Sample records for biologically effective uniform

  1. The Uniform Rugosity Effect (United States)

    Bonnivard, Matthieu; Bucur, Dorin


    Relying on the effect of microscopic asperities, one can mathematically justify that viscous fluids adhere completely on the boundary of an impermeable domain. The rugosity effect accounts asymptotically for the transformation of complete slip boundary conditions on a rough surface in total adherence boundary conditions, as the amplitude of the rugosities vanishes. The decreasing rate (average velocity divided by the amplitude of the rugosities) computed on close flat layers is definitely influenced by the geometry. Recent results prove that this ratio has a uniform upper bound for certain geometries, like periodical and "almost Lipschitz" boundaries. The purpose of this paper is to prove that such a result holds for arbitrary (non-periodical) crystalline boundaries and general (non-smooth) periodical boundaries.

  2. School Uniform Policies: Students' Views of Effectiveness. (United States)

    McCarthy, Teresa M.; Moreno, Josephine


    Focus-group interviews of New York City middle-school students about their perceptions of the effectiveness of the school-uniform policy. Finds that students' perceptions of the effects of school-uniform policy on school culture varied considerably with those intended by the principal. (Contains 40 references.) (PKP)

  3. Laboratory techniques in plant molecular biology taught with UniformMu insertion alleles of maize (United States)

    An undergraduate course - Laboratory Techniques in Plant Molecular Biology - was organized around our research application of UniformMu insertion alleles to investigate mitochondrial functions in plant reproduction. The course objectives were to develop students’ laboratory, record keeping, bioinfor...

  4. Uniform Effects?: Schools Cite Benefits of Student Uniforms, but Researchers See Little Evidence of Effectiveness (United States)

    Viadero, Debra


    This article reports on the effectiveness of school uniform policies. At Stephen Decatur Middle School, it is the school's policy that all students wear the standard school attire consisting of khaki pants with polo shirts in white, burgundy, or navy blue. Some of the shirts also sport an embroidered Decatur eagle, an optional embellishment.…

  5. Effects of a uniform acceleration on atom-field interactions

    CERN Document Server

    Marino, Jamir; Passante, Roberto; Rizzuto, Lucia; Spagnolo, Salvatore


    We review some quantum electrodynamical effects related to the uniform acceleration of atoms in vacuum. After discussing the energy level shifts of a uniformly accelerated atom in vacuum, we investigate the atom-wall Casimir-Polder force for accelerated atoms, and the van der Waals/Casimir-Polder interaction between two accelerated atoms. The possibility of detecting the Unruh effect through these phenomena is also discussed in detail.

  6. Biologically adapted radiotherapy and evaluation of non-uniform dose distributions

    Energy Technology Data Exchange (ETDEWEB)

    Soevik, Aaste


    imaging of tumor physiological parameters include positron emission tomography (PET) of cellular metabolism and hypoxia, dynamic contrast-enhanced magnetic resonance imaging and computerized tomography (DCEMRI and -CT) of perfusion- and/or permeability-related parameters and blood oxygen level dependent (BOLD) MRI. Conventionally, the desired dose distribution to the tumor has been uniform over the tumor volume. This will optimize the tumor control probability (TCP) in the case of homogeneous tumors, but it will generally not be the optimal dose distribution for tumors with spatial variations in radiation sensitivity. Factors influencing the radiation sensitivity of tumors cells are known to be heterogeneously distributed over the tumor volume. It has been hypothesized that, for a heterogeneous tumor, radiation treatment can be viewed as a selection process, whereby treatment selects for the more resistant subpopulations of tumor cells. Consequently, these cells may come to dominate the response of the tumor to treatment. It follows that, for treatment to be effective, it must successfully eradicate the most resistant fraction of cells in the tumor. However, normal tissue toxicity constrains the radiation dose that can be delivered to the tumor. Hence, in order to maximize TCP for a given mean dose to the tumor, the radiation dose could be redistributed according to the spatial distribution of radiosensitivity in the tumor. This strategy for biological treatment optimization is termed dose redistribution, and could potentially improve locoregional tumor control when treatment response is limited by a radioresistant subpopulation of tumor cells (author)

  7. Rayleigh surface acoustic wave as an efficient heating system for biological reactions: investigation of microdroplet temperature uniformity. (United States)

    Roux-Marchand, Thibaut; Beyssen, Denis; Sarry, Frederic; Elmazria, Omar


    When a microdroplet is put on the Rayleigh surface acoustic wave path, longitudinal waves are radiated into the liquid and induce several phenomena such as the wellknown surface acoustic wave streaming. At the same time, the temperature of the microdroplet increases as it has been shown. In this paper, we study the temperature uniformity of a microdroplet heated by Rayleigh surface acoustic wave for discrete microfluidic applications such as biological reactions. To precisely ascertain the temperature uniformity and not interfere with the biological reaction, we used an infrared camera. We then tested the temperature uniformity as a function of three parameters: the microdroplet volume, the Rayleigh surface acoustic wave frequency, and the continuous applied radio frequency power. Based on these results, we propose a new device structure to develop a future lab on a chip based on reaction temperatures.

  8. Quantum Effects in Biology (United States)

    Mohseni, Masoud; Omar, Yasser; Engel, Gregory S.; Plenio, Martin B.


    List of contributors; Preface; Part I. Introduction: 1. Quantum biology: introduction Graham R. Fleming and Gregory D. Scholes; 2. Open quantum system approaches to biological systems Alireza Shabani, Masoud Mohseni, Seogjoo Jang, Akihito Ishizaki, Martin Plenio, Patrick Rebentrost, Alàn Aspuru-Guzik, Jianshu Cao, Seth Lloyd and Robert Silbey; 3. Generalized Förster resonance energy transfer Seogjoo Jang, Hoda Hossein-Nejad and Gregory D. Scholes; 4. Multidimensional electronic spectroscopy Tomáš Mančal; Part II. Quantum Effects in Bacterial Photosynthetic Energy Transfer: 5. Structure, function, and quantum dynamics of pigment protein complexes Ioan Kosztin and Klaus Schulten; 6. Direct observation of quantum coherence Gregory S. Engel; 7. Environment-assisted quantum transport Masoud Mohseni, Alàn Aspuru-Guzik, Patrick Rebentrost, Alireza Shabani, Seth Lloyd, Susana F. Huelga and Martin B. Plenio; Part III. Quantum Effects in Higher Organisms and Applications: 8. Excitation energy transfer in higher plants Elisabet Romero, Vladimir I. Novoderezhkin and Rienk van Grondelle; 9. Electron transfer in proteins Spiros S. Skourtis; 10. A chemical compass for bird navigation Ilia A. Solov'yov, Thorsten Ritz, Klaus Schulten and Peter J. Hore; 11. Quantum biology of retinal Klaus Schulten and Shigehiko Hayashi; 12. Quantum vibrational effects on sense of smell A. M. Stoneham, L. Turin, J. C. Brookes and A. P. Horsfield; 13. A perspective on possible manifestations of entanglement in biological systems Hans J. Briegel and Sandu Popescu; 14. Design and applications of bio-inspired quantum materials Mohan Sarovar, Dörthe M. Eisele and K. Birgitta Whaley; 15. Coherent excitons in carbon nanotubes Leonas Valkunas and Darius Abramavicius; Glossary; References; Index.

  9. Quantum Effects of Uniform Bose Atomic Gases with Weak Attraction

    Institute of Scientific and Technical Information of China (English)

    CHENG Ze


    @@ We find that uniform Bose atomic gases with weak attraction can undergo a Bardeen-Cooper-Schrieffer(BCS)condensation below a critical temperature.In the BCS condensation state,bare atoms with opposite wave vectors are bound into pairs,and unpaired bare atoms are transformed into a new kind of quasi-particles,i.e.the dressed atoms.The atom-pair system is a condensate or a superfluid and the dressed-atom system is a normal fluid.The critical temperature and the effective mass of dressed atoms are derived analytically.The transition from the BCS condensation state to the normal state is a first-order phase transition.%We find that uniform Bose atomic gases with weak attraction can undergo a Bardeen-Cooper-Schrieffer (BCS)condensation below a critical temperature. In the BCS condensation state, bare atoms with opposite wave vectors are bound into pairs, and unpaired bare atoms are transformed into a new kind of quasi-particles, i.e. the dressed atoms. The atom-pair system is a condensate or a superfluid and the dressed-atom system is a normal fluid. The critical temperature and the effective mass of dressed atoms are derived analytically. The transition from the BCS condensation state to the normal state is a first-order phase transition.

  10. Intelligibility of time-compressed speech: the effect of uniform versus non-uniform time-compression algorithms. (United States)

    Schlueter, Anne; Lemke, Ulrike; Kollmeier, Birger; Holube, Inga


    For assessing hearing aid algorithms, a method is sought to shift the threshold of a speech-in-noise test to (mostly positive) signal-to-noise ratios (SNRs) that allow discrimination across algorithmic settings and are most relevant for hearing-impaired listeners in daily life. Hence, time-compressed speech with higher speech rates was evaluated to parametrically increase the difficulty of the test while preserving most of the relevant acoustical speech cues. A uniform and a non-uniform algorithm were used to compress the sentences of the German Oldenburg Sentence Test at different speech rates. In comparison, the non-uniform algorithm exhibited greater deviations from the targeted time compression, as well as greater changes of the phoneme duration, spectra, and modulation spectra. Speech intelligibility for fast Oldenburg sentences in background noise at different SNRs was determined with 48 normal-hearing listeners. The results confirmed decreasing intelligibility with increasing speech rate. Speech had to be compressed to more than 30% of its original length to reach 50% intelligibility at positive SNRs. Characteristics influencing the discrimination ability of the test for assessing effective SNR changes were investigated. Subjective and objective measures indicated a clear advantage of the uniform algorithm in comparison to the non-uniform algorithm for the application in speech-in-noise tests.


    Directory of Open Access Journals (Sweden)

    D. DUNEA


    Full Text Available The aim of this study was to assess the temperature effect on growth and development parameters in uniform (pure culture and heterogeneous (grass-clover mixture red clover canopies with or without foliar fertilization in the most productive year of red clover. The relationships between biological efficiency (εb, Leaf Area Index (LAI, canopy height growth (Hts, light environment (PAR and temperature in uniform and mixed canopies for both clover ploidy groups are presented. The temperature effect on red clover LAI corresponded to a non-linear sigmoid function. The second foliar fertilizer application had a major effect on leaf area development in uniform canopies. Both ploidy groups had a similar LAI growth trend and favorable responses to foliar fertilization. The correlation between leaf area growth and temperature was statistically significant (p<0.05 for red clover cultivars in the unfertilized grass-clover mixtures. The hybrid ryegrass showed higher regression coefficients in tetraploid clover mixtures (p<0.01. Foliar fertilization determined the smoothing of species behaviors to the temperature regime meaning that the differences between diploids and tetraploids, and between hybrid ryegrass from both variants were less visible.


    Directory of Open Access Journals (Sweden)

    Behzad SANI


    Full Text Available Weeds are a constant problem in agronomy and they not only compete with crops for water, nutrients, sunlight, andspace but also harbor insect and disease pests; clog irrigation and drainage systems; undermine crop quality; anddeposit weed seeds into crop harvests. In order to the microbial herbicide (Orocide influence on seed germinationin Orobancheramosa L., this experiment was conducted in 2011 at Islamic Azad University Shahr-e-Qods Branch inTehran by a completely randomized design with four replications. The factor studied included use of Orocide(0(T1, 2(T2, 4(T3 and 6(T4 percentage. The results showed that the effect of microbial herbicide (Orocide wassignificant on germination percentage of Orobancheramosa. Mean comparison showed that the highest germinationpercentage (79% was achieved by non-application of Orocide and lowest germination percentage (8% wasachieved by application of 4% Orocide.The results of this experiment showed that the use of Orocide can decreasedthe germination in Orobancheramosa L. that is uniform farm operations (UFO very important for weed biologicalcontrol management at Iran.

  13. School Violence and Its Effect on the Constitutionality of Public School Uniform Policies. (United States)

    Starr, Jennifer


    The Arizona Court of Appeals, in the first court decision regarding public school uniform policies, held that mandatory school uniforms do not violate students' First Amendment rights. Discusses the Arizona decision and its effect on the structuring of school uniform policies and their potential successful institution at the high school level. (31…

  14. Quantum Effects in Biological Systems

    CERN Document Server


    Since the last decade the study of quantum mechanical phenomena in biological systems has become a vibrant field of research. Initially sparked by evidence of quantum effects in energy transport that is instrumental for photosynthesis, quantum biology asks the question of how methods and models from quantum theory can help us to understand fundamental mechanisms in living organisms. This approach entails a paradigm change challenging the related disciplines: The successful framework of quantum theory is taken out of its low-temperature, microscopic regimes and applied to hot and dense macroscopic environments, thereby extending the toolbox of biology and biochemistry at the same time. The Quantum Effects in Biological Systems conference is a platform for researchers from biology, chemistry and physics to present and discuss the latest developments in the field of quantum biology. After meetings in Lisbon (2009), Harvard (2010), Ulm (2011), Berkeley (2012), Vienna (2013), Singapore (2014) and Florence (2015),...

  15. Effects of Uniform Target Density on Random Search (United States)



  16. Biological Effectiveness of Antiproton Annihilation

    DEFF Research Database (Denmark)

    Maggiore, C.; Agazaryan, N.; Bassler, N.;


    from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The background, description, and status...

  17. Biological Effects of Acoustic Cavitation (United States)


    rectified diffusion. 56 III. STABLE CAVITATION A. Introduction There are manv areas associated with the biological effects of ultrasound in which the...used said as cavitation indicators. Further, if clinical ultrasound systems are found to be inducing cavitation , either stable or transient, it will...O BIOLOGICAL EFFECTS OF ACOUSTIC CAVITATION by Lawrence A. Crum -- Physical Acoustics Research Laboratory Department of Physics and Astronomy ’ CTE

  18. Effect of Enhancement Technique on Nonuniform and Uniform Ultrasound Images

    Directory of Open Access Journals (Sweden)

    Parveen Lehana


    Full Text Available The absence of adequate scientific resources in the area of medical sciences sometimes leads to improper diagnosis of diseases and hence the treatments of such diseases are affected badly. However, with the advancement of technology, the complicacy of various malfunctions inside the human body reduces. Ultrasound imaging is one of the biomedical scanning techniques that let the pathologist make comment reasonably and accurately on the disease or irregularity seen in the scan while low imaging quality lets the diagnosis go wrong. Even a little distortion can route the pathologist away from the main cause of the disease. In this research work, the enhancement of dark ultrasound images has been done. An algorithm is developed using enhancement technique for nonuniform and uniform dark images. Finally, we compared the quality of the processed and unprocessed images. Both ETNUD and mean and median filtering techniques were used for image analysis.

  19. Mask CD uniformity improvement by electron scanning exposure based Global Loading Effect Correction (United States)

    Li, Rivan; Tian, Eric; Shi, Irene; Guo, Eric; Lu, Max


    Critical Dimension (CD) Uniformity is one of the necessary parameters to assure good performance and reliable functionality of any integrated circuit (IC), and towards the advanced technology node 28nm and beyond, corresponding CD Uniformity becomes more and more crucial. It is found that bad mask CD Uniformity is a significant error source at 28nm process. The CD Uniformity on mask, if not controlled well, will badly impact wafer CD performance, and it has been well-studied that CD Uniformity issue from gate line-width in transistors would affect the device performance directly. In this paper we present a novel solution for mask global CD uniformity error correction, which is called as global loading effect correction (GLEC) method and applied nesting in the mask exposure map during the electron beam exposure. There are factors such as global chip layout, writing sequence and chip pattern density distribution (Global Loading), that work on the whole mask CD Uniformity, especially Global Loading is the key factor related to mask global CD error. From our experimental results, different pattern density distribution on mask significantly influenced the final mask CD Uniformity: the mask with undulating pattern density distribution provides much worse CD Uniformity than that with uniform one. Therefore, a GLEC model based on pattern density has been created to compensate the global error during the electron beam exposure, which has been proved to be efficacious to improve mask global CD Uniformity performance. Furthermore, it 's also revealed that pattern type is another important impact factor, and GLEC coefficient need be modified due to the specific pattern type (e.g. dense line-space only, iso-space only or an average of them) to improve the corresponding mask CD uniformity.

  20. Biological effects of electromagnetic fields. (United States)

    Macrì, M. A.; Di Luzio, Sr.; Di Luzio, S.


    Nowadays, concerns about hazards from electromagnetic fields represent an alarming source for human lives in technologically developed countries. We are surrounded by electromagnetic fields everywhere we spend our working hours, rest or recreational activities. The aim of this review is to summarize the biological effects due to these fields arising from power and transmission lines, electrical cable splices, electronic devices inside our homes and work-places, distribution networks and associated devices such as cellular telephones and wireless communication tower, etc. Special care has been reserved to study the biological effects of electromagnetic fields on cell lines of the mammalian immune system about which our research group has been working for several years.

  1. Investigation and modeling of the avalanche effect in MOSFETs with non-uniform finger spacing

    Institute of Scientific and Technical Information of China (English)

    Liu Jun; Sun Lingling; Marissa Condon


    This paper investigates the effect of a non-uniform gate-finger spacing layout structure on the avalanche breakdown performance of RF CMOS technology.Compared with a standard multi-finger device with uniform gate-finger spacing,a device with non-uniform gate-finger spacing represents an improvement of 8.5% for the drain-source breakdown voltage(BVds)and of 20% for the thermally-related drain conductance.A novel compact model is proposed to accurately predict the variation of BVds with the total area of devices,which is dependent on the different finger spacing sizes.The model is verified and validated by the excellent match between the measured and simulated avalanche breakdown characteristics for a set of uniform and non-uniform gate-finger spacing arranged nMOSFETs.

  2. A Fractal Model for the Effective Thermal Conductivity of Granular Flow with Non-uniform Particles

    Institute of Scientific and Technical Information of China (English)

    ZHANG Duan-Ming; LEI Ya-Jie; YU Bo-Ming; ZHANG Mei-Jun; HUANG Ming-Tao; LI Zhi-Hua; GUAN Li


    The equipartition of energy applied in binary mixture of granular flow is extended to granular flow withnon-uniform particles. Based on the fractal characteristic of granular flow with non-uniform particles as well as energyequipartition, a fractal velocity distribution function and a fractal model of effective thermal conductivity are derived.Thermal conduction resulted from motions of particles in the granular flow, as well as the effect of fractal dimension oneffective thermal conductivity, is discussed.

  3. Biological effectiveness of antiproton annihilation

    CERN Document Server

    Holzscheiter, Michael H.; Bassler, Niels; Beyer, Gerd; De Marco, John J.; Doser, Michael; Ichioka, Toshiyasu; Iwamoto, Keisuke S.; Knudsen, Helge V.; Landua, Rolf; Maggiore, Carl; McBride, William H.; Møller, Søren Pape; Petersen, Jorgen; Smathers, James B.; Skarsgard, Lloyd D.; Solberg, Timothy D.; Uggerhøj, Ulrik I.; Withers, H.Rodney; Vranjes, Sanja; Wong, Michelle; Wouters, Bradly G.


    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in “biological dose” in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current status of the experiment are given.

  4. Biological effectiveness of antiproton annihilation

    DEFF Research Database (Denmark)

    Holzscheiter, M.H.; Agazaryan, N.; Bassler, Niels;


    We describe an experiment designed to determine whether or not the densely ionizing particles emanating from the annihilation of antiprotons produce an increase in ‘‘biological dose’’ in the vicinity of the narrow Bragg peak for antiprotons compared to protons. This experiment is the first direct...... measurement of the biological effects of antiproton annihilation. The experiment has been approved by the CERN Research Board for running at the CERN Antiproton Decelerator (AD) as AD-4/ACE (Antiproton Cell Experiment) and has begun data taking in June of 2003. The background, description and the current...

  5. C-directional compression of nano-graphite: a comparison between effects of uniform and non-uniform pressure (United States)

    Zhu, Chunzhang; Guo, Wanlin


    The mechanism of phase transition and evolution in graphite under uniform compression and spherical nanoindentation along the c-direction is investigated through systematical molecular dynamics simulations. Under both the loading conditions, the soft graphite phase can sustain pressure up to 16-20 GPa, beyond which it transforms into a new phase characterized by a much higher stiffness. More and more interlayer bonds will be created in the new hard phase with the increase of the pressure until an unstable state is reached. The critical pressure to produce the quenchable hard phase with a permanent sp 3 bonding remaining after unloading is shown to be as high as ∼880 GPa under uniform compression, as opposed to only ∼75 GPa under nanoindentation. Therefore, application of non-uniform pressure is significantly more helpful for creating diamond-like sp 3 structures in graphite by cold-compressive technique.

  6. Uniform synthetic magnetic field and effective mass for cold atoms in a shaken optical lattice. (United States)

    Sols, Fernando; Creffield, Charles E.; Pieplow, Gregor; Goldman, Nathan


    Cold atoms can be made to experience synthetic magnetic fields when placed in a suitably driven optical lattice. For coherent systems the switching protocol plays an essential role in determining the long time behavior. Relatively simple driving schemes may generate a uniform magnetic flux but an inhomogeneous effective mass. A two-stage split driving scheme can recover a uniform effective mass but at the price of rendering the magnetic field space dependent. We propose a four-stage split driving that generates uniform field and mass of arbitrary values for all driving amplitudes. Finally, we study a modified two-stage split driving approach that enables uniform field and mass for most of but not all values of the magnetic field. Work supported by MINECO (Spain) under Grant FIS2013-41716-P, by FRS-FNRS (Belgium), and by BSPO under PAI Project No. P7/18 DYGEST.

  7. Decavanadate effects in biological systems. (United States)

    Aureliano, Manuel; Gândara, Ricardo M C


    Vanadium biological studies often disregarded the formation of decameric vanadate species known to interact, in vitro, with high-affinity with many proteins such as myosin and sarcoplasmic reticulum calcium pump and also to inhibit these biochemical systems involved in energy transduction. Moreover, very few in vivo animal studies involving vanadium consider the contribution of decavanadate to vanadium biological effects. Recently, it has been shown that an acute exposure to decavanadate but not to other vanadate oligomers induced oxidative stress and a different fate in vanadium intracellular accumulation. Several markers of oxidative stress analyzed on hepatic and cardiac tissue were monitored after in vivo effect of an acute exposure (12, 24 h and 7 days), to a sub-lethal concentration (5 mM; 1 mg/kg) of two vanadium solutions ("metavanadate" and "decavanadate"). It was observed that "decavanadate" promote different effects than other vanadate oligomers in catalase activity, glutathione content, lipid peroxidation, mitochondrial superoxide anion production and vanadium accumulation, whereas both solutions seem to equally depress reactive oxygen species (ROS) production as well as total intracellular reducing power. Vanadium is accumulated in mitochondria in particular when "decavanadate" is administered. These recent findings, that are now summarized, point out the decameric vanadate species contributions to in vivo and in vitro effects induced by vanadium in biological systems.

  8. Effects of uniform rotational flow on predator-prey system (United States)

    Lee, Sang-Hee


    Rotational flow is often observed in lotic ecosystems, such as streams and rivers. For example, when an obstacle interrupts water flowing in a stream, energy dissipation and momentum transfer can result in the formation of rotational flow, or a vortex. In this study, I examined how rotational flow affects a predator-prey system by constructing a spatially explicit lattice model consisting of predators, prey, and plants. A predation relationship existed between the species. The species densities in the model were given as S (for predator), P (for prey), and G (for plant). A predator (prey) had a probability of giving birth to an offspring when it ate prey (plant). When a predator or prey was first introduced, or born, its health state was assigned an initial value of 20 that subsequently decreased by one with every time step. The predator (prey) was removed from the system when the health state decreased to less than zero. The degree of flow rotation was characterized by the variable, R. A higher R indicates a higher tendency that predators and prey move along circular paths. Plants were not affected by the flow because they were assumed to be attached to the streambed. Results showed that R positively affected both predator and prey survival, while its effect on plants was negligible. Flow rotation facilitated disturbances in individuals’ movements, which consequently strengthens the predator and prey relationship and prevents death from starvation. An increase in S accelerated the extinction of predators and prey.

  9. Quantum Effects in Biological Systems (United States)

    Roy, Sisir


    The debates about the trivial and non-trivial effects in biological systems have drawn much attention during the last decade or so. What might these non-trivial sorts of quantum effects be? There is no consensus so far among the physicists and biologists regarding the meaning of "non-trivial quantum effects". However, there is no doubt about the implications of the challenging research into quantum effects relevant to biology such as coherent excitations of biomolecules and photosynthesis, quantum tunneling of protons, van der Waals forces, ultrafast dynamics through conical intersections, and phonon-assisted electron tunneling as the basis for our sense of smell, environment assisted transport of ions and entanglement in ion channels, role of quantum vacuum in consciousness. Several authors have discussed the non-trivial quantum effects and classified them into four broad categories: (a) Quantum life principle; (b) Quantum computing in the brain; (c) Quantum computing in genetics; and (d) Quantum consciousness. First, I will review the above developments. I will then discuss in detail the ion transport in the ion channel and the relevance of quantum theory in brain function. The ion transport in the ion channel plays a key role in information processing by the brain.

  10. On the resonance effects due to ground wires in transmission lines with non-uniform soil conductivity and non-uniform tower resistances

    Energy Technology Data Exchange (ETDEWEB)

    Faria, J.A. B. (Centro de Electrotecnia da Univ. Tecnica de Lisboa, Dept. of Electrical Engineering, Inst. Superior Tecnico, 1096 Lisboa Codex (PT))


    High frequency resonance effects due to shield wires grounding may affect carrier transmission performance at the vicinity of certain critical frequencies. In this paper the authors investigate if non-uniformities in soil conductivity and in tower footing resistances along the power line may lead to the suppression of such resonance effects. The simulation results the authors have obtained point towards a negative conclusion.

  11. Uniform polyhedra

    CERN Document Server

    Melikhov, Sergey A


    Although topological and uniform approaches to foundations of what was then known as Analysis Situs originated in the same works by M. Frechet and F. Riesz, uniform spaces hopelessly lagged behind in development, and were never taken seriously in algebraic and geometric topology, due in part to the lack of a coherent theory of quotient spaces, and of a reasonable notion of a polyhedron in the uniform category. Yet there are painful side effects of the usual topological foundations: for instance, the non-metrizability of the cone over the real line, and the non-metrizability of RP^\\infty (as a CW-complex or as the geometric realization of a simplicial set). We show that (the topology of) quotient uniformity is, after all, far nicer than quotient topology in the context of metrizable spaces, and that (metrizable, possibly locally infinite-dimensional) uniform polyhedra do exist - and behave nicely - which appears to provide a satisfactory solution to an old open-ended problem by Isbell.

  12. Modeling of Uniform/Non-Uniform Doping Effects for MOSFET Based on BSIM

    Institute of Scientific and Technical Information of China (English)

    ZHAOYang; PARKEStephen; BURKEFranklyn


    In this paper the vertical uniform and nonuniform doping effects for long-channel device (L=2.5μm) of MOSFET are researched where BSIM Model is employed for parameter extraction of doping effects. Further,the description of experiment is introduced to show the process of modeling. Results show that the model and experimental result are in good compliance.

  13. Mitigating the effect of non-uniform loss on time reversal mirrors

    CERN Document Server

    Taddese, Biniyam Tesfaye; Ott, Edward; Anlage, Steven M


    Time reversal mirrors work perfectly only for lossless wave propagation. Here, the performance of time-reversal mirrors is quantitatively defined, and the adverse effect of dissipation on their performance is investigated. The technique of exponential amplification is proposed to overcome the effect of dissipation in the case of uniform loss distributions, and, to some extent, in the case of non-uniform loss distributions. A numerical model of a star graph was employed to test the applicability of this technique on realizations with various random spatial distributions of loss. The numerical results are also verified by an experimental result from an electromagnetic time-reversal mirror.

  14. Effect of intensiti modulated radiation therapy according to equivalent uniform dose optimization method on patients with lung cancer

    Institute of Scientific and Technical Information of China (English)

    Yu-Fu Zhou; Qian Sun; Ya-Jun Zhang; Geng-Ming Wang; Bin He; Tao Qi; An Zhou


    Objective:To analyze the effect of the intensity modulated radiation therapy according to equivalent uniform dose optimization method on patients with lung cancer.Methods:A total of 82 cases of non-small cell lung cancer were divided into observation group and control group according to the random number table method. Patients in the control group received conventional radiotherapy while observation group received intensity modulated radiotherapy based on equivalent uniform dose optimization method. The treatment effects, survival times, blood vessel-related factors, blood coagulation function and the levels of inflammatory factors and so on were compared between the two groups of patients.Results:The effective rate of the observation group after treatment was higher than that of the control group. Progression free survival and median overall survival times were longer than those of patients in the control group (P<0.05). The serum VEGF and HIF-αα levels as well as D-D, TT, PT, APTT and FIB levels were lower in observation group patients after treatment than those in the control group(P<0.05). At the same time point, serum TNF-αα, CRP and PCT levels in the observation group after treatment were lower than those in the control group (P<0.05). Serum M2-PK, CA125, CEA and SCC values of patients in the observation group after treatment were all significantly lower than those in the control group (P< 0.05).Conclusions:Intensity modulated radiation therapy based on equivalent uniform dose optimized method can improve the treatment effect, prolong the survival time, optimize micro inflammatory environment and inhibit tumor biological behavior at the same time.

  15. [Biological effect of wood dust]. (United States)

    Maciejewska, A; Wojtczak, J; Bielichowska-Cybula, G; Domańska, A; Dutkiewicz, J; Mołocznik, A


    The biological effect of exposure to wood dust depends on its composition and the content of microorganisms which are an inherent element of the dust. The irritant and allergic effects of wood dust have been recognised for a long time. The allergic effect is caused by the wood dust of subtropical trees, e.g. western red cedar (Thuja plicata), redwood (Sequoia sempervirens), obeche (Triplochiton scleroxylon), cocabolla (Dalbergia retusa) and others. Trees growing in the European climate such as: larch (Larix), walnut (Juglans regia), oak (Quercus), beech (Fagus), pine (Pinus) cause a little less pronounced allergic effect. Occupational exposure to irritative or allergic wood dust may lead to bronchial asthma, rhinitis, alveolitis allergica, DDTS (Organic dust toxic syndrome), bronchitis, allergic dermatitis, conjunctivitis. An increased risk of adenocarcinoma of the sinonasal cavity is an important and serious problem associated with occupational exposure to wood dust. Adenocarcinoma constitutes about half of the total number of cancers induced by wood dust. An increased incidence of the squamous cell cancers can also be observed. The highest risk of cancer applies to workers of the furniture industry, particularly those dealing with machine wood processing, cabinet making and carpentry. The cancer of the upper respiratory tract develops after exposure to many kinds of wood dust. However, the wood dust of oak and beech seems to be most carcinogenic. It is assumed that exposure to wood dust can cause an increased incidence of other cancers, especially lung cancer and Hodgkin's disease. The adverse effects of microorganisms, mainly mould fungi and their metabolic products are manifested by alveolitis allergica and ODTS. These microorganisms can induce aspergillomycosis, bronchial asthma, rhinitis and allergic dermatitis.

  16. Biological effects of drilling wastes

    Energy Technology Data Exchange (ETDEWEB)

    Cranford, P. J. [Department of Fisheries and Oceans, Dartmouth, NS (Canada). Bedford Inst. of Oceanography


    An argument is made for the point of view that economic realities require that a sustainable fishery must co-exist with the offshore petroleum industry, and therefore to sustain the fishery comprehensive studies are needed to identify and minimize the impact of operational drilling wastes on fishery resources. Moreover, laboratory and field studies indicate that operational drilling platforms impact on fisheries at great distances, therefore studies should not be limited to the immediate vicinity of drilling sites. Studies on long-term exposure of resident organisms to low level contaminants and the chronic lethal and sublethal biological effects of production drilling wastes must be conducted under environmentally relevant conditions to ensure the validity of the results. Studies at the Bedford Institute of Oceanography on sea scallops (Placopecten magellanicus) shows them to be highly sensitive to impacts from drilling wastes. Results of these studies, integrated with toxicity data and information on the distribution and transport of drilling wastes have been used by regulatory agencies and industrial interests to develop scientifically sound and justifiable regulations. They also led to the development of practical, sensitive and cost-effective technologies that use resident resource species to detect environmental impacts at offshore production sites. 1 fig.

  17. Effects of Axial Non-uniform Tip Clearances on Aerodynamic Performance of a Transonic Axial Compressor

    Institute of Scientific and Technical Information of China (English)

    Hongwei MA; Baihe LI


    This paper presents a numerical investigation of effects of axial non-uniform tip clearances on the aerodynamic performance of a transonic axial compressor rotor (NASA Rotor 37). The three-dimensional steady flow field within the rotor passage was simulated with the datum tip clearance of 0.356 mm at the design wheel speed of 17188.7 rpm. The simulation results are well consistent with the measurement results, which verified the numeri-cal method. Then the three-dimensional steady flow field within the rotor passage was simulated respectively with different axial non-uniform tip clearances. The calculation results showed that optimal axial non-uniform tip clearances could improve the compressor performance, while the efficiency and the pressure ratio of the com-pressor were increased. The flow mechanism is that the axial non-uniform tip clearance can weaken the tip leak-age vortex, blow down low-energy fluids in boundary layers and reduce both flow blockage and tip loss.

  18. Study of shear-thinning/thickening effects on plane Couette-Poiseuille flow with uniform crossflow

    Institute of Scientific and Technical Information of China (English)

    刘玉泉; 朱克勤


    The shear-thinning/thickening effects on the plane Couette-Poiseuille flow with a uniform crossflow are studied. The detailed solution procedures for both theo-retical and numerical purposes are given. In order to clarify the difference between the Newtonian flow and the power-law flow, all cases of the plane Couette-Poiseuille flows with uniform crossflows for different power indexes are assigned to the phase diagram in the parameter plane corresponding to the Couette number and the crossflow Reynolds number. The effects of shear-thinning/thickening on the phase diagram are discussed. An important feature of the shear-thinning circumstance distinguished from the shear-thickening circumstance is discovered.

  19. The Role of β-effect and a Uniform Current on Tropical Cyclone Intensity

    Institute of Scientific and Technical Information of China (English)

    端义宏; 伍荣生; 余晖; 梁旭东; 陈仲良


    A limited-area primitive equation model is used to study the role of the β-effect and a uniform current on tropical cyclone (TC) intensity.It is found that TC intensity is reduced in a non-quiescent environment compared with the case of no uniform current.On an f-plane,the rate of intensification of a tropical cyclone is larger than that of the uniform flow.A TC on a β-plane intensifies slower than one on an f-plane.The main physical characteristic that distinguishes the experiments is the asymmetric thermodynamic (including convective) and dynamic structures present when either a uniform flow or β-effect is introduced.But a fairly symmetric TC structure is simulated on an f-plane.The magnitude of the warm core and the associated subsidence are found to be responsible for such simulated intensity changes.On an f-plane,the convection tends to be symmetric,which results in strong upper-level convergence near the center and hence strong forced subsidence and a very warm core.On the other hand,horizontal advection of temperature cancels part of the adiabatic heating and results in less warming of the core,and hence the TC is not as intense.This advective process is due to the tilt of the vortex as a result of the β-effect.A similar situation occurs in the presence of a uniform flow.Thus,the asymmetric horizontal advection of temperature plays an important role in the temperature distribution.Dynamically,the asymmetric angular momentum (AM) flux is very small on an f-plane throughout the troposphere.However,the total AM exports at the upper levels for a TC either on aβ-plane or with a uniform flow environment are larger because of an increase of the asymmetric as well as symmetric AM export on the plane at radii >450 km,and hence there is a lesser intensification.

  20. Do School Uniforms Fit? (United States)

    White, Kerry A.


    In 1994, Long Beach (California) Unified School District began requiring uniforms in all elementary and middle schools. Now, half of all urban school systems and many suburban schools have uniform policies. Research on uniforms' effectiveness is mixed. Tightened dress codes may be just as effective and less litigious. (MLH)

  1. Effect of non-uniform surface resistance on the quality factor of superconducting niobium cavity (United States)

    Tan, Weiwei; Lu, Xiangyang; Yang, Ziqin; Zhao, Jifei; Yang, Deyu; Yang, Yujia


    The formula Rs = G /Q0 is commonly used in the calculation of the surface resistance of radio frequency niobium superconducting cavities. The applying of such equation is under the assumption that surface resistance is consistent over the cavity. However, the distribution of the magnetic field varies over the cavity. The magnetic field in the equator is much higher than that in the iris. According to Thermal Feedback Theory, it leads non-uniform distribution of the density of heat flux, which results in a different temperature distribution along the cavity inter surface. The BCS surface resistance, which depends largely on the temperature, is different in each local inner surface. In this paper, the effect of surface non-uniform resistance on the quality factor has been studied, through the calculation of Q0 in the original definition of it. The results show that it is necessary to consider the non-uniform distribution of magnetic field when the accelerating field is above 20 MV/m for TESLA cavities. Also, the effect of inhomogeneity of residual resistance on the quality factor is discussed. Its distribution barely affects the quality factor.

  2. Elution time changes due to anomalous DEP effects in microchannels under uniform and non-uniform electric fields

    Directory of Open Access Journals (Sweden)

    Antonino Magliano


    Full Text Available Conventional dielectrophoresis (DEP force on cell and particle is altered in the proximity of the electrodes due to the failure of the dipole approximation. In these conditions an anomalous DEP (aDEP force rules the particle manipulation. Anyhow, the role of the aDEP is barely considered in the design of DEP devices. Here we analyze, using a multiscale simulation approach, the aDEP effects in micro-fluidic device coupled with interdigitated channel commonly used in continuous mode field flow fractionation dielectrophoretic (FFF-DEP devices for the separation of circulating tumor cells (MDA and Lymphocytes (LYM. We study the propagation of an injected density of MDA and LYM respectively and evaluate how the aDEP changes the migrations of the cells.


    Directory of Open Access Journals (Sweden)

    R. Muthucumaraswamy


    Full Text Available Thermal radiation effects on unsteady free convective flow of a viscous incompressible flow past an exponentially accelerated infinite isothermal vertical plate with uniform mass diffusion have been studied. An exact solution to the dimensionless governing equations has been obtained by the Laplace transform method. The effects of velocity, temperature and concentration are studied for different parameters like the thermal radiation parameter, Schmidt number, thermal Grashof number, mass Grashof number and time. It is observed that the velocity increases with an increase in the parameter ‘a’.

  4. Effect of Radial Density Configuration on Wave Field and Energy Flow in Axially Uniform Helicon Plasma (United States)

    Chang, Lei; Li, Qingchong; Zhang, Huijie; Li, Yinghong; Wu, Yun; Zhang, Bailing; Zhuang, Zhong


    The effect of the radial density configuration in terms of width, edge gradient and volume gradient on the wave field and energy flow in an axially uniform helicon plasma is studied in detail. A three-parameter function is employed to describe the density, covering uniform, parabolic, linear and Gaussian profiles. It finds that the fraction of power deposition near the plasma edge increases with density width and edge gradient, and decays in exponential and “bump-on-tail” profiles, respectively, away from the surface. The existence of a positive second-order derivative in the volume density configuration promotes the power deposition near the plasma core, which to our best knowledge has not been pointed out before. The transverse structures of wave field and current density remain almost the same during the variation of density width and gradient, confirming the robustness of the m=1 mode observed previously. However, the structure of the electric wave field changes significantly from a uniform density configuration, for which the coupling between the Trivelpiece-Gould (TG) mode and the helicon mode is very strong, to non-uniform ones. The energy flow in the cross section of helicon plasma is presented for the first time, and behaves sensitive to the density width and edge gradient but insensitive to the volume gradient. Interestingly, the radial distribution of power deposition resembles the radial profile of the axial component of current density, suggesting the control of the power deposition profile in the experiment by particularly designing the antenna geometry to excite a required axial current distribution. supported by National Natural Science Foundation of China (No. 11405271)

  5. The Effects on Tsunami Hazard Assessment in Chile of Assuming Earthquake Scenarios with Spatially Uniform Slip (United States)

    Carvajal, Matías; Gubler, Alejandra


    We investigated the effect that along-dip slip distribution has on the near-shore tsunami amplitudes and on coastal land-level changes in the region of central Chile (29°-37°S). Here and all along the Chilean megathrust, the seismogenic zone extends beneath dry land, and thus, tsunami generation and propagation is limited to its seaward portion, where the sensitivity of the initial tsunami waveform to dislocation model inputs, such as slip distribution, is greater. We considered four distributions of earthquake slip in the dip direction, including a spatially uniform slip source and three others with typical bell-shaped slip patterns that differ in the depth range of slip concentration. We found that a uniform slip scenario predicts much lower tsunami amplitudes and generally less coastal subsidence than scenarios that assume bell-shaped distributions of slip. Although the finding that uniform slip scenarios underestimate tsunami amplitudes is not new, it has been largely ignored for tsunami hazard assessment in Chile. Our simulations results also suggest that uniform slip scenarios tend to predict later arrival times of the leading wave than bell-shaped sources. The time occurrence of the largest wave at a specific site is also dependent on how the slip is distributed in the dip direction; however, other factors, such as local bathymetric configurations and standing edge waves, are also expected to play a role. Arrival time differences are especially critical in Chile, where tsunamis arrive earlier than elsewhere. We believe that the results of this study will be useful to both public and private organizations for mapping tsunami hazard in coastal areas along the Chilean coast, and, therefore, help reduce the risk of loss and damage caused by future tsunamis.

  6. Biological effects of high LET radiations

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Masami [Nagasaki Univ. (Japan). Faculty of Pharmaceutical Sciences


    Biological effect of radiation is different by a kind of it greatly. Heavy ions were generally more effective in cell inactivation, chromosome aberration induction, mutation induction and neoplastic cell transformation induction than {gamma}-rays in SHE cells. (author)

  7. Correlation Effects in Biological Networks

    Directory of Open Access Journals (Sweden)

    A.A. Bagdasaryan


    Full Text Available Review of the complex network theory is presented and classification of such networks in accordance with the main statistical characteristics is considered. For the adjacency matrix of a real neural network the shortest distances for each pair of nodes as well as the node degree distribution and cluster coefficients are calculated. Comparison of the main statistical parameters with the random network is performed, and based on this, the conclusions about the correlation phenomena in biological system are made.

  8. Production and use of mycotoxins uniformly enriched with stable isotopes for their dosage in biological samples: (3) Tools for pharmacokinetics and as internal standards

    Energy Technology Data Exchange (ETDEWEB)

    Bravin, F.; Delaforge, M.; Duca, R.C. [CNRS, URA 2096, F-91191 Gif Sur Yvette (France); Bravin, F.; Delaforge, M.; Duca, R.C. [CEA Saclay, DSV, DBJC, SBFM, F-91191 Gif Sur Yvette (France); Pean, M. [CEA Cadarache, DEVM, GRAP, St Paul Les Durance (France); Puel, O. [INRA, Lab Pharmacol Toxicol, UR 66, Toulouse (France)


    Pharmacological studies of exogenous compounds often encounter problems: these compounds are in such infinitesimal amount in their biological matrices, that they require particular detection method. We have implemented an alternative method to the usual radioactivity, based on incorporation of stable isotopes, through the example of biosynthesis of uniformly {sup 13}C enriched mycotoxins. The isotopic cluster obtained from a 10% {sup 13}C enrichment of several mycotoxins (and their metabolites) can be easily recovered from biological tissue samples by mass spectrometry allowing an easy discrimination from natural non-enriched compounds. We illustrate such pharmacological approaches by in vitro zearalenone metabolism. Such enriched compound can also be used as internal standard with high reliability in order to quantify mycotoxins in contaminated food samples. (authors)

  9. An effect of dummy cathode on thickness uniformity in electroforming process

    Directory of Open Access Journals (Sweden)

    Chul-Woo Park


    Full Text Available This study examines the solution for one of the most difficult problems of electroforming process “thickness deviation”. As an effective solution, an auxiliary electrode (dummy cathode is considered. Generally, the thickness of an edge plating area is almost twice the center area or greater. An auxiliary electrode (intentionally attached dummy cathode has helped to achieve more uniform thickness of the electroformed-nickel layer by preventing excessive electric charge. In addition, computer-aided analysis was performed to determine the optimal condition of electroforming process and to confirm the experimental result.

  10. LRRK2 Kinase Activity and Biology are Not Uniformly Predicted by its Autophosphorylation and Cellular Phosphorylation Site Status

    Directory of Open Access Journals (Sweden)

    April eReynolds


    Full Text Available Missense mutations in the Leucine Rich Repeat protein Kinase 2 (LRRK2 gene are the most common genetic predisposition to develop Parkinson’s disease (PD LRRK2 is a large multi-domain phosphoprotein with a GTPase domain and a serine/threonine protein kinase domain whose activity is implicated in neuronal toxicity; however the precise mechanism is unknown. LRRK2 autophosphorylates on several serine/threonine residues across the enzyme and is found constitutively phosphorylated on Ser910, Ser935, Ser955 and Ser973, which are proposed to be regulated by upstream kinases. Here we investigate the phosphoregulation at these sites by analyzing the effects of disease-associated mutations Arg1441Cys, Arg1441Gly, Ala1442Pro, Tyr1699Cys, Ile2012Thr, Gly2019Ser, and Ile2020Thr. We also studied alanine substitutions of phosphosite serines 910, 935, 955 and 973 and specific LRRK2 inhibition on autophosphorylation of LRRK2 Ser1292, Thr1491, Thr2483 and phosphorylation at the cellular sites. We found that mutants in the Roc-COR domains, including Arg1441Cys, Arg1441His, Ala1442Pro and Tyr1699Cys, can positively enhance LRRK2 kinase activity while concomitantly inducing the dephosphorylation of the cellular sites. Mutation of the cellular sites individually did not affect LRRK2 intrinsic kinase activity; however, Ser910/935/955/973Ala mutations trended toward increased kinase activity of LRRK2. Increased cAMP levels did not lead to increased LRRK2 cellular site phosphorylation, 14-3-3 binding or kinase activity. In cells, inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser1292 by Calyculin A and okadaic acid sensitive phosphatases, while the cellular sites are dephosphorylated by Calyculin A sensitive phosphatases. These findings indicate that comparative analysis of both Ser1292 and Ser910/935/955/973 phosphorylation sites will provide important and distinct measures of LRRK2 kinase and biological activity in vitro and in vivo.

  11. Public School Uniforms: Effect on Perceptions of Gang Presence, School Climate, and Student Self-Perceptions. (United States)

    Wade, Kathleen Kiley; Stafford, Mary E.


    Examined the relationship between public school uniforms and student self-worth and student and staff perceptions of gang presence and school climate. Surveys of middle school students and teachers indicated that although students' perceptions did not vary across uniform policy, teachers from schools with uniform policies perceived lower levels of…

  12. Magnetodeformation effects and the swelling of ferrogels in a uniform magnetic field. (United States)

    Filipcsei, Genoveva; Zrínyi, Miklos


    Magnetic field sensitive gels (ferrogels or magnetoelastic gels) are three-dimensional cross-linked networks of flexible polymers swollen by ferrofluids or magnetic fluids. We have studied the response of magnetic field sensitive polymer gels to an external magnetic field. Two phenomena were investigated in detail: deformation and swelling under a uniform magnetic field. Gel spheres containing magnetic particles distributed randomly in the gel matrix as well as pearl chain aggregates chemically fixed in the network were exposed to a static homogeneous magnetic field. It was found that the spatial distribution of the magnetic particles plays an essential role in the magnetodeformation effect. A weak effect was observed for gels containing randomly distributed magnetic particles. In response to the magnetic field induction, these gel spheres elongated along the field lines and were compressed in the perpendicular direction. No magnetodeformation was observed for gels containing aligned particles in the polymer matrix. The influence of an external magnetic field on the equilibrium swelling degree was also the subject of this study. Using thermodynamic arguments it was shown that a uniform external field may result in deswelling of the ferrogels at high field intensities.

  13. Quantum spin Hall effect in a square-lattice model under a uniform magnetic field

    Institute of Scientific and Technical Information of China (English)

    Guo Huai-Ming; Feng Shi-Ping


    We study a toy square-lattice model under a uniform magnetic field.Using the Landauer-Büttiker formula,we calculate the transport properties of the system on a two-terminal,a four-terminal and a six-terminal device.We find that the quantum spin Hall (QSH) effect appears in energy ranges where the spin-up and spin-down subsystems have different filling factors.We also study the robustness of the resulting QSH effect and find that it is robust when the Fermi levels of both spin subsystems are far away from the energy plateaus but is fragile when the Fermi level of any spin subsystem is near the energy plateaus.These results provide an example of the QSH effect with a physical origin other than time-reversal (TR) preserving spin-orbit coupling (SOC).

  14. Highly Uniform Carbon Nanotube Field-Effect Transistors and Medium Scale Integrated Circuits. (United States)

    Chen, Bingyan; Zhang, Panpan; Ding, Li; Han, Jie; Qiu, Song; Li, Qingwen; Zhang, Zhiyong; Peng, Lian-Mao


    Top-gated p-type field-effect transistors (FETs) have been fabricated in batch based on carbon nanotube (CNT) network thin films prepared from CNT solution and present high yield and highly uniform performance with small threshold voltage distribution with standard deviation of 34 mV. According to the property of FETs, various logical and arithmetical gates, shifters, and d-latch circuits were designed and demonstrated with rail-to-rail output. In particular, a 4-bit adder consisting of 140 p-type CNT FETs was demonstrated with higher packing density and lower supply voltage than other published integrated circuits based on CNT films, which indicates that CNT based integrated circuits can reach to medium scale. In addition, a 2-bit multiplier has been realized for the first time. Benefitted from the high uniformity and suitable threshold voltage of CNT FETs, all of the fabricated circuits based on CNT FETs can be driven by a single voltage as small as 2 V.

  15. An explanation for the non-uniform grating effects during recording of diffraction gratings in photopolymers. (United States)

    Blaya, S; Acebal, P; Carretero, L; Murciano, A; Madrigal, R F; Fimia, A


    The recent results reported in reference 1 have produced an increased interest in explaining deviations from the ideal behavior of the energetic variation of the diffraction efficiency of holographic gratings. This ideal behavior occurs when uniform gratings are recorded, and the index modulation is proportional to the energetic exposure. As a result, a typical sin(2) curve is obtained reaching a maximum diffraction efficiency and saturation at or below this value. However, linear deviations are experimentally observed when the first maximum on the curve is lower than the second. This effect does not correspond to overmodulation and recently in PVA/acrylamide photopolymers of high thickness it has been explained by the dye concentration in the layer and the resulting molecular weight of the polymer chains generated in the polymerization process. In this work, new insights into these deviations are gained from the analysis of the non-uniform gratings recorded. Therefore, we show that deviations from the linear response can be explained by taking into account the energetic evolution of the index modulation as well as the fringe bending in the grating.

  16. Water-vortex stabilized electric arc: II. Effect of non-uniform evaporation of water (United States)

    Jenista, Jirí


    The paper deals with a numerical model of an electric arc stabilized by a water vortex. The axisymmetric model involves the area between the cathode and the output nozzle of the arc. The rate of evaporation of water (production of water plasma) is determined from radial conduction and radiation heat fluxes near the water-water-vapour phase transition. The influence of non-uniform evaporation rate along the discharge coordinate on the outlet arc parameters is studied for the currents 300 and 600 A. It is found from calculations that part of the power spent on evaporation is in the range 1.4-3.1% of the total input power. The dominant source of power losses from the arc is plasma radiation, which exceeds conduction losses by a factor of two to four. Since the majority of the arc discharge is nearly thermally fully-developed, the effect of non-uniformity of evaporation on the overall arc performance is minor. The calculated arc outlet characteristics are in good agreement with our data published previously, as well as with experiments carried out on the water plasma torch operating at our Institute.

  17. Non-thermal effects of acceleration in the resonance interaction between two uniformly accelerated identical atoms

    CERN Document Server

    Rizzuto, Lucia; Marino, Jamir; Noto, Antonio; Spagnolo, Salvatore; Passante, Roberto


    We study the resonance interaction between two uniformly accelerated identical atoms, one excited and the other in the ground state, prepared in a correlated (symmetric or antisymmetric) state and interacting with the scalar field in the vacuum state. Because the two atoms are in a correlated state, the interaction is a second-order effect in the atom-field coupling. We separate the contributions of vacuum fluctuations and radiation reaction to the resonance energy shift of the system, and show that only radiation reaction contributes, while Unruh thermal fluctuations do not affect the resonant interatomic interaction. We also find that beyond a characteristic length scale associated to the breakdown of a local inertial description of the two-atom system, non-thermal effects in the radiation reaction correction change the distance-dependence of the resonance interaction. Finally, we generalize our model to the case of atoms interacting with the electromagnetic field, and shown that new features appear in the ...

  18. Effect of Lubrication on the Improvement of Uniformity in Uniaxial Powder Compaction (United States)

    Taniguchi, Yukinori; Dohda, Kuniaki; Wang, Zhrgang

    Density distribution in powder compact caused by frictional force at die wall has been estimated. The pressure transmission ratio λ was defined for the estimation of the magnitude of frictional force occurrence on die wall. The density gradient α was also defined for the estimation of density distribution. The iron and pre-alloyed stainless steel powder were tested, and the performance of zinc stearate and paraffin wax applied as internal lubricant or die wall lubricant has been investigated in various conditions. The die wall lubrication becomes effective way to increase λ in comparison with the internal lubrication. Admixed lubricant prevents the occurrence of density distribution and uniform green compact is obtained in the critical amount of lubricant. Paraffin wax shows higher performance as a die wall lubricant compared with zinc stearate, and remarkable increase of lubrication effect is observed in the combination between zinc stearate as internal lubricant and paraffin wax as wall lubricant.

  19. Effect of disjoining pressure in a thin film equation with non-uniform forcing

    KAUST Repository

    MOULTON, D. E.


    We explore the effect of disjoining pressure on a thin film equation in the presence of a non-uniform body force, motivated by a model describing the reverse draining of a magnetic film. To this end, we use a combination of numerical investigations and analytical considerations. The disjoining pressure has a regularizing influence on the evolution of the system and appears to select a single steady-state solution for fixed height boundary conditions; this is in contrast with the existence of a continuum of locally attracting solutions that exist in the absence of disjoining pressure for the same boundary conditions. We numerically implement matched asymptotic expansions to construct equilibrium solutions and also investigate how they behave as the disjoining pressure is sent to zero. Finally, we consider the effect of the competition between forcing and disjoining pressure on the coarsening dynamics of the thin film for fixed contact angle boundary conditions. Copyright © Cambridge University Press 2013.

  20. On the Effective Thermal Conductivity of Porous Packed Beds with Uniform Spherical Particles (United States)

    Kandula, Max


    Point contact models for the effective thermal conductivity of porous media with uniform spherical inclusions have been briefly reviewed. The model of Zehner and Schlunder (1970) has been further validated with recent experimental data over a broad range of conductivity ratio from 8 to 1200 and over a range of solids fraction up to about 0.8. The comparisons further confirm the validity of Zehner-Schlunder model, known to be applicable for conductivity ratios less than about 2000, above which area contact between the particles becomes significant. This validation of the Zehner-Schlunder model has implications for its use in the prediction of the effective thermal conductivity of water frost (with conductivity ratio around 100) which arises in many important areas of technology.

  1. The effects of non-uniform loss on time reversal mirrors

    Directory of Open Access Journals (Sweden)

    Biniyam Tesfaye Taddese


    Full Text Available Time reversal mirrors work perfectly only for lossless wave propagation; dissipation destroys time-reversal invariance and limits the performance of time-reversal mirrors. Here, a new measure of time-reversal mirror performance is introduced and the adverse effect of dissipation on this performance measure is investigated. The technique of exponential amplification is employed to partially overcome the effect of non-uniform loss distributions, and its success is tested quantitatively using the new performance measure. A numerical model of a star graph is employed to test the applicability of this technique on realizations with various random spatial distributions of loss. A subset of the numerical results are also verified by experimental results from an electromagnetic time-reversal mirror. The exponential amplification technique is a simple way to improve the performance of emerging technologies based on time-reversed wave propagation such as directed communication and wireless power transfer.

  2. The effect of increased ambient lighting on detection accuracy in uniform and anatomical backgrounds (United States)

    Pollard, Benjamin J.; Chawla, Amarpreet S.; Hashimoto, Noriyuki; Samei, Ehsan


    Under typical dark conditions found in reading rooms, a reader's pupils will contract and dilate as the visual focus intermittently shifts between the high luminance monitor and the darker background wall, resulting in increased visual fatigue and the degradation of diagnostic performance. A controlled increase of ambient lighting may, however, minimize these visual adjustments and potentially improve reader comfort and accuracy. This paper details results from two psychophysical studies designed to determine the effect of a controlled ambient lighting increase on observer detection of subtle objects and lesions viewed on a DICOM-calibrated medical-grade LCD. The first study examined the effect of increased ambient lighting on detection of subtle objects embedded within a uniform background, while the second study examined observer detection performance of subtle cancerous lesions in mammograms and chest radiographs. In both studies, observers were presented with images under a dark room condition (1 lux) and an increased room illuminance level (50 lux) for which the luminance level of the diffusely reflected light from the background wall was approximately equal to that of the displayed image. The display was calibrated to an effective luminance ratio of 409 for both lighting conditions. Observer detection performance under each room illuminance condition was then compared. Identification of subtle objects embedded within the uniform background improved from 59% to 67%, while detection time decreased slightly with additional illuminance. An ROC analysis of the anatomical image results revealed that observer AUC values remained constant while detection time decreased under increased illuminance. The results provide evidence that an ambient lighting increase may be possible without compromising diagnostic efficacy.

  3. Biological effects of ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Blaylock, B.G. [SENES Oak Ridge Inc., Oak Ridge, TN (United States); Theodorakis, C.W.; Shugart, L.R. [Oak Ridge National Lab., Oak Ridge, TN (United States). Environmental Sciences Division


    Natural populations have always been exposed to background levels of ionizing radiation; however, with the event of the nuclear age, studies about the effects of higher-than-background levels of ionizing radiation on individuals or populations of organisms became important. Originally, concern was focused on survival after large, acute radiation doses, and numerous studies document the somatic and genetic effects of acute ionizing radiation. However, there is a growing realization that chronic long-term exposure to higher-than-background levels of environmental radiation is more likely than is large acute exposure. Less than 10% of the literature on ionizing radiation effects deals with chronic long-term effects, and very few studies involve natural populations. In 1977, mosquito fish, Gambusia affinis, were experimentally introduced into a 0,45 ha, decommissioned, radioactive waste pond where the measured dose at the sediment-water interface was 1,150 rad/year. One year later, the fecundity of the population had not changed significantly. Eighteen years later, studies of the fish showed an inverse correlation between DNA strand breakage and fecundity in the contaminated pond. More recent studies have provided evidence that genetic diversity of the fish has increased in the contaminated site. These fish also have a greater prevalence of certain DNA banding patterns. Individuals displaying these banding patterns have a higher fecundity and lower degree of DNA strand breakage than individuals with less common banding patterns. Gambusia affinis has apparently adapted to the high background radiation, successfully surviving for approximately 50 generations. 31 refs, 5 figs.

  4. Reproducibility of Uniform Spheroid Formation in 384-Well Plates: The Effect of Medium Evaporation. (United States)

    Das, Viswanath; Fürst, Tomáš; Gurská, Soňa; Džubák, Petr; Hajdúch, Marián


    Spheroid cultures of cancer cells reproduce the spatial dimension-induced in vivo tumor traits more effectively than the conventional two-dimensional cell cultures. With growing interest in spheroids for high-throughput screening (HTS) assays, there is an increasing demand for cost-effective miniaturization of reproducible spheroids in microtiter plates (MPs). However, well-to-well variability in spheroid size, shape, and growth is a frequently encountered problem with almost every culture method that has prevented the transfer of spheroids to the HTS platform. This variability partly arises due to increased susceptibility of MPs to edge effects and evaporation-induced changes in the growth of spheroids. In this study, we examined the effect of evaporation on the reproducibility of spheroids of tumor and nontumor cell lines in 384-well plates, and show that culture conditions that prevent evaporation-induced medium loss result in the formation of uniform spheroids across the plate. Additionally, we also present a few technical improvements to increase the scalability of the liquid-overlay spheroid culturing technique in MPs, together with a simple software routine for the quantification of spheroid size. We believe that these cost-effective improvements will aid in further improvement of spheroid cultures for HTS drug discovery.

  5. Bed Slope Effect on Non-uniform Flow through Porous Media (United States)

    Bhanu Prakasham Reddy, N.; Krishnaiah, S.; Ramakrishna Reddy, M.


    The tilting angle or bed slope (φ) effect on piezometric head was studied in a tilting angle converging permeameter for different rate of flows and for different bed slopes or tilting angles (φ) and the equipotential lines of piezometric head are depicted pictorially to establish the suitability of the convergent flow assumption and have a proper insight into the subject of seepage flow. The porosity effect is considered while computing seepage velocity (V), linear parameter, non-linear parameter, increases with decrease of porosity (N) and increases with decrease of angle of inclination. In order to meet the objective of this study, a crushed rock of size 7.30 mm was used as media and water as fluid, to develop curves relating friction factor (FR) and Reynolds number (RR) for different ratios of width using hydraulic radius (R) as characteristic length for different bed slopes or tilting angles (φ). The effect of varying tilting angles (φ) on head loss of fluid flow through porous media when packed between convergent boundaries for different ratios of width (B1/B2) was studied and inferred that tilting angles (φ) have a significant effect on the non uniform flow.

  6. Spectral non-uniform temperature and non-local heat transfer in the spin Seebeck effect. (United States)

    Tikhonov, Konstantin S; Sinova, Jairo; Finkel'stein, Alexander M


    Recently discovered spin-dependent thermoelectric effects have merged spin, charge, and thermal physics, known as spin caloritronics, of which the spin Seebeck effect is its most puzzling. Here we present a theory of this effect driven by subthermal non-local phonon heat transfer and spectral non-uniform temperature. The theory explains its non-local behaviour from the fact that phonons that store the energy (thermal) and the phonons that transfer it (subthermal) are located in different parts of the spectrum and have different kinetics. This gives rise to a spectral phonon distribution that deviates from local equilibrium along the substrate and is sensitive to boundary conditions. The theory also predicts a non-magnon origin of the effect in ferromagnetic metals in agreement with observations in recent experiments. Equilibration of the heat flow from the substrate to the Pt probe and backwards leads to a vertical spin current produced by the spin-polarized electrons dragged by the thermal phonons.

