is searching. Recombination necessarily implies multi- or inter-disciplinarity. These principles are generic to all kinds of creativity, novel ideas formation and the development of new products and technologies. PMID:25505138

  3. Innovation

    DEFF Research Database (Denmark)

    Nielsen, Janni; Yaganeh, Suzanne; Bloch Rasmussen, Leif;

    2013-01-01

    This paper contributes to a theoretical discussion of creation of innovation with participants in, or outside, organisations. We address the creation of innovation with a complex theoretical understanding drawing on the Scandinavian and the Participatory Design tradition introducing two approaches...... to the processes of innovation. We ask if innovation can be initiated and enhanced looking at two collaborative approaches; participatory innovation (PIN) and cooperative innovation (COIN). We invite to dialogue and reflections on PIN’s conflict and creative frictions on one side and COIN’s complexity......, complementarity in diversity and the didactic scaffolding of the innovation process on the other side. Our contribution focuses on the methods and practices for facilitation of co-creating activities between different groups leading to cooperation, and innovation in thinking....

  4. Innovation Policies from the European Union: Methods for Classification

    Science.gov (United States)

    Rodriguez, Victor; Montalvo, Carlos

    2007-01-01

    This study focuses on taxonomic and typological methods of innovation policies in the European institutional context. Although many types of policies affect innovation, no universally accepted criteria exist to classify them. As innovation policy in a myriad of thematic areas--systemic model--has become pluralized, this article offers a method for…

  5. Innovative teaching and learning methods in multicultural environments

    OpenAIRE

    Kakkonen, Marja-Liisa

    2014-01-01

    Teaching in higher education institutions has altered from the traditional classroom teaching more towards new types of learning methods and environments which have been under a systematic development already for several years. Nonetheless, there is still a need for new innovative solutions in the learning process and outcomes. This publication, Innovative teaching and learning methods in multicultural environment, is a part of the Nordic-Russia project which aims at promoting innovative lear...

  6. Open innovation research - emerging methods of the digital era

    OpenAIRE

    Stockinger, Hanna

    2015-01-01

    This thesis applies and develops digital open innovation research methods and thereby attempts to broaden the understanding in this emerging field. Three digital methods to foster open innovation are examined. Netnography and social media monitoring are introduced as innovative research approaches to extract and use online community dialogue for market research, marketing and product development. In addition, the development, demonstration and presentation of a novel methodological approach t...

  7. Spaces of the possible: Universal Darwinism and the wall between technological and biological innovation

    OpenAIRE

    Wagner, Andreas; Rosen, William

    2014-01-01

    Innovations in biological evolution and in technology have many common features. Some of them involve similar processes, such as trial and error and horizontal information transfer. Others describe analogous outcomes such as multiple independent origins of similar innovations. Yet others display similar temporal patterns such as episodic bursts of change separated by periods of stasis. We review nine such commonalities, and propose that the mathematical concept of a space of innovations, disc...

  8. METHODS OF EVALUATION OF THE INNOVATION POTENTIAL OF INDUSTRIAL ENTERPRISES

    Directory of Open Access Journals (Sweden)

    I. Rodionova

    2013-12-01

    Full Text Available This article reveals the problem of the analysis of the main approaches to identifying the methods of evaluation of the enterprise innovation potential and on this basis a method of evaluation of the industrial enterprise innovation potential is proposed. The article raises the issue of revealing the nature of innovation potential as the main indicator of an enterprise innovation susceptibility, and stresses that it should include such important components as manufacturing, finance, information, personnel, scientific and technology transfer. The author emphasizes the fact that in order to improve the innovation capacity of enterprises it is necessary to monitor the innovation potential and its evaluation during the implementation. Analysis of many authors who offer their own methods for assessing the innovation potential of industrial enterprises allows to make the following conclusions: 1. Identification of the managerial functions with the functions of innovation management is erroneous. Therefore, the reunion of indicators of innovative capacity, with those that characterize the results of its use leads to the existence of indicators that do not merely characterize innovation. 2. As soon as all indicators for each component of the innovation potential of enterprises are determined, the innovation potential of each component, taking into account the rating of each indicator is defined. 3. The overall innovation potential of an enterprise is the sum of all the innovation potential of its components, taking into account the rating of each component. 4. For evaluating the innovation potential of industrial enterprises it is necessary to analyze an enterprise accounting to a number of indicators – the innovation potential factors, each of which describes a component of the innovation potential. The author points out that the system of indicators used to assess the innovation potential of enterprises should contain important elements, among which

  9. Trending Approaches in Innovation Using Interdisciplinary Methods

    OpenAIRE

    Robert Cherinka; Joseph Prezzama

    2013-01-01

    This presentation presents a study of approaches to foster open innovation, including the use of crowds and social media to leverage and utilize interdisciplinary sources. Crowds are inherently interdisciplinary, and they contain experts. Wisdom can be extracted from these sources. However, the peril of bias and "group think" could be detrimental if not carefully exposed. The process of innovation benefits from a diversity of skills and perspectives. There are technology and communication tre...

  10. Successful Innovative Methods in Introducing Astronomy Courses

    Science.gov (United States)

    Chattejee, T. K. C.

    2006-08-01

    Innovating new informative methods to induce interest in students has permitted us to introduce astronomy in several universities and institutes in Mexico. As a prelude, we gave a popular course in the history of astronomy. This was very easy as astronomy seems to be the most ancient of sciences and relating the achievements of the ancient philosophers/scientists was very enlightening. Then we put up an amateur show of the sky every week (subject to climatic conditions for observability). We showed how to take photographs and make telescopic observations. We enlightened the students of the special missions of NASA and took them to museums for space exploration. We gave a popular seminar on "Astrodynamics," highlighting its importance. We gave a series of introductory talks in radio and T.V. Finally we exposed them to electronic circulars, like "Universe Today" and "World Science." The last mentioned strategy had the most electrifying effect. We may not have been successful without it, as the students began to take the matter seriously only after reading numerous electronic circulars. In this respect, these circulars are not only informative about the latest news in astronomy, but highlight the role of astronomy in the modern world. Without it, students seem to relate astronomy to astrology; it is due to this misconception that they are not attracted to astronomy. Students were hardly convinced of the need for an astronomy course, as they did not know about the scope and development of the subject. This awakened the interests of students and they themselves proposed the initiation of an elementary course in astronomy to have a feel of the subject. Later on they proposed a course on "Rocket Dynamics." We will discuss our methods and their impact in detail.

  11. Proposition of a method to formulate idea and innovation problems

    Directory of Open Access Journals (Sweden)

    Stéphane GORIA

    2010-01-01

    Full Text Available Nowadays, innovation is a major stake for development and durability of many companies and institution’s activities. In our work, we are interested in interpersonal communication problem in innovation context. We focus on the upstream of innovation process and we consider the means that can be used. First to leverage organisation’s innovation perspective and second to solve innovation problem proposed by a strategic decision maker. To do this, we believe that people charge with solving an innovation problem should manage some difficulties: to identify what can be an innovation for the decision maker, to define the objects with a big innovation potential, communicate to his possible partners the innovation field to investigate and to find ideas to innovate etc. Then, we try to identify and to present these ideas to contribute to decision making process. At this time when the Web is really the universal source with access to formidable information quantities, we use it to establish some creativity and idea sources for innovation. This paper presents a method to solve these communication problems. It presents a tool box which potentialities are illustrated by an example of the management of a “new chair” development problem.

  12. Stochastic methods of machinery enterprise endogenous innovative potential realization management

    Directory of Open Access Journals (Sweden)

    Mosin Oleksandr Oleksandrovich

    2014-12-01

    Full Text Available The aim of the article. The goal of the article is definition of effective stochastic methods of management of realization of the endogenous innovative potential (EIP of machine-building enterprise through forecasting of enterprise’s level of gross profit on the basis of values of its reserves which constitute EIP. The results of the analysis. Theoretical approaches to management of the machinery enterprise’s innovative development need to be verified by empirical researches. Evaluation of the enterprise’s innovative potential may become crucial for R&D management. Systematization and comparing methods were used to generalize ongoing approaches to enterprise innovative potential determination; deduction method was used for defining the characteristics of the machinery enterprise innovative potential. Various methods of the enterprise innovative potential development management are considered in the article. Special attention is paid to classification of approaches to definition an essence of innovative process. Development of comprehensive approach to choosing the methods of innovative potential management is based on the classification of innovations by their types. Some of the given methods can be applied to management of several types of innovations. So method of the assessment of investment efficiency indicators can be used both for management of product and technological innovations, and method of definition of a stage of innovative development can be applied for both organizational and product innovations. Thus, the scientific novelty of the research is the application of comprehensive approach to enterprise innovative potential development on the basis of allocation of types of introduced innovations and respective methods of management. At the same time further research should consider a problem of definition of an optimum ratio of quantity of introduced technological, product and organizational innovations. It is necessary to

  13. Innovation Histories: A method from learning from experience

    OpenAIRE

    Douthwaite, Boru; Ashby, Jacqueline

    2005-01-01

    Preparing an ‘innovation history’ is a method for recording and reflecting on an innovation process. People who have been involved in the innovation jointly construct a detailed written account (sometimes referred to as a ‘learning history’) based on their recollections and on available documents. The process of preparing this history stimulates discussion, reflection and learning amongst stakeholders. Subsequent planning can build on the lessons learned, formulate a shared vision and act as ...

  14. Finding Methods for Innovative Packaging Development: The Card Approach

    OpenAIRE

    Magnusson, Amanda; Olander, Malin; Olsson, Annika

    2013-01-01

    Innovation strategies are crucial for corporate success and should be a top priority for packaging companies. However, to improve the innovativeness of packaging manufacturers, there is a need to increase the integration of product and packaging development and collaboration within the supply chain. New methods for innovative packaging development are needed. Packaging plays a valuable role in the marketing and distribution of products, and can thus add great value for actors in the supply...

  15. Gamification as an Intervention Method in Practice-Based Innovation

    OpenAIRE

    Mirva Hyypiä; Satu Parjanen

    2015-01-01

    This paper concentrates on the possibilities offered by gamification in practice-based innovation activities. It addresses the following research questions: How does gamification enhance creativity in practice-based innovation? How can gamification be modified into a method that facilitates experiences of gamefulness? A case study presented in the paper examines the impact of gamification in co-creating a value-adding network for open innovation processes between organizations. The results in...

  16. Dose estimation by biological methods

    International Nuclear Information System (INIS)

    The human being is exposed to strong artificial radiation sources, mainly of two forms: the first is referred to the occupationally exposed personnel (POE) and the second, to the persons that require radiological treatment. A third form less common is by accidents. In all these conditions it is very important to estimate the absorbed dose. The classical biological dosimetry is based in the dicentric analysis. The present work is part of researches to the process to validate the In situ Fluorescent hybridation (FISH) technique which allows to analyse the aberrations on the chromosomes. (Author)

  17. Mathematical methods in biology and neurobiology

    CERN Document Server

    Jost, Jürgen

    2014-01-01

    Mathematical models can be used to meet many of the challenges and opportunities offered by modern biology. The description of biological phenomena requires a range of mathematical theories. This is the case particularly for the emerging field of systems biology. Mathematical Methods in Biology and Neurobiology introduces and develops these mathematical structures and methods in a systematic manner. It studies:   • discrete structures and graph theory • stochastic processes • dynamical systems and partial differential equations • optimization and the calculus of variations.   The biological applications range from molecular to evolutionary and ecological levels, for example:   • cellular reaction kinetics and gene regulation • biological pattern formation and chemotaxis • the biophysics and dynamics of neurons • the coding of information in neuronal systems • phylogenetic tree reconstruction • branching processes and population genetics • optimal resource allocation • sexual recombi...

  18. INNOVATIONS IN EQUIPMENT AND TECHNIQUES FOR THE BIOLOGY TEACHING LABORATORY.

    Science.gov (United States)

    BARTHELEMY, RICHARD E.; AND OTHERS

    LABORATORY TECHNIQUES AND EQUIPMENT APPROPRIATE FOR TEACHING BIOLOGICAL SCIENCE CURRICULUM STUDY BIOLOGY ARE EMPHASIZED. MAJOR CATEGORIES INCLUDE (1) LABORATORY FACILITIES, (2) EQUIPMENT AND TECHNIQUES FOR CULTURE OF MICRO-ORGANISMS, (3) LABORATORY ANIMALS AND THEIR HOUSING, (4) TECHNIQUES FOR STUDYING PLANT GROWTH, (5) TECHNIQUES FOR STUDYING…

  19. Innovative methods in teaching psychiatry to medical students

    OpenAIRE

    Antonio Lobo; Concepción de-la Cámara; Ricardo Campos; Tirso Ventura; Carlos Marco; Antonio Campayo; Federico Dourdil; Mari Fé Barcones; Pedro Saz

    2015-01-01

    Background and Objectives: To test the conjecture that the innovative method to teach psychosomatic psychiatry previously reported will be confirmed as beneficial in the training of medical students in the field of general psychiatry. Methods: The emphasis in this course is placed on the discussion of clinical cases, bed-side clinical teaching, and a research-oriented part. The “Innovative Teaching Plan” (ITP) is intended to train student-leaders to guide small groups (SG) of students. The re...

  20. Biological dosimetry - Dose estimation method using biomakers

    International Nuclear Information System (INIS)

    The individual radiation dose estimation is an important step in the radiation risk assessment. In case of radiation incident or radiation accident, sometime, physical dosimetry method can not be used for calculating the individual radiation dose, the other complement method such as biological dosimetry is very necessary. This method is based on the quantitative specific biomarkers induced by ionizing radiation, such as dicentric chromosomes, translocations, micronuclei... in human peripheral blood lymphocytes. The basis of the biological dosimetry method is the close relationship between the biomarkers and absorbed dose or dose rate; the effects of in vitro and in vivo are similar, so it is able to generate the calibration dose-effect curve in vitro for in vivo assessment. Possibilities and perspectives for performing biological dosimetry method in radiation protection area are presented in this report. (author)

  1. Structured methods for customer-oriented innovation research

    DEFF Research Database (Denmark)

    Scholderer, Joachim

    Introduction: "Being innovative is the cornerstone of sustainable competitive advantage" - as simple as this Business 101 commandment sounds, as difficult it is to comply with in practice. Most innovations fail, and more often than not the reason can be found in developers' ignorance of what...... customers might have told them if they had only properly been asked beforehand. In the following, a short introduction will be given to structured research methods that are relatively easy to use and can help product developers prioritise their efforts and assess the market potential of innovative concepts....

  2. Plant Methods: putting the spotlight on technological innovation in the plant sciences

    OpenAIRE

    Roberts Michael R; Forde Brian G

    2005-01-01

    Abstract Plant Methods is a new journal for plant biologists, specialising in the rapid publication of peer-reviewed articles with a focus on technological innovation in the plant sciences. The aim of Plant Methods is to stimulate the development and adoption of new and improved techniques and research tools in plant biology. We hope to promote more consistent standards in the plant sciences, and make readily accessible laboratory and computer-based research tools available to the whole commu...

  3. Innovative biological approaches for monitoring and improving water quality

    Directory of Open Access Journals (Sweden)

    Sanja eAracic

    2015-08-01

    Full Text Available Water quality is largely influenced by the abundance and diversity of indigenous microbes present within an aquatic environment. Physical, chemical and biological contaminants from anthropogenic activities can accumulate in aquatic systems causing detrimental ecological consequences. Approaches exploiting microbial processes are now being utilized for the detection, and removal or reduction of contaminants. Contaminants can be identified and quantified in situ using microbial whole-cell biosensors, negating the need for water samples to be tested off-site. Similarly, the innate biodegradative processes can be enhanced through manipulation of the composition and/or function of the indigenous microbial communities present within the contaminated environments. Biological contaminants, such as detrimental/pathogenic bacteria, can be specifically targeted and reduced in number using bacteriophages. This mini-review discusses the potential application of whole-cell microbial biosensors for the detection of contaminants, the exploitation of microbial biodegradative processes for environmental restoration and the manipulation of microbial communities using phages.

  4. Innovative Methods for Providing Instruction to Distance Students Using Technology.

    Science.gov (United States)

    Pival, Paul R.; Tunon, Johanna

    2001-01-01

    Examines three innovative methods tried at Nova Southeastern University for providing quality bibliographic instruction to distance students: one synchronous, one asynchronous, and one that combined features from both synchronous and asynchronous methods of delivering instruction. Topics include compressed video, collaborative groupware, streaming…

  5. Participatory methods for initiating manufacturing employees' involvement in product innovation

    DEFF Research Database (Denmark)

    Jensen, Anna Rose Vagn; Jensen, Christian Schou; Broberg, Ole

    2016-01-01

    Employee-driven innovation has the potential to improve product innovation by involving employees as innovative resources. However, it can be a challenge to turn the potential into a reality of collaboration practices across organizational structures and culture. Through an interactive research...... approach that we apply to two case companies, this paper presents an empirical study of how to initiate involvement of manufacturing employees in R&D activities. We have used participatory methods from design thinking that has the ability to create relations between employees from different backgrounds and...... through a series of facilitated workshops we have investigated how these methods can initiate employee involvement. We see that participatory methods can improve understanding and relation between R&D and manufacturing departments, and thereby support a creative collaboration and emergence of employee...

  6. Innovative training methods in business higher education

    OpenAIRE

    Arvane Vanyi, Georgina; Gal, Timea; Nabradi, Andras; Csapo, Zsolt; Peto, Karoly

    2013-01-01

    A unique business-oriented educational method was launched in 2010 at the University Of Debrecen, Hungary, in the Faculty Of Applied Economics and Rural Development; the method has existed in the JAMK University of Applied Science in Jyväskylä (Finland) since 1993, and is called Team Academy. The gist of this training is that the students learn entrepreneurship through their ‘living’ organisations with the application of the principle ‘learning-by-doing’. Besides developing the students’ entr...

  7. DNA methods: critical review of innovative approaches.

    Science.gov (United States)

    Kok, Esther J; Aarts, Henk J M; Van Hoef, A M Angeline; Kuiper, Harry A

    2002-01-01

    The presence of ingredients derived from genetically modified organisms (GMOs) in food products in the market place is subject to a number of European regulations that stipulate which product consisting of or containing GMO-derived ingredients should be labeled as such. In order to maintain these labeling requirements, a variety of different GMO detection methods have been developed to screen for either the presence of DNA or protein derived from (approved) GM varieties. Recent incidents where unapproved GM varieties entered the European market show that more powerful GMO detection and identification methods will be needed to maintain European labeling requirements in an adequate, efficient, and cost-effective way. This report discusses the current state-of-the-art as well as future developments in GMO detection. PMID:12083278

  8. Innovative methods for inorganic sample preparation

    International Nuclear Information System (INIS)

    Procedures and guidelines are given for the dissolution of a variety of selected materials using fusion, microwave, and Parr bomb techniques. These materials include germanium glass, corium-concrete mixtures, and zeolites. Emphasis is placed on sample-preparation approaches that produce a single master solution suitable for complete multielement characterization of the sample. In addition, data are presented on the soil microwave digestion method approved by the Environmental Protection Agency (EPA). Advantages and disadvantages of each sample-preparation technique are summarized

  9. Innovative methods for soil parent material mapping

    OpenAIRE

    Farewell, Timothy S.

    2010-01-01

    Soil parent material exerts a fundamental control on many environmental processes. Nevertheless, resulting from the separate mapping programmes of the geological and soil surveys, parent material is currently poorly mapped in the United Kingdom. This research develops and tests four methods of predicting soil parent material using three study areas in England. The qualities of desirable parent material maps were stated, and then used to create new map value metrics to assess th...

  10. ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: PROBLEM-SOLVING

    Directory of Open Access Journals (Sweden)

    Adela NEMEŞ

    2010-01-01

    Full Text Available We face with considerable challenge of developing students’ problem solving skills in our difficult environment. Good problem solving skills empower managers in their professional and personal lives. Problem solving skills are valued by academics and employers. The informations in Biology are often presented in abstract forms without contextualisation. Creative problem-solving process involves a few steps, which together provide a structured procedure for identifying challenges, generating ideas and implementing innovative solutions: identifying the problem, searching for possible solutions, selecting the most optimal solution and implementing a possible solution. Each aspect of personality has a different orientation to problem solving, different criteria for judging the effectiveness of the process and different associated strengths. Using real-world data in sample problems will also help facilitate the transfer process, since students can more easily identify with the context of a given situation. The paper describes the use of the Problem-Solving in Biology and the method of its administration. It also presents the results of a study undertaken to evaluate the value in teaching Biology. Problem-solving is seen as an essential skill that is developed in biology education.

  11. Innovative electron transport methods in EGS5

    International Nuclear Information System (INIS)

    The initial formulation of a Monte Carlo scheme for the transport of high-energy (>≅ 100 keV) electrons was established by Berger in 1963. Calling his method the 'condensed history theory', Berger combined the theoretical results of the previous generation of research into developing approximate solutions of the Boltzmann transport equation with numerical algorithms for exploiting the power of computers to permit iterative, piece-wise solution of the transport equation in a computationally intensive but much less approximate fashion. The methods devised by Berger, with comparatively little modification, provide the foundation of all present day Monte Carlo electron transport simulation algorithms. Only in the last 15 years, beginning with the development and publication of the PRESTA algorithm, has there been a significant revisitation of the problem of simulating electron transport within the condensed history framework. Research in this area is ongoing, highly active, and far from complete. It presents an enormous challenge, demanding derivation of new analytical transport solutions based on underlying fundamental interaction mechanisms, intuitive insight in the development of computer algorithms, and state of the art computer science skills in order to permit deployment of these techniques in an efficient manner. The EGS5 project, a modern ground-up rewrite of the EGS4 code, is now in the design phase. EGS5 will take modern photon and electron transport algorithms and deploy them in an easy-to-maintain, modern computer language-ANSI-standard C ++. Moreover, the well-known difficulties of applying EGS4 to practical geometries (geometry code development, tally routine design) should be made easier and more intuitive through the use of a visual user interface being designed by Quantum Research, Inc., work that is presented elsewhere in this conference. This report commences with a historical review of electron transport models culminating with the proposal of a

  12. Fish welfare and quality assessment by conventional and innovative methods.

    OpenAIRE

    Anna Concollato

    2015-01-01

    The overall aim of my research was on one side, to investigate the possibility of using rapid and nondestructive methods for the determination of fish fillets quality and their classification, on the other side, to find out the stunning/slaughtering method able to guarantee a minimal or to completely avoid stress condition at the moment immediately prior of the slaughtering process, by assessing the effects on fillets quality by conventional and innovative methods, from two ...

  13. Innovative Method for Saltwater Intrusion Control

    Directory of Open Access Journals (Sweden)

    Z. Payal

    2014-02-01

    Full Text Available Salt water intrusion is the migration of saltwater into freshwater aquifers under the influence of groundwater development (Freeze and Cherry, 1979. The most detrimental effect that ground water depletion causes lowering of water table. Another problem due to saltwater intrusion is changing saltwater freshwater interface. Methods for controlling intrusion vary widely depending on the source of the saline water, the extent of intrusion, local geology, water use and economic factors. The proposed methodology to control saltwater intrusion is (ADR Abstraction, Desalination and Recharge. The proposed methodology interplays between the major parameters of the system to control saltwater intrusion. These parameters include the soil/aquifer properties, the well locations, the well depths, the rates and the relation between the abstraction and recharge rates which depends on the recovery rate and the salinity degree. It is capable of completely preventing saltwater intrusion because it increases the volume of fresh groundwater and decreases the volume of saltwater, while considering economical aspects, environmental impact and sustainable development of water resources.

  14. Shoreline clean-up methods : biological treatments

    Energy Technology Data Exchange (ETDEWEB)

    Massoura, S.T. [Oil Spill Response Limited, Southampton (United Kingdom)

    2009-07-01

    The cleanup of oil spills in shoreline environments is a challenging issue worldwide. Oil spills receive public and media attention, particularly in the event of a coastal impact. It is important to evaluate the efficiency and effectiveness of cleanup methods when defining the level of effort and consequences that are appropriate to remove or treat different types of oil on different shoreline substrates. Of the many studies that have compared different mechanical, chemical and biological treatments for their effectiveness on various types of oil, biological techniques have received the most attention. For that reason, this paper evaluated the effectiveness and effects of shoreline cleanup methods using biological techniques. It summarized data from field experiments and oil spill incidents, including the Exxon Valdez, Sea Empress, Prestige, Grand Eagle, Nakhodka, Guanabara Bay and various Gulf war oil spills. Five major shoreline types were examined, notably rocky intertidal, cobble/pebble/gravel, sand/mud, saltmarsh, and mangrove/sea-grass. The biological techniques that were addressed were nutrient enrichment, hydrocarbon-utilizing bacteria, vegetable oil biosolvents, plants, surf washing, oil-particle interactions and natural attenuation. The study considered the oil type, volume and fate of stranded oil, location of coastal materials, extent of pollution and the impact of biological techniques. The main factors that affect biodegradation of hydrocarbons are the volume, chemical composition and weathering state of the petroleum product as well as the temperature, oxygen availability of nutrients, water salinity, pH level, water content, and microorganisms in the shoreline environment. The interaction of these factors also affect the biodegradation of oil. It was concluded that understanding the fate of stranded oil can help in the development of techniques that improve the weathering and degradation of oil on complex shoreline substrates. 39 refs.

  15. Comparative Method of Diagnostics of Organizational Culture of Innovative University

    OpenAIRE

    Alexander Olegovich Grudzinskiy; Olga Viktorovna Petrova

    2014-01-01

    We propose a method for diagnostics of the organizational culture of university which allows determining thereadiness of university research and teaching staff to be involved in innovation activities. This method is basedon the idea of comparing the organizational culture of the university with the organizational culture of innovativecorporations, as well as on the assessment of work motivation profile of university employees. We have selecteda "Double S Cube" – a three-dimensional model crea...

  16. Science Café Course: An Innovative Means of Improving Communication Skills of Undergraduate Biology Majors

    OpenAIRE

    Anna Goldina; Weeks, Ophelia I.

    2013-01-01

    To help bridge the increasing gap between scientists and the public, we developed an innovative two-semester course called Science Café. In this course, undergraduate biology majors learn to develop communication skills to be better able to explain science concepts and current developments in science to non-scientists. Students develop and host outreach events on various topics relevant to the community, thereby increasing interactions between budding scientists and the public. Such a Science...

  17. 2010 Diffraction Methods in Structural Biology

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Ana Gonzalez

    2011-03-10

    Advances in basic methodologies have played a major role in the dramatic progress in macromolecular crystallography over the past decade, both in terms of overall productivity and in the increasing complexity of the systems being successfully tackled. The 2010 Gordon Research Conference on Diffraction Methods in Structural Biology will, as in the past, focus on the most recent developments in methodology, covering all aspects of the process from crystallization to model building and refinement, complemented by examples of structural highlights and complementary methods. Extensive discussion will be encouraged and it is hoped that all attendees will participate by giving oral or poster presentations, the latter using the excellent poster display area available at Bates College. The relatively small size and informal atmosphere of the meeting provides an excellent opportunity for all participants, especially younger scientists, to meet and exchange ideas with leading methods developers.

  18. Graphics Innovation Design Based on Cell Intuition Simulation Method

    Institute of Scientific and Technical Information of China (English)

    XIA Zhi-qiu; REN Na; ZHAO Ting-ting; CUI Lun-feng

    2014-01-01

    This paper proposes a new cell intuition simulation method which is a combination of intuitive simulation calculation method and the operation of binary image, and applied it in the innovation of the graphic design process. First of all, we study how to express a variety of graphics, and establish the definition of cell intuitive model, work out the cell intuitive operation process and many new cellular operators such as a variety of matrix blocks crossover operator, a variety of matrix blocks mutation operator, matrix blocks replace operator, matrix blocks compression operator, matrix blocks extension operator. By choosing two or more cells and selecting the artificial selection or fitness selection, we can set up and visualize the design and pick the best design results .Finally, validation is made on this algorithm by an example, and a innovation graphic is also represented.

  19. Plant Methods: putting the spotlight on technological innovation in the plant sciences

    Directory of Open Access Journals (Sweden)

    Roberts Michael R

    2005-08-01

    Full Text Available Abstract Plant Methods is a new journal for plant biologists, specialising in the rapid publication of peer-reviewed articles with a focus on technological innovation in the plant sciences. The aim of Plant Methods is to stimulate the development and adoption of new and improved techniques and research tools in plant biology. We hope to promote more consistent standards in the plant sciences, and make readily accessible laboratory and computer-based research tools available to the whole community. This will be achieved by publishing Research articles, Methodology papers and Reviews using the BioMed Central Open Access publishing model. The journal is supported by a prestigious editorial board, whose members all recognise the importance of technological innovation as a driver for basic science.

  20. Geothermal Energy Production With Innovative Methods Of Geothermal Heat Recovery

    Energy Technology Data Exchange (ETDEWEB)

    Swenson, Allen [GeoTek Energy, LLC, Frisco, TX (United States); Darlow, Rick [GeoTek Energy, LLC, Frisco, TX (United States); Sanchez, Angel [GeoTek Energy, LLC, Frisco, TX (United States); Pierce, Michael [GeoTek Energy, LLC, Frisco, TX (United States); Sellers, Blake [GeoTek Energy, LLC, Frisco, TX (United States)

    2014-12-19

    The ThermalDrive™ Power System (“TDPS”) offers one of the most exciting technological advances in the geothermal power generation industry in the last 30 years. Using innovations in subsurface heat recovery methods, revolutionary advances in downhole pumping technology and a distributed approach to surface power production, GeoTek Energy, LLC’s TDPS offers an opportunity to change the geothermal power industry dynamics.

  1. Innovative methods in logistics and supply chain management : current issues and emerging practices

    OpenAIRE

    Hamburg International Conference of Logistics (HICL)

    2014-01-01

    Innovation is increasingly considered as an enabler of business competitive advantage. More and more organizations focus on satisfying their consumer’s demand of innovative and qualitative products and services by applying both technology-supported and non technology-supported innovative methods in their supply chain practices. Due to its very characteristic i.e. novelty, innovation is double-edged sword; capturing value from innovative methods in supply chain practices has been one of the im...

  2. ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: MODELING

    Directory of Open Access Journals (Sweden)

    Brînduşa-Antonela SBÎRCEA

    2011-01-01

    Full Text Available By using active and participatory methods it is hoped that pupils will not only come to a deeper understanding of the issues involved, but also that their motivation will be heightened. Pupil involvement in their learning is essential. Moreover, by using a variety of teaching techniques, we can help students make sense of the world in different ways, increasing the likelihood that they will develop a conceptual understanding. The teacher must be a good facilitator, monitoring and supporting group dynamics. Modeling is an instructional strategy in which the teacher demonstrates a new concept or approach to learning and pupils learn by observing. In the teaching of biology the didactic materials are fundamental tools in the teaching-learning process. Reading about scientific concepts or having a teacher explain them is not enough. Research has shown that modeling can be used across disciplines and in all grade and ability level classrooms. Using this type of instruction, teachers encourage learning.

  3. Computational methods for the innovative design of electrical devices

    Energy Technology Data Exchange (ETDEWEB)

    Wiak, Slawomir [Technical Univ. Lodz (Poland). Inst. of Mechatronics and Information; Napieralska-Juszczak, Ewa (eds.) [Univ. d' Artois, Bethune (FR). Lab. Systemes Electrotechniques et Environnement (LSEE)

    2010-07-01

    Computational Methods for the Innovative Design of Electrical Devices is entirely focused on the optimal design of various classes of electrical devices. Emerging new methods, like e.g. those based on genetic algorithms, are presented and applied in the design optimization of different devices and systems. Accordingly, the solution to field analysis problems is based on the use of finite element method, and analytical methods as well. An original aspect of the book is the broad spectrum of applications in the area of electrical engineering, especially electrical machines. This way, traditional design criteria of conventional devices are revisited in a critical way, and some innovative solutions are suggested. In particular, the optimization procedures developed are oriented to three main aspects: shape design, material properties identification, machine optimal behaviour. Topics covered include: - New parallel finite-element solvers - Response surface method - Evolutionary computing - Multiobjective optimization - Swarm intelligence - MEMS applications - Identification of magnetic properties of anisotropic laminations - Neural networks for non-destructive testing - Brushless DC motors, transformers - Permanent magnet disc motors, magnetic separators - Magnetic levitation systems (orig.)

  4. On managing innovation by design: Towards SMART methods

    NARCIS (Netherlands)

    Vermaas, P.E.

    2012-01-01

    In this paper innovation by design is characterised schematically and methodological with the aim of analysing how projects of innovation by design can be managed. First, I approach innovation by design from an engineering perspective, and show that the incorporation of innovation into design projec

  5. Network biology methods integrating biological data for translational science

    OpenAIRE

    Bebek, Gurkan; Koyutürk, Mehmet; Nathan D Price; Mark R Chance

    2012-01-01

    The explosion of biomedical data, both on the genomic and proteomic side as well as clinical data, will require complex integration and analysis to provide new molecular variables to better understand the molecular basis of phenotype. Currently, much data exist in silos and is not analyzed in frameworks where all data are brought to bear in the development of biomarkers and novel functional targets. This is beginning to change. Network biology approaches, which emphasize the interactions betw...

  6. Innovation in academic chemical screening: filling the gaps in chemical biology.

    Science.gov (United States)

    Hasson, Samuel A; Inglese, James

    2013-06-01

    Academic screening centers across the world have endeavored to discover small molecules that can modulate biological systems. To increase the reach of functional-genomic and chemical screening programs, universities, research institutes, and governments have followed their industrial counterparts in adopting high-throughput paradigms. As academic screening efforts have steadily grown in scope and complexity, so have the ideas of what is possible with the union of technology and biology. This review addresses the recent conceptual and technological innovation that has been propelling academic screening into its own unique niche. In particular, high-content and whole-organism screening are changing how academics search for novel bioactive compounds. Importantly, we recognize examples of successful chemical probe development that have punctuated the changing technology landscape. PMID:23683346

  7. Innovative methods in teaching psychiatry to medical students

    Directory of Open Access Journals (Sweden)

    Antonio Lobo

    2015-03-01

    Full Text Available Background and Objectives: To test the conjecture that the innovative method to teach psychosomatic psychiatry previously reported will be confirmed as beneficial in the training of medical students in the field of general psychiatry. Methods: The emphasis in this course is placed on the discussion of clinical cases, bed-side clinical teaching, and a research-oriented part. The “Innovative Teaching Plan” (ITP is intended to train student-leaders to guide small groups (SG of students. The results of an intensive clerkship on bedside teaching are also studied. Trainee performance was assessed by the marks in the final examination, and a reliable and valid tool, the Medical Teaching Quality Questionnaire (MTQQ was used to document trainee satisfaction. The results of five academic courses are presented in this report. Results: External experts consulted assured that the content of the course was adequate. Eight hundred and thirty eight medical students have completed the learning course in the study period, and 418 (one of the two groups completed the evaluation with the MTQQ. Most items related to the students' satisfaction were rated “high” or “very high”, including the items asking about the usefulness of the course for physicians, the quality of the teaching methods and the bedside teaching. In relation to innovation, the discussion of clinical cases in small groups was also very satisfactory and the “enhancement of a researcher's mind” was rated “high” or “very high” by 1/3rd of medical students. The utility of the yearly evaluation of the quality of teaching methods was supported by results showing that items scored not favourably in the initial evaluation were considerably improved in the follow-up evaluations, when modifications in the method were introduced. Conclusions: Good performance and high satisfaction of medical students was documented in a course on general psychiatry. Lessons may be drawn to inform about

  8. Innovation

    DEFF Research Database (Denmark)

    Helms, Niels Henrik

    2012-01-01

    Kravet om innovation og kreativitet er på flere måder en stor og en ny udfordring for voksenuddannelserne. Det udfordrer det didaktiske dilemma, det at vi skal gøres til kompetente og frie mennesker gennem pædagogiske handlinger, som netop pålægger os en ufrihed. – Men hvor denne ufrihed...... innovative, netop er det, vi endnu ikke kender...

  9. Innovative Principle and Method for Digital Jacquard Fabric Designing

    Institute of Scientific and Technical Information of China (English)

    ZHOU Jiu; NG Fran-kie; SZETO Y C; HUI C L

    2007-01-01

    Digital jacquard fabric has its design concept and method directly borrowed from computer images and color modes, which enabled creation of jacquard fabric design that is far beyond what freehand patterns can express. In this paper, the principles of digital jacquard fabric design were classified into two parts: colorless mode and colorful mode, and an innovative layered combination design method has been suggested contenting with this new design concept, by which digital jacquard fabric can be designed from colorless single-layer structure to colorful compound structure. As a result, designed colorless and colorful jacquard fabrics are capable of expressing picturesque and photo-realistic effects with a mega level color number on face of fabric. It is envisaged that the results of the study are of tremendous benefit to the creation of new jacquard fabric ith an inimitable digital effect and this creation pose no problem in mass production.

  10. Governing Methods: Policy Innovation Labs, Design and Data Science in the Digital Governance of Education

    Science.gov (United States)

    Williamson, Ben

    2015-01-01

    Policy innovation labs are emerging knowledge actors and technical experts in the governing of education. The article offers a historical and conceptual account of the organisational form of the policy innovation lab. Policy innovation labs are characterised by specific methods and techniques of design, data science, and digitisation in public…

  11. Scientific-methodical bases of management of the ecologically innovative development on different levels

    Directory of Open Access Journals (Sweden)

    T.V. Kasyanenko

    2011-01-01

    Full Text Available In the article investigation and improved essence of concept of the ecologically innovative development, aims, basic functions, principles and methods of management the ecologization of innovative development of the state, region and enterprise are certain. Intercommunication and interconsistency of management levels is formed ecologically innovative development.

  12. Methods for analysis of fluoroquinolones in biological fluids

    Science.gov (United States)

    Methods for analysis of 10 selected fluoroquinolone antibiotics in biological fluids are reviewed. Approaches for sample preparation, detection methods, limits of detection and quantitation and recovery information are provided for both single analyte and multi-analyte fluoroquinolone methods....

  13. Proceedings of the international conference on radiation biology and clinical applications: a molecular approach towards innovations in applied radiobiology and a workshop on strategies in radiation research

    International Nuclear Information System (INIS)

    Innovations in radiotherapy approaches to cancer and radiation biology research is of growing interest in radiation researchers to conduct preclinical studies at their centers and translating the results as soon as possible to clinical radiotherapy practice. Recent papers have greatly enriched the current knowledge of radiation oncology, especially radiobiology and molecular oncology, and this has radically changed the oncology practice in radiation therapy in just a few years. The conference theme highlights the molecular and cellular responses within tissue and higher levels of mammalian biological organization. New experimental radiobiology research to underpin current and future regulatory decisions setting workplace exposure limits. To develop rapid, high-precision analytical methods that assess radiation exposure doses from clinical samples and thus aid in the triage and medical management of radiological casualties. Innovative approaches to improve the accuracy, dose range, ease of use, and speed of classical biodosimetry. Papers relevant to INIS are indexed separately

  14. Supplier selection in manufacturing innovation chain-oriented public procurement based on improved PSO method

    Directory of Open Access Journals (Sweden)

    Xin Xu

    2014-01-01

    Full Text Available Purpose: At the dynamic innovation market, it is very difficult for an enterprise to accomplish innovation individually; technology innovation is shifting towards collaborative R&D chain mode. Thus, supplier selection based on individually innovation efficiency of enterprise is inapplicable to construct collaborative R&D innovation chain. This study is seeking to address how to select R&D innovation chain supplier in manufacturing industry. Design/methodology/approach: Firstly, Delphi method and AHP method are applied to establish an index system evaluating the suppliers of innovation chain, and then each index is weighted by experts with AHP method. Thirdly, optimized PSO algorithm is put forwarded based on the optimal efficiency of innovation chain to discriminate ideal suppliers meeting realistic conditions. Fourthly, innovation chain construction at generator manufacturing industry was taken as empirical case study to testify the improved PSO model. Findings: The innovation chain is comprised up by several enterprises, innovation performance of a single enterprise is not always positively correlated to that of one innovation chain, and the proposed model is capable to find out the best combination to construct an innovation chain. Research limitations/implications: The relations between these constructs with other variables of interest to the academicals fields were analyzed by a precise and credible data with a clear and concise description of the supply chain integration measurement scales. Practical implications: providing scales that are valid as a diagnostic tool for best practices, as well as providing a benchmark with which to compare the score for each individual plant against a chain of industrial innovation from machinery. Originality/value: Innovation chain integration is an important factor in explaining the innovation performance of companies. The vast range of results obtained is due to the fact that there is no exactness to

  15. Stimulating Creativity Methods And Innovative Performance In European Countries

    Directory of Open Access Journals (Sweden)

    Şipoş Gabriela Lucia

    2015-06-01

    Full Text Available A widely debated topic during the last decades focuses on the companies’ opportunities to acquire corporate competitiveness due to research, innovation and development. Thus, in the context of increased competition and current global challenges, fostering creativity and innovation is a way to boost economic growth and welfare of European countries. New and original ideas, skills, competencies and innovations they all could enable to achieve competitive advantages. Creative ideas and innovative solutions are crucial for the European countries in order to overcome the current economic crisis.

  16. Function combined method for design innovation of children's bike

    Science.gov (United States)

    Wu, Xiaoli; Qiu, Tingting; Chen, Huijuan

    2013-03-01

    As children mature, bike products for children in the market develop at the same time, and the conditions are frequently updated. Certain problems occur when using a bike, such as cycle overlapping, repeating function, and short life cycle, which go against the principles of energy conservation and the environmental protection intensive design concept. In this paper, a rational multi-function method of design through functional superposition, transformation, and technical implementation is proposed. An organic combination of frog-style scooter and children's tricycle is developed using the multi-function method. From the ergonomic perspective, the paper elaborates on the body size of children aged 5 to 12 and effectively extracts data for a multi-function children's bike, which can be used for gliding and riding. By inverting the body, parts can be interchanged between the handles and the pedals of the bike. Finally, the paper provides a detailed analysis of the components and structural design, body material, and processing technology of the bike. The study of Industrial Product Innovation Design provides an effective design method to solve the bicycle problems, extends the function problems, improves the product market situation, and enhances the energy saving feature while implementing intensive product development effectively at the same time.

  17. Methodical basis of innovative tourism products markets options determination

    OpenAIRE

    Ju.S. Miliutuna

    2012-01-01

    The article is investigated the applicability of the Frank M. Bass mathematical model to assess extent and timing of innovative tourism product consumers' perception. An author's classification of innovative tourism products target consumers is done. The necessity of Frank M. Bass model adaption to the needs of the tourism market by introducing a factor that would reflect the personal selling specifics is proved.

  18. INNOVATION

    DEFF Research Database (Denmark)

    Helms, Niels Henrik

    2012-01-01

    Kravet om innovation og kreativitet er på flere måder en stor og en ny udfordring for voksenuddannelserne. Det udfordrer det didaktiske dilemma, det at vi skal gøres til kompetente og frie mennesker gennem pædagogiske handlinger, som netop pålægger os en ufrihed. – Men hvor denne ufrihed tidligere...... kunne begrundes med, at skolen eller uddannelsen vidste bedre, så er det ikke længere tilfældet. Skolen skal sørge for, at vi lærer noget – og ikke noget andet. Men det kan ikke længere med bestemthed afgøres, hvad det er vi skal lære i skolen, fordi det nye, det kreative og ikke mindst innovative...

  19. Apparatus and Methods for Manipulation and Optimization of Biological Systems

    Science.gov (United States)

    Ho, Chih-Ming (Inventor); Wong, Pak Kin (Inventor); Sun, Ren (Inventor); Yu, Fuqu (Inventor)

    2014-01-01

    The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.

  20. Methods to Implement Innovation and Entrepreneurship in Physics

    Science.gov (United States)

    Arion, Douglas

    2015-03-01

    The physics community is beginning to become aware of the benefits of entrepreneurship and innovation education: greater enrollments, improved students satisfaction, a wider range of interesting research problems, and the potential for greater return from more successful alumni. This talk will suggest a variety of mechanisms by which physics departments can include entrepreneurship and innovation content within their programs - without necessarily requiring earth-shattering changes to the curriculum. These approaches will thus make it possible for departments to get involved with entrepreneurship and innovation, and grow those components into vibrant activities for students and faculty.

  1. Risk, creativity and ethics: dimensions of innovation in qualitative social science research methods

    OpenAIRE

    Nind, Melanie; Wiles, Rose; Bengry-Howell, Andrew; Crow, Graham

    2013-01-01

    This conference paper draws on research conducted within NCRM on the nature of methodological innovation in qualitative social science research methods, and in particular on three cases of innovation studied to explore the phenomenon in detail. The diverse cases are: netnography, child-led research and creative research. We examine the claim to a critical juncture in the emergence as innovative methods made by Robert Kozinets, Mary Kellett and David Gauntlett respectively. The research compri...

  2. Innovative method for spectral-based printer characterization

    Science.gov (United States)

    Zuffi, Silvia; Schettini, Raimondo

    2001-12-01

    The paper presents an innovative approach to the spectral-based characterization of ink-jet color printers. Our objective was to design a color separation procedure based on a spectral model of the printer, managed here as an RGB device. The printer was a four-ink device, and we assumed that the driver always replaced the black completely when converting from RGB to CMYK amounts of ink. The color separation procedure, which estimates the RGB values given a reflectance spectrum, is based on the inversion of the Yule-Nielsen modified Neugebauer model. To improve the performance of the direct Neugebauer model in computing the reflectance spectrum of the print, given the amounts of ink, we designed a method that exploits the results of the numerical inversion of the Neugebauer model to estimate a correction of the amount of black ink computed on RGB values. This correction can be considered a first step in optimization of the Neugebauer model; it accounts for ink-trapping and the lack of knowledge on how the black is actually replaced by the printer driver.

  3. Quantum integrable systems. Quantitative methods in biology

    CERN Document Server

    Feverati, Giovanni

    2011-01-01

    Quantum integrable systems have very strong mathematical properties that allow an exact description of their energetic spectrum. From the Bethe equations, I formulate the Baxter "T-Q" relation, that is the starting point of two complementary approaches based on nonlinear integral equations. The first one is known as thermodynamic Bethe ansatz, the second one as Kl\\"umper-Batchelor-Pearce-Destri- de Vega. I show the steps toward the derivation of the equations for some of the models concerned. I study the infrared and ultraviolet limits and discuss the numerical approach. Higher rank integrals of motion can be obtained, so gaining some control on the eigenvectors. After, I discuss the Hubbard model in relation to the N = 4 supersymmetric gauge theory. The Hubbard model describes hopping electrons on a lattice. In the second part, I present an evolutionary model based on Turing machines. The goal is to describe aspects of the real biological evolution, or Darwinism, by letting evolve populations of algorithms. ...

  4. Methodical basis of innovative tourism products markets options determination

    Directory of Open Access Journals (Sweden)

    Ju.S. Miliutuna

    2012-12-01

    Full Text Available The article is investigated the applicability of the Frank M. Bass mathematical model to assess extent and timing of innovative tourism product consumers' perception. An author's classification of innovative tourism products target consumers is done. The necessity of Frank M. Bass model adaption to the needs of the tourism market by introducing a factor that would reflect the personal selling specifics is proved.

  5. The banker plant method in biological control

    NARCIS (Netherlands)

    Huang, N.; Enkegaard, A.; Osborne, L.S.; Ramakers, P.M.J.; Messelink, G.J.; Pijnakker, J.; Murphy, G.

    2011-01-01

    In the banker plant method, long-lasting rearing units for beneficials are created in the crop by distributing plants infested with herbivores or carrying other food items, such as pollen. The method has been widely investigated over many years and used to aid establishment, development and dispersa

  6. An Improved Method for Completely Uncertain Biological Network Alignment

    OpenAIRE

    2015-01-01

    With the continuous development of biological experiment technology, more and more data related to uncertain biological networks needs to be analyzed. However, most of current alignment methods are designed for the deterministic biological network. Only a few can solve the probabilistic network alignment problem. However, these approaches only use the part of probabilistic data in the original networks allowing only one of the two networks to be probabilistic. To overcome the weakness of curr...

  7. Advanced Systems Biology Methods in Drug Discovery and Translational Biomedicine

    OpenAIRE

    Jun Zou; Ming-Wu Zheng; Gen Li; Zhi-Guang Su

    2013-01-01

    Systems biology is in an exponential development stage in recent years and has been widely utilized in biomedicine to better understand the molecular basis of human disease and the mechanism of drug action. Here, we discuss the fundamental concept of systems biology and its two computational methods that have been commonly used, that is, network analysis and dynamical modeling. The applications of systems biology in elucidating human disease are highlighted, consisting of human disease networ...

  8. Virtues for innovativeness : a mixed methods study of ethical organisational culture and organisational innovativeness

    OpenAIRE

    Riivari, Elina

    2016-01-01

    This study examined ethical organisational culture, consisting of ethical organisational virtues, and organisational innovativeness. More specifically, the study explored the relationship between the phenomena. Ethical organisational culture was studied using Corporate Ethical Virtues (CEV) model, which is based on the virtue theory of business ethics. This research makes a contribution to prior research on ethical organisational culture by linking the concept of organ...

  9. Science Café Course: An Innovative Means of Improving Communication Skills of Undergraduate Biology Majors

    Directory of Open Access Journals (Sweden)

    Anna Goldina

    2013-12-01

    Full Text Available To help bridge the increasing gap between scientists and the public, we developed an innovative two-semester course, called Science Café. In this course undergraduate biology majors learn to develop communication skills to be better able to explain science concepts and current developments in science to non-scientists. Students develop and host outreach events on various topics relevant to the community, thereby increasing interactions between budding scientists and the public. Such a Science Cafe course emphasizes development of science communication skills early, at the undergraduate level and empowers students to use their science knowledge in every day interactions with the public to increase science literacy, get involved in the local community and engage the public in a dialogue on various pressing science issues. We believe that undergraduate science majors can be great ambassadors for science and are often overlooked since many aspire to go on to medical/veterinary/pharmacy schools. However, science communication skills are especially important for these types of students because when they become healthcare professionals, they will interact with the public as part of their everyday jobs and can thus be great representatives for the field.

  10. Biologically Inspired Optimization Methods An Introduction

    CERN Document Server

    Wahde, M

    2008-01-01

    The advent of rapid, reliable and cheap computing power over the last decades has transformed many, if not most, fields of science and engineering. The multidisciplinary field of optimization is no exception. First of all, with fast computers, researchers and engineers can apply classical optimization methods to problems of larger and larger size. In addition, however, researchers have developed a host of new optimization algorithms that operate in a rather different way than the classical ones, and that allow practitioners to attack optimization problems where the classical methods are either

  11. Nitric oxide methods in seed biology

    Science.gov (United States)

    Nitric oxide (NO) is a gaseous, free radical that is involved in many aspects of plant growth, development, and responses to the environment. Compelling evidence points to a central role for NO in the loss of seed dormancy. NO is highly reactive, toxic at high concentrations, and unstable. Methods f...

  12. ENABLING OPEN INNOVATION PROCESS THROUGH INTERACTIVE METHODS: SCENARIOS AND GROUP DECISION SUPPORT SYSTEMS

    OpenAIRE

    JUKKA BERGMAN; ARI JANTUNEN; JUHA-MATTI SAKSA

    2009-01-01

    To be able to utilise opportunities in a radically changing business environment, various organisations are transforming their practices towards open innovation processes. Openness does not, however, mean any kind of looseness in innovation management but calls for coordination and facilitation. The challenge for the management in the open innovation process is to find out the appropriate methods and practices for the utilisation of external knowledge resources. One of the first attempts, thi...

  13. Net Present Value Approach: Method for Economic Assessment of Innovation Projects

    OpenAIRE

    Žižlavský, Ondřej

    2014-01-01

    This paper is dedicated to the issue of innovative performance measurement. It focuses on techniques that can be employed for evaluation of single innovation project. The framework is based on detailed literature review and net present value (NPV) approach analysis. Furthermore, the paper investigates its pros and cons and discusses methods able to deal with NPV weaknesses. Used with care, these techniques can guide the management of innovation project by providing indications of its potentia...

  14. Inequality in Education – Innovation in Methods: Reflections and Considerations

    OpenAIRE

    Siobhan Dytham; Carli Ria Rowell

    2015-01-01

    Against a backdrop of metamorphosis in the UK educational landscape and the increased focus on ‘innovation’ in research funding and postgraduate programmes, a conference entitled ‘Inequality in Education – Innovation in Methods’ (IEIM) was held at the University of Warwick in November 2014 to offer space to reflect on ‘inequality in education’ as a field of research and the impact, and future prospect for ‘innovation in method’ in this field. This article offers reflections and considerations...

