WorldWideScience

Sample records for biological services research

  1. Report of the work of the Biological and Medical Research, Radiological Physics, and Health Services Divisions for the quarterly period ending September 30, 1953.

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1953-10-01

    The monthly progress report from the Argonne National Laboratory includes material from one-third of the Laboratory. The three divisions into which the work has been divided are: (l) Reactor Engineering, Physics, Instrument Research and Development, and Electronics, (2) Biological and Medical Research, Radiological Physics, and Health Services, and (3) Chemistry and Chemical Engineering, Metallurgy, and Remote Control Engineering. The present monthly progress report covers the work in Biological and Medical Research, Radiological Physics, and Health Services for the quarterly period ending September 30, 1953.

  2. History of the Chemical Warfare Service in World War II. Biological Warfare Research in the United States, Volume 2

    Science.gov (United States)

    1947-11-01

    263 Pathogenicity 266 Defensive Research 269 IX BRUCELLOSIS 276 General 276 Selection of Strain 277 Simulant.. m ^ -78 Nutrition ; 2S0...Safety Precautions *. sg^, Production of Inactivated Bovine Tissue Vaccines... 362 Production of Inactivated Egg-Cultivated Virus 365...Serrisc M » C •« e li t\\ a .. 0LU21L. liar Research Service Project # 3 Subject for Research: Brucellosis (Code "US") Location

  3. Including a Service Learning Educational Research Project in a Biology Course-II: Assessing Community Awareness of Legionnaires' Disease?

    Science.gov (United States)

    Abu-Shakra, Amal

    2012-01-01

    For a university service learning educational research project addressing Legionnaires' disease (LD), a Yes/No questionnaire on community awareness of LD was developed and distributed in an urban community in North Carolina, USA. The 456 questionnaires completed by the participants were sorted into yes and no sets based on responses obtained to…

  4. Tumor Biology and Microenvironment Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research in this area seeks to understand the role of tumor cells and the tumor microenvironment (TME) in driving cancer initiation, progression, maintenance and recurrence.

  5. Biological Defense Research Program

    Science.gov (United States)

    1989-04-01

    Intraperitoneal infectious Dose HEPA High-Efficiency Particle Arresting (filter) HHS US Department of Health and Human Services HID Human Infectious Dose HIV ...as botulinum toxin and snake venom toxins, as well as toxins that affect nerve ion channels. Small animals (rats, mice) and cultured cell lines are...The BDRP has been an ongoing program for a number of years, and, as such, has bee : subject to continuous internal and external review processes to

  6. Including a Service Learning Educational Research Project in a Biology Course-I: Assessing Community Awareness of Childhood Lead Poisoning

    Science.gov (United States)

    Abu-Shakra, Amal; Saliim, Eric

    2012-01-01

    A university course project was developed and implemented in a biology course, focusing on environmental problems, to assess community awareness of childhood lead poisoning. A set of 385 questionnaires was generated and distributed in an urban community in North Carolina, USA. The completed questionnaires were sorted first into yes and no sets…

  7. Including a service learning educational research project in a biology course-I: Assessing community awareness of childhood lead poisoning

    OpenAIRE

    Abu-Shakra, Amal; Saliim, Eric

    2012-01-01

    A university course project was developed and implemented in a biology course, focusing on environmental problems, to assess community awareness of childhood lead poisoning. A set of 385 questionnaires was generated and distributed in an urban community in North Carolina, USA. The completed questionnaires were sorted fırst into yes and no sets based on the responses obtained for the fırst question, which gauged the participants' awareness of lead as an indoor pollutant at 71% (n=273)...

  8. Advancing vector biology research

    NARCIS (Netherlands)

    Kohl, Alain; Pondeville, Emilie; Schnettler, Esther; Crisanti, Andrea; Supparo, Clelia; Christophides, George K.; Kersey, Paul J.; Maslen, Gareth L.; Takken, Willem; Koenraadt, Constantianus J.M.; Oliva, Clelia F.; Busquets, Núria; Abad, F.X.; Failloux, Anna Bella; Levashina, Elena A.; Wilson, Anthony J.; Veronesi, Eva; Pichard, Maëlle; Arnaud Marsh, Sarah; Simard, Frédéric; Vernick, Kenneth D.

    2016-01-01

    Vector-borne pathogens impact public health, animal production, and animal welfare. Research on arthropod vectors such as mosquitoes, ticks, sandflies, and midges which transmit pathogens to humans and economically important animals is crucial for development of new control measures that target

  9. Biological Web Service Repositories Review.

    Science.gov (United States)

    Urdidiales-Nieto, David; Navas-Delgado, Ismael; Aldana-Montes, José F

    2017-05-01

    Web services play a key role in bioinformatics enabling the integration of database access and analysis of algorithms. However, Web service repositories do not usually publish information on the changes made to their registered Web services. Dynamism is directly related to the changes in the repositories (services registered or unregistered) and at service level (annotation changes). Thus, users, software clients or workflow based approaches lack enough relevant information to decide when they should review or re-execute a Web service or workflow to get updated or improved results. The dynamism of the repository could be a measure for workflow developers to re-check service availability and annotation changes in the services of interest to them. This paper presents a review on the most well-known Web service repositories in the life sciences including an analysis of their dynamism. Freshness is introduced in this paper, and has been used as the measure for the dynamism of these repositories. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  10. Evolutionary Biology Research in India

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 10. Evolutionary Biology Research in India. Information and Announcements Volume 5 Issue 10 October 2000 pp 102-104. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/005/10/0102-0104 ...

  11. Evolutionary Biology Research in India

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 10. Evolutionary Biology Research in India. Information and Announcements Volume 5 Issue 10 October 2000 pp 102-104. Fulltext. Click here to view fulltext PDF. Permanent link: https://www.ias.ac.in/article/fulltext/reso/005/10/0102-0104 ...

  12. Cancer research meets evolutionary biology.

    Science.gov (United States)

    Pepper, John W; Scott Findlay, C; Kassen, Rees; Spencer, Sabrina L; Maley, Carlo C

    2009-02-01

    There is increasing evidence that Darwin's theory of evolution by natural selection provides insights into the etiology and treatment of cancer. On a microscopic scale, neoplastic cells meet the conditions for evolution by Darwinian selection: cell reproduction with heritable variability that affects cell survival and replication. This suggests that, like other areas of biological and biomedical research, Darwinian theory can provide a general framework for understanding many aspects of cancer, including problems of great clinical importance. With the availability of raw molecular data increasing rapidly, this theory may provide guidance in translating data into understanding and progress. Several conceptual and analytical tools from evolutionary biology can be applied to cancer biology. Two clinical problems may benefit most from the application of Darwinian theory: neoplastic progression and acquired therapeutic resistance. The Darwinian theory of cancer has especially profound implications for drug development, both in terms of explaining past difficulties, and pointing the way toward new approaches. Because cancer involves complex evolutionary processes, research should incorporate both tractable (simplified) experimental systems, and also longitudinal observational studies of the evolutionary dynamics of cancer in laboratory animals and in human patients. Cancer biology will require new tools to control the evolution of neoplastic cells.

  13. Development trend of radiation biology research-systems radiation biology

    International Nuclear Information System (INIS)

    Min Rui

    2010-01-01

    Radiation biology research has past 80 years. We have known much more about fundamentals, processes and results of biology effects induced by radiation and various factors that influence biology effects wide and deep, however many old and new scientific problems occurring in the field of radiation biology research remain to be illustrated. To explore and figure these scientific problems need systemic concept, methods and multi dimension view on the base of considerations of complexity of biology system, diversity of biology response, temporal and spatial process of biological effects during occurrence, and complex feed back network of biological regulations. (authors)

  14. Review of domestic radiation biology research

    International Nuclear Information System (INIS)

    Zheng Chun; Song Lingli; Ai Zihui

    2011-01-01

    Radiation biology research in China during the past ten years are reviewed. It should be noticed that radiation-biology should focus on microdosimetry, microbeam application, and radiation biological mechanism. (authors)

  15. Space Station Biological Research Project

    Science.gov (United States)

    Johnson, Catherine C.; Hargens, Alan R.; Wade, Charles E.

    1995-01-01

    NASA Ames Research Center is responsible for the development of the Space Station Biological Research Project (SSBRP) which will support non-human life sciences research on the International Space Station Alpha (ISSA). The SSBRP is designed to support both basic research to understand the effect of altered gravity fields on biological systems and applied research to investigate the effects of space flight on biological systems. The SSBRP will provide the necessary habitats to support avian and reptile eggs, cells and tissues, plants and rodents. In addition a habitat to support aquatic specimens will be provided by our international partners. Habitats will be mounted in ISSA compatible racks at u-g and will also be mounted on a 2.5 m diameter centrifuge except for the egg incubator which has an internal centrifuge. The 2.5 m centrifuge will provide artificial gravity levels over the range of 0.01 G to 2 G. The current schedule is to launch the first rack in 1999, the Life Sciences glovebox and a second rack early in 2001, a 4 habitat 2.5 in centrifuge later the same year in its own module, and to upgrade the centrifuge to 8 habitats in 2004. The rodent habitats will be derived from the Advanced Animal Habitat currently under development for the Shuttle program and will be capable of housing either rats or mice individually or in groups (6 rats/group and at least 12 mice/group). The egg incubator will be an upgraded Avian Development Facility also developed for the Shuttle program through a Small Business and Innovative Research grant. The Space Tissue Loss cell culture apparatus, developed by Walter Reed Army Institute of Research, is being considered for the cell and tissue culture habitat. The Life Sciences Glovebox is crucial to all life sciences experiments for specimen manipulation and performance of science procedures. It will provide two levels of containment between the work volume and the crew through the use of seals and negative pressure. The glovebox

  16. Biological Research for Radiation Protection

    International Nuclear Information System (INIS)

    Kim, In Gyu; Kim, Kug Chan; Jung, Il Lae; Choi, Yong Ho; Kim, Jin Sik; Moon, Myung Sook; Byun, Hee Sun; Phyo, Ki Heon; Kim, Sung Keun

    2005-04-01

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H 2 O 2 (toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H 2 O 2 )-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H 2 O 2 (or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell protecting effects. Based on the above result, we suggest that the express regulation of theses genes have potentially importance for sensitizing the efficiency of radiation therapy of cancer or for protecting the radiation-induced damage of normal cells

  17. Biological Research for Radiation Protection

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Gyu; Kim, Kug Chan; Jung, Il Lae; Choi, Yong Ho; Kim, Jin Sik; Moon, Myung Sook; Byun, Hee Sun; Phyo, Ki Heon; Kim, Sung Keun

    2005-04-15

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about ornithine decarboxylase and its controlling proteins, thioredoxin, peroxiredoxin, S-adenosymethionine decarboxylase, and glutamate decarboxylase 67KD effect on the cell death triggered ionizing radiation and H{sub 2}O{sub 2}(toxic agents). In this study, to elucidate the role of these proteins in the ionizing radiation (or H{sub 2}O{sub 2})-induced apoptotic cell death, we utilized sensesed (or antisensed) cells, which overexpress (or down-regulate) RNAs associated with these proteins biosynthesis, and investigated the effects of these genes on the cytotoxicity caused by ionizing radiation and H{sub 2}O{sub 2}(or paraquat). We also investigated whether genisteine(or thiamine) may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation (may enhance the preventing effect radiation or paraquat-induced damage) because such compounds are able to potentiate the cell-killing or cell protecting effects. Based on the above result, we suggest that the express regulation of theses genes have potentially importance for sensitizing the efficiency of radiation therapy of cancer or for protecting the radiation-induced damage of normal cells.

  18. Biological research for radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Gyu; Kim, Kug Chan; Shim, Hae Won; Oh, Tae Jeong; Park, Seon Young; Lee, Kang Suk

    2000-04-01

    The work scope of Biological research for the radiation protection had contained the search of biological microanalytic methods for assessing the health effect by {gamma}-radiation and toxic agents, the standardization of human T-lymphocyte cell culture and polymerase chain reaction, T-cell clonal assay, and the quantification of mutation frequency in the hypoxanthine (guanine) phosphoribosyl transferase (HPRT) gene locus by single exposure or combined exposure. Especially, the polymerase chain reaction methods using reverse transcriptase has been developed to analyze the mutant gene induced by {gamma}-radiation and chemical (pentachlorophenol) agent exposure, and to investigate the point mutations in the HPRT gene locus of T-lymphocytes. The HPRT T-cell clonal assay revealed that it could not differentiate {gamma}-irradiation from pentachlorophenol, because the frequency of somatic mutations induced by both damaging agents increased in a dose-dependent manner. The analysis of DNA sequence alterations of HPRT mutant clones clearly showed that both damaging agents induced different mutational spectra in the HPRT locus of T-cells. The large deletions, which account for 75 percent of the analyzed mutants, are characteristic mutations induced by {gamma}-irradiation. By contrast, point mutations such as base substitutions and insertion, come up to 97 percent in the case of pentachlorophenol-treated cells. The point mutation frequencies at 190 base pair and 444 base pair positions are 3-6 folds as high as in those at other mutation positions. It may be that these mutation sites are hot spots induced by pentachlorophenol. These results suggest that the HPRT mutation spectrum can be used as a potential bio marker for assessing a specific environmental risk. (author)

  19. Center for Biologics Evaluation and Research (CBER)

    Data.gov (United States)

    Federal Laboratory Consortium — CBER is the Center within FDA that regulates biological products for human use under applicable federal laws, including the Public Health Service Act and the Federal...

  20. Structural Biology and Molecular Applications Research

    Science.gov (United States)

    Part of NCI's Division of Cancer Biology's research portfolio, research and development in this area focuses on enabling technologies, models, and methodologies to support basic and applied cancer research.

  1. Optical Research and Field Services

    Science.gov (United States)

    2004-10-01

    Genetic approach, this proiect addresses Basic and Applied Research into the cell and molecular Physiology of actual and potential Biolo-gical Agents...able to renew our efforts on understanding the genetic makeup of the Alls-Gifford strain of Anthrax. 2.15. Associated Research Projects: PRK Support...the ACS included 12 patient visits for fitting Rigid Gas Permeable (RGP) contact lenses for keratoconus , Intra-ocular lens (IOL) follow-up care

  2. Statistics for Sleep and Biological Rhythms Research.

    Science.gov (United States)

    Klerman, Elizabeth B; Wang, Wei; Phillips, Andrew J K; Bianchi, Matt T

    2017-02-01

    This article is part of a Journal of Biological Rhythms series exploring analysis and statistical topics relevant to researchers in biological rhythms and sleep research. The goal is to provide an overview of the most common issues that arise in the analysis and interpretation of data in these fields. In this article, we address issues related to the collection of multiple data points from the same organism or system at different times, since such longitudinal data collection is fundamental to the assessment of biological rhythms. Rhythmic longitudinal data require additional specific statistical considerations, ranging from curve fitting to threshold definitions to accounting for correlation structure. We discuss statistical analyses of longitudinal data including issues of correlational structure and stationarity, markers of biological rhythms, demasking of biological rhythms, and determining phase, waveform, and amplitude of biological rhythms.

  3. Biological Dual-Use Research and Synthetic Biology of Yeast.

    Science.gov (United States)

    Cirigliano, Angela; Cenciarelli, Orlando; Malizia, Andrea; Bellecci, Carlo; Gaudio, Pasquale; Lioj, Michele; Rinaldi, Teresa

    2017-04-01

    In recent years, the publication of the studies on the transmissibility in mammals of the H5N1 influenza virus and synthetic genomes has triggered heated and concerned debate within the community of scientists on biological dual-use research; these papers have raised the awareness that, in some cases, fundamental research could be directed to harmful experiments, with the purpose of developing a weapon that could be used by a bioterrorist. Here is presented an overview regarding the dual-use concept and its related international agreements which underlines the work of the Australia Group (AG) Export Control Regime. It is hoped that the principles and activities of the AG, that focuses on export control of chemical and biological dual-use materials, will spread and become well known to academic researchers in different countries, as they exchange biological materials (i.e. plasmids, strains, antibodies, nucleic acids) and scientific papers. To this extent, and with the aim of drawing the attention of the scientific community that works with yeast to the so called Dual-Use Research of Concern, this article reports case studies on biological dual-use research and discusses a synthetic biology applied to the yeast Saccharomyces cerevisiae, namely the construction of the first eukaryotic synthetic chromosome of yeast and the use of yeast cells as a factory to produce opiates. Since this organism is considered harmless and is not included in any list of biological agents, yeast researchers should take simple actions in the future to avoid the sharing of strains and advanced technology with suspicious individuals.

  4. Manual on service business for policy research

    International Nuclear Information System (INIS)

    1999-01-01

    The contents of this book are summary of service business for policy research : conception classification and ways of service business for policy research, propel procedure of service business for policy research on system of committee, management, choice, contract, evaluation and post management, related regulation on service business for policy research : management regulation on service business for policy research, guide of evaluation for service business for policy research, estimation standard of policy research cost, law arrangement of national contract, required document on service business for policy research, and application manual for PRISM.

  5. Radioisotopes and ionizing radiations in biological research

    International Nuclear Information System (INIS)

    1984-01-01

    This book deals with the use of radioisotopes and ionizing radiations in the various aspects of biological research. The following topics were presented: labelled compounds; conformation-function relationships of hormonal polypeptides and their spectroscopic study; neutron scattering and neutron diffraction for biological studies; high resolution autoradiography; radioimmunoassay; nuclear medicine; transfer of excitation energy in photosynthesis; radioagronomy; radiation preservation of food [fr

  6. Petronas: research and scientific services

    International Nuclear Information System (INIS)

    1995-01-01

    Petroleum is one of Malaysia's major commodities. In 1993 alone, Malaysia exported about 21 million tonne crude petroleum and 3.4 million tonne of petroleum products with export value of about RM 9.2 billion. Despite the large local and export market of the fuel, our petroleum industry is facing several difficulties. The supply of petrol will inevitably deplete. The industry faces an increase in the exploration costs and decline in the discovery of large reserves. Petronas research and scientific services Sdn Bhd was established 3 years ago. The company which supports its holding company's needs in R and D started its history as an analytical laboratory in 1978. Today, it is one of the leading upstream and downstream petroleum research institute in this region

  7. Biology Education Research Trends in Turkey

    Science.gov (United States)

    Gul, Seyda; Sozbilir, Mustafa

    2015-01-01

    This paper reports on a content analysis of 633 biology education research [BER] papers published by Turkish science educators in national and international journals. The findings indicate that more research has been undertaken in environment and ecology, the cell and animal form and functions. In addition learning, teaching and attitudes were in…

  8. South African antarctic biological research programme

    CSIR Research Space (South Africa)

    SASCAR

    1981-07-01

    Full Text Available This document provides a description of the past, current and planned South African biological research activities in the sub-Antarctic and Antarctic regions. Future activities will fall under one of the five components of the research programme...

  9. Research data services in veterinary medicine libraries

    Directory of Open Access Journals (Sweden)

    Erin E. Kerby, MSI

    2017-01-01

    Conclusions: Lacking a standard definition of ‘‘research data’’ and a common understanding of precisely what research data services encompass, it is difficult for veterinary medicine librarians and libraries to define and understand their roles in research data services. Nonetheless, they appear to have an interest in learning more about and providing research data services.

  10. Should Soil Testing Services Measure Soil Biological Activity?

    Directory of Open Access Journals (Sweden)

    Alan J. Franzluebbers

    2016-02-01

    Full Text Available Health of agricultural soils depends largely on conservation management to promote soil organic matter accumulation. Total soil organic matter changes slowly, but active fractions are more dynamic. A key indicator of healthy soil is potential biological activity, which could be measured rapidly with soil testing services via the flush of CO during 1 to 3 d following rewetting of dried soil. The flush of CO is related to soil microbial biomass C and has repeatedly been shown strongly related to net N mineralization during standard aerobic incubations. New research is documenting the close association with plant N uptake in semicontrolled greenhouse conditions ( = 0.77, = 36. Field calibrations are underway to relate the flush of CO to the need for in-season N requirement in a variety of crops. An index of soil biological activity can and should be determined to help predict soil health and soil N availability.

  11. Research data services in veterinary medicine libraries.

    Science.gov (United States)

    Kerby, Erin E

    2016-10-01

    The study investigated veterinary medicine librarians' experience with and perceptions of research data services. Many academic libraries have begun to offer research data services in response to researchers' increased need for data management support. To date, such services have typically been generic, rather than discipline-specific, to appeal to a wide variety of researchers. An online survey was deployed to identify trends regarding research data services in veterinary medicine libraries. Participants were identified from a list of contacts from the MLA Veterinary Medical Libraries Section. Although many respondents indicated that they have a professional interest in research data services, the majority of veterinary medicine librarians only rarely or occasionally provide data management support as part of their regular job responsibilities. There was little consensus as to whether research data services should be core to a library's mission despite their perceived importance to the advancement of veterinary research. Furthermore, most respondents stated that research data services are just as or somewhat less important than the other services that they provide and feel only slightly or somewhat prepared to offer such services. Lacking a standard definition of "research data" and a common understanding of precisely what research data services encompass, it is difficult for veterinary medicine librarians and libraries to define and understand their roles in research data services. Nonetheless, they appear to have an interest in learning more about and providing research data services.

  12. CSBB: synthetic biology research at Newcastle University

    Science.gov (United States)

    Wipat, Anil; Krasnogor, Natalio

    2017-01-01

    The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties — Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts and Social Sciences. The CSBB focuses on many different areas of Synthetic Biology, including bioprocessing, computational design and in vivo computation, as well as improving understanding of basic molecular machinery. Such breadth is supported by major national and international research funding, a range of industrial partners in the North East of England and beyond, as well as a large number of doctoral and post-doctoral researchers. The CSBB trains the next generation of scientists through a 1-year MSc in Synthetic Biology. PMID:28620039

  13. CSBB: synthetic biology research at Newcastle University.

    Science.gov (United States)

    Goñi-Moreno, Angel; Wipat, Anil; Krasnogor, Natalio

    2017-06-15

    The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties - Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts and Social Sciences. The CSBB focuses on many different areas of Synthetic Biology, including bioprocessing, computational design and in vivo computation, as well as improving understanding of basic molecular machinery. Such breadth is supported by major national and international research funding, a range of industrial partners in the North East of England and beyond, as well as a large number of doctoral and post-doctoral researchers. The CSBB trains the next generation of scientists through a 1-year MSc in Synthetic Biology. © 2017 The Author(s).

  14. Advances in nicotine research in Addiction Biology.

    Science.gov (United States)

    Bernardi, Rick E

    2015-09-01

    The aim of Addiction Biology is to advance our understanding of the action of drugs of abuse and addictive processes via the publication of high-impact clinical and pre-clinical findings resulting from behavioral, molecular, genetic, biochemical, neurobiological and pharmacological research. As of 2013, Addiction Biology is ranked number 1 in the category of Substance Abuse journals (SCI). Occasionally, Addiction Biology likes to highlight via review important findings focused on a particular topic and recently published in the journal. The current review summarizes a number of key publications from Addiction Biology that have contributed to the current knowledge of nicotine research, comprising a wide spectrum of approaches, both clinical and pre-clinical, at the cellular, molecular, systems and behavioral levels. A number of findings from human studies have identified, using imaging techniques, alterations in common brain circuits, as well as morphological and network activity changes, associated with tobacco use. Furthermore, both clinical and pre-clinical studies have characterized a number of mechanistic targets critical to understanding the effects of nicotine and tobacco addiction. Together, these findings will undoubtedly drive future studies examining the dramatic impact of tobacco use and the development of treatments to counter nicotine dependence. © 2015 Society for the Study of Addiction.

  15. Research evaluation support services in biomedical libraries.

    Science.gov (United States)

    Gutzman, Karen Elizabeth; Bales, Michael E; Belter, Christopher W; Chambers, Thane; Chan, Liza; Holmes, Kristi L; Lu, Ya-Ling; Palmer, Lisa A; Reznik-Zellen, Rebecca C; Sarli, Cathy C; Suiter, Amy M; Wheeler, Terrie R

    2018-01-01

    The paper provides a review of current practices related to evaluation support services reported by seven biomedical and research libraries. A group of seven libraries from the United States and Canada described their experiences with establishing evaluation support services at their libraries. A questionnaire was distributed among the libraries to elicit information as to program development, service and staffing models, campus partnerships, training, products such as tools and reports, and resources used for evaluation support services. The libraries also reported interesting projects, lessons learned, and future plans. The seven libraries profiled in this paper report a variety of service models in providing evaluation support services to meet the needs of campus stakeholders. The service models range from research center cores, partnerships with research groups, and library programs with staff dedicated to evaluation support services. A variety of products and services were described such as an automated tool to develop rank-based metrics, consultation on appropriate metrics to use for evaluation, customized publication and citation reports, resource guides, classes and training, and others. Implementing these services has allowed the libraries to expand their roles on campus and to contribute more directly to the research missions of their institutions. Libraries can leverage a variety of evaluation support services as an opportunity to successfully meet an array of challenges confronting the biomedical research community, including robust efforts to report and demonstrate tangible and meaningful outcomes of biomedical research and clinical care. These services represent a transformative direction that can be emulated by other biomedical and research libraries.

  16. Pre-Service Science Teachers' Pedagogical Content Knowledge in the Physics, Chemistry, and Biology Topics

    Science.gov (United States)

    Bektas, Oktay

    2015-01-01

    This study investigated pre-service science teachers' pedagogical content knowledge in the physics, chemistry, and biology topics. These topics were the light and sound, the physical and chemical changes, and reproduction, growth, and evolution. Qualitative research design was utilized. Data were collected from 33 pre-service science teachers…

  17. Onchocerciasis control: biological research is still needed

    Directory of Open Access Journals (Sweden)

    Boussinesq M.

    2008-09-01

    Full Text Available Achievements obtained by the onchocerciasis control programmes should not lead to a relaxation in the biological research on Onchocerca volvulus. Issues such as the Loa loa-related postivermectin serious adverse events, the uncertainties as to whether onchocerciasis can be eliminated by ivermectin treatments, and the possible emergence of ivermectin-resistant O. volvulus populations should be addressed proactively. Doxycycline, moxidectin and emodepside appear to be promising as alternative drugs against onchocerciasis but support to researches in immunology and genomics should also be increased to develop new control tools, including both vaccines and macrofilaricidal drugs.

  18. Biological effectiveness of neutrons: Research needs

    Energy Technology Data Exchange (ETDEWEB)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy.

  19. Biological effectiveness of neutrons: Research needs

    International Nuclear Information System (INIS)

    Casarett, G.W.; Braby, L.A.; Broerse, J.J.; Elkind, M.M.; Goodhead, D.T.; Oleinick, N.L.

    1994-02-01

    The goal of this report was to provide a conceptual plan for a research program that would provide a basis for determining more precisely the biological effectiveness of neutron radiation with emphasis on endpoints relevant to the protection of human health. This report presents the findings of the experts for seven particular categories of scientific information on neutron biological effectiveness. Chapter 2 examines the radiobiological mechanisms underlying the assumptions used to estimate human risk from neutrons and other radiations. Chapter 3 discusses the qualitative and quantitative models used to organize and evaluate experimental observations and to provide extrapolations where direct observations cannot be made. Chapter 4 discusses the physical principles governing the interaction of radiation with biological systems and the importance of accurate dosimetry in evaluating radiation risk and reducing the uncertainty in the biological data. Chapter 5 deals with the chemical and molecular changes underlying cellular responses and the LET dependence of these changes. Chapter 6, in turn, discusses those cellular and genetic changes which lead to mutation or neoplastic transformation. Chapters 7 and 8 examine deterministic and stochastic effects, respectively, and the data required for the prediction of such effects at different organizational levels and for the extrapolation from experimental results in animals to risks for man. Gaps and uncertainties in this data are examined relative to data required for establishing radiation protection standards for neutrons and procedures for the effective and safe use of neutron and other high-LET radiation therapy

  20. Linking ecosystem services with cultural landscape research

    DEFF Research Database (Denmark)

    Schaich, Harald; Biding, Claudia; Plieninger, Tobias

    2010-01-01

    The concept of ecosystem services facilitates the valuation of the multiple services from ecosystems and landscapes, the identification of trade-offs between different land use scenarios, and also informs decision making in land use planning. Unfortunately, cultural services have been mostly...... neglected within the ecosystem services framework. This could result in trade-off assessments which are biased and mislead ecosystem management and landscape planning. However, cultural landscape research approaches have proven valuable in the assessment of different nonmaterial landscape values...... and cultural services. In this paper, we compare the objectives, approaches, and methodologies adopted by ecosystem services research and cultural landscape research through a bibliographic research. Both research communities investigate the human dimension of ecosystems and landscapes and, hence, study...

  1. Gordon Research Conference on Mammary Gland Biology

    International Nuclear Information System (INIS)

    1989-01-01

    The 1989 conference was the tenth in the series of biennial Gordon Research Conferences on Mammary Gland Biology. Traditionally this conference brings together scientists from diverse backgrounds and experience but with a common interest in the biology of the mammary gland. Investigators from agricultural and medical schools, biochemists, cell and molecular biologists, endocrinologists, immunologists, and representatives from the emerging biotechnology industries met to discuss current concepts and results on the function and regulation of the normal and neoplastic mammary gland in a variety of species. Of the participants, approximately three-fourths were engaged in studying the normal mammary gland function, whereas the other quarter were engaged in studying the neoplastic gland. The interactions between scientists, clinicians, veterinarians examining both normal and neoplastic cell function serves to foster the multi-disciplinary goals of the conference and has stimulated many cooperative projects among participants in previous years

  2. Research in Library Reference/Information Service.

    Science.gov (United States)

    Lynch, Mary Jo

    1983-01-01

    This review of library reference service research, which focuses on the provision of information in response to questions, covers measurement of reference service, evaluation using unobtrusive techniques, online search services, information needs and uses, the process of asking and answering questions, and artificial intelligence. Eighty-four…

  3. Applications of NMR in biological metabolic research

    International Nuclear Information System (INIS)

    Nie Jiarui; Li Xiuqin; He Chunjian

    1989-01-01

    The nuclear magnetic resonance has become a powerful means of studying biological metabolism in non-invasive and non-destructive way. Being used to study the metabolic processes of living system in normal physiological conditions as well as in molecular level, the method is better than other conventional approaches. Using important parameters such as NMR-chemical shifts, longitudinal relaxation time and transverse relaxation time, it is possible to probe the metabolic processes as well as conformation, concentration, transportation and distribution of reacting and resulting substances. The NMR spectroscopy of 1 H, 31 P and 13 C nuclei has already been widely used in metabolic researches

  4. 75 FR 6401 - Medical Devices Regulated by the Center for Biologics Evaluation and Research; Availability of...

    Science.gov (United States)

    2010-02-09

    ... Biologics Evaluation and Research (HFM-17), Food and Drug Administration, suite 200N, 1401 Rockville Pike... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2009-M-0513] Medical Devices Regulated by the Center for Biologics Evaluation and Research; Availability of Summaries...

  5. [Marketing research in health service].

    Science.gov (United States)

    Ameri, Cinzia; Fiorini, Fulvio

    2015-01-01

    Marketing research is the systematic and objective search for, and analysis of, information relevant to the identification and solution of any problem in the field of marketing. The key words in this definition are: systematic, objective and analysis. Marketing research seeks to set about its task in a systematic and objective fashion. This means that a detailed and carefully designed research plan is developed in which each stage of the research is specified. Such a research plan is only considered adequate if it specifies: the research problem in concise and precise terms, the information necessary to address the problem, the methods to be employed in gathering the information and the analytical techniques to be used to interpret it. Maintaining objectivity in marketing research is essential if marketing management is to have sufficient confidence in its results to be prepared to take risky decisions based upon those results. To this end, as far as possible, marketing researchers employ the scientific method. The characteristics of the scientific method are that it translates personal prejudices, notions and opinions into explicit propositions (or hypotheses). These are tested empirically. At the same time alternative explanations of the event or phenomena of interest are given equal consideration.

  6. Biological and Environmental Research Network Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Balaji, V. [Princeton Univ., NJ (United States). Earth Science Grid Federation (ESGF); Boden, Tom [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Cowley, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dart, Eli [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Dattoria, Vince [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Desai, Narayan [Argonne National Lab. (ANL), Argonne, IL (United States); Egan, Rob [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Foster, Ian [Argonne National Lab. (ANL), Argonne, IL (United States); Goldstone, Robin [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gregurick, Susan [U.S. Dept. of Energy, Washington, DC (United States). Biological Systems Science Division; Houghton, John [U.S. Dept. of Energy, Washington, DC (United States). Biological and Environmental Research (BER) Program; Izaurralde, Cesar [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Johnston, Bill [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Joseph, Renu [U.S. Dept. of Energy, Washington, DC (United States). Climate and Environmental Sciences Division; Kleese-van Dam, Kerstin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lipton, Mary [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Monga, Inder [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Pritchard, Matt [British Atmospheric Data Centre (BADC), Oxon (United Kingdom); Rotman, Lauren [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Strand, Gary [National Center for Atmospheric Research (NCAR), Boulder, CO (United States); Stuart, Cory [Argonne National Lab. (ANL), Argonne, IL (United States); Tatusova, Tatiana [National Inst. of Health (NIH), Bethesda, MD (United States); Tierney, Brian [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). ESNet; Thomas, Brian [Univ. of California, Berkeley, CA (United States); Williams, Dean N. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Zurawski, Jason [Internet2, Washington, DC (United States)

    2013-09-01

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the U.S. Department of Energy (DOE) Office of Science (SC), the single largest supporter of basic research in the physical sciences in the United States. In support of SC programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet be a highly successful enabler of scientific discovery for over 25 years. In November 2012, ESnet and the Office of Biological and Environmental Research (BER) of the DOE SC organized a review to characterize the networking requirements of the programs funded by the BER program office. Several key findings resulted from the review. Among them: 1) The scale of data sets available to science collaborations continues to increase exponentially. This has broad impact, both on the network and on the computational and storage systems connected to the network. 2) Many science collaborations require assistance to cope with the systems and network engineering challenges inherent in managing the rapid growth in data scale. 3) Several science domains operate distributed facilities that rely on high-performance networking for success. Key examples illustrated in this report include the Earth System Grid Federation (ESGF) and the Systems Biology Knowledgebase (KBase). This report expands on these points, and addresses others as well. The report contains a findings section as well as the text of the case studies discussed at the review.

  7. 2010 Plant Molecular Biology Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Michael Sussman

    2010-07-23

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.

  8. Division of Biological and Medical Research annual research summary, 1983

    International Nuclear Information System (INIS)

    Barr, S.H.

    1984-08-01

    This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology

  9. Division of Biological and Medical Research annual research summary, 1983

    Energy Technology Data Exchange (ETDEWEB)

    Barr, S.H. (ed.)

    1984-08-01

    This research summary contains brief descriptions of research in the following areas: (1) mechanisms of hepatocarcinogenesis; (2) role of metals in cocarcinogenesis and the use of liposomes for metal mobilization; (3) control of mutagenesis and cell differentiation in cultured cells by tumor promoters; (4) radiation effects in mammalian cells; (5) radiation carcinogenesis and radioprotectors; (6) life shortening, tumor induction, and tissue dose for fission-neutron and gamma-ray irradiations; (7) mammalian genetics and biostatistics; (8) radiation toxicity studies; (9) hematopoiesis in chronic toxicity; (10) molecular biology studies; (11) chemical toxicology; (12) carcinogen identification and metabolism; (13) metal metabolism and toxicity; and (14) neurobehavioral chronobiology. (ACR)

  10. Future Direction of USDA Forest Service Research

    Science.gov (United States)

    A. Dan Wilson

    1995-01-01

    The USDA Forest Service has been involved in Texas oak wilt research since 1976. Despite research successes, there are still many important research areas that have not been addressed or sufficiently investigated to answer the key questions required for making sound disease management decisions. Some of the priority areas planned for future research by the Southern...

  11. THE ABILITY OF QUANTITATIVE LITERACY OF PRE-SERVICE BIOLOGY STUDENTS

    OpenAIRE

    Ryan Ardiansyah; Dea Diella

    2017-01-01

    This research have purpose to know and describe quantitative literacy of pre-service biology students based on six indicators of quantitative literacy. Methods used is descriptive with study survey. This research carried out at Siliwangi University with the subject as many as 30 pre-service biology students who take plant anatomy course. Based on the analysis of test and interview obtained that of 30 students, 4 students (13.3%) in high category, 10 students (33.3%) in medium category, and 16...

  12. Molecular biology approaches in bioadhesion research

    Directory of Open Access Journals (Sweden)

    Marcelo Rodrigues

    2014-07-01

    Full Text Available The use of molecular biology tools in the field of bioadhesion is still in its infancy. For new research groups who are considering taking a molecular approach, the techniques presented here are essential to unravelling the sequence of a gene, its expression and its biological function. Here we provide an outline for addressing adhesion-related genes in diverse organisms. We show how to gradually narrow down the number of candidate transcripts that are involved in adhesion by (1 generating a transcriptome and a differentially expressed cDNA list enriched for adhesion-related transcripts, (2 setting up a BLAST search facility, (3 perform an in situ hybridization screen, and (4 functional analyses of selected genes by using RNA interference knock-down. Furthermore, latest developments in genome-editing are presented as new tools to study gene function. By using this iterative multi-technologies approach, the identification, isolation, expression and function of adhesion-related genes can be studied in most organisms. These tools will improve our understanding of the diversity of molecules used for adhesion in different organisms and these findings will help to develop innovative bio-inspired adhesives.

  13. The Learning of Biology: A Structural Basis for Future Research

    Science.gov (United States)

    Murray, Darrel L.

    1977-01-01

    This article reviews recent research studies and experiences relating the learning theories of Ausubel to biology instruction. Also some suggestions are made for future research on the learning of biology. (MR)

  14. Persistence and Availability of Web Services in Computational Biology

    Science.gov (United States)

    Schultheiss, Sebastian J.; Münch, Marc-Christian; Andreeva, Gergana D.; Rätsch, Gunnar

    2011-01-01

    We have conducted a study on the long-term availability of bioinformatics Web services: an observation of 927 Web services published in the annual Nucleic Acids Research Web Server Issues between 2003 and 2009. We found that 72% of Web sites are still available at the published addresses, only 9% of services are completely unavailable. Older addresses often redirect to new pages. We checked the functionality of all available services: for 33%, we could not test functionality because there was no example data or a related problem; 13% were truly no longer working as expected; we could positively confirm functionality only for 45% of all services. Additionally, we conducted a survey among 872 Web Server Issue corresponding authors; 274 replied. 78% of all respondents indicate their services have been developed solely by students and researchers without a permanent position. Consequently, these services are in danger of falling into disrepair after the original developers move to another institution, and indeed, for 24% of services, there is no plan for maintenance, according to the respondents. We introduce a Web service quality scoring system that correlates with the number of citations: services with a high score are cited 1.8 times more often than low-scoring services. We have identified key characteristics that are predictive of a service's survival, providing reviewers, editors, and Web service developers with the means to assess or improve Web services. A Web service conforming to these criteria receives more citations and provides more reliable service for its users. The most effective way of ensuring continued access to a service is a persistent Web address, offered either by the publishing journal, or created on the authors' own initiative, for example at http://bioweb.me. The community would benefit the most from a policy requiring any source code needed to reproduce results to be deposited in a public repository. PMID:21966383

  15. Mining biological pathways using WikiPathways web services.

    Science.gov (United States)

    Kelder, Thomas; Pico, Alexander R; Hanspers, Kristina; van Iersel, Martijn P; Evelo, Chris; Conklin, Bruce R

    2009-07-30

    WikiPathways is a platform for creating, updating, and sharing biological pathways [1]. Pathways can be edited and downloaded using the wiki-style website. Here we present a SOAP web service that provides programmatic access to WikiPathways that is complementary to the website. We describe the functionality that this web service offers and discuss several use cases in detail. Exposing WikiPathways through a web service opens up new ways of utilizing pathway information and assisting the community curation process.

  16. Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements.

    Science.gov (United States)

    Kohl, Alain; Pondeville, Emilie; Schnettler, Esther; Crisanti, Andrea; Supparo, Clelia; Christophides, George K; Kersey, Paul J; Maslen, Gareth L; Takken, Willem; Koenraadt, Constantianus J M; Oliva, Clelia F; Busquets, Núria; Abad, F Xavier; Failloux, Anna-Bella; Levashina, Elena A; Wilson, Anthony J; Veronesi, Eva; Pichard, Maëlle; Arnaud Marsh, Sarah; Simard, Frédéric; Vernick, Kenneth D

    2016-01-01

    Vector-borne pathogens impact public health, animal production, and animal welfare. Research on arthropod vectors such as mosquitoes, ticks, sandflies, and midges which transmit pathogens to humans and economically important animals is crucial for development of new control measures that target transmission by the vector. While insecticides are an important part of this arsenal, appearance of resistance mechanisms is increasingly common. Novel tools for genetic manipulation of vectors, use of Wolbachia endosymbiotic bacteria, and other biological control mechanisms to prevent pathogen transmission have led to promising new intervention strategies, adding to strong interest in vector biology and genetics as well as vector-pathogen interactions. Vector research is therefore at a crucial juncture, and strategic decisions on future research directions and research infrastructure investment should be informed by the research community. A survey initiated by the European Horizon 2020 INFRAVEC-2 consortium set out to canvass priorities in the vector biology research community and to determine key activities that are needed for researchers to efficiently study vectors, vector-pathogen interactions, as well as access the structures and services that allow such activities to be carried out. We summarize the most important findings of the survey which in particular reflect the priorities of researchers in European countries, and which will be of use to stakeholders that include researchers, government, and research organizations.

  17. Research protocols in National Park Service wilderness

    Science.gov (United States)

    Jim Walters

    2000-01-01

    While the National Park Service encourages the use of its wilderness resource for research, management policies require that all research apply “minimum requirement” protocols to determine: 1) if the research is needed to support the purposes of wilderness and, 2) if it is appropriate, determine the minimum tool needed to accomplish the work.

  18. E-Services in Danish Research Libraries

    DEFF Research Database (Denmark)

    Scupola, Ada

    2008-01-01

    This chapter reports the findings of a case study of e-services adoption at research libraries. The case under consideration is Roskilde University Library (RUB), a research library supporting learning activities at Roskilde University. The research focuses on the main issues that RUB had to deal...

  19. Service Learning: Applications and Research in Business

    Science.gov (United States)

    Andrews, Christine P.

    2007-01-01

    Researchers have described "service learning" as an ideal way to integrate experiential education into coursework while meeting community needs and imbuing students with civic responsibility. They have advocated service learning in business as a method to implement course concepts and increase student understanding of the external environment. In…

  20. Biological research for the radiation protection

    International Nuclear Information System (INIS)

    Kim, In Gyu; Kim, Chan Kug; Shim, Hae Won; Jung, Il Lae; Byun, Hee Sun; Moon, Myung Sook; Cho, Hye Jeong; Kim, Jin Sik

    2003-04-01

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about polyamine effect on cell death triggered ionizing radiation, H 2 O 2 and toxic agents. In this paper, to elucidate the role of polyamines as mediator in lysosomal damage and stress(H 2 O 2 )- induced apoptosis, we utilized α-DiFluoroMethylOrnithine (DFMO), which inhibited ornithine decarboxylase and depleted intracellular putrescine, and investigated the effects of polyamine on the apoptosis caused by H 2 O 2 , ionizing radiation and paraquat. We also showed that MGBG, inhibitor of polyamine biosynthesis, treatment affected intracellular redox steady states, intracellular ROS levels and protein oxidation. Thereafter we also investigated whether MGBG may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation or H 2 O 2 because such compounds are able to potentiate the cell-killing effects. In addition, ceruloplasmin and thioredoxin, possible antioxidant proteins, were shown to have protective effect on radiation- or H 2 O 2 (or chemicals)-induced macromolecular damage or cell death

  1. Biological research for the radiation protection

    Energy Technology Data Exchange (ETDEWEB)

    Kim, In Gyu; Kim, Chan Kug; Shim, Hae Won; Jung, Il Lae; Byun, Hee Sun; Moon, Myung Sook; Cho, Hye Jeong; Kim, Jin Sik

    2003-04-01

    The work scope of 'Biological Research for the Radiation Protection' had contained the research about polyamine effect on cell death triggered ionizing radiation, H{sub 2}O{sub 2} and toxic agents. In this paper, to elucidate the role of polyamines as mediator in lysosomal damage and stress(H{sub 2}O{sub 2})- induced apoptosis, we utilized {alpha}-DiFluoroMethylOrnithine (DFMO), which inhibited ornithine decarboxylase and depleted intracellular putrescine, and investigated the effects of polyamine on the apoptosis caused by H{sub 2}O{sub 2}, ionizing radiation and paraquat. We also showed that MGBG, inhibitor of polyamine biosynthesis, treatment affected intracellular redox steady states, intracellular ROS levels and protein oxidation. Thereafter we also investigated whether MGBG may enhance the cytotoxic efficacy of tumor cells caused by ionizing radiation or H{sub 2}O{sub 2} because such compounds are able to potentiate the cell-killing effects. In addition, ceruloplasmin and thioredoxin, possible antioxidant proteins, were shown to have protective effect on radiation- or H{sub 2}O{sub 2}(or chemicals)-induced macromolecular damage or cell death.

  2. [Qualitative research in health services research - discussion paper, Part 2: Qualitative research in health services research in Germany - an overview].

    Science.gov (United States)

    Karbach, U; Stamer, M; Holmberg, C; Güthlin, C; Patzelt, C; Meyer, T

    2012-08-01

    This is the second part of a 3-part discussion paper by the working group on "Qualitative Methods" in the German network of health services research (DNVF) that shall contribute to the development of a memorandum concerning qualitative health services research. It aims to depict the different types of qualitative research that are conducted in health services research in Germany. In addition, the authors present a specific set of qualitative data collection and analysis tools to demonstrate the potential of qualitative research for health services research. QUALITATIVE RESEARCH IN HEALTH SERVICES RESEARCH - AN OVERVIEW: To give an overview of the types of qualitative research conducted in German health services research, the abstracts of the 8th German Conference on Health Services Research were filtered to identify qualitative or mixed-methods studies. These were then analysed by looking at the context which was studied, who was studied, the aims of the studies, and what type of methods were used. Those methods that were mentioned most often for data collection and analysis are described in detail. QUALITATIVE RESEARCH AT THE CONFERENCE FOR HEALTH SERVICES RESEARCH 2009: Approximately a fifth of all abstracts (n=74) had a qualitative (n=47) or a mixed-methods approach combining quantitative and qualitative methods (n=27). Research aims included needs assessment (41%), survey development (36%), evaluation (22%), and theorizing (1%). Data collection mostly consisted of one-on-one interviews (n=45) and group discussions (n=29). Qualitative content analysis was named in 35 abstracts, 30 abstracts did not reference their method of analysis. In addition to a quantitative summary of the abstract findings, the diversity of fields addressed by qualitative methods is highlighted. Although drawing conclusions on the use of qualitative methods in German health services research from the analysis of conference abstracts is not possible, the overview we present demonstrates the

  3. Radiation chemistry in development and research of radiation biology

    International Nuclear Information System (INIS)

    Min Rui

    2010-01-01

    During the establishment and development of radiation biology, radiation chemistry acts like bridge which units the spatial and temporal insight coming from radiation physics with radiation biology. The theory, model, and methodology of radiation chemistry play an important role in promoting research and development of radiation biology. Following research development of radiation biology effects towards systems radiation biology the illustration and exploration both diversity of biological responses and complex process of biological effect occurring remain to need the theory, model, and methodology come from radiation chemistry. (authors)

  4. Pre-Service Science Teachers’ Pedagogical Content Knowledge in The Physics, Chemistry, and Biology Topics

    OpenAIRE

    Bektas, Oktay

    2015-01-01

    This study investigated pre-service science teachers’ pedagogical content knowledge in the physics, chemistry, and biology topics. These topics were the light and sound, the physical and chemical changes, and reproduction, growth, and evolution. Qualitative research design was utilized. Data were collected from 33 pre-service science teachers (PSTs) by using open-ended questions. Data analysis was performed using descriptive analysis. The results indicated that some PCTs have sufficient infor...

  5. 78 FR 6087 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2013-01-29

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and.... Department of Energy, Office of Science, Office of Biological and Environmental Research, SC-23/Germantown...

  6. 77 FR 4028 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2012-01-26

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy; Office of Science. ACTION: Notice of Open Meeting. SUMMARY: This notice announces a meeting of the Biological and... of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence Avenue SW...

  7. White Paper on Research Data Service Discoverability

    Directory of Open Access Journals (Sweden)

    Costantino Thanos

    2016-12-01

    Full Text Available This White Paper reports the outcome of a Workshop on “Research Data Service Discoverability” held in the island of Santorini (GR on 21–22 April 2016 and organized in the context of the EU funded Project “RDA-E3”. The Workshop addressed the main technical problems that hamper an efficient and effective discovery of Research Data Services (RDSs based on appropriate semantic descriptions of their functional and non-functional aspects. In the context of this White Paper, by RDSs are meant those data services that manipulate/transform research datasets for the purpose of gaining insight into complicated issues. In this White Paper, the main concepts involved in the discovery process of RDSs are defined; the RDS discovery process is illustrated; the main technologies that enable the discovery of RDSs are described; and a number of recommendations are formulated for indicating future research directions and making an automatic RDS discovery feasible.

  8. pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students

    Science.gov (United States)

    Campbell, A. Malcolm; Eckdahl, Todd; Cronk, Brian; Andresen, Corinne; Frederick, Paul; Huckuntod, Samantha; Shinneman, Claire; Wacker, Annie; Yuan, Jason

    2014-01-01

    The "Vision and Change" report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area…

  9. Dairy and functional foods research in the Agricultural Research Service

    Science.gov (United States)

    The Dairy and Functional Foods Research Unit is the only group in the Agricultural Research Service that is dedicated to solving critical problems in milk utilization and fruit and vegetable byproducts from specialty crops. The many areas of investigation include development of specialty cheese, c...

  10. Plant biology research and training for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, K. (ed.)

    1992-01-01

    The committee was assembled in response to a request from the National Science Foundation (NSF), the US Department of Agriculture (USDA), and the US Department of Energy (DoE). The leadership of these agencies asked the National Academy of Sciences through the National Research Council (NRC) to assess the status of plant-science research in the United States in light of the opportunities arising from advances inother areas of biology. NRC was asked to suggest ways of accelerating the application of these new biologic concepts and tools to research in plant science with the aim of enhancing the acquisition of new knowledge about plants. The charge to the committee was to examine the following: Organizations, departments, and institutions conducting plant biology research; human resources involved in plant biology research; graduate training programs in plant biology; federal, state, and private sources of support for plant-biology research; the role of industry in conducting and supporting plant-biology research; the international status of US plant-biology research; and the relationship of plant biology to leading-edge research in biology.