  7. Edge effect causes apparent fractal correlation dimension of uniform spatial raindrop distribution

    Directory of Open Access Journals (Sweden)

    R. Uijlenhoet


    Full Text Available Lovejoy and Schertzer (1990a presented a statistical analysis of blotting paper observations of the (two-dimensional spatial distribution of raindrop stains. They found empirical evidence for the fractal scaling behavior of raindrops in space, with potentially far-reaching implications for rainfall microphysics and radar meteorology. In particular, the fractal correlation dimensions determined from their blotting paper observations led them to conclude that "drops are (hierarchically clustered" and that "inhomogeneity in rain is likely to extend down to millimeter scales". Confirming previously reported Monte Carlo simulations, we demonstrate analytically that the claims based on this analysis need to be reconsidered, as fractal correlation dimensions similar to the ones reported (i.e. smaller than the value of two expected for uniformly distributed raindrops can result from instrumental artifacts (edge effects in otherwise homogeneous Poissonian rainfall. Hence, the results of the blotting paper experiment are not statistically significant enough to reject the Poisson homogeneity hypothesis in favor of a fractal description of the discrete nature of rainfall. Our analysis is based on an analytical expression for the expected overlap area between a circle and a square, when the circle center is randomly (uniformly distributed inside the square. The derived expression (πr2−8r3/3+r4/2, where r denotes the ratio between the circle radius and the side of the square can be used as a reference curve against which to test the statistical significance of fractal correlation dimensions determined from spatial point patterns, such as those of raindrops and rainfall cells.

  8. Biological Effects of Low-Dose Exposure

    CERN Document Server

    Komochkov, M M


    On the basis of the two-protection reaction model an analysis of stochastic radiobiological effects of low-dose exposure of different biological objects has been carried out. The stochastic effects are the results published in the last decade: epidemiological studies of human cancer mortality, the yield of thymocyte apoptosis of mice and different types of chromosomal aberrations. The results of the analysis show that as dependent upon the nature of biological object, spontanous effect, exposure conditions and radiation type one or another form dose - effect relationship is realized: downwards concave, near to linear and upwards concave with the effect of hormesis included. This result testifies to the incomplete conformity of studied effects of 1990 ICRP recomendations based on the linear no-threshold hypothesis about dose - effect relationship. Because of this the methodology of radiation risk estimation recomended by ICRP needs more precisian and such quantity as collective dose ought to be classified into...

  9. Biological Effect of Magnetic Field in Mice

    Institute of Scientific and Technical Information of China (English)

    Zhao-Wei ZENG


    Objective: To study the biological effect of magnetic field in mice bodies. Method: With a piece of permanent magnet embeded in mice bodies beside the femoral artery and vein to measure the electrophoretic velocity(um/s). Result: The magnetic field in mice bodies on the experiment group that the electrophoretic velocity is faster more than control and free group.Conclusion:The magnetic field in animal's body can raise the negative electric charges on the surface of erythrocyte to improve the microcirculation, this is the biological effect of magnetic field.

  10. Biological effects of electric fields: an overview

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, L.E.; Phillips, R.D.


    An overview of the literature suggests tha electric-field exposure is an environmental agent/influence of relatively low potential toxicity to biological systems. Generally, many of the biological effects which have been reported are quite subtle and differences between exposed and unexposed subjects may be masked by normal biological variations. However, several recent reports indicate possibly more serious consequences from chronic exposure, emphasizing the need for more research in epidemiology and laboratory experiments. This paper presents a cursory overview of investigations on the biological consequences of exposure to ELF electromagnetic fields. Three important topics are discussed, including: 1) the general methodology of exposure experiments, including those elements which are critical for definitive studies in biological systems; 2) a brief discussion of epidemiological and clinical studies conducted to date; and 3) a somewhat more extensive examination of animal experiments representing major areas of investigation (behavior, biological rhythms, nervous and endocrine systems, bone growth and repair, cardiovascular system and blood chemistry, immunology, reproduction, growth and development mortality and pathology, cellular and membrane studies, and mutagenesis). A discussion of current concepts, possible mechanisms and future directions of research is presented. 110 references.

  11. Biological effectiveness of neutrons: Research needs

    Energy Technology Data Exchange (ETDEWEB)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.


    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  12. The Effect of Non-Uniform Wetting Properties on Contact Line Dynamics (United States)

    Grivel, Morgane; Jeon, David; Gharib, Morteza


    Surfaces with non-uniform wetting properties have been shown to modify contact line dynamics and induce passive displacements of shallow flows. These surfaces are patterned with alternating hydrophobic and hydrophilic stripes of a certain width, spacing and orientation. A thin rectangular wall jet impinges on the surfaces and Fourier Transform Profilometry is used to reconstruct the 3D profile of the low to medium Reynolds number flows. Our previous work reported the development of intriguing roller structures at the contact line near hydrophobic-hydrophilic interfaces and the effect of varying the stripes' dimensions and orientation on these flows. Our present work extends the study to the effects of flow rate and plate inclination angle (with respect to the horizontal). The current work also studies air entrainment by the roller structures of the modified contact line. We will also discuss potential uses of this technique for modifying contact line dynamics and bow waves near surface-piercing bodies. Work is funded by the Office of Naval Research (grant N00014-11-1-0031) and the National Science Foundation's GRFP.

  13. The effect of magnetic field on nanofluids heat transfer through a uniformly heated horizontal tube (United States)

    Hatami, N.; Kazemnejad Banari, A.; Malekzadeh, A.; Pouranfard, A. R.


    In this study, the effects of magnetic field on forced convection heat transfer of Fe3O4-water nanofluid with laminar flow regime in a horizontal pipe under constant heat flux conditions were studied, experimentally. The convective heat transfer of magnetic fluid flow inside the heated pipe with uniform magnetic field was measured. Fe3O4 nanoparticles with diameters less than 100 nm dispersed in water with various volume concentrations are used as the test fluid. The effect of the external magnetic field (Ha = 33.4 ×10-4 to 136.6 ×10-4) and nanoparticle concentrations (φ = 0, 0.1, 0.5, 1%) on heat transfer characteristics were investigated. Results showed that by the presence of a magnetic field, increase in nanoparticle concentration caused reduction of convection heat transfer coefficient. In this condition, heat transfer decreased up to 25%. Where, in the absence of an external magnetic field, adding magnetic nanoparticles increased convection heat transfer more than 60%. It was observed that the Nusselt number decreased by increasing the Hartmann number at a specified concentration of magnetic nanofluids, that reduction about 25% in heat transfer rate could be found.

  14. Effect of Uniform and Non-uniform High-z Nanoparticles Distribution in Tumor Volume on Dose Enhancement Factor During 192Ir Brachytherapy

    Directory of Open Access Journals (Sweden)

    M Zabihzadeh


    Conclusion: increase of atomic number and concentrations of NPs enhance the absorbed dose due to increased possibility of photoelectric phenomena. Non-uniform distribution of NPs underestimated dose compared to uniform distribution; therefore, considering accurate NPs distribution inside the tumor volume is crucial to calculation of dose enhancement. Targeted labeling of NPs for the maximum absorption by tumor and for the minimal penetration into peripheral tissues has potential to increase radiation therapeutic ratio.

  15. Effects of process parameters on sheet resistance uniformity of fluorine-doped tin oxide thin films. (United States)

    Hudaya, Chairul; Park, Ji Hun; Lee, Joong Kee


    An alternative indium-free material for transparent conducting oxides of fluorine-doped tin oxide [FTO] thin films deposited on polyethylene terephthalate [PET] was prepared by electron cyclotron resonance - metal organic chemical vapor deposition [ECR-MOCVD]. One of the essential issues regarding metal oxide film deposition is the sheet resistance uniformity of the film. Variations in process parameters, in this case, working and bubbler pressures of ECR-MOCVD, can lead to a change in resistance uniformity. Both the optical transmittance and electrical resistance uniformity of FTO film-coated PET were investigated. The result shows that sheet resistance uniformity and the transmittance of the film are affected significantly by the changes in bubbler pressure but are less influenced by the working pressure of the ECR-MOCVD system.

  16. Effect of non-uniform magnetic field on crystal growth by floating-Zone method in microgravity

    Institute of Scientific and Technical Information of China (English)

    李凯; 胡文瑞


    The magnetic damping effect of the non-uniform magnetic field on the floating-zone crystal growth process in microgravity is studied by numerical simulation. The results show that the non-uni-form magnetic field with designed configuration can effectively reduce the flow near the free surface and then in the melt zone. At the same time, the designed magnetic field can improve the impurity concen-tration non-uniformity along the solidification interface. The primary principles of the magnetic field con-figuration design are also discussed.

  17. Effect of Uniformly and Nonuniformly Coated Al2O3 Nanoparticles over Glass Tube Heater on Pool Boiling

    Directory of Open Access Journals (Sweden)

    Nitin Doifode


    Full Text Available Effect of uniformly and nonuniformly coated Al2O3 nanoparticles over plain glass tube heater on pool boiling heat transfer was studied experimentally. A borosilicate glass tube coated with Al2O3 nanoparticle was used as test heater. The boiling behaviour was studied by using high speed camera. Result obtained for pool boiling shows enhancement in heat transfer for nanoparticle coated surface heater and compared with plain glass tube heater. Also heat transfer coefficient for nonuniformly coated nanoparticles was studied and compared with uniformly coated and plain glass tube. Coating effect of nanoparticles over glass tube increases its surface roughness and thereby creates more nucleation sites.

  18. II. Biological studies of radiation effects

    Energy Technology Data Exchange (ETDEWEB)

    Lawrence, J.H.


    With the completion of the 184 inch cyclotron in Berkeley and the successful construction of a deflector system, it was possible to bring the 190 Mev deuteron and the 380 Mev alpha beams out into the air and to begin a study of the effects of high-energy deuteron beams by direct irradiation of biological specimens. The direct biological use of deuteron beams was attempted earlier in Berkeley by Marshak, MacLeish, and Walker in 1940. These and other investigators have been aware for some time of the potential usefulness of high energy particle beams for radio-biological studies and their suitability for biological investigations. R.R. Wilson advanced the idea of using fast proton beams to deliver radiation and intervening tissues. R.E. Zirkle pointed out that such particle beams may be focused or screened until a cross-section of the beam is small enough to study effects of irradiation under the microscope on single cells or on parts of single cells. This article gives an overview of the radiological use of high energy deuteron beams, including the following topics: potential uses of high energy particle beams; experiments on the physical properties of the beam; lethal effect of the deuteron beam on mice.

  19. Dependence of information entropy of uniform Fermi systems on correlations and thermal effects (United States)

    Moustakidis, Ch. C.; Massen, S. E.


    The influence of correlations of uniform Fermi systems (nuclear matter, electron gas, and liquid He3 ) on Shannon’s information entropy, S , is studied. S is the sum of the information entropies in position and momentum spaces. It is found that, for three different Fermi systems with different particle interactions, the correlated part of S (Scor) depends on the correlation parameter of the systems or on the discontinuity gap of the momentum distribution through two parameter expressions. The values of the parameters characterize the strength of the correlations. A two parameter expression also holds between Scor and the mean kinetic energy (K) of the Fermi system. The study of thermal effects on the uncorrelated electron gas leads to a relation between the thermal part of S (Sthermal) and the fundamental quantities of temperature, thermodynamical entropy, and the mean kinetic energy. It is found that, in the case of low temperature limit, the expression connecting Sthermal with K is the same to the one which connects Scor with K . There are only some small differences on the values of the parameters. Thus, regardless of the reason (correlations or thermal) that changes K , S takes almost the same value.

  20. Effect of Non-Uniform Divertor Target Properties on Scrape-off Layer Plasma Equilibrium (United States)

    Subba, Fabio; Tskhakaya, David; Holzmueller-Steinacker, Ulrike; Schupfer, Nikolaus; Stanojevic, Mladen; Kuhn, Siegbert


    It is well known that plasma in contact with a solid wall develops a boundary layer, which typically consists of a thin Debye sheath adjacent to the wall and a more extended presheath providing the transition to the unperturbed plasma [1,2]. As the physical interaction of the plasma with the surrounding universe is mainly localized in this region, it may be expected that this boundary layer, which sensitively controls particle and energy fluxes to and from the plasma, plays an important role in determining the properties of the overall plasma equilibrium. On the other hand, it is generally assumed that the details of the adopted boundary-layer models do not influence dramatically the overall SOL behavior. However, little quantitative literature is actually available on the subject [3]. The purpose of this paper is to make a contribution towards clarifying this issue. In particular, we will use the B2.5 code [4] for studying the influence of non-uniformity of the effective secondary-electron emission coefficient (ESEEC) on the plasma parameters in the SOL.

  1. Uniform annealing effect of electron irradiation on ferromagnetic GaMnAs thin films (United States)

    Luo, Jia; Xiang, Gang; Gu, Gangxu; Zhang, Xi; Wang, Hailong; Zhao, Jianhua


    For more than a decade, researchers have been searching for means to improve the Curie temperature of ferromagnetic GaMnAs samples, among which post-growth annealing in furnace has been treated as the most important one. In this work, we demonstrate that the Curie temperature can be improved by electron irradiation for the first time. Different doses of electron irradiation (1 × 1014, 1 × 1015 and 1 × 1016 electrons/cm2) at 1.7 MeV were applied, the enhancement of magnetic and electrical properties of ferromagnetic GaMnAs films was experimentally confirmed by HR-XRD, SQUID and Magneto-transport measurements. Further SIMS characterizations and analyses reveal that electron irradiation causes bi-directional out-diffusion and redistribution of compensating Mn interstitials towards both the upper surface and the lower interface, a newly found uniform effect clearly different from that of conventional post-growth annealing. The technique of electron irradiation annealing may provide an alternative way to improve the properties of electronic and magnetic compounds such as GaMnAs films.

  2. [Biological effects of electromagnetic fields (author's transl)]. (United States)

    Bernhardt, J


    This résumé deals with thermal and nonthermal effects of electromagnetic fields on man. In consideration of two aspects a limitation is necessary. Firstly, there will be discussed only direct and immediate influences on biological cells and tissues, secondly, the treatment is limited to such phenomena, for which biophysical aproximations, based on experimental data, could be developed. Hazards for the human being may occur only by thermal effects within the microwave range. Regarding frequencies below approximately 30 kHz, excitation processes cannot be excluded in exceptional cases. Thermal effects are predominant, between 30 kHz and 100 kHz, before excitations can appear. Furthermore, by comparing the electrically and magnetically induced currents with the naturally flowing currents in man caused by the brain's and heart's electrical activity, a "lower boundaryline" was estimated. Regarding electric or magnetic field strengths undercutting this boundary-line, direct effects on the central nervous system may be excluded; other mechanisms should be responsible for demonstrated biological effects. The paper closes referring to some reports--presently discussed--on experimental findings of biological effects, which are observed as a result of the influence of electromagnetic fields of small field strengths.

  3. The effects of non-uniform flow velocity on vibrations of single-walled carbon nanotube conveying fluid

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghi-Goughari, Moslem [Shahid Bahonar University of Kerman, Kerman (Iran, Islamic Republic of); Hosseini, Mohammad [Sirjan University of Technology, Sirjan (Iran, Islamic Republic of)


    The vibrational behavior of a viscous nanoflow-conveying single-walled carbon nanotube (SWCNT) was investigated. The nonuniformity of the flow velocity distribution caused by the viscosity of fluid and the small-size effects on the flow field was considered. Euler-Bernoulli beam model was used to investigate flow-induced vibration of the nanotube, while the non-uniformity of the flow velocity and the small-size effects of the flow field were formulated through Knudsen number (Kn), as a discriminant parameter. For laminar flow in a circular nanotube, the momentum correction factor was developed as a function of Kn. For Kn = 0 (continuum flow), the momentum correction factor was found to be 1.33, which decreases by the increase in Kn may even reach near 1 for the transition flow regime. We observed that for passage of viscous flow through a nanotube with the non-uniform flow velocity, the critical continuum flow velocity for divergence decreased considerably as opposed to those for the uniform flow velocity, while by increasing Kn, the difference between the uniform and non-uniform flow models may be reduced. In the solution part, the differential transformation method (DTM) was used to solve the governing differential equations of motion.

  4. Effect of uniform versus expanding retrieval practice on the recall of physiology information. (United States)

    Dobson, John L


    The purpose of this study was to compare the retention of selected physiology concepts throughout 30 days of two different uniform schedules of retrieval and two different expanding schedules of retrieval. Participants (n = 250) first read and reread 30 immunology and reproductive physiology concepts and were then repeatedly assessed, without feedback, according to one of the following four randomly assigned schedules: 1) immediately after learning and again 9 and 19 days later [uniform (days 1, 10, and 20)]; 2) 7, 14, and 21 days after learning [uniform (days 8, 15, and 22)]; 3) immediately after learning and again 5 and 15 days later [expanding (days 1, 6, and 16)]; and 4) 1, 6, and 16 days after learning [expanding (days 2, 7, and 17)]. All participants completed a final assessment 29 days after learning the physiology concepts. Mean final assessment scores ± SE for the uniform (days 1, 10, and 20), uniform (days 8, 15, and 22), expanding (days 1, 6, and 16), and expanding (days 2, 7, and 17) groups were 36.15 ± 1.97, 32.31 ± 1.87, 45.80 ± 2.56, and 39.71 ± 2.48, respectively. There were no differences in final assessment scores between the two expanding retrieval groups, but expanding (days 1, 6, and 16) group scores were significantly higher than those in both uniform retrieval groups (ANOVA, F = 6.52, P = 0.00). Also, the combined mean of the two expanding retrieval conditions (42.57 ± 1.80) was significantly higher (F = 14.09, P = 0.00) than the combined mean of the two uniform retrieval conditions (34.10 ± 1.36). The results indicate that participants benefited more from expanding retrieval practice, particularly when the first assessment was administered immediately after learning.

  5. The Biological Effects of Bilirubin Photoisomers. (United States)

    Jasprova, Jana; Dal Ben, Matteo; Vianello, Eleonora; Goncharova, Iryna; Urbanova, Marie; Vyroubalova, Karolina; Gazzin, Silvia; Tiribelli, Claudio; Sticha, Martin; Cerna, Marcela; Vitek, Libor


    Although phototherapy was introduced as early as 1950's, the potential biological effects of bilirubin photoisomers (PI) generated during phototherapy remain unclear. The aim of our study was to isolate bilirubin PI in their pure forms and to assess their biological effects in vitro. The three major bilirubin PI (ZE- and EZ-bilirubin and Z-lumirubin) were prepared by photo-irradiation of unconjugated bilirubin. The individual photoproducts were chromatographically separated (TLC, HPLC), and their identities verified by mass spectrometry. The role of Z-lumirubin (the principle bilirubin PI) on the dissociation of bilirubin from albumin was tested by several methods: peroxidase, fluorescence quenching, and circular dichroism. The biological effects of major bilirubin PI (cell viability, expression of selected genes, cell cycle progression) were tested on the SH-SY5Y human neuroblastoma cell line. Lumirubin was found to have a binding site on human serum albumin, in the subdomain IB (or at a close distance to it); and thus, different from that of bilirubin. Its binding constant to albumin was much lower when compared with bilirubin, and lumirubin did not affect the level of unbound bilirubin (Bf). Compared to unconjugated bilirubin, bilirubin PI did not have any effect on either SH-SY5Y cell viability, the expression of genes involved in bilirubin metabolism or cell cycle progression, nor in modulation of the cell cycle phase. The principle bilirubin PI do not interfere with bilirubin albumin binding, and do not exert any toxic effect on human neuroblastoma cells.

  6. Mechanistic Effects of Calcitriol in Cancer Biology

    Directory of Open Access Journals (Sweden)

    Lorenza Díaz


    Full Text Available Besides its classical biological effects on calcium and phosphorus homeostasis, calcitriol, the active vitamin D metabolite, has a broad variety of actions including anticancer effects that are mediated either transcriptionally and/or via non-genomic pathways. In the context of cancer, calcitriol regulates the cell cycle, induces apoptosis, promotes cell differentiation and acts as anti-inflammatory factor within the tumor microenvironment. In this review, we address the different mechanisms of action involved in the antineoplastic effects of calcitriol.

  7. Educators' Perceptions of the Effects of School Uniforms on School Climate in a Selected Metropolitan Disciplinary Alternative Education Program (United States)

    Chime, Emmanuel Onoh


    The purpose of this study was to examine educators' perceptions regarding the effects of school uniforms on school climate in a selected metropolitan disciplinary alternative education program. More specifically, this study investigated the influence of the variables group status, gender, ethnicity, age and years of experience on the perceptions…

  8. Weakly nonlinear Bell-Plesset effects for a uniformly converging cylinder

    Energy Technology Data Exchange (ETDEWEB)

    Wang, L. F., E-mail:; Ye, W. H.; Liu, Jie; He, X. T. [Institute of Applied Physics and Computational Mathematics, Beijing 100094 (China); HEDPS, Center for Applied Physics and Technology, Peking University, Beijing 100871 (China); Wu, J. F.; Zhang, W. Y. [Institute of Applied Physics and Computational Mathematics, Beijing 100094 (China); Guo, H. Y. [Graduate School, China Academy of Engineering Physics, Beijing 100088 (China)


    In this research, a weakly nonlinear (WN) model has been developed considering the growth of a small perturbation on a cylindrical interface between two incompressible fluids which is subject to arbitrary radial motion. We derive evolution equations for the perturbation amplitude up to third order, which can depict the linear growth of the fundamental mode, the generation of the second and third harmonics, and the third-order (second-order) feedback to the fundamental mode (zero-order). WN solutions are obtained for a special uniformly convergent case. WN analyses are performed to address the dependence of interface profiles, amplitudes of inward-going and outward-going parts, and saturation amplitudes of linear growth of the fundamental mode on the Atwood number, the mode number (m), and the initial perturbation. The difference of WN evolution in cylindrical geometry from that in planar geometry is discussed in some detail. It is shown that interface profiles are determined mainly by the inward and outward motions rather than bubbles and spikes. The amplitudes of inward-going and outward-going parts are strongly dependent on the Atwood number and the initial perturbation. For low-mode perturbations, the linear growth of fundamental mode cannot be saturated by the third-order feedback. For fixed Atwood numbers and initial perturbations, the linear growth of fundamental mode can be saturated with increasing m. The saturation amplitude of linear growth of the fundamental mode is typically 0.2λ–0.6λ for m < 100, with λ being the perturbation wavelength. Thus, it should be included in applications where Bell-Plesset [G. I. Bell, Los Alamos Scientific Laboratory Report No. LA-1321, 1951; M. S. Plesset, J. Appl. Phys. 25, 96 (1954)] converging geometry effects play a pivotal role, such as inertial confinement fusion implosions.

  9. Effect of Uniform versus Expanding Retrieval Practice on the Recall of Physiology Information (United States)

    Dobson, John L.


    The purpose of this study was to compare the retention of selected physiology concepts throughout 30 days of two different uniform schedules of retrieval and two different expanding schedules of retrieval. Participants (n = 250) first read and reread 30 immunology and reproductive physiology concepts and were then repeatedly assessed, without…

  10. Effect of non-uniform mean flow field on acoustic propagation problems in computational aeroacoustics

    DEFF Research Database (Denmark)

    Si, Haiqing; Shen, Wen Zhong; Zhu, Wei Jun


    Acoustic propagation in the presence of a non-uniform mean flow is studied numerically by using two different acoustic propagating models, which solve linearized Euler equations (LEE) and acoustic perturbation equations (APE). As noise induced by turbulent flows often propagates from near field t...

  11. Uniform stable-isotope labeling in mammalian cells: formulation of a cost-effective culture medium

    NARCIS (Netherlands)

    Egorova-Zachernyuk, T.A.; Bosman, G.J.C.G.M.; Grip, W.J. de


    Uniform stable-isotope labeling of mammalian cells is achieved via a novel formulation of a serum-free cell culture medium that is based on stable-isotope-labeled autolysates and lipid extracts of various microbiological origin. Yeast autolysates allow complete replacement of individual amino acids

  12. The Effect of School Uniform on Incidental Physical Activity among 10-Year-Old Children (United States)

    Norrish, Hannah; Farringdon, Fiona; Bulsara, Max; Hands, Beth


    The school setting provides a unique opportunity to promote physical activity in children by ensuring adequate time, appropriate facilities and education guidance is offered. However school uniform design could also limit physical activity. A repeated measures crossover design was used to compare school recess and lunchtime physical activity over…

  13. The Biological Effects of Bilirubin Photoisomers.

    Directory of Open Access Journals (Sweden)

    Jana Jasprova

    Full Text Available Although phototherapy was introduced as early as 1950's, the potential biological effects of bilirubin photoisomers (PI generated during phototherapy remain unclear. The aim of our study was to isolate bilirubin PI in their pure forms and to assess their biological effects in vitro. The three major bilirubin PI (ZE- and EZ-bilirubin and Z-lumirubin were prepared by photo-irradiation of unconjugated bilirubin. The individual photoproducts were chromatographically separated (TLC, HPLC, and their identities verified by mass spectrometry. The role of Z-lumirubin (the principle bilirubin PI on the dissociation of bilirubin from albumin was tested by several methods: peroxidase, fluorescence quenching, and circular dichroism. The biological effects of major bilirubin PI (cell viability, expression of selected genes, cell cycle progression were tested on the SH-SY5Y human neuroblastoma cell line. Lumirubin was found to have a binding site on human serum albumin, in the subdomain IB (or at a close distance to it; and thus, different from that of bilirubin. Its binding constant to albumin was much lower when compared with bilirubin, and lumirubin did not affect the level of unbound bilirubin (Bf. Compared to unconjugated bilirubin, bilirubin PI did not have any effect on either SH-SY5Y cell viability, the expression of genes involved in bilirubin metabolism or cell cycle progression, nor in modulation of the cell cycle phase. The principle bilirubin PI do not interfere with bilirubin albumin binding, and do not exert any toxic effect on human neuroblastoma cells.

  14. Method for photo-altering a biological system to improve biological effect (United States)

    Hill, Richard A.; Doiron, Daniel R.; Crean, David H.


    Photodynamic therapy is a new adjunctive therapy for filtration surgery that does not use chemotherapy agents or radiation, but uses pharmacologically-active sensitizing compounds to produce a titratable, localized, transient, post operative avascular conjunctiva. A photosensitizing agent in a biological system is selectively activated by delivering the photosensitive agent to the biological system and laser activating only a spatially selected portion of the delivered photosensitive agent. The activated portion of the photosensitive agent reacts with the biological system to obtain a predetermined biological effect. As a result, an improved spatial disposition and effectuation of the biological effect by the photosensitive agent in the biological system is achieved.

  15. Isoflavones: estrogenic activity, biological effect and bioavailability. (United States)

    Vitale, Daniela Cristina; Piazza, Cateno; Melilli, Barbara; Drago, Filippo; Salomone, Salvatore


    Isoflavones are phytoestrogens with potent estrogenic activity; genistein, daidzein and glycitein are the most active isoflavones found in soy beans. Phytoestrogens have similarity in structure with the human female hormone 17-β-estradiol, which can bind to both alpha and beta estrogen receptors, and mimic the action of estrogens on target organs, thereby exerting many health benefits when used in some hormone-dependent diseases. Numerous clinical studies claim benefits of genistein and daidzein in chemoprevention of breast and prostate cancer, cardiovascular disease and osteoporosis as well as in relieving postmenopausal symptoms. The ability of isoflavones to prevent cancer and other chronic diseases largely depends on pharmacokinetic properties of these compounds, in particular absorption and distribution to the target tissue. The chemical form in which isoflavones occur is important because it influences their bioavailability and, therefore, their biological activity. Glucose-conjugated isoflavones are highly polar, water-soluble compounds. They are hardly absorbed by the intestinal epithelium and have weaker biological activities than the corresponding aglycone. Different microbial families of colon can transform glycosylated isoflavones into aglycones. Clinical studies show important differences between the aglycone and conjugated forms of genistein and daidzein. The evaluation of isoflavone metabolism and bioavailability is crucial to understanding their biological effects. Lipid-based formulations such as drug incorporation into oils, emulsions and self-microemulsifying formulations have been introduced to increase bioavailability. Complexation with cyclodextrin also represent a valid method to improve the physicochemical characteristics of these substances in order to be absorbed and distributed to target tissues. We review and discuss pharmacokinetic issues that critically influence the biological activity of isoflavones.

  16. Vacuum Quantum Effects for Parallel Plates Moving by Uniform Acceleration in Static de Sitter Space

    CERN Document Server

    Setare, M R


    The Casimir forces on two parallel plates moving by uniform proper acceleration in static de Sitter background due to conformally coupled massless scalar field satisfying Dirichlet boundary conditions on the plates is investigated. Static de Sitter space is conformally related to the Rindler space, as a result we can obtain vacuum expectation values of energy-momentum tensor for conformally invariant field in static de Sitter space from the corresponding Rindler counterpart by the conformal transformation.

  17. Effects of process parameters on sheet resistance uniformity of fluorine-doped tin oxide thin films



    An alternative indium-free material for transparent conducting oxides of fluorine-doped tin oxide [FTO] thin films deposited on polyethylene terephthalate [PET] was prepared by electron cyclotron resonance - metal organic chemical vapor deposition [ECR-MOCVD]. One of the essential issues regarding metal oxide film deposition is the sheet resistance uniformity of the film. Variations in process parameters, in this case, working and bubbler pressures of ECR-MOCVD, can lead to a change in resist...

  18. Analysis of single blow effectiveness in non-uniform parallel plate regenerators

    DEFF Research Database (Denmark)

    Jensen, Jesper Buch; Bahl, Christian Robert Haffenden; Engelbrecht, Kurt;


    Non-uniform distributions of plate spacings in parallel plate regenerators have been found to induce loss of performance. In this paper, it has been investigated how variations of three geometric parameters (the aspect ratio, the porosity, and the standard deviation of the plate spacing) affects...... this loss in a single blow model of a parallel-plate regenerator. Simple analytical functions for the magnitude and the time scale of the reduction of performance are presented and compared to numerical results....

  19. Porogen effects in synthesis of uniform micrometer-sized poly(divinylbenzene) microspheres with high surface areas. (United States)

    Hao, Dong-xia; Gong, Fang-ling; Wei, Wei; Hu, Guo-hua; Ma, Guang-hui; Su, Zhi-guo


    A new method of synthesizing uniform poly(divinylbenzene) (polyDVB) microspheres with high specific surface areas was designed by combining Shirasu porous glass (SPG) membrane emulsification, suspension polymerization, and post-crosslinking techniques. It was shown that the physicochemical properties of porogens have a great influence on the size distribution and porous features of microspheres. The low aqueous solubility of porogen facilitated preparation of uniform emulsions and microspheres, and high aqueous solubility led to polydispersed emulsions and poor microsphere yields. Such aqueous solubility effects can be tailored by adding a low molecular weight polystyrene (LPST) as costabilizer in porogen, thus improving the uniformity of microspheres. Moreover, different affinities of porogens for copolymers demonstrate various contributions to specific surface areas of microspheres in suspension polymerization especially post-crosslinking. Solvating porogen requires a much higher addition than nonsolvating porogen to obtain equal specific surface areas in polymerization, but has more potential to enhance the specific surface area in post-crosslinking. Two kinds of uniform microspheres were obtained with high specific surface areas, up to 706.6 m2/g by heptane and 937.5 m2/g by toluene.

  20. Effectiveness of a newly designed construction uniform for heat strain attenuation in a hot and humid environment. (United States)

    Yi, Wen; Chan, Albert P C; Wong, Francis K W; Wong, Del P


    This study aims to evaluate the effectiveness of a newly designed construction uniform in combating heat stress. Ten male volunteers performed treadmill running in a climatic chamber maintained at 34.5 °C temperature, 75% relative humidity, 0.3 m/s air velocity, and solar radiation of 450 W/m(2) that simulates typical summer working environment of construction sites in Hong Kong. The participants were tested while wearing two kinds of construction uniforms: a commonly worn uniform A, or a newly designed uniform B. It was found during exercise that Tc (38.34 ± 0.14 vs 38.45 ± 0.11 °C, p = 0.03), Tsk (36.01 ± 0.36 vs 36.27 ± 0.34 °C, p = 0.03), HR (162.7 ± 10.1 vs 172.5 ± 9.2 bpm, p environment.

  1. Use of insecticide-treated school uniforms for prevention of dengue in schoolchildren: a cost-effectiveness analysis.

    Directory of Open Access Journals (Sweden)

    Yesim Tozan

    Full Text Available BACKGROUND: Dengue-related illness is a leading cause of hospitalization and death, particularly among children. Practical, acceptable and affordable measures are urgently needed to protect this age group. Schools where children spend most of their day is proposed as an ideal setting to implement preventive strategies against day-biting Aedes mosquitoes. The use of insecticide-treated school uniforms is a promising strategy currently under investigation. METHODS: Using a decision-analytic model, we evaluated the cost-effectiveness of the use of insecticide-treated school uniforms for prevention of dengue, compared with a "do-nothing" alternative, in schoolchildren from the societal perspective. We explored how the potential economic value of the intervention varied under various scenarios of intervention effectiveness and cost, as well as dengue infection risk in school-aged children, using data specific to Thailand. RESULTS: At an average dengue incidence rate of 5.8% per year in school-aged children, the intervention was cost-effective (ICER≤$16,440 in a variety of scenarios when the intervention cost per child was $5.3 or less and the intervention effectiveness was 50% or higher. In fact, the intervention was cost saving (ICER$16,440. CONCLUSIONS: Our results present the potential economic value of the use of insecticide-treated uniforms for prevention of dengue in schoolchildren in a typical dengue endemic setting and highlight the urgent need for additional research on this intervention.

  2. Uniformity and continuity of effective strain in AZ91D processed by multi-pass equal channel angular extrusion

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiao-hua; LUO Shou-jing; DU Zhi-ming


    AZ91D magnesium alloy was processed by equal channel angular extrusion(ECAE). The influence of extrusion temperature, extrusion pass and extrusion route on the ultimate strength of the extruded billet was analyzed. The process of multi-pass extrusion was simulated with the method of finite element analysis, and the continuity and uniformity of effective strain in multi-pass extrusion were investigated. The results show that extrusion pass plays the most important role in improving the ultimate strength of AZ91D magnesium alloy, the extrusion route is the second, and the extrusion temperature is the last. From the numerical simulation, there exists the continuity of the accumulated deformation in multi-pass extrusion and the effective strain increases linearly. The tendency of the strain uniformity is different in multi-pass extrusion with extrusion routes. The results of experiment agree with those of numerical simulation.


    DEFF Research Database (Denmark)

    Sleep, Norman H.; Bird, Dennis K.; Rosing, Minik T.


    Detection of antineutrinos from U and Th series decay within the Earth (geoneutrinos) constrains the absolute abundance of these elements. Marine detectors will measure the ratio over the mantle beneath the site and provide spatial averaging. The measured mantle Th/U may well be significantly below...... its bulk earth value of similar to 4; Pb isotope measurements on mantle-derived rocks yield low Th/U values, effectively averaged over geological time. The physics of the modern biological process is complicated, but the net effect is that much of the U in the mantle comes from subducted marine......, these elements behave similarly in the absence of life, where the elements occur as U(IV) and Th(IV), which do not significantly fractionate during igneous processes. Neither do they fractionate during weathering, as they are essentially insoluble in water in surface environments. Th(IV) and U(IV) remain...

  4. Effect of spray process conditions on uniformity of carbon nanotube thin films. (United States)

    Du Choi, Soon; Kim, Duckjong; Kang, Yong-Pil; Jang, Dong Hwan


    Industrial use of carbon nanotube (CNT) films is increasing rapidly due to their good physical properties and high economic feasibility. Spray coating process is one of feasible approaches for large area CNT films. Uniform spray coating is an important issue in applications requiring large area conductive films. In the present work, we developed a numerical model for the prediction of CNT deposition thickness distribution in the spray process and validated the numerical work by using experimental data obtained in this study. We investigated the deposition thickness distributions according to various process parameters by using the numerical model. We found that the pitch of the nozzle path is a key parameter affecting the deposition thickness uniformity and that there is optimal pitch value for unfirom and productive coating. We also discussed future research direction for improved numerical simulation tool. Since the present numerical model is also applicable to simulation of spray process on curvy substrate, the numerical model could be an imporatnt step toward a powerful simulation tool for design and optimization of the nanomaterial spray process.

  5. Effects of shape and size of agar gels on heating uniformity during pulsed microwave treatment. (United States)

    Soto-Reyes, Nohemí; Temis-Pérez, Ana L; López-Malo, Aurelio; Rojas-Laguna, Roberto; Sosa-Morales, María Elena


    Model gel systems with different shape (sphere, cylinder, and slab) and size (180 and 290 g) were prepared with agar (5%) and sucrose (5%). Dielectric constant (ε'), loss factor (ε"), thermophysical properties, and temperature distribution of the model system were measured. Each agar model system was immersed and suspended in water, and then, heated in a microwave oven with intermittent heating until the core temperature reached 50 °C. The ε' and ε" of agar gels decreased when frequency increased. The density and thermal conductivity values of the agar gels were 1033 kg/m(3) and 0.55 W/m °C, respectively. The temperature distribution of sphere, cylinder, and slab was different when similar power doses were applied. The slab reached 50 °C in less time (10 min) and showed a more uniform heating than spheres and cylinders in both sizes. Agar model systems of 180 g heated faster than those of 290 g. The coldest point was the center of the model systems in all studied cases. Shape and size are critical food factors that affect the heating uniformity during microwave heating processes.

  6. Effects of magnetic field on the interaction between terahertz wave and non-uniform plasma slab

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Yuan; Han, YiPing; Guo, LiXin [School of physics and optoelectronic engineering, Xidian University, Xi' an 710071 (China); Ai, Xia [National Key Laboratory of Science and Technology on Test Physics and Numerical Mathematical, Beijing 100076 (China)


    In this paper, the interaction between terahertz electromagnetic wave and a non-uniform magnetized plasma slab is investigated. Different from most of the published literatures, the plasma employed in this work is inhomogeneous in both collision frequency and electron density. Profiles are introduced to describe the non-uniformity of the plasma slab. At the same time, magnetic field is applied to the background of the plasma slab. It came out with an interesting phenomenon that there would be a valley in the absorption band as the plasma's electromagnetic characteristic is affected by the magnetic field. In addition, the valley located just near the middle of the absorption peak. The cause of the valley's appearance is inferred in this paper. And the influences of the variables, such as magnetic field strength, electron density, and collision frequency, are discussed in detail. The objective of this work is also pointed out, such as the applications in flight communication, stealth, emissivity, plasma diagnose, and other areas of plasma.

  7. Investigation of Furnace Uniformity and its Effect on High-Temperature Fixed-Point Performance (United States)

    Khlevnoy, B.; Sakharov, M.; Ogarev, S.; Sapritsky, V.; Yamada, Y.; Anhalt, K.


    A large-area furnace BB3500YY was designed and built at the VNIIOFI as a furnace for high-temperature metal (carbide)-carbon (M(C)-C) eutectic fixed points and was then investigated at the NMIJ. The dependence of the temperature uniformity of the furnace on various heater and cell holder arrangements was investigated. After making some improvements, the temperature of the central part of the furnace was uniform to within 2K over a length of 40 mm—the length of the fixed-point cell—at a temperature of 2,500°C. With this furnace, the melting plateaux of Re-C and TiC-C were shown to be better than those observed in other furnaces. For instance, a Re-C cell showed melting plateaux with a 0.1K melting range and a duration of about 40 min. Furthermore, to verify the capability of the furnace to fill cells, one Re-C and one TiC-C cell were made using the BB3500YY. The cells were then compared to a Re-C cell made in a Nagano furnace and a TiC-C cell filled in a BB3200pg furnace. The agreement in plateau shapes demonstrates the capability of the BB3500YY furnace to also function as a filling furnace.

  8. The effect of non-uniform attenuation compensation on myocardial SPECT defect analysis

    Energy Technology Data Exchange (ETDEWEB)

    Manglos, S.H.; Thomas, F.D.; Hellwig, B.J. (State Univ. of New York, Syracuse, NY (United States). Dept. of Radiology)


    In SPECT myocardial imaging, the measurement of defect size helps to evaluate the existence and severity of suspected cardiovascular disease. To determine whether non-uniform attenuation and its compensation alter the apparent defect size, and thus potentially impact clinical evaluations, phantom studies were performed with defects in a ''myocardium''. Non-uniform attenuation compensation was performed with weighted backprojection and a cone-beam CT attenuation map. Polar maps with defects were compared to maps without defects but otherwise identically acquired and processed. Attenuation compensation generally altered the defect size by no more than 10%, except that (i) a truncated attenuation map altered the size of some defects, and (ii) the size was increased when the polar map with a defect was more attenuated than the defect-free polar map (simulating the comparison of a large patient to a smaller one). This increase was removed by attenuation, which also produced much more circularly symmetric polar maps. (Author).

  9. Effect of gold wire bonding process on angular correlated color temperature uniformity of white light-emitting diode. (United States)

    Wu, Bulong; Luo, Xiaobing; Zheng, Huai; Liu, Sheng


    Gold wire bonding is an important packaging process of lighting emitting diode (LED). In this work, we studied the effect of gold wire bonding on the angular uniformity of correlated color temperature (CCT) in white LEDs whose phosphor layers were coated by freely dispersed coating process. Experimental study indicated that different gold wire bonding impacts the geometry of phosphor layer, and it results in different fluctuation trends of angular CCT at different spatial planes in one LED sample. It also results in various fluctuating amplitudes of angular CCT distributions at the same spatial plane for samples with different wire bonding angles. The gold wire bonding process has important impact on angular uniformity of CCT in LED package.

  10. Effects of Process Parameters on Deformation and Temperature Uniformity of Forged Ti-6Al-4V Turbine Blade (United States)

    Luo, Shiyuan; Zhu, Dahu; Hua, Lin; Qian, Dongsheng; Yan, Sijie; Yu, Fengping


    This work is motivated by the frequent occurrence of macro- and microdefects within forged Ti-6Al-4V turbine blades due to the severely nonuniform strain and temperature distributions. To overcome the problem of nonuniformity during the blade forging operation, firstly, a 2D coupled thermo-mechanical finite element approach using the strain-compensated Arrhenius-type constitutive model is employed to simulate the real movements and processing conditions, and its reliability is verified experimentally. Secondly, two evaluation indexes, standard deviation of equivalent plastic strain and standard deviation of temperature, are proposed to evaluate the uniformity characteristics within the forged blade, and the effects of four process parameters including the forging velocity, friction factor, initial workpiece temperature and dwell time on the uniformity of strain and temperature distributions are carefully studied. Finally, the numerically optimized combination of process parameters is validated by the application in a practical process. The parametric study reveals that a reasonable combination of process parameters considering the flow resistance, flow localization and the effects of deformation and friction heating is crucial for the titanium alloy blade forging with uniformity. This work can provide a significant guidance for the design and optimization of blade forging processes.

  11. Biological effects of space radiation and development of effective countermeasures (United States)

    Kennedy, Ann R.


    As part of a program to assess the adverse biological effects expected from astronauts' exposure to space radiation, numerous different biological effects relating to astronauts' health have been evaluated. There has been major focus recently on the assessment of risks related to exposure to solar particle event (SPE) radiation. The effects related to various types of space radiation exposure that have been evaluated are: gene expression changes (primarily associated with programmed cell death and extracellular matrix (ECM) remodeling), oxidative stress, gastrointestinal tract bacterial translocation and immune system activation, peripheral hematopoietic cell counts, emesis, blood coagulation, skin, behavior/fatigue (including social exploration, submaximal exercise treadmill and spontaneous locomotor activity), heart functions, alterations in biological endpoints related to astronauts' vision problems (lumbar puncture/intracranial pressure, ocular ultrasound and histopathology studies), and survival, as well as long-term effects such as cancer and cataract development. A number of different countermeasures have been identified that can potentially mitigate or prevent the adverse biological effects resulting from exposure to space radiation.

  12. The Effect of Vacuum Fluctuations on Quantum Metrology for a Uniformly Accelerated Atom (United States)

    Jin, Yao


    We studied, in the framework of open quantum systems, the dynamics of the quantum Fisher information of the parameters of the initial atomic state and atomic transition frequency for a uniformly accelerated polarizable two-level atom coupled in the multipolar scheme to a bath of fluctuating vacuum electromagnetic fields in Minkowski space-time. Our results show that the vacuum fluctuations in Minkowski space-time always make the quantum Fisher information decay, thus degrade the precision of the parameter estimation. The acceleration of the atom makes the quantum Fisher information of initial parameters of atomic state decay faster than those in case with static atom in Minkowski vacuum and even those in case with static atom in Minkowski thermal bath with corresponding Unruh temperature. The maxima of quantum Fisher information of atomic frequency and the optimal measurement time are shown to be smaller than those in the static atom in vacuum case as well as those in the corresponding thermal case.

  13. An efficient plate heater with uniform surface temperature engineered with effective thermal materials

    CERN Document Server

    Liu, Yichao; He, Sailing; Ma, Yungui


    Extended from its electromagnetic counterpart, transformation thermodynamics applied to thermal conduction equations can map a virtual geometry into a physical thermal medium, realizing the manipulation of heat flux with almost arbitrarily desired diffusion paths, which provides unprecedented opportunities to create thermal devices unconceivable or deemed impossible before. In this work we employ this technique to design an efficient plate heater that can transiently achieve a large surface of uniform temperature powered by a small thermal source. As opposed to the traditional approach of relying on the deployment of a resistor network, our approach fully takes advantage of an advanced functional material system to guide the heat flux to achieve the desired temperature heating profile. A different set of material parameters for the transformed device has been developed, offering the parametric freedom for practical applications. As a proof of concept, the proposed devices are implemented with engineered therm...

  14. Effect of the Pd-Au thin film thickness uniformity on the performance of an optical fiber hydrogen sensor

    Energy Technology Data Exchange (ETDEWEB)

    Luna-Moreno, Donato [Centro de Investigaciones en Optica A. C., Loma del Bosque 115, Leon GTO, 37150 (Mexico)]. E-mail:; Monzon-Hernandez, David [Centro de Investigaciones en Optica A. C., Loma del Bosque 115, Leon GTO, 37150 (Mexico)


    Thin alloy film of Pd and Au, formed by simultaneous electron-beam and thermal evaporation techniques, respectively, is used in the design of an optical fiber hydrogen sensor. The sensor consists of a multimode fiber (MMF) in which a short section of single mode fiber (SMF), coated with the Pd-Au thin film, is inserted. Due to core diameter mismatch, the SMF cladding guides light, allowing the interaction between the sensing layer and the guided light. When the sensor is exposed to hydrogen, the Pd-Au layer refractive index diminishes and causes attenuation changes on the transmitted light. Several samples with different layer thickness uniformity were fabricated and tested in a very simple experimental set-up. We have observed that the sensor signal change is dependant on layer thickness uniformity, since the effective interaction length between the evanescent field and the sensing layer is increased. By contrast, such uniformity practically has no influence on the time response of the sensor. The resulting Pd-Au film can detect 4% hydrogen with a response time of 15 s.

  15. Analysis of hysteresis effect on the vibration motion of a bimodal non-uniform micro-cantilever using MCS theory (United States)

    Korayem, M. H.; Korayem, A. H.; Hosseini Hashemi, Sh.


    Nowadays, to enhance the performance of atomic force microscopy (AFM) micro-cantilevers (MCs) during imaging, reduce costs and increase the surface topography precision, advanced MCs equipped with piezoelectric layers are utilized. Using the modified couple stress (MCS) theory not only makes the modeling more exhaustive, but also increases the accuracy of prediction of the vibration behavior of the system. In this paper, Hamilton's principle by consideration of the MCS theory has been used to extract the equations. In addition, to discretize the equations, differential quadrature method has been adopted. Analysis of the hysteresis effect on the vibration behavior of the AFM MC is of significant importance. Thus, to model the hysteresis effect, Bouc-Wen method, which is solved simultaneously with the vibration equations of non-uniform Timoshenko beam, has been utilized. Furthermore, a bimodal excitation of the MC has been considered. The results reveal that the hysteresis effect appears as a phase difference in the time response. Finally, the effect of the geometric parameters on the vibration frequency of the system which is excited by combination of the first two vibration modes of the non-uniform piezoelectric MC has been examined. The results indicate the considerable effect of the MC length in comparison with other geometric parameters such as the MC width and thickness.

  16. The biologically effective dose in inhalation nanotoxicology. (United States)

    Donaldson, Ken; Schinwald, Anja; Murphy, Fiona; Cho, Wan-Seob; Duffin, Rodger; Tran, Lang; Poland, Craig


    In all branches of toxicology, the biologically effective dose (BED) is the fraction of the total dose of a toxin that actually drives any toxic effect. Knowledge of the BED has a number of applications including in building structure-activity relationships, the selection of metrics, the design of safe particles, and the determination of when a nanoparticle (NP) can be considered to be "new" for regulatory purposes. In particle toxicology, we define the BED as "the entity within any dose of particles in tissue that drives a critical pathophysiogically relevant form of toxicity (e.g., oxidative stress, inflammation, genotoxicity, or proliferation) or a process that leads to it." In conventional chemical toxicology, researchers generally use the mass as the metric to describe dose (such as mass per unit tissue or cells in culture) because of its convenience. Concentration, calculated from mass, may also figure in any description of dose. In the case of a nanoparticle dose, researchers use either the mass or the surface area. The mass of nanoparticles is not the only driver of their activity: the surfaces of insoluble particles interact with biological systems, and soluble nanoparticles can release factors that interact with these systems. Nanoparticle shape can modify activity. In this Account, we describe the current knowledge of the BED as it pertains to different NP types. Soluble toxins released by NPs represent one potential indicator of BED for wholly or partially soluble NPs composed of copper or zinc. Rapid dissolution of these NPs into their toxic ions in the acidic environment of the macrophage phagolysosome causes those ions to accumulate, which leads to lysosome destabilization and inflammation. In contrast, soluble NPs that release low toxicity ions, such as magnesium oxide NPs, are not inflammogenic. For insoluble NPs, ζ potential can serve as a BED measurement because the exposure of the particle surface to the acidic milieu of the phagolysosome and

  17. Cell Biology of Thiazide Bone Effects (United States)

    Gamba, Gerardo; Riccardi, Daniela


    The thiazide-sensitive Na+:Cl- cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian kidney. The activity of NCC is not only related to salt metabolism, but also to calcium and magnesium homeostasis due to the inverse relationship between NCC activity and calcium reabsorption. Hence, the thiazide-type diuretics that specifically block NCC have been used for years, not only for treatment of hypertension and edematous disease, but also for the management of renal stone disease. Epidemiological studies have shown that chronic thiazide treatment is associated with higher bone mineral density and reduced risk of bone fractures, which can only partly be explained in terms of their effects on the kidney. In this regard, we have recently shown that NCC is expressed in bone cells and that inhibition of NCC in bone, either by thiazides or by reduction of NCC protein with specific siRNA, is associated with increased mineralization in vitro. These observations open a field of study to begin to understand the cell biology of the beneficial effects of thiazides in bone.

  18. Statistical Test for Bivariate Uniformity

    Directory of Open Access Journals (Sweden)

    Zhenmin Chen


    Full Text Available The purpose of the multidimension uniformity test is to check whether the underlying probability distribution of a multidimensional population differs from the multidimensional uniform distribution. The multidimensional uniformity test has applications in various fields such as biology, astronomy, and computer science. Such a test, however, has received less attention in the literature compared with the univariate case. A new test statistic for checking multidimensional uniformity is proposed in this paper. Some important properties of the proposed test statistic are discussed. As a special case, the bivariate statistic test is discussed in detail in this paper. The Monte Carlo simulation is used to compare the power of the newly proposed test with the distance-to-boundary test, which is a recently published statistical test for multidimensional uniformity. It has been shown that the test proposed in this paper is more powerful than the distance-to-boundary test in some cases.

  19. Chemical Reaction Effects on MHD Flow Past an Impulsively Started Isothermal Vertical Plate with Uniform Mass Diffusion

    Directory of Open Access Journals (Sweden)

    Chandrakala P.


    Full Text Available A numerical technique is employed to derive a solution to the transient natural convection flow of an incompressible viscous fluid past an impulsively started infinite isothermal vertical plate with uniform mass diffusion in the presence of a magnetic field and homogeneous chemical reaction of first order. The governing equations are solved using implicit finite-difference method. The effects of velocity, temperature and concentration for different parameters such as the magnetic field parameter, chemical reaction parameter, Prandtl number, Schmidt number, thermal Grashof number and mass Grashof number are studied. It is observed that the fluid velocity decreases with increasing the chemical reaction parameter and the magnetic field parameter.

  20. What Makes Biology Learning Difficult and Effective: Students' Views (United States)

    Cimer, Atilla


    The present study aims to determine the biological topics that students have difficulties learning, the reasons why secondary school students have difficulties in learning biology, and ways to improve the effectiveness of students' biology learning. For these purposes, a self-administered questionnaire including three open-ended questions was…

  1. The un-uniform observatories location effect in the Dst index (United States)

    Wu, Y.


    The Dst index is a major planetary magnetic activity index proposed by Sugiura in 1964, which is designed to depict the temporal development of the magnetic storm and the intensity of the ring current system flowing in the equatorial plane of the magnetosphere at 3 to 8 Earth radii. It is an hourly index derived from the average value of the horizontal component of the geomagnetic field at four low latitudinal observatories (namely, HER, HON, KAK and SJG). For a long time, the Dst index is greatly doubted. Researchers have pointed out that a great proportion of the Dst index is originated from the Substorm Wedge current system, the Cross-tail current and the Partial ring current system [Turner et al., 2000; Liemohn et al., 2001; Ohtani et al., 2001; Rostoker, 2000; Friedrich et al., 1999; Maltsev, 2003; Huang, 2004; Hakkinen et al., 2002]. The ring current system and its disturbed storm-time field (Dst field) take on an enhanced dawn-dusk asymmetry during disturbed time. Therefore, the influence of the non-uniform location of four observatories of the Dst index will enhance. The purpose of this paper is to study the influence of the observatories' location on the Dst index. The hourly data of the horizontal component of the geomagnetic field in the observatories in geomagnetic latitude between 45°S and -45°N is used, to derive the local-time distribution model of the Dst field by the method of Nature Orthogonal Component and Cubic Polynomial Fitting. Results suggest that the maximum difference to the LT-model with four Dst index stations is about 5% lowness on 16UTmp, 3% highness on 05UTmp, and the minimum difference is around 11UTmp (UTmp corresponds to the universal time of the minimum of the Dst index). It proves some certain extent efficiency afforded by adding observatories in the SYM index.

  2. Biologically based multistage modeling of radiation effects

    Energy Technology Data Exchange (ETDEWEB)

    William Hazelton; Suresh Moolgavkar; E. Georg Luebeck


    This past year we have made substantial progress in modeling the contribution of homeostatic regulation to low-dose radiation effects and carcinogenesis. We have worked to refine and apply our multistage carcinogenesis models to explicitly incorporate cell cycle states, simple and complex damage, checkpoint delay, slow and fast repair, differentiation, and apoptosis to study the effects of low-dose ionizing radiation in mouse intestinal crypts, as well as in other tissues. We have one paper accepted for publication in ''Advances in Space Research'', and another manuscript in preparation describing this work. I also wrote a chapter describing our combined cell-cycle and multistage carcinogenesis model that will be published in a book on stochastic carcinogenesis models edited by Wei-Yuan Tan. In addition, we organized and held a workshop on ''Biologically Based Modeling of Human Health Effects of Low dose Ionizing Radiation'', July 28-29, 2005 at Fred Hutchinson Cancer Research Center in Seattle, Washington. We had over 20 participants, including Mary Helen Barcellos-Hoff as keynote speaker, talks by most of the low-dose modelers in the DOE low-dose program, experimentalists including Les Redpath (and Mary Helen), Noelle Metting from DOE, and Tony Brooks. It appears that homeostatic regulation may be central to understanding low-dose radiation phenomena. The primary effects of ionizing radiation (IR) are cell killing, delayed cell cycling, and induction of mutations. However, homeostatic regulation causes cells that are killed or damaged by IR to eventually be replaced. Cells with an initiating mutation may have a replacement advantage, leading to clonal expansion of these initiated cells. Thus we have focused particularly on modeling effects that disturb homeostatic regulation as early steps in the carcinogenic process. There are two primary considerations that support our focus on homeostatic regulation. First, a number of

  3. Biological Effects on the Source of Geoneutrinos (United States)

    Sleep, Norman H.; Bird, Dennis K.; Rosing, Minik T.


    Detection of antineutrinos from U and Th series decay within the Earth (geoneutrinos) constrains the absolute abundance of these elements. Marine detectors will measure the ratio over the mantle beneath the site and provide spatial averaging. The measured mantle Th/U may well be significantly below its bulk earth value of 4; Pb isotope measurements on mantle-derived rocks yield low Th/U values, effectively averaged over geological time. The physics of the modern biological process is complicated, but the net effect is that much of the U in the mantle comes from subducted marine sediments and subducted upper oceanic crust. That is, U subducts preferentially relative to Th. Oxygen ultimately from photosynthesis oxidizes U(IV) to U(VI), which is soluble during weathering and sediment transport. Dissolved U(VI) reacts with FeO in the oceanic crust and organic carbon within sediments to become immobile U(IV). These deep marine rocks are preferentially subducted relative to Th(IV)-bearing continental margin rocks. Ferric iron from anoxygenic photosynthesis and oxygen in local oases likely mobilized some U during the Archean Era when there was very little O2 in the air. Conversely, these elements behave similarly in the absence of life, where the elements occur as U(IV) and Th(IV), which do not significantly fractionate during igneous processes. Neither do they fractionate during weathering, as they are essentially insoluble in water in surface environments. Th(IV) and U(IV) remain in solid clay-sized material. Overall, geoneutrino data constrain the masses of mantle chemical and isotopic domains recognized by studies of mantle-derived rocks and show the extent of recycling into the mantle over geological time.

  4. Effect of High-Frequency Electric Field on Propagation of Electrostatic Wave in a Non-Uniform Relativistic Plasma Waveguide

    Institute of Scientific and Technical Information of China (English)



    The effect of a high frequency (HF) electric field on the propagation of electrostatic wave in a 2D non-uniform relativistic plasma waveguide is investigated. A variable separation method is applied to the two-fluid plasma model. An analytical study of the reflection of electro-static wave propagation along a magnetized non-uniform relativistic plasma slab subjected to an intense HF electric field is presented and compared with the case of a non relativistic plasma. It is found that, when the frequency of the incident wave is close to the relativistic electron plasma frequency, the plasma is less reflective due to the presence of both an HF field and the effect of rel-ativistic electrons. On the other hand, for a low-frequency incident wave the reflection coefficient is directly proportional to the amplitude of the HF field. Also, it is shown that the relativistic electron plasma leads to a decrease in the value of reflection coefficient in comparison with the case of the non relativistic plasma.

  5. A Mechanism of the Effect of Non-uniform Current on the Spectrum of Short Wind Waves

    Institute of Scientific and Technical Information of China (English)

    ZHENG Guizhen; SHENG Lifang; CONG Peixiu


    A mechanism is suggested in this paper concerning the effect of non-uniform current on the spectrum of short wind waves. According to this mechanism, a non-uniform current brings changes to the breaking criteria of short wind waves through modulating the surface drift, and hence enhances or weakens wave breaking. Some modification is proposed to the source term, which represents the spectral rate of wave energy dissipation due to wave breaking so that the source term can incorporate this mechanism. In order to illustrate whether this mechanism is significant, a real case is studied, in which the wind waves propagate on a tidal current flowing over the sea bottom covered with sand waves. Finally, the effect of the new mechanism on the equilibrium spectrum of small scale gravity waves is discussed. Numerical estimates suggest that, for water depths less than 50 m and wavelengths less than 1 m, this current field may result in distinct spatial variations of the wave breaking criteria, the spectral rate of wave energy dissipation and the equilibrium spectrum of short gravity waves.

  6. Effect of non-uniform basic temperature gradients on Marangoni convection with a boundary slab of finite conductivity

    Directory of Open Access Journals (Sweden)

    Shivakumara I S,


    Full Text Available The linear stability analysis of Marangoni convection in a fluid layer with a boundary slab of finite conductivity is considered. The effects of various non uniform temperature gradients are investigated. The lower boundary is a considered to be a thin slab of finite conductivity instead of a regular rigid surface. At the contact surface between the thin slab and the fluid layer the thermalboundary conditions are used and the upper surface is considered to be free and insulating to temperature perturbation and also surface tension effects are allowed. The resulting eigen value problem is solved exactly. The critical values of the Marangoni numbers for the onset of Marangoni convection are calculated for different temperature profile and the latter is found to be critically dependent on the depth ratio and conductivity ratio. The effects of the thermal conductivity and the thickness of the solid plate on the onset of convective instability with different temperature profile arestudied in detail.

  7. SIX2 Effects on Wilms Tumor Biology

    Directory of Open Access Journals (Sweden)

    Janene Pierce


    Full Text Available Wilms tumor (WT blastema retains gene expression profiles characteristic of the multipotent nephron progenitor pool, or cap mesenchyme (CM, in the developing kidney. As a result, WT blastema and the CM are believed to represent contextual analogues of one another. Sine oculis homeobox 2 (SIX2 is a transcription factor expressed specifically in the CM, provides a critical mechanism for CM self-renewal, and remains persistently active in WT blastema, although its purpose in this childhood malignancy remains unclear. We hypothesized that SIX2, analogous to its function in development, confers a survival pathway to blastema, the putative WT stem cell. To test its functional significance in WT biology, wild-type SIX2 was overexpressed in the human WT cell line, WiT49. After validating this model, SIX2 effects on anchorage-independent growth, proliferation, invasiveness, canonical WNT pathway signaling, and gene expression of specific WNT pathway participants were evaluated. Relative to controls, WiT49 cells overexpressing SIX2 showed significantly enhanced anchorage-independent growth and early-passage proliferation representing surrogates of cell survival. Interestingly, overexpression of SIX2 generally repressed TCF/LEF-dependent canonical WNT signaling, which activates and coordinates both differentiation and stem pathways, but significantly heightened canonical WNT signaling through the survivin promoter, a mechanism that exclusively maintains the stem state. In summary, when overexpressed in a human WT cell line, SIX2 enhances cell survival and appears to shift the balance in WNT/β-catenin signaling away from a differentiation path and toward a stem cell survival path.

  8. Effects of non-uniform core flow on peak cladding temperature: MOXY/SCORE sensitivity calculations

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S.C.