  15. Sequential method for the assessment of innovations in computer assisted industrial processes

    International Nuclear Information System (INIS)

    A sequential method for the assessment of innovations in industrial processes is proposed, using suitable combinations of mathematical modelling and numerical simulation of dynamics. Some advantages and limitations of the proposed method are discussed. tabs

  16. Student, teaching assistant, and faculty learning during innovation in an introductory biology course

    Science.gov (United States)

    Blair, Lesley Mae

    This study examined the dynamics of student, teaching assistant (TA), and faculty learning in relationship to implementation of a genetic technologies project in a university introductory biology course. Research focused on the types of learning that occurred and the various factors impacting that learning. Study participants included 25 undergraduate non-science majors, five graduate TAs, and two faculty, including the researcher participant. Qualitative methodologies were employed to address the exploratory nature of the research questions, and included a wide variety of data collection techniques. Variables related to learning were identified and categorized to develop a hypothesis of learning in the studied course. Students, TAs, and faculty demonstrated developing diverse and remarkably similar cognitive outcomes, learning strategies, and changes within the affective domain. Differences existed in the temporal displacement of learning, as well as breadth and depth of skills and understandings. Similar internal and external factors also impacted student, TA, and faculty learning. Interactions among the three subject groups were frequent, related to common topics of interest and corrections of curricular inadequacies, and were initiated by members of each group. Emerging categories of data were developed into a hypothesis of learning which incorporated (1) the combination of pre-existing subject and situational conditions with (2) characteristics of innovation, and (3) the resulting learning community. Shifting what was being learned and how it was being taught created opportunities for conflict and uncertainty. Through resolution of these concerns, distinctions between course teachers and learners became blurred. This study suggests that all participants, with their widely varying backgrounds, interests, and abilities, contributed to development of the learning community when both content and instruction were being altered. Factors such as large class size

  17. Changing Methods and Mindsets: Lessons from Innovate NYC

    Science.gov (United States)

    Hodas, Steven

    2016-01-01

    As schools and classrooms explore technology-based, student-centered, personalized approaches to teaching and learning, their efforts to innovate can be hamstrung by archaic district operating systems that do not allow them to take advantage of new technologies, to work with smaller startup companies, or to quickly make and implement decisions.…

  18. Novel computational biology methods and their applications to drug discovery

    Institute of Scientific and Technical Information of China (English)

    Sharangdhar S. PHATAK; Hoang T. TRAN; Shuxing ZHANG

    2011-01-01

    Computational biology methods are now firmly entrenched in the drug discovery process.These methods focus on modeling and simulations of biological systems to complement and direct conventional experimental approaches.Two important branches of computational biology include protein homology modeling and the computational biophysics method of molecular dynamics.Protein modeling methods attempt to accurately predict three-dimensional (3D) structures of uncrystallized proteins for subsequent structure-based drug design applications.Molecular dynamics methods aim to elucidate the molecular motions of the static representations of crystallized protein structures.In this review we highlight recent novel methodologies in the field of homology modeling and molecular dynamics.Selected drug discovery applications using these methods conclude the review.

  19. PROMOTING BREAKTHROUGH MEDICAL INNOVATION: INSIGHTS FROM AN ANALYSIS OF RECENT TRANSFORMATIVE DRUGS, BIOLOGICS AND MEDICAL DEVICES

    OpenAIRE

    Xu, Shuai

    2014-01-01

    Given the recent concern from multiple healthcare stakeholders that the pipeline of medical innovation is slowing, this thesis provides insights on how to spur breakthrough medical innovation in present day. The findings and recommendations are derived from one of the largest collections of interview transcripts from biomedical innovators (n=143) responsible for developing critical devices, drugs and diagnostics used in medicine today. An exemplary case (coronary artery stent) was selected ...

  20. Analysis of flood modeling through innovative geomatic methods

    Science.gov (United States)

    Zazo, Santiago; Molina, José-Luis; Rodríguez-Gonzálvez, Pablo

    2015-05-01

    A suitable assessment and management of the exposure level to natural flood risks necessarily requires an exhaustive knowledge of the terrain. This study, primarily aimed to evaluate flood risk, firstly assesses the suitability of an innovative technique, called Reduced Cost Aerial Precision Photogrammetry (RC-APP), based on a motorized technology ultra-light aircraft ULM (Ultra-Light Motor), together with the hybridization of reduced costs sensors, for the acquisition of geospatial information. Consequently, this research generates the RC-APP technique which is found to be a more accurate-precise, economical and less time consuming geomatic product. This technique is applied in river engineering for the geometric modeling and risk assessment to floods. Through the application of RC-APP, a high spatial resolution image (orthophoto of 2.5 cm), and a Digital Elevation Model (DEM) of 0.10 m mesh size and high density points (about 100 points/m2), with altimetric accuracy of -0.02 ± 0.03 m have been obtained. These products have provided a detailed knowledge of the terrain, afterward used for the hydraulic simulation which has allowed a better definition of the inundated area, with important implications for flood risk assessment and management. In this sense, it should be noted that the achieved spatial resolution of DEM is 0.10 m which is especially interesting and useful in hydraulic simulations through 2D software. According to the results, the developed methodology and technology allows for a more accurate riverbed representation, compared with other traditional techniques such as Light Detection and Ranging (LiDAR), with a Root-Mean-Square Error (RMSE ± 0.50 m). This comparison has revealed that RC-APP has one lower magnitude order of error than the LiDAR method. Consequently, this technique arises as an efficient and appropriate tool, especially in areas with high exposure to risk of flooding. In hydraulic terms, the degree of detail achieved in the 3D model

  1. Application of Innovative Models in Teaching Methods for Introduction to Nature and Society and Students’ Success

    OpenAIRE

    Snezana Stavreva Veselinovska; Snezana Kirova

    2014-01-01

    This paper deals with the issue of shaping and applying innovative models in the teaching of Teaching methods for introduction to nature and society in the conditions existing in our schools. Most teachers need a modern methodical transformation of program contents for teaching nature and society. Therefore the theoretical part of the work is directed towards the consideration of innovative approaches in Teaching methods for introduction to nature and society, which asked for an indication of...

  2. Mantra to method: lessons from managing innovation on Crossrail, UK

    OpenAIRE

    DeBarro, T.; MacAulay, S.; Davies, A.; Wolstenholme, A; Gann, D.; Pelton, J.

    2015-01-01

    This paper describes how the £14·8 billion Crossrail project in London, UK developed and implemented an innovation strategy to support the delivery of the project. The strategy was designed to encourage the supply chain to develop and apply genuinely beneficial new products, processes and services − then to ensure these were shared throughout the project. The authors identify the steps taken, the managerial process created and the lessons learnt in developing and implementing the strategy. Th...

  3. Current laboratory methods for biological threat agent identification.

    Science.gov (United States)

    Henchal, E A; Teska, J D; Ludwig, G V; Shoemaker, D R; Ezzell, J W

    2001-09-01

    The authors present an integrated approach for the identification of biological threat agents. The methods used have been used extensively in field exercises and during response to incidents of biological terrorism. A diagnostic system, which integrates the clinical diagnosis or medical intelligence with immunodiagnostic tests, rapid gene amplification assays, and standard culture, provides results of the highest quality and confidence. In the future, selected reagents and technologies will be distributed through a network of civilian and military laboratories. PMID:11572145

  4. An Optimal Classification Method for Biological and Medical Data

    OpenAIRE

    Yu-Chien Ko; Hao-Chun Lu; Yao-Huei Huang

    2012-01-01

    This paper proposes a union of hyperspheres by the mixed-integer nonlinear program to classify biological and medical datasets. A classifying program with nonlinear terms uses piecewise linearization technique to obtain a global optimum. The numerical examples illustrate that the proposed method can obtain the global optimum more effectively than current methods.

  5. Alternative statistical methods for cytogenetic radiation biological dosimetry

    CERN Document Server

    Fornalski, Krzysztof Wojciech

    2014-01-01

    The paper presents alternative statistical methods for biological dosimetry, such as the Bayesian and Monte Carlo method. The classical Gaussian and robust Bayesian fit algorithms for the linear, linear-quadratic as well as saturated and critical calibration curves are described. The Bayesian model selection algorithm for those curves is also presented. In addition, five methods of dose estimation for a mixed neutron and gamma irradiation field were described: two classical methods, two Bayesian methods and one Monte Carlo method. Bayesian methods were also enhanced and generalized for situations with many types of mixed radiation. All algorithms were presented in easy-to-use form, which can be applied to any computational programming language. The presented algorithm is universal, although it was originally dedicated to cytogenetic biological dosimetry of victims of a nuclear reactor accident.

  6. Development of risk benefit structural design method for innovative reactor plants

    International Nuclear Information System (INIS)

    The development of innovative nuclear plants where the energy in the future is carried out in Japan. The design method based on a risk benefit of having maintained mitigation of a risk and the improvement in economy is called for, in order to realize the national innovative nuclear plants. Main key technologies of the risk benefit structural design method are crack propagation evaluation technology and structural reliability evaluation technology. This research aims at pulling up these two technologies on an engineering practical use level. In this paper, requirements from the design of typical innovative nuclear plants and research plan are shown.(authors)

  7. Interdisciplinary Approaches and Methods for Sustainable Transformation and Innovation

    Directory of Open Access Journals (Sweden)

    Sangkyun Kim

    2015-04-01

    Full Text Available To increase the likelihood of success and sustainability, organizations must fundamentally reposition themselves and try to change current processes or create new products and services. One of the most effective approaches to find a solution for transformation and innovation is to learn from other domains where a solution for similar problems is already available. This paper briefly introduces the definition of and approaches to convergence of academic disciplines and industries, and overviews several representative convergence cases focusing on gamification for sustainable education, environments, and business managements.

  8. Application of Innovative Models in Teaching Methods For Nature and Society Studies and Students' Success

    OpenAIRE

    Stavreva Veselinovska, Snezana; Koleva Gudeva, Liljana

    2011-01-01

    This paper deals with the issue of shaping and applying innovative models in the teaching subject Teaching methods for nature and society studies in the conditions existing in our schools. Most teachers show the need for a modern methodical transformation of program contents for teaching nature and society studies and the display of models of educational organization of classes. Therefore the theoretical part of the work is directed toward consideration of innovative approaches in Teaching me...

  9. A Biologically Inspired Model of Distributed Online Communication Supporting Efficient Search and Diffusion of Innovation

    Directory of Open Access Journals (Sweden)

    Soumya Baneerjee

    2016-01-01

    Full Text Available We inhabit a world that is not only “small” but supports efficient decentralized search – an individual using local information can establish a line of communication with another completely unknown individual. Here we augment a hierarchical social network model with communication between and within communities. We argue that organization into communities would decrease overall decentralized search times. We take inspiration from the biological immune system which organizes search for pathogens in a hybrid modular strategy. Our strategy has relevance in search for rare amounts of information in online social networks and could have implications for massively distributed search challenges. Our work also has implications for design of efficient online networks that could have an impact on networks of human collaboration, scientific collaboration and networks used in targeted manhunts. Real world systems, like online social networks, have high associated delays for long-distance links, since they are built on top of physical networks. Such systems have been shown to densify i.e. the average number of neighbours that an individual has increases with time. Hence such networks will have a communication cost due to space and the requirement of building and maintaining and increasing number of connections. We have incorporated such a non-spatial cost to communication in order to introduce the realism of individuals communicating within communities, which we call participation cost. We introduce the notion of a community size that increases with the size of the system, which is shown to reduce the time to search for information in networks. Our final strategy balances search times and participation costs and is shown to decrease time to find information in decentralized search in online social networks. Our strategy also balances strong-ties (within communities and weak-ties over long distances (between communities that bring in diverse ideas and

  10. Impacts of an Innovative Residential Construction Method on Internal Conditions

    Directory of Open Access Journals (Sweden)

    Roger Birchmore

    2015-02-01

    Full Text Available New Zealand houses are known for producing sub-optimal internal thermal conditions and unacceptably high internal moisture levels. These contribute to poor levels of health, mould and can coincide with the decay of structural timber frames. A proposed solution is to provide an alternative structure utilising plywood, a vapour check on the internal face of the timber frame and an additional air gap, followed by the internal lining. The internal vapour check is designed to prevent moisture vapour diffusion from inside into the frame and to permit moisture diffusion from outside through the structure to the internal environment. Two full scale houses had temperatures, dew points and humidity levels monitored in passive, unoccupied conditions. The test case house incorporated the innovative construction solution. The control house was of identical design and location, using standard construction practice. The calculated internal moisture content profile appeared to be unrelated to the external moisture content as expected, instead following the profile of the changing internal temperature. Whilst the innovative construction appeared to prevent moisture diffusion into the structure in winter and permit it inside in summer, this resulted in a generally higher internal relative humidity than the control house.

  11. Transforming Elementary Science Teacher Education by Bridging Formal and Informal Science Education in an Innovative Science Methods Course

    Science.gov (United States)

    Riedinger, Kelly; Marbach-Ad, Gili; McGinnis, J. Randy; Hestness, Emily; Pease, Rebecca

    2011-01-01

    We investigated curricular and pedagogical innovations in an undergraduate science methods course for elementary education majors at the University of Maryland. The goals of the innovative elementary science methods course included: improving students' attitudes toward and views of science and science teaching, to model innovative science teaching…

  12. River Pollution: Part II. Biological Methods for Assessing Water Quality.

    Science.gov (United States)

    Openshaw, Peter

    1984-01-01

    Discusses methods used in the biological assessment of river quality and such indicators of clean and polluted waters as the Trent Biotic Index, Chandler Score System, and species diversity indexes. Includes a summary of a river classification scheme based on quality criteria related to water use. (JN)

  13. Facilitating User Driven Innovation – A Study of Methods and Tools at Herlev Hospital

    DEFF Research Database (Denmark)

    Fronczek-Munter, Aneta

    Purpose: To present the preliminary research results of user driven innovation methods at healthcare facilities and their relevance to research and practice. Background/Approach: The paper is based on a case study conducted at the Gynaecologic Department at Herlev Hospital as part of Healthcare...... Innovation Lab, which is a public-private collaboration project testing the simulation and user-driven innovation between users and companies at Hospitals in the Danish Capital Region. The theories presented are user driven innovation, usability and boundary objects. Results: This article presents different...... methods used in planning of new hospital facilities and the experiences with using them in practice to improve usability of the built environment. The study focuses on the initial stages of the design processes, specially ‘user driven innovation’ – the participatory design process in which users are...

  14. Development of methods for determining aflatoxins in biological material

    OpenAIRE

    Kussak, Anders

    1995-01-01

    In this thesis, it is shown how aflatoxins can be determined in biological material. The thesis is a summary of five papers. Aflatoxins are carcinogenic mycotoxins produced by Aspergillus moulds. Methods were developed for the determination of aflatoxins in samples of airborne dust and human urine collected at feed factories. For the dust samples from such agricultural products as copra, cotton seed and maize, methods were developed for the determination of aflatoxins B1, B2, G1 and G2. For u...

  15. Using Diffusion of Innovations Theory to implement the confusion assessment method for the intensive care unit.

    Science.gov (United States)

    Bowen, Constance Mary; Stanton, Marietta; Manno, Martin

    2012-01-01

    Routine screening of mechanically ventilated patients for delirium is essential for prompt recognition and management; however, this represents a change in practice. Rogers' Diffusion of Innovations Theory can be useful as a strategy to facilitate adoption of a practice change. This case study describes the effectiveness of identifying barriers to a change in practice and developing strategies, specific to Rogers' innovation decision process, for implementing the Confusion Assessment Method for the intensive care unit. PMID:22367153

  16. Innovation Design Method for Electronic Consuming Products Figures Based on TRIZ

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    This Paper presents a valid innovation design method for electronic consuming products figures. Using the technology evaluation principle in TRIZ (theory of inventive problem solving) theory as a powerful tool, combined with consumer psychology and relevant knowledge on products modeling methodology, evolution patterns and evolution paths of electronic consuming products figures have been explored. Moreover a set of regulations working for figures innovation design is established.

  17. Biological methods used to assess surface water quality

    Directory of Open Access Journals (Sweden)

    Szczerbiñska Natalia

    2015-12-01

    Full Text Available In accordance with the guidelines of the Water Framework Directive 2000/60 (WFD, both ecological and chemical statuses determine the assessment of surface waters. The profile of ecological status is based on the analysis of various biological components, and physicochemical and hydromorphological indicators complement this assessment. The aim of this article is to present the biological methods used in the assessment of water status with a special focus on bioassay, as well as to provide a review of methods of monitoring water status. Biological test methods include both biomonitoring and bioanalytics. Water biomonitoring is used to assess and forecast the status of water. These studies aim to collect data on water pollution and forecast its impact. Biomonitoring uses organisms which are characterized by particular vulnerability to contaminants. Bioindicator organisms are algae, fungi, bacteria, larval invertebrates, cyanobacteria, macroinvertebrates, and fish. Bioanalytics is based on the receptors of contaminants that can be biologically active substances. In bioanalytics, biosensors such as viruses, bacteria, antibodies, enzymes, and biotests are used to assess degrees of pollution.

  18. [Streptokinase: correlation between different methods of biological evaluation].

    Science.gov (United States)

    Oliva, L M; Guagliardo, M V; Albertengo, M E

    1998-06-01

    A study was carried out to establish an appropriate method for streptokinase (SK) potency determination (biological assay) in order to fulfil the main function of the Instituto Nacional de Medicamentos respecting products marketed in Argentina. The potency of different commercial samples of SK was determined against the International Standard, and three internationally accepted methods were used for this purpose: fibrin plate, clot lysis and chromogenic method. The analysis of results suggests that the fibrin plate method is the least precise and reproducible. The clot lysis and chromogenic methods demonstrated great precision and reproducibility, giving a correlation coefficient of 0.99. It is concluded that both of these methods are best suited to determine potency of SK commercial products. PMID:9741232

  19. Work system innovation: Designing improvement methods for generative capability

    DEFF Research Database (Denmark)

    Hansen, David; Møller, Niels

    2013-01-01

    This paper explores how a work system’s capability for improvement is influenced by its improvement methods. Based on explorative case study at a Lean manufacturing facility, the methods problem solving and Appreciative Inquiry were compared through in-depth qualitative studies over a 12-month...... period. The findings show how problem solving leads to solutions inside the existing improvement trajectory, whereas Appreciative Inquiry due to increased generative capability enables solutions outside the existing trajectory. The paper suggests how improvement methods can be designed for appropriate...

  20. Combining various biological methods to control powdery mildew of tomato

    OpenAIRE

    Bardin, Marc; Dantony, Lea; Duffaud, Magali; Neu, Laurent; Pascal, Michel; Troulet, Claire; Nicot, Philippe

    2014-01-01

    Various biological methods, mainly based on the utilization of antagonistic microorganisms or plant extracts, have been studied to control powdery mildews. The hyperparasite fungus Ampelomyces quisqualis (AQ-10, De Sangosse) is registered in many countries to control powdery mildew on various crops, including Oidium neolycopersici on tomato in France. A plant extract from orange (Prev-Am, Vivagro) is registered to control powdery mildew and whitefly on various crops but its effect on tomat...

  1. Biclustering Methods: Biological Relevance and Application in Gene Expression Analysis

    OpenAIRE

    Ali Oghabian; Sami Kilpinen; Sampsa Hautaniemi; Elena Czeizler

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expressi...

  2. Interdisciplinary Dialogue for Education, Collaboration, and Innovation: Intelligent Biology and Medicine In and Beyond 2013

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Bing; Huang, Yufei; McDermott, Jason E.; Posey, Rebecca H.; Xu, Hua; Zhao, Zhongming

    2013-12-09

    The 2013 International Conference on Intelligent Biology and Medicine (ICIBM 2013) was held on August 11-13, 2013 in Nashville, Tennessee, USA. The conference included six scientific sessions, two tutorial sessions, one workshop, two poster sessions, and four keynote presentations that covered cutting-edge research topics in bioinformatics, systems biology, computational medicine, and intelligent computing. Here, we present a summary of the conference and an editorial report of the supplements to BMC Genomics and BMC Systems Biology that include 19 research papers selected from ICIBM 2013.

  3. INNOVATIONS AND MARKET OF BIOLOGICALLY ACTIVE SUBSTANCES IN FEEDING AND COSMETICS

    OpenAIRE

    Slaveyka Paneva; Stefan Velikov; Krasimira Markova

    2015-01-01

    This article present a model of the markets for nutritional supplements and cosmetics using as a fundamental processes of efficient coordination of activities, access to innovation, quality management through a systematic approach and strategic goal is the improvement of competitiveness. It is based on the system interoperability, which enables its integration to the common strategy and further developing. Using semantic approach allows for the integration of different systems, storage, proce...

  4. Innovative methods of correlation and orbit determination for space debris

    OpenAIRE

    Farnocchia, Davide; Tommei, Giacomo; Milani, Andrea; Rossi, Alessandro

    2010-01-01

    Abstract We propose two algorithms to provide a full preliminary orbit of an Earth-orbiting object with a number of observations lower than the classical methods, such as those by Laplace and Gauss. The first one is the Virtual debris algorithm, based upon the admissible region, that is the set of the unknown quantities corresponding to possible orbits for a given observation for objects in Earth orbit (as opposed to both interplanetary orbits and ballistic ones). A similar method ...

  5. Innovation in academic chemical screening: Filling the gaps in chemical biology

    OpenAIRE

    Hasson, Samuel A.; Inglese, James

    2013-01-01

    Academic screening centers across the world have endeavored to discover small molecules that can modulate biological systems. To increase the reach of functional-genomic and chemical screening programs, universities, research institutes, and governments have followed their industrial counterparts in adopting high-throughput paradigms. As academic screening efforts have steadily grown in scope and complexity, so have the ideas of what is possible with the union of technology and biology. This ...

  6. Innovative transient-proof hydrostatic level measuring method

    International Nuclear Information System (INIS)

    Most of the level monitoring systems for pressure vessels containing saturated steam-water mixture use the hydrostatic method. Differential pressure transducers are connected by pulse tubes with nozzles at different height of the pressure vessel. A disadvantage of this method is given by measuring errors caused by evaporation and/or degassing processes in vertical parts of these pulse lines. The error is caused by the decrease of the fluid density in the reference pipe, when a two-phase mixture appears. The present work aimed at the test of a novel differential pressure measuring system that eliminates the influence of density changes in the pulse lines. It is based on two differential pressure transducers, placed accurately at the elevation of the connecting nozzles. They are connected with the pressure vessel only by horizontal pipes. The vertical distance is bridged by a standpipe, the fluid of which is completely separated from the fluid in the vessel. Degassing respectively evaporation effects can therefore be completely excluded in the reference column of the new system. The method was tested at the pressurizer test facility of the University of Applied Sciences Zittau/Goertlitz, IPM on three types of transients including a rapid pressure decrease similar to a loss-of-coolant transient. Traditional differential pressure systems as well as local void probes were used for comparison. The method has proven its advantages compared to the traditional hydrostatic level measurement method. (orig.)

  7. A poroelastic immersed boundary method with applications to cell biology

    Science.gov (United States)

    Strychalski, Wanda; Copos, Calina A.; Lewis, Owen L.; Guy, Robert D.

    2015-02-01

    The immersed boundary method is a widely used mixed Eulerian/Lagrangian framework for simulating the motion of elastic structures immersed in viscous fluids. In the traditional immersed boundary method, the fluid and structure move with the same velocity field. In this work, a model based on the immersed boundary method is presented for simulating poroelastic media in which the fluid permeates a porous, elastic structure of small volume fraction that moves with its own velocity field. Two distinct methods for calculating elastic stresses are presented and compared. The methods are validated on a radially symmetric test problem by comparing with a finite difference solution of the classical equations of poroelasticity. Finally, two applications of the modeling framework to cell biology are provided: cellular blebbing and cell crawling. It is shown that in both examples, poroelastic effects are necessary to explain the relevant mechanics.

  8. Method and apparatus to image biological interactions in plants

    Science.gov (United States)

    Weisenberger, Andrew; Bonito, Gregory M.; Reid, Chantal D.; Smith, Mark Frederick

    2015-12-22

    A method to dynamically image the actual translocation of molecular compounds of interest in a plant root, root system, and rhizosphere without disturbing the root or the soil. The technique makes use of radioactive isotopes as tracers to label molecules of interest and to image their distribution in the plant and/or soil. The method allows for the study and imaging of various biological and biochemical interactions in the rhizosphere of a plant, including, but not limited to, mycorrhizal associations in such regions.

  9. Methods of 15N tracer research in biological systems

    International Nuclear Information System (INIS)

    The application of the stable isotope 15N is of increasing importance in different scientific disciplines, especially in medicine, agriculture, and the biosciences. The close correlation between the growing interest and improvements of analytical procedures resulted in remarkable advances in the 15N tracer technique. On the basis of the latest results of 15N tracer research in life sciences and agriculture methods of 15N tracer research in biological systems are compiled. The 15N methodology is considered under three headings: Chemical analysis with a description of methods of sample preparation (including different separation and isolation methods for N-containing substances of biological and agricultural origin) and special procedures converting ammonia to molecular nitrogen. Isotopic analysis with a review on the most important methods of isotopic analysis of nitrogen: mass spectrometry (including the GC-MS technique), emission spectrometry, NMR spectroscopy, and other analytical procedures. 15N-tracer techniques with a consideration of the role of the isotope dilution analysis as well as different labelling techniques and the mathematical interpretation of tracer data (modelling, N turnover experiments). In these chapters also sources of errors in chemical and isotopic analysis, the accuracy of the different methods and its importance on tracer experiments are discussed. Procedures for micro scale 15N analysis and aspects of 15N analysis on the level of natural abundance are considered. Furthermore some remarks on isotope effects in 15N tracer experiments are made. (author)

  10. The Elnady Technique: An innovative, new method for tissue preservation.

    Science.gov (United States)

    Elnady, Fawzy A

    2016-01-01

    At the Faculty of Veterinary Medicine, Cairo University, there is an increasing number of students but a limited availability of animal cadavers used for dissection, and student exposure to formalin is a known hazard. In order to address these challenges, a new method for tissue preservation was developed, the "Elnady Technique." This method is a modified form of plastination, where the chemicals used are not patented, are inexpensive and locally available, and the process is performed at room temperature. The produced specimens are realistic, durable, have no offensive odor, and are dry, soft and flexible. They can be used to replace the use of animals killed for teaching basic anatomy, embryology, pathology, parasitology and forensic medicine. They have great potential to support training in clinical skills and surgery, including for clinical examination, endoscopy, surgical sutures, and obstetrics simulation. PMID:26821550

  11. An innovative method for simulating microgravity effects through combining electromagnetic force and buoyancy

    Science.gov (United States)

    Yuan, Jianping; Zhu, Zhanxia; Ming, Zhenfeng; Luo, Qiuyue

    2015-07-01

    This paper proposes an innovative method for simulating space microgravity effects. The new approach combines the neutral buoyancy and the electromagnetic force on the tested-body to balance the gravity and simulate the microgravity effects. In the paper, we present in some detail the magnetism-buoyancy hybrid microgravity simulation system, its components, functions and verification. We describe some key techniques such as ground-space similarity, the homogenization of electromagnetic field, the precise control of microgravity effects in dynamic environment, measurement in the hybrid suspension system. With this innovative microgravity simulation system, we prove through experiments and tests that our innovative method is feasible and effective and that the simulation fidelity is even higher than the neutral buoyancy system.

  12. Descriptive Analysis of the Regional Innovation System - Novel Method for Public Administration Authorities

    Directory of Open Access Journals (Sweden)

    Katerina MATATKOVA

    2013-06-01

    Full Text Available Making innovation is currently one of the key factors of economic development, both for the private sector and the public sector. The public sector can help to support the effective form of knowledge creation and development that will lead to real innovations in the administrated region. Innovations can help meet the objectives of public policies (such as the creation of new jobs and support small and medium-sized enterprises, etc.. This paper tries to summarize the findings regarding knowledge and the innovation environment that public authorities can support in the form of regional innovation systems (RIS. Authors suggest a novel method for increasing efficiency of public financial support. This method was proven in RIS research in the Czech Republic, where the strategic documents initiating support RIS were created. The authors discuss the characters which adequately describe RIS. The added value of this paper is represented by the methodology of RIS describing and listing the public authorities’ roles in establishing a knowledge environment.

  13. Biclustering methods: biological relevance and application in gene expression analysis.

    Science.gov (United States)

    Oghabian, Ali; Kilpinen, Sami; Hautaniemi, Sampsa; Czeizler, Elena

    2014-01-01

    DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering) methods where genes (or respectively samples) are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes). An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical) methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1) we examine how well the considered (bi)clustering methods differentiate various sample types; (2) we evaluate how well the groups of genes discovered by the (bi)clustering methods are annotated with similar Gene Ontology categories; (3) we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4) we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples. PMID:24651574

  14. Biclustering methods: biological relevance and application in gene expression analysis.

    Directory of Open Access Journals (Sweden)

    Ali Oghabian

    Full Text Available DNA microarray technologies are used extensively to profile the expression levels of thousands of genes under various conditions, yielding extremely large data-matrices. Thus, analyzing this information and extracting biologically relevant knowledge becomes a considerable challenge. A classical approach for tackling this challenge is to use clustering (also known as one-way clustering methods where genes (or respectively samples are grouped together based on the similarity of their expression profiles across the set of all samples (or respectively genes. An alternative approach is to develop biclustering methods to identify local patterns in the data. These methods extract subgroups of genes that are co-expressed across only a subset of samples and may feature important biological or medical implications. In this study we evaluate 13 biclustering and 2 clustering (k-means and hierarchical methods. We use several approaches to compare their performance on two real gene expression data sets. For this purpose we apply four evaluation measures in our analysis: (1 we examine how well the considered (biclustering methods differentiate various sample types; (2 we evaluate how well the groups of genes discovered by the (biclustering methods are annotated with similar Gene Ontology categories; (3 we evaluate the capability of the methods to differentiate genes that are known to be specific to the particular sample types we study and (4 we compare the running time of the algorithms. In the end, we conclude that as long as the samples are well defined and annotated, the contamination of the samples is limited, and the samples are well replicated, biclustering methods such as Plaid and SAMBA are useful for discovering relevant subsets of genes and samples.

  15. TQWT and WDGA: innovative methods for ground roll attenuation

    International Nuclear Information System (INIS)

    The existence of noise in seismic data has an undesirable effect on seismic interpretations. An important type of coherent noise is ground roll, in which time and frequency overlap with useful seismic signals. The tunable Q-factor wavelet transform is a new discrete wavelet transform method and is considered as a new tool for ground roll attenuation. The simple tunable Q-factor wavelet transform by using a single wavelet with explicit oscillatory behavior is utilized for each trace. The enhanced tunable Q-factor wavelet transform (for seismic signals), which benefits from several mother wavelets with distinct Q-factors (for each part of a signal), is presented here and it is shown that it can adjust reliably to the natural non-stationary behavior of a seismic signal in time and space. Random noise has an undesirable effect on Q-factor ranges, with extreme consequences. Wavelet domain ground roll analysis is used as a substitute approach to thresholding for ground roll attenuation. The simple tunable Q-factor wavelet transform and the enhanced tunable Q-factor wavelet transform are compared with each other and with the f-k method by using synthetic and real data samples. (paper)

  16. An Innovative Operative Method for Correction of Tracheal Stenosis.

    Science.gov (United States)

    Shah, Dakshesh R; Mungutwar, Varsha

    2016-09-01

    This is a case of failed attempt of hanging, resulted into cervical injury & injury to the trachea. Patient was put on the ventilator for respiratory support for long period. Poor recovery of the patient resulted into prolong tracheostomy tube. Combine effect of all resulted into suprastomal tracheal stenosis. Due to complexity of the problem a novel method was customized to correct the tracheal stenosis. Strap muscle (Sternohyoid & Sternothyroid) was raised as a flap; free cartilage was sandwiched in between and sutured to the created tracheal defect. Bovine collagen was placed over a stent and placed in the tracheal lumen. Good result was achieved post operatively in the form of adequate lumen, rigid anterior wall during respiration, good mucosal lining without fibrosis and normal speech. PMID:27508127

  17. Implementation of an Innovative Method to Design Reflectarray Antennas

    Directory of Open Access Journals (Sweden)

    Abdelhamid Tayebi

    2012-01-01

    Full Text Available A novel computed aided technique for designing reflectarray antennas is presented. The developed approach automatically generates the geometrical model of reflectarray antennas taking into account some input parameters, such as, the unit cell type and dimensions, frequency, focal length, periodicity, dielectric materials, and desired main beam radiating direction. The characteristics of the reflecting elements are selected considering the spatial phase delay at each unit cell to achieve a progressive phase shift. The implemented procedure also provides the phase characteristic of the unit element, which is rapidly computed by using a parallelized Moment Method (MoM approach. The MoM is also used to obtain the radiation pattern of the full reflectarray antenna. In order to evaluate the new technique, a dual-interface prototype has been designed and simulated showing high-performance capability.

  18. Impact of method of business system integration to business space on innovative strategy choice

    Directory of Open Access Journals (Sweden)

    L.K. Glinenko

    2011-12-01

    Full Text Available Existing typology of methods of business system integration to business space and interdependences between the method of integration, type of development strategy, integration and innovative strategy are studied. The matrix of mutual accordance of these strategies and methods of integration of business system into business space is developed. Application of the matrix can efficiently support the forming of the agreed non-contradictory set of strategies.

  19. Impact of method of business system integration to business space on innovative strategy choice

    OpenAIRE

    L.K. Glinenko

    2011-01-01

    Existing typology of methods of business system integration to business space and interdependences between the method of integration, type of development strategy, integration and innovative strategy are studied. The matrix of mutual accordance of these strategies and methods of integration of business system into business space is developed. Application of the matrix can efficiently support the forming of the agreed non-contradictory set of strategies.

  20. An Innovative, Effective and Cost Effective Survey Method Using a Survey-Check Response Format

    OpenAIRE

    Feil, Edward G; Severson, Herbert; Taylor, Ted; Boles, Shawn; Albert, David A.; Blair, Jason

    2006-01-01

    Maximizing the response rate to surveys involves thoughtful choices about survey design, sampling and collection methods. This paper describes an innovative survey method, to provide immediate reinforcement for responding and to minimize the response cost. This method involves using a questionnaire printed as checks on security (anti-fraud) paper with questions and responses separated using a perforated tear off section. Once a participant completes the survey, the response area is detached f...

  1. Comparing results of cultured and uncultured biological methods used in biological phosphorus removal

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Increasing attention has been paid to phosphate-accumulating organisms (PAOs) for their important role in biological phosphorus removal. In this study, microbial communities of PAOs cultivated under different carbon sources (sewage, glucose, and sodium acetate) were investigated and compared through culture-dependent and culture-independent methods, respectively. The results obtained using denaturing gradient gel electrophoresis (DGGE) of polymerase chain reaction-amplified 16S rDNA fragments revealed that the diversity of bacteria in a sewage-fed reactor (1#) was much higher than in a glucose-fed one (2#) and a sodium acetate-fed one (3#); there were common PAOs in three reactors fed by different carbon sources. Five strains were separated from three systems by using a phosphate-rich medium; they were from common bacteria isolated and three isolates could not be found in DGGE profile at all. Two isolates had good phosphorus removal ability. When the microbial diversity was studied, the molecular biological method was better than the culture-dependent one. When phosphorus removal characteristics were investigated, culture-dependent approach was more effective. Thus a combination of two methods is necessary to have a comprehensive view of PAOs.

  2. Biological methods of dye removal from textile effluents - A review

    Directory of Open Access Journals (Sweden)

    Archna *

    2012-08-01

    Full Text Available Textile dyes are molecules designed to impart permanent colours to textile fabrics. They pose an environmental problem due to their toxicity and decrease the aesthetic value of water bodies into which they are discharged. Current physico-chemical technologies for dye removal cannot remove all classes of dyes, and two or more technologies are usually combined to achieve satisfactory decolourisation efficiencies. Direct biological treatment using fungi or bacteria can also be employed, but nutritional and physiological requirements of microorganisms put constraints on the applicability of such bioremediation processes. The search for efficient and green oxidation technologies has increased the interest in the use of enzymes to replace the conventional non-biological methods. Among the different existing oxidant enzymes, laccase (benzenediol:oxygen oxidoreductases; EC 1.10.3.2 has been the subject of intensive research in the past few decades due to its low substrate specificity. Enzymatic treatment using laccase can be simpler and much more efficient than the traditional physical or chemical treatments. This paper reviews conventional biological processes as well as  laccase-based processes might replace the traditionally energy intensive and water-consuming chemical treatment operations in the textile industry. Keywords: Dyes, Decolourisation, Green Oxidation, Laccase, Textile industry  

  3. Key Competencies and Characteristics for Innovative Teaching among Secondary School Teachers: A Mixed-Methods Research

    Science.gov (United States)

    Zhu, Chang; Wang, Di

    2014-01-01

    This research aims to understand the key competencies and characteristics for innovative teaching as perceived by Chinese secondary teachers. A mixed-methods research was used to investigate secondary teachers' views. First, a qualitative study was conducted with interviews of teachers to understand the perceived key competencies and…

  4. Developing Critical Understanding in HRM Students: Using Innovative Teaching Methods to Encourage Deep Approaches to Study

    Science.gov (United States)

    Butler, Michael J. R.; Reddy, Peter

    2010-01-01

    Purpose: This paper aims to focus on developing critical understanding in human resource management (HRM) students in Aston Business School, UK. The paper reveals that innovative teaching methods encourage deep approaches to study, an indicator of students reaching their own understanding of material and ideas. This improves student employability…

  5. Modeling technology innovation: How science, engineering, and industry methods can combine to generate beneficial socioeconomic impacts

    Directory of Open Access Journals (Sweden)

    Stone Vathsala I

    2012-05-01

    Full Text Available Abstract Background Government-sponsored science, technology, and innovation (STI programs support the socioeconomic aspects of public policies, in addition to expanding the knowledge base. For example, beneficial healthcare services and devices are expected to result from investments in research and development (R&D programs, which assume a causal link to commercial innovation. Such programs are increasingly held accountable for evidence of impact—that is, innovative goods and services resulting from R&D activity. However, the absence of comprehensive models and metrics skews evidence gathering toward bibliometrics about research outputs (published discoveries, with less focus on transfer metrics about development outputs (patented prototypes and almost none on econometrics related to production outputs (commercial innovations. This disparity is particularly problematic for the expressed intent of such programs, as most measurable socioeconomic benefits result from the last category of outputs. Methods This paper proposes a conceptual framework integrating all three knowledge-generating methods into a logic model, useful for planning, obtaining, and measuring the intended beneficial impacts through the implementation of knowledge in practice. Additionally, the integration of the Context-Input-Process-Product (CIPP model of evaluation proactively builds relevance into STI policies and programs while sustaining rigor. Results The resulting logic model framework explicitly traces the progress of knowledge from inputs, following it through the three knowledge-generating processes and their respective knowledge outputs (discovery, invention, innovation, as it generates the intended socio-beneficial impacts. It is a hybrid model for generating technology-based innovations, where best practices in new product development merge with a widely accepted knowledge-translation approach. Given the emphasis on evidence-based practice in the medical and

  6. Biological Stability of Drinking Water: Controlling Factors, Methods, and Challenges

    KAUST Repository

    Prest, Emmanuelle I.

    2016-02-01

    Biological stability of drinking water refers to the concept of providing consumers with drinking water of same microbial quality at the tap as produced at the water treatment facility. However, uncontrolled growth of bacteria can occur during distribution in water mains and premise plumbing, and can lead to hygienic (e.g., development of opportunistic pathogens), aesthetic (e.g., deterioration of taste, odor, color) or operational (e.g., fouling or biocorrosion of pipes) problems. Drinking water contains diverse microorganisms competing for limited available nutrients for growth. Bacterial growth and interactions are regulated by factors, such as (i) type and concentration of available organic and inorganic nutrients, (ii) type and concentration of residual disinfectant, (iii) presence of predators, such as protozoa and invertebrates, (iv) environmental conditions, such as water temperature, and (v) spatial location of microorganisms (bulk water, sediment, or biofilm). Water treatment and distribution conditions in water mains and premise plumbing affect each of these factors and shape bacterial community characteristics (abundance, composition, viability) in distribution systems. Improved understanding of bacterial interactions in distribution systems and of environmental conditions impact is needed for better control of bacterial communities during drinking water production and distribution. This article reviews (i) existing knowledge on biological stability controlling factors and (ii) how these factors are affected by drinking water production and distribution conditions. In addition, (iii) the concept of biological stability is discussed in light of experience with well-established and new analytical methods, enabling high throughput analysis and in-depth characterization of bacterial communities in drinking water. We discussed, how knowledge gained from novel techniques will improve design and monitoring of water treatment and distribution systems in order

  7. Biological Stability of Drinking Water: Controlling Factors, Methods, and Challenges

    Science.gov (United States)

    Prest, Emmanuelle I.; Hammes, Frederik; van Loosdrecht, Mark C. M.; Vrouwenvelder, Johannes S.

    2016-01-01

    Biological stability of drinking water refers to the concept of providing consumers with drinking water of same microbial quality at the tap as produced at the water treatment facility. However, uncontrolled growth of bacteria can occur during distribution in water mains and premise plumbing, and can lead to hygienic (e.g., development of opportunistic pathogens), aesthetic (e.g., deterioration of taste, odor, color) or operational (e.g., fouling or biocorrosion of pipes) problems. Drinking water contains diverse microorganisms competing for limited available nutrients for growth. Bacterial growth and interactions are regulated by factors, such as (i) type and concentration of available organic and inorganic nutrients, (ii) type and concentration of residual disinfectant, (iii) presence of predators, such as protozoa and invertebrates, (iv) environmental conditions, such as water temperature, and (v) spatial location of microorganisms (bulk water, sediment, or biofilm). Water treatment and distribution conditions in water mains and premise plumbing affect each of these factors and shape bacterial community characteristics (abundance, composition, viability) in distribution systems. Improved understanding of bacterial interactions in distribution systems and of environmental conditions impact is needed for better control of bacterial communities during drinking water production and distribution. This article reviews (i) existing knowledge on biological stability controlling factors and (ii) how these factors are affected by drinking water production and distribution conditions. In addition, (iii) the concept of biological stability is discussed in light of experience with well-established and new analytical methods, enabling high throughput analysis and in-depth characterization of bacterial communities in drinking water. We discussed, how knowledge gained from novel techniques will improve design and monitoring of water treatment and distribution systems in order

  8. Biological Stability of Drinking Water: Controlling Factors, Methods, and Challenges.

    Science.gov (United States)

    Prest, Emmanuelle I; Hammes, Frederik; van Loosdrecht, Mark C M; Vrouwenvelder, Johannes S

    2016-01-01

    Biological stability of drinking water refers to the concept of providing consumers with drinking water of same microbial quality at the tap as produced at the water treatment facility. However, uncontrolled growth of bacteria can occur during distribution in water mains and premise plumbing, and can lead to hygienic (e.g., development of opportunistic pathogens), aesthetic (e.g., deterioration of taste, odor, color) or operational (e.g., fouling or biocorrosion of pipes) problems. Drinking water contains diverse microorganisms competing for limited available nutrients for growth. Bacterial growth and interactions are regulated by factors, such as (i) type and concentration of available organic and inorganic nutrients, (ii) type and concentration of residual disinfectant, (iii) presence of predators, such as protozoa and invertebrates, (iv) environmental conditions, such as water temperature, and (v) spatial location of microorganisms (bulk water, sediment, or biofilm). Water treatment and distribution conditions in water mains and premise plumbing affect each of these factors and shape bacterial community characteristics (abundance, composition, viability) in distribution systems. Improved understanding of bacterial interactions in distribution systems and of environmental conditions impact is needed for better control of bacterial communities during drinking water production and distribution. This article reviews (i) existing knowledge on biological stability controlling factors and (ii) how these factors are affected by drinking water production and distribution conditions. In addition, (iii) the concept of biological stability is discussed in light of experience with well-established and new analytical methods, enabling high throughput analysis and in-depth characterization of bacterial communities in drinking water. We discussed, how knowledge gained from novel techniques will improve design and monitoring of water treatment and distribution systems in order

  9. Biological stability of drinking water: controlling factors, methods and challenges

    Directory of Open Access Journals (Sweden)

    Emmanuelle ePrest

    2016-02-01

    Full Text Available Biological stability of drinking water refers to the concept of providing consumers with drinking water of same microbial quality at the tap as produced at the water treatment facility. However, uncontrolled growth of bacteria can occur during distribution in water mains and premise plumbing, and can lead to hygienic (e.g. development of opportunistic pathogens, aesthetic (e.g. deterioration of taste, odour, colour or operational (e.g. fouling or biocorrosion of pipes problems. Drinking water contains diverse microorganisms competing for limited available nutrients for growth. Bacterial growth and interactions are regulated by factors such as (i type and concentration of available organic and inorganic nutrients, (ii type and concentration of residual disinfectant, (iii presence of predators such as protozoa and invertebrates, (iv environmental conditions such as water temperature, and (v spatial location of microorganisms (bulk water, sediment or biofilm. Water treatment and distribution conditions in water mains and premise plumbing affect each of these factors and shape bacterial community characteristics (abundance, composition, viability in distribution systems. Improved understanding of bacterial interactions in distribution systems and of environmental conditions impact is needed for better control of bacterial communities during drinking water production and distribution. This article reviews (i existing knowledge on biological stability controlling factors and (ii how these factors are affected by drinking water production and distribution conditions. In addition, (iii the concept of biological stability is discussed in light of experience with well-established and new analytical methods, enabling high throughput analysis and in-depth characterization of bacterial communities in drinking water. We discuss how knowledge gained from novel techniques will improve design and monitoring of water treatment and distribution systems in order to

  10. Methods and models in mathematical biology deterministic and stochastic approaches

    CERN Document Server

    Müller, Johannes

    2015-01-01

    This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models, and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks, and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and  branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models.

  11. Innovation in biological production and upgrading of methane and hydrogen for use as gaseous transport biofuel.

    Science.gov (United States)

    Xia, Ao; Cheng, Jun; Murphy, Jerry D

    2016-01-01

    Biofuels derived from biomass will play a major role in future renewable energy supplies in transport. Gaseous biofuels have superior energy balances, offer greater greenhouse gas emission reductions and produce lower pollutant emissions than liquid biofuels. Biogas derived through fermentation of wet organic substrates will play a major role in future transport systems. Biogas (which is composed of approximately 60% methane/hydrogen and 40% carbon dioxide) requires an upgrading process to reduce the carbon dioxide content to less than 3% before it is used as compressed gas in transport. This paper reviews recent developments in fermentative biogas production and upgrading as a transport fuel. Third generation gaseous biofuels may be generated using marine-based algae via two-stage fermentation, cogenerating hydrogen and methane. Alternative biological upgrading techniques, such as biological methanation and microalgal biogas upgrading, have the potential to simultaneously upgrade biogas, increase gaseous biofuel yield and reduce carbon dioxide emission. PMID:26724182

  12. A Biologically Inspired Model of Distributed Online Communication Supporting Efficient Search and Diffusion of Innovation

    OpenAIRE

    Soumya Baneerjee

    2016-01-01

    We inhabit a world that is not only “small” but supports efficient decentralized search – an individual using local information can establish a line of communication with another completely unknown individual. Here we augment a hierarchical social network model with communication between and within communities. We argue that organization into communities would decrease overall decentralized search times. We take inspiration from the biological immune system which organizes search for pathogen...

  13. Biological characteristics of crucian by quantitative inspection method

    Science.gov (United States)

    Chu, Mengqi

    2015-04-01

    Biological characteristics of crucian by quantitative inspection method Through quantitative inspection method , the biological characteristics of crucian was preliminary researched. Crucian , Belongs to Cypriniformes, Cyprinidae, Carassius auratus, is a kind of main plant-eating omnivorous fish,like Gregarious, selection and ranking. Crucian are widely distributed, perennial water all over the country all have production. Determine the indicators of crucian in the experiment, to understand the growth, reproduction situation of crucian in this area . Using the measured data (such as the scale length ,scale size and wheel diameter and so on) and related functional to calculate growth of crucian in any one year.According to the egg shape, color, weight ,etc to determine its maturity, with the mean egg diameter per 20 eggs and the number of eggs per 0.5 grams, to calculate the relative and absolute fecundity of the fish .Measured crucian were female puberty. Based on the relation between the scale diameter and length and the information, linear relationship between crucian scale diameter and length: y=1.530+3.0649. From the data, the fertility and is closely relative to the increase of age. The older, the more mature gonad development. The more amount of eggs. In addition, absolute fecundity increases with the pituitary gland.Through quantitative check crucian bait food intake by the object, reveals the main food, secondary foods, and chance food of crucian ,and understand that crucian degree of be fond of of all kinds of bait organisms.Fish fertility with weight gain, it has the characteristics of species and populations, and at the same tmes influenced by the age of the individual, body length, body weight, environmental conditions (especially the nutrition conditions), and breeding habits, spawning times factors and the size of the egg. After a series of studies of crucian biological character, provide the ecological basis for local crucian's feeding, breeding

  14. Innovation methods integration for safety conflicts management in design Case study : the three-point hitch

    OpenAIRE

    Ghemraoui, R.; Mathieu, L.; Tricot, N.

    2010-01-01

    This paper looks at the problem of taking safety requirements into account in the agricultural equipment design thanks to the integration of innovation theories and methods. Firstly, it goes to introduce two major methods, Axiomatic Design and TRIZ, which have been applied in other transportation domains and have given successful results. Currently, Axiomatic Design is used to analyse the technical product and to point out technical problems. Based on two design axioms, Axiomatic Design is a ...

  15. Methods of biological dosimetry employing chromosome-specific staining

    Science.gov (United States)

    Gray, Joe W.; Pinkel, Daniel

    2000-01-01

    Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods are provided to disable the hybridization capacity of shared, high copy repetitive sequences and/or remove such sequences to provide for useful contrast. Still further methods are provided to produce chromosome-specific staining reagents which are made specific to the targeted chromosomal material, which can be one or more whole chromosomes, one or more regions on one or more chromosomes, subsets of chromosomes and/or the entire genome. Probes and test kits are provided for use in tumor cytogenetics, in the detection of disease related loci, in analysis of structural abnormalities, such as translocations, and for biological dosimetry. Further, methods and prenatal test kits are provided to stain targeted chromosomal material of fetal cells, including fetal cells obtained from maternal blood. Still further, the invention provides for automated means to detect and analyse chromosomal abnormalities.

  16. Innovative Methods for Soil DNA Purification Tested in Soils with Widely Differing Characteristics▿ †

    OpenAIRE

    Sagova-Mareckova, Marketa; Cermak, Ladislav; Novotna, Jitka; Plhackova, Kamila; Forstova, Jana; Kopecky, Jan

    2008-01-01

    Seven methods of soil DNA extraction and purification were tested in a set of 14 soils differing in bedrock, texture, pH, salinity, moisture, organic matter content, and vegetation cover. The methods introduced in this study included pretreatment of soil with CaCO3 or purification of extracted DNA by CaCl2. The performance of innovated methods was compared to that of the commercial kit Mo Bio PowerSoil and the phenol-chloroform-based method of D. N. Miller, J. E. Bryant, E. L. Madsen, and W. ...

  17. Innovation and Firms' Productivity Growth in Slovenia: Sensitivity of Results to Sectoral Heterogeneity and to Estimation Method

    OpenAIRE

    Jaklič, Andreja; Damijan, Jože P.; Kostevc, Črt; Rojec, Matija

    2008-01-01

    The paper examines implications of endogenous growth theory on the relationship between firm productivity, innovation as well as productivity growth by combining infirmation on firm-level innovation (CIS) with accounting data for a large sample of Slovenian firms in the period 1996-2002. We employ several different estimation methods in order to control for the endogeneity of innovation (Crä¿»on-Duguet- Mairesse - CDM - approach) and idiosyncratic firm characteristics (matching and average tr...

  18. Dielectric relaxation in biological systems physical principles, methods, and applications

    CERN Document Server

    Feldman, Yuri

    2015-01-01

    This title covers the theoretical basis and practical aspects of the study of dielectric properties of biological systems, such as water, electrolyte and polyelectrolytes, solutions of biological macromolecules, cells suspensions and cellular systems.

  19. Studies on the Properties of ZnO Crystal Plane Grown by the Innovated Hydrothermal Method

    Institute of Scientific and Technical Information of China (English)

    WANG Yong-Hao; CHEN Da-Gui; LI Wei; HUANG Jia-Kui; WANG Guo-Hong; LIN Zhang; HUANG Feng

    2008-01-01

    ZnO single crystals were grown by the innovated hydrothermal method. The crystal surfaces were polished, and then studied by atom force microscope (AFM) and wet-chemical etching (WCE). It was found that the Zn polar plane was smoother than O polar plane under the same polishing conditions. The etch pit density of Zn polar plane is 4.3×103 cm-2,which is consistent with the previous report, while the density of etch pit of O polar plane is more than 103 cm-2. After annealing treatment, the density of etch pit of Zn plane reduces to 5.8×102 cm-2 and is superior to the current report. This investigation reveals that the high quality ZnO single crystals with fine Zn polar plane can be obtained by the innovated hydrothermal method.

  20. An Innovative Teaching Method To Promote Active Learning: Team-Based Learning

    Science.gov (United States)

    Balasubramanian, R.

    2007-12-01

    Traditional teaching practice based on the textbook-whiteboard- lecture-homework-test paradigm is not very effective in helping students with diverse academic backgrounds achieve higher-order critical thinking skills such as analysis, synthesis, and evaluation. Consequently, there is a critical need for developing a new pedagogical approach to create a collaborative and interactive learning environment in which students with complementary academic backgrounds and learning skills can work together to enhance their learning outcomes. In this presentation, I will discuss an innovative teaching method ('Team-Based Learning (TBL)") which I recently developed at National University of Singapore to promote active learning among students in the environmental engineering program with learning abilities. I implemented this new educational activity in a graduate course. Student feedback indicates that this pedagogical approach is appealing to most students, and promotes active & interactive learning in class. Data will be presented to show that the innovative teaching method has contributed to improved student learning and achievement.