  11. Plant biology research and training for the 21st century

    Energy Technology Data Exchange (ETDEWEB)

    Kelly, K. [ed.

    1992-12-31

    The committee was assembled in response to a request from the National Science Foundation (NSF), the US Department of Agriculture (USDA), and the US Department of Energy (DoE). The leadership of these agencies asked the National Academy of Sciences through the National Research Council (NRC) to assess the status of plant-science research in the United States in light of the opportunities arising from advances inother areas of biology. NRC was asked to suggest ways of accelerating the application of these new biologic concepts and tools to research in plant science with the aim of enhancing the acquisition of new knowledge about plants. The charge to the committee was to examine the following: Organizations, departments, and institutions conducting plant biology research; human resources involved in plant biology research; graduate training programs in plant biology; federal, state, and private sources of support for plant-biology research; the role of industry in conducting and supporting plant-biology research; the international status of US plant-biology research; and the relationship of plant biology to leading-edge research in biology.

  12. Towards a lightweight generic computational grid framework for biological research

    Directory of Open Access Journals (Sweden)

    Shepherd Adrian J

    2008-10-01

    Full Text Available Abstract Background An increasing number of scientific research projects require access to large-scale computational resources. This is particularly true in the biological field, whether to facilitate the analysis of large high-throughput data sets, or to perform large numbers of complex simulations – a characteristic of the emerging field of systems biology. Results In this paper we present a lightweight generic framework for combining disparate computational resources at multiple sites (ranging from local computers and clusters to established national Grid services. A detailed guide describing how to set up the framework is available from the following URL: http://igrid-ext.cryst.bbk.ac.uk/portal_guide/. Conclusion This approach is particularly (but not exclusively appropriate for large-scale biology projects with multiple collaborators working at different national or international sites. The framework is relatively easy to set up, hides the complexity of Grid middleware from the user, and provides access to resources through a single, uniform interface. It has been developed as part of the European ImmunoGrid project.

  13. Social justice and research using human biological material: A ...

    African Journals Online (AJOL)

    Social justice in the context of research using human biological material is an important contemporary legal-ethical issue. A question at the heart of this issue is the following: Is it fair to expect a research participant (a person who participates in such research by, among others, making available biological material from his or ...

  14. Structural biology computing: Lessons for the biomedical research sciences.

    Science.gov (United States)

    Morin, Andrew; Sliz, Piotr

    2013-11-01

    The field of structural biology, whose aim is to elucidate the molecular and atomic structures of biological macromolecules, has long been at the forefront of biomedical sciences in adopting and developing computational research methods. Operating at the intersection between biophysics, biochemistry, and molecular biology, structural biology's growth into a foundational framework on which many concepts and findings of molecular biology are interpreted1 has depended largely on parallel advancements in computational tools and techniques. Without these computing advances, modern structural biology would likely have remained an exclusive pursuit practiced by few, and not become the widely practiced, foundational field it is today. As other areas of biomedical research increasingly embrace research computing techniques, the successes, failures and lessons of structural biology computing can serve as a useful guide to progress in other biomedically related research fields. Copyright © 2013 Wiley Periodicals, Inc.

  15. BioServices: a common Python package to access biological Web Services programmatically.

    Science.gov (United States)

    Cokelaer, Thomas; Pultz, Dennis; Harder, Lea M; Serra-Musach, Jordi; Saez-Rodriguez, Julio

    2013-12-15

    Web interfaces provide access to numerous biological databases. Many can be accessed to in a programmatic way thanks to Web Services. Building applications that combine several of them would benefit from a single framework. BioServices is a comprehensive Python framework that provides programmatic access to major bioinformatics Web Services (e.g. KEGG, UniProt, BioModels, ChEMBLdb). Wrapping additional Web Services based either on Representational State Transfer or Simple Object Access Protocol/Web Services Description Language technologies is eased by the usage of object-oriented programming. BioServices releases and documentation are available at http://pypi.python.org/pypi/bioservices under a GPL-v3 license.

  16. Counseling Services and Student Success. Research Brief

    Science.gov (United States)

    Francis, Perry C.; Horn, Aaron S.

    2016-01-01

    The purpose of this research brief is to provide an overview of mental health issues and counseling services on college campuses. The findings from several national surveys are reviewed to estimate the prevalence of anxiety and depression, suicide and suicidal ideation, and violence among college students. Common prevention and treatment programs…

  17. Forest Service research natural areas in California

    Science.gov (United States)

    Sheauchi Cheng

    2004-01-01

    Ecological descriptions of 98 research natural areas (of various statuses) in the Pacific Southwest Region of the USDA Forest Service are summarized in this report. These descriptions, basically based on ecological surveys conducted from 1975 through 2000, provide important but largely unknown information on the ecology of California. For each area, descriptions of...

  18. Research and services provision on the world research market

    Directory of Open Access Journals (Sweden)

    Witold Wiśniowski

    2013-03-01

    Full Text Available It is necessary to create new knowledge for the development of the economy. The source of new knowledge are research: basic, applied and industrial, which complement each other to form one whole. Each of these research has other sources of financing and other purposes. Due to the large influx of foreign technology to Poland industrial research is not growing as we would expect. To balance this deficiency the Research Institutes may provide services on the world market. It would be advisable to seek the provision of services on the global research market so that it could became a Polish smart specialization. This specialization would include the sale of intellect, which should never run out of customers.

  19. Postharvest biology and technology research and development ...

    African Journals Online (AJOL)

    The applications of biological control agents in pre- and post-harvest operations and modified atmosphere packaging and related technology in post harvest handling of fresh fruits and vegetables, in addition to the use of hot water treatment as a non-chemical alternative in keeping quality during post harvest handling of ...

  20. Haldane's Contributions to Biological Research in India

    Indian Academy of Sciences (India)

    evolutionary biology. Haldane advised that "if you want to excel in science, try to develop the habit of quantitative thinking". Partha P Majumder. After a few brief visits to India in quick succession, J B S. Haldane accepted P C Mahalanobis's invitation and moved to. India to join the Indian Statistical Institute, Calcutta, as a.

  1. The Health Services Research Workforce: Current Stock

    Science.gov (United States)

    McGinnis, Sandra; Moore, Jean

    2009-01-01

    Objective To examine the size and characteristics of the health services research (HSR) workforce; the job satisfaction, job security, and future plans reported by the workforce; and the future of the HSR workforce supply. Data Sources (1) AcademyHealth active and lapsed members since 2000 and annual research meeting presenters and interest group participants; (2) principal investigators of research projects listed in the HSRProj database; and (3) authors of articles published in two HSR journals. Study Design Data on investigators conducting HSR in selected venues were collected and compared in order to identify the percentage of the HSR workforce represented in the “core” versus related disciplines and to investigate the extent to which the “core” researchers publish, present, or participate in disciplinary venues. Principal Findings The field appears to have grown dramatically since 1995, from an estimated 5,000 health services researchers to an estimated 11,596 in 2007. This is a broad workforce characterized by various levels of involvement in the field. Some researchers self-identify with the field of HSR, while others are associated primarily with venues related to specific disciplines. Many researchers who identify with HSR also publish in venues related to multiple other disciplines. Conclusions The field may face future challenges related to demographic change, such as an aging workforce and an increased need for diversity. International collaboration appears common, and in the future the field may need to be defined internationally rather than nationally. At the same time, there are also many indications that HSR is a good field to work in. Health services researchers reported high levels of satisfaction with their profession and current employer, as well as little desire to change jobs and little concern about job security. PMID:20459584

  2. The health services research workforce: current stock.

    Science.gov (United States)

    McGinnis, Sandra; Moore, Jean

    2009-12-01

    To examine the size and characteristics of the health services research (HSR) workforce; the job satisfaction, job security, and future plans reported by the workforce; and the future of the HSR workforce supply. (1) AcademyHealth active and lapsed members since 2000 and annual research meeting presenters and interest group participants; (2) principal investigators of research projects listed in the HSRProj database; and (3) authors of articles published in two HSR journals. Data on investigators conducting HSR in selected venues were collected and compared in order to identify the percentage of the HSR workforce represented in the "core" versus related disciplines and to investigate the extent to which the "core" researchers publish, present, or participate in disciplinary venues. The field appears to have grown dramatically since 1995, from an estimated 5,000 health services researchers to an estimated 11,596 in 2007. This is a broad workforce characterized by various levels of involvement in the field. Some researchers self-identify with the field of HSR, while others are associated primarily with venues related to specific disciplines. Many researchers who identify with HSR also publish in venues related to multiple other disciplines. The field may face future challenges related to demographic change, such as an aging workforce and an increased need for diversity. International collaboration appears common, and in the future the field may need to be defined internationally rather than nationally. At the same time, there are also many indications that HSR is a good field to work in. Health services researchers reported high levels of satisfaction with their profession and current employer, as well as little desire to change jobs and little concern about job security.

  3. 78 FR 12422 - Health Services Research and Development Service Scientific Merit Review Board, Notice of Meeting

    Science.gov (United States)

    2013-02-22

    ... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit... nursing research. Applications are reviewed for scientific and technical merit, mission relevance, and the... Program Manager, Scientific Merit Review Board, Department of Veterans Affairs, Health Services Research...

  4. [Analogies and analogy research in technical biology and bionics].

    Science.gov (United States)

    Nachtigall, Werner

    2010-01-01

    The procedural approaches of Technical Biology and Bionics are characterized, and analogy research is identified as their common basis. The actual creative aspect in bionical research lies in recognizing and exploiting technically oriented analogies underlying a specific biological prototype to indicate a specific technical application.

  5. Research Collaboration Workshop for Women in Mathematical Biology

    CERN Document Server

    Miller, Laura

    2017-01-01

    Inspired by the Research Collaboration Workshop for Women in Mathematical Biology, this volume contains research and review articles that cover topics ranging from models of animal movement to the flow of blood cells in the embryonic heart. Hosted by the National Institute for Mathematics and Biological Synthesis (NIMBioS), the workshop brought together women working in biology and mathematics to form four research groups that encouraged multidisciplinary collaboration and lifetime connections in the STEM field. This volume introduces many of the topics from the workshop, including the aerodynamics of spider ballooning; sleep, circadian rhythms, and pain; blood flow regulation in the kidney; and the effects of antimicrobial therapy on gut microbiota and microbiota and Clostridium difficile. Perfect for students and researchers in mathematics and biology, the papers included in this volume offer an introductory glimpse at recent research in mathematical biology. .

  6. Analyzing Music Services Positioning Through Qualitative Research

    Directory of Open Access Journals (Sweden)

    Manuel Cuadrado

    2015-12-01

    Full Text Available Information technologies have produced new ways of distributing and consuming music, mainly by youth, in relation to both goods and services. In the case of goods, there has been a dramatic shift from traditional ways of buying and listening to music to new digital platforms. There has also been an evolution in relation to music services. In this sense, live music concerts have been losing their audiences over the past few years, as have music radio stations, in favor of streaming platforms. Curious about this phenomenon, we conducted an exploratory research in order to analyze how all these services, both traditional and new ones were perceived. Specifically, we aimed to study youth´s assessment of the three most relevant music service categories: music radio stations, digital streaming platforms, and pop-rock music festivals. To do so, we used the projective technique of image association to gather information. The population of the study consisted of individuals between 18 and 25 years of age. Our results, after using content analysis, were poor due to spontaneous recall. Therefore, we duplicated the study, but in a more focus-oriented way. Information gathered this time allowed us not only to better know how all these organizations are positioned but also to obtain a list of descriptors to be used in a subsequent descriptive research study.

  7. The RCSB Protein Data Bank: views of structural biology for basic and applied research and education.

    Science.gov (United States)

    Rose, Peter W; Prlić, Andreas; Bi, Chunxiao; Bluhm, Wolfgang F; Christie, Cole H; Dutta, Shuchismita; Green, Rachel Kramer; Goodsell, David S; Westbrook, John D; Woo, Jesse; Young, Jasmine; Zardecki, Christine; Berman, Helen M; Bourne, Philip E; Burley, Stephen K

    2015-01-01

    The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide. Our efforts over the past 2 years focused on enabling a deeper understanding of structural biology and providing new structural views of biology that support both basic and applied research and education. Herein, we describe recently introduced data annotations including integration with external biological resources, such as gene and drug databases, new visualization tools and improved support for the mobile web. We also describe access to data files, web services and open access software components to enable software developers to more effectively mine the PDB archive and related annotations. Our efforts are aimed at expanding the role of 3D structure in understanding biology and medicine. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  8. Accelerating cancer systems biology research through Semantic Web technology.

    Science.gov (United States)

    Wang, Zhihui; Sagotsky, Jonathan; Taylor, Thomas; Shironoshita, Patrick; Deisboeck, Thomas S

    2013-01-01

    Cancer systems biology is an interdisciplinary, rapidly expanding research field in which collaborations are a critical means to advance the field. Yet the prevalent database technologies often isolate data rather than making it easily accessible. The Semantic Web has the potential to help facilitate web-based collaborative cancer research by presenting data in a manner that is self-descriptive, human and machine readable, and easily sharable. We have created a semantically linked online Digital Model Repository (DMR) for storing, managing, executing, annotating, and sharing computational cancer models. Within the DMR, distributed, multidisciplinary, and inter-organizational teams can collaborate on projects, without forfeiting intellectual property. This is achieved by the introduction of a new stakeholder to the collaboration workflow, the institutional licensing officer, part of the Technology Transfer Office. Furthermore, the DMR has achieved silver level compatibility with the National Cancer Institute's caBIG, so users can interact with the DMR not only through a web browser but also through a semantically annotated and secure web service. We also discuss the technology behind the DMR leveraging the Semantic Web, ontologies, and grid computing to provide secure inter-institutional collaboration on cancer modeling projects, online grid-based execution of shared models, and the collaboration workflow protecting researchers' intellectual property. Copyright © 2012 Wiley Periodicals, Inc.

  9. Astroserver - Research Services in the Stellar Webshop

    Science.gov (United States)

    Németh, Péter

    2017-12-01

    A quick look at research and development in astronomy shows that we live in exciting times. Exoplanetary systems, supernovae, and merging binary black holes were far out of reach for observers two decades ago and now such phenomena are recorded routinely. This quick development would not have been possible without the ability for researchers to be connected, to think globally and to be mobile. Classical short-term positions are not always suitable to support these conditions and freelancing may be a viable alternative.We introduce the Astroserver framework, which is a new freelancing platform for scientists, and demonstrate through examples how it contributed to some recent projects related to hot subdwarf stars and binaries. These contributions, which included spectroscopic data mining, computing services and observing services, as well as artwork, allowed a deeper look into the investigated systems. The work on composite spectra binaries provided new details for the hypervelocity wide subdwarf binary PB 3877 and found diverse and rare systems with sub-giant companions in high-resolution spectroscopic surveys. The models for the peculiar abundance pattern of the evolved compact star LP 40-365 showed it to be a bound hypervelocity remnant of a supernova Iax event. Some of these works also included data visualizations to help presenting the new results. Such services may be of interest for many researchers.

  10. Dystrophin quantification: Biological and translational research implications.

    Science.gov (United States)

    Anthony, Karen; Arechavala-Gomeza, Virginia; Taylor, Laura E; Vulin, Adeline; Kaminoh, Yuuki; Torelli, Silvia; Feng, Lucy; Janghra, Narinder; Bonne, Gisèle; Beuvin, Maud; Barresi, Rita; Henderson, Matt; Laval, Steven; Lourbakos, Afrodite; Campion, Giles; Straub, Volker; Voit, Thomas; Sewry, Caroline A; Morgan, Jennifer E; Flanigan, Kevin M; Muntoni, Francesco

    2014-11-25

    We formed a multi-institution collaboration in order to compare dystrophin quantification methods, reach a consensus on the most reliable method, and report its biological significance in the context of clinical trials. Five laboratories with expertise in dystrophin quantification performed a data-driven comparative analysis of a single reference set of normal and dystrophinopathy muscle biopsies using quantitative immunohistochemistry and Western blotting. We developed standardized protocols and assessed inter- and intralaboratory variability over a wide range of dystrophin expression levels. Results from the different laboratories were highly concordant with minimal inter- and intralaboratory variability, particularly with quantitative immunohistochemistry. There was a good level of agreement between data generated by immunohistochemistry and Western blotting, although immunohistochemistry was more sensitive. Furthermore, mean dystrophin levels determined by alternative quantitative immunohistochemistry methods were highly comparable. Considering the biological function of dystrophin at the sarcolemma, our data indicate that the combined use of quantitative immunohistochemistry and Western blotting are reliable biochemical outcome measures for Duchenne muscular dystrophy clinical trials, and that standardized protocols can be comparable between competent laboratories. The methodology validated in our study will facilitate the development of experimental therapies focused on dystrophin production and their regulatory approval. © 2014 American Academy of Neurology.

  11. Current research in Radiation Biology and Biochemistry Division

    International Nuclear Information System (INIS)

    Tarachand, U.; Singh, B.B.

    1995-01-01

    The Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay has been engaged in research in the frontier areas of (i) radiation biology related to tumour therapy and injury caused by free radicals; (ii) molecular basis of diseases of physiological origin; (iii) molecular aspects of chemical carcinogenesis and (iv) structure of genome and genome related functions. The gist of research and development activities carried out in the Division during the last two years are documented

  12. Current research in Canada on biological effects of ionizing radiation

    International Nuclear Information System (INIS)

    Marko, A.M.

    1980-05-01

    A survey of current research in Canada on the biological effects of ionizing radiation has been compiled. The list of projects has been classified according to structure (organizational state of the test system) as well as according to the type of effects. Using several assumptions, ballpark estimates of expenditures on these activities have been made. Agencies funding these research activities have been tabulated and the break-down of research in government laboratories and in academic institutions has been designated. Wherever possible, comparisons have been made outlining differences or similarities that exist between the United States and Canada concerning biological radiation research. It has been concluded that relevant research in this area in Canada is inadequate. Wherever possible, strengths and weaknesses in radiation biology programs have been indicated. The most promising course for Canada to follow is to support adequately fundamental studies of the biological effects of radiation. (auth)

  13. Contribution to researches in biophysics and biology

    International Nuclear Information System (INIS)

    Luccioni, Catherine

    2000-01-01

    In this accreditation to supervise research, the author indicates its curriculum and scientific works which mainly dealt with the different agents used in chemotherapy. Scientific works addressed anti-carcinogenic pharmacology, applied biophysics, and researches in oncology and radiobiology. Current research projects deal with mechanisms of cellular transformation and the implication of the anti-oxidising metabolism and of nucleotide metabolism in cell radio-sensitivity. Teaching and research supervising activities are also indicated. Several articles are proposed in appendix: Average quality factor and dose equivalent meter based on microdosimetry techniques; Activity of thymidylate synthetase, thymidine kinase and galactokinase in primary and xenografted human colorectal cancers in relation to their chromosomal patterns; Nucleotide metabolism in human gliomas, relation to the chromosomal profile; Pyrimidine nucleotide metabolism in human colon carcinomas: comparison of normal tissues, primary tumors and xenografts; Modifications of the antioxidant metabolism during proliferation and differentiation of colon tumours cell lines; Modulation of the antioxidant enzymes, p21 and p53 expression during proliferation and differentiation of human melanoma cell lines; Purine metabolism in 2 human melanoma cell lines, relation with proliferation and differentiation; Radiation-induced changes in nucleotide metabolism of 2 colon cancer cell lines with different radio-sensitivities

  14. Teaching and research on Developmental Biology in Portugal.

    Science.gov (United States)

    Thorsteinsdóttir, Sólveig; Rodrigues, Gabriela; Crespo, Eduardo G

    2009-01-01

    Developmental Biology has established itself as a solid field of teaching and research in Portugal. Its history is recent, generally considered to have started with the pioneering work of Augusto Celestino da Costa at the beginning of the 20th century. However, research groups were very few and, until the early 1990s, teaching beyond morphological and comparative embryology was uncommon. In 1994, the first university course dedicated to Developmental Biology as a separate field from Embryology was created at the Faculty of Sciences of the University of Lisbon and a course on Plant Differentiation and Morphogenesis was also initiated. A Masters programme in Developmental Biology followed at the Lusofona University in 1996. Subsequently, modules of Developmental Biology were included in many Embryology courses and eventually more Developmental Biology courses were created. From 1999 onwards, the number of research groups working in Developmental Biology started to increase, many of which were initiated by researchers who had had the opportunity to pursue their PhD and/or post-doc studies abroad. The Instituto Gulbenkian de Cincia (Gulbenkian Institute of Science) became the first home of most of these groups, but several later spread to other institutions. This increased activity in turn has stimulated teaching of Developmental Biology and more students have been getting interested in the field. This positive feedback loop makes it a nice time to be teaching and working in Developmental Biology in Portugal.

  15. NCI RNA Biology 2017 symposium recap | Center for Cancer Research

    Science.gov (United States)

    The recent discovery of new classes of RNAs and the demonstration that alterations in RNA metabolism underlie numerous human cancers have resulted in enormous interest among CCR investigators in RNA biology. In order to share the latest research in this exciting field, the CCR Initiative in RNA Biology held its second international symposium April 23-24, 2017, in Natcher Auditorium. Learn more...

  16. Qualitative Methods in Mental Health Services Research

    Science.gov (United States)

    Palinkas, Lawrence A.

    2014-01-01

    Qualitative and mixed methods play a prominent role in mental health services research. However, the standards for their use are not always evident, especially for those not trained in such methods. This paper reviews the rationale and common approaches to using qualitative and mixed methods in mental health services and implementation research based on a review of the papers included in this special series along with representative examples from the literature. Qualitative methods are used to provide a “thick description” or depth of understanding to complement breadth of understanding afforded by quantitative methods, elicit the perspective of those being studied, explore issues that have not been well studied, develop conceptual theories or test hypotheses, or evaluate the process of a phenomenon or intervention. Qualitative methods adhere to many of the same principles of scientific rigor as quantitative methods, but often differ with respect to study design, data collection and data analysis strategies. For instance, participants for qualitative studies are usually sampled purposefully rather than at random and the design usually reflects an iterative process alternating between data collection and analysis. The most common techniques for data collection are individual semi-structured interviews, focus groups, document reviews, and participant observation. Strategies for analysis are usually inductive, based on principles of grounded theory or phenomenology. Qualitative methods are also used in combination with quantitative methods in mixed method designs for convergence, complementarity, expansion, development, and sampling. Rigorously applied qualitative methods offer great potential in contributing to the scientific foundation of mental health services research. PMID:25350675

  17. RESEARCH OF SERVICE QUALITY CUSTOMER SERVICES: PROBLEMS AND METHODOLOGY

    Directory of Open Access Journals (Sweden)

    Татьяна Анатольевна Оруч

    2014-05-01

    Full Text Available The article presents data from a study of the market of cellular communication of the Samara region and assess the quality of customer service by mobile operators for the period 2010-2012.Providing quality customer service is one of the major factors of competitiveness, enterprise services rendered. In a market economy, the problem of quality of service is the most important factor in improving the standard of living, economic, social and environmental security.The main problem in providing quality customer service system is that the formal criteria and evaluation methods used in the production sphere, do not apply to service businesses due to immateriality as a process of production and sales of services, and the service itself.The findings of the study conclusions and generalizations can be used in practice management companies providing public services provider.DOI: http://dx.doi.org/10.12731/2218-7405-2013-9-85

  18. Ecosystem Services in Biologically Diversified versus Conventional Farming Systems: Benefits, Externalities, and Trade-Offs

    Directory of Open Access Journals (Sweden)

    Claire Kremen

    2012-12-01

    Full Text Available We hypothesize that biological diversification across ecological, spatial, and temporal scales maintains and regenerates the ecosystem services that provide critical inputs - such as maintenance of soil quality, nitrogen fixation, pollination, and pest control - to agriculture. Agrobiodiversity is sustained by diversified farming practices and it also supplies multiple ecosystem services to agriculture, thus reducing environmental externalities and the need for off-farm inputs. We reviewed the literature that compares biologically diversified farming systems with conventional farming systems, and we examined 12 ecosystem services: biodiversity; soil quality; nutrient management; water-holding capacity; control of weeds, diseases, and pests; pollination services; carbon sequestration; energy efficiency and reduction of warming potential; resistance and resilience to climate change; and crop productivity. We found that compared with conventional farming systems, diversified farming systems support substantially greater biodiversity, soil quality, carbon sequestration, and water-holding capacity in surface soils, energy-use efficiency, and resistance and resilience to climate change. Relative to conventional monocultures, diversified farming systems also enhance control of weeds, diseases, and arthropod pests and they increase pollination services; however, available evidence suggests that these practices may often be insufficient to control pests and diseases or provide sufficient pollination. Significantly less public funding has been applied to agroecological research and the improvement of diversified farming systems than to conventional systems. Despite this lack of support, diversified farming systems have only somewhat reduced mean crop productivity relative to conventional farming systems, but they produce far fewer environmental and social harms. We recommend that more research and crop breeding be conducted to improve diversified farming

  19. 75 FR 53685 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2010-09-01

    ... 17, 2010, 8:30 a.m. to 12 p.m. ADDRESSES: Hilton Hotel, 620 Perry Parkway, Gaithersburg, MD 20877... the Climate Research Roadmap Workshop, BER Grand Challenge Workshop Report, and Systems Biology...

  20. Stable isotopes: essential tools in biological and medical research

    Energy Technology Data Exchange (ETDEWEB)

    Klein, P. D.; Hachey, D. L.; Kreek, M. J.; Schoeller, D. A.

    1977-01-01

    Recent developments in the use of the stable isotopes, /sup 13/C, /sup 15/N, /sup 17/O, and /sup 18/O, as tracers in research studies in the fields of biology, medicine, pharmacology, and agriculture are briefly reviewed. (CH)

  1. Biological Research in Canisters (BRIC) - Light Emitting Diode (LED)

    Science.gov (United States)

    Levine, Howard G.; Caron, Allison

    2016-01-01

    The Biological Research in Canisters - LED (BRIC-LED) is a biological research system that is being designed to complement the capabilities of the existing BRIC-Petri Dish Fixation Unit (PDFU) for the Space Life and Physical Sciences (SLPS) Program. A diverse range of organisms can be supported, including plant seedlings, callus cultures, Caenorhabditis elegans, microbes, and others. In the event of a launch scrub, the entire assembly can be replaced with an identical back-up unit containing freshly loaded specimens.

  2. 78 FR 50144 - Health Services Research and Development Service, Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2013-08-16

    ... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service, Scientific Merit... management, and nursing research. Applications are reviewed for scientific and technical merit, mission... Advisory Committee Act, 5 U.S.C. App. 2, that the Health Services Research and Development Service (HSR&D...

  3. Apparel Merchandising Students Learn Customer Service Strategies while Conducting Research.

    Science.gov (United States)

    Paulins, V, Ann

    2000-01-01

    Apparel merchandising students participated in a cooperative research project in which they observed customer service techniques by posing as customers in retail stores. The project taught research processes, collaboration, and principles of customer service. (SK)

  4. The laddering method in service innovation research

    DEFF Research Database (Denmark)

    Grünbaum, Niels Nolsøe

    2017-01-01

    map of what is actually going on in the consumer’s mind when the consumer is buying and consuming specific goods. It is argued, in this chapter, that this understanding is indeed both interesting and relevant in service innovation. More specifically, realizations of consumers’ values will help...... to guide marketers to understand what to innovate, how to innovate, how to plan and efficiently communicate changes, how to sell the innovations in the market place and how to implement organizational changes that innovations might cause. Furthermore, the laddering methodology has been applied across many...... fields with good success and the premises for using the method and for analyzing obtained data, is rather well described. The latter (i.e. premises and data analysis) is often raised as central and critical points of qualitative research methodology when arguing for problems with validity and reliability...

  5. Subject Didactic Studies of Research Training in Biology and Physics.

    Science.gov (United States)

    Lybeck, Leif

    1984-01-01

    The objectives and design of a 3-year study of research training and supervision in biology and physics are discussed. Scientific problems arising from work on the thesis will be a focus for the postgraduate students and their supervisors. Attention will be focused on supervisors' and students' conceptions of science, subject range, research,…

  6. Social justice and research using human biological material: A ...

    African Journals Online (AJOL)

    and provide that a person from whose body human biological material is withdrawn for research purposes may only be reimbursed for reasonable expenses incurred by him or her.[1,reg11] Accordingly, our law as it currently stands upholds an altruistic paradigm for participation in research and effectively outlaws any form ...

  7. Quarterly report of Biological and Medical Research Division, April 1955

    Energy Technology Data Exchange (ETDEWEB)

    Brues, A.M.

    1955-04-01

    This report is a compilation of 48 investigator prepared summaries of recent progress in individual research programs of the Biology and Medical Division of the Argonne National Laboratory for the quarterly period ending April,1955. Individual reports are about 3-6 pages in length and often contain research data.

  8. Service Users perspectives in PROMISE and research.

    Science.gov (United States)

    Rae, Sarah

    2017-09-01

    Since its inception in 2013, PROMISE (PROactive Management of Integrated Services and Environments) has been supporting service users and staff at the Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) on a journey to reduce reliance on force. The author's own personal experiences led to the founding of PROMISE and illustrates how individual experiences can influence a patient to lead change. Coproduction is actively embedded in PROMISE. Patients have been meaningfully involved because they are innovators and problem solvers who bring an alternative viewpoint by the very nature of their condition. A patient is more than just a person who needs to be 'fixed' they are individuals with untapped skills and added insight. There have been 2 separate Patient Advisory Groups (PAGs) since the project was first established. The first Patient Advisory Group was recruited to work with the PROMISE researchers on a study which used a participatory qualitative approach. Drawing on their lived experience and different perspectives the PAG was instrumental in shaping the qualitative study, including the research questions. Their active involvement helped to ensure that that the study was sensitively designed, methodologically robust and ethically sound. The 2 nd PAG was formed in 2016 to give the project an overall steer. Patients in this group contributed to the work on the 'No' Audit and reviewed several CPFT policies such as the Seclusion and Segregation policy which has impacted on frontline practice. They also made a significant contribution to the study design for a funding application that was submitted by the PROMISE team to the National Institute for Health Research (NIHR). Both PAGs were supported by funding from East of England Collaboration for Leadership in Applied Health Research and Care (CLAHRC EoE) and were influential in different ways. An evaluation of the 2 nd PAG which was conducted in June 2017 showed very high satisfaction levels. The free text

  9. Regional services in a research context: USDA climate hubs in the agricultural research service

    Science.gov (United States)

    Ten USDA Climate Hubs were created in 2014 to develop and deliver science-based, region-specific information and technologies to better enable agricultural decision-making and management. Of these ten Hubs, half are administered by USDA’s Agricultural Research Service (ARS), an agency with historica...

  10. Regional services in a research context: USDA Climate Hubs in the USDA Agricultural Research Service

    Science.gov (United States)

    Ten USDA Climate Hubs were created in 2014 to develop and deliver science-based, region-specific information and technologies to better enable agricultural decision-making and management. Of these ten Hubs, half are administered by USDA’s Agricultural Research Service (ARS), an agency with historica...

  11. [Health services research for the public health service (PHS) and the public health system].

    Science.gov (United States)

    Hollederer, A; Wildner, M

    2015-03-01

    There is a great need for health services research in the public health system and in the German public health service. However, the public health service is underrepresented in health services research in Germany. This has several structural, historical and disciplinary-related reasons. The public health service is characterised by a broad range of activities, high qualification requirements and changing framework conditions. The concept of health services research is similar to that of the public health service and public health system, because it includes the principles of multidisciplinarity, multiprofessionalism and daily routine orientation. This article focuses on a specified system theory based model of health services research for the public health system and public health service. The model is based on established models of the health services research and health system research, which are further developed according to specific requirements of the public health service. It provides a theoretical foundation for health services research on the macro-, meso- and microlevels in public health service and the public health system. Prospects for public health service are seen in the development from "old public health" to "new public health" as well as in the integration of health services research and health system research. There is a significant potential for development in a better linkage between university research and public health service as is the case for the "Pettenkofer School of Public Health Munich". © Georg Thieme Verlag KG Stuttgart · New York.

  12. Analysis of Nonstationary Time Series for Biological Rhythms Research.

    Science.gov (United States)

    Leise, Tanya L

    2017-06-01

    This article is part of a Journal of Biological Rhythms series exploring analysis and statistics topics relevant to researchers in biological rhythms and sleep research. The goal is to provide an overview of the most common issues that arise in the analysis and interpretation of data in these fields. In this article on time series analysis for biological rhythms, we describe some methods for assessing the rhythmic properties of time series, including tests of whether a time series is indeed rhythmic. Because biological rhythms can exhibit significant fluctuations in their period, phase, and amplitude, their analysis may require methods appropriate for nonstationary time series, such as wavelet transforms, which can measure how these rhythmic parameters change over time. We illustrate these methods using simulated and real time series.

  13. [Qualitative Research in Health Services Research - Discussion Paper, Part 3: Quality of Qualitative Research].

    Science.gov (United States)

    Stamer, M; Güthlin, C; Holmberg, C; Karbach, U; Patzelt, C; Meyer, T

    2015-12-01

    The third and final discussion paper of the German Network of Health Services Research's (DNVF) "Qualitative Methods Working Group" demonstrates methods for the evaluation and quality of qualitative research in health services research. In this paper we discuss approaches described in evaluating qualitative studies, including: an orientation to the general principles of empirical research, an approach-specific course of action, as well as procedures based on the research-process and criteria-oriented approaches. Divided into general and specific aspects to be considered in a qualitative study quality evaluation, the central focus of the discussion paper undertakes an extensive examination of the process and criteria-oriented approaches. The general aspects include the participation of relevant groups in the research process as well as ethical aspects of the research and data protection issues. The more specific aspects in evaluating the quality of qualitative research include considerations about the research interest, research questions, and the selection of data collection methods and types of analyses. The formulated questions are intended to guide reviewers and researchers to evaluate and to develop qualitative research projects appropriately. The intention of this discussion paper is to ensure a transparent research culture, and to reflect on and discuss the methodological and research approach of qualitative studies in health services research. With this paper we aim to initiate a discussion on high quality evaluation of qualitative health services research. © Georg Thieme Verlag KG Stuttgart · New York.

  14. Bringing the physical sciences into your cell biology research.

    Science.gov (United States)

    Robinson, Douglas N; Iglesias, Pablo A

    2012-11-01

    Historically, much of biology was studied by physicists and mathematicians. With the advent of modern molecular biology, a wave of researchers became trained in a new scientific discipline filled with the language of genes, mutants, and the central dogma. These new molecular approaches have provided volumes of information on biomolecules and molecular pathways from the cellular to the organismal level. The challenge now is to determine how this seemingly endless list of components works together to promote the healthy function of complex living systems. This effort requires an interdisciplinary approach by investigators from both the biological and the physical sciences.

  15. Biological and Physical Space Research Laboratory 2002 Science Review

    Science.gov (United States)

    Curreri, P. A. (Editor); Robinson, M. B. (Editor); Murphy, K. L. (Editor)

    2003-01-01

    With the International Space Station Program approaching core complete, our NASA Headquarters sponsor, the new Code U Enterprise, Biological and Physical Research, is shifting its research emphasis from purely fundamental microgravity and biological sciences to strategic research aimed at enabling human missions beyond Earth orbit. Although we anticipate supporting microgravity research on the ISS for some time to come, our laboratory has been vigorously engaged in developing these new strategic research areas.This Technical Memorandum documents the internal science research at our laboratory as presented in a review to Dr. Ann Whitaker, MSFC Science Director, in July 2002. These presentations have been revised and updated as appropriate for this report. It provides a snapshot of the internal science capability of our laboratory as an aid to other NASA organizations and the external scientific community.

  16. Linking Biological Responses of Terrestrial N Eutrophication to the Final Ecosystem Goods and Services Classification System

    Science.gov (United States)

    Bell, M. D.; Clark, C.; Blett, T.

    2015-12-01

    The response of a biological indicator to N deposition can indicate that an ecosystem has surpassed a critical load and is at risk of significant change. The importance of this exceedance is often difficult to digest by policy makers and public audiences if the change is not linked to a familiar ecosystem endpoint. A workshop was held to bring together scientists, resource managers, and policy makers with expertise in ecosystem functioning, critical loads, and economics in an effort to identify the ecosystem services impacted by air pollution. This was completed within the framework of the Final Ecosystem Goods and Services (FEGS) Classification System to produce a product that identified distinct interactions between society and the effects of nitrogen pollution. From each change in a biological indicator, we created multiple ecological production functions to identify the cascading effects of the change to a measureable ecosystem service that a user interacts with either by enjoying, consuming, or appreciating the good or service, or using it as an input in the human economy. This FEGS metric was then linked to a beneficiary group that interacts with the service. Chains detailing the links from the biological indicator to the beneficiary group were created for aquatic and terrestrial acidification and eutrophication at the workshop, and here we present a subset of the workshop results by highlighting for 9 different ecosystems affected by terrestrial eutrophication. A total of 213 chains that linked to 37 unique FEGS metrics and impacted 15 beneficiary groups were identified based on nitrogen deposition mediated changes to biological indicators. The chains within each ecosystem were combined in flow charts to show the complex, overlapping relationships among biological indicators, ecosystem services, and beneficiary groups. Strength of relationship values were calculated for each chain based on support for the link in the scientific literature. We produced the

  17. NASA Space Biology Plant Research for 2010-2020

    Science.gov (United States)

    Levine, H. G.; Tomko, D. L.; Porterfield, D. M.

    2012-01-01

    The U.S. National Research Council (NRC) recently published "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog.php?record id=13048), and NASA completed a Space Biology Science Plan to develop a strategy for implementing its recommendations ( http://www.nasa.gov/exploration/library/esmd documents.html). The most important recommendations of the NRC report on plant biology in space were that NASA should: (1) investigate the roles of microbial-plant systems in long-term bioregenerative life support systems, and (2) establish a robust spaceflight program of research analyzing plant growth and physiological responses to the multiple stimuli encountered in spaceflight environments. These efforts should take advantage of recently emerged analytical technologies (genomics, transcriptomics, proteomics, metabolomics) and apply modern cellular and molecular approaches in the development of a vigorous flight-based and ground-based research program. This talk will describe NASA's strategy and plans for implementing these NRC Plant Space Biology recommendations. New research capabilities for Plant Biology, optimized by providing state-of-the-art automated technology and analytical techniques to maximize scientific return, will be described. Flight experiments will use the most appropriate platform to achieve science results (e.g., ISS, free flyers, sub-orbital flights) and NASA will work closely with its international partners and other U.S. agencies to achieve its objectives. One of NASA's highest priorities in Space Biology is the development research capabilities for use on the International Space Station and other flight platforms for studying multiple generations of large plants. NASA will issue recurring NASA Research Announcements (NRAs) that include a rapid turn-around model to more fully engage the biology community in designing experiments to respond to the NRC recommendations. In doing so, NASA

  18. 77 FR 42365 - Health Services Research and Development Service Scientific Merit Review Board, Notice of Meeting

    Science.gov (United States)

    2012-07-18

    ... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that various subcommittees of the Health Services Research and Development Service Scientific Merit Review Board will meet on August 28-30, 2012, at the Boston Omni Parker...

  19. 77 FR 8330 - Health Services Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2012-02-14

    ... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that various subcommittees of the Health Services Research and Development Service Scientific Merit Review Board will meet on March 6-8, 2012, at the Hilton New Orleans...

  20. Activities in biological radiation research at the AGF

    International Nuclear Information System (INIS)

    1984-01-01

    The AGF is working on a wide spectrum of biological radiation research, with the different scientific disciplines contributing different methodologies to long-term research projects. The following fields are studied: 1. Molecular and cellular modes of action of radiation. 2. Detection and characterisation of biological radiation damage, especially in humans. 3. Medical applications of radiation effects. 4. Concepts and methods of radiation protection. The studies will lead to suggestions for radiation protection and improved radiotherapy. They may also contribute to the development of environmental protection strategies. (orig./MG) [de

  1. Recent Themes in Social Networking Service Research.

    Directory of Open Access Journals (Sweden)

    John S Liu

    Full Text Available The body of literature addressing the phenomenon related to social networking services (SNSs has grown rather fast recently. Through a systematic and quantitative approach, this study identifies the recent SNS research themes, which are the issues discussed by a coherent and growing subset of this literature. A set of academic articles retrieved from the Web of Science database is used as the basis for uncovering the recent themes. We begin the analysis by constructing a citation network which is further separated into groups after applying a widely used clustering method. The resulting clusters all consist of articles coherent in citation relationships. This study suggests eight fast growing recent themes. They span widely encompassing politics, romantic relationships, public relations, journalism, and health. Among them, four focus their issues largely on Twitter, three on Facebook, and one generally on both. While discussions on traditional issues in SNSs such as personality, motivations, self-disclosure, narcissism, etc. continue to lead the pack, the proliferation of the highlighted recent themes in the near future is very likely to happen.

  2. Recent Themes in Social Networking Service Research.

    Science.gov (United States)

    Liu, John S; Ho, Mei Hsiu-Ching; Lu, Louis Y Y

    2017-01-01

    The body of literature addressing the phenomenon related to social networking services (SNSs) has grown rather fast recently. Through a systematic and quantitative approach, this study identifies the recent SNS research themes, which are the issues discussed by a coherent and growing subset of this literature. A set of academic articles retrieved from the Web of Science database is used as the basis for uncovering the recent themes. We begin the analysis by constructing a citation network which is further separated into groups after applying a widely used clustering method. The resulting clusters all consist of articles coherent in citation relationships. This study suggests eight fast growing recent themes. They span widely encompassing politics, romantic relationships, public relations, journalism, and health. Among them, four focus their issues largely on Twitter, three on Facebook, and one generally on both. While discussions on traditional issues in SNSs such as personality, motivations, self-disclosure, narcissism, etc. continue to lead the pack, the proliferation of the highlighted recent themes in the near future is very likely to happen.

  3. Applying the community partnership approach to human biology research.

    Science.gov (United States)

    Ravenscroft, Julia; Schell, Lawrence M; Cole, Tewentahawih'tha'

    2015-01-01

    Contemporary human biology research employs a unique skillset for biocultural analysis. This skillset is highly appropriate for the study of health disparities because disparities result from the interaction of social and biological factors over one or more generations. Health disparities research almost always involves disadvantaged communities owing to the relationship between social position and health in stratified societies. Successful research with disadvantaged communities involves a specific approach, the community partnership model, which creates a relationship beneficial for researcher and community. Paramount is the need for trust between partners. With trust established, partners share research goals, agree on research methods and produce results of interest and importance to all partners. Results are shared with the community as they are developed; community partners also provide input on analyses and interpretation of findings. This article describes a partnership-based, 20 year relationship between community members of the Akwesasne Mohawk Nation and researchers at the University at Albany. As with many communities facing health disparity issues, research with Native Americans and indigenous peoples generally is inherently politicized. For Akwesasne, the contamination of their lands and waters is an environmental justice issue in which the community has faced unequal exposure to, and harm by environmental toxicants. As human biologists engage in more partnership-type research, it is important to understand the long term goals of the community and what is at stake so the research circle can be closed and 'helicopter' style research avoided. © 2014 Wiley Periodicals, Inc.

  4. 78 FR 6854 - Health Services Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2013-01-31

    ... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Scientific Merit... Research and Development Service Scientific Merit Review Board will meet on February 13-14, 2013, at the... research. Applications are reviewed for scientific and technical merit. Recommendations regarding funding...

  5. Conceptions of the Nature of Science Held by Undergraduate Pre-Service Biology Teachers in South-West Nigeria

    Science.gov (United States)

    Adedoyin, A. O.; Bello, G.

    2017-01-01

    This study investigated the conceptions of the nature of science held by pre-service undergraduate biology teachers in South-West, Nigeria. Specifically, the study examined the influence of their gender on their conceptions of the nature of science. The study was a descriptive research of the survey method. The population for the study comprised…

  6. The experiences of health services research and health services research training in Korea.

    Science.gov (United States)

    Moon, O R

    1984-12-01

    Early in the 1970s the Korean government recognized the necessity of Health Services Research (HSR). The law of the Korea Health Development Institute was promulgated in 1975, and a contribution from the Republic was combined with an Agency for International Development loan to field test low-cost health service strategies. A program to deploy Community Health Practitioners (CHPs), similar to family nurse practitioners or Medex has been demonstrated to be effective. The CHP training program grew from 9 in 1980 to 1343 in 1984. CHP's main functions are curative, preventive, educative, and administrative. They are selected registered nurses and/or midwives, where possible from serviced communities. They are trained in 24 weeks, including 12 weeks of clinical practice, in an anticipated recruiting post. CHPs help train village health volunteers (VHVs), who are literate women chosen by their communities. They work closely with the CHPs as a liaison with the village and in information gathering. An HSR orientation workshop held in Chuncheon in 1980, discussed role, policy, status, finance components, information systems, behavioral and manpower components, staff training, protocols for project development, HSR in the future and evaluation of the conference. In 1980, a National Workshop on Biomedical Research Methodology was also held, with World Health Organization and Korean consultants. Training of junior scientists would include introduction to scientific method, statement of problems, quantitative study technics, research proposals, and interpretation of results. The Korean Institute of Public Health sponsored a 1982 experts forum on the health care system, medical facilities, organizational management, financing and medical security, and health behavioral aspects. Training of trainers and lower level field workers, orientation of program managers, researchers, and communities themselves should all be training priorities. In future, CHPs should be refresher

  7. Bibliographical review on the teaching of Biology and research

    Directory of Open Access Journals (Sweden)

    Mª Luz Rodríguez Palmero

    2000-09-01

    Full Text Available This review complements another one done by the same author, in 1997, regarding the role of comprehending the concept of cell in the learning of Biology. In addition, some general papers on science education that provide a better understanding of research approaches used in the investigation of this topic have been included. The reviewed papers have been organized into categories according to the object of study, the relevance assigned to the cell concept, and the framework of analysis. The review shows that the concept of cell is very important in the biological conceptualization, however, it also shows the need of additional research on this matter, from theoretical frameworks that pay more attention to the psychological level, in order to provide some guidance to improve the teaching and learning processes of the biological content that presupose the comprehension of living beings.

  8. Biological field stations: research legacies and sites for serendipity

    Science.gov (United States)

    William K. Michener; Keith L. Bildstein; Arthur McKee; Robert R. Parmenter; William W. Hargrove; Deedra McClearn; Mark Stromberg

    2009-01-01

    Biological field stations are distributed throughout North America, capturing much of the ecological variability present at the continental scale and encompassing many unique habitats. In addition to their role in supporting research and education, field stations offer legacies of data, specimens, and accumulated knowledge. Such legacies often provide the only...

  9. Cancer systems biology: signal processing for cancer research

    Science.gov (United States)

    Yli-Harja, Olli; Ylipää, Antti; Nykter, Matti; Zhang, Wei

    2011-01-01

    In this editorial we introduce the research paradigms of signal processing in the era of systems biology. Signal processing is a field of science traditionally focused on modeling electronic and communications systems, but recently it has turned to biological applications with astounding results. The essence of signal processing is to describe the natural world by mathematical models and then, based on these models, develop efficient computational tools for solving engineering problems. Here, we underline, with examples, the endless possibilities which arise when the battle-hardened tools of engineering are applied to solve the problems that have tormented cancer researchers. Based on this approach, a new field has emerged, called cancer systems biology. Despite its short history, cancer systems biology has already produced several success stories tackling previously impracticable problems. Perhaps most importantly, it has been accepted as an integral part of the major endeavors of cancer research, such as analyzing the genomic and epigenomic data produced by The Cancer Genome Atlas (TCGA) project. Finally, we show that signal processing and cancer research, two fields that are seemingly distant from each other, have merged into a field that is indeed more than the sum of its parts. PMID:21439242

  10. Biologically Enhanced Carbon Sequestration: Research Needs and Opportunities

    Energy Technology Data Exchange (ETDEWEB)

    Oldenburg, Curtis; Oldenburg, Curtis M.; Torn, Margaret S.

    2008-03-21

    Fossil fuel combustion, deforestation, and biomass burning are the dominant contributors to increasing atmospheric carbon dioxide (CO{sub 2}) concentrations and global warming. Many approaches to mitigating CO{sub 2} emissions are being pursued, and among the most promising are terrestrial and geologic carbon sequestration. Recent advances in ecology and microbial biology offer promising new possibilities for enhancing terrestrial and geologic carbon sequestration. A workshop was held October 29, 2007, at Lawrence Berkeley National Laboratory (LBNL) on Biologically Enhanced Carbon Sequestration (BECS). The workshop participants (approximately 30 scientists from California, Illinois, Oregon, Montana, and New Mexico) developed a prioritized list of research needed to make progress in the development of biological enhancements to improve terrestrial and geologic carbon sequestration. The workshop participants also identified a number of areas of supporting science that are critical to making progress in the fundamental research areas. The purpose of this position paper is to summarize and elaborate upon the findings of the workshop. The paper considers terrestrial and geologic carbon sequestration separately. First, we present a summary in outline form of the research roadmaps for terrestrial and geologic BECS. This outline is elaborated upon in the narrative sections that follow. The narrative sections start with the focused research priorities in each area followed by critical supporting science for biological enhancements as prioritized during the workshop. Finally, Table 1 summarizes the potential significance or 'materiality' of advances in these areas for reducing net greenhouse gas emissions.

  11. Biological/paleoecological analysis for modern archaeological research

    International Nuclear Information System (INIS)

    Berglund, B.E.

    1977-01-01

    The importance of biological/geological methods besides geophysical/chemical ones for a multidisciplinary archaeological research is underlined. This is a necessity for a deeper knowledge of prehistoric society, settlement environment and the human landscape development. Dating methods are discussed and archaeological/paleoecological settlement studies are illustrated by a generalized case study. A proposed organization in Sweden of the research cooperation between archaeologists and natural science specialists is also discussed. (author)

  12. When public services fail: A research agenda on public service failure

    OpenAIRE

    Van de Walle, Steven

    2016-01-01

    Purpose This paper reviews the literature on public service failure and develops a research agenda for studying public service failure alongside private service failure. The general services management literature has devoted relatively little attention to public services, whereas developments in the private service management literature have not reached public management. Design/methodology/approach This is a conceptual paper, drawing on the public management literature. Differen...

  13. Stem Cells: A Renaissance in Human Biology Research.

    Science.gov (United States)

    Wu, Jun; Izpisua Belmonte, Juan Carlos

    2016-06-16

    The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. The solar system: Importance of research to the biological sciences

    Science.gov (United States)

    Klein, Harold P.

    1992-01-01

    An attempt is made to describe the scope of scientific areas that comprise the current field of exobiology in the United States. From investigations of astrophysical phenomena that deal with the birth of stars and planetary systems to questions of molecular biology involving phylogenetic relationships among organisms, from attempts to simulate the synthesis of biological precursor molecules in the chemistry laboratory to making measurements of the organic constituents of Titan's atmosphere, these researches all converge toward a common objective--answering the question of how life came about in the universe.