    The MOXY/SCORE computer program is used to evaluate the potential effect on peak cladding temperature of selective cooling that may result from a nonuniform mass flux at the core boundaries during the blowdown phase of the LOFT L2-4 test. The results of this study indicate that the effect of the flow nonuniformity at the core boundaries will be neutralized by a strong radial flow redistribution in the neighborhood of core boundaries. The implication is that the flow nonuniformity at the core boundaries has no significant effect on the thermal-hydraulic behavior and cladding temperature at the hot plane.

  9. The effective potential of composite fields in weakly coupled QED in a uniform external magnetic field

    CERN Document Server

    Lee, D S; Ng, Y J; Shovkovy, I A


    The effective potential for the composite fields responsible for chiral symmetry breaking in weakly coupled QED in a magnetic field is derived. The global minimum of the effective potential is found to acquire a non-vanishing expectation value of the composite fields that leads to generating the dynamical fermion mass by an external magnetic field. The results are compared with those for the Nambu-Jona-Lasinio model.

  10. Effects of Individualized Assignments on Biology Achievement. (United States)

    Kremer, Philip L.


    Compared detailed (favoring field dependence and induction) and nondetailed (favoring field dependence and deduction) assignments on biology achievement of grade 10 male students (N=95) over a seven-month period. Detailed assignments, employing pictorial and verbal block diagrams and high structure, significantly enhanced learning among some…

  11. The Biological Effects of Nonionizing Radiation. (United States)


    surrounding C-12-81 normal tissues. According to N.W. Bleehan, this was the method used by Hippocrates , with the aid of a hot iron. Hippocrates , by the way, is...temporal pattern of desired increases of tempera - ture in the body; (2) the biological consequences of doing this must be established and evaluated

  12. Technology Rich Biology Labs: Effects of Misconceptions. (United States)

    Kuech, Robert; Zogg, Gregory; Zeeman, Stephan; Johnson, Mark

    This paper describes a study conducted on the lab sections of the general biology course for non-science majors at the University of New England, and reports findings of student misconceptions about photosynthesis and the mass/carbon uptake during plant growth. The current study placed high technology analytic tools in the hands of introductory…

  13. Viscous effects in a static physical model of the uniform glottis. (United States)

    Fulcher, Lewis P; Scherer, Ronald C; Powell, Travis


    The classic work on laryngeal flow resistance by van den Berg et al. [J. Acoust. Soc. Am. 29, 626-631 (1957)] is revisited. These authors used a formula to summarize their measurements, and thus they separated the effects of entrance loss and pressure recovery from those of viscosity within the glottis. Analysis of intraglottal pressure distributions obtained from the physical model M5 [R. Scherer et al., J. Acoust. Soc. Am. 109, 1616-1630 (2001)] reveals substantial regions within the glottis where the pressure gradient is almost constant for glottal diameters from 0.005 to 0.16 cm, as expected when viscous effects dominate the flow resistance of a narrow channel. For this set of glottal diameters, the part of the pressure gradient that has a linear dependence on the glottal volume velocity is isolated. The inverse cube diameter of the Poiseuille expression for glottal flows is examined with the data set provided by the M5 intraglottal pressure distributions. The Poiseuille effect is found to give a reasonable account of viscous effects in the diameter interval from 0.0075 to 0.02 cm, but an inverse 2.59 power law gives a closer fit across all diameters.

  14. Spectral hole burning effects initiated by uniform signal intensities in a gain-flattened EDFA

    Institute of Scientific and Technical Information of China (English)

    A. R. Sarmani; S-J Sheih; F. R. Mahamd Adikan; M. A. Mahdi


    @@ Spectral hole burning (SHB) effects in a gain-flattened erbium-doped fiber amplifier (EDFA) are demonstrated to be significant in the presence of large signal power around the 1530-1532-nm wavelength range. These are the first effects reported in a setup employing equivalent power level distribution of 40 channels ranging from 1530 to 1561 nm. To explain this, the introduction of a new local population variable into the laser equation is required to support the original inversion ratio that is determined by the pump lasers. In the analysis section, spectroscopic parameters and high signal powers are considered to be other contributing parameters to the change in the gain characteristics. An improvement to this theoretical basis is suggested by implementing mathematical modeling to validate similarities between the gain shape of simulation to that obtained in the experiment.%Spectral hole burning (SHB) effects in a gain-fiattened erbium-doped fiber amplifier (EDFA) are demonstrated to be significant in the presence of large signal power around the 1530-1532-nm wavelength range.These are the first effects reported in a setup employing equivalent power level distribution of 40 channels ranging from 1530 to 1561 nm. To explain this, the introduction of a new local population variable into the laser equation is required to support the original inversion ratio that is determined by the pump lasers.In the analysis section, spectroscopic parameters and high signal powers are considered to be other contributing parameters to the change in the gain characteristics. An improvement to this theoretical basis is suggested by implementing mathematical modeling to validate similarities between the gain shape of simulation to that obtained in the experiment.

  15. The Effect of a Pre-Lens Aperture on the Temperature Range and Image Uniformity of Microbolometer Infrared Cameras

    Energy Technology Data Exchange (ETDEWEB)

    Dinwiddie, Ralph Barton [ORNL; Parris, Larkin S. [Wichita State University; Lindal, John M. [Oak Ridge National Laboratory (ORNL); Kunc, Vlastimil [ORNL


    This paper explores the temperature range extension of long-wavelength infrared (LWIR) cameras by placing an aperture in front of the lens. An aperture smaller than the lens will reduce the radiance to the sensor, allowing the camera to image targets much hotter than typically allowable. These higher temperatures were accurately determined after developing a correction factor which was applied to the built-in temperature calibration. The relationship between aperture diameter and temperature range is linear. The effect of pre-lens apertures on the image uniformity is a form of anti-vignetting, meaning the corners appear brighter (hotter) than the rest of the image. An example of using this technique to measure temperatures of high melting point polymers during 3D printing provide valuable information of the time required for the weld-line temperature to fall below the glass transition temperature.

  16. Chiral and Parity Symmetry Breaking for Planar Fermions: Effects of a Heat Bath and Uniform External Magnetic Field

    CERN Document Server

    Ayala, Alejandro; Gutierrez, Enif; Raya, Alfredo; Sanchez, Angel


    We study chiral symmetry breaking for relativistic fermions, described by a parity violating Lagrangian in 2+1-dimensions, in the presence of a heat bath and a uniform external magnetic field. Working within their four-component formalism allows for the inclusion of both parity-even and -odd mass terms. Therefore, we can define two types of fermion anti-fermion condensates. For a given value of the magnetic field, there exist two different critical temperatures which would render one of these condensates identically zero, while the other would survive. Our analysis is completely general: it requires no particular simplifying hierarchy among the energy scales involved, namely, bare masses, field strength and temperature. However, we do reproduce some earlier results, obtained or anticipated in literature, corresponding to special kinematical regimes for the parity conserving case. Relating the chiral condensate to the one-loop effective Lagrangian, we also obtain the magnetization and the pair production rate ...

  17. SEMICONDUCTOR TECHNOLOGY Effects of the reciprocating parameters of the carrier on material removal rate and non-uniformity in CMP (United States)

    Cailing, Wang; Renke, Kang; Zhuji, Jin; Dongming, Guo


    Based on the Preston equation, the mathematical model of the material removal rate (MRR), aiming at a line-orbit chemical mechanical polisher, is established. The MRR and the material removal non-uniformity (MRNU) are numerically calculated by MATLAB, and the effects of the reciprocating parameters on the MRR and the MRNU are discussed. It is shown that the smaller the inclination angle and the larger the amplitude, the higher the MRR and the lower the MRNU. The reciprocating speed of the carrier plays a minor role to improve the MRR and decrease the MRNU. The results provide a guide for the design of a polisher and the determination of a process in line-orbit chemical mechanical polishing.

  18. Effects of non-uniform root zone salinity on water use, Na+ recirculation, and Na+ and H+ flux in cotton. (United States)

    Kong, Xiangqiang; Luo, Zhen; Dong, Hezhong; Eneji, A Egrinya; Li, Weijiang


    A new split-root system was established through grafting to study cotton response to non-uniform salinity. Each root half was treated with either uniform (100/100 mM) or non-uniform NaCl concentrations (0/200 and 50/150 mM). In contrast to uniform control, non-uniform salinity treatment improved plant growth and water use, with more water absorbed from the non- and low salinity side. Non-uniform treatments decreased Na(+) concentrations in leaves. The [Na(+)] in the '0' side roots of the 0/200 treatment was significantly higher than that in either side of the 0/0 control, but greatly decreased when the '0' side phloem was girdled, suggesting that the increased [Na(+)] in the '0' side roots was possibly due to transportation of foliar Na(+) to roots through phloem. Plants under non-uniform salinity extruded more Na(+) from the root than those under uniform salinity. Root Na(+) efflux in the low salinity side was greatly enhanced by the higher salinity side. NaCl-induced Na(+) efflux and H(+) influx were inhibited by amiloride and sodium orthovanadate, suggesting that root Na(+) extrusion was probably due to active Na(+)/H(+) antiport across the plasma membrane. Improved plant growth under non-uniform salinity was thus attributed to increased water use, reduced leaf Na(+) concentration, transport of excessive foliar Na(+) to the low salinity side, and enhanced Na(+) efflux from the low salinity root.

  19. Effects of Spatial Characteristics on Smart Antenna System with Uniform Linear Antenna Array

    Institute of Scientific and Technical Information of China (English)

    CAO Wei-feng; WANG Wen-bo


    The effect of the spatial characteristics of antenna array on smart antenna systems can not be neglected. In the paper, the relation between spatial correlation and inter-antenna distance, impinging angle, angle spread is first investigated. With the same beamforming algorithm, we simulate the performance of smart antenna system with different Angle Spread (AS) values on the conditions of ideal and real Angle of Arrival (AOA) estimation. The results show that with the ideal AOA estimation, the AOA is enough accurate to guarantee that the system only has little performance degradation even in the case of 20 degreee AS value while the real AOA estimation influenced by channel environment degrades the performance very obviously, up to about 7 dB.

  20. Critical dimension uniformity and contact edge roughness in extreme ultraviolet lithography: effect of photoacid generator, sensitizer and quencher (United States)

    Kuppuswamy, Vijaya-Kumar Murugesan; Constantoudis, Vassilios; Gogolides, Evangelos; Pret, Alessandro Vaglio; Gronheid, Roel


    One of the main challenges for developing extreme ultraviolet resists is to satisfy critical dimension uniformity (CDU) and sidewall roughness of contacts to the allowable limit. To this end, further understanding of the effects of resist ingredients on CDU and contact edge roughness (CER) is required. We investigate the effects of a photoacid generator (PAG), sensitizer and quencher concentrations on the CDU and CER. We find that the dependencies of CDU on sensitizer and quencher are dominated by photon shot noise (PSN) effects whereas a more complicated interplay between PSN and PAG distribution statistics should be considered in the dependence of CDU on PAG concentration. The estimated CER parameters [root mean square (RMS) value and correlation length ξ] exhibit a merging trend when plotted against the final critical dimension (CD). In addition, RMS value increases with exposure dose and PAG loading contrary to shot noise expectations. Power spectrum analysis reveals the dominant contribution of low-frequency undulations to CER, which is attributed to the enhanced interaction along specific directions between the aerial image and/or acid kinetics of nearby contacts. This inter-contact effect is further intensified with CD for fixed pitch and may explain the observed CER behavior.

  1. Dressed for Success? The Effect of School Uniforms on Student Achievement and Behavior. NBER Working Paper No. 17337 (United States)

    Gentile, Elisabetta; Imberman, Scott A.


    Uniform use in public schools is rising, but we know little about how they affect students. Using a unique dataset from a large urban school district in the southwest United States, we assess how uniforms affect behavior, achievement and other outcomes. Each school in the district determines adoption independently, providing variation over schools…

  2. Non-Thermal Effects Mobile Phones at Biological Objects


    Ladislav Balogh


    The article deals with non-thermal effects of mobile phones on biological objects. Even though these effects are observed for longer period, there are not so far unequivocal results on obtained biological and biophysical results in this field. Biologicaleffects of electromagnetic field (EMF) depend on its character, its duration as well as on features of organism. As the receptors offield are not known (e.g. inputs of EMF into organism), its effects are judged only by non-specific reaction of...

  3. Topical Day on Biological Effects of Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Baatout, S.; Jacquet, P.


    The topical day has been focussed on the potential effects of ionizing radiation on human health. A general overview on molecular and biophysical aspects of radiation, its effects on cells and organisms, and the contribution of radiobiology to radiation protection and risk assessment is given. The genetic effects of radiation and its effects on the developing organism, the effects of radiation on the cell cycle and the mechanisms of radiation induced apoptosis were also discussed.

  4. Iron diminishes the in vitro biological effect of vanadium. (United States)

    Mechanistic pathways underlying inflammatory injury following exposures to vanadium-containing compounds are not defined. We tested the postulate that the in vitro biological effect of vanadium results from its impact on iron homeostasis. Human bronchial epithelial (HBE) cells ex...

  5. Critical appraisal: dental amalgam update--part II: biological effects. (United States)

    Wahl, Michael J; Swift, Edward J


    Dental amalgam restorations have been controversial for over 150 years. In Part I of this Critical Appraisal, the clinical efficacy of dental amalgam was updated. Here in Part II, the biological effects of dental amalgam are addressed.

  6. Effects of Drip System Uniformity and Irrigation Amount on Water and Salt Distributions in Soil Under Arid Conditions

    Institute of Scientific and Technical Information of China (English)

    GUAN Hong-jie; LI Jiu-sheng; LI Yan-feng


    The dynamics of water and salt in soil were monitored in the 2010 and 2011 growing seasons of cotton to evaluate the salinity risk of soil under drip irrigation in arid environments for different management practices of drip system uniformity and irrigation amount. In the experiments, three Christiansen uniformity coefficients (CU) of approximately 65, 80, and 95%(referred to as low, medium, and high uniformity, respectively) and three irrigation amounts of 50, 75, and 100%of full irrigation were used. The distribution of the soil water content and bulk electrical conductivity (ECb) was monitored continuously with approximately equally spaced frequency domain reflectometry (FDR) sensors located along a dripline. Gravimetric samples of soil were collected regularly to determine the distribution of soil salinity. A great fluctuation in CU of water content and ECb at 60 cm depth was observed for the low uniformity treatment during the irrigation season, while a relatively stable variation pattern was observed for the high uniformity treatment. The ECb CU was substantially lower than the water content CU and its value was greatly related to the water content CU and the initial ECb CU. The spatial variation of seasonal mean soil water content and seasonal mean soil bulk electrical conductivity showed a high dependence on the variation pattern of emitter discharge rate along a dripline for the low and medium uniformity treatments. A greater irrigation amount produced a significantly lower soil salinity at the end of the irrigation season, while the influence of the system uniformity on the soil salinity was insignificant at a probability level of 0.1. In arid regions, the determination of the target drip irrigation system uniformity should consider the potential salinity risk of soil caused by nonuniform water application as the influence of the system uniformity on the distribution of the soil salinity was progressively strengthened during the growing season of crop.

  7. Crossover from the coffee-ring effect to the uniform deposit caused by irreversible cluster-cluster aggregation (United States)

    Crivoi, A.; Zhong, X.; Duan, Fei


    The coffee-ring effect for particle deposition near the three-phase line after drying a pinned sessile colloidal droplet has been suppressed or attenuated in many recent studies. However, there have been few attempts to simulate the mitigation of the effect in the presence of strong particle-particle attraction forces. We develop a three-dimensional stochastic model to investigate the drying process of a pinned colloidal sessile droplet by considering the sticking between particles, which was observed in the experiments. The Monte Carlo simulation results show that by solely promoting the particle-particle attraction in the model, the final deposit shape is transformed from the coffee ring to the uniform film deposition. This phenomenon is modeled using the colloidal aggregation technique and explained by the "Tetris principle," meaning that unevenly shaped or branched particle clusters rapidly build up a sparse structure spanning throughout the entire domain in the drying process. The influence of the controlled parameters is analyzed as well. The simulation is reflected by the drying patterns of the nanofluid droplets through the surfactant control in the experiments.

  8. Hormesis [Biological Effects of Low Level Exposures (Belle)] and Dermatology


    Thong, Haw-Yueh; Maibach, Howard I.


    Hormesis, or biological effects of low level exposures (BELLE), is characterized by nonmonotonic dose response which is biphasic, displaying opposite effects at low and high dose. Its occurrence has been documented across a broad range of biological models and diverse type of exposure. Since hormesis appears to be a relatively common phenomenon in many areas, the objective of this review is to explore its occurrence related to dermatology and its public health and risk assessment implication....

  9. Biological effects of exposure to magnetic resonance imaging: an overview


    Formica Domenico; Silvestri Sergio


    Abstract The literature on biological effects of magnetic and electromagnetic fields commonly utilized in magnetic resonance imaging systems is surveyed here. After an introduction on the basic principles of magnetic resonance imaging and the electric and magnetic properties of biological tissues, the basic phenomena to understand the bio-effects are described in classical terms. Values of field strengths and frequencies commonly utilized in these diagnostic systems are reported in order to a...

  10. Biological Effects of the Great Oxidation Event (United States)

    Schopf, J.


    Fossil evidence of photoautotrophy, documented in Precambrian sediments by stromatolites, stromatolitic microfossils, and carbon isotopic data consistent with autotrophic CO2-fixation, extends to ~3,500 Ma. Such data, however, are insufficient to establish the time of origin of O2-producing (cyanobacterial) photosynthesis from its anoxygenic, photosynthetic bacterial, evolutionary precursor. The oldest (Paleoarchean) stromatolites may have been formed by anoxygenic photoautotrophs, rather than the cyanobacteria that dominate Proterozoic and modern stromatolites. Unlike the cyanobacteria of Proterozoic microbial assemblages, the filamentous and coccoidal microfossils of Archean deposits may represent remnants of non-O2-producing prokaryotes. And although the chemistry of Archean organic matter shows it to be biogenic, its carbon isotopic composition is insufficient to differentiate between oxygenic and anoxygenic sources. Though it is well established that Earth's ecosystem has been based on autotrophy since its early stages and that O2-producing photosynthesis evolved earlier, perhaps much earlier, than the increase of atmospheric oxygen in the ~2,450 and ~2,320 Ma Great Oxidation Event (GOE), the time of origin of oxygenic photoautotrophy has yet to be established. Recent findings suggest that Earth's ecosystem responded more or less immediately to the GOE. The increase of atmospheric oxygen markedly affected ocean water chemistry, most notably by increasing the availability of biologically usable oxygen (which enabled the development of obligate aerobes, such as eukaryotes), and of nitrate, sulfate and hydrogen sulfide (the increase of H2S being a result of microbial reduction of sulfate), the three reactants that power the anaerobic basis of sulfur-cycling microbial sulfuretums. Fossil evidence of the earliest eukaryotes (widely accepted to date from ~1800 Ma and, arguably, ~2200 Ma) fit this scenario, but the most telling example of life's response to the GOE

  11. Effects of Non-Uniform Wall Heating on Thermal and Momentum Fields in a 3-Dimensional Urban Environment (United States)

    Nazarian, N.; Kleissl, J. P.


    As urbanization progresses, microclimate modifications are also aggravated and the increasing environmental concerns call for more sophisticated methods of urban microclimate analysis. Comprehensive numerical simulations for a clear summer day in southern California are performed in a compact low-rise urban environment. The effect of realistic unsteady, non-uniform thermal forcing, that is caused by solar insolation and inter-building shadowing on thermal and flow conditions are analyzed based on Algebraic Wall-Modeled Large Eddy Simulation (LES) model. The urban thermal field is influenced by urban density, material properties and local weather conditions, as well as urban canyon flow. Urban canyon conditions are translated into vertical and horizontal bulk Richardson numbers indicating atmospheric instability and solar tilt with respect to the momentum forcing of the canyon vortex, respectively. The effect of roof heating is found to be critical on the vortex formation between buildings when the vertical bulk Richardson number is low. Variations of Convective Heat Transfer Coefficients (CHTCs) along building walls are studied and the street canyon ventilation performance is characterized by the mean of air exchange rate (ACH). It is found that volumetric air exchange from street canyons, as well as the distribution of heat transfer along the wall depends strongly on the three-dimensional orientation of the heated wall in relation to wind direction. For example, air removal increases by surface heating and is larger when the leeward wall is heated. In summary, we demonstrate the importance of considering complex realistic conditions on 3-dimensional thermal and momentum fields in Urban Environments.

  12. Biological effects of fruit and vegetables

    DEFF Research Database (Denmark)

    Dragsted, L. O.; Krath, B.; Ravn-Haren, Gitte;


    , providing 600hairspg fruit and vegetables/d or in the controls a carbohydrate-rich drink to balance energy intake. Surrogate markers of oxidative damage to DNA, protein and lipids, enzymic defence and lipid metabolism were determined in blood and urine. It was found that a high intake of fruit......A strong and persistent effect of plant-derived foods on the prevention of lifestyle diseases has emerged from observational studies. Several groups of constituents in plants have been identified as potentially health promoting in animal studies, including cholesterol-lowering factors, antioxidants......, enzyme inducers, apoptosis inducers etc. In human intervention studies the dose levels achieved tend to be lower than the levels found to be effective in animals and sampling from target organs is often not possible. A controlled dietary human intervention study was performed with forty-three volunteers...

  13. Biological and therapeutical effects of Radon

    Energy Technology Data Exchange (ETDEWEB)

    Deetjen, P. [Institute of Physiologie and Balneologie, University of Innsbruck (Austria)


    In spas with a somewhat elevated Radon{sup 222} (Rn) activity (between 300 and 3000 Bq/l), the empirical medicine ended - in all parts of the world - with the same list of indications. It mainly includes the more painful rheumatic diseases such as deformation or degeneration of the joints and non bacterial inflammation of muscles, tendons or joints; Morbus Bechterew and other diseases of the vertebral column like spondylosis, spondylarthrosis or osteochondrosis. While informer times these effects were seldom documented in an objective manner, in recent years several prospective randomized double-blind studies proved the pain reducing efficacy of Radon therapy in patients with cervical pain syndromes, with chronic polyarthritis or with Morbus Bechterew. Studies in experimental animal models have accumulated remarkable data in organs, tissue and cultured cells that provide a rationale to explain the observed effects of Radon therapy in patients. (author)

  14. Palytoxin and Analogs: Biological and Ecological Effects

    Directory of Open Access Journals (Sweden)

    Vítor Ramos


    Full Text Available Palytoxin (PTX is a potent marine toxin that was originally found in soft corals from tropical areas of the Pacific Ocean. Soon after, its occurrence was observed in numerous other marine organisms from the same ecological region. More recently, several analogs of PTX were discovered, remarkably all from species of the dinoflagellate genus Ostreopsis. Since these dinoflagellates are also found in other tropical and even in temperate regions, the formerly unsuspected broad distribution of these toxins was revealed. Toxicological studies with these compounds shows repeatedly low LD50 values in different mammals, revealing an acute toxic effect on several organs, as demonstrated by different routes of exposure. Bioassays tested for some marine invertebrates and evidences from environmental populations exposed to the toxins also give indications of the high impact that these compounds may have on natural food webs. The recognition of its wide distribution coupled with the poisoning effects that these toxins can have on animals and especially on humans have concerned the scientific community. In this paper, we review the current knowledge on the effects of PTX and its analogs on different organisms, exposing the impact that these toxins may have in coastal ecosystems.

  15. The Effect of the Double-Deck Filament Setup on Enhancing the Uniformity of Temperature Field on Long-Flute Cutting Tools (United States)

    Shen, Bin; Chen, Sulin; Cheng, Lei; Sun, Fanghong


    In the present study, a double-deck filament setup is proposed for the hot filament chemical vapor deposition (HFCVD) method and an optimization method is presented to determine its optimal geometry that is able to produce a highly uniform temperature field on the whole flute surface of long-flute cutting tools. The optimization method is based on the finite volume method (FVM) simulation and the Taguchi method. The simulation results show that this double-deck filament setup always produce a highly uniform temperature distribution along the filament direction. Comparatively, for the temperature uniformity along the drill axis, the heights of the two filament decks present virtually significant influence, while the separations between the two filaments in either deck exhibit a relative weak effect. An optimized setup is obtained that can produce a highly uniform temperature field with an average temperature of 834°C, a standard deviation (σ) of 2.59°C and a temperature range (R) of 11.75°C. Finally, the precision of the proposed simulation method is verified by an additional temperature measurement. The measured temperature results show that a highly uniform temperature fields with σ/R = 9.6/35.2°C can be generated by the optimized setup and the deviation of the simulated results from the measured actual temperatures are within 0.5-3.5%, which justifies the correctness of the simulation method proposed in present study.

  16. Quasi-uniform Space

    Directory of Open Access Journals (Sweden)

    Coghetto Roland


    Full Text Available In this article, using mostly Pervin [9], Kunzi [6], [8], [7], Williams [11] and Bourbaki [3] works, we formalize in Mizar [2] the notions of quasiuniform space, semi-uniform space and locally uniform space.

  17. Linking exposure to environmental pollutants with biological effects

    DEFF Research Database (Denmark)

    Sørensen, Mette; Autrup, Herman; Møller, Peter


    Exposure to ambient air pollution has been associated with cancer. Ambient air contains a complex mixture of toxics, including particulate matter (PM) and benzene. Carcinogenic effects of PM may relate both to the content of PAH and to oxidative DNA damage generated by transition metals, benzene......, metabolism and inflammation. By means of personal monitoring and biomarkers of internal dose, biologically effective dose and susceptibility, it should be possible to characterize individual exposure and identify air pollution sources with relevant biological effects. In a series of studies, individual......, biological effects of air pollutants appear mainly related to oxidative stress via personal exposure and not to urban background levels. Future developments include personal time-resolved monitors for exposure to ultrafine PM and PM(2.5,) use of GPS, as well as genomics and proteomics based biomarkers....

  18. Biological effects of stellar collapse neutrinos

    CERN Document Server

    Collar, J I


    Massive stars in their final stages of collapse radiate most of their binding energy in the form of MeV neutrinos. The recoil atoms that they produce in elastic scattering off nuclei in organic tissue create a radiation damage which is highly effective in the production of irreparable DNA harm, leading to cellular mutation, neoplasia and oncogenesis. Using a conventional model of the galaxy and of the collapse mechanism, the periodicity of nearby stellar collapses and the radiation dose are calculated. The possible contribution of this process to the paleontological record of mass extinctions is examined.

  19. Nanosilver – Harmful effects of biological activity

    Directory of Open Access Journals (Sweden)

    Anna Maria Świdwińska-Gajewska


    Full Text Available Nanosilver, also identified as colloidal silver, has been known and used for ages to combat diseases or prolong food freshness. It usually occurs in the form of a suspension consisting of particles of size < 100 nm. Due to its specific properties, silver nanoparticles are used in many technologies to produce medical devices, textiles, conductive materials or photovoltaic cells. The growing popularity of nanosilver applications increases the number of people occupationally exposed to this substance. Potential exposure routes for silver nanoparticles are through dermal, oral and inhalation pathways. Silver nanoparticles may be absorbed through the lungs, intestine, and through the skin into circulation and thus may reach such organs as the liver, kidney, spleen, brain, heart and testes. Nanosilver may cause mild eyes and skin irritations. It can also act as a mild skin allergen. Inhalation of silver nanoparticles mainly affects the lungs and liver. It has been demonstrated that silver nanoparticles may be genotoxic to mammalian cells. There are some alarming reports on the adverse effects of silver nanoparticles on reproduction of experimental animals. Exposure to silver nanoparticles may exert a neurotoxic effect and affect cognitive functions, causing the impairment of short-term and working memory. Maximum admissible concentration (MAC for the inhalable fraction of silver of 0.05 mg/m3 is currently binding in Poland. In light of toxicological studies of silver nanoparticles it seems reasonable to update the hygiene standards for silver with nanoparticles as a separate fraction. Med Pr 2014;65(6:831–845

  20. School Uniforms Redux. (United States)

    Dowling-Sendor, Benjamin


    Reviews a recent decision in "Littlefield" by the 5th Circuit upholding a school uniform policy. Advises board member who wish to adopt a school uniform policy to solicit input from parents and students, research the experiences of other school districts with uniform policies, and articulate the interests they wish to promote through uniform…

  1. Effects of forced wall vibration on the onset of flow instability and critical heat flux in uniformly-heated microchannels (United States)

    Stromberger, Jorg Hermann

    Numerous experimental and theoretical investigations on two-phase flow instability and burnout in heated microchannels have been reported in the literature. However none of these investigations deals with the possible effects of wall vibrations on such flow boiling processes within microchannels. Fluid-structure interaction in ultra high power density systems cooled by high velocity single phase forced convection in microchannels may result in vibration amplitudes that are a significant fraction of the diameter of the channel. Such vibrations may significantly impact vapor bubble dynamics at the wall and, hence, the limiting heat fluxes corresponding to the onset of flow instability and/or burnout. The primary purpose of this research was to experimentally quantify the effect of forced wall vibration on the onset of flow instability (OFI) and the critical heat flux (CHF) in uniformly-heated annular microchannels. The secondary interest of this investigation was to compare the experimental data collected in the single-phase regime to commonly used single-phase forced convection correlations. Experimental data acquired in the flow boiling regime were to be utilized to confirm the validity of common flow boiling correlations for microchannel flow. The influence of forced wall vibration on subcooled single-phase forced convection and flow boiling was examined. The Georgia Tech Microchannel Test Facility (GTMTF) was modified to allow such experiments to be conducted at controlled values of transverse wall vibration amplitudes and accelerations for a range of frequencies. The channel demand curves were obtained for various inner and outer surface heat fluxes. Experiments were conducted for broad ranges of transverse wall vibration amplitudes over a range of frequencies. The experiments conducted in this investigation provide designers of high power density systems cooled by forced convection in microchannels with the appropriate data and correlations to confidently

  2. Electromagnetic field induced biological effects in humans. (United States)

    Kaszuba-Zwoińska, Jolanta; Gremba, Jerzy; Gałdzińska-Calik, Barbara; Wójcik-Piotrowicz, Karolina; Thor, Piotr J


    Exposure to artificial radio frequency electromagnetic fields (EMFs) has increased significantly in recent decades. Therefore, there is a growing scientific and social interest in its influence on health, even upon exposure significantly below the applicable standards. The intensity of electromagnetic radiation in human environment is increasing and currently reaches astronomical levels that had never before experienced on our planet. The most influential process of EMF impact on living organisms, is its direct tissue penetration. The current established standards of exposure to EMFs in Poland and in the rest of the world are based on the thermal effect. It is well known that weak EMF could cause all sorts of dramatic non-thermal effects in body cells, tissues and organs. The observed symptoms are hardly to assign to other environmental factors occurring simultaneously in the human environment. Although, there are still ongoing discussions on non-thermal effects of EMF influence, on May 31, 2011--International Agency for Research on Cancer (IARC)--Agenda of World Health Organization (WHO) has classified radio electromagnetic fields, to a category 2B as potentially carcinogenic. Electromagnetic fields can be dangerous not only because of the risk of cancer, but also other health problems, including electromagnetic hypersensitivity (EHS). Electromagnetic hypersensitivity (EHS) is a phenomenon characterized by the appearance of symptoms after exposure of people to electromagnetic fields, generated by EHS is characterized as a syndrome with a broad spectrum of non-specific multiple organ symptoms including both acute and chronic inflammatory processes located mainly in the skin and nervous systems, as well as in respiratory, cardiovascular systems, and musculoskeletal system. WHO does not consider the EHS as a disease-- defined on the basis of medical diagnosis and symptoms associated with any known syndrome. The symptoms may be associated with a single source of EMF

  3. Biological effect of radiation on human

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yun Sil; Cho, Chul Koo; Lee, Su Jae [and others


    1. Adaptive response when 0.01 Gy was preirradiated before high challenging dose is induced in normal cell types such normal lymphocytes, primary keratinocytes, and L929 fibroblast cells but not in neoplastic cells such as L5178Y lymphoma cells, EL-4 lymphoma cells and 308 papilloma cells. 2. Heat shock protein (HSP) 25 and inducible HSP70 is responsible for the induction of adaptive response and radioresistance - cell cycle regulation, antiapoptotic molecule and PKC activation were involved. 3. Apoptosis was induced at most 5. hrs after irradiation in primary keratinocytes, in v-rasHa transformed keratinocytes, the maximum interval was 16 hrs, and in 308 papilloma cells, the maximum was 48 hrs. 4. PKC response by radiation is correlated with induction of apoptosis. 5. Rapid induction PKCdelta in primary keratinocytes and no response of PKC epsilon may involved in radiation induced apoptosis. 6. The rate of resorption was increased when radiation was given at 2.5 days after gestation. Early death including foetal death were highly expressed when radiation was given at 7.5 days after gestation. There are no difference in incidence of late death including embryonic death. 7. 2 Gy is the most effective dose in radiation induced teratogenesis in mouse model. 8. Growth retardation and small head was present when radiation was given at 5.5, 7.5, 11.5 and 15.5 days after gestation and small head showed high incidence at 11.5 days after gestation. 9. External malformation, internal malformation and skeletal malformation was induced when radiation was given at 7.5 days after gestation. 10. OGG1-mutated cells induced radiosensitive by G2/M cell cycle arrest. 11. Radiation induced G2/M phase cell cycle and correlated with radiosensitivity. 12. PKCalpha induced differentiation. 13. Radiation exposed cells showed carcinogenic effect. 14. Organ specific radiosensitivity was shown and protein expression was involved.

  4. Biologic

    CERN Document Server

    Kauffman, L H


    In this paper we explore the boundary between biology and the study of formal systems (logic). In the end, we arrive at a summary formalism, a chapter in "boundary mathematics" where there are not only containers but also extainers ><, entities open to interaction and distinguishing the space that they are not. The boundary algebra of containers and extainers is to biologic what boolean algebra is to classical logic. We show how this formalism encompasses significant parts of the logic of DNA replication, the Dirac formalism for quantum mechanics, formalisms for protein folding and the basic structure of the Temperley Lieb algebra at the foundations of topological invariants of knots and links.

  5. Effects of radiation heat transfer space non-uniformity of combustion chamber components on in-cylinder soot emission formation in diesel engine

    Institute of Scientific and Technical Information of China (English)


    Combustion chamber components (cylinder head-cylinder liner-piston assembly-fuel film) were treated as a coupled body. Based on the three-dimensional numerical simulation of heat transfer of the coupled body, the multi-dimensional simulation computation coupling flow and solid on working process and combustion chamber components of internal combustion engine was performed using Discrete Transfer Radiation Model (DTRM) radiation heat transfer model, zoning solution method and boundary coupling method. The simulation was applied to the influence investigation of the space non-uniformity in radiation heat transfer among combustion chamber components on the generation of in-cylinder soot emissions. The results show that the space non-uniformity in heat transfer among the combustion chamber components has great influence on the generation of in-cylinder NOx emissions. The difference value of total soot in cylinder when exhaust valves are opened is 1.3% (no radiation), 0.8% (radiation). So the effect of radiation heat transfer space non-uniformity of combustion chamber components on total soot production can be ignored. While in local area radiation heat transfer space non-uniformity has certain effect on soot production inside whole combustion chamber space, and has less effect on soot production in the area near the wall of combustion chamber components.

  6. Third eye, the biological effects; 3. oeil, les effets biologiques

    Energy Technology Data Exchange (ETDEWEB)



    The discovery of a third kind of photo-receptor cell in the human eye has permitted to better understand the biological effects of lighting, not only on the vision, but also on some nervous processes, like emotion, mood, stress, biological clock, etc.. This additional dimension has led the engineers of Philips Lighting company to launch a new indoor lighting concept named 'Carpe Diem'. This concept adapts both the illuminance and the color of a lighting system according to the type of work and to the expected stimulating effect. (J.S.)

  7. Biological effect of penetration controlled irradiation with ion beams

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Atsushi; Shimizu, Takashi; Kikuchi, Masahiro; Kobayashi, Yasuhiko; Watanabe, Hiroshi [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment; Yamashita, Takao


    To investigate the effect of local irradiation with ion beams on biological systems, technique for penetration controlled irradiation has been established. The range in a target was controlled by changing the distance from beam window in the atmosphere, and could be controlled linearly up to about 31 {mu}m in biological material. In addition, the effects of the penetration controlled irradiations with 1.5 MeV/u C and He ions were examined using tobacco pollen. The increased frequency of leaky pollen produced by ion beams suggests that the efficient pollen envelope damages would be induced at the range-end of ion beams. (author)

  8. Concentration polarization effects on the macromolecular transport in the presence of non-uniform magnetic field: A numerical study using a lumen-wall model

    Energy Technology Data Exchange (ETDEWEB)

    Mohammadpourfard, M., E-mail: [Department of Mechanical Engineering, Azarbaijan Shahid Madani University, Tabriz 53751-71379 (Iran, Islamic Republic of); Aminfar, H., E-mail: [Faculty of Mechanical Engineering, University of Tabriz, Tabriz (Iran, Islamic Republic of); Khajeh, K., E-mail: [Faculty of Mechanical Engineering, University of Tabriz, Tabriz (Iran, Islamic Republic of)


    In this paper, the concentration polarization phenomena in a two dimensional tube under steady state conditions containing ferrofluid (blood and 4 vol% Fe{sub 3}O{sub 4}) is reported in the presence of non-uniform magnetic field. Lumen-wall model has been used for solving the mass transport equation. Hemodynamics parameters such as flow rate, viscosity, wall shear stress (WSS) and the macromolecules surface concentration which accumulate on the blood vessel wall, influenced the formation and progression of atherosclerosis disease. Effective parameters on the low density lipoprotein (LDL) surface concentration (LSC) such as: the wall filtration velocity, inlet Reynolds number and WSS under applied non-uniform magnetic field have been examined. Numerical solution of governing equations of the flow field have been obtained by using the single-phase model and the control volume technique. Magnetic field is generated by an electric current going through a thin and straight wire oriented perpendicular to the tube. Results show WSS in the vicinity of magnetic field source increased and LSC decreased along the wall. - Highlights: • In this paper the concentration polarization phenomena of blood flow is reported in the presence of non-uniform magnetic field. • In presence of non-uniform magnetic field LSC will decrease along the wall due to the increasing the velocity gradients near the magnetic source. • When non-uniform magnetic field intensity increases, LSC along the wall becomes lower. • Non-uniform magnetic field can affects the flow more in low Reynolds numbers.

  9. Plasma effects in electromagnetic field interaction with biological tissue (United States)

    Sharma, R. P.; Batra, Karuna; Excell, Peter S.


    Theoretical analysis is presented of the nonlinear behavior of charge carriers in biological tissue under the influence of varying low-intensity electromagnetic (EM) field. The interaction occurs because of the nonlinear force arising due to the gradient of the EM field intensity acting on free electrons in the conduction band of proteins in metabolically active biological cell membrane receptors leading to a redistribution of charge carriers. Field dependence of the resulting dielectric constant is investigated by a suitable modification to include an additional electronic contribution term to the three-term Debye model. The exogenous EM field propagating in this nonlinear cellular medium satisfies the nonlinear Schrödinger equation and can be affected significantly. Resulting field effect can be substantially augmented and effective rectification/demodulation can occur. Possible implications of this modification on biological processes in white and grey matter are discussed.

  10. Challenges in Analyzing the Biological Effects of Resveratrol

    DEFF Research Database (Denmark)

    Erdogan, Cihan Süleyman; Vang, Ole


    The suggested health effects (e.g., disease prevention) of dietary bioactive compounds such as resveratrol are challenging to prove in comparison to man-made drugs developed for therapeutic purposes. Dietary bioactive compounds have multiple cellular targets and therefore have a variety of biolog...

  11. The effect of fan speed control system on the inlet air temperature uniformity in a solar dryer

    Directory of Open Access Journals (Sweden)

    S. F Mousavi


    Full Text Available Introduction: Drying process of agricultural products, fruits and vegetables are highly energy demanding and hence are the most expensive postharvest operation. Nowadays, the application of control systems in different area of science and engineering plays a key role and is considered as the important and inseparable parts of any industrial process. The review of literature indicates that enormous efforts have been donefor the intelligent control of solar driers and in this regard some simulation models are used through computer programming. However, because of the effect of air velocity on the inlet air temperature in dryers, efforts have been made to control the fan speed based ont he temperature of the absorber plate in this study, and the behavior of this system was compared with an ordinary dryer without such a control system. Materials and methods: In this study, acabinet type solar dryer with forced convection and 5kg capacity of fresh herbs was used. The dryer was equipped with a fan in the outlet chamber (the chimney for creating air flow through the dryer. For the purpose of research methods and automatic control of fan speed and for adjusting the temperature of the drying inlet air, a control system consisting of a series of temperature and humidity sensors and a microcontroller was designed. To evaluatethe effect of the system with fan speed control on the uniformity of air temperature in the drying chamber and hence the trend of drying process in the solar dryer, the dryer has been used with two different modes: with and without the control of fan speed, each in twodays (to minimize the errors of almost the same ambient temperature. The ambient air temperature during the four days of experiments was obtained from the regional Meteorological Office. Some fresh mint plants (Mentha longifolia directly harvested from the farm in the morning of the experiment days were used as the drying materials. Each experimental run continued for 9

  12. High-order above-threshold ionization the uniform approximation and the effect of the binding potential

    CERN Document Server

    De Faria, C F M; Becker, W


    A versatile semiclassical approximation for intense laser-atom processes is presented. This uniform approximation is no more complicated than the frequently-used multi-dimensional saddle-point approximation and far superior, since it applies for all energies, both close to as well as away from classical cutoffs. In the latter case, it reduces to the standard saddle-point approximation. The uniform approximation agrees accurately with numerical evaluations for potentials, for which these are feasible, and constitutes a practicable method of calculation in general. The method is applied to the calculation of high-order above-threshold ionization spectra with various binding potentials: Coulomb, Yukawa, and shell potentials which may model C$_{60}$ molecules or clusters. The shell potentials generate high-order ATI spectra that are more structured and may feature an apparently higher cutoff.

  13. Adaptation hypothesis of biological effectiveness of ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Kudritsky, Yu.K.; Georgievsky, A.B.; Karpov, V.I.


    The adoptation hypothesis of biological effectiveness of ionizing radiations is based on the recognition of the invariability of general biological laws for radiobiology and on the comprehension of life evolution regularities and axiomatic principles of environment and biota unity. The ionizing radiation factor is essential for life which could not exist beyond the radiation field. The possibility of future development of the adaptation hypothesis serves as a basis for it`s transformation into the theoretical foundation of radiobiology. This report discusses the aspects of the adaptation theory.

  14. Student Dress Codes and Uniforms. Research Brief (United States)

    Johnston, Howard


    According to an Education Commission of the States "Policy Report", research on the effects of dress code and school uniform policies is inconclusive and mixed. Some researchers find positive effects; others claim no effects or only perceived effects. While no state has legislatively mandated the wearing of school uniforms, 28 states and…

  15. Effect of biologic agents on radiographic progression of rheumatoid arthritis

    Directory of Open Access Journals (Sweden)

    Gabriel J Tobón


    Full Text Available Gabriel J Tobón1, Alain Saraux1,2, Valérie Devauchelle-Pensec1,21Immunology Laboratory, Morvan Hospital, Université de Bretagne Occidentale, Brest, France; 2Rheumatology Unit, Hôpital de la Cavale Blanche, CHU Brest, FranceAbstract: The treatment of rheumatoid arthritis (RA has benefited over the last few years from the introduction of biologic agents whose development was based on new insights into the immunological factors involved in the pathogenesis of RA and the development of joint damage. These biological agents have been proven effective in RA patients with inadequate responses to synthetic disease-modifying antirheumatic drugs (DMARDs. Preventing joint damage is now the primary goal of RA treatment, and guidelines exist for the follow-up of joint abnormalities. Most biologic agents produced high clinical and radiological response rates in patients with established or recent-onset RA. Thus, for the first time, obtaining a remission is a reasonable treatment goal in RA patients. Factors that are crucial to joint damage control are: early initiation of DMARDs, use of intensive treatments including biological agents, and close monitoring of clinical disease activity and radiographic progression. However, some patients remain unresponsive to all available treatments and continue to experience joint damage progression. A major objective now is to identify patients at high risk for severe joint damage, in order to tailor the treatment regimen to their specific needs.Keywords: rheumatoid arthritis, radiographic progression, biologics

  16. Predictive modeling of nanomaterial exposure effects in biological systems

    Directory of Open Access Journals (Sweden)

    Liu X


    Full Text Available Xiong Liu,1 Kaizhi Tang,1 Stacey Harper,2 Bryan Harper,2 Jeffery A Steevens,3 Roger Xu1 1Intelligent Automation, Inc., Rockville, MD, USA; 2Department of Environmental and Molecular Toxicology, School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR, USA; 3ERDC Environmental Laboratory, Vicksburg, MS, USA Background: Predictive modeling of the biological effects of nanomaterials is critical for industry and policymakers to assess the potential hazards resulting from the application of engineered nanomaterials. Methods: We generated an experimental dataset on the toxic effects experienced by embryonic zebrafish due to exposure to nanomaterials. Several nanomaterials were studied, such as metal nanoparticles, dendrimer, metal oxide, and polymeric materials. The embryonic zebrafish metric (EZ Metric was used as a screening-level measurement representative of adverse effects. Using the dataset, we developed a data mining approach to model the toxic endpoints and the overall biological impact of nanomaterials. Data mining techniques, such as numerical prediction, can assist analysts in developing risk assessment models for nanomaterials. Results: We found several important attributes that contribute to the 24 hours post-fertilization (hpf mortality, such as dosage concentration, shell composition, and surface charge. These findings concur with previous studies on nanomaterial toxicity using embryonic zebrafish. We conducted case studies on modeling the overall effect/impact of nanomaterials and the specific toxic endpoints such as mortality, delayed development, and morphological malformations. The results show that we can achieve high prediction accuracy for certain biological effects, such as 24 hpf mortality, 120 hpf mortality, and 120 hpf heart malformation. The results also show that the weighting scheme for individual biological effects has a significant influence on modeling the overall impact of

  17. Uniform magnesium oxide adsorbents (United States)

    Dash, J. G.; Ecke, R.; Stoltenberg, J.; Vilches, O. E.; Whittemore, O. J., Jr.


    Kr adsorption on MgO is used to characterize the surface uniformity of MgO smoke and thermally decomposed Mg(OH)2. It is found that initially heterogeneous samples develop progressively sharper stepwise isotherms with increasingly-high-temperature heat treatment, apparently due to the removal of imperfections and high-energy facets, leaving surfaces of highly uniform (100) planes.

  18. Games Uniforms Unveiled

    Institute of Scientific and Technical Information of China (English)



    The uniforms for Beijing Olympics’ workers, technical staff and volunteers have been unveiled to mark the 200-day countdown to the Games. The uniforms feature the key element of the clouds of promise and will be in three colors:red for Beijing Olympic Games Committee staff, blue

  19. School Uniforms. Research Brief (United States)

    Walker, Karen


    Does clothing make the person or does the person make the clothing? How does what attire a student wears to school affect their academic achievement? In 1996, President Clinton cited examples of school violence and discipline issues that might have been avoided had the students been wearing uniforms ("School uniforms: Prevention or suppression?").…

  20. Biological effects of exposure to magnetic resonance imaging: an overview

    Directory of Open Access Journals (Sweden)

    Formica Domenico


    Full Text Available Abstract The literature on biological effects of magnetic and electromagnetic fields commonly utilized in magnetic resonance imaging systems is surveyed here. After an introduction on the basic principles of magnetic resonance imaging and the electric and magnetic properties of biological tissues, the basic phenomena to understand the bio-effects are described in classical terms. Values of field strengths and frequencies commonly utilized in these diagnostic systems are reported in order to allow the integration of the specific literature on the bio-effects produced by magnetic resonance systems with the vast literature concerning the bio-effects produced by electromagnetic fields. This work gives an overview of the findings about the safety concerns of exposure to static magnetic fields, radio-frequency fields, and time varying magnetic field gradients, focusing primarily on the physics of the interactions between these electromagnetic fields and biological matter. The scientific literature is summarized, integrated, and critically analyzed with the help of authoritative reviews by recognized experts, international safety guidelines are also cited.

  1. Effect of light source instability on uniformity of 3D reconstructions from a cone beam optical CT scanner. (United States)

    Begg, J; Taylor, M L; Holloway, L; Kron, T; Franich, R D


    Temporally varying light intensity during acquisition of projection images in an optical CT scanner can potentially be misinterpreted as physical properties of the sample. This work investigated the impact of LED light source intensity instability on measured attenuation coefficients. Different scenarios were investigated by conducting one or both of the reference and data scans in a 'cold' scanner, where the light source intensity had not yet stabilised. Uniform samples were scanned to assess the impact on measured uniformity. The orange (590 nm) light source decreased in intensity by 29 % over the first 2 h, while the red (633 nm) decreased by 9 %. The rates of change of intensity at 2 h were 0.1 and 0.03 % respectively over a 5 min period-corresponding to the scan duration. The normalisation function of the reconstruction software does not fully account for the intensity differences and discrepancies remain. Attenuation coefficient inaccuracies of up to 8 % were observed for data reconstructed from projection images acquired with a cold scanner. Increased noise was observed for most cases where one or both of the scans was acquired without sufficient warm-up. The decrease in accuracy and increase in noise were most apparent for data reconstructed from reference and data scans acquired with a cold scanner on different days.

  2. The effect of stirring in the hydrothermal process to convert the mixed municipal solid waste into uniform solid fuel (United States)

    Prawisudha, P.; Mu'min, G. F.; Yoshikawa, K.; Pasek, A. D.


    An innovative waste treatment technology has been developed in Indonesia to treat the mixed municipal solid waste into a solid fuel by employing the hydrothermal process. A mixture of organic and plastic waste was treated in a 2.5 L reactor using saturated steam in the temperature range of 120 to 180 °C. Two modes of operation were employed to achieve two different goals, i.e. without stirring (NS mode) and with stirring (WS mode). It was observed that both modes resulted in increasing density of product up to twofold of the raw MSW. In NS mode, the processed mixed MSW was converted into two different products; however, in WS mode the bulky plastic was converted into small granules, producing a uniform product. The results suggest that by hydrothermal treatment, the organic fibers in the organic parts are trapped into the plastic, and the stirring breaks the bulky plastics, producing uniform granules suitable as solid fuel. Therefore, the stirring during the hydrothermal process can be a solution to treat the MSW as it is, without any separation, to produce a clean and renewable energy source.

  3. Effect of linear surface-charge non-uniformities on the electrokinetic ionic-current rectification in conical nanopores. (United States)

    Qian, Shizhi; Joo, Sang W; Ai, Ye; Cheney, Marcos A; Hou, Wensheng


    The electrokinetic ionic-current rectification in a conical nanopore with linearly varying surface-charge distributions is studied theoretically by using a continuum model composed of a coupled system of the Nernst-Planck equations for the ionic-concentration field and the Poisson equation for the electric potential in the electrolyte solution. The numerical analysis includes the electrochemistry inside reservoirs connected to the nanopore, neglected in previous studies, and more precise accounts of the ionic current are provided. The surface-charge distribution, especially near the tip of the nanopore, significantly affects the ionic enrichment and depletion, which, in turn, influence the resulting ionic current and the rectification. It is shown that non-uniform surface-charge distribution can reverse the direction, or sense, of the rectification. Further insights into the ionic-current rectification are provided by discussing the intriguing details of the electric potential and ionic-concentration fields, leading to the rectification. Rationale for future studies on ionic-current rectification, associated with other non-uniform surface-charge distributions and electroosmotic convection for example, is discussed.

  4. Advances in the biological effects of terahertz wave radiation. (United States)

    Zhao, Li; Hao, Yan-Hui; Peng, Rui-Yun


    The terahertz (THz) band lies between microwave and infrared rays in wavelength and consists of non-ionizing radiation. Both domestic and foreign research institutions, including the army, have attached considerable importance to the research and development of THz technology because this radiation exhibits both photon-like and electron-like properties, which grant it considerable application value and potential. With the rapid development of THz technology and related applications, studies of the biological effects of THz radiation have become a major focus in the field of life sciences. Research in this field has only just begun, both at home and abroad. In this paper, research progress with respect to THz radiation, including its biological effects, mechanisms and methods of protection, will be reviewed.

  5. Advances in the biological effects of terahertz wave radiation

    Institute of Scientific and Technical Information of China (English)

    Li Zhao; Yan-Hui Hao; Rui-Yun Peng


    The terahertz (THz) band lies between microwave and infrared rays in wavelength and consists of non-ionizing radiation. Both domestic and foreign research institutions, including the army, have attached considerable importance to the research and development of THz technology because this radiation exhibits both photon-like and electron-like properties, which grant it considerable application value and potential. With the rapid development of THz technology and related applications, studies of the biological effects of THz radiation have become a major focus in the field of life sciences. Research in this field has only just begun, both at home and abroad. In this paper, research progress with respect to THz radiation, including its biological effects, mechanisms and methods of protection, will be reviewed.

  6. Controlling the biological effects of spermine using a synthetic receptor. (United States)

    Vial, Laurent; Ludlow, R Frederick; Leclaire, Julien; Pérez-Fernandez, Ruth; Otto, Sijbren


    Polyamines play an important role in biology, yet their exact function in many processes is poorly understood. Artificial host molecules capable of sequestering polyamines could be useful tools for studying their cellular function. However, designing synthetic receptors with affinities sufficient to compete with biological polyamine receptors remains a huge challenge. Binding affinities of synthetic hosts are typically separated by a gap of several orders of magnitude from those of biomolecules. We now report that a dynamic combinatorial selection approach can deliver a synthetic receptor that bridges this gap. The selected receptor binds spermine with a dissociation constant of 22 nM, sufficient to remove it from its natural host DNA and reverse some of the biological effects of spermine on the nucleic acid. In low concentrations, spermine induces the formation of left-handed DNA, but upon addition of our receptor, the DNA reverts back to its right-handed form. NMR studies and computer simulations suggest that the spermine complex has the form of a pseudo-rotaxane. The spermine receptor is a promising lead for the development of therapeutics or molecular probes for elucidating spermine's role in cell biology.

  7. Effect of pH on biological phosphorus uptake. (United States)

    Serralta, J; Ferrer, J; Borrás, L; Seco, A


    An anaerobic aerobic laboratory scale sequencing batch reactor (SBR) was operated to study the effect of pH on enhanced biological phosphorus removal. Seven steady states were achieved under different operating conditions. In all of them, a slight variation in the pH value was observed during anaerobic phase. However, pH rose significantly during aerobic phase. The increase observed was due to phosphorus uptake and carbon dioxide stripping. When pH was higher than 8.2-8.25 the phosphorus uptake rate clearly decreased. The capability of Activated Sludge Model No. 2d (ASM2d) and Biological Nutrient Removal Model No. 1 (BNRM1) to simulate experimental results was evaluated. Both models successfully characterized the enhanced biological phosphorus removal performance of the SBR. Furthermore, BNRM1 also reproduced the pH variations observed and the decrease in the phosphorus uptake rate. This model includes a switch function in the kinetic expressions to represent the pH inhibition in biological processes. The pH inhibition constants related to polyphosphate storage process were obtained by adjusting model predictions to measured phosphorus concentrations. On the other hand, pH inhibition should be included in ASM2d to accurately simulate experimental phosphorus evolution observed in an A/O SBR.

  8. Effect of Ceramic Scaffold Architectural Parameters on Biological Response

    Directory of Open Access Journals (Sweden)

    Maria Isabella eGariboldi


    Full Text Available Numerous studies have focused on the optimization of ceramic architectures to fulfill a variety of scaffold functional requirements and improve biological response. Conventional fabrication techniques, however, do not allow for the production of geometrically controlled, reproducible structures and often fail to allow the independent variation of individual geometric parameters. Current developments in additive manufacturing technologies suggest that 3D printing will allow a more controlled and systematic exploration of scaffold architectures. This more direct translation of design into structure requires a pipeline for design-driven optimization. A theoretical framework for systematic design and evaluation of architectural parameters on biological response is presented. Four levels of architecture are considered, namely (1 surface topography, (2 pore size and geometry, (3 porous networks and (4 macroscopic pore arrangement, including the potential for spatially varied architectures. Studies exploring the effect of various parameters within these levels are reviewed. This framework will hopefully allow uncovering of new relationships between architecture and biological response in a more systematic way, as well as inform future refinement of fabrication techniques to fulfill architectural necessities with a consideration of biological implications.

  9. Effect of Ceramic Scaffold Architectural Parameters on Biological Response. (United States)

    Gariboldi, Maria Isabella; Best, Serena M


    Numerous studies have focused on the optimization of ceramic architectures to fulfill a variety of scaffold functional requirements and improve biological response. Conventional fabrication techniques, however, do not allow for the production of geometrically controlled, reproducible structures and often fail to allow the independent variation of individual geometric parameters. Current developments in additive manufacturing technologies suggest that 3D printing will allow a more controlled and systematic exploration of scaffold architectures. This more direct translation of design into structure requires a pipeline for design-driven optimization. A theoretical framework for systematic design and evaluation of architectural parameters on biological response is presented. Four levels of architecture are considered, namely (1) surface topography, (2) pore size and geometry, (3) porous networks, and (4) macroscopic pore arrangement, including the potential for spatially varied architectures. Studies exploring the effect of various parameters within these levels are reviewed. This framework will hopefully allow uncovering of new relationships between architecture and biological response in a more systematic way as well as inform future refinement of fabrication techniques to fulfill architectural necessities with a consideration of biological implications.


    Directory of Open Access Journals (Sweden)

    Tossaporn Incharoen


    Full Text Available Our two experiments were intended to investigate the effects of dietary Whole Rice Hull (WRH as insoluble fiber on the flock uniformity of pullets and the performance, egg quality and intestinal mucosa structure of laying hens. In experiment 1, a total of 1,500 chicks (4 weeks old with the same uniform weight were randomly separated into three treatments of 500 birds each and fed diets containing 0 (control, 3 and 6% WRH. With increasing dietary WRH levels, body weight and feed intake were higher (p<0.05; the 3 and 6% WRH groups were higher than the control group. The Feed Conversion Ratio (FCR was lowest (p<0.05 in the 3% WRH-fed birds. In addition, the percentage of flock uniformity tended to increase in both dietary WRH groups. In the experiment 2, a total of 48 of the highest-producing hens (32 weeks old were divided into three groups of 16 birds each and fed diets containing 0, 3 and 6% WRH. Hen-day egg production was 2.56% higher in the 6% WRH group and 1.48% higher in the 3% WRH group than in the control, without any distinctly adverse effects on egg quality. Morphologically, no significant differences were observed in the light microscopic parameters, with the exception that the muscularis externa width showed a higher value in the duodenum of the 6% WRH group and in the ileum of both dietary WRH groups. Epithelial cellular phenomena of the jejunum and ileum were similar among treatments, except cell clusters with numerous protuberated epithelia were found in the 6% WRH group. In conclusion, the current data indicate that WRH can be used as a source of insoluble fiber in diets up to 6% to enhance growth and uniformity of pullet chicks and to improve egg production of laying hens without any harmful impact on egg quality or on the intestinal mucosa structure.

  11. Intuitive biological thought: Developmental changes and effects of biology education in late adolescence. (United States)

    Coley, John D; Arenson, Melanie; Xu, Yian; Tanner, Kimberly D


    A large body of cognitive research has shown that people intuitively and effortlessly reason about the biological world in complex and systematic ways. We addressed two questions about the nature of intuitive biological reasoning: How does intuitive biological thinking change during adolescence and early adulthood? How does increasing biology education influence intuitive biological thinking? To do so, we developed a battery of measures to systematically test three components of intuitive biological thought: anthropocentric thinking, teleological thinking and essentialist thinking, and tested 8th graders and university students (both biology majors, and non-biology majors). Results reveal clear evidence of persistent intuitive reasoning among all populations studied, consistent but surprisingly small differences between 8th graders and college students on measures of intuitive biological thought, and consistent but again surprisingly small influence of increasing biology education on intuitive biological reasoning. Results speak to the persistence of intuitive reasoning, the importance of taking intuitive knowledge into account in science classrooms, and the necessity of interdisciplinary research to advance biology education. Further studies are necessary to investigate how cultural context and continued acquisition of expertise impact intuitive biology thinking.

  12. Observation of the integer quantum Hall effect in high quality, uniform wafer-scale epitaxial graphene films (United States)

    Pan, Wei; Howell, Stephen W.; Ross, Anthony Joseph; Ohta, Taisuke; Friedmann, Thomas A.


    We report the observation of the integer quantum Hall states at Landau level fillings of ν =2, 6, and 10 in a Hall bar device made of a single-layer epitaxial graphene film on the silicon-face of silicon-carbide prepared via argon-assisted graphitization. The two-dimensional electron gas exhibits a low-temperature (at 4 K) carrier mobility of ˜14 000 cm2/V s at the electron density of 6.1×1011 cm-2. Furthermore, the sheet resistance obtained from four-probe measurements across the whole area (12×6 mm2) of another specimen grown under similar condition displays roughly uniform values (˜1600 Ω/square), suggesting that the macroscopic steps and accompanying multilayer graphene domains play a minor role in the low-temperature electronic transport.

  13. Effect of Antenna Type on the Capacity of Body-to-Body Capacity When Using Uniform Power Allocation

    KAUST Repository

    Ghanem, Khalida


    Body-area networks are led to target multimedia applications where high-data rate is involved. In this paper, the characterization of the measured body-to-body channels and the ergodic capacity with uniform power allocation is discussed when using multiple-input multiple-output (MIMO) PIFA and IFA antenna systems. This capacity is compared to the measured belt-head and belt-chest on-body channels using PIFA antennas in the same environment. It is shown that body channels reach less ergodic capacity than the equivalent Rayleigh channel because of the presence of a LOS component. The capacity is the same for the body-to-body case regardless of the antenna and the on-body channels reach better capacity values compared to these former. © 2012 IEEE.