  1. The method validation step of biological dosimetry accreditation process

    International Nuclear Information System (INIS)

    One of the missions of the Laboratory of Biological Dosimetry (L.D.B.) of the Institute for Radiation and Nuclear Safety (I.R.S.N.) is to assess the radiological dose after an accidental overexposure suspicion to ionising radiation, by using radio-induced changes of some biological parameters. The 'gold standard' is the yield of dicentrics observed in patients lymphocytes, and this yield is converted in dose using dose effect relationships. This method is complementary to clinical and physical dosimetry, for medical team in charge of the patients. To obtain a formal recognition of its operational activity, the laboratory decided three years ago, to require an accreditation, by following the recommendations of both 17025 General Requirements for the Competence of Testing and Calibration Laboratories and 19238 Performance criteria for service laboratories performing biological dosimetry by cyto-genetics. Diagnostics, risks analysis were realized to control the whole analysis process leading to documents writing. Purchases, personnel department, vocational training were also included in the quality system. Audits were very helpful to improve the quality system. One specificity of this technique is that it is not normalized therefore apart from quality management aspects, several technical points needed some validations. An inventory of potentially influent factors was carried out. To estimate their real effect on the yield of dicentrics, a Placket-Burman experimental design was conducted. The effect of seven parameters was tested: the BUdr (bromodeoxyuridine), PHA (phytohemagglutinin) and colcemid concentration, the culture duration, the incubator temperature, the blood volume and the medium volume. The chosen values were calculated according to the uncertainties on the way they were measured i.e. pipettes, thermometers, test tubes. None of the factors has a significant impact on the yield of dicentrics. Therefore the uncertainty linked to their use was considered as

  2. Biologic data, models, and dosimetric methods for internal emitters

    International Nuclear Information System (INIS)

    The absorbed radiation dose from internal emitters has been and will remain a pivotal factor in assessing risk and therapeutic utility in selecting radiopharmaceuticals for diagnosis and treatment. Although direct measurements of absorbed dose and dose distributions in vivo have been and will continue to be made in limited situations, the measurement of the biodistribution and clearance of radiopharmaceuticals in human subjects and the use of this data is likely to remain the primary means to approach the calculation and estimation of absorbed dose from internal emitters over the next decade. Since several approximations are used in these schema to calculate dose, attention must be given to inspecting and improving the application of this dosimetric method as better techniques are developed to assay body activity and as more experience is gained in applying these schema to calculating absorbed dose. Discussion of the need for considering small scale dosimetry to calculate absorbed dose at the cellular level will be presented in this paper. Other topics include dose estimates for internal emitters, biologic data mathematical models and dosimetric methods employed. 44 refs

  3. 09091 Executive Summary -- Formal Methods in Molecular Biology

    OpenAIRE

    Breitling, Rainer; Gilbert, David Roger; Heiner, Monika; Priami, Corrado

    2009-01-01

    Formal logical models play an increasing role in the newly emerging field of Systems Biology. Compared to the classical, well-established approach of modeling biological processes using continuous and stochastic differential equations, formal logical models offer a number of important advantages. Many different formal modeling paradigms have been applied to molecular biology, each with its own community, formalisms and tools. In this seminar we brought together modelers from variou...

  4. Global optimization in systems biology: stochastic methods and their applications

    OpenAIRE

    Balsa-Canto, Eva; Banga, Julio R.; Egea, José A.; Villaverde, A. F.; Hijas-Liste, G. M.

    2012-01-01

    Mathematical optimization is at the core of many problems in systems biology: (1) as the underlying hypothesis for model development, (2) in model identification, or (3) in the computation of optimal stimulation procedures to synthetically achieve a desired biological behavior. These problems are usually formulated as nonlinear programing problems (NLPs) with dynamic and algebraic constraints. However the nonlinear and highly constrained nature of systems biology models, together with the usu...

  5. Biological activity of terpene compounds produced by biotechnological methods.

    Science.gov (United States)

    Paduch, Roman; Trytek, Mariusz; Król, Sylwia K; Kud, Joanna; Frant, Maciej; Kandefer-Szerszeń, Martyna; Fiedurek, Jan

    2016-06-01

    Context Biotransformation systems are profitable tools for structural modification of bioactive natural compounds into valuable biologically active terpenoids. Objective This study determines the biological effect of (R)-(+)-limonene and (-)-α-pinene, and their oxygenated derivatives, (a) perillyl alcohol and (S)-(+)- and (R)-(-)-carvone enantiomers and (b) linalool, trans-verbenol and verbenone, respectively, on human colon tumour cells and normal colonic epithelium. Materials and methods Biotransformation procedures and in vitro cell culture tests were used in this work. Cells were incubated for 24 h with terpenes at concentrations of 5-500 μg/mL for NR, MTT, DPPH, and NO assays. IL-6 was determined by ELISA with/without 2 h pre-activation with 10 μg/mL LPS. Results trans-Verbenol and perillyl alcohol, obtained via biotransformation, produced in vitro effect against tumour cells at lower concentrations (IC50 value = 77.8 and 98.8 μg/mL, respectively) than their monoterpene precursors, (R)-(+)-limonene (IC50 value = 171.4 μg/mL) and (-)-α-pinene (IC50 value = 206.3 μg/mL). They also showed lower cytotoxicity against normal cells (IC50 > 500 and > 200 μg/mL, respectively). (S)-(+)-Carvone was 59.4% and 27.1% more toxic to tumour and normal cells, respectively, than the (R)-(-)-enantiomer. (R)-(+)-limonene derivatives decreased IL-6 production from normal cells in media with or without LPS (30.2% and 13.9%, respectively), while (-)-α-pinene derivatives induced IL-6 (verbenone had the strongest effect, 60.2% and 29.1% above control, respectively). None of the terpenes had antioxidative activity below 500 μg/mL. Discussion and conclusions Bioactivity against tumour cells decreased in the following order: alcohols > ketones > hydrocarbons. (R)-(+)-limonene, (-)-α-pinene, and their derivatives expressed diverse activity towards normal and tumour cells with noticeable enantiomeric differences. PMID:26808720

  6. Innovative Methods of Male Circumcision for HIV Prevention-Getting the Right Evidence.

    Science.gov (United States)

    Samuelson, Julia; Hargreave, Timothy; Ridzon, Renee; Farley, Tim

    2016-06-01

    World Health Organization recommends that countries with hyperendemic and generalized HIV epidemics implement voluntary medical male circumcision programs for HIV prevention. Innovative methods of male circumcision including devices have the potential to simplify the procedure, reduce time and cost, increase client acceptability, enhance safety, and expand the numbers of providers who may perform circumcision. We describe work led by World Health Organization and supported by global partners to define a pathway for the evaluation of efficacy and safety of male circumcision devices, to set priority criteria, and to establish a process to guide the use of devices in publicly funded voluntary medical male circumcision programs for HIV prevention. A device classification scheme, an expert Technical Advisory Group on Innovations in Male Circumcision, and a formal prequalification program have also guided considerations on safe use of devices. A rigorous approach was deemed appropriate given the intervention is for use among healthy men for public health purposes. The pathway and processes led to coordinated research, better standardization in research outcomes, and guidance that informed the research, introduction and implementation phases. The lessons learnt from this case study can inform evaluation and use of future public health innovations. PMID:27331591

  7. Methodical approaches to the choice of strategies of advancement of innovations on the market

    Directory of Open Access Journals (Sweden)

    O.M. Derikolenko

    2010-06-01

    Full Text Available It is offered to formulate the complex strategy which considers: risk kinds, types of innovations, requirements of the concrete innovation, the degree of novelty of themarket/goods/technology and activity scales on the basis of allocation of strategic advantages of the enterprise-innovator, risks of its innovative projects and market "signals".

  8. Usefulness and limits of biological dosimetry based on cytogenetic methods

    International Nuclear Information System (INIS)

    Damage from occupational or accidental exposure to ionising radiation is often assessed by monitoring chromosome aberrations in peripheral blood lymphocytes, and these procedures have, in several cases, assisted physicians in the management of irradiated persons. Thereby, circulating lymphocytes, which are in the G0 stage of the cell cycle are stimulated with a mitogenic agent, usually phytohaemagglutinin, to replicate in vitro their DNA and enter cell division, and are then observed for abnormalities. Comparison with dose response relationships obtained in vitro allows an estimate of exposure based on scoring: - Unstable aberrations by the conventional, well-established analysis of metaphases for chromosome abnormalities or for micronuclei; - So-called stable aberrations by the classical G-banding (Giemsa-Stain-banding) technique or by the more recently developed fluorescent in situ hybridisation (FISH) method using fluorescent-labelled probes for centromeres and chromosomes. Three factors need to be considered in applying such biological dosimetry: (1) Radiation doses in the body are often inhomogeneous. A comparison of the distribution of the observed aberrations among with that expected from a normal poisson distribution can allow conclusions to be made with regard to the inhomogeneity of exposure by means of the so-called contaminated poisson distribution method; however, its application requires a sufficiently large number of aberrations, i.e. an exposure to a rather large dose at a high dose rate. (2) Exposure can occur at a low dose rate (e.g. from spread or lost radioactive sources) rendering a comparison with in vitro exposure hazardous. Dose-effect relationships of most aberrations that were scored, such as translocations, follow a square law. Repair intervening during exposure reduces the quadratic component with decreasing dose rate as exposure is spread over a longer period of time. No valid solution for this problem has yet been developed, although

  9. Usefulness and limits of biological dosimetry based on cytogenetic methods.

    Science.gov (United States)

    Léonard, A; Rueff, J; Gerber, G B; Léonard, E D

    2005-01-01

    Damage from occupational or accidental exposure to ionising radiation is often assessed by monitoring chromosome aberrations in peripheral blood lymphocytes, and these procedures have, in several cases, assisted physicians in the management of irradiated persons. Thereby, circulating lymphocytes, which are in the G0 stage of the cell cycle are stimulated with a mitogenic agent, usually phytohaemagglutinin, to replicate in vitro their DNA and enter cell division, and are then observed for abnormalities. Comparison with dose-response relationships obtained in vitro allows an estimate of exposure based on scoring: Unstable aberrations by the conventional, well-established analysis of metaphases for chromosome abnormalities or for micronuclei; So-called stable aberrations by the classical G-banding (Giemsa-Stain-banding) technique or by the more recently developed fluorescent in situ hybridisation (FISH) method using fluorescent-labelled probes for centromeres and chromosomes. Three factors need to be considered in applying such biological dosimetry: (1) Radiation doses in the body are often inhomogeneous. A comparison of the distribution of the observed aberrations among cells with that expected from a normal poisson distribution can allow conclusions to be made with regard to the inhomogeneity of exposure by means of the so-called contaminated poisson distribution method; however, its application requires a sufficiently large number of aberrations, i.e. an exposure to a rather large dose at a high dose rate. (2) Exposure can occur at a low dose rate (e.g. from spread or lost radioactive sources) rendering a comparison with in vitro exposure hazardous. Dose-effect relationships of most aberrations that were scored, such as translocations, follow a square law. Repair intervening during exposure reduces the quadratic component with decreasing dose rate as exposure is spread over a longer period of time. No valid solution for this problem has yet been developed, although

  10. Innovative value-added chain. The short innovative way to the market of biological natural gas. How supply and demand increasingly get in touch; Innovative Wertschoepfungskette. Der kurze innovative Weg zum Bioerdgas-Markt. Wie Angebot und Nachfrage besser zusammenfinden

    Energy Technology Data Exchange (ETDEWEB)

    Schuermann, Vera; Kern, Helmut [Arcanum Energy Management GmbH / Arcanum Energy Systems GmbH und Co. KG, Unna (Germany)

    2011-07-01

    With the business concept ''Biogas Pool fuer Stadtwerke'' the business company Arcanum Energy Systems GmbH and Co. KG contributes an innovative and unique input to the market development of the biogas feed in. The ''Biogas Pool fuer Stadtwerke'' enables the municipal energy suppliers a long term secured acquisition of biogas, without self-investing into the raw biogas production. The investment for the biogas production is done by the farmers, who develop on this way a permanent and secure business field as ''energy hosts''. Every Biogas plant will be supplemented with a concentration plant by the Biogas Pool. Communal public services participate proportionately according to their ordered quantities. Pool solutions are already realized successfully on three different places of location in Northern Germany. Furthermore, BiomethaneCenter (BioerdgasZentrale) by Arcanum Energy accomplishes supply and demand on bio methane market without involving intercalated chandlers e.g. conglomerates. Producers of biogas and gas consumers, e.g. communal public services are directly contracting by a nationwide network. The network determines nationwide availabilities and quantity demanded. (orig.)

  11. Broadcast search via open innovation intermediaries : multi-method research on organizational success factors

    OpenAIRE

    Zynga, Andreas Michael

    2015-01-01

    Open Innovation is the practice of solving technical needs by accessing networks of solution providers external to the innovating organization as part of the innovation process. Many organizations use “Open Innovation Intermediaries” to gain access to such external networks. Some “Innovation Seekers” are more successful than others in working with Intermediaries to use the knowledge and solutions found through a process of broadcasting a technical need to a network of solution providers who r...

  12. Thiosemicarbazones: preparation methods, synthetic applications and biological importance

    International Nuclear Information System (INIS)

    Thiosemicarbazones are a class of compounds known by their chemical and biological properties, such as antitumor, antibacterial, antiviral and antiprotozoal activity. Their ability to form chelates with metals has great importance in their biological activities. Their synthesis is very simple, versatile and clean, usually giving high yields. They are largely employed as intermediates, in the synthesis of others compounds. This article is a survey of some of these characteristics showing their great importance to organic and medicinal chemistry. (author)

  13. Computational Systems Biology in Cancer: Modeling Methods and Applications

    OpenAIRE

    Wayne Materi; Wishart, David S.

    2007-01-01

    In recent years it has become clear that carcinogenesis is a complex process, both at the molecular and cellular levels. Understanding the origins, growth and spread of cancer, therefore requires an integrated or system-wide approach. Computational systems biology is an emerging sub-discipline in systems biology that utilizes the wealth of data from genomic, proteomic and metabolomic studies to build computer simulations of intra and intercellular processes. Several useful descriptive and pre...

  14. Design science research methods and patterns innovating information and communication technology

    CERN Document Server

    Vaishnavi, Vijay K

    2015-01-01

    Presenting innovative research methods, this second edition of a bestseller describes a simple and practical methodology for conducting cutting-edge design science research (DSR). It provides comprehensive guidance on how to conduct such research and supplies in-depth treatment of design science theory and the different types of theory that can be generated in design science research.Making novel use of the concept of patterns, it presents 84 research patterns for conducting effective DSR. It emphasizes design science theory throughout and is filled with practical examples of using patterns to

  15. Stories of staying and leaving: A mixed methods analysis of biology undergraduate choice, persistence, and departure

    Science.gov (United States)

    Lang, Sarah Adrienne

    Using a sequential, explanatory mixed methods design, this dissertation study compared students who persist in the biology major (persisters) with students who leave the biology major (switchers) in terms of how their pre-college experiences, college biology experiences, and biology performance figured into their choice of biology and their persistence in or departure from the biology major. This study combined (1) quantitative comparisons of biology persisters and switchers via a questionnaire developed for the study and survival analysis of a larger population of biology freshmen with (2) qualitative comparison of biology switchers and persisters via semi-structured life story interviews and homogenous focus groups. 319 students (207 persisters and 112 switchers) participated in the questionnaire and 36 students (20 persisters and 16 switchers) participated in life story and focus group interviews. All participants were undergraduates who entered The University of Texas at Austin as biology freshmen in the fall semesters of 2000 through 2004. Findings of this study suggest: (1) Regardless of eventual major, biology students enter college with generally the same suite of experiences, sources of personal encouragement, and reasons for choosing the biology major; (2) Despite the fact that they have also had poor experiences in the major, biology persisters do not actively decide to stay in the biology major; they simply do not leave; (3) Based upon survival analysis, biology students are most at-risk of leaving the biology major during the first two years of college and if they are African-American or Latino, women, or seeking a Bachelor of Arts degree (rather than a Bachelor of Science); (4) Biology switchers do not leave biology due to preference for other disciplines; they leave due to difficulties or dissatisfaction with aspects of the biology major, including their courses, faculty, and peers; (5) Biology performance has a differential effect on persistence in

  16. Comparison of Unsupervised Vegetation Classification Methods from Vhr Images after Shadows Removal by Innovative Algorithms

    Science.gov (United States)

    Movia, A.; Beinat, A.; Crosilla, F.

    2015-04-01

    The recognition of vegetation by the analysis of very high resolution (VHR) aerial images provides meaningful information about environmental features; nevertheless, VHR images frequently contain shadows that generate significant problems for the classification of the image components and for the extraction of the needed information. The aim of this research is to classify, from VHR aerial images, vegetation involved in the balance process of the environmental biochemical cycle, and to discriminate it with respect to urban and agricultural features. Three classification algorithms have been experimented in order to better recognize vegetation, and compared to NDVI index; unfortunately all these methods are conditioned by the presence of shadows on the images. Literature presents several algorithms to detect and remove shadows in the scene: most of them are based on the RGB to HSI transformations. In this work some of them have been implemented and compared with one based on RGB bands. Successively, in order to remove shadows and restore brightness on the images, some innovative algorithms, based on Procrustes theory, have been implemented and applied. Among these, we evaluate the capability of the so called "not-centered oblique Procrustes" and "anisotropic Procrustes" methods to efficiently restore brightness with respect to a linear correlation correction based on the Cholesky decomposition. Some experimental results obtained by different classification methods after shadows removal carried out with the innovative algorithms are presented and discussed.

  17. Research with School Students: Four Innovative Methods Used to Explore Effective Teaching

    Directory of Open Access Journals (Sweden)

    Jessica Faye Heal

    2015-03-01

    Full Text Available This article outlines four research methods we’ve employed to enhance how students from low-income backgrounds engage in research exploring effective teaching. It firstly outlines the need to be innovative, drawing Article 12 of the United Nations Convention on the Rights of the Child, and then moves on to explain two methods that scaffold a semi-structured interview, one child-led classroom tour and finally a creative ‘draw and tell’ approach. It argues that these methods are successful because they disrupt the researcher-participant power imbalance using the following techniques: Familiarity to the student, empowering the student to be an expert, and giving the student choice.

  18. The effect of teaching methods on cognitive achievement, retention, and attitude among in biology studying

    OpenAIRE

    Snezana Stavrova Veselinovskaa

    2011-01-01

    The purpose of this paper is to determine the effects of usage of sequential teaching method on the academic achievement and retention level of students. Three student groups of biology students in University “Goce Delcev”, Faculty of Natural and Technical Sciences, Institute of Biology, - Stip, R. Macedonia were offered a topic on general characteristics of Proteins: Their Biological Functions and Primary Structure with different sequences of 3 teaching methods. The teaching methods were Lab...

  19. Levels of Biological Diversity: a Spatial Approach to Assessment Methods

    Directory of Open Access Journals (Sweden)

    ALEXANDRU-IONUŢ PETRIŞOR

    2008-01-01

    Full Text Available Biological diversity, interpreted as a variety of natural and man-dominated biological and ecological systems, plays an important role in assuring their stability and can be interpreted at different spatial scales, based on the hierarchical level of the system (biocoenose/ ecosystem, biome/complex of ecosystem, biosphere/ecosphere. Literature distinguishes six levels of biodiversity, namely alpha, beta, gamma, delta, epsilon, and omega. The current paper lists methodologies appropriate for assessing diversity at each of these levels, with a particular focus on regional diversity (gamma, delta, and epsilon diversities, i.e. CORINE land cover classification and the biogeographical regions of the European Union.

  20. A Comparative Study of Methods To Validate Formaldehyde Decontamination of Biological Safety Cabinets

    OpenAIRE

    Munro, Kerry; Lanser, Janice; Flower, Robert

    1999-01-01

    Methods of validation of formaldehyde decontamination of biological safety cabinets were compared. Decontamination of metal strips inoculated with Mycobacterium bovis, poliovirus, or Bacillus spp. spores was compared with the results obtained with three biological indicators. Conditions for successful decontamination, particularly relative humidity, were defined. The Attest 1291 biological indicator was the only biological indicator which was an aid in the detection of gross decontamination f...

  1. Stable isotope methods in biological and ecological studies of arthropods

    NARCIS (Netherlands)

    Hood-Nowotny, R.C.; Knols, B.G.J.

    2007-01-01

    This is an eclectic review and analysis of contemporary and promising stable isotope methodologies to study the biology and ecology of arthropods. It is augmented with literature from other disciplines, indicative of the potential for knowledge transfer. It is demonstrated that stable isotopes can b

  2. Quantum mechanical simulation methods for studying biological systems

    International Nuclear Information System (INIS)

    Most known biological mechanisms can be explained using fundamental laws of physics and chemistry and a full understanding of biological processes requires a multidisciplinary approach in which all the tools of biology, chemistry and physics are employed. An area of research becoming increasingly important is the theoretical study of biological macromolecules where numerical experimentation plays a double role of establishing a link between theoretical models and predictions and allowing a quantitative comparison between experiments and models. This workshop brought researchers working on different aspects of the development and application of quantum mechanical simulation together, assessed the state-of-the-art in the field and highlighted directions for future research. Fourteen lectures (theoretical courses and specialized seminars) deal with following themes: 1) quantum mechanical calculations of large systems, 2) ab initio molecular dynamics where the calculation of the wavefunction and hence the energy and forces on the atoms for a system at a single nuclear configuration are combined with classical molecular dynamics algorithms in order to perform simulations which use a quantum mechanical potential energy surface, 3) quantum dynamical simulations, electron and proton transfer processes in proteins and in solutions and finally, 4) free seminars that helped to enlarge the scope of the workshop. (N.T.)

  3. Using Collision Cones to Asses Biological Deconiction Methods

    Science.gov (United States)

    Brace, Natalie

    For autonomous vehicles to navigate the world as efficiently and effectively as biological species, improvements are needed in terms of control strategies and estimation algorithms. Reactive collision avoidance is one specific area where biological systems outperform engineered algorithms. To better understand the discrepancy between engineered and biological systems, a collision avoidance algorithm was applied to frames of trajectory data from three biological species (Myotis velifer, Hirundo rustica, and Danio aequipinnatus). The algorithm uses information that can be sensed through visual cues (relative position and velocity) to define collision cones which are used to determine if agents are on a collision course and if so, to find a safe velocity that requires minimal deviation from the original velocity for each individual agent. Two- and three-dimensional versions of the algorithm with constant speed and maximum speed velocity requirements were considered. The obstacles provided to the algorithm were determined by the sensing range in terms of either metric or topological distance. The calculated velocities showed good correlation with observed velocities over the range of sensing parameters, indicating that the algorithm is a good basis for comparison and could potentially be improved with further study.

  4. Thin film composition with biological substance and method of making

    International Nuclear Information System (INIS)

    The invention provides a thin-film composition comprising an underlying substrate of a first material including a plurality of attachment sites; a plurality of functional groups chemically attached to the attachment sites of the underlying substrate; and a thin film of a second material deposited onto the attachment sites of the underlying substrate, and a biologically active substance deposited with the thin-film. Preferably the functional groups are attached to a self assembling monolayer attached to the underlying substrate. Preferred functional groups attached to the underlying substrate are chosen from the group consisting of carboxylates, sulfonates, phosphates, optionally substituted, linear or cyclo, alkyl, alkene, alkyne, aryl, alkylaryl, amine, hydroxyl, thiol, silyl, phosphoryl, cyano, metallocenyl, carbonyl, and polyphosphate. Preferred materials for the underlying substrate are selected from the group consisting of a metal, a metal alloy, a plastic, a polymer, a proteic film, a membrane, a glass or a ceramic. The second material is selected from the group consisting of inorganic crystalline structures, inorganic amorphous structures, organic crystalline structures, and organic amorphous structures. Preferred second materials are phosphates, especially calcium phosphates and most particularly calcium apatite. The biologically active molecule is a protein, peptide, DNA segment, RNA segment, nucleotide, polynucleotide, nucleoside, antibiotic, antimicrobial, radioisotope, chelated radioisotope, chelated metal, metal salt, anti-inflammatory, steroid, nonsteroid anti-inflammatory, analgesic, antihistamine, receptor binding agent, or chemotherapeutic agent, or other biologically active material. Preferably the biologically active molecule is an osteogenic factor consisting of the compositions listed above

  5. Handbook of design research methods in education innovations in science, technology, engineering, and mathematics learning and teaching

    CERN Document Server

    Lesh, Richard A; Baek, John Y

    2008-01-01

    This Handbook presents the latest thinking and current examples of design research in education. Design-based research involves introducing innovations into real-world practices (as opposed to constrained laboratory contexts) and examining the impact of those designs on the learning process. Designed prototype applications (e.g., instructional methods, software or materials) and the research findings are then cycled back into the next iteration of the design innovation in order to build evidence of the particular theories being researched, and to positively impact practice and the diffusion of the innovation. The Handbook of Design Research Methods in Education-- the defining book for the field -- fills a need in how to conduct design research by those doing so right now. The chapters represent a broad array of interpretations and examples of how today's design researchers conceptualize this emergent methodology across areas as diverse as educational leadership, diffusion of innovations, complexity theory, an...

  6. Innovation accounting methods to assure validated learning : the case of Finnish startups

    OpenAIRE

    Soto, Esteban

    2015-01-01

    This research takes a look at the different ways to measure progress while in a startup. Based on the different theories explained during the literature review, it is clear that a startup needs to measure its progress in a special manner. The theoretical background starts from briefly defining a startup, innovation and the sources of innovation. Then moves to explain the Lean Startup method’s ideas, validated learning, measuring innovation and innovation accounting (IA) for startups. ...

  7. Determination of Innovation Capability of Organizations: Qualitative Meta Synthesis and Delphi Method

    DEFF Research Database (Denmark)

    Momeni, Mostafa; Nielsen, Susanne Balslev; Kafash, Mahdi Haghighi

    2015-01-01

    in this rapidly changing world. This research focuses on recognition of the aspects of innovation capability and proposes a conceptual model based on a qualitative Meta-Analysis of academic literature on organisations innovation capability. This is proposed for the development of the concept of innovation...

  8. User Innovation Management

    DEFF Research Database (Denmark)

    Kanstrup, Anne Marie; Bertelsen, Pernille

    User Innovation Management (UIM) is a method for fo-opereation with users in innovation projects. The UIM method emphasizes the practice of a participatorty attitude.......User Innovation Management (UIM) is a method for fo-opereation with users in innovation projects. The UIM method emphasizes the practice of a participatorty attitude....

  9. The method innovation in nuclear equipment quality witness tracing and management

    International Nuclear Information System (INIS)

    The total construction cost of a nuclear power plant, equipment procurement cost accounts for about 47%-53%. Whether the quality of equipment can meet the technical requirements plays a significant role in the operation and maintenance of a nuclear power plant. Only if we adopt effective management can the equipment quality be ensured. As the most important method of quality control, the effective attendance and track of quality witness points has a crucial effect on contract smooth implementation as well. The essay mainly illustrates the method of quality witness point tracing and management and how to incorporate serious minded ideas and all take part in ways into quality management, hoping to offer some enlightenment on the innovation of nuclear power equipment quality management. (author)

  10. Innovative Method Using Magnetic Particle Tracking to Measure Solids Circulation in a Spouted Bed

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, Ms. Emily [Waynesburg University; Halow, John [Waynesburg University; Daw, C Stuart [ORNL

    2010-01-01

    We describe an innovative method for measuring particle motion inside spouted fluidized beds. The method uses a magnetic tracer particle, which follows the bulk particle flow and is continuously tracked by multiple magnetic field detectors located outside the bed. We analyze signals from the detectors to determine the tracer position at each instant in time. From statistical analysis of the tracer trajectory, characteristic measures of the bulk particle flow, such as the average recirculation frequency, can be determined as a function of operating conditions. For experiments with a range of particle sizes and densities in a 3.9-cm-diameter spouted bed, we find that average solids recirculation rates correlate with excess velocity (superficial minus minimum spouting velocity), particle density, and bed depth.

  11. Innovative method using magnetic particle tracking to measure solids circulation in a spouted fluidized bed

    Energy Technology Data Exchange (ETDEWEB)

    Patterson, Ms. Emily [Waynesburg University; Halow, John [Waynesburg University; Daw, C Stuart [ORNL

    2009-01-01

    We describe an innovative method for measuring particle motion inside spouted fluidized beds. The method uses a magnetic tracer particle, which follows the bulk particle flow and is continuously tracked by multiple magnetic field detectors located outside the bed. We analyze signals from the detectors to determine the tracer position at each instant in time. From statistical analysis of the tracer trajectory, characteristic measures of the bulk particle flow, such as the average recirculation frequency, can be determined as a function of operating conditions. For experiments with a range of particle sizes and densities in a 3.9-cm-diameter spouted bed, we find that average solids recirculation rates correlate with excess velocity (superficial minus minimum spouting velocity), particle density, and bed depth.

  12. Recent advances in bio-logging science: Technologies and methods for understanding animal behaviour and physiology and their environments

    Science.gov (United States)

    Evans, K.; Lea, M.-A.; Patterson, T. A.

    2013-04-01

    The deployment of an ever-evolving array of animal-borne telemetry and data logging devices is rapidly increasing our understanding of the movement, behaviour and physiology of a variety species and the complex, and often highly dynamic, environments they use and respond to. The rapid rate at which new technologies, improvements to current technologies and new analytical techniques are being developed has meant that movements, behaviour and physiological processes are being quantified at finer spatial and temporal scales than ever before. The Fourth International Symposium on Bio-logging Science, held on 14-18 March in Hobart, Australia, brought together scientists across multiple disciplines to discuss the latest innovations in technology, applications and analytical techniques in bio-logging science, building on research presented at three previous conferences. Here we present an update on the state of bio-logging research and provide some views on the future of this field of research. Papers were grouped into five theme areas: (i) Southern Ocean ecosystems; (ii) fishery and biodiversity management applications; (iii) from individuals to populations—inferences of population dynamics from individuals; (iv) conservation biology and (v) habitat modelling. Papers reflected wider uptake of newer technologies, with a greater proportion of studies utilising accelerometry and incorporating advances in statistical modelling of behaviour and habitats, especially via state space modelling methods. Environmental data collected by tags at increasing accuracies are now having wider application beyond the bio-logging community, providing important oceanographic data from regions difficult to sample using traditional methodologies. Partnerships between multiple organisations are also now enabling regional assessments of species movements, behaviour and physiology at population scales and will continue to be important for applying bio-logging technologies to species

  13. PARTICIPATORY INNOVATION

    OpenAIRE

    JACOB BUUR; BEN MATTHEWS

    2008-01-01

    An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant approaches, compares them in terms of goals, methods and basic philosophy, and shows how they may beneficially enrich one another. We will present an industrial innovation case that has been instrumental ...

  14. Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

    Science.gov (United States)

    Sills, Erin O; Herrera, Diego; Kirkpatrick, A Justin; Brandão, Amintas; Dickson, Rebecca; Hall, Simon; Pattanayak, Subhrendu; Shoch, David; Vedoveto, Mariana; Young, Luisa; Pfaff, Alexander

    2015-01-01

    Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM) offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual) scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012). This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and permutations on policies

  15. Estimating the Impacts of Local Policy Innovation: The Synthetic Control Method Applied to Tropical Deforestation.

    Directory of Open Access Journals (Sweden)

    Erin O Sills

    Full Text Available Quasi-experimental methods increasingly are used to evaluate the impacts of conservation interventions by generating credible estimates of counterfactual baselines. These methods generally require large samples for statistical comparisons, presenting a challenge for evaluating innovative policies implemented within a few pioneering jurisdictions. Single jurisdictions often are studied using comparative methods, which rely on analysts' selection of best case comparisons. The synthetic control method (SCM offers one systematic and transparent way to select cases for comparison, from a sizeable pool, by focusing upon similarity in outcomes before the intervention. We explain SCM, then apply it to one local initiative to limit deforestation in the Brazilian Amazon. The municipality of Paragominas launched a multi-pronged local initiative in 2008 to maintain low deforestation while restoring economic production. This was a response to having been placed, due to high deforestation, on a federal "blacklist" that increased enforcement of forest regulations and restricted access to credit and output markets. The local initiative included mapping and monitoring of rural land plus promotion of economic alternatives compatible with low deforestation. The key motivation for the program may have been to reduce the costs of blacklisting. However its stated purpose was to limit deforestation, and thus we apply SCM to estimate what deforestation would have been in a (counterfactual scenario of no local initiative. We obtain a plausible estimate, in that deforestation patterns before the intervention were similar in Paragominas and the synthetic control, which suggests that after several years, the initiative did lower deforestation (significantly below the synthetic control in 2012. This demonstrates that SCM can yield helpful land-use counterfactuals for single units, with opportunities to integrate local and expert knowledge and to test innovations and

  16. ACTIVE AND PARTICIPATORY METHODS IN BIOLOGY: PROBLEM-SOLVING

    OpenAIRE

    Adela NEMEŞ; Nicoleta IANOVICI

    2010-01-01

    We face with considerable challenge of developing students’ problem solving skills in our difficult environment. Good problem solving skills empower managers in their professional and personal lives. Problem solving skills are valued by academics and employers. The informations in Biology are often presented in abstract forms without contextualisation. Creative problem-solving process involves a few steps, which together provide a structured procedure for identifying challenges, generating id...

  17. Hybrid Dynamic Optimization Methods for Systems Biology with Efficient Sensitivities

    OpenAIRE

    Nicholas R. Lewis; John D. Hedengren; Haseltine, Eric L.

    2015-01-01

    In recent years, model optimization in the field of computational biology has become a prominent area for development of pharmaceutical drugs. The increased amount of experimental data leads to the increase in complexity of proposed models. With increased complexity comes a necessity for computational algorithms that are able to handle the large datasets that are used to fit model parameters. In this study the ability of simultaneous, hybrid simultaneous, and sequential algorithms are tested ...

  18. Biological methods of dye removal from textile effluents - A review

    OpenAIRE

    Archna; Lokesh KN; RR Sivakiran

    2012-01-01

    Textile dyes are molecules designed to impart permanent colours to textile fabrics. They pose an environmental problem due to their toxicity and decrease the aesthetic value of water bodies into which they are discharged. Current physico-chemical technologies for dye removal cannot remove all classes of dyes, and two or more technologies are usually combined to achieve satisfactory decolourisation efficiencies. Direct biological treatment using fungi or bacteria can also be employed, but nutr...

  19. Innovative method of RES integration into the regional energy development scenarios

    International Nuclear Information System (INIS)

    Scarcity or abundance of energy resources usually depends on physical and geographical conditions in the region. However, the energy flow in the region also depends on the efficient use of energy resources, the consumption rate of energy and the possibility to use local renewable and non-renewable energy resources. Production, distribution and the use of energy resources in the region are the challenges for central and local government, business and social service, customers and other stakeholders. Development of regional energy economy should be optimized according to the available energy flow in the region using a network system analysis method, which provides solutions for developing sustainable energy economy models. The network system analysis method enables to optimize the use of local and renewable resources at the regional level and reveals available local energy resources. An efficient use of available regional resources and the use of renewable energy sources (RES) should be the main goals for the development of regional energy system. RES can compete with traditional fossil fuel with the condition that all hidden aspects are revealed. The network system analysis method enables to indicate energy flows in the region as well as indicate pros and cons of using renewable energy technologies. - Highlights: • RES integration into the regional energy development scenarios is done. • Innovative process network system (PNS) analysis method is used. • PNS method is used to optimize the use of local and renewable resources. • Analysis of energy flow in region using PNS method is done

  20. An innovative, effective and cost effective survey method using a survey-check response format.

    Science.gov (United States)

    Feil, Edward G; Severson, Herbert; Taylor, Ted K; Boles, Shawn; Albert, David A; Blair, Jason

    2007-06-01

    Maximizing the response rate to surveys involves thoughtful choices about survey design, sampling and collection methods. This paper describes an innovative survey method, to provide immediate reinforcement for responding and to minimize the response cost. This method involves using a questionnaire printed as checks on security (anti-fraud) paper with questions and responses separated using a perforated tear off section. Once a participant completes the survey, the response area is detached from the questions, thus protecting the confidentiality of the subject, and the check is returned via the banking system. This report describes the survey-check methodology, the survey flow process, and the results from four research studies which have used this method. These studies include (1) a technology accessibility survey of parents with children enrolled in a low-income preschool program; (2) a parent report of their child's behavior used as screening criteria for inclusion in a computer-mediated parent education project; (3) a follow-up questionnaire as part of a longitudinal study of child behavior, covering home and classroom interventions, and service utilization, and; (4) a survey of dentists in support of efforts to recruit them to participate in a randomized control trial of tobacco cessation in dental offices. The results of using this method show great improvement in response rates over traditionally administered surveys for three of the four reported studies. Results are discussed in terms of future applications of this method, limitations, and potential cost savings. PMID:17180473

  1. Premature chromosome condensation: A novel method for biological dosimetry

    International Nuclear Information System (INIS)

    In this study, we have investigated the utility of different test systems for biological dosimetry and possible their application for therapy regime. Human peripheral blood lymphocytes were X-irradiated and mixed in different proportions with unirradiated lymphocytes. The frequencies of chromosomal aberrations were determined by the formation of dicentrics, excess of premature chromosome condensation fragments and micronuclie in cytochalasin B-blocked binucleated cells. These responses were with regard to estimate the dose received and to determine the population of unexposed cells (useful for the purpose of therapy) are discussed. 6 refs, 3 figs, 3 tabs

  2. Inaccuracies of nitric oxide measurement methods in biological media

    OpenAIRE

    Hunter, Rebecca A.; Storm, Wesley L.; Coneski, Peter N.; Schoenfisch, Mark H.

    2013-01-01

    Despite growing reports on the biological action of nitric oxide (NO) as a function of NO payload, the validity of such work is often questionable due to the manner in which NO is measured and/or the solution composition in which NO is quantified. To highlight the importance of measurement technique for a given sample type, NO produced from a small molecule NO donor (N-diazeniumdiolated l-proline, PROLI/NO) and a NO-releasing xerogel film were quantified in a number of physiological buffers a...

  3. PLEIADES-HR 1A&1B image quality commissioning: innovative geometric calibration methods and results

    Science.gov (United States)

    Greslou, Daniel; de Lussy, Françoise; Amberg, Virginie; Dechoz, Cécile; Lenoir, Florie; Delvit, Jean-Marc; Lebègue, Laurent

    2013-09-01

    PLEIADES earth observing system consists of two satellites designed to provide optical 70cm resolution images to civilian and defense users. The first Pleiades satellite 1A was launched on December 2011 while the second satellite Pleiades 1B was placed on orbit, one year after, on December 2012. The calibration operations and the assessment of the image of the two satellites have been performed by CNES Image Quality team during the called commissioning phase which took place after each launch and lasted each time less than 6 months. The geometric commissioning activities consist in assessing and improving the geometric quality of the images in order to meet very demanding requirements. This paper deals with the means used and methods applied, mainly the innovative ones, in order to manage these activities. It describes both their accuracy and their operational interest. Finally it gives the main results for geometric image quality performances of the PHR system.

  4. [Is the introduction of innovative methods in cardiovascular diagnostics and therapy to quick?].

    Science.gov (United States)

    Erbel, R

    2016-03-01

    Andreas Grüntzig can be regarded as the pioneer of modern cardiology. Based on the previous experiences of Charles Dotter in Portland, Oregon, and after many years of preparation as a young 38-year-old physician and consultant he carried out the first percutaneous transluminal coronary angioplasty (PTCA) in a 38-year-old patient in Zurich in 1977, supported by the cardiac surgeons A. Senning and M. Turina. Despite high ranking publications and early preparedness to share his experiences the development of PTCA stagnated and was met with great scepticism. The technique was new, technically difficult and aimed at aortocoronary bypass surgery, which was itself still in its infancy 10 years after the introduction in Cleveland in 1968. Even after several years only two patients per week were admitted for treatment in Zurich. In a similar way the young cardiac surgeon H.R. Andersen was a pioneer in Denmark whose ideas and own experiments with a balloon catheter-assisted aortic valve implantation were not initially taken up by the leading companies of the time and publication of the data suffered lengthy delays. It took 10 years before Prof. A. Cribier in Rouen followed up his ideas and carried out the first valve implantation again in pioneer work after many years of preparation in 2002. Again, the new method for treatment of very old and high risk patients needed many years before it was accepted. The breakthrough only became possible when this new technique began to be used in cardiac surgery after the introduction of hybrid cardiac catheter operating rooms. Despite evidence-based studies innovative methods are not subject to the same criteria throughout Europe with respect to the timely introduction of innovative and validated procedures also in consideration of reimbursement and this has become an important initiative of the European Society of Cardiology (ESC). PMID:26873914

  5. Verification test on an innovated method for the studies on inheritance of resistance to rice sheath blight

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@We have recently developed a systematic method for the study on the inheritance of resistance to sheath blight. The key of the system is an innovated method of inoculation and investigation along with the employment of the permanent population. This paper reported the procedure of the system and the result of its verification.

  6. Biologic

    CERN Document Server

    Kauffman, L H

    2002-01-01

    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  7. Evaluation of an Innovative Method for Calculating Energy Intake of Hospitalized Patients

    Directory of Open Access Journals (Sweden)

    Sheila Cox Sullivan

    2016-09-01

    Full Text Available The purpose of this study was to evaluate a multi-component method for capturing nutrient intake, which used observation, photography, and an innovative computer program. To assess reliability and accuracy, multiple responsible employees (REs independently conducted nutrient intake assessments on simulated meals; each RE’s results relating to energy intake were compared to those from the other REs and to those obtained by pre- and post-meal weighing of the food items. System efficiency was assessed by having REs perform independent assessments on the same set of simulated meals using either the new or traditional hospital method for which the REs had to document each food item served and then find the items in a computer database–steps that were automated in the new method. Interrater reliability for energy intake estimated on clinic wards was excellent (intraclass correlation coefficient = 0.975, 95% CI 0.958 to 0.992 and there was a high level of agreement between the REs’ estimates and the true values determined by food weighing; per the method of Bland and Altman the mean difference between the two types of estimates was 0.3 kcal (95% CI, −8.1 to 8.7 kcal with limits of agreement of −79.5 kcal to 80.1 kcal. Compared to the traditional method, energy intake assessments could be completed using the multi-component method in less than a third of the time. These results indicate the multi-component method is an accurate, reliable, and efficient method of obtaining energy intake assessments for hospitalized patients.

  8. Chemical Pretreatment Methods for the Production of Cellulosic Ethanol: Technologies and Innovations

    Directory of Open Access Journals (Sweden)

    Edem Cudjoe Bensah

    2013-01-01

    Full Text Available Pretreatment of lignocellulose has received considerable research globally due to its influence on the technical, economic and environmental sustainability of cellulosic ethanol production. Some of the most promising pretreatment methods require the application of chemicals such as acids, alkali, salts, oxidants, and solvents. Thus, advances in research have enabled the development and integration of chemical-based pretreatment into proprietary ethanol production technologies in several pilot and demonstration plants globally, with potential to scale-up to commercial levels. This paper reviews known and emerging chemical pretreatment methods, highlighting recent findings and process innovations developed to offset inherent challenges via a range of interventions, notably, the combination of chemical pretreatment with other methods to improve carbohydrate preservation, reduce formation of degradation products, achieve high sugar yields at mild reaction conditions, reduce solvent loads and enzyme dose, reduce waste generation, and improve recovery of biomass components in pure forms. The use of chemicals such as ionic liquids, NMMO, and sulphite are promising once challenges in solvent recovery are overcome. For developing countries, alkali-based methods are relatively easy to deploy in decentralized, low-tech systems owing to advantages such as the requirement of simple reactors and the ease of operation.

  9. An action learning network method for increased innovation capability in organizations

    OpenAIRE

    Olsson, Annika; Wadell, Carl; Odenrick, Per; Norell Bergendahl, Margareta

    2010-01-01

    Product innovation in highly complex and technological areas, such as medical technology, puts high requirements on innovation capability of an organization. Previous research and publications have highlighted organizational issues and learning matters as important and necessary for the development of innovation capability. Action learning require reflections of the ways things are carried out, changes in the current actions, implementation and improvement and thereafter another round of refl...

  10. Descriptive Analysis of the Regional Innovation System - Novel Method for Public Administration Authorities

    OpenAIRE

    Matatkova, Katerina; Stejskal, Jan

    2013-01-01

    Making innovation is currently one of the key factors of economic development, both for the private sector and the public sector. The public sector can help to support the effective form of knowledge creation and development that will lead to real innovations in the administrated region. Innovations can help meet the objectives of public policies (such as the creation of new jobs and support small and medium-sized enterprises, etc.). This paper tries to summarize the findings regarding knowle...

  11. Innovation and Evolution of Business Relations and Networks: Theory and Method

    OpenAIRE

    Wilkinson, Ian; Young, Louise

    2012-01-01

    We introduce a complex systems perspective on innovation in networks in which innovation is conceptualized as a form of creative act associated with the dynamics and evolution of business network. We show how innovation is a form of creative act that involves the creation of new ideas and their exploitation, in which new ideas come from combining and recombining existing ideas in new ways that have value. We stress the need to move away from traditional linear, comparative static variables ba...

  12. Inferring cell type innovations by phylogenetic methods-concepts, methods, and limitations.

    Science.gov (United States)

    Kin, Koryu

    2015-12-01

    Multicellular organisms are composed of distinct cell types that have specific roles in the body. Each cell type is a product of two kinds of historical processes-development and evolution. Although the concept of a cell type is difficult to define, the cell type concept based on the idea of the core regulatory network (CRN), a gene regulatory network that determines the identity of a cell type, illustrates the essential aspects of the cell type concept. The first step toward elucidating cell type evolution is to reconstruct the evolutionary relationships of cell types, or the cell type tree. The sister cell type model assumes that a new cell type evolves through divergence from a multifunctional ancestral cell type, creating tree-like evolutionary relationships between cell types. The process of generating a cell type tree can also be understood as the sequential addition of a new branching point on an ancestral cell differentiation hierarchy in evolution. A cell type tree thus represents an intertwined history of cell type evolution and development. Cell type trees can be reconstructed from high-throughput sequencing data, and the reconstruction of a cell type tree leads to the discovery of genes that are functionally important for a cell type. Although many issues including the lack of cross-species comparisons and the lack of a proper model for cell type evolution remain, the study of the origin of a new cell type using phylogenetic methods offers a promising new research avenue in developmental evolution. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 653-661, 2015. © 2015 Wiley Periodicals, Inc. PMID:26462996

  13. Methodical frameworks for evaluation of financial and investment component of functionality of innovation-oriented enterprise belonged to machinery industry

    Directory of Open Access Journals (Sweden)

    К.О. Boiarynova

    2016-03-01

    Full Text Available The aim of the article. The aim of the article is to develop the methodical frameworks for evaluation of financial and investment component of functionality of innovation-oriented enterprise belonged to machinery industry. The results of the analysis. The author has analyzed approaches to evaluation of financial and investment component of the innovation-oriented enterprise activity. The article detects the sense of financial and investment environmental system of the enterprise and its constituent environments. The author has proposed a system of indices for evaluation of financial and investment environmental system of the innovation-oriented enterprise belonged to machinery industry, showing enterprise functioning phases (functional maintenance, functional reproduction, functional expanded reproduction, functional innovative reproduction and economic return and environments’ components (internal financial and investment support environment, business environment of financial relationships; investment and partnership environment, environment of financial and economic security. The article substantiates application of ratios of liquidity, solvency, financial stability, financial security, asset turnover, profitability and payback, which are distributed and adapted for evaluation of phases of functioning of machinery industry enterprises and evaluation of phases of functioning of machinery industry enterprises. The author has suggested to do the coefficient analysis of the innovative reproduction phase with the use of the following figures: a ratio of research engineering working capital financed by equity to total assets, an innovation-oriented assets ratio (the environment of internal financial support, a quick liquidity ratio of intangible assets (the business environment of financial relationships, a ratio of capital involved for innovations (the investment and partnership environment, ratio of financial independency of innovations

  14. An Innovative Wavelet Threshold Denoising Method for Environmental Drift of Fiber Optic Gyro

    Directory of Open Access Journals (Sweden)

    Qian Zhang

    2016-01-01

    Full Text Available Fiber optic gyroscope (FOG is a core component in modern inertial technology. However, the precision and performance of FOG will be degraded by environmental drift, especially in complex temperature environment. As the modeling performance is affected by the noises in the output data of FOG, an improved wavelet threshold value based on Allan variance and Classical variance is proposed for discrete wavelet analysis to decompose the temperature drift trend item and noise items. Firstly, the relationship of Allan variance and Classical variance is introduced by analyzing the drawback of traditional wavelet threshold. Secondly, an improved threshold is put forward based on Allan variance and Classical variance which overcomes the shortcoming of traditional wavelet threshold method. Finally, the innovative threshold algorithm is experimentally evaluated on FOG. The mathematical evaluation results show that the new method can get better signal-to-noise ratio (SNR and gain the reconstruction signal of the higher correlation coefficient (CC. As an experimental validation, the nonlinear capability of error back propagation neural network (BP neural network is used to fit the drift trend item and find out the complex relationship between the FOG drift and temperature, and the final processing results indicate that the new denoising method can get better root of mean square error (MSE.

  15. A magnetic method to concentrate and trap biological targets

    KAUST Repository

    Li, Fuquan

    2012-11-01

    Magnetoresistive sensors in combination with magnetic particles have been used in biological applications due to, e.g., their small size and high sensitivity. A growing interest is to integrate magnetoresistive sensors with microchannels and electronics to fabricate devices that can perform complex analyses. A major task in such systems is to immobilize magnetic particles on top of the sensor surface, which is required to detect the particles\\' stray field. In the presented work, a bead concentrator, consisting of gold microstructures, at the bottom of a microchannel, is used to attract and move magnetic particles into a trap. The trap is made of a chamber with a gold microstructure underneath and is used to attract and immobilize a defined number of magnetic beads. In order to detect targets, two kinds of solutions were prepared; one containing only superparamagnetic particles, the other one containing beads with the protein Bovine serum albumin as the target and fluorescent markers. Due to the size difference between bare beads and beads with target, less magnetic beads were immobilized inside the volume chamber in case of magnetic beads with target as compared to bare magnetic beads. © 1965-2012 IEEE.

  16. Metabolomics methods for the synthetic biology of secondary metabolism.

    Science.gov (United States)

    Nguyen, Quoc-Thai; Merlo, Maria E; Medema, Marnix H; Jankevics, Andris; Breitling, Rainer; Takano, Eriko

    2012-07-16

    Many microbial secondary metabolites are of high biotechnological value for medicine, agriculture, and the food industry. Bacterial genome mining has revealed numerous novel secondary metabolite biosynthetic gene clusters, which encode the potential to synthesize a large diversity of compounds that have never been observed before. The stimulation or "awakening" of this cryptic microbial secondary metabolism has naturally attracted the attention of synthetic microbiologists, who exploit recent advances in DNA sequencing and synthesis to achieve unprecedented control over metabolic pathways. One of the indispensable tools in the synthetic biology toolbox is metabolomics, the global quantification of small biomolecules. This review illustrates the pivotal role of metabolomics for the synthetic microbiology of secondary metabolism, including its crucial role in novel compound discovery in microbes, the examination of side products of engineered metabolic pathways, as well as the identification of major bottlenecks for the overproduction of compounds of interest, especially in combination with metabolic modeling. We conclude by highlighting remaining challenges and recent technological advances that will drive metabolomics towards fulfilling its potential as a cornerstone technology of synthetic microbiology. PMID:22710183

  17. Recent molecular biology methods for foulbrood and nosemosis diagnosis.

    Science.gov (United States)

    Rivière, M P; Ribière, M; Chauzat, M P

    2013-12-01

    Honey-bee colony losses are an increasing problem in Western countries. There are many different causes, including infections due to various pathogens. Molecular biology techniques have been developed to reliably detect and identify honey-bee pathogens. The most sensitive, specific and reliable is the quantitative real-time polymerase chain reaction (qPCR) methodology. This review of the literature describes various studies where qPCR was used to detect, identify and quantify four major honey-bee pathogens: the bacteria Paenibacillus larvae and Melissococcus plutonius (the causative agents of American foulbrood and European foulbrood, respectively) and the microsporidia Nosema apis and N. ceranae (the causative agents of nosemosis). The application of qPCR to honey-bee pathogens is very recent, and techniques are expected to improve rapidly, leading to potential new prospects for diagnosis and control. Thus, qPCR techniques could shortly become a powerful tool for investigating pathogenic infections and increasing our understanding of colony losses. PMID:24761740

  18. The open innovation — modern methods of commercialization of research results

    OpenAIRE

    V. Ilchuk

    2012-01-01

    Deals with new approaches to commercialization of technologies that require network forms of busi- ness organization and global economic cooperation. Proved the creation of open innovation†, for ma- nagement that requires knowledge and skills in field of international innovation management and cultural aspects of business communications.

  19. Comments on "Comparison of Mann-Kendall and innovative trend method for water quality parameters of the Kizilirmak River, Turkey (Kisi and Ay, 2014)" and "An innovative method for trend analysis of monthly pan evaporations (Kisi, 2015)"

    Science.gov (United States)

    Güçlü, Yavuz Selim

    2016-07-01

    Şen (2012) proposed the innovative trend analysis methodology and gave its fundamentals in a simple way based on logical deductions. Later, this methodology has been applied by many writers to different data as mentioned by Kisi and Ay (2014) and Kisi (2015), who also implemented the same methodology. In one of illustrations in their paper (Kisi and Ay, 2014) there are incorrectly scattered data and this comment includes the correction for the illustration. Additionally, Kisi's (2015) application of innovative trend method, as explained in detail by Şen (2012, 2014, 2015), has invalid confidence limits (bands) and the invalidation is explained in the comment.

  20. Photon activation method to the investigation of bioobjects content for juridical-biological examination

    International Nuclear Information System (INIS)

    Possibilities of the use of nuclear-physical methods for definition of element composition of biological objects (hair of animals) with the target of receipt of additional evidentiary information at the decision of diagnostics and identification problems within the limits of forensic-biological examination are shown

  1. Transforming Elementary Science Teacher Education by Bridging Formal and Informal Science Education in an Innovative Science Methods Course

    Science.gov (United States)

    Riedinger, Kelly; Marbach-Ad, Gili; Randy McGinnis, J.; Hestness, Emily; Pease, Rebecca

    2011-02-01

    We investigated curricular and pedagogical innovations in an undergraduate science methods course for elementary education majors at the University of Maryland. The goals of the innovative elementary science methods course included: improving students' attitudes toward and views of science and science teaching, to model innovative science teaching methods and to encourage students to continue in teacher education. We redesigned the elementary science methods course to include aspects of informal science education. The informal science education course features included informal science educator guest speakers, a live animal demonstration and a virtual field trip. We compared data from a treatment course ( n = 72) and a comparison course ( n = 26). Data collection included: researchers' observations, instructors' reflections, and teacher candidates' feedback. Teacher candidate feedback involved interviews and results on a reliable and valid Attitudes and Beliefs about the Nature of and the Teaching of Science instrument. We used complementary methods to analyze the data collected. A key finding of the study was that while benefits were found in both types of courses, the difference in results underscores the need of identifying the primary purpose for innovation as a vital component of consideration.