  15. Service quality in alcohol treatment: a research note.

    Science.gov (United States)

    Resnick, Sheilagh M; Griffiths, Mark D

    2011-01-01

    The purpose of this paper is to evaluate service quality in a UK privately funded alcohol treatment clinic. Data were gathered via interviews with two groups of participants using the SERVQUAL questionnaire. The first group comprised 32 patients and the second 15 clinic staff. The SERVQUAL instrument measures service quality expectations and perceptions across five service dimensions and identifies gaps between service expectations and perceptions of what was delivered. Patients' service quality expectations were exceeded on four of five dimensions. However, staff members felt services fell below expectations on four of five dimensions with the "reliability" service dimension emerging as the common service element falling below expectations for both participant groups. It was concluded that achieving consistent service delivery and increasing empathy between staff and patients improves overall service quality perceptions. The paper relies on self-report methods from a relatively small number of individuals. There have been limited research studies measuring alcohol treatment service quality in the private sector.

  16. 76 FR 42168 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2011-07-18

    ... testing of new methods of health care delivery and management, and nursing research. Applications are... Research and Development Officer. On August 30, the subcommittees on Nursing Research Initiatives and... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board...

  17. Invited Review Article: Advanced light microscopy for biological space research

    Energy Technology Data Exchange (ETDEWEB)

    De Vos, Winnok H., E-mail: winnok.devos@uantwerpen.be [Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Antwerp (Belgium); Cell Systems and Imaging Research Group, Department of Molecular Biotechnology, Ghent University, Ghent (Belgium); Beghuin, Didier [Lambda-X, Nivelles (Belgium); Schwarz, Christian J. [European Space Agency (ESA), ESTEC, TEC-MMG, Noordwijk (Netherlands); Jones, David B. [Institute for Experimental Orthopaedics and Biomechanics, Philipps University, Marburg (Germany); Loon, Jack J. W. A. van [Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center and Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam, Amsterdam (Netherlands); Bereiter-Hahn, Juergen; Stelzer, Ernst H. K. [Physical Biology, BMLS (FB15, IZN), Goethe University, Frankfurt am Main (Germany)

    2014-10-15

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  18. Invited Review Article: Advanced light microscopy for biological space research

    Science.gov (United States)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; van Loon, Jack J. W. A.; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  19. Invited Review Article: Advanced light microscopy for biological space research

    International Nuclear Information System (INIS)

    De Vos, Winnok H.; Beghuin, Didier; Schwarz, Christian J.; Jones, David B.; Loon, Jack J. W. A. van; Bereiter-Hahn, Juergen; Stelzer, Ernst H. K.

    2014-01-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy

  20. Invited review article: Advanced light microscopy for biological space research.

    Science.gov (United States)

    De Vos, Winnok H; Beghuin, Didier; Schwarz, Christian J; Jones, David B; van Loon, Jack J W A; Bereiter-Hahn, Juergen; Stelzer, Ernst H K

    2014-10-01

    As commercial space flights have become feasible and long-term extraterrestrial missions are planned, it is imperative that the impact of space travel and the space environment on human physiology be thoroughly characterized. Scrutinizing the effects of potentially detrimental factors such as ionizing radiation and microgravity at the cellular and tissue level demands adequate visualization technology. Advanced light microscopy (ALM) is the leading tool for non-destructive structural and functional investigation of static as well as dynamic biological systems. In recent years, technological developments and advances in photochemistry and genetic engineering have boosted all aspects of resolution, readout and throughput, rendering ALM ideally suited for biological space research. While various microscopy-based studies have addressed cellular response to space-related environmental stressors, biological endpoints have typically been determined only after the mission, leaving an experimental gap that is prone to bias results. An on-board, real-time microscopical monitoring device can bridge this gap. Breadboards and even fully operational microscope setups have been conceived, but they need to be rendered more compact and versatile. Most importantly, they must allow addressing the impact of gravity, or the lack thereof, on physiologically relevant biological systems in space and in ground-based simulations. In order to delineate the essential functionalities for such a system, we have reviewed the pending questions in space science, the relevant biological model systems, and the state-of-the art in ALM. Based on a rigorous trade-off, in which we recognize the relevance of multi-cellular systems and the cellular microenvironment, we propose a compact, but flexible concept for space-related cell biological research that is based on light sheet microscopy.

  1. Cytogenetic Analysis for Research and Services

    Directory of Open Access Journals (Sweden)

    Sultana MH Faradz

    2017-02-01

    malignancy is indicated to support diagnosis, select therapy regimen, and elaborate prognosis. Specific chromosome translocations have been identified for hematologic malignancy. The breakpoints of several of these translocations have been cloned. Several loci of oncogene have been identified and sequenced.  Molecular genetic analysis will replace cytogenetic analysis and shift the requirement for studying metaphase cells. Therefore, chromosome analysis in genetic disease and cancer should be attained with advanced molecular techniques, such as Fluorescence In Situ Hybridization (FISH and microarray CGH analysis.  Cytogenetic analysis is still useful and applicable in genetic disease diagnosis, sexual assignment, and hematologic malignancy in the laboratory with minimal equipments. Molecular analysis as a part of health care services in Indonesia has been limited in research centers in university setting; therefore, a comprehensive diagnosis with genetic analysis has often been improbable. Keywords: cytogenetics, chromosome, syndrome, DSD, hematologic malignancy

  2. pClone: Synthetic Biology Tool Makes Promoter Research Accessible to Beginning Biology Students

    Science.gov (United States)

    Eckdahl, Todd; Cronk, Brian; Andresen, Corinne; Frederick, Paul; Huckuntod, Samantha; Shinneman, Claire; Wacker, Annie; Yuan, Jason

    2014-01-01

    The Vision and Change report recommended genuine research experiences for undergraduate biology students. Authentic research improves science education, increases the number of scientifically literate citizens, and encourages students to pursue research. Synthetic biology is well suited for undergraduate research and is a growing area of science. We developed a laboratory module called pClone that empowers students to use advances in molecular cloning methods to discover new promoters for use by synthetic biologists. Our educational goals are consistent with Vision and Change and emphasize core concepts and competencies. pClone is a family of three plasmids that students use to clone a new transcriptional promoter or mutate a canonical promoter and measure promoter activity in Escherichia coli. We also developed the Registry of Functional Promoters, an open-access database of student promoter research results. Using pre- and posttests, we measured significant learning gains among students using pClone in introductory biology and genetics classes. Student posttest scores were significantly better than scores of students who did not use pClone. pClone is an easy and affordable mechanism for large-enrollment labs to meet the high standards of Vision and Change. PMID:26086659

  3. Research Issues in the Next Generation Group Communication Services

    National Research Council Canada - National Science Library

    Mishra, Shivakart

    2000-01-01

    The main objective of the proposed research was to investigate five important practical issues iii the design of high performance, heterogeneous group communication services for constructing the next...

  4. Research Applications of Proteolytic Enzymes in Molecular Biology

    Directory of Open Access Journals (Sweden)

    József Tőzsér

    2013-11-01

    Full Text Available Proteolytic enzymes (also termed peptidases, proteases and proteinases are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications require their use, including production of Klenow fragments, peptide synthesis, digestion of unwanted proteins during nucleic acid purification, cell culturing and tissue dissociation, preparation of recombinant antibody fragments for research, diagnostics and therapy, exploration of the structure-function relationships by structural studies, removal of affinity tags from fusion proteins in recombinant protein techniques, peptide sequencing and proteolytic digestion of proteins in proteomics. The aim of this paper is to review the molecular biological aspects of proteolytic enzymes and summarize their applications in the life sciences.

  5. Teaching Qualitative Research Methods through Service-Learning

    Science.gov (United States)

    Machtmes, Krisanna; Johnson, Earl; Fox, Janet; Burke, Mary S.; Harper, Jeannie; Arcemont, Lisa; Hebert, Lanette; Tarifa, Todd; Brooks, Roy C., Jr.; Reynaud, Andree L.; Deggs, David; Matzke, Brenda; Aguirre, Regina T. P.

    2009-01-01

    This paper is the result of a voluntary service-learning component in a qualitative research methods course. For this course, the service-learning project was the evaluation of the benefits to volunteers who work a crisis hotline for a local crisis intervention center. The service-learning course model used in this paper most closely resembles the…

  6. BRIC-60: Biological Research in Canisters (BRIC)-60

    Science.gov (United States)

    Richards, Stephanie E. (Compiler); Levine, Howard G.; Romero, Vergel

    2016-01-01

    The Biological Research in Canisters (BRIC) is an anodized-aluminum cylinder used to provide passive stowage for investigations evaluating the effects of space flight on small organisms. Specimens flown in the BRIC 60 mm petri dish (BRIC-60) hardware include Lycoperscion esculentum (tomato), Arabidopsis thaliana (thale cress), Glycine max (soybean) seedlings, Physarum polycephalum (slime mold) cells, Pothetria dispar (gypsy moth) eggs and Ceratodon purpureus (moss).

  7. Research Applications of Proteolytic Enzymes in Molecular Biology

    OpenAIRE

    Mótyán, János András; Tóth, Ferenc; Tőzsér, József

    2013-01-01

    Proteolytic enzymes (also termed peptidases, proteases and proteinases) are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic enzymes have great medical and pharmaceutical importance due to their key role in biological processes and in the life-cycle of many pathogens. Proteases are extensively applied enzymes in several sectors of industry and biotechnology, furthermore, numerous research applications ...

  8. WEB MAPPING SERVICES FOR RESEARCH NATURAL HAZARDS

    Directory of Open Access Journals (Sweden)

    R. K. Abdullin

    2016-01-01

    Full Text Available The article presents a description of the use modern technologies of web mapping to explore natural hazards (primarily hydrometeorological. The examples of Russian and foreign cartographic web services created for solving tasks of monitoring and mapping of such phenomena and caused by them of emergency situations, and also objectives of their monitoring and forecasting.

  9. Research support services for IDRC grantees

    International Development Research Centre (IDRC) Digital Library (Canada)

    Melanie Brunet

    Authoritative research literaturethrough a collection of commercial research databases covering multiple disciplines and subscriptions to electronic journals. Contact researchsupport@idrc.ca to receive your username and password. Research help:The Librarian can… • Assist you in defining search strategies (key concepts ...

  10. Biological and chemical technologies research. FY 1995 annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    None

    1996-03-01

    The annual summary report presents the fiscal year (FY) 1995 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program. This BCTR program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1995 (ASR 95) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1995; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents; and awards arising from work supported by the BCTR.

  11. A strategy for building public service motivation research Internationally

    NARCIS (Netherlands)

    Kim, S.; Vandenabeele, W.V.

    2010-01-01

    As public service motivation research grows qualitatively and quantitatively, some scholars question its appropriateness for international applications. This essay sets out a strategy of convergence for international research and measurement approaches. Studies that assess commonalities in public

  12. Division of Biological and Medical Research annual technical report, 1981

    International Nuclear Information System (INIS)

    Rosenthal, M.W.

    1982-06-01

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies

  13. Division of Biological and Medical Research annual technical report, 1981

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1982-06-01

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Research in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

  14. 76 FR 6197 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2011-02-03

    ... management, and nursing research. Applications are reviewed for scientific and technical merit... subcommittee on Nursing Research Initiatives will convene from 8 a.m. to 2 p.m.; the subcommittee for pilot... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board...

  15. 75 FR 39734 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-07-12

    ... management, and nursing research. Applications are reviewed for scientific and technical merit... subcommittee on Nursing Research Initiative will convene from 8 a.m. to 2 p.m. and Career Development Award... DEPARTMENT OF VETERANS AFFAIRS Health Services Research and Development Service Merit Review Board...

  16. Bioremediation of oil contaminated soil from service stations. Evaluation of biological treatment

    International Nuclear Information System (INIS)

    Puustinen, J.; Jorgensen, K.S.; Strandberg, T.; Suortti, A.M.

    1995-01-01

    Biological treatment of contaminated soil has received much attention during the last decade. Microbes are known to be able to degrade many oil hydrocarbons. However, research is needed to ensure that new technologies are implemented in a safe and reliable way under Finnish climatic conditions. The main points of interest are the rate of the degradation as well as the survival and efficiency of microbial inoculants possibly introduced during the treatment. During 1993 the biotreatability of oil-contaminated soil from service stations was investigated in cooperation with the Finnish Petroleum Federation. The goal of this field-scale study was to test how fast lubrication oil can be composted during one Finnish summer season and to find out whether microbial inoculants would enhance the degradation rate. The soil was excavated from three different service stations in the Helsinki metropolitan area and was transported to a controlled composting area. The soil was sieved and compost piles, also called biopiles, were constructed on the site. Bark chips were used as the bulking agent and nutrients and lime were added to enhance the biological activity. Two different commercial bacterial inoculants were added to two of the piles. The piles were turned by a tractor-drawn screw-type mixer at two to four weeks interval. Between the mixings, the piles were covered with tarpaulins to prevent evaporation and potential excessive wetting. Several microbiological parameters were determined during the test period as well as the temperature and mineral oil content

  17. Ecosystem services – current challenges and opportunities for ecological research

    Directory of Open Access Journals (Sweden)

    Klaus eBirkhofer

    2015-01-01

    Full Text Available The concept of ecosystem services was originally developed to illustrate the benefits that natural ecosystems generate for society and to raise awareness for biodiversity and ecosystem conservation. In this article we identify major challenges and opportunities for ecologists involved in empirical or modeling ecosystem service research. The first challenge arises from the fact that the ecosystem service concept has not been generated in the context of managed systems. Ecologists need to identify the effect of anthropogenic interventions in order to propose practices to benefit service-providing organisms and associated services. The second challenge arises from the need to evaluate relationships between indicators of ecosystem services that are collected in ecological studies while accounting for uncertainties of ecological processes that underlie these services. We suggest basing the assessment of ecosystem services on the utilization of sets of indicators that cover aspects of service-providing units, ecosystem management and landscape modification. The third challenge arises from our limited understanding of the nature of relationships between services and a lack of a general statistical framework to address these links. To manage ecosystem service provisioning, ecologists need to establish whether services respond to a shared driver or if services are directly linked to each other. Finally, studies relating biodiversity to ecosystem services often focus on services at small spatial or short temporal scales, but research on the protection of services is often directed towards services providing benefits at large spatial scales. Ecological research needs to address a range of spatial and temporal scales to provide a multifaceted understanding of how nature promotes human well-being. Addressing these challenges in the future offers a unique opportunity for ecologists to act as promoters for the understanding about how to conserve benefits

  18. Division of Biological and Medical Research research summary 1984-1985

    Energy Technology Data Exchange (ETDEWEB)

    Barr, S.H. (ed.)

    1985-08-01

    The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group.

  19. Division of Biological and Medical Research research summary 1984-1985

    International Nuclear Information System (INIS)

    Barr, S.H.

    1985-08-01

    The Division of Biological and Medical Research at Argonne National Laboratory conducts multidisciplinary research aimed at defining the biological and medical hazards to man from energy technologies and new energy options. These technically oriented studies have a strong base in fundamental research in a variety of scientific disciplines, including molecular and cellular biology, biophysics, genetics, radiobiology, pharmacology, biochemistry, chemistry, environmental toxicology, and epidemiology. This research summary is organized into six parts. The first five parts reflect the Divisional structure and contain the scientific program chapters, which summarize the activities of the individual groups during the calendar year 1984 and the first half of 1985. To provide better continuity and perspective, previous work is sometimes briefly described. Although the summaries are short, efforts have been made to indicate the range of research activities for each group

  20. use of library and information services for legislative research

    African Journals Online (AJOL)

    Elizabeth

    Keywords: Legislature, National Assembly, Library services, Legislative research, Information. Introduction. Information has ... offers core services for learning and research. It plays the role of support to the legislative learning .... Nisbet ,J and Schucksmith (1986) Learning strategies. London: Rutledge and Kegan Paul.

  1. Framing design research for service orientation through PSS approaches

    DEFF Research Database (Denmark)

    Sakao, Tomohiko; Sandström, Gunilla Ölundh; Matzen, Detlef

    2009-01-01

    on the literature analysis, the authors present three crucial dimensions for service oriented design research, i.e. an offer dimension representing products and services, a provider dimension, and a customer/user dimension. In addition, three research targets are proposed; PSS-offer modelling, PSS development...

  2. Delivering research data management services fundamentals of good practice

    CERN Document Server

    Jones, Sarah; Whyte, Angus

    2014-01-01

    The research landscape is changing, with key global research funders now requiring institutions to demonstrate how they will preserve and share research data. However, the practice of structured research data management is very new, and the construction of services remains experimental and in need of models and standards of approach. This groundbreaking guide will lead researchers, institutions and policy makers through the processes needed to set up and run effective institutional research data management services. This book will provide a step-by-step explanation of the components for an institutional service - effectively a 'how to guide'. Case studies from the newly emerging service infrastructures in the UK, USA and Australia will draw out the lessons learnt from working (or near to delivery) exemplars. Different approaches are highlighted and compared, for example, a case study of a researcher-focused strategy from Australia contrasted with a national, top-down approach. A chapter on the redeveloped UK ...

  3. Portraying Reflexivity in Health Services Research.

    Science.gov (United States)

    Rae, John; Green, Bill

    2016-09-01

    A model is proposed for supporting reflexivity in qualitative health research, informed by arguments from Bourdieu and Finlay. Bourdieu refers to mastering the subjective relation to the object at three levels-the overall social space, the field of specialists, and the scholastic universe. The model overlays Bourdieu's levels of objectivation with Finlay's three stages of research (pre-research, data collection, and data analysis). The intersections of these two ways of considering reflexivity, displayed as cells of a matrix, pose questions and offer prompts to productively challenge health researchers' reflexivity. Portraiture is used to show how these challenges and prompts can facilitate such reflexivity, as illustrated in a research project. © The Author(s) 2016.

  4. Division of Biological and Medical Research annual report 1978

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1978-01-01

    The research during 1978 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Studies related to nuclear energy include responses of beagles to continuous low-level /sup 60/Co gamma radiation, and development of leukemic indicators; comparison of lifetime effects in mice of low-level neutron and /sup 60/Co gamma radiation; genetic effects of high LET radiations; and metabolic and therapeutic studies of heavy metals. Studies of nonnuclear energy sources deal with characterization and toxicological evaluation of effluents of fluidized bed combustion and coal gasification; electrical storage systems; electric fields associated with energy transmission; and development of population projection models and assessment of human risk. Basic research studies include fundamental structural and biophysical investigations; circadian rhythms; mutagenesis in bacteria and mammalian cells; cell killing, damage, and repair in mammalian cells; carcinogenesis and cocarcinogenesis; the use of liposomes as biological carriers; and studies of environmental influences on life-span, physiological performance, and circadian cycles. In the area of medical development, proteins in urine and tissues of normal and diseased humans are analyzed, and advanced analytical procedures for use of stable isotopes in clinical research and diagnosis are developed and applied. The final sections of the report cover support facilities, educational activities, the seminar program, staff talks, and staff publications.

  5. Division of Biological and Medical Research annual technical report 1982

    Energy Technology Data Exchange (ETDEWEB)

    Rosenthal, M.W. (ed.)

    1983-05-01

    This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the genetic effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

  6. Division of Biological and Medical Research annual technical report 1982

    International Nuclear Information System (INIS)

    Rosenthal, M.W.

    1983-05-01

    This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the genetic effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies

  7. Division of Biological and Medical Research annual report 1978

    International Nuclear Information System (INIS)

    Rosenthal, M.W.

    1978-01-01

    The research during 1978 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Studies related to nuclear energy include responses of beagles to continuous low-level 60 Co gamma radiation, and development of leukemic indicators; comparison of lifetime effects in mice of low-level neutron and 60 Co gamma radiation; genetic effects of high LET radiations; and metabolic and therapeutic studies of heavy metals. Studies of nonnuclear energy sources deal with characterization and toxicological evaluation of effluents of fluidized bed combustion and coal gasification; electrical storage systems; electric fields associated with energy transmission; and development of population projection models and assessment of human risk. Basic research studies include fundamental structural and biophysical investigations; circadian rhythms; mutagenesis in bacteria and mammalian cells; cell killing, damage, and repair in mammalian cells; carcinogenesis and cocarcinogenesis; the use of liposomes as biological carriers; and studies of environmental influences on life-span, physiological performance, and circadian cycles. In the area of medical development, proteins in urine and tissues of normal and diseased humans are analyzed, and advanced analytical procedures for use of stable isotopes in clinical research and diagnosis are developed and applied. The final sections of the report cover support facilities, educational activities, the seminar program, staff talks, and staff publications

  8. Common data manipulations with R in biological researches.

    Science.gov (United States)

    Chen, Shi-Yi; Liu, Qin; Feng, Zhe

    2017-07-01

    R is a computer language and has been widely used in science community due to the powerful capability in data analysis and visualization; and these functions are mainly provided by the developed packages. Because every package has strict format definitions on the inputted data, it is always required to appropriately manipulate the original data in advance. Unfortunately, users, especially for the beginners, are always confused by the extreme flexibility with R in data manipulation. In the present paper, we roughly categorize the common manipulations with R for biological data into four classes, including overview of data, transformation, summarization, and reshaping. Subsequently, these manipulations are exemplified in a sample data of clinical records of diabetic patients. Our main purpose is to provide a better landscape on the data manipulation with R and hence facilitate the practical applications in biological researches.

  9. Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

    Directory of Open Access Journals (Sweden)

    Rabus Hans

    2014-01-01

    Full Text Available Funded within the European Metrology Research Programme (EMRP [1], the joint research project “Biologically weighted quantities in radiotherapy” (BioQuaRT [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm, and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS. Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

  10. Research Support in Australian Academic Libraries: Services, Resources, and Relationships

    Science.gov (United States)

    Haddow, Gaby; Mamtora, Jayshree

    2017-01-01

    In the last decade Australian academic libraries have increasingly aligned their research support services with assessment criteria used in the national research evaluation exercise (Excellence for Research in Australia). The same period has seen growing interest in research impact outside of traditional measures, such as bibliometrics. Social…

  11. 7 CFR 2.67 - Administrator, Economic Research Service.

    Science.gov (United States)

    2010-01-01

    ... research on supply, demand, and trade in food and fiber products and the effects on the U.S. food and... Research, Education, and Economics § 2.67 Administrator, Economic Research Service. (a) Delegations... delegations of authority are made by the Under Secretary for Research, Education, and Economics to the...

  12. Growth Disparity between Medical Research and Medical Services ...

    Indian Academy of Sciences (India)

    First page Back Continue Last page Graphics. Growth Disparity between Medical Research and Medical Services in India. Research Institutions started in late 19th and early 20th century included Plague laboratory, Nutrition Research Lab at Coonoor; Malaria Research Institute in Delhi; King Institute, Guindy; Central ...

  13. 7 CFR 2.65 - Administrator, Agricultural Research Service.

    Science.gov (United States)

    2010-01-01

    ...) Provide national leadership and support for research programs and other research activities in the food... Science Award for research or advanced studies in the food and agricultural sciences (7 U.S.C. 3153). (21... goods or services in support of research, extension, or teaching activities in the food and agricultural...

  14. Key insights for the future of urban ecosystem services research

    Directory of Open Access Journals (Sweden)

    Peleg Kremer

    2016-06-01

    Full Text Available Understanding the dynamics of urban ecosystem services is a necessary requirement for adequate planning, management, and governance of urban green infrastructure. Through the three-year Urban Biodiversity and Ecosystem Services (URBES research project, we conducted case study and comparative research on urban biodiversity and ecosystem services across seven cities in Europe and the United States. Reviewing > 50 peer-reviewed publications from the project, we present and discuss seven key insights that reflect cumulative findings from the project as well as the state-of-the-art knowledge in urban ecosystem services research. The insights from our review indicate that cross-sectoral, multiscale, interdisciplinary research is beginning to provide a solid scientific foundation for applying the ecosystem services framework in urban areas and land management. Our review offers a foundation for seeking novel, nature-based solutions to emerging urban challenges such as wicked environmental change issues.

  15. DOE's foreign research reactor transportation services contract: Perspective and experience

    International Nuclear Information System (INIS)

    Patterson, John

    1997-01-01

    DOE committed to low- and moderate-income countries participating in the foreign research reactor spent fuel returns program that the United States government would provide for the transportation of the spent fuel. In fulfillment of that commitment, DOE entered into transportation services contracts with qualified, private-sector firms. NAC will discuss its experience as a transportation services provider, including range of services available to the foreign reactors, advantages to DOE and to the foreign research reactors, access to contract services by high income countries and potential advantages, and experience with initial tasks performed under the contract. (author)

  16. Research in thermal biology: Burning questions for coldwater stream fishes

    Science.gov (United States)

    McCullough, D.A.; Bartholow, J.M.; Jager, H.I.; Beschta, R.L.; Cheslak, E.F.; Deas, M.L.; Ebersole, J.L.; Foott, J.S.; Johnson, S.L.; Marine, K.R.; Mesa, M.G.; Petersen, J.H.; Souchon, Y.; Tiffan, K.F.; Wurtsbaugh, W.A.

    2009-01-01

    With the increasing appreciation of global warming impacts on ecological systems, in addition to the myriad of land management effects on water quality, the number of literature citations dealing with the effects of water temperature on freshwater fish has escalated in the past decade. Given the many biological scales at which water temperature effects have been studied, and the growing need to integrate knowledge from multiple disciplines of thermal biology to fully protect beneficial uses, we held that a survey of the most promising recent developments and an expression of some of the remaining unanswered questions with significant management implications would best be approached collectively by a diverse research community. We have identified five specific topic areas of renewed research where new techniques and critical thought could benefit coldwater stream fishes (particularly salmonids): molecular, organism, population/species, community and ecosystem, and policy issues in water quality. Our hope is that information gained through examination of recent research fronts linking knowledge at various scales will prove useful in managing water quality at a basin level to protect fish populations and whole ecosystems. Standards of the past were based largely on incipient lethal and optimum growth rate temperatures for fish species, while future standards should consider all integrated thermal impacts to the organism and ecosystem. ?? Taylor and Francis Group, LLC.

  17. Research progress in phytochemistry and biology of Aframomum species.

    Science.gov (United States)

    Amadi, Sarah Wambui; Zhang, Yan; Wu, Guanzhong

    2016-11-01

    The African genus Aframomum (Zingiberaceae) is a group of diverse tropical plants frequently collected yet largely neglected taxonomically. The current and unprecedented loss of species due to man-made habitat destruction and climate change adds a desperate urgency not only to understand the phylogenetics, chemotaxonomy and biology, but also to preserve the quickly disappearing species. The present systematic review reports on the research progress in phytochemistry, pharmacology and toxicology of Aframomum species. Scientific databases such as MedSci, PubMed, Scopus, Google Scholar and Web of Knowledge were used to retrieve publications (from the year 1990 to 2014) related to Aframomum plants, isolated compounds and their bioactivity, phytochemistry and toxicology. The keywords combinations for the search were: Aframomum; chemotaxonomy, phylogenetics, pharmacology and bioactive metabolites and toxicology. A total of 71 research articles that report on the biological activity of extracts and chemical constituents were recovered and presented in this review. Most published data related to the potential of Aframomum melegueta, a medicinal plant from West and Central Africa. The potential of phenols and terpenoids isolated from Aframomum plants were generally much better documented than that of arylalkanoids. Aframomum genus represents an enormous resource for novel compounds with a range of medicinal properties. However, these plants are under-researched and their conservation is poor. To unravel their full potential, efforts should be strengthened throughout the continent to establish the taxonomy, preserve the genus and explore novel medicinal properties.

  18. A theoretical framework to support research of health service innovation.

    Science.gov (United States)

    Fox, Amanda; Gardner, Glenn; Osborne, Sonya

    2015-02-01

    Health service managers and policy makers are increasingly concerned about the sustainability of innovations implemented in health care settings. The increasing demand on health services requires that innovations are both effective and sustainable; however, research in this field is limited, with multiple disciplines, approaches and paradigms influencing the field. These variations prevent a cohesive approach, and therefore the accumulation of research findings, in the development of a body of knowledge. The purpose of this paper is to provide a thorough examination of the research findings and provide an appropriate theoretical framework to examine sustainability of health service innovation. This paper presents an integrative review of the literature available in relation to sustainability of health service innovation and provides the development of a theoretical framework based on integration and synthesis of the literature. A theoretical framework serves to guide research, determine variables, influence data analysis and is central to the quest for ongoing knowledge development. This research outlines the sustainability of innovation framework; a theoretical framework suitable for examining the sustainability of health service innovation. If left unaddressed, health services research will continue in an ad hoc manner, preventing full utilisation of outcomes, recommendations and knowledge for effective provision of health services. The sustainability of innovation theoretical framework provides an operational basis upon which reliable future research can be conducted.

  19. How chemistry supports cell biology: the chemical toolbox at your service.

    Science.gov (United States)

    Wijdeven, Ruud H; Neefjes, Jacques; Ovaa, Huib

    2014-12-01

    Chemical biology is a young and rapidly developing scientific field. In this field, chemistry is inspired by biology to create various tools to monitor and modulate biochemical and cell biological processes. Chemical contributions such as small-molecule inhibitors and activity-based probes (ABPs) can provide new and unique insights into previously unexplored cellular processes. This review provides an overview of recent breakthroughs in chemical biology that are likely to have a significant impact on cell biology. We also discuss the application of several chemical tools in cell biology research. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Continuing training program in radiation protection in biological research centers

    International Nuclear Information System (INIS)

    Escudero, R.; Hidalgo, R.M.; Usera, F.; Macias, M.T.; Mirpuri, E.; Perez, J.; Sanchez, A.

    2008-01-01

    The use of ionizing radiation in biological research has many specific characteristics. A great variety of radioisotopic techniques involve unsealed radioactive sources, and their use not only carries a risk of irradiation, but also a significant risk of contamination. Moreover, a high proportion of researchers are in training and the labor mobility rate is therefore high. Furthermore, most newly incorporated personnel have little or no previous training in radiological protection, since most academic qualifications do not include training in this discipline. In a biological research center, in addition to personnel whose work is directly associated with the radioactive facility (scientific-technical personnel, operators, supervisors), there are also groups of support personnel The use of ionizing radiation in biological research has many specific characteristics. A great variety of radioisotopic techniques involve unsealed radioactive sources, and their use not only carries a risk of irradiation, but also a significant risk of contamination. Moreover, a high proportion of researchers are in training and the labor mobility rate is therefore high. Furthermore, most newly incorporated personnel have little or no previous training in radiological protection, since most academic qualifications do not include training in this discipline. In a biological research center, in addition to personnel whose work is directly associated with the radioactive facility (scientific-technical personnel, operators, supervisors), there are also groups of support personnel maintenance and instrumentation workers, cleaners, administrative personnel, etc. who are associated with the radioactive facility indirectly. These workers are affected by the work in the radioactive facility to varying degrees, and they therefore also require information and training in radiological protection tailored to their level of interaction with the installation. The aim of this study was to design a

  1. [Qualitative research in health services research - discussion paper, Part 1: What is the idea?].

    Science.gov (United States)

    Meyer, T; Karbach, U; Holmberg, C; Güthlin, C; Patzelt, C; Stamer, M

    2012-08-01

    In this first part of a 3-part discussion paper the working group "Qualitative Methods" in the German Network of Health Services Research (DNVF) identifies the potentials and opportunities qualitative research methods provide for health services research. Many research questions relevant for health services research require the use of qualitative methods. However, the potential of and need for qualitative research in health services research has not yet received sufficient attention from funding bodies. We discuss the applicability and importance of qualitative research for the field of health services research. We then move on to describe the key characteristics of qualitative research that need to be taken into account in health services research. We discuss characteristics such as open-ended (qualitative) data, interpretation of meanings, the search for contradictions, closeness to everyday life, openness towards change or modification of the research question and processes in the context of health services research. To ensure a high-quality approach in qualitative methods for the health services research, sufficient competency in methods and appropriate settings that account for the peculiarities of qualitative methods need to be developed. These include an appropriate time frame and sufficient and qualified personnel to conduct qualitative research. Qualitative research is not a research paradigm in itself rather it comprises of many different and diverging approaches. The goal of this paper is to show the diversity of qualitative research methods, its importance for health services research, and to open up the discussion on strategies for integrating qualitative methods into health services research. © Georg Thieme Verlag KG Stuttgart · New York.

  2. Service users' perceptions about their hospital admission elicited by service user-researchers or by clinicians.

    LENUS (Irish Health Repository)

    O'Donoghue, Brian

    2013-05-01

    OBJECTIVE Service users may express positive, ambivalent, or negative views of their hospital admission. The objective of this study was to determine whether the background of the interviewer-service user-researcher or clinician-influences the information elicited. The primary outcome was the level of perceived coercion on admission, and secondary outcomes were perceived pressures on admission, procedural justice, perceived necessity for admission, satisfaction with services, and willingness to consent to participate in the study. METHODS Participants voluntarily and involuntarily admitted to three hospitals in Ireland were randomly allocated to be interviewed at hospital discharge by either a service user-researcher or a clinician. Interviewers used the MacArthur Admission Experience Survey and the Client Satisfaction Questionnaire. RESULTS A total of 161 participants were interviewed. No differences by interviewer status or by admission status (involuntary or voluntary) were found in levels of perceived coercion, perceived pressures, procedural justice, perceived necessity, or satisfaction with services. Service users were more likely to decline to participate if their consent was sought by a service user-researcher (24% versus 8%, p=.003). CONCLUSIONS Most interviewees gave positive accounts of their admission regardless of interviewer status. The findings indicate that clinicians and researchers can be more confident that service users\\' positive accounts of admissions are not attributable to a response bias. Researchers can also feel more confident in directly comparing the results of studies undertaken by clinicians and by service user-researchers.

  3. "Biology Education"--An Emerging Interdisciplinary Area of Research

    Science.gov (United States)

    Rutledge, Michael

    2013-01-01

    The growing number of faculty positions in biology education, the formation of professional societies focused specifically on biology education, and the increasing number of publications in biology education over the past decade

  4. Explorations: A Research-Based Program Introducing Undergraduates to Diverse Biology Research Topics Taught by Grad Students and Postdocs

    Science.gov (United States)

    Brownell, Sara E.; Khalfan, Waheeda; Bergmann, Dominique; Simoni, Robert

    2013-01-01

    Undergraduate biology majors are often overwhelmed by and underinformed about the diversity and complexity of biological research that is conducted on research-intensive campuses. We present a program that introduces undergraduates to the diversity and scope of biological research and also provides unique teaching opportunities for graduate…

  5. BCTR: Biological and Chemical Technologies Research 1994 annual summary report

    Energy Technology Data Exchange (ETDEWEB)

    Petersen, G.

    1995-02-01

    The annual summary report presents the fiscal year (FY) 1994 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). Although the OIT was reorganized in 1991 and AICD no longer exists, this document reports on efforts conducted under the former structure. The annual summary report for 1994 (ASR 94) contains the following: program description (including BCTR program mission statement, historical background, relevance, goals and objectives); program structure and organization, selected technical and programmatic highlights for 1994; detailed descriptions of individual projects; a listing of program output, including a bibliography of published work; patents, and awards arising from work supported by BCTR.

  6. Research program on the biological effects of oil pollution

    International Nuclear Information System (INIS)

    Barrett, R.T.

    1991-12-01

    A national research program on the biological effects of oil pollution (FOBO) was initiated by the Norwegian Ministry of Environment in October 1983 in the light of the increasing oil exploration and production activity in the North Sea and northern Norwegian waters. Ambitions were high and five main fields of research were suggested: Seabirds, fish (incl. salmon), marine mammals, the littoral zone and plankton. However, due to the lack of interest on the part of other potential financers, e.g. the Ministry of Fisheries and the oil companies, to participate, the four-year programme had to be limited to the following three topics: Seabirds around bruding colonies and at sea; Higher plants along the shoreline; The littoral zone. The program ran from the autumn of 1985 to the end of 1989 and this report summarizes the main results and conclusions of each project. 95 refs., 52 figs., 9 tabs

  7. 2010 Tetrapyrroles, Chemistry & Biology of Gordon Research Conference

    Energy Technology Data Exchange (ETDEWEB)

    Angela Wilks

    2010-07-30

    The objective of the Chemistry & Biology of Tetrapyrroles Gordon Conference is to bring together researchers from diverse disciplines that otherwise would not interact. By bringing biologists, chemists, engineers and clinicians with a common interest in tetrapyrroles the conference provides a forum for cross-disciplinary ideas and collaboration. The perspective provided by biologists, chemists, and clinicians working in fields such as newly discovered defects in human porphyrin metabolism, the myriad of strategies for light harvesting in photosynthetic organisms, novel tetrapyrroles that serve as auxiliary chromophores or enzyme cofactors, synthetic strategies in the design of novel tetrapyrrole scaffolds, and tetrapyrrole based cell signaling and regulatory systems, makes this conference unique in the field. Over the years the growing evidence for the role of tetrapyrroles and their reactive intermediates in cell signaling and regulation has been of increasing importance at this conference. The 2010 conference on Chemistry & Biology of Tetrapyrroles will focus on many of these new frontiers as outlined in the preliminary program listed. Speakers will emphasize unpublished results and new findings in the field. The oral sessions will be followed by the highly interactive afternoon poster sessions. The poster sessions provide all conferees with the opportunity to present their latest research and to exchange ideas in a more informal setting. As in the past, this opportunity will continue during the nightly social gathering that takes place in the poster hall following the evening lectures. All conferees are encouraged to submit and present posters. At the conference the best poster in the areas of biology, chemistry and medicine will be selected by a panel of previous conference chairs.

  8. Globus: Service and Platform for Research Data Lifecycle Management

    Science.gov (United States)

    Ananthakrishnan, R.; Foster, I.

    2017-12-01

    Globus offers a range of data management capabilities to the community as hosted services, encompassing data transfer and sharing, user identity and authorization, and data publication. Globus capabilities are accessible via both a web browser and REST APIs. Web access allows researchers to use Globus capabilities through a software-as-a-service model; and the REST APIs address the needs of developers of research services, who can now use Globus as a platform, outsourcing complex user and data management tasks to Globus services. In this presentation, we review Globus capabilities and outline how it is being applied as a platform for scientific services, and highlight work done to link computational analysis flows to the underlying data through an interactive Jupyter notebook environment to promote immediate data usability, reusability of these flows by other researchers, and future analysis extensibility.

  9. Methods of 15N tracer research in biological systems

    International Nuclear Information System (INIS)

    Hirschberg, K.; Faust, H.

    1985-01-01

    The application of the stable isotope 15 N is of increasing importance in different scientific disciplines, especially in medicine, agriculture, and the biosciences. The close correlation between the growing interest and improvements of analytical procedures resulted in remarkable advances in the 15 N tracer technique. On the basis of the latest results of 15 N tracer research in life sciences and agriculture methods of 15 N tracer research in biological systems are compiled. The 15 N methodology is considered under three headings: Chemical analysis with a description of methods of sample preparation (including different separation and isolation methods for N-containing substances of biological and agricultural origin) and special procedures converting ammonia to molecular nitrogen. Isotopic analysis with a review on the most important methods of isotopic analysis of nitrogen: mass spectrometry (including the GC-MS technique), emission spectrometry, NMR spectroscopy, and other analytical procedures. 15 N-tracer techniques with a consideration of the role of the isotope dilution analysis as well as different labelling techniques and the mathematical interpretation of tracer data (modelling, N turnover experiments). In these chapters also sources of errors in chemical and isotopic analysis, the accuracy of the different methods and its importance on tracer experiments are discussed. Procedures for micro scale 15 N analysis and aspects of 15 N analysis on the level of natural abundance are considered. Furthermore some remarks on isotope effects in 15 N tracer experiments are made. (author)

  10. Application of the selected physical methods in biological research

    Directory of Open Access Journals (Sweden)

    Jaromír Tlačbaba

    2013-01-01

    Full Text Available This paper deals with the application of acoustic emission (AE, which is a part of the non-destructive methods, currently having an extensive application. This method is used for measuring the internal defects of materials. AE has a high potential in further research and development to extend the application of this method even in the field of process engineering. For that matter, it is the most elaborate acoustic emission monitoring in laboratory conditions with regard to external stimuli. The aim of the project is to apply the acoustic emission recording the activity of bees in different seasons. The mission is to apply a new perspective on the behavior of colonies by means of acoustic emission, which collects a sound propagation in the material. Vibration is one of the integral part of communication in the community. Sensing colonies with the support of this method is used for understanding of colonies biological behavior to stimuli clutches, colony development etc. Simulating conditions supported by acoustic emission monitoring system the illustrate colonies activity. Collected information will be used to represent a comprehensive view of the life cycle and behavior of honey bees (Apis mellifera. Use of information about the activities of bees gives a comprehensive perspective on using of acoustic emission in the field of biological research.

  11. Research into Flexibility Services. Final Report

    International Nuclear Information System (INIS)

    2005-03-01

    The Dutch Office for Energy Regulation (DTe) is currently investigating the Dutch gas flexibility market. DTe is concerned that Gasunie is dominant in the market. In order to take a view of Gasunie's market position, DTe needs to first define the market for gas flexibility services and then explore whether Gasunie is dominant in the market (or markets). DTe has commissioned Frontier to undertake the respective formal analysis. This report summarises the findings by Frontier. On the basis of this report and a formal consultation process, We follow a three-step approach to the study: (1) We first define the relevant markets for gas flexibility (Section 3); (2) We then analyse the structure of the markets for flexibility that we have defined (Section 4); (3) Finally, we assess whether Gasunie is dominant in the relevant markets, taking account of market shares and other competitive effects (Section 5). This document is the Final Report, which contains our views as to the market definition for gas flexibility and the position of Gasunie in the market. The remainder of this document is set out as follows: Section 2 provides an overview of aspects of the Dutch gas industry relevant to this study; Section 3 sets out our approach to defining the market and de-Mops our conclusions on the markets for gas flexibility; Section 4 provides our view as to the structure of the relevant flexibility markets as defined in Section 3; Section 5 reports our assessment as to whether Gasunie is dominant in the relevant markets, taking account of market shares and other competitive effects; Section 6 sets out our conclusions about the competitive assessment. We include three annexes that set out details related to the market definition and analysis of dominance

  12. Key insights for the future of urban ecosystem services research

    NARCIS (Netherlands)

    Kremer, P. (Peleg); Hamstead, Z. (Zoé); D. Haase (Dagmar); T. McPhearson (Timon); N. Frantzeskaki (Niki); E. Andersson (Erik); N. Kabisch (Nadja); N. Larondelle (Neele); E. Rall (Emily); Voigt, A. (Annette); F. Baró (Francesc); Bertram, C. (Christine); E. Gómez-Baggethun (E.); R. Hansen (Rieke); A. Kaczorowska (Anna); J.-H. Kain (Jaan-Henrik); Kronenberg, J. (Jakub); Langemeyer, J. (Johannes); S. Pauleit (Stephan); Rehdanz, K. (Katrin); M. Schewenius (Maria); Van Ham, C. (Chantal); Wurster, D. (Daniel); T. Elmqvist (Thomas)

    2016-01-01

    textabstractUnderstanding the dynamics of urban ecosystem services is a necessary requirement for adequate planning, management, and governance of urban green infrastructure. Through the three-year Urban Biodiversity and Ecosystem Services (URBES) research project, we conducted case study and

  13. Pediatric Oncology Branch - Support Services | Center for Cancer Research

    Science.gov (United States)

    Support Services As part of the comprehensive care provided at the NCI Pediatric Oncology Branch, we provide a wide range of services to address the social, psychological, emotional, and practical facets of pediatric cancer and to support patients and families while they are enrolled in clinical research protocols.

  14. Professor's e-stallion service auction benefits equine reproductive research

    OpenAIRE

    Douglas, Jeffrey S.

    2005-01-01

    Move over EBAY... an equine veterinarian in the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech has created an internet-based stallion service auction to benefit equine reproductive research in the college.

  15. Research Data Management - Building Service Infrastructure and Capacity

    KAUST Repository

    Baessa, Mohamed A.

    2018-03-07

    Research libraries support the missions of their institutions by facilitating the flow of scholarly information to and from the institutions’ researchers. As research in many disciplines becomes more data and software intensive, libraries are finding that services and infrastructure developed to preserve and provide access to textual documents are insufficient to meet their institutions’ needs. In response, libraries around the world have begun assessing the data management needs of their researchers, and expanding their capacity to meet the needs that they find. This discussion panel will discuss approaches to building research data management services and infrastructure in academic libraries. Panelists will discuss international efforts to support research data management, while highlighting the different models that universities have adopted to provide a mix of services and infrastructure tailored to their local needs.

  16. Communication and Community in Digital Entertainment Services. Prestudy Research Report

    OpenAIRE

    Järvinen, Aki; Heliö, Satu; Mäyrä, Frans

    2002-01-01

    CC-DES is a future-orientated research and development project where new forms of communication and interaction in digital entertainment services are analysed. The project carries out user-focused research into communication forms and design solutions encouraging communality and gameplay in digital entertainment products and services. The prestudy focuses on analysing existing commercial media products and defining crucial concepts, such as gameplay and playability. A theoretical model for...

  17. Division of Biological and Medical Research annual report, 1980

    International Nuclear Information System (INIS)

    Rosenthal, M.W.

    1981-08-01

    The research during 1980 in the Division of Biological and Medical Research, Argonne National Laboratory, is summarized. Research related to nuclear energy includes the delineation, in the beagle, of the responses to continuous low level 60 Co gamma radiation and the development of cellular indicators of preclinical phases of leukemia; comparison of lifetime effects in mice of low level neutron and 60 Co gamma radiation; studies of the genetic effects of high LET radiations; and studies of the gastrointestinal absorption of the actinide elements. Research related to nonuclear energy sources deals with characterization and toxicological evaluation of process streams and effluents of coal gasification; with electrical storage systems; and electric fields associated with energy transmission. Proteins in human urine and selected tissues are examined by two-dimensional electrophoresis to detect disease and pollutant related changes. Assessment of human risk associated with nuclearing collective dose commitment will result in more attention being paid to potential releases of radionuclides at relatively short times after disposal

  18. A Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm

    Energy Technology Data Exchange (ETDEWEB)

    Aderem, Alan; Adkins, Joshua N.; Ansong, Charles; Galagan, James; Kaiser, Shari; Korth, Marcus J.; Law, G. L.; McDermott, Jason E.; Proll, Sean; Rosenberger, Carrie; Schoolnik, Gary; Katze, Michael G.

    2011-02-01

    The 20th century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and water borne illnesses are frequent, multi-drug resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past—including the intense focus on individual genes and proteins typical of molecular biology—have not been sufficient to address these challenges. The first decade of the 21st century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program we think that the time is at hand to redefine the pathogen-host research paradigm.

  19. Advances, gaps, and future prospects in biological soil crust research

    Science.gov (United States)

    Weber, Bettina; Büdel, Burkhard; Belnap, Jayne

    2017-04-01

    Research progress has led to the understanding that biological soil crusts (biocrusts) are often complete miniature ecosystems comprising a variety of photosynthesizers (cyanobacteria, algae, lichens, bryophytes), decomposers like bacteria, fungi, and archaea, and heterotrophic organisms, like protozoa, nematodes, and microarthropods feeding on them. Biocrusts are one of the oldest terrestrial ecosystems, playing central roles in the structure and functioning of dryland ecosystems and presumably also influencing global biogeochemical cycles. On the other hand, biocrusts have been shown to be highly sensitive to global change, being easily destroyed by mechanical disturbance and severely threatened by minor changes in climate patterns. Despite the large increase in biocrust research, we still see major knowledge gaps which need to be tackled. Considering biodiversity studies, there are major regions of potential biocrust occurrence, where hardly any studies have been conducted. Molecular identification techniques are increasingly employed, but genetically characterized entities need to be linked with morphologically identified organisms to identify their ecological roles. Although there is a large body of research on the role of biocrusts in water and nutrient budgets, we are still far from closing the overall cycles. Results suggest that not all mechanisms have been identified, yet, leading to sometimes contradictory results between different studies. Knowledge on how to minimize impact to biocrusts during surface-disturbing activities has hardly been gained, and despite research efforts, instructions on effective biocrust restoration are still exemplary. In order to fill these research gaps, novel scientific approaches are needed. We expect that global research networks could be extremely helpful to answer scientific questions by tackling them within different regions, utilizing the same methodological techniques. Global networks could also be used for long

  20. An action research approach to practice, service and legislative change.

    Science.gov (United States)

    Sullivan, Elise; Hegney, Desley G; Francis, Karen

    2013-11-01

    To describe the action research approach taken to engage a multidisciplinary group of health professionals and managers from five rural health services with government officers in redesigning their emergency care services and informing legislative change. The diminishing size of the medical workforce across rural Victoria in Australia captured the Victorian state government's attention when this threatened the sustainability of emergency care services in rural and remote hospitals in 2006. The government funded the collaborative practice model pilot between 2006 and 2008 to develop and test an alternative model of emergency care service in which nurses practised at a more advanced and autonomous level. Data were sourced from a combination of interviews, focus groups and patient records. Qualitative data were analysed using convergent interview and thematic analysis. Quantitative data were analysed using frequencies and cross tabulations. The three critical success factors owing to action research are presented. It provided a politically safe approach to service, policy and legislative change, ensured collaboration permeated the endeavour and helped to shift the focus from a technical to an emancipatory approach to action research. Action research was key to the success achieved by the participants in changing clinical practice, service delivery and the Victorian Drugs Poisons and Controlled Substances Act (1981) to authorise registered nurses to supply medicines. This paper offers an approach that nurses in practice, management and government can take to drive changes at practice, service and legislative levels in advanced nursing practice.

  1. Life lines: An art history of biological research around 1800.

    Science.gov (United States)

    Bruhn, Matthias

    2011-12-01

    Around 1800, the scientific "illustrator" emerged as a new artistic profession in Europe. Artists were increasingly sought after in order to picture anatomical dissections and microscopic observations and to translate drawings into artworks for books and journals. By training and technical expertise, they introduced a particular kind of knowledge into scientific perception that also shaped the common image of nature. Illustrations of scientific publications, often undervalued as a biased interpretation of facts and subordinate to logic and description, thus convey an 'art history' of science in its own right, relevant both for the understanding of biological thought around 1800 as well as for the development of the arts and their historiography. The article is based on an analysis of botanical treatises produced for the Göttingen Society of Sciences in 1803, during an early phase of microscopic cell research, in order to determine the constitutive role of artistic knowledge and the media employed for the visualization and conceptualization of biological issues. Copyright © 2011 Elsevier Ltd. All rights reserved.