  14. Biological effects from electromagnetic field exposure and public exposure standards. (United States)

    Hardell, Lennart; Sage, Cindy


    During recent years there has been increasing public concern on potential health risks from power-frequency fields (extremely low frequency electromagnetic fields; ELF) and from radiofrequency/microwave radiation emissions (RF) from wireless communications. Non-thermal (low-intensity) biological effects have not been considered for regulation of microwave exposure, although numerous scientific reports indicate such effects. The BioInitiative Report is based on an international research and public policy initiative to give an overview of what is known of biological effects that occur at low-intensity electromagnetic fields (EMFs) exposure. Health endpoints reported to be associated with ELF and/or RF include childhood leukaemia, brain tumours, genotoxic effects, neurological effects and neurodegenerative diseases, immune system deregulation, allergic and inflammatory responses, breast cancer, miscarriage and some cardiovascular effects. The BioInitiative Report concluded that a reasonable suspicion of risk exists based on clear evidence of bioeffects at environmentally relevant levels, which, with prolonged exposures may reasonably be presumed to result in health impacts. Regarding ELF a new lower public safety limit for habitable space adjacent to all new or upgraded power lines and for all other new constructions should be applied. A new lower limit should also be used for existing habitable space for children and/or women who are pregnant. A precautionary limit should be adopted for outdoor, cumulative RF exposure and for cumulative indoor RF fields with considerably lower limits than existing guidelines, see the BioInitiative Report. The current guidelines for the US and European microwave exposure from mobile phones, for the brain are 1.6 W/Kg and 2 W/Kg, respectively. Since use of mobile phones is associated with an increased risk for brain tumour after 10 years, a new biologically based guideline is warranted. Other health impacts associated with exposure to

  15. Effect of annealing, thickness ratio and bend angle on springback of AA6061-T6 with non-uniform thickness section

    Directory of Open Access Journals (Sweden)

    Adnan M.F.


    Full Text Available Non-uniform thickness section section is considered one of the most effective approaches to reduce automotive part weight. Reduction in term of mass and size result in less fuel consumption and greenhouse gases. Thickness is the most significant parameter to formability, therefore forming a section with non-uniform thickness becomes a great challenge. Improper process and incorrect decision may lead to severe defect and one of the main concerns is the springback. This study will focus on springback behaviour of non-uniform thickness AA6061 strip with complex profile using Taguchi Method. Profile projector (PC 3000 is used to measure the spring back and two-line technique is applied to measure angles (after loading between two lines. Three parameters (i.e. annealing temperature, thickness ratio and bend angle are studied, and results determine that the most significant parameter is bend angle, followed by thickness ratio, and then by the annealing temperature of the specimen during bending process.

  16. Biological effects of low level exposures to chemicals and radiation

    Energy Technology Data Exchange (ETDEWEB)

    Calabrese, E.J. (ed.)


    In May 1990 a group of scientists representing several federal agencies, the International Society of Regulatory Toxicology and Pharmacology, the private sector, and academia met to develop a strategy to encourage the study of the biological effects of low level exposures (BELLE) to chemical agents and radioactivity. A workshop was held in 1991 with seven invited speakers focusing on the toxicological implications of biological adaptations. The selection of topics and speakers was designed to consider critically the concept of hormesis, not only in a broad, conceptual manner, but also at the molecular and biochemical levels. These presentations offered a complementary perspective on the diverse range of molecular mechanisms that can become activated at low levels of toxicant exposure. In addition to chemical toxicology research, an overview of current research on Effects of low-dose radiation on the immune response' was presented as well as Cellular adaptation as an important response during chemical carcinogenesis'. The final presentation was devoted to biostatistical considerations when designing studies that address issues associated with the biological responses to low doses of chemicals and radiation, as well as issues in interpretation of the findings from such studies.

  17. Biological effects of pulsating magnetic fields: role of solitons

    CERN Document Server

    Brizhik, Larissa


    In this paper, we analyze biological effects produced by magnetic fields in order to elucidate the physical mechanisms, which can produce them. We show that there is a chierarchy of such mechanisms and that the mutual interplay between them can result in the synergetic outcome. In particular, we analyze the biological effects of magnetic fields on soliton mediated charge transport in the redox processes in living organisms. Such solitons are described by nonlinear systems of equations and represent electrons that are self-trapped in alpha-helical polypeptides due to the moderately strong electron-lattice interaction. They represent a particular type of disssipativeless large polarons in low-dimensional systems. We show that the effective mass of solitons in the is different from the mass of free electrons, and that there is a resonant effect of the magnetic fields on the dynamics of solitons, and, hence, on charge transport that accompanies photosynthesis and respiration. These effects can result in non-therm...

  18. A radio-frequency system for in vivo pilot experiments aimed at the studies on biological effects of electromagnetic fields. (United States)

    Ardoino, Lucia; Lopresto, Vanni; Mancini, Sergio; Marino, Carmela; Pinto, Rosanna; Lovisolo, Giorgio A


    An exposure system consisting of two long transversal electromagnetic (TEM) cells, operating at a frequency of 900 MHz, is presented and discussed. The set-up allows simultaneous exposure of a significant number of animals (up to 12 mice per cell) in a blind way to a uniform plane wave at a frequency of 900 MHz, for investigating possible biological effects of exposure to electromagnetic fields produced by wireless communication systems. A heating/refrigerating system has also been designed for maintaining comfortable environmental conditions within the TEM cells during experiments. An accurate dosimetric study has been performed both numerically and by means of direct measurements on phantoms and living mice. The results have shown that good homogeneity of exposure and adequate power efficiency, in terms of whole-body specific absorption rate (SAR) per 1 W of input power, are achievable for the biological target.

  19. Relative biological effectiveness of the boron neutron-capture beam for the inactivation of biological macromolecules

    Energy Technology Data Exchange (ETDEWEB)

    Saito, Masahiro (Kyoto Univ., Kumatori, Osaka (Japan). Research Reactor Inst.)


    The r.b.e. values of the boron neutron-capture beam (BNCB) for inactivation of yeast alcohol dehydrogenase (YADH) and the coenzyme NADH were determined in aqueous and air-saturated state. The r.b.e. value for YADH was 0.24 at a protein concentration of 0.2 mg/ml and that for NADH at the same concentration was 0.4. These r.b.e. values are less than unity in contrast to the r.b.e. values of BNCB for cell killing and mutagenesis which usually exceed 2. The small r.b.e. values for biological macromolecules is mainly explained from a relatively low yield of the radical species OH and H produced by high LET radiations compared to low LET radiations. Dithiothreitol protected YADH efficiently against inactivation by BNCB. It was suggested that radical repair process is the major cause of the observed radioprotective effect. (author).

  20. School uniforms: tradition, benefit or predicament?


    Van Aardt, Annette Marie; Wilken, Ilani


    This article focuses on the controversies surrounding school uniforms. Roleplayers in this debate in South Africa are parents, learners and educators, and arguments centre on aspects such as identity, economy and the equalising effect of school uniforms, which are considered in the literature to be benefits. Opposing viewpoints highlight the fact that compulsory uniforms infringe on learners’ constitutional rights to self-expression. The aim of this research was to determine the perspectives ...

  1. A quality index for equivalent uniform dose (United States)

    Henríquez, Francisco Cutanda; Castrillón, Silvia Vargas


    Equivalent uniform dose (EUD) is the absorbed dose that, when homogeneously given to a tumor, yields the same mean surviving clonogen number as the given non-homogeneous irradiation. EUD is used as an evaluation tool under the assumption that two plans with the same value of EUD are equivalent, and their biological effect on the tumor (clonogen survival) would be the same as the one of a homogeneous irradiation of absorbed dose EUD. In this work, this assumption has been studied, and a figure of merit of its applicability has been obtained. Distributions of surviving clonogen number for homogeneous and non-homogeneous irradiations are found to be different even if their mean values are the same, the figure of merit being greater when there is a wider difference, and the equivalence assumption being less valid. Therefore, EUD can be closer to a uniform dose for some cases than for other ones (high α values, extreme heterogeneity), and the accuracy of the radiobiological indices obtained for evaluation, could be affected. Results show that the equivalence is very sensitive to the choice of radiobiological parameters, and this conclusion has been derived from mathematical properties of EUD. PMID:21897557

  2. Donor impurity states in a non-uniform quantum strip: Geometrical and electro-magnetic field effects (United States)

    Suaza, Y. A.; Fonnegra-García, D.; Fulla, M. R.; Salazar-Santa, J. D.; Marín, J. H.


    The neutral donor energy structure in non-uniform height quantum strip under the presence of crossed electric and magnetic fields is studied. The quantum strip height has been modeled by including a phenomenological two-parametric function. The first of these parameters is related to the number of structural hills present on the nano-strip, while the second one allows us to control the hills height. We solve the Schrödinger equation by considering specific quantum strips whose height-to-base aspect ratio is very small, which makes possible to calculate numerically the energy structure trough the adiabatic approximation and the exact diagonalization method. In limit cases, our results are in good agreement with those ones previously reported. Periodic oscillations of the ground state energy with magnetic field strength can be tuned by applied electric field which also yields an anti-crossing of the energy levels in a quantum strip with two hills. The energy level structure are strongly sensitive to changes of nano-strip geometrical factors.

  3. Research on the origin of negative effect in uniform doping GaN-based Gunn diode under THz frequency (United States)

    Wang, Shulong; Liu, Hongxia; Zhang, Hailin; Chen, Qing


    The transport properties of GaN-based uniform doping Gunn diode are calculated by an ensemble Monte Carlo method. The drift velocity, electron density, and electric field distribution as a function of time in the device are illustrated under direct current (DC) and alternating current (AC) bias condition. With the help of port current, the relationship between electron transport status and port current can be acquired, which will be useful to understand the origin of negative differential resistance and guide the device design. Different from the traditional opinion, the maximum current do not appear at the same time when electron accumulation domain arrives at device anode. The reason is that when electron accumulation domain comes into heavily doped anode, the velocity will be decelerated a lot for highly ionized impurity scattering, and the electrons in the domain will be used to neutralize positive ion region which provides the electrons during formation of the domain. Some researchers believe that the electrons in the domain come from heavily doped cathode region, but our simulation shows clearly that the electrons come from heavily doped anode side. Finally, the AC simulation shows the possibility of negative differential résistance in GaN diode under THz frequency. What is more, AC simulation result has the same tendency with DC simulation.

  4. A system for investigation of biological effects of diagnostic ultrasound on development of zebrafish embryos. (United States)

    Miller, Douglas L; Zhou, Weibin


    A system for scanning zebrafish embryos with diagnostic ultrasound was developed for research into possible biological effects during development. Two troughs for holding embryos were formed from agarose in a rectangular dish and separated by an ultrasound absorber. A 4.9 MHz linear array ultrasound probe was positioned to uniformly scan all the embryos at the bottom of one trough, with the other used for controls. Zebrafish embryos were scanned continuously from 10-24 h post fertilization (hpf) during the segmentation period and gross morphological parameters were measured at 30 hpf, including viability, length, number of visible axons, and the progression of the lateral line primordium (LLP). Our initial tests were encumbered by the thermal effects of probe self-heating, which resulted in accelerated development of the zebrafish embryos. After subsequent optimization, our test revealed a significant retardation of primary motor axons and the migration of the LLP in embryos scanned with ultrasound, which indicated a potential for nonthermal effects on neuronal development. This diagnostic ultrasound exposure system is suitable for further investigation of possible subtle bioeffects, such as perturbation of neuronal migration.

  5. The Biological Effects of Ivabradine in Cardiovascular Disease

    Directory of Open Access Journals (Sweden)

    Graziano Riccioni


    Full Text Available A large number of studies in healthy and asymptomatic subjects, as well as patients with already established cardiovascular disease (CAD have demonstrated that heart rate (HR is a very important and major independent cardiovascular risk factor for prognosis. Lowering heart rate reduces cardiac work, thereby diminishing myocardial oxygen demand. Several experimental studies in animals, including dogs and pigs, have clarified the beneficial effects of ivabradine associated with HR lowering. Ivabradine is a selective inhibitor of the hyperpolarisation activated cyclic-nucleotide-gated funny current (If involved in pacemaker generation and responsiveness of the sino-atrial node (SAN, which result in HR reduction with no other apparent direct cardiovascular effects. Several studies show that ivabradine substantially and significantly reduces major risks associated with heart failure when added to guideline-based and evidence-based treatment. However the biological effect of ivabradine have yet to be studied. This effects can appear directly on myocardium or on a systemic level improving endothelial function and modulating immune cell migration. Indeed ivabradine is an ‘open-channel’ blocker of human hyperpolarization-activated cyclic nucleotide gated channels of type-4 (hHCN4, and a ‘closed-channel’ blocker of mouse HCN1 channels in a dose-dependent manner. At endothelial level ivabradine decreased monocyte chemotactin protein-1 mRNA expression and exerted a potent anti-oxidative effect through reduction of vascular NADPH oxidase activity. Finally, on an immune level, ivabradine inhibits the chemokine-induced migration of CD4-positive lymphocytes. In this review, we discuss the biological effects of ivabradine and highlight its effects on CAD.

  6. Effect of the Initial Laser Phase on the Interaction Between Relativistic Electron and Ultra-Intense Laser Field in a Strong Uniform Magnetic Field

    Institute of Scientific and Technical Information of China (English)

    HE Xin-Kui; SHUAI Bin; GE Xiao-Chun; LI Ru-Xin; XU Zhi-Zhan


    @@ We investigate the influence of the initial laser phase on the interaction between relativistic electron and ultraintense linear polarized laser field in a strong uniform magnetic field. It is found that the dynamic behaviour of the relativistic electron and the emission spectrum varies dramatically with different initial laser field phases.The effect of changing initial phase is contrary in the two parameter regions divided by the resonance condition.The phase dependence of the electron energy and velocity components are also studied. Some beat structure is found when the initial laser phase is zero and this structure is absent when the initial laser phase is a quarter of a period.

  7. Hydrodynamic collective effects of active proteins in biological membranes

    CERN Document Server

    Koyano, Yuki; Mikhailov, Alexander S


    Lipid bilayers forming biological membranes are known to behave as viscous 2D fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it has been shown [Proc. Nat. Acad. Sci. USA 112, E3639 (2015)] that such active proteins should in- duce non-thermal fluctuating lipid flows leading to diffusion enhancement and chemotaxis-like drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them.

  8. Current research on biological effects of low-level exposures

    Energy Technology Data Exchange (ETDEWEB)

    Sagan, L.A.


    Rather substantial numbers of industrial chemicals, pharmaceuticals, and radiation display U-shaped or seemingly paradoxical dose-response relationships. A limited listing of studies providing examples of data fitting the U-shaped curve has been published. This array suggests that the U-shaped response is broadly generalizable and therefore potentially of considerable significance in the toxicological and public health domains. In fact, in 1992 and 1993, three conferences (Japan, United States, and China) were held exclusively on the topic of the biological effects of low doses of chemicals and radioactivity with articular emphasis on U-shaped curves. Substantial efforts have been made at understanding this observation.

  9. Effects of mechanical dispersion on the morphological evolution of the reaction front during transport in a homogeneous porous medium with initial small non-uniformities (United States)

    Chen, J.-S.; Lai, G.-X.


    The morphological evolution of a chemical dissolution front is an important topic in geological processes and engineering practices. Although previous studies have extensively presented a number of numerical models which couples a system of nonlinear governing equations of porosity change due to mineral dissolution, the conservations of groundwater flow and transport of chemical species to investigate the morphological pattern of a chemical dissolution front within a fluid-saturated porous medium, whereas the mechanical dispersion effect has generally been neglected in the model development. This study addresses the effects of mechanical dispersion on the morphological evolution of a chemical dissolution front for a variety of cases. Mechanical dispersion processes is incorporated with the coupled nonlinear governing equation system so as to rebuild a newly numerical model. The results of numerical simulations demonstrate that mechanical dispersion has pronounced impacts on the morphological pattern of the chemical dissolution front. For single local non-uniformity case, mechanical dispersion reduces the finger length of an unstable single-fingering front or retains the shape of a stable planar front while speeding up the front advancement. In the case of two local non-uniformities, adding mechanical dispersion with different flow conditions can yield one of the following results: (1) the shape of the stable planar front is maintained but its advancement is accelerated; (2) the shape of the unstable single-fingering front is maintained but its length is reduced; (3) the unstable double-fingering front is merged into an unstable single-fingering front; and (4) the shape of the unstable double-fingering front is preserved but its fingering length is reduced.. A comparison between the behavior diagrams of dissolution front morphology (with and without considering mechanical dispersion) shows that the double-fingering front occurs under condition where the upstream

  10. Biological activity of selected plants with adaptogenic effect

    Directory of Open Access Journals (Sweden)

    Eva Ivanišová


    Full Text Available The aim of this study was to determine biological activity of plants with adaptogenic effect: Panax ginseng Mayer., Withania somnifera L., Eleuterococcus senticosus Rupr. et Maxim., Astragallus membranaceus Fisch. and Codonopsis pilosulae Franch. The antioxidant activity was detected by DPPH and phosphomolybdenum method, total polyphenol content with Folin – Ciocalteu reagent, flavonoids content by aluminium chloride method. The detection of antimicrobial activity was carried out by disc diffusion method against three species of Gram-negative bacteria: Escherichia coli CCM 3988, Salmonella enterica subsp. enterica CCM 3807, Yersinia enterocolitica CCM 5671 and two Gram-positive bacteria: Bacillus thuringiensis CCM 19, Stapylococcus aureus subsp. aureus CCM 2461. Results showed that plants with adaptogenic effect are rich for biologically active substances. The highest antioxidant activity by DPPH method was determined in the sample of Eleuterococcus senticosus (3.15 mg TEAC – Trolox equivalent antioxidant capacity per g of sample and by phosphomolybdenum method in the sample of Codonopsis pilosulae (188.79 mg TEAC per g of sample. In the sample of Panax ginseng was measured the highest content of total polyphenols (8.10 mg GAE – galic acid equivalent per g of sample and flavonoids (3.41 μg QE – quercetin equivalent per g of sample. All samples also showed strong antimicrobial activity with the best results in Panax ginseng and Withania somnifera in particular for species Yersinia enterocolitica CCM 5671 and Salmonella enterica subsp. enterica CCM 3807. The analyzed species of plant with high value of biological activity can be used more in the future, not only in food, but also in cosmetics and pharmaceutical industries.

  11. Conjugated linoleic acid isomers: differences in metabolism and biological effects. (United States)

    Churruca, Itziar; Fernández-Quintela, Alfredo; Portillo, Maria Puy


    The term conjugated linoleic acid (CLA) refers to a mixture of linoleic acid positional and geometric isomers, characterized by having conjugated double bonds, not separated by a methylene group as in linoleic acid. CLA isomers appear as a minor component of the lipid fraction, found mainly in meat and dairy products from cows and sheep. The most abundant isomer is cis-9,trans-11, which represents up to 80% of total CLA in food. These isomers are metabolized in the body through different metabolic pathways, but important differences, that can have physiological consequences, are observed between the two main isomers. The trans-10,cis-12 isomer is more efficiently oxidized than the cis-9,trans-11 isomer, due to the position of its double bounds. Interest in CLA arose in its anticarcinogenic action but there is an increasing amount of specific scientific literature concerning the biological effects and properties of CLA. Numerous biological effects of CLA are due to the separate action of the most studied isomers, cis-9,trans-11 and trans-10,cis-12. It is also likely that some effects are induced and/or enhanced by these isomers acting synergistically. Although the cis-9,trans-11 isomer is mainly responsible for the anticarcinogenic effect, the trans-10,cis-12 isomer reduces body fat and it is referred as the most effective isomer affecting blood lipids. As far as insulin function is concerned, both isomers seem to be responsible for insulin resistance in humans. Finally, with regard to the immune system it is not clear whether individual isomers of CLA could act similarly or differently.

  12. Uniformly Convex Metric Spaces


    Kell Martin


    In this paper the theory of uniformly convex metric spaces is developed. These spaces exhibit a generalized convexity of the metric from a fixed point. Using a (nearly) uniform convexity property a simple proof of reflexivity is presented and a weak topology of such spaces is analyzed. This topology called co-convex topology agrees with the usualy weak topology in Banach spaces. An example of a $CAT(0)$-spaces with weak topology which is not Hausdorff is given. This answers questions raised b...

  13. Experimental validation of non-uniformity effect of the radial electric field on the edge transport barrier formation in JT-60U H-mode plasmas (United States)

    Kamiya, Kensaku; Itoh, Kimitaka; Itoh, Sanae-I.; JT-60 Team


    Non-uniformity effects of the edge radial electric field (Er) on the edge transport barriers (ETBs) formation have been identified with high-spatiotemporal resolution spectroscopic measurement. We found the decisive importance of Er-curvature (2nd derivative of Er) on ETB formation during ELM-free H-mode phase, but there is only a low correlation with the Er-shear (1st derivative of Er) value at the peak of normalized ion temperature gradient in the pedestal region. Observation of a uniform toroidal MHD oscillation (i.e. Geodesic Acoustic Mode having toroidal mode number n = 0) during the ETBs formation can also support the hypothesis of turbulence suppression in association with Zonal-flow (and/or Er-curvature). Furthermore, in the ELMing phase, the effect of curvature is also quantified in terms of the relationship between pedestal width and thickness of the layer of inhomogeneous Er. This is the fundamental basis to understand the structure of transport barriers in fusion plasmas. Authors acknowledge the partial support by Grant-in-Aid for Scientific Research (15K06657, 15H02155, 16H02442) and collaboration programmes between QST and universities and of the RIAM of Kyushu University, and by Asada Science Foundation.

  14. Arsenic in the aquatic environment - speciation and biological effects

    Energy Technology Data Exchange (ETDEWEB)

    Landner, L. [Swedish Environmental Research Group (MFG)


    The present report is a contribution to EC Commission`s undertaking to review existing EC provisions on the substances for which Sweden has been granted transitional provisions. The provisions imply that Sweden may maintain more stringent regulations on four substances until the end of 1998. The present report deals with speciation and biological effects of arsenic in three types of aquatic environments - marine water, estuarine or brackish water and freshwater. The similarity between arsenate and phosphate and the interference in phosphorylation reactions is discussed. It is clear that in Scandinavian inland waters the concentration of phosphorous is on average lower than in most inland waters in continental Europe. However, in most inland waters phosphorus is the limiting factor for phytoplankton development and eutrophication, which means that there is a clear risk for detrimental effects in the great majority of inland waters, also eutrophic waters 167 refs, 27 figs, 12 tabs. Exemption Substances Project (Directive 89/677/EEC)

  15. Modeling of biological doses and mechanical effects on bone transduction

    CERN Document Server

    Rieger, Romain; Jennane, Rachid; 10.1016/j.jtbi.2011.01.003


    Shear stress, hormones like parathyroid and mineral elements like calcium mediate the amplitude of stimulus signal which affects the rate of bone remodeling. The current study investigates the theoretical effects of different metabolic doses in stimulus signal level on bone. The model was built considering the osteocyte as the sensing center mediated by coupled mechanical shear stress and some biological factors. The proposed enhanced model was developed based on previously published works dealing with different aspects of bone transduction. It describes the effects of physiological doses variations of Calcium, Parathyroid Hormone, Nitric Oxide and Prostaglandin E2 on the stimulus level sensed by osteocytes in response to applied shear stress generated by interstitial fluid flow. We retained the metabolic factors (Parathyroid Hormone, Nitric Oxide, and Prostaglandin E2) as parameters of bone cell mechanosensitivity because stimulation/inhibition of induced pathways stimulates osteogenic response in vivo. We t...

  16. Significance of including field non-uniformities such as the heel effect and beam scatter in the determination of the skin dose distribution during interventional fluoroscopic procedures (United States)

    Rana, Vijay; Gill, Kamaljit; Rudin, Stephen; Bednarek, Daniel R.


    The current version of the real-time skin-dose-tracking system (DTS) we have developed assumes the exposure is contained within the collimated beam and is uniform except for inverse-square variation. This study investigates the significance of factors that contribute to beam non-uniformity such as the heel effect and backscatter from the patient to areas of the skin inside and outside the collimated beam. Dose-calibrated Gafchromic film (XR-RV3, ISP) was placed in the beam in the plane of the patient table at a position 15 cm tube-side of isocenter on a Toshiba Infinix C-Arm system. Separate exposures were made with the film in contact with a block of 20-cm solid water providing backscatter and with the film suspended in air without backscatter, both with and without the table in the beam. The film was scanned to obtain dose profiles and comparison of the profiles for the various conditions allowed a determination of field non-uniformity and backscatter contribution. With the solid-water phantom and with the collimator opened completely for the 20-cm mode, the dose profile decreased by about 40% on the anode side of the field. Backscatter falloff at the beam edge was about 10% from the center and extra-beam backscatter decreased slowly with distance from the field, being about 3% of the beam maximum at 6 cm from the edge. Determination of the magnitude of these factors will allow them to be included in the skin-dose-distribution calculation and should provide a more accurate determination of peak-skin dose for the DTS.

  17. Late biological effects from internal and external exposure

    Energy Technology Data Exchange (ETDEWEB)

    Adams, W.H.


    Information on late biological effects of radiation was obtained from the long-term medical followup of a small population of Marshallese accidentally exposed to radioactive fallout from a thermonuclear test in 1954. Endocrine data are compatible with a sequence of nonstochastic radiation effects. The ingestion of radioisotopes of iodine produced clinical thyroid hypofunction in children, biochemical evidence of thyroid dysfunction in some adults, thyroid adenomatous module formation, and, as a possible indirect effect of thyroid damage, at least two cases of pituitary adenoma. In contrast, the only evidence of a stochastic effect has been a real increase in thyroid cancers among the more highly exposed people of Rongelap, none of whom have evidence of residual disease. While three nonthyroidal cancers which are known to be inducible in humans by external irradiation have been documented in the exposed population, three similar cancers have occurred in an unexposed comparison population of Marshallese. Nonstochastic effects of radiation exposure may be common but subtle. In the Marshallese experience the morbidity of delayed nonstochastic effects far exceeds that of the stochastic. 20 refs., 5 figs., 1 tab.

  18. Effect of Organic Loading on Rotating Biological Contactor Efficiency

    Directory of Open Access Journals (Sweden)

    Kossay K. Al-Ahmady


    Full Text Available Organic loading (weight per unit time per volume is useful for the design of rotating biological contactors (RBC and for comparison with the other processes such as activated sludge or oxidation ponds. The present study puts emphasis on the significance of this control or design parameter because it allows direct comparison of the RBC system's performance when operated under various circumstances and with different kinds of wastewater. The results of the paper proved that, the COD removal in rotating biological contactor systems is a function of the organic loading rate. However, each of the wastewater concentration and flow rate are also influence on the system efficiency but theirs impact can be combined by the effect of organic loading. The majority of COD removal (40-85 % of the total removal depending on the organic loading applied occurs in the first stages of the system. There is a strong correlation between the organic loading and the concentration of the suspended solids in the rotating biological contactor basin. At higher loadings higher concentrations noted. At a loading of about, (24 g/m2.d suspended solids were 225, 125, 35, and 25 mg/L in the first, second, third and, the fourth stage respectively. To achieve an effluent quality of (BOD < 25 mg/L, COD < 60 mg/L, the system must be operated on organic loadings of about (22 gBOD/m2.d and 65 gCOD/m2.d respectively. For nitrification process, the system must be designed to operate at organic loading of about (10 g/m2.d or less and, the reactor or basin volume should be designed to achieve a hydraulic loading of about (40 L/m2.d or less.

  19. Uniform random number generators (United States)

    Farr, W. R.


    Methods are presented for the generation of random numbers with uniform and normal distributions. Subprogram listings of Fortran generators for the Univac 1108, SDS 930, and CDC 3200 digital computers are also included. The generators are of the mixed multiplicative type, and the mathematical method employed is that of Marsaglia and Bray.

  20. Biological effects due to weak magnetic field on plants (United States)

    Belyavskaya, N. A.


    magnetic field may cause different biological effects at the cellular, tissue and organ levels. They may be functionally related to systems that regulate plant metabolism including the intracellular Ca 2+ homeostasis. However, our understanding of very complex fundamental mechanisms and sites of interactions between weak magnetic fields and biological systems is still incomplete and still deserve strong research efforts.


    Gibert, K K; Karasev, A K; Marasanov, A V; Stekhin, A A; Iakovleva, G V


    There have been performed the studies of the dimensional parameters of peroxide associates in drinking water, per- forming regulatory functions in cellular metabolism, that determine the character of the biological response of the human body to drinking water The direction of action of peroxide associates type Σ [(HO2-(*) ... OH-(*) (H2O) tp)]q, (where (H2O) tp is an associate with the tetragonal structure (Walrafen pentamer Is ice VI), q is the degree of association p--parameter of ion coordination) on the cellular structures of the organism is associated with their quantum properties, determining the macroscopic parameters of the electron wave packets. Research has confirmed the addressness of the nonlocal entering electron to certain cellular structures of the body, which is determined by the structural similarity of centers of condensation of electrons in the cells of systems and organs of the body with the parameters of the electron wave packets in the associates. Methodology for the estimation of the orientation of biological effect of the drinking water to the systems of the body on the base of the analysis of variations in heart rhythm under non-contact influence of water on the human body and its relationship with the dimensional parameters and peroxide activity of associates in drinking water can be suggested for the implementation of screening tests for drinking water quality, taking into account both the individualfeatures of responses of body systems to drinking water and its group action.

  2. Biological vs. physical mixing effects on benthic food web dynamics.

    Directory of Open Access Journals (Sweden)

    Ulrike Braeckman

    Full Text Available Biological particle mixing (bioturbation and solute transfer (bio-irrigation contribute extensively to ecosystem functioning in sediments where physical mixing is low. Macrobenthos transports oxygen and organic matter deeper into the sediment, thereby likely providing favourable niches to lower trophic levels (i.e., smaller benthic animals such as meiofauna and bacteria and thus stimulating mineralisation. Whether this biological transport facilitates fresh organic matter assimilation by the metazoan lower part of the food web through niche establishment (i.e., ecosystem engineering or rather deprives them from food sources, is so far unclear. We investigated the effects of the ecosystem engineers Lanice conchilega (bio-irrigator and Abra alba (bioturbator compared to abiotic physical mixing events on survival and food uptake of nematodes after a simulated phytoplankton bloom. The (13C labelled diatom Skeletonema costatum was added to 4 treatments: (1 microcosms containing the bioturbator, (2 microcosms containing the bio-irrigator, (3 control microcosms and (4 microcosms with abiotic manual surface mixing. Nematode survival and subsurface peaks in nematode density profiles were most pronounced in the bio-irrigator treatment. However, nematode specific uptake (Δδ(13C of the added diatoms was highest in the physical mixing treatment, where macrobenthos was absent and the diatom (13C was homogenised. Overall, nematodes fed preferentially on bulk sedimentary organic material rather than the added diatoms. The total C budget (µg C m(-2, which included TO(13C remaining in the sediment, respiration, nematode and macrobenthic uptake, highlighted the limited assimilation by the metazoan benthos and the major role of bacterial respiration. In summary, bioturbation and especially bio-irrigation facilitated the lower trophic levels mainly over the long-term through niche establishment. Since the freshly added diatoms represented only a limited food

  3. Strategy Uniform Crossover Adaptation Evolution in a Minority Game

    Institute of Scientific and Technical Information of China (English)

    杨伟松; 汪秉宏; 全宏俊; 胡进锟


    We propose a new adaptation minority game for understanding the complex dynamical behaviour characterized by agent interactions competing limited resources in many natural and social systems. Intelligent agents may modify a part of their strategies periodically, depending on the strategyperformances. In the present model, the strategies will be updated according to a uniform-crossover variation process inspired by genetic evolution algorithm in biology. The performances of the agents in our model are calculated for different parameter conditions. It has been found that the new system may evolve via the strategy uniform crossover adaptation mechanism into a frozen equilibrium state in which the performance of the system may reach the best limit, implying the strongest cooperation among agents and the most effective utilization of the social resources.

  4. Effect of Different Uniform Temperature with Thickness-Wise Linear Temperature Gradient on Interfacial Stresses of a Bi-Material Assembly

    Directory of Open Access Journals (Sweden)

    D. Sujan


    Full Text Available Problem statement: The thermal mismatch induced interfacial stresses are one of the major reliability issues in electronic packaging and composite materials. Consequently an understanding of the nature of the interfacial stresses under different temperature conditions is essential in order to eliminate or reduce the risk of structural and functional failure. Approach: In this analysis, a model was proposed for the shearing and peeling stresses occurring at the interface of two bonded dissimilar materials with the effect of different uniform temperatures in the layers. The model was then upgraded by accounting thickness wise linear temperature gradients in the layers using two temperature drop ratios. The upgraded models were then compared with the existing uniform temperature model. The proposed model can be seen as a more generalized form to predict interfacial stresses at different temperature conditions that may occur in the layers. Results: The results were presented for an electronic bi-material package consisting of die and die-attach. Conclusion: The numerical simulation is in a good matching agreement with analytical results.

  5. 21 CFR 601.26 - Reclassification procedures to determine that licensed biological products are safe, effective... (United States)


    ... licensed biological products are safe, effective, and not misbranded under prescribed, recommended, or... Reclassification procedures to determine that licensed biological products are safe, effective, and not misbranded... for the reclassification of all biological products that have been classified into Category IIIA....

  6. Reactive Carbonyl Species In Vivo: Generation and Dual Biological Effects

    Directory of Open Access Journals (Sweden)

    Halyna M. Semchyshyn


    Full Text Available Reactive carbonyls are widespread species in living organisms and mainly known for their damaging effects. The most abundant reactive carbonyl species (RCS are derived from oxidation of carbohydrates, lipids, and amino acids. Chemical modification of proteins, nucleic acids, and aminophospholipids by RCS results in cytotoxicity and mutagenicity. In addition to their direct toxicity, modification of biomolecules by RCS gives rise to a multitude of adducts and cross links that are increasingly implicated in aging and pathology of a wide range of human diseases. Understanding of the relationship between metabolism of RCS and the development of pathological disorders and diseases may help to develop effective approaches to prevent a number of disorders and diseases. On the other hand, constant persistence of RCS in cells suggests that they perform some useful role in living organisms. The most beneficial effects of RCS are their establishment as regulators of cell signal transduction and gene expression. Since RCS can modulate different biological processes, new tools are required to decipher the precise mechanisms underlying dual effects of RCS.

  7. Effect of choline carboxylate ionic liquids on biological membranes. (United States)

    Rengstl, Doris; Kraus, Birgit; Van Vorst, Matthew; Elliott, Gloria D; Kunz, Werner


    Choline carboxylates, ChCm, with m=2-10 and choline oleate are known as biocompatible substances, yet their influence on biological membranes is not well-known, and the effect on human skin has not previously been investigated. The short chain choline carboxylates ChCm with m=2, 4, 6 act as hydrotropes, solubilizing hydrophobic compounds in aqueous solution, while the longer chain choline carboxylates ChCm with m=8, 10 and oleate are able to form micelles. In the present study, the cytotoxicity of choline carboxylates was tested using HeLa and SK-MEL-28 cells. The influence of these substances on liposomes prepared from dipalmitoylphosphatidylcholine (DPPC) was also evaluated to provide insights on membrane interactions. It was observed that the choline carboxylates with a chain length of m>8 distinctly influence the bilayer, while the shorter ones had minimal interaction with the liposomes.

  8. Behavioural biology: an effective and relevant conservation tool. (United States)

    Buchholz, Richard


    'Conservation behaviour' is a young discipline that investigates how proximate and ultimate aspects of the behaviour of an animal can be of value in preventing the loss of biodiversity. Rumours of its demise are unfounded. Conservation behaviour is quickly building a capacity to positively influence environmental decision making. The theoretical framework used by animal behaviourists is uniquely valuable to elucidating integrative solutions to human-wildlife conflicts, efforts to reintroduce endangered species and reducing the deleterious effects of ecotourism. Conservation behaviourists must join with other scientists under the multidisciplinary umbrella of conservation biology without giving up on their focus: the mechanisms, development, function and evolutionary history of individual differences in behaviour. Conservation behaviour is an increasingly relevant tool in the preservation of nature.

  9. Biological effects and equivalent doses in radiotherapy: a software solution

    CERN Document Server

    Voyant, Cyril; Roustit, Rudy; Biffi, Katia; Marcovici, Celine Lantieri


    The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers.

  10. Biological Effects on Fruit Fly by N+ ion Beam Implantation

    Institute of Scientific and Technical Information of China (English)


    Mutation induced by low energy ion beam implantation has beenapplied widely both in plants and microbes. However, due to the vacuum limitation, such ion implantation into animals was never studied except for silkworm. In this study, Pupae of fruit fly were irradiated with different dosage N+ ions at energy 20 KeV to study the biological effect of ion beam on animal. The results showed a saddle-like curve exists between incubate rate and dosage. Damage of pupae by ion beam implantation was observed using scanning electron microscope. Some individuals with incomplete wing were obtained after implantation but no similar character was observed in their offspring. Furthermore, about 5.47% mutants with wide variation appeared in M1 generation. Therefore, ion beam implantation could be widely used for mutation breeding.

  11. Hydrodynamic collective effects of active proteins in biological membranes (United States)

    Koyano, Yuki; Kitahata, Hiroyuki; Mikhailov, Alexander S.


    Lipid bilayers forming biological membranes are known to behave as viscous two-dimensional fluids on submicrometer scales; usually they contain a large number of active protein inclusions. Recently, it was shown [A. S. Mikhailov and R. Kapral, Proc. Natl. Acad. Sci. USA 112, E3639 (2015), 10.1073/pnas.1506825112] that such active proteins should induce nonthermal fluctuating lipid flows leading to diffusion enhancement and chemotaxislike drift for passive inclusions in biomembranes. Here, a detailed analytical and numerical investigation of such effects is performed. The attention is focused on the situations when proteins are concentrated within lipid rafts. We demonstrate that passive particles tend to become attracted by active rafts and are accumulated inside them.

  12. Interaction mechanisms and biological effects of static magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Tenforde, T.S.


    Mechanisms through which static magnetic fields interact with living systems are described and illustrated by selected experimental observations. These mechanisms include electrodynamic interactions with moving, ionic charges (blood flow and nerve impulse conduction), magnetomechanical interactions (orientation and translation of molecules structures and magnetic particles), and interactions with electronic spin states in charge transfer reactions (photo-induced electron transfer in photosynthesis). A general summary is also presented of the biological effects of static magnetic fields. There is convincing experimental evidence for magnetoreception mechanisms in several classes of lower organisms, including bacteria and marine organisms. However, in more highly evolved species of animals, there is no evidence that the interactions of static magnetic fields with flux densities up to 2 Tesla (1 Tesla [T] = 10{sup 4} Gauss) produce either behavioral or physiolocical alterations. These results, based on controlled studies with laboratory animals, are consistent with the outcome of recent epidemiological surveys on human populations exposed occupationally to static magnetic fields.

  13. Effect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes

    Directory of Open Access Journals (Sweden)

    Attila Gergely Végh


    Full Text Available Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues. Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet. We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoyl phosphatidylcholine (DPPC and on purple membrane of Halobacterium salinarum. Concentration dependent interaction of the peptide and membranes was found in case of DPPC resulting the destruction of the membrane. Purple membrane was much more resistant against indolicidin, probably due to its high protein content. Indolicidin preferred the border of membrane disks, where the lipids are more accessible. These data suggest that the atomic force microscope is a powerful tool in the study of indolicidin-membrane interaction.

  14. [The biological effect of fireproof ceramic fibers--literature review]. (United States)

    Krajnow, A


    The work presents reports, selected from the world literature, on the studies of biological effect of refractory ceramic fibres, carried out on experimental animals. The discrepancy between the results of studies performed may originate from differences in the distribution of fibre sizes or the durability of fibres in the organism and their surface properties which, in turn, depend on the chemical composition of fibres. In all studies discussed, ceramic fibres generally activated macrophages and they were characterised by a moderate fibrotic activity. A statistically significant increase in the incidence of tumor (mesothelioma) observed in several very important experimental studies may suggest that some types of refractory ceramic fibres show a similar carcinogenic potential to that of natural asbestos: crocidolite or chrysotile.

  15. Investigation on inhibition of biological effects of endothelin

    Institute of Scientific and Technical Information of China (English)

    田青; 赵东; 张继峰; 高连如; 刘胜昔; 杨军; 苏静怡; 张肇康; 汤健; 唐朝枢


    The effects of a series of substances on the biological function of endothelin (ET) are reported. The substances used are: synthetic inhibitors of endothelium derived relaxing factors (EDRFs), inhibitor of big-endothelin converting enzyme phosphoramidon, antiserum of endothelin, antagonists of endothelin A receptor BQ123 and JKC301, and two Chinese anti-snake venom herb medicines Lobelia radians Thumb and Taris polyphylla Smith var. chinensis (Franch) Hara. The results showed that inhibiting the production of nitric oxide (NO) could stimulate ET release from vascular endothelium, elevate plasma ET and increase blood pressure. These changes could be reversed by L-arginine (L-Arg), the substrate of nitric oxide synthase (NOS). The amount of ET released by arterial endothelium could be increased or inhibited by inhibiting or stimulating the synthesis of prostacyclin (PGI2). The plasma ET level and blood pressure in both SHR and WKY rats could be decreased by giving phosphoramidon (PhR). The above results i

  16. Effect of Computer Animations Upon Student's Achievement of Biology Education

    Directory of Open Access Journals (Sweden)

    Mehmet YAKIŞAN


    Full Text Available The prime purpose of this study is to investigate the effect of computer animation supported biology education upon students’ academic achievement. The study was participated by 97 pre service teachers studying in the first year of university. The data were collected by “Cell Achievement Test” There were control and experimental groups formed and the experimental group was taught with computer animations related with diffusion, osmosis, active transport, protein synthesis, mitosis and meiosis phenomena taking place in cell while the control group was taught with traditional method based on question and answer process. The data obtained were evaluated by t- test and represented by tables and graphs. The results of the study indicated significant differences between the academic achievements of control and experimental groups. The difference is in the favor of the experimental group which revealed the fact the computer animations caused a significant increase in the academic achievements of the students.

  17. Biological Effectiveness and Application of Heavy Ions in Radiation Therapy Described by a Physical and Biological Model

    DEFF Research Database (Denmark)

    Olsen, Kjeld J.; Hansen, Johnny W.

    A description is given of the physical basis for applying track structure theory in the determination of the effectiveness of heavy-ion irradiation of single- and multi-hit target systems. It will be shown that for applying the theory to biological systems the effectiveness of heavy-ion irradiation...... simultaneously in therapy....

  18. Biological effects due to weak magnetic fields on plants (United States)

    Belyavskaya, N.

    In the evolution process, living organisms have experienced the action of the Earth's magnetic field (MF) that is a natural component of our environment. It is known that a galactic MF induction does not exceed 0.1 nT, since investigations of weak magnetic field (WMF) effects on biological systems have attracted attention of biologists due to planning long-term space flights to other planets where the magnetizing force is near 10-5 Oe. However, the role of WMF and its influence on organisms' functioning are still insufficiently investigated. A large number of experiments with seedlings of different plant species placed in WMF has found that the growth of their primary roots is inhibited during the early terms of germination in comparison with control. The proliferation activity and cell reproduction are reduced in meristem of plant roots under WMF application. The prolongation of total cell reproductive cycle is registered due to the expansion of G phase in1 different plant species as well as of G phase in flax and lentil roots along with2 relative stability of time parameters of other phases of cell cycle. In plant cells exposed to WMF, the decrease in functional activity of genome at early prereplicate period is shown. WMF causes the intensification in the processes of proteins' synthesis and break-up in plant roots. Qualitative and quantitative changes in protein spectrum in growing and differentiated cells of plant roots exposed to WMF are revealed. At ultrastructural level, there are observed such ultrastructural peculiarities as changes in distribution of condensed chromatin and nucleolus compactization in nuclei, noticeable accumulation of lipid bodies, development of a lytic compartment (vacuoles, cytosegresomes and paramural bodies), and reduction of phytoferritin in plastids in meristem cells of pea roots exposed to WMF. Mitochondria are the most sensitive organelle to WMF application: their size and relative volume in cells increase, matrix is electron

  19. Effect of a biological activated carbon filter on particle counts

    Institute of Scientific and Technical Information of China (English)

    Su-hua WU; Bing-zhi DONG; Tie-jun QIAO; Jin-song ZHANG


    Due to the importance of biological safety in drinking water quality and the disadvantages which exist in traditional methods of detecting typical microorganisms such as Cryptosporidium and Giardia,it is necessary to develop an alternative.Particle counts is a qualitative measurement of the amount of dissolved solids in water.The removal rate of particle counts was previously used as an indicator of the effectiveness of a biological activated carbon(BAC)filter in removing Cryptosporidium and Giardia.The particle counts in a BAC filter effluent over one operational period and the effects of BAC filter construction and operational parameters were investigated with a 10 m3/h pilot plant.The results indicated that the maximum particle count in backwash remnant water was as high as 1296 count/ml and it needed about 1.5 h to reduce from the maximum to less than 50 count/ml.During the standard filtration period,particle counts stay constant at less than 50 count/ml for 5 d except when influ-enced by sand filter backwash remnant water.The removal rates of particle counts in the BAC filter are related to characteristics of the carbon.For example,a columned carbon and a sand bed removed 33.3% and 8.5% of particles,respectively,while the particle counts in effluent from a cracked BAC filter was higher than that of the influent.There is no significant difference among particle removal rates with different filtration rates.High post-ozone dosage(>2 mg/L)plays an important role in particle count removal;when the dosage was 3 mg/L,the removal rates by carbon layers and sand beds decreased by 17.5% and increased by 9.5%,respectively,compared with a 2 mg/L dosage.

  20. Uniform Requirements for Manuscripts

    Institute of Scientific and Technical Information of China (English)


    @@ Introduction The Uniform requirements are instructions to authors on how to prepare manuscripts.If authors prepare their manuscripts in the style specified in these requirements, editors of the participating journals will not return the manuscripts for changes in style before considering them for publication.In the publishing process, however, the journals may alter accepted manuscripts to conform with details of their publication styles.

  1. Thomas Precession by Uniform Acceleration

    CERN Document Server

    Pardy, Miroslav


    We determine the nonlinear transformations between coordinate systems which are mutually in a constant symmetrical accelerated motion. The maximal acceleration limit follows from the kinematical origin and it is an analogue of the maximal velocity in special relativity. We derive the dependence of mass, length, time, Doppler effect, Cherenkov effect and transition radiation angle on acceleration as an analogue phenomena in special theory of relativity. The last application of our method is the Thomas precession by uniform acceleration with the possible role in the modern physics and cosmology. The comparison of derived results with other relativistic methods is necessary.

  2. Deposition uniformity inspection in IC wafer surface (United States)

    Li, W. C.; Lin, Y. T.; Jeng, J. J.; Chang, C. L.


    This paper focuses on the task of automatic visual inspection of color uniformity on the surface of integrated circuits (IC) wafers arising from the layering process. The oxide thickness uniformity within a given wafer with a desired target thickness is of great importance for modern semiconductor circuits with small oxide thickness. The non-uniform chemical vapor deposition (CVD) on a wafer surface will proceed to fail testing in Wafer Acceptance Test (WAT). Early detection of non-uniform deposition in a wafer surface can reduce material waste and improve production yields. The fastest and most low-priced inspection method is a machine vision-based inspection system. In this paper, the proposed visual inspection system is based on the color representations which were reflected from wafer surface. The regions of non-uniform deposition present different colors from the uniform background in a wafer surface. The proposed inspection technique first learns the color data via color space transformation from uniform deposition of normal wafer surfaces. The individual small region statistical comparison scheme then proceeds to the testing wafers. Experimental results show that the proposed method can effectively detect the non-uniform deposition regions on the wafer surface. The inspection time of the deposited wafers is quite compatible with the atmospheric pressure CVD time.

  3. The effect of green tea on radiation-induced late biological effect in mice

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Ho; Kim, Se Ra; Lee, Hae June; Jo, Sung Kee [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)


    This study was performed to determine the effect of Green tea on the late biological effect of mice irradiated with 3 Gy of gamma-radiation. There were various findings including hematopoietic and lymphoid tumor, lung cancer, ovarian cancer and cancer of other lesions. Further studies are needed to characterize better the protective nature of active compounds.

  4. Effects of transient and non-uniform distribution of heat flux on intensity of heat transfer and burnout conditions in the channels of nuclear reactors

    Energy Technology Data Exchange (ETDEWEB)

    Vitaly Osmachkin [Russian Research Center ' Kurchatov Institute' 1, Kurchatov sq, Moscow 123182 (Russian Federation)


    Full text of publication follows: The influence of power transient, changes of flow rate, inlet temperatures or pressure in cores of nuclear reactors on heat transfer and burnout conditions in channels depend on rate of such violations. Non-uniform distribution of the heat flux is also important factor for heat transfer and development of crisis phenomenon. Such effects may be significant for NPPs safety. But they have not yet generally accepted interpretation. Steady state approach is often recommended for use in calculations. In the paper a review of experimental observed so-called non-equilibrium effects is presented. The effects of space and time factors are displaying due delay in reformation turbulence intensity, velocity, temperatures or void fraction profiles, water film flow on the surface of heated channels. For estimation of such effect different methods are used. Modern computer codes based on two or three fluids approaches are considered as most effective. But simple and clear correlations may light up the mechanics of effects on heat transfer and improve general understanding of scale and significance of the transient events. In the paper the simplified methods for assessment the influence of lags in the development of distributions of parameters of flow, the relaxation of temporal or space violations are considered. They are compared with more sophisticated approaches. Velocities of disturbance fronts moving along the channels are discussed also. (author)

  5. Effect of Uniform Decoration of Ag2S Nanoparticles on Physical Properties of Granular TiO2 Thin Films Synthesized by Using Spin Coating Technique

    Directory of Open Access Journals (Sweden)

    R.A. Wagh


    Full Text Available In this work, we report the effect of uniform decoration of silver sulphide (Ag2S nanoparticles on physical properties of titanium dioxide (TiO2 nanocrystalline thin films synthesized by using a spin coating technique by preparing TiO2 gel using P-25 TiO2, ethanol, acetyl acetone and p-hydroxybenzoic acid. Chemical bath deposited layer of Ag2S particles enhance the properties of TiO2 nanocrystalline thin films. The optical study reveals that the absorption edge shifts towards the visible region compared with the pure TiO2 thin film due to the incorporation of Ag2S nanoparticles into TiO2 nanocrystalline thin films.

  6. Effect of heat radiation in a Walter’s liquid B fluid over a stretching sheet with non-uniform heat source/sink and elastic deformation

    Directory of Open Access Journals (Sweden)

    A.K. Abdul Hakeem


    Full Text Available In this present article heat transfer in a Walter’s liquid B fluid over an impermeable stretching sheet with non-uniform heat source/sink, elastic deformation and radiation are reported. The basic boundary layer equations for momentum and heat transfer, which are non-linear partial differential equations, are converted into non-linear ordinary differential equations by means of similarity transformation. The dimensionless governing equations for this investigation are solved analytically using hyper geometric functions. The results are carried out for prescribed surface temperature (PST and prescribed power law surface heat flux (PHF. The effects of viscous dissipation, Prandtl number, Eckert number, heat source/sink parameter with elastic deformation and radiation are shown in the several plots and addressed.

  7. Mutagenic Effects of Iron Oxide Nanoparticles on Biological Cells. (United States)

    Dissanayake, Niluka M; Current, Kelley M; Obare, Sherine O


    In recent years, there has been an increased interest in the design and use of iron oxide materials with nanoscale dimensions for magnetic, catalytic, biomedical, and electronic applications. The increased manufacture and use of iron oxide nanoparticles (IONPs) in consumer products as well as industrial processes is expected to lead to the unintentional release of IONPs into the environment. The impact of IONPs on the environment and on biological species is not well understood but remains a concern due to the increased chemical reactivity of nanoparticles relative to their bulk counterparts. This review article describes the impact of IONPs on cellular genetic components. The mutagenic impact of IONPs may damage an organism's ability to develop or reproduce. To date, there has been experimental evidence of IONPs having mutagenic interactions on human cell lines including lymphoblastoids, fibroblasts, microvascular endothelial cells, bone marrow cells, lung epithelial cells, alveolar type II like epithelial cells, bronchial fibroblasts, skin epithelial cells, hepatocytes, cerebral endothelial cells, fibrosarcoma cells, breast carcinoma cells, lung carcinoma cells, and cervix carcinoma cells. Other cell lines including the Chinese hamster ovary cells, mouse fibroblast cells, murine fibroblast cells, Mytilus galloprovincialis sperm cells, mice lung cells, murine alveolar macrophages, mice hepatic and renal tissue cells, and vero cells have also shown mutagenic effects upon exposure to IONPs. We further show the influence of IONPs on microorganisms in the presence and absence of dissolved organic carbon. The results shed light on the OPEN ACCESS Int. J. Mol. Sci. 2015, 16 23483 transformations IONPs undergo in the environment and the nature of the potential mutagenic impact on biological cells.

  8. Origination of gamma-ray burst pulses associated with the Doppler effect of spherical fireballs or uniform jet

    Institute of Scientific and Technical Information of China (English)

    Lu Rui-Jing; Qin Yi-Ping; Zhang Fu-Wen


    Ryde and Petrosian have pointed out that the rise phases of gamma-ray burst (GRB) pulses originate from the widths of the intrinsic pulses and their decay phases are determined by the curvature effect of the expanding fireball surface based on their simplified formula. In this paper we investigate in detail the issue based on the formula in Ref.[20], which is derived based on a model of highly symmetric expanding fireballs, where the Doppler effect is the key factor to be concerned about, and no terms are omitted in their derivation. Our analyses show that the decay phases of the observed pulses originate from the contributions from both the curvature effect of the expanding fireball and the two timescales of the local pulses, and the rise phases of the observed pulses only come from the two timescales of the local pulses. Associated with a local pulse with both rise and decay portions, the light curve of GRBs in the rise portion is expected to undergo a concave phase and then a convex one, whereas that in the decay portion is expected to evolve by an opposite process. And the ratio of the concave timescale to the convex one in the rise phase of the observed pulse linearly increases with the ratio of the rising timescale to the decay one of the local pulse (γrd), whereas the ratio of the convex timescale to the concave timescale in its decay phase linearly decreases with γrd. The two correlations are independent of the local pulse forms and the rest-frame radiation forms. But the different forms of local pulses and the different values of γrd gives rise to the diversity of the light curve pulse shapes. We test a sample of 86 GRB pulses detected by the BATSE instrument on board the Compton Gamma Ray Observatory and find that the characteristics do exist in the light curve of GRBs.

  9. Radiation effect on MHD free-convection flow of a gas at a stretching surface with a uniform free stream

    Directory of Open Access Journals (Sweden)

    Ahmed Y. Ghaly


    Full Text Available We investigate the problem of free convection heat transfer near an isothermal stretching sheet. This has been done under the simultaneous action of buoyancy, radiation, and transverse magnetic field. The governing equations are solved by the shooting method. The velocity and temperature functions are represented graphically for various values of the flow parameters: radiation parameter F, free convection parameter Gr, magnetic parameter M, Prandtl number Pr, and the parameter of relative difference between the temperature of the sheet, and the temperature far away from the sheet r. The effects of the radiation and magnetic field parameters on the shear stress and heat flux are discussed.

  10. Effects of in-plane magnetic field on the transport of 2D electron vortices in non-uniform plasmas (United States)

    Angus, Justin; Richardson, Andrew; Schumer, Joseph; Pulsed Power Team


    The formation of electron vortices in current-carrying plasmas is observed in 2D particle-in-cell (PIC) simulations of the plasma-opening switch. In the presence of a background density gradient in Cartesian systems, vortices drift in the direction found by crossing the magnetic field with the background density gradient as a result of the Hall effect. However, most of the 2D simulations where electron vortices are seen and studied only allow for in-plane currents and thus only an out-of-plane magnetic field. Here we present results of numerical simulations of 2D, seeded electron vortices in an inhomogeneous background using the generalized 2D electron-magneto-hydrodynamic model that additionally allows for in-plane components of the magnetic field. By seeding vortices with a varying axial component of the velocity field, so that the vortex becomes a corkscrew, it is found that a pitch angle of around 20 degrees is sufficient to completely prevent the vortex from propagating due to the Hall effect for typical plasma parameters. This work is supported by the NRL Base Program.

  11. Effect of Sedimentation on Treated Greywater Through Rotating Biological Contactor

    Directory of Open Access Journals (Sweden)

    Ashfaque Ahmed Pathan


    Full Text Available The aim of this paper was to study the effect of sedimentation on effluent of a pilot scale Rotating Biological Contactor (RBC. The treated greywater was given three hours sedimentation period and samples were analyzed to observe the effect of sedimentations under variousflow rates. Greywater was separated from the black water and collected in the collection tank and then it was pumped to an overhead tank. This tank supplied a regulated continuous flow of greywater into the RBC chamber at the required flow rate ranging between 0.28 to 1.89 l/min. A pilot scale RBC simulator was developed and placed outside a hall of residence at National Center of Excellence in Analytical Chemistry, Sindh University, Jamshoro. The simulator was operated at the rotational speed of discs of 1.7 rpm. The disks were uneven and textured so as to encourage growth of bacteria on them. These discs were immersed about 40 percent in the greywater.The simulator produced effluent of significant quality and was found efficient in removal of BOD5, COD and TSS as 85%, 68% and 95% respectively.

  12. New Scientific Pearl about Biologic Effect of Ionizing Radiation

    Directory of Open Access Journals (Sweden)

    S. A. Alamdaran


    Full Text Available Soon after the discovery of X-ray by Rontgen in 1895, it became evident that radiation can cause some somatic damage to tissues. The hazards of X-ray exposure were clearly known when many large hospitals had radiology departments. The greatest increased in knowledge about X-ray risks had accrued from the dropping of the two atomic bombs in Japan in 1945 and some other atomic accident. For example, among the Japanese bomb survivors from Hiroshima and Nagasaki, there have been about 400 extra cancer deaths. These were the origin of radiology personnel and people fear from radiation exposure and resistant in against simple X-ray exam (radiophobia. However, new scientific data on the effects radiation on survivors, especially about biologic effect of ionizing rays, background radiation exposure, amount of endogenous radiation, hormosis phenomenon and comparison radiation risk with other risk over lifetime are still being continuously revised and risk estimates updated. Fundamentally, this risk is much"nlower than whatever already estimated and it is insignificant in diagnostic domain. Better perception of physician from these instances help to prevent of false radiophobia and to make proper use of diagnostic and therapeutic advantages of ionizing beam.

  13. [Effects of decitabine on biological behavior of U266 cells]. (United States)

    Wang, Mei-Fang; Yang, Lin-Hua; Dong, Chun-Xia; Zhang, Rui-Juan; Zhang, Jian-Hua; Guo, Zhi-Ping; Chen, Jian-Fang; Zhagn, Li; Feng, Da-Wei


    This study was aimed to explore the effects of decitabine on the biological behaviour of U266 cells in vitro so as to provide a new thinking and experiment basis, as well as new evidences for the pathogenesis of multiple myeloma. MTT and colony formation assays were used to evaluate the impact of decitabine on the ability of proliferation of U266 cells; flow cytometry was used to analyze the cell distribution in cell cycle; transwell chamber and matrigel assays were used to observe the ability of migration and invasion. The results indicated that decitabine could significantly suppress the proliferation of U266 cells in time-and dose-dependent manners. The flow cytometric analysis demonstrated that the cells in G(0)-G(1) phase significantly increased while the cells in S and G(2)/M phase decreased. The migration and matrigel invading tests showed that the number of cells moving into under chamber of transwell decreased after U266 cells treated with decitabine. It is concluded that decitabine may act as an effective drug for MM by inhibiting the proliferation, migration and invasion ability, and the specific mechanism needs to be deeply explored.

  14. Effects of non-uniform interfacial tension in small Reynolds number flow past a spherical liquid drop

    Indian Academy of Sciences (India)

    D P Mason; G M Moremedi


    A singular perturbation solution is given for small Reynolds number flow past a spherical liquid drop. The interfacial tension required to maintain the drop in a spherical shape is calculated. When the interfacial tension gradient exceeds a critical value, a region of reversed flow occurs on the interface at the rear and the interior flow splits into two parts with reversed circulation at the rear. The magnitude of the interior fluid velocity is small, of order the Reynolds number. A thin transition layer attached to the drop at the rear occurs in the exterior flow. The effects could model the stagnant cap which forms as surfactant is added but the results apply however the variability in the interfacial tension might have been induced.

  15. Effect of non-uniform magnetic field on crystal growth by floating-Zone method in microgravity

    Institute of Scientific and Technical Information of China (English)

    LI; Kai(


    [1]Markov, E. V., Antropov, V. Yu, Biryukov, V. M. et al., Space materials for microelectronics, in Proceedings of the Joint Xth European and VIth Russian Symposium on Physical Sciences in Microgravity, St. Petersburg, Russia (eds. Av-duyevsky, V. S., Polezhaev, V. I.), Moscow: RAS, 1997, Vol. 2, 11-20.[2]Croll, A., Dold, P., Benz, K. W., Segregation in Si floating-zone crystals grown under microgravity and in a magnetic field, J. Crystal Growth, 1994, 137: 95-101.[3]Leon de, N., Guldberg, J., Sailing, J. , Growth of homogeneous high resistivity FZ silicon crystals under magnetic field bias, J. Crystal Growth, 1981, 55: 406-408.[4]Robertson, D. G., O' connor Jr., D. J., Magnetic field effects on float-zone Si crystal growth: strong axial fields, J. Crystal Growth, 1986, 76: 111-122.[5]Series, R. W., Hurle, D. T. J., The use of magnetic field in semiconductor crystal growth, J. Crystal Growth, 1991, 113:305-328.[6]Lan, C. W. , Effect of axisymmetric magnetic fields on radial dopant segregation of floating-zone silicon growth in a mirror fur-nace, J. Crystal Growth, 1996, 169: 269-278.[7]Li, K., Hu, W. R. , Numerical simulation of magnetic field design for damping thermocapillary convection in a floating half zone, J. Crystal Growth, 2001, 222: 677-684.[8]Li. K., Hu, W. R., Magnetic design for crystal growth, 3rd International Workshop on Modeling in Crystal Growth, New York, USA, 2000, to be published in J. Crystal Growth.[9]Patankar, S. V., Advanced Computational Heat Transfer and Fluid Flow, Graduate Student Course 8352 of Mechanical Engi-neering Department at Univ. of Minnesota, USA.

  16. 21 CFR 601.25 - Review procedures to determine that licensed biological products are safe, effective, and not... (United States)


    ... biological products are safe, effective, and not misbranded under prescribed, recommended, or suggested... determine that licensed biological products are safe, effective, and not misbranded under prescribed, recommended, or suggested conditions of use. For purposes of reviewing biological products that have...