  2. Specific methods for theophylline assay in biological samples

    International Nuclear Information System (INIS)

    The objective of monitoring theophylline plasma levels in in therapeutic work is well established, and the consequences of using unspecific analytical methods are obvious. For the determination of pharmacokinetic parameters, concentrations far below the therapeutic range must often be measured. Interferences acceptable in therapeutic monitoring of theophylline could cause severe inaccuracy at these drug levels. The term specificity and its meaning are discussed in general and in relation to the different steps of the analytical procedure (e.g., sampling and sample work-up). Different analytical methods for theophylline are discussed in terms of specificity. Plasma concentrations of paraxanthine (1,7-dimethylxanthine) - a metabolite of caffeine - as high as 3 μg/ml have been observed, and the compound can interfere in various theophylline assay methods. An example is given of the pharmacokinetic consequences. (author)

  3. Replica exchange with solute tempering: A method for sampling biological systems in explicit water

    OpenAIRE

    Liu, Pu; Kim, Byungchan; Friesner, Richard A.; Berne, B. J.

    2005-01-01

    An innovative replica exchange (parallel tempering) method called replica exchange with solute tempering (REST) for the efficient sampling of aqueous protein solutions is presented here. The method bypasses the poor scaling with system size of standard replica exchange and thus reduces the number of replicas (parallel processes) that must be used. This reduction is accomplished by deforming the Hamiltonian function for each replica in such a way that the acceptance probability for the exchang...

  4. Responsible innovation

    CERN Document Server

    De Woot, Philippe

    2015-01-01

    Economic development is rooted in disruption, not in equilibrium. And a powerful engine of economic development is innovation; but is this innovation always for the common good? The dark side of the extraordinary dynamism of innovation lies precisely in its destructive power. If simply left to market forces, it could lead to social chaos and great human suffering. To face the challenges of our time, we must create the proper climate and culture to develop strong entrepreneurial drive. But, more than ever, we must give this entrepreneurial drive its ethical and societal dimensions. Responsible innovation means a more voluntary orientation towards the great problems of the 21st century, e.g. depletion of the planet's resources, rising inequality, and new scientific developments potentially threatening freedom, democracy and human integrity. We need to transform our ceaseless creativity into real progress for humankind. In this respect, the rapid development of social innovation opens the door for new methods an...

  5. Participatory Innovation

    DEFF Research Database (Denmark)

    Buur, Jacob; Matthews, Ben

    2008-01-01

    An increasing number of corporations engage with users in co-innovation of products and services. But there are a number of competing perspectives on how best to integrate these understandings into existing corporate innovation development processes. This paper maps out three of the dominant...... approaches, compares them in terms of goals, methods and basic philosophy, and shows how they may beneficially enrich one another. We will present an industrial innovation case that has been instrumental to the development of what we have termed ‘Participatory Innovation’. Based on this we will list...... the challenges such an approach sets to innovation management, and discuss research directions we see as fundamental to the development of the field of user-driven innovation. Udgivelsesdato: September...

  6. Innovative teaching methods in the professional training of nurses – simulation education

    Directory of Open Access Journals (Sweden)

    Michaela Miertová

    2013-12-01

    Full Text Available Introduction: The article is aimed to highlight usage of innovative teaching methods within simulation education in the professional training of nurses abroad and to present our experience based on passing intensive study programme at School of Nursing, Midwifery and Social Work, University of Salford (United Kingdom, UK within Intensive EU Lifelong Learning Programme (LPP Erasmus EU RADAR 2013. Methods: Implementation of simulation methods such as role-play, case studies, simulation scenarios, practical workshops and clinical skills workstation within structured ABCDE approach (AIM© Assessment and Management Tool was aimed to promote the development of theoretical knowledge and skills to recognize and manage acutely deteriorated patients. Structured SBAR approach (Acute SBAR Communication Tool was used for the training of communication and information sharing among the members of multidisciplinary health care team. OSCE approach (Objective Structured Clinical Examination was used for student’s individual formative assessment. Results: Simulation education is proved to have lots of benefits in the professional training of nurses. It is held in safe, controlled and realistic conditions (in simulation laboratories reflecting real hospital and community care environment with no risk of harming real patients accompanied by debriefing, discussion and analysis of all activities students have performed within simulated scenario. Such learning environment is supportive, challenging, constructive, motivated, engaging, skilled, flexible, inspiring and respectful. Thus the simulation education is effective, interactive, interesting, efficient and modern way of nursing education. Conclusion: Critical thinking and clinical competences of nurses are crucial for early recognition and appropriate response to acute deterioration of patient’s condition. These competences are important to ensure the provision of high quality nursing care. Methods of

  7. High throughput instruments, methods, and informatics for systems biology.

    Energy Technology Data Exchange (ETDEWEB)

    Sinclair, Michael B.; Cowie, Jim R. (New Mexico State University, Las Cruces, NM); Van Benthem, Mark Hilary; Wylie, Brian Neil; Davidson, George S.; Haaland, David Michael; Timlin, Jerilyn Ann; Aragon, Anthony D. (University of New Mexico, Albuquerque, NM); Keenan, Michael Robert; Boyack, Kevin W.; Thomas, Edward Victor; Werner-Washburne, Margaret C. (University of New Mexico, Albuquerque, NM); Mosquera-Caro, Monica P. (University of New Mexico, Albuquerque, NM); Martinez, M. Juanita (University of New Mexico, Albuquerque, NM); Martin, Shawn Bryan; Willman, Cheryl L. (University of New Mexico, Albuquerque, NM)

    2003-12-01

    High throughput instruments and analysis techniques are required in order to make good use of the genomic sequences that have recently become available for many species, including humans. These instruments and methods must work with tens of thousands of genes simultaneously, and must be able to identify the small subsets of those genes that are implicated in the observed phenotypes, or, for instance, in responses to therapies. Microarrays represent one such high throughput method, which continue to find increasingly broad application. This project has improved microarray technology in several important areas. First, we developed the hyperspectral scanner, which has discovered and diagnosed numerous flaws in techniques broadly employed by microarray researchers. Second, we used a series of statistically designed experiments to identify and correct errors in our microarray data to dramatically improve the accuracy, precision, and repeatability of the microarray gene expression data. Third, our research developed new informatics techniques to identify genes with significantly different expression levels. Finally, natural language processing techniques were applied to improve our ability to make use of online literature annotating the important genes. In combination, this research has improved the reliability and precision of laboratory methods and instruments, while also enabling substantially faster analysis and discovery.

  8. Glutarimides: Biological activity, general synthetic methods and physicochemical properties

    Directory of Open Access Journals (Sweden)

    Popović-Đorđević Jelena B.

    2015-01-01

    Full Text Available Glutarimides, 2,6-dioxopiperidines are compounds that rarely occur in natural sources, but so far isolated ones exert widespread pharmacological activities, which makes them valuable as potential pharmacotherapeutics. Glutarimides act as androgen receptor antagonists, anti-inflammatory, anxiolytics, antibacterials, and tumor suppressing agents. Some synthetic glutarimide derivatives are already in use as immunosuppressive and sedative (e.g., thalidomide or anxiolytics (buspirone drugs. The wide applicability of this class of compounds, justify the interest of scientists to explore new pathways for its syntheses. General methods for synthesis of six-membered imide ring, are presented in this paper. These methods include: a reaction of dicarboxylic acids with ammonia or primary amine, b reactions of cyclization: amido-acids, diamides, dinitriles, nitrilo-acids, amido-nitriles, amido-esters, amidoacyl-chlorides or diacyl-chlorides, c adition of carbon-monoxide on a,b-unsaturated amides, d oxidation reactions, e Michael adition of active methylen compounds on methacrylamide or conjugated amides. Some of the described methods are used for closing glutarimide ring in syntheses of farmacological active compounds sesbanimide and aldose reductase inhibitors (ARI. Analyses of the geometry, as well as, the spectroscopic analyses (NMR and FT-IR of some glutarimides are presented because of their broad spectrum of pharmacological activity. To elucidate structures of glutarimides, geometrical parameters of newly synthesized tert-pentyl-1-benzyl-4-methyl-glutarimide-3-carboxylate (PBMG are analyzed and compared with the experimental data from X-ray analysis for glutarimide. Moreover, molecular electrostatic potential (MEP surface which is plotted over the optimized geometry to elucidate the reactivity of PBMG molecule is analyzed. The electronic properties of glutarimide derivatives are explained on the example of thalidomide. The Frontier Molecular Orbital

  9. Combining physical, cultural and biological methods: prospects for integrated non-chemical weed management strategies

    OpenAIRE

    Hatcher, Lecturer Paul; Melander, Senior scientist Bo

    2003-01-01

    Physical, cultural and biological methods for weed control have developed largely independently and are often concerned with weed control in different systems: physical and cultural control in annual crops and biocontrol in extensive grasslands. We discuss the strengths and limitations of four physical and cultural methods for weed control: mechanical, thermal, cutting, and intercropping, and the advantages and disadvantages of combining biological control with them. These physical and cult...

  10. Optimization and validation of spectrophotometric methods for determination of finasteride in dosage and biological forms

    OpenAIRE

    Amin, Alaa S.; Kassem, Mohammed A.

    2012-01-01

    Aim and Background: Three simple, accurate and sensitive spectrophotometric methods for the determination of finasteride in pure, dosage and biological forms, and in the presence of its oxidative degradates were developed. Materials and Methods: These methods are indirect, involve the addition of excess oxidant potassium permanganate for method A; cerric sulfate [Ce(SO4)2] for methods B; and N-bromosuccinimide (NBS) for method C of known concentration in acid medium to finasteride, and the de...

  11. PLEIADES-HR 1A&1B image quality commissioning: innovative radiometric calibration methods and results

    Science.gov (United States)

    Martin, Vincent; Blanchet, Gwendoline; Kubik, Philippe; Lacherade, Sophie; Latry, Christophe; Lebegue, Laurent; Lenoir, Florie; Porez-Nadal, Florence

    2013-09-01

    PLEIADES is an earth observing system conducted by the French National Space Agency, CNES. It consists of two satellites launched on December 2011 (PHR-1A) and December 2012 (PHR-1B), both designed to provide optical pushbroom imagery on five spectral bands to civilian and defense users, with ground sample distance up to 70 cm. During inflight image quality commissioning, radiometric activities included inter-detector normalization coefficients computation, refocusing operations, MTF assessment and estimation of signal to noise ratios. This paper presents inflight results for both satellites. It focuses on several innovative methods that were implemented, taking advantage of the satellite platform great agility. These methods are based on processing images obtained through dedicated exotic guidance. In particular, slow-motion steering enables an efficient estimation of the instrumental noise model, since during acquisition each detector has been viewing a stable ground target along different time samples. Conversely, rotated retina guidance is used to guarantee that all different elementary detectors have successively viewed the same set of landscape samples during acquisition. Non-uniformity of detector sensitivities can then be characterized, and on-board coefficients used prior to compression can be calibrated in order to prevent vertical striping effects on operational images. Defocus control and Point Spread Function estimation can be easily obtained through processing acquisitions of stars associated to various spectral characteristics, for different adjustments of the refocusing system. All these methods allow an accurate estimation of radiometric performance on the whole range of specified spectral radiances, while drastically reducing the number of required acquisitions on natural targets.

  12. Control Structure Design of an Innovative Enhanced Biological Nutrient Recovery Activated Sludge System Coupled with a Photobioreactor

    DEFF Research Database (Denmark)

    Valverde Perez, Borja; Fuentes-Martínez, José Manuel; Flores Alsina, Xavier;

    2015-01-01

    The TRENS system is a train of biological units designed for resource recovery from wastewater. It is a sequence of a modified enhanced biological phosphorus removal and recovery system (EBP2R) coupled with a photobioreactor (PBR). The bacteria-based system constructs an optimal culture media for...... needed in order to assess the controllability of the PBR and the possible impact on the upstream operation conditions....

  13. Innovative Field Methods for Characterizing the Hydraulic Properties of a Complex Fractured Rock Aquifer (Ploemeur, Brittany)

    Science.gov (United States)

    Bour, O.; Le Borgne, T.; Longuevergne, L.; Lavenant, N.; Jimenez-Martinez, J.; De Dreuzy, J. R.; Schuite, J.; Boudin, F.; Labasque, T.; Aquilina, L.

    2014-12-01

    Characterizing the hydraulic properties of heterogeneous and complex aquifers often requires field scale investigations at multiple space and time scales to better constrain hydraulic property estimates. Here, we present and discuss results from the site of Ploemeur (Brittany, France) where complementary hydrological and geophysical approaches have been combined to characterize the hydrogeological functioning of this highly fractured crystalline rock aquifer. In particular, we show how cross-borehole flowmeter tests, pumping tests and frequency domain analysis of groundwater levels allow quantifying the hydraulic properties of the aquifer at different scales. In complement, we used groundwater temperature as an excellent tracer for characterizing groundwater flow. At the site scale, measurements of ground surface deformation through long-base tiltmeters provide robust estimates of aquifer storage and allow identifying the active structures where groundwater pressure changes occur, including those acting during recharge process. Finally, a numerical model of the site that combines hydraulic data and groundwater ages confirms the geometry of this complex aquifer and the consistency of the different datasets. The Ploemeur site, which has been used for water supply at a rate of about 106 m3 per year since 1991, belongs to the French network of hydrogeological sites H+ and is currently used for monitoring groundwater changes and testing innovative field methods.

  14. Innovations and trends in meat consumption: an application of the Delphi method in Spain.

    Science.gov (United States)

    Chamorro, Antonio; Miranda, Francisco J; Rubio, Sergio; Valero, Víctor

    2012-12-01

    The meat sector in Spain is an important industry. However, traditional consumption is changing as a result of the country's economic crisis and the new structure of households. The objective of the present study was to identify trends in meat consumption in Spain extrapolated to 2016, and the main innovations that should be of interest to firms in the sector. The study was conducted in 2011 using the Delphi method with the participation of 26 experts. The results showed that, while the demand for meat will not vary significantly in amount, it will do so in composition, with chicken replacing beef as the meat of most importance in the shopping basket. In addition, significant growth is expected in certified meat, but the demand for organic meat will not take off. Neither will there be no significant changes in end purchase formats, but there will be a clear trend in consumers' purchasing decision criteria away from price, external appearance and origin towards quality certification and the attributes of the packaging. With respect to end purchase channels, the experts estimate that the current trend will be accentuated with increasing market share for large supermarkets and major distribution brands. PMID:22878051

  15. Research on Catalytic Properties of Palladium Catalyst Prepared by Biological Reduction Method

    Institute of Scientific and Technical Information of China (English)

    Zhang Feng; Fu Jiquan

    2013-01-01

    This paper relates to highly dispersed supported Pd/MWCNTs and Pd/α-Al2O3 catalysts prepared by biological reduction method. The physico-chemical properties and the difference in catalytic activity of Pd catalysts prepared by bio-logical reduction method and chemical method, respectively, were investigated using XRD, TEM and speciifc surface char-acterization methods. The catalytic properties of catalysts were studied through activity evaluation means. The test results showed that the catalysts prepared by biological method were characteristic of small Pd nanoparticle size, good dispersion and low agglomeration, while possessing a high activity and stability in styrene hydrogenation reaction in comparison with catalysts prepared via the chemical method.

  16. Nitrate biosensors and biological methods for nitrate determination.

    Science.gov (United States)

    Sohail, Manzar; Adeloju, Samuel B

    2016-06-01

    The inorganic nitrate (NO3‾) anion is present under a variety of both natural and artificial environmental conditions. Nitrate is ubiquitous within the environment, food, industrial and physiological systems and is mostly present as hydrated anion of a corresponding dissolved salt. Due to the significant environmental and toxicological effects of nitrate, its determination and monitoring in environmental and industrial waters are often necessary. A wide range of analytical techniques are available for nitrate determination in various sample matrices. This review discusses biosensors available for nitrate determination using the enzyme nitrate reductase (NaR). We conclude that nitrate determination using biosensors is an excellent non-toxic alternative to all other available analytical methods. Over the last fifteen years biosensing technology for nitrate analysis has progressed very well, however, there is a need to expedite the development of nitrate biosensors as a suitable alternative to non-enzymatic techniques through the use of different polymers, nanostructures, mediators and strategies to overcome oxygen interference. PMID:27130094

  17. Apparatus and method for biological purification of waste

    Science.gov (United States)

    Lucido, John A.; Keenan, Daniel; Premuzic, Eugene T.; Lin, Mow S.; Shelenkova, Ludmila

    1998-11-24

    An apparatus is disclosed for containing a microorganism culture in an active exponential growth and delivering a supply of microorganisms to an environment containing wastes for bio-augmenting the biodegradation of the wastes. The apparatus comprises a bioreactor and an operably connected controller. The bioreactor has a bioreactor chamber for containing a supply of microorganisms, a second chamber for containing a supply of water and inorganic nutrients, and a third chamber for containing a supply of organic nutrients. The bioreactor is operably connected to the controller in which a first pump is operably connected in fluid communication between the bioreactor chamber and the second chamber and third chamber, and a second pump is operably connected in fluid communication between the bioreactor chamber and the environment containing wastes to be biodegraded. The controller further includes a timer and regulator operably connected to the first and second pumps to effectively maintain the microorganisms in exponential growth in the bioreactor chamber and to deliver microorganisms to an environment to be treated. Also, disclosed is a method for bio-augmenting the biodegradation of wastes.

  18. Teaching methods for increasing the participations of students: Innovative dynamics games Teaching methods for increasing the participations of students: Innovative dynamics games Teaching methods for increasing the participations of students: Innovative dynamics games

    Directory of Open Access Journals (Sweden)

    Ester Oliveras

    2013-09-01

    Full Text Available Purpose: This paper analyses new dynamics as teaching methodologies in the context of   the degrees adapted to the EHEA. The aim of this study is double: to assess whether there is greater involvement in seminars with these new dynamics and to test if learning also experienced changes. Design/methodology/approach: To experiment with the introduction of innovative dynamic games in an introductory course in accounting.  These new dynamics are applied during the academic year 2010-11 in the UPF. The design, implementation and evaluation of the methodology devised have followed three stages: 1 Game Design and adequate dynamic; 2 To test the games; 2 Implementation during the course. Findings: The results show that students value positively those dynamics improving their learning and creating greater involvement. Research limitations/implications: There are some contradictory results regarding the knowledge gained by the students. Another area to be explored relates to the skills that the teacher must have in order to manage this type of dynamics. Originality/value: In an introductory level of the Financial Accounting course the most common dynamics is solving exercises. Due to the nature of matter, these are closed so they not provoke discussion among students. However, you can use activities that allow greater participation, especially through dynamics or games. This paper shows that.Purpose: This paper analyses new dynamics as teaching methodologies in the context of   the degrees adapted to the EHEA. The aim of this study is double: to assess whether there is greater involvement in seminars with these new dynamics and to test if learning also experienced changes.Design/methodology/approach: To experiment with the introduction of innovative dynamic games in an introductory course in accounting.  These new dynamics are applied during the academic year 2010-11 in the UPF. The design, implementation and evaluation of the methodology devised

  19. Approaching complexity by stochastic methods: From biological systems to turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, Rudolf [Institute for Theoretical Physics, University of Muenster, D-48149 Muenster (Germany); Peinke, Joachim [Institute of Physics, Carl von Ossietzky University, D-26111 Oldenburg (Germany); Sahimi, Muhammad [Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089-1211 (United States); Reza Rahimi Tabar, M., E-mail: mohammed.r.rahimi.tabar@uni-oldenburg.de [Department of Physics, Sharif University of Technology, Tehran 11155-9161 (Iran, Islamic Republic of); Institute of Physics, Carl von Ossietzky University, D-26111 Oldenburg (Germany); Fachbereich Physik, Universitaet Osnabrueck, Barbarastrasse 7, 49076 Osnabrueck (Germany)

    2011-09-15

    This review addresses a central question in the field of complex systems: given a fluctuating (in time or space), sequentially measured set of experimental data, how should one analyze the data, assess their underlying trends, and discover the characteristics of the fluctuations that generate the experimental traces? In recent years, significant progress has been made in addressing this question for a class of stochastic processes that can be modeled by Langevin equations, including additive as well as multiplicative fluctuations or noise. Important results have emerged from the analysis of temporal data for such diverse fields as neuroscience, cardiology, finance, economy, surface science, turbulence, seismic time series and epileptic brain dynamics, to name but a few. Furthermore, it has been recognized that a similar approach can be applied to the data that depend on a length scale, such as velocity increments in fully developed turbulent flow, or height increments that characterize rough surfaces. A basic ingredient of the approach to the analysis of fluctuating data is the presence of a Markovian property, which can be detected in real systems above a certain time or length scale. This scale is referred to as the Markov-Einstein (ME) scale, and has turned out to be a useful characteristic of complex systems. We provide a review of the operational methods that have been developed for analyzing stochastic data in time and scale. We address in detail the following issues: (i) reconstruction of stochastic evolution equations from data in terms of the Langevin equations or the corresponding Fokker-Planck equations and (ii) intermittency, cascades, and multiscale correlation functions.

  20. Managing ground and surface water resources using innovative methods in rural and urban areas of Sub-Saharan Africa

    Science.gov (United States)

    Mapani, Benjamin; Magole, Lapologang; Makurira, Hodson; Mazvimavi, Dominic; Meck, Maideyi; Mul, Maloes

    2016-06-01

    Management of water resources across the world is becoming more challenging as a result of population increase and the changes in climatic patterns that are now evident across the globe, especially so in Southern Africa. It is therefore imperative that water researchers begin to apply innovative methods that are accurate and reliable. In this editorial we highlight some of the methods that have been applied in this changing environment.

  1. Methods for collection and analysis of aquatic biological and microbiological samples

    Science.gov (United States)

    Britton, L.J.; Greeson, P.E.

    1988-01-01

    Chapter A4, methods for collection and analyses of aquatic biological and microbiological samples, contains methods used by the U.S. Geological Survey to collect, preserve, and analyze waters to determine their biological and microbiological properties. Part 1 consists of detailed descriptions of more than 45 individual methods, including those for bacteria, phytoplankton, zooplankton, seston, periphyton, macrophytes, benthic invertebrates, fish and other vertebrates, cellular contents, productivity and bioassay. Each method is summarized, and the applications, interferences, apparatus, reagents, analyses, calculations, reporting of results, precisions, and references are given. Part 2 consists of a glossary. Part 3 is a list of taxonomic references. (USGS)

  2. A supplement to "Methods for collection and analysis of aquatic biological and microbiological samples"

    Science.gov (United States)

    1979-01-01

    The report contains methods used by the U.S. Geological Survey to collect, preserve, and analyze waters to determine their biological and microbiological properties. It supplements, "Methods for Collection and Analysis of Aquatic Biological and Microbiological Samples" (TWRI, Book 5, Chapter A4, 1977, edited by P. E. Greeson, T. A. Ehlke, G. A. Irwin, B. W. Lium, and K. V. Slack). Included in the supplement are 5 new methods, a new section of selected taxonomic references for Ostracoda, and 6 revised methods.

  3. Radical Financial Innovation

    OpenAIRE

    Robert J. Shiller

    2004-01-01

    Radical financial innovation is the development of new institutions and methods that permit risk management to be extended far beyond its former realm, covering important new classes of risks. This paper compares past such innovation with potential future innovation, looking at the process that produced past success and the possibilities for future financial innovation.

  4. Extreme Innovation

    OpenAIRE

    Sandmeier, Patricia; Gassmann, Oliver

    2006-01-01

    The article focuses on a study which examined the application of extreme programming methods to product innovation and development. Extreme programming is a process used in software engineering which deals with the fast changing customer requirements. The methodology used in the study is described. The study explored the challenges associated with product innovation structuring and management. The implications of the study findings for companies are highlighted.

  5. Steel Casing Resistivity Technology (SCRT): Innovative Applications of Electrical Methods for Buried Tank Leak Detection

    Science.gov (United States)

    Fink, J. B.; Levitt, M. T.; Gee, G. W.

    2002-12-01

    The need for non-invasive leak detection methods is extremely important for monitoring cleanup efforts of nuclear waste contained in underground storage tanks at the Hanford Nuclear Facility in Washington. Drilling is both very expensive and undesirable in the tank farms. Various geophysical imaging methods were evaluated over the past two years at two "cold" sites but within geologic conditions similar to the tank farms. The "cold" sites consisted of 1. a dense array of 32 steel casings, and 2. a "mock tank" in which various controlled leaks (injections) of a saturated aqueous solution of Na2S2O35H20 were metered. Nearly all methods required invasive drilling for subsurface placement of sensors. An innovative direct-current electrical method using existing infrastructure as grounding electrodes, such as steel casings and steel tanks, has shown very promising results and is undergoing further testing. The most useful results have been obtained by using multiple grounding points for spatial determinations and continuous time-series monitoring for temporal variations. Although the large size of tanks and lengths of casings make discrete volume estimations difficult, data acquired for test leaks to date have shown a surprising correlation between leak rates and the rate-of-change of specific electrical measurements. First order volume approximations can be made based on existing knowledge of the geologic environment and hydraulic parameters. Spatial data provide general leak location and gross flow characteristics, whereas temporal data indicate test leak commencement, cessation, and approximate leak rates. On-going testing is providing quantitative calibration information that is expected to transfer to the tank farm environments. Procedures are being developed that will simplify the installation and operation of the system in the tank-farm environments. Implementation of the technology necessitated remote operation and monitoring of the electrical system

  6. Priorities and developments of sensors, samplers and methods for key marine biological observations.

    Science.gov (United States)

    Simmons, Samantha; Chavez, Francisco; Pearlman, Jay

    2016-04-01

    Over the last two decades or more, physical oceanography has seen a significant growth in in-situ sensors and platforms including fixed point and cable observatories, Argo floats, gliders and AUVs to supplement satellites for creating a 3-D view of the time-varying global ocean temperature and salinity structures. There are important developments recently for biogeochemists for monitoring nitrate, chemical contaminants, oxygen and pH that can now be added to these autonomous systems. Biologists are still lagging. Given the importance of biology to ocean health and the future earth, and the present reliance on humans and ships for observing species and abundance, it is paramount that new biological sensor systems be developed. Some promising sensor systems based on, but not limited to acoustic, chemical, genomic or imaging techniques, can sense from microbes to whales, are on the horizon. These techniques can be applied in situ with either real time or recorded data and can be captured and returned to the laboratory using the autonomous systems. The number of samples is limiting, requiring adaptive and smart systems. Two steps are envisioned to meeting the challenges. The first is to identify the priority biological variables to focus observation requirements and planning. The second is to address new sensors that can fill the gaps in current capabilities for biological observations. This abstract will review recent efforts to identify core biological variables for the US Integrated Ocean Observing System and address new sensors and innovations for observing these variables, particularly focused on availability and maturity of sensors.

  7. Method And System For Examining Biological Materials Using Low Power Cw Excitation Raman Spectroscopy.

    Energy Technology Data Exchange (ETDEWEB)

    Alfano, Robert R. (Bronx, NY); Wang, Wubao (Flushing, NY)

    2003-05-06

    A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. A low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic transaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively.

  8. PROTEIN QUALITY EVALUATION OF NAKED OAT (AVENA NUDA L. AND BUCKWHEAT (FAGOPYRUM ESCULENTUM MOENCH BY BIOLOGICAL METHODS AND PDCAAS METHOD

    Directory of Open Access Journals (Sweden)

    Martina Vršková

    2013-02-01

    Full Text Available The aim of this paper was to determine the protein quality of naked oat (Avena nuda L. and buckwheat (Fagopyrum esculentum Moench by traditional biological methods [Protein Efficiency Ratio (PER, Net Protein Utilization (NPU, Biological value] and the protein digestibility-corrected amino acid score (PDCAAS. As an animal model we used growing rats at the age of 21 days and at average body weight 83 g. The tested feeds represented the only nitrogen source in the experimental diets, and the tested nitrogen substances were 10 % of the feed ration in dry matter. We found higher values achieved in growth, feed conversion and crude protein intake in the group fed buckwheat. Buckwheat achieved higher biological value. Oat achieved a higher digestibility, which was also influenced by higher PDCAAS. Buckwheat achieved higher biological protein value. Isoleucine was the limiting amino acid in both tested feeds. Other parameters of the evaluation of protein quality (PER, NPU had minimal differences.

  9. Innovative method and apparatus for the deep cleaning of soluble salts from mortars and lithic materials

    Science.gov (United States)

    Gaggero, Laura; Ferretti, Maurizio; Torrielli, Giulia; Caratto, Valentina

    2016-04-01

    demonstrated by conducibility tests on the juxtaposed Japanese paper. In addition, after the conventional treatment, a considerable amount of soluble salts was further extracted demonstrating that traditional wraps operate just a shallow cleaning, and soluble salts are liable to emerge later as efflorescence affecting the conservation after restoration. The optimum cleaning was obtained by finishing the innovative extraction with sepiolite/cellulose wraps. As a whole, the novel method and apparatus enhance the time for restoration and the final quality before consolidation and protection. [1] "Apparatus and method for treating porous materials" - M. Ferretti, L. Gaggero, G. Torrielli, PCT/IB2015/055129 (2015)

  10. Quantum chemical methods for the investigation of photoinitiated processes in biological systems: theory and applications.

    Science.gov (United States)

    Dreuw, Andreas

    2006-11-13

    With the advent of modern computers and advances in the development of efficient quantum chemical computer codes, the meaningful computation of large molecular systems at a quantum mechanical level became feasible. Recent experimental effort to understand photoinitiated processes in biological systems, for instance photosynthesis or vision, at a molecular level also triggered theoretical investigations in this field. In this Minireview, standard quantum chemical methods are presented that are applicable and recently used for the calculation of excited states of photoinitiated processes in biological molecular systems. These methods comprise configuration interaction singles, the complete active space self-consistent field method, and time-dependent density functional theory and its variants. Semiempirical approaches are also covered. Their basic theoretical concepts and mathematical equations are briefly outlined, and their properties and limitations are discussed. Recent successful applications of the methods to photoinitiated processes in biological systems are described and theoretical tools for the analysis of excited states are presented. PMID:17009357

  11. Analytical methods for vancomycin determination in biological fluids and in pharmaceuticals

    Directory of Open Access Journals (Sweden)

    Marta Maria Duarte Carvalho Vila

    2007-04-01

    Full Text Available Vancomycin is a glycopeptide antibiotic employed in the treatment of infections caused by certain methicillin-resistant staphylococci. It is indicated also for patients allergic to penicillin or when there is no response to penicillins or cephalosporins. The adequate vancomycin concentration levels in blood serum lies between 5 and 10 mg/L. Higher values are toxic, causing mainly nephrotoxicity and ototoxicity. Various analytical methods are described in the literature: spectrophotometric, immunologic, biologic and chromatographic methods. This paper reviews the main analytical methods for vancomycin determination in biological fluids and in pharmaceutical preparations.

  12. The phaseness of human biological development assesse with the use of selected physicochemical methods

    OpenAIRE

    Czapla, Zbigniew

    2000-01-01

    The principal idea of the work was to show a new, original method of description of the phenomena of human biological development with the use of nonstandard research methods so far unused in the ontogenetic studies in regard to the stable and involutional phases of ontogenesis. The main purpose of the work was to assess with selected methods individual reactions of a human organism in ontogenesis against the development of the population. Two research methods were selec...

  13. Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

    Directory of Open Access Journals (Sweden)

    Corina Mahu Ştefania

    2015-12-01

    Full Text Available Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such as liquid chromatography coupled with mass spectrometry, gas chromatography coupled with mass spectrometry, high performance liquid chromatography. Due to the complex composition of biological fluids a biological sample pre-treatment before the use of the method for quantitative determination is required in order to remove proteins and potential interferences. The most commonly used methods for processing biological samples containing metoprolol and bisoprolol were identified through a thorough literature search using PubMed, ScienceDirect, and Willey Journals databases. Articles published between years 2005-2015 were reviewed. Protein precipitation, liquid-liquid extraction and solid phase extraction are the main techniques for the extraction of these drugs from plasma, serum, whole blood and urine samples. In addition, numerous other techniques have been developed for the preparation of biological samples, such as dispersive liquid-liquid microextraction, carrier-mediated liquid phase microextraction, hollow fiber-protected liquid phase microextraction, on-line molecularly imprinted solid phase extraction. The analysis of metoprolol and bisoprolol in human plasma, urine and other biological fluids provides important information in clinical and toxicological trials, thus requiring the application of appropriate extraction techniques for the detection of these antihypertensive substances at nanogram and picogram levels.

  14. Glossary (for Measuring and Monitoring Biological Diversity: Standard Methods for Fungi)

    Science.gov (United States)

    Approximately 300 technical terms and 250 diagrammatic sketches and illustrations are provided for the Smithsonian Institution methods book, ‘Measuring and Monitoring Biological Diversity: Standard Methods for Fungi.’ Technical terms focus on traditional morphotaxonomy, ecology, and pathology. Als...

  15. Evaluation of gene association methods for coexpression network construction and biological knowledge discovery.

    Directory of Open Access Journals (Sweden)

    Sapna Kumari

    Full Text Available BACKGROUND: Constructing coexpression networks and performing network analysis using large-scale gene expression data sets is an effective way to uncover new biological knowledge; however, the methods used for gene association in constructing these coexpression networks have not been thoroughly evaluated. Since different methods lead to structurally different coexpression networks and provide different information, selecting the optimal gene association method is critical. METHODS AND RESULTS: In this study, we compared eight gene association methods - Spearman rank correlation, Weighted Rank Correlation, Kendall, Hoeffding's D measure, Theil-Sen, Rank Theil-Sen, Distance Covariance, and Pearson - and focused on their true knowledge discovery rates in associating pathway genes and construction coordination networks of regulatory genes. We also examined the behaviors of different methods to microarray data with different properties, and whether the biological processes affect the efficiency of different methods. CONCLUSIONS: We found that the Spearman, Hoeffding and Kendall methods are effective in identifying coexpressed pathway genes, whereas the Theil-sen, Rank Theil-Sen, Spearman, and Weighted Rank methods perform well in identifying coordinated transcription factors that control the same biological processes and traits. Surprisingly, the widely used Pearson method is generally less efficient, and so is the Distance Covariance method that can find gene pairs of multiple relationships. Some analyses we did clearly show Pearson and Distance Covariance methods have distinct behaviors as compared to all other six methods. The efficiencies of different methods vary with the data properties to some degree and are largely contingent upon the biological processes, which necessitates the pre-analysis to identify the best performing method for gene association and coexpression network construction.

  16. Marketing Innovations in Croatia

    OpenAIRE

    Ljiljana Božić

    2011-01-01

    The purpose of this paper is to analyze the introduction of marketing innovations by companies in Croatia. This study provides an insight into the innovativeness with regard to the introduction of marketing innovations. It explores the presence of marketing innovations in general and the introduction of four types of marketing innovation (significant changes to the aesthetic design or packaging, new media or techniques for product promotion, new methods for product placement or sales channels...

  17. Longwall mining “cutting cantilever beam theory” and 110 mining method in China—The third mining science innovation

    OpenAIRE

    Manchao He; Guolong Zhu; Zhibiao Guo

    2015-01-01

    With the third innovation in science and technology worldwide, China has also experienced this marvelous progress. Concerning the longwall mining in China, the “masonry beam theory” (MBT) was first proposed in the 1960s, illustrating that the transmission and equilibrium method of overburden pressure using reserved coal pillar in mined-out areas can be realized. This forms the so-called “121 mining method”, which lays a solid foundation for development of mining science and technology in Chin...

  18. Innovative methods to stabilize liquid membranes for removal of radionuclides from groundwater

    International Nuclear Information System (INIS)

    In this Phase I Small Business Innovation Research program, Membrane Technology Research, Inc., is developing a stable liquid membrane for extracting uranium and other radionuclides from groundwater. The improved membrane can also be applied to separation of other metal ions from aqueous streams in industrial operations

  19. Technological Foresight and Technology Assessment. Methods for Enabling Innovations in the Czech Republic

    Czech Academy of Sciences Publication Activity Database

    Machleidt, Petr

    Karlsruhe: Impressum - KIT, 2011 - (Banse, G.; Grunwald, A.; Hronszky, I.; Nelson, G.), s. 195-198 ISBN 978-3-86644-731-8 Institutional research plan: CEZ:AV0Z90090514 Keywords : society * public * science and technology * promotion of innovations Subject RIV: AA - Philosophy ; Religion

  20. Innovative methods to stabilize liquid membranes for removal of radionuclides from groundwater

    Energy Technology Data Exchange (ETDEWEB)

    Lokhandwala, K. [Membrane Technology and Research, Inc., Menlo Park, CA (United States)

    1997-10-01

    In this Phase I Small Business Innovation Research program, Membrane Technology Research, Inc., is developing a stable liquid membrane for extracting uranium and other radionuclides from groundwater. The improved membrane can also be applied to separation of other metal ions from aqueous streams in industrial operations.

  1. The effect of teaching methods on cognitive achievement, retention, and attitude among in biology studying

    Directory of Open Access Journals (Sweden)

    Snezana Stavrova Veselinovskaa

    2011-12-01

    Full Text Available The purpose of this paper is to determine the effects of usage of sequential teaching method on the academic achievement and retention level of students. Three student groups of biology students in University “Goce Delcev”, Faculty of Natural and Technical Sciences, Institute of Biology, - Stip, R. Macedonia were offered a topic on general characteristics of Proteins: Their Biological Functions and Primary Structure with different sequences of 3 teaching methods. The teaching methods were Laboratory method (student experiment, slide demonstration and lecture method. The first group started to course with experiments in the laboratory, then the relevant theory of proteins was given lecture method, and then the slides was shown (Group I. The sequence of these three teaching methods used in the first group was changed in both second and third group as follow: The lecture methods, slide show and experiment in Group II, and slide show, experiment and lecture method in Group III, respectively. Laboratory method used in the study was focused on the topic of this diversity and abundance reflect the central role of proteins in virtually all aspects of cell structure and function. Achievement test contained 20 questions, testing the knowledge of facts as well as the ability to transfer the knowledge and problem solving ability. This test was used as pre-test before methods’ application, post-test after the methods’ application and retention test after 30 days from methods’ applied.

  2. Texture analysis methods for the characterisation of biological and medical images

    Directory of Open Access Journals (Sweden)

    Ştefan Ţălu

    2012-06-01

    Full Text Available Adaptations can be extreme in many cases and they help organisms survive in their habitat or ecological niche. These adaptations can affect their anatomy, ethology or physiology. Anatomical adaptations are physical features such as animal's shape, particularities at the skeleton level, texture of exoskeleton, surface of the skin in animals or cuticula in plants etc. The purpose of this paper is to present a synthesis concerning the texture analysis methods used for the characterisation of biological and medical images. Texture analysis methods of biological and medical images provide noninvasive tools that allow biologists, physicians and researchers the early detection and diagnosis of diseases.

  3. Comments on "validation of two innovative methods to measure contaminant mass flux in groundwater" by Goltz et al.

    Science.gov (United States)

    Sun, Kerang

    2014-12-01

    I wish to comment on the paper published by Goltz et al. on this journal, titled Validation of two innovative methods to measure contaminant mass flux in groundwater (Goltz et al., 2009). The paper presents the results of experiments Goltz et al. conducted on an artificial aquifer for the purpose of validating two recently developed methods to measure contaminant mass flux in groundwater, the tandem circulation well (TCW) method and the modified integral pumping test (MIPT) method. Their experiment results showed that the TCW method implemented using both the multi-dipole technique and the tracer test technique successfully estimated the mass fluxes with respective accuracies within 2% and 16% of the known values. The MIPT method, on the other hand, underestimated the mass flux by as much as 70%. My comments focus on the MIPT method.

  4. Closed vessel microwave assisted extraction - An innovative method for determination of trace metals in plant materials

    Science.gov (United States)

    Oeztan, S.; Duering, R.-A.

    2012-04-01

    Determination of metal concentrations in plant samples is important for better understanding of effects of toxic metals that are biologically magnified through the food chain and compose a great danger to all living beings. In recent years the use of microwave assisted extraction for plant samples has shown tremendous research interest which will probably substitute conventional procedures in the future. Generally conventional procedures have disadvantages including consuming of time and solvents. The objective of this study is to investigate and compare a new closed vessel microwave extraction (MAE) method with the combination of EDTA (MAE-EDTA) for the determination of metal contents (Cd, Mn, Pb, Zn) in plant samples (Lolio-Cynosuretum) by ICP-OES. Validation of the method was done by comparison of the results with another MAE procedure (MAE-H) which is applied with the mixture of 69% nitric acid (HNO3) and 30% hydrogen peroxide (H2O2). Moreover, conventional plant extraction (CE) method, for which the dissolution of plant samples were handled in HNO3 after dry ashing at 420° C, was used as a reference method. Approximately 0.5 g of sample was digested in 5 ml HNO3, 3 ml H2O2, and 5 ml deionized H2O for MAE-H and in 8 ml EDTA solution for MAE-EDTA. Certified plant reference materials (CRMs) were used for comparison of recovery rates from different extraction protocols. Thereby, the applicability of both MAE-H and MAE-EDTA procedures could be demonstrated. For 58 plant samples MAE-H showed the same extraction yields as CE in the determination of trace metal contents of the investigated elements in plant samples. MAE-EDTA gave similar values when compared to MAE-H and highly linear relationships were found for determination of Cd, Mn, Pb and Zn amounts. The recoveries for the CRMs were within the range 89.6-115%. Finally, strategic characteristics of MAE-EDTA for determination metal contents (Cd, Mn, Pb, Zn) in plant samples are: (i) applicability to a large set

  5. Strategic Innovation Capacity: A Mixed Method Study on Deliberate Strategic Learning Mechanisms

    OpenAIRE

    Berghman, L.A.

    2006-01-01

    textabstractLiselore Berghman (ºAntwerp, May 3, 1977) received her Master’s degree in Applied Economics cum laude from the University of Antwerp (Belgium), where she is currently a research and teaching assistant at the Faculty of Applied Economics. Her research interests include strategic management and industrial marketing, especially the creation of radically innovative strategies. Her research has been published in international journals such as the Journal of Managerial Psychology and In...

  6. Synergetic Basis of Innovation Marketing

    OpenAIRE

    Melnyk, L.; Dehtyarova, I

    2012-01-01

    Issues of synergetic effects of innovation marketing are considered in the article. It shows sources of synergetic effects of innovation marketing, types of synergism, synergetic effects of marketing innovations, as well as evaluation methods.

  7. Innovation Methods Paved the Road of Innovation——Taking Geely as an Example%创新方法铺就创新之路——以吉利为例

    Institute of Scientific and Technical Information of China (English)

    张爱琴; 侯光明; 陈红

    2013-01-01

    先进的创新方法是提升国家自主创新能力的重要武器.吉利的创新成功与创新观念、创新方法、创新战略、创新管理有密切关系.以吉利为例,分析解读其在产品设计制造与管理创新中应用的创新方法,分析每种创新方法的选择决策与企业创新模式、创新战略、创新能力演变及企业家创新精神之间的关联.在此基础上,提出创新方法应用的经验和启示.%Advanced innovation method is an important weapon to enhance national indigenous innovative capacity. The success of Geely innovation is related to innovation conception, innovative method, innovation strategies, innovation management. Taking Geely as an example, the paper interpreted the application of innovation methods in product design and management innovation, and analyzed the association between the selection and decision of each innovation method and enterprise innovation mode, innovation strategy, innovation capability evolution, and entrepreneurial innovation spirit. On this basis, experience and inspiration of innovation method application were proposed.

  8. Innovation in san francisco.

    Science.gov (United States)

    Travis, J

    1992-08-01

    In San Francisco 2 weeks ago, AAAS and Science sponsored a new meeting, Science Innovation '92. The unusual gathering focused not on research results but on new techniques and instruments, particularly for biomedical science. As seen in the stories below, some of the most eye-catching innovations emerged at the intersection of physics and biology. PMID:17736460

  9. Improved Butanol-Methanol (BUME) Method by Replacing Acetic Acid for Lipid Extraction of Biological Samples.

    Science.gov (United States)

    Cruz, Mutya; Wang, Miao; Frisch-Daiello, Jessica; Han, Xianlin

    2016-07-01

    Extraction of lipids from biological samples is a critical step in lipidomics, especially for shotgun lipidomics where lipid extracts are directly infused into a mass spectrometer. The butanol-methanol (BUME) extraction method was originally developed to extract lipids from plasma samples with 1 % acetic acid. Considering some lipids are sensitive to acidic environments, we modified this protocol by replacing acetic acid with lithium chloride solution and extended the modified extraction to tissue samples. Although no significant reduction of plasmalogen levels in the acidic BUME extracts of rat heart samples was found, the modified method was established to extract various tissue samples, including rat liver, heart, and plasma. Essentially identical profiles of the majority of lipid classes were obtained from the extracts of the modified BUME and traditional Bligh-Dyer methods. However, it was found that neither the original, nor the modified BUME method was suitable for 4-hydroxyalkenal species measurement in biological samples. PMID:27245345

  10. Determination of element concentrations in biological reference materials by solid sampling and other analytical methods

    Energy Technology Data Exchange (ETDEWEB)

    Schauenburg, H.; Weigert, P. (Bundesgesundheitsamt, Berlin (Germany). Centre for Surveillance and Health Evaluation of Environmental Chemicals (ZEBS))

    1992-04-01

    Using solid sampling with graphite furnace atomic absorption spectrometry (GFAAS), values for cadmium, copper, lead and zinc in six biological reference materials were obtained from up to four laboratories participating in three collaborative studies. These results are compared with those obtained with other methods used in routine analysis from laboratories of official food control. Under certain conditions solid sampling with GFAAS seems to be suitable for routine analysis as well as conventional methods. (orig.).

  11. Method for detection of a suspect viral deoxyribonucleic acid in an acellular biological fluid

    International Nuclear Information System (INIS)

    A method for evaluating an acellular biological fluid for the presence of a suspect viral DNA, such as DNA of the Hepatitis-B virus, is described. The acellular biological fluid is treated to immobilize in denatured form the DNAs including the suspect viral DNA on a solid substrate. This substrate is contacted with a solution including radioisotopically-labelled suspect viral denatured DNA to renature the immobilized suspect viral native DNA. The solid substrate is then evaluated for radioisotopically-labelled suspect viral renatured DNA. (author)

  12. Heavy-metal air pollution study using biological indicators and nuclear analytical methods

    International Nuclear Information System (INIS)

    The development of industry and the increase in vehicle road traffic are responsible for the ever-growing environmental pollution by toxic elements. Some biological organisms strongly accumulate certain heavy toxic elements and thus can be considered as indicators of the environmental pollution. In this work different types of biological indicators were collected in almost all main cities and industrial zones of Vietnam. They were subsequently analysed by different modern analytical methods. The concentration of different elements and their correlation matrices may provide valuable information on the nature and sources of pollution (author)

  13. Sampling and sample preparation methods for the analysis of trace elements in biological material

    International Nuclear Information System (INIS)

    The authors attempt to give a most systamtic possible treatment of the sample taking and sample preparation of biological material (particularly in human medicine) for trace analysis (e.g. neutron activation analysis, atomic absorption spectrometry). Contamination and loss problems are discussed as well as the manifold problems of the different consistency of solid and liquid biological materials, as well as the stabilization of the sample material. The process of dry and wet ashing is particularly dealt with, where new methods are also described. (RB)

  14. Group Innovation Ability of Agricultural Technological Innovation Strategic Alliance

    Institute of Scientific and Technical Information of China (English)

    Chishun; MA; Jintian; YU

    2013-01-01

    Agricultural technological innovation strategic alliance, as an important form of strategic alliance, has steadily strengthened the collaborative management among organizations and raised competitive power with the backing of improved group innovation ability. This article studies innovation ability from individual innovation ability to the group innovation ability. Firstly, basic connotation of group innovation ability is to be concluded through the comparison of individual and group innovation ability. Secondly, evaluation index system is to be established based on the influencing factors of the group innovation ability of agricultural technological innovation strategic alliance and evaluation is based on three dimensions, namely organization technological innovation ability, alliance collaborative innovation ability as well as innovation environment. Furthermore, basic methods for promoting the group innovation ability of alliance are to be proposed.

  15. Best practices: implementation of a glucose screening program based on diffusion of innovation theory methods.

    Science.gov (United States)

    Nicol, Ginger E; Morrato, Elaine H; Johnson, Mark C; Campagna, Elizabeth; Yingling, Michael D; Pham, Victor; Newcomer, John W

    2011-01-01

    There is public health interest in the identification and treatment of modifiable cardiometabolic risk factors among patients treated with antipsychotic medications. However, best-practice screening recommendations endorsed by multiple medical organizations have not translated into real-world clinical practice. Quality improvement strategies may help to address the gap between policy and implementation. This column describes the successful implementation of a best-practice glucose screening program in a large network of community mental health centers that was based on Six Sigma and diffusion of innovation theory. PMID:21209293

  16. An innovative method of generating current and thermoelectric equipment for its realization

    International Nuclear Information System (INIS)

    The paper assesses an innovative thermoelectric device used to generate a current by the conversion of thermal energy into electrical energy. The device has been created and verified. Until now, the efficiency of conventional thermoelectric batteries is for technical practice not sufficiently appreciated, because it does not exceed 3 %. A necessary condition needed for the implementation of the Seebeck thermoelectric effect is a sufficient and stable source of heat that provides an optimum temperature difference, but there are two other sufficient conditions for a significant increase in efficiency of thermoelectric batteries. These are concerned with the development of new materials for thermoelectric batteries and with the development of new construction of thermoelectric batteries

  17. Potential of the PIGE method in the analysis of biological and mineral materials

    International Nuclear Information System (INIS)

    A possible application of the PIGE method for the analysis of the biological and mineral samples has been tested using a 3.5 MeV Van de Graaff accelerator. The limits of detection of 4 mg/kg for fluorine, 10 mg/kg for aluminium and 200 mg/kg for phosphorus were achieved with a 3.15 MeV proton beam (8 mm in diameter, 20 nA current and 1000 s irradiation time). The PIGE method was found to be a suitable method for the determination of fluorine in the samples analyzed. With this technique, total fluorine in the sample can be quantitated without any chemical treatment. In the analysis of the phosphorus in thick biological samples, PIGE can compete with PIXE and is probably less sensitive to matrix effects and spectra fitting, which may bring about a higher accuracy of the results

  18. Determination of chorionic gonadotrophin. Comparison of biological, immunological and radioimmunological methods

    International Nuclear Information System (INIS)

    Three types of analysis were used to quantify chorionic gonadotrophic hormone: biological determination (rana-reaction); immunological determination (simplified pregnosticon test of the Organon Teknika laboratories); radioimmunological determination (Commissariat a l'Energie Atomique - CEA kits). While the immunochemical technique is specially suited to analysis of the urine, the radioimmunological measurement is carried out on the plasma. This method is extremely sensitive; when traditional biological and immunological methods are used the quantity of CGH detectable is of the order of some hundreds or at best a few tens of international units. The radioimmunological method is a thousand times more sensitive and can therefore measure CGH in amounts of the milli-unit order. Until recently it was not specific enough to differentiate between CGH and LH, but not long ago a β CGH-specific antibody was discovered and it is now possible to detect small amounts of CGH in the presence of LH

  19. EBP2R - an innovative enhanced biological nutrient recovery activated sludge system to produce growth medium for green microalgae cultivation.