  2. Growth Analysis of Cancer Biology Research, 2000-2011

    Directory of Open Access Journals (Sweden)

    Keshava,

    2015-09-01

    Full Text Available Methods and Material: The PubMed database was used for retrieving data on 'cancer biology.' Articles were downloaded from the years 2000 to 2011. The articles were classified chronologically and transferred to a spreadsheet application for analysis of the data as per the objectives of the study. Statistical Method: To investigate the nature of growth of articles via exponential, linear, and logistics tests. Result: The year wise analysis of the growth of articles output shows that for the years 2000 to 2005 and later there is a sudden increase in output, during the years 2006 to 2007 and 2008 to 2011. The high productivity of articles during these years may be due to their significance in cancer biology literature, having received prominence in research. Conclusion: There is an obvious need for better compilations of statistics on numbers of publications in the years from 2000 to 2011 on various disciplines on a worldwide scale, for informed critical assessments of the amount of new knowledge contributed by these publications, and for enhancements and refinements of present Scientometric techniques (citation and publication counts, so that valid measures of knowledge growth may be obtained. Only then will Scientometrics be able to provide accurate, useful descriptions and predictions of knowledge growth.

  3. Using biological samples in epidemiological research on drugs of abuse

    Directory of Open Access Journals (Sweden)

    Hallvard Gjerde

    2011-12-01

    Full Text Available Blood, oral fluid (saliva, urine and hair are the most commonly used biological matrices for drug testing in epidemiological drug research. Other biological matrices may also be used for selected purposes. Blood reflects recent drug intake and may be used to assess impairment. Oral fluid reflects drug presence in blood and thereby also recent intake, but drug concentrations in this matrix cannot be used to accurately estimate concentrations in blood. Urine reflects drug use during the last few days and in some cases for a longer period, but does not indicate the dose size or frequency of use. Hair reflects drug use during several months, but is a poor matrix for detecting use of cannabis. If using a single drug dose, this can be detected in blood and urine if the sample is taken within the detection timeframes, in most cases also in oral fluid. Single drug use is most often insufficient for producing a positive test result in a sample of hair. For cocaine and amphetamine, weekly use may be needed, while for cannabis a positive result is not guaranteed even after daily use. Refusal rates are lowest for oral fluid and highest for blood and hair samples. The analytical costs are lowest for urine and highest for hair. Combined use of questionnaires/interviews and drug testing detects more drug use than when using only one of those methods and is therefore expected to give more accurate data.

  4. Phytochemical and biological research of Fritillaria medicine resources.

    Science.gov (United States)

    Hao, Da-Cheng; Gu, Xiao-Jie; Xiao, Pei-Gen; Peng, Yong

    2013-07-01

    The genus Fritillaria is a botanical source for various pharmaceutically active components, which have been commonly used in traditional Chinese medicine for thousands of years. Increasing interest in Fritillaria medicinal resources has led to additional discoveries of steroidal alkaloids, saponins, terpenoids, glycosides and many other compounds in various Fritillaria species, and to investigations on their chemotaxonomy, molecular phylogeny and pharmacology. In continuation of studies on Fritillaria pharmacophylogeny, the phytochemistry, chemotaxonomy, molecular biology and phylogeny of Fritillaria and their relevance to drug efficacy is reviewed. Literature searching is used to characterize the global scientific effort in the flexible technologies being applied. The interrelationship within Chinese Bei Mu species and between Chinese species, and species distributed outside of China, is clarified by the molecular phylogenetic inferences based on nuclear and chloroplast DNA sequences. The incongruence between chemotaxonomy and molecular phylogeny is revealed and discussed. It is essential to study more species for both the sustainable utilization of Fritillaria medicinal resources and for finding novel compounds with potential clinical utility. Systems biology and omics technologies will play an increasingly important role in future pharmaceutical research involving the bioactive compounds of Fritillaria. Copyright © 2013 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  5. Stream Water Quality and Service Learning in an Introductory Biology Class

    Directory of Open Access Journals (Sweden)

    Wendy L. Gorman

    2010-04-01

    Full Text Available Northland College is a small environmental liberal arts college in northern Wisconsin near Lake Superior. In the fall of 2007 and 2008 students in a mixed science majors/non-majors introductory biology course engaged in a semester-long, service-learning project to monitor E. coli in city stormwater draining into Bay City Creek, a small stream that flows through campus and the town of Ashland before flowing into Lake Superior. Such monitoring is beyond the budget of most municipalities, but is an important public health and aesthetic issue for Ashland and Lake Superior. Our hypothesis was that this service-learning research project would have a positive impact on student learning and student perception of science, and the project would generate useful information for city leaders. Students collected and processed water samples using a standard protocol, analyzed the effect of stormwater on stream water quality, and presented their data in the form of posters to the mayor, a city administrator, and the Provost. Student learning was assessed by a poster-grading rubric, and by online and Northland College instruments. Student perceptions of science were found to be more positive than in the year preceding this project, even when clear answers were not found from their scientific investigation, and there appeared to be no distinction in responses between science majors and non-majors.

  6. STRUCTURAL BIOLOGY AND MOLECULAR MEDICINE RESEARCH PROGRAM (LSBMM)

    International Nuclear Information System (INIS)

    Eisenberg, David S.

    2008-01-01

    The UCLA-DOE Institute of Genomics and Proteomics is an organized research unit of the University of California, sponsored by the Department of Energy through the mechanism of a Cooperative Agreement. Today the Institute consists of 10 Principal Investigators and 7 Associate Members, developing and applying technologies to promote the biological and environmental missions of the Department of Energy, and 5 Core Technology Centers to sustain this work. The focus is on understanding genomes, pathways and molecular machines in organisms of interest to DOE, with special emphasis on developing enabling technologies. Since it was founded in 1947, the UCLA-DOE Institute has adapted its mission to the research needs of DOE and its progenitor agencies as these research needs have changed. The Institute started as the AEC Laboratory of Nuclear Medicine, directed by Stafford Warren, who later became the founding Dean of the UCLA School of Medicine. In this sense, the entire UCLA medical center grew out of the precursor of our Institute. In 1963, the mission of the Institute was expanded into environmental studies by Director Ray Lunt. I became the third director in 1993, and in close consultation with David Galas and John Wooley of DOE, shifted the mission of the Institute towards genomics and proteomics. Since 1993, the Principal Investigators and Core Technology Centers are entirely new, and the Institute has separated from its former division concerned with PET imaging. The UCLA-DOE Institute shares the space of Boyer Hall with the Molecular Biology Institute, and assumes responsibility for the operation of the main core facilities. Fig. 1 gives the organizational chart of the Institute. Some of the benefits to the public of research carried out at the UCLA-DOE Institute include the following: The development of publicly accessible, web-based databases, including the Database of Protein Interactions, and the ProLinks database of genomicly inferred protein function linkages

  7. Microgravity research in plant biological systems: Realizing the potential of molecular biology

    Science.gov (United States)

    Lewis, Norman G.; Ryan, Clarence A.

    1993-01-01

    The sole all-pervasive feature of the environment that has helped shape, through evolution, all life on Earth is gravity. The near weightlessness of the Space Station Freedom space environment allows gravitational effects to be essentially uncoupled, thus providing an unprecedented opportunity to manipulate, systematically dissect, study, and exploit the role of gravity in the growth and development of all life forms. New and exciting opportunities are now available to utilize molecular biological and biochemical approaches to study the effects of microgravity on living organisms. By careful experimentation, we can determine how gravity perception occurs, how the resulting signals are produced and transduced, and how or if tissue-specific differences in gene expression occur. Microgravity research can provide unique new approaches to further our basic understanding of development and metabolic processes of cells and organisms, and to further the application of this new knowledge for the betterment of humankind.

  8. Forest Service Global Change Research Strategy, 2009-2019

    Science.gov (United States)

    Allen Solomon; Richard Birdsey; Linda A. Joyce; Jennifer Hayes

    2009-01-01

    In keeping with the research goals of the U.S. Climate Change Science Program, the Research and Development agenda of the Forest Service, U.S. Department of Agriculture (USDA), helps define climate change policy and develop best management practices for forests (both rural and urban) and grasslands. These actions are taken to sustain ecosystem health, adjust management...

  9. Growth Disparity between Medical Research and Medical Services ...

    Indian Academy of Sciences (India)

    Growth Disparity between Medical Research and Medical Services in India. British rulers opened hospitals for modern medicine; medical colleges; nurses schools etc. in the 19th century to the joyous welcome of natives. During the same period, they set up Indian Research Fund Association two years ahead of the MRC of ...

  10. Cell Science and Cell Biology Research at MSFC: Summary

    Science.gov (United States)

    2003-01-01

    The common theme of these research programs is that they investigate regulation of gene expression in cells, and ultimately gene expression is controlled by the macromolecular interactions between regulatory proteins and DNA. The NASA Critical Path Roadmap identifies Muscle Alterations and Atrophy and Radiation Effects as Very Serious Risks and Severe Risks, respectively, in long term space flights. The specific problem addressed by Dr. Young's research ("Skeletal Muscle Atrophy and Muscle Cell Signaling") is that skeletal muscle loss in space cannot be prevented by vigorous exercise. Aerobic skeletal muscles (i.e., red muscles) undergo the most extensive atrophy during long-term space flight. Of the many different potential avenues for preventing muscle atrophy, Dr. Young has chosen to study the beta-adrenergic receptor (betaAR) pathway. The reason for this choice is that a family of compounds called betaAR agonists will preferentially cause an increase in muscle mass of aerobic muscles (i.e., red muscle) in animals, potentially providing a specific pharmacological solution to muscle loss in microgravity. In addition, muscle atrophy is a widespread medical problem in neuromuscular diseases, spinal cord injury, lack of exercise, aging, and any disease requiring prolonged bedridden status. Skeletal muscle cells in cell culture are utilized as a model system to study this problem. Dr. Richmond's research ("Radiation & Cancer Biology of Mammary Cells in Culture") is directed toward developing a laboratory model for use in risk assessment of cancer caused by space radiation. This research is unique because a human model will be developed utilizing human mammary cells that are highly susceptible to tumor development. This approach is preferential over using animal cells because of problems in comparing radiation-induced cancers between humans and animals.

  11. Evolutionary Developmental Biology (Evo-Devo) Research in Latin America.

    Science.gov (United States)

    Marcellini, Sylvain; González, Favio; Sarrazin, Andres F; Pabón-Mora, Natalia; Benítez, Mariana; Piñeyro-Nelson, Alma; Rezende, Gustavo L; Maldonado, Ernesto; Schneider, Patricia Neiva; Grizante, Mariana B; Da Fonseca, Rodrigo Nunes; Vergara-Silva, Francisco; Suaza-Gaviria, Vanessa; Zumajo-Cardona, Cecilia; Zattara, Eduardo E; Casasa, Sofia; Suárez-Baron, Harold; Brown, Federico D

    2017-01-01

    Famous for its blind cavefish and Darwin's finches, Latin America is home to some of the richest biodiversity hotspots of our planet. The Latin American fauna and flora inspired and captivated naturalists from the nineteenth and twentieth centuries, including such notable pioneers such as Fritz Müller, Florentino Ameghino, and Léon Croizat who made a significant contribution to the study of embryology and evolutionary thinking. But, what are the historical and present contributions of the Latin American scientific community to Evo-Devo? Here, we provide the first comprehensive overview of the Evo-Devo laboratories based in Latin America and describe current lines of research based on endemic species, focusing on body plans and patterning, systematics, physiology, computational modeling approaches, ecology, and domestication. Literature searches reveal that Evo-Devo in Latin America is still in its early days; while showing encouraging indicators of productivity, it has not stabilized yet, because it relies on few and sparsely distributed laboratories. Coping with the rapid changes in national scientific policies and contributing to solve social and health issues specific to each region are among the main challenges faced by Latin American researchers. The 2015 inaugural meeting of the Pan-American Society for Evolutionary Developmental Biology played a pivotal role in bringing together Latin American researchers eager to initiate and consolidate regional and worldwide collaborative networks. Such networks will undoubtedly advance research on the extremely high genetic and phenotypic biodiversity of Latin America, bound to be an almost infinite source of amazement and fascinating findings for the Evo-Devo community. © 2016 Wiley Periodicals, Inc.

  12. Forging New Service Paths: Institutional Approaches to Providing Research Data Management Services

    Directory of Open Access Journals (Sweden)

    Regina Raboin

    2012-01-01

    Full Text Available Objective: This paper describes three different institutional experiences in developing research data management programs and services, challenges/opportunities and lessons learned.Overview: This paper is based on the Librarian Panel Discussion during the 4th Annual University of Massachusetts and New England Region e-Science Symposium. Librarians representing large public and private research universities presented an overview of service models developed at their respective organizations to bring support for data management and eScience to their communities. The approaches described include two library-based, integrated service models and one collaboratively-staffed, center-based service model.Results: Three institutions describe their experiences in creating the organizational capacity for research data management support services. Although each institutional approach is unique, common challenges include garnering administrative support, managing the integration of services with new or existing staff structures, and continuing to meet researchers needs as they evolve.Conclusions: There is no one way to provide research data management services, but any staff position, committee, or formalized center reflects an overarching organizational commitment to data management support.

  13. Establishing a shared research data service for UK universities

    Directory of Open Access Journals (Sweden)

    John Kaye

    2017-03-01

    Full Text Available Research data is central to research; sharing and enabling access to research data are now seen as essential to research integrity. Making research data accessible goes beyond validation as it also supports new research and innovation. However, sharing of research data is not yet ‘business as usual’, though digital technology is making data sharing much easier and Jisc is currently harnessing this in partnership with the UK research community to develop the research data shared service (RDSS. The RDSS will enable research organizations to support researchers to easily deposit data for publication, discovery, safe storage, long-term archiving and preservation. Ultimately it will support researchers in sharing and re-using data and will enable increased reproducibility of research. The initial impetus for the development is to better enable institutions to meet policy requirements around research data, whilst exploiting efficiencies and best practice generated by working collectively. This article examines the development of this service so far, from initial ideas and requirements gathering to entering technical development.

  14. The Implementation of Research-based Learning on Biology Seminar Course in Biology Education Study Program of FKIP UMRAH

    Science.gov (United States)

    Amelia, T.

    2018-04-01

    Biology Seminar is a course in Biology Education Study Program of Faculty of Teacher Training and Education University of Maritim Raja Ali Haji (FKIP UMRAH) that requires students to have the ability to apply scientific attitudes, perform scientific writing and undertake scientific publications on a small scale. One of the learning strategies that can drive the achievement of learning outcomes in this course is Research-Based Learning. Research-Based Learning principles are considered in accordance with learning outcomes in Biology Seminar courses and generally in accordance with the purpose of higher education. On this basis, this article which is derived from a qualitative research aims at describing Research-based Learning on Biology Seminar course. Based on a case study research, it was known that Research-Based Learning on Biology Seminar courses is applied through: designing learning activities around contemporary research issues; teaching research methods, techniques and skills explicitly within program; drawing on personal research in designing and teaching courses; building small-scale research activities into undergraduate assignment; and infusing teaching with the values of researchers.

  15. RESEARCH OF EXPECTED AND PERCEIVED SERVICE QUALITY IN HOTEL MANAGEMENT

    Directory of Open Access Journals (Sweden)

    Milan Bradić

    2011-06-01

    Full Text Available The paper examines the concept and measurement of quality of service in the hotel sector. The ratings of guests’ expectations and calculations of SERVQUAL gap (discrepancies between expectations and perceptions, has been the most reliable method in estimating the precise diagnosis of quality deficiency. The findings of questionnaire research aimed at measuring the service quality in spa hotels are presented in this paper. The research was conducted in hotels of the third category (three-star hotels which are located in the most visited spa centers in Serbia: Vrnjačka banja, Niška banja, Soko banja and Mataruška banja, during the months of September - November 2009. Service quality was measured with a model based on SERVQUAL model. The results may be important for providers of hotel services and contribute to the advancement of business through the adjustment of the product needs of hotel guests.

  16. Supporting research readiness in social enterprise health services.

    Science.gov (United States)

    Wright, Nat M J; Hearty, Philippa; Harris, Linda; Burnell, Andrew; Pender, Sue; Oxnard, Chris; Charlesworth, George

    2017-09-13

    Health-based social enterprises are spun out of the NHS, yet continue to provide NHS-funded services. With the spin-out, however, formal processes for research governance were lost. Patients have a right to take part in research, regardless of where they access healthcare. This paper discusses the barriers to social enterprises undertaking applied health research and makes recommendations to address the need for equivalence of governance processes with NHS trusts.

  17. Supporting research readiness in social enterprise health services

    OpenAIRE

    Wright, Nat M. J.; Hearty, Philippa; Harris, Linda; Burnell, Andrew; Pender, Sue; Oxnard, Chris; Charlesworth, George

    2017-01-01

    Health-based social enterprises are spun out of the NHS, yet continue to provide NHS-funded services. With the spin-out, however, formal processes for research governance were lost. Patients have a right to take part in research, regardless of where they access healthcare. This paper discusses the barriers to social enterprises undertaking applied health research and makes recommendations to address the need for equivalence of governance processes with NHS trusts.

  18. Roles of radiation chemistry in development and research of radiation biology

    International Nuclear Information System (INIS)

    Min Rui

    2009-01-01

    Radiation chemistry acts as a bridge connecting radiation physics with radiation biology in spatial and temporal insight. The theory, model, and methodology coming from radiation chemistry play an important role in the research and development of radiation biology. The chemical changes induced by ionizing radiation are involved not only in early event of biological effects caused by ionizing radiation but in function radiation biology, such as DNA damage and repair, sensitive modification, metabolism and function of active oxygen and so on. Following the research development of radiation biology, systems radiation biology, accurate quality and quantity of radiation biology effects need more methods and perfect tools from radiation chemistry. (authors)

  19. Using biological control research in the classroom to promote scientific inquiry and literacy

    Science.gov (United States)

    Many scientists who research biological control also teach at universities or more informally through cooperative outreach. The purpose of this paper is to review biological control activities for the classroom in four refereed journals, The American Biology Teacher, Journal of Biological Education...

  20. Current state of seagrass ecosystem services: Research and policy integration

    KAUST Repository

    Ruiz-Frau, A.

    2017-10-12

    Seagrasses contribute to the maintenance of human wellbeing. However certain aspects of their role as ecosystem service (ES) providers remain understudied. Here, we synthesise the state of seagrass ES (SGES) research and policy implications. Additionally, we recommend ways in which SGES research can be integrated in to policy design, by drawing lessons from the case of Blue Carbon (BC). SGES research suffers from three main biases: a geographical bias, SGES has been restricted to chartered seagrass areas; a type of service research bias, provisioning and regulating services have received extensive attention while cultural services remain understudied; a type of discipline bias, the ecological aspects of SGES have been well documented while economic and social aspects remain in comparison understudied. These are particularly important, as an understanding of the social and economic considerations of the provision of ES is fundamental to facilitate its integration into policy frameworks. Lessons drawn from the operationalization process of BC show the reoccurrence of certain aspects that have enabled the integration of BC into policy. These aspects are grouped under 4 different categories. From the analysis of these elements we draw lessons that could facilitate the operationalization of other ecosystem services and their incorporation into management policy frameworks.

  1. Joint Service Chemical and Biological Defense Program FY 08-09 Overview

    Science.gov (United States)

    2007-10-01

    Biological Defense (MEDBIO) CONTRACTORS dynPort vaccine company FREDERICK, MD emergent Biosolutions LANSING, MI cangene corporation WINNIPEG, MANITOBA...army medical research institute of infectious diseases Consolidated Program Locator Map MASSACHUSETTS nctrf wolf coach MICHIGAN emergent Biosolutions

  2. Investigation of the Nature of Metaconceptual Processes of Pre-Service Biology Teachers

    Science.gov (United States)

    Yuruk, Nejla; Selvi, Meryem; Yakisan, Mehmet

    2017-01-01

    Purpose of Study: The aim of this study is to investigate the nature of pre-service biology teachers' metaconceptual processes that were active as they participated in metaconceptual teaching activities. Methods: Several instructional activities, including poster drawing, concept mapping, group and class discussions, and journal writing, were…

  3. Implementing an online pharmaceutical service using design science research.

    Science.gov (United States)

    Lapão, Luís Velez; da Silva, Miguel Mira; Gregório, João

    2017-03-27

    The rising prevalence of chronic diseases is pressing health systems to introduce reforms. Primary healthcare and multidisciplinary models have been suggested as approaches to deal with this challenge, with new roles for nurses and pharmacists being advocated. More recently, implementing healthcare based on information systems and technologies (e.g. eHealth) has been proposed as a way to improve health services. However, implementing online pharmaceutical services, including their adoption by pharmacists and patients, is still an open research question. In this paper we present ePharmacare, a new online pharmaceutical service implemented using Design Science Research. The Design Science Research Methodology (DSRM) was chosen to implement this online service for chronic diseases management. In the paper, DSRM's different activities are explained, from the definition of the problem to the evaluation of the artifact. During the design and development activities, surveys, observations, focus groups, and eye-tracking glasses were used to validate pharmacists' and patients' requirements. During the demonstration and evaluation activities the new service was used with real-world pharmacists and patients. The results show the contribution of DSRM in the implementation of online services for pharmacies. We found that pharmacists spend only 50% of their time interacting with patients, uncovering a clear opportunity to implement online pharmaceutical care services. On the other hand, patients that regularly visit the same pharmacy recognize the value in patient follow-up demanding to use channels such as the Internet for their pharmacy interactions. Limitations were identified regarding the high workload of pharmacists, but particularly their lack of know-how and experience in dealing with information systems (IST) for the provision of pharmaceutical services. This paper summarizes a research project in which an online pharmaceutical service was proposed, designed, developed

  4. BRIC-100VC Biological Research in Canisters (BRIC)-100VC

    Science.gov (United States)

    Richards, Stephanie E.; Levine, Howard G. (Compiler); Romero, Vergel

    2016-01-01

    The Biological Research in Canisters (BRIC) is an anodized-aluminum cylinder used to provide passive stowage for investigations of the effects of space flight on small specimens. The BRIC 100 mm petri dish vacuum containment unit (BRIC-100VC) has supported Dugesia japonica (flatworm) within spring under normal atmospheric conditions for 29 days in space and Hemerocallis lilioasphodelus L. (daylily) somatic embryo development within a 5% CO2 gaseous environment for 4.5 months in space. BRIC-100VC is a completely sealed, anodized-aluminum cylinder (Fig. 1) providing containment and structural support of the experimental specimens. The top and bottom lids of the canister include rapid disconnect valves for filling the canister with selected gases. These specialized valves allow for specific atmospheric containment within the canister, providing a gaseous environment defined by the investigator. Additionally, the top lid has been designed with a toggle latch and O-ring assembly allowing for prompt sealing and removal of the lid. The outside dimensions of the BRIC-100VC canisters are 16.0 cm (height) x 11.4 cm (outside diameter). The lower portion of the canister has been equipped with sufficient storage space for passive temperature and relative humidity data loggers. The BRIC- 100VC canister has been optimized to accommodate standard 100 mm laboratory petri dishes or 50 mL conical tubes. Depending on storage orientation, up to 6 or 9 canisters have been flown within an International Space Station (ISS) stowage locker.

  5. Gross's anatomy: textual politics in science/biology education research

    Science.gov (United States)

    Reis, Giuliano

    2009-12-01

    In approaching how the grotesque is—or should be—situated within contemporary science (biology) education practices, Weinstein and Broda undertake a passionate reclaim of an education that is at the same time scientific, critical, and liberatory. However legitimate, their work offers more than they probably could have anticipated: It exemplifies how the textual structure of a research article can be such as to "tip-off" readers about how it is supposed to be understood. In this way, what one learns from reading the manuscript is grounded on the way the authors examine the data presented. That is, the findings are not intrinsic to the materials collected, but constructed within the analyses that precede/follow the account of each one of the four "specimens" reported. Therefore, the present commentary seeks to re-consider the original study from an alternative perspective, one that challenges its seemingly objective (re)construction of facts by placing emphasis on how the text contains instructions for its own interpretation and validation. Ultimately, the purpose here is to describe and discuss the interpretive and validation work that is done by this discursive mechanism of self-appraisal rather than discredit the two authors' initiative.

  6. Using Biological-Control Research in the Classroom to Promote Scientific Inquiry & Literacy

    Science.gov (United States)

    Richardson, Matthew L.; Richardson, Scott L.; Hall, David G.

    2012-01-01

    Scientists researching biological control should engage in education because translating research programs into classroom activities is a pathway to increase scientific literacy among students. Classroom activities focused on biological control target all levels of biological organization and can be cross-disciplinary by drawing from subject areas…

  7. Making research relevant? Ecological methods and the ecosystem services framework

    Science.gov (United States)

    Root-Bernstein, Meredith; Jaksic, Fabián. M.

    2017-07-01

    We examine some unexpected epistemological conflicts that arise at the interfaces between ecological science, the ecosystem services framework, policy, and industry. We use an example from our own research to motivate and illustrate our main arguments, while also reviewing standard approaches to ecological science using the ecosystem services framework. While we agree that the ecosystem services framework has benefits in its industrial applications because it may force economic decision makers to consider a broader range of costs and benefits than they would do otherwise, we find that many alignments of ecology with the ecosystem services framework are asking questions that are irrelevant to real-world applications, and generating data that does not serve real-world applications. We attempt to clarify why these problems arise and how to avoid them. We urge fellow ecologists to reflect on the kind of research that can lead to both scientific advances and applied relevance to society. In our view, traditional empirical approaches at landscape scales or with place-based emphases are necessary to provide applied knowledge for problem solving, which is needed once decision makers identify risks to ecosystem services. We conclude that the ecosystem services framework is a good policy tool when applied to decision-making contexts, but not a good theory either of social valuation or ecological interactions, and should not be treated as one.

  8. LiGA Research and Service at CAMD

    International Nuclear Information System (INIS)

    Goettert, Jost; Datta, Proyag; Desta, Yohannes; Jin, Yoonyoung; Ling Zhonggeng; Singh, Varshni

    2006-01-01

    Since 1995 CAMD has been offering exposure services, so called print shop for a variety of users interested in making precision High-Aspect-Ratio Microstructures (HARMST) for various application. Services have been expanded beyond only the print shop service in recent years and now include x-ray mask fabrication, substrate preparation for PMMA and SU- 8 resists, electroplating, finishing and molding. Metallic and polymeric parts are now routinely fabricated for precision engineering, micro-fluidic and micro-optic applications. This paper presents a brief overview of the actual status of LiGA services provided at CAMD including ongoing research efforts and examples of LiGA components for different applications

  9. The progress of molecular biology in radiation research

    International Nuclear Information System (INIS)

    Wei Kang

    1989-01-01

    The recent progress in application of molecular biology techniques in the study of radiation biology is reviewed. The three sections are as follows: (1) the study of DNA damage on molecular level, (2) the molecular mechanism of radiation cell genetics, including chromosome abberation and cell mutation, (3) the study on DNA repair gene with DNA mediated gene transfer techniques

  10. Research Update: Interfacing ultrasmall metal nanoclusters with biological systems

    Science.gov (United States)

    Shang, Li; Nienhaus, G. Ulrich

    2017-05-01

    Metal nanoclusters (NCs), a new type of nanomaterial with unique physicochemical properties, show great potential in many biomedical applications. Understanding their behavior in the complex biological environment is critical not only for designing highly efficient NC-based nanomedicines but also for elucidating the biological impact (e.g., toxicity) of these emerging nanomaterials. In this review, we give an overview of recent progress in exploring interactions of metal NCs with biological systems, including protein adsorption onto NCs, NC interactions with cells, and also the in vivo behavior of NCs. We also discuss the biological responses to the interactions, key parameters defining the interactions, and current challenges in the exploration of NCs in the complex biological environment.

  11. An interoperable research data infrastructure to support climate service development

    Science.gov (United States)

    De Filippis, Tiziana; Rocchi, Leandro; Rapisardi, Elena

    2018-02-01

    Accessibility, availability, re-use and re-distribution of scientific data are prerequisites to build climate services across Europe. From this perspective the Institute of Biometeorology of the National Research Council (IBIMET-CNR), aiming at contributing to the sharing and integration of research data, has developed a research data infrastructure to support the scientific activities conducted in several national and international research projects. The proposed architecture uses open-source tools to ensure sustainability in the development and deployment of Web applications with geographic features and data analysis functionalities. The spatial data infrastructure components are organized in typical client-server architecture and interact from the data provider download data process to representation of the results to end users. The availability of structured raw data as customized information paves the way for building climate service purveyors to support adaptation, mitigation and risk management at different scales.This work is a bottom-up collaborative initiative between different IBIMET-CNR research units (e.g. geomatics and information and communication technology - ICT; agricultural sustainability; international cooperation in least developed countries - LDCs) that embrace the same approach for sharing and re-use of research data and informatics solutions based on co-design, co-development and co-evaluation among different actors to support the production and application of climate services. During the development phase of Web applications, different users (internal and external) were involved in the whole process so as to better define user needs and suggest the implementation of specific custom functionalities. Indeed, the services are addressed to researchers, academics, public institutions and agencies - practitioners who can access data and findings from recent research in the field of applied meteorology and climatology.

  12. An interoperable research data infrastructure to support climate service development

    Directory of Open Access Journals (Sweden)

    T. De Filippis

    2018-02-01

    Full Text Available Accessibility, availability, re-use and re-distribution of scientific data are prerequisites to build climate services across Europe. From this perspective the Institute of Biometeorology of the National Research Council (IBIMET-CNR, aiming at contributing to the sharing and integration of research data, has developed a research data infrastructure to support the scientific activities conducted in several national and international research projects. The proposed architecture uses open-source tools to ensure sustainability in the development and deployment of Web applications with geographic features and data analysis functionalities. The spatial data infrastructure components are organized in typical client–server architecture and interact from the data provider download data process to representation of the results to end users. The availability of structured raw data as customized information paves the way for building climate service purveyors to support adaptation, mitigation and risk management at different scales.This work is a bottom-up collaborative initiative between different IBIMET-CNR research units (e.g. geomatics and information and communication technology – ICT; agricultural sustainability; international cooperation in least developed countries – LDCs that embrace the same approach for sharing and re-use of research data and informatics solutions based on co-design, co-development and co-evaluation among different actors to support the production and application of climate services. During the development phase of Web applications, different users (internal and external were involved in the whole process so as to better define user needs and suggest the implementation of specific custom functionalities. Indeed, the services are addressed to researchers, academics, public institutions and agencies – practitioners who can access data and findings from recent research in the field of applied meteorology and climatology.

  13. Technical Services Research Needs for the 1990s.

    Science.gov (United States)

    Veaner, Allen B.

    1983-01-01

    Research needs in area of library technical services are identified, focusing on costs, the catalog, bibliographic data, new cataloging code, subject access in online catalogs, acquisitions, serials control system, universal technical processing terminals, data storage devices, robots and artificial intelligence, bibliographic instruction, and…

  14. Taxonomy for the Network and Service Management Research Field

    NARCIS (Netherlands)

    Raniery Paula dos Santos, Carlos; Famaey, Jeroen; Schönwälder, Jürgen; Zambenedetti Granville, Lisandro; Pras, Aiko; De Turck, Filip

    Network and service management has established itself as a research field in the general area of computer networks. However, up to now, no appropriate organization of the field has been carried out in terms of a comprehensive list of terms and topics. In this paper, we introduce a taxonomy for

  15. Research into Learning Resulting from Quality School Library Media Service.

    Science.gov (United States)

    Marchant, Maurice P.; And Others

    1984-01-01

    This annotated bibliography of 20 research reports identifies what has been determined about the effects of library media services on learning and suggests methodologies available for similar studies. Organization is according to area of learning affected--academic achievement; language, reading, and library skills; mathematics; science; social…

  16. Interrelations for Teaching, Research, and Service: The Faculty Satisfaction Dilemma.

    Science.gov (United States)

    Serafin, Ana Gil

    This study investigated the extent of the interrelations of faculty satisfaction with the position functions of teaching, research, and service across Venezuelan teacher college campuses. In particular the study concerned the extent to which the variations in the variable teaching satisfaction were associated with the variations in the variables…

  17. Collaboration: Perceptions of FCS Professionals in Teaching, Research, and Service

    Science.gov (United States)

    Kandiah, Jay; Saiki, Diana

    2012-01-01

    The purpose of this study is to investigate family and consumer sciences (FCS) professionals' perceptions of multidisciplinary collaboration in teaching, research, and service. A focus group and survey were participants identified projects, strengths, weaknesses, and suggestions related to collaboration.Topics and projects that incorporated…

  18. Research and service programs in the PHS: challenges in organization

    National Research Council Canada - National Science Library

    Institute of Medicine Staff; Institute of Medicine

    1991-01-01

    ... Committee on Co-Administration of Service and Research Programs of the National Institutes of Health, the Alcohol, Drug Abuse, and Mental Health Administration, and Related Agencies INSTITUTE OF MEDICINE NATIONAL ACADEMY PRESS Washington, D.C. 1991 Copyrightoriginal retained, the be not from cannot book, paper original however, for version formatting, author...

  19. Biology panel: coming to a clinic near you. Translational research in radiation biology

    International Nuclear Information System (INIS)

    Travis, Elizabeth L.; Thames, Howard D.

    1996-01-01

    The explosion of knowledge in molecular biology coupled with the rapid and continuing development of molecular techniques allow a new level of research in radiation biology aimed at understanding the processes that govern radiation damage and response in both tumors and normal tissues. The challenge to radiation biologists and radiation oncologists is to use this knowledge to improve the therapeutic ratio in the management of human tumors by rapidly translating these new findings into clinical practice. This panel will focus on both sides of the therapeutic ratio coin, the manipulation of tumor control by manipulating the processes that control cell cycle regulation and apoptosis, and the reduction of normal tissue morbidity by applying the emerging information on the genetic basis of radiosensitivity. Apoptosis is a form of cell death believed to represent a minor component of the clinical effects of radiation. However, if apoptosis is regulated by anti-apoptotic mechanisms, then it may be possible to produce a pro-apoptotic phenotype in the tumor cell population by modulating the balance between pro- and anti-apoptotic mechanisms by pharmacological intervention. Thus signaling-based apoptosis therapy, designed to overcome the relative resistance to radiation-induced apoptosis, may improve the therapeutic ratio in the management of human tumors. The explosion of information concerning cell cycle regulation in both normal and tumor cells has provided the opportunity for insights into the mechanism of action of chemotherapeutic agents that can act as radiosensitizers. The second talk will explore the hypothesis that the dysregulation of cell cycle checkpoints in some cancers can be exploited to improve the therapeutic index of radiation sensitizers, specifically the fluoropyrimidines which appear to act at the G1/S transition. Finally, efforts to increase tumor control will be translated into clinical practice only if such treatments do not increase the complication

  20. 75 FR 65404 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-10-22

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... & Regenerative Medicine Subcommittee of the Rehabilitation Research and Development Service Scientific Merit..., examination, reference to, [[Page 65405

  1. BrisSynBio: a BBSRC/EPSRC-funded Synthetic Biology Research Centre.

    Science.gov (United States)

    Sedgley, Kathleen R; Race, Paul R; Woolfson, Derek N

    2016-06-15

    BrisSynBio is the Bristol-based Biotechnology and Biological Sciences Research Council (BBSRC)/Engineering and Physical Sciences Research Council (EPSRC)-funded Synthetic Biology Research Centre. It is one of six such Centres in the U.K. BrisSynBio's emphasis is on rational and predictive bimolecular modelling, design and engineering in the context of synthetic biology. It trains the next generation of synthetic biologists in these approaches, to facilitate translation of fundamental synthetic biology research to industry and the clinic, and to do this within an innovative and responsible research framework. © 2016 The Author(s).

  2. Biological research work within the Association of the Government-Sponsored Research Institutions (AGF)

    International Nuclear Information System (INIS)

    1991-01-01

    Six of the thirteen government-sponsored research institutions in the Federal Republic of Germany carry out research work for the protection of the population against the harmful effects of ionizing radiation. Their activities in this field concentrate on the following four points of main interest: analysis of radiation-induced processes resulting in biological radiation injury; description and analysis of complex radiation effects on man; medical applications of ionizing radiation for diagnosis and therapy; concepts and methods for radiological protection. The work reported reviews the main problems encountered in the above-mentioned subject fields and presents examples of significant results, with illustrations. The original research papers and their authors are listed separately under the four points of main interest. (orig./MG) [de

  3. Applications of neutron scattering in molecular biological research

    International Nuclear Information System (INIS)

    Nierhaus, K.H.

    1984-01-01

    The study of the molecular structure of biological materials by neutron scattering is described. As example the results of the study of the components of a ribosome of Escherichia coli are presented. (HSI) [de

  4. 78 FR 63170 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2013-10-23

    ....-12:15 p.m. ADDRESSES: Hilton Washington DC/Rockville Hotel & Executive Meeting Center, 1750 Rockville... Biological and Environmental Grand Challenges Workshop Reports Science Talks New Business Public Comment...

  5. Tumor Biology and Immunology | Center for Cancer Research

    Science.gov (United States)

    Tumor Biology and Immunology The Comparative Brain Tumor Consortium is collaborating with National Center for Advanced Translational Sciences to complete whole exome sequencing on canine meningioma samples. Results will be published and made publicly available.

  6. Biometry: the principles and practice of statistics in biological research

    National Research Council Canada - National Science Library

    Sokal, R.R; Rohlf, F.J

    1969-01-01

    In this introductory textbook, with its companion volume of tables, the authors provide a balanced presentation of statistical methodology for the descriptive, experimental, and analytical study of biological phenomena...

  7. NATO Advanced Research Institute on Health Services Systems

    CERN Document Server

    Werff, Albert; Hirsch, Gary; Barnard, Keith

    1984-01-01

    The Advanced Research Institute on "Health Services Systems" was held under the auspices of the NATO Special Programme Panel on Systems Science as a part of the NATO Science Committee's continuous effort to promote the advancement of science through international cooperation. A special word is said in this respect supra by Pro­ fessor Checkland, Chairman of the Systems Science Panel. The Advanced Research Institute (ARI) was organized for the purpose of bringing together senior scientists to seek a consensus on the assessment of the present state of knowledge on the specific topic of "health services systems" and to present views and recom­ mendations for future health services research directions, which should be of value to both the scientific community and the people in charge of reorienting health services. The conference was structured so as to permit the assembly of a variety of complementary viewpoints through intensive group discussions to be the basis of this final report. Invitees were selected fr...

  8. Conceptualising spirituality for medical research and health service provision

    Directory of Open Access Journals (Sweden)

    Koenig Harold G

    2009-07-01

    Full Text Available Abstract The need to take account of spirituality in research and health services provision is assuming ever greater importance. However the field has long been hampered by a lack of conceptual clarity about the nature of spirituality itself. We do not agree with the sceptical claim that it is impossible to conceptualise spirituality within a scientific paradigm. Our aims are to 1 provide a brief over-view of critical thinking that might form the basis for a useful definition of spirituality for research and clinical work and 2 demystify the language of spirituality for clinical practice and research.

  9. Service quality as goal and outcome of ergonomics research

    DEFF Research Database (Denmark)

    Sørensen, Ole Henning

    2014-01-01

    and service quality. The study conducted an employee survey with 754 preschool teachers in 98 Danish preschools and a user survey among 8116 parents. Significant correlations were found between well-being and service quality measures from both employees and users indicating a link between traditional......Ergonomics research needs to design organizational level, occupational health interventions that contribute to improving organizational performance so as to become of practical relevance for management. This paper analyses a study evaluating the impact of such interventions on user satisfaction...

  10. Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Wallner, Paul E., E-mail: pwallner@theabr.org [21st Century Oncology, LLC, and the American Board of Radiology, Bethesda, Maryland (United States); Anscher, Mitchell S. [Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia (United States); Barker, Christopher A. [Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York (United States); Bassetti, Michael [Department of Human Oncology, University of Wisconsin Carbone Cancer Center, Madison, Wisconsin (United States); Bristow, Robert G. [Departments of Radiation Oncology and Medical Biophysics, Princess Margaret Cancer Center/University of Toronto, Toronto, Ontario (Canada); Cha, Yong I. [Department of Radiation Oncology, Norton Cancer Center, Louisville, Kentucky (United States); Dicker, Adam P. [Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania (United States); Formenti, Silvia C. [Department of Radiation Oncology, New York University, New York, New York (United States); Graves, Edward E. [Departments of Radiation Oncology and Radiology, Stanford University, Stanford, California (United States); Hahn, Stephen M. [Department of Radiation Oncology, University of Pennsylvania (United States); Hei, Tom K. [Center for Radiation Research, Columbia University, New York, New York (United States); Kimmelman, Alec C. [Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Kirsch, David G. [Department of Radiation Oncology, Duke University, Durham, North Carolina (United States); Kozak, Kevin R. [Department of Human Oncology, University of Wisconsin (United States); Lawrence, Theodore S. [Department of Radiation Oncology, University of Michigan (United States); Marples, Brian [Department of Radiation Oncology, Oakland University, Oakland, California (United States); and others

    2014-01-01

    In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report.

  11. Current status and recommendations for the future of research, teaching, and testing in the biological sciences of radiation oncology: report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, executive summary.

    Science.gov (United States)

    Wallner, Paul E; Anscher, Mitchell S; Barker, Christopher A; Bassetti, Michael; Bristow, Robert G; Cha, Yong I; Dicker, Adam P; Formenti, Silvia C; Graves, Edward E; Hahn, Stephen M; Hei, Tom K; Kimmelman, Alec C; Kirsch, David G; Kozak, Kevin R; Lawrence, Theodore S; Marples, Brian; McBride, William H; Mikkelsen, Ross B; Park, Catherine C; Weidhaas, Joanne B; Zietman, Anthony L; Steinberg, Michael

    2014-01-01

    In early 2011, a dialogue was initiated within the Board of Directors (BOD) of the American Society for Radiation Oncology (ASTRO) regarding the future of the basic sciences of the specialty, primarily focused on the current state and potential future direction of basic research within radiation oncology. After consideration of the complexity of the issues involved and the precise nature of the undertaking, in August 2011, the BOD empanelled a Cancer Biology/Radiation Biology Task Force (TF). The TF was charged with developing an accurate snapshot of the current state of basic (preclinical) research in radiation oncology from the perspective of relevance to the modern clinical practice of radiation oncology as well as the education of our trainees and attending physicians in the biological sciences. The TF was further charged with making suggestions as to critical areas of biological basic research investigation that might be most likely to maintain and build further the scientific foundation and vitality of radiation oncology as an independent and vibrant medical specialty. It was not within the scope of service of the TF to consider the quality of ongoing research efforts within the broader radiation oncology space, to presume to consider their future potential, or to discourage in any way the investigators committed to areas of interest other than those targeted. The TF charge specifically precluded consideration of research issues related to technology, physics, or clinical investigations. This document represents an Executive Summary of the Task Force report. Copyright © 2014 Elsevier Inc. All rights reserved.

  12. Areas of research in radiation chemistry fundamental to radiation biology

    International Nuclear Information System (INIS)

    Powers, E.L.

    1980-01-01

    Among all the environmental hazards to which man is exposed, ionizing radiation is the most thoroughly investigated and the most responsibly monitored and controlled. Nevertheless, because of the importance of radiation in modern society from both the hazard as well as the utilitarian standpoints, much more information concerning the biological effects induced and their modification and reversal is required. Together with radiation physics, an understanding of radiation chemistry is necessary for full appreciation of biological effects of high and low energy radiations, and for the development of prophylactic, therapeutic and potentiating methods and techniques in biological organisms. The necessity of understanding the chemistry of any system, biological or not, that is to be manipulated and controlled, is so obvious as to make trivial a statement to that effect. If any natural phenomenon is to be put to our use, surely the elements of it must be studied and appreciated fully. In the preliminary statements of the various panels of this general group, the need for additional information on the basic radiation chemistry concerned in radiation-induced biological effects pervades throughout

  13. 77 FR 40412 - Rehabilitation Research and Development Service Scientific Merit Review Board, Notice of Meeting

    Science.gov (United States)

    2012-07-09

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit..., Rehabilitation Research and Development Service, and the Chief Research and Development Officer on the scientific...-463 (Federal Advisory Committee Act) that subcommittees of the Rehabilitation Research and Development...

  14. 77 FR 9731 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2012-02-17

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit..., Rehabilitation Research and Development Service, and the Chief Research and Development Officer on the scientific...-463 (Federal Advisory Committee Act) that a meeting of the Rehabilitation Research and Development...

  15. Creating and supporting a mixed methods health services research team.

    Science.gov (United States)

    Bowers, Barbara; Cohen, Lauren W; Elliot, Amy E; Grabowski, David C; Fishman, Nancy W; Sharkey, Siobhan S; Zimmerman, Sheryl; Horn, Susan D; Kemper, Peter

    2013-12-01

    To use the experience from a health services research evaluation to provide guidance in team development for mixed methods research. The Research Initiative Valuing Eldercare (THRIVE) team was organized by the Robert Wood Johnson Foundation to evaluate The Green House nursing home culture change program. This article describes the development of the research team and provides insights into how funders might engage with mixed methods research teams to maximize the value of the team. Like many mixed methods collaborations, the THRIVE team consisted of researchers from diverse disciplines, embracing diverse methodologies, and operating under a framework of nonhierarchical, shared leadership that required new collaborations, engagement, and commitment in the context of finite resources. Strategies to overcome these potential obstacles and achieve success included implementation of a Coordinating Center, dedicated time for planning and collaborating across researchers and methodologies, funded support for in-person meetings, and creative optimization of resources. Challenges are inevitably present in the formation and operation of effective mixed methods research teams. However, funders and research teams can implement strategies to promote success. © Health Research and Educational Trust.

  16. Making Research Fly in Schools: "Drosophila" as a Powerful Modern Tool for Teaching Biology

    Science.gov (United States)

    Harbottle, Jennifer; Strangward, Patrick; Alnuamaani, Catherine; Lawes, Surita; Patel, Sanjai; Prokop, Andreas

    2016-01-01

    The "droso4schools" project aims to introduce the fruit fly "Drosophila" as a powerful modern teaching tool to convey curriculum-relevant specifications in biology lessons. Flies are easy and cheap to breed and have been at the forefront of biology research for a century, providing unique conceptual understanding of biology and…

  17. What Can We Learn from Bioactivity Data? Chemoinformatics Tools and Applications in Chemical Biology Research.

    Science.gov (United States)

    Humbeck, Lina; Koch, Oliver

    2017-01-20

    The ever increasing bioactivity data that are produced nowadays allow exhaustive data mining and knowledge discovery approaches that change chemical biology research. A wealth of chemoinformatics tools, web services, and applications therefore exists that supports a careful evaluation and analysis of experimental data to draw conclusions that can influence the further development of chemical probes and potential lead structures. This review focuses on open-source approaches that can be handled by scientists who are not familiar with computational methods having no expert knowledge in chemoinformatics and modeling. Our aim is to present an easily manageable toolbox for support of every day laboratory work. This includes, among other things, the available bioactivity and related molecule databases as well as tools to handle and analyze in-house data.

  18. Integrated modelling of ecosystem services and energy systems research

    Science.gov (United States)

    Agarwala, Matthew; Lovett, Andrew; Bateman, Ian; Day, Brett; Agnolucci, Paolo; Ziv, Guy

    2016-04-01

    The UK Government is formally committed to reducing carbon emissions and protecting and improving natural capital and the environment. However, actually delivering on these objectives requires an integrated approach to addressing two parallel challenges: de-carbonising future energy system pathways; and safeguarding natural capital to ensure the continued flow of ecosystem services. Although both emphasise benefiting from natural resources, efforts to connect natural capital and energy systems research have been limited, meaning opportunities to improve management of natural resources and meet society's energy needs could be missed. The ecosystem services paradigm provides a consistent conceptual framework that applies in multiple disciplines across the natural and economic sciences, and facilitates collaboration between them. At the forefront of the field, integrated ecosystem service - economy models have guided public- and private-sector decision making at all levels. Models vary in sophistication from simple spreadsheet tools to complex software packages integrating biophysical, GIS and economic models and draw upon many fields, including ecology, hydrology, geography, systems theory, economics and the social sciences. They also differ in their ability to value changes in natural capital and ecosystem services at various spatial and temporal scales. Despite these differences, current models share a common feature: their treatment of energy systems is superficial at best. In contrast, energy systems research has no widely adopted, unifying conceptual framework that organises thinking about key system components and interactions. Instead, the literature is organised around modelling approaches, including life cycle analyses, econometric investigations, linear programming and computable general equilibrium models. However, some consistencies do emerge. First, often contain a linear set of steps, from exploration to resource supply, fuel processing, conversion

  19. Electron Microscopy Facility for Research and Services in the Malaysian Nuclear Agency towards TSO

    International Nuclear Information System (INIS)

    Nadira Kamarudin; Mohd Bin Harun; Zaiton Selamat

    2011-01-01

    Scanning Electron Microscope FEI-Quanta 400 (SEM) made in the USA was commissioned in late 2003. This equipment is used in many areas of materials science, metallurgy, engineering, electronics, medicine, agriculture, biology and so on. This facility has helped the researchers in conducting research in their respective fields as well have been providing services to agencies, institutions, industries and local industry. Since 2004, there were 81 projects and 5000 samples analyzed using this facility in Malaysian Nuclear Agency, while 23 companies and 900 samples were from various agencies. In addition, revenue derived from these services has able to provide for the maintenance of this equipment. SEM is an important step in the nuclear material testing process. Nuclear material can be inspected for its performance by getting information from its morphology micrograph by using SEM. It opens up a whole new world that is unseen by the naked eye. (author)

  20. Researcher-decision-maker partnerships in health services research: Practical challenges, guiding principles

    Science.gov (United States)

    2012-01-01

    Background In health services research, there is a growing view that partnerships between researchers and decision-makers (i.e., collaborative research teams) will enhance the effective translation and use of research results into policy and practice. For this reason, there is an increasing expectation by health research funding agencies that health system managers, policy-makers, practitioners and clinicians will be members of funded research teams. While this view has merit to improve the uptake of research findings, the practical challenges of building and sustaining collaborative research teams with members from both inside and outside the research setting requires consideration. A small body of literature has discussed issues that may arise when conducting research in one’s own setting; however, there is a lack of clear guidance to deal with practical challenges that may arise in research teams that include team members who have links with the organization/community being studied (i.e., are “insiders”). Discussion In this article, we discuss a researcher-decision-maker partnership that investigated practice in primary care networks in Alberta. Specifically, we report on processes to guide the role clarification of insider team members where research activities may pose potential risk to participants or the team members (e.g., access to raw data). Summary These guiding principles could provide a useful discussion point for researchers and decision-makers engaged in health services research. PMID:22928979

  1. Researcher-decision-maker partnerships in health services research: Practical challenges, guiding principles

    Directory of Open Access Journals (Sweden)

    Hofmeyer Anne

    2012-08-01

    Full Text Available Abstract Background In health services research, there is a growing view that partnerships between researchers and decision-makers (i.e., collaborative research teams will enhance the effective translation and use of research results into policy and practice. For this reason, there is an increasing expectation by health research funding agencies that health system managers, policy-makers, practitioners and clinicians will be members of funded research teams. While this view has merit to improve the uptake of research findings, the practical challenges of building and sustaining collaborative research teams with members from both inside and outside the research setting requires consideration. A small body of literature has discussed issues that may arise when conducting research in one’s own setting; however, there is a lack of clear guidance to deal with practical challenges that may arise in research teams that include team members who have links with the organization/community being studied (i.e., are “insiders”. Discussion In this article, we discuss a researcher-decision-maker partnership that investigated practice in primary care networks in Alberta. Specifically, we report on processes to guide the role clarification of insider team members where research activities may pose potential risk to participants or the team members (e.g., access to raw data. Summary These guiding principles could provide a useful discussion point for researchers and decision-makers engaged in health services research.