  17. The biological effects of ionising radiation on Crustaceans: A review

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, Neil; Lerebours, Adélaïde [Institute of Marine Sciences, School of Biological Sciences, University of Portsmouth, Ferry Road, Portsmouth, Hampshire PO4 9LY (United Kingdom); Smith, Jim T. [School of Earth & Environmental Sciences, University of Portsmouth, Burnaby Building, Burnaby Road, Portsmouth, Hampshire PO1 3QL (United Kingdom); Ford, Alex T., E-mail: [Institute of Marine Sciences, School of Biological Sciences, University of Portsmouth, Ferry Road, Portsmouth, Hampshire PO4 9LY (United Kingdom)


    Highlights: • We comprehensively review the effects of ionising radiation in crustaceans. • Current environmental radioprotection levels found to be inadequate in some cases. • Mutation is shown to be a sensitive endpoint of radiation exposure. • Lowest observed effect dose rate varies by orders of magnitude. - Abstract: Historic approaches to radiation protection are founded on the conjecture that measures to safeguard humans are adequate to protect non-human organisms. This view is disparate with other toxicants wherein well-developed frameworks exist to minimise exposure of biota. Significant data gaps for many organisms, coupled with high profile nuclear incidents such as Chernobyl and Fukushima, have prompted the re-evaluation of our approach toward environmental radioprotection. Elucidating the impacts of radiation on biota has been identified as priority area for future research within both scientific and regulatory communities. The crustaceans are ubiquitous in aquatic ecosystems, comprising greater than 66,000 species of ecological and commercial importance. This paper aims to assess the available literature of radiation-induced effects within this subphylum and identify knowledge gaps. A literature search was conducted pertaining to radiation effects on four endpoints as stipulated by a number of regulatory bodies: mortality, morbidity, reproduction and mutation. A major finding of this review was the paucity of data regarding the effects of environmentally relevant radiation doses on crustacean biology. Extremely few studies utilising chronic exposure durations or wild populations were found across all four endpoints. The dose levels at which effects occur was found to vary by orders of magnitude thus presenting difficulties in developing phyla-specific benchmark values and reference levels for radioprotection. Based on the limited data, mutation was found to be the most sensitive endpoint of radiation exposure, with mortality the least sensitive

  18. Enhanced Biological Phosphorus Removal: Metabolic Insights and Salinity Effects

    NARCIS (Netherlands)

    Welles, L.


    Enhanced biological phosphorus removal (EBPR) is a biological process for efficient phosphate removal from wastewaters through intracellular storage of polyphosphate by polyphosphate-accumulating organisms (PAO) and subsequent removal of PAO from the system through wastage of sludge. In comparison t

  19. The effect of network biology on drug toxicology

    DEFF Research Database (Denmark)

    Gautier, Laurent; Taboureau, Olivier; Audouze, Karine Marie Laure


    it with bioinformatics. With this approach, the assessment of chemical safety can be done across multiple scales of complexity from molecular to cellular and system levels in human health. Network biology can be used at several levels of complexity. Areas covered: This review describes the strengths and limitations......Introduction: The high failure rate of drug candidates due to toxicity, during clinical trials, is a critical issue in drug discovery. Network biology has become a promising approach, in this regard, using the increasingly large amount of biological and chemical data available and combining...... of network biology. The authors specifically assess this approach across different biological scales when it is applied to toxicity. Expert opinion: There has been much progress made with the amount of data that is generated by various omics technologies. With this large amount of useful data, network...

  20. Uniform gradient expansions

    Energy Technology Data Exchange (ETDEWEB)

    Giovannini, Massimo, E-mail: [Department of Physics, Theory Division, CERN, 1211 Geneva 23 (Switzerland); INFN, Section of Milan-Bicocca, 20126 Milan (Italy)


    Cosmological singularities are often discussed by means of a gradient expansion that can also describe, during a quasi-de Sitter phase, the progressive suppression of curvature inhomogeneities. While the inflationary event horizon is being formed the two mentioned regimes coexist and a uniform expansion can be conceived and applied to the evolution of spatial gradients across the protoinflationary boundary. It is argued that conventional arguments addressing the preinflationary initial conditions are necessary but generally not sufficient to guarantee a homogeneous onset of the conventional inflationary stage.

  1. Collocation on uniform grids

    Energy Technology Data Exchange (ETDEWEB)

    Amore, Paolo; Saenz, Ricardo A; Salvo, Koen [Facultad de Ciencias, CUICBAS, Universidad de Colima, Bernal DIaz del Castillo 340 Colima, Colima (Mexico); Fernandez, Francisco M [INIFTA (UNLP, CCT La Plata-Conicet), Diag. 113 y 64 S/N, Sucursal 4, Casilla de Correo 16, 1900 La Plata (Argentina)], E-mail:, E-mail:, E-mail:, E-mail:


    In this paper we derive four sets of sinc-like functions, defined on a finite interval and obeying different boundary conditions. The functions in each set are orthogonal and their nodes are uniformly distributed on the interval. We have applied each set to solve a large class of eigenvalue equations, with different boundary conditions, both on finite intervals and on the real line, showing that precise numerical results can be obtained efficiently and rapidly. A comparison with results available in the literature is also performed.

  2. Uniform distribution of sequences

    CERN Document Server

    Kuipers, L


    The theory of uniform distribution began with Hermann Weyl's celebrated paper of 1916. In later decades, the theory moved beyond its roots in diophantine approximations to provide common ground for topics as diverse as number theory, probability theory, functional analysis, and topological algebra. This book summarizes the theory's development from its beginnings to the mid-1970s, with comprehensive coverage of both methods and their underlying principles.A practical introduction for students of number theory and analysis as well as a reference for researchers in the field, this book covers un

  3. The uniform electron gas

    CERN Document Server

    Loos, Pierre-François


    The uniform electron gas or UEG (also known as jellium) is one of the most fundamental models in condensed-matter physics and the cornerstone of the most popular approximation --- the local-density approximation --- within density-functional theory. In this article, we provide a detailed review on the energetics of the UEG at high, intermediate and low densities, and in one, two and three dimensions. We also report the best quantum Monte Carlo and symmetry-broken Hartree-Fock calculations available in the literature for the UEG and discuss the phase diagrams of jellium.

  4. Uniform gradient expansions

    Directory of Open Access Journals (Sweden)

    Massimo Giovannini


    Full Text Available Cosmological singularities are often discussed by means of a gradient expansion that can also describe, during a quasi-de Sitter phase, the progressive suppression of curvature inhomogeneities. While the inflationary event horizon is being formed the two mentioned regimes coexist and a uniform expansion can be conceived and applied to the evolution of spatial gradients across the protoinflationary boundary. It is argued that conventional arguments addressing the preinflationary initial conditions are necessary but generally not sufficient to guarantee a homogeneous onset of the conventional inflationary stage.

  5. Women in service uniforms

    Directory of Open Access Journals (Sweden)

    Hanna Karaszewska


    Full Text Available The article discusses the problems of women who work in the uniformed services with the particular emphasis on the performing of the occupation of the prison service. It presents the legal issues relating to equal treatment of men and women in the workplace, formal factors influencing their employment, the status of women in prison, and the problems of their conducting in the professional role. The article also presents the results of research conducted in Poland and all over the world, on the functioning of women in prison and their relations with officers of the Prison Service, as well as with inmates.

  6. A model of the radiation-induced bystander effect based on an analogy with ferromagnets. Application to modelling tissue response in a uniform field (United States)

    Vassiliev, O. N.


    We propose a model of the radiation-induced bystander effect based on an analogy with magnetic systems. The main benefit of this approach is that it allowed us to apply powerful methods of statistical mechanics. The model exploits the similarity between how spin-spin interactions result in correlations of spin states in ferromagnets, and how signalling from a damaged cell reduces chances of survival of neighbour cells, resulting in correlated cell states. At the root of the model is a classical Hamiltonian, similar to that of an Ising ferromagnet with long-range interactions. The formalism is developed in the framework of the Mean Field Theory. It is applied to modelling tissue response in a uniform radiation field. In this case the results are remarkably simple and at the same time nontrivial. They include cell survival curves, expressions for the tumour control probability and effects of fractionation. The model extends beyond of what is normally considered as bystander effects. It offers an insight into low-dose hypersensitivity and into mechanisms behind threshold doses for deterministic effects.

  7. Piglet birth weight and litter uniformity: effects of weaning-to-pregnancy interval and body condition changes in sows of different parities and crossbred lines. (United States)

    Wientjes, J G M; Soede, N M; Knol, E F; van den Brand, H; Kemp, B


    Piglet birth weight and litter uniformity were studied in sows of different parities and crossbred lines in relation to: 1) weaning-to-pregnancy interval (WPI) and 2) sow body condition changes (in BW and backfat thickness) during lactation and gestation in sows with a short WPI (≤7d). At the Institute for Pig Genetics (IPG) research farm, individual piglet birth weights and sow body condition (BW and backfat thickness at farrowing and weaning) were measured for 949 TOPIGS20 and 889 TOPIGS40 sows with >4 total born piglets, inseminated between 2003 and 2011. In all analyses, mean piglet birth weight and birth weight SD and CV were corrected for total number born. Total number born was greater in sows with a WPI of 8 to 21 d (+1.2 piglets; n = 72) and >21 d (+0.7 piglets; n = 182), compared with sows with a WPI ≤7 d (P piglet birth weight was not affected by WPI. Birth weight SD (-23 g) and CV (-1.7%) were lower in sows with a WPI >21 d, compared with sows with a WPI ≤7 d (P piglet birth weight. Only in TOPIGS20 sows, more BW loss during lactation was related with greater subsequent birth weight SD (β = 0.83 g/kg, P piglet/kg BW increase for parity 2 (P piglet/kg BW increase (P piglet birth weight. To conclude, this study shows that litter uniformity is compromised by severe sow body condition loss during lactation and improved in sows with a prolonged WPI. These effects are likely related with (insufficient) restoration of follicle development.

  8. Occurrence and Potential Biological Effects of Amphetamine on Stream Communities. (United States)

    Lee, Sylvia S; Paspalof, Alexis M; Snow, Daniel D; Richmond, Erinn K; Rosi-Marshall, Emma J; Kelly, John J


    The presence of pharmaceuticals, including illicit drugs in aquatic systems, is a topic of environmental significance because of their global occurrence and potential effects on aquatic ecosystems and human health, but few studies have examined the ecological effects of illicit drugs. We conducted a survey of several drug residues, including the potentially illicit drug amphetamine, at 6 stream sites along an urban to rural gradient in Baltimore, Maryland, U.S.A. We detected numerous drugs, including amphetamine (3 to 630 ng L(-1)), in all stream sites. We examined the fate and ecological effects of amphetamine on biofilm, seston, and aquatic insect communities in artificial streams exposed to an environmentally relevant concentration (1 μg L(-1)) of amphetamine. The amphetamine parent compound decreased in the artificial streams from less than 1 μg L(-1) on day 1 to 0.11 μg L(-1) on day 22. In artificial streams treated with amphetamine, there was up to 45% lower biofilm chlorophyll a per ash-free dry mass, 85% lower biofilm gross primary production, 24% greater seston ash-free dry mass, and 30% lower seston community respiration compared to control streams. Exposing streams to amphetamine also changed the composition of bacterial and diatom communities in biofilms at day 21 and increased cumulative dipteran emergence by 65% and 89% during the first and third weeks of the experiment, respectively. This study demonstrates that amphetamine and other biologically active drugs are present in urban streams and have the potential to affect both structure and function of stream communities.

  9. Examining the Effect of Multiple Writing Tasks on Year 10 Biology Students' Understandings of Cell and Molecular Biology Concepts (United States)

    Hand, Brian; Hohenshell, Liesl; Prain, Vaughan


    This paper reports on a study that examined the cumulative effects on students' learning of science, and perceptions of the role of writing in learning, when the students engaged in multiple writing tasks with planning strategy support. The study was conducted with Year 10 biology students who completed two consecutive units on Cells and Molecular…

  10. Uniform supersaturated design and its construction

    Institute of Scientific and Technical Information of China (English)

    方开泰; 葛根年; 刘民千


    Supersaturated designs are factorial designs in which the number of main effects is greater than the number of experimental runs. In this paper, a discrete discrepancy is proposed as a measure of uniformity for supersaturated designs, and a lower bound of this discrepancy is obtained asa benchmark of design uniformity. A construction method for uniform supersaturated designs via resolvable balanced incomplete block designs is also presented along with the investigation of properties of the resulting designs. The construction method shows a strong link between these two different kinds of designs.

  11. Determining environmental causes of biological effects: the need for a mechanistic physiological dimension in conservation biology


    Seebacher, Frank; Craig E. Franklin


    The emerging field of Conservation Physiology links environmental change and ecological success by the application of physiological theory, approaches and tools to elucidate and address conservation problems. Human activity has changed the natural environment to a point where the viability of many ecosystems is now under threat. There are already many descriptions of how changes in biological patterns are correlated with environmental changes. The next important step is to determine the causa...

  12. Relative Biological Effectiveness and Peripheral Damage of Antiproton Annihilation

    CERN Multimedia

    Kavanagh, J N; Kaiser, F; Tegami, S; Schettino, G; Kovacevic, S; Hajdukovic, D; Welsch, C P; Currell, F J; Toelli, H T; Doser, M; Holzscheiter, M; Herrmann, R; Timson, D J; Alsner, J; Landua, R; Knudsen, H; Comor, J; Moller, S P; Beyer, G


    The use of ions to deliver radiation to a body for therapeutic purposes has the potential to be significant improvement over the use of low linear energy transfer (LET) radiation because of the improved energy deposition profile and the enhanced biological effects of ions relative to photons. Proton therapy centers exist and are being used to treat patients. In addition, the initial use of heavy ions such as carbon is promising to the point that new treatment facilities are planned. Just as with protons or heavy ions, antiprotons can be used to deliver radiation to the body in a controlled way; however antiprotons will exhibit additional energy deposition due to annihilation of the antiprotons within the body. The slowing down of antiprotons in matter is similar to that of protons except at the very end of the range beyond the Bragg peak. Gray and Kalogeropoulos estimated the additional energy deposited by heavy nuclear fragments within a few millimeters of the annihilation vertex to be approximately 30 MeV (...

  13. Biological effectiveness of neutron irradiation on animals and man

    Energy Technology Data Exchange (ETDEWEB)

    Straume, T.


    Neutron experiments on a highly radiosensitive in vivo system - oocytes in mice - provide new insight into the nature of the radiosensitive targets of these important cells. With the radiobiological literature as background, neutron data from animals and humans are integrated, and the controversial question of radiation protection standards for neutrons is addressed. Oocyte killing in juvenile mice by 0.43-MeV, /sup 252/Cf-fission, and 15 MeV neutrons, compared with that by /sup 60/Co gamma rays, yields unusually low neutron RBEs (relative biological effectiveness). At 0.1 rad of 0.43-MeV neutrons the RBE is only 1.8, contrasting greatly with values of 100 or more reported at low-doses for other endpoints. In mice just prior to birth, however, when oocytes are less radiosensitive, the neutron RBE is much higher, similar to values for most other mammalian endpoints. This dramatic change in neutron RBE with mouse age (occurring within 2 to 3 days) can be explained as the result of a shift from a less radiosensitive target (presumably nuclear DNA) to a much more radiosensitive one (probably the oocyte plasma membrane). Using various approaches, a value for the neutron Quality Factor (Q, a radiation protection standard) is estimated as 17 (+-100%), much lower than 100 which has been suggested. With the large uncertainty, 17 is not markedly different from the value of 10 presently in general use.

  14. Stochastic Effects in Computational Biology of Space Radiation Cancer Risk (United States)

    Cucinotta, Francis A.; Pluth, Janis; Harper, Jane; O'Neill, Peter


    Estimating risk from space radiation poses important questions on the radiobiology of protons and heavy ions. We are considering systems biology models to study radiation induced repair foci (RIRF) at low doses, in which less than one-track on average transverses the cell, and the subsequent DNA damage processing and signal transduction events. Computational approaches for describing protein regulatory networks coupled to DNA and oxidative damage sites include systems of differential equations, stochastic equations, and Monte-Carlo simulations. We review recent developments in the mathematical description of protein regulatory networks and possible approaches to radiation effects simulation. These include robustness, which states that regulatory networks maintain their functions against external and internal perturbations due to compensating properties of redundancy and molecular feedback controls, and modularity, which leads to general theorems for considering molecules that interact through a regulatory mechanism without exchange of matter leading to a block diagonal reduction of the connecting pathways. Identifying rate-limiting steps, robustness, and modularity in pathways perturbed by radiation damage are shown to be valid techniques for reducing large molecular systems to realistic computer simulations. Other techniques studied are the use of steady-state analysis, and the introduction of composite molecules or rate-constants to represent small collections of reactants. Applications of these techniques to describe spatial and temporal distributions of RIRF and cell populations following low dose irradiation are described.

  15. Effects of Simulated Rare Earth Recycling Wastewaters on Biological Nitrification. (United States)

    Fujita, Yoshiko; Barnes, Joni; Eslamimanesh, Ali; Lencka, Malgorzata M; Anderko, Andrzej; Riman, Richard E; Navrotsky, Alexandra


    Increasing rare earth element (REE) supplies by recycling and expanded ore processing will result in generation of new wastewaters. In some cases, disposal to a sewage treatment plant may be favored, but plant performance must be maintained. To assess the potential effects of such wastewaters on biological treatment, model nitrifying organisms Nitrosomonas europaea and Nitrobacter winogradskyi were exposed to simulated wastewaters containing varying levels of yttrium or europium (10, 50, and 100 ppm), and the extractant tributyl phosphate (TBP, at 0.1 g/L). Y and Eu additions at 50 and 100 ppm inhibited N. europaea, even when virtually all of the REE was insoluble. Provision of TBP with Eu increased N. europaea inhibition, although TBP alone did not substantially alter activity. For N. winogradskyi cultures, Eu or Y additions at all tested levels induced significant inhibition, and nitrification shut down completely with TBP addition. REE solubility was calculated using the previously developed MSE (Mixed-Solvent Electrolyte) thermodynamic model. The model calculations reveal a strong pH dependence of solubility, typically controlled by the precipitation of REE hydroxides but also likely affected by the formation of unknown phosphate phases, which determined aqueous concentrations experienced by the microorganisms.

  16. Chemical and biological oxidative effects of carbon black nanoparticles. (United States)

    Koike, Eiko; Kobayashi, Takahiro


    Several studies show that ultrafine particles have a larger surface area than coarse particles, thus causing a greater inflammatory response. In this study, we investigated chemical and biological oxidative effects of nanoparticles in vitro. Carbon black (CB) nanoparticles with mean aerodynamic diameters of 14, 56, and 95nm were examined. The innate oxidative capacity of the CB nanoparticles was measured by consumption of dithiothreitol (DTT) in cell-free system. The expression of heme oxygenase-1 (HO-1) in rat alveolar type II epithelial cell line (SV40T2) and alveolar macrophages (AM) exposed to CB nanoparticles was measured by ELISA. DTT consumption of 14nm CB was higher than that of other CB nanoparticles having the same particle weight. However, DTT consumption was directly proportional to the particle surface area. HO-1 protein in SV40T2 cells was significantly increased by the 14nm and 56nm CB, however, 95nm CB did not affect. HO-1 protein in AM was significantly increased by the 14, 56, and 95nm CB. The increase in HO-1 expression was diminished by N-acetyl-l-cysteine (NAC) treatment of each CB nanoparticles before exposure although the difference between the effects of NAC-treated and untreated 14nm CB did not achieve significant. In conclusion, CB nanoparticles have innate oxidative capacity that may be dependent on the surface area. CB nanoparticles can induce oxidative stress in alveolar epithelial cells and AM that is more prominent with smaller particles. The oxidative stress may, at least partially, be mediated by surface function of particles.

  17. Tea polyphenols, their biological effects and potential molecular targets. (United States)

    Chen, D; Milacic, V; Chen, M S; Wan, S B; Lam, W H; Huo, C; Landis-Piwowar, K R; Cui, Q C; Wali, A; Chan, T H; Dou, Q P


    Tea is the most popular beverage in the world, second only to water. Tea contains an infusion of the leaves from the Camellia sinensis plant rich in polyphenolic compounds known as catechins, the most abundant of which is (-)-EGCG. Although tea has been consumed for centuries, it has only recently been studied extensively as a health-promoting beverage that may act to prevent a number of chronic diseases and cancers. The results of several investigations indicate that green tea consumption may be of modest benefit in reducing the plasma concentration of cholesterol and preventing atherosclerosis. Additionally, the cancer-preventive effects of green tea are widely supported by results from epidemiological, cell culture, animal and clinical studies. In vitro cell culture studies show that tea polyphenols potently induce apoptotic cell death and cell cycle arrest in tumor cells but not in their normal cell counterparts. Green tea polyphenols were shown to affect several biological pathways, including growth factor-mediated pathway, the mitogen-activated protein (MAP) kinase-dependent pathway, and ubiquitin/proteasome degradation pathways. Various animal studies have revealed that treatment with green tea inhibits tumor incidence and multiplicity in different organ sites such as skin, lung, liver, stomach, mammary gland and colon. Recently, phase I and II clinical trials have been conducted to explore the anticancer effects of green tea in humans. A major challenge of cancer prevention is to integrate new molecular findings into clinical practice. Therefore, identification of more molecular targets and biomarkers for tea polyphenols is essential for improving the design of green tea trials and will greatly assist in a better understanding of the mechanisms underlying its anti-cancer activity.

  18. Evidence of market-driven size-selective fishing and the mediating effects of biological and institutional factors (United States)

    Reddy, Sheila M. W.; Wentz, Allison; Aburto-Oropeza, Octavio; Maxey, Martin; Nagavarapu, Sriniketh; Leslie, Heather M.


    Market demand is often ignored or assumed to lead uniformly to the decline of resources. Yet little is known about how market demand influences natural resources in particular contexts, or the mediating effects of biological or institutional factors. Here, we investigate this problem by examining the Pacific red snapper (Lutjanus peru) fishery around La Paz, Mexico, where medium or “plate-sized” fish are sold to restaurants at a premium price. If higher demand for plate-sized fish increases the relative abundance of the smallest (recruit size class) and largest (most fecund) fish, this may be a market mechanism to increase stocks and fishermen’s revenues. We tested this hypothesis by estimating the effect of prices on the distribution of catch across size classes using daily records of prices and catch. We linked predictions from this economic choice model to a staged-based model of the fishery to estimate the effects on the stock and revenues from harvest. We found that the supply of plate-sized fish increased by 6%, while the supply of large fish decreased by 4% as a result of a 13% price premium for plate-sized fish. This market-driven size selection increased revenues (14%) but decreased total fish biomass (−3%). However, when market-driven size selection was combined with limited institutional constraints, both fish biomass (28%) and fishermen’s revenue (22%) increased. These results show that the direction and magnitude of the effects of market demand on biological populations and human behavior can depend on both biological attributes and institutional constraints. Fisheries management may capitalize on these conditional effects by implementing size-based regulations when economic and institutional incentives will enhance compliance, as in the case we describe here, or by creating compliance enhancing conditions for existing regulations. PMID:23865225

  19. Should School Nurses Wear Uniforms? (United States)

    Journal of School Health, 2001


    This 1958 paper questions whether school nurses should wear uniforms (specifically, white uniforms). It concludes that white uniforms are often associated with the treatment of ill people, and since many people have a fear reaction to them, they are not necessary and are even undesirable. Since school nurses are school staff members, they should…

  20. Uniform quantized electron gas (United States)

    Høye, Johan S.; Lomba, Enrique


    In this work we study the correlation energy of the quantized electron gas of uniform density at temperature T  =  0. To do so we utilize methods from classical statistical mechanics. The basis for this is the Feynman path integral for the partition function of quantized systems. With this representation the quantum mechanical problem can be interpreted as, and is equivalent to, a classical polymer problem in four dimensions where the fourth dimension is imaginary time. Thus methods, results, and properties obtained in the statistical mechanics of classical fluids can be utilized. From this viewpoint we recover the well known RPA (random phase approximation). Then to improve it we modify the RPA by requiring the corresponding correlation function to be such that electrons with equal spins can not be on the same position. Numerical evaluations are compared with well known results of a standard parameterization of Monte Carlo correlation energies.

  1. Uniformly rotating neutron stars

    CERN Document Server

    Boshkayev, Kuantay


    In this chapter we review the recent results on the equilibrium configurations of static and uniformly rotating neutron stars within the Hartle formalism. We start from the Einstein-Maxwell-Thomas-Fermi equations formulated and extended by Belvedere et al. (2012, 2014). We demonstrate how to conduct numerical integration of these equations for different central densities ${\\it \\rho}_c$ and angular velocities $\\Omega$ and compute the static $M^{stat}$ and rotating $M^{rot}$ masses, polar $R_p$ and equatorial $R_{\\rm eq}$ radii, eccentricity $\\epsilon$, moment of inertia $I$, angular momentum $J$, as well as the quadrupole moment $Q$ of the rotating configurations. In order to fulfill the stability criteria of rotating neutron stars we take into considerations the Keplerian mass-shedding limit and the axisymmetric secular instability. Furthermore, we construct the novel mass-radius relations, calculate the maximum mass and minimum rotation periods (maximum frequencies) of neutron stars. Eventually, we compare a...

  2. Re-examination of the Pt Particle Size Effect on the Oxygen Reduction Reaction for Ultrathin Uniform Pt/C Catalyst Layers without Influence from Nafion

    Energy Technology Data Exchange (ETDEWEB)

    Shinozaki, Kazuma; Morimoto, Yu; Pivovar, Bryan S.; Kocha, Shyam S.


    The platinum 'particle size effect' on the oxygen reduction reaction (ORR) has been re-evaluated using commercial Pt/C catalysts (2-10 nm Pt particle) and polycrystalline Pt (poly-Pt) in 0.1 M HClO4 with a rotating disk electrode method. Nafion-free catalyst layers were employed to obtain specific activities (SA) that were not perturbed (suppressed) by sulfonate anion adsorption/blocking. By using ultrathin uniform catalyst layers, O2 diffusion limitation was minimized as confirmed from the high SAs of our supported catalysts that were comparable to unsupported sputtered Pt having controlled sizes. The specific activity (SA) steeply increased for the particle sizes in the range -2-10 nm (0.8-1.8 mA/cm2Pt at 0.9 V vs. RHE) and plateaued over -10 nm to 2.7 mA/cm2Pt for bulk poly-Pt. On the basis of the activity trend for the range of particle sizes studied, it appears that the effect of carbon support on activity is negligible. The experimental results and the concomitant profile of SA vs. particle size was found to be in an agreement to a truncated octahedral particle model that assumes active terrace sites.

  3. Soret and Dufour Effects on Unsteady MHD Heat and Mass Transfer from a Permeable Stretching Sheet with Thermophoresis and Non-Uniform Heat Generation/Absorption

    Directory of Open Access Journals (Sweden)

    P. Sudarsana Reddy


    Full Text Available This paper is focused on the study of heat and mass transfer characteristics of an unsteady MHD boundary layer flow through porous medium over a stretching sheet in the presence of thermo-diffusion and diffusion-thermo effects with thermophoresis, thermal radiation and non-uniform heat source/sink. The transformed conservation equations are solved numerically subject to the boundary conditions using an optimized, extensively validated, variational finite element analysis. The numerical code is validated with previous studies on special cases of the problem. The influence of important non-dimensional parameters, namely suction parameter (f_w, magnetic parameter (M, unsteadiness parameter (α, Soret parameter (Sr, Dufour parameter (Du thermophoretic parameter (τ, space dependent (A1 and temperature dependent parameters (B1 and radiation parameter(An on the velocity, temperature and concentration fields as well as the skin-friction coefficient, Nusselt number and Sherwood number are examined in detail and the results are shown graphically and in tabular form to know the physical importance of the problem. It is found that the imposition of wall fluid suction (f_w>0 in the flow problem has the effect of depreciating the velocity, temperature and concentration boundary layer thicknesses at every finite value of η. This deceleration in momentum, thermal and concentration profiles is because of the fact that suction is taken away the warm fluid from the surface of the stretching sheet.

  4. The Effects of Ultrasound on Biological Systems: Site (United States)

    El-Karmi, Anan M.

    vs. 18 minutes). This demonstrates that the biological effects of ultrasound are influenced by Ca^ {2+}. The larger increases in G _{rm t} and the time constants confirm other studies addressing the role of Ca ^{2+} in potentiating lipid peroxidation by free radicals, and the role of calcium ions in the formation of tight junctions.

  5. Penetration and propagation into biological matter and biological effects of high-power ultra-wideband pulses: a review. (United States)

    Schunck, Thérèse; Bieth, François; Pinguet, Sylvain; Delmote, Philippe


    Systems emitting ultra-wideband high power microwave (HP/UWB) pulses are developed for military and civilian applications. HP/UWB pulses typically have durations on the order of nanoseconds, rise times of picoseconds and amplitudes around 100 kV m(-1). This article reviews current research on biological effects from HP/UWB exposure. The different references were classified according to endpoints (cardiovascular system, central nervous system, behavior, genotoxicity, teratology …). The article also reviews the aspects of mechanisms of interactions and tissue damage as well as the numerical work that has been done for studying HP/UWB pulse propagation and pulse energy deposition inside biological tissues. The mechanisms proposed are the molecular conformation change, the modification of chemical reaction rates, membrane excitation and breakdown and direct electrical forces on cells or cell constituents, and the energy deposition. As regards the penetration of biological matter and the deposited energy, mainly computations were published. They have shown that the EM field inside the biological matter is strongly modified compared to the incident EM field and that the energy absorption for HP/UWB pulses occurs in the same way as for continuous waves. However, the energy carried by a HP/UWB pulse is very low and the deposited energy is low. The number of published studies dealing with the biological effects is small and only a few pointed out slight effects. It should be further noted that the animal populations used in the studies were not always large, the statistical analyses not always relevant and the teams involved in this research rather limited in number.

  6. Countermeasures for Space Radiation Induced Malignancies and Acute Biological Effects (United States)

    Kennedy, Ann

    The hypothesis being evaluated in this research program is that control of radiation induced oxidative stress will reduce the risk of radiation induced adverse biological effects occurring as a result of exposure to the types of radiation encountered during space travel. As part of this grant work, we have evaluated the protective effects of several antioxidants and dietary supplements and observed that a mixture of antioxidants (AOX), containing L-selenomethionine, N-acetyl cysteine (NAC), ascorbic acid, vitamin E succinate, and alpha-lipoic acid, is highly effective at reducing space radiation induced oxidative stress in both in vivo and in vitro systems, space radiation induced cytotoxicity and malignant transformation in vitro [1-7]. In studies designed to determine whether the AOX formulation could affect radiation induced mortality [8], it was observed that the AOX dietary supplement increased the 30-day survival of ICR male mice following exposure to a potentially lethal dose (8 Gy) of X-rays when given prior to or after animal irradiation. Pretreatment of animals with antioxidants resulted in significantly higher total white blood cell and neutrophil counts in peripheral blood at 4 and 24 hours following exposure to doses of 1 Gy and 8 Gy. Antioxidant treatment also resulted in increased bone marrow cell counts following irradiation, and prevented peripheral lymphopenia following 1 Gy irradiation. Supplementation with antioxidants in irradiated animals resulted in several gene expression changes: the antioxidant treatment was associated with increased Bcl-2, and decreased Bax, caspase-9 and TGF-β1 mRNA expression in the bone marrow following irradiation. These results suggest that modulation of apoptosis may be mechanistically involved in hematopoietic system radioprotection by antioxidants. Maintenance of the antioxidant diet was associated with improved recovery of the bone marrow following sub-lethal or potentially lethal irradiation. Taken together

  7. Essential Oils from Thyme (Thymus vulgaris): Chemical Composition and Biological Effects in Mouse Model. (United States)

    Vetvicka, Vaclav; Vetvickova, Jana


    Thymus species are popular spices and contain volatile oils as main chemical constituents. Recently, plant-derived essential oils are gaining significant attention due to their significant biological activities. Seven different thymus-derived essential oils were compared in our study. First, we focused on their chemical composition, which was followed up by testing their effects on phagocytosis, cytokine production, chemotaxis, edema inhibition, and liver protection. We found limited biological activities among tested oils, with no correlation between composition and biological effects. Similarly, no oils were effective in every reaction. Based on our data, the tested biological use of these essential oils is questionable.

  8. Effect of Process-Oriented Guided-Inquiry Learning on Non-majors Biology Students' Understanding of Biological Classification (United States)

    Wozniak, Breann M.

    The purpose of this study was to examine the effect of process-oriented guided-inquiry learning (POGIL) on non-majors college biology students' understanding of biological classification. This study addressed an area of science instruction, POGIL in the non-majors college biology laboratory, which has yet to be qualitatively and quantitatively researched. A concurrent triangulation mixed methods approach was used. Students' understanding of biological classification was measured in two areas: scores on pre and posttests (consisting of 11 multiple choice questions), and conceptions of classification as elicited in pre and post interviews and instructor reflections. Participants were Minnesota State University, Mankato students enrolled in BIOL 100 Summer Session. One section was taught with the traditional curriculum (n = 6) and the other section in the POGIL curriculum (n = 10) developed by the researcher. Three students from each section were selected to take part in pre and post interviews. There were no significant differences within each teaching method (p vs. M = 7.330 +/- .330; z =-1.729, p = .084) and the traditional group may have scored higher on the pretest than the posttest (M = 8.333 +/- .333 vs M = 7.333 +/- .333; z = -1.650 , p = .099). Two themes emerged after the interviews and instructor reflections: 1) After instruction students had a more extensive understanding of classification in three areas: vocabulary terms, physical characteristics, and types of evidence used to classify. Both groups extended their understanding, but only POGIL students could explain how molecular evidence is used in classification. 2) The challenges preventing students from understanding classification were: familiar animal categories and aquatic habitats, unfamiliar organisms, combining and subdividing initial groupings, and the hierarchical nature of classification. The POGIL students were the only group to surpass these challenges after the teaching intervention. This

  9. Radioprotection, biological effects of the radiations and security in the handling of radioactive material

    CERN Document Server

    Teran, M


    The development of the philosophy of the radioprotection is dependent on the understanding of the effects of the radiation in the man. Behind the fact that the radiation is able to produce biological damages there are certain factors with regard to the biological effects of the radiations that determine the boarding of the radioprotection topics.

  10. Effect of Uniform Dispersion of Single-Wall Carbon Nanotubes on the Thermoelectric Properties of BiSbTe-Based Nanocomposites (United States)

    Ahmad, Kaleem; Wan, Chunlei; Al-Eshaikh, Mohammad A.


    Thermoelectric properties of BiSbTe-based bulk nanocomposites by incorporation of single-wall carbon nanotubes (SWCNTs) in different (0.0, 0.5, 1.0 and 1.5) vol.% were investigated from 300 K to 500 K. SWCNTs were uniformly dispersed in BiSbTe via a combination of ultra-sonication, magnetic stirring and mild ball milling. Fine BiSbTe powder was formed by crushing and ball milling the lumps in an inert environment. The composites demonstrate grain boundary structures exhibiting a three-dimensional network of one-dimensional flexible SWCNTs in BiSbTe bulks. The homogenous distribution of SWCNTs in BiSbTe drastically changes the transport properties of the composites. At 0.5 vol.% of SWCNTs, the effective thermal conductivity decreases suggesting the increased phonon scattering. Meanwhile, at 1.0 vol.% and 1.5 vol.%, the conductivities of the composites somehow increases attributed to homogenous distribution of SWCNTs in the BiSbTe matrix. The increased electrical resistivity with the addition of SWCNTs implies the enhanced scattering of carriers at the grain boundaries and SWCNTs/BiSbTe interfaces. The dimensionless figure of merit somewhat decreases with the addition of 0.5 vol.% SWCNTs. The results suggest that the figure of merit can be improved by optimizing the SWCNT composition below 0.5 vol.% by adequately tailoring the thermoelectric transport.

  11. Synergetic Effect of Yolk-Shell Structure and Uniform Mixing of SnS-MoS₂ Nanocrystals for Improved Na-Ion Storage Capabilities. (United States)

    Choi, Seung Ho; Kang, Yun Chan


    Mixed metal sulfide composite microspheres with a yolk-shell structure for sodium-ion batteries are studied. Tin-molybdenum oxide yolk-shell microspheres prepared by a one-pot spray pyrolysis process transform into yolk-shell SnS-MoS2 composite microspheres. The discharge capacities of the yolk-shell and dense-structured SnS-MoS2 composite microspheres for the 100th cycle are 396 and 207 mA h g(-1), and their capacity retentions measured from the second cycle are 89 and 47%, respectively. The yolk-shell SnS-MoS2 composite microspheres with high structural stability during repeated sodium insertion and desertion processes have low charge-transfer resistance even after long-term cycling. The synergetic effect of the yolk-shell structure and uniform mixing of the SnS and MoS2 nanocrystals result in the excellent sodium-ion storage properties of the yolk-shell SnS-MoS2 composite microspheres by improving their structural stability during cycling.

  12. Effects of Soret and Non-Uniform Heat Source on MHD Non-Darcian Convective Flow over a Stretching Sheet in a Dissipative Micropolar Fluid with Radiation

    Directory of Open Access Journals (Sweden)

    Fazle Mabood


    Full Text Available This study presents a numerical analysis on the effects of Soret, variable thermal conductivity, viscous-Ohmic dissipation, non-uniform heat sources, on steady two-dimensional hydromagnetic mixed convective heat and mass transfer flow of a micropolar fluid over a stretching sheet embedded in a non-Darcian porous medium with thermal radiation and chemical reaction. The governing differential equations are transformed into a set of non-linear coupled ordinary differential equations which are then solved numerically by using the fifth-order Runge-Kutta-Fehlberg method with shooting technique. Numerical solutions are obtained for the velocity, angular velocity, temperature and concentration profiles for various parametric values, and then results are presented graphically as well as skin-friction coefficient, and also local Nusselt number and local Sherwood number for different physical parameters are shown graphically and in tabular form. A critical analysis with earlier published papers was done, and the results were found to be in accordance with each other.

  13. A study of two subgrid-scale models and their effects on wake breakdown behind a wind turbine in uniform inflow (United States)

    Martinez, Luis; Meneveau, Charles


    Large Eddy Simulations (LES) of the flow past a single wind turbine with uniform inflow have been performed. A goal of the simulations is to compare two turbulence subgrid-scale models and their effects in predicting the initial breakdown, transition and evolution of the wake behind the turbine. Prior works have often observed negligible sensitivities to subgrid-scale models. The flow is modeled using an in-house LES with pseudo-spectral discretization in horizontal planes and centered finite differencing in the vertical direction. Turbines are represented using the actuator line model. We compare the standard constant-coefficient Smagorinsky subgrid-scale model with the Lagrangian Scale Dependent Dynamic model (LSDM). The LSDM model predicts faster transition to turbulence in the wake, whereas the standard Smagorinsky model predicts significantly delayed transition. The specified Smagorinsky coefficient is larger than the dynamic one on average, increasing diffusion thus delaying transition. A second goal is to compare the resulting near-blade properties such as local aerodynamic forces from the LES with Blade Element Momentum Theory. Results will also be compared with those of the SOWFA package, the wind energy CFD framework from NREL. This work is supported by NSF (IGERT and IIA-1243482) and computations use XSEDE resources, and has benefitted from interactions with Dr. M. Churchfield of NREL.

  14. Computational modeling of geometry effects on the IDL surface concentration in the presence of non-uniform magnetic field - links to atherosclerosis (United States)

    Aminfar, H.; Mohammadpourfard, M.; Khajeh, K.


    Effect of geometry on the atherosclerosis is a significant issue, so the 3D s-shape and 2D axisymmetric stenosis tube as a blood vessel have been analyzed in this work. This paper has focused on the most important parameters in the LSC uptake, inlet Re number and infiltration velocity in the presence of non-uniform magnetic field. The magnetic field is arising from the thin wire with electric current placed vertically to the arterial blood vessel. According to the results of this study, applying magnetic field can be a treatment for atherosclerosis by reducing LSC along the vessel wall. It is observed that, application of magnetic field leads to production of a vortex in the flow, high strain rate, increment of WSS, and also reduction in LSC. For solving the mass transport equation, Lumen-wall model has been used. Blood flow has been considered laminar and incompressible containing Ferro fluid (blood and 4 vol% Fe3O4) under steady state conditions. Numerical solution of governing equations was obtained by using the single-phase model and control volume technique for flow field.

  15. Radon exposure of the skin: I. Biological effects

    Energy Technology Data Exchange (ETDEWEB)

    Charles, M W [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham B15 2TT (United Kingdom)


    Radon progeny can plate out on skin and give rise to exposure of the superficial epidermis from alpha emitters Po-218 (7.7 MeV, range {approx}66 {mu}m) and Po-214 (6 MeV, range {approx}44 {mu}m). Dose rates from beta/gamma emitters Pb-214 and Bi-214 are low and only predominate at depths in excess of the alpha range. This paper reviews the evidence for a causal link between exposure from radon and its progeny, and deterministic and stochastic biological effects in human skin. Radiation induced skin effects such as ulceration and dermal atrophy, which require irradiation of the dermis, are ruled out for alpha irradiation from radon progeny because the target cells are considerably deeper than the range of alpha particles. They have not been observed in man or animals. Effects such as erythema and acute epidermal necrosis have been observed in a few cases of very high dose alpha particle exposures in man and after acute high dose exposure in animals from low energy beta radiations with similar depth doses to radon progeny. The required skin surface absorbed doses are in excess of 100 Gy. Such effects would require extremely high levels of radon progeny. They would involve quite exceptional circumstances, way outside the normal range of radon exposures in man. There is no definitive identification of the target cells for skin cancer induction in animals or man. The stem cells in the basal layer which maintain the epidermis are the most plausible contenders for target cells. The majority of these cells are near the end of the range of radon progeny alpha particles, even on the thinnest body sites. The nominal depth of these cells, as recommended by the International Commission on Radiological Protection (ICRP), is 70 {mu}m. There is evidence however that some irradiation of the hair follicles and/or the deeper dermis, as well as the inter-follicular epidermis, is also necessary for skin cancer induction. Alpha irradiation of rodent skin that is restricted to the

  16. Controlling the Biological Effects of Spermine Using a Synthetic Receptor

    NARCIS (Netherlands)

    Vial, Laurent; Ludlow, R. Frederick; Leclaire, Julien; Pérez-Fernández, Ruth; Otto, Sijbren


    Polyamines play an important role in biology, yet their exact function in many processes is poorly understood. Artificial host molecules capable of sequestering polyamines could be useful tools for studying their cellular function. However, designing synthetic receptors with affinities sufficient to

  17. Assessment indices for uniform and non-uniform thermal environments

    Institute of Scientific and Technical Information of China (English)


    Different assessment indices for thermal environments were compared and selected for proper assessment of indoor thermal environments.30 subjects reported their overall thermal sensation,thermal comfort,and thermal acceptability in uniform and non-uniform conditions.The results show that these three assessment indices provide equivalent evaluations in uniform environments.However,overall thermal sensation differs from the other two indices and cannot be used as a proper index for the evaluation of non-uniform environments.The relationship between the percentage and the mean vote for each index is established.

  18. Effects of the Reynolds number on two-dimensional dielectrophoretic motions of a pair of particles under a uniform electric field

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Sang Mo; Mannoor, Madhusoodanan [Dong-A University, Busan (Korea, Republic of); Maniyeri, Ranjith Maniyeri [National Institute of Technology Karnataka, Mangalore (India)


    This paper presents two-dimensional direct numerical simulations to explore the effect of the Reynolds number on the Dielectrophoretic (DEP) motion of a pair of freely suspended particles in an unbounded viscous fluid under an external uniform electric field. Accordingly, the electric potential is obtained by solving the Maxwell'00s equation with a great sudden change in the electric conductivity at the particle-fluid interface and then the Maxwell stress tensor is integrated to determine the DEP force exerted on each particle. The fluid flow and particle movement, on the other hand, are predicted by solving the continuity and Navier-Stokes equations together with the kinetic equations. Numerical simulations are carried out using a finite volume approach, composed of a sharp interface method for the electric potential and a direct-forcing immersed-boundary method for the fluid flow. Through the simulations, it is found that both particles with the same sign of the conductivity revolve and eventually align themselves in a line with the electric field. With different signs, to the contrary, they revolve in the reverse way and eventually become lined up at a right angle with the electric field. The DEP motion also depends significantly on the Reynolds number defined based on the external electric field for all the combinations of the conductivity signs. When the Reynolds number is approximately below Re{sub cr} ≈ 0.1, the DEP motion becomes independent of the Reynolds number and thus can be exactly predicted by the no-inertia solver that neglects all the inertial and convective effects. With increasing Reynolds number above the critical number, on the other hand, the particles trace larger trajectories and thus take longer time during their revolution to the eventual in-line alignment.

  19. Revision of single atom local density and capture number varying with coverage in uniform depletion approximation and its effect on coalescence and number of stable clusters

    Institute of Scientific and Technical Information of China (English)

    Shao Qing-Yi; Zhang Juan


    In vapour deposition,single atoms(adatoms)on the substrate surface are the main source of growth.The change in its density plays a decisive role in the growth of thin films and quantum size islands.In the nucleation and cluster coalescence stages of vapour deposition,the growth of stable clusters occurs on the substrate surface covered by stable clusters.Nucleation occurs in the non-covered part,while the total area covered by stable clusters on the substrate surface will gradually increase.Carefully taking into account the coverage effect,a revised single atom density rate equation is given for the famous and widely used thin-film rate equation theory,but the work of solving the revised equation has not been done.In this paper,we solve the equation and obtain the single-atom density and capture number by using a uniform depletion approximation.We determine that the single atom density is much lower than that evaluated from the single atom density rate equation in the traditional rate equation theory when the stable cluster coverage fraction is large,and it goes down very fast with an increase in the coverage fraction.The revised equation gives a higher value for the 'average' capture number than the present equation. It also increases with increasing coverage.That makes the preparation of single crystalline thin film materials difficult and the size control of quantum size islands complicated.We also discuss the effect of the revision on coalescence and the number of stable clusters in vapour deposition.


    Institute of Scientific and Technical Information of China (English)

    佟景伟; P.Priolo; 等


    为分析引起复合材料多层板自由边沿效应与端部效应的物理因素,分别研究了弹性模量、泊松比和上下两层材料主轴方向夹角对自由边沿效应的影响,给出了相应的三维有限元层间应力解及其三维分布图.结果表明,弹性模量和上下两层材料主轴方向夹角使层合板上下两层变形不一致,引起多层板自由边沿效应与端部效应,其泊松比是直接影响因素.%To study the edge effects of fiber-enforced composite laminatesunder uniform axial strain,influences of elastic modulus,Poisson ratio and the angle between the material axes of the two adjacent layers on the stress distribution are analyzed.The three-dimensional finite element interlaminar stress solutions of cross-ply and angle-ply laminates and their three dimensional distrrbution-plots are presented.The results demonstrate that the elastic modulus and angle of the adjacent material axes are direct elements of edge effects of the composite laminates.Furthermore,Poisson ratio is the elementary cause of these phenomena.

  1. Biological Effects of Listeriolysin O: Implications for Vaccination

    Directory of Open Access Journals (Sweden)

    K. G. Hernández-Flores


    Full Text Available Listeriolysin O (LLO is a thiol-activated cholesterol-dependent pore-forming toxin and the major virulence factor of Listeria monocytogenes (LM. Extensive research in recent years has revealed that LLO exerts a wide array of biological activities, during the infection by LM or by itself as recombinant antigen. The spectrum of biological activities induced by LLO includes cytotoxicity, apoptosis induction, endoplasmic reticulum stress response, modulation of gene expression, intracellular calcium oscillations, and proinflammatory activity. In addition, LLO is a highly immunogenic toxin and the major target for innate and adaptive immune responses in different animal models and humans. Recently, the crystal structure of LLO has been published in detail. Here, we review the structure-function relationship for this fascinating microbial molecule, highlighting the potential uses of LLO in the fields of biomedicine and biotechnology, particularly in vaccination.

  2. Uniform magnetic excitations in nanoparticles

    DEFF Research Database (Denmark)

    Mørup, Steen; Hansen, Britt Rosendahl


    We have used a spin-wave model to calculate the temperature dependence of the (sublattice) magnetization of magnetic nanoparticles. The uniform precession mode, corresponding to a spin wave with wave vector q=0, is predominant in nanoparticles and gives rise to an approximately linear temperature...... dependence of the (sublattice) magnetization well below the superparamagnetic blocking temperature for both ferro-, ferri-, and antiferromagnetic particles. This is in accordance with the results of a classical model for collective magnetic excitations in nanoparticles. In nanoparticles of antiferromagnetic...... materials, quantum effects give rise to a small deviation from the linear temperature dependence of the (sublattice) magnetization at very low temperatures. The complex nature of the excited precession states of nanoparticles of antiferromagnetic materials, with deviations from antiparallel orientation...

  3. Resurrecting the body: Has portmodernism had any effect on biology? (United States)

    Gilbert, S F


    While postmodernism has had very little influence in biology (for reasons discussed in the paper), it can provide a framework for discussing the context in which biology is done. Here, four biological views of the body/self are contrasted: the neural, immunological, genetic, and phenotypic bodies. Each physical view of the body extrapolates into a different model of the body politic, and each posits a different relationship between bodies of knowledge. The neural view of the body models a body politic wherein society is defined by its culture and laws. The genetic view privileges views of polities based on ethnicity and race. The immune body extrapolates into polities that can defend themselves against other such polities. The phenotypic view of the body politic stands in opposition to these three major perspectives and integrates them without giving any predominance. The view of science as a "neural" body of knowledge contends that science is aperspectival and objective. The perspective of the "immune" body is that science exists to defend the interests of its creataors. The genetic view of science is that science is the basis of all culture. The extrapolation of the phenotypic body to science insists upon the utilitarian rationale for scientific interprises. In all instances, the genetic view of the body/body politic/body of science is presently in ascendance.

  4. Effect of ceramic membrane channel geometry and uniform transmembrane pressure on limiting flux and serum protein removal during skim milk microfiltration. (United States)

    Adams, Michael C; Hurt, Emily E; Barbano, David M


    Our objectives were to determine the effects of a ceramic microfiltration (MF) membrane's retentate flow channel geometry (round or diamond-shaped) and uniform transmembrane pressure (UTP) on limiting flux (LF) and serum protein (SP) removal during skim milk MF at a temperature of 50°C, a retentate protein concentration of 8.5%, and an average cross-flow velocity of 7 m·s(-1). Performance of membranes with round and diamond flow channels was compared in UTP mode. Performance of the membrane with round flow channels was compared with and without UTP. Using UTP with round flow channel MF membranes increased the LF by 5% when compared with not using UTP, but SP removal was not affected by the use of UTP. Using membranes with round channels instead of diamond-shaped channels in UTP mode increased the LF by 24%. This increase was associated with a 25% increase in Reynolds number and can be explained by lower shear at the vertices of the diamond-shaped channel's surface. The SP removal factor of the diamond channel system was higher than the SP removal factor of the round channel system below the LF. However, the diamond channel system passed more casein into the MF permeate than the round channel system. Because only one batch of each membrane was tested in our study, it was not possible to determine if the differences in protein rejection between channel geometries were due to the membrane design or random manufacturing variation. Despite the lower LF of the diamond channel system, the 47% increase in membrane module surface area of the diamond channel system produced a modular permeate removal rate that was at least 19% higher than the round channel system. Consequently, using diamond channel membranes instead of round channel membranes could reduce some of the costs associated with ceramic MF of skim milk if fewer membrane modules could be used to attain the required membrane area.

  5. Non-uniform tube representation of proteins

    DEFF Research Database (Denmark)

    Hansen, Mikael Sonne

    might not correctly capture volume exclusion - of crucial importance when trying to understand a proteins $3$d-structure. We propose a new reduced model treating the protein as a non-uniform tube with a radius reflecting the positions of atoms. The tube representation is well suited considering X......Treating the full protein structure is often neither computationally nor physically possible. Instead one is forced to consider various reduced models capturing the properties of interest. Previous work have used tubular neighborhoods of the C-alpha backbone. However, assigning a unique radius......-ray crystallographic resolution ~ 3Å while a varying radius accounts for the different sizes of side chains. Such a non-uniform tube better capture the protein geometry and has numerous applications in structural/computational biology from the classification of protein structures to sequence-structure prediction....

  6. Non-Uniform Tube Representation of Proteins

    DEFF Research Database (Denmark)

    Hansen, Mikael Sonne

    might not correctly capture volume exclusion - of crucial importance when trying to understand a protein's 3d-structure. We propose a new reduced model treating the protein as a non-uniform tube with a radius reflecting the positions of atoms. The tube representation is well suited considering X......Treating the full protein structure is often neither computationally nor physically possible. Instead one is forced to consider various reduced models capturing the properties of interest. Previous work have used tubular neighborhoods of the C-alpha backbone. However, assigning a unique radius......-ray crystallographic resolution ~ 3Å while a varying radius accounts for the different sizes of side chains. Such a non-uniform tube better captures the protein geometry and has numerous applications in structural/computational biology from the classification of protein structures to sequence-structure prediction....

  7. Adverse effects of biologics: a network meta-analysis and Cochrane overview

    DEFF Research Database (Denmark)

    Singh, J. A.; Wells, G. A.; Christensen, Robin Daniel Kjersgaard


    Background Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since serious risks such as tuberculosis (TB) reactivation, serious...

  8. Gender Inequality in Biology Classes in China and Its Effects on Students' Short-Term Outcomes (United States)

    Liu, Ning; Neuhaus, Birgit


    This study investigated gender inequality in biology lessons and analysed the effects of the observed inequality on students' short-term knowledge achievement, situational interest and students' evaluation of teaching (SET). Twenty-two biology teachers and 803 7th-grade students from rural and urban classrooms in China participated in the study.…

  9. A Study of the Probe Effect on the Apparent Image of Biological Atomic Force Microscopy

    Institute of Scientific and Technical Information of China (English)


    The probe effect on the apparent image of biological atomic force microscopy was explored in this study, and the potential of AFM in conformational study of gene related biological processes was illustrated by the specific nanostructural information of a new antitumor drug binding to DNA.

  10. Indirect ecological effects in invaded landscapes: Spillover and spillback from biological control agents to native analogues (United States)

    Biological control remains an effective option for managing large-scale weed problems in natural areas. The predation or parasitism of biological control agents by other species present in the introduced range (biotic resistance) is well studied and is often cited as the cause for a lack of establis...

  11. Biological Effects of TMPRSS2/ERG Fusion Isoforms in Human Prostate Cancer (United States)


    TITLE: Biological Effects of TMPRSS2/ERG Fusion Isoforms in Human Prostate Cancer PRINCIPAL INVESTIGATOR: Jianghua Wang, M.D...6 JAN 2009 / / /4. TITLE AND SUBTITLE Biological Effects of TMPRSS2/ERG Fusion Isoforms in Human Prostate Cancer 5a. CONTRACT NUMBER W81XWH...quantitative RT-PCR arrays we have identified candidate mediators of these phenotypic effects . We propose to extend these studies to primary prostate epithelial

  12. Integrated Network Analysis and Effective Tools in Plant Systems Biology

    Directory of Open Access Journals (Sweden)

    Atsushi eFukushima


    Full Text Available One of the ultimate goals in plant systems biology is to elucidate the genotype-phenotype relationship in plant cellular systems. Integrated network analysis that combines omics data with mathematical models has received particular attention. Here we focus on the latest cutting-edge computational advances that facilitate their combination. We highlight (1 network visualization tools, (2 pathway analyses, (3 genome-scale metabolic reconstruction, and (4 the integration of high-throughput experimental data and mathematical models. Multi-omics data that contain the genome, transcriptome, proteome, and metabolome and mathematical models are expected to integrate and expand our knowledge of complex plant metabolisms.

  13. Biological influences on hydrogen effects in steel in seawater

    Energy Technology Data Exchange (ETDEWEB)

    Edyvean, R.G.J.; Benson, J.; Thomas, C.J. [Univ. of Sheffield (United Kingdom). Dept. of Chemical and Process Engineering; Beech, I.B. [Univ. of Portsmouth (United Kingdom). Dept. of Chemistry; Videla, H.A. [Univ. of La Plata (Argentina). Dept. of Chemistry


    Conditions conducive to the enhancement of corrosion-fatigue crack growth and of hydrogen embrittlement can be generated by the activity of sulfate-reducing bacterial. However, while the presence of bacteria encourages more hydrogen entry into susceptible metals when compared to similar levels of sulfide generated abiotically, corrosion-fatigue crack growth rates are slower in biological environments than the equivalent abiological environment. These results are discussed in the light of recent findings on the enhancement and inhibition of surface corrosion by bacterial biofilms.

  14. School Uniforms: Esprit de Corps. (United States)

    Ryan, Rosemary P.; Ryan, Thomas E.


    The benefits of school uniforms far outweigh their short-term costs. School uniforms not only keep students safe, but they increase their self-esteem, promote a more positive attitude toward school, lead to improved student behavior, and help blur social-class distinctions. Students are allowed to wear their own political or religious messages,…

  15. Biological effects of an impulse current according to laboratory researches of electroshock devices

    Directory of Open Access Journals (Sweden)

    Grigoryev О.A.


    Full Text Available The federal law "About Weapons" permits the use of electroshock devices if they are safe for people. We developed requirements for the procedure medical-biological testing on the safety of electroshock devices. We did an experimental study assessing medical-biological safety of electroshock devices. The assessment is based on a point system, which use ranges of biological effects. The experiments were performed in rabbits. We used 13 electroshock devices with different characteristics. Electroshock devices were made in Russia. We found that the response of a biological object to inrush current included convulsions, respiratory and cardiac activity. We analyzed the biological effects of pulsed current electroshock device obtained in experimental conditions. It is concluded that the characteristic clinical and physiological response to the action of electric current is pulsepolyparametric and depending on a combination of characteristics and condition of the electric impulse influence object.

  16. Effects of Oxidative Stress on Mesenchymal Stem Cell Biology (United States)


    Mesenchymal stromal/stem cells (MSCs) are multipotent stem cells present in most fetal and adult tissues. Ex vivo culture-expanded MSCs are being investigated for tissue repair and immune modulation, but their full clinical potential is far from realization. Here we review the role of oxidative stress in MSC biology, as their longevity and functions are affected by oxidative stress. In general, increased reactive oxygen species (ROS) inhibit MSC proliferation, increase senescence, enhance adipogenic but reduce osteogenic differentiation, and inhibit MSC immunomodulation. Furthermore, aging, senescence, and oxidative stress reduce their ex vivo expansion, which is critical for their clinical applications. Modulation of sirtuin expression and activity may represent a method to reduce oxidative stress in MSCs. These findings have important implications in the clinical utility of MSCs for degenerative and immunological based conditions. Further study of oxidative stress in MSCs is imperative in order to enhance MSC ex vivo expansion and in vivo engraftment, function, and longevity. PMID:27413419

  17. Biological methanogenesis and the CO2 greenhouse effect (United States)

    Guthrie, P. D.


    It is well established that plants tend to increase net photosynthesis under increased carbon dioxide. It is also well established that a large fraction of atmospheric methane is produced by microbial metabolism of organic sediments in paddies and freshwater wetlands, where a major source of organic debris is local plant growth. As CO2 increases, it may lead to increased methane production and a resulting enhancement of the expected greenhouse warming. A rough estimate of the present rate of this biologically mediated feedback on the climate system indicates that it might account for as much as 30 percent of the observed methane increase and speed up the greenhouse forcing by as much as 15 percent.

  18. Dehydroepiandrosterone biosynthesis, metabolism, biological effects, and clinical use (analytical review

    Directory of Open Access Journals (Sweden)

    N. P. Goncharov


    Full Text Available The review presents the fundamental information on the metabolism of dehydroepiandrosterone (DHEA, its biological role and possibilities of its use for replacement therapy. There were studied species differences in the synthesis of DHEA in the adrenal cortex. It was found that DHEA and DHEA-sulfate are produced only by the adrenal glands of humans and monkeys, including lower monkeys. Their biosynthesis involves the following steps: cholesterol → pregnenolone → 17-hydroxypregnenolone → DHEA. The adrenal glands of other species, including rats and mice do not synthesize DHEA. At the same time, in certain brain structures not only in man and monkey, but also in other animals DHEA and its precursors are synthesized de novo which are denoted as neurosteroids. It was demonstrated that Purkinje cells which play an important role in memory formation and learning are mainly place neurosteroid formation in mammals and other vertebrates. To establish the relationship of age and the level of DHEA and other steroids we studied the dynamics of their levels at different periods of postnatal development of people. Peak concentration DHEA observed in aged 25–30 years. In the interval from 20 to 90 years in humans the level falls approximately for 90 %. Cortisol levels in blood does not vary with age, leading to an imbalance in the ratio of cortisol/DHEA. Proved a major role of DHEA as a source (precursor for the synthesis of biologically active sex steroids – testosterone, estradiol and estrone in peripheral tissues. This review presents the bioavailability of DHEA in various physiological and pathological processes in humans and animals. In animal experiments has shown a higher bioavailability of DHEA in transdermal administration as compared with oral administration as in this case there is no steroid rapid inactivation in the liver during its first passage. According to recent studies there is a pronounced dependence of bioavailability of DHEA

  19. Dehydroepiandrosterone biosynthesis, metabolism, biological effects, and clinical use (analytical review

    Directory of Open Access Journals (Sweden)

    N. P. Goncharov


    Full Text Available The review presents the fundamental information on the metabolism of dehydroepiandrosterone (DHEA, its biological role and possibilities of its use for replacement therapy. There were studied species differences in the synthesis of DHEA in the adrenal cortex. It was found that DHEA and DHEA-sulfate are produced only by the adrenal glands of humans and monkeys, including lower monkeys. Their biosynthesis involves the following steps: cholesterol → pregnenolone → 17-hydroxypregnenolone → DHEA. The adrenal glands of other species, including rats and mice do not synthesize DHEA. At the same time, in certain brain structures not only in man and monkey, but also in other animals DHEA and its precursors are synthesized de novo which are denoted as neurosteroids. It was demonstrated that Purkinje cells which play an important role in memory formation and learning are mainly place neurosteroid formation in mammals and other vertebrates. To establish the relationship of age and the level of DHEA and other steroids we studied the dynamics of their levels at different periods of postnatal development of people. Peak concentration DHEA observed in aged 25–30 years. In the interval from 20 to 90 years in humans the level falls approximately for 90 %. Cortisol levels in blood does not vary with age, leading to an imbalance in the ratio of cortisol/DHEA. Proved a major role of DHEA as a source (precursor for the synthesis of biologically active sex steroids – testosterone, estradiol and estrone in peripheral tissues. This review presents the bioavailability of DHEA in various physiological and pathological processes in humans and animals. In animal experiments has shown a higher bioavailability of DHEA in transdermal administration as compared with oral administration as in this case there is no steroid rapid inactivation in the liver during its first passage. According to recent studies there is a pronounced dependence of bioavailability of DHEA

  20. Sequestration of mitochondrial iron by silica particles initiates a biological effect. (United States)

    Summary Inhalation of particulate matter has presented a challenge to human health for thousands of years. The underlying mechanism for biological effect following particle exposure is incompletely understood. We tested the postulate that particle sequestration of cell and mit...