    Science.gov (United States)

    Valverde-Pérez, Borja; Ramin, Elham; Smets, Barth F; Plósz, Benedek Gy

    2015-01-01

    Current research considers wastewater as a source of energy, nutrients and water and not just a source of pollution. So far, mainly energy intensive physical and chemical unit processes have been developed to recover some of these resources, and less energy and resource demanding alternatives are needed. Here, we present a modified enhanced biological phosphorus removal and recovery system (referred to as EBP2R) that can produce optimal culture media for downstream micro-algal growth in terms of N and P content. Phosphorus is recovered as a P-stream by diversion of some of the effluent from the upstream anaerobic reactor. By operating the process at comparably low solids retention times (SRT), the nitrogen content of wastewater is retained as free and saline ammonia, the preferred form of nitrogen for most micro-algae. Scenario simulations were carried out to assess the capacity of the EBP2R system to produce nutrient rich organic-carbon depleted algal cultivation media of target composition. Via SRT control, the quality of the constructed cultivation media can be optimized to support a wide range of green micro-algal growth requirements. Up to 75% of the influent phosphorus can be recovered, by diverting 30% of the influent flow as a P-stream at an SRT of 5 days. Through global sensitivity analysis we find that the effluent N-to-P ratio and the P recovered are mainly dependent on the influent quality rather than on biokinetics or stoichiometry. Further research is needed to demonstrate that the system performance predicted through the model-based design can be achieved in reality. PMID:25480432

  20. Mollified birth in natural-age-grid Galerkin methods for age-structured biological systems

    International Nuclear Information System (INIS)

    We present natural-age-grid Galerkin methods for a model of a biological population undergoing aging. We use a mollified birth term in the method and analysis. The error due to mollification is of arbitrary order, depending on the choice of mollifier. The methods in this paper generalize the methods presented in [1], where the approximation space in age was taken to be a discontinuous piecewise polynomial subspace of L2. We refer to these methods as 'natural-age-grid' Galerkin methods since transport in the age variable is computed through the smooth movement of the age grid at the natural dimensionless velocity of one. The time variable has been left continuous to emphasize this smooth motion, as well as the independence of the time and age discretizations. The methods are shown to be superconvergent in the age variable

  1. Trends in IT Innovation to Build a Next Generation Bioinformatics Solution to Manage and Analyse Biological Big Data Produced by NGS Technologies

    Science.gov (United States)

    de Brevern, Alexandre G.; Meyniel, Jean-Philippe; Fairhead, Cécile; Neuvéglise, Cécile; Malpertuy, Alain

    2015-01-01

    Sequencing the human genome began in 1994, and 10 years of work were necessary in order to provide a nearly complete sequence. Nowadays, NGS technologies allow sequencing of a whole human genome in a few days. This deluge of data challenges scientists in many ways, as they are faced with data management issues and analysis and visualization drawbacks due to the limitations of current bioinformatics tools. In this paper, we describe how the NGS Big Data revolution changes the way of managing and analysing data. We present how biologists are confronted with abundance of methods, tools, and data formats. To overcome these problems, focus on Big Data Information Technology innovations from web and business intelligence. We underline the interest of NoSQL databases, which are much more efficient than relational databases. Since Big Data leads to the loss of interactivity with data during analysis due to high processing time, we describe solutions from the Business Intelligence that allow one to regain interactivity whatever the volume of data is. We illustrate this point with a focus on the Amadea platform. Finally, we discuss visualization challenges posed by Big Data and present the latest innovations with JavaScript graphic libraries. PMID:26125026

  2. Methods to examine reproductive biology in free-ranging, fully-marine mammals.

    Science.gov (United States)

    Lanyon, Janet M; Burgess, Elizabeth A

    2014-01-01

    Historical overexploitation of marine mammals, combined with present-day pressures, has resulted in severely depleted populations, with many species listed as threatened or endangered. Understanding breeding patterns of threatened marine mammals is crucial to assessing population viability, potential recovery and conservation actions. However, determining reproductive parameters of wild fully-marine mammals (cetaceans and sirenians) is challenging due to their wide distributions, high mobility, inaccessible habitats, cryptic lifestyles and in many cases, large body size and intractability. Consequently, reproductive biologists employ an innovative suite of methods to collect useful information from these species. This chapter reviews historic, recent and state-of-the-art methods to examine diverse aspects of reproduction in fully-aquatic mammals. PMID:25091913

  3. Piglets born from handmade cloning, an innovative cloning method without micromanipulation

    DEFF Research Database (Denmark)

    Du, Y.; Kragh, P.M.; Zhang, Y.;

    2007-01-01

    Porcine handmade cloning (HMC), a simplified alternative of micromanipulation based traditional cloning (TC) has been developed in multiple phases during the past years, but the final evidence of its biological value, births of piglets was missing. Here we report the first births of healthy piglets...

  4. Registration methods of the differential X-ray projections of biological objects

    International Nuclear Information System (INIS)

    The image contrast improvement conditions for biological objects at X-ray projections digital deduction obtained at spectrum varying within energy range 5-25 keV are considered. It is shown, that developed methods for spectral lines selection with help of semi-transparent X-ray monochromators may be used for X-ray differential images dynamical visualization problem solution. The practical opportunities of the differential method are demonstrated with help of the projection scheme on the base of selective filters and standard X-ray tube which qualitatively simulating the spectrum transformation. Comparison of the differential method with phase contrast way is conducted

  5. Application of radiochemical methods for development of new biological preparation designed for soil bioremediation

    International Nuclear Information System (INIS)

    Full text: Internationally the bioremediation of agricultural lands contaminated by persistent chloroorganic compounds by means of the microbial methods are used as the most low-cost and the most effective. One of the factors reducing efficacy of microbial degradation, is often the low quantity of microorganisms - destructors in the soil. Therefore, we have designed bioremediation technology of soils, contaminated by organochlorine compounds, with use of the alive microorganisms as active agent. We developed the biological preparation containing 5 aboriginal active strains of bacteria - destructors of persistent chloroorganic compounds and investigated the ability of biological preparation to increase the bioremediation potential of contaminated soils. To carry out the investigation we developed the complex of radiochemical methods with use of tritium labeled PCBs, including the following methods: 1.The method to define the accumulation and degradation of PCBs in soil bacteria in culture allows determination of quantitative characteristics of bacterial strains. 2. The method to define the PCBs degradation by soil bacteria strains in model conditions in the soil allows to estimate the PCB-destructive activity of strains after introducing in soil. 3. A method to define the PCB-destructive activity of own microbiota of contaminated soil. 4. A method to define the effect of stimulation of the PCB-destructive activity of biological preparation and own microbiota of soil with the help of biofertilizers. By using the developed radiochemical methods we have carried out investigation on creation of new biological preparation on the basis of strains of soil bacteria - destructors of PCBs. We also determined the quality and quantity characteristics of HCCH and PCBs-destructive activity of new biological preparation. It is shown that the new biological preparation is capable of accumulation and destruction of the PCBs in culture and in soil at model conditions. Thus, the

  6. Turn of the century refueling: A review of innovations in early gasoline refueling methods and analogies for hydrogen

    International Nuclear Information System (INIS)

    During the first decades of the 20th century, a variety of gasoline refueling methods supported early US gasoline vehicles and successfully alleviated consumer concerns over refueling availability. The refueling methods employed included cans, barrels, home refueling outfits, parking garage refueling facilities, mobile stations, hand carts and curb pumps. Only after robust markets for gasoline vehicles had been firmly established did the gasoline service station become the dominant refueling method. The present study reviews this history and draws analogies with current and future efforts to introduce hydrogen as a fuel for vehicles. These comparisons hold no predictive power; however, there is heuristic value in an historical review of the first successful and large-scale introduction of a vehicle fuel. From an energy policy perspective, these comparisons reinforce the importance of a long-term and portfolio approach to support for technology development and innovation

  7. New improved method for evaluation of growth by food related fungi on biologically derived materials

    DEFF Research Database (Denmark)

    Bergenholtz, Karina P.; Nielsen, Per Væggemose

    2002-01-01

    Biologically derived materials, obtained as commercial and raw materials (Polylactate (PLA), Polyhydroxybutyrate (PHB), potato, wheat and corn starch) were tested for their ability to support fungal growth using a modified ASTM G21-96 (American Society for Testing and Materials) standard as well as...... a new method where 10 mul of a spore suspension is placed in a spot on the test sample. The new method gave additional information about fungal growth on biologically derived materials, revealing a clear difference between survival and growth. PHB and PIA turned out to be most suitable for food...... packaging application as no significant growth was seen within 28 d of incubation at 30 degreesC....

  8. Metrological assessment of the high-accuracy RNAA method of co-determination in biological materials

    International Nuclear Information System (INIS)

    The paper summarizes work on the development of the high-accuracy RNAA method for the determination of trace amounts of cobalt in biological materials. The method is based on a combination of neutron activation with selective and quantitative isolation of the analyte in a state of high radiochemical purity by use of column chromatography followed by gamma-ray spectrometric measurements. The method was devised according to a set of rules, which were formulated to obtain high accuracy of the method. The procedure has been also equipped with several criteria, being a key factor of quality assurance. The qualification of the high-accuracy RNAA method as a primary ratio method has been demonstrated and its usefulness in the certification of the candidate reference materials: Tea Leaves and Mixed Polish Herbs is presented. (author)

  9. Erika oil spill : some innovations in the French shoreline response and beach cleanup methods

    International Nuclear Information System (INIS)

    This paper described the main phases of the Erika shoreline cleaning operation. The Erika tanker sank off the southern coast of France on December 12, 1999, spilling an estimated 20,000 tons of Bunker C fuel that was left to drift and weather at sea for more than 10 days through severe sea conditions. More than 400 km of shoreline was affected by the oil. This included sandy and rocky shores, dunes, cliffs, marshes, muddy flats as well as highly anthropogenic shoreline. Most of the oil was removed between December 24, 1999 and the end of January 2000, although cleaning operations continued. There were many innovations in the French oil spill organization in the area of shoreline response. The polluter, TotalFinaElf, accepted a moral obligation to succeed and to use whatever means needed to do so. The company was instrumental in developing collaboration between response workers from private companies and POLMAR (state) workers, consisting of non-specialized and frequently relieved personnel from the military and fire fighting units. TotalFinaElf used environmental expertise to define the cleaning procedures and to decide when beaches could be opened for recreational use. Call for tenders were put out for beach and cleaning operations. The major innovation in this response was the hiring of professional climbers to work at sites that were difficult to access. Specific botanical work sites were delineated and quads and specific geotextile sheets were used to limit the degradation of terrestrial vegetation. Rocks were cleaned with hot water without pressure and anchored fishing nets were used to catch drifting oil. 1 ref

  10. Methods for the synthesis of aza(deaza)xanthines as a basis of biologically active compounds

    Science.gov (United States)

    Babkov, D. A.; Geisman, A. N.; Khandazhinskaya, A. L.; Novikov, M. S.

    2016-03-01

    The review covers methods for the synthesis of aza(deaza)xanthines, i.e., fused pyrrolo-, pyrazolo- and triazolopyrimidine heterocyclic systems, which are common core structures of various biologically active compounds. The extensive range of modern synthetic approaches is organized according to target structures and starting building blocks. The presented material is intended to benefit broad audience of specialists in the fields of organic, medicinal and pharmaceutical chemistry. The bibliography includes 195 references.

  11. Preparation of Biological Samples Containing Metoprolol and Bisoprolol for Applying Methods for Quantitative Analysis

    OpenAIRE

    Corina Mahu Ştefania; Monica Hăncianu; Luminiţa Agoroaei; Anda Cristina Coman Băbuşanu; Elena Butnaru

    2015-01-01

    Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such as liquid chromatography coupled with mass spectrometry, gas chromatography coupled with mass spectrometry, high performance liquid chromatography. ...

  12. COMPARISON OF TWO BIOLOGICAL METHODS FOR ASSESSMENT OF RIVER WATER QUALITY BASED ON MACROZOOBENTHOS

    OpenAIRE

    Mladen Kerovec; Zlatko Mihaljević

    2010-01-01

    In the present paper, the results of two macrozoobenthos analysis based indices (Saprobic Index and Extended Biotic Index) are used as biological indicators in the assessment of river water quality. The objective of the paper is to establish the extent to which the results of these methods are comparable. The results indicate that both indices are suitable for assessing the quality of river water in the Croatian hydrographic network. Major deviations were only detected in xenosaprobic waters,...

  13. Structural characterization of chitin and chitosan obtained by biological and chemical methods.

    Science.gov (United States)

    Pacheco, Neith; Garnica-Gonzalez, Mónica; Gimeno, Miquel; Bárzana, Eduardo; Trombotto, Stéphane; David, Laurent; Shirai, Keiko

    2011-09-12

    Chitin production was biologically achieved by lactic acid fermentation (LAF) of shrimp waste (Litopenaeus vannameii) in a packed bed column reactor with maximal percentages of demineralization (D(MIN)) and deproteinization (D(PROT)) after 96 h of 92 and 94%, respectively. This procedure also afforded high free astaxanthin recovery with up to 2400 μg per gram of silage. Chitin product was also obtained from the shrimp waste by a chemical method using acid and alkali for comparison. The biologically obtained chitin (BIO-C) showed higher M(w) (1200 kDa) and crystallinity index (I(CR)) (86%) than the chemically extracted chitin (CH-C). A multistep freeze-pump-thaw (FPT) methodology was applied to obtain medium M(w) chitosan (400 kDa) with degree of acetylation (DA) ca. 10% from BIO-C, which was higher than that from CH-C. Additionally, I(CR) values showed the preservation of crystalline chitin structure in BIO-C derivatives at low DA (40-25%). Moreover, the FPT deacetylation of the attained BIO-C produced chitosans with bloc copolymer structure inherited from a coarse chitin crystalline morphology. Therefore, our LAF method combined with FPT proved to be an affective biological method to avoid excessive depolymerization and loss of crystallinity during chitosan production, which offers new perspective applications for this material. PMID:21790136

  14. A Novel Biological Dosimetry Method for Monitoring Occupational Radiation Exposure in Diagnostic and Therapeutic Wards: From Radiation Dosimetry to Biological Effects

    OpenAIRE

    Heydarheydari, S.; Haghparast, A.; Eivazi, M.T.

    2016-01-01

    Background and Objective Professional radiation workers are occupationally exposed to long-term low levels of ionizing radiation. Occupational health hazards from radiation exposure, in a large occupational segment of the population, are of special concern. Biological dosimetry can be performed in addition to physical dosimetry with the aim of individual dose assessment and biological effects. Methods In this biodosimetry study, some hematological parameters have been examined in 40 exposed a...

  15. Comparative systems biology between human and animal models based on next-generation sequencing methods

    Institute of Scientific and Technical Information of China (English)

    Yu-Qi ZHAO; Gong-Hua LI; Jing-Fei HUANG

    2013-01-01

    Animal models provide myriad benefits to both experimental and clinical research.Unfortunately,in many situations,they fall short of expected results or provide contradictory results.In part,this can be the result of traditional molecular biological approaches that are relatively inefficient in elucidating underlying molecular mechanism.To improve the efficacy of animal models,a technological breakthrough is required.The growing availability and application of the high-throughput methods make systematic comparisons between human and animal models easier to perform.In the present study,we introduce the concept of the comparative systems biology,which we define as "comparisons of biological systems in different states or species used to achieve an integrated understanding of life forms with all their characteristic complexity of interactions at multiple levels".Furthermore,we discuss the applications of RNA-seq and ChIP-seq technologies to comparative systems biology between human and animal models and assess the potential applications for this approach in the future studies.

  16. Optimized and validated spectrophotometric methods for the determination of nicorandil in drug formulations and biological fluids.

    Science.gov (United States)

    Rahman, Nafisur; Ahmad Khan, Nadeem; Hejaz Azmi, Syed Najmul

    2004-07-01

    Two simple, sensitive and economical spectrophotometric methods have been developed for the determination of nicorandil in drug formulations and biological fluids. Method A is based on the reaction of the drug with brucine-sulphanilic acid reagent in sulphuric acid medium producing a yellow-coloured product, which absorbs maximally at 410 nm. Method B depends on the formation of the intensely blue-coloured product which results due to the interaction of an electrophilic intermediate of 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) with oxidized product of 4-(methyl amino) phenol sulphate (metol) in the presence of nicorandil as an oxidizing agent in sulphuric acid medium. The coloured product shows absorbance maximum at 560 nm. Under the optimized experimental conditions, Beer's law is obeyed in the concentration range of 2.5-35.0 and 0.40-2.2 microg ml(-1) for Methods A and B, respectively. Both the methods have been successfully applied to the determination of nicorandil in drug formulations and biological fluids. The results are validated statistically and through recovery studies. In order to establish the bias and the performance of the proposed methods, the point and interval hypothesis tests have been performed. The experimental true bias of all samples is smaller than +/-2%. PMID:15231427

  17. 生物科学本科生科研创新能力的培养%Cultivation of Scientific Innovation Ability of Biological Science Major Undergraduates

    Institute of Scientific and Technical Information of China (English)

    刘超; 洪法水

    2012-01-01

    Scientific practices are an important pathway to promote innovation abilities of biology science major undergraduates. With the support of National New Ideas Foundation of undergraduates and Soochow University New Ideas Foundation of Student and Academic Research Project of Student, undergraduate students are trained to accomplish systemic scientific researches, including cultivation of research interests, trainings of literature retrieval, trainings of experimental design and skills, trainings of experimental result analysis, trainings of academic paper writings, and trainings of scientific research qualities etc, by the instructions of teachers. Scientific practices not only achieved students' s mastery, through a comprehensive study of their basic knowledge, but also promoted their innovative abilities to observe,discover and solve problems. In the past five years,the undergraduates in the lab have published 16 scientific papers in SCI( E) source journals as first author or co-first author,and participated other 21 scientific papers publication in SCI(E) source journals. The total impact factors of these papers add up to 61.41.%结合国家级、校级大学生创新性实验计划和大学生课外学术科研基金等项目,在指导教师系统教导下,对本科生进行科研训练.包括科研兴趣培养,文献检索和阅读训练,实验设计训练,实验技能训练,实验结果记录和分析训练,科技论文撰写训练,科研素质训练等等.通过本科生科研实践不但促进了专业基础理论知识的融会贯通,还提高了发现问题、分析问题、解决问题的能力,增强学生科研创新能力.

  18. EFFECT OF CORPORATE INNOVATION ABILITY ON THE CHOICE BETWEEN PRODUCT INNOVATION AND PROCESS INNOVATION

    OpenAIRE

    Zeng Wu; Tian Zhilong

    2010-01-01

    With the method of duopoly game theory, the effect of firms’ innovation ability on the choice between product and process innovation is studied. The concept of cost coefficient of product innovation is introduced, and the criterion equation for the innovation type is derived. The following conclusions are made: the more the product innovation ability, the more the possibility for the firms to carry out the product innovation in both the Bertrand and the Cournot competitions. Wi...

  19. Traveling wave solutions of a biological reaction-convection-diffusion equation model by using $(G'/G$ expansion method

    Directory of Open Access Journals (Sweden)

    Shahnam Javadi

    2013-07-01

    Full Text Available In this paper, the $(G'/G$-expansion method is applied to solve a biological reaction-convection-diffusion model arising in mathematical biology. Exact traveling wave solutions are obtained by this method. This scheme can be applied to a wide class of nonlinear partial differential equations.

  20. A method combining simulation models and on farm surveys for ex ante assessment of agro-ecological innovations

    OpenAIRE

    Blazy, Jean-Marc; Ozier Lafontaine, Harry; Thomas, Alban; Meynard, Jean Marc,; Wery, Jacques

    2010-01-01

    Agro-ecological innovations are needed to reduce the impacts of current intensive agricultural practices on biodiversity and ecosystems. Whereas many published studies focus on the biophysical impacts of such innovations at field level, few attention has been given to the analysis of the potential of adoption of these innovations at farm and regional levels. In order to reduce the gap between on station and in silico innovation and farmer’s adoption process, we developped an interdisciplinary...

  1. Biological optimization systems for enhancing photosynthetic efficiency and methods of use

    Energy Technology Data Exchange (ETDEWEB)

    Hunt, Ryan W.; Chinnasamy, Senthil; Das, Keshav C.; de Mattos, Erico Rolim

    2012-11-06

    Biological optimization systems for enhancing photosynthetic efficiency and methods of use. Specifically, methods for enhancing photosynthetic efficiency including applying pulsed light to a photosynthetic organism, using a chlorophyll fluorescence feedback control system to determine one or more photosynthetic efficiency parameters, and adjusting one or more of the photosynthetic efficiency parameters to drive the photosynthesis by the delivery of an amount of light to optimize light absorption of the photosynthetic organism while providing enough dark time between light pulses to prevent oversaturation of the chlorophyll reaction centers are disclosed.

  2. A Fast Radiochemical Method for the Determination of Some Essential Trace Elements in Biology and Medicine

    International Nuclear Information System (INIS)

    A method has been developed for the determination with neutron-activation analysis of the following trace elements in soft biological tissues: Br, Ca, Cl, Cu, K, Mg, Mn, Mo, Na, P, Sr and Zn. The method consists in performing a short-term irradiation of the samples with a high thermal neutron flux, followed by fast chemical separations and gamma-spectrometric measurements. The chemical separations and the measurements of short-lived nuclides from a run are finished within 70 min, after the end of irradiation

  3. The Trial of Drug Discovery using the In-Silico Screening Methods Developed by Pharmaceutical Innovation Value Chain

    Science.gov (United States)

    Inoue, Tsuyoshi; Matsumura, Hiroyoshi; Adachi, Hiroaki; Mori, Yusuke; Takano, Kazufumi; Murakami, Satoshi; Fukunishi, Yoshifumi; Nakamura, Haruki; Kinoshita, Takayoshi; Nakanishi, Isao; Okuno, Yasushi; Minakata, Satoshi; Mikami, Yoshiaki; Sakuma, Toshihiro; Kitajima, Masato; Fukuoka, Yoshitada; Takada, Toshikazu; Sakata, Tsuneaki

    We have recently established Pharmaceutical Innovation Value Chain collaborated by The SOSHO project (http://www.so-sho.jp) and The BioGrid Project (http://www.biogrid.jp/) to accelerate new drug development. The in-silico group calculated the matrices on the interaction between the proteins and chemical compounds, and developed the novel in-silico screening methods, Multiple Target Screening (MTS) and Docking score index (DSI), improving the hit rate of screening a lead compound. We have applied these methods for the two target enzymes; human hematopoietic prostaglandin D synthase (H-PGDS) and orotidine 5’-monophosphate decarboxylase from human malaria parasite plasmodium falciparum (PfOMPDC). The optimizing of HQL-79, one of the known inhibitors for human H-PGDS and the screening of lead compounds for both enzymes are in study.

  4. Evaluation of a gas chromatography method for azelaic acid determination in selected biological samples

    Directory of Open Access Journals (Sweden)

    Mahdi Garelnabi

    2010-09-01

    Full Text Available Background: Azelaic acid (AzA is the best known dicarboxilic acid to have pharmaceutical benefits and clinical applications and also to be associated with some diseases pathophysiology. Materials and Methods: We extracted and methylesterified AzA and determined its concentration in human plasma obtained from healthy individuals and also in mice fed AzA containing diet for three months. Results: AzA was detected in Gas Chromatography (GC and confirmed by Liquid chromatography mass spectrometry (LCMS, and gas chromatography mass spectrometry (GCMC. Our results have shown that AzA can be determined efficiently in selected biological samples by GC method with 1nM limit of detection (LoD and the limit of quantification (LoQ; was established at 50nM. Analytical Sensitivity as assayed by hexane demonstrated an analytical sensitivity at 0.050nM. The method has demonstrated 8-10% CV batch repeatability across the sample types and 13-18.9% CV for the Within-Lab Precision analysis. The method has shown that AzA can efficiently be recovered from various sample preparation including liver tissue homogenate (95% and human plasma (97%. Conclusions: Because of its simplicity and lower limit of quantification, the present method provides a useful tool for determining AzA in various biological sample preparations.

  5. Logistic innovations in transport

    Directory of Open Access Journals (Sweden)

    Mirosław Antonowicz

    2014-03-01

    Full Text Available Introduction: The article discusses the issue of logistic innovations in transport. The essentials of logistic innovations in transport together with some examples of specific innovations are presented. The role of the client's needs in transport innovations is indicated. The most vital postulates affecting the innovativeness of shipping companies and derived from the author's experience as well as scholarly publications, are time, safety, reliability as well as comprehensiveness of service offer. Following the analysis of the issue, and on the grounds of Kaizen's and Lean's method, the concept of continuous innovations is suggested as very useful for the development of transport. The potential of clusters as the source of logistic innovations in transport is emphasised. Methods: The discussion of the issue was preceded by the author's analysis of written sources on innovativeness, the evaluation of ratings of innovativeness as well as the analysis of rewarded innovative solutions in transport subsequent to the businesses participation in the programme of innovative solutions in transport. The role of innovation practical business operations is argued following the analysis of some strategic documents such as: 2011 White Paper and the Strategy for the Development of Transport by 2020 adopted by the Polish government in 2013. Aim: The aim of the article is to present the role and significance of the issue of logistic innovations in transport and to cite instances of practical solutions implemented by shipping companies, the solutions which resulted in measurable effects. Following the author's observation of the instances of innovative solutions as well as his analysis of the ratings of innovativeness, the article aims to present the conclusions as for the specific kinds of activities which are indispensable to foster innovativeness in transport. Conclusions: The conclusions derived from the author's analyses and observations show that logistic

  6. Green Jobs: Definition and Method of Appraisal of Chemical and Biological Risks.

    Science.gov (United States)

    Cheneval, Erwan; Busque, Marc-Antoine; Ostiguy, Claude; Lavoie, Jacques; Bourbonnais, Robert; Labrèche, France; Bakhiyi, Bouchra; Zayed, Joseph

    2016-04-01

    In the wake of sustainable development, green jobs are developing rapidly, changing the work environment. However a green job is not automatically a safe job. The aim of the study was to define green jobs, and to establish a preliminary risk assessment of chemical substances and biological agents for workers in Quebec. An operational definition was developed, along with criteria and sustainable development principles to discriminate green jobs from regular jobs. The potential toxicity or hazard associated with their chemical and biological exposures was assessed, and the workers' exposure appraised using an expert assessment method. A control banding approach was then used to assess risks for workers in selected green jobs. A double entry model allowed us to set priorities in terms of chemical or biological risk. Among jobs that present the highest risk potential, several are related to waste management. The developed method is flexible and could be adapted to better appraise the risks that workers are facing or to propose control measures. PMID:26718400

  7. Innovative test method for the estimation of the foaming tendency of substrates for biogas plants

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, Lucie, E-mail: lucie.moeller@ufz.de [UFZ – Helmholtz Centre for Environmental Research, Centre for Environmental Biotechnology, Permoserstrasse 15, 04318 Leipzig (Germany); Eismann, Frank, E-mail: info@antoc.de [Eismann & Stöbe GbR, GeoPark, Geb. A12, Bautzner Strasse 67, 04347 Leipzig (Germany); Wißmann, Daniel, E-mail: d.s.wissmann@gmx.de [University of Hohenheim, State Institute of Agricultural Engineering and Bioenergy (LA740), Garbenstrasse 9, 70599 Stuttgart (Germany); Nägele, Hans-Joachim, E-mail: hajo.naegele@uni-hohenheim.de [University of Hohenheim, State Institute of Agricultural Engineering and Bioenergy (LA740), Garbenstrasse 9, 70599 Stuttgart (Germany); Zielonka, Simon, E-mail: simon.zielonka@uni-hohenheim.de [University of Hohenheim, State Institute of Agricultural Engineering and Bioenergy (LA740), Garbenstrasse 9, 70599 Stuttgart (Germany); Müller, Roland A., E-mail: roland.mueller@ufz.de [UFZ – Helmholtz Centre for Environmental Research, Centre for Environmental Biotechnology, Permoserstrasse 15, 04318 Leipzig (Germany); Zehnsdorf, Andreas, E-mail: andreas.zehnsdorf@ufz.de [UFZ – Helmholtz Centre for Environmental Research, Centre for Environmental Biotechnology, Permoserstrasse 15, 04318 Leipzig (Germany)

    2015-07-15

    Graphical abstract: Display Omitted - Highlights: • Foaming in biogas plants depends on the interactions between substrate and digestate. • Foaming tests enable the evaluation of substrate foaming tendency in biogas plants. • Leipzig foam tester enables foaming tests of substrates prior to use. - Abstract: Excessive foaming in anaerobic digestion occurs at many biogas plants and can cause problems including plugged gas pipes. Unfortunately, the majority of biogas plant operators are unable to identify the causes of foaming in their biogas reactor. The occurrence of foaming is often related to the chemical composition of substrates fed to the reactor. The consistency of the digestate itself is also a crucial part of the foam formation process. Thus, no specific recommendations concerning substrates can be given in order to prevent foam formation in biogas plants. The safest way to avoid foaming is to test the foaming tendency of substrates on-site. A possible solution is offered by an innovative foaming test. With the help of this tool, biogas plant operators can evaluate the foaming disposition of new substrates prior to use in order to adjust the composition of substrate mixes.

  8. Innovative test method for the estimation of the foaming tendency of substrates for biogas plants

    International Nuclear Information System (INIS)

    Graphical abstract: Display Omitted - Highlights: • Foaming in biogas plants depends on the interactions between substrate and digestate. • Foaming tests enable the evaluation of substrate foaming tendency in biogas plants. • Leipzig foam tester enables foaming tests of substrates prior to use. - Abstract: Excessive foaming in anaerobic digestion occurs at many biogas plants and can cause problems including plugged gas pipes. Unfortunately, the majority of biogas plant operators are unable to identify the causes of foaming in their biogas reactor. The occurrence of foaming is often related to the chemical composition of substrates fed to the reactor. The consistency of the digestate itself is also a crucial part of the foam formation process. Thus, no specific recommendations concerning substrates can be given in order to prevent foam formation in biogas plants. The safest way to avoid foaming is to test the foaming tendency of substrates on-site. A possible solution is offered by an innovative foaming test. With the help of this tool, biogas plant operators can evaluate the foaming disposition of new substrates prior to use in order to adjust the composition of substrate mixes

  9. An innovative method to anchor mandibular overdenture by OT Cap semiprecision attachment: A clinical report

    Directory of Open Access Journals (Sweden)

    Prince Kumar

    2012-01-01

    Full Text Available Since the establishment of implant in dentistry, the use of removable prostheses in replacing missing teeth apparently becomes less popular, still the preventive prosthodontics emphasizes the importance of any procedure that can delay or eliminate future prosthodontic problems. Most patients with removable partial or complete denture are dissatisfied with their retention and stability. Semiprecision attachments offer considerable advantages such as increased retention of a denture, preservation of teeth which are otherwise indicated for extraction, as a viable alternative to implant retained overdenture and the ability to obtain parallelism in divergent abutments. A prosthodontist who familiarizes himself with semiprecision attachments will be in a position to suggest a better treatment options in retaining teeth which might otherwise be considered for extraction or immediate implant placement. However, lack of proper knowledge, overwhelming number of attachments available in the market, multiple adjustments and repairs are making dentist reluctant to offer and provide attachment-retained prostheses to their patients. This case report describes an innovative technique for improving overall prognosis of mandibular overdenture using advanced and prefabricated housing attachment system.

  10. A simple method of fabricating mask-free microfluidic devices for biological analysis.

    KAUST Repository

    Yi, Xin

    2010-09-07

    We report a simple, low-cost, rapid, and mask-free method to fabricate two-dimensional (2D) and three-dimensional (3D) microfluidic chip for biological analysis researches. In this fabrication process, a laser system is used to cut through paper to form intricate patterns and differently configured channels for specific purposes. Bonded with cyanoacrylate-based resin, the prepared paper sheet is sandwiched between glass slides (hydrophilic) or polymer-based plates (hydrophobic) to obtain a multilayer structure. In order to examine the chip\\'s biocompatibility and applicability, protein concentration was measured while DNA capillary electrophoresis was carried out, and both of them show positive results. With the utilization of direct laser cutting and one-step gas-sacrificing techniques, the whole fabrication processes for complicated 2D and 3D microfluidic devices are shorten into several minutes which make it a good alternative of poly(dimethylsiloxane) microfluidic chips used in biological analysis researches.

  11. Investigative strategy for research on biological basis of traditional Chinese medicine syndrome: feature selection-based data mining methods

    Directory of Open Access Journals (Sweden)

    Jian-xin Chen

    2010-08-01

    Full Text Available This paper is devoted to discussing two research patterns of biological basis of traditional Chinese medicine syndrome and presenting a research strategy for data mining methods. It points out that data mining methods which are based on feature selection are better fit for investigating biological basis of traditional Chinese medicine syndrome. Based on such a discussion, the concept of “characteristic pattern” is proposed to bridge the gap between “golden index” and biological basis of traditional Chinese medicine syndrome. This paper presents a novel research avenue for investigating biological basis of traditional Chinese medicine syndrome.

  12. Method for assessing the impact of emission gasses on physiology and productivity in biological methanogenesis.

    Science.gov (United States)

    Seifert, A H; Rittmann, S; Bernacchi, S; Herwig, C

    2013-05-01

    This contribution presents a method for quantification of the impact of emission gasses on the methane production with hydrogenotrophic methanogenic archaea. The developed method allows a robust quantification of the influence of real gasses on the volumetric productivity of methanogenic cultures by uncoupling physiological and mass transfer effects. This is achieved over reference experiments with pure H2 and CO2, simulating the mass transfer influence of the non-convertible side components by addition of N2 to the reactant stream. Furthermore, this method was used to examine the performance of Methanothermobacter marburgensis on different emission gasses. None of the present side components had a negative effect on the volumetric methane production rate. The presented method showed to be ready to use as a generic tool for feasibility studies and quantification of the physiological impact regarding the use of exhaust gasses as reactant gas for the biological methanogenesis. PMID:23582218

  13. Assessing isocyanate exposures in polyurethane industry sectors using biological and air monitoring methods.

    Science.gov (United States)

    Creely, K S; Hughson, G W; Cocker, J; Jones, K

    2006-08-01

    ) creatinine). A total of 23 samples collected were above the agreed biological monitoring guidance value of 1.0 micromol mol(-1) creatinine. Activities that resulted in the highest biological monitoring results of the dataset included mixing and casting of polyurethane products (12.64 micromol mol(-1) creatinine), semi-automatic moulding (4.80 micromol mol(-1) creatinine) and resin application (3.91 micromol mol(-1) creatinine). The biological monitoring results show that despite low airborne isocyanate concentrations, it was possible to demonstrate biological uptake. This tends to suggest high sensitivity of the biological monitoring method and/or that in some instances the RPE being used by operators was not effective or that absorption may have occurred via dermal or other routes of exposure. This study demonstrates that biological monitoring is a useful tool when assessing worker exposure to isocyanates, providing a more complete picture on the efficacy of control measures in place than is possible by air monitoring alone. The results also demonstrated that where control measures were judged to be adequate, most biological samples were close to or < 1 micromol mol(-1) creatinine, the agreed biological monitoring benchmark. PMID:16731584

  14. Application of feature based method in constructing innovative sheathing of railway wagons

    Directory of Open Access Journals (Sweden)

    A. Baier

    2012-06-01

    Full Text Available Purpose: The aim of this work is to present the use of composite materials in the construction of freight cars. Particular attention was paid to the use of these materials in the construction of a freight wagon door. It is dangerous when mechanical damage is made to wall panels of a wagon during transport. Improperly distributed transported material can exceed the allowable stress level and thereby damage the lining of the wagon. One possible solution to this problem is replacing steel plates with composite panels which have better mechanical properties and do not cause an increase of the nominal weight of a freight wagon.Design/methodology/approach: Experimental studies included: develop a research methodology of experimental tests of deformation of the wall door of a freight wagon. using strain gauge, placing strain gauges at key points, performed single-layer and double layer laminate panels with steel plates.Findings: Composite materials made of 5 mm steel plate and a multilayer laminated panels can be used in the construction of freight cars.Research limitations/implications: An expanded scope of the studies would include an analysis and synthesis of composite panels of various thicknesses, depending on the degree of damage to the hull of a freight wagon.Practical implications: Composite panels can be applied in the repair and construction of freight wagon shells. The obtained result shows the possibility of reducing the weight of the whole railway carriage and the price of a wagon repair, eliminating the need to completely remove the shell.Originality/value: Innovative use of composite panels in the repair and construction of structural elements of freight wagons, is new to the Polish scale. Initially DB Schenker Poland, is development of interest in further research and implementation of new technology.

  15. Marketing Innovations in Croatia

    Directory of Open Access Journals (Sweden)

    Ljiljana Božić

    2011-06-01

    Full Text Available The purpose of this paper is to analyze the introduction of marketing innovations by companies in Croatia. This study provides an insight into the innovativeness with regard to the introduction of marketing innovations. It explores the presence of marketing innovations in general and the introduction of four types of marketing innovation (significant changes to the aesthetic design or packaging, new media or techniques for product promotion, new methods for product placement or sales channels and new methods of pricing goods or services. The changes in all four elements of the marketing mix are described. The paper also explores the extent to which the introduction of marketing innovation is related to the companies that introduce other types of innovations.

  16. Biologically Based Methods for Control of Fumonisin-Producing Fusarium Species and Reduction of the Fumonisins

    Science.gov (United States)

    Alberts, Johanna F.; van Zyl, Willem H.; Gelderblom, Wentzel C. A.

    2016-01-01

    Infection by the fumonisin-producing Fusarium spp. and subsequent fumonisin contamination of maize adversely affect international trade and economy with deleterious effects on human and animal health. In developed countries high standards of the major food suppliers and retailers are upheld and regulatory controls deter the importation and local marketing of fumonisin-contaminated food products. In developing countries regulatory measures are either lacking or poorly enforced, due to food insecurity, resulting in an increased mycotoxin exposure. The lack and poor accessibility of effective and environmentally safe control methods have led to an increased interest in practical and biological alternatives to reduce fumonisin intake. These include the application of natural resources, including plants, microbial cultures, genetic material thereof, or clay minerals pre- and post-harvest. Pre-harvest approaches include breeding for resistant maize cultivars, introduction of biocontrol microorganisms, application of phenolic plant extracts, and expression of antifungal proteins and fumonisin degrading enzymes in transgenic maize cultivars. Post-harvest approaches include the removal of fumonisins by natural clay adsorbents and enzymatic degradation of fumonisins through decarboxylation and deamination by recombinant carboxylesterase and aminotransferase enzymes. Although, the knowledge base on biological control methods has expanded, only a limited number of authorized decontamination products and methods are commercially available. As many studies detailed the use of natural compounds in vitro, concepts in reducing fumonisin contamination should be developed further for application in planta and in the field pre-harvest, post-harvest, and during storage and food-processing. In developed countries an integrated approach, involving good agricultural management practices, hazard analysis and critical control point (HACCP) production, and storage management, together with

  17. Biologically Based Methods for Control of Fumonisin-Producing Fusarium Species and Reduction of the Fumonisins.

    Science.gov (United States)

    Alberts, Johanna F; van Zyl, Willem H; Gelderblom, Wentzel C A

    2016-01-01

    Infection by the fumonisin-producing Fusarium spp. and subsequent fumonisin contamination of maize adversely affect international trade and economy with deleterious effects on human and animal health. In developed countries high standards of the major food suppliers and retailers are upheld and regulatory controls deter the importation and local marketing of fumonisin-contaminated food products. In developing countries regulatory measures are either lacking or poorly enforced, due to food insecurity, resulting in an increased mycotoxin exposure. The lack and poor accessibility of effective and environmentally safe control methods have led to an increased interest in practical and biological alternatives to reduce fumonisin intake. These include the application of natural resources, including plants, microbial cultures, genetic material thereof, or clay minerals pre- and post-harvest. Pre-harvest approaches include breeding for resistant maize cultivars, introduction of biocontrol microorganisms, application of phenolic plant extracts, and expression of antifungal proteins and fumonisin degrading enzymes in transgenic maize cultivars. Post-harvest approaches include the removal of fumonisins by natural clay adsorbents and enzymatic degradation of fumonisins through decarboxylation and deamination by recombinant carboxylesterase and aminotransferase enzymes. Although, the knowledge base on biological control methods has expanded, only a limited number of authorized decontamination products and methods are commercially available. As many studies detailed the use of natural compounds in vitro, concepts in reducing fumonisin contamination should be developed further for application in planta and in the field pre-harvest, post-harvest, and during storage and food-processing. In developed countries an integrated approach, involving good agricultural management practices, hazard analysis and critical control point (HACCP) production, and storage management, together with

  18. Biologically Based Methods for Control of Fumonisin-producing Fusarium species and Reduction of the Fumonisins

    Directory of Open Access Journals (Sweden)

    Johanna Francina Alberts

    2016-04-01

    Full Text Available Infection by the fumonisin-producing Fusarium spp. and subsequent fumonisin contamination of maize adversely affect international trade and economy with deleterious effects on human and animal health. In developed countries high standards of the major food suppliers and retailers are upheld and regulatory controls deter the importation and local marketing of fumonisin-contaminated food products. In developing countries regulatory measures are either lacking or poorly enforced, due to food insecurity, resulting in an increased mycotoxin exposure. The lack and poor accessibility of effective and environmentally safe control methods have led to an increased interest in practical and biological alternatives to reduce fumonisin intake. These include the application of natural resources, including plants, microbial cultures, genetic material thereof or clay minerals pre- and postharvest. Pre-harvest approaches include breeding for resistant maize cultivars, introduction of biocontrol microorganisms, application of phenolic plant extracts, and expression of antifungal proteins and fumonisin degrading enzymes in transgenic maize cultivars. Postharvest approaches include the removal of fumonisins by natural clay adsorbents and enzymatic degradation of fumonisins through decarboxylation and deamination by recombinant carboxylesterase and aminotransferase enzymes. Although the knowledge base on biological control methods has expanded, only a limited number of authorized decontamination products and methods are commercially available. As many studies detailed the use of natural compounds in vitro, concepts in reducing fumonisin contamination should be developed further for application in planta and in the field pre-harvest, postharvest, and during storage and food-processing. In developed countries an integrated approach, involving good agricultural management practices, hazard analysis and critical control point (HACCP production and storage management

  19. An innovative method for water resources carrying capacity research--Metabolic theory of regional water resources.

    Science.gov (United States)

    Ren, Chongfeng; Guo, Ping; Li, Mo; Li, Ruihuan

    2016-02-01

    The shortage and uneven spatial and temporal distribution of water resources has seriously restricted the sustainable development of regional society and economy. In this study, a metabolic theory for regional water resources was proposed by introducing the biological metabolism concept into the carrying capacity of regional water resources. In the organic metabolic process of water resources, the socio-economic system consumes water resources, while products, services and pollutants, etc. are output. Furthermore, an evaluation index system which takes into the characteristics of the regional water resources, the socio-economic system and the sustainable development principle was established based on the proposed theory. The theory was then applied to a case study to prove its availability. Further, suggestions aiming at improving the regional water carrying capacity were given on the basis of a comprehensive analysis of the current water resources situation. PMID:26683766

  20. Estimation of the Biological Methods of Assessing Soil N-Supplying Capacity in Calcareous Soil

    Institute of Scientific and Technical Information of China (English)

    JIN Fa-hui; LI Shi-qing; LU Hong-ling; LI Sheng-xiu

    2007-01-01

    Although many biological methods are used to determine soil nitrogen supplying capacity, there are certain differences in the results for different types of soils and various ways of measurement due to the complexity of soil N conformation, the high variance of soil and microorganism, and the difference of environment. Therefore, it is not clear about which biologic incubation method is better for calcareous soil. In this study, pot experiments were performed by using 25 different calcareous surface soil samples on the Loess Plateau and taking the N uptake of wheat and corn with leaching soil initial nitrate and without leaching in pot experiments as the control to investigate the difference of eight biological incubation methods for reflecting soil nitrogen supply capacity. The eight biological methods are waterlogged incubation, aerobic incubation for 2 weeks and for 4 weeks, dry-wet alternation aerobic incubation for 2 weeks, long-term alternate leaching aerobic incubation (and N mineralization potential, N0), short-term leaching aerobic incubation, microbial biomass carbon (BC), and microbial biomass nitrogen (BN) method, respectively. Among these methods, the dry-wet alternation aerobic incubation and aerobic incubation for 4 weeks were the modification of the method of aerobic incubation for 2 weeks according to the actual farmland moisture. The results showed that the correlation coefficients between these methods and crop uptake N with leaching soil initial nitrate were 0.530, 0.700, 0.777, 0.768, 0.764 (and 0.790, N0), 0.650, 0.555, and 0.465, respectively (r0.05 = 0.369, r0.01 = 0.505). While without leaching soil initial nitrate, their coefficients were 0.351, 0.963, 0.962, 0.959, 0.825 (and 0.812, N0), 0.963, 0.289, and 0.095, respectively (r0.05=0.369, r0.01 =0.505). In conclusion,excluding the soil initial nitrate, the correlation coefficients between the eight methods and crop uptake N were, from high to low, N0, aerobic incubation for 4 weeks, dry

  1. Structural characterization of low level degradants in aztreonam injection and an innovative approach to aid HPLC method validation.

    Science.gov (United States)

    Ye, Qingmei; Ding, Wei; Rinaldi, Frank; Huang, Yande; Miller, Scott A; Bolgar, Mark

    2016-05-30

    Three new degradants have been identified from drug product and active pharmaceutical ingredient stability samples of aztreonam, a marketed synthetic monocyclic beta-lactam antibiotic. The degradants were detected following the implementation of a new, more selective HPLC method for the determination of impurities and degradants. The new method was developed in response to changes in the regulatory requirement for mature products. Two of the new unknown Degradants (I and II) were observed in chromatograms from stability samples of aztreonam injection. The third new Degradant (III) was observed during a stability study of the aztreonam active pharmaceutical ingredient. These degradants were structurally characterized. A small amount (ca. 1-3mg) of each degradant was isolated via preparative HPLC for structure elucidation using accurate MS, one and two-dimensional NMR spectroscopy. The small amount of each NMR sample was then reused as a standard for HPLC purity/impurity method validation. Their exact concentrations were determined using quantitative NMR which enabled the execution of the quantitative elements of the HPLC method validation. This innovative approach eliminated the need to isolate or synthesize larger quantities of markers for HPLC/UV method validation, thus saving significant time and reducing costs. PMID:26991056

  2. 基于DEA的城市创新系统创新效率评价分析%Innovation Efficiency Evaluation Analysis of Urban Innovation Systems Based on DEA Methods

    Institute of Scientific and Technical Information of China (English)

    孙红兵; 向刚

    2011-01-01

    城市创新系统对促进城市创新活动的开展具有重要作用,对城市创新活动的创新效率进行评价具有重要现实意义.选取6个创新投入及产出的指标和30个省会城市及直辖市作为决策单元,利用DEA方法对30个城市的创新总体效率、技术效率、规模效率和饱和度作出评价,通过差额变量分析对4个非DEA有效的典型城市提出了对应的调整方案,并分地区对4种有效性进行了分析,最后提出了相应建议.%Urban innovation systems plays an important role in promoting urban innovation activity, it has an important and practical significance to evaluate the innovation efficiency of urban innovation activity. This paper selects 6 innovation input and output indexes and 30 provincial capital and municipalities as decision making units. It makes comments on overall efficiency, technical efficiency, scale efficiency and saturation of 30 cities innovation using DEA method. It puts forward corresponding adjustment scheme based on the analysis of difference variables through 4 representative urbans of the DEA ineffective, and makes detailed analysis on four effectiveness in various regions, and raises the corresponding proposal at the same time.

  3. Towards a new method for the quantification of metabolites in the biological sample

    International Nuclear Information System (INIS)

    The quantification of metabolites is a key step in drug development. The aim of this Ph.D. work was to study the feasibility of a new method for this quantification, in the biological sample, without the drawbacks (cost, time, ethics) of the classical quantification methods based on metabolites synthesis or administration to man of the radiolabelled drug. Our strategy consists in determining the response factor, in mass spectrometry, of the metabolites. This approach is based on tritium labelling of the metabolites, ex vivo, by isotopic exchange. The labelling step was studied with deuterium. Metabolites of a model drug, recovered from in vitro or urinary samples, were labelled by three ways (Crab tree's catalyst ID2, deuterated trifluoroacetic acid or rhodium chloride ID20). Then, the transposition to tritium labelling was studied and the first results are very promising for the ultimate validation of the method. (author)

  4. A numerical method for imaging of biological microstructures by VHF waves

    CERN Document Server

    Ala, Guido; Francomano, Elisa; Ganci, Salvatore

    2013-01-01

    Imaging techniques give a fundamental support to medical diagnostics during the pathology discovery as well as for the characterization of biological structures. The imaging methods involve electromagnetic waves in a frequency range that spans from some Hz to GHz and over. Most of these methods involve scanning of wide human body areas even if only small areas need to be analyzed. In this paper, a numerical method to evaluate the shape of micro-structures for application in the medical ?field, with a very low invasiveness for the human body, is proposed. A flexible thin-wire antenna radiates the VHF waves and then, by measuring the spatial magnetic ?field distribution it is possible to reconstruct the micro-structures image by estimating the location of the antenna against a sensors panel. The typical inverse problem described above is solved numerically, and ?first simulation results are presented in order to show the validity and the robustness of the proposed approach.

  5. Methods of automated cell analysis and their application in radiation biology

    International Nuclear Information System (INIS)

    The present review is concerned with the methods of automated analysis of biological microobjects and covers two groups into which all the systems of automated analysis can be divided-systems of flow ( flow cytometry) and scanning (image analysis systems) type. Particular emphasis has been placed on their use in radiobiological studies, namely, in the micronucleus test, a cytogenetic assay for monitoring the clastogenic action of ionizing radiation commonly used at present. Examples of suing methods described and actual setups in other biomedical researches are given. Analysis of advantages and disadvantages of the methods of automated cell analysis enables to choose more thoroughly between the systems of flow and scanning type to use them in particular research

  6. EVALUATION OF THE CARBON FOOTPRINT OF AN INNOVATIVE SEWER REHABILITATION METHOD

    Science.gov (United States)

    A benefit of trenchless methods touted by many practitioners when compared to open cut construction is lower carbon dioxide emissions. In an attempt to verify these claims, tools have been developed that calculate the environmental impact of traditional open cut methods and commo...

  7. EVALUATION OF THE CARBON FOOTPRINT OF AN INNOVATIVE SEWER REHABILITATION METHOD - abstract

    Science.gov (United States)

    A benefit of trenchless methods touted by many practitioners when compared to open cut construction is lower carbon dioxide emissions. In an attempt to verify these claims, tools have been developed that calculate the environmental impact of traditional open cut methods and commo...

  8. A Zinc Fusion Method for the Determination of Tritium in Biological Material by Gas Counting

    International Nuclear Information System (INIS)

    The conversion of organic compounds to a mixture of hydrogen and methane by mixture with metallic zinc and suitable catalysts offers a convenient means for the determination of tritium in organic material by gas assay. It has been found, however, that, at least in proportional counting, compounds of certain types do not give reliable results with this method; and when a trial of its application to animal tissues was made, the results were extremely inaccurate. As the principle seemed to offer several advantages over other published methods, a search was conducted for reagents which would render it usable with biological material. It was found that, when up to 10 mg of animal tissue, such as blood, muscle and liver, containing or mixed with various tritiated compounds were heated for 3 hours at 650oC in an evacuated and sealed tube of special glass together with sufficient amounts of metallic zinc powder, nickel oxide and anhydrous sodium carbonate, gas which could be assayed in brass cathode proportional counters filled to atmospheric pressure with inactive methane was produced. Above 4000 V the counters filled with this gas mixture exhibited plateaux several hundred volts long and with a slope less than 1% per 100 V. This method for conversion of biological material to a suitable gas for proportional counting was found to be readily reproducible with a mean accuracy of within better than 3%. No serious memory effects have been noted, even with samples of rather high specific activity. (author)

  9. Quality-control method for the determination of biological activity of engineered calcineurin subunit B.

    Science.gov (United States)

    Shi, Xinchang; Yang, Huan; Xu, Li; Li, Xiang; Huang, Zongwen; Han, Yudong; Wei, Qun; Rao, Chunming

    2016-06-01

    The aim of this study was to establish a quality-control method for calcineurin subunit B (CNB) biological activity determinations. CNB enhances the p-nitrophenylphosphate (pNPP) dephosphorylating activity of calcineurin subunit A Δ316 mutant (CNAΔ316). A series of CNB concentrations were fitted to a four-parameter equation to calculate the corresponding pNPP maximum dephosphorylation rates. Values were calculated based on biological activity references using a parallel line method. The method was then validated for accuracy, precision, linearity, linear range, sensitivity, specificity, and robustness. The recovery results were greater than 98%. Intra-plate precision was 6.7%, with inter-plate precision of 10.8%. The coefficient of determination was greater than 0.98. The linear range was 0.05-50 μg mL(-1), with sensitivity of 50 μg mL(-1). Tested cytokines did not induce CNAΔ316 dephosphorylation of pNPP. The chosen CNAΔ316 concentration range did not affect activity determinations. PMID:27053126

  10. Multi-energy method of digital radiography for imaging of biological objects

    Science.gov (United States)

    Ryzhikov, V. D.; Naydenov, S. V.; Opolonin, O. D.; Volkov, V. G.; Smith, C. F.

    2016-03-01

    This work has been dedicated to the search for a new possibility to use multi-energy digital radiography (MER) for medical applications. Our work has included both theoretical and experimental investigations of 2-energy (2E) and 3- energy (3D) radiography for imaging the structure of biological objects. Using special simulation methods and digital analysis based on the X-ray interaction energy dependence for each element of importance to medical applications in the X-ray range of energy up to 150 keV, we have implemented a quasi-linear approximation for the energy dependence of the X-ray linear mass absorption coefficient μm (E) that permits us to determine the intrinsic structure of the biological objects. Our measurements utilize multiple X-ray tube voltages (50, 100, and 150 kV) with Al and Cu filters of different thicknesses to achieve 3-energy X-ray examination of objects. By doing so, we are able to achieve significantly improved imaging quality of the structure of the subject biological objects. To reconstruct and visualize the final images, we use both two-dimensional (2D) and three-dimensional (3D) palettes of identification. The result is a 2E and/or 3E representation of the object with color coding of each pixel according to the data outputs. Following the experimental measurements and post-processing, we produce a 3D image of the biological object - in the case of our trials, fragments or parts of chicken and turkey.

  11. Multielemental NAA of biological, environmental and geological SRMs using k0 - method

    International Nuclear Information System (INIS)

    Instrumental Neutron Activation Analysis (INAA) using k0 - method has been employed for the determination of up to 18 elements (As, Ba, Br, Cl, Cr, Co, Cs, Dy, Fe, Hf, Ga, In, La, Mn, Na, Rb, Sc and Th) in three environmental and one geological standard reference materials (SRMs) using short and long duration irradiations. Besides, one biological standard (Bown's Kale) was also analysed for 5 elements (Br, Cl, K, Mn, and Na) by short irradiation only. Elemental data obtained for all the SRMs were in good agreement with the certified/literature values. (author)

  12. Laser method of biological activity stimulation of cryoconserved hemopoietic tissue transplant

    Science.gov (United States)

    Khyznyak, Anatoly I.; Lesnik, Svetlana A.; Kogut, Georgy I.; Glukhenkaya, Galina T.

    1994-02-01

    The biological activity of cryoconserved fetal liver cells of mice (FLM) having undergone the He-Ne laser action has been estimated by the efficiency of their transplantation to mice- recipients exposed to lethal x-ray dose. The survival rate 30 days after x-ray exposure for those mice was 75% in comparison with 70% for mice with cryoconserved nonirradiated graft. The trial animals' peripheral blood investigations have been made. The obtained results indicate that the laser method of cryoconserved cells stimulation can help to increase the therapeutic efficiency of mielotransplantation.