  2. Personal recollections of radiation biology research at Hanford

    International Nuclear Information System (INIS)

    Thompson, R.C.

    1995-01-01

    This paper traces the evolution of the Hanford biology programme over a period of nearly five decades. The programme began in the 1940s with a focus on understanding the potential health effects of radionuclides such as 131 I associated with fallout from the atomic bomb. These studies were extended in the 1950s to experiments on the toxicity and metabolism of plutonium and fission products such as 90 Sr and 137 Cs. In the 1960s, a major long term project was initiated on the inhalation toxicology and carcinogenic effects of plutonium oxide and plutonium nitrate in dogs and rodents. The project remained a major effort within the overall Hanford biology programme throughout the 1970s and 1980s, during which time a broad range of new projects on energy-related pollutants, radon health effects, and basic radiation biology were initiated. Despite the many evolutionary changes that have occurred in the Hanford biology programme, the fundamental mission of understanding the effects of radiation on human health has endured for nearly five decades. (author)

  3. Introduction to basic molecular biologic techniques for molecular imaging researches

    International Nuclear Information System (INIS)

    Kang, Joo Hyun

    2004-01-01

    Molecular imaging is a rapidly growing field due to the advances in molecular biology and imaging technologies. With the introduction of imaging reporter genes into the cell, diverse cellular processes can be monitored, quantified and imaged non-invasively in vivo. These processes include the gene expression, protein-protein interactions, signal transduction pathways, and monitoring of cells such as cancer cells, immune cells, and stem cells. In the near future, molecular imaging analysis will allow us to observe the incipience and progression of the disease. These will make us easier to give a diagnosis in the early stage of intractable diseases such as cancer, neuro-degenerative disease, and immunological disorders. Additionally, molecular imaging method will be a valuable tool for the real-time evaluation of cells in molecular biology and the basic biological studies. As newer and more powerful molecular imaging tools become available, it will be necessary to corporate clinicians, molecular biologists and biochemists for the planning, interpretation, and application of these techniques to their fullest potential. In order for such a multidisciplinary team to be effective, it is essential that a common understanding of basic biochemical and molecular biologic techniques is achieved. Basic molecular techniques for molecular imaging methods are presented in this paper

  4. Gross's Anatomy: Textual Politics in Science/Biology Education Research

    Science.gov (United States)

    Reis, Giuliano

    2009-01-01

    In approaching how the grotesque is--or should be--situated within contemporary science (biology) education practices, Weinstein and Broda undertake a passionate reclaim of an education that is at the same time scientific, critical, and liberatory. However legitimate, their work offers more than they probably could have anticipated: It exemplifies…

  5. The Prospects For Research In Biological Psychiatry In Nigeria ...

    African Journals Online (AJOL)

    Biological psychiatry deals with abnormalities of brain and genetic functioning and how they interact with environmental factors to underlie the genesis, manifestation, and response to treatment of mental disorders. These issues have not featured significantly in the Nigerian psychiatric scene. Hence, we are witnessing a ...

  6. Update on the Health Services Research Doctoral Core Competencies.

    Science.gov (United States)

    Burgess, James F; Menachemi, Nir; Maciejewski, Matthew L

    2018-03-13

    To present revised core competencies for doctoral programs in health services research (HSR), modalities to deliver these competencies, and suggested methods for assessing mastery of these competencies. Core competencies were originally developed in 2005, updated (but unpublished) in 2008, modestly updated for a 2016 HSR workforce conference, and revised based on feedback from attendees. Additional feedback was obtained from doctoral program directors, employer/workforce experts and attendees of presentation on these competencies at the AcademyHealth's June 2017 Annual Research Meeting. The current version (V2.1) competencies include the ethical conduct of research, conceptual models, development of research questions, study designs, data measurement and collection methods, statistical methods for analyzing data, professional collaboration, and knowledge dissemination. These competencies represent a core that defines what HSR researchers should master in order to address the complexities of microsystem to macro-system research that HSR entails. There are opportunities to conduct formal evaluation of newer delivery modalities (e.g., flipped classrooms) and to integrate new Learning Health System Researcher Core Competencies, developed by AHRQ, into the HSR core competencies. Core competencies in HSR are a continually evolving work in progress because new research questions arise, new methods are developed, and the trans-disciplinary nature of the field leads to new multidisciplinary and team building needs. © Health Research and Educational Trust.

  7. Creating and Supporting a Mixed Methods Health Services Research Team

    Science.gov (United States)

    Bowers, Barbara; Cohen, Lauren W; Elliot, Amy E; Grabowski, David C; Fishman, Nancy W; Sharkey, Siobhan S; Zimmerman, Sheryl; Horn, Susan D; Kemper, Peter

    2013-01-01

    Objective. To use the experience from a health services research evaluation to provide guidance in team development for mixed methods research. Methods. The Research Initiative Valuing Eldercare (THRIVE) team was organized by the Robert Wood Johnson Foundation to evaluate The Green House nursing home culture change program. This article describes the development of the research team and provides insights into how funders might engage with mixed methods research teams to maximize the value of the team. Results. Like many mixed methods collaborations, the THRIVE team consisted of researchers from diverse disciplines, embracing diverse methodologies, and operating under a framework of nonhierarchical, shared leadership that required new collaborations, engagement, and commitment in the context of finite resources. Strategies to overcome these potential obstacles and achieve success included implementation of a Coordinating Center, dedicated time for planning and collaborating across researchers and methodologies, funded support for in-person meetings, and creative optimization of resources. Conclusions. Challenges are inevitably present in the formation and operation of effective mixed methods research teams. However, funders and research teams can implement strategies to promote success. PMID:24138774

  8. Identifying future research directions for biodiversity, ecosystem services and sustainability : perspectives from early-career researchers

    NARCIS (Netherlands)

    Hossain, S.; Pogue, S.J.; Trenchard, L.; Oudenhoven, van A.P.E.; Washbourne, C-L.; Muiruri, E.W.; Tomczyk, A.M.; García-Llorente, M.; Hale, R.; Hevia, V.; Adams, T.; Tavallali, L.; De, Bell S.; Pye, M.; Resende, F.

    2017-01-01

    We aimed to identify priority research questions in the field of biodiversity, ecosystem services and sustainability (BESS), based on a workshop held during the NRG BESS Conference for Early Career Researchers on BESS, and to compare these to existing horizon scanning exercises. This work highlights

  9. Supported Accommodation Services for Offenders:A Research Literature Review

    OpenAIRE

    Kirkwood, Steve; Richley, Tim

    2008-01-01

    This paper examines the links between homelessness and offending and provides a description of supported accommodation services provided by Sacro for offenders in Scotland and a summary of some of the main findings from research on the impact of supported accommodation for offenders. Finally, the paper identifies a set of ‘critical issues’ for the consideration of practitioners that arise from the research and which may hinder the ability of the ex-offender to ‘move on’. These critical issues a...

  10. A Trust Framework for Online Research Data Services

    Directory of Open Access Journals (Sweden)

    Malcolm Wolski

    2017-06-01

    Full Text Available There is worldwide interest in the potential of open science to increase the quality, impact, and benefits of science and research. More recently, attention has been focused on aspects such as transparency, quality, and provenance, particularly in regard to data. For industry, citizens, and other researchers to participate in the open science agenda, further work needs to be undertaken to establish trust in research environments. Based on a critical review of the literature, this paper examines the issue of trust in an open science environment, using virtual laboratories as the focus for discussion. A trust framework, which has been developed from an end-user perspective, is proposed as a model for addressing relevant issues within online research data services and tools.

  11. Large Scale Computing and Storage Requirements for Biological and Environmental Research

    Energy Technology Data Exchange (ETDEWEB)

    DOE Office of Science, Biological and Environmental Research Program Office (BER),

    2009-09-30

    In May 2009, NERSC, DOE's Office of Advanced Scientific Computing Research (ASCR), and DOE's Office of Biological and Environmental Research (BER) held a workshop to characterize HPC requirements for BER-funded research over the subsequent three to five years. The workshop revealed several key points, in addition to achieving its goal of collecting and characterizing computing requirements. Chief among them: scientific progress in BER-funded research is limited by current allocations of computational resources. Additionally, growth in mission-critical computing -- combined with new requirements for collaborative data manipulation and analysis -- will demand ever increasing computing, storage, network, visualization, reliability and service richness from NERSC. This report expands upon these key points and adds others. It also presents a number of"case studies" as significant representative samples of the needs of science teams within BER. Workshop participants were asked to codify their requirements in this"case study" format, summarizing their science goals, methods of solution, current and 3-5 year computing requirements, and special software and support needs. Participants were also asked to describe their strategy for computing in the highly parallel,"multi-core" environment that is expected to dominate HPC architectures over the next few years.

  12. Consequences of Environmental Service Payments for Forest Retention and Recruitment in a Costa Rican Biological Corridor

    Directory of Open Access Journals (Sweden)

    Wayde C. Morse

    2009-06-01

    Full Text Available Compensation to landowners for forest-derived environmental services has gained international recognition as a mechanism to combat forest loss and fragmentation. This approach is widely promoted, although there is little evidence demonstrating that environmental service payments encourage forest stewardship and conservation. Costa Rica provides a unique case study in which a 1996 Forestry Law initiated environmental service payments and prohibited forest conversion to other land uses. We examined these novel policies to determine their influence on landowner decisions that affect forest change, carbon services, and connectivity in a 2425 km² biological corridor. We used Landsat images to compare land-cover changes before and after 1996, and linked these data to landowner surveys investigating land-use decisions. Carbon stocks and storage in secondary forests were also examined. Forest change observations were corroborated by landowner survey data, indicating that the 1996 Forestry Law and environmental service payments contributed positively to forest retention and recruitment. Socioeconomic conditions also favored forest protection. Rates of natural forest loss declined from -1.43% to -0.10%/yr after 1996. Forest cover and connectivity were maintained through tree plantations and secondary forest recruitment, although forest heterogeneity increased as these forest types sometimes replaced natural forest. Carbon storage in secondary forest approached levels in primary forest after 25-30 yr of succession, although few landowners retained natural regeneration. Secondary forests will persist as minor landscape components without legal or financial incentives. The Costa Rican experience provides evidence that environmental service payments can be effective in retaining natural forest and recruiting tree cover within biological corridors.

  13. Microwave system for research biological effects on laboratory animals

    OpenAIRE

    Kopylov, Alexei; Kruglik, Olga; Khlebopros, Rem

    2014-01-01

    This research is concerned with development of the microwave system for research the radiophysical microwave radiation effects on laboratory animals. The frequency was 1 GHz. The results obtained demonstrate the metabolic changes in mice under the electromagnetic field influence.

  14. Redox Biology Course Registration Form | Center for Cancer Research

    Science.gov (United States)

    The Redox Biology class is open to all NIH/NCI fellows and staff and will be held Septhember 27 - November 8, 2016. The last day to register is: September 21, 2016. The first 100 registrants will be accepted for the class. Those who plan to participate by Video TeleConference should also register so that you can receive the speaker handouts in advance.

  15. Using Biology Education Research and Qualitative Inquiry to Inform Genomic Nursing Education.

    Science.gov (United States)

    Ward, Linda D

    Decades of research in biology education show that learning genetics is difficult and reveals specific sources of learning difficulty. Little is known about how nursing students learn in this domain, although they likely encounter similar difficulties as nonnursing students. Using qualitative approaches, this study investigated challenges to learning genetics among nursing students. Findings indicate that nursing students face learning difficulties already identified among biology students, suggesting that nurse educators might benefit from biology education research.

  16. 76 FR 71045 - Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and...

    Science.gov (United States)

    2011-11-16

    ...] Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and Information... ``Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and Information... period for the notice on its report of scientific and medical literature and information concerning the...

  17. Interdisciplinary Biomathematics: Engaging Undergraduates in Research on the Fringe of Mathematical Biology

    Science.gov (United States)

    Fowler, Kathleen; Luttman, Aaron; Mondal, Sumona

    2013-01-01

    The US National Science Foundation's (NSF's) Undergraduate Biology and Mathematics (UBM) program significantly increased undergraduate research in the biomathematical sciences. We discuss three UBM-funded student research projects at Clarkson University that lie at the intersection of not just mathematics and biology, but also other fields. The…

  18. Planetary Space Weather Services for the Europlanet 2020 Research Infrastructure

    Science.gov (United States)

    André, Nicolas; Grande, Manuel

    2016-04-01

    Under Horizon 2020, the Europlanet 2020 Research Infrastructure (EPN2020-RI) will include an entirely new Virtual Access Service, WP5 VA1 "Planetary Space Weather Services" (PSWS) that will extend the concepts of space weather and space situational awareness to other planets in our Solar System and in particular to spacecraft that voyage through it. VA1 will make five entirely new 'toolkits' accessible to the research community and to industrial partners planning for space missions: a general planetary space weather toolkit, as well as three toolkits dedicated to the following key planetary environments: Mars (in support ExoMars), comets (building on the expected success of the ESA Rosetta mission), and outer planets (in preparation for the ESA JUICE mission to be launched in 2022). This will give the European planetary science community new methods, interfaces, functionalities and/or plugins dedicated to planetary space weather in the tools and models available within the partner institutes. It will also create a novel event-diary toolkit aiming at predicting and detecting planetary events like meteor showers and impacts. A variety of tools (in the form of web applications, standalone software, or numerical models in various degrees of implementation) are available for tracing propagation of planetary and/or solar events through the Solar System and modelling the response of the planetary environment (surfaces, atmospheres, ionospheres, and magnetospheres) to those events. But these tools were not originally designed for planetary event prediction and space weather applications. So WP10 JRA4 "Planetary Space Weather Services" (PSWS) will provide the additional research and tailoring required to apply them for these purposes. The overall objectives of this Joint Research Aactivities will be to review, test, improve and adapt methods and tools available within the partner institutes in order to make prototype planetary event and space weather services operational in

  19. MOLECULAR BIOLOGICAL RESEARCH AT FATAL CONSEQUENCES OF VIRAL MYOCARDITIS

    Directory of Open Access Journals (Sweden)

    Smelyanskaya MV

    2017-03-01

    Full Text Available Introduction. Diagnosis of viral myocarditis, based on the evidence base, is still one of the key problems of the heart disease. The presence of morphological features of the inflammatory process makes it possible to confirm the diagnosis of myocarditis, but, at the same time, the absence of these features is not sufficient to remove this diagnosis. In routine postmortem study of deaths in multidisciplinary (non-infectious hospital myocarditis is stated as a cause of death in 0.2-0.4% of all the autopsies. Mortality in myocarditis depends on the severity of the underlying disease, premorbid background, age and sex composition of the patients. According to different authors, it is very different and ranges from 0.03 to 26%. The aim of the work was to carry out histological and molecular biological studies postmortem material for confirming the etiologic role of herpesviruses with fatal consequences of infectious myocarditis during the observation period 2015-2016 years. Material & methods. The material of pathological heart, vascular endothelium, nerve ganglia, kidneys, liver and pancreas were investigated. Viral antigen detection was performed by fluorescent antibody technique with specific sera labeled with FITC (Dako Corporation, Carpinteria, CA and detection of the viral genome by PCR (in SYNEVO Laboratory. Morphological studies have been conducted in the post-mortem offices of the Kharkov clinical hospitals. Detection of viral genome was performed by PCR using certified commercial kits for detection of nucleotide sequences of herpesviruses «HSV I, II-EPh», «VZV-FL», «EBV-EPh», «CMV-EPh», «HHV VI-Eph», («AmpliSens». Diagnosis was made in «real time» using modern six-channel thermocycler «Rotor Gene 6000» (Qiagen, Germany. The first group consisted of 19 people who died from infectious myocarditis (group 1. The second group (group 2 consisted of 22 dead from complications of other cardiovascular disease. Pathoanatomical

  20. 75 FR 3542 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-01-21

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit... Board is to review rehabilitation research and development applications for scientific and technical...

  1. 75 FR 40036 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-07-13

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... (Federal Advisory Committee Act) that the Rehabilitation Research and Development Service Scientific Merit... is to review rehabilitation research and development applications for scientific and technical merit...

  2. Conducting Online Behavioral Research Using Crowdsourcing Services in Japan.

    Science.gov (United States)

    Majima, Yoshimasa; Nishiyama, Kaoru; Nishihara, Aki; Hata, Ryosuke

    2017-01-01

    Recent research on human behavior has often collected empirical data from the online labor market, through a process known as crowdsourcing. As well as the United States and the major European countries, there are several crowdsourcing services in Japan. For research purpose, Amazon's Mechanical Turk (MTurk) is the widely used platform among those services. Previous validation studies have shown many commonalities between MTurk workers and participants from traditional samples based on not only personality but also performance on reasoning tasks. The present study aims to extend these findings to non-MTurk (i.e., Japanese) crowdsourcing samples in which workers have different ethnic backgrounds from those of MTurk. We conducted three surveys ( N = 426, 453, 167, respectively) designed to compare Japanese crowdsourcing workers and university students in terms of their demographics, personality traits, reasoning skills, and attention to instructions. The results generally align with previous studies and suggest that non-MTurk participants are also eligible for behavioral research. Furthermore, small screen devices are found to impair participants' attention to instructions. Several recommendations concerning this sample are presented.

  3. 77 FR 796 - Meeting of the Advisory Council on Alzheimer's Research, Care, and Services

    Science.gov (United States)

    2012-01-06

    ... HUMAN SERVICES Meeting of the Advisory Council on Alzheimer's Research, Care, and Services AGENCY... announces public meeting of the Advisory Council on Alzheimer's Research, Care, and Services (Advisory..., section 10(a)(1) and (a)(2)). The Advisory Council on Alzheimer's Research, Care, and Services will...

  4. 77 FR 58557 - Meeting of the Advisory Council on Alzheimer's Research, Care, and Services

    Science.gov (United States)

    2012-09-21

    ... HUMAN SERVICES Meeting of the Advisory Council on Alzheimer's Research, Care, and Services AGENCY... announces the public meeting of the Advisory Council on Alzheimer's Research, Care, and Services (Advisory..., section 10(a)(1) and (a)(2)). The Advisory Council on Alzheimer's Research, Care, and Services provides...

  5. 78 FR 38346 - Advisory Council on Alzheimer's Research, Care, and Services; Meeting

    Science.gov (United States)

    2013-06-26

    ... HUMAN SERVICES Advisory Council on Alzheimer's Research, Care, and Services; Meeting AGENCY: Assistant... public meeting of the Advisory Council on Alzheimer's Research, Care, and Services (Advisory Council). The Advisory Council on Alzheimer's Research, Care, and Services provides advice on how to prevent or...

  6. 78 FR 20318 - Advisory Council on Alzheimer's Research, Care, and Services; Meeting

    Science.gov (United States)

    2013-04-04

    ... HUMAN SERVICES Advisory Council on Alzheimer's Research, Care, and Services; Meeting AGENCY: Assistant... public meeting of the Advisory Council on Alzheimer's Research, Care, and Services (Advisory Council). The Advisory Council on Alzheimer's Research, Care, and Services provides advice on how to prevent or...

  7. Social justice and research using human biological material: A ...

    African Journals Online (AJOL)

    AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use · Contact AJOL · News. OTHER RESOURCES... for Researchers · for Journals · for Authors · for Policy Makers · about Open Access · Journal Quality.

  8. Directions in healthcare research: pointers from retailing and services marketing.

    Science.gov (United States)

    Van Rompay, Thomas L J; Tanja-Dijkstra, Karin

    2010-01-01

    Although the importance of the environment in relation to healing processes has been well established, empirical evidence for environmental effects on patient well-being and behavior is sparse. In addition, few attempts have been made to integrate insights from related fields of research such as retailing and services marketing with findings from healthcare studies. In this paper, relevant findings and insights from these domains are discussed. What insights and findings from retailing and services marketing are (potentially) of interest to the healthcare context, and how should one interpret and follow up on these results in healthcare environments? Research in retailing and services marketing indicates that physical environmental factors (i.e., music and scent) and social environmental factors (i.e., crowded conditions) may affect consumer satisfaction and well-being. In addition, environmental effects have been shown to vary with contextual factors (e.g., the type of environment) and consumer needs (e.g., the extent to which consumers value social contact or stimulation in a specific setting). Although the evidence base for environmental factors in health environments is steadily growing, few attempts have been made to integrate findings from both domains. The findings presented indicate that environmental variables such as music and scent can contribute to patient well-being and overall satisfaction. In addition, findings suggest that these variables may be used to counteract the negative effects resulting from crowded conditions in different healthcare units. Taking into account recent developments in the healthcare industry, the importance of creating memorable and pleasant patient experiences is likely to grow in the years to come. Hence, the finding that subtle and relatively inexpensive manipulations may affect patient well-being in profound ways should inspire follow-up research aimed at unraveling the specifics of environmental influences in health

  9. National pathways for suicide prevention and health services research.

    Science.gov (United States)

    Ahmedani, Brian K; Vannoy, Steven

    2014-09-01

    In 2012, the National Action Alliance for Suicide Prevention's Research Prioritization Task Force (RPTF) released a series of Aspirational Goals (AGs) to decrease suicide deaths and attempts. The RPTF asked experts to summarize what was known about particular AGs and to propose research pathways that would help reach them. This manuscript describes what is known about the benefits of access to health care (AG8) and continuity of care (AG9) for individuals at risk for suicide. Research pathways are proposed to address limitations in current knowledge, particularly in U.S. healthcare-based research. Using a three-step process, the expert panel reviewed available literature from electronic databases. For two AGs, the experts summarized the current state of knowledge, determined breakthroughs needed to advance the field, and developed a series of research pathways to achieve prevention goals. Several components of healthcare provision have been found to be associated with reduced suicide ideation, and in some cases they mitigated suicide deaths. Randomized trials are needed to provide more definitive evidence. Breakthroughs that support more comprehensive patient data collection (e.g., real-time surveillance, death record linkage, and patient registries) would facilitate the steps needed to establish research infrastructure so that various interventions could be tested efficiently within various systems of care. Short-term research should examine strategies within the current healthcare systems, and long-term research should investigate models that redesign the health system to prioritize suicide prevention. Evidence exists to support optimism regarding future suicide prevention, but knowledge is limited. Future research is needed on U.S. healthcare services and system enhancements to determine which of these approaches can provide empirical evidence for reducing suicide. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights

  10. Organisation of biological research carried out in the United States by the A.E.C. or under her contract (1960)

    International Nuclear Information System (INIS)

    Pellerin, J.

    1960-01-01

    This report is based on information gathered in the course of a trip to the United States, in November and December 1958 which consisted chiefly of visits to the main biological and medical research laboratories and discussions with the heads of these establishments. A description is given of the general organisation of the Atomic Energy Commission's Division of Biology and Medicine, and of the distribution of responsibility for radiation protection work and for biological, medical and agricultural research amongst the various Services attached to it; this is followed by a more detailed account of the activities carried on in this field at the great national laboratories. Finally, the systems of collaboration set up with external research organisations in the form of research contracts are examined, together with the substantial help provided by the A.E.C. for biological, medical and agricultural research in general, owing to a systematic policy of subsidising the distribution of radioisotopes for this purpose. (author) [fr

  11. Intellectual disability in Africa: implications for research and service development.

    Science.gov (United States)

    McKenzie, Judith Anne; McConkey, Roy; Adnams, Colleen

    2013-09-01

    Although intellectual disability (ID) is probably the largest impairment grouping on the African continent, few indigenous research and evaluation studies have been undertaken. This article is an initial attempt to relate service delivery issues to an African research agenda. We critically analysed the available literature, drawing on academic publications and those of non-governmental agencies. In this process we identified several key issues for further investigation, namely: understanding ID in African contexts, access to education and health care, the provision of appropriate assistance and support, and income generation. We relate our analysis to the recommendations made in the World Report on Disability but with a specific focus on ID in Africa. The need for mainstreaming and prioritising ID in non-disability related and across impairment programmes is highlighted. We note the importance of families and emphasise the need to draw on informal and traditional forms of care and participation. The need for reliable research evidence to support practice is highlighted. We conclude with a call to action by and on behalf of individuals with ID to be included in the development priorities of the continent. Implications for Rehabilitation Service provision for people with intellectual disabilities in Africa is not always well served by insights obtained from western research agendas. Appropriate and effective rehabilitation requires an understanding of the context and the environment in which the disabled person operates. Indigenous research into the provision of support to families and the inclusion of persons with intellectual disability into mainstream programmes as well as disability specific provision is recommended.

  12. Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research.

    Science.gov (United States)

    Hulme, S Elizabeth; Whitesides, George M

    2011-05-16

    This Review discusses the potential usefulness of the worm Caenorhabditis elegans as a model organism for chemists interested in studying living systems. C. elegans, a 1 mm long roundworm, is a popular model organism in almost all areas of modern biology. The worm has several features that make it attractive for biology: it is small (biology, the Review provides examples of current research with C. elegans that is chemically relevant. It also describes tools-biological, chemical, and physical-that are available to researchers studying the worm. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Innovative quantum technologies for microgravity fundamental physics and biological research

    Science.gov (United States)

    Kierk, I.; Israelsson, U.; Lee, M.

    2001-01-01

    This paper presents a new technology program, within the fundamental physics research program, focusing on four quantum technology areas: quantum atomics, quantum optics, space superconductivity and quantum sensor technology, and quantum fluid based sensor and modeling technology.

  14. 75 FR 6651 - Biological and Environmental Research Advisory Committee

    Science.gov (United States)

    2010-02-10

    ... 24, 2010, 8:30 a.m. to 12 p.m., E.S.T. ADDRESSES: Hilton Hotel, 620 Perry Parkway, Gaithersburg, MD... on the Climate Research Roadmap, BER Grand Challenge Workshop, Complex Systems Science New Business...

  15. Northeast Cooperative Research Study Fleet (SF) Program Biological Sampling Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Northeast Cooperative Research Study Fleet (SF) Program partners with a subset of commercial fishermen to collect high quality, high resolution, haul by haul...

  16. Dermal tumorigen PAH and complex mixtures for biological research

    International Nuclear Information System (INIS)

    Griest, W.H.; Guerin, M.R.; Ho, C.

    1985-01-01

    Thirteen commercially available, commonly reported four-five ring dermal tumorigen PAHs, were determined in a set of complex mixtures consisting of crude and upgraded coal liquids, and petroleum crude oils and their distillate fractions. Semi-preparative scale, normal phase high performance liquid chromatographic fractionation followed by capillary column gas chromatography or gas chromatography-mass spectroscopy were used for the measurements. Deuterated or carbon-14 labeled PAH served as internal standards or allowed recovery corrections. Approaches for the preparation and measurement of radiolabeled PAH were examined to provide chemical probes for biological study. Synthetic routes for production of 14 C labeled dihydrobenzo[a]pyrene and 14 C- or 3 H 10-azabenzo[a]pyrene are being studied to provide tracers for fundamental studies in tracheal transplant and skin penetration systems. (DT)

  17. Geochemical, hydrological, and biological cycling of energy residual. Research plan

    International Nuclear Information System (INIS)

    Wobber, F.J.

    1983-03-01

    Proposed research goals and specific research areas designed to provide a base of fundamental scientific information so that the geochemical, hydrological, and biophysical mechanisms that contribute to the transport and long term fate of energy residuals in natural systems can be understood are described. Energy development and production have resulted in a need for advanced scientific information on the geochemical transformations, transport rates, and potential for bioaccumulation of contaminants in subsurface environments

  18. Exploring Astrobiology: Future and In-Service Teacher Research Experiences

    Science.gov (United States)

    Cola, J.; Williams, L. D.; Snell, T.; Gaucher, E.; Harris, B.; Usselman, M. C.; Millman, R. S.

    2009-12-01

    The Georgia Tech Center for Ribosome Adaptation and Evolution, a center funded by the NASA Astrobiology Institute, developed an educational Astrobiology program titled, “Life on the Edge: Astrobiology.” The purpose of the program was to provide educators with the materials, exposure, and skills necessary to prepare our future workforce and to foster student interest in scientific discovery on Earth and throughout the universe. A one-week, non-residential summer enrichment program for high school students was conducted and tested by two high school educators, an undergraduate student, and faculty in the Schools of Biology, and Chemistry and Biochemistry at Georgia Tech. In an effort to promote and encourage entry into teaching careers, Georgia Tech paired in-service teachers in the Georgia Intern-Fellowship for Teachers (GIFT) program with an undergraduate student interested in becoming a teacher through the Tech to Teaching program. The GIFT and Tech to Teaching fellows investigated extremophiles which have adapted to life under extreme environmental conditions. As a result, extremophiles became the focus of a week-long, “Life on the Edge: Astrobiology” curriculum aligned with the Georgia Performance Standards in Biology. Twenty-five high school students explored the adaptation and survival rates for various types of extremophiles exposed to UV radiation and desiccation; students were also introduced to hands-on activities and techniques such as genomic DNA purification, gel electrophoresis, and Polymerase Chain Reaction (PCR). The impact on everyone invested and involved in the Astrobiology program including the GIFT and Tech to Teaching fellows, high school students, and faculty are discussed.

  19. Mixed-Methods Design in Biology Education Research: Approach and Uses

    Science.gov (United States)

    Warfa, Abdi-Rizak M.

    2016-01-01

    Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both…

  20. Secondary data sources for health services research in urologic oncology.

    Science.gov (United States)

    Cole, Alexander P; Friedlander, David F; Trinh, Quoc-Dien

    2018-04-01

    Though secondary data analyses of large datasets may reduce logistical and financial barriers required to perform significant and innovative work, such research requires specialized skills in data handling and statistical techniques as well as thorough and detailed knowledge of the data sources being used. To provide an overview of several common types of secondary data, focusing on strengths, weaknesses and examples of how these data may be used for health services research. Secondary data comprise a broad and heterogeneous category. This review covers several large categories of such data with examples of their use and discussions about their strengths and weaknesses. Sources include administrative data, claims-based datasets, electronic health records health surveys, patient or disease or both registries, quality improvement initiatives, as well as data from existing trials. Linkages of different types of data may expand the scope of questions answerable using secondary data analysis. Specific strengths and weaknesses of each type of dataset are discussed along with examples from the recent urologic literature. Choice of the appropriate data source should be tailored to the specific research question as well as the research resources and expertise available. Appropriate decisions about which data to use are the foundation for valid, high-impact research using secondary data. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. Service user reflections on the impact of involvement in research.

    Science.gov (United States)

    Gordon, Jim; Franklin, Sue; Eltringham, Sabrina A

    2018-01-01

    Public involvement can impact on research, on the public who give advice, on the researchers and the research participants. Evaluating impact is an important part of the research process. Two members of a hospital-based patient research panel and our coordinator have written this paper. Our panel covers a range of rehabilitation and palliative services. These services form the "Therapeutics and Palliative Care Directorate". We describe how we worked collaboratively with hospital staff and co-produced questionnaires to evaluate the impact of our involvement. We compared the different perspectives of the researchers and panel members on our contribution to the research. We present evidence from these different standpoints, including how our panel made a difference. We found we needed to adapt how we collected the views of the researchers and our members to ensure it was meaningful to our group whilst delivering the wider objective of the hospital. A key finding has been how our involvement has extended into other groups, which has identified opportunities for sharing resources and experience, including areas such as cost effectiveness. Our two-person membership of a high level Board of Academics and Senior Clinicians, which oversees the research we contribute to, has resulted in our opinions influencing the heart of the Directorate's research strategy. We have learned the importance of a flexible approach as the Directorate changes, and the demands on us grow. This will continue to help us share our own development, successes and experience and extend the benefits from working this way. Background Reports about the impact of patient and public involvement in research can be improved by involving patients and research staff more collaboratively to co-produce instruments to measure their involvement. This commentary, written by two members of a hospital-based patient panel and their coordinator for its work, describes how we co-produced instruments to evaluate the

  2. Climate services in the tourism sector - examples and market research

    Science.gov (United States)

    Damm, Andrea; Köberl, Judith; Prettenthaler, Franz; Kortschak, Dominik; Hofer, Marianne; Winkler, Claudia

    2017-04-01

    Tourism is one of the most weather-sensitive sectors. Hence, dealing with weather and climate risks is an important part of operational risk management. WEDDA® (WEather Driven Demand Analysis), developed by Joanneum Research, represents a comprehensive and flexible toolbox for managing weather and climate risks. Modelling the demand for products or services of a particular economic sector or company and its weather and climate sensitivity usually forms the starting and central point of WEDDA®. Coupling the calibrated demand models to either long-term climate scenarios or short-term weather forecasts enables the use of WEDDA® for the following areas of application: (i) implementing short-term forecasting systems for the prediction of the considered indicator; (ii) quantifying the weather risk of a particular economic sector or company using parameters from finance (e.g. Value-at-Risk); (iii) assessing the potential impacts of changing climatic conditions on a particular economic sector or company. WEDDA® for short-term forecasts on the demand for products or services is currently used by various tourism businesses, such as open-air swimming pools, ski areas, and restaurants. It supports tourism and recreation facilities to better cope with (increasing) weather variability by optimizing the disposability of staff, resources and merchandise according to expected demand. Since coping with increasing weather variability forms one of the challenges with respect to climate change, WEDDA® may become an important component within a whole pool of weather and climate services designed to support tourism and recreation facilities to adapt to climate change. Climate change impact assessments at European scale, as conducted in the EU-FP7 project IMPACT2C, provide basic information of climate change impacts on tourism demand not only for individual tourism businesses, but also for regional and national tourism planners and policy makers interested in benchmarks for the

  3. Hospital Supply Expenses: An Important Ingredient in Health Services Research.

    Science.gov (United States)

    Abdulsalam, Yousef; Schneller, Eugene

    2017-07-01

    The purpose of this article is to shed light on hospital supply expenses, which form the second largest expense category after payroll and hold more promise for improving cost-efficiency compared to payroll. However, limited research has rigorously scrutinized this cost category, and it is rarely given specific consideration across cost-focused studies in health services publications. After reviewing previously cited estimates, we examine and independently validate supply expense data (collected by the American Hospital Association) for over 3,500 U.S. hospitals. We find supply expenses to make up 15% of total hospital expenses, on average, but as high as 30% or 40% in hospitals with a high case-mix index, such as surgery-intensive hospitals. Future research can use supply expense data to better understand hospital strategies that aim to manage costs, such as systemization, physician-hospital arrangements, and value-based purchasing.

  4. Pre-Service Science Teachers' Acceptance of Biological Evolution in Turkey

    Science.gov (United States)

    Taskin, Özgür

    2013-01-01

    The present research aims to determine whether or not pre-service science teachers in Turkey are resistant to learning about the theory of evolution (TOE), and to understand the reasons for their acceptance or rejection of this theory. Following an intervention process, essay documents were collected from each participant ("N" = 113) and…

  5. The trajectory of dispersal research in conservation biology. Systematic review.

    Science.gov (United States)

    Driscoll, Don A; Banks, Sam C; Barton, Philip S; Ikin, Karen; Lentini, Pia; Lindenmayer, David B; Smith, Annabel L; Berry, Laurence E; Burns, Emma L; Edworthy, Amanda; Evans, Maldwyn J; Gibson, Rebecca; Heinsohn, Rob; Howland, Brett; Kay, Geoff; Munro, Nicola; Scheele, Ben C; Stirnemann, Ingrid; Stojanovic, Dejan; Sweaney, Nici; Villaseñor, Nélida R; Westgate, Martin J

    2014-01-01

    Dispersal knowledge is essential for conservation management, and demand is growing. But are we accumulating dispersal knowledge at a pace that can meet the demand? To answer this question we tested for changes in dispersal data collection and use over time. Our systematic review of 655 conservation-related publications compared five topics: climate change, habitat restoration, population viability analysis, land planning (systematic conservation planning) and invasive species. We analysed temporal changes in the: (i) questions asked by dispersal-related research; (ii) methods used to study dispersal; (iii) the quality of dispersal data; (iv) extent that dispersal knowledge is lacking, and; (v) likely consequences of limited dispersal knowledge. Research questions have changed little over time; the same problems examined in the 1990s are still being addressed. The most common methods used to study dispersal were occupancy data, expert opinion and modelling, which often provided indirect, low quality information about dispersal. Although use of genetics for estimating dispersal has increased, new ecological and genetic methods for measuring dispersal are not yet widely adopted. Almost half of the papers identified knowledge gaps related to dispersal. Limited dispersal knowledge often made it impossible to discover ecological processes or compromised conservation outcomes. The quality of dispersal data used in climate change research has increased since the 1990s. In comparison, restoration ecology inadequately addresses large-scale process, whilst the gap between knowledge accumulation and growth in applications may be increasing in land planning. To overcome apparent stagnation in collection and use of dispersal knowledge, researchers need to: (i) improve the quality of available data using new approaches; (ii) understand the complementarities of different methods and; (iii) define the value of different kinds of dispersal information for supporting management

  6. The trajectory of dispersal research in conservation biology. Systematic review.

    Directory of Open Access Journals (Sweden)

    Don A Driscoll

    Full Text Available Dispersal knowledge is essential for conservation management, and demand is growing. But are we accumulating dispersal knowledge at a pace that can meet the demand? To answer this question we tested for changes in dispersal data collection and use over time. Our systematic review of 655 conservation-related publications compared five topics: climate change, habitat restoration, population viability analysis, land planning (systematic conservation planning and invasive species. We analysed temporal changes in the: (i questions asked by dispersal-related research; (ii methods used to study dispersal; (iii the quality of dispersal data; (iv extent that dispersal knowledge is lacking, and; (v likely consequences of limited dispersal knowledge. Research questions have changed little over time; the same problems examined in the 1990s are still being addressed. The most common methods used to study dispersal were occupancy data, expert opinion and modelling, which often provided indirect, low quality information about dispersal. Although use of genetics for estimating dispersal has increased, new ecological and genetic methods for measuring dispersal are not yet widely adopted. Almost half of the papers identified knowledge gaps related to dispersal. Limited dispersal knowledge often made it impossible to discover ecological processes or compromised conservation outcomes. The quality of dispersal data used in climate change research has increased since the 1990s. In comparison, restoration ecology inadequately addresses large-scale process, whilst the gap between knowledge accumulation and growth in applications may be increasing in land planning. To overcome apparent stagnation in collection and use of dispersal knowledge, researchers need to: (i improve the quality of available data using new approaches; (ii understand the complementarities of different methods and; (iii define the value of different kinds of dispersal information for supporting

  7. Applying combinatorial chemistry and biology to food research.

    Science.gov (United States)

    Wong, Dominic; Robertson, George

    2004-12-01

    In the past decade combinatorial chemistry has become a major focus of research activity in the pharmaceutical industry for accelerating the development of novel therapeutic compounds. The same combinatorial strategies could be applied to a broad spectrum of areas in agricultural and food research, including food safety and nutrition, development of product ingredients, and processing and conversion of natural products. In contrast to "rational design", the combinatorial approach relies on molecular diversity and high-throughput screening. The capability of exploring the structural and functional limits of a vast population of diverse chemical and biochemical molecules makes it possible to expedite the creation and isolation of compounds of desirable and useful properties. Several studies in recent years have demonstrated the utility of combinatorial methods for food research. These include the discovery of synthetic antimicrobial, antioxidative, and aflatoxin-binding peptides, the identification and analysis of unique flavor compounds, the generation of new enzyme inhibitors, the development of therapeutic antibodies for botulinum neurotoxins, the synthesis of unnatural polyketides and carotenoids, and the modification of food enzymes with novel properties. The results of such activities could open a large area of applications with potential benefits to the food industry. This review describes the current techniques of combinatorial chemistry and their applications, with emphasis on examples in food science research.

  8. Polyhydroyalkanoates: from Basic Research and Molecular Biology to Application

    Directory of Open Access Journals (Sweden)

    Amro Abd alFattah Amara

    2010-09-01

    Full Text Available This review describes the Polyhydroxyalkanoate (PHA, an intracellular biodegradable microbial polymer. PHAs is formed from different types of three hydroxyalkanoic acids monomers, each unit forms an ester bond with the hydroxyl group of the other one and the hydroxyl substituted carbon has R configuration. The C-3 atom in β position is branched with at least one carbon atom in the form of methyl group (C1 to thirteen carbons in the form of tridecyl (C13. This alkyl side chain is not necessarily saturated. PHAs are biosynthesized through regulated pathways by specific enzymes. PHAs are accumulated in bacterial cells from soluble to insoluble form as storage materials inside the inclusion bodies during unbalanced nutrition or to save organisms from reducing equivalents. PHAs are converted again to soluble components by PHAs depolymerases and the degraded materials enter various metabolic pathways. Until now, four classes of enzymes responsible for PHAs polymerization are known. PHAs were well studied regarding their promising applications, physical, chemical and biological properties. PHAs are biodegradable, biocompatible, have good material properties, renewable and can be used in many applications. The most limiting factor in PHAs commercialization is their high cost compared to the petroleum plastics. This review highlights the new knowledge and that established by the pioneers in this field as well as the factors, which affect PHAs commercialization.

  9. Molecular biological change in oral cancer, summary of our researches

    Directory of Open Access Journals (Sweden)

    Nobuharu Yamamoto, DDS, PhD

    2015-02-01

    Full Text Available Molecular biological search and identification of cancer have a variety of clinical significance. Microarray, proteomics and metabolome analyses are powerful analytical methods for rapid screening of tumor markers. From the results, it was revealed that a number of genes are specifically expressed in oral cancers. From the results of CAN and LOH analyses of the entire genome, three candidate gene loci (D1S1189, D1S2151, D1S2595 were identified on 1q31.1 region. From the results obtained by using array CGH, amplification of the 11q13 regions was observed in 30% of the group with lymph node metastasis, and a numbers of genes were located in the 11q13 regions, in which increase of the copy number was observed in only the group with lymph node metastasis. From the results of proteomics analysis, three protein spots, in which expression increased in a common manner with a oral cancer cell line, as well as 27 spots, in which expression decreased in a common manner with a oral cancer cell line, were identified from these cataloged spots. Seven spots of proteins that are specifically expressed in the whole saliva of oral cancer patients before a surgery and not detected from the whole saliva after the surgery or the whole saliva of a healthy subject were selected. In the metabolome analysis, peaks of 250 of the major metabolic substances (136 cations, 114 anions were detected.

  10. Invertebrates as model organisms for research on aging biology.

    Science.gov (United States)

    Murthy, Mahadev; Ram, Jeffrey L

    2015-01-30

    Invertebrate model systems, such as nematodes and fruit flies, have provided valuable information about the genetics and cellular biology involved in aging. However, limitations of these simple, genetically tractable organisms suggest the need for other model systems, some of them invertebrate, to facilitate further advances in the understanding of mechanisms of aging and longevity in mammals, including humans. This paper introduces 10 review articles about the use of invertebrate model systems for the study of aging by authors who participated in an 'NIA-NIH symposium on aging in invertebrate model systems' at the 2013 International Congress for Invertebrate Reproduction and Development. In contrast to the highly derived characteristics of nematodes and fruit flies as members of the superphylum Ecdysozoa, cnidarians, such as Hydra, are more 'basal' organisms that have a greater number of genetic orthologs in common with humans. Moreover, some other new model systems, such as the urochordate Botryllus schlosseri , the tunicate Ciona , and the sea urchins (Echinodermata) are members of the Deuterostomia, the same superphylum that includes all vertebrates, and thus have mechanisms that are likely to be more closely related to those occurring in humans. Additional characteristics of these new model systems, such as the recent development of new molecular and genetic tools and a more similar pattern to humans of regeneration and stem cell function suggest that these new model systems may have unique advantages for the study of mechanisms of aging and longevity.

  11. 2012 Gordon Research Conference on Cellular and Molecular Fungal Biology, Final Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    Berman, Judith [Univ. of Minnesota, Minneapolis, MN (United States)

    2012-06-22

    The Gordon Research Conference on Cellular and Molecular Fungal Biology was held at Holderness School, Holderness New Hampshire, June 17 - 22, 2012. The 2012 Gordon Conference on Cellular and Molecular Fungal Biology (CMFB) will present the latest, cutting-edge research on the exciting and growing field of molecular and cellular aspects of fungal biology. Topics will range from yeast to filamentous fungi, from model systems to economically important organisms, and from saprophytes and commensals to pathogens of plants and animals. The CMFB conference will feature a wide range of topics including systems biology, cell biology and morphogenesis, organismal interactions, genome organisation and regulation, pathogenesis, energy metabolism, biomass production and population genomics. The Conference was well-attended with 136 participants. Gordon Research Conferences does not permit publication of meeting proceedings.

  12. Researcher-library collaborations: Data repositories as a service for researchers.

    Science.gov (United States)

    Gordon, Andrew S; Millman, David S; Steiger, Lisa; Adolph, Karen E; Gilmore, Rick O

    New interest has arisen in organizing, preserving, and sharing the raw materials-the data and metadata-that undergird the published products of research. Library and information scientists have valuable expertise to bring to bear in the effort to create larger, more diverse, and more widely used data repositories. However, for libraries to be maximally successful in providing the research data management and preservation services required of a successful data repository, librarians must work closely with researchers and learn about their data management workflows. Databrary is a data repository that is closely linked to the needs of a specific scholarly community-researchers who use video as a main source of data to study child development and learning. The project's success to date is a result of its focus on community outreach and providing services for scholarly communication, engaging institutional partners, offering services for data curation with the guidance of closely involved information professionals, and the creation of a strong technical infrastructure. Databrary plans to improve its curation tools that allow researchers to deposit their own data, enhance the user-facing feature set, increase integration with library systems, and implement strategies for long-term sustainability.

  13. Public health services and systems research: current state of finance research.

    Science.gov (United States)

    Ingram, Richard C; Bernet, Patrick M; Costich, Julia F

    2012-11-01

    There is a growing recognition that the US public health system should strive for efficiency-that it should determine the optimal ways to utilize limited resources to improve and protect public health. The field of public health finance research is a critical part of efforts to understand the most efficient ways to use resources. This article discusses the current state of public health finance research through a review of public health finance literature, chronicles important lessons learned from public health finance research to date, discusses the challenges faced by those seeking to conduct financial research on the public health system, and discusses the role of public health finance research in relation to the broader endeavor of Public Health Services and Systems Research.

  14. Bibliometric analysis of health services research in otolaryngology journals.

    Science.gov (United States)

    Sun, Gordon H

    2012-11-01

    Determine current health services research (HSR) publication trends in major general otolaryngology journals. Bibliometric analysis. All main issues of 8 high-impact general-interest otolaryngology journals published worldwide in 2002, 2005, 2008, and 2011 were searched for HSR-related publications. To qualify as HSR, the abstract of the article must discuss access to care, cost, delivery of care, financing, health organizational or system issues, quality of care, resource utilization, and/or health outcomes. Otolaryngology topics were classified as general, pediatrics, oncology, otology and neurotology, sleep disorders, sinonasal disease, facial plastics, and/or laryngology. Other key measures included study authorship and external sponsorship or mechanism of support. Of 5958 total articles, 449 (7.5%) qualified as HSR. There was a statistically significant increase in the number of HSR publications across all journals from 2002 to 2011 (P < .001). Outcomes research (337, 75.1%) was the most common type of HSR being published. The most common subject was oncology (112, 24.9%), whereas the least represented was trauma and facial plastics (4, 0.9%). First and corresponding authors were based in 31 countries, although the United States was the predominant country of origin. Nearly 95% of HSR articles in the current sample demonstrated multidisciplinary authorship. An estimated 22.9% of first authors and 17.8% of corresponding authors were female. Two-thirds of HSR publications reported no external sponsor, whereas the remainder was supported most commonly by philanthropy and hospital-based sources. Health services research is an international, multidisciplinary field of inquiry with an increasing presence in major otolaryngology journals.

  15. PERMITTIVITY RESEARCH OF BIOLOGICAL SOLUTIONS IN GIGAHERTZ FREQUENCY RANGE

    Directory of Open Access Journals (Sweden)

    Anton S. Demin

    2017-07-01

    Full Text Available Subject of Research. We present results of permittivity research in gigahertz frequency range for saline and glucose solutions used in medical practice. Experiment results are substantiated theoretically on the basis of Debye-Cole model. Method. Researches have been carried out on blood plasma of healthy donor, water, normal saline and glucose solutions with different concentration from 3 to 12 mmol/l. Experiments have been performed by an active nearfield method based on measuring the impedance of a plane air-liquid boundary with open end of coaxial waveguide in the frequency range from 1 to 12 GHz. Measurement results have been processed with the use of vector analyzer computer system from Rohde & Schwarz. Transmittance spectra have been determined by means of IR-spectrometer from TENZOR-Bruker. Main Results. Simulation results have shown good agreement between the experimental results and the model, as well as the choice of the main parameters of the Debye-Cole model in the studied frequency range for all media. It has been shown that the range of 3-6 GHz can be considered as the main one in the development of diagnostic sensors for the non-invasive analysis of the glucose concentration in the human blood. Practical Relevance. Electrodynamic models of test fluid replacing human blood give the possibility to simulate the sensor basic characteristics for qualitative and quantitative estimation of glucose concentration in human blood and can be used to create an experimental sample of a non- invasive glucometer.

  16. Mixed-Methods Design in Biology Education Research: Approach and Uses

    Science.gov (United States)

    Warfa, Abdi-Rizak M.