  1. Principle of uniformity of temperature difference field in heat exchanger

    Institute of Scientific and Technical Information of China (English)

    过增元; 李志信; 周森泉; 熊大曦


    A principle of uniformity of temperature difference field (TDF) in heat exchangers is advanced.It states that the more uniform the temperature difference field,the higher the effectiveness of heat exchanger for a given NTU and C,.Analytical and numerical results on the uniformity of TDF and effectiveness of thirteen types of heat exchangers show the validity of the uniformity principle.Its further verification is given by the asymptotical solution of TDF in terms of a recurrence formula of heat transfer area distribution.The analyses of entropy generation caused by heat transfer indicate that the uniformity principle is based on the second law of thermodynamics.Two ways,redistributing heat transfer areas and varying the connection between tubes,are presented for the improvement of the uniformity of TDF and the consequent increase of effectiveness for crossflow heat exchangers.

  2. Glyphosate accumulation, translocation, and biological effects in Coffea arabica after single and multiple exposures

    DEFF Research Database (Denmark)

    Schrübbers, Lars Christoph; Valverde, Bernal E.; Strobel, Bjarne W.


    . In this study, we investigated glyphosate translocation over time, and its concentration and biological effects after single and multiple simulated spray-drift exposures. Additionally, shikimic acid/glyphosate ratios were used as biomarkers for glyphosate binding to its target enzyme.Four weeks after...... of application, however, was more important regarding biological effects than the number of applications both in the greenhouse and in the field. In the field, berry yield, the most important biological response variable, was reduced 26% by the first out of four sequential applications of glyphosate at 64 g a...

  3. Professional development strategies for teaching urban biology teachers to use concept maps effectively (United States)

    McGregor Petgrave, Dahlia M.

    Many teachers are not adequately prepared to help urban students who have trouble understanding conceptual ideas in biology because these students have little connection to the natural world. This study explored potential professional development strategies to help urban biology teachers use concept maps effectively with various topics in the biology curriculum. A grounded theory approach was used to develop a substantive professional development model for urban biology teachers. Qualitative data were collected through 16 semi-structured interviews of professional developers experienced in working with concept maps in the urban context. An anonymous online survey was used to collect quantitative data from 56 professional developers and teachers to support the qualitative data. The participants were from New York City, recruited through the NY Biology-Chemistry Professional Development Mentor Network and the NY Biology Teachers' Association. According to the participants, map construction, classroom applications, lesson planning, action research, follow-up workshops, and the creation of learning communities are the most effective professional development strategies. The interviewees also proposed English language learning strategies such as picture maps, native word maps, and content reading materials with underlined words. This study contributes to social change by providing a professional development model to use in planning workshops for urban teachers. Urban teachers improve their own conceptual understanding of biology while learning how to implement concept mapping strategies in the classroom. Students whose teachers are better prepared to teach biology in a conceptual manner have the potential of growing into more scientifically literate citizens.

  4. Bioaccumulation and biological effects in the earthworm Eisenia fetida exposed to natural and depleted uranium

    Energy Technology Data Exchange (ETDEWEB)

    Giovanetti, Anna, E-mail: anna.giovanetti@enea.i [ENEA, Institute of Radiation Protection, CR Casaccia Via Anguillarese 301, 00123 Rome (Italy); Fesenko, Sergey [International Atomic Energy Agency (IAEA), Agency' s Laboratories Seibersdorf, A-2444 Seibersdorf (Austria); Cozzella, Maria L. [ENEA, National Institute for Metrology of Ionizing Radiation, CR Casaccia Via Anguillarese 301, 00123 Rome (Italy); Asencio, Lisbet D. [Centro de Estudios Ambientales, Carretera a Castillo de Jagua, CP. 59350 C. Nuclear, Cienfuegos (Cuba); Sansone, Umberto [International Atomic Energy Agency (IAEA), Agency' s Laboratories Seibersdorf, A-2444 Seibersdorf (Austria)


    The accumulations of both natural (U) and depleted (DU) uranium in the earthworms (Eisenia fetida) were studied to evaluate corresponding biological effects. Concentrations of metals in the experimental soil ranged from 1.86 to 600 mg kg{sup -1}. Five biological endpoints: mortality, animals' weight increasing, lysosomal membrane stability by measuring the neutral red retention time (the NRRT), histological changes and genetic effects (Comet assay) were used to evaluate biological effects in the earthworms after 7 and 28 days of exposure. No effects have been observed in terms of mortality or weight reduction. Cytotoxic and genetic effects were identified at quite low U concentrations. For some of these endpoints, in particular for genetic effects, the dose (U concentration)-effect relationships have been found to be non-linear. The results have also shown a statistically significant higher level of impact on the earthworms exposed to natural U compared to depleted U.

  5. Uniform Acceleration in General Relativity

    CERN Document Server

    Friedman, Yaakov


    We extend de la Fuente and Romero's defining equation for uniform acceleration in a general curved spacetime from linear acceleration to the full Lorentz covariant uniform acceleration. In a flat spacetime background, we have explicit solutions. We use generalized Fermi-Walker transport to parallel transport the Frenet basis along the trajectory. In flat spacetime, we obtain velocity and acceleration transformations from a uniformly accelerated system to an inertial system. We obtain the time dilation between accelerated clocks. We apply our acceleration transformations to the motion of a charged particle in a constant electromagnetic field and recover the Lorentz-Abraham-Dirac equation.

  6. III. Biological effects of radiation from external and internal sources

    Energy Technology Data Exchange (ETDEWEB)

    Stone, R.S.


    This report focuses on the hemotological effects of total body irradiation from external and internal sources observed in patients treated for arthritis with radioactive phosphorus administered intravenously.

  7. Soil degradation effect on biological activity in Mediterranean calcareous soils (United States)

    Roca-Pérez, L.; Alcover-Sáez, S.; Mormeneo, S.; Boluda, R.


    Soil degradation processes include erosion, organic matter decline, compaction, salinization, landslides, contamination, sealing and biodiversity decline. In the Mediterranean region the climatological and lithological conditions, together with relief on the landscape and anthropological activity are responsible for increasing desertification process. It is therefore considered to be extreme importance to be able to measure soil degradation quantitatively. We studied soil characteristics, microbiological and biochemical parameters in different calcareous soil sequences from Valencia Community (Easter Spain), in an attempt to assess the suitability of the parameters measured to reflect the state of soil degradation and the possibility of using the parameters to assess microbiological decline and soil quality. For this purpose, forest, scrubland and agricultural soil in three soil sequences were sampled in different areas. Several sensors of the soil biochemistry and microbiology related with total organic carbon, microbial biomass carbon, soil respiration, microorganism number and enzyme activities were determined. The results show that, except microorganism number, these parameters are good indicators of a soil biological activity and soil quality. The best enzymatic activities to use like indicators were phosphatases, esterases, amino-peptidases. Thus, the enzymes test can be used as indicators of soil degradation when this degradation is related with organic matter losses. There was a statistically significant difference in cumulative O2 uptake and extracellular enzymes among the soils with different degree of degradation. We would like to thank Spanish government-MICINN for funding and support (MICINN, project CGL2006-09776).

  8. Modelling beam transport and biological effectiveness to develop treatment planning for ion beam radiotherapy

    CERN Document Server

    Grzanka, Leszek


    Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical prescription, finds the optimum distribution of cancer cells to be inactivated by their irradiation over the tumour volume, is a basic procedure of cancer radiotherapy. The main difficulty encountered in therapy planning for ion radiotherapy is to correctly account for the enhanced radiobiological effectiveness of ions in the Spread Out Bragg Peak (SOBP) region over the tumour volume. In this case, unlike in conventional radiotherapy with photon beams, achieving a uniform dose distribution over the tumour volume does not imply achieving uniform cancer cell inactivation. In this thesis, an algorithm of the basic element (kernel) of a treatment planning system (TPS) for carbon ion therapy is developed. The algorithm consists of a radiobiological part which suitably corrects for ...

  9. Sckool Dress Rule, Uniform Policies

    Institute of Scientific and Technical Information of China (English)



    Our schools believe that a uniform policy will provide a better environment, promote positive selfesteem, encourage an atmosphere for greater discipline, and increase learning opportunities for students by removing many of the distractions associated with various types of clothing.

  10. Uniform polyhedra: old and new

    CERN Document Server

    Melikhov, Sergey A


    We develop a theory of metric polyhedra, including locally infinite dimensional ones. Motivated by algebraic topology, we focus on their uniform properties (i.e., those preserved by homeomorphisms that are uniformly continuous in both directions) but in doing so we also study their metric and Lipschitz properties. On the combinatorial side, (the face posets of) simplicial or cubical complexes do not suffice for this, and we have to rework some basic PL topology into a purely combinatorial machinery (with all homeomorphisms eliminated in favor of combinatorial isomorphisms) based on posets and their canonical subdivision (which is just the poset of all order intervals of the given poset, ordered by inclusion). Antecedents of this approach to PL topology are found in van Kampen's 1929 dissertation and in modern Topological Combinatorics. Our main results establish, in particular, close but troubled relations between uniform polyhedra and uniform ANRs, and appear to provide a satisfactory solution to an open-end...

  11. Landing the uniformly accelerating observers


    Rothenstein, Bernhard; Popescu, Stefan; Gruber, Ronald P.


    Observers of the uniformly accelerating observers or the observers who make up the system of uniformly accelerating observers reach the same velocity V at different times ti which depends on V and on theirs acceleration gi. Considering a platform that moves with constant velocity V, the observers can land smoothly on it. Their ages and locations in the inertial reference frame attached to the platform are reckoned and compared.

  12. The biological effects of five feline IFN-alpha subtypes. (United States)

    Baldwin, Susan L; Powell, Tim D; Sellins, Karen S; Radecki, Steven V; Cohen, J John; Milhausen, Michael J


    IFN-alpha has been shown to induce both antiviral and antiproliferative activities in animals. This report describes the biological activity of five recently identified feline IFN-alpha subtypes expressed in the Chinese hamster ovary (CHO) cell line (rfeIFN-alpha1[CHO], rfeIFN-alpha2[CHO], rfeIFN-alpha3[CHO], rfeIFN-alpha5[CHO] and rfeIFN-alpha6[CHO]) and the feIFN-alpha6 subtype expressed in and purified from Pichia pastoris (rfeIFN-alpha6[P. pastoris]). The rfeIFN-alpha[CHO] subtypes were tested for antiviral activity against either Vesicular stomatitis virus (VSV) or feline calicivirus (FCV) infected feline embryonic fibroblast cell line (AH927) or Crandell feline kidney cell line (CRFK). Antiviral activity was induced against both VSV and FCV infected AH927 cells and VSV infected CRFK cells by all five of the rfeIFN-alpha[CHO] subtypes and rfeIFN-alpha6[P. pastoris]. In addition, the IFN-alpha inducible Mx gene (associated with antiviral activity) was upregulated in vivo 24 h following treatment with rfeIFN-alpha6[P. pastoris], compared to baseline levels seen prior to treatment. All of the rfeIFN-alpha[CHO] subtypes and rfeIFN-alpha6[P. pastoris] exhibited antiproliferative activity in the FeT-J cell line (an IL-2 independent feline T-cell line). Both necrosis and apoptosis were observed in rfeIFN-alpha6[P. pastoris]-treated FeT-J cells. The rfeIFN-alpha3[CHO] subtype consistently exhibited lower antiviral and antiproliferative activity compared to that observed with the other four rfeIFN-alpha[CHO] subtypes. In summary, this paper demonstrates that five previously described feIFN-alpha subtypes induce both antiviral and antiproliferative activities in vitro and are capable of upregulating the feMx gene in vivo.

  13. Psychological Effects towards Humans Living in the Environment Made of Biological Concrete in Malaysia at 2015

    Directory of Open Access Journals (Sweden)

    Amirreza Talaiekhozani


    Full Text Available In day-to-day life concrete become a compulsory material in the construction field as to make it a real concern among researchers for producing concrete with improved properties. Biological method is one of the new methods to improve concrete properties. Although, much research about biological concrete has been carried out, but till now nobody has not studied for the psychological effects of using a house or offices made up of biological concrete. The aim of this study is to investigate and find out the person's opinion about staying in a house or offices made up of biological concrete. In this study, a questionnaire containing eight questions was prepared and distributed among 21 persons in Malaysia University of Technology including students, academic and non-academic staffs among which few of them was an expert in the field of biological concrete and others did not have any knowledge about the bioconcrete. Finally, the results obtained from the questionnaires were analyzed. The results showed that 81% of participants in this study would like to stay in a house or office made up of biological concrete. However, 38% of participants believe that staying in a house or office made of biological concrete can cause health related problems. The current research paper can be considered significant for architects and civil engineers to have the insight to look into the psychological aspects of using biological concrete for various applications in the field of construction.



    Kopylov, Alexei; Kruglik, Olga; Khlebopros, Rem


    This research is concerned with development of the microwave system for research the radiophysical microwave radiation effects on laboratory animals. The frequency was 1 GHz. The results obtained demonstrate the metabolic changes in mice under the electromagnetic field influence.

  15. A theoretical framework for biological control of soil-borne plant pathogens: Identifying effective strategies. (United States)

    Cunniffe, Nik J; Gilligan, Christopher A


    We develop and analyse a flexible compartmental model of the interaction between a plant host, a soil-borne pathogen and a microbial antagonist, for use in optimising biological control. By extracting invasion and persistence thresholds of host, pathogen and biological control agent, performing an equilibrium analysis, and numerical investigation of sensitivity to parameters and initial conditions, we determine criteria for successful biological control. We identify conditions for biological control (i) to prevent a pathogen entering a system, (ii) to eradicate a pathogen that is already present and, if that is not possible, (iii) to reduce the density of the pathogen. Control depends upon the epidemiology of the pathogen and how efficiently the antagonist can colonise particular habitats (i.e. healthy tissue, infected tissue and/or soil-borne inoculum). A sharp transition between totally effective control (i.e. eradication of the pathogen) and totally ineffective control can follow slight changes in biologically interpretable parameters or to the initial amounts of pathogen and biological control agent present. Effective biological control requires careful matching of antagonists to pathosystems. For preventative/eradicative control, antagonists must colonise susceptible hosts. However, for reduction in disease prevalence, the range of habitat is less important than the antagonist's bulking-up efficiency.

  16. Effect of solids retention time and wastewater characteristics on biological phosphorus removal

    DEFF Research Database (Denmark)

    Henze, Mogens; Aspegren, H.; Jansen, J.l.C.


    The paper deals with the effect of wastewater, plant design and operation in relation to biological nitrogen and phosphorus removal and the possibilities to model the processes. Two Bio-P pilot plants were operated for 2.5 years in parallel receiving identical wastewater. The plants had SRT of 4...... with time which has importance in relation to modelling. The overall conclusion of the comparison between the two plants is that the biological phosphorus removal efficiency under practical operating conditions is affected by the SRT in the plant and the wastewater composition. Thus great care should...... in verification of models for Nitrogen and Enhanced Biological Phosphorus Removal....

  17. Which chemicals drive biological effects in wastewater and recycled water? (United States)

    Tang, Janet Y M; Busetti, Francesco; Charrois, Jeffrey W A; Escher, Beate I


    Removal of organic micropollutants from wastewater during secondary treatment followed by reverse osmosis and UV disinfection was evaluated by a combination of four in-vitro cell-based bioassays and chemical analysis of 299 organic compounds. Concentrations detected in recycled water were below the Australian Guidelines for Water Recycling. Thus the detected chemicals were considered not to pose any health risk. The detected pesticides in the wastewater treatment plant effluent and partially advanced treated water explained all observed effects on photosynthesis inhibition. In contrast, mixture toxicity experiments with designed mixtures containing all detected chemicals at their measured concentrations demonstrated that the known chemicals explained less than 3% of the observed cytotoxicity and less than 1% of the oxidative stress response. Pesticides followed by pharmaceuticals and personal care products dominated the observed mixture effects. The detected chemicals were not related to the observed genotoxicity. The large proportion of unknown toxicity calls for effect monitoring complementary to chemical monitoring.

  18. Biological effects of lysophosphatidic acid in the nervous system. (United States)

    Frisca, Frisca; Sabbadini, Roger A; Goldshmit, Yona; Pébay, Alice


    Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.

  19. Electrical and Biological Effects of Transmission Lines: A Review.

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jack M.


    This review describes the electrical properties of a-c and d-c transmission lines and the resulting effects on plants, animals, and people. Methods used by BPA to mitigate undesirable effects are also discussed. Although much of the information in this review pertains to high-voltage transmission lines, information on distribution lines and electrical appliances is included. The electrical properties discussed are electric and magnetic fields and corona: first for alternating-current (a-c) lines, then for direct current (d-c).

  20. Some features of irradiated chitosan and its biological effect

    Energy Technology Data Exchange (ETDEWEB)

    Hai, Le; Hien, Nguyen Quoc; Luan, Le Quang; Hanh, Truong Thi; Man, Nguyen Tan; Ha, Pham Thi Le; Thuy, Tran Thi [Nuclear Research Institute, VAEC, Dalat (Viet Nam); Yoshii, Fumio; Kume, Tamikazu [Japan Atomic Energy Research Inst., Takasaki, Gunma (Japan). Takasaki Radiation Chemistry Research Establishment


    Preparation of chitosan oligomer by radiation degradation was carried out on the gamma Co-60 source. The radiation degradation yield (G{sub d}) of the chitosan was found to be of 1.03. The oligochitosan with 50% of dp>8 fraction was obtained by irradiating the 10% (w/v) chitosan solution in 5% acetic acid at 45 kGy for the chitosan having the initial viscometric average molecular weight, Mv=60,000. Irradiated chitosan showed higher antifungal effect than that of unirradiated one. Furthermore, the irradiated chitosan also showed the growth-promotion effect for plants. (author)

  1. Physical optics in a uniform gravitational field (United States)

    Hacyan, Shahen


    The motion of a (quasi-)plane wave in a uniform gravitational field is studied. It is shown that the energy of an elliptically polarized wave does not propagate along a geodesic, but in a direction that is rotated with respect to the gravitational force. The similarity with the walk-off effect in anisotropic crystals or the optical Magnus effect in inhomogeneous media is pointed out.

  2. Nanoscaled biological gated field effect transistors for cytogenetic analysis

    DEFF Research Database (Denmark)

    Kwasny, Dorota; Dimaki, Maria; Andersen, Karsten Brandt;


    Cytogenetic analysis is the study of chromosome structure and function, and is often used in cancer diagnosis, as many chromosome abnormalities are linked to the onset of cancer. A novel label free detection method for chromosomal translocation analysis using nanoscaled field effect transistors...

  3. Biological effects of ionizing radiations; Effets biologiques des rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Nenot, J.C. [CEA Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire]|[Commission Internationale de protection radiologique (France)]|[Association Internationale de Radiopathologie (France)


    Since ten years the ionizing radiations are more and more often used in various domains as medical, industrial or research sector. In the same way, these radiation impacts on the environment and the living organisms, have been studied intensively. The effects mechanism knowledge improved considerably and allowed to better protect the workers and the public. (A.L.B.)

  4. Biological Effects of Electromagnetic Fields on Cellular Growth (United States)

    Eftekhari, Beheshte; Wilson, James; Masood, Samina


    The interaction of organisms with environmental magnetic fields at the cellular level is well documented, yet not fully understood. We review the existing experimental results to understand the physics behind the effects of ambient magnetic fields on the growth, metabolism, and proliferation of in vitro cell cultures. Emphasis is placed on identifying the underlying physical principles responsible for alterations to cell structure and behavior.

  5. Resource Letter BELFEF-1: Biological effects of low-frequency electromagnetic fields (United States)

    Hafemeister, David


    This Resource Letter provides a guide to the literature on the interaction of extremely low-frequency electromagnetic field (ELF/EMF) interactions with biological matter, and on the possibility that such interactions could have a harmful effect on human health. Journal articles and books are cited for the following topics: ELF/EMF theoretical interactions with biological cells, organs and organisms, magnetic dipole interactions, sensing by animals, biomedical-biophysical experiments, epidemiology, and litigation-mitigation risk issues.

  6. The influence of local effects on thermal sensation under non-uniform environmental conditions — Gender differences in thermophysiology, thermal comfort and productivity during convective and radiant cooling

    DEFF Research Database (Denmark)

    Schellen, L.; Loomans, M.G.L.C.; de Wit, M.H.;


    , thermal comfort and productivity in response to thermal non-uniform environmental conditions. Twenty healthy subjects (10 males and 10 females, age 20–29years) were exposed to two different experimental conditions: a convective cooling situation (CC) and a radiant cooling situation (RC). During...... the experiments physiological responses, thermal comfort and productivity were measured. The results show that under both experimental conditions the actual mean thermal sensation votes significantly differ from the PMV-index; the subjects are feeling colder than predicted. Furthermore, the females are more...

  7. Biological activities and health effects of terpenoids from marine fungi. (United States)

    Kim, Se-Kwon; Li, Yong-Xin


    Recently, a great deal of interest has been developed by the consumers toward natural bioactive compounds as functional ingredients in the nutraceutical, cosmeceutical, and pharmaceutical products due to their various health beneficial effects. Hence, it can be suggested that bioactive functional ingredients from marine bioresources and their by-products are alternative sources for synthetic ingredients that can contribute to consumer's well-being, as a part of nutraceuticals and functional foods. Marine-derived fungi produce a vast array of secondary metabolites including terpenes, steroids, polyketides, peptides, alkaloids, and polysaccharides. These secondary metabolites serve many biopharmaceutical purposes. This chapter discusses about marine fungi-derived terpenoids and presents an overview of their beneficial health effects.

  8. Biological Effects of Nonionizing Electromagnetic Radiation. Volume IV. Number 3. (United States)


    teratogenesis in mealworms (9-10 GHz at total power CENTRAL NERVOUS SYSTEM, BEHAVIOR, AND of 20-80 mW) and in mice (2,450 MHz, energy absorp- BLOOD: A PROGRESS...behavioral changes, diseases are discussed and three case reports dem- malaise, restlessness, sterilization, fetal damage, onstrating this problem are...April, 1979. exposure of Moscow Embassy employees in the causa - (7 refs) tion of any adverse health effects. Four studies to determine the health

  9. Biologic Effects of Dopamine on Tumor Vasculature in Ovarian Carcinoma

    Directory of Open Access Journals (Sweden)

    Myrthala Moreno-Smith


    Full Text Available Chronic sympathetic nervous system activation results in increased angiogenesis and tumor growth in orthotopic mouse models of ovarian carcinoma. However, the mechanistic effects of such activation on the tumor vasculature are not well understood. Dopamine (DA, an inhibitory catecholamine, regulates the functions of normal and abnormal blood vessels. Here, we examined whether DA, an inhibitory catecholamine, could block the effects of chronic stress on tumor vasculature and tumor growth. Exogenous administration of DA not only decreased tumor microvessel density but also increased pericyte coverage of tumor vessels following daily restraint stress in mice. Daily restraint stress resulted in significantly increased tumor growth in the SKOV3ip1 and HeyA8 ovarian cancer models. DA treatment blocked stress-mediated increases in tumor growth and increased pericyte coverage of tumor endothelial cells. Whereas the antiangiogenic effect of DA is mediated by dopamine receptor 2 (DR2, our data indicate that DA, through DR1, stimulates vessel stabilization by increasing pericyte recruitment to tumor endothelial cells. DA significantly stimulated migration of mouse 10T1/2 pericyte-like cells in vitro and increased cyclic adenosine mono-phosphate (cAMP levels in these cells. Moreover, DA or the DR1 agonist SKF 82958 increased platinum concentration in SKOV3ip1 tumor xenografts following cisplatin administration. In conclusion, DA stabilizes tumor blood vessels through activation of pericyte cAMP-protein kinase A signaling pathway by DR1. These findings could have implications for blocking the stimulatory effects of chronic stress on tumor growth.


    Directory of Open Access Journals (Sweden)

    I. A. Orlovskaya


    Full Text Available Abstract. This review presents a summary of our data concerning in vivo and in vitro effects of recombinant TNF-binding protein from variola virus (VARVCrmB upon TNF-induced functional changes of human and murine cells. VARV-CrmB protein blocks TNF-induced production of IL-1β and IL-6 by human mononuclear cells, and their in vitro oxidation-related metabolic (OM activity. VARV-CrmB protein restores TNF-induced reduction of BFU-E+CFU-E colony-forming activity and normalizes TNF-induced effects upon CFU-GM formation in a colony-forming model of human and murine bone morrow cells (BMC. VARV-CrmB protein displays a pronounced in vivo alleviation of LPS-induced endotoxic shock symptoms in SPF BALB/C mice thus significantly increasing survival of experimental animals. Moreover, VARV-CrmBprotein decreases intensity of collagen-induced arthritis at early terms. Application of VARV-CrmB protein results in normalization of TNF-induced increase of migratory and OM activity of murine leukocytes, and exerts corrective effects upon colony-forming ability of murine hematopoietic precursors. Skin application of VARV-CrmB protein decreases leukocyte migration from a skin scrap in afferent phase of DNCB-induced contact reaction, as well as “ear oedema” index. Our results demonstrate TNF-blocking properties of VARVCrmB protein. In summary, our data allow to consider a recombinant variola virus VARV-CrmB as a new potential TNF-antagonist. Its effects can be explained by its ability of neutralizing TNF-induced activation of oxidation-related metabolic, cytokine-producing and migratory functions of effector cells in therapy of pathological inflammatory processes.

  11. Radioactivity in the ocean: laws and biological effects

    Energy Technology Data Exchange (ETDEWEB)

    Hunsaker, C.T.


    This paper summarizes the literature on US laws and international agreements, experimental and monitoring data, and ongoing studies to provide background information for environmental assessment and regulatory compliance activities for ocean dumping of low-level radioactive waste. The Marine Protection, Research, and Sanctuaries Act is the major US legislation governing ocean disposal of radioactive waste. The major international agreement on ocean dumping is the Convention on the Prevention of Marine Pollution by Dumping of Wastes and other Matter. The United States ended its ocean dumping of radioactive wastes in 1970, but other countries have continued ocean dumping under international supervision in the northeast Atlantic. Monitoring of former US disposal sites has neither revealed significant effects on marine biota nor indicated a hazard to human health. Also, no effects on marine organisms have been found that could be attributed to routine discharges into the Irish Sea from the Windscale reprocessing plant. We must improve our ability to predict the oceanic carrying capacity and the fate and effects of ionizing radiation in the marine environment.

  12. Biological Effects of Culture Substrates on Human Pluripotent Stem Cells

    Directory of Open Access Journals (Sweden)

    Yohei Hayashi


    Full Text Available In recent years, as human pluripotent stem cells (hPSCs have been commonly cultured in feeder-free conditions, a number of cell culture substrates have been applied or developed. However, the functional roles of these substrates in maintaining hPSC self-renewal remain unclear. Here in this review, we summarize the types of these substrates and their effect on maintaining hPSC self-renewal. Endogenous extracellular matrix (ECM protein expression has been shown to be crucial in maintaining hPSC self-renewal. These ECM molecules interact with integrin cell-surface receptors and transmit their cellular signaling. We discuss the possible effect of integrin-mediated signaling pathways on maintaining hPSC self-renewal. Activation of integrin-linked kinase (ILK, which transmits ECM-integrin signaling to AKT (also known as protein kinase B, has been shown to be critical in maintaining hPSC self-renewal. Also, since naïve pluripotency has been widely recognized as an alternative pluripotent state of hPSCs, we discuss the possible effects of culture substrates and integrin signaling on naïve hPSCs based on the studies of mouse embryonic stem cells. Understanding the role of culture substrates in hPSC self-renewal and differentiation enables us to control hPSC behavior precisely and to establish scalable or microfabricated culture technologies for regenerative medicine and drug development.

  13. [Effects and Biological Response on Bioremediation of Petroleum Contaminated Soil]. (United States)

    Yang, Qian; Wu, Man-li; Nie, Mai-qian; Wang, Ting-ting; Zhang, Ming-hui


    Bioaugmentation and biostimulation were used to remediate petroleum-contaminated soil which were collected from Zichang city in North of Shaanxi. The optimal bioremediation method was obtained by determining the total petroleum hydrocarbon(TPH) using the infrared spectroscopy. During the bioremediation, number of degrading strains, TPH catabolic genes, and soil microbial community diversity were determined by Most Probable Number (MPN), polymerase chain reaction (PCR) combined agarose electrophoresis, and PCR-denaturing gradient electrophoresis (DGGE). The results in different treatments showed different biodegradation effects towards total petroleum hydrocarbon (TPH). Biostimulation by adding N and P to soils achieved the best degradation effects towards TPH, and the bioaugmentation was achieved by inoculating strain SZ-1 to soils. Further analysis indicated the positive correlation between catabolic genes and TPH removal efficiency. During the bioremediation, the number of TPH and alkanes degrading strains was higher than the number of aromatic degrading strains. The results of PCR-DGGE showed microbial inoculums could enhance microbial community functional diversity. These results contribute to understand the ecologically microbial effects during the bioremediation of petroleum-polluted soil.

  14. Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?

    Directory of Open Access Journals (Sweden)

    Jones G


    Full Text Available Graeme Jones, Erica Darian-Smith, Michael Kwok, Tania WinzenbergMenzies Research Institute, University of Tasmania, Tasmania, AustraliaAbstract: There have been substantial advances in the treatment of rheumatoid arthritis in recent years. Traditional disease-modifying antirheumatic drugs (DMARDs have been shown to have small effects on the progression of radiographic damage. This quantitative overview summarizes the evidence for biologic DMARDS and radiographic damage either alone or in combination with methotrexate. Two outcomes were used (standardized mean difference and odds of progression. A total of 21 trials were identified of which 18 had useable data. For biologic monotherapy, tocilizumab, adalimumab, and etanercept were significantly better than methotrexate, with tocilizumab ranking first in both outcomes while golimumab was ineffective in both outcomes. For a biologic in combination with methotrexate compared with methotrexate alone, most therapies studied (etanercept, adalimumab, infliximab, certolizumab, tocilizumab, and rituximab were effective at slowing X-ray progression using either outcome, with infliximab ranking first in both outcomes. The exceptions to this were golimumab (no effect on standardized mean difference and abatacept (no effect on odds of progression. This effect was additional to methotrexate; thus, the overall benefit is moderate to large in magnitude, which is clearly of major clinical significance for sufferers of rheumatoid arthritis and supports the use of biologic DMARDs in those with a poor disease prognosis.Keywords: rheumatoid, trials, meta-analysis, radiographs, biologic, disease-modifying antirheumatic drugs, DMARDs


    Directory of Open Access Journals (Sweden)

    Patrick Osawaru Ajaja,


    Full Text Available The major purpose of this study was to determine the effects of learning cycle as an instructional strategy on biology andchemistry students achievement. To guide this study, six research hypotheses were stated and tested at 0.05 level ofsignificance. The design of this study was 2x2x3x6 Pre-test Post-test non-equivalent control group quasi experimental design.These included two instructional groups (experimental and control groups, sex (male and female, repeated testing (Pre,Post and follow-up tests, and six weeks of experience. The samples of the study included six senior secondary schools, 112science students, and 12 biology and chemistry teachers. The instruments used for this study were: teacher’s questionnaireon knowledge and use of learning cycle (KULC; and Biology and Chemistry Achievement Test (BCAT. The data collected wereanalyzed with simple percentage, Analysis of Covariance (ANCOVA and student t-test statistics. The major findings of thestudy included that only 30.43% and 26.31% of biology and chemistry teachers have the knowledge that learning cycle is aninstructional method; all the biology and chemistry teachers sampled have never used learning cycle as an instructionalmethod; learning cycle had a significant effect on students achievement in biology and chemistry; students taught withlearning cycle significantly achieved better in biology/chemistry Post-test than those taught with lecture method; the posttestscores of students in the learning cycle group increased over the period of experience; non-significant difference in Posttestscores between males and females taught with learning cycle; non-significant interaction effect between method andsex on achievement; and a significant higher retention of biology and chemistry knowledge by students taught with learningcycle than those taught with lecture method. It was concluded that the method seems an appropriate instructional modelthat could be used to solve the problems of

  16. Biological effect of non-ionizing radiations on microorganisms

    Energy Technology Data Exchange (ETDEWEB)

    Shimizu, Kikuo; Yamamoto, Takayoshi [Osaka Univ., Radioisotope Research Center, Suita, Osaka (Japan); Nakaoka, Yasuo [Osaka Univ., Graduate School of Engineering Science, Department of Biophysical Engineering, Toyonaka, Osaka (Japan)


    We studied the effect of extremely low frequency magnetic fields (ELF-MF) of 60-Hz and 500 mT on the growth and the mutation frequency of the budding yeast S.cerevisiae and on the behavior of the ciliate Paramecium multimicronucleatum. The growth rate and mutation frequencies of several strains of S.cerevisiae (wild type and radiation sensitive mutants, rad or rev) were examined but no significant difference was observed. Moreover, the behavior of P.multimicronucleatum under the ELF-MF was examined. When exposed to a vertical field of 0.6 T, the cells accumulated at the upper end of the cuvette. (author)

  17. Biological effect markers for exposure to carcinogenic compound and their relevance for risk assessment

    NARCIS (Netherlands)

    Delft, J.H.M. van; Baan, R.A.; Roza, L.


    In this review data are summarized on biomarkers that are used for biological effect monitoring of human populations exposed to genotoxic carcinogens. The biomarkers are DNA and protein adducts and cytogenetic effects. Most of these biomarkers are relevant for the process of carcinogenesis. Emphasis

  18. Oil spills: Biological effects. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning the biological and ecological effects of oil spills. Citations discuss effects on microorganisms, plants, and animals. Damage assessment, ecological modeling, and environmental impact statements are included. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  19. Low power laser therapy — an introduction and a review of some biological effects


    Thiel, Haymo


    This report gives a brief introduction to the characteristics of therapeutic low power laser devices. Absorption, tissue penetration and physiological mechanisms of laser irradiation are discussed. The biological effects of low power laser light are reviewed in the areas of collagen metabolism, woundhealing, inflammation and pain control. Contraindications, precautions and side effects of low power laser irradiation are discussed.

  20. Catalytically and noncatalytically treated automobile exhaust: biological effects in rats

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, G.P. (Univ. of Cincinnati); Lewkowski, J.P.; Hastings, L.; Malanchuk, M.


    Chronic exposure to catalytically treated or noncatalytically treated automobile exhaust significantly depressed the spontaneous locomotor activity (SLA) of rats. Exposure to H/sub 2/SO/sub 4/ alone or CO at comparable levels did not alter the SLA. Exposure to noncatalytically treated exhaust resulted in significant reductions in growth rate and food and water intake. However, these effects were not evident in the exposure to catalytically treated exhaust or in the control H/sub 2/SO/sub 4/ and CO exposures. Blood acid-base analyses indicated that exposure to either catalytically treated exhaust or H/sub 2/SO/sub 4/ elicits a metabolic alkalosis, while exposure to CO alone results in a metabolic acidosis. All acid-base parameters were within the normal range several weeks after the termination of exposure.

  1. [Quality of interior air: biological contaminants and their effects on health; bioaerosols and gathering techniques]. (United States)

    Bălan, Gabriela


    Indoor Air Quality: biological contaminants and health effects; airborne organisms and sampling instruments. Biological contaminants include bacteria, molds, viruses, animal dander and cat saliva, house dust, mites, cockroaches and pollen. Symptoms of health problems caused by biological pollutants include sneezing, watery eyes, coughing, shortness of breath, dizziness, lethargy, fevers. Children, elderly people with breathing problems, allergies and lung diseases are particularly susceptible to disease-causing biological agents in the indoor air. It is convenient to consider microbiological samplers for collecting organisms in air as falling into several broad categories. Many popular microbiological air samplers use the principle of impaction to trap the organisms by impacting them directly on to agar. Further distinct groups are the impingers, which operate by impinging organisms into liquid.

  2. On topological spaces possessing uniformly distributed sequences

    CERN Document Server

    Bogachev, V I


    Two classes of topological spaces are introduced on which every probability Radon measure possesses a uniformly distributed sequence or a uniformly tight uniformly distributed sequence. It is shown that these classes are stable under multiplication by completely regular Souslin spaces

  3. [Adipogenic function and other biologic effects of insulin]. (United States)

    Pankov, Y A


    Studies on experimental animals with knockout of the insulin receptor gene Insr (in the whole body or in certain tissues) and/or related genes encoding proteins involved in realization of insulin signal transduction in target cells, have made an important contribution to the elucidation of insulin regulation of metabolism, particularly fat metabolism. Since the whole insulin secreted by b-cells, together with the products of gastrointestinal tract digestion of proteins, fats, and carbohydrates reach the liver, the latter is the first organ on which this hormone acts. The liver employs released amino acids for synthesis of proteins, including apoproteins for various lipoproteins. Glucose is used for synthesis of glycogen, fatty acids, and triglycerides, which enter all the organs in very low density lipoproteins (VLDL). The LIRKO mice with knockout of the Insr gene in the liver demonstrated inhibition of synthesis of macromolecular compounds from amino acids, glucose, and fatty acids. Low molecular weight substances demonstrated increased entry to circulation, and together with other disorders induced hyperglycemia. In LIRKO mice blood glucose levels and glucose tolerance demonstrated time-dependent normalization and at later stages the increase in glucose levels was replaced by hypoglycemia. These changes can be well explained if we take into consideration that one of the main functions of insulin consists in stimulation of energy accumulation by means of activation of triglyceride deposition in adipose tissue. FIRKO mice with selective knockout of adipose tissue Insr were characterized by decreased uptake of glucose in adipocytes, and its transformation into lipids. However, the level of body fat in animals remained normal, possibly due to preserved insulin receptor in the liver and insulin-induced activation of triglyceride production which maintained normal levels of body fat stores, the effective functioning of adipose tissue and secretion of leptin by

  4. Biologic effects of fenbendazole in rats and mice: a review. (United States)

    Villar, David; Cray, Carolyn; Zaias, Julia; Altman, Norman H


    This review summarizes findings from toxicologic, carcinogenic, immunologic, and metabolic studies on fenbendazole (FBZ). Currently, FBZ is used to treat or prevent pinworm outbreaks in laboratory rodents. Because antiparasitic treatments usually are not part of experimental designs, interactions from the medication on the outcomes of ongoing experiments are a concern. At therapeutic levels, FBZ does not alter the total content of cytochromes P450 but does induce certain hepatic cytochrome P450 isoforms, namely 1A1, 1A2, and 2B1. Although expressed constitutively at low or undetectable levels, these isoforms particularly are known for bioactivating a number of procarcinogens. Lifetime studies in rats have shown that FBZ is not a carcinogen but that it may behave as a tumor promoter when given after certain initiators. Unlike in other animal species, FBZ treatment-associated myelosuppression has not been reported to occur in rodents. The few currently available immunologic studies in mice, including an autoimmune model, have not shown effects on selected immune responses. However, data from other animal species suggest that the ability of B and T lymphocytes to proliferate in the secondary immune response may be suppressed during treatment with FBZ.

  5. Cardiometabolic risk in psoriasis: differential effects of biologic agents

    Directory of Open Access Journals (Sweden)

    Mariana J Kaplan


    Full Text Available Mariana J KaplanDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USAAbstract: Psoriasis is associated to an increased risk of cardiovascular (CV complications. Overall, the pathogenic mechanisms involved in premature CV complications in psoriasis appear to be complex and multifactorial, with traditional and nontraditional risk factors possibly contributing to the increased risk. Based on what is known about the pathogenesis of psoriasis and extrapolating the current knowledge on CV complications in other inflammatory diseases, studies are needed to investigate if appropriate control of the inflammatory, immunologic and metabolic disturbances present in psoriasis can prevent the development of this potentially lethal complication. It is clear that there is a great need for heightened awareness of the increased risk for vascular damage in patients with psoriasis. It is also crucial to closely monitor patients with psoriasis for CV risk factors including obesity, hypertension, diabetes, and hyperlipidemia. Whether treatment regimens that effectively manage systemic inflammation will lead to prevention of CV complications in psoriasis needs to be investigated. Clearly, studies should focus on establishing the exact mechanisms that determine CV risk in psoriasis so that appropriate preventive strategies and treatment guidelines can be established.Keywords: psoriasis, atherosclerosis, inflammation, vascular

  6. The biological effect and medical functions of the Infrared Rays

    Institute of Scientific and Technical Information of China (English)

    PANG Xiao-feng


    The quantum vibrational energy-spectra including high excited states of the protein molecules have been calculated by new theory of bio-energy transport along the protein molecules and its dynamic equation, discrete nonlinear Schrodinger equation, appropriate to the protein molecules on the basis of the level of molecular structure. This energy-spectra obtained are basically consistent with the experimental values by infrared absorption and radiated measurement of person's hands and laser-Raman spectrum from metabolically active E. Coli.. From this energy-spectra we know that the infrared lights with (1-3)x1000nm and (5-7)x1000nm wavelength can be absorbed by the protein molecules in the living systems.In accordance with the non-linear theory of the bio-energy transport we know that the energy of the infrared light absorbed by the proteins can result in vibrations of amide-I in amino acids and can facilitate the bio-energy transport along the protein molecular chains from one place to other for the growth of living bodies. This processe is non-thermal. This is just non-thermal effect of the infrared lights. According to the mechanism we explained further the medical functions of the infrared lights absorbed.

  7. Biological effects of exposure to intermediate neutron and repair mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Utsumi, Hiroshi; Sasaki, Masao [Kyoto Univ. (Japan); Onishi, Takeo; Onizuka, Masahiko


    An investigation was made on cytotoxic effects of neutron capture using chicken B-cell line mutants, DT40, KURO{sup -/-}, RAD54 {sup -/-} and KU70{sup -/-} / RAD54{sup -/-}. Suspensions of these cells were exposed to two times X-radiation at various doses and the cell surviving was evaluated. The sensitivity to radiation was highest in the double defective mutant, KU70{sup -/-} / RAD54{sup -/-} and followed by that of RAD54 {sup -/-}, a homologous recombination mutant, whereas KURO {sup -/-} cell, a non-homologous end-joining mutant showed a peculiar surviving curve composed of two phases and the cell was highly sensitive to a low-dose radiation. This indicates that there are two different DNA repair systems for double-strand breaks and the system for non-homologous end-joining repair can be involved in all phases of cell cycle, but the system for the homologous one is involved only in S-phase. Therefore, it was thought that variation of sensitivity to radiation exposure depending to the phase of cell cycle might explain the alternation of repair system depending to the phase progressing of cell cycle. It was thus likely that the recovery from radiation injury, which is still a black box might be explained with the double strand breaks of DNA. (M.N.)

  8. Bioaccumulation and biological effects of cigarette litter in marine worms (United States)

    Wright, Stephanie L.; Rowe, Darren; Reid, Malcolm J.; Thomas, Kevin V.; Galloway, Tamara S.


    Marine debris is a global environmental issue. Smoked cigarette filters are the predominant coastal litter item; 4.5 trillion are littered annually, presenting a source of bioplastic microfibres (cellulose acetate) and harmful toxicants to marine environments. Despite the human health risks associated with smoking, little is known of the hazards cigarette filters present to marine life. Here we studied the impacts of smoked cigarette filter toxicants and microfibres on the polychaete worm Hediste diversicolor (ragworm), a widespread inhabitant of coastal sediments. Ragworms exposed to smoked cigarette filter toxicants in seawater at concentrations 60 fold lower than those reported for urban run-off exhibited significantly longer burrowing times, >30% weight loss, and >2-fold increase in DNA damage compared to ragworms maintained in control conditions. In contrast, ragworms exposed to smoked cigarette filter microfibres in marine sediment showed no significant effects. Bioconcentration factors for nicotine were 500 fold higher from seawater than from sediment. Our results illustrate the vulnerability of organisms in the water column to smoking debris and associated toxicants, and highlight the risks posed by smoked cigarette filter debris to aquatic life. PMID:26369692

  9. Uniform excitations in magnetic nanoparticles

    DEFF Research Database (Denmark)

    Mørup, Steen; Frandsen, Cathrine; Hansen, Mikkel Fougt


    We present a short review of the magnetic excitations in nanoparticles below the superparamagnetic blocking temperature. In this temperature regime, the magnetic dynamics in nanoparticles is dominated by uniform excitations, and this leads to a linear temperature dependence of the magnetization...... and the magnetic hyperfine field, in contrast to the Bloch T3/2 law in bulk materials. The temperature dependence of the average magnetization is conveniently studied by Mössbauer spectroscopy. The energy of the uniform excitations of magnetic nanoparticles can be studied by inelastic neutron scattering....

  10. Sublogarithmic uniform Boolean proof nets

    CERN Document Server

    Aubert, Clément


    Using a proofs-as-programs correspondence, Terui was able to compare two models of parallel computation: Boolean circuits and proof nets for multiplicative linear logic. Mogbil et. al. gave a logspace translation allowing us to compare their computational power as uniform complexity classes. This paper presents a novel translation in AC0 and focuses on a simpler restricted notion of uniform Boolean proof nets. We can then encode constant-depth circuits and compare complexity classes below logspace, which were out of reach with the previous translations.

  11. Effects of Magnetic Field on Biological Cells and Applications (United States)

    Chen, Ching-Jen


    While there has been extensive research performed in the physics of magnetic fields and the physics and chemistry in life sciences, independent of each other, there has been a paucity of scientific research and development investigating the possible applications of magnetic fields in life sciences. The focus of this presentation is to present the stimulation mechanism by which magnetic fields affect (a) yeast cells (b) plant cells and (c) mammalian normal and cancer cells. Recently we have found that the Saccharomyces Cerevsa yeast growth increases by about 30to a 1 tesla field and the production of CO2 increases by about 30of yeast metabolism may be due to an increase in intercellular interaction and protein channel alignment, the introduction of an alteration in the DNA from the magnetic field exposure or a combination of these mechanisms. We also have found that the application of high magnetic fields (1 tesla and above) can have marked effects on the germination and growth of plants, especially corn, beans and peas. This finding has opened up the possibility of technology developments in botanical growth systems to accelerate seed germination and crop harvesting. Most recently we have investigated the application of high magnetic fields on leukemia, CaCoII and HEP G2 cancer cell lines. We found that when leukemia are exposed to a 12 tesla field for 2 hours has an increase in cell death by about 30that were not exposed to the magnetic field. Viability of CaCoII cells sandwiched between permanent magnets of maximum strength of 1.2 tesla was measured. A decrease in viable cells by 33unexposed cells. HSP 70 was measured for HEPG2 cells that were exposed to permanent magnetic field of 1.2 tesla for 40 minutes and for unexposed cells. It was found that the exposed cells produce 19 times more HSP70 compared to unexposed cells. Our results together with other investigators report suggest a strong evidence of a reduction in the cell growth rate for cancer cells when

  12. Radiation effects on the flow of Powell-Eyring fluid past an unsteady inclined stretching sheet with non-uniform heat source/sink.

    Directory of Open Access Journals (Sweden)

    Tasawar Hayat

    Full Text Available This study investigates the unsteady flow of Powell-Eyring fluid past an inclined stretching sheet. Unsteadiness in the flow is due to the time-dependence of the stretching velocity and wall temperature. Mathematical analysis is performed in the presence of thermal radiation and non-uniform heat source/sink. The relevant boundary layer equations are reduced into self-similar forms by suitable transformations. The analytic solutions are constructed in a series form by homotopy analysis method (HAM. The convergence interval of the auxiliary parameter is obtained. Graphical results displaying the influence of interesting parameters are given. Numerical values of skin friction coefficient and local Nusselt number are computed and analyzed.

  13. Allee effects in tritrophic food chains: some insights in pest biological control. (United States)

    Costa, Michel Iskin da S; Dos Anjos, Lucas


    Release of natural enemies to control pest populations is a common strategy in biological control. However, its effectiveness is supposed to be impaired, among other factors, by Allee effects in the biological control agent and by the fact that introduced pest natural enemies interact with some native species of the ecosystem. In this work, we devise a tritrophic food chain model where the assumptions previously raised are proved correct when a hyperpredator attacks the introduced pest natural enemy by a functional response type 2 or 3. Moreover, success of pest control is shown to be related to the release of large amounts (i.e., inundative releases) of natural enemies.

  14. Study of complex matrix effect on solid phase microextraction for biological sample analysis. (United States)

    Jiang, Ruifen; Xu, Jianqiao; Zhu, Fang; Luan, Tiangang; Zeng, Feng; Shen, Yong; Ouyang, Gangfeng


    Solid phase microextraction (SPME) has become a useful tool for in vivo monitoring the behavior of environmental organic pollutants in biological species due to its simplicity, relatively non-invasive, and cost-effective manner. However, the complex matrices in biological samples could significantly influence the extraction kinetic, and bias the quantification result. In this study, we investigated the effect of complex matrix on the extraction kinetic of SPME for biological sample analysis. Two sample matrices, phosphate-buffered saline (PBS) with bovine serum albumin (BSA) and agarose gel with BSA were used to simulate the biological fluid and tissue. Results showed that the addition of BSA significantly enhanced the mass transfer of organic compounds onto SPME fiber in both PBS buffer and gel sample. Enhancement factors ranging from 1.3 to 27, and 2.0 to 80 were found for all selected polyaromatic hydrocarbons (PAHs) in PBS buffer and agarose gel with BSA concentration of 0.1-5%, respectively. Then, an improved theoretical model was applied to quantify the observed enhancement effect, and the result showed that the predicted sampling time constant agreed well with the experimental one in complex matrix. Furthermore, a simplified equation was proposed for the real biological sample analysis.

  15. Nonlinear effects of the finite amplitude ultrasound wave in biological tissues

    Institute of Scientific and Technical Information of China (English)


    Nonlinear effects will occur during the transmission of the finite amplitude wave in biological tissues.The theoretical prediction and experimental demonstration of the nonlinear effects on the propagation of the finite amplitude wave at the range of biomedical ultrasound frequency and intensity are studied.Results show that the efficiency factor and effective propagation distance will decrease while the attenuation coefficient increases due to the existence of nonlinear effects.The experimental results coincided quite well with the theory.This shows that the effective propagation distance and efficiency factor can be used to describe quantitatively the influence of nonlinear effects on the propagation of the finite amplitude sound wave in biological tissues.

  16. ICBEN review of research on the biological effects of noise 2011-2014. (United States)

    Basner, Mathias; Brink, Mark; Bristow, Abigail; de Kluizenaar, Yvonne; Finegold, Lawrence; Hong, Jiyoung; Janssen, Sabine A; Klaeboe, Ronny; Leroux, Tony; Liebl, Andreas; Matsui, Toshihito; Schwela, Dieter; Sliwinska-Kowalska, Mariola; Sörqvist, Patrik


    The mandate of the International Commission on Biological Effects of Noise (ICBEN) is to promote a high level of scientific research concerning all aspects of noise-induced effects on human beings and animals. In this review, ICBEN team chairs and co-chairs summarize relevant findings, publications, developments, and policies related to the biological effects of noise, with a focus on the period 2011-2014 and for the following topics: Noise-induced hearing loss; nonauditory effects of noise; effects of noise on performance and behavior; effects of noise on sleep; community response to noise; and interactions with other agents and contextual factors. Occupational settings and transport have been identified as the most prominent sources of noise that affect health. These reviews demonstrate that noise is a prevalent and often underestimated threat for both auditory and nonauditory health and that strategies for the prevention of noise and its associated negative health consequences are needed to promote public health.

  17. Uniform approximation by (quantum) polynomials

    NARCIS (Netherlands)

    Drucker, A.; de Wolf, R.


    We show that quantum algorithms can be used to re-prove a classical theorem in approximation theory, Jackson's Theorem, which gives a nearly-optimal quantitative version of Weierstrass's Theorem on uniform approximation of continuous functions by polynomials. We provide two proofs, based respectivel

  18. Uniformer på arbejde

    DEFF Research Database (Denmark)

    Leilund, Helle

    Afhandlingen , Uniformer på arbejde - nutidige praksisser omkring ensartet arbejdstøj , har afsæt i det kulturhistoriske museums arbejde med ’ dragt ’ . På trods af at ensart et eller uniformt arbejdstøj er et velkendt dagligdags fænomen, som bruges af medarbejdere på mange nutidige arbejdspladser...

  19. Uniform Slavic Transliteration Alphabet (USTA). (United States)

    Dekleva, Borut

    The Uniform Slavic Transliteration Alphabet (USTA) was designed primarily with the following objectives: to aid librarians (catalogers and bibliographers), information scientists, transliterators, and editors of bibliographic works of the many Slavic tongues; and to serve as original research for the further development of a machine-readable…

  20. School Uniforms: Guidelines for Principals. (United States)

    Essex, Nathan L.


    Principals desiring to develop a school-uniform policy should involve parents, teachers, community leaders, and student representatives; beware restrictions on religious and political expression; provide flexibility and assistance for low-income families; implement a pilot program; align the policy with school-safety issues; and consider legal…

  1. Waist circumference as a mediator of biological maturation effect on the motor coordination in children (United States)

    Luz, Leonardo G.O.; Seabra, André; Padez, Cristina; Duarte, João P.; Rebelo-Gonçalves, Ricardo; Valente-dos-Santos, João; Luz, Tatiana D.D.; Carmo, Bruno C.M.; Coelho-e-Silva, Manuel


    Abstract Objective: The present study aimed to: 1) examine the association of biological maturation effect on performance at a motor coordination battery and 2) to assess whether the association between biological maturation and scores obtained in motor coordination tests is mediated by some anthropometric measurement. Methods: The convenience sample consisted of 73 male children aged 8 years old. Anthropometric data considered the height, body mass, sitting height, waist circumference, body mass index, fat mass and fat-free mass estimates. Biological maturation was assessed by the percentage of the predicted mature stature. Motor coordination was tested by the Körperkoordinationstest für Kinder. A partial correlation between anthropometric measurements, z-score of maturation and the motor coordination tests were performed, controlling for chronological age. Finally, causal mediation analysis was performed. Results: Height, body mass, waist circumference and fat mass showed a slight to moderate inverse correlation with motor coordination. Biological maturation was significantly associated with the balance test with backward walking (r=-0.34). Total mediation of the waist circumference was identified in the association between biological maturation and balance test with backward walking (77%). Conclusions: We identified an association between biological maturation and KTK test performance in male children and also verified that there is mediation of waist circumference. It is recommended that studies be carried out with female individuals and at other age ranges. PMID:26972616

  2. Effective identification of conserved pathways in biological networks using hidden Markov models.

    Directory of Open Access Journals (Sweden)

    Xiaoning Qian

    Full Text Available BACKGROUND: The advent of various high-throughput experimental techniques for measuring molecular interactions has enabled the systematic study of biological interactions on a global scale. Since biological processes are carried out by elaborate collaborations of numerous molecules that give rise to a complex network of molecular interactions, comparative analysis of these biological networks can bring important insights into the functional organization and regulatory mechanisms of biological systems. METHODOLOGY/PRINCIPAL FINDINGS: In this paper, we present an effective framework for identifying common interaction patterns in the biological networks of different organisms based on hidden Markov models (HMMs. Given two or more networks, our method efficiently finds the top matching paths in the respective networks, where the matching paths may contain a flexible number of consecutive insertions and deletions. CONCLUSIONS/SIGNIFICANCE: Based on several protein-protein interaction (PPI networks obtained from the Database of Interacting Proteins (DIP and other public databases, we demonstrate that our method is able to detect biologically significant pathways that are conserved across different organisms. Our algorithm has a polynomial complexity that grows linearly with the size of the aligned paths. This enables the search for very long paths with more than 10 nodes within a few minutes on a desktop computer. The software program that implements this algorithm is available upon request from the authors.

  3. Waist circumference as a mediator of biological maturation effect on the motor coordination in children

    Directory of Open Access Journals (Sweden)

    Leonardo G.O. Luz

    Full Text Available Abstract Objective: The present study aimed to: 1 examine the association of biological maturation effect on performance at a motor coordination battery and 2 to assess whether the association between biological maturation and scores obtained in motor coordination tests is mediated by some anthropometric measurement. Methods: The convenience sample consisted of 73 male children aged 8 years old. Anthropometric data considered the height, body mass, sitting height, waist circumference, body mass index, fat mass and fat-free mass estimates. Biological maturation was assessed by the percentage of the predicted mature stature. Motor coordination was tested by the Körperkoordinationstest für Kinder. A partial correlation between anthropometric measurements, z-score of maturation and the motor coordination tests were performed, controlling for chronological age. Finally, causal mediation analysis was performed. Results: Height, body mass, waist circumference and fat mass showed a slight to moderate inverse correlation with motor coordination. Biological maturation was significantly associated with the balance test with backward walking (r=-0.34. Total mediation of the waist circumference was identified in the association between biological maturation and balance test with backward walking (77%. Conclusions: We identified an association between biological maturation and KTK test performance in male children and also verified that there is mediation of waist circumference. It is recommended that studies be carried out with female individuals and at other age ranges.

  4. Neutron exposures in human cells: bystander effect and relative biological effectiveness.

    Directory of Open Access Journals (Sweden)

    Isheeta Seth

    Full Text Available Bystander effects have been observed repeatedly in mammalian cells following photon and alpha particle irradiation. However, few studies have been performed to investigate bystander effects arising from neutron irradiation. Here we asked whether neutrons also induce a bystander effect in two normal human lymphoblastoid cell lines. These cells were exposed to fast neutrons produced by targeting a near-monoenergetic 50.5 MeV proton beam at a Be target (17 MeV average neutron energy, and irradiated-cell conditioned media (ICCM was transferred to unirradiated cells. The cytokinesis-block micronucleus assay was used to quantify genetic damage in radiation-naïve cells exposed to ICCM from cultures that received 0 (control, 0.5, 1, 1.5, 2, 3 or 4 Gy neutrons. Cells grown in ICCM from irradiated cells showed no significant increase in the frequencies of micronuclei or nucleoplasmic bridges compared to cells grown in ICCM from sham irradiated cells for either cell line. However, the neutron beam has a photon dose-contamination of 5%, which may modulate a neutron-induced bystander effect. To determine whether these low doses of contaminating photons can induce a bystander effect, cells were irradiated with cobalt-60 at doses equivalent to the percent contamination for each neutron dose. No significant increase in the frequencies of micronuclei or bridges was observed at these doses of photons for either cell line when cultured in ICCM. As expected, high doses of photons induced a clear bystander effect in both cell lines for micronuclei and bridges (p<0.0001. These data indicate that neutrons do not induce a bystander effect in these cells. Finally, neutrons had a relative biological effectiveness of 2.0 ± 0.13 for micronuclei and 5.8 ± 2.9 for bridges compared to cobalt-60. These results may be relevant to radiation therapy with fast neutrons and for regulatory agencies setting standards for neutron radiation protection and safety.

  5. Effects of non-uniform suction flow on performance and pressure fluctuation in axial-flow pumps%入口非均匀流对轴流泵性能和压力脉动的影响

    Institute of Scientific and Technical Information of China (English)

    施卫东; 张光建; 张德胜; 吴苏青; 徐焰栋


    为研究入流条件对轴流泵的影响,建立了2种不同类型的非均匀速度入口分布,分别与均匀入流进行比较,得到非均匀入口边界条件对轴流泵影响的数值计算结果.将均匀入流下的数值模拟结果与试验值进行对比,验证了数值模型的可信性.在0.7Q~1.2Q工况范围内,对轴流泵的扬程、效率和径向力等曲线进行了对比分析,得出受入口速度非均匀性影响、轴流泵性能和径向载荷的变化结果.最后,在定常模拟的基础上,对设计工况下叶轮入口、叶轮出口和导叶出口处的压力脉动进行了监测,得到了2种非均匀入流条件对轴流泵3个典型位置处压力脉动的影响情况.结果表明,通过控制进口入流情况,可以使文中所研究的轴流泵的水动力性能好于轴向均匀入流时的水动力性能.%To study the effect of inflow conditions on an axial flow pump,two different types of non-u-niform inlet velocity distributions were established.By comparing with uniform inflow conditions,the effects of the non-uniform inflow conditions on pump performance,radial forces and pressure fluctua-tions were achieved by numerical simulations.Comparison of numerical simulation results and experi-mental values under uniform inflow verifies the accuracy of the numerical model.A comparative analy-sis of the effects on pump head,efficiency and radial force curves was performed under 0.7Q-1.2Q conditions.The variation of the axial flow pump performance and radial loads with the non-uniformity of the inlet velocity was obtained.Finally,based on the unsteady simulation,pressure fluctuations at impeller inlet,impeller outlet and guide vane exit at design condition were monitored,and the effects of two non-uniform inflows on pressure pulsations at three typical positions were achieved.The results show that by controlling the inflow situation,the hydrodynamic performance with non-uniform inflow is better

  6. Methods for studying and criteria for evaluating the biological effects of electric fields of industrial frequency

    Energy Technology Data Exchange (ETDEWEB)

    Savin, B.M.; Shandala, M.G.; Nikonova, K.V.; Morozov, Yu.A.


    Data are reviewed from a number of USSR research studies on the biological effects of electric power transmission lines of 1150 Kv and above. Effects on man, plants, animals, and terrestrial ecosystems are reported. Existing health standards in the USSR for the exposure of personnel working in electric fields are included. It is concluded that high-voltage electric fields have a harmful effect on man and his environment.

  7. Politicas de uniformes y codigos de vestuario (Uniforms and Dress-Code Policies). ERIC Digest. (United States)

    Lumsden, Linda

    This digest in Spanish examines schools' dress-code policies and discusses the legal considerations and research findings about the effects of such changes. Most revisions to dress codes involve the use of uniforms, typically as a way to curb school violence and create a positive learning environment. A recent survey of secondary school principals…

  8. General synthesis route to fabricate uniform upconversion luminescent gadolinium oxide hollow spheres. (United States)

    Jia, Guang; Zhang, Cuimiao; Ding, Shiwen; Wang, Liyong


    Uniform upconversion luminescent gadolinium oxide hollow spheres were successfully synthesized via a homogeneous precipitation method with carbon spheres as template followed by a calcination process. During the annealing process, the carbon spheres template can be effectively removed and the amorphous precursor has converted to crystalline Gd2O3, which can be confirmed by the XRD and TG-DSC analysis. SEM and TEM images indicate that the Gd2O3 hollow spheres with diameters of 300-400 nm are uniform in size and distribution. The rare earth activator ions Ln3+-doped Gd2O3 hollow spheres exhibit intense upconversion luminescence with different colors under 980 nm light excitation, which may find potential applications in the fields such as drug delivery or biological labeling. Moreover, the upconversion luminescent mechanisms of the hollow spherical phosphors were investigated in detail.