  13. Metrological assessment of the high-accuracy RNAA method of Co determination in biological materials

    International Nuclear Information System (INIS)

    Full text: In the contemporary world, chemical measurements are the basis for making central decisions to effective functioning of the society. The areas critically dependent on results of chemical analysis are e.g. environmental control, health, food safety, crime detection, support for R and D. Hence, there is a need for checking the reliability of the results of chemical analysis. This is of great importance especially in the case of trace analysis. One of the ways of checking the accuracy of chemical results is the use of primary methods. The aim of the presented paper has been to show that radiochemical neutron activation (RNAA) method can meet criteria for a primary ratio method (a definitive method). The high-accuracy RNAA method for the determination of trace amount of cobalt in biological materials has been developed. The method is based on a combination of neutron activation with selective and quantitative isolation of the analyte in a state of high radiochemical purity by use of column chromatography followed by gamma-ray spectrometric measurements. The method was devised according to a set of rules, which were formulated to obtain high accuracy of the method. The procedure has been also equipped with several criteria, being a key factor of quality assurance. The criteria have to be fulfilled by a result of analysis in order to be accepted. The paper summarizes the work on the development of the method and demonstrates the qualifications of the elaborated method as a primary ratio or a definitive method. The usefulness of the elaborated method in the certification of the candidate reference materials: Tea Leaves and Mixed Polish Herbs is presented. (author)

  14. Innovation af innovation

    DEFF Research Database (Denmark)

    Harste, Gorm

    2009-01-01

    , at innovation af innovationen forsøges gennemført på en måde, hvor tiden kræves at forholde sig til sin egen tidslighed i form af fremtid, nutid, fortid og ikke mindst i form af samtidighed. I tiden skal vi iagttage, hvordan vi iagttager tiden. Vi dobbelt-koder tiden på samme måde, som forskning forsker i...... organisationssystemerne. De to typer systemer kan noget helt bestemt med fænomenet tid. De kan synkronisere. Analyseres organisationssystemer ser vi, imidlertid at innovation kræver ro. Stærkt innovative systemer er militærsystemet og kunstsystemet, der også inddrages, og hvor vi ser paradokset mellem innovation og...... involution. Tid er med et medium og ikke et lufttomt rum. Tid er end ikke en gasart, men udgør et solidt fluidum, som samfundet bader i og flyder i, konstant i bevægelse. Reformer forudsætter former, og innovation forudsætter involution. Kun sådan muliggøres evolution....

  15. Open Innovation

    OpenAIRE

    Аникина, К. Ю.; Таланкина, Н. Г.

    2006-01-01

    In the past 10 years, numerous interesting articles, book chapters, and books have been written on open innovation strategies in mainly large companies. While closed innovation models have resulted in important breakthrough innovations, many large companies have abandoned vertical integration strategies in recent years and have moved toward a combination of both closed and open innovation models that are used for reaching different sets of innovative goals. The definition of open innovation a...

  16. Challenges in biomimetic design and innovation

    DEFF Research Database (Denmark)

    Lenau, Torben Anker; Barfoed, Michael; Shu, Li

    is a key issue in design and innovation work where problem identification and systematic search for suitable solution principle are major activities. One way to deal with this challenge is to use a biology search method. The use of such a method is illustrated with a case story describing the design...... including the terminology and knowledge organisation. It is often easy to recognise the splendour of a biological solution, but it can be much more difficult to understand the underlying mechanisms. Another challenge in biomimetic design is the search and identification of relevant solutions in nature. This...

  17. Innovative Columnar Type of Grid Array SJ BIST HALT Method Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Ridgetop will develop a superior method for testing and qualifying columnar type of grid arrays such as field programmable gate arrays (FPGAs) packaged in column...

  18. EVALUATION OF THE CARBON FOOTPRINT OF INNOVATIVE WATER MAIN REHABILITATION TECHNOLOGIES VS. OPEN CUT METHODS

    Science.gov (United States)

    A major benefit of trenchless rehabilitation technologies touted by many practitioners when comparing their products with tradition open cut construction methods is lower carbon dioxide (CO2) emissions. In an attempt to verify these claims, multiple tools have been dev...

  19. Using of innovative methods in physical training of students of higher educational institutions of Ukraine Ministry of Internal Affairs

    Directory of Open Access Journals (Sweden)

    Kompaniets Yu.A.

    2013-08-01

    Full Text Available It is analyzed the innovations in organization of special physical training of future law enforcement officers. It is shown those interactive methods of teaching which can be reasonably used in the process of physical training of students of higher educational institutions of Ukraine’s Ministry of Internal Affairs. It is proved that their usage is possible only after study of basic technology – the whole set of methods and actions which are defined by the normative documents of Ministry of Internal Affairs. It is shown the significance of material and technical provision and also the stages of preparation to carrying out the work in small groups, role plays, trainings. It is shown the peculiarities of usage of different interactive methods in educational process of students. It is given the scheme of conducting of role play and it is shown the main moments which should be taken into account. The usage of interactive methods in teaching assists the future law enforcement officers not only to imagine themselves in definite situation but also to receive the real psychophysiological feelings and understand the consequences from making different decisions, to get definite practical experience without real threat to their lives.

  20. Innovations in human genetics education. Alternative methods of instruction in medical genetics.

    OpenAIRE

    King, C R

    1989-01-01

    A course in medical genetics for first-year medical students was developed with the use of alternative methods of instruction, including audiovisual materials and computer-assisted instruction. The use of this methodology enabled students to consider many significant areas of medical genetics, without a dependency on the traditional lecture-based instructional format. Seventy-eight percent of the students identified the alternative instructional methods as an enhancement to their education. T...

  1. Drawer compacted sand filter: a new and innovative method for on-site grey water treatment.

    Science.gov (United States)

    Assayed, Almoayied; Chenoweth, Jonathan; Pedley, Steven

    2014-01-01

    In this paper, results ofa new sand filter design were presented. The drawer compacted sand filter (DCSF) is a modified design for a sand filter in which the sand layer is broken down into several layers, each of which is 10 cm high and placed in a movable drawer separated by a 10 cm space. A lab-scale DCSF was designed and operated for 330 days fed by synthetic grey water. The response of drawer sand filters to variable hydraulic and organic loading rates (HLR and OLR) in terms of biological oxygen demand (BODs), chemical oxygen demand (COD), total suspended solids (TSS), pH, electrical conductivity and Escherichia coli reductions were evaluated. The HLR was studied by increasing from 72 to 142 L m(-2) day(-1) and OLR was studied by increasing it from 23 to 30 g BOD5 m(-2) day(-1) while keeping the HLR constant at 142 L m(-2) day(-1). Each loading regime was applied for 110 days. Results showed that DCSF was able to remove >90% of organic matter and total suspended solids for all doses. No significant difference was noticed in terms of overall filter efficiency between different loads for all parameters. Significant reduction in BOD5 and COD (P water was drained through the third drawer in all tested loads. The paper concludes that DCSF would be appropriate for use in dense urban areas as its footprint is small and is appropriate for a wide range of users because of its convenience and low maintenance requirements. PMID:25145198

  2. Appraisal of Innovation Knowledge

    Directory of Open Access Journals (Sweden)

    Soliman Fawzy

    2014-11-01

    Full Text Available The transformation into a full fledge innovative firm requires the firms to embrace, the concept of learning organisation. Transformation should be based on the premise that the foundation of good innovation is good knowledge. Furthermore, it is widely accepted that knowledge is a key component of the concept of learning organisation. Knowledge transfer which central to the innovation chain should be based on good knowledge which has been by appropriate method for measurement of knowledge. It is shown in this paper that assessment of knowledge should result in a better management of innovation. The paper proposes that good innovation strategies are always based on good knowledge and that in order to differentiate between which knowledge is good and which is useful or applicable for innovation, then knowledge must be first evaluated or assessed using an appropriate assessment method. The paper also shows that a method for assessing the attributes of knowledge should encompass nine important characteristics of knowledge.

  3. Development of a rapid method for the automatic classification of biological agents' fluorescence spectral signatures

    Science.gov (United States)

    Carestia, Mariachiara; Pizzoferrato, Roberto; Gelfusa, Michela; Cenciarelli, Orlando; Ludovici, Gian Marco; Gabriele, Jessica; Malizia, Andrea; Murari, Andrea; Vega, Jesus; Gaudio, Pasquale

    2015-11-01

    Biosecurity and biosafety are key concerns of modern society. Although nanomaterials are improving the capacities of point detectors, standoff detection still appears to be an open issue. Laser-induced fluorescence of biological agents (BAs) has proved to be one of the most promising optical techniques to achieve early standoff detection, but its strengths and weaknesses are still to be fully investigated. In particular, different BAs tend to have similar fluorescence spectra due to the ubiquity of biological endogenous fluorophores producing a signal in the UV range, making data analysis extremely challenging. The Universal Multi Event Locator (UMEL), a general method based on support vector regression, is commonly used to identify characteristic structures in arrays of data. In the first part of this work, we investigate fluorescence emission spectra of different simulants of BAs and apply UMEL for their automatic classification. In the second part of this work, we elaborate a strategy for the application of UMEL to the discrimination of different BAs' simulants spectra. Through this strategy, it has been possible to discriminate between these BAs' simulants despite the high similarity of their fluorescence spectra. These preliminary results support the use of SVR methods to classify BAs' spectral signatures.

  4. Rapid methods to detect organic mercury and total selenium in biological samples

    Directory of Open Access Journals (Sweden)

    Basu Niladri

    2011-01-01

    Full Text Available Abstract Background Organic mercury (Hg is a global pollutant of concern and selenium is believed to afford protection against mercury risk though few approaches exist to rapidly assess both chemicals in biological samples. Here, micro-scale and rapid methods to detect organic mercury ( Results For organic Hg, samples are digested using Tris-HCl buffer (with sequential additions of protease, NaOH, cysteine, CuSO4, acidic NaBr followed by extraction with toluene and Na2S2O3. The final product is analyzed via commercially available direct/total mercury analyzers. For Se, a fluorometric assay has been developed for microplate readers that involves digestion (HNO3-HClO4 and HCl, conjugation (2,3-diaminonaphthalene, and cyclohexane extraction. Recovery of organic Hg (86-107% and Se (85-121% were determined through use of Standard Reference Materials and lemon shark kidney tissues. Conclusions The approaches outlined provide an easy, rapid, reproducible, and cost-effective platform for monitoring organic Hg and total Se in biological samples. Owing to the importance of organic Hg and Se in the pathophysiology of Hg, integration of such methods into established research monitoring efforts (that largely focus on screening total Hg only will help increase understanding of Hg's true risks.

  5. Comparison of growth methods and biological activities of brazilian marine Streptomyces

    Directory of Open Access Journals (Sweden)

    A. C. Granato

    2013-03-01

    Full Text Available The present work describes the study of the growth and the cytotoxic and antitumor activities of the extracts of the marine microorganisms Streptomyces acrymicini and Streptomyces cebimarensis, the latter a new strain. Both microorganisms were collected from coastal marine sediments of the north coast of São Paulo state. Growth was performed in a shaker and in a bioreactor using Gym medium and the broths of both microorganisms were extracted with ethyl acetate and n-butanol. Three extracts, two organic and one aqueous, from each microorganism were obtained and tested for cytotoxic and antitumor activity using the SF-295 (Central Nervous System, HCT-8 (Colon cell lines, and the MTT (3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method. The growth methods were compared and show that, although the shaker presented reasonable results, the bioreactor represents the best choice for growth of these microorganisms. The biological activity of the different extracts was evaluated and it was demonstrated that the growth methodology may influence the secondary metabolite production and the biological activity.

  6. The method of radioactive tracer for measuring the amount of inorganic nanoparticles in biological samples

    Science.gov (United States)

    Buzulukov, Yu; Antsiferova, A.; Demin, V. A.; Demin, V. F.; Kashkarov, P.

    2015-11-01

    The method to measure the mass of inorganic nanoparticles in biological (or any other samples) using nanoparticles labeled with radioactive tracers is developed and applied to practice. The tracers are produced in original nanoparticles by radioactive activation of some of their atomic nuclei. The method of radioactive tracers demonstrates a sensitivity, specificity and accuracy equal or better than popular methods of optical and mass spectrometry, or electron microscopy and has some specific advantages. The method can be used for study of absorption, distribution, metabolism and excretion in living organism, as well as in ecological and fundamental research. It was used in practice to study absorption, distribution, metabolism and excretion of nanoparticles of Ag, Au, Se, ZnO, TiO2 as well as to study transportation of silver nanoparticles through the barriers of blood-brain, placenta and milk gland of rats. Brief descriptions of data obtained in experiments with application of this method included in the article. The method was certified in Russian Federation standard system GOST-R and recommended by the Russian Federation regulation authority ROSPOTREBNADZOR for measuring of toxicokinetic and organotropy parameters of nanoparticles.

  7. A simple kinetic spectrophotometric method for the determination of oxamniquine in formulations and spiked biological fluids.

    Science.gov (United States)

    Rizk, M; Belal, F; Ibrahim, F; Ahmed, S M; El-Enany, N M

    2000-08-15

    A simple and sensitive kinetic method for the determination of oxamniquine in pharmaceutical preparations and biological fluids was developed. The procedure is based upon a kinetic investigation of the oxidation reaction of the drug with alkaline potassium permanganate at room temperature for a fixed time of 20 min. The absorbance of the colored manganate ions was measured at 610 nm. Alternatively, the decrease in the absorbance of potassium permanganate after addition of the drug was measured at 525 nm. The absorbance concentration plots in both procedures were rectilinear over the range 0.5-4 microg ml(-1). The concentration of oxamniquine is calculated using the corresponding calibration equation for the fixed-time method. The determination of oxamniquine by fixed-concentration and rate-constant methods was feasible with the calibration equations obtained but the fixed time method had been found to be more applicable. Both procedures were applied to the determination of oxamniquine in formulations. The results obtained were in good agreement with those obtained using the official method. The fixed time method of 20 min was further applied to spiked human urine and plasma, the recoveries (%) were 100.94 +/- 0.57 and 98.07 +/- 0.88 for urine and plasma, respectively, at 610 nm, and 97.51 +/- 1.27 and 95.69 +/- 1.23 for urine and plasma, respectively, at 525 nm. PMID:10933544

  8. An innovations-based method for DC-signal failure detection

    International Nuclear Information System (INIS)

    A state-space approach method for failure detection in DC-signals is described. The detection system receives data from sensors as input and estimates the DC state by means of Kalman filtering methodology, where the data assumed to be obeying a non-linear ARE model. The cumulative sum test (CUSUM) is implemented in real-time to the estimated DC state resulting from the Kalman filter as the test is in particular suitable for jump or pulse type anomalies in those signals subject to DC-level change. To test the effectiveness of the method Borssele NPP DC signals with operational changes were used. Real-time test observations showed operational effectiveness of the method. (author). 5 refs.; 5 figs

  9. Comparative description of structure and properties of Ti-6Al-4V titanium alloy for biomedical applications produced by two methods: conventional (molding) and innovative (injection) ones

    OpenAIRE

    Klimas, J; M. Szota; M. Nabiałek; A. Łukaszewicz; Bukowska, A.

    2013-01-01

    Purpose: In paper characterized two methods produced titanium alloy: hitherto used in industry – conti-casting and innovative method of obtaining solid amorphous alloy by injection casting. The results of studies comparing the structure and properties of the alloy Ti-6Al-4V produced by both methods. Design/methodology/approach: Test samples were titanium alloy Ti-6Al-4V produced by two methods: conventional and injection. To achieve the objective pursued performed the following...

  10. BIOLOGICAL MARKERS FOR SELECTION ON THE FROST RESISTANCE OF WINTER WHEAT AND BARLEY FORM

    Directory of Open Access Journals (Sweden)

    Plotnikov V. K.

    2014-12-01

    Full Text Available We have described the theoretical assumptions and methodological solutions in the present review. They are innovative possibilities in the development of laboratory methods for assessing biological features of grain during the selection process

  11. Pedagogical effectiveness of innovative teaching methods initiated at the Department of Physiology, Government Medical College, Chandigarh.

    Science.gov (United States)

    Nageswari, K Sri; Malhotra, Anita S; Kapoor, Nandini; Kaur, Gurjit

    2004-12-01

    Modern teaching trends in medical education exhibit a paradigm shift from the conventional classroom teaching methods adopted in the past to nonconventional teaching aids so as to encourage interactive forms of learning in medical students through active participation and integrative reasoning where the relationship of the teacher and the taught has undergone tremendous transformation. Some of the nonconventional teaching methods adopted at our department are learning through active participation by the students through computer-assisted learning (CD-ROMs), Web-based learning (undergraduate projects), virtual laboratories, seminars, audiovisual aids (video-based demonstrations), and "physioquiz." PMID:15149960

  12. An innovative exercise method to simulate orbital EVA work - Applications to PLSS automatic controls

    Science.gov (United States)

    Lantz, Renee; Vykukal, H.; Webbon, Bruce

    1987-01-01

    An exercise method has been proposed which may satisfy the current need for a laboratory simulation representative of muscular, cardiovascular, respiratory, and thermoregulatory responses to work during orbital extravehicular activity (EVA). The simulation incorporates arm crank ergometry with a unique body support mechanism that allows all body position stabilization forces to be reacted at the feet. By instituting this exercise method in laboratory experimentation, an advanced portable life support system (PLSS) thermoregulatory control system can be designed to more accurately reflect the specific work requirements of orbital EVA.

  13. Innovative confocal laser method for exact dioptric power measurement of intraocular lens implants Invited Paper

    Institute of Scientific and Technical Information of China (English)

    Ilko K. Ilev; Robert W. Faaland; Do-Hyun Kim; Robert H. James; Don Calogero

    2008-01-01

    We present a novel confocal laser method (CLM) for precise testing of the dioptric power of both positive and negative intraocular lens (IOL) implants. The CLM principle is based on a simple fiber-optic confocal laser design including a single-mode fiber coupler that serves simultaneously as a point light source used for formation of a collimated Gaussian laser beam, and as a highly sensitive confocal point receiver. The CLM approach provides an accurate, repeatable, objective, and fast method for IOL dioptric power measurement over the range from 0 D to greater than =t=30 D under both dry and in-situ simulated conditions.

  14. Chromosome painting and prematurely condensed chromosomes (PCC) - new methods of biological dosimetry

    International Nuclear Information System (INIS)

    Classic methods of biological dosimetry - micronucleus and dicentric assay pose several problems. In the case of micronucleus there is a wide range of spontaneous frequencies and smoking and age are powerfull contributing factors. In the case of dicentrics - low mitotic index in some individuals especially in the elderly or accidentally exposed to high radiation doses. So, there are 2 quite new molecular techniques which at least in part solve these problems: chromosome painting and PCC. Chromosome painting by employing chromosome-specific DNA probes allow easy identification and quantification of translocations. recently, it was shown that calyculin A or okadaic acid, inhibitors of 1 and 2A protein phosphatases, induce PCC in peripheral blood cells. This is an easy biodosimetric method with a high PCC index and independent of the ability of cells to divide e.g. after high (20 Gy) doses when the mitotic index is extremely low. (author)

  15. Selection of Suitable Biological Method for the Synthesis of Silver Nanoparticles

    Directory of Open Access Journals (Sweden)

    Muhammad Ashraf Sabri

    2016-04-01

    Full Text Available This paper aims to present a brief overview of different biosynthesis routes of silver nanoparticles (NPs, their applications and influence of the method used on the size and morphology of these nanoparticles. A detailed and comprehensive study of available biological methods, also referred to as a bottom-up approach, as well as techniques reported, have been provided with an eye for details and comparison between the techniques involving fungi, bacteria, algae and plant extracts. Plant-derived bioreduc‐ tants such as leaf, stem or root extracts of various plants are seen as suitable solutions to green synthesis of silver NPs, implementing an easy, non-toxic, clean and environmen‐ tally friendly approach. Furthermore, reports on the antimicrobial activities with the zone of inhibition for various pathogens have also been included.

  16. A simulation method for determining the optical response of highly complex photonic structures of biological origin

    CERN Document Server

    Dolinko, Andrés E

    2013-01-01

    We present a method based on a time domain simulation of wave propagation that allows studying the optical response of a broad range of dielectric photonic structures. This method is particularly suitable for dealing with complex biological structures. One of the main features of the proposed approach is the simple and intuitive way of defining the setup and the photonic structure to be simulated, which can be done by feeding the simulation with a digital image of the structure. We also develop a set of techniques to process the behavior of the evolving waves within the simulation. These techniques include a direction filter, that permits decoupling of waves travelling simultaneously in different directions, a dynamic differential absorber, to cancel the waves reflected at the edges of the simulation space, a multi-frequency excitation scheme based on a filter that allows decoupling waves of different wavelengths travelling simultaneously, and a near-to-far-field approach to evaluate the resulting wavefield o...

  17. Analysis of Teaching Methods Innovation of Legal Professions of Higher Vocational Education

    Directory of Open Access Journals (Sweden)

    Xu Hui

    2014-02-01

    Full Text Available With the needs of economic and social development, the legal system of China has been constantly improved. As a result, our country is in increasingly urgent demand for legal professionals. Legal professions of higher vocational colleges are responsible for the training of a variety of application-oriented legal talents for our country, which plays a very important role for the construction of the legal system. However, at present, there are some disadvantages in teaching methods of higher vocational legal professions, such as the imitation of general education while lack of vocational characteristics, the rigid and single teaching methods, and theory divorced from reality. The paper will start from these drawbacks, and will propose such appropriate solutions as the introduction of teaching method of case study, the implementation of "Clinic-style" practical teaching, and the conduction of "Law-article" teaching method, in the hope of offering some help to the development of higher vocational legal professions and cultivating truly practical legal talents with professional capacity, able to take up the mission of the law, and able to make a significant contribution to the legal system construction of the country, in cooperation with this wide range of vocational legal education models.

  18. Innovative Mixed-Methods Research: Moving beyond Design Technicalities to Epistemological and Methodological Realizations

    Science.gov (United States)

    Riazi, A. Mehdi

    2016-01-01

    Mixed-methods research (MMR), as an inter-discourse (quantitative and qualitative) methodology, can provide applied linguistics researchers the opportunity to draw on and integrate the strengths of the two research methodological approaches in favour of making more rigorous inferences about research problems. In this article, the argument is made…

  19. DriftLess™, an innovative method to estimate and compensate for the biases of inertial sensors

    NARCIS (Netherlands)

    Ruizenaar, M.G.H.; Kemp, R.A.W.

    2014-01-01

    In this paper a method is presented that allows for bias compensation of low-cost MEMS inertial sensors. It is based on the use of two sets of inertial sensors and a rotation mechanism that physically rotates the sensors in an alternating fashion. After signal processing, the biases of both sets of

  20. Efficient computational methods to study new and innovative signal detection techniques in SETI

    Science.gov (United States)

    Deans, Stanley R.

    1991-01-01

    The purpose of the research reported here is to provide a rapid computational method for computing various statistical parameters associated with overlapped Hann spectra. These results are important for the Targeted Search part of the Search for ExtraTerrestrial Intelligence (SETI) Microwave Observing Project.

  1. An innovative method for rapid identification and detection of Vibrio alginolyticus in different infection models

    Directory of Open Access Journals (Sweden)

    Kaifei eFu

    2016-05-01

    Full Text Available Vibrio alginolyticus is one of the most common pathogenic marine Vibrio species, and has been found to cause serious seafood-poisoning or fatal extra-intestinal infections in humans, such as necrotizing soft-tissue infections, bacteremia, septic shock and multiple organ failures. Delayed accurate diagnosis and treatment of most Vibrio infections usually result to high mortality rates. The objective of this study was to establish a rapid diagnostic method to detect and identify the presence of V. alginolyticus in different samples, so as to facilitate timely treatment. The widely employed conventional methods for detection of V. alginolyticus include biochemical identification and a variety of PCR methods. The former is of low specificity and time-consuming (2-3 days, while the latter has improved accuracy and processing time. Despite such advancements, these methods are still complicated, time-consuming, expensive, require expertise and advanced laboratory systems, and are not optimal for field use. With the goal of providing a simple and efficient way to detect V. alginolyticus, we established a rapid diagnostic method based on Loop-mediated Isothermal Amplification (LAMP technology that is feasible to use in both experimental and field environments. Three primer pairs targeting the toxR gene of V. alginolyticus were designed, and amplification was carried out in an ESE tube scanner and Real-Time PCR device. We successfully identified 93 V. alginolyticus strains from a total of 105 different bacterial isolates and confirmed their identity by 16s rDNA sequencing. We also applied this method on infected mouse blood and contaminated scallop samples, and accurate results were both easily and rapidly (20-60min obtained. Therefore, the RT-LAMP assay we developed can be conveniently used to detect the presence of V. alginolyticus in different samples. Furthermore, this method will also fulfill the gap for real-time screening of V. alginolyticus

  2. Studies on Microbiological and Biological Methods for Detection of Irradiated Food

    International Nuclear Information System (INIS)

    The main aim of this study is to evaluate a microbiological and biological methods used for the detection of irradiated foods in Egypt. The microbiological methods included were shift in microflora load and direct epifluroescent filter technique compared with aerobic plate count (DEFT/APC), while the biological method was DNA comet assay. The selected foods were black, strawberry, fresh-and frozen-de boned chicken. The samples of these foods were exposed to different doses of gamma radiation according to the purpose of irradiation for each food. The results indicated that the characteristics of microbial population of all irradiated samples have been changed. The very lower count of viable bacterial count (APC) and mold and yeasts counts in the samples than the reported normal count as well as the absence of Gram- negative bacteria and Enterobacteriaceae group from these samples could be used as an indication for radiation treatment of these foods. The large difference between microbial counts obtained by DEFT test and that obtained by APC test could also be used for screening radiation treatment of these foods. Photographic and image analysis of DNA comet assay showed that irradiation of these foods caused damage to the food cells DNA (fragmentation) at different levels according to the doses used and kind of foods. This DNA damage can be followed or described by DNA comet assay test. On the basis of comet assay, the discrimination between unirradiated and irradiated food samples was very possible. In general the results showed that DEFT/APC method had the potential to detect irradiated food samples either at zero time of storage or throughout the storage period post- irradiation. DNA comet assay as a rapid, simple and inexpensive screening test approved to be successful for detection of irradiated food samples under investigation. Determination of rough applied irradiation dose is possible if photographic analysis is combined with image analysis

  3. Source Allocation of Long-Range Asian Dusts Transportation across the Taiwan Strait by Innovative Chemical-Assisted Identification Methods

    Directory of Open Access Journals (Sweden)

    Yi-Hsiu Jen

    2014-01-01

    Full Text Available This study used the backward trajectory calculation to obtain the transportation routes of Asian dusts and further combined the chemical composition with the enrichment factor (EF and the grey relational analysis (GR to identify the potential sources of eighteen Asian dust storm (ADS events. The results showed that the chemical compositions of atmospheric particles sampled at the Pescadores Islands were very similar to source soils fugitively emitted from Inner Mongolia, which could assist in identifying the source regions of Asian dusts. This study further compared the source allocation of Asian dusts obtained from EF, GR, and backward trajectory, which showed that the source regions of Asian dusts obtained from these three methods were quite similar. The similarity of backward trajectory and GR reached as high as 83.3%. Moreover, the similarity of backward trajectory calculation and EF or GR was up to 77.8% while that of the GR and EF was up to 83.3%. Overall, these three methods can successfully allocate the source regions of Asian dusts by 66.7%. Moreover, these innovative chemical-assisted methods can be successfully applied to identify the source regions of Asian dusts for 18 ADS events.

  4. [A novel biological pathway expansion method based on the knowledge of protein-protein interactions].

    Science.gov (United States)

    Zhao, Xiaolei; Zuo, Xiaoyu; Qin, Jiheng; Liang, Yan; Zhang, Naizun; Luan, Yizhao; Rao, Shaoqi

    2014-04-01

    Biological pathways have been widely used in gene function studies; however, the current knowledge for biological pathways is per se incomplete and has to be further expanded. Bioinformatics prediction provides us a cheap but effective way for pathway expansion. Here, we proposed a novel method for biological pathway prediction, by intergrating prior knowledge of protein?protein interactions and Gene Ontology (GO) database. First, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to which the interacting neighbors of a targe gene (at the level of protein?protein interaction) belong were chosen as the candidate pathways. Then, the pathways to which the target gene belong were determined by testing whether the genes in the candidate pathways were enriched in the GO terms to which the target gene were annotated. The protein?protein interaction data obtained from the Human Protein Reference Database (HPRD) and Biological General Repository for Interaction Datasets (BioGRID) were respectively used to predict the pathway attribution(s) of the target gene. The results demanstrated that both the average accuracy (the ratio of the correctly predicted pathways to the totally pathways to which all the target genes were annotated) and the relative accuracy (of the genes with at least one annotated pathway being successful predicted, the percentage of the genes with all the annotated pathways being correctly predicted) for pathway predictions were increased with the number of the interacting neighbours. When the number of interacting neighbours reached 22, the average accuracy was 96.2% (HPRD) and 96.3% (BioGRID), respectively, and the relative accuracy was 93.3% (HPRD) and 84.1% (BioGRID), respectively. Further validation analysis of 89 genes whose pathway knowledge was updated in a new database release indicated that 50 genes were correctly predicted for at least one updated pathway, and 43 genes were accurately predicted for all the updated pathways, giving an

  5. Isotopic tracer method in the investigation of the scraper work in the clarifier of the biological sewage-treatment plant

    International Nuclear Information System (INIS)

    A method of investigation of the velocity of sediment transport in a clarifier of the biological sewage- treatment plant is described. It is based on the tracking of the motion of sediment portion containing 32P or 140La. (author)

  6. Numerical simulation of nanopulse penetration of biological matter using the ADI-FDTD method

    Science.gov (United States)

    Zhu, Fei

    Nanopulses are ultra-wide-band (UWB) electromagnetic pulses with pulse duration of only a few nanoseconds and electric field amplitudes greater than 105 V/m. They have been widely used in the development of new technologies in the field of medicine. Therefore, the study of the nanopulse bioeffects is important to ensure the appropriate application with nanopulses in biomedical and biotechnological settings. The conventional finite-difference time-domain (FDTD) method for solving Maxwell's equations has been proven to be an effective method to solve the problems related to electromagnetism. However, its application is restricted by the Courant, Friedrichs, and Lewy (CFL) stability condition that confines the time increment and mesh size in the computation in order to prevent the solution from being divergent. This dissertation develops a new finite difference scheme coupled with the Cole-Cole expression for dielectric coefficients of biological tissues to simulate the electromagnetic fields inside biological tissues when exposed to nanopulses. The scheme is formulated based on the Yee's cell and alternating direction implicit (ADI) technique. The basic idea behind the ADI technique is to break up every time step into two half-time steps. At the first half-step, the finite difference operator on the right-hand side of the Maxwell's equation is implicit only along one coordinate axis direction. At the second half-step, the finite difference operator on the right-hand side of the Maxwell's equation is implicit only along the other coordinate axis direction. As such, only tridiagonal linear systems are solved. In this numerical method, the Cole-Cole expression is approximated by a second-order Taylor series based on the z-transform method. In addition, the perfectly matched layer is employed for the boundary condition, and the total/scattered field technique is employed to generate the plane wave in order to prevent the wave reflection. The scheme is tested by numerical

  7. Radiofrequency Kyphoplasty - An Innovative Method of Treating Osteoporotic Vertebral Body Compression Fractures

    Directory of Open Access Journals (Sweden)

    Drees P

    2011-01-01

    Full Text Available Osteoporotic vertebral body fractures are encountered increasingly often. Cement augmentation using vertebroplasty or balloon kyphoplasty are standardised and established procedures. However, the optimal cement viscosity at the time of cement augmentation has not yet been satisfactory resolved for either method. In other words, the time point of cement application is left to the surgeon’s subjective estimation. Early application of cement may cause cement leakage whereas late application may cause incomplete filling of the vertebral body. Radiofrequency kyphoplasty is a recently developed augmentation system that enables the surgeon to exert control when creating the cavity, as well as aids him in the placement and application of cement. Cement is applied by remote control and thus uniformly retains its properties. The method is presented in the following.

  8. Analysis of Teaching Methods Innovation of Legal Professions of Higher Vocational Education

    OpenAIRE

    Xu Hui; Yinghua Wan; Xiaoxia Feng

    2014-01-01

    With the needs of economic and social development, the legal system of China has been constantly improved. As a result, our country is in increasingly urgent demand for legal professionals. Legal professions of higher vocational colleges are responsible for the training of a variety of application-oriented legal talents for our country, which plays a very important role for the construction of the legal system. However, at present, there are some disadvantages in teaching methods of higher vo...

  9. An Innovator Nonintrusive Method for Disaggregating and Identifying Two Simultaneous Household Loads

    OpenAIRE

    Pérez-Romero, Máximo; Romero-Cadaval, Enrique; Lozano-Tello, Adolfo; Martins, João; Lopes, Rui

    2014-01-01

    At the present time the monitoring systems are important in some areas, such as electric power supply industry and household environment because they provide useful information to energy storage and management tasks. A new nonintrusive monitoring method is proposed in this paper and it is able to disaggregate and identify two loads working simultaneously using a single measuring sensor and a least squares regression algorithm based on discrete form of the S-Transform.

  10. Crowdsourcing, Open Innovation and Collective Intelligence in the scientific method: a research agenda and operational framework

    OpenAIRE

    Bücheler, T; Füchslin, R M; Pfeifer, R.; Sieg, J H

    2010-01-01

    The lonely researcher trying to crack a problem in her office still plays an important role in fundamental research. However, a vast exchange, often with participants from different fields is taking place in modern research activities and projects. In the "Research Value Chain" (a simplified depiction of the Scientific Method as a process used for the analyses in this paper), interactions between researchers and other individuals (intentional or not) within or outside their respective institu...

  11. The two coupling fluids method for ultrasonic velocity measurement. Application to biological tissues

    International Nuclear Information System (INIS)

    Measuring the ultrasonic velocity in soft materials, especially in biological tissues, is never easy. One of the main issues is that the thickness of the sample under test is badly defined. From the time-of-flight measurement method, uncertainties in the thickness induce important uncertainties in experimental results. This implies that the ultrasonic velocity is often a poor criterion when it could be a good one. This paper introduces a new method to measure the ultrasonic velocity in soft materials without knowing the sample thickness The main idea of this method is to use two different coupling media to make two relative time-of-flight measurements. The comparison of these two measurements gives the ultrasonic velocity in the sample under test. Furthermore, this comparison can give the local thickness of the sample. The uncertainty calculations show that the effect on the thickness is drastically reduced by using this new ultrasound method. This method is validated on a reference sample (silicone). Before conclusion, some experimental results obtained with mouse skin samples are presented

  12. Evaluation of radiochemical neutron activation analysis methods for determination of arsenic in biological materials.

    Science.gov (United States)

    Paul, Rick L

    2011-01-01

    Radiochemical neutron activation analysis (RNAA) with retention on hydrated manganese dioxide (HMD) has played a key role in the certification of As in biological materials at NIST. Although this method provides very high and reproducible yields and detection limits at low microgram/kilogram levels, counting geometry uncertainties may arise from unequal distribution of As in the HMD, and arsenic detection limits may not be optimal due to significant retention of other elements. An alternate RNAA procedure with separation of arsenic by solvent extraction has been investigated. After digestion of samples in nitric and perchloric acids, As(III) is extracted from 2 M sulfuric acid solution into a solution of zinc diethyldithiocarbamate in chloroform. Counting of (76)As allows quantitation of arsenic. Addition of an (77)As tracer solution prior to dissolution allows correction for chemical yield and counting geometries, further improving reproducibility. The HMD and solvent extraction procedures for arsenic were compared through analysis of SRMs 1577c (bovine liver), 1547 (peach leaves), and 1575a (pine needles). Both methods gave As results in agreement with certified values with comparable reproducibility. However, the solvent extraction method yields a factor of 3 improvement in detection limits and is less time-consuming than the HMD method. The new method shows great promise for use in As certification in reference materials. PMID:21133431

  13. A comparative analysis on computational methods for fitting an ERGM to biological network data

    Directory of Open Access Journals (Sweden)

    Sudipta Saha

    2015-03-01

    Full Text Available Exponential random graph models (ERGM based on graph theory are useful in studying global biological network structure using its local properties. However, computational methods for fitting such models are sensitive to the type, structure and the number of the local features of a network under study. In this paper, we compared computational methods for fitting an ERGM with local features of different types and structures. Two commonly used methods, such as the Markov Chain Monte Carlo Maximum Likelihood Estimation and the Maximum Pseudo Likelihood Estimation are considered for estimating the coefficients of network attributes. We compared the estimates of observed network to our random simulated network using both methods under ERGM. The motivation was to ascertain the extent to which an observed network would deviate from a randomly simulated network if the physical numbers of attributes were approximately same. Cut-off points of some common attributes of interest for different order of nodes were determined through simulations. We implemented our method to a known regulatory network database of Escherichia coli (E. coli.

  14. A novel cell weighing method based on the minimum immobilization pressure for biological applications

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Qili [Robotics and Mechatronics Research Laboratory, Department of Mechanical and Aerospace Engineering, Monash University, Clayton 3800 (Australia); Institute of Robotics and Automatic Information System, Nankai University, Tianjin 300071 (China); Shirinzadeh, Bijan [Robotics and Mechatronics Research Laboratory, Department of Mechanical and Aerospace Engineering, Monash University, Clayton 3800 (Australia); Cui, Maosheng [Biotechnology Lab of Animal Reproduction, Tianjin Animal Sciences, Tianjin 300112 (China); Sun, Mingzhu; Liu, Yaowei; Zhao, Xin, E-mail: zhaoxin@nankai.edu.cn [Institute of Robotics and Automatic Information System, Nankai University, Tianjin 300071 (China)

    2015-07-28

    A novel weighing method for cells with spherical and other regular shapes is proposed in this paper. In this method, the relationship between the cell mass and the minimum aspiration pressure to immobilize the cell (referred to as minimum immobilization pressure) is derived for the first time according to static theory. Based on this relationship, a robotic cell weighing process is established using a traditional micro-injection system. Experimental results on porcine oocytes demonstrate that the proposed method is able to weigh cells at an average speed of 16.3 s/cell and with a success rate of more than 90%. The derived cell mass and density are in accordance with those reported in other published results. The experimental results also demonstrated that this method is able to detect less than 1% variation of the porcine oocyte mass quantitatively. It can be conducted by a pair of traditional micropipettes and a commercial pneumatic micro-injection system, and is expected to perform robotic operation on batch cells. At present, the minimum resolution of the proposed method for measuring the cell mass can be 1.25 × 10{sup −15 }kg. Above advantages make it very appropriate for quantifying the amount of the materials injected into or moved out of the cells in the biological applications, such as nuclear enucleations and embryo microinjections.

  15. A novel cell weighing method based on the minimum immobilization pressure for biological applications

    International Nuclear Information System (INIS)

    A novel weighing method for cells with spherical and other regular shapes is proposed in this paper. In this method, the relationship between the cell mass and the minimum aspiration pressure to immobilize the cell (referred to as minimum immobilization pressure) is derived for the first time according to static theory. Based on this relationship, a robotic cell weighing process is established using a traditional micro-injection system. Experimental results on porcine oocytes demonstrate that the proposed method is able to weigh cells at an average speed of 16.3 s/cell and with a success rate of more than 90%. The derived cell mass and density are in accordance with those reported in other published results. The experimental results also demonstrated that this method is able to detect less than 1% variation of the porcine oocyte mass quantitatively. It can be conducted by a pair of traditional micropipettes and a commercial pneumatic micro-injection system, and is expected to perform robotic operation on batch cells. At present, the minimum resolution of the proposed method for measuring the cell mass can be 1.25 × 10−15 kg. Above advantages make it very appropriate for quantifying the amount of the materials injected into or moved out of the cells in the biological applications, such as nuclear enucleations and embryo microinjections

  16. Investigation of trend analysis of monthly total precipitation by an innovative method

    Science.gov (United States)

    Ay, Murat; Kisi, Ozgur

    2015-05-01

    The purpose of this study is to detect possible trend in monthly total precipitation rate on the basis of Mann-Kendall (MK) and a new method recently proposed by Şen trend tests. The new method is used for trend analysis of monthly total precipitation data recorded at Samsun, Trabzon, Ankara, Yozgat, Adana, and Antalya provinces in Turkey. For comparison purposes, the well-known MK trend test is also applied to the same data. According to the MK trend test, Samsun and Trabzon generally have statistically significant increasing trend. There is no statistically significant trend (trendless time series) for Ankara, Yozgat, and Adana provinces. While the February month of Antalya shows statistically significant decreasing trend, April month of Antalya shows statistically significant increasing trend. According to the Şen's trend test, peak and low values of monthly total precipitation of the six provinces show different trends (increasing, decreasing, or trendless time series) from the MK trend test. The study shows that the Şen method could be successfully used in evaluation of peak and low values of data for trend analysis of monthly total precipitation variable.

  17. Mindful innovation

    DEFF Research Database (Denmark)

    Olsen, Poul Bitsch

    2008-01-01

    Mindful innovation is an approach to innovation that pays attention to people's experience in an organization rather than to formal organization or social role.......Mindful innovation is an approach to innovation that pays attention to people's experience in an organization rather than to formal organization or social role....

  18. Innovative didaktik

    DEFF Research Database (Denmark)

    Lund, Birthe

    Innovative didaktik. This deals with innovative didaktik from at methodological point of view in three ways - how to define the concept, how to develop it and how analyse it. Issues analysed: How to create innovative students? How to create innovative learning envoriments? These are core questions...

  19. Innovative application of mathematical methods in evaluation of ore raw materials for production of iron

    Directory of Open Access Journals (Sweden)

    P. Besta

    2014-01-01

    Full Text Available Current principles of evaluation of ore raw materials are usually based on a comparison of selected isolated criteria. Today‘s sophisticated technological level of blast furnace process requires the introduction of raw material indicators that provide global characteristics of their quality. This can´t be realized with isolated parameters only. The evaluation should incorporate the key characteristics of iron ore and convert them into a uniform evaluation parameter. This article analyzes the use of mathematical methods in the evaluation of the quality of ore raw materials.

  20. A direct solid sampling analysis method for the detection of silver nanoparticles in biological matrices.

    Science.gov (United States)

    Feichtmeier, Nadine S; Ruchter, Nadine; Zimmermann, Sonja; Sures, Bernd; Leopold, Kerstin

    2016-01-01

    Engineered silver nanoparticles (AgNPs) are implemented in food contact materials due to their powerful antimicrobial properties and so may enter the human food chain. Hence, it is desirable to develop easy, sensitive and fast analytical screening methods for the determination of AgNPs in complex biological matrices. This study describes such a method using solid sampling high-resolution continuum source graphite furnace atomic absorption spectrometry (GFAAS). A recently reported novel evaluation strategy uses the atomization delay of the respective GFAAS signal as significant indicator for AgNPs and thereby allows discrimination of AgNPs from ionic silver (Ag(+)) in the samples without elaborate sample pre-treatment. This approach was further developed and applied to a variety of biological samples. Its suitability was approved by investigation of eight different food samples (parsley, apple, pepper, cheese, onion, pasta, maize meal and wheat flour) spiked with ionic silver or AgNPs. Furthermore, the migration of AgNPs from silver-impregnated polypropylene food storage boxes to fresh pepper was observed and a mussel sample obtained from a laboratory exposure study with silver was investigated. The differences in the atomization delays (Δt(ad)) between silver ions and 20-nm AgNPs vary in a range from -2.01 ± 1.38 s for maize meal to +2.06 ± 1.08 s for mussel tissue. However, the differences were significant in all investigated matrices and so indicative of the presence/absence of AgNPs. Moreover, investigation of model matrices (cellulose, gelatine and water) gives the first indication of matrix-dependent trends. Reproducibility and homogeneity tests confirm the applicability of the method. PMID:26483187

  1. Longwall mining “cutting cantilever beam theory” and 110 mining method in China—The third mining science innovation

    Directory of Open Access Journals (Sweden)

    Manchao He

    2015-10-01

    Full Text Available With the third innovation in science and technology worldwide, China has also experienced this marvelous progress. Concerning the longwall mining in China, the “masonry beam theory” (MBT was first proposed in the 1960s, illustrating that the transmission and equilibrium method of overburden pressure using reserved coal pillar in mined-out areas can be realized. This forms the so-called “121 mining method”, which lays a solid foundation for development of mining science and technology in China. The “transfer rock beam theory” (TRBT proposed in the 1980s gives a further understanding for the transmission path of stope overburden pressure and pressure distribution in high-stress areas. In this regard, the advanced 121 mining method was proposed with smaller coal pillar for excavation design, making significant contributions to improvement of the coal recovery rate in that era. In the 21st century, the traditional mining technologies faced great challenges and, under the theoretical developments pioneered by Profs. Minggao Qian and Zhenqi Song, the “cutting cantilever beam theory” (CCBT was proposed in 2008. After that the 110 mining method is formulated subsequently, namely one stope face, after the first mining cycle, needs one advanced gateway excavation, while the other one is automatically formed during the last mining cycle without coal pillars left in the mining area. This method can be implemented using the CCBT by incorporating the key technologies, including the directional pre-splitting roof cutting, constant resistance and large deformation (CRLD bolt/anchor supporting system with negative Poisson's ratio (NPR effect material, and remote real-time monitoring technology. The CCBT and 110 mining method will provide the theoretical and technical basis for the development of mining industry in China.

  2. Longwall mining“cutting cantilever beam theory”and 110 mining method in ChinadThe third mining science innovation

    Institute of Scientific and Technical Information of China (English)

    Manchao He; Guolong Zhu; Zhibiao Guo

    2015-01-01

    abstract With the third innovation in science and technology worldwide, China has also experienced this marvelous progress. Concerning the longwall mining in China, the “masonry beam theory” (MBT) was first proposed in the 1960s, illustrating that the transmission and equilibrium method of overburden pressure using reserved coal pillar in mined-out areas can be realized. This forms the so-called “121 mining method”, which lays a solid foundation for development of mining science and technology in China. The“transfer rock beam theory”(TRBT) proposed in the 1980s gives a further understanding for the transmission path of stope overburden pressure and pressure distribution in high-stress areas. In this regard, the advanced 121 mining method was proposed with smaller coal pillar for excavation design, making significant contributions to improvement of the coal recovery rate in that era. In the 21st century, the traditional mining technologies faced great challenges and, under the theoretical developments pioneered by Profs. Minggao Qian and Zhenqi Song, the “cutting cantilever beam theory” (CCBT) was proposed in 2008. After that the 110 mining method is formulated subsequently, namely one stope face, after the first mining cycle, needs one advanced gateway excavation, while the other one is automatically formed during the last mining cycle without coal pillars left in the mining area. This method can be implemented using the CCBT by incorporating the key technologies, including the directional pre-splitting roof cutting, constant resistance and large deformation (CRLD) bolt/anchor supporting system with negative Poisson’s ratio (NPR) effect material, and remote real-time monitoring technology. The CCBT and 110 mining method will provide the theoretical and technical basis for the development of mining industry in China.

  3. LASER METHODS IN BIOLOGY: Optical anisotropy of fibrous biological tissues: analysis of the influence of structural properties

    Science.gov (United States)

    Zimnyakov, D. A.; Sinichkin, Yu P.; Ushakova, O. V.

    2007-08-01

    The results of theoretical analysis of the optical anisotropy of multiply scattering fibrillar biological tissues based on the model of an effective anisotropic medium are compared with the experimental in vivo birefringence data for the rat derma obtained earlier in spectral polarisation measurements of rat skin samples in the visible region. The disordered system of parallel dielectric cylinders embedded into an isotropic dielectric medium was considered as a model medium. Simulations were performed taking into account the influence of a partial mutual disordering of the bundles of collagen and elastin fibres in derma on birefringence in samples. The theoretical optical anisotropy averaged over the spectral interval 550-650 nm for the model medium with parameters corresponding to the structural parameters of derma is in good agreement with the results of spectral polarisation measurements of skin samples in the corresponding wavelength range.

  4. Investigation of an innovative method for DC flow suppression of double-inlet pulse tube coolers

    Science.gov (United States)

    Hu, J. Y.; Luo, E. C.; Wu, Z. H.; Dai, W.; Zhu, S. L.

    2007-05-01

    The use of double-inlet mode in the pulse tube cooler opens up a possibility of DC flow circulating around the regenerator and the pulse tube. The DC flow sometimes deteriorates the performance of the cryocooler because such a steady flow adds an unwanted thermal load to the cold heat exchanger. It seems that this problem is still not well solved although a lot of effort has been made. Here we introduce a membrane-barrier method for DC flow suppression in double-inlet pulse tube coolers. An elastic membrane is installed between the pulse tube cooler inlet and the double-inlet valve to break the closed-loop flow path of DC flow. The membrane is acoustically transparent, but would block the DC flow completely. Thus the DC flow is thoroughly suppressed and the merit of double-inlet mode is remained. With this method, a temperature reduction of tens of Kelvin was obtained in our single-stage pulse tube cooler and the lowest temperature reached 29.8 K.

  5. An Innovative Passive Tip-Leakage Control Method for Axial Turbines: Basic Concept and Performance Potential

    Institute of Scientific and Technical Information of China (English)

    Markus Hamik; Reinhard Willinger

    2007-01-01

    The present paper introduces a new concept for passive turbine tip-leakage control. The basic idea of the method is the connection of the blade leading edge and the blade tip by an internal channel. Due to the difference between the stagnation pressure at the leading edge and the low pressure at the blade tip, a small amount of the working fluid is extracted from the blade passage. At the blade tip, a jet is injected roughly perpendicular to the tip gap flow driven by the blade pressure difference. It is proposed that the jet blocks at least a part of the tip gap flow.Since the tip-leakage losses are proportional to the tip gap mass flow rate, the tip injection results in a reduction of the associated losses. After the introduction of the concept, an analytical model is presented which describes the reduction of the tip gap discharge coefficient due to the tip injection. Furthermore, the analytical model is supported by the results of a preliminary CFD analysis. Finally, the potential of the efficiency improvement by the passive blade tip injection method is reported.

  6. Innovative separation method for advanced spent fuel reprocessing based on tertiary pyridine resin

    International Nuclear Information System (INIS)

    Radiochemical separation experiments have been performed in order to realize a novel reprocessing method based on chromatography techniques using a novel pyridine resin. The newly synthesized tertiary pyridine resin with two functions of ion exchanger and soft-donor was dedicated to the experiments, where highly irradiated mixed oxide fuel from the experimental fast reactor JOYO was used as a reference spent fuel. With a 3-step separation, pure Am and Cm were individually obtained as minor actinide products, and 106Ru group, lanthanides with 137Cs group and Pu group were fractionated, respectively. The decontamination factor of 137Cs and trivalent lanthanides (155Eu, 144Ce) against the Am product exceeded 3.9 x 104 and 1.0 x 105, respectively. The decontamination factor as the mutual separation of 243Cm was larger than 2.2 x 103 against the Am product. Moreover, the content of 137Cs, trivalent lanthanides and 243Cm in Am product did not exceed 2 ppm. The tertiary pyridine resin method is a candidate separation system for an 'advanced ORIENT process', where enhanced separation, transmutation and utilization of actinides, long-lived fission products and rare metal fission product would be oriented. (author)

  7. Methods of technical and tactical training basketball players with hearing impairments using innovative technologies

    Directory of Open Access Journals (Sweden)

    Kozina Zh.L

    2014-06-01

    Full Text Available Purpose: to develop information technology for technical and tactical training of skilled basketball players with hearing impairments. Material : the study involved 24 women's national team athletes Ukrainian Basketball hearing impaired (age - 25-30 years. Technical protocols were processed 12 games from the World Cup and Europe, XXII Summer Deaflympics. Fixed number of shots and hit free throws, steals, rebounds and on its offensive rebounds, fouls and errors. Results : the developed system of tactical training basketball players with hearing impairments. Accentuation was made of the prevalence of method visibility while developing tactical interactions. The main result was the development of the author's method of video tutorials with animated illustrations. Also, use the lamp LS Line-3-65-12-C to control the training process athletes. Conclusions : there was a significant improvement in competitive activity athletes. Athletes performed significantly more hits from the foul line and successful shots from long range compared to main rivals. Also increased the number of interceptions in games. Application of information technology had an impact on the competitive result: basketball team of Ukraine took the second place in the Deaflympics in Sofia in 2013.

  8. A few nascent methods for measuring mechanical properties of the biological cell.

    Energy Technology Data Exchange (ETDEWEB)

    Thayer, Gayle Echo; de Boer, Maarten Pieter; Corvalan, Carlos (Purdue University, West Lafayette, IN); Corwin, Alex David; Campanella, Osvaldo H. (Purdue University, West Lafayette, IN); Nivens, David (Purdue University, West Lafayette, IN); Werely, Steven (Purdue University, West Lafayette, IN); Sumali, Anton Hartono; Koch, Steven John

    2006-01-01

    This report summarizes a survey of several new methods for obtaining mechanical and rheological properties of single biological cells, in particular: (1) The use of laser Doppler vibrometry (LDV) to measure the natural vibrations of certain cells. (2) The development of a novel micro-electro-mechanical system (MEMS) for obtaining high-resolution force-displacement curves. (3) The use of the atomic force microscope (AFM) for cell imaging. (4) The adaptation of a novel squeezing-flow technique to micro-scale measurement. The LDV technique was used to investigate the recent finding reported by others that the membranes of certain biological cells vibrate naturally, and that the vibration can be detected clearly with recent instrumentation. The LDV has been reported to detect motions of certain biological cells indirectly through the motion of a probe. In this project, trials on Saccharomyces cerevisiae tested and rejected the hypothesis that the LDV could measure vibrations of the cell membranes directly. The MEMS investigated in the second technique is a polysilicon surface-micromachined force sensor that is able to measure forces to a few pN in both air and water. The simple device consists of compliant springs with force constants as low as 0.3 milliN/m and Moire patterns for nanometer-scale optical displacement measurement. Fields from an electromagnet created forces on magnetic micro beads glued to the force sensors. These forces were measured and agreed well with finite element prediction. It was demonstrated that the force sensor was fully functional when immersed in aqueous buffer. These results show the force sensors can be useful for calibrating magnetic forces on magnetic beads and also for direct measurement of biophysical forces on-chip. The use of atomic force microscopy (AFM) for profiling the geometry of red blood cells was the third technique investigated here. An important finding was that the method commonly used for attaching the cells to a

  9. Integration of biological method and membrane technology in treating palm oil mill effluent

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yejian; YAN Li; QIAO Xiangli; CHI Lina; NIU Xiangjun; MEI Zhijian; ZHANG Zhenjia

    2008-01-01

    Palm oil industry is the most important agro-industry in Malaysia, but its by-product-palm oil mill effluent (POME), posed a great threat to water environment. In the past decades, several treatment and disposal methods have been proposed and investigated to solve this problem. A two-stage pilot-scale plant was designed and constructed for POME treatment. Anaerobic digestion and aerobic biodegradation constituted the first biological stage, while ultrafiltration (UF) and reverse osmosis (RO) membrane units were combined as the second membrane separation stage. In the anaerobic expanded granular sludge bed (EGSB) reactor, about 43% organic matter in POME was converted into biogas, and COD reduction efficiency reached 93% and 22% in EGSB and the following aerobic reactor, respectively. With the treatment in the first biological stage, suspended solids and oil also decreased to a low degree. All these alleviated the membrane fouling and prolonged the membrane life. In the membrane process unit, almost all the suspended solids were captured by UF membranes, while RO membrane excluded most of the dissolved solids or inorganic salts from RO permeate. After the whole treatment processes, organic matter in POME expressed by BOD and COD was removed almost thoroughly. Suspended solids and color were not detectable in RO permeate any more, and mineral elements only existed in trace amount (except for K and Na). The high-quality effluent was crystal clear and could be used as the boiler feed water.