    2016-01-01

    Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. PMID:27856556

  17. A Thai pre-service teacher's understanding of nature of science in biology teaching

    Science.gov (United States)

    Srisawat, Akkarawat; Aiemsum-ang, Napapan; Yuenyong, Chokchai

    2018-01-01

    This study was conducted on the effect of understanding and instruction of the nature of science of Ms. Wanida, a pre-service student under science education program in biology, Faculty of Education, Khon Kaen University. Wanida was a teaching practicum student majoring in biology at Khon Kaen University Demonstration School (Modindaeng). She was teaching biology for 38 Grade 10 students. Methodology regarded interpretive paradigm. The study aimed to examine 1) Wanida's understanding of the nature of science, 2) Wanida's instruction of the nature of science, 3 students' understanding of the nature of science from Wanida's instruction, and 4) the effects of Wanida's understanding and instruction of the nature of science on students' understanding of the nature of science from Wanida's instruction. Tools of interpretation included teaching observation, a semi-structured interview, open-ended questionnaire, and an observation record form for the instruction of the nature of science. The data obtained was interpreted, encoded, and classified, using the descriptive statistics. The findings indicated that Wanida held good understanding of the nature of science. She could apply the deficient nature of science approach mostly, followed by the implicit nature of science approach. Unfortunately, she could not show her teaching as explicit nature of science. However, her students' the understanding of the nature of science was good.

  18. Thai in-service teacher understanding of nature of science in biology teaching: Case of Mali

    Science.gov (United States)

    Aiemsum-ang, Napapan; Yuenyong, Chokchai

    2018-01-01

    This paper aimed to investigate the existing ideas of nature of science (NOS) teaching in Thailand biology classroom. The study reported the existing ideas of nature of science (NOS) teaching of one biology teacher Mrs. Mali who had been teaching for 6 years at in a school in Khon Kaen city. Methodology regarded interpretive paradigm. Tools of interpretation included 2 months of classroom observation, interviewing, and questionnaire of NOS. The findings revealed Mali held good understanding of the nature of science in the aspect of the use of evidence, the aspect of knowledge inquiry through different observation and deduction, the aspect of creativity and imagination influencing science knowledge inquiry, and the aspect of changeable scientific knowledge. Her biology teaching indicated that she used both the deficient nature of science approach and the implicit nature of science approach. The implicit nature of science approach was applied mostly in 7 periods and only 2 periods were arranged using the deficient nature of science approach. The paper has implication for professional development and pre-service program on NOS teaching in Thailand.

  19. Research of student satisfaction with service of higher education

    Directory of Open Access Journals (Sweden)

    Janovac Tatjana D.

    2015-01-01

    Full Text Available In the conditions of overall globalization, higher education institutions should develop mechanisms of sustainable development and success in the competitive academic field. Designing a quality management system is the basis for continuous improvement of services, as well as recognition of obligations towards the users and parties in interest. In order to reach its goals, a higher education institution should offer continuously improving values to its users. Understanding , meeting and surpassing the needs and expectations of higher education users is of utmost importance for gaining competitive advantage, positioning in the academic field, sustainable development, and with that, reaching sustainable success. The aim of the research presented in this paper at emphasizing the significance of application of the quality management system model as an efficient tool for providing quality in the educational process, improving higher education service and reaching satisfaction of the users. Such an approach enables the management structure of a higher education institution to have a constant monitoring of the key parameters of its business activities and to make decisions in the field of constant quality improving.

  20. Management of Service Projects in Support of Space Flight Research

    Science.gov (United States)

    Love, J.

    2009-01-01

    Goal:To provide human health and performance countermeasures, knowledge, technologies, and tools to enable safe, reliable, and productive human space exploration . [HRP-47051] Specific Objectives: 1) Develop capabilities, necessary countermeasures, and technologies in support of human space exploration, focusing on mitigating the highest risks to human health and performance. 2) Define and improve human spaceflight medical, environmental, and human factors standards. 3) Develop technologies that serve to reduce medical and environmental risks, to reduce human systems resource requirements (mass, volume, power, data, etc.) and to ensure effective human-system integration across exploration systems. 4) Ensure maintenance of Agency core competencies necessary to enable risk reduction in the following areas: A. Space medicine B. Physiological and behavioral effects of long duration spaceflight on the human body C. Space environmental effects, including radiation, on human health and performance D. Space "human factors" [HRP-47051]. Service projects can form integral parts of research-based project-focused programs to provide specialized functions. Traditional/classic project management methodologies and agile approaches are not mutually exclusive paradigms. Agile strategies can be combined with traditional methods and applied in the management of service projects functioning in changing environments. Creative collaborations afford a mechanism for mitigation of constrained resource limitations.

  1. 76 FR 19189 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2011-04-06

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on April... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation Committee; Notice of Meeting The Department of Veterans Affairs (VA) gives...

  2. 76 FR 65781 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2011-10-24

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation Committee, Notice of Meeting The Department of Veterans Affairs (VA) gives...

  3. 75 FR 79446 - Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2010-12-20

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation Committee; Notice of Meeting The Department of Veterans Affairs (VA) gives...

  4. 76 FR 73781 - Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2011-11-29

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation Committee; Notice of Meeting The Department of Veterans Affairs (VA) gives...

  5. 75 FR 28686 - Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2010-05-21

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on June... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service; Cooperative Studies Scientific Evaluation Committee; Notice of Meeting The Department of Veterans Affairs (VA) gives...

  6. 77 FR 31072 - Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation...

    Science.gov (United States)

    2012-05-24

    ... Research and Development Service Cooperative Studies Scientific Evaluation Committee will be held on July... DEPARTMENT OF VETERANS AFFAIRS Clinical Science Research and Development Service Cooperative Studies Scientific Evaluation Committee; Notice of Meeting The Department of Veterans Affairs (VA) gives...

  7. Data Resources for Conducting Health Services and Policy Research.

    Science.gov (United States)

    Blewett, Lynn A; Call, Kathleen Thiede; Turner, Joanna; Hest, Robert

    2018-04-01

    Rich federal data resources provide essential data inputs for monitoring the health and health care of the US population and are essential for conducting health services policy research. The six household surveys we document in this article cover a broad array of health topics, including health insurance coverage (American Community Survey, Current Population Survey), health conditions and behaviors (National Health Interview Survey, Behavioral Risk Factor Surveillance System), health care utilization and spending (Medical Expenditure Panel Survey), and longitudinal data on public program participation (SIPP). New federal activities are linking federal surveys with administrative data to reduce duplication and response burden. In the private sector, vendors are aggregating data from medical records and claims to enhance our understanding of treatment, quality, and outcomes of medical care. Federal agencies must continue to innovate to meet the continuous challenges of scarce resources, pressures for more granular data, and new multimode data collection methodologies.

  8. The Auger effect in physical and biological research.

    Science.gov (United States)

    Nikjoo, H; Emfietzoglou, D; Charlton, D E

    2008-12-01

    The paper reports on progress in physics of radiationless transitions and new Auger spectra of (125)I and (124)I. We report progress in Monte Carlo track structure simulation of low energy electrons comprising majority electrons released in decay most Auger emitters. The input data for electron capture (EC) and internal conversion(IC) were obtained from various physics data libraries. Monte Carlo technique was used for the simulation of Auger electron spectra. Similarly, electron tracks were generated using Monte Carlo track structure methods. Data are presented for the EC, IC and binding energy (BE) of radionuclides (124)I and (125)I. For each of the radionuclides (125)I and (124)I some examples of electron spectra of individual decays are given. Because most Auger electrons are low energy and short range, data and a short discussion are presented on recent Monte Carlo track structure development in condensed media and their accuracy. Accuracy of electron spectra calculated in the decay of electron shower by Auger emitting radionuclides depends on availability of accurate physics data. There are many gaps in these libraries and there is a need for detailed comparison between analytical method and Monte Carlo calculations to refine the method of calculations. On simulation of electron tracks, although improved models for sub-keV electron interaction cross sections for liquid water are now available, more experimental data are needed for benchmarking. In addition, it is desirable to make data and programs for calculations of Auger spectra available online for use by students and researchers.

  9. Research and engineering assessment of biological solubilization of phosphate

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, R.D.; McIlwain, M.E.; Losinski, S.J.; Taylor, D.D.

    1993-03-01

    This research and engineering assessment examined a microbial phosphate solubilization process as a method of recovering phosphate from phosphorus containing ore compared to the existing wet acid and electric arc methods. A total of 860 microbial isolates, collected from a range of natural environments were tested for their ability to solubilize phosphate from rock phosphate. A bacterium (Pseudomonas cepacia) was selected for extensive characterization and evaluation of the mechanism of phosphate solubilization and of process engineering parameters necessary to recover phosphate from rock phosphate. These studies found that concentration of hydrogen ion and production of organic acids arising from oxidation of the carbon source facilitated microbial solubilization of both pure chemical insoluble phosphate compounds and phosphate rock. Genetic studies found that phosphate solubilization was linked to an enzyme system (glucose dehydrogenase). Process-related studies found that a critical solids density of 1% by weight (ore to liquid) was necessary for optimal solubilization. An engineering analysis evaluated the cost and energy requirements for a 2 million ton per year sized plant, whose size was selected to be comparable to existing wet acid plants.

  10. The value of opinion in science and the Forest Service research organization

    Science.gov (United States)

    Leonard F. Ruggiero

    2009-01-01

    There is confusion about conflicts of interest between sources of funding and the extent to which Forest Service researchers are free to publish their findings. Forest Service Research is an independent entity with no administrative accountability to policy makers up to the office of the Chief of the Forest Service. Congressional mandate ensures that research will be...

  11. Ecology and biology of paddlefish in North America: historical perspectives, management approaches, and research priorities

    Science.gov (United States)

    Jennings, Cecil A.; Zigler, Stephen J.

    2000-01-01

    Paddlefish (Polyodon spathula, Polyodontidae) are large, mostly-riverine fish that once were abundant in medium- to large-sized river systems throughout much of the central United States. Concern for paddlefish populations has grown from a regional fisheries issue to one of national importance for the United States. In 1989, the U.S. Fish and Wildlife Service (USFWS) was petitioned to list paddlefish as a federally threatened species under the Endangered Species Act. The petition was not granted, primarily because of a lack of empirical data on paddlefish population size, age structure, growth, or harvest rates across the present 22-state range. Nonetheless, concern for paddlefish populations prompted the USFWS to recommend that paddlefish be protected through the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). The addition of paddlefish to Appendix II of CITES, which was approved in March 1992, provides a mechanism to curtail illegal trade in paddlefish and their parts and supports a variety of conservation plans. Paddlefish populations have been negatively affected by overharvest, river modifications, and pollution, but the paddlefish still occupies much of its historic range and most extant populations seem to be stable. Although many facets of paddlefish biology and ecology are well understood, the lack of information on larval and juvenile ecology, mechanisms that determine recruitment, population size and vital rates, interjurisdictional movements, and the effects of anthropogenic activities present significant obstacles for managing paddlefish populations. Questions about the size and structure of local populations, and how such populations are affected by navigation traffic, dams, and pollution are regarded as medium priority areas for future research. The availability of suitable spawning habitat and overall reproductive success in impounded rivers are unknown and represent critical areas for future research

  12. SeqHound: biological sequence and structure database as a platform for bioinformatics research

    Directory of Open Access Journals (Sweden)

    Dumontier Michel

    2002-10-01

    Full Text Available Abstract Background SeqHound has been developed as an integrated biological sequence, taxonomy, annotation and 3-D structure database system. It provides a high-performance server platform for bioinformatics research in a locally-hosted environment. Results SeqHound is based on the National Center for Biotechnology Information data model and programming tools. It offers daily updated contents of all Entrez sequence databases in addition to 3-D structural data and information about sequence redundancies, sequence neighbours, taxonomy, complete genomes, functional annotation including Gene Ontology terms and literature links to PubMed. SeqHound is accessible via a web server through a Perl, C or C++ remote API or an optimized local API. It provides functionality necessary to retrieve specialized subsets of sequences, structures and structural domains. Sequences may be retrieved in FASTA, GenBank, ASN.1 and XML formats. Structures are available in ASN.1, XML and PDB formats. Emphasis has been placed on complete genomes, taxonomy, domain and functional annotation as well as 3-D structural functionality in the API, while fielded text indexing functionality remains under development. SeqHound also offers a streamlined WWW interface for simple web-user queries. Conclusions The system has proven useful in several published bioinformatics projects such as the BIND database and offers a cost-effective infrastructure for research. SeqHound will continue to develop and be provided as a service of the Blueprint Initiative at the Samuel Lunenfeld Research Institute. The source code and examples are available under the terms of the GNU public license at the Sourceforge site http://sourceforge.net/projects/slritools/ in the SLRI Toolkit.

  13. Applications of research results from NPAR service water system studies

    International Nuclear Information System (INIS)

    Jarrell, D.B.; Stratton, R.C.

    1991-01-01

    Under the Nuclear Plant Aging Research (NPAR) program, the Nuclear Regulatory Commission (NRC) has invested considerable resources in understanding the mechanisms, mitigating the damage, and managing the results of nuclear power plant aging degradation. Many direct benefits have resulted from this program in terms of improved plant safety through upgraded regulatory guidance. The 'Service Water System (SWS) Aging Degradation Assessment' (NUREG/CR-5379), produced by the Pacific Northwest Laboratory (PNL), contributed to this program. Two other benefits have resulted from the NPAR SWS task: (1) a contribution to the content of Generic Letter 89-13 (nuclear plant SWS performance requirements) and (2) the development of a systematic and complete root-cause analysis (RCA) methodology for use in the solution of SWS as well as other system component failures. Less recognized, but also of significance, are the spin-off initiatives from the NRC's NPAR program investigations. One such spin-off resulting specifically from the NRC-sponsored SWS research is the continuing development of the RCA methodology to facilitate the computerized integration of the following: (1) component condition monitoring; (2) fault diagnostics; and (3) failure root cause analysis. The Decision Support system for Operations and Maintenance project being developed at PNL is implementing the NPAR-developed RCA methodology utilizing an artificial intelligence approach

  14. Nucleic Acids Research annual Database Issue and the NAR online Molecular Biology Database Collection in 2009.

    Science.gov (United States)

    Galperin, Michael Y; Cochrane, Guy R

    2009-01-01

    The current issue of Nucleic Acids Research includes descriptions of 179 databases, of which 95 are new. These databases (along with several molecular biology databases described in other journals) have been included in the Nucleic Acids Research online Molecular Biology Database Collection, bringing the total number of databases in the collection to 1170. In this introductory comment, we briefly describe some of these new databases and review the principles guiding the selection of databases for inclusion in the Nucleic Acids Research annual Database Issue and the Nucleic Acids Research online Molecular Biology Database Collection. The complete database list and summaries are available online at the Nucleic Acids Research web site (http://nar.oxfordjournals.org/).

  15. Biological research on burnout-depression overlap: Long-standing limitations and on-going reflections.

    Science.gov (United States)

    Bianchi, Renzo; Schonfeld, Irvin Sam; Laurent, Eric

    2017-12-01

    In this commentary, we discuss seldom-noticed methodological problems affecting biological research on burnout and depression and make recommendations to overcome the limitations of past studies conducted in this area. First, we suggest that identified subtypes of depression (e.g., depression with melancholic features and depression with atypical features) should be taken into account in future biological research on burnout and depression, given that different subtypes of depression have been associated with distinct autonomic and neuroendocrine profiles. Second, we underline that research on burnout-depression overlap is made difficult by the absence of a consensual conceptualization and operationalization of burnout. In order to resolve this problem, we draw researchers' attention to the urgency of establishing a commonly shared, clinically valid diagnosis for burnout. Finally, we question the possibility of identifying a biological signature for burnout in light of global research on burnout-depression overlap. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Research on new information service model of the contemporary library

    International Nuclear Information System (INIS)

    Xin Pingping; Lu Yan

    2010-01-01

    According to the development of the internet and multimedia technology, the information service models in the contemporary library become both of the traditional and digital information service. The libraries in each country do their best to make the voluminous information and the complex technology be High-integrated in the background management, and also make the front interface be more and more convenient to the users. The essential characteristics of the information service of the contemporary library are all-in-one and humanness. In this article, we will describe several new hot information service models of the contemporary library in detail, such as individualized service, reference service, reference service and strategic information service. (authors)

  17. Cost Savings from Volunteer Services: A Research Note.

    Science.gov (United States)

    Lucas, Wayne L.

    1988-01-01

    Assessed amount of cost-saving represented by the use of volunteer services within a probation and parole agency for a 12-month period. Results indicated that volunteer services represented cost savings in excess of $145,000 for the year, and that these services represent an average of 6.33 full time employees (FTEs) per month. (Author)

  18. Europlanet - Joining the European Planetary Research Information Service

    Science.gov (United States)

    Capria, M. T.; Chanteur, G.; Schmidt, W.

    2009-04-01

    The "Europlanet Research Infrastructure - Europlanet RI", supported by the European Commission's Framework Program 7, aims at integrating major parts of the distributed European Planetary Research infrastructure with as diverse components as space exploration, ground-based observations, laboratory experiments and numerical model-ling teams. A central part of Europlanet RI is the "Integrated and Distributed Information Service" or Europlanet-IDIS which intends to provide easy Web-based access to information about scientists and teams working in related fields, observatories or laboratories with capabilities possibly beneficial to planetary research, modelling expertise useful for planetary science and observations from space-based, ground-based or laboratory measurements. As far as the type of data and their access methods allow, IDIS will provide Virtual Observatory (VO) like access to a variety of data from distributed sources and tools to compare and integrate this information to further data analysis and re-search. IDIS itself is providing a platform for information and data sharing and for data mining. It is structured as a network of thematic nodes each concentrating on a sub-set of research areas in planetary sciences. But the most important elements of IDIS and the whole Europlanet RI are the single scientists, institutes, laboratories, observatories and mission project teams. Without them the whole effort would remain an empty shell. How can an interested individual or team join this activity and what are the benefits to be expected from the related effort? The poster gives detailed answers to these questions. Here some highlights: 1. Locate from the Europlanet web pages (addresses see below) the thematic node best related to the own field of expertise. This might be more than one. 2. Define which services you want to offer to the community: just the contact address, field of competence, off-line access to data on request or even on-line searchable access

  19. The application of biological motion research: biometrics, sport, and the military.

    Science.gov (United States)

    Steel, Kylie; Ellem, Eathan; Baxter, David

    2015-02-01

    The body of research that examines the perception of biological motion is extensive and explores the factors that are perceived from biological motion and how this information is processed. This research demonstrates that individuals are able to use relative (temporal and spatial) information from a person's movement to recognize factors, including gender, age, deception, emotion, intention, and action. The research also demonstrates that movement presents idiosyncratic properties that allow individual discrimination, thus providing the basis for significant exploration in the domain of biometrics and social signal processing. Medical forensics, safety garments, and victim selection domains also have provided a history of research on the perception of biological motion applications; however, a number of additional domains present opportunities for application that have not been explored in depth. Therefore, the purpose of this paper is to present an overview of the current applications of biological motion-based research and to propose a number of areas where biological motion research, specific to recognition, could be applied in the future.

  20. The British Services Dhaulagiri Medical Research Expedition 2016: a unique military and civilian research collaboration.

    Science.gov (United States)

    Mellor, Adrian; Bakker-Dyos, J; Howard, M; Boos, C; Cooke, M; Vincent, E; Scott, P; O'Hara, J; Clarke, S B; Barlow, M; Matu, J; Deighton, K; Hill, N; Newman, C; Cruttenden, R; Holdsworth, D; Woods, D

    2017-12-01

    High-altitude environments lead to a significant physiological challenge and disease processes which can be life threatening; operational effectiveness at high altitude can be severely compromised. The UK military research is investigating ways of mitigating the physiological effects of high altitude. The British Service Dhaulagiri Research Expedition took place from March to May 2016, and the military personnel were invited to consent to a variety of study protocols investigating adaptation to high altitudes and diagnosis of high-altitude illness. The studies took place in remote and austere environments at altitudes of up to 7500 m. This paper gives an overview of the individual research protocols investigated, the execution of the expedition and the challenges involved. 129 servicemen and women were involved at altitudes of up to 7500 m; 8 research protocols were investigated. The outputs from these studies will help to individualise the acclimatisation process and inform strategies for pre-acclimatisation should troops ever need to deploy at high altitude at short notice. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  1. The establishment of research ethics consultation services (RECS): an emerging research resource.

    Science.gov (United States)

    McCormick, Jennifer B; Sharp, Richard R; Ottenberg, Abigale L; Reider, Carson R; Taylor, Holly A; Wilfond, Benjamin S

    2013-02-01

    Emphasis on translational research to facilitate progression from the laboratory into the community also creates a dynamic in which ethics and social policy questions and solutions are ever pressing. In response, academic institutions are creating Research Ethics Consultation Services (RECS). All Clinical Translational Science Award institutions were surveyed in early 2010 to determine which institutions have a RECS in operation and what is their composition and function. Of the 46 institutions surveyed, 33 (70%) have a RECS. Only 15 RECS have received any consult requests in the last year. Issues that are common among these relatively nascent services include relationships with institutional oversight committees, balancing requestor concerns about confidentiality with research integrity and human subjects protection priorities, tracking consult data and outcomes, and developing systems for internal evaluation. There is variability in how these issues are approached. It will be important to be attentive to the institutional context to develop an appropriate approach. Further data about the issues raised by requestors and the recommendations provided are necessary to build a community of scholars who can navigate and resolve ethical issues encountered along the translational research pathway. © 2012 Wiley Periodicals, Inc.

  2. Beyond Assessment: Conducting Theoretically Grounded Research on Service-Learning in Gerontology Courses.

    Science.gov (United States)

    Kruger, Tina M; Pearl, Andrew J

    2016-01-01

    Service-learning is a useful pedagogical tool and high-impact practice, providing multiple benefits. Gerontology (and other) courses frequently include service-learning activities but lack theory-based, intentional research on outcomes. Here, the authors define service-learning and contextualize it in higher education, provide an overview of research and assessment in service-learning and gerontology courses, demonstrate the shortcomings of program evaluations, and offer suggestions for future research to advance and generate theory.

  3. RESEARCH REGARDING THE PURCHASE CONSUMER BEHAVIOR OF TOURISM SERVICES

    Directory of Open Access Journals (Sweden)

    Simona Cristina Martin

    2014-05-01

    Full Text Available The service represents nonmaterial solution in solving consumer problems. From this kind of approach arise most features of product policy in provision of services filed. Service is always defined according witch to the needs and requirements of specific groups of consumers, respectively any offer of services witch targets well defined consumer segments, previously established. Per passing day tourism has an increasingly important role in the economy, reason for witch it should be given an special importance of tourism services, which must be analyzed through general features, especially specific ones, to their typology, because, according to these aspects, tourism service providers can provide tourist services that satisfies, at a higher level, consumption needs of the population.

  4. Managing postgraduate research service quality: Developing and assessing a conceptual model

    Directory of Open Access Journals (Sweden)

    Shawn Ramroop

    2013-05-01

    Full Text Available This paper reports on the conceptual development and empirical evaluation of a postgraduate (PG research service quality management model, through conducting an electronic survey among a cohort of master’s and doctorate graduates at one of the top three research universities in South Africa, using specifically developed and validated research instruments.By fitting the data from a sample of 117 graduates to a conceptual model using structural equation modelling, it became evident that the PG research students’ perception of the Organisational Climate for Research (OCR is associated with their perception of the PG Research Service Quality (PGSQUAL, the PG Service Experience (SERVEXP and their perception of their Role (RC. However, no association was found between the students’ perception of the research climate (OCR and their satisfaction (SERVSAT with the research service; the service experience (SERVEXP and postgraduate research service quality (PGSQUAL; service satisfaction (SERVSAT and postgraduate service quality (PGSQUAL.  The aforementioned findings imply that higher education institutions need to create a research climate which is supportive of service quality, and better manage the research climate, so that the PG students are clear about their role, which will eventually translate to a better PG service experience and improved perception of PG service quality.

  5. Chemical, biological, radiological and nuclear preparedness training for emergency medical services provider.

    Science.gov (United States)

    Kollek, Daniel; Wanger, Karen; Welsford, Michelle

    2009-07-01

    We assessed the self-reported theoretical and practical preparedness training of Canadian emergency medical services (EMS) providers in chemical, biological, radiological and nuclear (CBRN) events. We designed an online survey to address the theoretical and practical CBRN training level of prehospital providers. Emergency medical services staff in British Columbia and Ontario were invited to participate. Of the 1028 respondents, 75% were male, and the largest demographic groups were front-line personnel with more than 15 years of experience. Only 63% of respondents indicated they had received either theoretical or practical training to work in a contaminated environment, leaving 37% who indicated they had received neither type of training. Of those that had received any training, 61% indicated they had received "hands-on" or practical training and 82% indicated they had received some training in identification of a possibly contaminated scene. Only 42% had received training for symptoms of nerve agents, 37% had received training for symptoms of blister agents and 46% had received training for symptoms of asphyxiants. Thirty-two percent had received training for the treatment of patients exposed to nerve agents, and 30% had received training for the treatment of patients exposed to blister agents. Only 31% of all respondents had received training for detecting radiation. CBRN events involve unique hazards and require specific education and training for EMS providers. A large proportion of Canadian EMS providers report not having received the training to identify and work in contaminated environments.

  6. A selected review of recent biological psychiatric research in China (translated version).

    Science.gov (United States)

    Fu, Y; Hu, S H; Lam, L C W

    2010-03-01

    This review highlights significant biological psychiatric research published by Chinese researchers in recent years. Chinese periodicals with full-text database (Chinese National Knowledge Infrastructure) and English periodicals with PubMed, published from 2003 to 2009 on schizophrenia, depression, bipolar affective disorder, obsessive-compulsive disorder, anxiety disorder and Alzheimer's disease, were reviewed. Articles studying the above-mentioned psychiatric disorders focusing in the area of molecular genetics, neuroendocrine immunology, electrophysiology and psychopharmacology applied to animal models or clinical populations were included. The findings suggest that biological psychiatric research is being developed at a rapid pace and covers a wide perspective from disease mechanisms to clinical interventions.

  7. 2012 Gordon Research Conference, Plant molecular biology, July 15-20 2012

    Energy Technology Data Exchange (ETDEWEB)

    Sussman, Michael R. [Univ. of Wisconsin, Madison, WI (United States)

    2013-07-20

    The 2012 Gordon Conference on Plant Molecular Biology will present cutting-edge research on molecular aspects of plant growth and development, with particular emphasis on recent discoveries in molecular mechanisms involved with plant signaling systems. The Conference will feature a wide range of topics in plant molecular biology including hormone receptors and early events in hormone signaling, plant perception of and response to plant pathogen and symbionts, as well as technological and biological aspects of epigenomics particularly as it relates to signaling systems that regulate plant growth and development. Genomic approaches to plant signaling will be emphasized, including genomic profiling technologies for quantifying various biological subsystems, such as the epigenome, transcriptome, phosphorylome, and metabolome. The meeting will include an important session devoted to answering the question, "What are the biological and technological limits of plant breeding/genetics, and how can they be solved"?

  8. Highly Adaptable but Not Invulnerable: Necessary and Facilitating Conditions for Research in Evolutionary Developmental Biology

    NARCIS (Netherlands)

    Laudel, Grit; Benninghoff, Martin; Lettkemann, Eric; Håkansson, Elias; Whitley, Richard; Gläser, Jochen

    2014-01-01

    Evolutionary developmental biology is a highly variable scientific innovation because researchers can adapt their involvement in the innovation to the opportunities provided by their environment. On the basis of comparative case studies in four countries, we link epistemic properties of research

  9. Team Research at the Biology-Mathematics Interface: Project Management Perspectives

    Science.gov (United States)

    Milton, John G.; Radunskaya, Ami E.; Lee, Arthur H.; de Pillis, Lisette G.; Bartlett, Diana F.

    2010-01-01

    The success of interdisciplinary research teams depends largely upon skills related to team performance. We evaluated student and team performance for undergraduate biology and mathematics students who participated in summer research projects conducted in off-campus laboratories. The student teams were composed of a student with a mathematics…

  10. Global foot-and-mouth disease research update and gap analysis: 7 - pathogenesis and molecular biology

    Science.gov (United States)

    In 2014, the GFRA (Global Foot-and-mouth disease Research Alliance) conducted a gap analysis of FMD (Foot-and-Mouth Disease) research. This work has been updated and reported in a series of papers, in this article we report findings in the fields of 1) pathogenesis and 2) molecular biology. The arti...

  11. Objectives of research activities in Biology Branch, Chalk River Nuclear Laboratories, 1976

    International Nuclear Information System (INIS)

    1977-03-01

    The primary responsibility assigned to the Biology Branch within the framework of CRNL has been an active engagement in basic research related to the assessment of radiation hazards, particularly those to be expected after exposure to relatively low doses of radiation delivered at low dose-rates. The present group is characterized by a broad interest in the entire chain of events by which the initial radiation-induced changes in the living cell are translated into biological effects, with a special focus of attention on the mechanisms by which the initial damage can be largely repaired and by which the risks to man are modified under different circumstances. The basic concepts in radiation biology and risk estimates are reviewed in the light of recent literature on these topics. The current and proposed research activities of the Biology Branch are described. General and specific recommendations for future activities are given. (author)

  12. At the service of cutting-edge research

    CERN Multimedia

    ISS Magazine

    2012-01-01

    Many external companies work for CERN, including ISS, a market leader in the area of service provision. In an article, republished in full below, due to appear in the next edition of the ISS Magazine, the company puts CERN in the spotlight. Take a moment to discover how an external company sees CERN.   CERN is a world-renowned research facility. ISS, with its 100-strong workforce ensures that the scientists can concentrate 100% on science. Since 1954, scientists from all corners of the globe have been seeking out the origins of the Universe at CERN, the European Laboratory for Particle Physics. CERN has been responsible for ground-breaking discoveries and inventions, such as the Worldwide Web in 1989. The task entrusted to ISS by CERN is as unusual as the laboratory is extraordinary. What started as a simple window-cleaning contract in 1967 has now evolved into a complex logistics operation. Keeping storage costs low For the past 25 years, ISS have been organising CERN's stores management...

  13. Saberes docentes em formação: a pesquisa e a prática de ensino nas licenciaturas em Ciências Biológicas e História Building up teachers' knowledge: the research and teaching practice in pre-service Biology and History teacher education

    Directory of Open Access Journals (Sweden)

    Sandra Escovedo Selles

    2013-04-01

    Full Text Available O artigo está estruturado em torno de três categorias - o conhecimento, as práticas docentes e as razões da escola - que orientam a exploração de relatórios de licenciandos de Ciências Biológicas e de História no contexto das Práticas de Ensino. As demandas dos licenciandos em torno da compreensão acerca das diferenças do conhecimento acadêmico, quando comparado ao conhecimento escolar, são discutidas. O artigo focaliza ainda as práticas docentes, na perspectiva dos licenciandos, evidenciando tanto suas tentativas de compreendê-las quanto sua rejeição aos motivos e aos métodos empregados pelos professores da escola. Por fim, trata das expectativas dos licenciandos sobre a escola, do esforço necessário para compreendê-la, a despeito de uma perspectiva detratora da realidade escolar.The article is organized into three categories - knowledge, teaching practices and school reasons - which guide the analysis of the reports produced by future Biology and History teachers in the context of their pre-service education. The needs of the future teachers related to their understanding about the differences between academic knowledge and school knowledge are discussed. The article also focuses on teaching practices under the perceptions and efforts of the future teachers not only when they try to understand these practices but also when they reject teachers' motives and methods employed by them at school. At last, the article addresses future teachers' expectations related to the school and the necessary efforts to understand it, despite the negative perspective of the school context.

  14. Evolutionary epistemology: Reviewing and reviving with new data the research programme for distributed biological intelligence.

    Science.gov (United States)

    Slijepcevic, Predrag

    2018-01-01

    Numerous studies in microbiology, eukaryotic cell biology, plant biology, biomimetics, synthetic biology, and philosophy of science appear to support the principles of the epistemological theory inspired by evolution, also known as "Evolutionary Epistemology", or EE. However, that none of the studies acknowledged EE suggests that its principles have not been formulated with sufficient clarity and depth to resonate with the interests of the empirical research community. In this paper I review evidence in favor of EE, and also reformulate EE principles to better inform future research. The revamped programme may be tentatively called Research Programme for Distributed Biological Intelligence. Intelligence I define as the capacity of organisms to gain information about their environment, process that information internally, and translate it into phenotypic forms. This multistage progression may be expressed through the acronym IGPT (information-gain-process-translate). The key principles of the programme may be summarized as follows. (i) Intelligence, a universal biological phenomenon promoting individual fitness, is required for effective organism-environment interactions. Given that animals represent less than 0.01% of the planetary biomass, neural intelligence is not the evolutionary norm. (ii) The basic unit of intelligence is a single cell prokaryote. All other forms of intelligence are derived. (iii) Intelligence is hierarchical. It ranges from bacteria to the biosphere or Gaia. (iv) The concept of "information" acquires a new meaning because information processing is at the heart of biological intelligence. All biological systems, from bacteria to Gaia, are intelligent, open thermodynamic systems that exchange information, matter and energy with the environment. (v) The organism-environment interaction is cybernetic. As much as the organism changes due to the influence of the environment, the organism's responses to induced changes affect the environment and

  15. Access and preservation of digital research content: Linked open data services - A research library perspective

    Science.gov (United States)

    Kraft, Angelina; Sens, Irina; Löwe, Peter; Dreyer, Britta

    2016-04-01

    Globally resolvable, persistent digital identifiers have become an essential tool to enable unambiguous links between published research results and their underlying digital resources. In addition, this unambiguous identification allows citation. In an ideal research world, any scientific content should be citable and the coherent content, as well as the citation itself, should be persistent. However, today's scientists do not just produce traditional research papers - they produce comprehensive digital collections of objects which, alongside digital texts, include digital resources such as research data, audiovisual media, digital lab journals, images, statistics and software code. Researchers start to look for services which allow management of these digital resources with minimum time investment. In light of this, we show how the German National Library of Science and Technology (TIB) develops supportive frameworks to accompany the life cycle of scientific knowledge generation and transfer. This includes technical infrastructures for • indexing, cataloguing, digital preservation, DOI names and licencing for text and digital objects (the TIB DOI registration, active since 2004) and • a digital repository for the deposition and provision of accessible, traceable and citeable research data (RADAR). One particular problem for the management of data originating from (collaborating) research infrastructures is their dynamic nature in terms of growth, access rights and quality. On a global scale, systems for access and preservation are in place for the big data domains (e.g. environmental sciences, space, climate). However, the stewardship for disciplines without a tradition of data sharing, including the fields of the so-called long tail, remains uncertain. The RADAR - Research Data Repository - project establishes a generic end-point data repository, which can be used in a collaborative way. RADAR enables clients to upload, edit, structure and describe their

  16. Research on the Hotel Image Based on the Detail Service

    Science.gov (United States)

    Li, Ban; Shenghua, Zheng; He, Yi

    Detail service management, initially developed as marketing programs to enhance customer loyalty, has now become an important part of customer relation strategy. This paper analyzes the critical factors of detail service and its influence on the hotel image. We establish the theoretical model of influencing factors on hotel image and propose corresponding hypotheses. We use applying statistical method to test and verify the above-mentioned hypotheses. This paper provides a foundation for further study of detail service design and planning issues.

  17. The research of the availability at cloud service systems

    Science.gov (United States)

    Demydov, Ivan; Klymash, Mykhailo; Kharkhalis, Zenoviy; Strykhaliuk, Bohdan; Komada, Paweł; Shedreyeva, Indira; Targeusizova, Aliya; Iskakova, Aigul

    2017-08-01

    This paper is devoted to the numerical investigation of the availability at cloud service systems. In this paper criteria and constraints calculations were performed and obtained results were analyzed for synthesis purposes of distributed service platforms based on the cloud service-oriented architecture such as availability and system performance index variations by defined set of the main parameters. The method of synthesis has been numerically generalized considering the type of service workload in statistical form by Hurst parameter application for each integrated service that requires implementation within the service delivery platform, which is synthesized by structural matching of virtual machines using combination of elementary servicing components up to functionality into a best-of-breed solution. As a result of restrictions from Amdahl's Law the necessity of cloud-networks clustering was shown, which makes it possible to break the complex dynamic network into separate segments that simplifies access to the resources of virtual machines and, in general, to the "clouds" and respectively simplifies complex topological structure, enhancing the overall system performance. In overall, proposed approaches and obtained results numerically justifying and algorithmically describing the process of structural and functional synthesis of efficient distributed service platforms, which under process of their configuring and exploitation provides an opportunity to act on the dynamic environment in terms of comprehensive services range and nomadic users' workload pulsing.

  18. Biology

    Indian Academy of Sciences (India)

    I am particularly happy that the Academy is bringing out this document by Professor M S. Valiathan on Ayurvedic Biology. It is an effort to place before the scientific community, especially that of India, the unique scientific opportunities that arise out of viewing Ayurveda from the perspective of contemporary science, its tools ...

  19. Practicing biology: Undergraduate laboratory research, persistence in science, and the impact of self-efficacy beliefs

    Science.gov (United States)

    Berkes, Elizabeth

    As undergraduate laboratory research internships become more popular and universities devote considerable resources towards promoting them, it is important to clarify what students specifically gain through involvement in these experiences and it is important to understand their impact on the science pipeline. By examining recent findings describing the primary benefits of undergraduate research participation, along with self-efficacy theory, this study aims to provide more explanatory power to the anecdotal and descriptive accounts regarding the relationship between undergraduate research experiences and interest in continuing in science. Furthermore, this study characterizes practices that foster students' confidence in doing scientific work with detailed description and analysis of the interactions of researchers in a laboratory. Phase 1 of the study, a survey of undergraduate biology majors (n=71) at a major research university, investigates the relationships among participation in biology laboratory research internships, biology laboratory self-efficacy strength, and interest in persisting in science. Phase 2 of the study, a two-year investigation of a university biology research laboratory, investigates how scientific communities of practice develop self-efficacy beliefs. The findings suggest that participation in lab internships results in increased interest in continuing in life science/biology graduate school and careers. They also suggest that a significant proportion of that interest is related to the students' biology laboratory self-efficacy. The findings of this study point to two primary ways that undergraduate research participation might work to raise self-efficacy strength. First, university research laboratory communities can provide students with a variety of resources that scaffold them into biology laboratory mastery experiences. Second, university research laboratory communities can provide students with coping and mastery Discourse models

  20. Growth Disparity between Medical Research and Medical Services ...

    Indian Academy of Sciences (India)

    Research Institutions started in late 19th and early 20th century included Plague laboratory, Nutrition Research Lab at Coonoor; Malaria Research Institute in Delhi; King Institute, Guindy; Central Research Institute, Kasauli; AIIH & PH at Kolkata.

  1. CASE STUDY: Uzbekistan — Competition research improves services

    International Development Research Centre (IDRC) Digital Library (Canada)

    The goal of the study was to identify anticompetitive activities and restrictive business practices in international money transfer services and find ways to ... At the time the study was conducted, the postal service had recently introduced an automated system for electronic money transfers within the country, but offered limited ...

  2. Internet Use for Service Provision and Research in Libraries and ...

    African Journals Online (AJOL)

    This study discussed internet, the services and the uses, it can be put to in the provision of library services, or in an information centre. Literature search was used to elicit information for this study. The results revealed that whenever internet intervenes in library operations, these is bridge in time, space, minimized cost and ...

  3. International Service Learning: Analytical Review of Published Research Literature

    Science.gov (United States)

    Dixon, Brett

    2015-01-01

    International service learning (ISL) is an emerging area of international education. This paper summarizes academic journal articles on ISL programs and organizes the relevant publications by academic disciplines, service learning project areas, and other topics. The basis for this review is relevant literature from full-text scholarly peer…

  4. Insights into Library Services and Users from Qualitative Research.

    Science.gov (United States)

    Lincoln, Yvonna S.

    2002-01-01

    Describes a study that used interview data to adapt SERVQUAL, a survey to determine customer perceptions of service quality, to LibQUAL[TM], a Web-based survey to investigate users' perceptions of library service quality. Offers hypotheses regarding how data was categorized as it was. (Author/LRW)

  5. The role of evolutionary biology in research and control of liver flukes in Southeast Asia.

    Science.gov (United States)

    Echaubard, Pierre; Sripa, Banchob; Mallory, Frank F; Wilcox, Bruce A

    2016-09-01

    Stimulated largely by the availability of new technology, biomedical research at the molecular-level and chemical-based control approaches arguably dominate the field of infectious diseases. Along with this, the proximate view of disease etiology predominates to the exclusion of the ultimate, evolutionary biology-based, causation perspective. Yet, historically and up to today, research in evolutionary biology has provided much of the foundation for understanding the mechanisms underlying disease transmission dynamics, virulence, and the design of effective integrated control strategies. Here we review the state of knowledge regarding the biology of Asian liver Fluke-host relationship, parasitology, phylodynamics, drug-based interventions and liver Fluke-related cancer etiology from an evolutionary biology perspective. We consider how evolutionary principles, mechanisms and research methods could help refine our understanding of clinical disease associated with infection by Liver Flukes as well as their transmission dynamics. We identify a series of questions for an evolutionary biology research agenda for the liver Fluke that should contribute to an increased understanding of liver Fluke-associated diseases. Finally, we describe an integrative evolutionary medicine approach to liver Fluke prevention and control highlighting the need to better contextualize interventions within a broader human health and sustainable development framework. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Managing the Hotels Service Products and E-Services. Case Study: Researching Tourists’ Satisfaction Regarding the Hotels Services in Romania

    OpenAIRE

    Andreea MARIN-PANTELESCU; Laura Cristina MANIU

    2012-01-01

    The objective of a hospitality business is to provide guests with a place where they feel welcome and appreciated, and where they can relax and have an enjoyable experience. Service is what an establishment does to and for its guests to achieve this objective. Service is not about smiling and servility. It is a strategy that considers the customer while serving the interests of the hotel. Service excellence gives an organization a competitive edge. Outstanding service makes a lot of money for...

  7. Moving from Intersection to Integration: Public Health Law Research and Public Health Systems and Services Research

    Science.gov (United States)

    Burris, Scott; Mays, Glen P; Douglas Scutchfield, F; Ibrahim, Jennifer K

    2012-01-01

    Context For three decades, experts have been stressing the importance of law to the effective operation of public health systems. Most recently, in a 2011 report, the Institute of Medicine recommended a review of state and local public health laws to ensure appropriate authority for public health agencies; adequate access to legal counsel for public health agencies; evaluations of the health effects and costs associated with legislation, regulations, and policies; and enhancement of research methods to assess the strength of evidence regarding the health effects of public policies. These recommendations, and the continued interest in law as a determinant of health system performance, speak to the need for integrating the emerging fields of Public Health Law Research (PHLR) and Public Health Systems and Services Research (PHSSR). Methods Expert commentary. Findings This article sets out a unified framework for the two fields and a shared research agenda built around three broad inquiries: (1) the structural role of law in shaping the organization, powers, prerogatives, duties, and limitations of public health agencies and thereby their functioning and ultimately their impact on public health (“infrastructure”); (2) the mechanisms through which public health system characteristics influence the implementation of interventional public health laws (“implementation”); and (3) the individual and system characteristics that influence the ability of public health systems and their community partners to develop and secure enactment of legal initiatives to advance public health (“innovation”). Research to date has laid a foundation of evidence, but progress requires better and more accessible data, a new generation of researchers comfortable in both law and health research, and more rigorous methods. Conclusions The routine integration of law as a salient factor in broader PHSSR studies of public health system functioning and health outcomes will enhance the

  8. A research on semantic Web services discovery mechanism

    Science.gov (United States)

    Chen, Zhijun; Li, Xinke

    2011-12-01

    Semantic Web service discovery is focused on finding the best services from the majority of services which provide similar or same functions based on Semantic matching Algorithms. This paper firstly proposed a new QoS model for describing Semantic Web services by adding a new significant characteristic (SU ratio) of QoS. To raise the finding work efficiency, we then give an improved algorithm for matching semantic web services; the new algorithm does not only focus on the inclusion relation of ontology concepts in taxonomic tree as implemented by classic algorithms, but also includes binary relations. Through the comparison of weighted semantic distance in taxonomic tree, the similarity computation is more accuracy and the precision ratio and recall ratio of algorithm is enhanced. Finally a preliminary case study was accomplished in order to prove its applicability and viability.

  9. Application of the System Approach to Financial Services Market Research

    Directory of Open Access Journals (Sweden)

    Dubyna Maksym V

    2016-08-01

    Full Text Available The article analyzes the nature of the financial services market by using the system approach methodology. In particular, the attention is focused on the already existing conceptual approaches to defining the nature of this market, their basic aspects are analyzed. The use of the system approach allowed to identify the essence of the financial services market as a single, complex system, which is proposed to be considered as an aggregate number of consumers and providers of financial services operating within a single economic space, their relationships emerging to meet different in their nature demands for financial services, with their interrelation being associated with movement of financial resources within this space and partially accompanied by processes of transformation of temporary free funds of economic entities into credit and investment resources. In the article the system components and the relationships between them are determined, the elements of the environment are identified and their relationship with the market for financial services described.

  10. ANALYSIS OF CK (CONTENT KNOWLEDGE OF PRE-SERVICE BIOLOGY TEACHERS ON CONCEPT OF GENETICS AND ECOLOGY

    Directory of Open Access Journals (Sweden)

    Mega Elvianasti

    2018-01-01

    Full Text Available Content Knowledge (CK is an ability to reveal  a particular object based on the characteristics possessed by the object. The purpose of this research was to analyze the ability of Content Knowledge (CK of Pre-service Biology Teachers  to be viewed based on concept comprehension test. The study used qualitative methods, measured by giving a test in the form of a description of the genetics and ecology, the questions were compiled based on Bloom's taxonomy Revision from C2-C4 level. The research show that; in general prospective teachers have low mastery on the concept of gene regulation, Mendel's Law, and protein synthesis, but they have a good concepts on comprehension of Genes, DNA, and chromosomes, mutations, DNA relations, RNA, polypeptides, transcription and translation in the function of the formation of the nature of living things, and the relationship between sexual reproduction and gene inheritance. For the concept of ecology, in general they have a low mastery on the concept of interaction between organisms, biomass, community of organisms and global changes. While they have a good mastery on concept of the food chain system and the flow of energy, and the population.

  11. Research data services in academic libraries: Data intensive roles for the future?

    Science.gov (United States)

    Tenopir, Carol; Hughes, Dane; Allard, Suzie; Frame, Mike; Birch, Ben; Sandusky, Robert; Langseth, Madison L.; Lundeen, Andrew

    2015-01-01

    Objectives: The primary objectives of this study are to gauge the various levels of Research Data Service academic libraries provide based on demographic factors, gauging RDS growth since 2011, and what obstacles may prevent expansion or growth of services.

  12. Delivery through innovation: CSIR research on water services infrastructure operation through franchising

    CSIR Research Space (South Africa)

    Wall, K

    2006-02-01

    Full Text Available , has undertaken extensive research into an alternative service institutional concept, viz. water services infrastructure operation through franchising. This concept could be developed and made available to emerging entrepreneurs as the basis of a viable...

  13. Documentation system for plant transformation service and research.

    Science.gov (United States)

    Köhl, Karin I; Gremmels, Jürgen

    2010-01-27

    In plant transformation, method compliance is critical for success. Transformation methods are complicated and tend to evolve over time. Until the complete method is published, method details are often partially orally transmitted and thus bound to a few people. Their documentation in text files are often a mixture of material and method description with many references to other sources especially to media description. These media are complex and often composed from several commercially available mixtures plus individually prepared stocks. The actual transformation experiment is generally documented in lab books, in which deviations from the methods and results are reported. Additionally, work schedules are planned in diaries. Both paper-based sources lack backup copies and miss unambiguous links to method descriptions and media recipes. To solve the problem, we devised a standard-operation-procedure system based on a Microsoft Access database containing the interlinked modules 'Media', 'Methods' and 'Experiments'. The Media module contains all basic chemicals, stocks and complex media. In this module, complex media are composed from other elements of the Media module, thus mimicking the workflows of media preparation in the lab. The Media module is made attractive to the user by functions that generate file cards and labels. The Methods module describes each method stepwise and links the steps to the media. Copy functions allow cloning of old methods to document method evolution without alteration of the old methods. Activation and inactivation functions in the Media and the Methods module remove outdated entries from active use. The Experiments module links the method to experiment specific information. This module generates a lab-book like user interface and a work schedule, and it contains a simple result section. The system has been evolved and tested over several years in a transformation service unit, where it increased efficiency. Additionally, the system

  14. Documentation system for plant transformation service and research

    Directory of Open Access Journals (Sweden)

    Gremmels Jürgen

    2010-01-01

    Full Text Available Abstract Background In plant transformation, method compliance is critical for success. Transformation methods are complicated and tend to evolve over time. Until the complete method is published, method details are often partially orally transmitted and thus bound to a few people. Their documentation in text files are often a mixture of material and method description with many references to other sources especially to media description. These media are complex and often composed from several commercially available mixtures plus individually prepared stocks. The actual transformation experiment is generally documented in lab books, in which deviations from the methods and results are reported. Additionally, work schedules are planned in diaries. Both paper-based sources lack backup copies and miss unambiguous links to method descriptions and media recipes. Description To solve the problem, we devised a standard-operation-procedure system based on a Microsoft Access database containing the interlinked modules 'Media', 'Methods' and 'Experiments'. The Media module contains all basic chemicals, stocks and complex media. In this module, complex media are composed from other elements of the Media module, thus mimicking the workflows of media preparation in the lab. The Media module is made attractive to the user by functions that generate file cards and labels. The Methods module describes each method stepwise and links the steps to the media. Copy functions allow cloning of old methods to document method evolution without alteration of the old methods. Activation and inactivation functions in the Media and the Methods module remove outdated entries from active use. The Experiments module links the method to experiment specific information. This module generates a lab-book like user interface and a work schedule, and it contains a simple result section. Conclusion The system has been evolved and tested over several years in a transformation service

  15. Research in radiation biology, in the environment, and in radiation protection at CRNL

    International Nuclear Information System (INIS)

    Marko, A.M.; Myers, D.K.; Ophel, I.L.; Cowper, G.; Newcombe, H.B.

    1978-01-01

    Research in radiation biology at CRNL is concerned with: evaluation of the effects of low doses of radiation upon humans and other living organisms; the development of new methods for detecting the effects of radiation exposure in large populations; the continued development of improved methods by which radiation levels can be measured accurately and reliably; and evaluation of the effects of nuclear power use upon the environment. The present report summarizes our background knowledge of radiation hazards and describes current research activities in Biology and Health Physics Division at CRNL. (author)

  16. Breaking the Biological Barriers to Cellulosic Ethanol: A Joint Research Agenda

    Energy Technology Data Exchange (ETDEWEB)

    Houghton, John [Dept. of Energy (DOE), Washington DC (United States); Weatherwax, Sharlene [Dept. of Energy (DOE), Washington DC (United States); Ferrell, John [Dept. of Energy (DOE), Washington DC (United States)

    2006-06-07

    The Biomass to Biofuels Workshop, held December 7–9, 2005, was convened by the Department of Energy’s Office of Biological and Environmental Research in the Office of Science; and the Office of the Biomass Program in the Office of Energy Efficiency and Renewable Energy. The purpose was to define barriers and challenges to a rapid expansion of cellulosic-ethanol production and determine ways to speed solutions through concerted application of modern biology tools as part of a joint research agenda. Although the focus was ethanol, the science applies to additional fuels that include biodiesel and other bioproducts or coproducts having critical roles in any deployment scheme.