  9. Predator interference effects on biological control: The "paradox" of the generalist predator revisited (United States)

    Parshad, Rana D.; Bhowmick, Suman; Quansah, Emmanuel; Basheer, Aladeen; Upadhyay, Ranjit Kumar


    An interesting conundrum in biological control questions the efficiency of generalist predators as biological control agents. Theory suggests, generalist predators are poor agents for biological control, primarily due to mutual interference. However field evidence shows they are actually quite effective in regulating pest densities. In this work we provide a plausible answer to this paradox. We analyze a three species model, where a generalist top predator is introduced into an ecosystem as a biological control, to check the population of a middle predator, that in turn is depredating on a prey species. We show that the inclusion of predator interference alone, can cause the solution of the top predator equation to blow-up in finite time, while there is global existence in the no interference case. This result shows that interference could actually cause a population explosion of the top predator, enabling it to control the target species, thus corroborating recent field evidence. Our results might also partially explain the population explosion of certain species, introduced originally for biological control purposes, such as the cane toad (Bufo marinus) in Australia, which now functions as a generalist top predator. We also show both Turing instability and spatio-temporal chaos in the model. Lastly we investigate time delay effects.

  10. Biologically templated assembly of hybrid semiconducting nanomesh for high performance field effect transistors and sensors (United States)

    Byeon, Hye-Hyeon; Lee, Seung-Woo; Lee, Eun-Hee; Kim, Woong; Yi, Hyunjung


    Delicately assembled composites of semiconducting nanomaterials and biological materials provide an attractive interface for emerging applications, such as chemical/biological sensors, wearable health monitoring devices, and therapeutic agent releasing devices. The nanostructure of composites as a channel and a sensing material plays a critical role in the performance of field effect transistors (FETs). Therefore, it is highly desirable to prepare elaborate composite that can allow the fabrication of high performance FETs and also provide high sensitivity and selectivity in detecting specific chemical/biological targets. In this work, we demonstrate that high performance FETs can be fabricated with a hydrodynamically assembled composite, a semiconducting nanomesh, of semiconducting single-walled carbon nanotubes (S-SWNTs) and a genetically engineered M13 phage to show strong binding affinity toward SWNTs. The semiconducting nanomesh enables a high on/off ratio (~104) of FETs. We also show that the threshold voltage and the channel current of the nanomesh FETs are sensitive to the change of the M13 phage surface charge. This biological gate effect of the phage enables the detection of biologically important molecules such as dopamine and bisphenol A using nanomesh-based FETs. Our results provide a new insight for the preparation of composite material platform for highly controllable bio/electronics interfaces.

  11. Biologically templated assembly of hybrid semiconducting nanomesh for high performance field effect transistors and sensors (United States)

    Byeon, Hye-Hyeon; Lee, Seung-Woo; Lee, Eun-Hee; Kim, Woong; Yi, Hyunjung


    Delicately assembled composites of semiconducting nanomaterials and biological materials provide an attractive interface for emerging applications, such as chemical/biological sensors, wearable health monitoring devices, and therapeutic agent releasing devices. The nanostructure of composites as a channel and a sensing material plays a critical role in the performance of field effect transistors (FETs). Therefore, it is highly desirable to prepare elaborate composite that can allow the fabrication of high performance FETs and also provide high sensitivity and selectivity in detecting specific chemical/biological targets. In this work, we demonstrate that high performance FETs can be fabricated with a hydrodynamically assembled composite, a semiconducting nanomesh, of semiconducting single-walled carbon nanotubes (S-SWNTs) and a genetically engineered M13 phage to show strong binding affinity toward SWNTs. The semiconducting nanomesh enables a high on/off ratio (~104) of FETs. We also show that the threshold voltage and the channel current of the nanomesh FETs are sensitive to the change of the M13 phage surface charge. This biological gate effect of the phage enables the detection of biologically important molecules such as dopamine and bisphenol A using nanomesh-based FETs. Our results provide a new insight for the preparation of composite material platform for highly controllable bio/electronics interfaces. PMID:27762315

  12. Biologically effective doses of postoperative radiotherapy in the prevention of keloids. Dose-effect relationship

    Energy Technology Data Exchange (ETDEWEB)

    Kal, H.B.; Veen, R.E. [University Medical Center Utrecht (Netherlands). Dept. of Radiotherapy


    Purpose: To review the recurrence rates of keloids after surgical excision followed by radiotherapy, and to answer the question whether after normalization of the dose, a dose-effect relationship could be derived. Material and Methods: A literature search was performed to identify studies dealing with the efficacy of various irradiation regimes for the prevention of keloids after surgery. Biologically effective doses (BEDs) of the various irradiation regimens were calculated using the linear-quadratic concept. A distinction between recurrence rates of keloids in the face and neck region and those in other parts of the body was made. Results: 31 reports were identified with PubMed with the search terms keloids, surgery, radiation therapy, radiotherapy. 13 reports were excluded, because no link could be found between recurrence rate and dose, or if less than ten patients per dose group. The recurrence rate for surgery only was 50-80%. For BED values >10 Gy the recurrence rate decreased as a function of BED. For BED values >30 Gy the recurrence rate was <10%. For a given dose, the recurrence rates of keloids in the sites with high stretch tension were not significantly higher than in sites without stretch tension. Conclusion: The results of this study indicate that for effectively treating keloids postoperatively, a relatively high dose must be applied in a short overall treatment time. The optimal treatment probably is an irradiation scheme resulting in a BED value of at least 30 Gy. A BED value of 30 Gy can be obtained with, for instance, a single acute dose of 13 Gy, two fractions of 8 Gy two fractions of 8 Gy or three fractions of 6 Gy, or a single dose of 27 Gy at low dose rate. The radiation treatment should be administered within 2 days after surgery. (orig.)


    Directory of Open Access Journals (Sweden)

    I. PET


    Full Text Available The carrying out of uniform forage crops represents an important technological loop for all agricultural species. The uniformity of these crops is caused especially by seed germination capacity, respectively by plant emergence capacity, depending upon the climatic and technological conditions. With regards to the researches carried out in this direction, we present here the influence exerted by some biologically-active products, used through extra-root application during plant vegetation period, upon seeds submitted to germination. The observations performed on smooth brome seeds have led to the conclusion that the per cent of germinated seeds ranges from 82%, in the untreated control variant, to 87.67% in the variant treated with the product Stimupro.

  14. Effects of Developed Electronic Instructional Medium on Students' Achievement in Biology (United States)

    Chinna, Nsofor Caroline; Dada, Momoh Gabriel


    The study investigated the effects of developed electronic instructional medium (video DVD instructional package) on students' achievement in Biology. It was guided by two research questions and two hypotheses, using a quasi-experimental, pretest-postest control group design. The sample comprised of 180 senior secondary, year two students from six…

  15. Static magnetic fields: A summary of biological interactions, potential health effects, and exposure guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Tenforde, T.S.


    Interest in the mechanisms of interaction and the biological effects of static magnetic fields has increased significantly during the past two decades as a result of the growing number of applications of these fields in research, industry and medicine. A major stimulus for research on the bioeffects of static magnetic fields has been the effort to develop new technologies for energy production and storage that utilize intense magnetic fields (e.g., thermonuclear fusion reactors and superconducting magnet energy storage devices). Interest in the possible biological interactions and health effects of static magnetic fields has also been increased as a result of recent developments in magnetic levitation as a mode of public transportation. In addition, the rapid emergence of magnetic resonance imaging as a new clinical diagnostic procedure has, in recent years, provided a strong rationale for defining the possible biological effects of magnetic fields with high flux densities. In this review, the principal interaction mechanisms of static magnetic fields will be described, and a summary will be given of the present state of knowledge of the biological, environmental, and human health effects of these fields.

  16. Biological effects from electric fields associated with high voltage transmission lines

    Energy Technology Data Exchange (ETDEWEB)


    Efforts during the past year by the US Department of Energy and the Electric Power Research Institute-funded laboratories to investigate the biological effects from electric fields are described in resume form. Investigations generally have been summarized with objectives, accomplishments of the past year, and some indication of projected studies.

  17. The Effectiveness of a Virtual Field Trip (VFT) Module in Learning Biology (United States)

    Haris, Norbaizura; Osman, Kamisah


    Virtual Field Trip is a computer aided module of science developed to study the Colonisation and Succession in Mangrove Swamps, as an alternative to the real field trip in Form for Biology. This study is to identify the effectiveness of the Virtual Field Trip (VFT) module towards the level of achievement in the formative test for this topic. This…

  18. Effectiveness of Blended Cooperative Learning Environment in Biology Teaching: Classroom Community Sense, Academic Achievement and Satisfaction (United States)

    Yapici, I. Ümit


    The aim of this study was to examine the effect of Blended Cooperative Learning Environment (BCLE) in biology teaching on students' classroom community sense, their academic achievement and on their levels of satisfaction. In the study, quantitative and qualitative research methods were used together. The study was carried out with 30 students in…

  19. Biological assessment of effects of combined sewer overflows and storm water discharges.

    NARCIS (Netherlands)

    Lijklema, L.; Roijackers, R.M.M.; Cuppen, J.G.M.


    The biological effects of discharges from combined or separated sewer systems are difficult to assess or to predict due to variahilities in concentrations, environmental conditions, morphometry, susceptibility of organisms, seasonality and other factors. A general discussion of the problem results i

  20. Simulation of the radiation effects on biological objects; Simulation der Strahlenwirkung auf biologische Objekte

    Energy Technology Data Exchange (ETDEWEB)

    Bug, Marion; Nettelbeck, Heidi [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (Germany). Arbeitsgruppe ' Biologische Wirksamkeit Ionisierender Strahlung'


    The simulation of biological radiation effects by means of the electron transport in water and DNA and the cross sections for elastic scattering, electronic excitation, and ionization in electron collisions with tetrahydrofuran molecules is described, whereby the strand-breaking probabilities are determined. (HSI)

  1. Effects of organic versus conventional management on chemical and biological parameters in agricultural soils

    NARCIS (Netherlands)

    Diepeningen, van A.D.; Vos, de O.J.; Korthals, G.W.; Bruggen, van A.H.C.


    A comparative study of organic and conventional arable farming systems was conducted in The Netherlands to determine the effect of management practices on chemical and biological soil properties and soil health. Soils from thirteen accredited organic farms and conventionally managed neighboring farm

  2. Effectiveness of the Biology PTechLS Module in a Felda Science Centre (United States)

    Alias, Norlidah; DeWitt, Dorothy; Rahman, Mohd Nazri Abdul; Gelamdin, Rashidah Begum; Rauf, Rose Amnah Abd; Siraj, Saedah


    The PTechLS module combines learning styles with the use of technology to increase students' learning experience, especially in learning abstract concepts. The PTechLS module prototype was developed by Norlidah Alias (2010). The aim of this study is to evaluate the implementation effectiveness of the Biology PTechLS module in a Felda Learning…

  3. Why magnetic and electromagnetic effects in biology are irreproducible and contradictory? (United States)

    Buchachenko, Anatoly


    The main source of magnetic and electromagnetic effects in biological systems is now generally accepted and demonstrated in this paper to be radical pair mechanism which implies pairwise generation of radicals in biochemical reactions. This mechanism was convincingly established for enzymatic adenosine triphosphate (ATP) and desoxynucleic acid (DNA) synthesis by using catalyzing metal ions with magnetic nuclei ((25)Mg, (43)Ca, (67)Zn) and supported by magnetic field effects on these reactions. The mechanism, is shown to function in medicine as a medical remedy or technology (trans-cranial magnetic stimulation, nuclear magnetic control of the ATP synthesis in heart muscle, the killing of cancer cells by suppression of DNA synthesis). However, the majority of magnetic effects in biology remain to be irreproducible, contradictory, and enigmatic. Three sources of such a state are shown in this paper to be: the presence of paramagnetic metal ions as a component of enzymatic site or as an impurity in an uncontrollable amount; the property of the radical pair mechanism to function at a rather high concentration of catalyzing metal ions, when at least two ions enter into the catalytic site; and the kinetic restrictions, which imply compatibility of chemical and spin dynamics in radical pair. It is important to keep in mind these factors to properly understand and predict magnetic effects in magneto-biology and biology itself and deliberately use them in medicine.

  4. Risk of serious adverse effects of biological and targeted drugs in patients with rheumatoid arthritis

    DEFF Research Database (Denmark)

    Tarp, Simon; Eric Furst, Daniel; Boers, Maarten


    OBJECTIVES: To determine possible differences in serious adverse effects among the 10 currently approved biological and targeted synthetic DMARDs (b/ts-DMARDs) for RA. METHODS: Systematic review in bibliographic databases, trial registries and websites of regulatory agencies identified randomized...... differences in rates of SAEs. Our data suggest caution should be taken when deciding among available drugs. SYSTEMATIC REVIEW REGISTRATION NUMBER: PROSPERO CRD42014014842....

  5. Effect of temperature on the biology of Paracoccus marginatus Williams and Granara de Willink (Homoptera: Pseudococcidae). (United States)

    Abstract: Effect of temperature on the biology of Paracoccus marginatus was investigated. P. marginatus was able to develop and complete its life cycle at 18°, 20°, 25° and 30°C. At 15°, 34° and 35°C eggs hatched, but further development was arrested. Approximately 80 -90% of the eggs survived betw...

  6. Compensating effect of sap velocity for stand density leads to uniform hillslope-scale forest transpiration across a steep valley cross-section (United States)

    Renner, Maik; Hassler, Sibylle; Blume, Theresa; Weiler, Markus; Hildebrandt, Anke; Guderle, Marcus; Schymanski, Stan; Kleidon, Axel


    Roberts (1983) found that forest transpiration is relatively uniform across different climatic conditions and suggested that forest transpiration is a conservative process compensating for environmental heterogeneity. Here we test this hypothesis at a steep valley cross-section composed of European Beech in the Attert basin in Luxemburg. We use sapflow, soil moisture, biometric and meteorological data from 6 sites along a transect to estimate site scale transpiration rates. Despite opposing hillslope orientation, different slope angles and forest stand structures, we estimated relatively similar transpiration responses to atmospheric demand and seasonal transpiration totals. This similarity is related to a negative correlation between sap velocity and site-average sapwood area. At the south facing sites with an old, even-aged stand structure and closed canopy layer, we observe significantly lower sap velocities but similar stand-average transpiration rates compared to the north-facing sites with open canopy structure, tall dominant trees and dense understorey. This suggests that plant hydraulic co-ordination allows for flexible responses to environmental conditions leading to similar transpiration rates close to the water and energy limits despite the apparent heterogeneity in exposition, stand density and soil moisture. References Roberts, J. (1983). Forest transpiration: A conservative hydrological process? Journal of Hydrology 66, 133-141.

  7. Effects of red blood cell deformability on the non-uniform distribution of platelet-sized particles in blood flow through microchannels (United States)

    Sugihara-Seki, Masako; Sakamoto, Keisuke; Itano, Tomoaki; Seki, Junji


    In blood flow through microvessels, platelets are known to have enhanced concentrations near the vessel wall, which is the so-called "near-wall excess (NWE)". This phenomenon is considered to be caused by the interaction with red blood cells (RBCs); since RBCs have a tendency to approach the vessel centerline due to their highly deformability, they may push away less deformable platelets toward the near-wall region. In order to examine this proposition by in vitro experiments, we measured the distribution of platelet-sized particles mixed in intact RBC or hardened RBC suspensions flowing through microchannels of 50 μm x 50 μm cross-section. Hardened RBCs were prepared by immersing human RBCs in glutaraldehayde solution of 40 - 4000 ppm. Fluorescent observations were conducted with the use of a confocal laser scanning microscope system with a high-speed video camera. It was found that platelet-sized particles exhibited high concentrations near the channel wall, i.e., NWE, when they were mixed in intact RBC suspensions. By contrast, the particles mixed in hardened RBC suspensions showed weak NWE or uniform distribution over the channel cross-section, indicating that deformability of RBCs plays an essential role in the NWE phenomenon.

  8. Uniformity Analysis for Index of Retail Price

    Institute of Scientific and Technical Information of China (English)

    潘竞红; 曾庆洪; 刘梅英


    Using the Hodges-Ajne testing method, the uniformity of China retail price index was tested. The result, that population is submitting to uniform dist ribution, was obtained. The uniformity of CRPI indicates that the general price level is stable in the Ninth Five-Year Plan. Finally, the reasons causing the uniformity was analyzed.

  9. 46 CFR 310.11 - Cadet uniforms. (United States)


    ... for State, Territorial or Regional Maritime Academies and Colleges § 310.11 Cadet uniforms. Cadet uniforms shall be supplied at the school in accordance with the uniform regulations of the School. Those... 46 Shipping 8 2010-10-01 2010-10-01 false Cadet uniforms. 310.11 Section 310.11 Shipping...


    Energy Technology Data Exchange (ETDEWEB)

    Authors, Various


    Planning a rational energy future requires anticipating the environmental consequences of various technologies. This is difficult to do with precision as the effects of pollutants are often determined by interactions between and among complex physical (abiotic) and biological (biotic) systems. A given pollutant may affect human beings through direct exposure or indirectly through inducing changes to biological systems which humans need to utilize. The concentration of a toxin in the food chain or the destruction of organisms necessary for the maintenance of high quality water are examples of indirect effects. Pollutants can be transformed and/or degraded as they establish residence in various components of an ecosystem. Anticipation and amelioration of pollutant effects involves the integration of a vast range of data. This data includes: (1) physical and chemical characterization cf the pollutant as it enters the environment; (2) determining effects on the various components (biotic and abiotic) within the context of the functioning ecosystem of interest; (3) transformation in movements and/or degradation of the pollutant within that ecosystem and within specific organisms and physical components; and (4) determining a detailed biochemical and biological picture of the interactions of pollutants with particular organisms and/or their cellular components judged salient for various processes. The major programs described below are designed to answer parts of the above fundamental questions relevant to pollutants generated by energy related technologies. Their emphasis is on anticipating consequences to the biological components of various ecosystems. The work ranges from studies involving parts of a single cell (the membranes) to studies involving the whole ecosystem (in the pelagic zone of a lake). The programs take advantage of expertise and technical abilities present at LBL. Two small exploratory projects which were of brief duration and not related to


    Institute of Scientific and Technical Information of China (English)


    Objective To understand whether arsenic trioxide (As2O3)-induced biological effects are associated with degradation of PML proteins. Methods Acute promyelocytic leukemia (APL) cell line NB4, acute T-lymphocytic leukemia cell line Jurkat, acute myeloid leukemia cell line U937, and chronic myelocytic leukemia blast crisis cell line K562 were used as in vitro models. In different cell lines, the As2O3-induced bio- logical effects were determined by cell growth, cell viability, cell morphology, and flow cytometry assay on sub- G1 cell content. The alteration of PML proteins was analyzed by immunofluorescence. Results In terms of growth inhibition and apoptosis induction, 1.0μmol/L As2O3 had different effects on different cell lines. However, degradation of PML proteins occurred in all the cell lines with As2O3 treatment. Conclusion As2O3-induced biological effects may be independent of PML protein degradation.

  12. Information on biological health effects of ionizing radiation and radionuclides: the rule of a web site

    Energy Technology Data Exchange (ETDEWEB)

    Comte, A.; Gaillard-Lecanu, E.; Flury-Herard, A. [CEA Fontenay aux Roses, 92 (France); Ourly, F. [CEA Saclay, 91 - Gif sur Yvette (France); Hemidy, P.; Lallemand, J. [Electricite de France (EDF), Service de Radioprotection, 75 - Paris (France)


    The purpose of this project is to provide a source of information on biological and health effects of radionuclides and ionizing radiation in an easy to use format. Reported work is made up of two distinct parts: data sheets for selected radionuclides and a web file. Data sheets: Specific radiation data sheets provide an overview of the properties, the environmental behaviour, the different pathways of human exposure and the biological and health consequences of selected radionuclides. Radionuclides that have been selected are those commonly dealt with in nuclear industry (and in other areas such as medicine) and released to the environment or naturally occurring (plutonium, tritium, carbon 14). Data sheets corresponding to the different radionuclides are based on the main sources of scientific information in dosimetry, epidemiology, radiobiology and radiation protection. These data sheets are intended for radiation protection specialists and physicians. They include: main physical and chemical characteristics, main radiation protection data: dose coefficients (public, workers), dose limits sources, total released estimate (nuclear industry, atmospheric tests, main pathway of human exposure and biological behaviour, biological and health effects, medical supervision, treatment a list of the main references, appendix providing accurate information. Web file:{sub e}xt/fond.php This web file provides a source of information on biological and health effects of ionizing radiation and biological basic knowledge of radiation protection. Available for consultation via Internet, compiled information provides, in a same file, subjects as varied as biological mechanisms, ionizing radiations action, biological and health effects, risk assessment This file is mainly intended to assist in informing and training of non-specialist readership (students, teaching on radiation protection basic knowledge. This electronic document is divided in three

  13. Uniform-droplet spray forming

    Energy Technology Data Exchange (ETDEWEB)

    Blue, C.A.; Sikka, V.K. [Oak Ridge National Lab., TN (United States); Chun, Jung-Hoon [Massachusetts Institute of Technology, Cambridge, MA (United States); Ando, T. [Tufts Univ., Medford, MA (United States)


    The uniform-droplet process is a new method of liquid-metal atomization that results in single droplets that can be used to produce mono-size powders or sprayed-on to substrates to produce near-net shapes with tailored microstructure. The mono-sized powder-production capability of the uniform-droplet process also has the potential of permitting engineered powder blends to produce components of controlled porosity. Metal and alloy powders are commercially produced by at least three different methods: gas atomization, water atomization, and rotating disk. All three methods produce powders of a broad range in size with a very small yield of fine powders with single-sized droplets that can be used to produce mono-size powders or sprayed-on substrates to produce near-net shapes with tailored microstructures. The economical analysis has shown the process to have the potential of reducing capital cost by 50% and operating cost by 37.5% when applied to powder making. For the spray-forming process, a 25% savings is expected in both the capital and operating costs. The project is jointly carried out at Massachusetts Institute of Technology (MIT), Tuffs University, and Oak Ridge National Laboratory (ORNL). Preliminary interactions with both finished parts and powder producers have shown a strong interest in the uniform-droplet process. Systematic studies are being conducted to optimize the process parameters, understand the solidification of droplets and spray deposits, and develop a uniform-droplet-system (UDS) apparatus appropriate for processing engineering alloys.

  14. Status of study on biological and toxicological effects of nanoscale materials

    Institute of Scientific and Technical Information of China (English)

    WANG; Bing; FENG; Weiyue; ZHAO; Yuliang; XING; Gengmei; CH


    Because the physical and chemical properties of nanosized materials mostly differ from the existing microsized materials, their potential impacts on human health and the environment will be topics under the serious discussions in press and in a number of international scientific journals. We analyze and summarize the existing data of the experimental study on the biological activities and adverse effects of nanoscale materials/particles including single wall carbon nanotubes, multi wall carbon nanotubes, titanium oxide and iron powders. Though some biological behaviors of nanoscale materials observed cannot be understood on the basis of the current knowledge, as the existing data are mostly preliminary, it is too early to make some exclusive conclusions on biological activities (or the toxicity) of any of nanoscale materials. The experimental techniques, the current topics, and the future research directions for this new research field are also discussed.

  15. Biological effects of mercury pollution. (Latest citations from the NTIS bibliographic database). Published Search

    Energy Technology Data Exchange (ETDEWEB)



    The bibliography contains citations concerning biological and biochemical effects of mercury pollutants on humans, animals, and plants. References cover long-term and short-term experiments, biochemical reaction kinetics, pollution sources, and ecosystems. Mercury poisoning, metabolism, and related diseases are described. Carcinogenicity testing, health risk and assessment, and the effects on food chains are examined. (Contains 50-250 citations and includes a subject term index and title list.) (Copyright NERAC, Inc. 1995)

  16. Biological effects of low-level exposures: a perspective from U.S. EPA scientists.


    Davis, J M; Farland, W H


    Biological effects of low-level exposures (BELLE) may be very important in characterizing the potential health risks of environmental pollutants. Before some features of BELLE, such as effects that may be modulated by adaptive or defense mechanisms, can be taken into greater consideration in U.S. Environmental Protection Agency risk assessments, however adequate information on a toxicant's mode of action and answers to other questions are needed.

  17. The role of cell hydration in realization of biological effects of non-ionizing radiation (NIR). (United States)

    Ayrapetyan, Sinerik


    The weak knowledge on the nature of cellular and molecular mechanisms of biological effects of NIR such as static magnetic field, infrasound frequency of mechanical vibration, extremely low frequency of electromagnetic fields and microwave serves as a main barrier for adequate dosimetry from the point of Public Health. The difficulty lies in the fact that the biological effects of NIR depend not only on their thermodynamic characteristics but also on their frequency and intensity "windows", chemical and physical composition of the surrounding medium, as well as on the initial metabolic state of the organism. Therefore, only biomarker can be used for adequate estimation of biological effect of NIR on organisms. Because of the absence of such biomarker(s), organizations having the mission to monitor hazardous effects of NIR traditionally base their instruction on thermodynamic characteristics of NIR. Based on the high sensitivity to NIR of both aqua medium structure and cell hydration, it is suggested that cell bathing medium is one of the primary targets and cell hydration is a biomarker for NIR effects on cells and organisms. The purpose of this article is to present a short review of literature and our own experimental data on the effects of NIR on plants' seeds germination, microbe growth and development, snail neurons and heart muscle, rat's brain and heart tissues.

  18. Is ground cover vegetation an effective biological control enhancement strategy against olive pests?

    Directory of Open Access Journals (Sweden)

    Daniel Paredes

    Full Text Available Ground cover vegetation is often added or allowed to generate to promote conservation biological control, especially in perennial crops. Nevertheless, there is inconsistent evidence of its effectiveness, with studies reporting positive, nil or negative effects on pest control. This might arise from differences between studies at the local scale (e.g. orchard management and land use history, the landscape context (e.g. presence of patches of natural or semi-natural vegetation near the focal orchard, or regional factors, particularly climate in the year of the study. Here we present the findings from a long-term regional monitoring program conducted on four pest species (Bactrocera oleae, Prays oleae, Euphyllura olivina, Saissetia oleae in 2,528 olive groves in Andalusia (Spain from 2006 to 2012. Generalized linear mixed effect models were used to analyze the effect of ground cover on different response variables related to pest abundance, while accounting for variability at the local, landscape and regional scales. There were small and inconsistent effects of ground cover on the abundance of pests whilst local, landscape and regional variability explained a large proportion of the variability in pest response variables. This highlights the importance of local and landscape-related variables in biological control and the potential effects that might emerge from their interaction with practices, such as groundcover vegetation, implemented to promote natural enemy activity. The study points to perennial vegetation close to the focal crop as a promising alternative strategy for conservation biological control that should receive more attention.

  19. Is ground cover vegetation an effective biological control enhancement strategy against olive pests? (United States)

    Paredes, Daniel; Cayuela, Luis; Gurr, Geoff M; Campos, Mercedes


    Ground cover vegetation is often added or allowed to generate to promote conservation biological control, especially in perennial crops. Nevertheless, there is inconsistent evidence of its effectiveness, with studies reporting positive, nil or negative effects on pest control. This might arise from differences between studies at the local scale (e.g. orchard management and land use history), the landscape context (e.g. presence of patches of natural or semi-natural vegetation near the focal orchard), or regional factors, particularly climate in the year of the study. Here we present the findings from a long-term regional monitoring program conducted on four pest species (Bactrocera oleae, Prays oleae, Euphyllura olivina, Saissetia oleae) in 2,528 olive groves in Andalusia (Spain) from 2006 to 2012. Generalized linear mixed effect models were used to analyze the effect of ground cover on different response variables related to pest abundance, while accounting for variability at the local, landscape and regional scales. There were small and inconsistent effects of ground cover on the abundance of pests whilst local, landscape and regional variability explained a large proportion of the variability in pest response variables. This highlights the importance of local and landscape-related variables in biological control and the potential effects that might emerge from their interaction with practices, such as groundcover vegetation, implemented to promote natural enemy activity. The study points to perennial vegetation close to the focal crop as a promising alternative strategy for conservation biological control that should receive more attention.

  20. Biological effects of atmospheric particles on human bronchial epithelial cells. Comparison with diesel exhaust particles. (United States)

    Baulig, Augustin; Sourdeval, Matthieu; Meyer, Martine; Marano, Francelyne; Baeza-Squiban, Armelle


    Epidemiological studies have associated the increase of respiratory disorders with high levels of ambient particulate matter (PM) levels although the underlying biological mechanisms are unclear. PM are a complex mixture of particles with different origins but in urban areas, they mainly contain soots from transport like Diesel exhaust particles (DEP). In order to determine whether PM biological effects can be explained by the presence of DEP, the effects of urban PM, DEP and carbon black particles (CB) were compared on a human bronchial epithelial cell line (16-HBE14o-). Two types of PM were used : reference material (RPM) and PM with an aerodynamic diameter particles. However, DEP and to a lower extent PM inhibited cell proliferation, induced the release of a pro-inflammatory cytokine, GM-CSF, and generated a pro-oxidant state as shown by the increased intracellular peroxides production. By contrast, CB never induced such effects. Nevertheless CB are more endocytosed than DEP whereas PM are the less endocytosed particles. In conclusion, PM induced to a lower extent the same biological effects than DEP in 16-HBE cells suggesting that particle characteristics should be thoroughly considered in order to clearly correlate adverse effects of PM to their composition and to clarify the role of DEP in PM effects.

  1. Reduction of the effect of non-uniform backscatter from an E-type support arm of a Varian a-Si EPID used for dosimetry. (United States)

    Rowshanfarzad, Pejman; Sabet, Mahsheed; O'Connor, Daryl J; Greer, Peter B


    Backscatter from the metallic components in the support arm is one of the sources of inaccuracy in dosimetry with Varian amorphous silicon electronic portal imaging devices (a-Si EPIDs). In this study, the non-uniform arm backscatter is blocked by adding lead sheets between the EPID and an E-type support arm. By comparing the EPID responses on and off the arm, with and without lead and considering the extra weight on the imager, 2 mm of lead was determined as the optimum thickness for both 6 and 18 MV beam energies. The arm backscatter at the central axis with the 2 mm lead in place decreased to 0.1% and 0.2% for the largest field size of 30 × 30 cm(2) using 6 and 18 MV beams, from 2.3% and 1.3% without lead. Changes in the source-to-detector distance (SDD) did not affect the backscatter component more than 1%. The symmetry of the in-plane profiles improved for all field sizes for both beam energies. The addition of lead decreased the contrast-to-noise ratio and resolution by 1.3% and 0.84% for images taken in 6 MV and by 0.5% and 0.38% for those in 18 MV beams. The displacement of the EPID central pixel was measured during a 360° gantry rotation with and without lead which was 1 pixel different. While the backscatter reduces with increasing lead thickness, a 2 mm lead sheet seems sufficient for acceptable dosimetry results without any major degradation to the routine performance of the imager. No increase in patient skin dose was detected.

  2. Comparison of MCNP4B and WIMS-AECL calculations of coolant-void-reactivity effects for uniform lattices of CANDU fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kozier, K.S


    This paper compares the results of coolant-void reactivity (CVR) reactor-physics calculations performed using the Monte Carlo N-particle transport code, MCNP version 4B, with those obtained using Atomic Energy of Canada Limited's (AECL's) latest version of the Winfrith improved multigroup scheme (WIMS) code, WIMS-AECL version 2-5c. Cross sections derived from the evaluated nuclear data file version B-VI (ENDF/B-VI) are used for both the WIMS-AECL and MCNP4B calculations. The comparison is made for uniform lattices at room temperature containing either fresh natural uranium or mixed oxide (MOX) 37-element CANDU fuel. The MOX fuel composition corresponds roughly to that of irradiated CANDU fuel at a burnup of about 4500 MWd/tU. The level of agreement between the CVR predictions of WIMS-AECL and MCNP4B is studied as a function of lattice buckling (a measure of the curvature of the neutron-flux distribution) over the range from 0.0 to 4.1 m{sup -2} . For the cases studied, it is found that the absolute k values calculated by WIMS-AECL are higher than those of MCNP4B by several mk (1 mk is a change of 0.001 in k), amounts that depend on the fuel type being modelled and the particular cross-section data used. However, the agreement between WIMS-AECL and MCNP4B is much better for the CVR (i.e., the {delta}k on coolant voiding), and is relatively insensitive to the fuel type. (author)

  3. Comparison of MCNP4B and WIMS-AECL calculations of coolant-void-reactivity effects for uniform lattices of CANDU fuel

    Energy Technology Data Exchange (ETDEWEB)

    Kozier, K.S. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada)


    This paper compares the results of coolant-void reactivity (CVR) reactor-physics calculations performed using the Monte Carlo N-particle transport code, MCNP version 4B, with those obtained using Atomic Energy of Canada Limited's (AECL's) latest version of the Winfrith improved multigroup scheme (WIMS) code, WIMS-AECL version 2-5c. Cross sections derived from the evaluated nuclear data file version B-VT (ENDF/B-VI) are used for both the WIMS-AECL and MCNP4B calculations. The comparison is made for uniform lattices at room temperature containing either fresh natural uranium or mixed oxide (MOX) 37-element CANDU fuel. The MOX fuel composition corresponds roughly to that of irradiated CANDU fuel at a burnup of about 4500 MWd/tU. The level of agreement between the CVR predictions of WIMS-AECL and MCNP4B is studied as a function of lattice buckling (a measure of the curvature of the neutron-flux distribution) over the range from 0.0 to 4.1 m{sup -2}. For the cases studied, it is found that the absolute keff values calculated by WIMS-AECL are higher than those of MCNP4B by several mk (1 mk is a change of 0.001 in keff), amounts that depend on the fuel type being modelled and the particular cross-section data used. However, the agreement between WIMS-AECL and MCNP4B is much better for the CVR (i.e., the {delta}keff on coolant voiding), and is relatively insensitive to the fuel type. (author)

  4. Benthic biological effects of seasonal hypoxia in a eutrophic estuary predate rapid coastal development (United States)

    Bishop, Melanie J.; Powers, Sean P.; Porter, Hugh J.; Peterson, Charles H.


    Nutrient and organic loading associated with escalating human activities increases biological oxygen demand from microbial decomposition. In the Neuse River estuary, North Carolina, recurrent nuisance algal blooms, bottom-water hypoxic events, and fish kills during summers of the 1990s suggest that uncapped nutrient loading may have increased the frequency, duration, and/or spatial scope of important biological effects of hypoxia during summer, when persistent water column stratification can occur and microbial metabolism is greatest. We test the hypothesis that the severity of benthic biological effects of hypoxia in this estuary has increased over a 30-year period of dramatic human population growth in eastern North Carolina by comparing survival over summer of the benthic bivalve Macoma spp. between historical (1968-1970) and recent (1997-1998) years. Macoma is a demonstrated indicator of oxygen availability, the benthic biomass dominant in the Neuse and other temperate estuaries and the major prey link to higher trophic levels. All three historical summers exhibited patterns of collapse in Macoma populations indistinguishable from the recent summer of severe hypoxia (1997) but distinct from the modest changes documented during the mildly hypoxic summer of 1998. The only Macoma to survive any severely hypoxic summer were those in shallows where oxygen could be renewed by surface mixing. Thus, the biological effects of hypoxia observed in the Neuse River estuary in the late 1990s appear no more severe than 30 years before. Historic rates of organic loading to the Neuse River estuary may have been sufficient to induce widespread and intense hypoxia beneath the surface mixed layer, implying that even if algal blooms are diminished through nutrient reductions, the severity of biological effects of bottom-water hypoxia may not change detectably.

  5. Distinct biological effects of different nanoparticles commonly used in cosmetics and medicine coatings

    Directory of Open Access Journals (Sweden)

    Yu Julia X


    Full Text Available Abstract Background Metal oxides in nanoparticle form such as zinc oxide and titanium dioxide now appear on the ingredient lists of household products as common and diverse as cosmetics, sunscreens, toothpaste, and medicine. Previous studies of zinc oxide and titanium dioxide in non-nanoparticle format using animals have found few adverse effects. This has led the FDA to classify zinc oxide as GRAS (generally recognized as safe for use as a food additive. However, there is no regulation specific for the use of these chemicals in nanoparticle format. Recent studies, however, have begun to raise concerns over the pervasive use of these compounds in nanoparticle forms. Unfortunately, there is a lack of easily-adaptable screening methods that would allow for the detection of their biological effects. Results We adapted two image-based assays, a fluorescence resonance energy transfer-based caspase activation assay and a green fluorescent protein coupled-LC3 assay, to test for the biological effects of different nanoparticles in a high-throughput format. We show that zinc oxide nanoparticles are cytotoxic. We also show that titanium dioxide nanoparticles are highly effective in inducing autophagy, a cellular disposal mechanism that is often activated when the cell is under stress. Conclusion We suggest that these image-based assays provide a method of screening for the biological effects of similar compounds that is both efficient and sensitive as well as do not involve the use of animals.

  6. In vitro cultured cells as probes for space radiation effects on biological systems

    Energy Technology Data Exchange (ETDEWEB)

    Meli, A.; Perrella, G.; Curcio, F.; Ambesi-Impiombato, F.S. [Dipartimento di Patologia e Medicina Sperimentale e Clinica, Universita di Udine, P.le S. Maria della Misericordia, 33100 Udine (Italy)


    Near future scenarios of long-term and far-reaching manned space missions, require more extensive knowledge of all possible biological consequences of space radiation, particularly in humans, on both a long-term and a short-term basis. In vitro cultured cells have significantly contributed to the tremendous advancement of biomedical research. It is therefore to be expected that simple biological systems such as cultured cells, will contribute to space biomedical sciences. Space represents a novel environment, to which life has not been previously exposed. Both microgravity and space radiation are the two relevant components of such an environment, but biological adaptive mechanisms and efficient countermeasures can significantly minimize microgravity effects. On the other hand, it is felt that space radiation risks may be more relevant and that defensive strategies can only stem from our deeper knowledge of biological effects and of cellular repair mechanisms. Cultured cells may play a key role in such studies. Particularly, thyroid cells may be relevant because of the exquisite sensitivity of the thyroid gland to radiation. In addition, a clone of differentiated, normal thyroid follicular cells (FRTL5 cells) is available in culture, which is well characterized and particularly fit for space research.

  7. Biological Effect of Ultraviolet Photocatalysis on Nanoscale Titanium with a Focus on Physicochemical Mechanism. (United States)

    Wu, Jingyi; Zhou, Lei; Ding, Xianglong; Gao, Yan; Liu, Xiangning


    Physicochemical properties, regulated by various surface modifications, influence the biological performance of materials. The interaction between surface charge and biomolecules is key to understanding the mechanism of surface-tissue integration. The objective of this study was to evaluate the biological response to a nanoscale titanium surface after ultraviolet (UVC, λ = 250 ± 20 nm) irradiation and to analyze the effects via a physicochemical mechanism. The surface characteristics were evaluated by field-emission scanning electron microscopy, X-ray photoelectron spectroscopy, surface profilometry, and contact angle assay. In addition, we applied the zeta-potential, a direct method to measure the electrostatic charge on UV-treated and UV-untreated titanium nanotube surfaces. The effect of the Ti surface after UV treatment on the biological process was determined by analyzing bovine serum albumin (BSA) adsorption and osteoblast-like MG-63 early adhesion, morphology, cytoskeletal arrangement, proliferation, and focal adhesion. Compared to an anodized titanium nanotube coating, UV irradiation altered the contact angles on the control surface from 51.5° to 6.2° without changing the surface topography or roughness. Furthermore, titanium nanotubes after UV treatment showed a significant reduction in the content of acidic hydroxyl groups and held less negative charge than the anodized coating. With regard to the biological response, along with an enhanced capability to adsorb BSA, osteoblasts exhibited higher colonization and viability on the UV-treated material. The results suggest that UV treatment enhances the biocompatibility by reducing the electrostatic repulsion between biomaterials and biomolecules.

  8. Effectiveness of biological surrogates for predicting patterns of marine biodiversity: a global meta-analysis.

    Directory of Open Access Journals (Sweden)

    Camille Mellin

    Full Text Available The use of biological surrogates as proxies for biodiversity patterns is gaining popularity, particularly in marine systems where field surveys can be expensive and species richness high. Yet, uncertainty regarding their applicability remains because of inconsistency of definitions, a lack of standard methods for estimating effectiveness, and variable spatial scales considered. We present a Bayesian meta-analysis of the effectiveness of biological surrogates in marine ecosystems. Surrogate effectiveness was defined both as the proportion of surrogacy tests where predictions based on surrogates were better than random (i.e., low probability of making a Type I error; P and as the predictability of targets using surrogates (R(2. A total of 264 published surrogacy tests combined with prior probabilities elicited from eight international experts demonstrated that the habitat, spatial scale, type of surrogate and statistical method used all influenced surrogate effectiveness, at least according to either P or R(2. The type of surrogate used (higher-taxa, cross-taxa or subset taxa was the best predictor of P, with the higher-taxa surrogates outperforming all others. The marine habitat was the best predictor of R(2, with particularly low predictability in tropical reefs. Surrogate effectiveness was greatest for higher-taxa surrogates at a <10-km spatial scale, in low-complexity marine habitats such as soft bottoms, and using multivariate-based methods. Comparisons with terrestrial studies in terms of the methods used to study surrogates revealed that marine applications still ignore some problems with several widely used statistical approaches to surrogacy. Our study provides a benchmark for the reliable use of biological surrogates in marine ecosystems, and highlights directions for future development of biological surrogates in predicting biodiversity.

  9. State-of-the-art exposure chamber for highly controlled and reproducible THz biological effects studies (United States)

    Cerna, Cesario Z.; Elam, David P.; Echchgadda, Ibtissam; Sloan, Mark A.; Wilmink, Gerald J.


    Terahertz (THz) imaging and sensing technologies are increasingly being used at international airports for security screening purposes and at major medical centers for cancer and burn diagnosis. The emergence of new THz applications has directly resulted in an increased interest regarding the biological effects associated with this frequency range. Knowledge of THz biological effects is also desired for the safe use of THz systems, identification of health hazards, and development of empirically-based safety standards. In this study, we developed a state-of-the-art exposure chamber that allowed for highly controlled and reproducible studies of THz biological effects. This innovative system incorporated an industry grade cell incubator system that permitted a highly controlled exposure environment, where temperatures could be maintained at 37 °C +/- 0.1 °C, carbon dioxide (CO2) levels at 5% +/- 0.1%, and relative humidity (RH) levels at 95% +/- 1%. To maximize the THz power transmitted to the cell culture region inside the humid incubator, a secondary custom micro-chamber was fabricated and incorporated into the system. This micro-chamber shields the THz beam from the incubator environment and could be nitrogen-purged to eliminate water absorption effects. Additionally, a microscope that allowed for real-time visualization of the live cells before, during, and after THz exposure was integrated into the exposure system.

  10. The cost-effectiveness of biologics for the treatment of rheumatoid arthritis: a systematic review.

    Directory of Open Access Journals (Sweden)

    Jaana T Joensuu

    Full Text Available Economic evaluations provide information to aid the optimal utilization of limited healthcare resources. Costs of biologics for Rheumatoid arthritis (RA are remarkably high, which makes these agents an important target for economic evaluations. This systematic review aims to identify existing studies examining the cost-effectiveness of biologics for RA, assess their quality and report their results systematically.A literature search covering Medline, Scopus, Cochrane library, ACP Journal club and Web of Science was performed in March 2013. The cost-utility analyses (CUAs of one or more available biological drugs for the treatment of RA in adults were included. Two independent investigators systematically collected information and assessed the quality of the studies. To enable the comparison of the results, all costs were converted to 2013 euro.Of the 4890 references found in the literature search, 41 CUAs were included in the current systematic review. While considering only direct costs, the incremental cost-effectiveness ratio (ICER of the tumor necrosis factor inhibitors (TNFi ranged from 39,000 to 1,273,000 €/quality adjusted life year (QALY gained in comparison to conventional disease-modifying antirheumatic drugs (cDMARDs in cDMARD naïve patients. Among patients with an insufficient response to cDMARDs, biologics were associated with ICERs ranging from 12,000 to 708,000 €/QALY. Rituximab was found to be the most cost-effective alternative compared to other biologics among the patients with an insufficient response to TNFi.When 35,000 €/QALY is considered as a threshold for the ICER, TNFis do not seem to be cost-effective among cDMARD naïve patients and patients with an insufficient response to cDMARDs. With thresholds of 50,000 to 100,000 €/QALY biologics might be cost-effective among patients with an inadequate response to cDMARDs. Standardization of multiattribute utility instruments and a validated standard conversion method

  11. The Cost-Effectiveness of Biologics for the Treatment of Rheumatoid Arthritis: A Systematic Review (United States)

    Joensuu, Jaana T.; Huoponen, Saara; Aaltonen, Kalle J.; Konttinen, Yrjö T.; Nordström, Dan; Blom, Marja


    Background and Objectives Economic evaluations provide information to aid the optimal utilization of limited healthcare resources. Costs of biologics for Rheumatoid arthritis (RA) are remarkably high, which makes these agents an important target for economic evaluations. This systematic review aims to identify existing studies examining the cost-effectiveness of biologics for RA, assess their quality and report their results systematically. Methods A literature search covering Medline, Scopus, Cochrane library, ACP Journal club and Web of Science was performed in March 2013. The cost-utility analyses (CUAs) of one or more available biological drugs for the treatment of RA in adults were included. Two independent investigators systematically collected information and assessed the quality of the studies. To enable the comparison of the results, all costs were converted to 2013 euro. Results Of the 4890 references found in the literature search, 41 CUAs were included in the current systematic review. While considering only direct costs, the incremental cost-effectiveness ratio (ICER) of the tumor necrosis factor inhibitors (TNFi) ranged from 39,000 to 1 273,000 €/quality adjusted life year (QALY) gained in comparison to conventional disease-modifying antirheumatic drugs (cDMARDs) in cDMARD naïve patients. Among patients with an insufficient response to cDMARDs, biologics were associated with ICERs ranging from 12,000 to 708,000 €/QALY. Rituximab was found to be the most cost-effective alternative compared to other biologics among the patients with an insufficient response to TNFi. Conclusions When 35,000 €/QALY is considered as a threshold for the ICER, TNFis do not seem to be cost-effective among cDMARD naïve patients and patients with an insufficient response to cDMARDs. With thresholds of 50,000 to 100,000 €/QALY biologics might be cost-effective among patients with an inadequate response to cDMARDs. Standardization of multiattribute utility instruments

  12. Non-uniform sediment incipient velocity

    Institute of Scientific and Technical Information of China (English)

    Haitao XU; Jinyou LU; Xiaobin LIU


    Based on the mechanism of non-uniform sediment incipient motion,the dragging force and uplift force coefficient expressions are put forward for the non-uniform bed material exposure and close alignment state.The incipient veiocity formula of the non-uniform sediment is then established.It is shown that the formula structure is reasonable,and fine particles of the non-uniform sediment are more difficult to set into motion than the same sized uniform particles,whereas coarser particles are easier to set into motion than their uniform equivalents.The validity of the formula is verified by field and experiment data.

  13. Effect of some botanical materials on certain biological aspects of the house fly, Musca domestica L

    Directory of Open Access Journals (Sweden)

    Nabawy A. I. Elkattan, Khalafalla S. Ahmed, Saadya M. Elbermawy and Rabab


    Full Text Available The effects of Lantana camara (leaves, Pelargonium zonale (leaves, Cupressus macrocarpa (leaves, Cyperus rotundus (whole plant and Acacia nilotica (seeds powders on some biological aspects of house fly, M. domestica L. were tested. The effects of three lethal concentrations LC25, LC50 and LC75 on the larval duration, pupation percent, pupal weight, pupal duration, adult emergence percent, sex ratio, adult longevity, and fecundity were determined. The induced malformed larvae, pupae and adults were recorded and photographed. The powders of the five plants were found to have promising effects in controlling this insect.

  14. Effective diffusion coefficient of biological liquids in porous calcium phosphate coatings (United States)

    Nazarenko, N. N.; Knyazeva, A. G.


    The study offers a method to estimate effective diffusion coefficients for transfer of biological liquids in porous materials. The method is based on the analysis of areas occupied by pores and solid materials on slice images. The possibility is shown for ascertaining a correlation between the effective coefficient and technological conditions because different structure and porosity are observed experimentally. The correlations of effective diffusion coefficients with the production voltage for different coating-base compositions, on which the coating was grown, have been built.

  15. Characterization of the angular memory effect of scattered light in biological tissues (United States)

    Schott, Sam; Bertolotti, Jacopo; Léger, Jean-Francois; Bourdieu, Laurent; Gigan, Sylvain


    High resolution optical microscopy is essential in neuroscience but suffers from scattering in biological tissues. It therefore grants access to superficial layers only. Recently developed techniques use scattered photons for imaging by exploiting angular correlations in transmitted light and could potentially increase imaging depths. But those correlations (`angular memory effect') are of very short range and, in theory, only present behind and not inside scattering media. From measurements on neural tissues and complementary simulations, we find that strong forward scattering in biological tissues can enhance the memory effect range (and thus the possible field-of-view) by more than an order of magnitude compared to isotropic scattering for $\\sim$1\\,mm thick tissue layers.

  16. Characterization of the angular memory effect of scattered light in biological tissues

    CERN Document Server

    Schott, Sam; Léger, Jean-Francois; Bourdieu, Laurent; Gigan, Sylvain


    High resolution optical microscopy is essential in neuroscience but suffers from scattering in biological tissues. It therefore grants access to superficial layers only. Recently developed techniques use scattered photons for imaging by exploiting angular correlations in transmitted light and could potentially increase imaging depths. But those correlations (`angular memory effect') are of very short range and, in theory, only present behind and not inside scattering media. From measurements on neural tissues and complementary simulations, we find that strong forward scattering in biological tissues can enhance the memory effect range (and thus the possible field-of-view) by more than an order of magnitude compared to isotropic scattering for $\\sim$1\\,mm thick tissue layers.

  17. 冷藏车温度场不均匀度对蔬菜保鲜效果的影响%Effects of refrigerated truck temperature field uniformity on preservation of vegetables

    Institute of Scientific and Technical Information of China (English)

    张哲; 李立民; 田津津; 郭永刚; 李曼


    distribution in the refrigerated truck, the temperature non-uniformity (S) has been defined. In this paper, three kinds of vegetables (baby cabbages, peppers, and flammulina velutipes) have been tested in the refrigerated truck under different conditions. The weight loss rate, membrane penetration rate, vitamin c content, and chlorophyll content were evaluated under different storage conditions with three kinds of air supply forms. Weight loss rate, membrane penetration rate, and vitamin c content were evaluated under different storage conditions with different temperature fields, with temperature non-uniformity values of SI=3.71, SII=5.68, and SIII=8.36. It was found that the effect of the temperature field on the quality of vegetables is significant. Results show that the uniform temperature field has a better effect on preservation. The reason for this is that the more uniform the temperature is distributed, the more uniform the cold energy is distributed. In doing so, vegetables can be kept at the appropriate temperature environment; thus, the quality of vegetables can be kept for a long time. The three kinds of vegetables (baby cabbages, peppers, and flammulina velutipes) show the same result. This study can provide a reference for the optimization design of the refrigerated truck. The results can contribute to improving the quality control of vegetables or agricultural products during the process of refrigerated transport.%为了提高在冷藏运输过程中果蔬的品质,研究了冷藏车厢内部的温度场。冷藏车内合理的温度场,可以保证冷量的均匀分配,节约能耗,降低干耗及冻害损失,提高果蔬保鲜质量。该文以质量损失率、细胞膜渗透率、维生素C含量和叶绿素含量的变化作为评价指标,对不均匀度分别为3.71、5.68和8.36的温度场中贮藏的3种蔬菜(娃娃菜、尖椒和金针菇)品质的变化情况进行比较。结果表明,冷藏车内温度场的均匀程度与果蔬

  18. Effect of non-crop vegetation types on conservation biological control of pests in olive groves



    Conservation biological control (CBC) is an environmentally sound potential alternative to the use of chemical insecticides. It involves modifications of the environment to promote natural enemy activity on pests. Despite many CBC studies increasing abundance of natural enemies, there are far fewer demonstrations of reduced pest density and very little work has been conducted in olive crops. In this study we investigated the effects of four forms of non-crop vegetation on the abundance of two...

  19. Cumulative and Synergistic Effects of Physical, Biological, and Acoustic Signals on Marine Mammal Habitat Use (United States)


    seasonal breakup of the ice has begun. The bowhead whales detections finally disappear as these mammals begin their annual migration to the Arctic Ocean...Final Report Cumulative and Synergistic Effects of Physical, Biological, and Acoustic Signals on Marine Mammal Habitat Use Jeffrey A Nystuen...signals impact marine mammal habitat use. This is especially critical in areas like the Bering Sea where global climate change can lead to rapid changes

  20. Effects of organic amendment on soil quality as assessed by biological indicators


    Sultana, Salma


    Soil quality decline is one of the most predominant effect deriving from human activities. In particular, intensive agricultural management can affect negatively soils, principally due to rapid depletion of soil organic matter, that affects, in turn, soil physical, chemical and biological properties. The declining trend of soil quality coupled with mismanagement of agricultural production is pose a serious threat to sustainability of intensive agriculture. Sustainable intensive agriculture is...

  1. Biological Effects of Short, High-Level Exposure to Gases: Nitrogen Oxides. (United States)


    SUPPLEMENTARY NOT ES3 This project was one of four under the same contract; the others covered ammonia , carbon monoxide, and sulfur dioxide. 3 IS. KEY wOROS...characterize the biological responses to short, high-level exposures to four gases associated with certain Army weapons systems ( ammonia , carbon monoxide...20- i --- 7 (2) Biochemical and Other Effects Buckley and BalchumlO found biochemical changes, principally in enzyme activity of the liver, spleen

  2. Computation of the effective mechanical response of biological networks accounting for large configuration changes. (United States)

    El Nady, K; Ganghoffer, J F


    The asymptotic homogenization technique is involved to derive the effective elastic response of biological membranes viewed as repetitive beam networks. Thereby, a systematic methodology is established, allowing the prediction of the overall mechanical properties of biological membranes in the nonlinear regime, reflecting the influence of the geometrical and mechanical micro-parameters of the network structure on the overall response of the equivalent continuum. Biomembranes networks are classified based on nodal connectivity, so that we analyze in this work 3, 4 and 6-connectivity networks, which are representative of most biological networks. The individual filaments of the network are described as undulated beams prone to entropic elasticity, with tensile moduli determined from their persistence length. The effective micropolar continuum evaluated as a continuum substitute of the biological network has a kinematics reflecting the discrete network deformation modes, involving a nodal displacement and a microrotation. The statics involves the classical Cauchy stress and internal moments encapsulated into couple stresses, which develop internal work in duality to microcurvatures reflecting local network undulations. The relative ratio of the characteristic bending length of the effective micropolar continuum to the unit cell size determines the relevant choice of the equivalent medium. In most cases, the Cauchy continuum is sufficient to model biomembranes. The peptidoglycan network may exhibit a re-entrant hexagonal configuration due to thermal or pressure fluctuations, for which micropolar effects become important. The homogenized responses are in good agreement with FE simulations performed over the whole network. The predictive nature of the employed homogenization technique allows the identification of a strain energy density of a hyperelastic model, for the purpose of performing structural calculations of the shape evolutions of biomembranes.

  3. [Properties and biological effect of dust of various artificial mineral fibers]. (United States)

    Elovskaja, L T; Werner, I; Kupina, L M; Loscilov, J A; Efremov, L D


    Developments and use of man-made mineral fibres are important for the progress in some technical fields. In the last years the number of man-made mineral fibres increased extraordinarily. For the medical evaluation it is necessary to determine the physico-chemical characteristics of the man-made mineral fibre dust and its biological effects in animal experiments. The results of the investigations are described.

  4. On the effect of prestrain and residual stress in thin biological membranes. (United States)

    Rausch, Manuel K; Kuhl, Ellen


    Understanding the difference between ex vivo and in vivo measurements is critical to interpret the load carrying mechanisms of living biological systems. For the past four decades, the ex vivo stiffness of thin biological membranes has been characterized using uniaxial and biaxial tests with remarkably consistent stiffness parameters, even across different species. Recently, the in vivo stiffness was characterized using combined imaging techniques and inverse finite element analyses. Surprisingly, ex vivo and in vivo stiffness values differed by up to three orders of magnitude. Here, for the first time, we explain this tremendous discrepancy using the concept of prestrain. We illustrate the mathematical modeling of prestrain in nonlinear continuum mechanics through the multiplicative decomposition of the total elastic deformation into prestrain-induced and load-induced parts. Using in vivo measured membrane kinematics and associated pressure recordings, we perform an inverse finite element analysis for different prestrain levels and show that the resulting membrane stiffness may indeed differ by four orders of magnitude depending on the prestrain level. Our study motivates the hypothesis that prestrain is important to position thin biological membranes in vivo into their optimal operating range, right at the transition point of the stiffening regime. Understanding the effect of prestrain has direct clinical implications in regenerative medicine, medical device design, and and tissue engineering of replacement constructs for thin biological membranes.

  5. Effect of the flavonoid rutin on the biology of Spodoptera frugiperda (Lepidoptera: Noctuidae

    Directory of Open Access Journals (Sweden)

    Talita Roberta Ferreira Borges Silva


    Full Text Available The fall armyworm Spodoptera frugiperda (J.E. Smith (Lepidoptera: Noctuidae is a major pest of maize crops in Brazil. The effects of plant metabolites on the biology and behavior of insects is little studied. The aim of the study was to evaluate the activity of rutin on the biology of the S. frugiperda by using artificial diets containing rutin. The study evaluated four treatments: regular diet (control group and diets containing 1.0, 2.0 and 3.0 mg g-1 of rutin. The following biological variables parameters of the larvae were evaluated daily: development time (days, larval and pupal weight (g and viability (%, adult longevity and total life cycle (days. A completely randomized experimental design was used with 25 replication. The rutin flavonoid negatively affected the biology of S. frugiperda by prolonging the larval development time, reducing the weight of larvae and pupae and decreasing the viability of the pupae. The addition of different concentrations of rutin prolonged the S. frugiperda life cycle. The use of plant with insecticidal activity has the potential with strategy in IPM.

  6. Uniform generation of combinatorial structures

    Energy Technology Data Exchange (ETDEWEB)

    Zito, M.; Pu, I.; Amos, M.; Gibbons, A. [Univ. of Warwick, Coventry (United Kingdom)


    We describe several RNC algorithms for generating graphs and subgraphs uniformly at random. For example, unlabelled undirected graphs are generated in O(log{sup 3} n lg lg n) time using O({epsilon}n{sup 1.5}/lg{sup 3} n lg lg n) processors if their number is n lg lg n known in advance and in O(lg n) time using O ({epsilon}n{sup 2}/lg n) processors otherwise. In both cases the error probability is the inverse of a polynomial in {epsilon}. Thus {epsilon} may be chosen to trade-off processors for error probability. Also, for an arbitrary graph, we describe RNC algorithms for the uniform generation of its subgraphs that are either non-simple paths or spanning trees. The work measure for the subgraph algorithms is essentially determined by the transitive closure bottleneck. As for sequential algorithms, the general notion of constructing generators from counters also applies to parallel algorithms although this approach is not employed by all the algorithms of this paper.

  7. Relative biological effectiveness for photons: implication of complex DNA double-strand breaks as critical lesions (United States)

    Liang, Ying; Fu, Qibin; Wang, Xudong; Liu, Feng; Yang, Gen; Luo, Chunxiong; Ouyang, Qi; Wang, Yugang


    Current knowledge in radiobiology ascribes the adverse biological effects of ionizing radiation primarily to the induction of DNA double-strand breaks (DSBs), which is supposed to be potentially lethal and may be converted to lethal damage due to misrepair. Soft and ultrasoft x-rays have been found to bear elevated biological effectiveness for cell killing compared with conventional x-rays or 60Co γ-rays. This phenomenon is qualitatively interpreted as the increased level of DSB induction for low energy photons, however, a thorough quantitative reasoning is lacking. Here, we systematically compared the relative biological effectiveness (RBE) with relative DSB induction for photons from several hundreds of eV up to MeV. Although there is an approximate two-fold increase in the yields of DSB for low energy photons found in our calculation and a large number of experimental measurements, it is far from enough to account for the three- to four-fold increase in RBE. Further theoretical investigations show that DSB complexity (additional single-strand breaks and base damage within 10 base pairs) increases notably for low energy photons, which largely reconciles the discrepancy between RBE and DSB induction. Our theoretical results are in line with accumulating experimental evidence that complex DSBs are refractory to repair machinery and may contribute predominantly to the formation of lethal damage.

  8. Deciphering the biological effects of acupuncture treatment modulating multiple metabolism pathways. (United States)

    Zhang, Aihua; Yan, Guangli; Sun, Hui; Cheng, Weiping; Meng, Xiangcai; Liu, Li; Xie, Ning; Wang, Xijun


    Acupuncture is an alternative therapy that is widely used to treat various diseases. However, detailed biological interpretation of the acupuncture stimulations is limited. We here used metabolomics and proteomics technology, thereby identifying the serum small molecular metabolites into the effect and mechanism pathways of standardized acupuncture treatments at 'Zusanli' acupoint which was the most often used acupoint in previous reports. Comprehensive overview of serum metabolic profiles during acupuncture stimulation was investigated. Thirty-four differential metabolites were identified in serum metabolome and associated with ten metabolism pathways. Importantly, we have found that high impact glycerophospholipid metabolism, fatty acid metabolism, ether lipid metabolism were acutely perturbed by acupuncture stimulation. As such, these alterations may be useful to clarify the biological mechanism of acupuncture stimulation. A series of differentially expressed proteins were identified and such effects of acupuncture stimulation were found to play a role in transport, enzymatic activity, signaling pathway or receptor interaction. Pathway analysis further revealed that most of these proteins were found to play a pivotal role in the regulation of multiple metabolism pathways. It demonstrated that the metabolomics coupled with proteomics as a powerful approach for potential applications in understanding the biological effects of acupuncture stimulation.