  10. Computational biology in the cloud: methods and new insights from computing at scale.

    Science.gov (United States)

    Kasson, Peter M

    2013-01-01

    The past few years have seen both explosions in the size of biological data sets and the proliferation of new, highly flexible on-demand computing capabilities. The sheer amount of information available from genomic and metagenomic sequencing, high-throughput proteomics, experimental and simulation datasets on molecular structure and dynamics affords an opportunity for greatly expanded insight, but it creates new challenges of scale for computation, storage, and interpretation of petascale data. Cloud computing resources have the potential to help solve these problems by offering a utility model of computing and storage: near-unlimited capacity, the ability to burst usage, and cheap and flexible payment models. Effective use of cloud computing on large biological datasets requires dealing with non-trivial problems of scale and robustness, since performance-limiting factors can change substantially when a dataset grows by a factor of 10,000 or more. New computing paradigms are thus often needed. The use of cloud platforms also creates new opportunities to share data, reduce duplication, and to provide easy reproducibility by making the datasets and computational methods easily available. PMID:23424149

  11. Structural identifiability of systems biology models: a critical comparison of methods.

    Directory of Open Access Journals (Sweden)

    Oana-Teodora Chis

    Full Text Available Analysing the properties of a biological system through in silico experimentation requires a satisfactory mathematical representation of the system including accurate values of the model parameters. Fortunately, modern experimental techniques allow obtaining time-series data of appropriate quality which may then be used to estimate unknown parameters. However, in many cases, a subset of those parameters may not be uniquely estimated, independently of the experimental data available or the numerical techniques used for estimation. This lack of identifiability is related to the structure of the model, i.e. the system dynamics plus the observation function. Despite the interest in knowing a priori whether there is any chance of uniquely estimating all model unknown parameters, the structural identifiability analysis for general non-linear dynamic models is still an open question. There is no method amenable to every model, thus at some point we have to face the selection of one of the possibilities. This work presents a critical comparison of the currently available techniques. To this end, we perform the structural identifiability analysis of a collection of biological models. The results reveal that the generating series approach, in combination with identifiability tableaus, offers the most advantageous compromise among range of applicability, computational complexity and information provided.

  12. 3D printing method for freeform fabrication of optical phantoms simulating heterogeneous biological tissue

    Science.gov (United States)

    Wang, Minjie; Shen, Shuwei; Yang, Jie; Dong, Erbao; Xu, Ronald

    2014-03-01

    The performance of biomedical optical imaging devices heavily relies on appropriate calibration. However, many of existing calibration phantoms for biomedical optical devices are based on homogenous materials without considering the multi-layer heterogeneous structures observed in biological tissue. Using such a phantom for optical calibration may result in measurement bias. To overcome this problem, we propose a 3D printing method for freeform fabrication of tissue simulating phantoms with multilayer heterogeneous structure. The phantom simulates not only the morphologic characteristics of biological tissue but also absorption and scattering properties. The printing system is based on a 3D motion platform with coordinated control of the DC motors. A special jet nozzle is designed to mix base, scattering, and absorption materials at different ratios. 3D tissue structures are fabricated through layer-by-layer printing with selective deposition of phantom materials of different ingredients. Different mixed ratios of base, scattering and absorption materials have been tested in order to optimize the printing outcome. A spectrometer and a tissue spectrophotometer are used for characterizing phantom absorption and scattering properties. The goal of this project is to fabricate skin tissue simulating phantoms as a traceable standard for the calibration of biomedical optical spectral devices.

  13. Integration of biological method and membrane technology in treating palm oil mill effluent.

    Science.gov (United States)

    Zhang, Yejian; Yan, Li; Qiao, Xiangli; Chi, Lina; Niu, Xiangjun; Mei, Zhijian; Zhang, Zhenjia

    2008-01-01

    Palm oil industry is the most important agro-industry in Malaysia, but its by-product-palm oil mill effluent (POME), posed a great threat to water environment. In the past decades, several treatment and disposal methods have been proposed and investigated to solve this problem. A two-stage pilot-scale plant was designed and constructed for POME treatment. Anaerobic digestion and aerobic biodegradation constituted the first biological stage, while ultrafiltration (UF) and reverse osmosis (RO) membrane units were combined as the second membrane separation stage. In the anaerobic expanded granular sludge bed (EGSB) reactor, about 43% organic matter in POME was converted into biogas, and COD reduction efficiency reached 93% and 22% in EGSB and the following aerobic reactor, respectively. With the treatment in the first biological stage, suspended solids and oil also decreased to a low degree. All these alleviated the membrane fouling and prolonged the membrane life. In the membrane process unit, almost all the suspended solids were captured by UF membranes, while RO membrane excluded most of the dissolved solids or inorganic salts from RO permeate. After the whole treatment processes, organic matter in POME expressed by BOD and COD was removed almost thoroughly. Suspended solids and color were not detectable in RO permeate any more, and mineral elements only existed in trace amount (except for K and Na). The high-quality effluent was crystal clear and could be used as the boiler feed water. PMID:18575108

  14. Evaluation of analytical methods for fluorine in biological and related materials.

    Science.gov (United States)

    Venkateswarlu, P

    1990-02-01

    During the past two decades, some major pitfalls in fluorine analysis have been recognized and overcome. Therefore, it is important that facts be separated from fallacies in published literature on levels and forms of fluorine (ionic, bound, covalent, etc.) in biological materials, in order that correct perceptions of physiological, biochemical, and toxicological aspects of inorganic as well as organic fluorine compounds can be formed. Trace amounts of inorganic fluoride in biological samples can now be accurately determined with the fluoride electrode either directly or following diffusion, adsorption, or reverse extraction of fluoride (when necessary). The aluminum monofluoride molecular absorption technique provides an excellent rapid method for determination of trace amounts of inorganic fluoride (in the absence of organic fluorine). Fluorine in most organic fluorine compounds is not available for distillation, diffusion, or reverse-extraction. The sample needs to be ashed (open ashing) or combusted (oxygen flask, oxygen bomb, pyrohydrolysis) for covalently bound fluorine to be converted to fluoride ions. This can now be readily accomplished at room temperature by the reductive cleavage of the C-F bond with the sodium biphenyl reagent. Some recommendations for future research have been made. PMID:2179310

  15. Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis.

    Science.gov (United States)

    Ivanescu, Bianca; Miron, Anca; Corciova, Andreia

    2015-01-01

    Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of Asteraceae family, with over 5000 structures reported to date. Within this family, genus Artemisia is very well represented, having approximately 500 species characterized by the presence of eudesmanolides and guaianolides, especially highly oxygenated ones, and rarely of germacranolides. Sesquiterpene lactones exhibit a wide range of biological activities, such as antitumor, anti-inflammatory, analgesic, antiulcer, antibacterial, antifungal, antiviral, antiparasitic, and insect deterrent. Many of the biological activities are attributed to the α-methylene-γ-lactone group in their molecule which reacts through a Michael-addition with free sulfhydryl or amino groups in proteins and alkylates them. Due to the fact that most sesquiterpene lactones are thermolabile, less volatile compounds, they present no specific chromophores in the molecule and are sensitive to acidic and basic mediums, and their identification and quantification represent a difficult task for the analyst. Another problematic aspect is represented by the complexity of vegetal samples, which may contain compounds that can interfere with the analysis. Therefore, this paper proposes an overview of the methods used for the identification and quantification of sesquiterpene lactones found in Artemisia genus, as well as the optimal conditions for their extraction and separation. PMID:26495156

  16. Service Innovation Consulting:Evaluation of Methods Employed%服务创新顾问案中所采用的顾问方法整理与评估

    Institute of Scientific and Technical Information of China (English)

    林俊毅; 曹承礎

    2009-01-01

    Many consulting firms and research institutions have started providing consultancy services for service innovations.However,academic research has not kept pace with rapidly changing developments in consulting businesses.This study evaluated all known methods currently used in service innovation consulting,and analyzed the actual practices of service innovation consulting to clarify trends in service innovation.Methods are evaluated by their strategy orientation and divergence orientation,and then classified according to a proposed general service innovation consulting framework.The findings of this study indicate that the current focus of service innovation consulting is:customer needs discovery.However.an integrated service innovation methodology covering customer needs discovery,market discovery,idea generation,strategy formulation,service engineering,and simulation/pilot is urgently needed.

  17. Data Mining – Innovative Method for Obtaining Information in Marketingand Business Management

    Directory of Open Access Journals (Sweden)

    Mirela-Cristina Voicu

    2011-05-01

    Full Text Available The existence of massive amounts of data raised the question of using their reorientation to a retrospective to a prospective operation. Data mining offers the promise of an important aid for discovering hidden patterns in data that can be used to predict the behavior of customers, products and processes. Data mining tools must be guided by users who understand the business, the general nature of the data and analytical methods involved. It discovers information within the data that queries and reports can’t effectively reveal. It is vital to collect data and prepare properly, to face reality models. Choosing the most appropriate product data mining is to find a tool with the capabilities required, an interface that matches the skills of users and can be applied in a specific business problem. In this context, the purpose of this paper is to illustrate some of the problems of company activity problems which can be solved by using data mining techniques.

  18. Contracting process innovation

    OpenAIRE

    Nissen, Mark E.

    2001-01-01

    Process innovation pertains to making dramatic improvements in performance of enterprise processes. Stemming from total quality management, business process reengineering and other widely-accepted approaches to performance improvement in the business enterprise, process innovation has largely been practiced without a systematic method and required expertise only possessed by a few, highly-talented people. Now, as the result of research in this area, the process of process innovation now has a...

  19. Appraisal of Innovation Knowledge

    OpenAIRE

    Soliman Fawzy

    2014-01-01

    The transformation into a full fledge innovative firm requires the firms to embrace, the concept of learning organisation. Transformation should be based on the premise that the foundation of good innovation is good knowledge. Furthermore, it is widely accepted that knowledge is a key component of the concept of learning organisation. Knowledge transfer which central to the innovation chain should be based on good knowledge which has been by appropriate method for measurement of knowledge. It...

  20. Innovate to Survive

    OpenAIRE

    WEGNEZ, Leon F.

    2014-01-01

    Innovation is a social process capable of creating the conditions for business success, being centrally important for business competitiveness, but it needs to be properly managed by combining a supportive culture and an integrated process in order to create a sustainable competitive advantage. Innovation is an ongoing, multifaceted challenge involving a constant questioning of our policies, our strategies, our methods, our individual actions. It affects the future. Research, innovation and d...

  1. INNOVATE TO SURVIVE

    OpenAIRE

    F WEGNEZ, Leon

    2014-01-01

    Innovation is a social process capable of creating the conditions for business success, being centrally important for business competitiveness, but it needs to be properly managed by combining a supportive culture and an integrated process in order to create a sustainable competitive advantage. Innovation is an ongoing, multifaceted challenge involving a constant questioning of our policies, our strategies, our methods, our individual actions. It affects the future. Research, innovation and d...

  2. Teaching Biology through Statistics: Application of Statistical Methods in Genetics and Zoology Courses

    OpenAIRE

    Colon-Berlingeri, Migdalisel; Burrowes, Patricia A.

    2011-01-01

    Incorporation of mathematics into biology curricula is critical to underscore for undergraduate students the relevance of mathematics to most fields of biology and the usefulness of developing quantitative process skills demanded in modern biology. At our institution, we have made significant changes to better integrate mathematics into the undergraduate biology curriculum. The curricular revision included changes in the suggested course sequence, addition of statistics and precalculus as pre...

  3. Improved method and apparatus for electrostatically sorting biological cells. [DOE patent application

    Science.gov (United States)

    Merrill, J.T.

    An improved method of sorting biological cells in a conventional cell sorter apparatus includes generating a fluid jet containing cells to be sorted, measuring the distance between the centers of adjacent droplets in a zone thereof defined at the point where the fluid jet separates into descrete droplets, setting the distance between the center of a droplet in said separation zone and the position along said fluid jet at which the cell is optically sensed for specific characteristics to be an integral multiple of said center-to-center distance, and disabling a charger from electrically charging a specific droplet if a cell is detected by the optical sensor in a position wherein it will be in the neck area between droplets during droplet formation rather than within a predetermined distance from the droplet center.

  4. New derivation method and simulation of skin effect in biological tissue.

    Science.gov (United States)

    Fan, Xiaoli; Zhou, Qianxiang; Liu, Zhongqi; Xie, Fang

    2015-01-01

    Based on the electrical properties of biological tissues, bioimpedance measurement technology can be employed to collect physiologic and pathologic information by measuring changes in human bioimpedance. When an alternating current (AC) is applied as a detection signal to a tissue, the current field distribution, which is affected by skin effect, is related to both the bioimpedance of the tissue and the AC frequency. These relations would possibly reduce the accuracy and reliability of the measurement. In this study, an electromagnetic theory-based method, in which cylindrical conductor were divided into layers, was used to obtain current field distribution models of human limbs. Model simulations were conducted in MATLAB. The skin effect phenomenon and its characteristics in human tissues at different frequencies were observed, thus providing essential data on skin effect, which are useful in the development of bioimpedance measurement technology. PMID:26406033

  5. Study of Relaxation by Traditional Medicinal Methods on Biological Indexes of the Elderly (Abstract)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@The objective of the study was to prove the relaxation effect of traditional medicine by objective biological indexes by modern scientific methods. Fifty healthy elderly people, aged from 60 to 75, were selected to have traditional medicinal relaxing practice, that is, to relax their body in 3 directions: two sides, in front and backward, and breath naturally, 30 minutes a day, 8 weeks as a cycle. (1) The changes of electroencephalogram (EEG), rheoencephalogram (REG) were measured before and after the treatment cycle. Breath frequency and SaO2 contents were measured before and after the treatment cycle by Pulse oxymeter. (2) As for the circulatory system, pulse frequency, blood pressure, blood influx of limbs were measured before and after the treatment cycle. (3) Biochemical indexes (including index of cholesterol, triglyceride, blood sugar, cortisone, catecholamine) were measured before and after the treatment cycle.

  6. Study of Relaxation by Traditional Medicinal Methods on Biological Indexes of the Elderly (Abstract)

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The objective of the study was to prove the relaxation effect of traditional medicine by objective biological indexes by modern scientific methods.  Fifty healthy elderly people, aged from 60 to 75, were selected to have traditional medicinal relaxing practice, that is, to relax their body in 3 directions: two sides, in front and backward, and breath naturally, 30 minutes a day, 8 weeks as a cycle. (1) The changes of electroencephalogram (EEG), rheoencephalogram (REG) were measured before and after the treatment cycle. Breath frequency and SaO2 contents were measured before and after the treatment cycle by Pulse oxymeter. (2) As for the circulatory system, pulse frequency, blood pressure, blood influx of limbs were measured before and after the treatment cycle. (3) Biochemical indexes (including index of cholesterol, triglyceride, blood sugar, cortisone, catecholamine) were measured before and after the treatment cycle.……

  7. Innovative method for recovery and valorization of hydroxytyrosol from olive mill wastewaters.

    Science.gov (United States)

    Bonetti, A; Venturini, S; Ena, A; Faraloni, C

    2016-01-01

    The nutritional properties of olive oil can be attributed to its oleic acid and phenolic compounds content, acting as natural oxidants to prevent human diseases. In particular, hydroxytyrosol has an anti-inflammatory action similar to omega 3 fatty acids from fish oil. The olive oil production was conducted by two extraction procedures: first, a two-phase extraction giving extra-virgin olive oil and humid pomace, second, a three-phase working process of humid pomace, obtaining another minimum quantity of extra-virgin olive oil, 'dry' pomace devoid of polyphenols, and mill wastewaters rich in anti-oxidant compounds. The aim of this processing was to employ water to extract the highest concentration of polyphenols from humid pomace and convey them in oil mill wastewaters for extraction. Processed olives were 37,200 kg, pomace deprived of polyphenols was equal to 20,400 kg and processing was performed with 500 kg of olives per hour. This method offers advantages of using cheap equipment and technical simplicity. PMID:27386985

  8. Characterization of chlorinated solvent contamination in limestone using innovative FLUTe® technologies in combination with other methods in a line of evidence approach

    DEFF Research Database (Denmark)

    Broholm, Mette Martina; Janniche, Gry Sander; Mosthaf, Klaus;

    2016-01-01

    Characterization of dense non-aqueous phase liquid (DNAPL) source zones in limestone aquifers/bedrock is essential to develop accurate site-specific conceptual models and perform risk assessment. Here innovative field methods were combined to improve determination of source zone architecture...

  9. Data Mining Methods for Omics and Knowledge of Crude Medicinal Plants toward Big Data Biology

    Directory of Open Access Journals (Sweden)

    Farit M. Afendi

    2013-01-01

    Full Text Available Molecular biological data has rapidly increased with the recent progress of the Omics fields, e.g., genomics, transcriptomics, proteomics and metabolomics that necessitates the development of databases and methods for efficient storage, retrieval, integration and analysis of massive data. The present study reviews the usage of KNApSAcK Family DB in metabolomics and related area, discusses several statistical methods for handling multivariate data and shows their application on Indonesian blended herbal medicines (Jamu as a case study. Exploration using Biplot reveals many plants are rarely utilized while some plants are highly utilized toward specific efficacy. Furthermore, the ingredients of Jamu formulas are modeled using Partial Least Squares Discriminant Analysis (PLS-DA in order to predict their efficacy. The plants used in each Jamu medicine served as the predictors, whereas the efficacy of each Jamu provided the responses. This model produces 71.6% correct classification in predicting efficacy. Permutation test then is used to determine plants that serve as main ingredients in Jamu formula by evaluating the significance of the PLS-DA coefficients. Next, in order to explain the role of plants that serve as main ingredients in Jamu medicines, information of pharmacological activity of the plants is added to the predictor block. Then N-PLS-DA model, multiway version of PLS-DA, is utilized to handle the three-dimensional array of the predictor block. The resulting N-PLS-DA model reveals that the effects of some pharmacological activities are specific for certain efficacy and the other activities are diverse toward many efficacies. Mathematical modeling introduced in the present study can be utilized in global analysis of big data targeting to reveal the underlying biology.

  10. Teaching Biology through Statistics: Application of Statistical Methods in Genetics and Zoology Courses

    Science.gov (United States)

    Colon-Berlingeri, Migdalisel; Burrowes, Patricia A.

    2011-01-01

    Incorporation of mathematics into biology curricula is critical to underscore for undergraduate students the relevance of mathematics to most fields of biology and the usefulness of developing quantitative process skills demanded in modern biology. At our institution, we have made significant changes to better integrate mathematics into the…

  11. Innovative methods for the design of miniatured state of the art neutronic channels for future FBR

    International Nuclear Information System (INIS)

    Neutron flux in fast reactor varies over 10 decades from shutdown to full power. This is monitored in all states of the reactor by Neutron flux monitoring systems. The system consists of several sets of detectors and instrument channels. For smooth transition from one set of instrument channel to other, interlocks with auto inhibition in safety logic are provided. In the present reactor, Fission counters are placed in control plug under vessel. The signals from these detectors are connected to preamplifiers near to the sensors. The signals from these preamplifiers are again connected to instrument channels in control building local control centres, which generate parameters such as logarithmic power, period, linear power and reactivity signals. Interlocks with auto inhibition are provided in safety logic for smooth transition from one detector-channel to other. With this arrangement, difficulties are faced such as, two sets of detectors are required at two different locations. Three different types of instrument channels are required. In each channel, there is a trade-off between response time and accuracy. Many interlocks with auto inhibitions are to be provided for transition from one system to another. Volume of electronics involved is very high. The pulses are also not periodical. Hence counting techniques do not result in accurate prediction of frequency and intern power. Either the accuracy of counting or the counting time has to be sacrificed. It can also be seen that as the frequency goes up the pulses over lap. Hence estimating the power using pulse counting can't predict the power correctly. In the Campbell method, which is used in the intermediate range also there is a trade-off between the accuracy and response time and linearity could be seen only for 3 decades. Hence the new approach viz. PCA (principle component analysis) is discussed in this paper. PCA is non-parametric method of extracting relevant information from mixed data by reducing a complex

  12. Evaluation of hierarchical agglomerative cluster analysis methods for discrimination of primary biological aerosol

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2015-07-01

    Full Text Available In this paper we present improved methods for discriminating and quantifying Primary Biological Aerosol Particles (PBAP by applying hierarchical agglomerative cluster analysis to multi-parameter ultra violet-light induced fluorescence (UV-LIF spectrometer data. The methods employed in this study can be applied to data sets in excess of 1×106 points on a desktop computer, allowing for each fluorescent particle in a dataset to be explicitly clustered. This reduces the potential for misattribution found in subsampling and comparative attribution methods used in previous approaches, improving our capacity to discriminate and quantify PBAP meta-classes. We evaluate the performance of several hierarchical agglomerative cluster analysis linkages and data normalisation methods using laboratory samples of known particle types and an ambient dataset. Fluorescent and non-fluorescent polystyrene latex spheres were sampled with a Wideband Integrated Bioaerosol Spectrometer (WIBS-4 where the optical size, asymmetry factor and fluorescent measurements were used as inputs to the analysis package. It was found that the Ward linkage with z-score or range normalisation performed best, correctly attributing 98 and 98.1 % of the data points respectively. The best performing methods were applied to the BEACHON-RoMBAS ambient dataset where it was found that the z-score and range normalisation methods yield similar results with each method producing clusters representative of fungal spores and bacterial aerosol, consistent with previous results. The z-score result was compared to clusters generated with previous approaches (WIBS AnalysiS Program, WASP where we observe that the subsampling and comparative attribution method employed by WASP results in the overestimation of the fungal spore concentration by a factor of 1.5 and the underestimation of bacterial aerosol concentration by a factor of 5. We suggest that this likely due to errors arising from misatrribution

  13. Evaluation of hierarchical agglomerative cluster analysis methods for discrimination of primary biological aerosol

    Directory of Open Access Journals (Sweden)

    I. Crawford

    2015-11-01

    Full Text Available In this paper we present improved methods for discriminating and quantifying primary biological aerosol particles (PBAPs by applying hierarchical agglomerative cluster analysis to multi-parameter ultraviolet-light-induced fluorescence (UV-LIF spectrometer data. The methods employed in this study can be applied to data sets in excess of 1 × 106 points on a desktop computer, allowing for each fluorescent particle in a data set to be explicitly clustered. This reduces the potential for misattribution found in subsampling and comparative attribution methods used in previous approaches, improving our capacity to discriminate and quantify PBAP meta-classes. We evaluate the performance of several hierarchical agglomerative cluster analysis linkages and data normalisation methods using laboratory samples of known particle types and an ambient data set. Fluorescent and non-fluorescent polystyrene latex spheres were sampled with a Wideband Integrated Bioaerosol Spectrometer (WIBS-4 where the optical size, asymmetry factor and fluorescent measurements were used as inputs to the analysis package. It was found that the Ward linkage with z-score or range normalisation performed best, correctly attributing 98 and 98.1 % of the data points respectively. The best-performing methods were applied to the BEACHON-RoMBAS (Bio–hydro–atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen–Rocky Mountain Biogenic Aerosol Study ambient data set, where it was found that the z-score and range normalisation methods yield similar results, with each method producing clusters representative of fungal spores and bacterial aerosol, consistent with previous results. The z-score result was compared to clusters generated with previous approaches (WIBS AnalysiS Program, WASP where we observe that the subsampling and comparative attribution method employed by WASP results in the overestimation of the fungal spore concentration by a factor of 1.5 and the

  14. Evaluation of hierarchical agglomerative cluster analysis methods for discrimination of primary biological aerosol

    Science.gov (United States)

    Crawford, I.; Ruske, S.; Topping, D. O.; Gallagher, M. W.

    2015-11-01

    In this paper we present improved methods for discriminating and quantifying primary biological aerosol particles (PBAPs) by applying hierarchical agglomerative cluster analysis to multi-parameter ultraviolet-light-induced fluorescence (UV-LIF) spectrometer data. The methods employed in this study can be applied to data sets in excess of 1 × 106 points on a desktop computer, allowing for each fluorescent particle in a data set to be explicitly clustered. This reduces the potential for misattribution found in subsampling and comparative attribution methods used in previous approaches, improving our capacity to discriminate and quantify PBAP meta-classes. We evaluate the performance of several hierarchical agglomerative cluster analysis linkages and data normalisation methods using laboratory samples of known particle types and an ambient data set. Fluorescent and non-fluorescent polystyrene latex spheres were sampled with a Wideband Integrated Bioaerosol Spectrometer (WIBS-4) where the optical size, asymmetry factor and fluorescent measurements were used as inputs to the analysis package. It was found that the Ward linkage with z-score or range normalisation performed best, correctly attributing 98 and 98.1 % of the data points respectively. The best-performing methods were applied to the BEACHON-RoMBAS (Bio-hydro-atmosphere interactions of Energy, Aerosols, Carbon, H2O, Organics and Nitrogen-Rocky Mountain Biogenic Aerosol Study) ambient data set, where it was found that the z-score and range normalisation methods yield similar results, with each method producing clusters representative of fungal spores and bacterial aerosol, consistent with previous results. The z-score result was compared to clusters generated with previous approaches (WIBS AnalysiS Program, WASP) where we observe that the subsampling and comparative attribution method employed by WASP results in the overestimation of the fungal spore concentration by a factor of 1.5 and the underestimation of

  15. An innovative method to evaluate the suture compliance in sealing the surgical wound lips

    Directory of Open Access Journals (Sweden)

    Farid Saleh, Beniamino Palmieri, Danielle Lodi, Khalid Al-Sebeih

    2008-01-01

    Full Text Available Background and aim: The increasing number of surgical procedures performed with local anesthesia, followed by immediate patient discharge from the hospital, emphasizes the need for a tight waterproof suture that is capable of maintaining its tensile strength in the postoperative phase when the wound tumescence, edema due to the anesthetic drug, and surgical trauma disappear. Moreover, the issue of having an accurate surgical wound closure is very relevant in vivo in order to prevent hemorrhage and exogenous microbial infections. This study aimed at designing a new a lab technique that could be used for evaluating the best surgical material. Using such a technique, we compared the wound-lip-sealing properties of three commonly-used suture threads, namely polyurethane, polypropylene, and polyamide. Materials and methods: The mechanical properties of same-size suture threads made from polyurethane, polypropylene, and polyamide, were compared in order to define the one that possess the best elastic properties by being able to counteract the tension-relaxation process in the first 12 hours following surgery. The tension holding capacity of the suture materials was measured in both in vivo and in vitro experiments. The surface area of the scar associated with the three different suture threads was measured and compared, and the permeability of the three different suture threads was assessed at 0 minute, 2 minute, 4 minute, 6 minute, and 8 minute- interval. Results: Results showed that polyurethane suture threads had significantly (P < 0.05 better tensile strength, elongation endurance before breakage, and better elasticity coefficient as compared to polypropylene and polyamide suture threads. Moreover, polyurethane suture threads were significantly (P < 0.05 more impermeable as compared to the other two suture thread types (polypropylene and polyamide. This impermeability was also associated with a tighter wound-lip-sealing ability, and with

  16. Substrate-zymography: a still worthwhile method for gelatinases analysis in biological samples.

    Science.gov (United States)

    Ricci, Serena; D'Esposito, Vittoria; Oriente, Francesco; Formisano, Pietro; Di Carlo, Angelina

    2016-08-01

    Matrix metallo-proteinases (MMPs) are a family of zinc-dependent endopeptidases, capable of degrading all the molecular components of extracellular matrix. A class of MMPs is gelatinases which includes gelatinase A or MMP-2 (72 kDa) and gelatinase B or MMP-9 (92 kDa), which have been shown to play critical roles in pathophysiology of many human disease and, in particular, cancer progression. For these reasons they obtained a great interest as potential non-invasive biomarker in providing useful clinical information in cancer diagnosis and therapy. A sensitive and unexpensive method for analysis of gelatinases is the gelatine zymography, which allows to measure the relative amounts of active and inactive enzymes in body fluids and tissue extracts. The procedure involves the electrophoretic separation of proteins under denaturing but non reducing conditions through a polyacrylamide gel containing a synthetic substrate (gelatin). The aim of this mini-review has been to describe the general principles of gelatine zymography technique, underling the main advantages and disadvantages. Even though an improvement of this method is necessary for a better applicability in laboratory medicine, gelatine zymography represents the most convenient method to detect the activity of the different gelatinases from a wide range of biological samples. PMID:26641968

  17. Effects of sterilization methods on the physical, chemical, and biological properties of silk fibroin membranes.

    Science.gov (United States)

    de Moraes, Mariana Agostini; Weska, Raquel Farias; Beppu, Marisa Masumi

    2014-05-01

    Silk fibroin has been widely explored for many biomedical applications, due to its biocompatibility and biodegradability. Sterilization is a fundamental step in biomaterials processing and it must not jeopardize the functionality of medical devices. The aim of this study was to analyze the influence of different sterilization methods in the physical, chemical, and biological characteristics of dense and porous silk fibroin membranes. Silk fibroin membranes were treated by several procedures: immersion in 70% ethanol solution, ultraviolet radiation, autoclave, ethylene oxide, and gamma radiation, and were analyzed by scanning electron microscopy, Fourier-transformed infrared spectroscopy (FTIR), X-ray diffraction, tensile strength and in vitro cytotoxicity to Chinese hamster ovary cells. The results indicated that the sterilization methods did not cause perceivable morphological changes in the membranes and the membranes were not toxic to cells. The sterilization methods that used organic solvent or an increased humidity and/or temperature (70% ethanol, autoclave, and ethylene oxide) increased the silk II content in the membranes: the dense membranes became more brittle, while the porous membranes showed increased strength at break. Membranes that underwent sterilization by UV and gamma radiation presented properties similar to the nonsterilized membranes, mainly for tensile strength and FTIR results. PMID:24259492

  18. Efficiency assessment method of financial leasing as a factor of innovative development of a construction complex for a lessee in comparison with a credit

    Directory of Open Access Journals (Sweden)

    Alekseeva Tat’yana Romanovna

    Full Text Available Modernization and innovative and technological rearmament of a construction complex is one of the priority problems of national economy development. Development and implementation of innovative technologies in the process of creating construction production will allow improving its quality, consumer characteristics, ensuring energy efficiency and ecological safety of buildings and constructions. One of problems of innovative development of a construction complex is the problem of financing of innovative activity. In our opinion leasing is one of effective ways of its solving. In the leasing transaction the owner of an asset temporarily transfers a right to use an asset to other party. The owner of an asset is a lessor. Other party is a lessee. The lessor makes a lease for a specified time in return for a periodic rental payments from the lessee. One of the advantages of leasing is that it provides alternative to ownership. Also lessees benefit from a number of tax advantages. Leasing has many other advantages. The assessment method of the efficiency of financial leasing as a factor of innovative development of a construction complex for a lessee enterprise in comparison with the credit is shown in article. As a result of scientific research we specified the criteria of this assessment.

  19. Proposal of a method to a pro-active action in the technological innovation management in an aerospace public research institution

    Directory of Open Access Journals (Sweden)

    Nestor Brandão Neto

    2010-08-01

    Full Text Available The Aerospace Science and Technology Department (DCTA, acronym in Portuguese has a relevant role. of attending the air force necessities and of incrementing the Brazilian’s global technological capacity. Taking over to a pro-active role in the innovation management is a fundamental step to achieve the strategic goals and it must be faced as a necessary condition for the formation of a favorable environment to disseminate knowledge to the Brazilian industrial sector. This work is based on two approaches: the technological innovation is a cumulative process – which is established by means of the interaction among government, enterprises and R&D institutions, besides the market – and the technological foresight approach, in which the strategic management of the technological innovation implies negotiating demands and promising investigation fields, besides influencing on conditions of the environment in which the actors are inserted, promoting a macro-coordination. This paper presents considerations about the Brazilian aerospace industry and about the technological innovation context at the Defense Ministry and at the Aeronautic Command, specifically at DCTA. The object was to emphasize the necessity of a pro-active strategic action in order to generate technological innovation, and to propose a method of management of this technology for DCTA.

  20. Innovation: definition and management technology

    OpenAIRE

    Oxana O. Klymenko

    2012-01-01

    The article clarifies the essence of the innovation’s concept in the context of management science, identifies the key elements of technology innovation management, existing tools and methods to estimate the innovation efficiency.

  1. Antiviral cationic peptides as a strategy for innovation in global health therapeutics for dengue virus: high yield production of the biologically active recombinant plectasin peptide.

    Science.gov (United States)

    Rothan, Hussin A; Mohamed, Zulqarnain; Suhaeb, Abdulrazzaq M; Rahman, Noorsaadah Abd; Yusof, Rohana

    2013-11-01

    Dengue virus infects millions of people worldwide, and there is no vaccine or anti-dengue therapeutic available. Antimicrobial peptides have been shown to possess effective antiviral activity against various viruses. One of the main limitations of developing these peptides as potent antiviral drugs is the high cost of production. In this study, high yield production of biologically active plectasin peptide was inexpensively achieved by producing tandem plectasin peptides as inclusion bodies in E. coli. Antiviral activity of the recombinant peptide towards dengue serotype-2 NS2B-NS3 protease (DENV2 NS2B-NS3pro) was assessed as a target to inhibit dengue virus replication in Vero cells. Single units of recombinant plectasin were collected after applying consecutive steps of refolding, cleaving by Factor Xa, and nickel column purification to obtain recombinant proteins of high purity. The maximal nontoxic dose (MNTD) of the recombinant peptide against Vero cells was 20 μM (100 μg/mL). The reaction velocity of DENV2 NS2B-NS3pro decreased significantly after increasing concentrations of recombinant plectasin were applied to the reaction mixture. Plectasin peptide noncompetitively inhibited DENV2 NS2B-NS3pro at Ki value of 5.03 ± 0.98 μM. The percentage of viral inhibition was more than 80% at the MNTD value of plectasin. In this study, biologically active recombinant plectasin which was able to inhibit dengue protease and viral replication in Vero cells was successfully produced in E. coli in a time- and cost- effective method. These findings are potentially important in the development of potent therapeutics against dengue infection. PMID:24044366

  2. Collaborative innovation

    DEFF Research Database (Denmark)

    Torfing, Jacob; Sørensen, Eva; Hartley, Jean

    2013-01-01

    There are growing pressures for the public sector to be more innovative but considerable disagreement about how to achieve it. This article uses institutional and organizational analysis to compare three major public innovation strategies. The article confronts the myth that the market......-driven private sector is more innovative than the public sector by showing that both sectors have a number of drivers of as well as barriers to innovation, some of which are similar, while others are sector specific. The article then systematically analyzes three strategies for innovation: New Public Management...... for enhancing public innovation is contingent rather than absolute. Some contingencies for each strategy are outlined....

  3. Innovation in practice, dialogue

    DEFF Research Database (Denmark)

    Reinhard, CarrieLynn D.

    Presentation at the March 19, 2010 project meeting for the Virtual Worlds Research Group.  This presentation is the first report of research conducted in June, 2009, in how the Danish firm Innovation Lab makes sense of innovation as it relates to virtual world technologies.  The method used...... in this study was the focus group, modified using Dervin's Sense-Making Methodology.  This presentation focuses on how the members of Innovation Lab defined what is innovation, with discussion on whether or not having a unified definition within the organization makes the most sense....

  4. Essence: Facilitating Software Innovation

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2008-01-01

      This paper suggests ways to facilitate creativity and innovation in software development. The paper applies four perspectives – Product, Project, Process, and People –to identify an outlook for software innovation. The paper then describes a new facility–Software Innovation Research Lab (SIRL......) – and a new method concept for software innovation – Essence – based on views, modes, and team roles. Finally, the paper reports from an early experiment using SIRL and Essence and identifies further research....

  5. 16 tales of innovation

    DEFF Research Database (Denmark)

    16 Tales of Innovation are told by 16 leaders, who have completed the LAICS executive master program, a collaboration between Aarhus University and Copenhagen Business School. The book is based on their Master theses and illustrates how they have experimented with different innovation tools, mode...... and innovation theories within their own organization. Here they share their unique insights into the processes, methods and the impact of their academic work with innovation in practice.......16 Tales of Innovation are told by 16 leaders, who have completed the LAICS executive master program, a collaboration between Aarhus University and Copenhagen Business School. The book is based on their Master theses and illustrates how they have experimented with different innovation tools, models...

  6. Development of Methods for the Hot Synthesis of S35-Labelled Biologically Active Substances

    International Nuclear Information System (INIS)

    both cases the yield of methionine-S35 amounts to 7-12%. The products in question were separated and identified both chemically and by paper chromatography. In the case of triethylenimine thiophosphoramide biological tests were carried out on the labelled products. The ''hot synthesis'' method thus enables one to obtain complex, biologically active compounds by means of a single-stage process, in many cases without a carrier

  7. Radiation effects analysis in a group of interventional radiologists using biological and physical dosimetry methods

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, M., E-mail: WEMLmirapas@iqn.upv.e [Department of Chemical and Nuclear Engineering, Polytechnic University of Valencia, Camino de Vera s/n, 46022 Valencia (Spain); Montoro, A.; Almonacid, M. [Radiation Protection Service, Hospital Universitario La Fe Valencia (Spain); Ferrer, S. [Department of Chemical and Nuclear Engineering, Polytechnic University of Valencia, Camino de Vera s/n, 46022 Valencia (Spain); Barquinero, J.F. [Biological Dosimetry Service, Unit of Anthropology, Department of Animal and Vegetable Biology and Ecology, Universitat Autonoma de Barcelona (UAB) (Spain); Tortosa, R. [Radiation Protection Service, Hospital Universitario La Fe Valencia (Spain); Verdu, G. [Department of Chemical and Nuclear Engineering, Polytechnic University of Valencia, Camino de Vera s/n, 46022 Valencia (Spain); Rodriguez, P. [Biological Dosimetry Service, Unit of Anthropology, Department of Animal and Vegetable Biology and Ecology, Universitat Autonoma de Barcelona (UAB) (Spain); Barrios, L.L. [Department of Physiology and Cellular Biology, Unit of Cellular Biology (UAB) (Spain); Villaescusa, J.I. [Radiation Protection Service, Hospital Universitario La Fe Valencia (Spain)

    2010-08-15

    Interventional radiologists and staff members are frequently exposed to protracted and fractionated low doses of ionizing radiation, which extend during all their professional activities. These exposures can derive, due to the effects of direct and scattered radiation, in deterministic effects (radiodermitis, aged skin, cataracts, telangiectasia in nasal region, vasocellular epitelioms, hands depilation) and/or stochastic ones (cancer incidence). A methodology has been proposed for estimating the radiation risk or detriment from a group of six exposed interventional radiologists of the Hospital Universitario La Fe (Valencia, Spain), which had developed general exposition symptoms attributable to deterministic effects of ionizing radiation. Equivalent doses have been periodically registered using TLD's and wrist dosimeters, H{sub p}(10) and H{sub p}(0.07), respectively, and estimated through the observation of translocations in lymphocytes of peripheral blood (biological methods), by extrapolating the yield of translocations to their respective dose-effect curves. The software RADRISK has been applied for estimating radiation risks in these occupational radiation exposures. This software is based on transport models from epidemiological studies of population exposed to external sources of ionizing radiation, such as Hiroshima and Nagasaki atomic bomb survivors [UNSCEAR, Sources and effects of ionizing radiation: 2006 report to the general assembly, with scientific annexes. New York: United Nations; 2006]. The minimum and maximum average excess ratio for skin cancer has been, using wrist physical doses, of [1.03x10{sup -3}, 5.06x10{sup -2}], concluding that there is not an increased risk of skin cancer incidence. The minimum and maximum average excess ratio for leukemia has been, using TLD physical doses, of [7.84x10{sup -2}, 3.36x10{sup -1}], and using biological doses, of [1.40x10{sup -1}, 1.51], which is considerably higher than incidence rates, showing an

  8. Detection methods predict differences in biology and survival in breast cancer patients

    International Nuclear Information System (INIS)

    The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences. For this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors. After adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more often than did symptomatic cancers (OR = 3.38, CI = 1.72-6.63 and OR = 3.44, CI = 1.94-6.10, respectively). Furthermore, the expression of bcl-2, a marker of good prognosis in breast cancer, was higher and HER2/neu expression was lower in screen-detected cancers than in symptomatic cancers (OR = 1.77, CI = 1.01-3.23 and OR = 0.64, CI = 0.40-0.98, respectively). However, when comparing prevalent vs incident screen-detected carcinomas, prevalent tumors were larger (OR = 2.84, CI = 1.05-7.69), were less likely to be HER2/neu positive (OR = 0.22, CI = 0.08-0.61) and presented lower Ki67 expression (OR = 0.36, CI = 0.17-0.77). In addition, incident tumors presented a shorter survival time than did prevalent ones (RR = 4.88, CI = 1.12-21.19). Incident carcinomas include a variety of screen-detected carcinomas that exhibit differences in biology and prognosis relative to prevalent carcinomas. The detection method is important and should be taken into account when making therapy decisions

  9. Sparse canonical methods for biological data integration: application to a cross-platform study

    Directory of Open Access Journals (Sweden)

    Robert-Granié Christèle

    2009-01-01

    Full Text Available Abstract Background In the context of systems biology, few sparse approaches have been proposed so far to integrate several data sets. It is however an important and fundamental issue that will be widely encountered in post genomic studies, when simultaneously analyzing transcriptomics, proteomics and metabolomics data using different platforms, so as to understand the mutual interactions between the different data sets. In this high dimensional setting, variable selection is crucial to give interpretable results. We focus on a sparse Partial Least Squares approach (sPLS to handle two-block data sets, where the relationship between the two types of variables is known to be symmetric. Sparse PLS has been developed either for a regression or a canonical correlation framework and includes a built-in procedure to select variables while integrating data. To illustrate the canonical mode approach, we analyzed the NCI60 data sets, where two different platforms (cDNA and Affymetrix chips were used to study the transcriptome of sixty cancer cell lines. Results We compare the results obtained with two other sparse or related canonical correlation approaches: CCA with Elastic Net penalization (CCA-EN and Co-Inertia Analysis (CIA. The latter does not include a built-in procedure for variable selection and requires a two-step analysis. We stress the lack of statistical criteria to evaluate canonical correlation methods, which makes biological interpretation absolutely necessary to compare the different gene selections. We also propose comprehensive graphical representations of both samples and variables to facilitate the interpretation of the results. Conclusion sPLS and CCA-EN selected highly relevant genes and complementary findings from the two data sets, which enabled a detailed understanding of the molecular characteristics of several groups of cell lines. These two approaches were found to bring similar results, although they highlighted the same

  10. Teaching biology through statistics: application of statistical methods in genetics and zoology courses.

    Science.gov (United States)

    Colon-Berlingeri, Migdalisel; Burrowes, Patricia A

    2011-01-01

    Incorporation of mathematics into biology curricula is critical to underscore for undergraduate students the relevance of mathematics to most fields of biology and the usefulness of developing quantitative process skills demanded in modern biology. At our institution, we have made significant changes to better integrate mathematics into the undergraduate biology curriculum. The curricular revision included changes in the suggested course sequence, addition of statistics and precalculus as prerequisites to core science courses, and incorporating interdisciplinary (math-biology) learning activities in genetics and zoology courses. In this article, we describe the activities developed for these two courses and the assessment tools used to measure the learning that took place with respect to biology and statistics. We distinguished the effectiveness of these learning opportunities in helping students improve their understanding of the math and statistical concepts addressed and, more importantly, their ability to apply them to solve a biological problem. We also identified areas that need emphasis in both biology and mathematics courses. In light of our observations, we recommend best practices that biology and mathematics academic departments can implement to train undergraduates for the demands of modern biology. PMID:21885822

  11. Marketing of bank innovations

    Directory of Open Access Journals (Sweden)

    T.A. Vasileva

    2011-01-01

    Full Text Available In the article it is determined the specificity of bank innovations. Level of their introduction in Ukraine is analyse. General tendencies in development of marketing of bank innovations are proved and the scientifically-methodical approach to an estimation of its efficiency is offered.

  12. Fundamentals of bioinformatics and computational biology methods and exercises in matlab

    CERN Document Server

    Singh, Gautam B

    2015-01-01

    This book offers comprehensive coverage of all the core topics of bioinformatics, and includes practical examples completed using the MATLAB bioinformatics toolbox™. It is primarily intended as a textbook for engineering and computer science students attending advanced undergraduate and graduate courses in bioinformatics and computational biology. The book develops bioinformatics concepts from the ground up, starting with an introductory chapter on molecular biology and genetics. This chapter will enable physical science students to fully understand and appreciate the ultimate goals of applying the principles of information technology to challenges in biological data management, sequence analysis, and systems biology. The first part of the book also includes a survey of existing biological databases, tools that have become essential in today’s biotechnology research. The second part of the book covers methodologies for retrieving biological information, including fundamental algorithms for sequence compar...

  13. Applying systems biology methods to the study of human physiology in extreme environments

    OpenAIRE

    Edwards, Lindsay; Thiele, Ines

    2013-01-01

    Systems biology is defined in this review as ‘an iterative process of computational model building and experimental model revision with the aim of understanding or simulating complex biological systems’. We propose that, in practice, systems biology rests on three pillars: computation, the omics disciplines and repeated experimental perturbation of the system of interest. The number of ethical and physiologically relevant perturbations that can be used in experiments on healthy humans is extr...

  14. Innovation surveys

    OpenAIRE

    Tomlinson, Mark

    2010-01-01

    An earlier version of this paper was prepared for the joint OECD/Eurostat workshop on innovation surveys, OECD, Paris, June 30th 1999. The paper addresses some issues about the nature of innovation surveys (particularly the new Community Innovation Surveys) and how they might be improved to take on board several crucial developments in contemporary advanced economies. In particular the following topics are discussed: the increased distribution of innovative activity across firm...

  15. Measuring Innovation

    OpenAIRE

    Cobbe, Brian

    2011-01-01

    The aim of this thesis is to conduct an on-site survey of IKEA Of Sweden, Älmhult (IKEA 2010b), with the aim to determine if IKEA Of Sweden, as an empirical case, innovates within its organization. Measuring innovation is achieved by investigating the level of alignment of the daily operational activities employed by the IKEA Of Sweden organization, with key, modern managerial theorists in the field of innovation and organizational structure; namely, Henry Chesbrough’s Open Innovation paradig...

  16. Brugerdreven innovation

    DEFF Research Database (Denmark)

    Helms, Niels Henrik; Larsen, Lasse Juel

    2007-01-01

    På et generelt plan er vores afsæt et opgør med traditionelle modeller for kreativitet og innovation. Artiklen mener, at brugerdreven innovation ikke bare en god idé, men en beskrivelse af, hvordan innovation finder sted. Vores afsæt er interaktionsdesign, hvor vi bygger på den antagelse...

  17. Organising Innovation

    NARCIS (Netherlands)

    J.C.M. van den Ende (Jan)

    2008-01-01

    textabstractInnovation offers many opportunities for corporations. That is beyond dispute. The only question is how to make the most of them. In this lecture, I show what the process of innovation entails; I give examples of successful and failed innovations and I discuss the current issues and tren

  18. Innovation quality in knowledge cities

    DEFF Research Database (Denmark)

    Makkonen, Teemu; Inkinen, Tommi

    2014-01-01

    competitions and the realized impacts of winning an award are largely the same: media coverage and a credibility boost. The importance of innovation awards in innovation policy was, however, considered only as mediocre or modest. As a conclusion it can be stated that innovation awards are an additional tool......Innovation awards have for long attracted policy makers as a method for innovation promotion. Still, academic research on innovation awards has thus far received little attention. In particular, empirical studies on the motives to enter award competitions and the realized impacts of winning an...

  19. Innovation index for monitoring national innovation systems of Russia and the EU

    OpenAIRE

    Volkova N.N.; Romanyuk E.I.

    2011-01-01

    Innovation index for monitoring national innovation systems of Russia and the EU. Abstract This article focuses on the innovative aspects of monitoring national innovation system. It is based on previous work the authors “Methodic for monitoring the national innovation system of the Russian Federation and international comparisons of innovation ", but more profoundly affect the investment unit of the system for monitoring the national innovation system. Design and analysis of components of th...

  20. Methods of biological fluids sample preparation - biogenic amines, methylxanthines, water-soluble vitamins.

    Science.gov (United States)

    Płonka, Joanna

    2015-01-01

    In recent years demands on the amount of information that can be obtained from the analysis of a single sample have increased. For time and economic reasons it is necessary to examine at the same time larger number of compounds, and compounds from different groups. This can best be seen in such areas as clinical analysis. In many diseases, the best results for patients are obtained when treatment fits the individual characteristics of the patient. Dosage monitoring is important at the beginning of therapy and in the full process of treatment. In the treatment of many diseases biogenic amines (dopamine, serotonin) and methylxanthines (theophylline, theobromine, caffeine) play an important role. They are used as drugs separately or in combination with others to support and strengthen the action of other drugs - for example, the combination of caffeine and paracetamol. Vitamin supplementation may be also an integral part of the treatment process. Specification of complete sample preparation parameters for extraction of the above compounds from biological matrices has been reviewed. Particular attention was given to the preparation stage and extraction methods. This review provides universal guidance on establishing a common procedures across laboratories to facilitate the preparation and analysis of all discussed compounds. PMID:25381720

  1. New Method for Monitoring the Process of Freeze Drying of Biological Materials.

    Science.gov (United States)

    Alkeev, Nikolay; Averin, Stanislav; von Gratowski, Svetlana

    2015-12-01

    A capacitive sensor was proposed and tested for the monitoring and control of a freeze drying process of a vaccine against the Newcastle disease of birds. The residual moisture of the vaccine was measured by the thermogravimetric method. The vaccine activity was determined by titration in chicken embryos. It was shown that, at the stages of freezing and primary drying, a capacitive sensor measured the fraction of unfrozen liquid phase in a material and allowed one to control the sublimation stage of drying in an optimal way. This prevented the foaming of the material and shortened the total drying time approximately twice. The control range at the sublimation stage of drying expanded up to -70°C. It was found at the final stage of drying that the signal of a capacitive sensor passed through a maximum value. We supposed that this maximum corresponds to the minimum of intramolecular mobility of biological macromolecules and hence to the optimal residual moisture of the material, which ensures long-term preservation of its activity. We also suppose that using the capacitive sensor at the final stage of drying allows one to more precisely detect the time when the residual moisture of dried material reaches the optimal value. PMID:26022547

  2. Biological Rhythms Modelisation of Vigilance and Sleep in Microgravity State with COSINOR and Volterra's Kernels Methods

    Science.gov (United States)

    Gaudeua de Gerlicz, C.; Golding, J. G.; Bobola, Ph.; Moutarde, C.; Naji, S.