  17. From virus research to molecular biology: Tobacco mosaic virus in Germany, 1936-1956.

    Science.gov (United States)

    Lewis, Jeffrey

    2004-01-01

    In 1937, a group of researchers in Nazi Germany began investigating tobacco mosaic virus (TMV) with the hope of using the virus as a model system for understanding gene behavior in higher organisms. They soon developed a creative and interdisciplinary work style and were able to continue their research in the postwar era, when they made significant contributions to the history of molecular biology. This group is significant for two major reasons. First, it provides an example of how researchers were able to produce excellent scientific research in the midst of dictatorship and war. Coupled with the group's ongoing success in postwar Germany, the German TMV investigators provide a dramatic example of how scientific communities deal with adversity as well as rapid political and social change. Second, since the researchers focused heavily (though no exclusively) on TMV, their story allows us to analyze how an experimental system other than phage contributed to the emergence of molecular biology.

  18. A Framework for Improving the Quality of Research in the Biological Sciences

    Directory of Open Access Journals (Sweden)

    Arturo Casadevall

    2016-08-01

    Full Text Available The American Academy of Microbiology convened a colloquium to discuss problems in the biological sciences, with emphasis on identifying mechanisms to improve the quality of research. Participants from various disciplines made six recommendations: (i design rigorous and comprehensive evaluation criteria to recognize and reward high-quality scientific research; (ii require universal training in good scientific practices, appropriate statistical usage, and responsible research practices for scientists at all levels, with training content regularly updated and presented by qualified scientists; (iii establish open data at the timing of publication as the standard operating procedure throughout the scientific enterprise; (iv encourage scientific journals to publish negative data that meet methodologic standards of quality; (v agree upon common criteria among scientific journals for retraction of published papers, to provide consistency and transparency; and (vi strengthen research integrity oversight and training. These recommendations constitute an actionable framework that, in combination, could improve the quality of biological research.

  19. Team research at the biology-mathematics interface: project management perspectives.

    Science.gov (United States)

    Milton, John G; Radunskaya, Ami E; Lee, Arthur H; de Pillis, Lisette G; Bartlett, Diana F

    2010-01-01

    The success of interdisciplinary research teams depends largely upon skills related to team performance. We evaluated student and team performance for undergraduate biology and mathematics students who participated in summer research projects conducted in off-campus laboratories. The student teams were composed of a student with a mathematics background and an experimentally oriented biology student. The team mentors typically ranked the students' performance very good to excellent over a range of attributes that included creativity and ability to conduct independent research. However, the research teams experienced problems meeting prespecified deadlines due to poor time and project management skills. Because time and project management skills can be readily taught and moreover typically reflect good research practices, simple modifications should be made to undergraduate curricula so that the promise of initiatives, such as MATH-BIO 2010, can be implemented.

  20. Customized products and cloud service information system development research

    Directory of Open Access Journals (Sweden)

    Hung Chien-Wen

    2017-01-01

    Full Text Available This study presents a cloud service customized product information system to enable businesses to provide customized product marketing on the Internet to meet consumer demand for customized products. The cloud service of the information system development strategic framework proposed in this study contains three elements: (1 e-commerce services, (2 promotion type modules, and (3 cloud services customized promotional products. In this study, a mining cloud information system to detect customer behavior is proposed. The association rules from relational database design are utilized to mine consumer behavior to generate cross-selling proposals for customer products and marketing for a retailing mall in Taiwan. The study is composed of several parts, as follows. A market segment and application of association rules in data exploration techniques (Association Rule Mining and sequence-like exploration (Sequential Pattern Mining, efficient analysis of customers, consumer behavior, identification of candidates for promotional products, and using cloud service delivery and evaluation of targets to evaluate candidates for promotional products for production. However, in addition to cloud service customized promotional products, the quantity of promotional products sales varies for different customers. We strive to achieve increased customer loyalty and profits through the use of active cloud service customized promotional products.

  1. Spatial diversification of agroecosystems to enhance biological control and other regulating services: An agroecological perspective.

    Science.gov (United States)

    Hatt, Séverin; Boeraeve, Fanny; Artru, Sidonie; Dufrêne, Marc; Francis, Frédéric

    2018-04-15

    Spatial diversification of crop and non-crop habitats in farming systems is promising for enhancing natural regulation of insect pests. Nevertheless, results from recent syntheses show variable effects. One explanation is that the abundance and diversity of pests and natural enemies are affected by the composition, design and management of crop and non-crop habitats. Moreover, interactions between both local and landscape elements and practices carried out at different spatial scales may affect the regulation of insect pests. Hence, research is being conducted to understand these interdependencies. However, insects are not the only pests and pests are not the only elements to regulate in agroecosystems. Broadening the scope could allow addressing multiple issues simultaneously, but also solving them together by enhancing synergies. Indeed, spatial diversification of crop and non-crop habitats can allow addressing the issues of weeds and pathogens, along with being beneficial to several other regulating services like pollination, soil conservation and nutrient cycling. Although calls rise to develop multifunctional landscapes that optimize the delivery of multiple ecosystem services, it still represents a scientific challenge today. Enhancing interdisciplinarity in research institutions and building interrelations between scientists and stakeholders may help reach this goal. Despite obstacles, positive results from research based on such innovative approaches are encouraging for engaging science in this path. Hence, the aim of the present paper is to offer an update on these issues by exploring the most recent findings and discussing these results to highlight needs for future research. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Research and service capabilities of the National Nuclear Forensic Research Laboratory

    International Nuclear Information System (INIS)

    Romero G, E. T.; Hernandez M, H.; Flores C, J.; Paredes G, L. C.

    2016-09-01

    According to the recommendations of the International Atomic Energy Agency, Mexico is taking steps to combat illicit trafficking in nuclear material. The creation of a National Nuclear Forensic Research Laboratory (Lanafonu, acronym in Spanish) has been assigned to the Instituto Nacional de Investigaciones Nucleares (ININ, Mexico) in 2014. The objectives of this Laboratory are: to combat illicit trafficking in nuclear materials, to optimize scientific processes and techniques used to analyze nuclear materials (orphans or radioactive sources), environmental and potential biological sources as a result of the handling, transport and final storage. At present, the Lanafonu facilities are focused on the optimization of emergency and routine protocols for measuring radioisotopes in environmental and biological samples using inductive coupling mass spectrometer with magnetic sector. The main activities are: i) optimization of the methods for measuring the isotopes of Pu by alpha-spectrometry, Icp-SFMS and AMS (accelerator mass spectrometry), ii) development or radiochemical methods for routine situations and nuclear emergencies, iii) participation in the scientific technical commission on nuclear forensic science, iv) participation in international intercomparison exercises to optimize and validate methods, and v) consolidation of Lanafonu in Mexico and the IAEA. (Author)

  3. practice-oriented research in service of designing interventions

    African Journals Online (AJOL)

    research orientation of practice-oriented research. Many steps will be unfamiliar to readers who are acquainted with mainline qualitative and/or quantitative research (see our article on survey research). By following the stepwise process of developing a research design, we believe that we make it easier for the reader to ...

  4. Practice-oriented research in service of designing interventions ...

    African Journals Online (AJOL)

    The strength of the practice-oriented research strategy is to develop knowledge about the improvement of practices. Practice oriented research is research in which the research goal is coming from the professional practice and in which the knowledge created in the research contributes directly to this professional practice.

  5. Mixed-Methods Design in Biology Education Research: Approach and Uses.

    Science.gov (United States)

    Warfa, Abdi-Rizak M

    Educational research often requires mixing different research methodologies to strengthen findings, better contextualize or explain results, or minimize the weaknesses of a single method. This article provides practical guidelines on how to conduct such research in biology education, with a focus on mixed-methods research (MMR) that uses both quantitative and qualitative inquiries. Specifically, the paper provides an overview of mixed-methods design typologies most relevant in biology education research. It also discusses common methodological issues that may arise in mixed-methods studies and ways to address them. The paper concludes with recommendations on how to report and write about MMR. © 2016 L. A.-R. M. Warfa. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  6. Desegregating undergraduate mathematics and biology--interdisciplinary instruction with emphasis on ongoing biomedical research.

    Science.gov (United States)

    Robeva, Raina

    2009-01-01

    The remarkable advances in the field of biology in the last decade, specifically in the areas of biochemistry, genetics, genomics, proteomics, and systems biology, have demonstrated how critically important mathematical models and methods are in addressing questions of vital importance for these disciplines. There is little doubt that the need for utilizing and developing mathematical methods for biology research will only grow in the future. The rapidly increasing demand for scientists with appropriate interdisciplinary skills and knowledge, however, is not being reflected in the way undergraduate mathematics and biology courses are structured and taught in most colleges and universities nationwide. While a number of institutions have stepped forward and addressed this need by creating and offering interdisciplinary courses at the juncture of mathematics and biology, there are still many others at which there is little, if any, interdisciplinary interaction between the curricula. This chapter describes an interdisciplinary course and a textbook in mathematical biology developed collaboratively by faculty from Sweet Briar College and the University of Virginia School of Medicine. The course and textbook are designed to provide a bridge between the mathematical and biological sciences at the lower undergraduate level. The course is developed for and is being taught in a liberal arts setting at Sweet Briar College, Virginia, but some of the advanced modules are used in a course at the University of Virginia for advanced undergraduate and beginning graduate students. The individual modules are relatively independent and can be used as stand-alone projects in conventional mathematics and biology courses. Except for the introductory material, the course and textbook topics are based on current biomedical research.

  7. NATO Advanced Research Workshop, 19-22 May 1997: Rapid Method for Monitoring the Environment for Biological Hazards

    National Research Council Canada - National Science Library

    1997-01-01

    The NATO Advanced Research Workshop met for the purpose of bringing to light rapid methods for monitoring the environment for biological hazards such as biological warfare agents, naturally occurring...

  8. 77 FR 38291 - Meeting of the Advisory Council on Alzheimer's Research, Care, and Services

    Science.gov (United States)

    2012-06-27

    ... HUMAN SERVICES Meeting of the Advisory Council on Alzheimer's Research, Care, and Services AGENCY...: This notice announces the public meeting of the Advisory Council on Alzheimer's Research, Care, and... U.S.C. App. 2, section 10(a)(1) and (a)(2)). The Advisory Council on Alzheimer's Research, Care, and...

  9. Research and development portfolio of the sustainability science team national sustainable operations USDA Forest Service

    Science.gov (United States)

    Trista Patterson; David Nicholls; Jonathan Long

    2015-01-01

    The Sustainability Science Team (SST) of the U.S. Department of Agriculture (USDA) Forest Service Sustainable Operations Initiative is a 18-member virtual research and development team, located across five regions and four research stations of the USDA Forest Service. The team provides research, publication, systems analysis, and decision support to the Sustainable...

  10. Connecting biology and organic chemistry introductory laboratory courses through a collaborative research project.

    Science.gov (United States)

    Boltax, Ariana L; Armanious, Stephanie; Kosinski-Collins, Melissa S; Pontrello, Jason K

    2015-01-01

    Modern research often requires collaboration of experts in fields, such as math, chemistry, biology, physics, and computer science to develop unique solutions to common problems. Traditional introductory undergraduate laboratory curricula in the sciences often do not emphasize connections possible between the various disciplines. We designed an interdisciplinary, medically relevant, project intended to help students see connections between chemistry and biology. Second term organic chemistry laboratory students designed and synthesized potential polymer inhibitors or inducers of polyglutamine protein aggregation. The use of novel target compounds added the uncertainty of scientific research to the project. Biology laboratory students then tested the novel potential pharmaceuticals in Huntington's disease model assays, using in vitro polyglutamine peptide aggregation and in vivo lethality studies in Drosophila. Students read articles from the primary literature describing the system from both chemical and biological perspectives. Assessment revealed that students emerged from both courses with a deeper understanding of the interdisciplinary nature of biology and chemistry and a heightened interest in basic research. The design of this collaborative project for introductory biology and organic chemistry labs demonstrated how the local interests and expertise at a university can be drawn from to create an effective way to integrate these introductory courses. Rather than simply presenting a series of experiments to be replicated, we hope that our efforts will inspire other scientists to think about how some aspect of authentic work can be brought into their own courses, and we also welcome additional collaborations to extend the scope of the scientific exploration. © 2015 The International Union of Biochemistry and Molecular Biology.

  11. Species abundance and potential biological control services in shade vs. sun coffee in Puerto Rico

    Science.gov (United States)

    Borkhataria, Rena R.; Collazo, Jaime A.; Groom, Martha J.

    2012-01-01

    Birds, lizards and insects were surveyed in three sun and three shade coffee plantations in Puerto Rico to provide a comprehensive comparison of biodiversity between plantations types and to identify potential interrelationships (e.g., biological or natural control services) between members of each taxon and coffee pests. Abundance of avian species, including insectivorous species, was significantly higher in shade coffee. Anolis cristatellus and A. stratulus were significantly more abundant in sun plantations whereas A. gundlachi and A. evermanni were detected more frequently in shade plantations. Insects in the orders Coleoptera, Diptera, Hemiptera, Hymenoptera, Lepidoptera, Neuroptera, and Psocoptera were significantly more abundant in shade coffee, while orthopterans were more abundant in sun. The coffee leaf miner (Leucoptera coffeela) and the flatid planthopper (Petrusa epilepsis) did not differ significantly between plantation types, nor did the abundance of the wasp complex that parasitizes the coffee leaf miner. These findings confirmed that shade plantations harbor a wide array of elements of biodiversity; but sun plantations may also harbor many elements of biodiversity, and in some cases, in higher abundance than in shade plantations.

  12. Decommissioning of the ASTRA research reactor: Dismantling of the biological shield

    Directory of Open Access Journals (Sweden)

    Meyer Franz

    2006-01-01

    Full Text Available The paper describes the dismantling of the inactive and activated areas of the biological shield of the ASTRA research reactor at the Austrian Research Center in Seibersdorf. The calculation of the parameters determining the activated areas at the shield (reference nuclide, nuclide vector in the barite concrete and horizontal and vertical reduction behaviors of activity concentration and the activation profiles within the biological shield for unrestricted release, release restricted to permanent deposit and radioactive waste are presented. Considerations of located activation anomalies in the shield, e.g. in the vicinities of the beam-tubes, were made according to the reactor's operational history. Finally, an overview of the materials removed from the biological shield is given.

  13. Research to Advance the Development of River Information Services (RIS) Technologies

    Science.gov (United States)

    2016-12-01

    organisations Research to advance the Development of River Information Services (RIS) Technologies Page 12 © viadonau Final Report 4...Research to advance the Development of River Information Services (RIS) Technologies Final report Contracting period 09/2014 – 12/2016 Contract...Research to advance the Development of River Information Services (RIS) Technologies Page 2 © viadonau Final Report Table of content 1 Abstract

  14. Building Consensus in Science: Resources for Intertextual Dialog in Biology Research Articles

    Science.gov (United States)

    Martinez, Iliana A.

    2008-01-01

    This paper reports on the way article writers bring prior texts into biology research articles. It studies the functional moves in which citations occur and their formal features, providing a better understanding of the linguistic resources that are used to construct intertextuality in science. The results show the functions of citations were…

  15. The challenges for molecular nutrition research 4: the "nutritional systems biology level"

    NARCIS (Netherlands)

    Ommen, B. van; Cavallieri, D.; Roche, H.M.; Klein, U.I.; Daniel, H.

    2008-01-01

    Nutritional systems biology may be defined as the ultimate goal of molecular nutrition research, where all relevant aspects of regulation of metabolism in health and disease states at all levels of its complexity are taken into account to describe the molecular physiology of nutritional processes.

  16. Connecting Biology and Organic Chemistry Introductory Laboratory Courses through a Collaborative Research Project

    Science.gov (United States)

    Boltax, Ariana L.; Armanious, Stephanie; Kosinski-Collins, Melissa S.; Pontrello, Jason K.

    2015-01-01

    Modern research often requires collaboration of experts in fields, such as math, chemistry, biology, physics, and computer science to develop unique solutions to common problems. Traditional introductory undergraduate laboratory curricula in the sciences often do not emphasize connections possible between the various disciplines. We designed an…

  17. 76 FR 59407 - Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and...

    Science.gov (United States)

    2011-09-26

    ... searching for articles using a PubMed and/or Institute for Scientific Information (ISI) search engine...] Center for Biologics Evaluation and Research Report of Scientific and Medical Literature and Information... Administration (FDA) is announcing the availability of its report of scientific and medical literature and...

  18. Infusing Bioinformatics and Research-Like Experience into a Molecular Biology Laboratory Course

    Science.gov (United States)

    Nogaj, Luiza A.

    2014-01-01

    A nine-week laboratory project designed for a sophomore level molecular biology course is described. Small groups of students (3-4 per group) choose a tumor suppressor gene (TSG) or an oncogene for this project. Each group researches the role of their TSG/oncogene from primary literature articles and uses bioinformatics engines to find the gene…

  19. RESEARCH OF QUALITY, SAFETY AND CONTENT OF BIOLOGICALLY ACTIVE SUBSTANCES OF FOOD RED BEET

    OpenAIRE

    Gorash E. Y.; Victorova E. P.; Kupin G. A.; Aleshin V. N.; Lisovoy V. V.

    2015-01-01

    The article presents results of research of quality, safety and content of biologically active substances of food red beet roots of Bordo 237 variety, grown in the Krasnodar region in 2014. On the basis of the research carried out it was established, that there are carbohydrates, proteins, organic acids and mineral substances in the food red beet roots of Bordo 237 variety. Food red beet roots are a source of dietary fibers (pectin, protopectin, hemicelluloses and cellulose), possessing antit...

  20. Parent perspectives on privacy and governance for a pediatric repository of non-biological, research data.

    Science.gov (United States)

    Manhas, Kiran P; Page, Stacey; Dodd, Shawn X; Letourneau, Nicole; Ambrose, Aleta; Cui, Xinjie; Tough, Suzanne C

    2015-02-01

    Research data repositories (RDRs) are data storage entities where data can be submitted, stored, and subsequently accessed for purposes beyond the original intent. There is little information relating to non-biological RDRs, nor considerations regarding pediatric data storage and re-use. We examined parent perspectives on pediatric, non-biological RDRs. Qualitative, descriptive methods including both interviews and focus groups were used. Purposive sampling of adult participants in two provincial birth cohorts yielded 19 interviewees and 18 focus group participants (4 groups). Transcripts were analyzed by thematic content analysis. Parent research participants strongly supported the sharing of their own, and their child's, non-biological research data. Four themes emerged: that altruism has limits, that participants have ongoing privacy concerns, that some participants need the assurance of congruent values between themselves and researchers/research questions, and that opinions diverge for some governance issues. The establishment of RDRs is important and maximizes participants', researchers', and funders' investments. Participants as data donors have concerns relating to privacy, relationships, and governance that must be considered in RDR development. © The Author(s) 2014.

  1. Skills Issues in Other Business Services: Professional Services. Skills Task Force Research Paper 16.

    Science.gov (United States)

    Penn, Roger; Holt, Richard

    "Creative business services" have grown rapidly in Great Britain and are important in terms of their impact on the economy, including their contribution to international trade. They have helped and been boosted by such business changes as privatization, spread of information technology (IT), and contracting out of services. The sectors…

  2. Review on Invasive Tree of Heaven (Ailanthus altissima (Mill.) Swingle) Conflicting Values: Assessment of Its Ecosystem Services and Potential Biological Threat.

    Science.gov (United States)

    Sladonja, Barbara; Sušek, Marta; Guillermic, Julia

    2015-10-01

    Globally, invasions by alien plants are rapidly increasing in extent and severity, leading to large-scale ecosystem degradation. One of the most widespread invasive alien plant species in Europe and North America, Tree of Heaven (Ailanthus altissima (Mill.) Swingle) was introduced intentionally for use as an ornamental plant in the 18th century. Since then, it has spread and is now frequently found in a number of countries. Today, Tree of Heaven is considered one of the worst invasive plant species in Europe and is also listed as invasive in North America and many other countries. Millennium Ecosystem Assessment is one of many systems trying to list and categorize biological services to humans and to provide a tool for identifying services delivered by natural ecosystems. Invasive species have generally caused degradation of the services, have a major impact on the environment, and are threatening biodiversity and reducing overall species abundance and diversity. On the other hand, some invasive species can provide services useful to human well-being. In the present review A. altissima impacts on ecosystems are identified and positive influences on some ecosystem services are weighed against the negative effects on the environment and human health. The aim of the present review is to resume the general knowledge of A. altissima, group available references on distribution and ecology according to countries, compare ecosystem services provided or enhanced by A. altissima presence and the negative effects it causes, identify gaps in current knowledge, and give recommendations for future lines of research.

  3. Collaborative international research: ethical and regulatory issues pertaining to human biological materials at a South African institutional research ethics committee.

    Science.gov (United States)

    Sathar, Aslam; Dhai, Amaboo; van der Linde, Stephan

    2014-12-01

    Human Biological Materials (HBMs) are an invaluable resource in biomedical research. To determine if researchers and a Research Ethics Committee (REC) at a South African institution addressed ethical issues pertaining to HBMs in collaborative research with developed countries. Ethically approved retrospective cross-sectional descriptive audit. Of the 1305 protocols audited, 151 (11.57%) fulfilled the study's inclusion criteria. Compared to other developed countries, a majority of sponsors (90) were from the USA (p = 0.0001). The principle investigators (PIs) in all 151 protocols informed the REC of their intent to store HBMs. Only 132 protocols informed research participants (P research participants, 116 protocols (76.8%) solicited broad consent compared to specific consent (32; 21.2%) [p research participants (67) that HBMs would be exported (p = 0.011). Export permits (EPs) and Material Transfer Agreements (MTAs) were not available in 109 and 143 protocols, respectively. Researchers and the REC did not adequately address the inter-related ethical and regulatory issues pertaining to HBMs. There was a lack of congruence between the ethical guidelines of developed countries and their actions which are central to the access to HBMs in collaborative research. HBMs may be leaving South Africa without EPs and MTAs during the process of international collaborative research. © 2013 John Wiley & Sons Ltd.

  4. RESEARCH ON MOBILE CONSUMER HABIT AND ATTITUDE TOWARDS FEMTOCELL SERVICES

    Directory of Open Access Journals (Sweden)

    Novika Chandra Astuti

    2017-04-01

    Full Text Available Femtocell is the new technology that may offer competitive value to mobile service providers for increasing their market share, retain the consumers and lower the operational cost ini providing the better signal especially inside building (indoor. This study investigate the habit and attitude of mobile consumers int two specific areas in Bandung; Buah Batu Regency and Mitra Dago-Antapani, toward the use of femtocell value and services. This study also considers the marketing implication the success of femtocell deployment in the future

  5. The use of "mixing" procedure of mixed methods in health services research.

    Science.gov (United States)

    Zhang, Wanqing; Creswell, John

    2013-08-01

    Mixed methods research has emerged alongside qualitative and quantitative approaches as an important tool for health services researchers. Despite growing interest, among health services researchers, in using mixed methods designs, little has been done to identify the procedural aspects of doing so. To describe how mixed methods researchers mix the qualitative and quantitative aspects of their studies in health services research. We searched the PubMed for articles, using mixed methods in health services research, published between January 1, 2006 and December 30, 2010. We identified and reviewed 30 published health services research articles on studies in which mixed methods had been used. We selected 3 articles as illustrations to help health services researcher conceptualize the type of mixing procedures that they were using. Three main "mixing" procedures have been applied within these studies: (1) the researchers analyzed the 2 types of data at the same time but separately and integrated the results during interpretation; (2) the researchers connected the qualitative and quantitative portions in phases in such a way that 1 approach was built upon the findings of the other approach; and (3) the researchers mixed the 2 data types by embedding the analysis of 1 data type within the other. "Mixing" in mixed methods is more than just the combination of 2 independent components of the quantitative and qualitative data. The use of "mixing" procedure in health services research involves the integration, connection, and embedding of these 2 data components.

  6. The EBI search engine: EBI search as a service-making biological data accessible for all.

    Science.gov (United States)

    Park, Young M; Squizzato, Silvano; Buso, Nicola; Gur, Tamer; Lopez, Rodrigo

    2017-07-03

    We present an update of the EBI Search engine, an easy-to-use fast text search and indexing system with powerful data navigation and retrieval capabilities. The interconnectivity that exists between data resources at EMBL-EBI provides easy, quick and precise navigation and a better understanding of the relationship between different data types that include nucleotide and protein sequences, genes, gene products, proteins, protein domains, protein families, enzymes and macromolecular structures, as well as the life science literature. EBI Search provides a powerful RESTful API that enables its integration into third-party portals, thus providing 'Search as a Service' capabilities, which are the main topic of this article. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  7. The Impact of Internet Services on the Research Output of Academic ...

    African Journals Online (AJOL)

    This study investigated the impact of internet services on the research output of aca demic staff of selected state universities in South -Western Nigeria and examin ed the extent to which academic staff of state universities embraced computer literacy and utilised internet services . It also considered how internet services had ...

  8. RIMS: The Research Impact Measurement Service at the University of New South Wales

    Science.gov (United States)

    Drummond, Robyn; Wartho, Richard

    2009-01-01

    In 2005, the Library at UNSW began a comprehensive restructuring process that fundamentally changed the provision of services to its academic community. A primary aim of this process was to increase flexibility of service development and delivery and so to improve research support. The motivation for reformed services arose from considerations…

  9. Developing Library GIS Services for Humanities and Social Science: An Action Research Approach

    Science.gov (United States)

    Kong, Ningning; Fosmire, Michael; Branch, Benjamin Dewayne

    2017-01-01

    In the academic libraries' efforts to support digital humanities and social science, GIS service plays an important role. However, there is no general service model existing about how libraries can develop GIS services to best engage with digital humanities and social science. In this study, we adopted the action research method to develop and…

  10. Scientific works of research workers of the army health service

    International Nuclear Information System (INIS)

    1995-01-01

    Ten articles about the effects of gamma radiation on human or animal cells are studied here. Regulation of cytokines, effect of interleukin 6, expression of the C-fos protein, interest of the study of a biological check up after an accidental irradiation, interaction and transport of cysteamine( radioprotector), approach of a treatment of radioinduced medullary aplasia, expression of TNF alpha and gelatinase B, are the subjects related here. (N.C.)

  11. Delivering Human Services to the Rural Elderly: Implications From Research.

    Science.gov (United States)

    Kerckhoff, Richard K.; Coward, Raymond T.

    Consistent with the national population growth pattern for nonmetropolitan areas, demographers have identified a significant shift in the residence of persons 65 years or older. In conjunction with an increased awareness of the discrepancy between the availability of human services for the elderly in urban and rural communities, establishment of a…

  12. Avian research in the U.S. Forest Service

    Science.gov (United States)

    Beatrice Van Horne

    2005-01-01

    Avian research in the Federal Government is in a crisis. Yes, there is a strong interest in avian research, as evidenced by the size and level of interest in this conference. But political parties increasingly see wildlife research as expendable. At the same time, the reaction to environment-friendly legislation of the 1970s and 1980s has been strong from both sides....

  13. The Development of Qualitative Classroom Action Research Workshop for In-Service Science Teachers

    Science.gov (United States)

    Buaraphan, Khajornsak

    2016-01-01

    In-service science teachers in Thailand are mandated to conduct classroom research, which can be quantitative and qualitative research, to improve teaching and learning. Comparing to quantitative research, qualitative research is a research approach that most of the Thai science teachers are not familiar with. This situation impedes science…

  14. Role of nuclear analytical probe techniques in biological trace element research

    International Nuclear Information System (INIS)

    Jones, K.W.; Pounds, J.G.

    1985-01-01

    Many biomedical experiments require the qualitative and quantitative localization of trace elements with high sensitivity and good spatial resolution. The feasibility of measuring the chemical form of the elements, the time course of trace elements metabolism, and of conducting experiments in living biological systems are also important requirements for biological trace element research. Nuclear analytical techniques that employ ion or photon beams have grown in importance in the past decade and have led to several new experimental approaches. Some of the important features of these methods are reviewed here along with their role in trace element research, and examples of their use are given to illustrate potential for new research directions. It is emphasized that the effective application of these methods necessitates a closely integrated multidisciplinary scientific team. 21 refs., 4 figs., 1 tab

  15. Providing access to research data, publications and current research information at Data Archiving and Networked Services - DANS

    NARCIS (Netherlands)

    Dijk, E.M.S.; Doorn, P.K.

    2014-01-01

    Data Archiving and Networked Services (DANS) promotes sustained access to digital research data in the Netherlands. Researchers can deposit their data through the online archiving system EASY. Via the portal NARCIS the research data are shown in context, namely in relation to publications, and other

  16. A Practical Guide to Using the Positive Deviance Method in Health Services Research.

    Science.gov (United States)

    Rose, Adam J; McCullough, Megan B

    2017-06-01

    To provide practical tips for health services researchers considering the use of positive deviance (PD) methods to help explain variations in quality of care or other meaningful parameters. Published literature and personal experience. Narrative review. This review includes a discussion of possible applications of PD to health services research, some methodological choices applicable to PD, and some brief tips regarding publishing the results and incorporating them into future interventions. It is hoped that this article will help health services researchers to use this valuable research method more effectively, especially those who have not done so before. © Health Research and Educational Trust.

  17. Utilization of Service Design in Tourism : Mobile Ethnographic Research in a Ski Resort

    OpenAIRE

    Leinonen, Mikko

    2012-01-01

    Savonia University of Applied Sciences attended as a partner on an international Service Design in Tourism co-operation pilot project, where the functionality, utilization and efficiency of the service design was simultaneously tested in seven different nations in order to enhance and to develop travel services. MyServiceFellow mobile ethnographic research was conducted between the dates of 27.12.2011 and 11.3.2012 in Tahko tourism resort, located in Central Finland. The central aim of...

  18. Research in medical education: balancing service and science.

    Science.gov (United States)

    Albert, Mathieu; Hodges, Brian; Regehr, Glenn

    2007-02-01

    Since the latter part of the 1990's, the English-speaking medical education community has been engaged in a debate concerning the types of research that should have priority. To shed light on this debate and to better understand its implications for the practice of research, 23 semi-structured interviews were conducted with "influential figures" from the community. The results were analyzed using the concept of "field" developed by the sociologist Pierre Bourdieu. The results reveal that a large majority of these influential figures believe that research in medical education continues to be of insufficient quality despite the progress that has taken place over the past 2 decades. According to this group, studies tend to be both redundant and opportunistic, and researchers tend to have limited understanding of both theory and methodological practice from the social sciences. Three factors were identified by the participants to explain the current problems in research: the working conditions of researchers, budgetary restraints in financing research in medical education, and the conception of research in the medical environment. Two principal means for improving research are presented: intensifying collaboration between PhD's and clinicians, and encouraging the diversification of perspectives brought to bear on research in medical education.

  19. Research traceability using provenance services for biomedical analysis.

    Science.gov (United States)

    Anjum, Ashiq; Bloodsworth, Peter; Branson, Andrew; Habib, Irfan; McClatchey, Richard; Solomonides, Tony; Soomro, Kamran; The Neugrid Consortium

    2010-01-01

    We outline the approach being developed in the neuGRID project to use provenance management techniques for the purposes of capturing and preserving the provenance data that emerges in the specification and execution of workflows in biomedical analyses. In the neuGRID project a provenance service has been designed and implemented that is intended to capture, store, retrieve and reconstruct the workflow information needed to facilitate users in conducting user analyses. We describe the architecture of the neuGRID provenance service and discuss how the CRISTAL system from CERN is being adapted to address the requirements of the project and then consider how a generalised approach for provenance management could emerge for more generic application to the (Health)Grid community.

  20. Laboratory services series: the utilization of scientific glassblowing in a national research and development laboratory

    International Nuclear Information System (INIS)

    Farnham, R.M.; Poole, R.W.

    1976-04-01

    Glassblowing services at a national research and development laboratory provide unique equipment tailored for specific research efforts, small-scale process items for flowsheet demonstrations, and solutions for unusual technical problems such as glass-ceramic unions. Facilities, equipment, and personnel necessary for such services are described

  1. 76 FR 5650 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2011-02-01

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that a meeting of the Rehabilitation Research and Development Service Scientific Merit Review Board will be held February 23-25 and March 1-2, 2011, at the Doubletree...

  2. 77 FR 21622 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2012-04-10

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that a meeting of the Rehabilitation Research and Development Service Scientific Merit Review Board will be held on April 20, 2012, 131 M Street NE., Washington, DC...

  3. 75 FR 72872 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-11-26

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that a meeting of the Rehabilitation Research and Development Service Scientific Merit Review Board will be held on December 13-14, 2010, at the Hilton Alexandria Old...

  4. 78 FR 50144 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meetings

    Science.gov (United States)

    2013-08-16

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... Advisory Committee Act, 5 U.S.C. App. 2, that the subcommittees of the Rehabilitation Research and Development Service Scientific Merit Review Board will meet from 8 a.m. to 5 p.m. on the dates indicated below...

  5. 76 FR 42167 - Rehabilitation Research and Development Service Scientific Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2011-07-18

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit...-463 (Federal Advisory Committee Act) that a meeting of the Rehabilitation Research and Development Service Scientific Merit Review Board will be held August 9-11 and 16-18, 2011, at the Sheraton Crystal...

  6. 78 FR 9455 - Rehabilitation Research and Development Service Scientific Merit Review Board, Notice of Meeting

    Science.gov (United States)

    2013-02-08

    ... DEPARTMENT OF VETERANS AFFAIRS Rehabilitation Research and Development Service Scientific Merit... Advisory Committee Act, 5 U.S.C. App. 2, that the subcommittees of the Rehabilitation Research and Development Service Scientific Merit Review Board will meet from 8 a.m. to 5 p.m. on the dates indicated below...

  7. "We Serve You, Right?" A Case Study Adapting Coorientation to Customer Service Research

    Science.gov (United States)

    Williamson, JoAnna

    2010-01-01

    An abundance of academic research has focused on identifying, explicating, operationalizing, and analyzing variables used to understand the dynamics of customer service. Despite this scholarly attention, applied researchers and the popular press have long reported consumers' dissatisfaction with the service received during their customer…

  8. Research-Based Program Development: Refining the Service Model for a Geographic Alliance

    Science.gov (United States)

    Rutherford, David J.; Lovorn, Carley

    2018-01-01

    Research conducted in 2013 identified the perceptions that K-12 teachers and administrators hold with respect to: (1) the perceived needs in education, (2) the professional audiences that are most important to reach, and (3) the service models that are most effective. The specific purpose of the research was to refine and improve the services that…

  9. Laboratory services series: the utilization of scientific glassblowing in a national research and development laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Farnham, R.M.; Poole, R.W.

    1976-04-01

    Glassblowing services at a national research and development laboratory provide unique equipment tailored for specific research efforts, small-scale process items for flowsheet demonstrations, and solutions for unusual technical problems such as glass-ceramic unions. Facilities, equipment, and personnel necessary for such services are described.

  10. The Evolution of Research and Information Services at the American Federation of Teachers.

    Science.gov (United States)

    Nelson, F. Howard; Bailey, Bernadette

    2002-01-01

    Provides a history of the American Federation of Teachers (AFT) union and its information services and research functions. Examines the research department and the influence of technology, shifting from collecting information to using information from the Internet and online databases that has made access easier. Analyzes information services with…

  11. Understanding ecosystem services adoption by natural resource managers and research ecologists

    Science.gov (United States)

    Engel, Daniel; Evans, Mary; Low, Bobbi S.; Schaeffer, Jeff

    2017-01-01

    The ecosystem services (ES) paradigm has gained much traction as a natural resource management approach due to its comprehensive nature and ability to provide quantitative tools to improve decision-making. However, it is still uncertain whether and how practitioners have adopted the ES paradigm into their work and how this aligns with resource management information needs. To address this, we surveyed natural resource managers within the Great Lakes region about their use of ES information in decision-making. We complemented our manager survey with in-depth interviews of a related population—research ecologists at the U.S. Geological Survey Great Lakes Science Center. In this study, managers and ecologists almost unanimously agreed that ES were appropriate to consider in resource management. We also found high congruence between managers and ecologists in the ES considered most relevant to their work, with provision of habitat, recreation and tourism, biological control, and primary production being the ES ranked highly by both groups. However, a disconnect arose when research ecologists deemed the information they provide regarding ES as adequate for management needs, but managers disagreed. Furthermore, managers reported that they would use economic information about ES if they had access to that information. We believe this data deficiency could represent a gap in scientific coverage by ecologists, but it may also simply reflect an underrepresentation of ecological economists who can translate ecological knowledge of ES providers into economic information that many managers desired.

  12. SINGLE MOLECULE APPROACHES TO BIOLOGY, 2010 GORDON RESEARCH CONFERENCE, JUNE 27-JULY 2, 2010, ITALY

    Energy Technology Data Exchange (ETDEWEB)

    Professor William Moerner

    2010-07-09

    The 2010 Gordon Conference on Single-Molecule Approaches to Biology focuses on cutting-edge research in single-molecule science. Tremendous technical developments have made it possible to detect, identify, track, and manipulate single biomolecules in an ambient environment or even in a live cell. Single-molecule approaches have changed the way many biological problems are addressed, and new knowledge derived from these approaches continues to emerge. The ability of single-molecule approaches to avoid ensemble averaging and to capture transient intermediates and heterogeneous behavior renders them particularly powerful in elucidating mechanisms of biomolecular machines: what they do, how they work individually, how they work together, and finally, how they work inside live cells. The burgeoning use of single-molecule methods to elucidate biological problems is a highly multidisciplinary pursuit, involving both force- and fluorescence-based methods, the most up-to-date advances in microscopy, innovative biological and chemical approaches, and nanotechnology tools. This conference seeks to bring together top experts in molecular and cell biology with innovators in the measurement and manipulation of single molecules, and will provide opportunities for junior scientists and graduate students to present their work in poster format and to exchange ideas with leaders in the field. A number of excellent poster presenters will be selected for short oral talks. Topics as diverse as single-molecule sequencing, DNA/RNA/protein interactions, folding machines, cellular biophysics, synthetic biology and bioengineering, force spectroscopy, new method developments, superresolution imaging in cells, and novel probes for single-molecule imaging will be on the program. Additionally, the collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings in the beauty of the Il Ciocco site in

  13. The Protein Information Management System (PiMS): a generic tool for any structural biology research laboratory.

    Science.gov (United States)

    Morris, Chris; Pajon, Anne; Griffiths, Susanne L; Daniel, Ed; Savitsky, Marc; Lin, Bill; Diprose, Jonathan M; da Silva, Alan Wilter; Pilicheva, Katya; Troshin, Peter; van Niekerk, Johannes; Isaacs, Neil; Naismith, James; Nave, Colin; Blake, Richard; Wilson, Keith S; Stuart, David I; Henrick, Kim; Esnouf, Robert M

    2011-04-01

    The techniques used in protein production and structural biology have been developing rapidly, but techniques for recording the laboratory information produced have not kept pace. One approach is the development of laboratory information-management systems (LIMS), which typically use a relational database schema to model and store results from a laboratory workflow. The underlying philosophy and implementation of the Protein Information Management System (PiMS), a LIMS development specifically targeted at the flexible and unpredictable workflows of protein-production research laboratories of all scales, is described. PiMS is a web-based Java application that uses either Postgres or Oracle as the underlying relational database-management system. PiMS is available under a free licence to all academic laboratories either for local installation or for use as a managed service.

  14. Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases.

    Science.gov (United States)

    Oh, Soo Jin; Choi, Young Ki; Shin, Ok Sarah

    2018-03-01

    Emerging infectious diseases (EIDs) pose a major threat to public health and security. Given the dynamic nature and significant impact of EIDs, the most effective way to prevent and protect against them is to develop vaccines in advance. Systems biology approaches provide an integrative way to understand the complex immune response to pathogens. They can lead to a greater understanding of EID pathogenesis and facilitate the evaluation of newly developed vaccine-induced immunity in a timely manner. In recent years, advances in high throughput technologies have enabled researchers to successfully apply systems biology methods to analyze immune responses to a variety of pathogens and vaccines. Despite recent advances, computational and biological challenges impede wider application of systems biology approaches. This review highlights recent advances in the fields of systems immunology and vaccinology, and presents ways that systems biology-based platforms can be applied to accelerate a deeper understanding of the molecular mechanisms of immunity against EIDs. © Copyright: Yonsei University College of Medicine 2018.

  15. Research and Development Strategy in Biological Technologies: A Patent Data Analysis of Japanese Manufacturing Firms

    Directory of Open Access Journals (Sweden)

    Hidemichi Fujii

    2016-04-01

    Full Text Available Biological technology allows us to invent new medical approaches, create effective food production methods and reserves and develop new materials for industrial production. There is a diversity of biological technology types, and different technologies have different priorities for invention. This study examines the factors that are important for the invention of biology-related technologies in Japan using patent application data and a decomposition analysis framework. As the results show, patent applications related to biochemistry and biotechnology increased until 1995 because of the expanded scale of R&D activities and the high priority assigned to biological technology. However, the number of patent applications stagnated after 1995, because the importance of biochemistry, especially waste-gas treatment technologies, decreased. Additionally, patent applications for medicines and disease-related technologies increased rapidly from 1971 to 1995. The primary determinant of rapid growth is an increase in research priority, especially among firms in the chemical industry whose technologies are related to supplemental foods and foods with health-promoting benefits. Finally, patent applications involving foodstuff- and agriculture-related technologies increased from 1971 to 1995 due to increased R&D and the increased priority of biological technology.

  16. Is systems biology a promising approach to resolve controversies in cancer research?

    Directory of Open Access Journals (Sweden)

    Soto Ana M

    2012-03-01

    Full Text Available Abstract At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In cancer research, instead of this healthy "weeding-out" process, there have been attempts to reach a premature synthesis, while no hypothesis is being rejected. Systems Biology could help cancer research to overcome this stalemate by resolving contradictions and identifying spurious data. First, in silico experiments should allow cancer researchers to be bold and a priori reject sets of data and hypotheses in order to gain a deeper understanding of how each dataset and each hypothesis contributes to the overall picture. In turn, this process should generate novel hypotheses and rules, which could be explored using these in silico approaches. These activities are significantly less costly and much faster than "wet-experiments". Consequently, Systems Biology could be advantageously used both as a heuristic tool to guide "wet-experiments" and to refine hypotheses and test predictions.

  17. 75 FR 4453 - Health Services Research and Development Service Merit Review Board; Notice of Meeting

    Science.gov (United States)

    2010-01-27

    ... testing of new methods of health care delivery and management, and nursing research. Applications are... Research and Development Officer. On March 2, the subcommittee on Nursing Research Initiative will convene.... Nursing Research Initiative (NRI) Review 8 a.m.-5 p.m. Career Development Award (CDA) Review 4:30 p.m.-5...

  18. Researching the Nokia Mobile Mathematics Service in South Africa

    African Journals Online (AJOL)

    To explore the efficacy of using mobile learning to support Mathematics performance at secondary school level, a development and research intervention was implemented in 30 public schools, targeting 4,000 Grade 10. Mathematics learners in South Africa. Research was focused on measuring the effect of providing a free ...

  19. Enhancing Reuse of Data and Biological Material in Medical Research: From FAIR to FAIR-Health.

    Science.gov (United States)

    Holub, Petr; Kohlmayer, Florian; Prasser, Fabian; Mayrhofer, Michaela Th; Schlünder, Irene; Martin, Gillian M; Casati, Sara; Koumakis, Lefteris; Wutte, Andrea; Kozera, Łukasz; Strapagiel, Dominik; Anton, Gabriele; Zanetti, Gianluigi; Sezerman, Osman Ugur; Mendy, Maimuna; Valík, Dalibor; Lavitrano, Marialuisa; Dagher, Georges; Zatloukal, Kurt; van Ommen, GertJan B; Litton, Jan-Eric

    2018-01-23

    The known challenge of underutilization of data and biological material from biorepositories as potential resources for medical research has been the focus of discussion for over a decade. Recently developed guidelines for improved data availability and reusability-entitled FAIR Principles (Findability, Accessibility, Interoperability, and Reusability)-are likely to address only parts of the problem. In this article, we argue that biological material and data should be viewed as a unified resource. This approach would facilitate access to complete provenance information, which is a prerequisite for reproducibility and meaningful integration of the data. A unified view also allows for optimization of long-term storage strategies, as demonstrated in the case of biobanks. We propose an extension of the FAIR Principles to include the following additional components: (1) quality aspects related to research reproducibility and meaningful reuse of the data, (2) incentives to stimulate effective enrichment of data sets and biological material collections and its reuse on all levels, and (3) privacy-respecting approaches for working with the human material and data. These FAIR-Health principles should then be applied to both the biological material and data. We also propose the development of common guidelines for cloud architectures, due to the unprecedented growth of volume and breadth of medical data generation, as well as the associated need to process the data efficiently.

  20. Transfusion research priorities for blood services in sub-Saharan Africa.

    Science.gov (United States)

    Bates, Imelda; Hassall, Oliver; Mapako, Tonderai

    2017-06-01

    Evidence to support many blood transfusion policies and practices in sub-Saharan Africa (SSA) is weak or lacking. SSA cannot extrapolate from wealthy countries' research findings because its environment, users and structures are very different and SSA has critical blood shortages. SSA needs to generate its own evidence but research funds are very scarce and need to be carefully targeted to match need. This study aimed to define this need by determining research priorities for blood services in SSA. Thirty-five stakeholders representing diverse blood services' interests and expertise participated in a workshop. An adapted 'consensus development method' was used to identify, agree and justify research priorities under five themes through small group and plenary discussion, and cumulative voting. Research priorities covered traditional research areas, such as clinical use of blood and infection screening, but also highlighted many new, under-researched topics, mostly concerning blood service 'systems', such as economics, blood components and regulation. Lack of electronic information management systems was an important hindrance to the blood services' ability to generate robust research data. This study has identified and prioritised novel research that will help blood services in SSA to address their own needs including their most urgent problem: the lack of access to adequate blood supplies. To catalyse this research blood services in SSA need to enhance their capacity to conduct, commission and manage research and to strengthen their collaborations within and beyond Africa. © 2017 John Wiley & Sons Ltd.

  1. Grand Challenges for Biological and Environmental Research: A Long-Term Vision

    Energy Technology Data Exchange (ETDEWEB)

    Arkin, A.; Baliga, N.; Braam, J.; Church, G.; Collins, J; ; Cottingham, R.; Ecker, J.; Gerstein, M.; Gilna, P.; Greenberg, J.; Handelsman, J.; Hubbard, S.; Joachimiak, A.; Liao, J.; Looger, L.; Meyerowitz, E.; Mjolness, E.; Petsko, G.; Sayler, G.; Simpson, M.; Stacey, G.; Sussman, M.; Tiedje, J.; Bader, D.; Cessi, P.; Collins, W.; Denning, S.; Dickinson, R.; Easterling, D.; Edmonds, J.; Feddema, J.; Field, C.; Fridlind, A.; Fung, I.; Held, I.; Jackson, R.; Janetos, A.; Large, W.; Leinen, M.; Leung, R.; Long, S.; Mace, G.; Masiello, C.; Meehl, G.; Ort, D.; Otto-Bliesner, B.; Penner, J.; Prather, M.; Randall, D.; Rasch, P.; Schneider, E.; Shugart, H.; Thornton, P.; Washington, W.; Wildung, R.; Wiscombe, W.; Zak, D.; Zhang, M.; Bielicki, J.; Buford, M.; Cleland, E.; Dale, V.; Duke, C.; Ehleringer, J.; Hecht, A.; Kammen, D.; Marland, G.; Pataki, D.; Riley, M. Robertson, P.; Hubbard, S.

    2010-12-01

    The interactions and feedbacks among plants, animals, microbes, humans, and the environment ultimately form the world in which we live. This world is now facing challenges from a growing and increasingly affluent human population whose numbers and lifestyles are driving ever greater energy demand and impacting climate. These and other contributing factors will make energy and climate sustainability extremely difficult to achieve over the 20-year time horizon that is the focus of this report. Despite these severe challenges, there is optimism that deeper understanding of our environment will enable us to mitigate detrimental effects, while also harnessing biological and climate systems to ensure a sustainable energy future. This effort is advanced by scientific inquiries in the fields of atmospheric chemistry and physics, biology, ecology, and subsurface science - all made possible by computing. The Office of Biological and Environmental Research (BER) within the Department of Energy's (DOE) Office of Science has a long history of bringing together researchers from different disciplines to address critical national needs in determining the biological and environmental impacts of energy production and use, characterizing the interplay of climate and energy, and collaborating with other agencies and DOE programs to improve the world's most powerful climate models. BER science focuses on three distinct areas: (1) What are the roles of Earth system components (atmosphere, land, oceans, sea ice, and the biosphere) in determining climate? (2) How is the information stored in a genome translated into microbial, plant, and ecosystem processes that influence biofuel production, climate feedbacks, and the natural cycling of carbon? (3) What are the biological, geochemical, and physical forces that govern the behavior of Earth's subsurface environment? Ultimately, the goal of BER science is to support experimentation and modeling that can reliably predict the

  2. [Research progress and trend analysis of biology and chemistry of Taxus medicinal resources].

    Science.gov (United States)

    Hao, Da-Cheng; Xiao, Pei-Gen; Peng, Yong; Liu, Ming; Huo, Li

    2012-07-01

    Taxus is the source plant of anti-cancer drug paclitaxel and its biosynthetic precursor, analogs and derivatives, which has been studying for decades. There are many endemic Taxus species in China, which have been studied in the field of multiple disciplines. Based on the recent studies of the researchers, this review comments on the study of Taxus biology and chemistry. The bibliometric method is used to quantify the global scientific production of Taxus-related research, and identify patterns and tendencies of Taxus-related articles. Gaps are present in knowledge about the genomics, epigenomics, transcriptomics, proteomics, metabolomics and bioinformatics of Taxus and their endophytic fungi. Systems biology and various omics technologies will play an increasingly important role in the coming decades.

  3. Interdisciplinary research and education at the biology-engineering-computer science interface: a perspective.

    Science.gov (United States)

    Tadmor, Brigitta; Tidor, Bruce

    2005-09-01

    Progress in the life sciences, including genome sequencing and high-throughput experimentation, offers an opportunity for understanding biology and medicine from a systems perspective. This 'new view', which complements the more traditional component-based approach, involves the integration of biological research with approaches from engineering disciplines and computer science. The result is more than a new set of technologies. Rather, it promises a fundamental reconceptualization of the life sciences based on the development of quantitative and predictive models to describe crucial processes. To achieve this change, learning communities are being formed at the interface of the life sciences, engineering and computer science. Through these communities, research and education will be integrated across disciplines and the challenges associated with multidisciplinary team-based science will be addressed.