  9. Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO (United States)

    Cucinotta, F. A.; Wilson, J. W.; Williams, J. R.; Dicello, J. F.


    We compare models of radiation transport and biological response to physical and biological dosimetry results from astronauts on the Mir space station. Transport models are shown to be in good agreement with physical measurements and indicate that the ratio of equivalent dose from the Galactic Cosmic Rays (GCR) to protons is about 3/2:1 and that this ratio will increase for exposures to internal organs. Two biological response models are used to compare to the Mir biodosimetry for chromosome aberration in lymphocyte cells; a track-structure model and the linear-quadratic model with linear energy transfer (LET) dependent weighting coefficients. These models are fit to in vitro data for aberration formation in human lymphocytes by photons and charged particles. Both models are found to be in reasonable agreement with data for aberrations in lymphocytes of Mir crew members: however there are differences between the use of LET dependent weighting factors and track structure models for assigning radiation quality factors. The major difference in the models is the increased effectiveness predicted by the track model for low charge and energy ions with LET near 10 keV/micrometers. The results of our calculations indicate that aluminum shielding, although providing important mitigation of the effects of trapped radiation, provides no protective effect from the galactic cosmic rays (GCR) in low-earth orbit (LEO) using either equivalent dose or the number of chromosome aberrations as a measure until about 100 g/cm 2 of material is used.

  10. Nanometallomics: an emerging field studying the biological effects of metal-related nanomaterials. (United States)

    Li, Yu-Feng; Gao, Yuxi; Chai, Zhifang; Chen, Chunying


    Metallomics, focusing on the global and systematic understanding of the metal uptake, trafficking, role and excretion in biological systems, has attracted more and more attention. Metal-related nanomaterials, including metallic and metal-containing nanomaterials, have unique properties compared to their micro-scaled counterparts and therefore require special attention. The small size effect, surface effect, and quantum size effect directly influence the physicochemical properties of nanostructured materials and their fate and behavior in biota. However, to our knowledge, the metallomics itself did not touch this special category of materials yet. Therefore, the term "nanometallomics" is proposed and the systematic study on the absorption, distribution, metabolism, excretion (ADME) behavior of metal-related nanomaterials in biological systems and their interactions with genes, proteins and other biomolecules will be reviewed. The ADME behavior of metal-related nanomaterials in the biological systems is influenced by their physicochemical properties, the exposure route, and the microenvironment of the deposition site. Nanomaterials may not only interact directly or indirectly with genes, proteins and other molecules to cause DNA damage, genotoxicity, immunotoxicity, and cytotoxicity, but also stimulate the immune responses, circumvent tumor resistance and inhibit tumor metastasis. Nanometallomics needs to be integrated with other omics sciences, such as genomics, proteomics and metabolomics, to explore the biomedical data and obtain the overall knowledge of underlying mechanisms, and therefore to improve the application performance and to reduce the potential risk of metal-related nanomaterials.

  11. Comparison of HeNe laser and sinusoidal non-uniform magnetic field seed pre-sowing treatment effect on Glycine max (Var 90-I) germination, growth and yield. (United States)

    Asghar, Tehseen; Iqbal, Munawar; Jamil, Yasir; Zia-Ul-Haq; Nisar, Jan; Shahid, Muhammad


    Recently, laser and magnetic field pre-sowing seed treatments attracted the attention of the scientific community in response to their positive effect on plant characteristics and the present study was exemplified for Glycine max Var 90-I. Seeds were exposed to laser (HeNe-wave length 632nm and density power of 1mW/cm(2)) and magnetic field (sinusoidal non-uniform-50, 75 and 100mT for 3, 5min with exposure) and seed germination, seedling growth and yield attributes were compared. The germination (mean germination, germination percentage, emergence index, germination speed, relative germination coefficient, emergence coefficient of uniformity) growth (root dry weight, root length, shoot fresh weight and shoot dry weight, leaf dry & fresh weight, root fresh weight, leaf area, shoot length, plant total dry weight at different stages, stem diameter, number of leaves, vigor index I & II), biochemical (essential oil) and yield attributes (seed weight, count) were enhanced significantly in response to both laser and magnetic field treatments. However, magnetic field treatment furnished slightly higher response versus laser except relative water contents, whole plant weight and shoot length. Results revealed that both laser and magnetic field pre-sowing seed treatments affect the germination, seedling growth, and yield characteristics positively and could possibly be used to enhance Glycine max productivity.

  12. Uniform algal growth in photobioreactors using surface scatterers (United States)

    Ahsan, Syed S.; Pereyra, Brandon; Erickson, David


    Cultures of algae, such as cyanobacteria, are a promising source of renewable energy. However, algal growth is highly dependent on light intensity and standard photobioreactors do a poor job of distributing light uniformly for algal utilization due to shading effects in dense algal cultures. Engineered scattering schemes are already employed in current slab-waveguide technologies, like edge-lit LEDs. Stacking such slab-waveguides that uniformly distribute light could potentially yield photobioreactors to overcome the shading effect and grow extremely high densities of algal cultures that would lower monetary and energetic costs. Here, we characterize and design a scattering scheme for specific application within photobioreactors which employs a gradient distribution of surface scatterers with uniform lateral scattering intensity. This uniform scattering scheme is shown to be superior for algal cultivation.

  13. New insight into the molecular mechanisms of the biological effects of DNA minor groove binders.

    Directory of Open Access Journals (Sweden)

    Xinbo Zhang

    Full Text Available BACKGROUND: Bisbenzimides, or Hoechst 33258 (H258, and its derivative Hoechst 33342 (H342 are archetypal molecules for designing minor groove binders, and widely used as tools for staining DNA and analyzing side population cells. They are supravital DNA minor groove binders with AT selectivity. H342 and H258 share similar biological effects based on the similarity of their chemical structures, but also have their unique biological effects. For example, H342, but not H258, is a potent apoptotic inducer and both H342 and H258 can induce transgene overexpression in in vitro studies. However, the molecular mechanisms by which Hoechst dyes induce apoptosis and enhance transgene overexpression are unclear. METHODOLOGY/PRINCIPAL FINDINGS: To determine the molecular mechanisms underlying different biological effects between H342 and H258, microarray technique coupled with bioinformatics analyses and multiple other techniques has been utilized to detect differential global gene expression profiles, Hoechst dye-specific gene expression signatures, and changes in cell morphology and levels of apoptosis-associated proteins in malignant mesothelioma cells. H342-induced apoptosis occurs in a dose-dependent fashion and is associated with morphological changes, caspase-3 activation, cytochrome c mitochondrial translocation, and cleavage of apoptosis-associated proteins. The antagonistic effect of H258 on H342-induced apoptosis indicates a pharmacokinetic basis for the two dyes' different biological effects. Differential global gene expression profiles induced by H258 and H342 are accompanied by unique gene expression signatures determined by DNA microarray and bioinformatics software, indicating a genetic basis for their different biological effects. CONCLUSIONS/SIGNIFICANCE: A unique gene expression signature associated with H342-induced apoptosis provides a new avenue to predict and classify the therapeutic class of minor groove binders in the drug

  14. Novel Biological Approaches for Testing the Contributions of Single DSBs and DSB Clusters to the Biological Effects of High LET Radiation. (United States)

    Mladenova, Veronika; Mladenov, Emil; Iliakis, George


    The adverse biological effects of ionizing radiation (IR) are commonly attributed to the generation of DNA double-strand breaks (DSBs). IR-induced DSBs are generated by clusters of ionizations, bear damaged terminal nucleotides, and frequently comprise base damages and single-strand breaks in the vicinity generating a unique DNA damage-clustering effect that increases DSB "complexity." The number of ionizations in clusters of different radiation modalities increases with increasing linear energy transfer (LET), and is thought to determine the long-known LET-dependence of the relative biological effectiveness (RBE). Multiple ionizations may also lead to the formation of DSB clusters, comprising two or more DSBs that destabilize chromatin further and compromise overall processing. DSB complexity and DSB-cluster formation are increasingly considered in the development of mathematical models of radiation action, which are then "tested" by fitting available experimental data. Despite a plethora of such mathematical models the ultimate goal, i.e., the "a priori" prediction of the radiation effect, has not yet been achieved. The difficulty partly arises from unsurmountable difficulties in testing the fundamental assumptions of such mathematical models in defined biological model systems capable of providing conclusive answers. Recently, revolutionary advances in methods allowing the generation of enzymatic DSBs at random or in well-defined locations in the genome, generate unique testing opportunities for several key assumptions frequently fed into mathematical modeling - including the role of DSB clusters in the overall effect. Here, we review the problematic of DSB-cluster formation in radiation action and present novel biological technologies that promise to revolutionize the way we address the biological consequences of such lesions. We describe new ways of exploiting the I-SceI endonuclease to generate DSB-clusters at random locations in the genome and describe the

  15. Calculation of Uniform of Beam Scanning

    Institute of Scientific and Technical Information of China (English)


    For the electron beam application, it is always scanned by a dipole magnet. The uniform of the scanning has great influence for some application, such as the irradiation of the thyristor. There are two methods for improving the scanning uniform:

  16. Biological Maturity Status Strongly Intensifies the Relative Age Effect in Alpine Ski Racing (United States)

    Müller, Lisa; Müller, Erich; Hildebrandt, Carolin; Raschner, Christian


    The relative age effect (RAE) is a well-documented phenomenon in youth sports. This effect exists when the relative age quarter distribution of selected athletes shows a biased distribution with an over-representation of relatively older athletes. In alpine ski racing, it exists in all age categories (national youth levels up to World Cup). Studies so far could demonstrate that selected ski racers are relatively older, taller and heavier. It could be hypothesized that relatively younger athletes nearly only have a chance for selection if they are early maturing. However, surprisingly this influence of the biological maturity status on the RAE could not be proven, yet. Therefore, the aim of the present study was to investigate the influence of the biological maturity status on the RAE in dependence of the level of competition. The study investigated 372 elite youth ski racers: 234 provincial ski racers (P-SR; high level of competition) and 137 national ski racers (N-SR; very high level of competition). Anthropometric characteristics were measured to calculate the age at peak height velocity (APHV) as an indicator of the biological maturity status. A significant RAE was present among both P-SR and N-SR, with a larger effect size among the latter group. The N-SR significantly differed in APHV from the P-SR. The distribution of normal, early and late maturing athletes significantly differed from the expected normal distribution among the N-SR, not among the P-SR. Hardly any late maturing N-SR were present; 41.7% of the male and 34% of the female N-SR of the last relative age quarter were early maturing. These findings clearly demonstrate the significant influence of the biological maturity status on the selection process of youth alpine ski racing in dependence of the level of competition. Relatively younger athletes seem to have a chance of selection only if they are early maturing. PMID:27504832

  17. Effects of transgenic Bt cotton on soil fertility and biology under field conditions in subtropical inceptisol. (United States)

    Singh, Raman Jeet; Ahlawat, I P S; Singh, Surender


    Although there is large-scale adoption of Bt cotton by the farmers because of immediate financial gain, there is concern that Bt crops release Bt toxins into the soil environment which reduces soil chemical and biological activities. However, the majorities of such studies were mainly performed under pot experiments, relatively little research has examined the direct and indirect effects of associated cover crop of peanut with fertilization by combined application of organic and inorganic sources of nitrogen under field conditions. We compared soil chemical and biological parameters of Bt cotton with pure crop of peanut to arrive on a valid conclusion. Significantly higher dehydrogenase enzyme activity and KMnO(4)-N content of soil were observed in Bt cotton with cover crop of peanut over pure Bt cotton followed by pure peanut at all the crop growth stages. However, higher microbial population was maintained by pure peanut over intercropped Bt cotton, but these differences were related to the presence of high amount of KMnO(4)-N content of soil. By growing cover crop of peanut between Bt cotton rows, bacteria, fungi, and actinomycetes population increased by 60%, 14%, and 10%, respectively, over Bt cotton alone. Bt cotton fertilized by combined application of urea and farm yard manure (FYM) maintained higher dehydrogenase enzyme activity, KMnO(4)-N content of soil and microbial population over urea alone. Significant positive correlations were observed for dry matter accumulation, dehydrogenase enzyme activity, KMnO(4)-N content, and microbial population of soil of Bt cotton, which indicates no harmful effects of Bt cotton on soil biological parameters and associated cover crop. Our results suggest that inclusion of cover crop of peanut and FYM in Bt cotton enhanced soil chemical and biological parameters which can mask any negative effect of the Bt toxin on microbial activity and thus on enzymatic activities.

  18. Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting. (United States)

    DeBord, D Gayle; Burgoon, Lyle; Edwards, Stephen W; Haber, Lynne T; Kanitz, M Helen; Kuempel, Eileen; Thomas, Russell S; Yucesoy, Berran


    In a recent National Research Council document, new strategies for risk assessment were described to enable more accurate and quicker assessments. This report suggested that evaluating individual responses through increased use of bio-monitoring could improve dose-response estimations. Identification of specific biomarkers may be useful for diagnostics or risk prediction as they have the potential to improve exposure assessments. This paper discusses systems biology, biomarkers of effect, and computational toxicology approaches and their relevance to the occupational exposure limit setting process. The systems biology approach evaluates the integration of biological processes and how disruption of these processes by chemicals or other hazards affects disease outcomes. This type of approach could provide information used in delineating the mode of action of the response or toxicity, and may be useful to define the low adverse and no adverse effect levels. Biomarkers of effect are changes measured in biological systems and are considered to be preclinical in nature. Advances in computational methods and experimental -omics methods that allow the simultaneous measurement of families of macromolecules such as DNA, RNA, and proteins in a single analysis have made these systems approaches feasible for broad application. The utility of the information for risk assessments from -omics approaches has shown promise and can provide information on mode of action and dose-response relationships. As these techniques evolve, estimation of internal dose and response biomarkers will be a critical test of these new technologies for application in risk assessment strategies. While proof of concept studies have been conducted that provide evidence of their value, challenges with standardization and harmonization still need to be overcome before these methods are used routinely.

  19. Biological Maturity Status Strongly Intensifies the Relative Age Effect in Alpine Ski Racing. (United States)

    Müller, Lisa; Müller, Erich; Hildebrandt, Carolin; Raschner, Christian


    The relative age effect (RAE) is a well-documented phenomenon in youth sports. This effect exists when the relative age quarter distribution of selected athletes shows a biased distribution with an over-representation of relatively older athletes. In alpine ski racing, it exists in all age categories (national youth levels up to World Cup). Studies so far could demonstrate that selected ski racers are relatively older, taller and heavier. It could be hypothesized that relatively younger athletes nearly only have a chance for selection if they are early maturing. However, surprisingly this influence of the biological maturity status on the RAE could not be proven, yet. Therefore, the aim of the present study was to investigate the influence of the biological maturity status on the RAE in dependence of the level of competition. The study investigated 372 elite youth ski racers: 234 provincial ski racers (P-SR; high level of competition) and 137 national ski racers (N-SR; very high level of competition). Anthropometric characteristics were measured to calculate the age at peak height velocity (APHV) as an indicator of the biological maturity status. A significant RAE was present among both P-SR and N-SR, with a larger effect size among the latter group. The N-SR significantly differed in APHV from the P-SR. The distribution of normal, early and late maturing athletes significantly differed from the expected normal distribution among the N-SR, not among the P-SR. Hardly any late maturing N-SR were present; 41.7% of the male and 34% of the female N-SR of the last relative age quarter were early maturing. These findings clearly demonstrate the significant influence of the biological maturity status on the selection process of youth alpine ski racing in dependence of the level of competition. Relatively younger athletes seem to have a chance of selection only if they are early maturing.

  20. The Power Unit Coordinated Control via Uniform Differential Evolution


    Zain Abdalla Zahran; Rui Feng Shi; Xiang Jie Liu


    This paper modified the differential evolution (DE) algorithm adaptively to solve the power unit coordinated control (PUCC) problem. It was modified in two aspects: 1) a uniform initialization, which was controlled and regulated by a zone factor (m), 2) a regular mutation process, to develop an effective searching process and improve the convergence of the basic DE algorithm. A numerical case study was employed to verify the performance of our proposed uniform differential evolution (UDE) a...

  1. The study of biological effects of electromagnetic mobile phone radiation on experimental animals by combining numerical modeling and experimental research

    Directory of Open Access Journals (Sweden)

    Dejan Krstić


    Full Text Available In order to study biological effects of electromagneticradiation, it is essential to know the real values of field componentsthat penetrated the tissue. The study of biological effects is usuallyperformed on experimental animals. The biological effects observedon experimental animals should be linked with penetrating field inthe tissue. The penetrating electromagnetic field is almost impossibleto measure; therefore, modeling process must be carried out and thefield components in models of experimental animals could becalculated. This paper presents an approach to modeling of fieldpenetration and gives contribution to understanding the real effects of the fields and the sensitivity of tissues to electromagnetic radiation generated by mobile phone.

  2. Biological Effects of Gamma-Ray Bursts: Critical distances for severe damage on the biota

    CERN Document Server

    Galante, D; Galante, Douglas; Horvath, Jorge Ernesto


    We present in this work a unified, quantitative synthesis of analytical and numerical calculations of the effects caused on an Earth-like planet by a Gamma-Ray Burst (GRB), considering atmospheric and biological implications. The main effects of the illumination by a GRB are classified in four distinct ones and analyzed separately, namely the direct gamma radiation transmission, UV flash, ozone layer depletion and cosmic rays. The effectiveness of each of these effects is compared and lethal distances for significant biological damage are given for each one. We find that the first three effects have potential to cause global environmental changes and biospheric damages, even if the source is located at great distances (perhaps up to ~ 100 kpc). Instead, cosmic rays would only be a serious threat for very close sources. As a concrete example of a recorded similar event, the effects of the giant flare from SGR1806-20 of Dec 27, 2004 could cause on the biosphere are addressed. In spite of not belonging to the so...

  3. Comparing Effects of Biologic Agents in Treating Patients with Rheumatoid Arthritis: A Multiple Treatment Comparison Regression Analysis.

    Directory of Open Access Journals (Sweden)

    Ingunn Fride Tvete

    Full Text Available Rheumatoid arthritis patients have been treated with disease modifying anti-rheumatic drugs (DMARDs and the newer biologic drugs. We sought to compare and rank the biologics with respect to efficacy. We performed a literature search identifying 54 publications encompassing 9 biologics. We conducted a multiple treatment comparison regression analysis letting the number experiencing a 50% improvement on the ACR score be dependent upon dose level and disease duration for assessing the comparable relative effect between biologics and placebo or DMARD. The analysis embraced all treatment and comparator arms over all publications. Hence, all measured effects of any biologic agent contributed to the comparison of all biologic agents relative to each other either given alone or combined with DMARD. We found the drug effect to be dependent on dose level, but not on disease duration, and the impact of a high versus low dose level was the same for all drugs (higher doses indicated a higher frequency of ACR50 scores. The ranking of the drugs when given without DMARD was certolizumab (ranked highest, etanercept, tocilizumab/ abatacept and adalimumab. The ranking of the drugs when given with DMARD was certolizumab (ranked highest, tocilizumab, anakinra/rituximab, golimumab/ infliximab/ abatacept, adalimumab/ etanercept [corrected]. Still, all drugs were effective. All biologic agents were effective compared to placebo, with certolizumab the most effective and adalimumab (without DMARD treatment and adalimumab/ etanercept (combined with DMARD treatment the least effective. The drugs were in general more effective, except for etanercept, when given together with DMARDs.

  4. Attitudes of Parents about School Uniforms. (United States)

    West, Charles K.; Tidwell, Diane K.; Bomba, Anne K.; Elmore, Patsy Alexander


    Responses from 144 parents of fourth graders showed that 56% favored uniforms in public schools; most agreed that uniforms contributed to a conducive learning environment, promoted school spirit, and discouraged violence; and most disagreed that uniforms cost more than other types of clothing. (SK)

  5. Cost-effective management alternatives for Snake river chinook salmon: A biological-economic synthesis (United States)

    Halsing, D.L.; Moore, M.R.


    The mandate to increase endangered salmon populations in the Columbia River Basin of North America has created a complex, controversial resource-management issue. We constructed an integrated assessment model as a tool for analyzing biological-economic trade-offs in recovery of Snake River spring- and summer-run chinook salmon (Oncorhynchus tshawytscha). We merged 3 frameworks: a salmon-passage model to predict migration and survival of smolts; an age-structured matrix model to predict long-term population growth rates of salmon stocks; and a cost-effectiveness analysis to determine a set of least-cost management alternatives for achieving particular population growth rates. We assessed 6 individual salmon-management measures and 76 management alternatives composed of one or more measures. To reflect uncertainty, results were derived for different assumptions of effectiveness of smolt transport around dams. Removal of an estuarine predator, the Caspian Tern (Sterna caspia), was cost-effective and generally increased long-term population growth rates regardless of transport effectiveness. Elimination of adult salmon harvest had a similar effect over a range of its cost estimates. The specific management alternatives in the cost-effective set depended on assumptions about transport effectiveness. On the basis of recent estimates of smolt transport effectiveness, alternatives that discontinued transportation or breached dams were prevalent in the cost-effective set, whereas alternatives that maximized transportation dominated if transport effectiveness was relatively high. More generally, the analysis eliminated 80-90% of management alternatives from the cost-effective set. Application of our results to salmon management is limited by data availability and model assumptions, but these limitations can help guide research that addresses critical uncertainties and information. Our results thus demonstrate that linking biology and economics through integrated models can

  6. Lethal and Sublethal Effects of Fenpropathrin on the Biological Performance of Scolothrips longicornis (Thysanoptera: Thripidae)

    DEFF Research Database (Denmark)

    Pakyari, Hajar; Enkegaard, Annie


    affected the biological characteristics of treated females of S. longicornis, the most noticeable effects being a shortening of female life span by >70% accompanied by large reductions in oviposition period and fecundity. The offspring of females treated with low-lethal concentrations of fenpropathrin...... likewise had significantly reduced longevity, oviposition period, and fecundity, although not to the same extent as experienced by their mothers. Their juvenile development time was, however, not affected. These effects on the offspring were reflected in reduced rates of population increase and increased...

  7. Effect of radiation and fungal treatment on ligno celluloses and their biological activity

    Energy Technology Data Exchange (ETDEWEB)

    Lam, N.D.; Nagasawa, Naotsugu; Kume, Tamikazu E-mail:


    Effects of high-dose irradiation and fungal treatment on some kinds of lignocellulose material were investigated in order to assess the potential effects of bioactive substances on plants. Each treatment and combination of treatments significantly altered the components of lignocellulose materials. Irradiation strongly affected all plant materials, causing a series of changes in physico-chemical parameters such as solubilization during solvent extraction and losses of fibre components. By these degradations, certain biologically active substances formed and acted as antagonists of auxin-induced growth.

  8. High school teachers' perspectives on effective approaches for teaching biology to students with special needs (United States)

    Kos, Agnieszka

    The demands of national educational reforms require high school biology teachers to provide high quality instruction to students with and without special needs. The reforms, however, do not provide teachers with adequate teaching strategies to meet the needs of all students in the same context. The purpose of this grounded theory study was to understand high school biology teachers' perspectives, practices, and challenges in relation to teaching students with special needs. This approach was used to develop a substantive model for high school biology teachers who are challenged with teaching students with and without special needs. Data were collected via in-depth interviews with 15 high school teachers in a Midwestern school district. The data were analyzed using open coding, axial coding, and selective coding procedures in accordance with the grounded theory approach. Essential model components included skills and training for teachers, classroom management strategies, teaching strategies, and student skills. The emergent substantive theory indicated that that teacher preparation and acquired skills greatly influence the effectiveness of inclusion implementation. Key findings also indicated the importance of using of a variety of instructional strategies and classroom management strategies that address students' special needs and their learning styles. This study contributes to social change by providing a model for teaching students and effectively implementing inclusion in regular science classrooms. Following further study, this model may be used to support teacher professional development and improve teaching practices that in turn may improve science literacy supported by the national educational reforms.

  9. Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy

    Institute of Scientific and Technical Information of China (English)



    ObjectiveThe custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder (SNOP) in wall materials and surveys customers in order to improve allergic symptoms. MethodsTo investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP (CCSNOP), and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth (NWC). Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS (Profile of Mood Status) and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. ResultsResults indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-1, and tumor necrosis factor-α increased following a stay in CCSNOP. ConclusionThis ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.

  10. Effects of physical therapy for the management of patients with ankylosing spondylitis in the biological era. (United States)

    Giannotti, Erika; Trainito, Sabina; Arioli, Giovanni; Rucco, Vincenzo; Masiero, Stefano


    Exercise is considered a fundamental tool for the management of ankylosing spondylitis (AS), in combination with pharmacological therapy that with the advent of biological therapy has improved dramatically the control of signs and symptoms of this challenging disease. Current evidence shows that a specific exercise protocol has not been validated yet. The purpose of this review is to update the most recent evidence (July 2010-November 2013) about physiotherapy in AS, analyzing the possible role and synergistic interactions between exercise and biological drugs. From 117 studies initially considered, only 15 were included in the review. The results support a multimodal approach, including educational sessions, conducted in a group setting, supervised by a physiotherapist and followed by a maintaining home-based regimen. Spa exercise and McKenzie, Heckscher, and Pilates methods seem promising in AS rehabilitation, but their effectiveness should be further investigated in future randomized controlled trials (RCTs). When performed in accordance with the American College of Sports Medicine guidelines, cardiovascular training has been proven safe and effective and should be included in AS rehabilitation protocols. Exercise training plays an important role in the biological era, being now applicable to stabilized patients, leading ultimately to a better management of AS by physiatrists and rheumatologists throughout the world. On the basis of the current evidence, further research should aim to determine which exercise protocols should be recommended.

  11. The origin of neutron biological effectiveness as a function of energy (United States)

    Baiocco, G.; Barbieri, S.; Babini, G.; Morini, J.; Alloni, D.; Friedland, W.; Kundrát, P.; Schmitt, E.; Puchalska, M.; Sihver, L.; Ottolenghi, A.


    The understanding of the impact of radiation quality in early and late responses of biological targets to ionizing radiation exposure necessarily grounds on the results of mechanistic studies starting from physical interactions. This is particularly true when, already at the physical stage, the radiation field is mixed, as it is the case for neutron exposure. Neutron Relative Biological Effectiveness (RBE) is energy dependent, maximal for energies ~1 MeV, varying significantly among different experiments. The aim of this work is to shed light on neutron biological effectiveness as a function of field characteristics, with a comprehensive modeling approach: this brings together transport calculations of neutrons through matter (with the code PHITS) and the predictive power of the biophysical track structure code PARTRAC in terms of DNA damage evaluation. Two different energy dependent neutron RBE models are proposed: the first is phenomenological and based only on the characterization of linear energy transfer on a microscopic scale; the second is purely ab-initio and based on the induction of complex DNA damage. Results for the two models are compared and found in good qualitative agreement with current standards for radiation protection factors, which are agreed upon on the basis of RBE data. PMID:27654349

  12. Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring (United States)

    Panuwet, Parinya; Hunter, Ronald E.; D’Souza, Priya E.; Chen, Xianyu; Radford, Samantha A.; Cohen, Jordan R.; Marder, M. Elizabeth; Kartavenka, Kostya; Ryan, P. Barry; Barr, Dana Boyd


    The ability to quantify levels of target analytes in biological samples accurately and precisely, in biomonitoring, involves the use of highly sensitive and selective instrumentation such as tandem mass spectrometers and a thorough understanding of highly variable matrix effects. Typically, matrix effects are caused by co-eluting matrix components that alter the ionization of target analytes as well as the chromatographic response of target analytes, leading to reduced or increased sensitivity of the analysis. Thus, before the desired accuracy and precision standards of laboratory data are achieved, these effects must be characterized and controlled. Here we present our review and observations of matrix effects encountered during the validation and implementation of tandem mass spectrometry-based analytical methods. We also provide systematic, comprehensive laboratory strategies needed to control challenges posed by matrix effects in order to ensure delivery of the most accurate data for biomonitoring studies assessing exposure to environmental toxicants. PMID:25562585

  13. Biological effects of high strength electric fields. Second interim progress report, September 1976--March 1977

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, R.D.; Kaune, W.T.


    This report describes progress made on the Project during the period of September 9, 1976 to March 31, 1977 towards the determination of the biological effects of high strength electric fields on small laboratory animals. The efforts to date can be divided into five categories: (1) the design, construction, and testing of a prototype and special studies exposure system; (2) the design and construction of exposure systems for rats and mice; (3) dosimetry; (4) experiments to determine the maximum field strength which does not produce corona discharge, ozone formation, shocks to the animal, hair stimulation, or a behavioral preference by rats to avoid exposure to the field; and (5) preparations for the biological screening experiments.

  14. Cellular burdens and biological effects on tissue level caused by inhaled radon progenies

    CERN Document Server

    Madas, Balázs G; Farkas, Árpád; Szőke, István


    In the case of radon exposure, the spatial distribution of deposited radioactive particles is highly inhomogeneous in the central airways. The objective of this research is to investigate the consequences of this heterogeneity regarding cellular burdens in the bronchial epithelium and to study the possible biological effects on tissue level. Applying a computational fluid dynamics program, the deposition distribution of inhaled radon daughters has been determined in a bronchial airway model for 23 minutes of work in the New Mexico uranium mine corresponding to 0.0129 WLM exposure. A numerical epithelium model based on experimental data has been utilized in order to quantify cellular hits and doses. Finally, a carcinogenesis model considering cell death induced cell cycle shortening has been applied to assess the biological responses. Computations present, that cellular dose may reach 1.5 Gy, which is several orders of magnitude higher than tissue dose. The results are in agreement with the histological findin...

  15. Across the Great Divide: The Effects of Technology in Secondary Biology Classrooms (United States)

    Worley, Johnny Howard, II

    This study investigates the relationship between technology use and student achievement in public high school across North Carolina. The purpose of this study was to determine whether a digital divide (differences in technology utilization based on student demographics of race/ethnicity, gender, socioeconomic status, and municipality) exists among schools and whether those differences relate to student achievement in high school biology classrooms. The study uses North Carolina end-of-course (EOC) data for biology to analyze student demographic data and assessment results from the 2010-2011 school year from the North Carolina Department of Public Instruction. The data analyses use descriptive and factorial univariate statistics to determine the existence of digital divides and their effects on biology achievement. Analysis of these data described patterns of technology use to determine whether potential variances resulted in a digital divide. Specific technology uses were identified in the data and then their impact on biology achievement scores within various demographic groups was examined. Research findings revealed statistically significant variations of use within different population groups. Despite being statistically significant, the relevance of the association in the variations was minimal at best -- based on the effect scale established by Cohen (1988). Additional factorial univariate analyses were employed to determine potential relationships between technology use and student achievement. The data revealed that technology use did not influence the variation of student achievement scale scores as much as race/ethnicity and socioeconomic status. White students outperformed Hispanic students by an average of three scale score points and Black students by an average of six scale score points. Technology use alone averaged less than a one point difference in mean scale scores, and only when interacting with race, gender, and/or SES did the mean difference

  16. RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCα signaling pathway

    Directory of Open Access Journals (Sweden)

    Loïc Maillard


    Full Text Available The perpetuation of angiogenesis is involved in certain chronic inflammatory diseases. The accelerated neovascularisation may result from an inflammatory status with a response of both endothelial cells and monocytes to inflammatory mediators such as chemokines. We have previously described in vitro and in vivo the pro-angiogenic effects of the chemokine Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES/CCL5. The effects of RANTES/CCL5 may be related to its binding to G protein-coupled receptors and to proteoglycans such as syndecan-1 and -4. The aim of this study was to evaluate the functionality of syndecan-4 as a co-receptor of RANTES/CCL5 by the use of mutated syndecan-4 constructs. Our data demonstrate that site-directed mutations in syndecan-4 modify RANTES/CCL5 biological activities in endothelial cells. The SDC4S179A mutant, associated with an induced protein kinase C (PKCα activation, leads to higher RANTES/CCL5 pro-angiogenic effects, whereas the SDC4L188QQ and the SDC4A198del mutants, leading to lower phosphatidylinositol 4,5-bisphosphate (PIP2 binding or to lower PDZ protein binding respectively, are associated with reduced RANTES/CCL5 cellular effects. Moreover, our data highlight that the intracellular domain of SDC-4 is involved in RANTES/CCL5-induced activation of the PKCα signaling pathway and biological effect. As RANTES/CCL5 is involved in various physiopathological processes, the development of a new therapeutic strategy may be reliant on the mechanism by which RANTES/CCL5 exerts its biological activities, for example by targeting the binding of the chemokine to its proteoglycan receptor.

  17. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness. (United States)

    Blakely, E A; Kronenberg, A


    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  18. Heavy-ion radiobiology: new approaches to delineate mechanisms underlying enhanced biological effectiveness (United States)

    Blakely, E. A.; Kronenberg, A.; Chatterjee, A. (Principal Investigator)


    Shortly after the discovery of polonium and radium by Marie Curie and her husband and colleague, Pierre Curie, it was learned that exposure to these alpha-particle emitters produced deleterious biological effects. The mechanisms underlying the increased biological effectiveness of densely ionizing radiations, including alpha particles, neutrons and highly energetic heavy charged particles, remain an active area of investigation. In this paper, we review recent advances in several areas of the radiobiology of these densely ionizing radiations, also known as heavy ions. Advances are described in the areas of DNA damage and repair, chromosome aberrations, mutagenesis, neoplastic transformation in vitro, genomic instability, normal tissue radiobiology and carcinogenesis in vivo. We focus on technical innovations, including novel applications of pulsed-field gel electrophoresis, fluorescence in situ hybridization (FISH), linkage analysis, and studies of gene expression and protein expression. We also highlight the use of new cellular and animal systems, including those with defined DNA repair deficiencies, as well as epithelial cell model systems to assess neoplastic transformation both in vitro and in vivo. The studies reviewed herein have had a substantial impact on our understanding of the genotoxic effects of heavy ions as well as their distinct effects on tissue homeostasis. The use of these radiations in cancer therapy is also discussed. The use of both heavy-ion and proton therapy is on the upswing in several centers around the world, due to their unique energy deposition characteristics that enhance the therapeutic effect and help reduce damage to normal tissue.

  19. Leishmania tropica: the effect of darkness and light on biological activities in vitro. (United States)

    Allahverdiyev, Adil M; Koc, Rabia Cakir; Ates, Sezen Canim; Bagirova, Malahat; Elcicek, Serhat; Oztel, Olga Nehir


    Leishmania parasites can be exposed to effects of light in their vectors and hosts, at various periods. However, there is no information about the effects of light on Leishmania parasites. The aim of this study is to investigate the effects of light on various cell parameters of Leishmania tropica, in vitro. All experiments were conducted on L. tropica promastigotes and amastigote-macrophage cultures, using flow cytometric analysis, MTT and phenol-sulfuric acid assay, DAPI and Giemsa. The results showed that the morphology of parasites has changed; the cell cycle has been affected and this caused parasites to remain at G0/G1 phase. Furthermore the proliferation, infectivity, glucose consumption and mitochondrial dehydrogenase activities of parasites were decreased. Thus, for the first time, in this study, the effects of light on biological activities of Leishmania parasites were shown. These new information about parasites' biology, would be very important to investigate the effects of light on the parasites in infected vectors and hosts.

  20. Track Structure and the Biological Effectiveness of Accelerated Particles for the Induction of Chromosome Damage (United States)

    George, K.; Hada, M.; Chappell, L.; Cucinotta, F. A.


    Track structure models predict that at a fixed value of LET, particles with lower charge number, Z will have a higher biological effectiveness compared to particles with a higher Z. In this report we investigated how track structure effects induction of chromosomal aberration in human cells. Human lymphocytes were irradiated in vitro with various energies of accelerated iron, silicon, neon, or titanium ions and chromosome damage was assessed in using three color FISH chromosome painting in chemically induced PCC samples collected a first cell division post irradiation. The LET values for these ions ranged from 30 to195 keV/micron. Of the particles studied, Neon ions have the highest biological effectiveness for induction of total chromosome damage, which is consistent with track structure model predictions. For complex-type exchanges 64 MeV/ u Neon and 450 MeV/u Iron were equally effective and induced the most complex damage. In addition we present data on chromosomes exchanges induced by six different energies of protons (5 MeV/u to 2.5 GeV/u). The linear dose response term was similar for all energies of protons suggesting that the effect of the higher LET at low proton energies is balanced by the production of nuclear secondaries from the high energy protons.

  1. Effect of capping agents: Structural, optical and biological properties of ZnO nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Javed, Rabia [Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Usman, Muhammad, E-mail: [Department of Physics, Faculty of Natural Sciences, Quaid-i-Azam University, Islamabad 45320 (Pakistan); Department of Physics, School of Science and Engineering, Lahore University of Management Sciences, Lahore 54729 (Pakistan); Tabassum, Saira; Zia, Muhammad [Department of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320 (Pakistan)


    Highlights: • ZnO nanoparticles have been effectively capped with polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) shown by the data of XRD, FTIR and UV–visible spectroscopy. • Reduction in size occurred from 34 nm to 26 nm due to capping agent and band gap energy increases with the decrease in the particle size. • Antibacterial activity against Gram-positive bacteria is greater than the Gram-negative bacteria. • All biological assays reveal highest activities in capped ZnO nanoparticles as compared to the uncapped ZnO nanoparticles. • Highest antibacterial activity has been exhibited by ZnO-PVP while highest antioxidant and antidiabetic activities have been conferred by ZnO- PEG. - Abstract: Different biological activities of capped and uncapped ZnO nanoparticles were investigated, and the effects of potential capping agents on these biological activities were studied. ZnO nanoparticles were synthesized and capped by polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) using a simple chemical method of co-precipitation. Characterization by X-ray diffraction (XRD), Fourier transform Infrared spectroscopy (FTIR) and UV–vis spectroscopy confirmed the crystallinity, size, functional group, and band gap of synthesized nanoparticles. Reduction in size occurred from 34 nm to 26 nm due to surfactant. Results of all biological activities indicated significantly higher values in capped as compared to uncapped nanoparticles. Antibacterial activity against Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC15224), and Acetobacter was obtained. This activity was more prominent against Gram-positive bacteria, and ZnO-PVP nanoparticles elucidated highest antibacterial activity (zone of inhibition 17 mm) against Gram-positive, Bacillus subtilis species. Antioxidant activities including total flavonoid content, total phenolic content, total antioxidant capacity, total reducing power and %age inhibition of DPPH, and

  2. Dynamic thermoelectricity in uniform bipolar semiconductor

    Energy Technology Data Exchange (ETDEWEB)

    Volovichev, I.N., E-mail:


    The theory of the dynamic thermoelectric effect has been developed. The effect lies in an electric current flowing in a closed circuit that consists of a uniform bipolar semiconductor, in which a non-uniform temperature distribution in the form of the traveling wave is created. The calculations are performed for the one-dimensional model in the quasi-neutrality approximation. It was shown that the direct thermoelectric current prevails, despite the periodicity of the thermal excitation, the circuit homogeneity and the lack of rectifier properties of the semiconductor system. Several physical reasons underlining the dynamic thermoelectric effect are found. One of them is similar to the Dember photoelectric effect, its contribution to the current flowing is determined by the difference in the electron and hole mobilities, and is completely independent of the carrier Seebeck coefficients. The dependence of the thermoelectric short circuit current magnitude on the semiconductor parameters, as well as on the temperature wave amplitude, length and velocity is studied. It is shown that the magnitude of the thermoelectric current is proportional to the square of the temperature wave amplitude. The dependence of the thermoelectric short circuit current on the temperature wave length and velocity is the nonmonotonic function. The optimum values for the temperature wave length and velocity, at which the dynamic thermoelectric effect is the greatest, have been deduced. It is found that the thermoelectric short circuit current changes its direction with decreasing the temperature wave length under certain conditions. The prospects for the possible applications of the dynamic thermoelectric effect are also discussed.

  3. Effect of non-uniform excitation on seismic response of long-distance water-conveyance tunnel%非一致激励下长距离输水隧道地震响应分析

    Institute of Scientific and Technical Information of China (English)

    禹海涛; 袁勇; 顾玉亮; 杨志豪


      Long tunnels suffered great damages in recent earthquakes frequently. With the increasing of large amount of water conveying engineering under construction, the seismic performance of long-distance water-conveying tunnels is significant. Based on the deficiency of traditional method for large-scale seismic computation,a large-scale analysis method is proposed to solve the non-uniform seismic response problems of the complex soil-long tunnel-water system. As an application,the presented method is used in an exist⁃ing long-distance water tunnel,which is one of the key projects in Shanghai. Both the nonlinear hysteretic constitutive model of soil and nonlinear contact behaviors between soil and tunnel are considered in the es⁃tablished numerical model. Furthermore,the added mass method is introduced to simplify the effect of dy⁃namic water pressure on the tunnel liner when subjected to seismic loadings. Two seismic input modes,the uniform and non-uniform excitations,are involved in the seismic analyses of the long water tunnel system. Compared with the uniform seismic input, the results show that the non-uniform excitation can remarkably increase both stress and deformation responses of the long tunnel, which makes adverse influence on the seismic performance of the tunnel. The research conclusions are beneficial to proving theoretical criterions for seismic design and analysis of long water-conveying tunnels.%  近年长隧道结构震害频发,随着调水工程大规模建设,长距离输水隧道抗震性能的重要性愈加突出。在隧道传统抗震分析方法的基础上,针对非一致地震动作用下地基土-长距离输水隧道体系的地震响应问题,建立了非一致激励下长距离输水隧道的大规模地震响应分析方法,并以上海市某重点工程中的长距离输水隧道为工程应用,计算模型中不仅考虑了土体的动力滞回非线性、土体与隧道之间的接触非线性等因素

  4. Effects of surface roughness on non-uniform phases of superfluid 3He and spin-triplet models for Sr2RuO4 (United States)

    Vorontsov, Anton; Sauls, James


    We present theoretical and computational results for the spectrum of surface bound states of confined superfluid 3He and spin-triplet, odd-parity pairing theories of Sr2RuO4. The surface states, despite being related to the topological structure of the condensed state, are sensitive to surface disorder. We investigate effects of surface roughness on the physical properties of the boundary layer of several coherence lengths. We find that for confined 3He-A or chiral phases proposed for Sr2RuO4 the spatial profile of the edge current is significantly modified for atomically rough surfaces compared to that for specular surfaces. The boundary effect is strongly reflected in the ground-state angular momentum generated by the edge states. In thin films of superfluid 3He with rough surfaces the effect of surface scattering is expected to be even more important since surface states dominate the thermodynamic properties. For specular boundaries we predicted new phases with spontaneously broken time-reversal or translational symmetries should appear in films of D ~ 10ξ0 . We report results for the phase diagram for specular, diffuse and maximal pair-breaking resulting from retro-reflecting boundaries. Supported by NSF Grants DMR-0954342 and DMR-1106315.

  5. 温场均匀性对CdTe薄膜及太阳电池性能的影响%Effect of the Uniformity of Temperature Field on the Properties of CdTe Films and Solar Cells

    Institute of Scientific and Technical Information of China (English)

    李愿杰; 郑家贵; 冯良桓; 黎兵; 曾广根


    The transformation of preparation temperature field of large area CdTe films was simulated, and the effect of temperature field' s uniformity on CdS/CdTe solar cells was investigated by the characteration of I -V,C -V and Deep Level Transient Spectroscopy(DLTS). The result showed that the uniformity of temperature field has effect on Isc and FF, but lacks impact on Voc. Least dark saturated current density,more higher carrier concentration and better photovoltaie performance were observed in the sample prepared at 580℃ ; The response of deep-level impuri-ties in CdTe films is consistent with temperature and frequency, but the sample(580 ℃) has less deep-level impu-rities' recombination because of lower hole trap concentration. 8.2% efficiency of the CdS/CdTe solar cells was reached by improved the uniformity of temperature field.%采用近空间升华法(CSS)制备CdTe多晶薄膜,模拟制备过程中的温场变化,结合,I-V、C-V特性及深能级瞬态谱研究温场均匀性对CdS/CdTe太阳电池性能的影响.结果表明,温场分布和薄膜厚度分布基本一致,温场均匀性对电池组件的开路电压影响不大,对短路电流和填充因子有影响,CdTe薄膜的深中心对温度和频率的响应基本一致.580℃制备的样品暗饱和电流密度最小,载流子浓度较高,光电特性较好,而且空穴陷阱浓度较低,深中心复合作用较小.通过改进温场的均匀性能够制备出组件转换效率为8.2%的CdS/CdTe太阳电池.

  6. The Effects of Using Concept Mapping for Improving Advanced Level Biology Students' Lower- and Higher-Order Cognitive Skills (United States)

    Bramwell-Lalor, Sharon; Rainford, Marcia


    This paper reports on teachers' use of concept mapping as an alternative assessment strategy in advanced level biology classes and its effects on students' cognitive skills on selected biology concepts. Using a mixed methods approach, the study employed a pre-test/post-test quasi-experimental design involving 156 students and 8 teachers from…

  7. Biological monitoring of non-thermal effects of mobile phone radiation: recent approaches and challenges. (United States)

    Gaestel, Matthias


    This review describes recent developments in analysing the influence of radio-frequency electromagnetic fields (RF-EMFs ) on biological systems by monitoring the cellular stress response as well as overall gene expression. Recent data on the initiation and modulation of the classical cellular stress response by RF-EMFs, comprising expression of heat shock proteins and stimulation of stress-activated protein kinases, are summarised and evaluated. Since isothermic RF-EMF exposure is assumed rather than proven there are clear limitations in using the stress response to describe non-thermal effects of RF-EMFs. In particular, further experiments are needed to characterise better the threshold of the thermal heat shock response and the homogeneity of the cellular response in the whole sample for each biological system used. Before then, it is proposed that the absence of the classical stress response can define isothermal experimental conditions and qualifies other biological effects of RF-EMFs detected under these conditions to be of non-thermal origin. To minimise the probability that by making this assumption valuable insights into the nature of biological effects of RF-EMFs could be lost, proteotoxic non-thermal RF-EMF effects should also be monitored by measuring activities of labile intracellular enzymes and/or levels of their metabolites before the threshold for the heat shock response is reached. In addition, non-thermal induction of the stress response via promoter elements distinct from the heat shock element (HSE) should be analysed using HSE-mutated heat shock promoter reporter constructs. Screening for non-thermal RF-EMF effects in the absence of a classical stress response should be performed by transcriptomics and proteomics. Recent approaches demonstrate that due to their high-throughput characteristics, these methods inherently generate false positive results and require statistical evaluation based on quantitative expression analysis from a sufficient

  8. Uniform and Non-Uniform Single Image Deblurring Based on Sparse Representation and Adaptive Dictionary Learning

    Directory of Open Access Journals (Sweden)

    Ashwini M. Deshpande


    Full Text Available Considering the sparseness property of images, a sparse representation based iterative deblurring method is presented for single image deblurring under uniform and non-uniform motion blur. The approach taken is based on sparse and redundant representations over adaptively training dictionaries from single blurred-noisy image itself. Further, the K-SVD algorithm is used to obtain a dictionary that describes the image contents effectively. Comprehensive experimental evaluation demonstrate that the proposed framework integrating the sparseness property of images, adaptive dictionary training and iterative deblurring scheme together significantly improves the deblurring performance and is comparable with the state-of-the art deblurring algorithms and seeks a powerful solution to an ill-conditioned inverse problem.

  9. Effective automated feature construction and selection for classification of biological sequences.

    Directory of Open Access Journals (Sweden)

    Uday Kamath

    Full Text Available Many open problems in bioinformatics involve elucidating underlying functional signals in biological sequences. DNA sequences, in particular, are characterized by rich architectures in which functional signals are increasingly found to combine local and distal interactions at the nucleotide level. Problems of interest include detection of regulatory regions, splice sites, exons, hypersensitive sites, and more. These problems naturally lend themselves to formulation as classification problems in machine learning. When classification is based on features extracted from the sequences under investigation, success is critically dependent on the chosen set of features.We present an algorithmic framework (EFFECT for automated detection of functional signals in biological sequences. We focus here on classification problems involving DNA sequences which state-of-the-art work in machine learning shows to be challenging and involve complex combinations of local and distal features. EFFECT uses a two-stage process to first construct a set of candidate sequence-based features and then select a most effective subset for the classification task at hand. Both stages make heavy use of evolutionary algorithms to efficiently guide the search towards informative features capable of discriminating between sequences that contain a particular functional signal and those that do not.To demonstrate its generality, EFFECT is applied to three separate problems of importance in DNA research: the recognition of hypersensitive sites, splice sites, and ALU sites. Comparisons with state-of-the-art algorithms show that the framework is both general and powerful. In addition, a detailed analysis of the constructed features shows that they contain valuable biological information about DNA architecture, allowing biologists and other researchers to directly inspect the features and potentially use the insights obtained to assist wet-laboratory studies on retainment or modification

  10. Combined exposures: an update from the International Commission on Biological Effects of Noise. (United States)

    Leroux, Tony; Klaeboe, Ronny


    International Commission on Biological Effects of Noise (ICBEN) Team 8 deals with the effects of combined "agents" in the urban and work place settings. Results presented at the ICBEN conference indicate that some pesticides, more specifically the organophosphates, and a wider range of industrial chemicals are harmful to the auditory system at concentrations often found in occupational settings. Effects of occupational noise on hearing are exacerbated by toluene and possibly by carbon monoxide. Several of the chemicals studied found to be potentially toxic not only to hair cells in the cochlea but also to the auditory nerve. In urban environments, team 8 focuses on additive and synergetic effects of ambient stressors. It was argued that noise policies need to pay attention to grey areas with intermediate noise levels. Noteworthy is also stronger reactions to vibrations experienced in the evening and during the night. An innovative event-based model for sound perception was presented.

  11. Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints (United States)

    Cacao, Eliedonna; Hada, Megumi; Saganti, Premkumar B.; George, Kerry A.; Cucinotta, Francis A.


    The biological effects of high charge and energy (HZE) particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies that makeup primary or secondary radiation in HZE particle exposures precludes tumor induction studies in animal models for all but a few particle types and energies, thus leading to the use of surrogate endpoints to investigate the details of the radiation quality dependence of relative biological effectiveness (RBE) factors. In this report we make detailed RBE predictions of the charge number and energy dependence of RBE’s using a parametric track structure model to represent experimental results for the low dose response for chromosomal exchanges in normal human lymphocyte and fibroblast cells with comparison to published data for neoplastic transformation and gene mutation. RBE’s are evaluated against acute doses of γ-rays for doses near 1 Gy. Models that assume linear or non-targeted effects at low dose are considered. Modest values of RBE (10) are predicted at low doses <0.1 Gy. The radiation quality dependence of RBE’s against the effects of acute doses γ-rays found for neoplastic transformation and gene mutation studies are similar to those found for simple exchanges if a linear response is assumed at low HZE particle doses. Comparisons of the resulting model parameters to those used in the NASA radiation quality factor function are discussed. PMID:27111667

  12. Relative Biological Effectiveness of HZE Particles for Chromosomal Exchanges and Other Surrogate Cancer Risk Endpoints.

    Directory of Open Access Journals (Sweden)

    Eliedonna Cacao

    Full Text Available The biological effects of high charge and energy (HZE particle exposures are of interest in space radiation protection of astronauts and cosmonauts, and estimating secondary cancer risks for patients undergoing Hadron therapy for primary cancers. The large number of particles types and energies that makeup primary or secondary radiation in HZE particle exposures precludes tumor induction studies in animal models for all but a few particle types and energies, thus leading to the use of surrogate endpoints to investigate the details of the radiation quality dependence of relative biological effectiveness (RBE factors. In this report we make detailed RBE predictions of the charge number and energy dependence of RBE's using a parametric track structure model to represent experimental results for the low dose response for chromosomal exchanges in normal human lymphocyte and fibroblast cells with comparison to published data for neoplastic transformation and gene mutation. RBE's are evaluated against acute doses of γ-rays for doses near 1 Gy. Models that assume linear or non-targeted effects at low dose are considered. Modest values of RBE (10 are predicted at low doses <0.1 Gy. The radiation quality dependence of RBE's against the effects of acute doses γ-rays found for neoplastic transformation and gene mutation studies are similar to those found for simple exchanges if a linear response is assumed at low HZE particle doses. Comparisons of the resulting model parameters to those used in the NASA radiation quality factor function are discussed.

  13. Assessment of the biological effects of 'strange' radiation

    Energy Technology Data Exchange (ETDEWEB)

    Pryakhin, E.A.; Tryapitsina, G.A. [Chelyabinsk State University, Chelyabinsk (Russian Federation); Urutskoyev, L.I. [RECOM Company, Kurchatov Russian Research Institute, Moscow (Russian Federation); Akleyev, A.V. [Urals Research Center for Radiation Medicine, Chelyabinsk (Russian Federation)


    The results from studies of the effects produced by electrical explosions of foils made from super pure materials in water point to the emergence of new chemical elements. An additional finding was the discharge of 'strange' radiation accompanying the transformation of chemical elements. However, currently, the mechanism involved in the interaction between 'strange' radiation and a substance or a biological entity remains obscure. Therefore, the aim of the present research is to investigate the biological effects of the 'strange' radiation. Pilot studies were performed at the RECOM RRC 'Kurchatov Institute' in April-May of 2004. The animals used in the experiment were female mice of C57Bl/6 line aged 80 days with body weight 16-18 g. The animals were exposed to radiation discharged during explosions of Ti foils in water and aqueous solutions. The cages with animals were placed at 1 m from the epicenter of the explosion. Explosions were carried out on the 19. (3 explosions), 20. (4 explosions) and 22. (3 explosions) of April, 2004 (explosions No1373 - No1382, respectively). The animals were assigned to 4 experimental groups comprised of 17-20 mice per group. The animals received experimental exposure within 1, 2 and 3 days of the experiment. In total, the experimental groups were exposed to 3, 7 and 10 explosions, respectively. In order to identify the biological reactions, the following parameters were estimated: number of nucleated cells in the bone marrow, number of CFU in the spleen after additional gamma-irradiation (6 Gy), cell composition of the bone marrow, the rate of erythrocytes with the different level of maturation in the bone marrow, the rate of erythrocytes with the micronuclei in the bone marrow, the reaction of bone marrow cells to additional gamma-irradiation (2 Gy), number of leucocytes in the peripheral blood, and cell composition of the peripheral blood. The following conclusions were drawn from these

  14. The effect of teaching methods on cognitive achievement, retention, and attitude among in biology studying

    Directory of Open Access Journals (Sweden)

    Snezana Stavrova Veselinovskaa


    Full Text Available The purpose of this paper is to determine the effects of usage of sequential teaching method on the academic achievement and retention level of students. Three student groups of biology students in University “Goce Delcev”, Faculty of Natural and Technical Sciences, Institute of Biology, - Stip, R. Macedonia were offered a topic on general characteristics of Proteins: Their Biological Functions and Primary Structure with different sequences of 3 teaching methods. The teaching methods were Laboratory method (student experiment, slide demonstration and lecture method. The first group started to course with experiments in the laboratory, then the relevant theory of proteins was given lecture method, and then the slides was shown (Group I. The sequence of these three teaching methods used in the first group was changed in both second and third group as follow: The lecture methods, slide show and experiment in Group II, and slide show, experiment and lecture method in Group III, respectively. Laboratory method used in the study was focused on the topic of this diversity and abundance reflect the central role of proteins in virtually all aspects of cell structure and function. Achievement test contained 20 questions, testing the knowledge of facts as well as the ability to transfer the knowledge and problem solving ability. This test was used as pre-test before methods’ application, post-test after the methods’ application and retention test after 30 days from methods’ applied.

  15. Leukemia, an effective model for chemical biology and target therapy1

    Institute of Scientific and Technical Information of China (English)

    Guo-qiang CHEN; Li-shun WANG; Ying-li WU; Yun YU


    The rapid rise of chemical biology aimed at studying signaling networks for basic cellular activities using specific, active small molecules as probes has greatly accelerated research on pathological mechanisms and target therapy of diseases.This research is especially important for malignant tumors such as leukemia, a heterogeneous group of hematopoietic malignancies that occurs worldwide. With the use of a chemical approach combined with genetic manipulation, great progresshas been achieved over the past few decades on the biological, molecular and cytogenetic aspects of leukemia, and in its diagnosis and therapy. In particular,discoveries of the clinical effectiveness of all-trans rctinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia and the kinase inhibitorsImatinib and Dasatinib in the treatment of chronic myelogenous leukemia not only make target therapy of leukemia a reality, but also push mechanisms of leukemo-genesis and leukemic cell activities forward. This review will outline advances in chemical biology that help our understanding of the molecular mechanisms of cell differentiation and apoptosis induction and target therapy of leukemia.

  16. Protective Effect of Selected Medicinal Plants against Hydrogen Peroxide Induced Oxidative Damage on Biological Substrates

    Directory of Open Access Journals (Sweden)

    Namratha Pai Kotebagilu


    Full Text Available Oxidative stress is developed due to susceptibility of biological substrates to oxidation by generation of free radicals. In degenerative diseases, oxidative stress level can be reduced by antioxidants which neutralize free radicals. Primary objective of this work was to screen four medicinal plants, namely, Andrographis paniculata, Costus speciosus, Canthium parviflorum, and Abrus precatorius, for their antioxidant property using two biological substrates—RBC and microsomes. The antioxidative ability of three solvent extracts, methanol (100% and 80% and aqueous leaf extracts, was studied at different concentrations by thiobarbituric acid reactive substances method using Fenton’s reagent to induce oxidation in the substrates. The polyphenol and flavonoid content were analyzed to relate with the observed antioxidant effect of the extracts. The phytochemical screening indicated the presence of flavonoids, polyphenols, tannins, and β-carotene in the samples. In microsomes, 80% methanol extract of Canthium and Costus and, in RBC, 80% methanol extract of Costus showed highest inhibition of oxidation and correlated well with the polyphenol and flavonoid content. From the results it can be concluded that antioxidants from medicinal plants are capable of inhibiting oxidation in biological systems, suggesting scope for their use as nutraceuticals.

  17. Effect of capping agents: Structural, optical and biological properties of ZnO nanoparticles (United States)

    Javed, Rabia; Usman, Muhammad; Tabassum, Saira; Zia, Muhammad


    Different biological activities of capped and uncapped ZnO nanoparticles were investigated, and the effects of potential capping agents on these biological activities were studied. ZnO nanoparticles were synthesized and capped by polyethylene glycol (PEG) and polyvinyl pyrrolidone (PVP) using a simple chemical method of co-precipitation. Characterization by X-ray diffraction (XRD), Fourier transform Infrared spectroscopy (FTIR) and UV-vis spectroscopy confirmed the crystallinity, size, functional group, and band gap of synthesized nanoparticles. Reduction in size occurred from 34 nm to 26 nm due to surfactant. Results of all biological activities indicated significantly higher values in capped as compared to uncapped nanoparticles. Antibacterial activity against Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC15224), and Acetobacter was obtained. This activity was more prominent against Gram-positive bacteria, and ZnO-PVP nanoparticles elucidated highest antibacterial activity (zone of inhibition 17 mm) against Gram-positive, Bacillus subtilis species. Antioxidant activities including total flavonoid content, total phenolic content, total antioxidant capacity, total reducing power and %age inhibition of DPPH, and antidiabetic activity against α-amylase enzyme found to be exhibited highest by ZnO-PEG nanoparticles.

  18. A Uniform Analysis of the Lyα Forest at z=0-5. II. Measuring the Mean Intensity of the Extragalactic Ionizing Background Using the Proximity Effect (United States)

    Scott, Jennifer; Bechtold, Jill; Dobrzycki, Adam; Kulkarni, Varsha P.


    Moderate-resolution data for 40 quasi-stellar objects (QSOs) at z~2 were combined with spectra of comparable resolution of 59 QSOs with redshifts greater than 1.7 found in the literature to form a large, homogeneous sample of moderate-resolution (~1 Å) QSO spectra. These spectra were presented and the statistics of the Lyα forest were discussed in Paper I. In this analysis, we demonstrate that a proximity effect is present in the data; i.e., there exists a significant (5.5 σ) deficit of lines at zabs~zem. Within 1.5 h-1 Mpc of the QSO emission redshift, the significance does depend on QSO luminosity, in accordance with the theory that this effect is caused by enhanced ionization of hydrogen in the vicinity of the QSO from UV photons from the QSO itself. The photoionization model of Bajtlik, Duncan, & Ostriker permits an estimate of the mean intensity of the extragalactic background radiation at the Lyman limit. We compare the results of this standard analysis with those obtained using a maximum likelihood technique. If the spectrum of the background is assumed to be identical to that of each individual QSO, and if this background is assumed to be constant over the redshift range 1.7

  19. Sources of Emittance in RF Photocathode Injectors: Intrinsic emittance, space charge forces due to non-uniformities, RF and solenoid effects

    CERN Document Server

    Dowell, David H


    Advances in electron beam technology have made possible the current generation of x-ray free electron lasers and electron microscopes. These devices have become valuable tools for basic research and applied science. An important technology related to xfels is the photocathode RF gun and injector. The invention of the RF gun and the developments of emittance compensation and beam matching were driving forces behind these new technologies. Achieving even brighter beams requires taking a finer resolution view of the electron dynamics near the cathode during emission and initial acceleration. In addition the bright beam is sensitive to optical aberrations in the injector's RF and magnetic lenses. This paper discusses these topics including beam properties due to cathode material properties, space charge effects close to the cathode and optical distortions of the RF and solenoid fields. Analytic relations for these phenomena are derived and compared with numerical simulations.

  20. Uniformly accelerated observer in a thermal bath

    CERN Document Server

    Kolekar, Sanved


    We investigate the quantum field aspects in flat spacetime for an uniformly accelerated observer moving in a thermal bath. In particular, we obtain an exact closed expression of the reduced density matrix for an uniformly accelerated observer with acceleration $a = 2\\pi T$ when the state of the quantum field is a thermal bath at temperature $T^\\prime$. We find that the density matrix has a simple form with an effective partition function $Z$ being a product, $Z = Z_T Z_{T^\\prime}$, of two thermal partition functions corresponding to temperatures $T$ and $T^\\prime$ and hence is not thermal, even when $T = T^\\prime$. We show that, even though the partition function has a product structure, the two thermal baths are, in fact, interacting systems; although in the high frequency limit $\\omega_k \\gg T$ and $\\omega_k \\gg T^\\prime$, the interactions are found to become sub-dominant. We further demonstrate that the resulting spectrum of the Rindler particles can be interpreted in terms of spontaneous and stimulated em...