    2008-06-01

    The spaceflight under microgravity cause basically biological and physiological imbalance in human being. Lot of study has been yet release on this topic especially about sleep disturbances and on the circadian rhythms (alternation vigilance-sleep, body, temperature...). Factors like space motion sickness, noise, or excitement can cause severe sleep disturbances. For a stay of longer than four months in space, gradual increases in the planned duration of sleep were reported. [1] The average sleep in orbit was more than 1.5 hours shorter than the during control periods on earth, where sleep averaged 7.9 hours. [2] Alertness and calmness were unregistered yield clear circadian pattern of 24h but with a phase delay of 4h.The calmness showed a biphasic component (12h) mean sleep duration was 6.4 structured by 3-5 non REM/REM cycles. Modelisations of neurophysiologic mechanisms of stress and interactions between various physiological and psychological variables of rhythms have can be yet release with the COSINOR method. [3

  3. Engineering Bacteria to Search for Specific Concentrations of Molecules by a Systematic Synthetic Biology Design Method

    Science.gov (United States)

    Chen, Bor-Sen

    2016-01-01

    Bacteria navigate environments full of various chemicals to seek favorable places for survival by controlling the flagella’s rotation using a complicated signal transduction pathway. By influencing the pathway, bacteria can be engineered to search for specific molecules, which has great potential for application to biomedicine and bioremediation. In this study, genetic circuits were constructed to make bacteria search for a specific molecule at particular concentrations in their environment through a synthetic biology method. In addition, by replacing the “brake component” in the synthetic circuit with some specific sensitivities, the bacteria can be engineered to locate areas containing specific concentrations of the molecule. Measured by the swarm assay qualitatively and microfluidic techniques quantitatively, the characteristics of each “brake component” were identified and represented by a mathematical model. Furthermore, we established another mathematical model to anticipate the characteristics of the “brake component”. Based on this model, an abundant component library can be established to provide adequate component selection for different searching conditions without identifying all components individually. Finally, a systematic design procedure was proposed. Following this systematic procedure, one can design a genetic circuit for bacteria to rapidly search for and locate different concentrations of particular molecules by selecting the most adequate “brake component” in the library. Moreover, following simple procedures, one can also establish an exclusive component library suitable for other cultivated environments, promoter systems, or bacterial strains. PMID:27096615

  4. Fungal hallucinogens psilocin, ibotenic acid, and muscimol: analytical methods and biologic activities.

    Science.gov (United States)

    Stebelska, Katarzyna

    2013-08-01

    Psychoactive drugs of fungal origin, psilocin, ibotenic acid, and muscimol among them have been proposed for recreational use and popularized since the 1960s, XX century. Despite their well-documented neurotoxicity, they reached reputation of being safe and nonaddictive. Scientific efforts to find any medical application for these hallucinogens in psychiatry, psychotherapy, and even for religious rituals support are highly controversial. Even if they show any healing potential, their usage in psychotherapy is in some cases inadequate and may additionally harm seriously suffering patients. Hallucinogens are thought to reduce cognitive functions. However, in case of indolealkylamines, such as psilocin, some recent findings suggest their ability to improve perception and mental skills, what would motivate the consumption of "magic mushrooms." The present article offers an opportunity to find out what are the main symptoms of intoxication with mushrooms containing psilocybin/psilocin, muscimol, and ibotenic acid. The progress in analytical methods for detection of them in fungal material, food, and body fluids is reviewed. Findings on the mechanisms of their biologic activity are summarized. Additionally, therapeutic potential of these fungal psychoactive compounds and health risk associated with their abuse are discussed. PMID:23851905

  5. Using Active Learning to Teach Concepts and Methods in Quantitative Biology.

    Science.gov (United States)

    Waldrop, Lindsay D; Adolph, Stephen C; Diniz Behn, Cecilia G; Braley, Emily; Drew, Joshua A; Full, Robert J; Gross, Louis J; Jungck, John A; Kohler, Brynja; Prairie, Jennifer C; Shtylla, Blerta; Miller, Laura A

    2015-11-01

    This article provides a summary of the ideas discussed at the 2015 Annual Meeting of the Society for Integrative and Comparative Biology society-wide symposium on Leading Students and Faculty to Quantitative Biology through Active Learning. It also includes a brief review of the recent advancements in incorporating active learning approaches into quantitative biology classrooms. We begin with an overview of recent literature that shows that active learning can improve students' outcomes in Science, Technology, Engineering and Math Education disciplines. We then discuss how this approach can be particularly useful when teaching topics in quantitative biology. Next, we describe some of the recent initiatives to develop hands-on activities in quantitative biology at both the graduate and the undergraduate levels. Throughout the article we provide resources for educators who wish to integrate active learning and technology into their classrooms. PMID:26269460

  6. Comparison of traditional and molecular analytical methods for detecting biological agents in raw and drinking water following ultrafiltration

    Science.gov (United States)

    Francy, D.S.; Bushon, R.N.; Brady, A.M.G.; Bertke, E.E.; Kephart, C.M.; Likirdopulos, C.A.; Mailot, B.E.; Schaefer, F. W., III; Lindquist, H.D. Alan

    2009-01-01

    Aims: To compare the performance of traditional methods to quantitative polymerase chain reaction (qPCR) for detecting five biological agents in large-volume drinking-water samples concentrated by ultrafiltration (UF). Methods and Results: Drinking-water samples (100 l) were seeded with Bacillus anthracis, Cryptospordium parvum, Francisella tularensis, Salmonella Typhi, and Vibrio cholerae and concentrated by UF. Recoveries by traditional methods were variable between samples and between some replicates; recoveries were not determined by qPCR. Francisella tularensis and V. cholerae were detected in all 14 samples after UF, B. anthracis was detected in 13, and C. parvum was detected in 9 out of 14 samples. Numbers found by qPCR after UF were significantly or nearly related to those found by traditional methods for all organisms except for C. parvum. A qPCR assay for S. Typhi was not available. Conclusions: qPCR can be used to rapidly detect biological agents after UF as well as traditional methods, but additional work is needed to improve qPCR assays for several biological agents, determine recoveries by qPCR, and expand the study to other areas. Significance and Impact of the Study: To our knowledge, this is the first study to compare the use of traditional and qPCR methods to detect biological agents in large-volume drinking-water samples. ?? 2009 The Society for Applied Microbiology.

  7. EFFECT OF CORPORATE INNOVATION ABILITY ON THE CHOICE BETWEEN PRODUCT INNOVATION AND PROCESS INNOVATION

    Directory of Open Access Journals (Sweden)

    Zeng Wu

    2010-02-01

    Full Text Available With the method of duopoly game theory, the effect of firms’ innovation ability on the choice between product and process innovation is studied. The concept of cost coefficient of product innovation is introduced, and the criterion equation for the innovation type is derived. The following conclusions are made: the more the product innovation ability, the more the possibility for the firms to carry out the product innovation in both the Bertrand and the Cournot competitions. With the decrease of the product innovation ability, for the high-quality firms, Cournot competitor turns to select the process innovation earlier than the Bertrand competitor. But for the low-quality firms, the Bertrand competitor would select the process innovation firstly.

  8. 基于可拓学的工业设计方法创新研究%Industrial Design Method Innovation Research Based on Extenics

    Institute of Scientific and Technical Information of China (English)

    王金广; 许可

    2014-01-01

    为了解决国内工业设计方法缺乏原创性的问题,通过将可拓学创新方式与工业设计方法相结合,建立了用工业设计语言表述的可拓产品分析法与基于可拓产品分析法的可拓方案优选法模型,用于指导工业设计本土化创新。通过用本土化的设计方法指导国内工业设计创新,让国内生产与设计企业由关注产品自身的设计创新拓展到关注产品价值链的设计创新,增强工业设计在国内发展的适应性,以达到提高国内设计创新效率与增加设计创新产值的目的。%The main purpose is to solve the problem of domestic industrial design lacks original methods. It combines Extenics innovative theory and industrial design methods. This paper puts forward a products design analysis method with Extenics based on industrial design language,based on it,has established a projects evaluation and selection method model with Extenics and uses it to guide the indigenous innovation of industrial design. By using the indigenous industrial design methods to guide domestic design innovation activities,it allows domestic production and design companies focus more on product value chain design innovation, not only in the design of the product itself. It will enhance the ability of industrial design to adapt the development of this country, and to improve the efficiency of domestic design innovation and increase the revenue from design innovation.

  9. Industrial Design Method Innovation Research Based on Extenics%基于可拓学的工业设计方法创新研究

    Institute of Scientific and Technical Information of China (English)

    王金广; 许可

    2014-01-01

    为了解决国内工业设计方法缺乏原创性的问题,通过将可拓学创新方式与工业设计方法相结合,建立了用工业设计语言表述的可拓产品分析法与基于可拓产品分析法的可拓方案优选法模型,用于指导工业设计本土化创新。通过用本土化的设计方法指导国内工业设计创新,让国内生产与设计企业由关注产品自身的设计创新拓展到关注产品价值链的设计创新,增强工业设计在国内发展的适应性,以达到提高国内设计创新效率与增加设计创新产值的目的。%The main purpose is to solve the problem of domestic industrial design lacks original methods. It combines Extenics innovative theory and industrial design methods. This paper puts forward a products design analysis method with Extenics based on industrial design language,based on it,has established a projects evaluation and selection method model with Extenics and uses it to guide the indigenous innovation of industrial design. By using the indigenous industrial design methods to guide domestic design innovation activities,it allows domestic production and design companies focus more on product value chain design innovation, not only in the design of the product itself. It will enhance the ability of industrial design to adapt the development of this country, and to improve the efficiency of domestic design innovation and increase the revenue from design innovation.

  10. Innovation hubs

    DEFF Research Database (Denmark)

    O´Hara, J.; Hansen, Poul H. Kyvsgård; Turner, N.;

    2008-01-01

    "Whilst ‘incremental innovation' is an imperative for the short-to-medium term success of a company, there is also a need for companies to engage in innovation activity that goes beyond the incremental in order to guarantee long-term success. However, such ‘radical innovation' (RI) poses new...... challenges and requires new competencies, some of which may conflict with existing best-practices for incremental innovations. ‘Innovation hubs' are a type of organisational structure dedicated to RI projects that have been used by companies to manage these conflicts by maintaining a certain degree...... of separation from the culture and routines of the mainstream organisation. Unfortunately, it would appear that many attempts to set-up innovation hubs have ended in failure within a few years; not before considerable time, effort and resource has been expended. This paper reports on a study of six innovation...

  11. Introduction: Inequality in Education – Innovation in Methods, with reflections by Dr Nicola Ingram and Professor Melanie Nind

    OpenAIRE

    Carli Ria Rowell; Siobhan Dytham; Nicola Ingram; Melanie Nind

    2015-01-01

    Against a backdrop of metamorphosis in the UK educational landscape and the increased focus on ‘innovation’ in research funding and postgraduate programmes, a conference entitled ‘Inequality in Education – Innovation in Methods’ (IEIM) was held at the University of Warwick in November 2014 to offer space to reflect on ‘inequality in education’ as a field of research and the impact, and future prospect for ‘innovation in method’ in this field. This article introduces this featured section, inc...

  12. Inequality in education – innovation in methods introduction with reflections by Dr Nicola Ingram and Professor Melanie Nind

    OpenAIRE

    Rowell, C.R.; Dytham, S.; Ingham, N.; Nind, Melanie

    2015-01-01

    Against a backdrop of metamorphosis in the UK educational landscape and the increased focus on ‘innovation’ in research funding and postgraduate programmes, a conference entitled ‘Inequality in Education – Innovation in Methods’ (IEIM) was held at the University of Warwick in November 2014 to offer space to reflect on ‘inequality in education’ as a field of research and the impact, and future prospect for ‘innovation in method’ in this field. This article introduces this featured section, inc...

  13. Method development for mass spectrometry based molecular characterization of fossil fuels and biological samples

    Science.gov (United States)

    Mahat, Rajendra K.

    In an analytical (chemical) method development process, the sample preparation step usually determines the throughput and overall success of the analysis. Both targeted and non-targeted methods were developed for the mass spectrometry (MS) based analyses of fossil fuels (coal) and lipidomic analyses of a unique micro-organism, Gemmata obscuriglobus. In the non-targeted coal analysis using GC-MS, a microwave-assisted pressurized sample extraction method was compared with the traditional extraction method, such as Soxhlet. On the other hand, methods were developed to establish a comprehensive lipidomic profile and to confirm the presence of endotoxins (a.k.a. lipopolysaccharides, LPS) in Gemmata.. The performance of pressurized heating techniques employing hot-air oven and microwave irradiation were compared with that of Soxhlet method in terms of percentage extraction efficiency and extracted analyte profiles (via GC-MS). Sub-bituminous (Powder River Range, Wyoming, USA) and bituminous (Fruitland formation, Colorado, USA) coal samples were tested. Overall 30-40% higher extraction efficiencies (by weight) were obtained with a 4 hour hot-air oven and a 20 min microwave-heating extraction in a pressurized container when compared to a 72 hour Soxhlet extraction. The pressurized methods are 25 times more economic in terms of solvent/sample amount used and are 216 times faster in term of time invested for the extraction process. Additionally, same sets of compounds were identified by GC-MS for all the extraction methods used: n-alkanes and diterpanes in the sub-bituminous sample, and n-alkanes and alkyl aromatic compounds in the bituminous coal sample. G. obscuriglobus, a nucleated bacterium, is a micro-organism of high significances from evolutionary, cell and environmental biology standpoints. Although lipidomics is an essential tool in microbiological systematics and chemotaxonomy, complete lipid profile of this bacterium is still lacking. In addition, the presence of

  14. Study on the determination of palladium in biological samples by the method of neutron activation analysis

    International Nuclear Information System (INIS)

    Palladium is one of platinum group elements present in the nature at very low concentrations. However with the use of this element in the automobile catalyzers Pd became a new pollutant. Besides, Pd has been studied in the preparation of new antitumour drugs. Consequently, there is a need to determine Pd concentrations in biological and environmental samples. This study presents palladium results obtained in the analysis of biological samples and reference materials using instrumental thermal and epithermal neutron activation analysis (INAA and ENAA). The solvent extraction and solid phase extraction separation methods were also applied before ENAA. The samples analyzed in this study were, reference material BCR 723 - Palladium, Platinum and Rhodium in road dust, CCQM-P63 automotive catalyst material of the Proficiency Test and bovine tissue samples containing palladium prepared in the laboratory. Samples and palladium synthetic standard were irradiated at the IEA-R1 nuclear research reactor under thermal neutron flux of about 4 x 10 12 n cm-2 s-1, during a period of 4 and 16 h for INAA and ENAA, respectively. The induced gamma activity of 109Pd to the sample and standard was measured using a hyper pure Ge detector coupled to a gamma ray spectrometer. The palladium concentration was calculated by comparative method. The gamma ray energy of 109Pd radioisotope measured was of 88.0 keV, located in a spectrum region of low energy where occurs the interference of X rays, 'Bremsstrahlung' radiations, as well as Compton effect of 24Na. The pre-separation of palladium from interfering elements by solvent extraction was performed using dimethylglyoxime complexant and chloroform as diluent. In the case of the pre separation procedure using solid reversed phase column, the palladium was retained using N,N-diethyl-N'-benzoyl thiourea complexant and eluted using ethanol. Aliquots of the resulting solutions from the pre-separations, free of interfering elements, were transferred

  15. New ways of organizing innovation work

    DEFF Research Database (Denmark)

    Grex, Sara; Møller, Niels

    2006-01-01

    of organizing innovative activities in project-based settings. We propose the Contextual Design method as a way of both studying innovation work processes and an approach to redesign the innovation work organization. We find that the method can contribute to a better understanding of the innovation work...

  16. A review of chromatographic methods for the determination of water- and fat-soluble vitamins in biological fluids.

    Science.gov (United States)

    Karaźniewicz-Łada, Marta; Główka, Anna

    2016-01-01

    Vitamins are an essential element of nutrition and thus contribute to human health. Vitamins catalyze many biochemical reactions and their lack or excess can cause health problems. Therefore, monitoring vitamin concentrations in plasma or other biological fluids may be useful in the diagnosis of various disorders as well as in the treatment process. Several chromatographic methods have been developed for the determination of these compounds in biological samples, including high-performance liquid chromatography with UV and fluorescence detection. Recently, high-performance liquid chromatography with tandem mass spectrometry methods have been widely used for the determination of vitamins in complex matrices because of their high sensitivity and selectivity. This method requires preconditioning of samples for analysis, including protein precipitation and/or various extraction techniques. The choice of method may depend on the desired cost, convenience, turnaround time, specificity, and accuracy of the information to be obtained. This article reviews the recently reported chromatographic methods used for determination of vitamins in biological fluids. Relevant papers published mostly during the last 5 years were identified by an extensive PubMed search using appropriate keywords. Particular attention was given to the preparation steps and extraction techniques. This report may be helpful in the selection of procedures that are appropriate for certain types of biological materials and analytes. PMID:26503668

  17. BICLUSTERING METHODS FOR RE-ORDERING DATA MATRICES IN SYSTEMS BIOLOGY, DRUG DISCOVERY AND TOXICOLOGY

    Directory of Open Access Journals (Sweden)

    Christodoulos A. Floudas

    2010-12-01

    Full Text Available Biclustering has emerged as an important problem in the analysis of gene expression data since genes may only jointly respond over a subset of conditions. Many of the methods for biclustering, and clustering algorithms in general, utilize simplified models or heuristic strategies for identifying the ``best'' grouping of elements according to some metric and cluster definition and thus result in suboptimal clusters. In the first part of the presentation, we present a rigorous approach to biclustering, OREO, which is based on the Optimal RE-Ordering of the rows and columns of a data matrix so as to globally minimize the dissimilarity metric [1,2]. The physical permutations of the rows and columns of the data matrix can be modeled as either a network flow problem or a traveling salesman problem. The performance of OREO is tested on several important data matrices arising in systems biology to validate the ability of the proposed method and compare it to existing biclustering and clustering methods. In the second part of the talk, we will focus on novel methods for clustering of data matrices that are very sparse [3]. These types of data matrices arise in drug discovery where the x- and y-axis of a data matrix can correspond to different functional groups for two distinct substituent sites on a molecular scaffold. Each possible x and y pair corresponds to a single molecule which can be synthesized and tested for a certain property, such as percent inhibition of a protein function. For even moderate size matrices, synthesizing and testing a small fraction of the molecules is labor intensive and not economically feasible. Thus, it is of paramount importance to have a reliable method for guiding the synthesis process to select molecules that have a high probability of success. In the second part of the presentation, we introduce a new strategy to enable efficient substituent reordering and descriptor-free property estimation. Our approach casts

  18. On extracting design principles from biology: I. Method-General answers to high-level design questions for bioinspired robots.

    Science.gov (United States)

    Haberland, M; Kim, S

    2015-01-01

    When millions of years of evolution suggest a particular design solution, we may be tempted to abandon traditional design methods and copy the biological example. However, biological solutions do not often translate directly into the engineering domain, and even when they do, copying eliminates the opportunity to improve. A better approach is to extract design principles relevant to the task of interest, incorporate them in engineering designs, and vet these candidates against others. This paper presents the first general framework for determining whether biologically inspired relationships between design input variables and output objectives and constraints are applicable to a variety of engineering systems. Using optimization and statistics to generalize the results beyond a particular system, the framework overcomes shortcomings observed of ad hoc methods, particularly those used in the challenging study of legged locomotion. The utility of the framework is demonstrated in a case study of the relative running efficiency of rotary-kneed and telescoping-legged robots. PMID:25643176

  19. Garlic breeding system innovations

    NARCIS (Netherlands)

    Zheng, S.J.; Kamenetsky, R.; Féréol, L.; Barandiaran, X.; Rabinowitch, H.D.; Chovelon, V.; Kik, C.

    2007-01-01

    This review outlines innovative methods for garlic breeding improvement and discusses the techniques used to increase variation like mutagenesis and in vitro techniques, as well as the current developments in florogenesis, sexual hybridization, genetic transformation and mass propagation. Sexual ste

  20. STUDIES OF RELATIONSHIPS BETWEEN MOLECULAR STRUCTURE AND BIOLOGICAL ACTIVITY BY PATTERN RECOGNITION METHODS

    Science.gov (United States)

    The attempt to rationalize the connections between the molecular structures of organic compounds and their biological activities comprises the field of structure-activity relations (SAR) studies. Correlations between structure and activity are important for the understanding and ...

  1. Organizational Agility and Complex Enterprise System Innovations: A Mixed Methods Study of the Effects of Enterprise Systems on Organizational Agility

    Science.gov (United States)

    Kharabe, Amol T.

    2012-01-01

    Over the last two decades, firms have operated in "increasingly" accelerated "high-velocity" dynamic markets, which require them to become "agile." During the same time frame, firms have increasingly deployed complex enterprise systems--large-scale packaged software "innovations" that integrate and automate…

  2. A systematic design method for robust synthetic biology to satisfy design specifications

    OpenAIRE

    Wu Chih-Hung; Chen Bor-Sen

    2009-01-01

    Abstract Background Synthetic biology is foreseen to have important applications in biotechnology and medicine, and is expected to contribute significantly to a better understanding of the functioning of complex biological systems. However, the development of synthetic gene networks is still difficult and most newly created gene networks are non-functioning due to intrinsic parameter uncertainties, external disturbances and functional variations of intra- and extra-cellular environments. The ...

  3. Light scattering by irradiated cells as a method of biological dosimetry

    International Nuclear Information System (INIS)

    Light scattering (LS) parameters between 350-500 nm wavelength have been studied for 2 groups of cells: 1) blood (BL) and thymus (TL) lymphocytes of rats and mice, and 2) Ehrlich ascite tumor (EAT) cells. LS measurements of freshly prepared cell suspensions have been made 24 hrs after x-ray irradiation of rodents (250 Kev, HVL = 2 mm Cu) at doses of 50-900 cGy. A steep (30% per Gy) linear (50-800 cGy for TL and 50-400 cGy for BL) dose-dependence was obtained for the increase in 900-angle LS intensity. Increase in absorption (low-angle LS) was also linear (50-800 cGy for TL and BL) but less steep (9% per Gy). Irradiated cells were the same size as unirradiated. Changes in LS for TL and BL appear to follow the appearance of additional vacuoles which may become new internal smaller-size centers of LS. This suggestion is supported by direct observations of cells with dark-field microscopy. For EAT cells, both 900 and low angle LS had the same slope. This slope (4% per Gy) is much shallower than that for BL and TL, and quantitatively coincides with enlargement of area of EAT cells, which could explain LS changes. The difference in LS behavior of the two cellular groups reflects a difference in their early response to irradiation: interphase death for TL and BL, vs division delay for EAT cells. The above data suggest the fast and simple method of biological dosimetry

  4. Characteristics of leachate in Foot and Mouth Disease Carcass Disposal using Molecular Biology Method

    Science.gov (United States)

    Choi, E. J.; Kim, B. J.; Wi, D. W.; Choi, N. C.; Lee, S. J.; Min, J. E.; Park, C. Y.

    2012-04-01

    The Leachate from Foot and Mouth Disease(FMD) carcass disposal by is one of the types of high-concentration contaminated wastewater with the greatest environmental impact. This is due to its pollutants: nitrate nitrogen (NO3--N) and pathogenic microorganisms. Satisfactory treatment of leachate is not an easy task for its high concentrations of nitrate nitrogen and pathogenic microorganisms. Therefore suitable FMD leachate treatment processes should be adopted to improve treatment performance and to reduce overall running costs. The objective of this study was to determine the leachate characteristics through environmental analysis and molecular biology method (bacteria identification and Polymerase Chain Reaction) using FMD leachate samples for optimal FMD leachate treatment processes. The Sixteen FMD leachate samples was obtained from carcass disposal regions in Korea. Results of environmental analysis showed that pH and Eh was observed from 5.57 to 7.40, -134~358mV. This data was exhibited typical early carcass disposal (Neutral pH and Reducing Environment by abundant organic matter). TOC and nitrate nitrogen high concentrations in FMD leachate showed a large variability from 2.3 to 38,730 mg/L(mean - 6,821.93mg/L) and 0.335 ~231.998mg/L(mean - 37.46mg/L), respectively. The result of bacteria identification was observed Bacillus cereus, Pseudomonas putida, Acinetobacter ursingii, Aeromonas hydrophila, Serratia liquefaciens, Brevundimonas naejangsanensis, Serratia liquefaciens, Pseudomonas fluorescens, Pseudomonas aeruginosa, Acinetobacter ursingii. The results of Polymerase Chain Reaction(PCR) using EzTaxon server data revealed Pseudoclavibacter helvolus, Pseudochrobactrum saccharolyticum, Corynebacterium callunae, Paenibacillus lautus, Paenibacillus sp., Bacillus arvi, Brevundimonas bullata, Acinetobacter ursingii, Lysinibacillus sphaericus, Bacillus pumilus, Bacillus sphaericus, Bacillus psychrodurans, Pseudomonas sp.

  5. Colour and organic removal of biologically treated coffee curing wastewater by electrochemical oxidation method

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    The treatment of biologically treated wastewater of coffee-curing industry by the electrochemical oxidation using steel anode were investigated. Bench-scale experiments were conducted for activated sludge process on raw wastewater and the treated effluents were further treated by electrochemical oxidation method for its color and organic content removal. The efficiency of the process was determined in terms of removal percentage of COD, BOD and color during the course of reaction. Several operating parameters like time, pH and current density were examined to ascertain their effects on the treatment efficiency. Steel anode was found to be effective for the COD and color removal with anode efficiency of 0.118 kgCOD-1A-1m-2 and energy consumption 20.61 kWh.kg-1 of COD at pH 9. The decrease in pH from 9 to 3 found to increase the anode efficiency from 0.118 kgCOD-1A-1m-2 to 0.144 kWh.kg-1 of COD while decrease the energy consumption from 20.61 kWh.kg-1 of COD to12 .86 kWh.kg-1 of COD. The pH of 5 was considered an ideal from the present treatment process as it avoids the addition of chemicals for neutralization of treated effluents and also economical with respect to energy consumption. An empirical relation developed for relationship between applied current density and COD removal efficiency showed strong predictive capability with coefficient of determination of 96.5%.

  6. Colour and organic removal of biologically treated coffee curing wastewater by electrochemical oxidation method.

    Science.gov (United States)

    Bejankiwar, Rajesh S; Lokesh, K S; Gowda, T P Halappa

    2003-05-01

    The treatment of biologically treated wastewater of coffee-curing industry by the electrochemical oxidation using steel anode was investigated. Bench-scale experiments were conducted for activated sludge process on raw wastewater and the treated effluents were further treated by electrochemical oxidation method for its colour and organic content removal. The efficiency of the process was determined in terms of removal percentage of COD, BOD and colour during the course of reaction. Several operating parameters like time, pH and current density were examined to ascertain their effects on the treatment efficiency. Steel anode was found to be effective for the COD and colour removal with anode efficiency of 0.118 kgCOD x h(-1) x A(-1) x m(-2) and energy consumption 20.61 kWh x kg(-1) of COD at pH 9. The decrease in pH from 9 to 3 found to increase the anode efficiency from 0.118 kgCOD x h(-1) x A(-1) x m(-2) to 0.144 kWh x kg(-1) of COD while decrease the energy consumption from 20.61 kWh x kg(-1) of COD to 12.86 kWh x kg(-1) of COD. The pH of 5 was considered an ideal from the present treatment process as it avoids the addition of chemicals for neutralization of treated effluents and also economical with respect to energy consumption. An empirical relation developed for relationship between applied current density and COD removal efficiency showed strong predictive capability with coefficient of determination of 96.5%. PMID:12938980

  7. An Innovative Collagen-Based Cell-Printing Method for Obtaining Human Adipose Stem Cell-Laden Structures Consisting of Core-Sheath Structures for Tissue Engineering.

    Science.gov (United States)

    Yeo, MyungGu; Lee, Ji-Seon; Chun, Wook; Kim, Geun Hyung

    2016-04-11

    Three-dimensional (3D) cell printing processes have been used widely in various tissue engineering applications due to the efficient embedding of living cells in appropriately designed micro- or macro-structures. However, there are several issues to overcome, such as the limited choice of bioinks and tailor-made fabricating strategies. Here, we suggest a new, innovative cell-printing process, supplemented with a core-sheath nozzle and an aerosol cross-linking method, to obtain multilayered cell-laden mesh structure and a newly considered collagen-based cell-laden bioink. To obtain a mechanically and biologically enhanced cell-laden structure, we used collagen-bioink in the core region, and also used pure alginate in the sheath region to protect the cells in the collagen during the printing and cross-linking process and support the 3D cell-laden mesh structure. To achieve the most appropriate conditions for fabricating cell-embedded cylindrical core-sheath struts, various processing conditions, including weight fractions of the cross-linking agent and pneumatic pressure in the core region, were tested. The fabricated 3D MG63-laden mesh structure showed significantly higher cell viability (92 ± 3%) compared with that (83 ± 4%) of the control, obtained using a general alginate-based cell-printing process. To expand the feasibility to stem cell-embedded structures, we fabricated a cell-laden mesh structure consisting of core (cell-laden collagen)/sheath (pure alginate) using human adipose stem cells (hASCs). Using the selected processing conditions, we could achieve a stable 3D hASC-laden mesh structure. The fabricated cell-laden 3D core-sheath structure exhibited outstanding cell viability (91%) compared to that (83%) of an alginate-based hASC-laden mesh structure (control), and more efficient hepatogenic differentiations (albumin: ∼ 1.7-fold, TDO-2: ∼ 7.6-fold) were observed versus the control. The selection of collagen-bioink and the new printing strategy

  8. Biological conduit small gap sleeve bridging method for peripheral nerve injury:regeneration law of nerve ifbers in the conduit

    Institute of Scientific and Technical Information of China (English)

    Pei-xun Zhang; Li-ya A; Yu-hui Kou; Xiao-feng Yin; Feng Xue#; Na Han; Tian-bing Wang; Bao-guo Jiang

    2015-01-01

    The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair periph-eral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good his-tocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve ifbers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration (2–8 weeks), the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objec-tive and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

  9. Direct observation of unstained biological specimens in water by the frequency transmission electric-field method using SEM.

    Directory of Open Access Journals (Sweden)

    Toshihiko Ogura

    Full Text Available Scanning electron microscopy (SEM is a powerful tool for the direct visualization of biological specimens at nanometre-scale resolution. However, images of unstained specimens in water using an atmospheric holder exhibit very poor contrast and heavy radiation damage. Here, we present a new form of microscopy, the frequency transmission electric-field (FTE method using SEM, that offers low radiation damage and high-contrast observation of unstained biological samples in water. The wet biological specimens are enclosed in two silicon nitride (SiN films. The metal-coated SiN film is irradiated using a focused modulation electron beam (EB at a low-accelerating voltage. A measurement terminal under the sample holder detects the electric-field frequency signal, which contains structural information relating to the biological specimens. Our results in very little radiation damage to the sample, and the observation image is similar to the transmission image, depending on the sample volume. Our developed method can easily be utilized for the observation of various biological specimens in water.

  10. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit

    Directory of Open Access Journals (Sweden)

    Pei-xun Zhang

    2015-01-01

    Full Text Available The clinical effects of 2-mm small gap sleeve bridging of the biological conduit to repair peripheral nerve injury are better than in the traditional epineurium suture, so it is possible to replace the epineurium suture in the treatment of peripheral nerve injury. This study sought to identify the regeneration law of nerve fibers in the biological conduit. A nerve regeneration chamber was constructed in models of sciatic nerve injury using 2-mm small gap sleeve bridging of a biodegradable biological conduit. The results showed that the biological conduit had good histocompatibility. Tissue and cell apoptosis in the conduit apparently lessened, and regenerating nerve fibers were common. The degeneration regeneration law of Schwann cells and axons in the conduit was quite different from that in traditional epineurium suture. During the prime period for nerve fiber regeneration (2-8 weeks, the number of Schwann cells and nerve fibers was higher in both proximal and distal ends, and the effects of the small gap sleeve bridging method were better than those of the traditional epineurium suture. The above results provide an objective and reliable theoretical basis for the clinical application of the biological conduit small gap sleeve bridging method to repair peripheral nerve injury.

  11. Critical comparison of radiometric and mass spectrometric methods for the determination of radionuclides in environmental, biological and nuclear waste samples

    DEFF Research Database (Denmark)

    Hou, Xiaolin; Roos, Per

    2008-01-01

    application in the environmental and biological researches, these radionuclides include H-3, C-14, Cl-36, Ca-41 Ni-59,Ni-63, Sr-89,Sr-90, Tc-99, I-129, Cs-135,Cs-137, Pb-210, Ra-226,Ra-228, Np-237, Am-241, and isotopes of thorium, uranium and plutonium. The application of on-line methods (flow injection...

  12. Methods and systems for carrying out a pH-influenced chemical and/or biological reaction

    Science.gov (United States)

    Stern, Michael C.; Simeon, Fritz; Hatton, Trevor Alan

    2016-04-05

    The present invention generally relates to methods and systems for carrying out a pH-influenced chemical and/or biological reaction. In some embodiments, the pH-influenced reaction involves the conversion of CO.sub.2 to a dissolved species.

  13. Two Methods of Determining Total Phenolic Content of Foods and Juices in a General, Organic, and Biological (GOB) Chemistry Lab

    Science.gov (United States)

    Shaver, Lee Alan; Leung, Sam H.; Puderbaugh, Amy; Angel, Stephen A.

    2011-01-01

    The determination of total phenolics in foods and fruit juices was used successfully as a laboratory experiment in our undergraduate general, organic, and biological (GOB) chemistry course. Two different colorimetric methods were used over three years and comparative student results indicate that a ferrous ammonium sulfate (FAS) indicator…

  14. Hybrid random walk-linear discriminant analysis method for unwrapping quantitative phase microscopy images of biological samples

    Science.gov (United States)

    Kim, Diane N. H.; Teitell, Michael A.; Reed, Jason; Zangle, Thomas A.

    2015-11-01

    Standard algorithms for phase unwrapping often fail for interferometric quantitative phase imaging (QPI) of biological samples due to the variable morphology of these samples and the requirement to image at low light intensities to avoid phototoxicity. We describe a new algorithm combining random walk-based image segmentation with linear discriminant analysis (LDA)-based feature detection, using assumptions about the morphology of biological samples to account for phase ambiguities when standard methods have failed. We present three versions of our method: first, a method for LDA image segmentation based on a manually compiled training dataset; second, a method using a random walker (RW) algorithm informed by the assumed properties of a biological phase image; and third, an algorithm which combines LDA-based edge detection with an efficient RW algorithm. We show that the combination of LDA plus the RW algorithm gives the best overall performance with little speed penalty compared to LDA alone, and that this algorithm can be further optimized using a genetic algorithm to yield superior performance for phase unwrapping of QPI data from biological samples.

  15. Online Innovation

    DEFF Research Database (Denmark)

    Vujovic, Sladjana; Ulhøi, John Parm

    2008-01-01

      Purpose - The aim of this paper is to investigate the role of online networking during the innovation process, including its role(s) in communication, cooperation and coordination. The paper neither implicitly assumes that online computer-based networking is a prerequisite for the innovation...... process nor denies the possibility that innovation can emerge and successfully survive without it. It merely presupposes that, in cases of innovation where information and communication technologies play a substantial role, non-proprietarity may offer an interesting alternative to innovations based...... on proprietary knowledge. Design/methodology/approach - The paper borrows from the theory of communities-of-practice, which takes into account social relations, contacts, and the transfer and incorporation of knowledge. Open source innovation is not the exclusive preserve of computer nerds, but also has...

  16. Sensitive innovation

    DEFF Research Database (Denmark)

    Søndergaard, Katia Dupret

    Present paper discusses sources of innovation as heterogenic and at times intangible processes. Arguing for heterogeneity and intangibility as sources of innovation originates from a theoretical reading in STS and ANT studies (e.g. Callon 1986, Latour 1996, Mol 2002, Pols 2005) and from field work...... in the area of mental health (Dupret Søndergaard 2009, 2010). The concept of sensitive innovation is developed to capture and conceptualise exactly those heterogenic and intangible processes. Sensitive innovation is therefore primarily a way to understand innovative sources that can be......, but are not necessarily, recognized and acknowledged as such in the outer organisational culture or by management. The added value that qualifies these processes to be defined as “innovative” are thus argued for along different lines than in more traditional innovation studies (e.g. studies that build on the classic...

  17. From low-dimensional model selection to high-dimensional inference: tailoring Bayesian methods to biological dynamical systems

    OpenAIRE

    Hug, Sabine Carolin

    2015-01-01

    In this thesis we use differential equations for mathematically representing biological processes. For this we have to infer the associated parameters for fitting the differential equations to measurement data. If the structure of the ODE itself is uncertain, model selection methods have to be applied. We refine several existing Bayesian methods, ranging from an adaptive scheme for the computation of high-dimensional integrals to multi-chain Metropolis-Hastings algorithms for high-dimensional...

  18. Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked

    DEFF Research Database (Denmark)

    Bauer, Johann; Bussen, Markus; Wise, Petra;

    2016-01-01

    exposed to microgravity conditions. RESEARCH DESIGN AND METHODS: We retrieved publications about microgravity related studies on each type of cell, extracted the proteins mentioned therein and analyzed them subsequently using Pathway Studio aiming to identify biological processes affected by microgravity...... of gravity is common to all the different cell types, at least some of the 19 biological processes could play a role in cellular adaption to microgravity. The application of computer programs, helping to extract and analyze proteins and genes mentioned in publications will become essential for scientists...

  19. Innovation @ NASA

    Science.gov (United States)

    Roman, Juan A.

    2014-01-01

    This presentation provides an overview of the activities National Aeronautics and Space Administration (NASA) is doing to encourage innovation across the agency. All information provided is available publicly.

  20. Near-Real-Time Geophysical and Biological Monitoring of Bioremediation Methods at a Uranium Mill Tailings Site in Rifle, Colorado

    Science.gov (United States)

    Tarrell, A. N.; Haas, A.; Revil, A.; Figueroa, L. A.; Rodriguez, D.; Smartgeo

    2010-12-01

    Bioremediation has been utilized on subsurface uranium contamination at the Rifle IRFC site in Colorado by injecting acetate as an electron donor. However, successfully monitoring the progress of subsurface bioremediation over time is difficult and requires long-term stewardship considerations to ensure cost effective treatment due to biological, chemical, and hydrological heterogeneity. In order to better understand the complex heterogeneities of the subsurface and the resultant effect on microbial activity, innovative subsurface monitoring techniques must be investigated. The key hypothesis of this work is that a combination of data from electrode-based microbial monitoring, self potential monitoring, oxidation reduction potential, and water level sensors will provide sufficient information for identifying and localizing bioremediation activity and will provide better predictions of deleterious biogeochemical change. In order to test the proof-of-concept of these sensing techniques and to deconvolve the redox activity from other electric potential changing events involved in bioremediation, a 2D tank (2.4m x 1.2m x 0.6m) experiment has been developed. Field material obtained from the Rifle IRFC site will be packed in the tank and an artificial groundwater will flow across the tank through constant-head boundaries. The experiment will utilize sensors for electrode-based microbial monitoring, self potential monitoring, oxidation-reduction potential, and water level monitoring. Electrode-based microbial monitoring will be used to estimate microbial activity by measuring how much electrical current indigenous bacteria are producing. Self potential monitoring will be used to measure the natural electrical voltage potential between sampled points, providing indications of when and where electrical activity is occurring; such as reduction of radionuclides. In addition to the application of sensing technologies, this work will explore the application of a wireless sensor

  1. Systems Biology for Smart Crops and Agricultural Innovation: Filling the Gaps between Genotype and Phenotype for Complex Traits Linked with Robust Agricultural Productivity and Sustainability.

    Science.gov (United States)

    Kumar, Anil; Pathak, Rajesh Kumar; Gupta, Sanjay Mohan; Gaur, Vikram Singh; Pandey, Dinesh

    2015-10-01

    In recent years, rapid developments in several omics platforms and next generation sequencing technology have generated a huge amount of biological data about plants. Systems biology aims to develop and use well-organized and efficient algorithms, data structure, visualization, and communication tools for the integration of these biological data with the goal of computational modeling and simulation. It studies crop plant systems by systematically perturbing them, checking the gene, protein, and informational pathway responses; integrating these data; and finally, formulating mathematical models that describe the structure of system and its response to individual perturbations. Consequently, systems biology approaches, such as integrative and predictive ones, hold immense potential in understanding of molecular mechanism of agriculturally important complex traits linked to agricultural productivity. This has led to identification of some key genes and proteins involved in networks of pathways involved in input use efficiency, biotic and abiotic stress resistance, photosynthesis efficiency, root, stem and leaf architecture, and nutrient mobilization. The developments in the above fields have made it possible to design smart crops with superior agronomic traits through genetic manipulation of key candidate genes. PMID:26484978

  2. Electron spin interactions in chemistry and biology fundamentals, methods, reactions mechanisms, magnetic phenomena, structure investigation

    CERN Document Server

    Likhtenshtein, Gertz

    2016-01-01

    This book presents the versatile and pivotal role of electron spin interactions in nature. It provides the background, methodologies and tools for basic areas related to spin interactions, such as spin chemistry and biology, electron transfer, light energy conversion, photochemistry, radical reactions, magneto-chemistry and magneto-biology. The book also includes an overview of designing advanced magnetic materials, optical and spintronic devices and photo catalysts. This monograph appeals to scientists and graduate students working in the areas related to spin interactions physics, biophysics, chemistry and chemical engineering.

  3. The Examination of the Variables Playing a Role on the Process of Adoption of Innovations by Descriptive Review Method

    OpenAIRE

    Avcı, Ümmühan; USLUEL, Yasemin Koçak; KURTOĞLU, Meltem; Uslu, Nilüfer

    2013-01-01

    The purpose of this study is to make a suggestion to researches being published in the literature about diffusion and adoption of instructional technologies. In this way, some criteria were identified by the researchers and a descriptive review was made. As a result of the descriptive review, 65 articles have been reached that meet the criteria. Articles were analyzed in terms of key words, addressed innovation, size of working and tested hypotheses. As a result of the analysis 308 tested hyp...

  4. Biological dosimetry intercomparison exercise: an evaluation of Triage and routine mode results by robust methods

    International Nuclear Information System (INIS)

    Well-defined protocols and quality management standards are indispensable for biological dosimetry laboratories. Participation in periodic proficiency testing by interlaboratory comparisons is also required. This harmonization is essential if a cooperative network is used to respond to a mass casualty event. Here we present an international intercomparison based on dicentric chromosome analysis for dose assessment performed in the framework of the IAEA Regional Latin American RLA/9/054 Project. The exercise involved 14 laboratories, 8 from Latin America and 6 from Europe. The performance of each laboratory and the reproducibility of the exercise were evaluated using robust methods described in ISO standards. The study was based on the analysis of slides from samples irradiated with 0.75 (DI) and 2.5 Gy (DII). Laboratories were required to score the frequency of dicentrics and convert them to estimated doses, using their own dose-effect curves, after the analysis of 50 or 100 cells (triage mode) and after conventional scoring of 500 cells or 100 dicentrics. In the conventional scoring, at both doses, all reported frequencies were considered as satisfactory, and two reported doses were considered as questionable. The analysis of the data dispersion among the dicentric frequencies and among doses indicated a better reproducibility for estimated doses (15.6% for DI and 8.8% for DII) than for frequencies (24.4% for DI and 11.4% for DII), expressed by the coefficient of variation. In the two triage modes, although robust analysis classified some reported frequencies or doses as unsatisfactory or questionable, all estimated doses were in agreement with the accepted error of ±0.5 Gy. However, at the DI dose and for 50 scored cells, 5 out of the 14 reported confidence intervals that included zero dose and could be interpreted as false negatives. This improved with 100 cells, where only one confidence interval included zero dose. At the DII dose, all estimations fell within

  5. Traditional and innovative methods applied to a crystalline aquifer for characterizing fault zone hydrology at different scales

    Science.gov (United States)

    Bour, O.; Ruelleu, S.; Le Borgne, T.; Boudin, F.; Moreau, F.; Durand, S.; Longuevergne, L.

    2011-12-01

    confined aquifer is relatively high, in agreement with ground-surface deformation measurements that suggest a relativity high compressibility of the fault zone. At larger scale, we show through a high-resolution gravimetric survey that the highly fractured contact between granite and micaschists, which constitutes the main path for groundwater flow, is a gently dipping structure. A 3D gravimetric model confirms also the presence of sub-vertical faults that may constitute important drains for the aquifer recharge. In addition, groundwater temperature monitoring allows to shows that the main water supply comes from a depth of at least 300 meters. Such a depth in a low relief region involves relatively deep groundwater circulation that can be achieved only thanks to major permeable fault zone. This field example shows the advantages and limitations of some traditional and innovative methods to characterize fault zone hydrology in crystalline bedrock aquifers.

  6. Innovating the capacity to innovate

    OpenAIRE

    Ingerslev, Karen; Bjørn, Kasper; Johansen, Jørgen

    2012-01-01

    This paper addresses the potential clash between the “non-failure” culture of the hospital and the “fail-fast-forward” approach of innovation by sharing and analysing narratives from a field study of innovation processes. The case is a large university hospital in Scandinavia and the health care sector in general is outlined as context of the challenges addressed by the innovation processes. The narratives fall into three overlapping categories; the product, the process and the...

  7. Reply to the comments on "Comparison of Mann-Kendall and innovative trend method for water quality parameters of the Kizilirmak River, Turkey" by Kisi, O. and Ay, M. [J. Hydrol. 513 (2014) 362-375] and "An innovative method for trend analysis of monthly pan evaporations" by Kisi, O. [J. Hydrol. 527 (2015) 1123-1129

    Science.gov (United States)

    Kisi, Ozgur; Ay, Murat

    2016-07-01

    We thank discusser for his comments on our recent papers about application of innovative trend method (Şen, 2012) for water quality parameters (Kisi and Ay, 2014) and evaporation (Kisi, 2015) and are grateful for having the opportunity to explain and discuss the concerns raised. Illustration of the innovative Şen's trend method with some trend possibilities in the comments by discusser (in Fig. 3 in his discussion) has simple data seem to have normal distribution. However, some data may have highly skewed distribution and indicating trends in these data similar to the Figure 3 as suggested by discusser is impossible. Innovative trend analysis (Şen, 2012) of annual low flows for the duration 14-day (Q14) and 60-day (Q60) in Peterek and Dutdere stations are illustrated in Fig. 1 as an example. In Fig. 1, both half time series are sorted in ascending order. Therefore, Kisi and Ay (2014) provided "a general view" or "imaginative illustration" for the innovative Şen's trend method in Fig. 2 in their study. By this figure, general trend possibilities for any data having different distributions can be shown.

  8. Animated Cell Biology: A Quick and Easy Method for Making Effective, High-Quality Teaching Animations

    Science.gov (United States)

    O'Day, Danton H.

    2006-01-01

    There is accumulating evidence that animations aid learning of dynamic concepts in cell biology. However, existing animation packages are expensive and difficult to learn, and the subsequent production of even short animations can take weeks to months. Here I outline the principles and sequence of steps for producing high-quality PowerPoint…

  9. Biologically Based Methods for Pest Management in Agriculture under Changing Climates: Challenges and Future Directions

    OpenAIRE

    Casper Nyamukondiwa; Frank Chidawanyika; Pride Mudavanhu

    2012-01-01

    The current changes in global climatic regimes present a significant societal challenge, affecting in all likelihood insect physiology, biochemistry, biogeography and population dynamics. With the increasing resistance of many insect pest species to chemical insecticides and an increasing organic food market, pest control strategies are slowly shifting towards more sustainable, ecologically sound and economically viable options. Biologically based pest management strategies present such oppor...

  10. Biologically Based Methods for Pest Management in Agriculture under Changing Climates: Challenges and Future Directions

    Directory of Open Access Journals (Sweden)

    Casper Nyamukondiwa

    2012-11-01

    Full Text Available The current changes in global climatic regimes present a significant societal challenge, affecting in all likelihood insect physiology, biochemistry, biogeography and population dynamics. With the increasing resistance of many insect pest species to chemical insecticides and an increasing organic food market, pest control strategies are slowly shifting towards more sustainable, ecologically sound and economically viable options. Biologically based pest management strategies present such opportunities through predation or parasitism of pests and plant direct or indirect defense mechanisms that can all be important components of sustainable integrated pest management programs. Inevitably, the efficacy of biological control systems is highly dependent on natural enemy-prey interactions, which will likely be modified by changing climates. Therefore, knowledge of how insect pests and their natural enemies respond to climate variation is of fundamental importance in understanding biological insect pest management under global climate change. Here, we discuss biological control, its challenges under climate change scenarios and how increased global temperatures will require adaptive management strategies to cope with changing status of insects and their natural enemies.

  11. New improved method for evaluation of growth by food related fungi on biologically derived materials

    DEFF Research Database (Denmark)

    Bergenholtz, Karina P.; Nielsen, Per Væggemose

    2002-01-01

    Biologically derived materials, obtained as commercial and raw materials (Polylactate (PLA), Polyhydroxybutyrate (PHB), potato, wheat and corn starch) were tested for their ability to support fungal growth using a modified ASTM G21-96 (American Society for Testing and Materials) standard as well...

  12. Responsive Innovation

    DEFF Research Database (Denmark)

    Pedersen, Carsten

    Although the importance of stakeholder networks has been recognized in recent years, a non-teleological model that incorporates their collective sensing into innovation processes has so far not been developed. Hence, this paper argues that traditional linear and sequential innovation models...

  13. Innovation process

    DEFF Research Database (Denmark)

    Kolodovski, A.

    2006-01-01

    Purpose of this report: This report was prepared for RISO team involved in design of the innovation system Report provides innovation methodology to establish common understanding of the process concepts and related terminology The report does not includeRISO- or Denmark-specific cultural, economic...

  14. A Comparative Study of Compression Methods and the Development of CODEC Program of Biological Signal for Emergency Telemedicine Service

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, T.S.; Kim, J.S. [Changwon National University, Changwon (Korea); Lim, Y.H. [Visionite Co., Ltd., Seoul (Korea); Yoo, S.K. [Yonsei University, Seoul (Korea)

    2003-05-01

    In an emergency telemedicine system such as the High-quality Multimedia based Real-time Emergency Telemedicine(HMRET) service, it is very important to examine the status of the patient continuously using the multimedia data including the biological signals(ECG, BP, Respiration, S{sub p}O{sub 2}) of the patient. In order to transmit these data real time through the communication means which have the limited transmission capacity, it is also necessary to compress the biological data besides other multimedia data. For this purpose, we investigate and compare the ECG compression techniques in the time domain and in the wavelet transform domain, and present an effective lossless compression method of the biological signals using JPEG Huffman table for an emergency telemedicine system. And, for the HMRET service, we developed the lossless compression and reconstruction program of the biological signals in MSVC++ 6.0 using DPCM method and JPEG Huffman table, and tested in an internet environment. (author). 15 refs., 17 figs., 7 tabs.

  15. Accidental Innovation

    DEFF Research Database (Denmark)

    Austin, Robert D.; Devin, Lee; Sullivan, Erin E.

    2012-01-01

    Historical accounts of human achievement suggest that accidents can play an important role in innovation. In this paper, we seek to contribute to an understanding of how digital systems might support valuable unpredictability in innovation processes by examining how innovators who obtain value from...... they incorporate accidents into their deliberate processes and arranged surroundings. By comparing makers working in varied conditions, we identify specific factors (e.g., technologies, characteristics of technologies) that appear to support accidental innovation. We show that makers in certain specified...... conditions not only remain open to accident but also intentionally design their processes and surroundings to invite and exploit valuable accidents. Based on these findings, we offer advice for the design of digital systems to support innovation processes that can access valuable unpredictability....

  16. Everyday Innovation

    DEFF Research Database (Denmark)

    Lippke, Lena; Wegener, Charlotte

    2014-01-01

    Purpose – The purpose of this paper is to explore how vocational teachers’ everyday practices can constitute innovative learning spaces that help students to experience engagement and commitment towards education and thus increase their possibilities for completing their studies despite notable...... difficulties. Design/methodology/approach – Based on two ethnographic field studies, we analyse vocational teaching situations in which teachers and students engage in daily remaking of the vocational educational training practice. It is argued that these everyday situations can be understood as innovative...... transformation of participation and practice. Findings – The exploration of teachers’ practicing new learning spaces sheds light on innovation potential embedded in everyday educational practices. The paper thus challenges the celebration of radical innovation and argues that innovation emerges from everyday...

  17. MAPPING INNOVATION

    DEFF Research Database (Denmark)

    Thuesen, Christian Langhoff; Koch, Christian

    2011-01-01

    By adopting a theoretical framework from strategic niche management research (SNM) this paper presents an analysis of the innovation system of the Danish Construction industry. Theories within SNM look upon innovation in a sector as a socio-technical phenomenon and identifies three levels of socio......-technical interaction within which sectorial innovation can be explained. The analysis shows a multifaceted landscape of innovation around an existing regime, built in the existing ways of working and developing over generations. The regime is challenged from various niches and the sociotechnical landscape through...... trends as globalization. Three niches (Lean Construction, BIM and System Deliveries) are subject to a detailed analysis showing partly incompatible rationales and various degrees of innovation potential. The paper further discusses how existing policymaking operates in a number of tensions one being...

  18. Introduction on microbiological and biological methods and their possible combination with other analytical techniques for the detection of irradiated food

    International Nuclear Information System (INIS)

    Food irradiation is a physical method of processing and preserving food. One of the main purposes of the application of this technology to food is to obtain specific biological effects on the treated foodstuff. Typical examples of these treatment effects are listed in the article. A whole range of techniques is at disposal of the analyst to assure the Quality Control (QC) of various foodstuffs. They are based on microbiological, organoleptical, chemical, biochemical, immunological and/or physical methods. In the case of irradiation preserved food the opinion of the writer is that very often only a combination of analytical methods can solve the problem of detection of irradiated foodstuffs and in particular in most cases this combination could be formed by a biological or microbiological method + a chemical or physical one. The meaning of these combination of techniques is manifold. Combining the advantages of a rapid screening method with those of a more refined, reliable, even if more time consuming one; offering the possibility to carry out the analysis for the control of irradiated foodstuffs to different kinds of food control laboratories, often equipped in a different way, are some of the most evident advantages. These methods are briefly explained. At present, none method seems promising for the quantitative determination of the irradiation dose. Moreover, some of the proposed methods can only give a good presumption of the irradiation treatment applied to particular foodstuffs. (18 refs)

  19. Bioconductor: open software development for computational biology and bioinformatics

    DEFF Research Database (Denmark)

    Gentleman, R.C.; Carey, V.J.; Bates, D.M.;

    2004-01-01

    The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisci......The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into...... interdisciplinary scientific research, and promoting the achievement of remote reproducibility of research results. We describe details of our aims and methods, identify current challenges, compare Bioconductor to other open bioinformatics projects, and provide working examples....

  20. USER-DRIVEN INNOVATION: TOWARDS A NEW INNOVATION PARADIGM

    Directory of Open Access Journals (Sweden)

    Slavica Rocheska

    2014-05-01

    Full Text Available The holistic approach to innovation includes establishing a wide range of interactions among different actors which implies development and expansion of methods, approaches and tools for improving the innovation. This paper analyzes the impact of customers and users on promoting innovation of companies. In this context, the authors advocate different methods and approaches for establishing interactions between the customer and the company and for providing the customer involvement in the process of innovation. Therefore, the paper aims at presenting an analytical overview of the methods and tools by which users influence companies’ process of innovation. It will also propose a conceptual framework as regards the user involvement in different stages of the innovation process.