  4. Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers

    International Nuclear Information System (INIS)

    Jurisson, Silvia S.; Lever, Susan Z.; Robertson, J. David

    2016-01-01

    This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with 18 F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.

  5. Protecting Traditional Knowledge Related to Biological Resources: Is Scientific Research Going to Become More Bureaucratized?

    Science.gov (United States)

    Reddy, Prashant; Lakshmikumaran, Malathi

    2015-06-22

    For the past several decades, there has been a world debate on the need for protecting traditional knowledge. A global treaty appears to be a distant reality. Of more immediate concern are the steps taken by the global community to protect access to biological resources in the name of protecting traditional knowledge. The Indian experience with implementing the Convention on Biological Diversity has created substantial legal uncertainty in collaborative scientific research between Indians and foreigners apart from bureaucratizing the entire process of scientific research, especially with regard to filing of applications for intellectual property rights. The issue therefore is whether the world needs to better balance the needs of the scientific community with the rights of those who have access to traditional knowledge. Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.

  6. Sleep as a biological problem: an overview of frontiers in sleep research.

    Science.gov (United States)

    Kanda, Takeshi; Tsujino, Natsuko; Kuramoto, Eriko; Koyama, Yoshimasa; Susaki, Etsuo A; Chikahisa, Sachiko; Funato, Hiromasa

    2016-01-01

    Sleep is a physiological process not only for the rest of the body but also for several brain functions such as mood, memory, and consciousness. Nevertheless, the nature and functions of sleep remain largely unknown due to its extremely complicated nature and lack of optimized technology for the experiments. Here we review the recent progress in the biology of the mammalian sleep, which covers a wide range of research areas: the basic knowledge about sleep, the physiology of cerebral cortex in sleeping animals, the detailed morphological features of thalamocortical networks, the mechanisms underlying fluctuating activity of autonomic nervous systems during rapid eye movement sleep, the cutting-edge technology of tissue clearing for visualization of the whole brain, the ketogenesis-mediated homeostatic regulation of sleep, and the forward genetic approach for identification of novel genes involved in sleep. We hope this multifaceted review will be helpful for researchers who are interested in the biology of sleep.

  7. Research Projects for Interrogations of Biological Systems: Training for the Development of Novel Radiotracers

    Energy Technology Data Exchange (ETDEWEB)

    Jurisson, Silvia S. [Univ. of Missouri, Columbia, MO (United States); Lever, Susan Z. [Univ. of Missouri, Columbia, MO (United States); Robertson, J. David [Univ. of Missouri, Columbia, MO (United States)

    2016-10-04

    This grant was situated at the University of Missouri to train Ph.D. scientists in radiochemistry and synthetic chemistry in conjunction with Faculty from the Interdisciplinary Plant Group, Division of Biological Sciences, the MU Research Reactor Center, Molecular Biology and the Radiopharmaceutical Sciences Institute. This project was collaborative with Brookhaven National Laboratory (Richard Ferrieri, PI). Projects for the Ph.D. candidates included novel probe development for peptides, nucleosides, small molecules or radiometals, the direct use of radiometals as probes, or nuclear techniques for analysis. The projects for the postdoctoral fellow involved synthetic chemistry for the preparation of precursors for novel tracers that will be radiolabeled with 18F or other appropriate radionuclides. The skill sets of our team members allowed us to prepare probes with positron or single photon emitters, as well as ones that are dual-labeled (fluorescent and radiolabeled). We focused our technical advances to those that will be broadly applicable to any research field.

  8. Sex as a Biological Variable in Emergency Medicine Research and Clinical Practice: A Brief Narrative Review.

    Science.gov (United States)

    McGregor, Alyson J; Beauchamp, Gillian A; Wira, Charles R; Perman, Sarah M; Safdar, Basmah

    2017-10-01

    The National Institutes of Health recently highlighted the significant role of sex as a biological variable (SABV) in research design, outcome and reproducibility, mandating that this variable be accounted for in all its funded research studies. This move has resulted in a rapidly increasing body of literature on SABV with important implications for changing the clinical practice of emergency medicine (EM). Translation of this new knowledge to the bedside requires an understanding of how sex-based research will ultimately impact patient care. We use three case-based scenarios in acute myocardial infarction, acute ischemic stroke and important considerations in pharmacologic therapy administration to highlight available data on SABV in evidence-based research to provide the EM community with an important foundation for future integration of patient sex in the delivery of emergency care as gaps in research are filled.

  9. Information Technology Research Services: Powerful Tools to Keep Up with a Rapidly Moving Field

    Science.gov (United States)

    Hunter, Paul

    2010-01-01

    Marty firms offer Information Technology Research reports, analyst calls, conferences, seminars, tools, leadership development, etc. These entities include Gartner, Forrester Research, IDC, The Burton Group, Society for Information Management, 1nfoTech Research, The Corporate Executive Board, and so on. This talk will cover how a number of such services are being used at the Goddard Space Flight Center to improve our IT management practices, workforce skills, approach to innovation, and service delivery. These tools and services are used across the workforce, from the executive leadership to the IT worker. The presentation will cover the types of services each vendor provides and their primary engagement model. The use of these services at other NASA Centers and Headquarters will be included. In addition, I will explain how two of these services are available now to the entire NASA IT workforce through enterprise-wide subscriptions.

  10. Market Research Gathering Information About Commercial Products and Services

    National Research Council Canada - National Science Library

    1997-01-01

    DoD 5000.2-R, Mandatory Procedures for Major Defense Acquisition Programs and Major Automated Information System Acquisition Programs, requires that market research and analysis be conducted to determine...

  11. Scientific works of research workers of the army health service

    International Nuclear Information System (INIS)

    1994-01-01

    Ten articles about the effects of gamma radiation or neutron radiation on human or animal cells are studied here. Effects of radiation, recoveries, research on radioprotective substances are examined in these articles. (N.C.)

  12. Research in the service of modern macroeconomic analysis

    Directory of Open Access Journals (Sweden)

    Pantelić Svetlana

    2014-01-01

    Full Text Available Thomas Sargent and Christopher Sims, American professors, conducted independent scientific researches back in the 1970s and 1980s, yet the explanation of the 2011 Nobel Prize Committee of the Royal Swedish Academy states that the methods they developed are among the crucial tools in today's macroeconomic analysis. More precisely, they were awarded for their empirical research on cause and effect in macroeconomics.

  13. Spectroscopic research of interaction between pulsed laser radiation and some biological objects

    Science.gov (United States)

    Loschenov, Victor B.; Betin, A. J.; Volkova, Anna I.; Konov, Vitali I.; Kramarenko, T. A.; Silenok, Alexander S.

    1990-09-01

    This research is dedicated to spectral analysis methods of i&raction of high enerciy laser radiation with biological objects like humain vessel affected by atheroscie rosis (investigated immediately after its surgical removal) and gallstones of diffe rent kinds. In our work ie used laser sources jithA3fl8 nm (Eximer laser Xe-Cl), A532 nm andlO64 nm ( YAG:Nd3).

  14. SYNBIOCHEM Synthetic Biology Research Centre, Manchester – A UK foundry for fine and speciality chemicals production

    Directory of Open Access Journals (Sweden)

    Le Feuvre RA

    2016-12-01

    Full Text Available The UK Synthetic Biology Research Centre, SYNBIOCHEM, hosted by the Manchester Institute of Biotechnology at the University of Manchester is delivering innovative technology platforms to facilitate the predictable engineering of microbial bio-factories for fine and speciality chemicals production. We provide an overview of our foundry activities that are being applied to grand challenge projects to deliver innovation in bio-based chemicals production for industrial biotechnology.

  15. Human embryonic stem cell research, justice, and the problem of unequal biological access

    Directory of Open Access Journals (Sweden)

    Moller Mark S

    2008-09-01

    Full Text Available Abstract In 2003, Ruth Faden and eighteen other colleagues argued that a "problem of unequal biological access" is likely to arise in access to therapies resulting from human embryonic stem cell research. They showed that unless deliberate steps are taken in the United States to ensure that the human embryonic stem cell lines available to researchers mirrors the genetic diversity of the general population, white Americans will likely receive the benefits of these therapies to the relative exclusion of minority ethnic groups. Over the past five years the problem of unequal biological access has not received much attention from politicians, bioethicists and even many researchers in the United States, in spite of the widely held belief in the country that there is an obligation to prevent and correct ethnic disparities in access to medical care. The purpose of this paper is to increase awareness of the problem of unequal biological access and of the need to do more than is currently being done to ensure that ethnic disparities in access to human embryonic stem cell-based therapies do not arise. Specifically, this paper explains why the problem of unequal biological access will likely arise in the United States in such a way that white Americans will disproportionately receive most of the benefits of the therapies resulting from human embryonic stem cell research. It also argues for why there is an obligation to prevent these ethnic disparities in access from happening and outlines four steps that need to be taken towards meeting this obligation.

  16. A Vital Legacy: Biological and Environmental Research in the Atomic Age

    Science.gov (United States)

    1997-09-01

    This booklet presents a summary of the five decades of biological and environmental research in the atomic age. It commemorates the contributions to science and society during these decades and concludes with a view to the years ahead. The Contents includes Safety First: in the Shadow of a New Technology; A Healthy Citizenry: Gifts of the New Era; and Environmental Concerns: From Meteorology to Ecology. The conclusion is titled An Enduring Mandate: Looking to the Future.

  17. A vital legacy: Biological and environmental research in the atomic age

    Energy Technology Data Exchange (ETDEWEB)

    Vaughan, D. [ed.

    1997-09-01

    This booklet presents a summary of the five decades of biological and environmental research in the atomic age. It commemorates the contributions to science and society during these decades and concludes with a view to the years ahead. The Contents includes `Safety First: in the Shadow of a New Technology; A Healthy Citizenry: Gifts of the New Era; and Environmental Concerns: From Meteorology to Ecology`. The conclusion is titled `An Enduring Mandate: Looking to the Future`.

  18. Ecosystem services and economic theory: integration for policy-relevant research.

    Science.gov (United States)

    Fisher, Brendan; Turner, Kerry; Zylstra, Matthew; Brouwer, Roy; de Groot, Rudolf; Farber, Stephen; Ferraro, Paul; Green, Rhys; Hadley, David; Harlow, Julian; Jefferiss, Paul; Kirkby, Chris; Morling, Paul; Mowatt, Shaun; Naidoo, Robin; Paavola, Jouni; Strassburg, Bernardo; Yu, Doug; Balmford, Andrew

    2008-12-01

    It has become essential in policy and decision-making circles to think about the economic benefits (in addition to moral and scientific motivations) humans derive from well-functioning ecosystems. The concept of ecosystem services has been developed to address this link between ecosystems and human welfare. Since policy decisions are often evaluated through cost-benefit assessments, an economic analysis can help make ecosystem service research operational. In this paper we provide some simple economic analyses to discuss key concepts involved in formalizing ecosystem service research. These include the distinction between services and benefits, understanding the importance of marginal ecosystem changes, formalizing the idea of a safe minimum standard for ecosystem service provision, and discussing how to capture the public benefits of ecosystem services. We discuss how the integration of economic concepts and ecosystem services can provide policy and decision makers with a fuller spectrum of information for making conservation-conversion trade-offs. We include the results from a survey of the literature and a questionnaire of researchers regarding how ecosystem service research can be integrated into the policy process. We feel this discussion of economic concepts will be a practical aid for ecosystem service research to become more immediately policy relevant.

  19. Cultural Ecosystem Services: A Literature Review and Prospects for Future Research

    Directory of Open Access Journals (Sweden)

    Andra Ioana. Milcu

    2013-09-01

    Full Text Available Cultural ecosystem services constitute a growing field of research that is characterized by an increasing number of publications from various academic disciplines. We conducted a semiquantitative review of publications explicitly dealing with cultural ecosystem services. Our aims were: (1 to provide an overview of the current state of research, (2 to classify the diversity of research approaches by identifying clusters of publications that address cultural ecosystem services in similar ways, and (3 to highlight some important challenges for the future of cultural ecosystem services research. We reviewed 107 publications and extracted 20 attributes describing their type and content, including methods, scales, drivers of change, and trade-offs between services. Using a cluster analysis on a subset of attributes we identified five groups of publications: Group 1, conceptual focus, deals with theoretical issues; Group 2, descriptive reviews, consists mostly of desktop studies; Group 3, localized outcomes, deals with case studies coming from different disciplines; Group 4, social and participatory, deals mainly with assessing preferences and perceptions; and Group 5, economic assessments, provides economic valuations. Emerging themes in cultural ecosystem services research relate to improving methods for cultural ecosystem services valuation, studying cultural ecosystem services in the context of ecosystem service bundles, and more clearly articulating policy implications. Based on our findings, we conclude that: (1 cultural ecosystem services are well placed as a tool to bridge gaps between different academic disciplines and research communities, (2 capitalizing on the societal relevance of cultural ecosystem services could help address real-world problems, and (3 cultural ecosystem services have the potential to foster new conceptual links between alternative logics relating to a variety of social and ecological issues.

  20. Using a Popular Science Nonfiction Book to Introduce Biomedical Research Ethics in a Biology Majors Course

    Directory of Open Access Journals (Sweden)

    Kristen L.W. Walton

    2014-08-01

    Full Text Available Although bioethics is an important topic in modern society, it is not a required part of the curriculum for many biology degree programs in the United States.  Students in our program are exposed to biologically relevant ethical issues informally in many classes, but we do not have a requirement for a separate bioethics course.  The Immortal Life of Henrietta Lacks is a recent nonfiction book that describes the life of the woman whose cervical cancer biopsy gave rise to the HeLa cell line, as well as discussing relevant medical, societal, and ethical issues surrounding human tissue use for research.  Weekly reading assignments from the book with discussion questions and a final paper were used to engage students in learning about the ethics of human subjects and human tissues research.  Students were surveyed for qualitative feedback on the usefulness of including this book as part of the course.  This book has been a successful platform for increasing student knowledge and interest in ethics related to biomedical and biological research.

  1. Using a popular science nonfiction book to introduce biomedical research ethics in a biology majors course.

    Science.gov (United States)

    Walton, Kristen L W

    2014-12-01

    Although bioethics is an important topic in modern society, it is not a required part of the curriculum for many biology degree programs in the United States. Students in our program are exposed to biologically relevant ethical issues informally in many classes, but we do not have a requirement for a separate bioethics course. The Immortal Life of Henrietta Lacks is a recent nonfiction book that describes the life of the woman whose cervical cancer biopsy gave rise to the HeLa cell line, as well as discussing relevant medical, societal, and ethical issues surrounding human tissue use for research. Weekly reading assignments from the book with discussion questions and a final paper were used to engage students in learning about the ethics of human subjects and human tissues research. Students were surveyed for qualitative feedback on the usefulness of including this book as part of the course. This book has been a successful platform for increasing student knowledge and interest in ethics related to biomedical and biological research.

  2. Research Status on Equalization of Public Sports Service for Nationwide Fitness in Hebei

    Science.gov (United States)

    Cui, Ruixue; Su, lina

    Public physical service equalization is a general term of all kinds of sports activity and service which are provided for satisfying the public demand of public sports. It has become social focus that how to meet the people's needs in all aspects based on "people-oriented" and make public sports service equal access to everyone. This article proposed several ways to ensure all citizens' equal right to share national fitness public sports service though research of equal access to public sports fitness in Hebei province, like changing and strengthening the public service function of sports departments, establishing the basic contents and service standards of public sports fitness, coordination of urban and rural and regional public sports fitness service development, strengthening the construction of sports organizations and perfecting specific operation mechanism. It needs processes to realize the target of public sports service equalization gradually.

  3. Shaping scientific attitude of biology education students through research-based teaching

    Science.gov (United States)

    Firdaus, Darmadi

    2017-08-01

    Scientific attitude is need of today's society for peaceful and meaningful living of every person in a multicultural world. A case study was conducted at the Faculty of Teacher Training and Education, University of Riau, Pekanbaru in order to describe the scientific attitude that shaped by research-based teaching (RBT). Eighteen students of English for Biology bilingual program were selected from 88 regular students as a subject of the study. RBT designed consists of 9 steps: 1) field observations, 2) developing research proposals, 3) research proposal seminar, 4) field data collecting, 5) data analyzing & ilustrating, 6) writing research papers, 7) preparing power point slides, 8) creating a scientific poster, 9) seminar & poster session. Data were collected by using check list observation instuments during 14 weeks (course sessions), then analyzed by using descriptive-quantitative method. The results showed that RBT were able to shape critical-mindedness, suspended judgement, respect for evidence, honesty, objectivity, and questioning attitude as well as tolerance of uncertainty. These attitudes which shaped were varies according to every steps of learning activities. It's seems that the preparation of scientific posters and research seminar quite good in shaping the critical-mindedness, suspended judgment, respect for evidence, honesty, objectivity, and questioning attitude, as well as tolerance of uncertainty. In conclusion, the application of research-based teaching through the English for Biology courses could shape the students scientific attitudes. However, the consistency of the appearance of a scientific attitude in every stage of Biology-based RBT learning process need more intensive and critical assessment.

  4. A Comparative Study of Compression Methods and the Development of CODEC Program of Biological Signal for Emergency Telemedicine Service

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, T.S.; Kim, J.S. [Changwon National University, Changwon (Korea); Lim, Y.H. [Visionite Co., Ltd., Seoul (Korea); Yoo, S.K. [Yonsei University, Seoul (Korea)

    2003-05-01

    In an emergency telemedicine system such as the High-quality Multimedia based Real-time Emergency Telemedicine(HMRET) service, it is very important to examine the status of the patient continuously using the multimedia data including the biological signals(ECG, BP, Respiration, S{sub p}O{sub 2}) of the patient. In order to transmit these data real time through the communication means which have the limited transmission capacity, it is also necessary to compress the biological data besides other multimedia data. For this purpose, we investigate and compare the ECG compression techniques in the time domain and in the wavelet transform domain, and present an effective lossless compression method of the biological signals using JPEG Huffman table for an emergency telemedicine system. And, for the HMRET service, we developed the lossless compression and reconstruction program of the biological signals in MSVC++ 6.0 using DPCM method and JPEG Huffman table, and tested in an internet environment. (author). 15 refs., 17 figs., 7 tabs.

  5. NATO Advanced Research Workshop on Fluorescence and other Optical Properties of Biological Particles for Biological Warfare Agent Sensors

    CERN Document Server

    Hoekstra, Alfons; Videen, Gorden; Optics of Biological Particles

    2007-01-01

    This book covers the optics of single biological particles, both theory and experiment, with emphasis on Elastic Light Scattering and Fluorescence. It deals with the optics of bacteria (bio-aerosols), marine particles (selected phytoplankton communities) and red and white blood cells. Moreover, there are dedicated chapters on a general theory for scattering by a cell, and modelling and simulation of scattering by inhomogeneous biological cells. Finally, one chapter is dedicated to astro-biological signatures, discussing the possibilities for detecting non-terrestrial biological material. The volume has up-to-date discussions on new experimental and numerical techniques, and many examples of applications of these techniques in real-life systems, as used to detect and characterize e.g. biological warfare agents or human blood cells.

  6. Space Biology Model Organism Research on the Deep Space Gateway to Pioneer Discovery and Advance Human Space Exploration

    Science.gov (United States)

    Sato, K. Y.; Tomko, D. L.; Levine, H. G.; Quincy, C. D.; Rayl, N. A.; Sowa, M. B.; Taylor, E. M.; Sun, S. C.; Kundrot, C. E.

    2018-02-01

    Model organisms are foundational for conducting physiological and systems biology research to define how life responds to the deep space environment. The organisms, areas of research, and Deep Space Gateway capabilities needed will be presented.

  7. Biological Visualization, Imaging and Simulation(Bio-VIS) at NASA Ames Research Center: Developing New Software and Technology for Astronaut Training and Biology Research in Space

    Science.gov (United States)

    Smith, Jeffrey

    2003-01-01

    The Bio- Visualization, Imaging and Simulation (BioVIS) Technology Center at NASA's Ames Research Center is dedicated to developing and applying advanced visualization, computation and simulation technologies to support NASA Space Life Sciences research and the objectives of the Fundamental Biology Program. Research ranges from high resolution 3D cell imaging and structure analysis, virtual environment simulation of fine sensory-motor tasks, computational neuroscience and biophysics to biomedical/clinical applications. Computer simulation research focuses on the development of advanced computational tools for astronaut training and education. Virtual Reality (VR) and Virtual Environment (VE) simulation systems have become important training tools in many fields from flight simulation to, more recently, surgical simulation. The type and quality of training provided by these computer-based tools ranges widely, but the value of real-time VE computer simulation as a method of preparing individuals for real-world tasks is well established. Astronauts routinely use VE systems for various training tasks, including Space Shuttle landings, robot arm manipulations and extravehicular activities (space walks). Currently, there are no VE systems to train astronauts for basic and applied research experiments which are an important part of many missions. The Virtual Glovebox (VGX) is a prototype VE system for real-time physically-based simulation of the Life Sciences Glovebox where astronauts will perform many complex tasks supporting research experiments aboard the International Space Station. The VGX consists of a physical display system utilizing duel LCD projectors and circular polarization to produce a desktop-sized 3D virtual workspace. Physically-based modeling tools (Arachi Inc.) provide real-time collision detection, rigid body dynamics, physical properties and force-based controls for objects. The human-computer interface consists of two magnetic tracking devices

  8. International Trends in Biology Education Research from 1997 to 2014: A Content Analysis of Papers in Selected Journals

    Science.gov (United States)

    Gul, Seyda; Sozbilir, Mustafa

    2016-01-01

    This paper provides a descriptive content analysis of biology education research papers published in eight major academic journals indexed in Social Science Citation Index [SSCI] of Thomson Reuters® from 1997 to 2014. Total of 1376 biology education research [BER] papers were examined. The findings indicated that most of the papers were published…

  9. Product-services as a research field: past, present and future. Reflections from a decade of research

    NARCIS (Netherlands)

    Tukker, A.; Tischner, U.

    2006-01-01

    In the last decade many researchers, institutes and programs in the EU paid attention to product-service systems (PSS). Given this massive effort, it is time to take stock. Is PSS research a theoretical field in its own right? Is the PSS concept indeed the road to the Factor 10 world? Is it the road

  10. Fedora Content Modelling for Improved Services for Research Databases

    DEFF Research Database (Denmark)

    Elbæk, Mikael Karstensen; Heller, Alfred; Pedersen, Gert Schmeltz

    A re-implementation of the research database of the Technical University of Denmark, DTU, is based on Fedora. The backbone consists of content models for primary and secondary entities and their relationships, giving flexible and powerful extraction capabilities for interoperability and reporting...

  11. Directions in healthcare research: Pointers from retailing and services marketing

    NARCIS (Netherlands)

    van Rompay, Thomas Johannes Lucas; Dijkstra, K.

    2010-01-01

    Purpose: Although the importance of the environment in relation to healing processes has been well established, empirical evidence for environmental effects on patient well-being and behavior is sparse. In addition, few attempts have been made to integrate insights from related fields of research

  12. Action Research Projects in Pre-Service Teacher Education

    Science.gov (United States)

    Clayton, Courtney; Meadows, George

    2013-01-01

    Classroom-centered Action Research Projects are an integral component of the M.S. in Elementary Education Program at the University's (pseudonym) College of Education. This article provides a summary and discussion of the projects completed by students in the Science, Technology, Literacy and English Language Learner Specializations of the…

  13. Directions in healthcare research : Pointers from retailing and services marketing

    NARCIS (Netherlands)

    Van Rompay, Thomas J L; Tanja-Dijkstra, Karin

    Purpose: Although the importance of the environment in relation to healing processes has been well established, empirical evidence for environmental effects on patient well-being and behavior is sparse. In addition, few attempts have been made to integrate insights from related fields of research

  14. Biological Course-Based Undergraduate Research Experiences: An Examination of an Introductory Level Implementation

    Science.gov (United States)

    Knoth, Kenneth Charles

    Course-based undergraduate research experiences (CUREs) provide authentic research benefits to an entire laboratory course population. CURE experiences are proposed to enhance research skills, critical thinking, productivity, and retention in science. CURE curriculum developers face numerous obstacles, such as the logistics and time commitment involved in bringing a CURE to larger student populations. In addition, an ideal CURE topic requires affordable resources, lab techniques that can be quickly mastered, time for multiple iterations within one semester, and the opportunity to generate new data. This study identifies some of the CURE activities that lead to proposed participant outcomes. Introductory Biology I CURE lab students at Southern Illinois University Edwardsville completed research related to the process of converting storage lipids in microalgae into biodiesel. Data collected from CURE and traditional lab student participants indicate increased CURE student reports of project ownership, scientific self-efficacy, identification as a scientist, and sense of belonging to a science community. Study limitations and unanticipated benefits are discussed.

  15. Current trends and new challenges of databases and web applications for systems driven biological research

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar eSreenivasaiah

    2010-12-01

    Full Text Available Dynamic and rapidly evolving nature of systems driven research imposes special requirements on the technology, approach, design and architecture of computational infrastructure including database and web application. Several solutions have been proposed to meet the expectations and novel methods have been developed to address the persisting problems of data integration. It is important for researchers to understand different technologies and approaches. Having familiarized with the pros and cons of the existing technologies, researchers can exploit its capabilities to the maximum potential for integrating data. In this review we discuss the architecture, design and key technologies underlying some of the prominent databases (DBs and web applications. We will mention their roles in integration of biological data and investigate some of the emerging design concepts and computational technologies that are likely to have a key role in the future of systems driven biomedical research.

  16. Practicing the triad teaching-research- extension in supervised internship of licentiateship in biological sciences

    Directory of Open Access Journals (Sweden)

    Lilliane Miranda Freitas

    2012-06-01

    Full Text Available In this paper we report an educational experience based on the triad teaching-research-extension occurred in the supervised internship in licentiateship in Biological Sciences. In this experiment, the students made a transposition of the scientific knowledge produced in their course conclusion work to the knowledge of basic education curriculum. We analyze in this article the impressions of undergraduates after completion of pedagogical actions. We discuss, based on the reports, how the knowledge that is constructed and reconstructed in academic research can contribute directly to the improvement of the science education quality through science literacy and also in teacher training of undergraduates, through the reflection on their own practice. Therefore, we consider that, with the practice of the inseparability of teaching-research-extension, there will be more return for academic research and also for the school community, generating significant changes in educational practices in schools

  17. ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus.

    Directory of Open Access Journals (Sweden)

    Peter D. Karp

    2015-01-01

    Full Text Available Speed is of the essence in combating Ebola; thus, computational approaches should form a significant component of Ebola research. As for the development of any modern drug, computational biology is uniquely positioned to contribute through comparative analysis of the genome sequences of Ebola strains as well as 3-D protein modeling. Other computational approaches to Ebola may include large-scale docking studies of Ebola proteins with human proteins and with small-molecule libraries, computational modeling of the spread of the virus, computational mining of the Ebola literature, and creation of a curated Ebola database. Taken together, such computational efforts could significantly accelerate traditional scientific approaches. In recognition of the need for important and immediate solutions from the field of computational biology against Ebola, the International Society for Computational Biology (ISCB announces a prize for an important computational advance in fighting the Ebola virus. ISCB will confer the ISCB Fight against Ebola Award, along with a prize of US$2,000, at its July 2016 annual meeting (ISCB Intelligent Systems for Molecular Biology [ISMB] 2016, Orlando, Florida.

  18. A 2-1-1 research collaboration: participant accrual and service quality indicators.

    Science.gov (United States)

    Eddens, Katherine S; Alcaraz, Kassandra I; Kreuter, Matthew W; Rath, Suchitra; Greer, Regina

    2012-12-01

    In times of crises, 2-1-1 serves as a lifeline in many ways. These crises often cause a spike in call volume that can challenge 2-1-1's ability to meet its service quality standards. For researchers gathering data through 2-1-1s, a sudden increase in call volume might reduce accrual as 2-1-1 has less time to administer study protocols. Research activities imbedded in 2-1-1 systems may affect directly 2-1-1 service quality indicators. Using data from a 2-1-1 research collaboration, this paper examines the impact of crises on call volume to 2-1-1, how call volume affects research participant accrual through 2-1-1, and how research recruitment efforts affect 2-1-1 service quality indicators. t-tests were used to examine the effect of call volume on research participant accrual. Linear and logistic regressions were used to examine the effect of research participant accrual on 2-1-1 service quality indicators. Data were collected June 2010-December 2011; data were analyzed in 2012. Findings from this collaboration suggest that crises causing spikes in call volume adversely affect 2-1-1 service quality indicators as well as accrual of research participants. Administering a brief (2-3 minute) health risk assessment did not affect service quality negatively, but administering a longer (15-18 minute) survey had a modest adverse effect on these indicators. In 2-1-1 research collaborations, both partners need to understand the dynamic relationship among call volume, research accrual, and service quality and adjust expectations accordingly. If research goals include administering a longer survey, increased staffing of 2-1-1 call centers may be needed to avoid compromising service quality. Copyright © 2012 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

  19. Experiences of mobility for people living with rheumatoid arthritis who are receiving biologic drug therapy: implications for podiatry services.

    Science.gov (United States)

    Sanders, Lucy; Donovan-Hall, Margaret; Borthwick, Alan; Bowen, Catherine J

    2017-01-01

    problematic access to foot health services. Whilst the findings from this study mirror those within the existing literature, which report improvements in physical function related to biological therapy, foot problems clearly remained an unremitting feature of life for patients with rheumatoid disease, even when in receipt of biologics.

  20. Research into the influence of internal interdepartmental integration on service innovation and customer loyalty

    Science.gov (United States)

    Huang, Jui-Chan; Wu, Tzu-Jung; Wen, Hao-Ming; Hsin-Fei, Wu; Hairui, Ji

    2017-06-01

    It is the most important for the company to improve customer value and customer loyalty through service innovation. However, at present, only researches related to organizations or consumer behaviors are conducted, there is rare research into the combination between organization level and consumer behavior, and this research tries to explore this aspect, which is the motivation and contribution of this research. This research aims to explore the relationship between "Interdepartmental Integration", "Service Innovation" and "Customer Loyalty", according to the analysis results, the relationship between "interdepartmental integration and service innovation" and "service innovation and customer loyalty" has a low positive correlation and it reaches significant level; it shows the relationship between "interdepartmental interaction and progressive innovation" and "interdepartmental collaboration and fundamental innovation" is significant.

  1. Community-Based Participatory Research Integrates Behavioral and Biological Research to Achieve Health Equity for Native Hawaiians

    Science.gov (United States)

    Townsend, Claire K. M.; Dillard, Adrienne; Hosoda, Kelsea K.; Maskarinec, Gregory G.; Maunakea, Alika K.; Yoshimura, Sheryl R.; Hughes, Claire; Palakiko, Donna-Marie; Kehauoha, Bridget Puni; Kaholokula, Joseph Keawe‘aimoku

    2015-01-01

    Native Hawaiians bear a disproportionate burden of type-2 diabetes and related complications compared to all other groups in Hawai‘i (e.g., Whites, Japanese, Korean). Distrust in these communities is a significant barrier to participation in epigenetic research studies seeking to better understand disease processes. The purpose of this paper is to describe the community-based participatory research (CBPR) approach and research process we employed to integrate behavior and biological sciences with community health priorities. A CBPR approach was used to test a 3-month evidence-based, diabetes self-management intervention (N = 65). To investigate the molecular mechanisms linking inflammation with glucose homeostasis, a subset of participants (n = 16) provided peripheral blood mononuclear cells. Community and academic researchers collaborated on research design, assessment protocols, and participant recruitment, prioritizing participants’ convenience and education and strictly limiting the use of the data collected. Preliminary results indicate significant changes in DNA methylation at gene regions associated with inflammation and diabetes signaling pathways and significant improvements in hemoglobin A1c, self-care activities, and diabetes distress and understanding. This study integrates community, behavioral, and epigenomic expertise to better understand the outcomes of a diabetes self-management intervention. Key lessons learned suggest the studies requiring biospecimen collection in indigenous populations require community trust of the researchers, mutual benefits for the community and researchers, and for the researchers to prioritize the community’s needs. CBPR may be an important tool in providing communities the voice and protections to participate in studies requiring biospecimens. PMID:26703660

  2. Community-Based Participatory Research Integrates Behavioral and Biological Research to Achieve Health Equity for Native Hawaiians

    Directory of Open Access Journals (Sweden)

    Claire K. M. Townsend

    2015-12-01

    Full Text Available Native Hawaiians bear a disproportionate burden of type-2 diabetes and related complications compared to all other groups in Hawai‘i (e.g., Whites, Japanese, Korean. Distrust in these communities is a significant barrier to participation in epigenetic research studies seeking to better understand disease processes. The purpose of this paper is to describe the community-based participatory research (CBPR approach and research process we employed to integrate behavior and biological sciences with community health priorities. A CBPR approach was used to test a 3-month evidence-based, diabetes self-management intervention (N = 65. To investigate the molecular mechanisms linking inflammation with glucose homeostasis, a subset of participants (n = 16 provided peripheral blood mononuclear cells. Community and academic researchers collaborated on research design, assessment protocols, and participant recruitment, prioritizing participants’ convenience and education and strictly limiting the use of the data collected. Preliminary results indicate significant changes in DNA methylation at gene regions associated with inflammation and diabetes signaling pathways and significant improvements in hemoglobin A1c, self-care activities, and diabetes distress and understanding. This study integrates community, behavioral, and epigenomic expertise to better understand the outcomes of a diabetes self-management intervention. Key lessons learned suggest the studies requiring biospecimen collection in indigenous populations require community trust of the researchers, mutual benefits for the community and researchers, and for the researchers to prioritize the community’s needs. CBPR may be an important tool in providing communities the voice and protections to participate in studies requiring biospecimens.

  3. Clever generation of rich SPARQL queries from annotated relational schema: application to Semantic Web Service creation for biological databases.

    Science.gov (United States)

    Wollbrett, Julien; Larmande, Pierre; de Lamotte, Frédéric; Ruiz, Manuel

    2013-04-15

    In recent years, a large amount of "-omics" data have been produced. However, these data are stored in many different species-specific databases that are managed by different institutes and laboratories. Biologists often need to find and assemble data from disparate sources to perform certain analyses. Searching for these data and assembling them is a time-consuming task. The Semantic Web helps to facilitate interoperability across databases. A common approach involves the development of wrapper systems that map a relational database schema onto existing domain ontologies. However, few attempts have been made to automate the creation of such wrappers. We developed a framework, named BioSemantic, for the creation of Semantic Web Services that are applicable to relational biological databases. This framework makes use of both Semantic Web and Web Services technologies and can be divided into two main parts: (i) the generation and semi-automatic annotation of an RDF view; and (ii) the automatic generation of SPARQL queries and their integration into Semantic Web Services backbones. We have used our framework to integrate genomic data from different plant databases. BioSemantic is a framework that was designed to speed integration of relational databases. We present how it can be used to speed the development of Semantic Web Services for existing relational biological databases. Currently, it creates and annotates RDF views that enable the automatic generation of SPARQL queries. Web Services are also created and deployed automatically, and the semantic annotations of our Web Services are added automatically using SAWSDL attributes. BioSemantic is downloadable at http://southgreen.cirad.fr/?q=content/Biosemantic.

  4. A Survey of Conceptions of Energy of Israeli Pre-Service High School Biology Teachers.

    Science.gov (United States)

    Trumper, Ricardo

    1997-01-01

    Identifies the conceptions of energy of preservice high school biology teachers. Findings indicate that this group of preservice teachers holds alternate conceptual frameworks when describing physical situations. Contains 35 references. (DDR)

  5. User services in the central library of Juelich Research Center

    International Nuclear Information System (INIS)

    Lapp, E.

    1993-01-01

    The central library is a sci/tech special library providing information for the KFA researchers and staff. The library has a large collection of sci/tech materials to meet the information demands of the KFA employees and over 3.000 external users. Among the outside users are students fromthe universities and polytechnics of the region Aachen, Cologne, Duesseldorf, and industry. The library acquires about 8.000 volumes per year and subscribes to 2000 journals. (orig.)

  6. CEGB research on boiler leaks and their detection in service

    International Nuclear Information System (INIS)

    Hayes, D.J.

    1978-01-01

    The penalty in loss of output to an electricity generation organisation as a consequence of failure to deal effectively with small LMFBR boiler leaks would be large. There is therefore a considerable incentive for these organisations to satisfy themselves that proper provisions are made to ensure that both the incidence and the severity of boiler leaks are minimised. In the UK, responsibility for the research, development and design work for this and indeed for most aspects of future nuclear power plant rests with the UKAEA and NPC; nevertheless as a consequence of its 'informed operator' policy the Central Electricity Generating Board has devoted some research effort to this field in recent years. o date, research work has been put in hand with the objective of achieving an understanding of the basic behaviour of boiler leaks. In addition, attention has been given to leak detection by monitoring the sodium for increases in oxygen and hydrogen levels. In both cases leaks into liquid sodium rather than into the gas space have been considered. In the course of the work hydrogen and oxygen meters based on the galvanic cell principle have been constructed and evaluated. The former is a new device which is comparable in performance with hydrogen meters based on the ion pump. The present state of the work is briefly described in this paper

  7. Seed Biology Updates - Highlights and New Discoveries in Seed Dormancy and Germination Research.

    Science.gov (United States)

    Nonogaki, Hiroyuki

    2017-01-01

    An understanding of the biology of seeds has been greatly advanced in recent years. The progresses, particularly in the field of seed dormancy and germination research, have been made at a remarkable speed. Some of the possible epigenetic mechanisms, including an involvement of non-coding RNA, which were predicted for DELAY OF GERMINATION1 just a few years ago, have now been demonstrated with strong molecular and genetic evidence. Imprinting, or parent-of-origin-specific gene silencing/expression, which was characterized particularly for developing seeds, was also found in imbibed seeds and suggested for dormancy mechanisms. Hormone biology in seeds, which is the most advanced and almost a traditional area of seed research, also presents a new dimension. Upstream regulators of hormone metabolism and hormone transporters, such as abscisic acid and gibberellin influx/efflux carriers, have been identified. Characterization of the novel posttranslational modification pathways, including the N-end rule and S -nitrosylation pathways, which play a critical role in turnover of the major hormone signal transduction proteins, also expanded our knowledge about the complexity of hormone signaling in seeds. These progresses made at the molecular level are significant steps toward a better understanding of how seeds translate soil and other environmental signals into their internal hormone biology and make an important decision to stay dormant or commence with germination.

  8. Childhood exposure to violence and lifelong health: Clinical intervention science and stress biology research join forces

    Science.gov (United States)

    Moffitt, Terrie E.

    2013-01-01

    Many young people who are mistreated by an adult, victimized by bullies, criminally assaulted, or who witness domestic violence react to this violence exposure by developing behavioral, emotional, or learning problems. What is less well known is that adverse experiences like violence exposure can lead to hidden physical alterations inside a child’s body, alterations which may have adverse effects on life-long health. We discuss why this is important for the field of developmental psychopathology and for society, and we recommend that stress-biology research and intervention science join forces to tackle the problem. We examine the evidence base in relation to stress-sensitive measures for the body (inflammatory reactions, telomere erosion, epigenetic methylation, and gene expression) and brain (mental disorders, neuroimaging, and neuropsychological testing). We also review promising interventions for families, couples, and children that have been designed to reduce the effects of childhood violence exposure. We invite intervention scientists and stress-biology researchers to collaborate in adding stress-biology measures to randomized clinical trials of interventions intended to reduce effects of violence exposure and other traumas on young people. PMID:24342859

  9. 2010 CELL AND MOLECULAR FUNGAL BIOLOGY GORDON RESEARCH CONFERENCE, JUNE 13-18, 2010

    Energy Technology Data Exchange (ETDEWEB)

    Michelle Momany

    2010-06-18

    The Cellular and Molecular Fungal Biology Conference provides a forum for presentation of the latest advances in fungal research with an emphasis on filamentous fungi. This open-registration scientific meeting brings together the leading scientists from academia, government and industry to discuss current research results and future directions at Holderness School, an outstanding venue for scientific interaction. A key objective of the conference is to foster interaction among scientists working on model fungi such as Saccharomyces cerevisiae, Schizosaccharomyces pombe, Neurospora crassa and Aspergillus nidulans and scientists working on a variety of filamentous fungi whose laboratory tractability is often inversely proportional to their medical, industrial or ecological importance. Sessions will be devoted to Systems Biology, Fungi and Cellulosic Biomass, Small RNAs, Population Genomics, Symbioses, Pathogenesis, Membrane Trafficking and Polarity, and Cytoskeleton and Motors. A session will also be devoted to hot topics picked from abstracts. The CMFB conference provides a unique opportunity to examine the breadth of fungal biology in a small meeting format that encourages in-depth discussion among the attendees.

  10. Involving mental health service users in suicide-related research: a qualitative inquiry model.

    Science.gov (United States)

    Lees, David; Procter, Nicholas; Fassett, Denise; Handley, Christine

    2016-03-01

    To describe the research model developed and successfully deployed as part of a multi-method qualitative study investigating suicidal service-users' experiences of mental health nursing care. Quality mental health care is essential to limiting the occurrence and burden of suicide, however there is a lack of relevant research informing practice in this context. Research utilising first-person accounts of suicidality is of particular importance to expanding the existing evidence base. However, conducting ethical research to support this imperative is challenging. The model discussed here illustrates specific and more generally applicable principles for qualitative research regarding sensitive topics and involving potentially vulnerable service-users. Researching into mental health service users with first-person experience of suicidality requires stakeholder and institutional support, researcher competency, and participant recruitment, consent, confidentiality, support and protection. Research with service users into their experiences of sensitive issues such as suicidality can result in rich and valuable data, and may also provide positive experiences of collaboration and inclusivity. If challenges are not met, objectification and marginalisation of service-users may be reinforced, and limitations in the evidence base and service provision may be perpetuated.

  11. Multi-Service Doctrine for Chemical, Biological, Radiological, and Nuclear Operations

    Science.gov (United States)

    2011-07-01

    recognized by the state. Examples of state and nonstate actors are shown below:  State actors.  United States.  Germany.  Argentina .  Nonstate...and operating through black markets have placed nuclear materials and technology into the hands of adversaries who will attempt to threaten the United...facilities, and facilities that recycle biological materials for medical, pharmaceutical , or agricultural industries. Other Sources 1-35. Other biological

  12. Pre-Service Biology Teachers' and Primary School Students' Attitudes toward and Knowledge about Snakes

    Science.gov (United States)

    Tomazic, Iztok

    2011-01-01

    Snakes are controversial animals emblazoned by legends, but also endangered as a result of human prejudice and fear. The author investigated gender and age-related differences in attitudes to and knowledge of snakes comparing samples of school children and pre-service teachers. It was found that although pre-service teachers had better knowledge…

  13. The European Research Infrastructures of the ESFRI Roadmap in Biological and Medical Sciences: status and perspectives

    Directory of Open Access Journals (Sweden)

    Alessia Calzolari

    2014-06-01

    Full Text Available INTRODUCTION. Since 2002, the European Strategy Forum on Research Infrastructures identified the needs for Research Infrastructures (RIs in Europe in priority fields of scientific research and drafted a strategic document, the ESFRI Roadmap, defining the specific RIs essential to foster European research and economy. The Biological and Medical Sciences RIs (BMS RIs were developed thanks to the active participation of many institutions in different European member states associated to address the emerging needs in biomedicine and, among these, the Italian National Institute of Health (ISS, in virtue of its role in public health and research, has been specifically involved in the national development and implementation of three RIs: the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI, the European Advanced Translational Research Infrastructure in Medicine (EATRIS and the European Clinical Research Infrastructures Network (ECRIN. AIM. This article outlines the design and development of these RIs up to the recent achievement of the ERIC status, their importance in the Horizon 2020 programme and their societal and economic potential impact, with special attention to their development and significance in Italy. CONCLUSIONS. The ISS plays a unique role in fostering a coordinated participation of excellence Italian institutes/facilities to different European biomedical RIs, thus contributing to health innovation, healthcare optimization, and healthcare cost containment.

  14. Fluorescent Probes and Fluorescence (Microscopy Techniques — Illuminating Biological and Biomedical Research

    Directory of Open Access Journals (Sweden)

    Gregor P. C. Drummen

    2012-11-01

    Full Text Available Fluorescence, the absorption and re-emission of photons with longer wavelengths, is one of those amazing phenomena of Nature. Its discovery and utilization had, and still has, a major impact on biological and biomedical research, since it enables researchers not just to visualize normal physiological processes with high temporal and spatial resolution, to detect multiple signals concomitantly, to track single molecules in vivo, to replace radioactive assays when possible, but also to shed light on many pathobiological processes underpinning disease states, which would otherwise not be possible. Compounds that exhibit fluorescence are commonly called fluorochromes or fluorophores and one of these fluorescent molecules in particular has significantly enabled life science research to gain new insights in virtually all its sub-disciplines: Green Fluorescent Protein. Because fluorescent proteins are synthesized in vivo, integration of fluorescent detection methods into the biological system via genetic techniques now became feasible. Currently fluorescent proteins are available that virtually span the whole electromagnetic spectrum. Concomitantly, fluorescence imaging techniques were developed, and often progress in one field fueled innovation in the other. Impressively, the properties of fluorescence were utilized to develop new assays and imaging modalities, ranging from energy transfer to image molecular interactions to imaging beyond the diffraction limit with super-resolution microscopy. Here, an overview is provided of recent developments in both fluorescence imaging and fluorochrome engineering, which together constitute the “fluorescence toolbox” in life science research.

  15. Use of qualitative methods in published health services and management research: a 10-year review.

    Science.gov (United States)

    Weiner, Bryan J; Amick, Halle R; Lund, Jennifer L; Lee, Shoou-Yih Daniel; Hoff, Timothy J

    2011-02-01

    Over the past 10 years, the field of health services and management research has seen renewed interest in the use of qualitative research methods. This article examines the volume and characteristics of qualitative research articles published in nine major health services and management journals between 1998 and 2008. Qualitative research articles comprise 9% of research articles published in these journals. Although the publication rate of qualitative research articles has not kept pace with that of quantitative research articles, citation analysis suggests that qualitative research articles contribute comparably to the field's knowledge base. A wide range of policy and management topics has been examined using qualitative methods. Case study designs, interviews, and documentary sources were the most frequently used methods. Half of qualitative research articles provided little or no detail about key aspects the study's methods. Implications are discussed and recommendations are offered for promoting the publication of qualitative research.

  16. SURFdrive, a sync and share service for Dutch higher education and research

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    During the first three months of this year we have setup an Owncloud-based sync and share service for Dutch higher education and research. This service uses a SAML2-based federated login. In this presentation we will discuss the requirements, choices we have made, tests we have done, the technical setup and the experiences we have had so far not only with the software and our setup but also setting up this service.

  17. ICBEN review of research on the biological effects of noise 2011-2014.

    Science.gov (United States)

    Basner, Mathias; Brink, Mark; Bristow, Abigail; de Kluizenaar, Yvonne; Finegold, Lawrence; Hong, Jiyoung; Janssen, Sabine A; Klaeboe, Ronny; Leroux, Tony; Liebl, Andreas; Matsui, Toshihito; Schwela, Dieter; Sliwinska-Kowalska, Mariola; Sörqvist, Patrik

    2015-01-01

    The mandate of the International Commission on Biological Effects of Noise (ICBEN) is to promote a high level of scientific research concerning all aspects of noise-induced effects on human beings and animals. In this review, ICBEN team chairs and co-chairs summarize relevant findings, publications, developments, and policies related to the biological effects of noise, with a focus on the period 2011-2014 and for the following topics: Noise-induced hearing loss; nonauditory effects of noise; effects of noise on performance and behavior; effects of noise on sleep; community response to noise; and interactions with other agents and contextual factors. Occupational settings and transport have been identified as the most prominent sources of noise that affect health. These reviews demonstrate that noise is a prevalent and often underestimated threat for both auditory and nonauditory health and that strategies for the prevention of noise and its associated negative health consequences are needed to promote public health.

  18. Plant Molecular Biology 2008 Gordon Research Conference - July 13-18, 2008

    Energy Technology Data Exchange (ETDEWEB)

    Richard M. Amasino

    2009-08-28

    The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2008 conference will continue in that tradition. There will be sessions on metabolism; new methods to study genomes, proteomes and metabolomes; plant-microbe interactions; plant hormones; epigenetics. A new topic for the conference this year will be bioenergy. Thus this conference will bring together a range of disciplines to foster the exchange ideas and to permit the participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides an excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner.

  19. ICBEN review of research on the biological effects of noise 2011-2014

    Directory of Open Access Journals (Sweden)

    Mathias Basner

    2015-01-01

    Full Text Available The mandate of the International Commission on Biological Effects of Noise (ICBEN is to promote a high level of scientific research concerning all aspects of noise-induced effects on human beings and animals. In this review, ICBEN team chairs and co-chairs summarize relevant findings, publications, developments, and policies related to the biological effects of noise, with a focus on the period 2011-2014 and for the following topics: Noise-induced hearing loss; nonauditory effects of noise; effects of noise on performance and behavior; effects of noise on sleep; community response to noise; and interactions with other agents and contextual factors. Occupational settings and transport have been identified as the most prominent sources of noise that affect health. These reviews demonstrate that noise is a prevalent and often underestimated threat for both auditory and nonauditory health and that strategies for the prevention of noise and its associated negative health consequences are needed to promote public health.

  20. ICBEN review of research on the biological effects of noise 2011-2014

    Science.gov (United States)

    Basner, Mathias; Brink, Mark; Bristow, Abigail; de Kluizenaar, Yvonne; Finegold, Lawrence; Hong, Jiyoung; Janssen, Sabine A; Klaeboe, Ronny; Leroux, Tony; Liebl, Andreas; Matsui, Toshihito; Schwela, Dieter; Sliwinska-Kowalska, Mariola; Sörqvist, Patrik

    2015-01-01

    The mandate of the International Commission on Biological Effects of Noise (ICBEN) is to promote a high level of scientific research concerning all aspects of noise-induced effects on human beings and animals. In this review, ICBEN team chairs and co-chairs summarize relevant findings, publications, developments, and policies related to the biological effects of noise, with a focus on the period 2011-2014 and for the following topics: Noise-induced hearing loss; nonauditory effects of noise; effects of noise on performance and behavior; effects of noise on sleep; community response to noise; and interactions with other agents and contextual factors. Occupational settings and transport have been identified as the most prominent sources of noise that affect health. These reviews demonstrate that noise is a prevalent and often underestimated threat for both auditory and nonauditory health and that strategies for the prevention of noise and its associated negative health consequences are needed to promote public health. PMID:25774609